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Sample records for abattoir workers exposed

  1. Epidemiologic investigation of immune-mediated polyradiculoneuropathy among abattoir workers exposed to porcine brain.

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    Stacy M Holzbauer

    Full Text Available BACKGROUND: In October 2007, a cluster of patients experiencing a novel polyradiculoneuropathy was identified at a pork abattoir (Plant A. Patients worked in the primary carcass processing area (warm room; the majority processed severed heads (head-table. An investigation was initiated to determine risk factors for illness. METHODS AND RESULTS: Symptoms of the reported patients were unlike previously described occupational associated illnesses. A case-control study was conducted at Plant A. A case was defined as evidence of symptoms of peripheral neuropathy and compatible electrodiagnostic testing in a pork abattoir worker. Two control groups were used - randomly selected non-ill warm-room workers (n = 49, and all non-ill head-table workers (n = 56. Consenting cases and controls were interviewed and blood and throat swabs were collected. The 26 largest U.S. pork abattoirs were surveyed to identify additional cases. Fifteen cases were identified at Plant A; illness onsets occurred during May 2004-November 2007. Median age was 32 years (range, 21-55 years. Cases were more likely than warm-room controls to have ever worked at the head-table (adjusted odds ratio [AOR], 6.6; 95% confidence interval [CI], 1.6-26.7, removed brains or removed muscle from the backs of heads (AOR, 10.3; 95% CI, 1.5-68.5, and worked within 0-10 feet of the brain removal operation (AOR, 9.9; 95% CI, 1.2-80.0. Associations remained when comparing head-table cases and head-table controls. Workers removed brains by using compressed air that liquefied brain and generated aerosolized droplets, exposing themselves and nearby workers. Eight additional cases were identified in the only two other abattoirs using this technique. The three abattoirs that used this technique have stopped brain removal, and no new cases have been reported after 24 months of follow up. Cases compared to controls had higher median interferon-gamma (IFNgamma levels (21.7 pg/ml; vs 14.8 pg/ml, P<0

  2. The Impact of Physical and Ergonomic Hazards on Poultry Abattoir Processing Workers: A Review.

    Science.gov (United States)

    Harmse, Johannes L; Engelbrecht, Jacobus C; Bekker, Johan L

    2016-02-01

    The poultry abattoir industry continues to grow and contribute significantly to the gross domestic product in many countries. The industry expects working shifts of eight to eleven hours, during which workers are exposed to occupational hazards which include physical hazards ranging from noise, vibration, exposure to cold and ergonomic stress from manual, repetitive tasks that require force. A PubMed, Medline and Science Direct online database search, using specific keywords was conducted and the results confirmed that physical and ergonomic hazards impact on abattoir processing workers health, with harm not only to workers' health but also as an economic burden due to the loss of their livelihoods and the need for treatment and compensation in the industry. This review endeavours to highlight the contribution poultry processing plays in the development of physical agents and ergonomic stress related occupational diseases in poultry abattoir processing workers. The impact includes noise-induced hearing loss, increased blood pressure, menstrual and work related upper limb disorders. These are summarised as a quick reference guide for poultry abattoir owners, abattoir workers, poultry associations, occupational hygienists and medical practitioners to assist in the safer management of occupational health in poultry abattoirs.

  3. The Impact of Physical and Ergonomic Hazards on Poultry Abattoir Processing Workers: A Review.

    Science.gov (United States)

    Harmse, Johannes L; Engelbrecht, Jacobus C; Bekker, Johan L

    2016-02-01

    The poultry abattoir industry continues to grow and contribute significantly to the gross domestic product in many countries. The industry expects working shifts of eight to eleven hours, during which workers are exposed to occupational hazards which include physical hazards ranging from noise, vibration, exposure to cold and ergonomic stress from manual, repetitive tasks that require force. A PubMed, Medline and Science Direct online database search, using specific keywords was conducted and the results confirmed that physical and ergonomic hazards impact on abattoir processing workers health, with harm not only to workers' health but also as an economic burden due to the loss of their livelihoods and the need for treatment and compensation in the industry. This review endeavours to highlight the contribution poultry processing plays in the development of physical agents and ergonomic stress related occupational diseases in poultry abattoir processing workers. The impact includes noise-induced hearing loss, increased blood pressure, menstrual and work related upper limb disorders. These are summarised as a quick reference guide for poultry abattoir owners, abattoir workers, poultry associations, occupational hygienists and medical practitioners to assist in the safer management of occupational health in poultry abattoirs. PMID:26861374

  4. Food safety knowledge, attitude, and practice toward compliance with abattoir laws among the abattoir workers in Malaysia

    Directory of Open Access Journals (Sweden)

    Abdullahi A

    2016-04-01

    Full Text Available Auwalu Abdullahi,1–3 Azmi Hassan,1 Norizhar Kadarman,2 Ahmadu Saleh,4 Yusha’u Shu’aibu Baraya,5 Pei Lin Lua,61Institute for Community Development and Quality of Life  (i-CODE, Universiti Sultan Zainal Abidin (UniSZA, Kampus Gong Badak, Kuala Terengganu, Terengganu, Malaysia; 2Faculty of Medicine, Department of Community Medicine, Universiti Sultan Zainal Abidin (UniSZA, Kampus Kota, Jalan Sultan Mahmud, Kuala Terengganu, Terengganu, Malaysia; 3Department of Animal Health and Husbandry, Audu Bako College of Agriculture, Dambatta, Kano, Nigeria; 4School of Animal Science, Faculty of Bio-resources and Food Industry, Universiti Sultan Zainal Abidin (UniSZA, Terengganu, Malaysia; 5Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia (USM, Malaysia; 6Community Health Research Cluster, Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA, Kampus Gong Badak, Kuala Terengganu, Terengganu, Malaysia Purpose: Foodborne diseases are common in the developing countries due to the predominant poor food handling and sanitation practices, particularly as a result of inadequate food safety laws, weak regulatory structures, and inadequate funding as well as a lack of appropriate education for food-handlers. The most frequently involved foods in disease outbreaks are of animal origin. However, in spite of the adequate legislation and laws governing the abattoir operation in Malaysia, compliance with food safety requirements during meat processing and waste disposal is inadequate. Therefore, the present study was designed to assess the food safety knowledge, attitude, and practice toward compliance with abattoir laws among the workers in Terengganu, Malaysia. Materials and methods: A cross-sectional survey was conducted using simple random sampling technique in the six districts of Terengganu: two districts were used for the pilot study and the remaining four were used for the main study. One hundred sixty

  5. Case series of keratitis in poultry abattoir workers induced by exposure to the ultraviolet disinfection lamp

    OpenAIRE

    Kwon, Do-Hyeong; Moon, Jai-Dong; Park, Won-Ju; Kang, Won-Yang; Kim, Soo-Hyeon; Lim, Hyeong-Min; Ahn, Ji-Sung; Chae, Hong-Jae

    2016-01-01

    Background An outbreak of eye diseases occurred among workers at a poultry abattoir in South Korea from December 2012 to June 2013. An epidemiological investigation of the causative agent was conducted. The workers were given a special health examination and workplace environmental monitoring was performed. Workers with ocular symptoms subsequently underwent an ophthalmic examination. Case Presentaion From a total of 41 workers, 26 (63.4 %) were diagnosed with keratoepitheliopathy by ophthalm...

  6. Occupational hazards among the abattoir workers associated with noncompliance to the meat processing and waste disposal laws in Malaysia

    Science.gov (United States)

    Abdullahi, Auwalu; Hassan, Azmi; Kadarman, Norizhar; Junaidu, Yakubu Muhammad; Adeyemo, Olanike Kudrat; Lua, Pei Lin

    2016-01-01

    Purpose This study aims to investigate the occupational hazards among the abattoir workers associated with noncompliance to the meat processing and waste disposal laws in Terengganu State, Malaysia. Occupational hazards are the major source of morbidity and mortality among the animal workers due to exposure to many hazardous situations in their daily practices. Occupational infections mostly contracted by abattoir workers could be caused by iatrogenic or transmissible agents, including viruses, bacteria, fungi, and parasites and the toxins produced by these organisms. Materials and methods The methodology was based on a cross-sectional survey using cluster sampling technique in the four districts of Terengganu State, Malaysia. One hundred and twenty-one abattoir workers from five abattoirs were assessed using a validated structured questionnaire and an observation checklist. Results The mean and standard deviation of occupational hazards scores of the workers were 2.32 (2.721). Physical, chemical, biological, psychosocial, musculoskeletal, and ergonomics hazards were the major findings of this study. However, the highest prevalence of occupational hazards identified among the workers was injury by sharp equipment such as a knife (20.0%), noise exposure (17.0%), and due to offensive odor within the abattoir premises (12.0%). Conclusion The major occupational hazards encountered by the workers in the study area were physical, chemical, biological, psychosocial, musculoskeletal, and ergonomics hazards. To ensure proper control of occupational health hazards among the abattoir workers, standard design and good environmental hygiene must be taken into consideration all the time. Exposure control plan, which includes risk identification, risk characterization, assessment of workers at risk, risk control, workers’ education/training, and implementation of safe work procedures, should be implemented by the government and all the existing laws governing the abattoir

  7. Occupational hazards among the abattoir workers associated with noncompliance to the meat processing and waste disposal laws in Malaysia

    Directory of Open Access Journals (Sweden)

    Abdullahi A

    2016-07-01

    Full Text Available Auwalu Abdullahi,1–3 Azmi Hassan,1 Norizhar Kadarman,2 Yakubu Muhammad Junaidu,3 Olanike Kudrat Adeyemo,4,5 Pei Lin Lua6 1Institute for Community Development and Quality of Life (i-CODE, Universiti Sultan Zainal Abidin (UniSZA, Kampus Gong Badak, 2Faculty of Medicine, Department of Community Medicine, Universiti Sultan Zainal Abidin (UniSZA, Kampus Kota, Kuala Terengganu, Terengganu, Malaysia; 3Department of Animal Health and Husbandry, Audu Bako College of Agriculture Dambatta, Kano, Nigeria; 4Center for Human and Environmental Toxicology, Department of Physiological Sciences, University of Florida, Gainesville, FL, USA; 5Department of Veterinary Public Health and Preventive Medicine, University of Ibadan, Ibadan, Nigeria; 6Community Health Research Cluster, Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA, Kampus Gong Badak, Kuala Terengganu, Terengganu, Malaysia Purpose: This study aims to investigate the occupational hazards among the abattoir workers associated with noncompliance to the meat processing and waste disposal laws in Terengganu State, Malaysia. Occupational hazards are the major source of morbidity and mortality among the animal workers due to exposure to many hazardous situations in their daily practices. Occupational infections mostly contracted by abattoir workers could be caused by iatrogenic or transmissible agents, including viruses, bacteria, fungi, and parasites and the toxins produced by these organisms. Materials and methods: The methodology was based on a cross-sectional survey using cluster sampling technique in the four districts of Terengganu State, Malaysia. One hundred and twenty-one abattoir workers from five abattoirs were assessed using a validated structured questionnaire and an observation checklist. Results: The mean and standard deviation of occupational hazards scores of the workers were 2.32 (2.721. Physical, chemical, biological, psychosocial, musculoskeletal, and ergonomics hazards

  8. Evidence of Rickettsia and Orientia Infections Among Abattoir Workers in Djibouti.

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    Horton, Katherine C; Jiang, Ju; Maina, Alice; Dueger, Erica; Zayed, Alia; Ahmed, Ammar Abdo; Pimentel, Guillermo; Richards, Allen L

    2016-08-01

    Of 49 workers at a Djiboutian abattoir, eight (16%, 95% confidence interval [CI]: 9-29) were seropositive against spotted fever group rickettsiae (SFGR), two (4%, 95% CI: 1-14) against typhus group rickettsiae, and three (6%, 95% CI: 2-17) against orientiae. One worker (9%, 95% CI: 2-38) seroconverted against orientiae during the study period. This is the first evidence of orientiae exposure in the Horn of Africa. SFGR were also identified by polymerase chain reaction in 32 of 189 (11%, 95% CI: 8-15) tick pools from 26 of 72 (36%) cattle. Twenty-five (8%, 95% CI: 6-12) tick pools were positive for Rickettsia africae, the causative agent of African tick-bite fever. Health-care providers in Djibouti should be aware of the possibility of rickettsiae infections among patients, although further research is needed to determine the impact of these infections in the country. PMID:27273647

  9. Antimicrobial drug resistance of Escherichia coli isolated from poultry abattoir workers at risk and broilers on antimicrobials

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    J.W. Oguttu

    2008-05-01

    Full Text Available Antimicrobial usage in food animals increases the prevalence of antimicrobial drug resistance among their enteric bacteria. It has been suggested that this resistance can in turn be transferred to people working with such animals, e.g. abattoir workers. Antimicrobial drug resistance was investigated for Escherichia coli from broilers raised on feed supplemented with antimicrobials, and the people who carry out evisceration, washing and packing of intestines in a high-throughput poultry abattoir in Gauteng, South Africa. Broiler carcasses were sampled from 6 farms, on each of which broilers are produced in a separate 'grow-out cycle'. Per farm, 100 caeca were randomly collected 5 minutes after slaughter and the contents of each were selectively cultured for E. coli. The minimum inhibitory concentration (MIC of each isolate was determined for the following antimicrobials : doxycycline, trimethoprim, sulphamethoxazole, ampicillin, enrofloxacin, fosfomycin, ceftriaxone and nalidixic acid. The same was determined for the faeces of 29 abattoir workers and 28 persons used as controls. The majority of isolates from broilers were resistant, especially to antimicrobials that were used on the farms in the study. Overall median MICs and the number of resistant isolates from abattoir workers (packers plus eviscerators tended to be higher than for the control group. However, no statistically significant differences were observed when the median MICs of antimicrobials used regularly in poultry and percentage resistance were compared, nor could an association between resistance among the enteric E. coli from packers and those from broilers be demonstrated.

  10. Eryptosis in lead-exposed workers

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar-Dorado, Itzel-Citlalli [Biochemistry Department, Centro de Investigación y Estudios Avanzados IPN, México, DF (Mexico); Hernández, Gerardo [Section of Methodology of Science, Centro de Investigación y Estudios Avanzados IPN, México, DF (Mexico); Quintanar-Escorza, Martha-Angelica [Faculty of Medicine, UJED, Durango, DGO (Mexico); Maldonado-Vega, María [CIATEC, León, GTO (Mexico); Rosas-Flores, Margarita [Biochemistry Department, Centro de Investigación y Estudios Avanzados IPN, México, DF (Mexico); Calderón-Salinas, José-Víctor, E-mail: jcalder@cinvestav.mx [Biochemistry Department, Centro de Investigación y Estudios Avanzados IPN, México, DF (Mexico)

    2014-12-01

    Eryptosis is a physiological phenomenon in which old and damaged erythrocytes are removed from circulation. Erythrocytes incubated with lead have exhibited major eryptosis. In the present work we found evidence of high levels of eryptosis in lead exposed workers possibly via oxidation. Blood samples were taken from 40 male workers exposed to lead (mean blood lead concentration 64.8 μg/dl) and non-exposed workers (4.2 μg/dl). The exposure to lead produced an intoxication characterized by 88.3% less δ-aminolevulinic acid dehydratase (δALAD) activity in lead exposed workers with respect to non-lead exposed workers. An increment of oxidation in lead exposed workers was characterized by 2.4 times higher thiobarbituric acid-reactive substance (TBARS) concentration and 32.8% lower reduced/oxidized glutathione (GSH/GSSG) ratio. Oxidative stress in erythrocytes of lead exposed workers is expressed in 192% higher free calcium concentration [Ca{sup 2+}]{sub i} and 1.6 times higher μ-calpain activity with respect to non-lead exposed workers. The adenosine triphosphate (ATP) concentration was not significantly different between the two worker groups. No externalization of phosphatidylserine (PS) was found in non-lead exposed workers (< 0.1%), but lead exposed workers showed 2.82% externalization. Lead intoxication induces eryptosis possibly through a molecular pathway that includes oxidation, depletion of reduced glutathione (GSH), increment of [Ca{sup 2+}], μ-calpain activation and externalization of PS in erythrocytes. Identifying molecular signals that induce eryptosis in lead intoxication is necessary to understand its physiopathology and chronic complications. - Graphical abstract: Fig. 1. (A) Blood lead concentration (PbB) and (B) phosphatidylserine externalization on erythrocyte membranes of non-lead exposed (□) and lead exposed workers (■). Values are mean ± SD. *Significantly different (P < 0.001). - Highlights: • Erythrocytes of lead exposed workers

  11. Eryptosis in lead-exposed workers

    International Nuclear Information System (INIS)

    Eryptosis is a physiological phenomenon in which old and damaged erythrocytes are removed from circulation. Erythrocytes incubated with lead have exhibited major eryptosis. In the present work we found evidence of high levels of eryptosis in lead exposed workers possibly via oxidation. Blood samples were taken from 40 male workers exposed to lead (mean blood lead concentration 64.8 μg/dl) and non-exposed workers (4.2 μg/dl). The exposure to lead produced an intoxication characterized by 88.3% less δ-aminolevulinic acid dehydratase (δALAD) activity in lead exposed workers with respect to non-lead exposed workers. An increment of oxidation in lead exposed workers was characterized by 2.4 times higher thiobarbituric acid-reactive substance (TBARS) concentration and 32.8% lower reduced/oxidized glutathione (GSH/GSSG) ratio. Oxidative stress in erythrocytes of lead exposed workers is expressed in 192% higher free calcium concentration [Ca2+]i and 1.6 times higher μ-calpain activity with respect to non-lead exposed workers. The adenosine triphosphate (ATP) concentration was not significantly different between the two worker groups. No externalization of phosphatidylserine (PS) was found in non-lead exposed workers (< 0.1%), but lead exposed workers showed 2.82% externalization. Lead intoxication induces eryptosis possibly through a molecular pathway that includes oxidation, depletion of reduced glutathione (GSH), increment of [Ca2+], μ-calpain activation and externalization of PS in erythrocytes. Identifying molecular signals that induce eryptosis in lead intoxication is necessary to understand its physiopathology and chronic complications. - Graphical abstract: Fig. 1. (A) Blood lead concentration (PbB) and (B) phosphatidylserine externalization on erythrocyte membranes of non-lead exposed (□) and lead exposed workers (■). Values are mean ± SD. *Significantly different (P < 0.001). - Highlights: • Erythrocytes of lead exposed workers showed higher PS

  12. Anesthetic gases and occupationally exposed workers.

    Science.gov (United States)

    Casale, Teodorico; Caciari, Tiziana; Rosati, Maria Valeria; Gioffrè, Pier Agostino; Schifano, Maria Pia; Capozzella, Assunta; Pimpinella, Benedetta; Tomei, Gianfranco; Tomei, Francesco

    2014-01-01

    The aim of this study is to estimate whether the occupational exposure to low dose anesthetic gases could cause alterations of blood parameters in health care workers. 119 exposed subjects and 184 not exposed controls were included in the study. Each worker underwent the complete blood count test (CBC), proteinaemia, leukocyte count, serum lipids, liver and kidney blood markers. The liver blood markers show statistically significant differences in health care workers compared with controls (pGGT, total bilirubin, lymphocytes and neutrophils was statistically significant in health care workers compared with controls (p<0.05). The results suggest that occupational exposure to low dose anesthetic gases could influence some haematochemical hepatic and hematopoietic parameters in exposed health care workers. PMID:24374387

  13. Work ability in vibration-exposed workers

    OpenAIRE

    Gerhardsson, L; Hagberg, M

    2014-01-01

    Background Hand–arm vibration exposure may cause hand–arm vibration syndrome (HAVS) including sensorineural disturbances. Aims To investigate which factors had the strongest impact on work ability in vibration-exposed workers. Methods A cross-sectional study in which vibration-exposed workers referred to a department of occupational and environmental medicine were compared with a randomized sample of unexposed subjects from the general population of the city of Gothenburg. All participants un...

  14. Occupational health care of radiation exposed workers

    International Nuclear Information System (INIS)

    The medical problems encountered by the earlier pioneer workers in radiation at the turn of the century are well known. In the 1928, the ICRP (International Committee for Radiological Protection) was instituted and the ALARA principle of radiation protection was evolved. Occupational health care is about maintaining the health and safety of workers in their workplaces. This involves using medical, nursing and engineering practices to achieve its objectives. In certain occupations, including those where workers are exposed to ionising radiation, some of these principles are enshrined in the legislation and would require statutory compliance. Occupational health care of radiation workers seek to prevent ill health arising from exposure to radiation by consolidating the benefits of exposures control and dosimetry. This is via health surveillance for spillages, contamination and exposures to unsealed sources of radiation. It is unlikely that can plan and hope to cater for a Chernobyl type of disaster. However, for the multitude of workers in industry exposed to radiation, control models are available. These are from the more in industrialize countries with a nuclear based energy industry, and where radioactive gadgetry are used in places ranging from factories and farms to construction sites. These models involve statutory requirements on the standard of work practices, assessment of fitness to work and the monitoring of both the worker and the workplace. A similar framework of activity is present in Malaysia. This will be further enhanced with the development of her general health and safety at work legislation. (author)

  15. Fibrosis biomarkers in workers exposed to MWCNTs.

    Science.gov (United States)

    Fatkhutdinova, Liliya M; Khaliullin, Timur O; Vasil'yeva, Olga L; Zalyalov, Ramil R; Mustafin, Ilshat G; Kisin, Elena R; Birch, M Eileen; Yanamala, Naveena; Shvedova, Anna A

    2016-05-15

    Multi-walled carbon nanotubes (MWCNT) with their unique physico-chemical properties offer numerous technological advantages and are projected to drive the next generation of manufacturing growth. As MWCNT have already found utility in different industries including construction, engineering, energy production, space exploration and biomedicine, large quantities of MWCNT may reach the environment and inadvertently lead to human exposure. This necessitates the urgent assessment of their potential health effects in humans. The current study was carried out at NanotechCenter Ltd. Enterprise (Tambov, Russia) where large-scale manufacturing of MWCNT along with relatively high occupational exposure levels was reported. The goal of this small cross-sectional study was to evaluate potential biomarkers during occupational exposure to MWCNT. All air samples were collected at the workplaces from both specific areas and personal breathing zones using filter-based devices to quantitate elemental carbon and perform particle analysis by TEM. Biological fluids of nasal lavage, induced sputum and blood serum were obtained from MWCNT-exposed and non-exposed workers for assessment of inflammatory and fibrotic markers. It was found that exposure to MWCNTs caused significant increase in IL-1β, IL6, TNF-α, inflammatory cytokines and KL-6, a serological biomarker for interstitial lung disease in collected sputum samples. Moreover, the level of TGF-β1 was increased in serum obtained from young exposed workers. Overall, the results from this study revealed accumulation of inflammatory and fibrotic biomarkers in biofluids of workers manufacturing MWCNTs. Therefore, the biomarkers analyzed should be considered for the assessment of health effects of occupational exposure to MWCNT in cross-sectional epidemiological studies. PMID:26902652

  16. Self-reported hearing performance in workers exposed to solvents

    OpenAIRE

    Adrian Fuente; Bradley McPhersonY; Ximena Hormazabal

    2013-01-01

    OBJECTIVE: To compare hearing performance relating to the peripheral and central auditory system between solvent-exposed and non-exposed workers. METHODS: Forty-eight workers exposed to a mixture of solvents and 48 non-exposed control subjects of matched age, gender and educational level were selected to participate in the study. The evaluation procedures included: pure-tone audiometry (500 - 8,000 Hz), to investigate the peripheral auditory system; the Random Gap Detection test, to assess th...

  17. Neurotoxicity of Acrylamide in Exposed Workers

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    Mariano Malaguarnera

    2013-08-01

    Full Text Available Acrylamide (ACR is a water-soluble chemical used in different industrial and laboratory processes. ACR monomer is neurotoxic in humans and laboratory animals. Subchronic exposure to this chemical causes neuropathies, hands and feet numbness, gait abnormalities, muscle weakness, ataxia, skin and in some cases, cerebellar alterations. ACR neurotoxicity involves mostly the peripheral but also the central nervous system, because of damage to the nerve terminal through membrane fusion mechanisms and tubulovescicular alterations. Nevertheless, the exact action mechanism is not completely elucidated. In this paper we have reviewed the current literature on its neurotoxicity connected to work-related ACR exposure. We have analyzed not only the different pathogenetic hypotheses focusing on possible neuropathological targets, but also the critical behavior of ACR poisoning. In addition we have evaluated the ACR-exposed workers case studies. Despite all the amount of work which have being carried out on this topic more studies are necessary to fully understand the pathogenetic mechanisms, in order to propose suitable therapies.

  18. Monitoring of workers exposed to neutrons. Information note

    International Nuclear Information System (INIS)

    This document briefly indicates who are the workers exposed to neutrons in nuclear facilities, what is the peculiarity of neutron radiation, what is the evolution of scientific knowledge about neutrons, which are the technical evolutions in neutron dosimetry, which are the regulatory evolutions about neutron dosimetry, and how the monitoring of workers exposed to neutrons has been performed in 2011

  19. Health effects among refrigeration repair workers exposed to fluorocarbons.

    OpenAIRE

    Campbell, D D; Lockey, J E; Petajan, J; Gunter, B J; Rom, W N

    1986-01-01

    Refrigeration repair workers may be intermittently exposed to fluorocarbons and their thermal decomposition products. A case of peripheral neuropathy (distal axonopathy) in a commercial refrigeration repairman prompted an epidemiological investigation of the health of refrigeration repair workers. No additional cases of peripheral neuropathy were identified among the 27 refrigeration repair workers studied. A reference group of 14 non-refrigeration repair workers was also studied. No differen...

  20. Medical surveillance of occupationally exposed workers

    Energy Technology Data Exchange (ETDEWEB)

    2007-05-15

    The guide covers medical surveillance of workers engaged in radiation work and their fitness for this work, protection of the foetus and infant during the worker's pregnancy or breastfeeding, and medical surveillance measures to be taken when the dose limit has been exceeded. The guide also covers recognition of practitioners responsible for medical surveillance of category A workers, medical certificates to be issued to workers, and preservation and transfer of medical records. The medical surveillance requirements specified in this Guide cover the use of radiation and nuclear energy. The guide also applies to exposure to natural radiation in accordance with section 28 of the Finnish Radiation Decree

  1. Medical surveillance of occupationally exposed workers

    International Nuclear Information System (INIS)

    The guide covers medical surveillance of workers engaged in radiation work and their fitness for this work, protection of the foetus and infant during the worker's pregnancy or breastfeeding, and medical surveillance measures to be taken when the dose limit has been exceeded. The guide also covers recognition of practitioners responsible for medical surveillance of category A workers, medical certificates to be issued to workers, and preservation and transfer of medical records. The medical surveillance requirements specified in this Guide cover the use of radiation and nuclear energy. The guide also applies to exposure to natural radiation in accordance with section 28 of the Finnish Radiation Decree

  2. Nasal mucosa in workers exposed to formaldehyde: a pilot study.

    OpenAIRE

    Boysen, M; Zadig, E; Digernes, V; Abeler, V; Reith, A.

    1990-01-01

    This study evaluates the histological changes, especially the presence of possible precancerous lesions, in the nasal mucosa of workers exposed to formaldehyde. Nasal biopsies of 37 workers occupationally exposed to formaldehyde for more than five years and 37 age matched referents showed a higher degree of metaplastic alterations in the former group. In addition, three cases of epithelial dysplasia were observed among the exposed. These results indicate that formaldehyde may be potentially c...

  3. Investigating genetic damage in workers occupationally exposed to methotrexate

    Institute of Scientific and Technical Information of China (English)

    何继亮

    2005-01-01

    @@ In this article, the genetic damage at 3 genetic endpoints in the workers occupationally exposed to antineoplastc drug was studied with micronucleus test, comet assay, hprt gene mutation assay and TCR gene mutation assay.

  4. Health of workers exposed to electric fields.

    Science.gov (United States)

    Broadbent, D E; Broadbent, M H; Male, J C; Jones, M R

    1985-02-01

    The results of health questionnaire interviews with 390 electrical power transmission and distribution workers, together with long term estimates of their exposure to 50 Hz electric fields, and short term measurements of the actual exposure for 287 of them are reported. Twenty eight workers received measurable exposures, averaging about 30 kVm-1h over the two week measurement period. Estimated exposure rates were considerably greater, but showed fair correlation with the measurements. Although the general level of health was higher than we have found in manual workers in other industries, there were significant differences in the health measures between different categories of job, different parts of the country, and in association with factors such as overtime, working alone, or frequently changing shift. After allowing for the effects of job and location, however, we found no significant correlations of health with either measured or estimated exposure to electric fields. PMID:3970875

  5. Cataract incidence in the cohort of occupationally exposed workers

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    E. V. Bragin

    2016-01-01

    Full Text Available Objective: To assess cataract incidence in the cohort of workers occupationally exposed to prolonged radiation. Material and Methods: Cataract incidence was studied in the cohort of workers of the first Russian nuclear enterprise — the Mayak, who were firstly employed at one of the main facilities (reactors, radiochemical and plutonium production plants in 1948‑1958 and followed up to the end of 2008 (12210 persons. Total of 3100 cataract cases were registered in the study cohort. All cataract cases were reviewed and verified by experts; the study included only confirmed senile cataracts. All workers of the study cohort were exposed to external gamma-rays; mean cumulative dose from external gamma-rays was 0.91±0.01 Gy in males and 0.65±0.01 Gy in females. Statistical analysis provided non-standardized and standardized incidence rates per 100 000 workers. Standardization by sex and age was performed by indirect method using internal reference.Results: 2523 cases of senile cataract were included in the study. Mean age of cataract diagnosis was 62.88±0.26 years in males and 64.88±0.28 years in females. Standardized incidence rates of cataract in females were significantly higher as compared to males and increased with workers age. Comparison between the subcohorts of workers with / without diagnosed cataracts demonstrated that among workers with cataracts the proportions of the following groups of workers were significantly higher: workers employed before 1954; workers employed at reactors; smoking workers; workers with the smoking index exceeding 20 pack*years; workers who consumed alcohol; workers with excessive body weight; workers with glaucoma and arterial hypertension. Moreover the mean cumulative dose from external gamma-rays and / or neutron exposure was significantly higher in the subcohort of workers diagnosed with cataracts than that in the subcohort of workers free of the disease. The highest cataract incidence

  6. Risk practices and awareness of leptospirosis in an abattoir in northwestern Nigeria

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    Emmanuel Ochefije Ngbede

    2012-08-01

    Full Text Available The study was designed to assess the presence of risk practices and level of awareness of leptospirosis among abattoir workers. The study was conducted in an abattoir located in Northwestern Nigeria. Pretested questionnaires were administered via interview to 73 of the abattoir workers willing to participate in the study. There was there was a low level (5.48% of awareness of leptospirosis among the abattoir workers. Also risk practices for infection by Leptospira were present among the abattoir workers. This study has shown that the abattoir workers are at risk of infection by Leptospira in the course of their work due to the low level of awareness of the disease, the presence of risk practices and inadequate use of protective clothing.

  7. Impairment of colour vision in workers exposed to organic solvents

    OpenAIRE

    Semple, S.; Dick, F.; Osborne, A.; Cherrie, J; Soutar, A; Seaton, A.; Haites, N.

    2000-01-01

    OBJECTIVES—To investigate loss of colour vision related to exposure to solvents and the role of three enzyme polymorphisms in modifying the risk in exposed workers.
METHODS—A sample was studied of 68 male dockyard workers and 42 male community controls with and without neuropsychological symptoms from a previous cross sectional study. Indices of cumulative and intensity based exposure to solvents were calculated for all subjects. Alcohol, drug, and smoking histories were obtained. Colour visi...

  8. Tuberculosis among workers exposed to free silica dust.

    Science.gov (United States)

    Tiwari, Rajnarayan R; Sharma, Yashwant K; Saiyed, Habibullah N

    2007-05-01

    Tuberculosis (TB) is a global emergency. Poverty, increasing migration, homelessness and the compulsions to live and work in high-risk environments are making people increasingly susceptible to the disease. Those working in mines, construction work, stone-crushing and in other similar occupations where there is a greater level of exposure to silica dust are specially vulnerable. Though the association between TB and silicosis has been firmly established by the results of epidemiologic studies no attempts have been made to study the epidemiological features of radiologically active TB among free silica exposed workers. Thus the cross sectional study was carried out among slate pencil workers and quartz stone crushers to assess the prevalence of TB and some associated epidemiological factors. It included 253 quartz workers and 102 slate pencil workers. Clinical history and chest radiographs were used for labeling the subjects as tuberculotic. The pulmonary functions of the subjects were measured using Spirovit SP- 10. Statistical analysis was carried out using statistical software package Epi Info 3.3.2. Among stone crushers the prevalence of TB was found to be 10.7% while among slate pencil workers it was as high as 22.5%. Among the quartz stone-crushers the workers aged ≥35 years, those exposed for ≥3 years and those who were smokers had higher risk TB while among the slate pencil workers, only those exposed for ≥10 years had higher risk. Though the FVC and FEV(1) values of the workers having TB were lower than those having normal radiographs, the differences were found to statistically non-significant.

  9. Tuberculosis among workers exposed to free silica dust

    Directory of Open Access Journals (Sweden)

    Tiwari Rajnarayan

    2007-01-01

    Full Text Available Tuberculosis (TB is a global emergency. Poverty, increasing migration, homelessness and the compulsions to live and work in high-risk environments are making people increasingly susceptible to the disease. Those working in mines, construction work, stone-crushing and in other similar occupations where there is a greater level of exposure to silica dust are specially vulnerable. Though the association between TB and silicosis has been firmly established by the results of epidemiologic studies no attempts have been made to study the epidemiological features of radiologically active TB among free silica exposed workers. Thus the cross sectional study was carried out among slate pencil workers and quartz stone crushers to assess the prevalence of TB and some associated epidemiological factors. It included 253 quartz workers and 102 slate pencil workers. Clinical history and chest radiographs were used for labeling the subjects as tuberculotic. The pulmonary functions of the subjects were measured using Spirovit SP- 10. Statistical analysis was carried out using statistical software package Epi Info 3.3.2. Among stone crushers the prevalence of TB was found to be 10.7% while among slate pencil workers it was as high as 22.5%. Among the quartz stone-crushers the workers aged ≥35 years, those exposed for ≥3 years and those who were smokers had higher risk TB while among the slate pencil workers, only those exposed for ≥10 years had higher risk. Though the FVC and FEV 1 values of the workers having TB were lower than those having normal radiographs, the differences were found to statistically non-significant.

  10. Chromosome aberrations in pesticide-exposed greenhouse workers

    DEFF Research Database (Denmark)

    Lander, B F; Knudsen, Lisbeth E.; Gamborg, M O;

    2000-01-01

    OBJECTIVES: The aim of this study was to investigate the possibility of subtoxic exposure to pesticides causing chromosome aberrations in greenhouse workers. METHODS: In a cross-sectional and prospective study design chromosome aberration frequencies in cultured lymphocytes were examined for 116...... greenhouse workers exposed to a complex mixture of almost 50 insecticides, fungicides, and growth regulators and also for 29 nonsmoking, nonpesticide-exposed referents. RESULTS: The preseason frequencies of chromosome aberrations were slightly but not statistically significantly elevated for the greenhouse...... workers when they were compared with the referents. After a summer season of pesticide spraying in the greenhouses, the total frequencies of cells with chromosome aberrations were significantly higher than in the preseason samples (P=0.02) and also higher than for the referents (P=0.05). This finding...

  11. Screening and surveillance of workers exposed to mineral dusts

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, G.R.

    1997-12-31

    This publication resulted from a World Health Organisation initiated project to investigate the harmonisation of definitions, approaches and methodologies for the screening and surveillance of workers exposed to mineral dust. The first part of the book provides definitions of screening and surveillance and describes the main elements of such programmes. The second part discusses the practical aspect of the screening and surveillance of working populations exposed to crystalline silica, coal mine dust and asbestos. Although no single set of guidelines is applicable to the development and implementation of a programme for the screening and surveillance of workers exposed to mineral dust, the recommendations, together with certain caveats, should provide a useful starting point. Annexes provide examples of existing programmes in various countries and environments and discuss the use and interpretation of questionnaires, lung spirometry and chest radiography. Overall the book should be of interest to occupational health professionals.

  12. Self-reported hearing performance in workers exposed to solvents

    Directory of Open Access Journals (Sweden)

    Adrian Fuente

    2013-02-01

    Full Text Available OBJECTIVE: To compare hearing performance relating to the peripheral and central auditory system between solvent-exposed and non-exposed workers. METHODS: Forty-eight workers exposed to a mixture of solvents and 48 non-exposed control subjects of matched age, gender and educational level were selected to participate in the study. The evaluation procedures included: pure-tone audiometry (500 - 8,000 Hz, to investigate the peripheral auditory system; the Random Gap Detection test, to assess the central auditory system; and the Amsterdam Inventory for Auditory Disability and Handicap, to investigate subjects' self-reported hearing performance in daily-life activities. A Student t test and analyses of covariance (ANCOVA were computed to determine possible significant differences between solvent-exposed and non-exposed subjects for the hearing level, Random Gap Detection test and Amsterdam Inventory for Auditory Disability and Handicap. Pearson correlations among the three measures were also calculated. RESULTS: Solvent-exposed subjects exhibited significantly poorer hearing thresholds for the right ear than non-exposed subjects. Also, solvent-exposed subjects exhibited poorer results for the Random Gap Detection test and self-reported poorer listening performance than non-exposed subjects. Results of the Amsterdam Inventory for Auditory Disability and Handicap were significantly correlated with the binaural average of subject pure-tone thresholds and Random Gap Detection test performance. CONCLUSIONS: Solvent exposure is associated with poorer hearing performance in daily life activities that relate to the function of the peripheral and central auditory system.

  13. Cardiovascular changes in workers exposed to fine particulate dust

    Directory of Open Access Journals (Sweden)

    Alicja Bortkiewicz

    2014-02-01

    Full Text Available Objectives: Epidemiological studies provide evidence that airborne particulate matter may contribute to the increased incidence and mortality rates due to pulmonary and cardiovascular diseases. Only some of them address the problem of occupational exposure to particulate air pollution. The aim of our study was to assess cardiovascular reaction and autonomic regulation in workers exposed to fine particles. Materials and Methods: All workers had medical examination, resting ECG with heart rate variability analysis (HRV, 24-h ECG, and ambulatory blood pressure monitoring (ABPM performed. The subjects were 20 male workers (mean age: 32.14.0 year of a ceramic ware factory exposed to the dust and 20 workers who were not exposed (mean age: 39.4±7.8 year. The period of employment under exposure amounted to 5.6±2.1 year. Dust exposure was measured using individual dosimeters. Results: The geometric mean total dust concentration was 44±1.5 mg/m3 and the FPD (fine particulate dust concentration amounted to 11.5±1.6 mg/m3. No abnormalities were noted in the resting ECG in both groups, in 24-h ECG 2 subjects, both from exposed and control groups, had ventricular heart rhythm and repolarization disturbances. Blood pressure in ABPM, both systolic as well as diastolic, was normal and did not differ between the groups. Resting heart rate in the exposed group was significantly lower (p = 0.038 than in the control group. In the exposed group STD R-R from short-term records was significantly higher (p = 0.01. Fast Fourier Transform (FFT analysis showed that the low frequency power spectrum (LF did not differ in the exposed and the control group, while high frequency (HF was significantly higher in the exposed group. LF/HF ratio was significantly lower in the exposed in comparison with the control group. Conclusions: Although we did not reveal significant abnormalities in ECG as well as in ABPM in the exposed group, it seems that neurovegetative disturbances

  14. Lung scintigraphy evaluation in workers exposed to abrasive dusts

    International Nuclear Information System (INIS)

    The production process of abrasives use aluminium, or silicon carbide a synthetic material with a hardness only slightly less than that of a diamond. It is popularly known as carborundum since it was first manufactured as an abrasive in 1891, produced by the fusion of high grade silica and petroleum coke with sawdust. For many years silicon carbide was thought not to give rise to pulmonary lesions. Recently several researchers suggested the existence of a carborundum pneumoconiosis. The aim of this study was to evaluate the role of the pulmonary clearance of 99m Technetium chelated to diethylene-triamine penta-acetate (99m Tc DTPA), and 67 Gallium lung scanning in workers exposed to abrasive dusts. Thirty seven subjects, 13 smokers and 24 nonsmokers and ex smokers were studied. In 32 (86,48%) 67 Gallium lung scanning was positive including 13 (40,62%) retired workers. We conclude that non smoking workers of abrasives plants have a pulmonary alveolar epithelial permeability disturbance similar as observed in smoking workers and smoking controls. Most workers, ex-workers of these industries and in patients with carborundum pneumoconiosis there is an evidence of pulmonary inflammation measured with abnormal 67 Gallium lung scan. (author)

  15. Studies on chromosome aberrations in workers occupationally exposed to radiation

    International Nuclear Information System (INIS)

    Cytogenetic assays for unstable chromosomes were performed on 54 medical radiation workers who are occupationally exposed to radiation and 42 controls. A total of 15,577 metaphase cells were scored. The frequencies of dicentrics and acentric chromosomes on controls were 0.52*10-3 and 0.82*10-2, respectively. On radiation workers those were 2.28*10-3 and 1.34*10-2, respectively. Though the frequencies of all types of chromosome aberrations in the workers were higher than those in the controls, the only significant difference was found in the case of dicentrics (P 0.05) except exposure dose of recent one year (P < 0.05). These results could indicate that low level exposure to ionizing radiation can induce unstable chromosome aberrations in blood lymphocytes

  16. Chest X ray examination of workers exposed to pneumoconiosis risk

    International Nuclear Information System (INIS)

    Chest X-ray examination of workers exposed to pneumoconiosis risk: critical analysis of legal and radiation protection aspects. Chest X-ray examination is one of the most common radiological examinations practised in Italy. According to Presidential Decree 1124/65, workers exposed to risk of asbestosis and silicosis must undergo a chest radiography once a year, on occasion of the periodic medical examination. Basic requirements aimed at the radiation protection of the patient must therefore be complied with, and optimization of the chest radiography execution procedures is required. This paper illustrates the results obtained with the implementation of the NEXT programme in Italy for this kind of X-ray examination. The main objective of the NEXT programme is the optimization of radiological techniques. On the basis of the most recent publications in the field of radiation protection, a critical analysis is made of the laws in force in Italy

  17. Prevalence of latent and active tuberculosis among dairy farm workers exposed to cattle infected by Mycobacterium bovis.

    Directory of Open Access Journals (Sweden)

    Pedro Torres-Gonzalez

    Full Text Available BACKGROUND: Human tuberculosis caused by M. bovis is a zoonosis presently considered sporadic in developed countries, but remains a poorly studied problem in low and middle resource countries. The disease in humans is mainly attributed to unpasteurized dairy products consumption. However, transmission due to exposure of humans to infected animals has been also recognized. The prevalence of tuberculosis infection and associated risk factors have been insufficiently characterized among dairy farm workers (DFW exposed in settings with poor control of bovine tuberculosis. METHODOLOGY/PRINCIPAL FINDINGS: Tuberculin skin test (TST and Interferon-gamma release assay (IGRA were administered to 311 dairy farm and abattoir workers and their household contacts linked to a dairy production and livestock facility in Mexico. Sputa of individuals with respiratory symptoms and samples from routine cattle necropsies were cultured for M. bovis and resulting spoligotypes were compared. The overall prevalence of latent tuberculosis infection (LTBI was 76.2% (95% CI, 71.4-80.9% by TST and 58.5% (95% CI, 53.0-64.0% by IGRA. Occupational exposure was associated to TST (OR 2.72; 95% CI, 1.31-5.64 and IGRA (OR 2.38; 95% CI, 1.31-4.30 adjusting for relevant variables. Two subjects were diagnosed with pulmonary tuberculosis, both caused by M. bovis. In one case, the spoligotype was identical to a strain isolated from bovines. CONCLUSIONS: We documented a high prevalence of latent and pulmonary TB among workers exposed to cattle infected with M. bovis, and increased risk among those occupationally exposed in non-ventilated spaces. Interspecies transmission is frequent and represents an occupational hazard in this setting.

  18. Serological prevalence of leptospirosis in cattle slaughtered in the Zango abattoir in Zaria, Kaduna State, Nigeria

    Directory of Open Access Journals (Sweden)

    Emmanuel O. Ngbede

    2012-06-01

    Full Text Available Leptospirosis is an occupational zoonosis caused by pathogenic leptospires. In this study, the presence and prevalence of antibodies specific to Leptospira spp. serovar Hardjo in 142 cattle slaughtered between June and July 2011 was investigated using the enzyme-linked immunosorbent assay (ELISA. Five (3.50% of the 142 cattle sampled were seropositive for antibodies to Leptospira spp. serovar Hardjo. Despite the fact that there was no significant difference (p>0.05 in seropositivity between sexes and between breeds sampled, there was a significant difference (p<0.05 in sero-positivity between the different age groups examined. Leptospirosis is present in cattle slaughtered in the Zango abattoir; butchers and abattoir workers are exposed to infected animals and are at risk of being infected by Leptospira spp. serovar Hardjo.

  19. Medical monitoring of asbestos-exposed workers: experience from Poland.

    Science.gov (United States)

    Świątkowska, Beata; Szeszenia-Dąbrowska, Neonila; Wilczyńska, Urszula

    2016-08-01

    In Poland, the use of asbestos was banned in 1997 and asbestos plants have been closed since then. Despite their closure, cases of asbestos-related occupational diseases among former asbestos workers are still being recorded in the Central Register of Occupational Diseases. Between 2001 and 2014, there were 2726 asbestos-related illnesses, classified and reported as diseases associated with occupational exposure to asbestos. In 2000, Poland introduced a programme called Amiantus, targeted at former asbestos-processing plant workers. The programme provided periodic medical examinations to workers and free access to medications for treatment of asbestos-related illnesses. Introduction of the programme provided additional data to generate a reliable estimation of the number of asbestos-related occupational diseases, including cancer. The average latency period for asbestosis, lung cancer and mesothelioma is about 40 years so there may still be some health impact to former workers necessitating follow-up. We present the Polish experience of implementing a medical examination programme for asbestos-exposed workers and provide a list of activities to consider when planning for such a programme. PMID:27516637

  20. Airway inflammation among compost workers exposed to actinomycetes spores

    Directory of Open Access Journals (Sweden)

    Kari Kulvik Heldal

    2015-05-01

    Full Text Available Objectives. To study the associations between exposure to bioaerosols and work-related symptoms, lung function and biomarkers of airway inflammation in compost workers. Materials and method. Personal full-shift exposure measurements were performed on 47 workers employed at five windrow plants (n=20 and five reactor plants (n=27. Samples were analyzed for endotoxins, bacteria, fungal and actinomycetes spores. Health examinations were performed on workers and 37 controls before and after work on the day exposure was measured. The examinations included symptoms recorded by questionnaire, lung function by spirometry and nasal dimensions by acoustic rhinometry (AR. The pneumoproteins CC16, SP-D and SP-A were measured in a blood sample drawn at the end of the day. Results. The levels of endotoxins (median 3 EU/m[sup]3[/sup] , range 0–730 EU/m[sup]3[/sup] and actinomycetes spores (median 0.2 × 10[sup]6[/sup] spores/m[sup]3[/sup] , range 0–590 × 10[sup]6[/sup] spores/m[sup]3[/sup] were significantly higher in reactor plants compared to windrow plants. However, windrow composting workers reported more symptoms than reactor composting workers, probably due to use of respiratory protection. Exposure-response relationships between actinomycetes spores exposure and respiratory effects, found as cough and nose irritation during a shift, was significantly increased (OR 4.3, 95% CI 1.1–16, OR 6.1, 95% CI 1.5–25, respectively, p<0.05 among workers exposed to 0.02–0.3 × 10[sup]6[/sup] actinomycetes spores/m 3 , and FEV1/FVC% decreased cross shift (b=–3.2, SE=1.5%, p<0.01. Effects were weaker in the highest exposed group, but these workers used respiratory protection, frequently limiting their actual exposure. No relationships were found between exposure and pneumoprotein concentrations. Conclusions. The major agent in the aerosol generated at compost plants was actinomycetes spores which was associated with work related cough symptoms and work

  1. Biological monitoring of a worker acutely exposed to MBOCA.

    Science.gov (United States)

    Osorio, A M; Clapp, D; Ward, E; Wilson, H K; Cocker, J

    1990-01-01

    A 30 year-old male polyurethane worker was exposed to an accidental spill of 4,4'-methylene-bis-2-chloroaniline (MBOCA) at a plant producing MBOCA-cured plastic products. Exposure to MBOCA is significant in that this compound is a known animal carcinogen and a suspected human carcinogen. The employee was sprayed over his upper body and extremities with molten MBOCA while cleaning out a clogged hose from a MBOCA and polymer mixing machine. The subsequent environmental and medical evaluation of this episode included serial urinary MBOCA samples from the worker over a 2 week period to allow the calculation of a biological half-life for this compound. This worker experienced a very high dose of MBOCA as judged by his urinary MBOCA levels (peak value of 1,700 ppb 4 hours after exposure). There were no acute symptoms or other laboratory abnormalities noted. The kinetic evaluation resulted in a biological half-life for MBOCA in urine of approximately 23 hours. Assuming a one-compartment model, approximately 94% of an initial MBOCA dose will be eliminated within four days. This is the first report of kinetic analysis on urinary MBOCA excretion in humans. This information suggests that biological monitoring of the urine MBOCA concentrations in exposed workers may miss peak levels following an acute exposure unless the analyses of the urinary MBOCA are performed in a timely fashion. Recommendations to the company included: 1) installation of a warning system or lock-out device on the mixing machine to prevent the opening of the MBOCA hose prior to the release of pressure; and 2) annual medical surveillance of this individual for bladder cancer with urinalysis and urine cytology. PMID:2244630

  2. Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde

    International Nuclear Information System (INIS)

    Formaldehyde (FA) is a chemical traditionally used in pathology and anatomy laboratories as a tissue preservative. Several epidemiological studies of occupational exposure to FA have indicated an increased risk of nasopharyngeal cancers in industrial workers, embalmers and pathology anatomists. There is also a clear evidence of nasal squamous cell carcinomas from inhalation studies in the rat. The postulated mode of action for nasal tumours in rats was considered biologically plausible and considered likely to be relevant to humans. Based on the available data IARC, the International Agency for Research on Cancer, has recently classified FA as a human carcinogen. Although the in vitro genotoxic as well as the in vivo carcinogenic potentials of FA are well documented in mammalian cells and in rodents, evidence for genotoxic effects and carcinogenic properties in humans is insufficient and conflicting thus remains to be more documented. To evaluate the genetic effects of long-term occupational exposure to FA a group of 30 Pathological Anatomy laboratory workers was tested for a variety of biological endpoints, cytogenetic tests (micronuclei, MN; sister chromatid exchange, SCE) and comet assay. The level of exposure to FA was evaluated near the breathing zone of workers, time weighted average of exposure was calculated for each subject. The association between the biomarkers and polymorphic genes of xenobiotic metabolising and DNA repair enzymes was also assessed. The mean level of exposure was 0.44 ± 0.08 ppm (0.04-1.58 ppm). MN frequency was significantly higher (p = 0.003) in the exposed subjects (5.47 ± 0.76) when compared with controls (3.27 ± 0.69). SCE mean value was significantly higher (p < 0.05) among the exposed group (6.13 ± 0.29) compared with control group (4.49 ± 0.16). Comet assay data showed a significant increase (p < 0.05) of TL in FA-exposed workers (60.00 ± 2.31) with respect to the control group (41.85 ± 1.97). A positive correlation was

  3. Evoked otoacoustic emissions in workers exposed to noise: A review

    Directory of Open Access Journals (Sweden)

    Alcarás, Patrícia Arruda de Souza

    2012-01-01

    Full Text Available Introduction: The otoacoustic emissions test is an essential tool in the evaluation of auditory function, since it allows the early detection of cochlear damage of occupational origin. Objective: To present a review of the literature and analyze the effectiveness of the clinical application of the otoacoustic emissions test in workers exposed to noise. Methods: A bibliographical search covering a period of 10 years was performed in the Virtual Health Library including published articles in national and international journals indexed in the internationally recognized databases for the health sciences, LILACS, SCIELO, and MEDLINE, using the terms "otoacoustic emissions" and "occupational exposure." The type of published article (national/international, the type and intensity of the stimulus most commonly used for the evoked otoacoustic emissions, the gender and age of the subjects, and the conclusions from the retrospective studies were all taken into consideration. Results and Conclusions: A total of 19 articles were analyzed, 7 national and 12 international, covering subjects from 17 to 77 years of age, mostly men. The type of stimulus most commonly used for the evoked otoacoustic emissions was the distortion method (12. Through this review, we have concluded that testing of evoked otoacoustic emissions in workers exposed to noise is an important tool in the early diagnosis of noise-induced cochlear hearing disorders.

  4. Optimization of radiological surveillance of occupationally-exposed workers in the Republic of Cuba

    International Nuclear Information System (INIS)

    This works analyzes the results of the dosimetric control to occupationally-exposed workers. during the 1987-1990 period. It states a criterium for knowing when it will be necessary to give or not an individual dosimeter to occupationally-exposed workers. It also proposes to take the dosimeter away to a number of workers as a result of such criterium

  5. Monitoring of occupationally exposed workers in a PET-centre

    International Nuclear Information System (INIS)

    A PET-Centre is jointly run with the technical university Dresden (TUD) at the research location Rossendorf. The deployed, short-lived positron emitters are also produced on the location. Apart from the medical applications extensive research projects take place. Workers in this area are occupationally exposed. About 35 persons which are directly involved in the production, processing and application of the radioactive substances, are monitored by official film dosimeters organised by the department of radiation protection-person / Incorporation Surveillance Station. In addition to the workers from the research centre, those operating in the PET-centre of the TUD are routinely monitored by means of operational, self-reading dosimeters, partial-body dosimeters (hands) and incorporation surveillance. The corresponding working areas require well adapted monitoring methods. While direct radiation is the main contributor to the exposure during the production process in the PET-Cyclotron (film dosimeter values), the main attention during the processing and application has to be focussed on partial-body exposure. Investigations on the local distribution of exposure confirmed a conversion factor 2 between dosimeter location and site of greatest exposure as derived in former in previous investigations. Continued repeated operations can cause exposures close to the dose limit of 500 mSv for the hands. According to experiences up to now, incorporations (determined both by random measurements and measurements after interventions, semi-annually at the accelerator) will cause negligible contributions to the exposure in the routine operation. (orig.)

  6. Cytogenetic monitoring of nuclear workers occupationally exposed to ionising radiation

    International Nuclear Information System (INIS)

    Chromosome aberration (CA) analysis using Giemsa techniques was performed in blood lymphocytes of 84 nuclear workers with cumulative doses of 1-632 mSv during employment periods of 1-25 y. The control group comprised 82 healthy male donors. An estimated CA frequency in the total radiation-exposed group was significantly higher when compared with the controls (2.27 vs. 1.76 CA/100 cells, p 0.05). However, significant increase in the total CA frequency was determined in workers with additional internal exposure (2.54 CA/100 cells, p < 0.05) and those with registered neutron doses (2.95 CA/100 cells, p < 0.01). No correlation was found between CA frequency and occupational exposure dose. Borderline significant correlation was found between duration of employment and total CA (r = 0.218, p = 0.046, Fig. 2) and chromosome-type aberration (r = 0.265, p = 0.015) frequency. (authors)

  7. [Targeting abattoirs to control cystic echinococcosis in Algeria].

    Science.gov (United States)

    Benchikh ElFegoun, M C; Kohil, K; L'Ollivier, C; Lleu, M; Babelhadj, B; Piarroux, M; Gharbi, M; Piarroux, R

    2016-08-01

    Cystic echinococcosis (CE) is an important anthropozoonotic parasitic common in Algeria. The predominant life cycle of E. granulosus is a synanthropic cycle with domestic dogs as definitive hosts and livestock animals as intermediate hosts. Slaughter activity represents a potential source for dogs to access infected offal. The aim of the present study was to determine if the contact between dogs and potentially infected offal was possible in licensed abattoirs. Eighty-one private and public abattoirs located in eastern Algeria were assessed with respect to their level of protection against the intrusion of dogs.We have demonstrated that in 42 % of these abattoirs, dogs could easily come in contact with potentially parasitized offal. The most common incorrect practices were the dumping of offal freely into the environment, the feeding of dogs with offal, and the leaving of unattended offal in an unsealed chamber. Overall, some hazardous practices remained common customs of workers, and enough abattoirs remain non-compliant that the cattledog domestic cycle of CE is unlikely to be broken. Hence, some recommended measures to interrupt parasite transmission include the following: recognition of the importance of abattoirs in the maintenance of canine echinococcosis, the controlled and proper disposal of offal, the abolishment of the custom of feeding dogs with infected offal and improvements in the level of health education of abattoir staff. PMID:27251548

  8. Psychophysical Evaluation of Achromatic and Chromatic Vision of Workers Chronically Exposed to Organic Solvents

    International Nuclear Information System (INIS)

    The purpose of this paper was to evaluate achromatic and chromatic vision of workers chronically exposed to organic solvents through psychophysical methods. Thirty-one gas station workers (31.5 ± 8.4 years old) were evaluated. Psychophysical tests were achromatic tests (Snellen chart, spatial and temporal contrast sensitivity, and visual perimetry) and chromatic tests (Ishihara's test, color discrimination ellipses, and Farnsworth-Munsell 100 hue test FM100). Spatial contrast sensitivities of exposed workers were lower than the control at spatial frequencies of 20 and 30 cpd whilst the temporal contrast sensitivity was preserved. Visual field losses were found in 10-30 degrees of eccentricity in the solvent exposed workers. The exposed workers group had higher error values of FM100 and wider color discrimination ellipses area compared to the controls. Workers occupationally exposed to organic solvents had abnormal visual functions, mainly color vision losses and visual field constriction

  9. Psychophysical Evaluation of Achromatic and Chromatic Vision of Workers Chronically Exposed to Organic Solvents

    Directory of Open Access Journals (Sweden)

    Eliza Maria da Costa Brito Lacerda

    2012-01-01

    Full Text Available The purpose of this paper was to evaluate achromatic and chromatic vision of workers chronically exposed to organic solvents through psychophysical methods. Thirty-one gas station workers (31.5 ± 8.4 years old were evaluated. Psychophysical tests were achromatic tests (Snellen chart, spatial and temporal contrast sensitivity, and visual perimetry and chromatic tests (Ishihara's test, color discrimination ellipses, and Farnsworth-Munsell 100 hue test—FM100. Spatial contrast sensitivities of exposed workers were lower than the control at spatial frequencies of 20 and 30 cpd whilst the temporal contrast sensitivity was preserved. Visual field losses were found in 10–30 degrees of eccentricity in the solvent exposed workers. The exposed workers group had higher error values of FM100 and wider color discrimination ellipses area compared to the controls. Workers occupationally exposed to organic solvents had abnormal visual functions, mainly color vision losses and visual field constriction.

  10. Pulmonary nodules in workers exposed to urban stressor

    Energy Technology Data Exchange (ETDEWEB)

    Sancini, A. [University of Rome ' Sapienza' , Department of Occupational Medicine, Viale Regina Elena 336, 00161 Rome (Italy); Fioravanti, M. [University of Rome ' Sapienza' , Department of Psychiatric Science and Psychological Medicine, Piazzale Aldo Moro 5, 00185 Rome (Italy); Ciarrocca, M.; Palermo, P.; Fiaschetti, M.; Schifano, M.P. [University of Rome ' Sapienza' , Department of Occupational Medicine, Viale Regina Elena 336, 00161 Rome (Italy); Tomei, G. [University of Rome ' Sapienza' , Department of Psychiatric Science and Psychological Medicine, Piazzale Aldo Moro 5, 00185 Rome (Italy); Tomei, F., E-mail: francesco.tomei@uniroma1.it [University of Rome ' Sapienza' , Department of Occupational Medicine, Viale Regina Elena 336, 00161 Rome (Italy)

    2010-07-15

    By multilayer spiral low-dose computed tomography (LD-CT) of the chest this study assesses the early detection of lung lesions on a sample of 100 traffic policemen of a big Italian city professionally exposed to urban pollutants and 100 controls non-occupationally exposed to urban pollutants matched by sex, age, length of service and cigarette smoking habit. Exposure to urban pollutants in traffic policemen was characterized using the annual average concentrations of PM{sub 10}, NO{sub 2} and benzene in the period 1998-2008 measured by fixed monitoring stations located in different areas of the city. A significant and increasing number of suspicious lung nodules with diameters between 5 and 10 mm was observed: in traffic policemen (including smokers and non-smokers) vs. controls (including smokers and non-smokers); in total smokers (including traffic policemen and controls) vs. total non-smokers (traffic policemen and controls); in smoker traffic policemen vs. smoker controls and vs. non-smoker traffic policemen; in non-smoker traffic policemen vs. non-smoker controls. The RR of finding cases with at least one lung nodule with diameters between 5 and 10 mm in traffic policemen (including smokers and non-smokers) compared to controls (including smokers and non-smokers) is 1.94 (CI 1.13-3.31); in total smokers vs. non-smokers the RR is 1.96 (CI 1.20-3.19). The comparison between the interaction exposure and smoking shows an increase in smoker traffic policemen than in smoker controls (RR=2.14; CI 1.02-4.52). The RR for smoker traffic policemen was higher than in non-smoker traffic policemen (RR=2.09; CI 1.19-3.66). The results of our study show that: (1) while smoker workers have a higher risk for developing solid suspicious lung nodules, the simple routinely exposure to urban pollutants is unable to produce the same kind of increased risk; (2) the interaction of smoking and exposure to urban pollutants greatly increases the risk for the development of solid

  11. Coal worker's pneumoconiosis: CT assessment in exposed workers and correlation with radiographic findings

    International Nuclear Information System (INIS)

    To study the signs of coal worker's pneumoconiosis (CWP) at computed tomography (CT), the authors obtained thoracic CT scans in 170 coal-dust-exposed workers who were concomitantly evaluated with conventional posteroanterior and lateral radiography. The profusion and extent of disease was assessed by means of CT in two groups of miners: group 1 (n = 86), miners with worker's compensation and radiographic evidence of CWP, and group 2(n = 84), miners who had applied for compensation without radiographic evidence of CWP. The CT signs of CWP consisted of micronodules, nodules, and progressive massive fibrosis. The comparative analysis demonstrates the superiority of an optimal CT technique over chest radiography in the evaluation of simple silicosis, with improved sensitivity in the detection of small parenchymal opacities. CT provides additional information on the stage of the disease but also clarifies some ambiguities of the ILO classification of small opacities. CT was equivalent to radiography for complicated silicosis, except in the identification of necrosis. CT evaluations are complementary to plain radiography in the assessment of CWP, and the addition of high-resolution CT is useful in achieving a more accurate evaluation of the small parenchymal opacities

  12. Genetic monitoring of aluminum workers exposed to coal tar pitch volatiles.

    Science.gov (United States)

    Heussner, J C; Ward, J B; Legator, M S

    1985-03-01

    A group of 50 workers exposed to coal tar pitch volatiles (CTPV) in an aluminum reduction plant and a group of 50 non-exposed workers were selected to evaluate the genotoxic effects of CTPV exposure. A battery of tests was performed on 3 different body fluids; urine, blood and semen. Urine samples were evaluated for mutagenic constituents using the Ames/Salmonella assay. Cultured lymphocytes from blood samples were used to perform cytogenetic analysis. Semen samples were used to measure sperm count, percent abnormal sperm morphology and frequency of sperm carrying double fluorescent bodies (2-F). 14 of 28 (50%) exposed workers and 7 of 36 (19.4%) non-exposed workers had mutagenic urine. This difference was significant (p less than 0.01). Among the non-smokers a significantly higher percentage of workers who were exposed had positive urine (36%) compared to the non-exposed workers (5%) (p less than 0.05). Among the exposed group, more mechanics had mutagenic urine than did other types of workers. Overall chromosome aberration rates were similar in both exposed and non-exposed workers. Among exposed workers a significant inverse correlation (p less than 0.05) between age and chromatid aberration rate was observed. Results of semen analysis failed to detect differences between exposed and non-exposed workers. Results of these tests lend support to a battery approach to genetic monitoring and suggest a link between exposure to CTPV and genotoxic effects. Detection of exposure to mutagens at an early time offers an opportunity for disease prevention by the reduction of exposure.

  13. The management of workers occupationally exposed to ionizing radiation

    International Nuclear Information System (INIS)

    In Canada, the regulation of radiation protection is a shared responsibility between the federal body (the Atomic Energy Control Board) and the appropriate provincial body (usually the Department of Health, or Department of Labour). The AECB is responsible, for example, for regulating the development, application and use of nuclear energy and radioisotopes, and the provinces are responsible for the regulation of all other forms of ionizing and non-ionizing radiations and for naturally-occurring radioactive material (NORM). Although there is consultation between the federal and provincial regulatory agencies, the division of jurisdictional authority has resulted in considerable differences in the approach towards implementation radiation protection programs in Canada. This is especially true in the management of workers occupationally exposed to ionizing radiation. These differences have produced unwarranted discrepancies in operating procedures and practices in the allocation of resources and manpower, and in the requirements governing radiological training, personnel monitoring and medical surveillance. In light of the General Amendments to the AEC Regulations, the 1990 Recommendations of the ICRP, and the IAEA recommendations on safety culture, the ACRP has considered it timely to undertake a study to examine the feasibility of establishing a more coherent approach to harmonize radiation protection practices within Canada. This study comprised an examination of the regulatory approach used in several countries: a review of the nature of radiation safety programs in various types of licensed institutions and facilities in Canada; and a review of recommendations of internationally-recognized authorities in radiation protection

  14. Forestry workers exposed to vibration: a neurological study.

    OpenAIRE

    Färkkilä, M; Pyykkö, I; Jäntti, V. (Ville); Aatola, S; Starck, J; Korhonen, O.

    1988-01-01

    Neurological findings were examined in 186 forestry workers with a mean exposure to chain saw vibration of 16.6 hours. The prevalence of active vibration induced white fingers was 5%, parethaesias of the hands 53%, and muscle weakness 13%. Clinical polyneuropathy was observed in 16 forestry workers in the hands (7.5%) which did not correlate with alcohol consumption. Seventy nine forestry workers of the total population were selected for electromyographic examination. Generalised EMG based po...

  15. Immunologic Response of Unvaccinated Workers Exposed to Anthrax, Belgium

    OpenAIRE

    Wattiau, Pierre; Govaerts, Marc; Frangoulidis, Dimitrios; Fretin, David; Kissling, Esther; Van Hessche, Mieke; China, Bernard; Poncin, Martine; Pirenne, Yvo; Hanquet, Germaine

    2009-01-01

    To determine immunologic reactivity to Bacillus anthrax antigens, we conducted serologic testing of workers in a factory that performed scouring of wool and goat hair. Of 66 workers, ≈10% had circulating antibodies or T lymphocytes that reacted with anthrax protective antigen. Individual immunity varied from undetectable to high.

  16. Epidemiologic Study of One Million American Workers and Military Veterans Exposed to Ionizing Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Boice, John D.

    2015-02-27

    A pilot study was completed demonstrating the feasibility of conducting an epidemiologic study assessing cancer and other disease mortality among nearly one million US veterans and workers exposed to ionizing radiation, a population 10 times larger than atomic bomb survivor study with high statistical power to evaluate low dose rate effects. Among the groups enumerated and/or studied were: (1) 194,000 Department of Energy Uranium Workers; (2) 6,700 Rocketdyne Radiation Workers; (3) 7,000 Mound Radiation Workers; (4) 156,000 DOE Plutonium Workers; (5) 212,000 Nuclear Power Plant Workers; (6) 130,000 Industrial Radiography Workers; (7) 1.7 million Medical Workers and (8) 135,000 Atomic Veterans.

  17. Persistent symptoms in agricultural workers exposed to organophosphate pesticides

    Directory of Open Access Journals (Sweden)

    Martha E. Palacios N

    2011-07-01

    Full Text Available Objective: to evaluate the prevalence of these symptoms and their relationship with pesticide exposure and the cholinesterase levels in agricultural workers. Methodology: an analytical cross-sectional study conducted in Mexico. Cholinesterase concentration and symptom frequency were assessed for 106 agricultural workers. Exposure was defined with a composed index of 15 variables. Results: symptom prevalence was 52 out of 100 workers. 31% of workers had 1 to 3 of the symptoms, 16% had 4 to 9 of them and 5% had 10 or more of the symptoms. There was an association, p = 0.03, between days of exposure and persistent symptoms. Likewise, there was an association between exposure level and the presence of probable and specific symptoms. Patients with the highest exposure level had 20% more chances of exhibiting symptoms. Cholinesterase concentration ranges were normal. Anemia was detected in 28% of the population. It was three times as frequent in females as in males (p < 0.001. Conclusions: it was possible to identify the increase of persistent symptoms in workers with cholinesterase levels that are usually considered to be normal.

  18. Prolonged menstrual cycles in female workers exposed to ethylene glycol ethers in the semiconductor manufacturing industry

    OpenAIRE

    Hsieh, G; Wang, J.; CHENG, T.; Chen, P.

    2005-01-01

    Background: It has been shown that female workers exposed to ethylene glycol ethers (EGEs) in the semiconductor industry have higher risks of spontaneous abortion, subfertility, and menstrual disturbances, and prolonged waiting time to pregnancy.

  19. Respiratory Symptoms and Lung Function in Never-Smoking Male Workers Exposed To Hardwood Dust

    Directory of Open Access Journals (Sweden)

    Dragana Bislimovska

    2015-07-01

    CONCLUSION: Our data suggest that workplace exposure to hardwood dust may lead to adverse respiratory effects indicating the need of adequate preventive measures in order to protect the respiratory health of exposed workers.

  20. Lung Function Status of Workers Exposed to Welding Fume: A Preliminary Study

    OpenAIRE

    Mulyana Mulyana; Nuri Purwito Purwito Adi; Meily L Kurniawidjaja; Andi Wijaya; Irawan Yusuf

    2016-01-01

    BACKGROUND: Exposure to welding fume in the workplace was associated with lung function disorders and occupational asthma. In this study, we determined lung function parameters in men workers exposed to welding fumes from heavy equipment manufacturer. This study is a preliminary study of biomonitoring program in worker exposed to welding fume as our main study. METHODS: A study with case-control design, random study, was conducted among welder (59 subjects) and non-welder (34 subjects) wi...

  1. Subclinical interstitial lung damage in workers exposed to indium compounds

    OpenAIRE

    Choi, Sungyeul; Won, Yong-Lim; Kim, Dohyung; Yi, Gwang-Yong; Park, Jai-Soung; Kim, Eun-A

    2013-01-01

    Objectives The present study was designed to determine whether there is a relationship between indium compound exposure and interstitial lung damage in workers employed at indium tin oxide manufacturing and reclaiming factories in Korea. Methods In 2012, we conducted a study for the prevention of indium induced lung damage in Korea and identified 78 workers who had serum indium or Krebs von den Lungen-6 (KL-6) levels that were higher than the reference values set in Japan (3 μg/L and 500 U/mL...

  2. Cytogenetic analysis of an exposed-referent study: perchloroethylene-exposed dry cleaners compared to unexposed laundry workers

    Directory of Open Access Journals (Sweden)

    McKernan Lauralynn

    2011-03-01

    Full Text Available Abstract Background Significant numbers of people are exposed to tetrachloroethylene (perchloroethylene, PCE every year, including workers in the dry cleaning industry. Adverse health effects have been associated with PCE exposure. However, investigations of possible cumulative cytogenetic damage resulting from PCE exposure are lacking. Methods Eighteen dry cleaning workers and 18 laundry workers (unexposed controls provided a peripheral blood sample for cytogenetic analysis by whole chromosome painting. Pre-shift exhaled air on these same participants was collected and analyzed for PCE levels. The laundry workers were matched to the dry cleaners on race, age, and smoking status. The relationships between levels of cytological damage and exposures (including PCE levels in the shop and in workers' blood, packyears, cumulative alcohol consumption, and age were compared with correlation coefficients and t-tests. Multiple linear regressions considered blood PCE, packyears, alcohol, and age. Results There were no significant differences between the PCE-exposed dry cleaners and the laundry workers for chromosome translocation frequencies, but PCE levels were significantly correlated with percentage of cells with acentric fragments (R2 = 0.488, p Conclusions There does not appear to be a strong effect in these dry cleaning workers of PCE exposure on persistent chromosome damage as measured by translocations. However, the correlation between frequencies of acentric fragments and PCE exposure level suggests that recent exposures to PCE may induce transient genetic damage. More heavily exposed participants and a larger sample size will be needed to determine whether PCE exposure induces significant levels of persistent chromosome damage.

  3. Respiratory function in female workers occupationally exposed to organic dusts in food processing industries.

    Science.gov (United States)

    Zuskin, E; Mustajbegović, J; Schachter, E N; Kern, J; Ivanković, D; Heimer, S

    2000-01-01

    Respiratory consequences of work in food processing industry were studied in 764 female workers exposed to organic dusts associated with the processing of green and roasted coffee, tea, spices, dried fruits, cocoa and flour. A group of 387 female workers not exposed to respiratory irritants served as controls for the prevalence of acute (during work shift) and chronic respiratory symptoms. A greater prevalence of all acute and chronic respiratory symptoms was consistently found among exposed workers than among control workers. The highest prevalence of chronic respiratory symptoms was recorded for chronic cough (40%), followed by acute symptoms of dry cough (58.7%). The difference in the prevalence of chronic respiratory symptoms between the exposed and control workers was in general significant (p DSCG) significantly diminished across-shift reductions for FEF50 and FEF25 in a subgroup of the examined workers. Our data suggested the female workers employed in food processing industry to be at risk of developing both acute and chronic respiratory symptoms as well as ventilatory capacity impairment as the result of occupational exposures. PMID:11379483

  4. Neurological dysfunction of the bladder in workers exposed to dimethylaminopropionitrile.

    Science.gov (United States)

    Kreiss, K; Wegman, D H; Niles, C A; Siroky, M B; Krane, R J; Feldman, R G

    Neurogenic bladder dysfunction, characterized by hesitancy, need to strain, decreased stream, and increased duration of urination, developed in 104 (63%) of 166 employees working in the manufacture of polyurethane foam. Highest rates of illness (69%) occurred in production workers, and no illness occurred in office or warehouse workers. Onset of the epidemic coincided with introduction of a catalyst, dimethylaminopropionitrile (DMAPN), and monthly case incidence rates increased as DMAPN use increased. Outbreak ceased abruptly when DMAPN use was stopped. Of eight patients who underwent neurourologic testing during recovery, seven lacked either detrusor reflex or normal sensation of bladder filling; seven had a subclinical sensory abnormality; three had prolonged sacral-evoked responses; and two of these three had limb motor neuropathies. Dimethylaminopropionitrile is unique among known neurotoxins in producing urinary symptoms more frequently than limb nerve symptoms. PMID:6243373

  5. Dose constraints to the individual annual doses of exposed workers in nuclear medicine laboratories

    International Nuclear Information System (INIS)

    The study deals with the analysis of dose distribution records of the occupationally exposed workers in the field of nuclear medicine in Greece and the establishment of constraints to their individual annual doses (IAD) within the process of optimization in radiation protection. The exposed workers were grouped according to their specialties (medical doctors, technicians, others), the kind of services provided (diagnosis or diagnosis plus I-131 therapy) and the sector they belonged (public or private). Dose constraints (DC) were set at the level below which the IAD of the 75% of the exposed workers per specialty were included. Our results showed that DC levels were exceeded by the 13% of the exposed workers in the public and the 30% in the private sector respectively. Further investigation indicated that the reasons leading to the exceeding of DCs, may be attributed to the workload of the exposed workers which is greater in the private than in the public sector as well as, to possible difference in the specific tasks of workers between the two sectors. (author)

  6. Clinical, cytogenetic and toxicological studies in rural workers exposed to pesticides in Botucatu, São Paulo, Brazil

    OpenAIRE

    Salete Marcia Bréga; Igor Vassilieff; Alaor Almeida; Amauri Mercadante; Denise Bissacot; Paulo R. Cury; Dertia V. Freire-Maia

    1998-01-01

    Pesticides can cause gene mutations and chromosomal aberrations in exposed individuals. We have investigated 24 workers exposed to pesticides. Clinical examinations and cytogenetic and toxicological tests were performed. Ten non-exposed individuals were used as controls. Toxicological dosages of copper, zinc and manganese (metals found in some pesticides), hepatic enzyme dosage (GOT, GPT, AR) and acetylcholinesterase activity were performed in 16 workers and 8 controls. In the exposed workers...

  7. Food safety knowledge and practices of abattoir and butchery shops and the microbial profile of meat in Mekelle City, Ethiopia

    Institute of Scientific and Technical Information of China (English)

    Mekonnen Haileselassie; Habtamu Taddele; Kelali Adhana; Shewit Kalayou

    2013-01-01

    Objective: To assess the food safety knowledge and practices in meat handling, and to determine microbial load and pathogenic organisms in meat at Mekelle city. Methods: A descriptive survey design was used to answer questions concerning the current status of food hygiene and sanitation practiced in the abattoir and butcher shops. Workers from the abattoir and butcher shops were interviewed through a structured questionnaire to assess their food safety knowledge. Bacterial load was assessed by serial dilution method and the major bacterial pathogens were isolated by using standard procedures. Results: 15.4% of the abattoir workers had no health certificate and there was no hot water, sterilizer and cooling facility in the abattoir. 11.3% of the butchers didn't use protective clothes. There was a food safety knowledge gap within the abattoir and butcher shop workers. The mean values of bacterial load of abattoir meat, butcher shops and street meat sale was found to be 1.1×105, 5.6×105 and 4.3×106 cfu/g, respectively. The major bacterial pathogens isolated were Escherichia coli, Staphylococcus aureus and Bacillus cereus. Conclusions: The study revealed that there is a reasonable gap on food safety knowledge by abattoir and butcher shop workers. The microbial profile was also higher compared to standards set by World Health Organization. Due attention should be given by the government to improve the food safety knowledge and the quality standard of meat sold in the city.

  8. Urinary mutagenic activity in workers exposed to diesel exhaust

    Energy Technology Data Exchange (ETDEWEB)

    Schenker, M.B.; Samuels, S.J.; Kado, N.Y. (Univ. of California, Davis (United States)); Hammond, S.K.; Woskie, S.R.; Smith, T.J. (Univ. of Massachusetts, Worcester (United States))

    1992-04-01

    The authors measured postshift urinary mutagenicity on a population of railroad workers with a range of diesel exhaust exposures. Postshift urinary mutagenicity was determined by a sensitive microsuspension procedure using Salmonella strain TA 98 {plus minus} S9. Number of cigarettes smoked on the study day and urinary cotinine were highly correlated with postshift urinary mutagenicity. Diesel exhaust exposure was measured over the work shift by constant-flow personal sampling pumps. The relative ranking of jobs by this adjusted respirable particle concentration (ARP) was correlated with relative contact the job groups have with operating diesel locomotives. After adjustment for cigarette smoking in multiple regressions, there was no independent association of diesel exhaust exposure, as estimated by ARP, with postshift urinary mutagenicity among smokers or nonsmokers. An important finding is the detection of baseline mutagenicity in most of the nonsmoking workers. Despite the use of individual measurements of diesel exhaust exposure, the absence of a significant association in this study may be due to the low levels of diesel exposure, the lack of a specific marker for diesel exhaust exposure, and/or urinary mutagenicity levels from diesel exposure below the limit of sensitivity for the mutagenicity assay.

  9. Assessment of functional integrity of liver among workers exposed to soluble nickel compounds during nickel plating

    Directory of Open Access Journals (Sweden)

    Kalahasthi Ravi Babu

    2006-01-01

    Full Text Available The present study investigates the functional integrity of liver among workers exposed to nickel during nickel-plating process. The functional integrity of liver was assessed in 69 workers who are exposed to nickel during nickel plating and considered as nickel-exposed workers; and 50 administrative workers residing in same city, but away from the place of work of study group, were considered as control group. The level of urine nickel was measured by using a flameless atomic absorption spectrophotometer. Using kits supplied by Bayer Diagnostics, we determined serum markers of liver function tests. Results: The levels of urine nickel were significantly increased in high-and moderate-exposure groups as compared to control group. The levels of serum transaminases -viz, alanine transaminase and aspartate transaminase-were significantly increased in nickel-exposed workers, who had high urine nickel levels as compared to control group. The level of serum albumin was negatively correlated with urine nickel levels. The levels of serum transaminases and serum g- glutamyl- transpeptidase were positively and significantly correlated with urine nickel levels. Conclusion: Results indicate that workers who had high urine nickel levels had a consistent effect on hepatic inflammatory function.

  10. [Hematologic changes in workers exposed to radio wave radiation].

    Science.gov (United States)

    Budinscak, V; Goldoni, J; Sarić, M

    1991-12-01

    Haematological parameters were measured in 43 radar operators employed in air traffic control occupationally exposed to microwave radiation of low intensity over a period of four years. Exposure to heat, soft X-ray radiation and noise were within maximally allowed limits. The haematological changes included a decreased number of erythrocytes, reticulocytes, platelets, segmented granulocytes and monocytes, and an increased number of leucocytes and lymphocytes. The changes were not pathologically significant and most of them were reversible.

  11. Psychophysical Evaluation of Achromatic and Chromatic Vision of Workers Chronically Exposed to Organic Solvents

    OpenAIRE

    Luiz Carlos de Lima Silveira; Dora Fix Ventura; Lauro José Barata de Lima; Cláudio Eduardo Correa Teixeira; Anderson Raiol Rodrigues; Eliza Maria da Costa Brito Lacerda; Monica Gomes Lima

    2012-01-01

    The purpose of this paper was to evaluate achromatic and chromatic vision of workers chronically exposed to organic solvents through psychophysical methods. Thirty-one gas station workers (31.5 ± 8.4 years old) were evaluated. Psychophysical tests were achromatic tests (Snellen chart, spatial and temporal contrast sensitivity, and visual perimetry) and chromatic tests (Ishihara's test, color discrimination ellipses, and Farnsworth-Munsell 100 hue test—FM100). Spatial contrast sensitivities of...

  12. [Borderline mental disorders in workers exposed to poisons and their prevention].

    Science.gov (United States)

    Filippov, V L

    1997-01-01

    Studies covered psychic state in workers exposed to poisons. The authors represent clinical and epidemiologic principles of the disorders formation, the prevalence and structure of the disorders caused by various hazards. The article necessitates up-to-date data-processing system for occupational selection, clinical, psychophysiologic, biochemical and experimental psychologic evaluation of current state in workers engaged into liquidation of chemical weapons. PMID:9377033

  13. Influence of Some Pesticides on Humoral and Cellular Immunity of Exposed Workers in Pesticides Industries

    International Nuclear Information System (INIS)

    Pesticide poisoning is a major public health problem in developing countries. In most of these countries organophosphate pesticides constitute the most widely used pesticides. The main toxicity of OPs is neurotoxicity, which is caused by the inhibition of acetylcholinesterase. OPs also affect the immune response, including effects on cellular and humoral immunity. Our study examined the effect of organophosphorus compounds on humoral and cellular immunity of exposed workers in pesticides industries. The study was conducted into 40 subjects. They were 2 groups; 20 exposed workers from Gharbeia and Kafr Elsheikh at 2008 and 2009 and 20 unexposed individuals as a control group at the same period of time. We examined some immune parameters; pseudocholinesterase, WBCs count, CD4%, CD8%, CD4/CD8, CD56%, Interleukin 2, IgG and IgM. Also we take history and clinical examination for them. We reported a highly significant decrease in pseudo cholinesterase level among the exposed group in comparison to the control group, highly significant increase in percentage of CD8 in the exposed group in comparison to control group, highly significant decrease in CD4 / CD8 ratio in the exposed group in comparison to control group, highly significant decrease in percentage of CD56 in the exposed group in comparison to control group and a highly significant increase in IgG level in the exposed group in comparison to control group. On the other hand, we reported no significant change in white blood cells count between the exposed and control groups, no significant change in percentage of CD4 among the exposed and control group, no significant change in Interleukin 2 level among the exposed and control group and no significant change in IgM level among the exposed and control group. We concluded that pesticides extensively affect the humoral and cellular immune system of occupationally exposed workers.

  14. DNA damage in leukocytes of workers occupationally exposed to arsenic in copper smelters.

    Science.gov (United States)

    Palus, Jadwiga; Lewinska, Dobroslawa; Dziubaltowska, Elzbieta; Stepnik, Maciej; Beck, Jens; Rydzynski, Konrad; Nilsson, Robert

    2005-08-01

    Inorganic arsenic (i-As) is a known human carcinogen; however, humans continue to be exposed to i-As in drinking water and in certain occupational settings. In this study, we used the Comet assay to evaluate DNA damage in the somatic cells of workers from three Polish copper smelters who were occupationally exposed to i-As. Blood samples were collected from 72 male workers and 83 unexposed male controls and used for the detection of DNA damage, oxidative DNA damage, and DNA damage after a 3-hr incubation in culture. Urine samples were collected to assess the level of exposure. The mean concentration of arsenic metabolites in urine [the sum of arsenite (AsIII), arsenate (AsV), monomethylarsenate (MMA) and dimethylarsenate (DMA)] and the concentrations of DMA (the main metabolite in urine) were higher in workers than in controls, but the differences were not statistically significant. By contrast, the level of DNA damage, expressed as the median tail moment, was significantly higher in the leukocytes of workers than in the controls. Comet assays conducted with formamidopyrimidine glycosylase (FPG) digestion to detect oxidative DNA damage indicated that oxidative lesions were present in leukocytes from both the exposed and control groups, but the levels of damage were significantly higher among the workers. Incubation of the cells in culture resulted in a significant reduction in the levels of DNA damage, especially among leukocytes from the workers, suggesting that the DNA damage was subject to repair. Our findings indicate that copper smelter workers have increased levels of DNA damage in somatic cells, suggesting a potential health risk for the workers. Although i-As was present in air samples from the smelters and in urine samples from workers, no clear association could be made between i-As exposure and the DNA damage. PMID:15880732

  15. Asthma Symptoms and Specific IgE Levels among Toluene Diisocyanate (TDI Exposed Workers in Tehran, Iran

    Directory of Open Access Journals (Sweden)

    Laleh Sharifi

    2013-04-01

    Full Text Available Background: Toluene diisocyanate (TDI is an imperative chemical substance used in the production of polyurethane foams, elastomers, paints and coatings that cause a variety of health problems in workers who are exposed in work places. This study aimed to determine the asthma symptoms and serum specific IgE levels in TDI exposed workers and comparing the results with healthy control group.Methods: All the plants that use TDI in the manufacturing of paint and glue in the west of Tehran Province entered to the study and all the workers (550 completed modified initial questionnaire of the NIOSH, the questions were consisted of asthma symptoms. For each symptomatic exposed worker one healthy, sex and age matched control selected. Total IgE and Specific TDI IgE tests were done for each case and control groups.Results: Among 550 TDI exposed workers, 26(4.7% had asthma symptoms. Nine (34.6% of symptomatic workers who were exposed to TDI were active cigarette consumer versus 3(11.5% unexposed workers, P=0.049(CI= 0.953-17.29 OR=4.059. Nine (34.6% workers had positive family history of atopy versus 1(3.8% unexposed workers, P=0.0138 (CI= 1.45-305.41 OR=13.24. TDI specific IgE was found in 2 TDI exposed workers and 1 unexposed worker (P=0.5. Mean of total IgE was 339.05 in exposed workers (P=0.201.Conclusion: This study provides clinical and paraclinical data of workers exposed to TDI and points to a relation between atopy and smoking habit with asthma symptoms that offer preventing recommendations for TDI exposed workers and their heath administrators.

  16. Lymphocyte reactivity of workers exposed to carcinogenic and non-carcinogenic chemicals.

    OpenAIRE

    Kumar, S.; Taylor, G; Hurst, W; Wilson, P.; Costello, C B

    1981-01-01

    Immunological studies have shown an increased lymphocyte reactivity in patients with early stage bladder cancer and individuals with pre-stage T1 exposed to bladder carcinogens (2-naphthylamine and industrial 1-naphthylamine containing 4-8% 2-naphthylamine) before 1952-that is, those at high risk of developing bladder cancer. Because of the close chemical similarity of Tobias acid (2-naphthylamine-1 sulphonic acid) to 2-naphthylamine, the lymphocytotoxicity of workers exposed to this chemical...

  17. Mortality among a cohort of garment workers exposed to formaldehyde: an update

    OpenAIRE

    Pinkerton, L; Hein, M.; Stayner, L

    2004-01-01

    Aims: To evaluate the mortality experience of 11 039 workers exposed to formaldehyde for three months or more in three garment plants. The mean time weighted average formaldehyde exposure at the plants in the early 1980s was 0.15 ppm but past exposures may have been substantially higher.

  18. Handling of indicators in the evaluation of the medical monitoring in workers occupational exposed

    International Nuclear Information System (INIS)

    The present time the medical surveillance of exposed workers is an active surveillance of the adverse effect associated with radiation exposure. The purpose of this paper is to propose indices of the effectiveness and effect of the occupational service and activity from evaluation of the medical surveillance. (author)

  19. Dose constraints to the individual annual doses of exposed workers in the medical sector

    Energy Technology Data Exchange (ETDEWEB)

    Kamenopoulou, V. E-mail: titika@eeae.nrcps.ariadne-t.gr; Drikos, G.; Dimitriou, P

    2001-03-01

    The study is an attempt, within the process of the optimization of radiation protection, to propose constraints to the individual annual doses of classified workers employed in the medical sector of ionizing radiation applications in Greece. These exposed workers were grouped according to their specialties, i.e. medical doctors, technicians and nurses and their occupational category with common or similar tasks, such as diagnostic radiology, interventional radiology, nuclear medicine and radiotherapy. The last 5 years' annual dose distributions of these occupational groups, coming from the National Dose Registry Information System (NDRIS) of the Greek Atomic Energy Commission (GAEC) were analyzed. The proposed dose constraints (DCs) were set at levels, below which the annual doses of the 70 or 75% of the exposed workers per category are expected to be included. At the present stage the derived values may be considered achievable ceiling values referring to acceptably applied practices rather than to optimized ones, taking into account social and economic criteria.

  20. Estimation of cytogenetic risk among coke oven workers exposed to polycyclic aromatic hydrocarbons.

    Science.gov (United States)

    Sureshkumar, Shanmugam; Balachandar, Vellingiri; Devi, Subramaniam Mohana; Arun, Meyyazhagan; Karthickkumar, Alagamuthu; Balamuralikrishnan, Balasubramanian; Sankar, Kathannan; Mustaqahamed, Shafi Ahammed Khan; Dharwadkar, Shanwaz N; Sasikala, Keshavarao; Cho, Ssang-Goo

    2013-01-01

    Polycyclic aromatic hydrocarbons (PAHs) result from the incomplete combustion of natural or synthetic organic materials. The working environment at a coke plant can negatively affect the employed workers who were exposed to coke oven emissions containing PAHs, which formed and released into the environment by the process of pyrolysis of coke. This study aims to analyze the relationship between the exposure of PAHs and the risk of genetic damages such as chromosomal alteration (CA), micronucleus (MN), and DNA damage (PCR-RFLP) in peripheral blood lymphocytes of 27 coke oven workers and equal number of control subjects. The exposed subjects and controls were divided into two groups based on their age (group Icoke oven workers under risk should be monitored for adverse effects of the any long-term exposure. PMID:24040626

  1. Study of External Radiation Expose Dose on Hands of Nuclear Medicine Workers

    International Nuclear Information System (INIS)

    The aims of this study are to assess external radiation exposed doses of body and hands of nuclear medicine workers who handle radiation sources, and to measure radiation exposed doses of the hands induced by a whole body bone scan with high frequency and handling a radioactive sources like 99mTc-HDP and 18F-FDG in the PET/CT examination. Skillful workers, who directly dispense and inject from radiation sources, were asked to wear a TLD on the chest and ring finger. Then, radiation exposed dose and duration exposed from daily radiation sources for each section were measured by using a pocket dosimeter for the accumulated external doses and the absorbed dose to the hands. In the survey of four medical institutions in Incheon Metropolitan City, only one of four institutions has a radiation dosimeter for local area like hands. Most of institutions uses radiation shielding devices for the purpose of protecting the body trunk, not local area. Even some institutions were revealed not to use such a shielding device. The exposed doses on the hands of nuclear medicine workers who directly handles radioactive sources were approximately twice as much as those on the body. The radiation exposure level for each section of the whole body bone scan with high frequency and that of the PET/CT examination showed that radiation doses were revealed in decreasing order of synthesis of radioactive medicine and installation to a dispensing container, dispensing, administering and transferring. Furthermore, there were statistically significant differences of radiation exposure doses of the hands before and after wearing a syringe shielder in administration of a radioactive sources. In this study, although it did not reach the permissible effective dose for nuclear medicine, the occupational workers were exposed by relatively higher dose level than the non-occupational workers. Therefore, the workers, who closely exposed to radioactive sources should be in compliance with safety management

  2. Whole-body measurements of workers occupationally exposed to radionuclides at IPEN/CNEN-SP

    Energy Technology Data Exchange (ETDEWEB)

    Cardoso, Joaquim Carlos S.; Xavier, Marcos, E-mail: jcardoso@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2015-07-01

    The intake of radioactive material by workers can occur in the radiopharmaceuticals production, during the handling of these in the medical fields (nuclear medicine) and in biological and research laboratories. The workers who work in areas where exposures are significant are routinely monitored to demonstrate that the workers are receiving adequate protection from internal contamination. Direct measurements of whole-body and thyroid contents provide an estimate of the activity of these radionuclides in the potentially exposed workers. The whole-body measurements of the workers, trainees and visitors are routinely performed by the In Vivo Monitoring Laboratory (LMIV) of the Energy and Nuclear Research Institute (IPEN/CNEN-SP). The frequency of measurements is defined by the Radioprotection Service (SRP) and the Dose Calculation Group of IPEN. For this purpose LMIV has two counters, whole body. NaITl (8 x 4”), and thyroid one, NaITl (3 x 3”). The system was calibrated in energy and efficiency, with calibration sources of Eu-152, Am-241 and Co-60 with gamma emissions between 59.54 and 1408.08 keV, positioned within Alderson Research Labs. anthropomorphic phantom. The background measures were obtained of worker's spectrum that was not exposed occupationally yet. The concepts adopted in the HPS N13.30 Standard and proposed in ISO documents for standardization were used for activity measurements. During the period January 2010 to December 2014, approximately 4500 measurements had been carried in workers who develop tasks related to the production and research. The activities of the radionuclides and the workers' tasks relationship had been evaluated. (author)

  3. Whole-body measurements of workers occupationally exposed to radionuclides at IPEN/CNEN-SP

    International Nuclear Information System (INIS)

    The intake of radioactive material by workers can occur in the radiopharmaceuticals production, during the handling of these in the medical fields (nuclear medicine) and in biological and research laboratories. The workers who work in areas where exposures are significant are routinely monitored to demonstrate that the workers are receiving adequate protection from internal contamination. Direct measurements of whole-body and thyroid contents provide an estimate of the activity of these radionuclides in the potentially exposed workers. The whole-body measurements of the workers, trainees and visitors are routinely performed by the In Vivo Monitoring Laboratory (LMIV) of the Energy and Nuclear Research Institute (IPEN/CNEN-SP). The frequency of measurements is defined by the Radioprotection Service (SRP) and the Dose Calculation Group of IPEN. For this purpose LMIV has two counters, whole body. NaITl (8 x 4”), and thyroid one, NaITl (3 x 3”). The system was calibrated in energy and efficiency, with calibration sources of Eu-152, Am-241 and Co-60 with gamma emissions between 59.54 and 1408.08 keV, positioned within Alderson Research Labs. anthropomorphic phantom. The background measures were obtained of worker's spectrum that was not exposed occupationally yet. The concepts adopted in the HPS N13.30 Standard and proposed in ISO documents for standardization were used for activity measurements. During the period January 2010 to December 2014, approximately 4500 measurements had been carried in workers who develop tasks related to the production and research. The activities of the radionuclides and the workers' tasks relationship had been evaluated. (author)

  4. Genotoxic effects of textile printing dye exposed workers in India detected by micronucleus assay.

    Science.gov (United States)

    Sellappa, Sudha; Prathyumnan, Shibily; Joseph, Shyn; Keyan, Kripa S; Balachandar, Vellingiri

    2010-01-01

    The textile printing industry in South India employs a great number of workers that may possibly be exposed to toxic compounds. In the present study, subjects from textile printing units were investigated for the presence of genetic damage in their peripheral blood lymphocytes using micronucleus assay. Proliferation was also investigated using a nuclear division index. It was found that the micronucleus frequency was considerably greater in exposed subjects than in non exposed control subjects, but division was not increased in a statistically significant way. For the time being, this investigation should be considered as a preliminary study in which the influence of potential confounders could be adequately assessed. However, our results are non-ambiguous, indicating a potential health risk in these workers.

  5. [Detection of sister chromatic exchange in workers exposed to coal tar pitch and to coke oven volatiles].

    Science.gov (United States)

    Wang, X; Chen, C; Wu, Y; Xu, Y

    1998-07-01

    In order to know the changes of genetic toxicological effects on workers occupationally exposed to polycyclic aromatic hydrocarbons (PAHs), sister chromatic exchange(SCE) was detected by the methods of peripheral lymphocyte culture in 23 workers exposed to coal tar pitch (CTP) and in 19 workers exposed to coke oven volatiles (COV) and 12 normal controls. The results suggested that the SCE in occupational workers was significantly higher than that in controls (11.31 vs 6.37, P 0.05). It is indicated that CTP and COV caused strong genetic toxicity and injury to chromosome.

  6. Mortality and causes of death among workers exposed to phosgene in 1943-45

    International Nuclear Information System (INIS)

    Mortality and causes of death from death certificates were analyzed among workers exposed to phosgene while working at a uranium-processing plant in Tennessee in 1943-45. Standardized mortality ratios (SMRs) were calculated by using death rates for U.S. white males. As of 1979, SMRs for all causes and for various selected causes were similar in 694 male chemical workers chronically exposed to low levels of phosgene in 1943-45 and in 9280 male controls who worked at the same plant. SMRs for diseases of the respiratory system were 107 (14 observed vs. 13.07 expected) in the chemical workers and 119 (292 observed vs. 245.75 expected) in the controls. In a group of 106 males who were acutely exposed to high levels of phosgene, there were 41 deaths observed vs. 33.87 expected (SMR = 121; 95% confidence limits = 86 and 165). One death, occurring within 24 hours of exposure, was from pulmonary edema due to phosgene poisoning (coded to accidental causes). Five deaths were coded to diseases of the respiratory system (SMR = 266; 95% CL = 86 and 622); in 2 of these 5 deaths, bronchitis due to phosgene exposure had been reported in 1945. Among 91 female workers with acute high-level phosgene exposure, frequencies of symptoms and early health effects (pneumonitis and bronchitis) differed from those reported for the 106 male cases; preliminary data on vital status of these females are too incomplete for analysis, and further follow-up is needed

  7. Measurement of vitamin D3 metabolites in smelter workers exposed to lead and cadmium

    OpenAIRE

    Chalkley, S. R.; Richmond, J; Barltrop, D.

    1998-01-01

    OBJECTIVES: To investigate the effects of lead and cadmium on the metabolic pathway of vitamin D3. METHODS: Blood and urinary cadmium and urinary total proteins were measured in 59 smelter workers occupationally exposed to lead and cadmium. In 19 of these workers, the plasma vitamin D3 metabolites, (25-hydroxycholecalciferol (25 OHD3), 24R, 25-dihydroxycholecalciferol (24R,25(OH)2D3) and 1 alpha,25- dihydroxycholecalciferol (1 alpha, 25(OH)2D3)) were measured together with blood lead. V...

  8. Occupational allergic and irritant contact dermatitis in workers exposed to polyurethane foam

    Directory of Open Access Journals (Sweden)

    Marta Kieć-Świerczyńska

    2014-04-01

    Full Text Available Objectives: To evaluate sensitization to chemicals present in work environment after an outbreak of contact dermatitis in workers of vehicle equipment factory, exposed to polyurethane foam, based on 4,4'-diphenylmethane diisocyanate (MDI. Material and Methods: From among 300 employees, 21 individuals reporting work-related skin and/or respiratory tract symptoms underwent clinical examination, patch testing, skin prick tests, spirometry and MDI sIgE measurement in serum. Patch tests included isocyanates series, selected rubber additives, metals, fragrances, preservatives, and an antiadhesive agent. Results: Clinical examination revealed current eczema in the area of hands and/or forearms in 10 workers. Positive patch test reactions were found in 10 individuals, the most frequent to diaminodiphenylmethane and 4-phenylenediamine (7 persons. Reactions to an antiadhesive agent were assessed as irritant (5 workers. Except for sensitization to common aeroallergens, no significant abnormalities were found in the remaining tests. Occupational allergic contact dermatitis was diagnosed in 7 workers, irritant contact dermatitis in 10 and coexisiting allergic and irritant contact dermatitis in 3 workers. Conclusions: In workers manufacturing products from polyurethane foam, attention should be paid to the risk of developing contact dermatitis. Skin problems in our study group were attributable probably to insufficient protection of the skin.

  9. Paraoxonase-1 genetic polymorphisms and susceptibility to DNA damage in workers occupationally exposed to organophosphate pesticides.

    Science.gov (United States)

    Singh, Satyender; Kumar, Vivek; Thakur, Sachin; Banerjee, Basu Dev; Rautela, Rajender Singh; Grover, Shyam Sunder; Rawat, Devendra Singh; Pasha, Syed Tazeen; Jain, Sudhir Kumar; Ichhpujani, Rattan Lal; Rai, Arvind

    2011-04-15

    Human paraoxonase 1 (PON1) is a lipoprotein-associated enzyme involved in the detoxification of organophosphate pesticides (OPs) by hydrolyzing the bioactive oxons. Polymorphisms of the PON1 gene are responsible for variation in the expression and catalytic activity of PON1 enzyme. In the present study, we have determined (a) the prevalence of two common PON1 polymorphisms, (b) the activity of PON1 and acetylcholinesterase enzymes, and (c) the influence of PON1 genotypes and phenotypes variation on DNA damage in workers exposed to OPs. We examined 230 subjects including 115 workers exposed to OPs and an equal number of normal healthy controls. The results revealed that PON1 activity toward paraoxon (179.19±39.36 vs. 241.52±42.32nmol/min/ml in controls) and phenylacetate (112.74±17.37 vs. 134.28±25.49μmol/min/ml in controls) was significantly lower in workers than in control subjects (p0.05). The PON1 activity toward paraoxonase was found to be significantly higher in the R/R (Arg/Arg) genotypes than Q/R (Gln/Arg) and lowest in Q/Q (Gln/Gln) genotypes in both workers and control subjects (p<0.001). For PON1(55)LM (Leu/Met), PON1 activity toward paraoxonase was observed to be higher in individuals with L/L (Leu/Leu) genotypes and lowest in individuals with M/M (Met/Met) genotypes in both groups (p<0.001). No influence of PON1 genotypes and phenotypes was seen on the activity of acetylcholinesterase and arylesterase. The DNA damage was observed to be significantly higher in workers than in control subjects (p<0.05). Further, the individuals who showed least paraoxonase activity i.e., those with (Q/Q [Gln/Gln] and M/M [Met/Met]) genotypes showed significantly higher DNA damage compared to other isoforms in workers exposed to OPs (p<0.05). The results indicate that the individuals with PON1 Q/Q and M/M genotypes are more susceptible toward genotoxicity. In conclusion, the study suggests wide variation in enzyme activities and DNA damage due to polymorphisms in PON1

  10. Compensation for damage to workers health exposed to ionizing radiation in Argentina

    CERN Document Server

    Sobehart, L J

    2003-01-01

    The objective of this report is to analyze the possibility to establish a scheme to compensate damage to workers health exposed to ionizing radiation in Argentina for those cases in which it is possible to assume that the exposure to ionizing radiation is the cause of the cancer suffered by the worker. The proposed scheme is based on the recommendations set out in the 'International Conference on Occupational Radiation Protection: Protecting Workers against Exposure to Ionization Radiation, held in Geneva, Switzerland, August 26-30, 2002. To this end, the study analyzes the present state of scientific knowledge on cancer causation due to genotoxic factors, and the accepted form of the doses-response curve, for the human beings exposure to ionization radiation at low doses with low doses rates. Finally, the labor laws and regulations related to damage compensation; in particular the present Argentine Labor Law; the National Russian Federal Occupational Radiological Health Impairment and Workmen Compensation, t...

  11. A retrospective mortality study of workers exposed to radon in a Brazilian coal mine

    International Nuclear Information System (INIS)

    High levels of radon concentration were found in the underground workplace of an underground coal mine in Parana state, which has been in activity since 1942. Many of these workers were exposed for a long period of time to a work atmosphere with high radon, and radon decay products concentration. Taking this into account, it was decided to carry on a historical cohort, study with the workers' of this mining universe (underground and surface) in. order to evaluate the possible health effects related to this exposure, by means of a retrospective study of mortality. Through multiple strategies, it was possible to trace the vital status of 90% of the cohort. The causes of the deaths were identified by active search, of Death Declarations in the Health Office of Parana state and also in and other states. The success rate of cause of death identification was 100%. The final, cohort included 1946 underground workers and 910 surface workers. Standard mortality ratio (SMR) analysis showed lower mortality from all causes for both underground (SMR-88, 95%CI=78-98) and surface workers (SMR=96, 95%CI=81- 113). A highly significant SMR was observed for pneumonia cause of death among surface ((SMR=284, 95%CI=118-684) and underground miners (SMR-254, 95%CI=140-459), while a highly significant lung cancer mortality risk was observed only for underground miners (SMR=177, 95%CI=105-299) with a significant trend in relation to years of underground work (duration of exposure). Taking into account that mortality from smoking-related cancers other than lung cancer is not elevated in underground workers and diesel equipment were not used at this mine, the results suggest that the exposure to radon daughters may have been responsible for the lung cancer excess among underground workers. This work consists of the first historical Brazilian cohort involving miners exposed to radon and one of the few historical cohorts built in Brazil. It should be considered the fact that many workers of

  12. Serum activities of liver enzymes in workers exposed to sub-TLV levels of dimethylformamide

    Directory of Open Access Journals (Sweden)

    Jinjiang He

    2015-04-01

    Full Text Available Objectives: The aim of this study has been to investigate serum activities of liver enzymes in workers exposed to sub-TLV levels of dimethylformamide (DMF. Material and Methods: Seventy-two workers and 72 healthy controls participated in the study. All subjects underwent complete physical examinations and abdominal ultrasound examination. Serum aspartate aminotransferase (AST, alanine aminotransferase (ALT, and c-glutamyl transpeptidase (c-GT were determined by an auto-chemistry analyzer. The data of airborne concentrations of DMF was obtained from the local Center of Disease Control and Prevention. The level of urine N-acetyl-S-(N-methylcarbamoylcysteine (AMCC was measured by means of high-performance liquid chromatography. Results: Time weighted average (TWA concentration of the DMF in workplace was 18.6 (range: 9.8–36.2 mg/m3. The concentration of the AMCC in workers’ urine was 28.32 (range: 1.8–58.6 mg/l and 9 workers’ AMCC exceeded the biological exposure index (40 mg/l. Thirty-one workers reported gastrointestinal symptoms (abdominal pain, nausea, anorexia and 10 workers reported headache, dizziness and/or palpitation in the exposed group. Serum analysis revealed that both the mean of serum activities of liver enzymes (ALT, AST and c-GT and the percentage of workers with abnormal liver function were significantly higher in the exposed group as compared to the controls. Conclusions: Dimethylformamide can cause liver damage even if air concentration is in the sub-threshold limit value (sub-TLV level. The protection of skin contact against the exposure to the DMF might be a critical issue as far as the occupational health is concerned.

  13. Thalamic GABA predicts fine motor performance in manganese-exposed smelter workers.

    Directory of Open Access Journals (Sweden)

    Zaiyang Long

    Full Text Available Overexposure to manganese (Mn may lead to parkinsonian symptoms including motor deficits. The main inhibitory neurotransmitter gamma-aminobutyric acid (GABA is known to play a pivotal role in the regulation and performance of movement. Therefore this study was aimed at testing the hypothesis that an alteration of GABA following Mn exposure may be associated with fine motor performance in occupationally exposed workers and may underlie the mechanism of Mn-induced motor deficits. A cohort of nine Mn-exposed male smelter workers from an Mn-iron alloy factory and 23 gender- and age-matched controls were recruited and underwent neurological exams, magnetic resonance spectroscopy (MRS measurements, and Purdue pegboard motor testing. Short-echo-time MRS was used to measure N-Acetyl-aspartate (NAA and myo-inositol (mI. GABA was detected with a MEGA-PRESS J-editing MRS sequence. The mean thalamic GABA level was significantly increased in smelter workers compared to controls (p = 0.009. Multiple linear regression analysis reveals (1 a significant association between the increase in GABA level and the duration of exposure (R(2 = 0.660, p = 0.039, and (2 significant inverse associations between GABA levels and all Purdue pegboard test scores (for summation of all scores R(2 = 0.902, p = 0.001 in the smelter workers. In addition, levels of mI were reduced significantly in the thalamus and PCC of smelter workers compared to controls (p = 0.030 and p = 0.009, respectively. In conclusion, our results show clear associations between thalamic GABA levels and fine motor performance. Thus in Mn-exposed subjects, increased thalamic GABA levels may serve as a biomarker for subtle deficits in motor control and may become valuable for early diagnosis of Mn poisoning.

  14. Cancer risks in workers exposed to radiofrequency and microwave radiation: an epidemiologic study

    International Nuclear Information System (INIS)

    Radiofrequency (RF) and microwave (MW) radiations can penetrate human tissue as and exert various bioeffects at relatively low field power densities. In workers exposed occupationally to RF/MW, radiation development of various functional abnormalities of neural, immune, or cardiovascular systems is also possible. Experimental investigations revealed the possibility of epigenetic activity of certain MW exposures, but there exist single epidemiological studies which indicate increased mortality of neoplasms in workers exposed to microwave radiation. As an example, the multi year study of cancer morbidity in Polish military personnel are presented. Despite of the reported increased morbidity of haematopoietic and lymphatic neoplasms, it was not possible to confirm the causal link of the morbidity with exposure to MW radiation

  15. [Precancerous conditions of the larynx in workers exposed to dust and their prevention].

    Science.gov (United States)

    Podol'skaia, E V

    1989-01-01

    This paper presents the results of examinations of 522 workers exposed to various industrial dusts and 361 workers exposed to different concentrations of carcinogenic asbestos dust. The examinations showed a significantly higher incidence of total processes in the upper respiratory tract which manifested as chronic subatrophic nasopharingitis and hyperplastic laryngitis. Also, they demonstrated a significantly higher incidence of local processes that manifested as hyperplasia of the laryngeal mucosa and contact fibromas. These laryngeal lesions can be viewed as etiologically associated with the effect of industrial dusts having traumatic (abrasive and glass dust) and carcinogenic (asbestos) properties. Patients with the above laryngeal pathologies should be removed from the dust environment and sent to physical examinations with emphasis on occupational diseases.

  16. Silicosis in Workers Exposed to Artificial Quartz Conglomerates: Does It Differ From Chronic Simple Silicosis?

    Science.gov (United States)

    Paolucci, Valentina; Romeo, Riccardo; Sisinni, Antonietta Gerardina; Bartoli, Dusca; Mazzei, Maria Antonietta; Sartorelli, Pietro

    2015-12-01

    Recently, a number of reports have been published on silicosis in workers exposed to artificial quartz conglomerates containing high levels of crystalline silica particles (70-90%) used in the construction of kitchen and bathroom surfaces. Three cases of silicosis in workers exposed to artificial quartz conglomerates are reported. The diagnosis was derived from both the International Labour Office and the International Classification of HRCT for Occupational and Environmental Respiratory Diseases (ICOERD) classifications and cytological analysis of bronchoalveolar lavage fluid. In 2 cases, levels of respirable silica greatly in excess of recommended standards were measured in the workplace, and cytological analysis of bronchoalveolar lavage fluid highlighted a prevalence of lymphocytes, meeting criteria for the diagnosis of accelerated silicosis. The prevention of pneumoconiosis caused by the use of innovative materials, such as artificial conglomerates with high crystalline silica content must be addressed. PMID:26410340

  17. Hearing Impairment Among Noise-Exposed Workers - United States, 2003-2012.

    Science.gov (United States)

    Masterson, Elizabeth A; Bushnell, P Timothy; Themann, Christa L; Morata, Thais C

    2016-01-01

    Hearing loss is the third most common chronic physical condition in the United States, and is more prevalent than diabetes or cancer (1). Occupational hearing loss, primarily caused by high noise exposure, is the most common U.S. work-related illness (2). Approximately 22 million U.S. workers are exposed to hazardous occupational noise (3). CDC compared the prevalence of hearing impairment within nine U.S. industry sectors using 1,413,789 noise-exposed worker audiograms from CDC's National Institute for Occupational Safety and Health (NIOSH) Occupational Hearing Loss Surveillance Project (4). CDC estimated the prevalence at six hearing impairment levels, measured in the better ear, and the impact on quality of life expressed as annual disability-adjusted life years (DALYs), as defined by the 2013 Global Burden of Disease (GBD) Study (5). The mining sector had the highest prevalence of workers with any hearing impairment, and with moderate or worse impairment, followed by the construction and manufacturing sectors. Hearing loss prevention, and early detection and intervention to avoid additional hearing loss, are critical to preserve worker quality of life. PMID:27101435

  18. Hemoglobinopatias em trabalhadores expostos à riscos ocupacionais Hemoglobinopathies in workers exposed to occupational hazards

    Directory of Open Access Journals (Sweden)

    Isaac L. Silva Filho

    2002-12-01

    Full Text Available Hemoglobinopathies have been considered the most frequent hereditary disease in Brazilian population, constituting a Public Health problem. This paper reports on screening in workers at FIOCRUZ-RJ., exposed to some hazards factors such as, chemical substances, radiation, excessive cold and heat etc., with the objective of evaluating the impact of these factors in carriers of hemoglobinopathies, mainly in sickle cell trait (AS.

  19. PON1 Status Does Not Influence Cholinesterase Activity in Egyptian Agricultural Workers Exposed to Chlorpyrifos

    OpenAIRE

    Ellison, Corie A.; Crane, Alice L.; Bonner, Matthew R; Knaak, James B.; Browne, Richard W; Lein, Pamela J; Olson, James R.

    2012-01-01

    Animal studies have shown that paraoxonase 1 (PON1) genotype can influence susceptibility to the organophosphorus pesticide chlorpyrifos (CPF). However, Monte Carlo analysis suggests that PON1 genotype may not affect CPF-related toxicity at low exposure conditions in humans. The current study sought to determine the influence of PON1 genotype on the activity of blood cholinesterase as well as the effect of CPF exposure on serum PON1 in workers occupationally exposed to CPF. Saliva, blood and ...

  20. Biological monitoring of workers exposed to benzene in the coke oven industry.

    OpenAIRE

    Drummond, L; Luck, R; Afacan, A. S.; Wilson, H K

    1988-01-01

    Workers in the coke oven industry are potentially exposed to low concentrations of benzene. There is a need to establish a well validated biological monitoring procedure for low level benzene exposure. The use of breath and blood benzene and urinary phenol has been explored in conjunction with personal monitoring data. At exposures of about 1 ppm benzene, urinary phenol is of no value as an indicator of uptake/exposure. Benzene in blood was measured by head space gas chromatography but the co...

  1. Albumin Adducts of Electrophilic Benzene Metabolites in Benzene-Exposed and Control Workers

    OpenAIRE

    Lin, Yu-Sheng; Vermeulen, Roel; Tsai, Chin H.; Waidyanatha, Suramya; Lan, Qing; Rothman, Nathaniel; Smith, Martyn T.; Zhang, Luoping; Shen, Min; Li, Guilan; Yin, Songnian; Kim, Sungkyoon; Rappaport, Stephen M.

    2006-01-01

    Background Metabolism of benzene produces reactive electrophiles, including benzene oxide (BO), 1,4-benzoquinone (1,4-BQ), and 1,2-benzoquinone (1,2-BQ), that are capable of reacting with blood proteins to produce adducts. Objectives The main purpose of this study was to characterize relationships between levels of albumin adducts of these electrophiles in blood and the corresponding benzene exposures in benzene-exposed and control workers, after adjusting for important covariates. Because se...

  2. Incidence of cancer and mortality among workers exposed to mercury vapour in the Norwegian chloralkali industry.

    OpenAIRE

    Ellingsen, D G; Andersen, A; Nordhagen, H P; Efskind, J; Kjuus, H

    1993-01-01

    Incidence of cancer and mortality were studied among 674 men exposed to mercury vapour for more than one year at two chloralkali plants. Mercury excretion in urine had been monitored among the workers at the two plants since 1948 and 1949. An individual cumulative urinary mercury dose was calculated, based on about 20,000 urinary mercury measurements. The incidence of cancer and the mortality were followed up from 1953 to 1989 and 1953 to 1988 respectively. The general Norwegian male populati...

  3. Scientific colloquium on medical supervision of workers exposed to ionizing and non ionizing radiations

    International Nuclear Information System (INIS)

    The general principles of medical surveillance for workers exposed to ionizing radiation were defined in the Euratom Basic Standards in 1959. These principles, which are in accordance with the early IGRP publications, have been adopted by the national authorities and implemented without difficulty. However, because of the forthcoming publication of the revised Basic Standards- in accordance with recent IGRP recommendations, the Commission decided to organize a meeting of doctors responsible for the medical surveillance of workers exposed to ionizing radiation in order to disseminate as widely as possible the results of experience gained in the field of radiological protection and to pinpoint the practical difficulties which might arise when the principles were applied. The Commission also considered it important to inform doctors specializing in radiological protection about the principles to be followed by those responsible for the health protection of workers exposed to non-ionizing radiation, particularly microwaves and Laser beams. The complete text of each report in the original language is given in this volume

  4. Determination of bromine contents in blood and hair of workers exposed to methyl by radioactivation analysis method bromide

    International Nuclear Information System (INIS)

    The bromine contained in blood and hair samples obtained from workers exposed to methyl bromide was analyzed by nondestructive activation analysis. The samples were irradiated for 1 min in pneumatic irradiation facility of Kyoto University research reactor with an estimated thermal neutron flux density at 2 x 1013 n.cm-2.sec-1. The irradiation was counted with Ge(Li) detector. The duration of measurement of radionuclide bromine in blood and hair was 200 sec within 2 - 10 min after irradiation. The bromine content of serum sample obtained from a worker suspected of methyl bromide poisoning was found to be 412 μg/g on 13 days apart from exposure to methyl bromide. The biological half-life of bromine in this case was found to be about 16 days. Then bromine contents in serum and hair samples obtained from workers exposed to methyl bromide were found to be 1.7 and 2.6 times higher respectively than those of nonexposed workers. Any correlations of bromine contents were not observed between serum and hair samples obtained from workers exposed to methyl bromide, nor between bromine amount in the serum of workers exposed to methyl bromide and the terms exposed to it, but statistically significant positive correlation was observed between bromine amount in the hair of workers exposed to methyl bromide and the terms exposed to it. (author)

  5. Preliminary results from a cohort of workers exposed to wollastonite in a Finish limestone quarry.

    Science.gov (United States)

    Huuskonen, M S; Järvisalo, J; Koskinen, H; Nickels, J; Räsänen, J; Asp, S

    1983-04-01

    Wollastonite metasilicate fibers are rather similar in form, length, and diameter, but mineralogically different, to amphibole asbestos fibers. We have studied immunologic findings from 46 men exposed to wollastonite at a limestone quarry for at least 10 years. These workers showed a higher prevalence of positive serum rheumatoid factors than blood donors did. This finding resembles the one detected among asbestos workers. The group of wollastonite workers with radiological signs of pulmonary fibrosis had activities of serum angiotensin-converting enzyme that were similar to those of wollastonite workers without fibrosis. A mortality study of 238 quarry workers with 5,769 person-years was, as expected, nonpositive. It was interesting that one woman with 20 years of exposure to wollastonite and with no other known exposure to fibers revealed a malignant retroperitoneal mesenchymal tumor 30 years after the initial exposure. This kind of very rare tumor is difficult to distinguish from mesothelioma. However, this is only one case, and it is impossible to draw any definite conclusions.

  6. Assessment of biomarkers in asbestos-exposed workers as indicators of cancer risk.

    Science.gov (United States)

    Amati, Monica; Tomasetti, Marco; Mariotti, Laura; Tarquini, Lucia Miria; Valentino, Matteo; Santarelli, Lory

    2008-01-01

    Epidemiological studies have shown that mortality from malignant mesothelioma (MM) and lung cancer have increased with increasing cumulative exposure to asbestos. To investigate whether tumour-related biomarkers can contribute towards the evaluation of the carcinogenic risk in populations exposed to asbestos, the DNA adduct 8-hydroxy-2'-deoxyguanosine (80HdG), interleukine-6 (IL-6), platelet-derived growth factor (PDGF-BB), hepatocyte growth factor (HGF), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGFbeta) and soluble mesothelin-related peptides (SMRPs) were analysed in a cohort of workers differently exposed to asbestos fibres at the workplace. To document biomarker levels in an unexposed population, 54 age-matched subjects were enrolled. A total of 119 subjects with a history of occupational exposure to asbestos underwent clinical examination and were interviewed by trained personnel, responding to a detailed questionnaire related to duration of asbestos exposure, smoking, and occupational task. According to the occupational tasks, asbestos-exposed subjects were analysed for their asbestos cumulative dose and the association with the biomarkers was evaluated. Among the occupational groups, maintenance workers, pipe fitters and electricians were exposed to a higher cumulative dose of asbestos fibres. Exposure to asbestos significantly increased the steady-state content of 80HdG in DNA. Elevated levels of 80HdG and IL-6 best reflected a high level of SMRPs, which is related to cell transformation. Subjects heavily exposed to asbestos [> 60(ff/cm3) x years] showed also a higher level of angiogenic factors. A combination of angiogenic biomarkers with a specific mesothelioma-biomarker such as SMRPs could be used for close surveillance of workers with a history of asbestos exposure. PMID:18638565

  7. Cytogenetic and hematological studies in the workers occupationally exposed to low levels of ionizing radiation

    International Nuclear Information System (INIS)

    Complete text of publication follows. Objective: This study was aimed at detecting both the incidence of chromosomal aberrations and changes in the hematological parameters as biomarkers of possible radiation injury among workers occupationally exposed to low levels of ionizing radiation and detecting the dose-effect relationship. Methods: Samples of peripheral blood were collected from 38 male industrial radiographers exposed to ionizing radiation for 1-16 years and from 24 age- and sex-matched healthy blood donors without radiation history served as control group. All radiation workers were routinely monitored with film badge. Cytogenetic analysis in peripheral blood lymphocytes assessed by the conventional chromosome aberration assay and at least 200 metaphases for each person were scored. The collected blood samples were analyzed for hematological assay using an automatic analyzer Sysmex KX-21, where 14 different parameters were computerized. Mann-Whitney U test was used to compare the frequencies of the unstable aberrations and hematological parameters between test and control groups. Dose-effect relationship and the influence of age and duration of employment was tested by regression analysis. Results and conclusion: The mean frequencies of dicentric and acentric chromosome aberrations were significantly higher in the exposed group than in the control group (P< 0.0005). No correlation between chromosomal aberrations and physical dose and age was observed in the exposed group. Also there is no clear relation between chromosome damage and duration of exposure. However, the increase in chromosome aberrations in the exposed group was not followed by a corresponding hematological depression. The average values of hematological indices were within the reference levels and did not show any significant differences with control group. A tendency of decreasing the absolute lymphocyte count within the referential levels was the only hematological effect in radiation

  8. Diagnostic tests in Raynaud's phenomena in workers exposed to vibration: a comparative study

    DEFF Research Database (Denmark)

    Olsen, N

    1988-01-01

    greater than 0.20). The results indicate that a finger colour test may be as valuable as a FSP(0) test for diagnostic purposes. FSP(A) only indicates if a cold response is exaggerated and does not diagnose RP. The pressure measurements may further be of guidance in evaluating preventive measures......Four objective tests to evaluate Raynaud's phenomena (RP) in workers exposed to handarm vibrations were applied on 23 exposed men with RP (vibration induced white finger 18, primary Raynaud's phenomenon 5), 56 exposed men without RP, and 15 male controls. Finger systolic blood pressure was measured...... by a cuff and strain gauge technique after combined body cooling and finger cooling during five minute ischaemia to 30 degrees, 15 degrees, and 6 degrees C. An attack of RP was detected as a zero pressure, FSP(0) test, whereas a pressure, reduced to a value below the normal 95% confidence limit at 6 degrees...

  9. Sero-prevalence of brucellosis in occupationally exposed human beings of Himachal Pradesh (India).

    Science.gov (United States)

    Shalmali; Panda, Ashok Kumar; Chahota, Rajesh

    2012-06-01

    The chief objective of respective study was to investigate the seroprevalence of brucellosis among occupationally exposed human beings in Himachal Pradesh. A total of 165 serum samples that were obtained from human beings from various regions of the state were screened through a battery of serological tests which included RBPT, STAT, 2-MET, dot-ELISA and indirect-ELISA. 165 of human sera samples included 42 from veterinarians, 40 shepherds, 35 livestock owners, 20 workers at veterinary hospitals/clinics, 16 abattoir workers and 12 veterinary pharmacists. The overall seroprevalence of brucellosis among occupationally exposed human beings was observed to be 6.66% showing highest in abattoir workers (18.75%) followed by pharmacists (8.33%), veterinarians (7.14%), and livestock owners (5.71%) and shepherds (5.00%). In humans it is prevalent as an occult infection or under diagnosed disease, especially; in case of abattoir workers the highest seropositivity for brucella agglutinins was observed. Indirect-ELISA and Dot-ELISA proved best in the diagnosis of brucellosis.

  10. [Studies on the Ras p21 levels in workers exposed to coal tar pitch and coke oven volatiles].

    Science.gov (United States)

    Wang, X; Wu, Y; Chen, C

    1998-09-30

    To study the effects of serum p21 levels on the health of coal tar pitch(CTP) and coke oven volatiles (COV) workers recognized as the high risk population of pulmonary carcinoma, serum p21 levels among 24 cases of CTP workers, 25 cases of COV workers and 12 cases of normal control were detected with the method of Western Blotting. The results showed that the mean serum p21 level in exposed group was significantly higher than that in the normal control (366.8 vs 1270.7, P < 0.001). In the COV workers, serum p21 level in coke furnace workers was remarkably higher than that in the workers with other types of work. There were no differences for p21 among workers with different work years and between workers with or without smoking history. It indicates that CTP and COV can cause the p21 protein level increase in the occupational population.

  11. 44. Study the level of DNA breakage in workers exposed to styrene by single cell gel electrophoresis

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective: Study the level of DNA breakage in workers exposed to styrene. Methods: 35 workers aging from 18 to 40 exposed to styrene half a year above were observed as exposed group, in the mean time, 57 workers in the same district who hadn't been exposed to known genotoxicant were selected as control. Bloods of them were sampled and DNA lesions were detected by single cell gel electrophoresis. Results: Compared with control, the ratio between the length of Comet tail and the total length of Comet in exposed group significantly increased, especially it raised following the styrene concentration exposed, but it was not different among different working age groups. Conclusions: DNA is damaged by styrene, and it appears as dose-response relationship.

  12. Biomonitoring for chromium and arsenic in timber treatment plant workers exposed to CCA wood Preservatives.

    Science.gov (United States)

    Cocker, J; Morton, J; Warren, N; Wheeler, J P; Garrod, A N I

    2006-07-01

    This study reports a survey of occupational exposure to copper chrome arsenic (CCA) based wood preservatives during vacuum pressure timber impregnation. The survey involved biological monitoring based on analysis of chromium and arsenic in urine samples collected from UK workers. The aim of the study was to determine the extent of occupational exposure to arsenic and chromium in the UK timber treatment industry. The objectives were to collect and analyse urine samples from as many workers as possible, where CCA wood preservatives might be used, at 6 monthly intervals for 2 years. In addition, to investigate day-to-day variations in urinary excretion of chrome and arsenic by collecting and analysing three samples a week for 3 weeks in subsets of workers and controls (people not occupationally exposed). All urine samples were analysed for chromium and inorganic arsenic. To investigate any residual interference every sample was accompanied by a short questionnaire about recent consumption of seafood and smoking. The analytical methods for arsenic used a hydride generation technique to reduce interference from dietary sources of arsenic and also a technique that would measure total arsenic concentration in urine. The main findings show that workers exposed to CCA wood preservatives have concentrations of inorganic arsenic and chromium in urine that are significantly higher than those from non-occupationally exposed people but below biological monitoring guidance values that would indicate inhalation exposure at UK occupational exposure limits for chromium and arsenic. The effects of consumption of seafood on urinary arsenic were not significant using the hydride generation method for inorganic arsenic but were significant if 'total' arsenic was measured. The 'total' arsenic method could not distinguish CCA workers from controls and is clearly unsuitable for assessment of occupational exposure to arsenic. There was a significant increase in the urinary concentration of

  13. Clinical, cytogenetic and toxicological studies in rural workers exposed to pesticides in Botucatu, São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Salete Marcia Bréga

    1998-01-01

    Full Text Available Pesticides can cause gene mutations and chromosomal aberrations in exposed individuals. We have investigated 24 workers exposed to pesticides. Clinical examinations and cytogenetic and toxicological tests were performed. Ten non-exposed individuals were used as controls. Toxicological dosages of copper, zinc and manganese (metals found in some pesticides, hepatic enzyme dosage (GOT, GPT, AR and acetylcholinesterase activity were performed in 16 workers and 8 controls. In the exposed workers, the most relevant clinical symptoms were poor digestion with fullness sensation after meals, irritated eyes, headache and fasciculations. The exposed group showed significantly lower manganese dosage and acetylcholinesterase activity, and significantly higher levels of alkaline phosphatase. Cytogenetic studies showed significantly higher chromosomal aberrations in the exposed group compared to the control group. Although the workers used protection against the pesticide's fog, the results revealed that the workers were contaminated with the pesticides. Therefore, the cytogenetic, toxicological studies with clinical examination are necessary for monitoring workers who are exposed to pesticides in any situation.

  14. The noise exposed factory workers: the prevalence of sensori-neural hearing loss and their use of personal hearing protection devices.

    Science.gov (United States)

    Maisarah, S Z; Said, H

    1993-09-01

    A total of 524 industrial workers were studied. They consisted of 442 noise exposed and 82 non-noise exposed workers. The purpose was to compare the prevalence of sensori-neural hearing loss among the noise exposed and the non-noise exposed workers, to study their knowledge on the hazard of noise to hearing and the workers' attitude towards the hearing protection devices. The prevalence of sensori-neural hearing loss was significantly higher among the noise exposed workers, i.e., 83% versus 31.7% (p workers, only 5.1% were wearing them regularly. The possibility of developing hearing loss due to exposure to excessive noise was only known by 35.5% of the noise exposed workers. This awareness was found to have a positive correlation with the workers' compliance to the hearing protection devices. Our findings highlight the need for workers to be educated on the hazards of excessive noise exposure to hearing.

  15. Investigation on injury of liver and kindey among the workers exposed to terephthalic acid, ethylene glycol and (or) dowtherm A.

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Objective: To study injury of liver and kidney among the workers exposed to terephthalic acid (TPA), ethylene glycol(EG) and (or) dowtherm A(DOW), and to research for the early biological monitoring indexes.

  16. A cytogenetic approach to the effects of low levels of ionizing radiation (IR) on the exposed Tunisian hospital workers

    OpenAIRE

    Sana Bouraoui; Soumaya Mougou; Afef Drira; Faten Tabka; Nouha Bouali; Najib Mrizek; Hatem Elghezal; Ali Saad

    2013-01-01

    Objectives: The aim of this study is to assess chromosomal damage in Tunisian hospital workers occupationally exposed to low levels of ionizing radiation (IR). Materials and Methods: The cytokinesis-block micronucleus (CBMN) assay in the peripheral lymphocytes of 67 exposed workers compared to 43 controls matched for gender, age and smoking habits was used. The clastogenic/aneugenic effect of IR was evaluated using the CBMN assay in combination with fluorescence in situ hybridization with hum...

  17. Decreased levels of CXC-chemokines in serum of benzene-exposed workers identified by array-based proteomics

    OpenAIRE

    Vermeulen, Roel; Lan, Qing; Zhang, Luoping; Gunn, Laura; McCarthy, Diane; Woodbury, Ronald L; McGuire, Marielena; Podust, Vladimir N.; Li, Guilan; Chatterjee, Nilanjan; Mu, Ruidong; Yin, Songnian; Rothman, Nathaniel; Smith, Martyn T.

    2005-01-01

    Benzene is an important industrial chemical and environmental contaminant that causes leukemia. To obtain mechanistic insight into benzene's mechanism of action, we examined the impact of benzene on the human serum proteome in a study of exposed healthy shoe-factory workers and unexposed controls. Two sequential studies were performed, each using sera from 10 workers exposed to benzene (overall mean benzene air level >30 ppm) and 10 controls. Serum samples were subjected to anion-exchange fra...

  18. [Liver function of workers occupationally exposed to mixed organic solvents in a petrochemical industry].

    Science.gov (United States)

    Fernández-D'Pool, J; Oroño-Osorio, A

    2001-06-01

    A descriptive and cross sectional study was conducted to determine whether hepatic function changes in workers occupationally exposed to a mixture of organic solvents, were due to the exposure or confusing factors. A non random sample of 77 workers, operators and supervisors of the Olefin Plant I and II of a petrochemical industry in Maracaibo, Venezuela, was used. Their mean age was 29 +/- 7 years, and had at least one year of exposure to the solvents. This sample was compared with a group of employees of the administrative offices or control panel workers, with a mean age of 36 +/- 8 year and with similar anthropometric characteristics. Workers with a known history of liver disease, blood transfusions and diabetes mellitus were excluded of the study. In addition to a complete occupational disease medical history and a physical examination, serum samples were obtained to determine the activity of the aspartato aminotransferase (AST), alanin aminotransferase (ALT), gamma glutamiltransferase (GGT), alkaline phosphatase (AF), the concentration of the total bile acids (BAS), the surface antigen of hepatitis B(HbsAg) and the hepatitis A virus antibodies: AntiHAV-IgG and the AntiHAV-IgM. An urine sample was taken and analyzed by standard methodology to determine urinary phenols. The air concentrations of benzene, ethylbenzene, toluene and xylene were analyzed by gas chromathography. The serum activities of the liver enzymes, the concentration of bile acids and urinary phenols were not influenced by the exposure to the solvents. The increase of the activity of GGT was associated with obesity and alcohol consumption. The antibodies of the surface antigen of hepatitis A-IgM were normal in both groups and the antibodies for the antigen of hepatitis A-IgG presented a prevalence of 6% in the exposed group and 9% in the non exposed not being associated with liver abnormalities. The individual air concentrations of the solvents were below the environmentally permissible

  19. Double Jeopardy: Hearing Loss and Tinnitus Among Noise-Exposed Workers.

    Science.gov (United States)

    Hong, OiSaeng; Chin, Dal Lae; Phelps, Stephanie; Joo, Yoonmee

    2016-06-01

    The purpose of this study was to determine the prevalence and characteristics of tinnitus and assess the relationship between tinnitus and hearing loss among firefighters and operating engineers, who are exposed to noise on-the-job. The study analyzed existing data from two different populations (154 firefighters and 769 operating engineers) who completed a survey and audiometric tests as part of a hearing loss prevention intervention study. Approximately 40% of both groups reported tinnitus; 34% of firefighters and 59% of operating engineers showed hearing loss at noise-sensitive frequencies (4 kHz and 6 kHz). Firefighters with high frequency hearing loss (odds ratio [OR] = 2.31; 95% confidence interval [CI] = [1.05, 5.11]) and those with perceived impaired hearing status (OR = 3.53; 95% CI = [1.27, 9.80]) were significantly more likely to report tinnitus. Similarly, operating engineers who had hearing loss at both low (OR = 2.10; 95% CI = [1.40, 3.15]) and high frequencies (OR = 2.00; 95% CI = [1.37, 2.90]), and perceived impaired hearing status (OR = 2.17; 95% CI = [1.55, 3.05]) were twice as likely to report tinnitus. This study demonstrated that tinnitus is a considerable problem for noise-exposed workers. Workers with hearing loss demonstrated significantly higher rates of tinnitus. Comprehensive workplace hearing conservation programs should include tinnitus management for noise-exposed workers, along with other key elements such as noise control and hearing protection. PMID:26968456

  20. ECG changes in factory workers exposed to 27.2  MHz radiofrequency radiation.

    Science.gov (United States)

    Chen, Qingsong; Xu, Guoyong; Lang, Li; Yang, Aichu; Li, Shilin; Yang, Liwen; Li, Chaolin; Huang, Hanlin; Li, Tao

    2013-05-01

    To research the effect of 27.2 MHz radiofrequency radiation on electrocardiograms (ECG), 225 female workers operating radiofrequency machines at a shoe factory were chosen as the exposure group and 100 female workers without exposure from the same factory were selected as the control group. The 6 min electric field strength that the female workers were exposed to was 64.0 ± 25.2 V/m (mean ± SD), which exceeded 61 V/m, the International Commission on Non-Ionizing Radiation Protection reference root mean square levels for occupational exposure. A statistical difference was observed between the exposed group and the control group in terms of the rate of sinus bradycardia (χ(2)  = 11.48, P = 0.003). When several known risk factors for cardiovascular disease were considered, including smoking, age, alcohol ingestion habit, and so on, the exposure duration was not an effective factor for ECG changes, sinus arrhythmia, or sinus bradycardia according to α = 0.05, while P = 0.052 for sinus arrhythmia was very close to 0.05. We did not find any statistical difference in heart rate, duration of the QRS wave (ventricular depolarization), or corrected QT intervals (between the start of the Q wave and end of the T wave) between the exposed and control groups. Occupational exposure to radiofrequency radiation was not found to be a cause of ECG changes after consideration of the confounding factors. PMID:23280584

  1. Mercury and selenium in workers previously exposed to mercury vapour at a chloralkali plant.

    OpenAIRE

    Ellingsen, D G; Holland, R I; Thomassen, Y; Landro-Olstad, M; Frech, W.; Kjuus, H

    1993-01-01

    The concentrations of total mercury (B-Hg), inorganic mercury (B-IHg), and methyl mercury (B-MeHg) in whole blood, urinary mercury (U-Hg), and selenium in urine (U-Se) and whole blood (B-Se) were determined in 74 chloralkali workers previously exposed to Hg vapour, and compared with 51 age matched referents. Dental amalgam state, fish consumption, and exposure related indices were studied with regard to the determined elements. A significant relation between the surface of dental amalgam and ...

  2. Surveillance of health care workers exposed to ionising radiation: Rimed pilot study

    International Nuclear Information System (INIS)

    The project so-called RIMED aimed to set up epidemiological surveillance of health care workers exposed to ionizing radiation. A pilot study was conducted in a sample of hospital personnel to examine the possibility of identifying exposed subjects in order to analyse mortality patterns according to occupational characteristics such as medical departments or occupations in a historical cohort. Seven hospitals participated in this pilot study. Health-care workers who had worn a dosimeter up to December 2003 were to be included in this cohort. The subjects' identification data were obtained from the SISERI (Systeme d'information de la surveillance de l'exposition aux rayonnements ionisants - Ionizing Radiation Exposure Monitoring Information System) database managed by the Institut de radioprotection et de surete nucleaire - Radiation Protection and Nuclear Safety Institute (IRSN). The SISERI system was in a 'pilot' phase in 2004. According to SISERI database, a total of 5126 subjects were found to have worn a dosimeter up to December 2003. The subjects' identification data were completed by the administrative services of the hospitals and occupational physicians searched for subjects' occupational data. Information required for the vital status search was satisfactorily completed only for 38% of the cohort subjects. This pilot study showed that obtaining data from SISERI database completed by hospital administrative data in 2004 led to a database of insufficient quality for epidemiological surveillance. The Institut de veille sanitaire (French Institute of Public Health Surveillance) recommends that transmission by the employers of some specific personal or occupational data of the exposed subjects should be made compulsory. In this way, SISERI system should be able to constitute any database with required quality for epidemiological surveillance of ionizing radiation exposed subjects. (authors)

  3. Detection of Sperm DNA Damage in Workers Exposed to Benzene by Modified Single Cell Gel Electrophoresis

    Institute of Scientific and Technical Information of China (English)

    Bo SONG; Zhi-ming CAI; Xin LI; Li-xia DENG; Qiao ZHANG; Lu-kang ZHENG

    2005-01-01

    Objective To assess the effect of benzene on sperm DNA damageMethods Twenty-seven benzene-exposed workers were selected as exposed groupand 35 normal sperm donors as control group. Air concentration of benzene series inworkshop was determined by gas chromatography. As an internal exposure dose ofbenzene, the concentration of trans, trans-muconic acid (ttMA) was determined byhigh performance liquid chromatography. DNA was detected by modified single cellgel electrophoresis (SCGE).Results The air concentrations of benzene, toluene and xylene at the workplace were86.49 ± 2.83 mg/m3, 97.20 ±3.52 mg/m3 and 97.45 ±2.10 mg/m3, respectively.Urinary ttMA in exposed group (1.040 ± 0.617 mg/L) was significantly higher thanthat of control group (0.819 ± 0.157 mg/L). The percentage of head DNA, determinedby modified SCGE method, significantly decreased in the exposed group (n=13, 70.18%± 7.36%) compared with the control (n=16, 90.62% ± 2.94%)(P<0.001).Conclusion The modified SCGE method can be used to investigate the damage ofsperm DNA. As genotoxin and reprotoxins, benzene had direct effect on the germ cellsduring the spermatogenesiss.

  4. Increased mortality in COPD among construction workers exposed to inorganic dust.

    Science.gov (United States)

    Bergdahl, I A; Torén, K; Eriksson, K; Hedlund, U; Nilsson, T; Flodin, R; Järvholm, B

    2004-03-01

    The aim of this study was to find out if occupational exposure to dust, fumes or gases, especially among never-smokers, increased the mortality from chronic obstructive pulmonary disease (COPD). A cohort of 317,629 Swedish male construction workers was followed from 1971 to 1999. Exposure to inorganic dust (asbestos, man-made mineral fibres, dust from cement, concrete and quartz), gases and irritants (epoxy resins, isocyanates and organic solvents), fumes (asphalt fumes, diesel exhaust and metal fumes), and wood dust was based on a job-exposure matrix. An internal control group with "unexposed" construction workers was used, and the analyses were adjusted for age and smoking. When all subjects were analysed, there was an increased mortality from COPD among those with any airborne exposure (relative risk 1.12 (95% confidence interval (CI) 1.03-1.22)). In a Poisson regression model, including smoking, age and the major exposure groups, exposure to inorganic dust was associated with an increased risk (hazard ratio (HR) 1.10 (95% CI 1.06-1.14)), especially among never-smokers (HR 2.30 (95% CI 1.07-4.96)). The fraction of COPD among the exposed attributable to any airborne exposure was estimated as 10.7% overall and 52.6% among never-smokers. In conclusion, occupational exposure among construction workers increases mortality due to chronic obstructive pulmonary disease, even among never-smokers. PMID:15065829

  5. Compensation for damage to workers health exposed to ionizing radiation in Argentina

    International Nuclear Information System (INIS)

    The objective of this report is to analyze the possibility to establish a scheme to compensate damage to workers health exposed to ionizing radiation in Argentina for those cases in which it is possible to assume that the exposure to ionizing radiation is the cause of the cancer suffered by the worker. The proposed scheme is based on the recommendations set out in the 'International Conference on Occupational Radiation Protection: Protecting Workers against Exposure to Ionization Radiation, held in Geneva, Switzerland, August 26-30, 2002. To this end, the study analyzes the present state of scientific knowledge on cancer causation due to genotoxic factors, and the accepted form of the doses-response curve, for the human beings exposure to ionization radiation at low doses with low doses rates. Finally, the labor laws and regulations related to damage compensation; in particular the present Argentine Labor Law; the National Russian Federal Occupational Radiological Health Impairment and Workmen Compensation, the United Kingdom Compensation Scheme for Radiation-linked Diseases and the United States Energy Employees Occupational Illness Compensation Program are described. (author)

  6. Increased mortality in COPD among construction workers exposed to inorganic dust.

    Science.gov (United States)

    Bergdahl, I A; Torén, K; Eriksson, K; Hedlund, U; Nilsson, T; Flodin, R; Järvholm, B

    2004-03-01

    The aim of this study was to find out if occupational exposure to dust, fumes or gases, especially among never-smokers, increased the mortality from chronic obstructive pulmonary disease (COPD). A cohort of 317,629 Swedish male construction workers was followed from 1971 to 1999. Exposure to inorganic dust (asbestos, man-made mineral fibres, dust from cement, concrete and quartz), gases and irritants (epoxy resins, isocyanates and organic solvents), fumes (asphalt fumes, diesel exhaust and metal fumes), and wood dust was based on a job-exposure matrix. An internal control group with "unexposed" construction workers was used, and the analyses were adjusted for age and smoking. When all subjects were analysed, there was an increased mortality from COPD among those with any airborne exposure (relative risk 1.12 (95% confidence interval (CI) 1.03-1.22)). In a Poisson regression model, including smoking, age and the major exposure groups, exposure to inorganic dust was associated with an increased risk (hazard ratio (HR) 1.10 (95% CI 1.06-1.14)), especially among never-smokers (HR 2.30 (95% CI 1.07-4.96)). The fraction of COPD among the exposed attributable to any airborne exposure was estimated as 10.7% overall and 52.6% among never-smokers. In conclusion, occupational exposure among construction workers increases mortality due to chronic obstructive pulmonary disease, even among never-smokers.

  7. Bladder cancer mortality of workers exposed to aromatic amines: a 58-year follow-up.

    Science.gov (United States)

    Pira, Enrico; Piolatto, Giorgio; Negri, Eva; Romano, Canzio; Boffetta, Paolo; Lipworth, Loren; McLaughlin, Joseph K; La Vecchia, Carlo

    2010-07-21

    We previously investigated bladder cancer risk in a cohort of dyestuff workers who were heavily exposed to aromatic amines from 1922 through 1972. We updated the follow-up by 14 years (through 2003) for 590 exposed workers to include more than 30 years of follow-up since last exposure to aromatic amines. Expected numbers of deaths from bladder cancer and other causes were computed by use of national mortality rates from 1951 to 1980 and regional mortality rates subsequently. There were 394 deaths, compared with 262.7 expected (standardized mortality ratio = 1.50, 95% confidence interval = 1.36 to 1.66). Overall, 56 deaths from bladder cancer were observed, compared with 3.4 expected (standardized mortality ratio = 16.5, 95% confidence interval = 12.4 to 21.4). The standardized mortality ratio for bladder cancer increased with younger age at first exposure and increasing duration of exposure. Although the standardized mortality ratio for bladder cancer steadily decreased with time since exposure stopped, the absolute risk remained approximately constant at 3.5 deaths per 1000 man-years up to 29 years after exposure stopped. Excess risk was apparent 30 years or more after last exposure. PMID:20548022

  8. Identification of rounded atelectasis in workers exposed to asbestos by contrast helical computed tomography

    Directory of Open Access Journals (Sweden)

    Terra-Filho M.

    2003-01-01

    Full Text Available Rounded atelectasis (RA is a benign and unusual form of subpleural lung collapse that has been described mostly in asbestos-exposed workers. This form of atelectasis manifests as a lung nodule and can be confused with bronchogenic carcinoma upon conventional radiologic examination. The objective of the present study was to evaluate the variation in contrast uptake in computed tomography for the identification of asbestos-related RA in Brazil. Between January 1998 and December 2000, high-resolution computed tomography (HRCT was performed in 1658 asbestos-exposed workers. The diagnosis was made in nine patients based on a history of prior asbestos exposure, the presence of characteristic (HRCT findings and lesions unchanged in size over 2 years or more. In three of them the diagnosis was confirmed during surgery. The dynamic contrast enhancement study was modified to evaluate nodules and pulmonary masses. All nine patients with RA received iodide contrast according to weight. The average enhancement after iodide contrast was infused, reported as Hounsfield units (HU, increased from 62.5 ± 9.7 to 125.4 ± 20.7 (P < 0.05, with a mean enhancement of 62.5 ± 19.7 (range 40 to 89 and with a uniform dense opacification. In conclusion, in this study all patients with RA showed contrast enhancement with uniform dense opacification. The main clinical implication of this finding is that this procedure does not permit differentiation between RA and malignant pulmonary neoplasm.

  9. [Biomonitoring in workers exposed to pesticides: development and application of method detecting imidacloprid in urine].

    Science.gov (United States)

    Fedorova, N e; Rakitskiy, V n; Goryacheva, Lv; Chistova, A

    2016-01-01

    Imidacloprid is a relatively new insecticide in neonicotinoids chemical class with neuroactivity in insects, being one of the most widely used insecticides in the world. For biomonitoring in workers exposed to pesticides, the authors designed a method detecting low levels of Imidacloprid in urine of operators, based on tandem liquid mass-spectrometry with ionization source--electrostatic dispersion (positive ionization) in multi-reaction monitoring regime with subsidiary ion (mass/charge) 209 for quantitative assessment and ion 175.1 for confirmation onion ratio. The study incorporated diurnal urine, about 100 ml of average sample was frozen and kept at temperature -20C for analysis. Before extraction, the sample was unfrozen, an aliquot of 5 ml was selected, diluted with 5 ml of 0.1% formic acid. The substance was concentrated out of the urine samples via solid-phase extraction with application of cartridges based on octadecylsilane, eluition--1 ml of methanol. Lower limit of Imidacloprid detection in urine is 0.02 ng/ml, of the quantitative assessment--0.1 ng/ ml, linear range of concentrations measured 0.1-10 ng/ml. The method was tested for monitoring in workers exposed to Imidacloprid preparations in natural conditions of pesticides application in agriculture, with various processing technologies. Imidacloprid was identified in urine of two professional operators after work in seed treatment and the subsequent seeding at lower limit of detection (0.02 ng/ml) and 0.34 ng/ml. PMID:27265938

  10. Dose evaluation in occupationally exposed workers through dosimeters ring and wrist type with an anthropomorphic phantom

    International Nuclear Information System (INIS)

    In the Nuclear Medicine service of the Clinica San Pablo (Peru), the occupationally exposed workers carried out the preparation and administration of radiopharmaceuticals to patients, so it is vital to measure the equivalent dose to the hands during the procedures in order to optimize the exposure to the ionizing radiation and execute the Radiological Safety Regulation (D.S. No. 009-97-Em) and the standard IR 002.2012 of radiation protection and safety in nuclear medicine. In this paper was designed and built a hand anthropomorphic phantom made of paraffin following the description given for the standard man, later were placed dosimeters ring and wrist type UD-807 model, Panasonic brand. Then we proceeded to irradiate using vial containers of Tc-99 and I-131. The obtained results showed the difference between the equivalent dose obtained among the ring and wrist dosimeter also getting a dose of 153 mSv /year when working with 99mTc and of 61 mSv /year when working with iodine-131. Was also demonstrated that the ring dosimeter shows the average dose received in the hand with less dispersion. It was found that under the national regulation on Requirements of Radiation Protection and Nuclear Safety in Medicine article 63, indicates that higher doses of 150 mSv /year the occupationally exposed workers should have hand dosimetry. Finally the individual dose limit of 500 mSv /year in extremities can be overcome if adequate radiation protection standards do not apply. (author)

  11. Retrospective cohort mortality study of workers exposed to formaldehyde in the garment industry

    Energy Technology Data Exchange (ETDEWEB)

    Stayner, L.T.; Elliott, L.; Blade, L.; Keenlyside, R.; Halperin, W.

    1988-01-01

    In order to assess the possible human carcinogenicity of formaldehyde we conducted a retrospective cohort mortality study of workers exposed for at least three months to formaldehyde in three garment facilities which produced permanent press garments. A total of 11,030 workers contributing 188,025 person-years were included in the study. Vital status was successfully ascertained through 1982 for over 96% of the cohort. The average (TWA) formaldehyde exposure at the three plants monitored in 1981 and 1984 by NIOSH was 0.15 ppm but past exposures may have been substantially higher. In general, mortality from nonmalignant causes was less than expected. A statistically significant excess in mortality from cancers of the buccal cavity (SMR = 343) and connective tissue (SMR = 364) was observed. Statistically nonsignificant excesses in mortality were observed for cancers of the trachea, bronchus and lung (SMR = 114), pharynx (SMR = 112), bladder (SMR = 145), leukemia and aleukemia (SMR = 113), and other lymphopoietic neoplasms (SMR = 170). Mortality from cancers of the trachea, bronchus and lung was inversely related to duration of exposure and latency. In contrast, mortality from cancers of the buccal cavity, leukemias, and other lymphopoietic neoplasms increased with duration of formaldehyde exposure and/or latency. These neoplasms also were found to be highest among workers first exposed during a time period of high potential formaldehyde exposures in this industry (1955-1962). However, it should be recognized that these findings are based on relatively small numbers and that confounding by other factors may still exist. The results from this investigation, although far from conclusive, do provide evidence of a possible relationship between formaldehyde exposure and the development of upper respiratory cancers (buccal), leukemias, and other lymphopoietic neoplasms in humans.

  12. A retrospective cohort mortality study of workers exposed to formaldehyde in the garment industry.

    Science.gov (United States)

    Stayner, L T; Elliott, L; Blade, L; Keenlyside, R; Halperin, W

    1988-01-01

    In order to assess the possible human carcinogenicity of formaldehyde we conducted a retrospective cohort mortality study of workers exposed for at least three months to formaldehyde in three garment facilities which produced permanent press garments. A total of 11,030 workers contributing 188,025 person-years were included in the study. Vital status was successfully ascertained through 1982 for over 96% of the cohort. The average (TWA) formaldehyde exposure at the three plants monitored in 1981 and 1984 by NIOSH was 0.15 ppm but past exposures may have been substantially higher. In general, mortality from nonmalignant causes was less than expected. A statistically significant excess in mortality from cancers of the buccal cavity (SMR = 343) and connective tissue (SMR = 364) was observed. Statistically nonsignificant excesses in mortality were observed for cancers of the trachea, bronchus and lung (SMR = 114), pharynx (SMR = 112), bladder (SMR = 145), leukemia and aleukemia (SMR = 113), and other lymphopoietic neoplasms (SMR = 170). Mortality from cancers of the trachea, bronchus and lung was inversely related to duration of exposure and latency. In contrast, mortality from cancers of the buccal cavity, leukemias, and other lymphopoietic neoplasms increased with duration of formaldehyde exposure and/or latency. These neoplasms also were found to be highest among workers first exposed during a time period of high potential formaldehyde exposures in this industry (1955-1962). However, it should be recognized that these findings are based on relatively small numbers and that confounding by other factors may still exist. The results from this investigation, although far from conclusive, do provide evidence of a possible relationship between formaldehyde exposure and the development of upper respiratory cancers (buccal), leukemias, and other lymphopoietic neoplasms in humans.

  13. Prevalence of rhinitis symptoms among textile industry workers exposed to cotton dust

    Directory of Open Access Journals (Sweden)

    Dantas, Ivan de Picoli

    2013-01-01

    Full Text Available Introduction: The respiratory tract is one of the main points of entry of foreign substances into the body. Because of its location, the respiratory tract is heavily exposed to harmful agents, such as gases, vapors, or aerosols. Aim: Our objective was to evaluate the symptoms of occupational rhinitis in workers exposed to cotton dust. Method: The prospective study population consisted of workers from the "Nova Esperança" Cooperative of Nova Odessa (Sao Paulo, who were studied between September and December 2008. Data were collected through an individually and privately answered questionnaire designed by the author considering the clinical criteria for rhinitis. Results: Using the questionnaire, we evaluated a total of 124 workers. Among these patients, 63.7% complained of nasal obstruction, 57.2% of nasal itching, 46.7% of rhinorrhea, and 66.1% of sneezing. Of the patients considered to have very serious symptoms, 9% had nasal obstruction; 9%, itching; 4%, rhinorrhea; and 6.4%, sneezing. Discussion: Aerosol agents in the environment can clearly aggravate and even initiate rhinitis. From the standpoint of pathogenesis, the mechanisms of classical allergic airway inflammation involving mast cells, IgE, histamine, eosinophils, and lymphocytes may be responsible for the development of rhinitis after exposure to high molecular weight allergens such as proteins derived from animals and plants. This study showed a strong relationship between the occupational exposures associated with work in the cotton textile industry and the symptoms of rhinitis. Conclusion: Analysis of the data clearly showed the occurrence of rhinitis symptoms in these patients, demonstrating that the prevention and treatment of this condition in the workplace is extremely important.

  14. Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes

    Science.gov (United States)

    Mimaki, Sachiyo; Totsuka, Yukari; Suzuki, Yutaka; Nakai, Chikako; Goto, Masanori; Kojima, Motohiro; Arakawa, Hirofumi; Takemura, Shigekazu; Tanaka, Shogo; Marubashi, Shigeru; Kinoshita, Masahiko; Matsuda, Tomonari; Shibata, Tatsuhiro; Nakagama, Hitoshi; Ochiai, Atsushi; Kubo, Shoji; Nakamori, Shoji; Esumi, Hiroyasu; Tsuchihara, Katsuya

    2016-01-01

    Cholangiocarcinoma is a relatively rare cancer, but its incidence is increasing worldwide. Although several risk factors have been suggested, the etiology and pathogenesis of the majority of cholangiocarcinomas remain unclear. Recently, a high incidence of early-onset cholangiocarcinoma was reported among the workers of a printing company in Osaka, Japan. These workers underwent high exposure to organic solvents, mainly haloalkanes such as 1,2-dichloropropane (1,2-DCP) and/or dichloromethane. We performed whole-exome analysis on four cases of cholangiocarcinoma among the printing workers. An average of 44.8 somatic mutations was detected per Mb in the genome of the printing workers’ cholangiocarcinoma tissues, approximately 30-fold higher than that found in control common cholangiocarcinoma tissues. Furthermore, C:G-to-T:A transitions with substantial strand bias as well as unique trinucleotide mutational changes of GpCpY to GpTpY and NpCpY to NpTpY or NpApY were predominant in all of the printing workers’ cholangiocarcinoma genomes. These results were consistent with the epidemiological observation that they had been exposed to high concentrations of chemical compounds. Whole-genome analysis of Salmonella typhimurium strain TA100 exposed to 1,2-DCP revealed a partial recapitulation of the mutational signature in the printing workers’ cholangiocarcinoma. Although our results provide mutational signatures unique to occupational cholangiocarcinoma, the underlying mechanisms of the disease should be further investigated by using appropriate model systems and by comparison with genomic data from other cancers. PMID:27267998

  15. Cytogenetic biomonitoring of occupationally exposed workers to ashes from burning of sugar cane in Ahome, Sinaloa, México.

    Science.gov (United States)

    Martínez-Valenzuela, Carmen; Rodríguez-Quintana, Ana Rosa; Meza, Enrique; Waliszewski, Stefan M; Amador-Muñóz, Omar; Mora-Romero, Arlene; Calderón-Segura, María Elena; Félix-Gastélum, Rubén; Rodríguez-Romero, Isabel; Caba, Mario

    2015-09-01

    Burning the sugar cane field before harvesting has a negative impact on both air and human health, however this issue had not been explored in Mexico. The objective of this work was to determine the chromosomal damage in workers from sugar cane burning fields in Sinaloa, México. To this purpose, we analyzed 1000 cells of buccal exfoliated epithelia from 60 exposed workers and 60 non-exposed controls to determine micronucleus frequencies and other nuclear abnormalities. The results indicated significant higher values of micronucleus and nuclear abnormalities such as binucleate cells, pyknosis, karyolysis, chromatin condensation and nuclear buds frequencies in the exposed subjects compared to those that were not exposed. Our data indicates that sugar cane burning, that generates polycyclic aromatic hydrocarbons, represents a genotoxic risk for workers in this important sugar cane producing area in Mexico. PMID:26245813

  16. Association Between Polymorphisms of DNA Repair Gene XRCC1 and DNA Damage in Asbestos-Exposed Workers

    Institute of Scientific and Technical Information of China (English)

    XIAO-HONG ZHAO; GUANG JIA; YONG-QUAN LIU; SHAO-WEI LIU; LEI YAN; YU JIN; NIAN LIU

    2006-01-01

    Objective To compare the asbestos-induced DNA damage and repair capacities of DNA damage between 104 asbestos exposed workers and 101 control workers in Qingdao City of China and to investigate the possible association between polymorphisms in codon 399 of XRCC1 and susceptibility to asbestosis. Methods DNA damage levels in peripheral bloodlymphocytes were determined by comet assay, and XRCC 1 genetic polymorphisms of DNA samples from 51 asbestosis cases and 53 non-asbestosis workers with a similar asbestos exposure history were analyzed by PCR/RFLP. Results The basal comet scores (3.95±2.95) were significantly higher in asbestos-exposed workers than in control workers (0.10±0.28). After 1 h H2O2 stimulation, DNA damage of lymphocytes exhibited different increases. After a 4 h repair period, the comet scores were 50.98±19.53 in asbestos-exposed workers and 18.32±12.04 in controls. The residual DNA damage (RD) was significantly greater (P<0.01) in asbestos-exposed workers (35.62%) than in controls (27.75%). XRCC1 genetic polymorphism in 104 asbestos-exposed workers was not associated with increased risk of asbestosis. But compared with polymorphisms in the DNA repair gene XRCC1 (polymorphisms in codon 399) and the DNA damage induced by asbestos, the comet scores in asbestosis cases with Gln/Gln, Gln/Arg, and Arg/Arg were 40.26±18.94, 38.03±28.22, and 32.01±11.65, respectively, which were higher than those in non-asbestosis workers with the same genotypes (25.58±11.08, 37.08±14.74, and 29.38±10.15). There were significant differences in the comet scores between asbestosis cases and non-asbestosis workers with Gln/Gln by Student's t-test (P<0.05 or 0.01). The comet scores were higher in asbestosis workers with Gln/Gln than in those with Arg/Arg and in non-asbestosis workers exposed to asbestos, but without statistically significant difference. Conclusions Exposure to asbestos may be related to DNA damage or the capacity of cells to repair H2O2-induced

  17. Genotoxic damage in mine workers exposed to diesel exhaust, and the effects of glutathione transferase genotypes.

    Science.gov (United States)

    Knudsen, L E; Gaskell, M; Martin, E A; Poole, J; Scheepers, P T J; Jensen, A; Autrup, H; Farmer, P B

    2005-06-01

    significant differences between surface and underground workers were found in this sub-sample with respect to the minor, unidentified adducts that had similar chromatographic properties to 1-NP adducts, and smoking did not have any effect on adduct levels. No significant effects of the genotypes of GSTM1, GSTP1 and GSTT1 on DNA-adducts and on DNA damage as measured by the Comet assay were found in the total study group. The study confirms an increased level of DNA damage in workers exposed to exhaust from truck-driving in the mine. However, the results of the environmental and biological monitoring of 1-NP did not correlate, suggesting that inhalation exposure to diesel exhaust is not reflected by an increase in 1-NP-DNA-adduct levels and/or that factors other than occupational exposure to diesel exhaust are primary determinants of these DNA-adduct levels. PMID:15876548

  18. Shorter telomere length in peripheral blood lymphocytes of workers exposed to polycyclic aromatic hydrocarbons.

    Science.gov (United States)

    Pavanello, Sofia; Pesatori, Angela-C; Dioni, Laura; Hoxha, Mirjam; Bollati, Valentina; Siwinska, Ewa; Mielzyńska, Danuta; Bolognesi, Claudia; Bertazzi, Pier-Alberto; Baccarelli, Andrea

    2010-02-01

    Shorter telomere length (TL) in peripheral blood lymphocytes (PBLs) is predictive of lung cancer risk. Polycyclic aromatic hydrocarbons (PAHs) are established lung carcinogens that cause chromosome instability. Whether PAH exposure and its molecular effects are linked with shorter TL has never been evaluated. In the present study, we investigated the effect of chronic exposure to PAHs on TL measured in PBLs of Polish male non-current smoking cokeoven workers and matched controls. PAH exposure and molecular effects were characterized using measures of internal dose (urinary 1-pyrenol), effective dose [anti-benzo[a]pyrene diolepoxide (anti-BPDE)-DNA adduct], genetic instability (micronuclei, MN) and DNA methylation [p53 promoter and Alu and long interspersed nuclear element-1 (LINE-1) repetitive elements, as surrogate measures of global methylation] in PBLs. TL was measured by real-time polymerase chain reaction. Cokeoven workers were heavily exposed to PAHs (79% exceeded the urinary 1-pyrenol biological exposure index) and exhibited lower TL (P = 0.038) than controls, as well as higher levels of genetic and chromosomal alterations [i.e. anti-BPDE-DNA adduct and MN (P < 0.0001)] and epigenetic changes [i.e. p53 gene-specific promoter and global methylation (P worker (P = 0.039) and in all subjects with higher levels of anti-BPDE-DNA adduct (P = 0.042), p53 hypomethylation (P = 0.005) and MN (P = 0.009). In multivariate analysis, years of work in cokery (P = 0.008) and p53 hypomethylation (P = 0.001) were the principal determinants of shorter TL. Our results indicate that shorter TL is associated with chronic PAH exposure. The interrelations with other genetic and epigenetic mechanisms in our data suggest that shorter TL could be a central event in PAH carcinogenesis.

  19. Survival times of women radium dial workers first exposed before 1930

    International Nuclear Information System (INIS)

    Life table methods were applied to survival data on U.S. women radium dial workers in order to compare observed and expected deaths as a function of time after exposure to radium. The study population consisted of 1235 workers employed in the industry before 1930 for whom age and year of death, withdrawal or loss from the study were known. Expected deaths were estimated from age- and time-specific death rates for U.S. white females. The closing year for analysis was 1976, so observation times of 45 to 60 years were possible. For all causes, 529 deaths before age 85 were observed versus 461 expected, and the cumulative survival of the population was significantly less than expected at 10 and more years after first employment. Estimates were made of the net survival probabilities after elimination of risk due to the well-known radium-related malignancies, i.e. bone sarcomas and carcinomas of the paranasal sinuses and the mastoid air cells. There were 455 observed deaths from other causes versus 460 expected, and there was no significant difference between observed and expected cumulative net survival at one-year intervals from zero to 59 years after first employment. These findings indicate that only the known radium-related malignancies contributed significantly to life shortening of the exposed population as a whole, but the presence of other radium-related causes of death may yet be detectable by examination of specific risks as a function of dose. (author)

  20. PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos

    International Nuclear Information System (INIS)

    Animal studies have shown that paraoxonase 1 (PON1) genotype can influence susceptibility to the organophosphorus pesticide chlorpyrifos (CPF). However, Monte Carlo analysis suggests that PON1 genotype may not affect CPF-related toxicity at low exposure conditions in humans. The current study sought to determine the influence of PON1 genotype on the activity of blood cholinesterase as well as the effect of CPF exposure on serum PON1 in workers occupationally exposed to CPF. Saliva, blood and urine were collected from agricultural workers (n = 120) from Egypt's Menoufia Governorate to determine PON1 genotype, blood cholinesterase activity, serum PON1 activity towards chlorpyrifos-oxon (CPOase) and paraoxon (POase), and urinary levels of the CPF metabolite 3,5,6-trichloro-2-pyridinol (TCPy). The PON1 55 (P ≤ 0.05) but not the PON1 192 genotype had a significant effect on CPOase activity. However, both the PON1 55 (P ≤ 0.05) and PON1 192 (P ≤ 0.001) genotypes had a significant effect on POase activity. Workers had significantly inhibited AChE and BuChE after CPF application; however, neither CPOase activity nor POase activity was associated with ChE depression when adjusted for CPF exposure (as determined by urinary TCPy levels) and stratified by PON1 genotype. CPOase and POase activity were also generally unaffected by CPF exposure although there were alterations in activity within specific genotype groups. Together, these results suggest that workers retained the capacity to detoxify chlorpyrifos-oxon under the exposure conditions experienced by this study population regardless of PON1 genotype and activity and that effects of CPF exposure on PON1 activity are minimal. -- Highlights: ► CPF exposure resulted in an increase in TCPy and decreases in BuChE and AChE. ► CPOase activity decreased in subjects with the PON1 55LM and PON1 55 MM genotypes. ► Neither PON1 genotype nor CPOase activity had an effect on BuChE or AChE inhibition.

  1. PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos

    Energy Technology Data Exchange (ETDEWEB)

    Ellison, Corie A., E-mail: cellison@buffalo.edu [Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States); Crane, Alice L., E-mail: alcrane@buffalo.edu [Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States); Bonner, Matthew R., E-mail: mrbonner@buffalo.edu [Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY 14214 (United States); Knaak, James B., E-mail: jbknaak@aol.com [Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States); Browne, Richard W., E-mail: rwbrowne@buffalo.edu [Department of Biotechnical and Clinical Laboratory Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States); Lein, Pamela J., E-mail: pjlein@ucdavis.edu [Department of Molecular Biosciences, University of California School of Veterinary Medicine, Davis, CA 95618 (United States); Olson, James R., E-mail: jolson@buffalo.edu [Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States); Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY 14214 (United States)

    2012-12-15

    Animal studies have shown that paraoxonase 1 (PON1) genotype can influence susceptibility to the organophosphorus pesticide chlorpyrifos (CPF). However, Monte Carlo analysis suggests that PON1 genotype may not affect CPF-related toxicity at low exposure conditions in humans. The current study sought to determine the influence of PON1 genotype on the activity of blood cholinesterase as well as the effect of CPF exposure on serum PON1 in workers occupationally exposed to CPF. Saliva, blood and urine were collected from agricultural workers (n = 120) from Egypt's Menoufia Governorate to determine PON1 genotype, blood cholinesterase activity, serum PON1 activity towards chlorpyrifos-oxon (CPOase) and paraoxon (POase), and urinary levels of the CPF metabolite 3,5,6-trichloro-2-pyridinol (TCPy). The PON1 55 (P ≤ 0.05) but not the PON1 192 genotype had a significant effect on CPOase activity. However, both the PON1 55 (P ≤ 0.05) and PON1 192 (P ≤ 0.001) genotypes had a significant effect on POase activity. Workers had significantly inhibited AChE and BuChE after CPF application; however, neither CPOase activity nor POase activity was associated with ChE depression when adjusted for CPF exposure (as determined by urinary TCPy levels) and stratified by PON1 genotype. CPOase and POase activity were also generally unaffected by CPF exposure although there were alterations in activity within specific genotype groups. Together, these results suggest that workers retained the capacity to detoxify chlorpyrifos-oxon under the exposure conditions experienced by this study population regardless of PON1 genotype and activity and that effects of CPF exposure on PON1 activity are minimal. -- Highlights: ► CPF exposure resulted in an increase in TCPy and decreases in BuChE and AChE. ► CPOase activity decreased in subjects with the PON1 55LM and PON1 55 MM genotypes. ► Neither PON1 genotype nor CPOase activity had an effect on BuChE or AChE inhibition.

  2. Estudo da ototoxicidade em trabalhadores expostos a organofosforados Ototoxicity study in workers exposed to organophosphate

    Directory of Open Access Journals (Sweden)

    Ana Cristina Hiromi Hoshino

    2008-12-01

    Full Text Available A exposição ocupacional e ambiental aos agrotóxicos evidencia-se como um grave problema de Saúde Pública em nosso país. Entre os sintomas apresentados, a tonteira se destaca, em decorrência de uma provável ação tóxica. OBJETIVO: O objetivo do estudo é caracterizar os resultados do exame vestibular de trabalhadores rurais expostos ocupacionalmente e ambientalmente aos agrotóxicos organofosforados. MATERIAL E MÉTODO: Foi realizado um estudo de coorte com corte transversal em 18 trabalhadores rurais de Teresópolis, RJ. A faixa etária variou de 16 a 59 anos com uma média de 39,6 anos, sendo 5 trabalhadores do sexo masculino e 13 do sexo feminino. Foram utilizados três questionários com perguntas relacionadas à saúde geral e auditiva e perguntas específicas à tonteira e suas relações com o trabalho. Todos os trabalhadores passaram por uma avaliação clínica e realizaram os exames vectoeletronistagmografia e audiometria. RESULTADOS: Os resultados mostraram que 16 trabalhadores apresentaram alterações do equilíbrio corporal de tipo periférico irritativo e 7 trabalhadores apresentaram perdas auditivas do tipo neurossensorial, sugerindo que os agrotóxicos induzem alterações do sistema vestibular através de uma intoxicação lenta e silenciosa. CONCLUSÕES: O olhar clínico sobre esta população exposta a substâncias neuro-ototóxicas requer uma abordagem interdisciplinar, assegurando uma intervenção terapêutica e preventiva eficaz.Occupational and environmental exposure to agricultural pesticides represent an important health care problem in our country. Among the symptoms presented, dizziness stands out, because of a probable toxic action. AIM: The goal of our study was to characterize vestibular test results from rural workers occupationally and environmentally exposed to organophosphates used in agricultural pesticides. MATERIALS AND METHODS: We carried out a cohort cross-sectional study with 18 rural workers

  3. Clinical treatment adherence of health care workers and students exposed to potentially infectious biological material

    Directory of Open Access Journals (Sweden)

    Maria Cristina Mendes de Almeida

    2015-04-01

    Full Text Available OBJECTIVE To assess adherence to clinical appointments by health care workers (HCW and students who suffered accidents with potentially infectious biological material. METHOD A retrospective cross-sectional study that assessed clinical records of accidents involving biological material between 2005 and 2010 in a specialized unit. RESULTS A total of 461 individuals exposed to biological material were treated, of which 389 (84.4% were HCWs and 72 (15.6% students. Of the 461 exposed individuals, 307 (66.6% attended a follow-up appointment. Individuals who had suffered an accident with a known source patient were 29 times more likely to show up to their scheduled follow-up appointments (OR: 29.98; CI95%: 16.09-55.83. CONCLUSION The predictor in both univariate and multivariate analyses for adherence to clinical follow-up appointment was having a known source patient with nonreactive serology for the human immunodeficiency virus and/or hepatitis B and C.

  4. Association between sperm DNA integrity and seminal plasma antioxidant levels in health workers occupationally exposed to ionizing radiation

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Dayanidhi; Salian, Sujith Raj; Kalthur, Guruprasad; Uppangala, Shubhashree; Kumari, Sandhya [Division of Clinical Embryology, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal 576104 (India); Challapalli, Srinivas [Department of Radiotherapy, Kasturba Medical College, Mangalore (India); Chandraguthi, Shrinidhi Gururajarao [Department of Radiotherapy and Oncology, Kasturba Medical College, Manipal (India); Jain, Navya; Krishnamurthy, Hanumanthappa [National Centre for Biological Sciences, Bangalore (India); Kumar, Pratap [Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal (India); Adiga, Satish Kumar, E-mail: satish.adiga@manipal.edu [Division of Clinical Embryology, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal 576104 (India)

    2014-07-15

    There is a paucity of data regarding the association between occupational radiation exposure and risk to human fertility. Recently, we provided the first evidence on altered sperm functional characteristics, DNA damage and hypermethylation in radiation health workers. However, there is no report elucidating the association between seminal plasma antioxidants and sperm chromatin integrity in occupationally exposed subjects. Here, we assessed the seminal plasma antioxidants and lipid peroxidation level in 83 men who were occupationally exposed to ionizing radiation and then correlated with the sperm chromatin integrity. Flow cytometry based sperm chromatin integrity assay revealed a significant decline in αt value in the exposed group in comparison to the non-exposed group (P<0.0001). Similarly, both total and reduced glutathione levels and total antioxidant capacity in the seminal plasma were significantly higher in exposed group than the non-exposed group (P<0.01, 0.001 and 0.0001, respectively). However, superoxide dismutase level and malondialdehyde level, which is an indicator of lipid peroxidation in the seminal plasma, did not differ significantly between two groups. The total antioxidant capacity (TAC) and GSH level exhibited a positive correlation with sperm DNA integrity in exposed subjects. To conclude, this study distinctly shows that altered sperm chromatin integrity in radiation health workers is associated with increase in seminal plasma antioxidant level. Further, the increased seminal plasma GSH and TAC could be an adaptive measure to tackle the oxidative stress to protect genetic and functional sperm deformities in radiation health workers. - Highlights: • Seminal plasma antioxidants were measured in men occupationally exposed to radiation. • Sperm chromatin integrity was significantly affected in the exposed group. • Glutathione and total antioxidant capacity was significantly higher in exposed group. • Sperm DNA damage in exposed subjects

  5. Susceptibility to DNA damage in workers occupationally exposed to pesticides, to tannery chemicals and to coal dust during mining.

    Science.gov (United States)

    Kvitko, Katia; Bandinelli, Eliane; Henriques, João A P; Heuser, Vanina D; Rohr, Paula; da Silva, Fernanda R; Schneider, Naye Balzan; Fernandes, Simone; Ancines, Camile; da Silva, Juliana

    2012-12-01

    Our mutagenesis group has been studying with important economic drivers of our state, such as agriculture, the foot-wear and leather industry and open-cast coal mining. Working conditions in these sectors have potentially harmful to humans. The aim of these studies is to determine the health risk of workers by biomonitoring subjects exposed to genotoxic agents. The main results of our studies with vineyard farmers we observed a high rate of MN and DNA damage in individuals exposed to pesticides (p footwear and tannery workers showed a significant increase in the mean ID for the solvent-based adhesive (p < 0.001) group in comparison to the water-based adhesive group and control (p < 0.05). For open-cast coal mine workers, the EBCyt indicated a significant increase in nuclear bud frequency and cytokinetic defects in the exposed group compared to the non-exposed group (p < 0.0001). We were able to associate specific genetic susceptibility with each type of exposure and with the non-use or improper use of personal protection equipment and diet adequacy. These results show how important the continuous education of exposed workers is to minimizing the effect of the occupational exposure and the risk of disease associated with the work. PMID:23413045

  6. Evaluation of DNA damage in agricultural workers exposed to pesticides using single cell gel electrophoresis (comet assay

    Directory of Open Access Journals (Sweden)

    Raminderjeet Kaur

    2011-01-01

    Full Text Available Background : Pesticides are used in agriculture to protect crops, but they pose a potential risk to farmers and environment. The aim of the present study is to investigate the relation between the occupational exposure to various pesticides and the presence of DNA damage. Materials and Methods : Blood samples of 210 exposed workers (after a day of intense spraying and 50 control subjects belonging to various districts of Punjab (India were evaluated using Comet assay. Sixty workers who showed DNA damage were selected for follow up at 5-6 months after the first sampling during a low or null spraying period. Results : Significant differences were found in DNA damage between freshly exposed workers and controls and freshly exposed and followed up cases. There was significant increase in the comet parameters viz. mean comet tail length and frequency of cells showing migration in exposed workers as compared to controls (72.22 ± 20.76 vs. 46.92 ± 8.17, P<0.001; 31.79 vs. 5.77, P<0.001. In the second samples, followed up cases showed significant decrease in frequency of damaged cells as compared to freshly exposed workers of first sampling (P<0.05. The confounding factors such as variable duration of pesticide exposure, age, smoking, drinking and dietary habits etc which were expected to modulate the damage, were instead found to have no significant effect on DNA fragmentation. Conclusion : The evidence of a genetic hazard related to exposure resulting from the intensive use of pesticides stresses the need for educational programs for agricultural workers to reduce the use of chemicals in agriculture.

  7. Association of HSP70 and genotoxic damage in lymphocytes of workers exposed to coke-oven emission

    OpenAIRE

    Xiao, Chengfeng; Chen, Sheng; Li, Jizhao; Hai, Tao; Lu, Qiaofa; Sun, Enling; Wang, Ruibo; Tanguay, Robert M.; Wu, Tangchun

    2002-01-01

    Heat shock proteins (Hsps) have been reported to protect cells, tissues, and organisms against damage from a wide variety of stressful stimuli. Whether they protect against deoxyribonucleic acid (DNA) damage in individuals exposed to environmental stresses and chemical carcinogens is unknown. In the study, we investigated the association between Hsp70 levels (the most abundant mammalian Hsp) and genotoxic damage in lymphocytes of workers exposed to coke-oven emission using Western dot blot an...

  8. Health impacts of exposure to second hand smoke (SHS amongst a highly exposed workforce: survey of London casino workers

    Directory of Open Access Journals (Sweden)

    Gilmore Anna B

    2007-09-01

    Full Text Available Abstract Background Casino workers are exposed to high levels of secondhand smoke (SHS at work, yet remain at risk of being excluded from smoke-free legislation around the world. If the prime motivation for smoke-free legislation is the protection of workers, then a workforce experiencing ill-health associated with SHS exposure should not be excluded from legislation. This study aimed to determine the prevalence of respiratory and sensory irritation symptoms among a sample of casino workers, to identify any association between the reporting of symptoms and exposure to SHS at work, and to compare the prevalence of symptoms with that in other workers exposed to SHS. Methods A postal questionnaire survey of 1568 casino workers in London. Using multivariate analysis we identified predictors of respiratory and sensory irritation symptoms. Results 559 workers responded to the questionnaire (response of 36%. 91% of casino workers reported the presence of one or more sensory irritation symptoms in the previous four weeks, while the figure was 84% for respiratory symptoms. The presence of one or more sensory irritation symptoms was most strongly associated with reporting the highest exposure to SHS at work (OR 3.26; 1.72, 6.16. This was also true for reporting the presence of one or more respiratory irritation symptoms (OR 2.24; 1.34, 3.74. Prevalence of irritation symptoms in the casino workers was in general appreciably higher than that reported in studies of bar workers. Conclusion Our research supports the need for comprehensive smoke-free legislation around the world, covering all indoor workplaces including casinos.

  9. Influence of age and sex on hearing threshold levels in workers exposed to different intensity levels of occupational noise

    Energy Technology Data Exchange (ETDEWEB)

    Szanto, C.; Ionescu, M.

    1983-01-01

    The influence of age, sex and duration of exposure on hearing threshold level (HTL) was assessed in male and female workers exposed to occupational noise. The noise intensities were of 84 and 98 dB(A) continuous equivalent level. Large differences were noted between males and females exposed to 98 dB(A) as well as between males exposed to 98 and 83 dB(A). We concluded that exposure to 98 dB(A) accelerates the evolution of hearing loss, this trend being more pronounced in males. The 83-dB(A) intensity apparently induces a hearing loss above the values due to socioacusis. To evaluate the noxious effect of noise, the HTLs obtained in the group exposed to 98 and 83-dB(A) were compared to those of the non-exposed group of Royster and Thomas. The highest difference was found in males exposed to 98 dB(A).

  10. Analysis of micronuclei of the oral epithelium in workers of a banana zone exposed to pesticides

    International Nuclear Information System (INIS)

    The following study was realized with workers of the zone of Guapiles (Limon, Costa Rica), to determine the possible damage to the genetic material occasioned by labour exhibition to pesticides. The presence of micronuclei in cells of the oral epithelium was used as a biomarcador of effect . Besides, an analysis of frequency of other abnormalities was made in the nucleus of the epithelial cells, which can be an indication of genotoxicity or cytotoxicity. The group of women exposed to pesticides (cases) was formed by workers of packing plants of different independent banana states. The group of women who constituted the group of control were persons that neither them nor their spouses or companions had never worked at agricultural labours and that had not lived inside a banana estate. The samples of the controls were gathered not only from women who are employed at the Hospital of Guapiles, but also from patients who were expecting to be attended in the external consultation of the same hospital, or, in the Healthy Child consultation in the health center of the same city. It is the first time that a study of control-case is done in the country to detect genotoxicidad, using micronuclei of the oral epithelium (MNOE) as a biomarcador. The participants were interviewed to obtain information about his or her customs and family history that could be relevant for the study. The preparation and the analysis of the cells of the oral epithelium of every individual was done in the laboratories of the Instituto de Investigaciones en Salud (INISA), of the Universidad de Costa Rica. Although there are indications of cytotoxic and genotoxicity in the controls showed by an increase of the frequencies of other nuclear abnormalities, the results demonstrated that there is not a significant increase in MNOE's frequency between the group of cases and of controls. (Author)

  11. Mutagenic activity and metabolites in the urine of workers exposed to trinitrotoluene (TNT).

    Science.gov (United States)

    Ahlborg, G; Einistö, P; Sorsa, M

    1988-05-01

    Urine samples taken after work and after a free weekend from 50 workers employed in various activities in a chemical plant manufacturing explosives were analysed. On the basis of hygienic surveys, the subjects were divided into three categories of exposure to trinitrotoluene (TNT). The urine analyses consisted of gas chromatographic identification of TNT and its two metabolites, 4-ADNT and 2-ADNT, and a determination of the mutagenic activity. Two frame shift detector strains of Salmonella typhimurium were used, TA 98 and TA 98 NR, the latter being deficient in endogenous nitroreductase activity. On the basis of previous results on TNT mutagenicity, no exogeneous metabolic system was used to test the urine concentrates. Both tester strains showed that the mean urinary mutagenic activity was higher in the after work samples than in post weekend samples from the same subjects, showing that bacterial nitroreductase activity was not significantly responsible for the mutagenicity, although the response was higher with strain TA 98 than with TA 98 NR. The interindividual variation in urine mutagenicity was high, however, and the difference between the two sampling times was statistically significant (p less than 0.05) only for the high exposed group (workers in trotyl foundry and sieve house). Correlation between urinary mutagenicity and concentration of TNT in urine was poor; correlation was significant only with the urinary concentration of 4-ADNT. The correlation between urinary TNT and both metabolites was good (p less than 0.001). These results suggest that analysis of 4-ADNT in urine would be a sufficient biological measure for controlling exposure to TNT.

  12. Dose received by occupationally exposed workers at a nuclear medicine department

    Energy Technology Data Exchange (ETDEWEB)

    Avila, O.; Sanchez-Uribe, N. A.; Rodriguez-Laguna, A.; Medina, L. A.; Estrada, E.; Buenfil, A. E.; Brandan, M. E. [Instituto Nacional de Investigaciones Nucleares, AP 18-1027, 11801, DF (Mexico); Instituto Nacional de Investigaciones Nucleares, AP 18-1027, 11801, DF (Mexico) and Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, AP 70-542, 04510, DF (Mexico); Instituto Nacional de Cancerologia (INCan), Av. San Fernando No.22, C.P. 14080 (Mexico); Instituto de Fisica, Universidad Nacional Autonoma de Mexico, AP 20-364, 01000 DF (Mexico) and Unidad de Investigacion Biomedica en Cancer INCan-UNAM, Av. San Fernando No.22 C.P. 4080 (Mexico); Instituto Nacional de Cancerologia (INCan), Av. San Fernando No.22, C.P. 14080 (Mexico); Instituto de Fisica, Universidad Nacional Autonoma de Mexico, AP 20-364, 01000 DF (Mexico)

    2012-10-23

    Personal Dose Equivalent (PDE) values were determined for occupational exposed workers (OEW) at the Nuclear Medicine Department (NMD) of 'Instituto Nacional de Cancerologia' (INCan), Mexico, using TLD-100 thermoluminescent dosemeters. OEW at NMD, INCan make use of radiopharmaceuticals for diagnosis and treatment of diseases. Radionuclides associated to a pharmaceutical compound used at this Department are {sup 131}I, {sup 18}F, {sup 68}Ga, {sup 99m}Tc, {sup 111}In and {sup 11}C with main gamma emission energies between 140 and 511 keV. Dosemeter calibration was performed at the metrology department of 'Instituto Nacional de Investigaciones Nucleares' (ININ), Mexico. Every occupational worker used dark containers with three dosimeters which were replaced monthly for a total of 5 periods. Additionally, control dosemeters were also placed at a site free of radioactive sources in order to determine the background radiation. Results were adjusted to find PDE/day and estimating annual PDE values in the range between 2 mSv (background) and 9 mSv. The mean annual value is 3.51 mSv and the standard deviation SD is 0.78 mSv. Four of the 16 OEW received annual doses higher than the average +1 SD (4.29 mSv). Results depend on OEW daily activities and were consistent for each OEW for the 5 studied periods as well as with PDE values reported by the firm that performs the monthly service. All obtained values are well within the established annual OEW dose limit stated in the {sup R}eglamento General de Seguridad Radiologica{sup ,} Mexico (50 mSv), as well as within the lower limit recommended by the 'International Commission on Radiation Protection' (ICRP), report no.60 (20 mSv). These results verify the adequate compliance of the NMD at INCan, Mexico with the norms given by the national regulatory commission.

  13. Health implication among occupational exposed workers in a chromium alloy factory,Thailand

    Institute of Scientific and Technical Information of China (English)

    S. Muttamara; Shing Tet Leong

    2004-01-01

    This study was conducted to assess the occupational exposure and its health impact on the chromium alloyworkers. Environmental and biological monitoring, noise and audiometry measurements were done to evaluate theexposure levels in the factory. A total of 112 non-smoking workers were monitored from July 2001 to August 2002.The results showed that most of the chromium and lead exposures in the factory were below the ACGIH-TWA of 50μg/m3 for chromium( Ⅵ ) and OSHA-PEL of 50 μg/m3 for lead. The highest chromium(7.25 ± 0. 16 μg/m3 ) and lead(14.50 ± 0.29 μg/m3) concentrations were measured in the vibro room. The results indicated that elevatedconcentrations of chromium and lead were found in both blood and urine samples especially in those areas whichwere characterized by poor ventilation. The metal contents in blood and urine samples were significantly correlatedwith airborne metal concentrations in the factory. The result demonstrated that blood and urinary levels amongworkers were associated with increasing age and duration of exposure.The background noise level of the factory ranged from 67.6 to 89.2 dBA and was frequently higher than thethreshold limit value for noise(90 dBA). According to the audiometric test, the exposed workers showed signs ofnoise-induced hearing loss. Noise at work continued to be an important factor to hearing loss among exposedworkers. In our statistical analysis, a significant hearing loss was established on age effect and year of exposureamong the workforce.

  14. Study of hematological indices in tannery workers exposed to chromium in Sheikhupura (Pakistan).

    Science.gov (United States)

    Ramzan, Muhammad; Malik, Muhammad Anwar; Iqbal, Zaheer; Arshad, Najma; Khan, Shafaat Yar; Arshad, Muhammad

    2011-10-01

    Chromium (Cr), being an excellent tanning agent, is widely used in the leather industry and tannery workers (TW) are exposed to it either in the form of inorganic Cr(III) compounds or Cr bound to proteins (leather dust) in the process of leather production. During the present study, the effect of Cr on the hematological indices in TW was evaluated. In this study, hematological indices of 92 male TW aged 20-60 years were compared with 79 control males who hardly had a chance of exposure to chromium. Both groups were subdivided into four age groups with an interval of 10: group A, 20-29 years; group B, 30-39 years; group C, 40-49 years; group D, 50-60 years. Total erythrocyte count (TEC) was significantly lower (p < 0.05) in TW of age group A, B and C than control subjects. Packed cell volume (PCV) was significantly higher (p < 0.05) in TW of age group B while mean corpuscular hemoglobin (MCH) was significantly lower (p < 0.05) in TW of age group D. Within the TW, MCH was significantly lower (p < 0.05) in the age group D as compared to age group A and B. No significant changes were observed in the values of hemoglobin, mean corpuscular volume and mean corpuscular hemoglobin concentration between TW and control individuals. The low values of TEC, PCV and MCH might be a result of chromium exposure in the tannery workers and may act as indicators of chromium toxicity. PMID:21505006

  15. Guide for the use of the regulations on medical surveillance to exposed workers in case of abnormal events (radiological accidents)

    International Nuclear Information System (INIS)

    According to medical surveillance, abnormal events are those extraordinary situations that may imply real or potential damage for a human being or a determined population. This guide refers to abnormal events that may imply, solely, to occupationally-exposed workers and small groups of population eventually related

  16. Cohort Studies on Cancer Mortality Among Workers Exposed Only to Chrysotile Asbestos:a Meta-analysis

    Institute of Scientific and Technical Information of China (English)

    LU LI; TONG-DA SUN; XING ZHANG; RUI-NAN LAI; XIU-YANG LI; XUE-JIN FAN; KENJI MORINAGA

    2004-01-01

    To determine whether there was excessive risk of cancer among workers exposed to chrysotile fiber alone by applying a meta-analysis technique. Methods All data meeting the criteria of cohort studies on cancer mortality among workers exposed only to chrysotile were incorporated into meta-analysis. Pooled standardized mortality ratios (SMRs) and their corresponding 95% confidence intervals (CIs) for main cancer sites were calculated using two approaches of unweighted ratio and random effect model. The heterogeneity and its sources of the results were examined with a Q-statistic and Z-score test. The dose-response effect as reflected in the percentage of all deaths due to mesothelioma served as a proxy measure of chrysotile exposure. Results A cohort of twenty six workers exposed to chrysotile alone was summarized. The significantly elevated meta-SMRs for all deaths (1.27), all cancers (1.28), cancers of respiratory organs (2.51), cancers of lung (2.35) and cancers of stomach (1.24) were observed. The significantly elevated meta-SMRs for lung cancer within occupational strata were observed among textile workers (3.55), asbestos product manufacturers (3.30), miners and millers (2.24), cement product workers (1.22), and for stomach cancer among asbestos product manufacturers (1.49). Meta-SMRs for cancers at other sites were not significant. Meta-SMR for lung cancer showed an increasing trend with an elevated percentage of all deaths from mesothelioma, but no such trend for stomach cancer. Conclusion There are excessive risks of lung cancer and mesothelioma among workers exposed to chrysotile fiber alone, and likely no convincing indication of an etiological association between chrysotile exposure and cancers at other sites.

  17. CHROMOSOMAL ABERRATIONS AND MICRONUCLEI IN LYMPHOCYTES OF MEDICAL RADIATION WORKERS EXPOSED TO LONIZING RADIATION BELOW DOSE LIMIT

    Directory of Open Access Journals (Sweden)

    MOZDARANI H

    2001-01-01

    Full Text Available Introduction: Ionizing radiation induces various kinds of DNA damage in which may lead to chromosomal aberrations (CA. Inspite of growing importance in the risk assessment, the dose yield kinetics of CA and their implications for dose assessment are not well established in exposures to low level radiation. In the present study, cytochalasin-B blocked micronucleus assay and metaphase analysis were used as test system to monitor hospital radiation workers who received chronic low dose ionizing radiation below dose limit. Materials and Methods: Heparinized blood samples were taken from healthy non-smoker radiology and radiotherapy workers occupationally exposed to X and gamma rays and healty population whose duties do not expose them to radiation sources and chemical agents. The whole body dose was measured by film badge. Lymphocytes were cultured in RPMI-1640 supplemented with 15% FBS, and metaphase spread was prepared using standard cytogenetic method. Cytochalasine-B (3 mg/mltreatment was used for binuclei micronuclei assay. 100 mitoses and 1000 binuclei lymphocytes were scored for CA and micronuclei (MN respectively. Results: Results show a high frequency of CA mainly deletions and simple breaks in radiation workers compared to control (p<0.001. Also results show the mean MN/cell was significantly (p<0.001 higher in radiation workers(0.035 when compared to non exposed individuals(0.022. Conclusion: A relatively high frequency of MN and CA formation in lymphocytes of radiation workers compared to non exposed individuals might be due to an accumulation of initial DNA damage in people exposed to chronic doses of radiation leading to detectable genetic damages. These observations might imply that the current occupational exposure levels might be inadequate to prevent an increase in chromosome damage rate.

  18. A multicenter study of biological effects assessment of pharmacy workers occupationally exposed to antineoplastic drugs in Pharmacy Intravenous Admixture Services.

    Science.gov (United States)

    Zhang, Jingjing; Bao, Jianan; Wang, Renying; Geng, Zhou; Chen, Yao; Liu, Xinchun; Xie, Yongzhong; Jiang, Ling; Deng, Yufei; Liu, Gaolin; Xu, Rong; Miao, Liyan

    2016-09-01

    This multi-centered study was designed to evaluate the biological effects of exposure to antineoplastic drugs (ADs) at PIVAS (Pharmacy Intravenous Admixture Service) across ten Chinese hospitals. 8-hydroxy-2-deoxyguanosine (8-OHdG) was used as a biomarker of DNA oxidative damage and lymphocyte apoptosis assays using peripheral lymphocyte cells were used to detect primary DNA damage. The mutagenicity activity was estimated with the Ames fluctuation test. 158 exposed and 143 unexposed workers participated in this study. The urinary 8-OHdG/Cr concentrations of the exposed group was 22.05±17.89ng/mg Cr, which was significantly higher than controls of 17.36±13.50ng/mg Cr (P<0.05). The rate of early lymphocyte apoptosis was slightly increased in exposed group than that of the control group (P=0.087). The mutagenic activity was significantly higher in the exposed group relative to the control group (P<0.05). Moreover, while no statistically significant difference was observed, higher concentrations of 8-OHdG/Cr in urine and an early lymphocyte apoptosis rate were found in exposed group II as compared to exposed group I. In addition, a significant correlation between early lymphocyte apoptosis and exposure time to ADs was also observed (P<0.05). In conclusion, our study identified elevated biomarkers in PIVAS workers exposed to ADs. However whether these findings could lead to increased incidence of genotoxic responses remains to be further investigated. PMID:27179702

  19. Assessment of Some Immune Parameters in Occupationally Exposed Nuclear Power Plants Workers

    Science.gov (United States)

    Panova, Delyana; Djounova, Jana; Rupova, Ivanka; Penkova, Kalina

    2015-01-01

    The purpose of this article is to analyze the results of a 10-year survey of the radiation effects of some immune parameters of occupationally exposed personnel from the Nuclear Power Plant “Kozloduy”, Bulgaria. 438 persons working in NPP with cumulative doses between 0.06 mSv and 766.36mSv and a control group with 65 persons were studied. Flow cytometry measurements of T, B, natural killer (NK) and natural killer T (NKT) cell lymphocyte populations were performed. Data were interpreted with regard to cumulative doses, length of service and age. The average values of the studied parameters of cellular immunity were in the reference range relative to age and for most of the workers were not significantly different from the control values. Low doses of ionizing radiation showed some trends of change in the number of CD3+CD4+ helper-inducer lymphocytes, CD3+ CD8+ and NKT cell counts. The observed changes in some of the studied parameters could be interpreted in terms of adaptation processes at low doses. At doses above 100–200 mSv, compensatory mechanisms might be involved to balance deviations in lymphocyte subsets. The observed variations in some cases could not be attributed only to the radiation exposure because of the impact of a number of other exogenous and endogenous factors on the immune system. PMID:26675014

  20. Flow injection determination of lead and cadmium in hair samples from workers exposed to welding fumes

    International Nuclear Information System (INIS)

    A flow injection procedure involving continuous acid leaching for lead and cadmium determination in hair samples of persons in permanent contact with a polluted workplace environment by flame atomic absorption spectrometry is proposed. Variables such as sonication time, nature and concentration of the acid solution used as leaching solution, leaching temperature, flow-rate of the continuous manifold, leaching solution volume and hair particle size were simultaneously studied by applying a Plackett-Burman design approach. Results showed that nitric acid concentration (leaching solution), leaching temperature and sonication time were statistically significant variables (confidence interval of 95%). These last two variables were finally optimised by using a central composite design. The proposed procedure allowed the determination of cadmium and lead with limits of detection 0.1 and 1.0 μg g-1, respectively. The accuracy of the developed procedure was evaluated by the analysis of a certified reference material (CRM 397, human hair, from the BCR). The proposed method was applied with satisfactory results to the determination of Cd and Pb in human hair samples of workers exposed to welding fumes

  1. [Early recognition of lung cancer in workers occupationally exposed to asbestos].

    Science.gov (United States)

    Hofmann-Preiß, K; Rehbock, B

    2016-09-01

    Despite the fact that working with asbestos and placing it on the market have been banned in Germany since 1993 according to the Ordinance on Hazardous Substances, asbestos-related diseases of the lungs and pleura are still the leading cause of death in occupational diseases. The maximum industrial usage of asbestos was reached in former West Germany in the late 1970s and in former East Germany the late 1980s. Occupational diseases, mainly mesotheliomas and lung cancer emerging now are thus caused by asbestos exposure which occurred 30-40 years earlier. It is known that the combination of smoking and asbestos exposure results in a superadditive increase in the risk to develop lung cancer. No suitable screening methods for early detection of malignant mesothelioma are currently available and the therapeutic options are still very limited; however, the national lung screening trial (NLST) has shown for the first time that by employing low-dose computed tomography (LDCT) in heavy smokers, lung cancer mortality can be significantly reduced. According to current knowledge the resulting survival benefits far outweigh the potential risks involved in the diagnostic work-up of suspicious lesions. These results in association with the recommendations of international medical societies and organizations were pivotal as the German statutory accident insurance (DGUV) decided to provide LDCT as a special occupational medical examination for workers previously exposed to asbestos and with a particularly high risk for developing lung cancer. PMID:27502004

  2. A cytogenetic approach to the effects of low levels of ionizing radiation (IR on the exposed Tunisian hospital workers

    Directory of Open Access Journals (Sweden)

    Sana Bouraoui

    2013-02-01

    Full Text Available Objectives: The aim of this study is to assess chromosomal damage in Tunisian hospital workers occupationally exposed to low levels of ionizing radiation (IR. Materials and Methods: The cytokinesis-block micronucleus (CBMN assay in the peripheral lymphocytes of 67 exposed workers compared to 43 controls matched for gender, age and smoking habits was used. The clastogenic/aneugenic effect of IR was evaluated using the CBMN assay in combination with fluorescence in situ hybridization with human pan-centromeric DNA in all the exposed subjects and controls. Results: The study showed a signifi cant increase of the micronucleus (MN frequency in the lymphocytes of the exposed workers compared to the control group (13.63±4.9‰ vs. 6.52±4.21‰, p < 0.05. The centromere analysis performed in our study showed that MNs in hospital staff were predominantly centromere negative (72% and the mean negative labeled micronucleus (C–MN frequency was signifi cantly higher in the exposed subjects than in the controls (9.04±4.57‰ vs. 1.17±0.77‰. The multivariate regression analysis, taking into account all confounding factors, showed that only the time of exposure to IR had a signifi cant effect on the level of MNs and C–MN. Conclusion: The present study shows that chromosomal damage leading to the formation of micronucleated lymphocytes is more frequent in the hospital workers exposed to IR than in the controls, despite the low levels of exposure. The results of the study confi rm the well-known clastogenic properties of ionizing radiation. In regards to health monitoring, detection of early genotoxic effects may allow for the adoption of preventive biological control measures, such as hygienic improvements in the workplace or reduction of hours of occupational exposure.

  3. Susceptibility to DNA damage in workers occupationally exposed to pesticides, to tannery chemicals and to coal dust during mining

    Directory of Open Access Journals (Sweden)

    Katia Kvitko

    2012-01-01

    Full Text Available Our mutagenesis group has been studying with important economic drivers of our state, such as agriculture, the footwear and leather industry and open-cast coal mining. Working conditions in these sectors have potentially harmful to humans. The aim of these studies is to determine the health risk of workers by biomonitoring subjects exposed to genotoxic agents. The main results of our studies with vineyard farmers we observed a high rate of MN and DNA damage in individuals exposed to pesticides (p < 0.001. In addition, some effects of genetic polymorphisms in the modulation of MN results were observed in this group. Tobacco farmers were also evaluated at different crop times. The results showed a significant increase in the Damage index and frequency in tobacco farmers compared to the non-exposed group, for all crop times. The results for footwear and tannery workers showed a significant increase in the mean ID for the solvent-based adhesive (p < 0.001 group in comparison to the water-based adhesive group and control (p < 0.05. For open-cast coal mine workers, the EBCyt indicated a significant increase in nuclear bud frequency and cytokinetic defects in the exposed group compared to the non-exposed group (p < 0.0001. We were able to associate specific genetic susceptibility with each type of exposure and with the non-use or improper use of personal protection equipment and diet adequacy. These results show how important the continuous education of exposed workers is to minimizing the effect of the occupational exposure and the risk of disease associated with the work.

  4. Study of occupational health impact of atmospheric pollution on exposed workers at an iron and steel complex by using neutron activation analysis of scalp hair

    International Nuclear Information System (INIS)

    The occupational health impact of atmospheric pollution on exposed workers at one iron and steel complex was studied by instrumental neutron activation analysis of workers' hair samples and medical examination. The experimental results indicate that there is a positive correlation between the high inhalation amounts of iron and other trace elements by the exposed workers and the symptom of their high blood pressure and hypoglycemia, which implies that the atmospheric environment polluted by iron and steel industry has an adverse health impact on the exposed workers. The measures to relieve and abate the occupational diseases caused by air-borne particulate matter should be taken. (author)

  5. Sickness absence from 1978 to 1992 of Electricite de France (EDF) workers exposed to ELF-EMF: the substation group

    International Nuclear Information System (INIS)

    Electromagnetic fields are suspected of many health effects, including cancers, immunity and fertility disorders, congenital malformations, suicides and depression.... Although the results of all studies are contradictory and no biological mechanism has been found, populations are concerned about this matter. This study analyzes the absence from work of some EDF employees who are a priori the most professionally exposed to ELF EMF. Absence from work is taken as an health indicator. Although it is not specific, it can be predictive of serious health problems. The specific context of EDF has made it possible to collect and analyze the medical aspect of absence from work, that is rare in France. We were interested with employees working with high voltage (over 90 kV). Three job categories have been selected: live line workers, substation maintenance workers and substation exploitation workers (called in the company the ATEX). The first group concerned the live linemen and the results were exposed previously. It appeared they had more accidents at work, but this was more related to the job of lineman rather than to the EMF exposure. Nevertheless, substation workers have an exposure less intensive but longer than live linemen. We present here the result about the absenteeism of the substation workers, maintenance and exploitation. (author)

  6. Health status of workers of a thermal power station exposed for prolonged periods to arsenic and other elements from fuel.

    Science.gov (United States)

    Buchancová, J; Klimentová, G; Knizková, M; Mesko, D; Gáliková, E; Kubík, J; Fabianová, E; Jakubis, M

    1998-02-01

    The Nováky Power Station (NPS) has been using since 1953 as fuel coal with a high content of As and with a low content of other metals. This involves a constant risk for the workers as well as pollution of the surroundings. The authors described 16 cases of chronic As intoxication in NPS workers after 22.3 +/- 8.4 years of exposure (especially stokers, maintenance workers, boiler cleaners). Among clinical symptoms prevailed sensory and motor polyneuropathy (13 cases), pseudoneurasthenic syndrome (10 cases), toxic encephalopathy (6 cases) and nasal septum perforation (2 cases). After 1989 the intoxications with As did not occur any more due to technical measures and health protection of the workers. The authors present a review of actual results of clinical, haematological and biochemical investigations and tests for metals (AAS methods) in biological materials of workers at risk in NPS (n = 70), exposed on average for 11.9 +/- 0.5 years, of average age 35.91 +/- 1.7 years (mean +/- SE) and compared the results to a matched control group of blood donors not exposed to metals (n = 29). In NPS workers significantly lower Hb values, higher serum creatinine, higher serum beta 2-microglobulin, higher As content in hair as well as higher serum Mn and Pb concentrations compared with the C-group were found. The exposed group had significantly lower serum Se concentrations (0.64 +/- 0.025 mumol/l (mean +/- SE) compared to Se levels of persons from an adjacent district. The authors stress the necessity of individual evaluation of the metal concentrations in relation to clinical findings. With prolonged exposure the situation can become more urgent not only because of chronic poisoning but also because of the cancerogenic effects of these elements on the human organism. PMID:9524739

  7. Beta-carotene reduces oxidative stress, improves glutathione metabolism and modifies antioxidant defense systems in lead-exposed workers

    Energy Technology Data Exchange (ETDEWEB)

    Kasperczyk, Sławomir, E-mail: kaslav@mp.pl [Dept. of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze (Poland); Dobrakowski, Michał [Dept. of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze (Poland); Kasperczyk, Janusz [Dept. of Environmental Medicine and Epidemiology, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze (Poland); Ostałowska, Alina; Zalejska-Fiolka, Jolanta; Birkner, Ewa [Dept. of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze (Poland)

    2014-10-01

    The aim of this study was to determine whether beta-carotene administration reduces oxidative stress and influences antioxidant, mainly glutathione-related, defense systems in workers chronically exposed to lead. The population consisted of two randomly divided groups of healthy male volunteers exposed to lead. Workers in the first group (reference group) were not administered any antioxidants, while workers in the second group (CAR group) were treated orally with 10 mg of beta-carotene once a day for 12 weeks. Biochemical analysis included measuring markers of lead-exposure and oxidative stress in addition to the levels and activities of selected antioxidants. After treatment, levels of malondialdehyde, lipid hydroperoxides and lipofuscin significantly decreased compared with the reference group. However, the level of glutathione significantly increased compared with the baseline. Treatment with beta-carotene also resulted in significantly decreased glutathione peroxidase activity compared with the reference group, while the activities of other glutathione-related enzymes and of superoxide dismutase were not significantly changed. However, the activities of glucose-6-phosphate dehydrogenase and catalase, as well as the level of alpha-tocopherol, were significantly higher after treatment compared with the baseline. Despite controversy over the antioxidant properties of beta-carotene in vivo, our findings showed reduced oxidative stress after beta-carotene supplementation in chronic lead poisoning. - Highlights: • Beta-carotene reduces oxidative stress in lead-exposed workers. • Beta-carotene elevates glutathione level in lead-exposed workers. • Beta-carotene administration could be beneficial in lead poisoning.

  8. Left ventricular diastolic function in workers occupationally exposed to mercury vapour without clinical presentation of cardiac involvement

    International Nuclear Information System (INIS)

    The aim of the study was to evaluate left ventricular diastolic function in workers occupationally exposed to mercury vapour without clinical presentation of cardiac involvement. The studies included 115 workers (92 men and 23 women) occupationally exposed to mercury vapour without clinical presentation of cardiac involvement (mean age: 47.83 ± 8.29). Blood samples were taken to determine blood lipid profile, urine was collected to estimate mercury concentration (Hg-U) and echocardiographic examination was performed to evaluate diastolic function of the left ventricle. In the entire group of workers occupationally exposed to mercury vapour without clinical presentation of cardiac involvement, Spearman correlations analysis demonstrated the following significant linear relationships: between body mass index (BMI) and ratio of maximal early diastolic mitral flow velocity/early diastolic mitral annular velocity (E/E') (r = 0.32, p Hg-U = 1.071, ORBMI = 1.200, ORHDL = 0.896, p < 0.05). Summing up, occupational exposure to mercury vapour may be linked to impaired left ventricular diastolic function in workers without clinical presentation of cardiac involvement. -- Highlights: ► Study aimed at evaluation of LVDD in workers occupationally exposed to Hg. ► There was significant linear relationships between Hg-U and E/E'. ► Independent risk factor of LVDD in study group included higher Hg-U. ► Independent risk factor of LVDD in study group included higher BMI and lower HDL. ► Occupational exposure to Hg may be linked to LVDD.

  9. Beta-carotene reduces oxidative stress, improves glutathione metabolism and modifies antioxidant defense systems in lead-exposed workers

    International Nuclear Information System (INIS)

    The aim of this study was to determine whether beta-carotene administration reduces oxidative stress and influences antioxidant, mainly glutathione-related, defense systems in workers chronically exposed to lead. The population consisted of two randomly divided groups of healthy male volunteers exposed to lead. Workers in the first group (reference group) were not administered any antioxidants, while workers in the second group (CAR group) were treated orally with 10 mg of beta-carotene once a day for 12 weeks. Biochemical analysis included measuring markers of lead-exposure and oxidative stress in addition to the levels and activities of selected antioxidants. After treatment, levels of malondialdehyde, lipid hydroperoxides and lipofuscin significantly decreased compared with the reference group. However, the level of glutathione significantly increased compared with the baseline. Treatment with beta-carotene also resulted in significantly decreased glutathione peroxidase activity compared with the reference group, while the activities of other glutathione-related enzymes and of superoxide dismutase were not significantly changed. However, the activities of glucose-6-phosphate dehydrogenase and catalase, as well as the level of alpha-tocopherol, were significantly higher after treatment compared with the baseline. Despite controversy over the antioxidant properties of beta-carotene in vivo, our findings showed reduced oxidative stress after beta-carotene supplementation in chronic lead poisoning. - Highlights: • Beta-carotene reduces oxidative stress in lead-exposed workers. • Beta-carotene elevates glutathione level in lead-exposed workers. • Beta-carotene administration could be beneficial in lead poisoning

  10. Urinary β2 Microglobulin in Workers Exposed to Arc Welding Fumes

    Directory of Open Access Journals (Sweden)

    Khosro Sadeghniiat-Haghighi

    2011-11-01

    Full Text Available Welding is a process in which two or more metals are attached by the use of heat and, in some cases, pressure. Direct exposure and inhalation of welding fumes causes acute and chronic side effects in humans. Kidney damage is one of these important side effects. β2 microglobulin is an 11.8 kilodalton protein and levels increase in the case of some inflammatory and viral diseases, or kidney malfunction and autoimmune diseases. In this study measurements of β2 microglobulin were used as a criterion for assessing effects on the kidneys of workers exposed to welding fumes. The study population were electric arc welders in an industrial plant in Tehran, Iran. For control we selected workers who did not have any exposure to welding fumes. Both groups were selected on the basis of a questionnaire and the consideration of criteria for inclusion and exclusion. In the end 50 cases and 50 controls were chosen. A urine sample was collected from all participants and urinary pH was set to between 6-8 using NaOH (1M. Sample transportation to the laboratory complied with the related standards. The samples were assessed using the ORG 5BM kit. For quantitative assessment of β2 microglobulin we used the Enzyme-linked Immunosorbent Assay (ELISA method. The ages of the welders ranged from 21 to 48 years (mean=30.5±5.9 yrs and of controls from 23 to 56 years (mean=31.8±5.9 yrs. Mean employment duration was 7.86±5.01years (range 2 to 27 years for welders. Mean β2 microglobulin level was 0.10±0.096 μg/ml in welders and 0.11±0.06 in controls. This difference was not statistically significant (P=0.381. In conclusion we don't find that exposure to electric arc welding fumes cause a significant change in urinary β2 microglobulin compared to the control group.

  11. Neuropsychological Symptoms among Workers Exposed to Toluene and Xylene in Two Paint Manufacturing Factories in Eastern Thailand

    Directory of Open Access Journals (Sweden)

    Anamai Thetkathuek

    2015-01-01

    Full Text Available The study analyzed the exposure factors that may lead to neuropsychological symptoms among 92 workers who were exposed to xylene and toluene and 100 workers who were not exposed to the solvents. The airborne concentration of xylene and toluene was evaluated with personal passive badges. The levels of methyl hippuric acid and hippuric acid in urine were assessed, and interviews were performed to observe the neuropsychological symptoms that may result from exposure to the solvents. The result showed that the average concentration for the exposed group of xylene in the paint company working environment was 2.7 (SD = 2.4 ppm and the average concentration of toluene was 9.5 (SD = 10.4 ppm. The average level of methyl hippuric acid in urine was 78 (SD = 74.7 mg/g creatinine. Factors that affected the neuropsychological symptoms included the following. (1 The impact of age: the risk (adjusted odds ratio for getting psychosomatic symptoms in persons over 40 and exposed to xylene was 9.5 and the aOR of those exposed to toluene was 8.3. (2 The impact of not providing personal protective equipment was found to be sleep disturbance; it was found that the aOR of those exposed to xylene was 3.9, and the aOR of those exposed to toluene was 4.4. In summary, periodic examination of workers by occupational physician is needed for detection of early neuropsychological effects, especially psychosomatic symptoms, and sleep disturbances.

  12. Evaluating the genotoxic effects of workers exposed to lead using micronucleus assay, comet assay and TCR gene mutation test

    International Nuclear Information System (INIS)

    To evaluate the genotoxic effects of lead (Pb) exposure, 25 workers in a workplace producing storage battery were monitored for three genetic end-points using micronucleus (MN) assay, comet assay and TCR gene mutation test. Twenty-five controls were matched with workers according to age, gender and smoking. The air Pb concentration in the workplace was 1.26 mg/m3. All subjects were measured for Pb concentration of blood by atom absorption spectrophotometry. The mean Pb concentration of blood in workers (0.32 mg/l) was significantly higher than that in controls (0.02 mg/l). The results of MN test showed that the mean micronuclei rate (MNR) and mean micronucleated cells rate (MCR) in workers were 9.04 ± 1.51 per mille and 7.76 ± 1.23 per mille , respectively, which were significantly higher than those (2.36 ± 0.42 per mille and 1.92 ± 0.31 per mille ) in controls (P -4 and 1.74 ± 0.17 x 10-4, respectively, there was no significant difference between workers and controls (P > 0.05). The results of our study indicated that the genetic damage was detectable in 25 workers occupationally exposed to lead

  13. Lung scintigraphy evaluation in workers exposed to abrasive dusts; Avaliacao cintilografica pulmonar em trabalhadores de industria de abrasivos

    Energy Technology Data Exchange (ETDEWEB)

    Terra Filho, Mario

    1995-12-31

    The production process of abrasives use aluminium, or silicon carbide a synthetic material with a hardness only slightly less than that of a diamond. It is popularly known as carborundum since it was first manufactured as an abrasive in 1891, produced by the fusion of high grade silica and petroleum coke with sawdust. For many years silicon carbide was thought not to give rise to pulmonary lesions. Recently several researchers suggested the existence of a carborundum pneumoconiosis. The aim of this study was to evaluate the role of the pulmonary clearance of {sup 99m} Technetium chelated to diethylene-triamine penta-acetate ({sup 99m} Tc DTPA), and {sup 67} Gallium lung scanning in workers exposed to abrasive dusts. Thirty seven subjects, 13 smokers and 24 nonsmokers and ex smokers were studied. In 32 (86,48%) {sup 67} Gallium lung scanning was positive including 13 (40,62%) retired workers. We conclude that non smoking workers of abrasives plants have a pulmonary alveolar epithelial permeability disturbance similar as observed in smoking workers and smoking controls. Most workers, ex-workers of these industries and in patients with carborundum pneumoconiosis there is an evidence of pulmonary inflammation measured with abnormal {sup 67} Gallium lung scan. (author) 101 refs., 2 figs., 11 tabs.

  14. Chest HRCT signs predict deaths in long-term follow-up among asbestos exposed workers

    International Nuclear Information System (INIS)

    Highlights: • Much lung and pleural pathology is found in chest CT studies. • HRCT signs were screened and subsequent mortality followed up. • Several signs were related to all-cause and disease specific deaths. • The HRCT classification system used was able to predict mortality. • Secondary preventive strategies should be developed for patients with such signs. - Abstract: Objectives: To study associations between chest HRCT signs and subsequent deaths in long-term follow-up. Methods: Lung and pleural signs of 633 asbestos exposed workers (age 45–86, mean 65) screened with HRCT were recorded by using the International Classification of Occupational and Environmental Respiratory Diseases (ICOERD) system, which contains detailed instructions for use and reference images. Subsequent mortality was checked from the national register. Cox regression adjusted for covariates (age, sex, BMI, asbestos exposure, pack-years) was used to explore the relations between HRCT signs and all-cause deaths, cardiovascular and benign respiratory deaths, and deaths from neoplasms – all according to the ICD-10 diagnostic system. Results: The follow-up totalled 5271.9 person-years (mean 8.3 y/person, range .04–10.3). 119 deaths were reported. Irregular/linear opacities, honeycombing, emphysema, large opacities, visceral pleural abnormalities and bronchial wall thickening were all significantly related to all-cause deaths. Most of these signs were associated also with deaths from neoplasms and benign respiratory disease. Deaths from cardiovascular disease were predicted by emphysema and visceral pleural abnormalities. Conclusions: Several HRCT signs predicted deaths. Careful attention should be paid on subjects with radiological signs predictive of deaths and new secondary preventive strategies developed. This calls for further focused studies among different populations

  15. Blood biomarkers in metal scrap workers accidentally exposed to ionizing radiation: a case study.

    Science.gov (United States)

    Gupta, M L; Srivastava, N N; Dutta, S; Shukla, S K; Dutta, A; Verma, S; Devi, M

    2013-12-01

    The detrimental effect of nuclear accidents due to localized or whole body radiation exposure results in severe cellular damage. The current study was carried out to evaluate radiation-mediated variability in blood components of metal scrap workers exposed accidently to cobalt-60 source. Blood samples collected initially from five hospitalized patients, coded P1-P5, were processed for total leukocyte counts (TLC), platelet (PLT) counts, haemoglobin, estimation of DNA double strand breaks by measuring phosphorylated form of H2AX (γ-H2AX) and chromosomal aberrations (dicentrics). Blood cells count (TLC), in all the patients except P2, was found decreased. Dicentrics increased in all the five patients. γ-H2AX was found significantly elevated in patients P2 and P4. After 3 days, 21 subjects working in close vicinity of accident site were evaluated for the above-mentioned markers to confirm their possibility of radiation exposure; however, all the parameters in these subjects were found within normal limits. Blood from patients P1-P5 was collected again after 11 days. Studies revealed exorbitant increase in γ-H2AX in lymphocytes and monocytes of patients P1, P4 and P5. TLC and PLT count in these patients had fallen further. Dicentrics declined with time in all the five patients. Based on the studied blood biomarkers, we conclude that the five subjects showed signs of radiation exposure. Measurement on radiation dose could not be performed in the current study; however, the generated data particularly on dicentrics provide ample evidence of radiation exposure.

  16. Chest HRCT signs predict deaths in long-term follow-up among asbestos exposed workers

    Energy Technology Data Exchange (ETDEWEB)

    Vehmas, Tapio, E-mail: tapio.vehmas@ttl.fi [Health and Work Ability, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FI-00250 Helsinki (Finland); Oksa, Panu, E-mail: panu.oksa@ttl.fi [Health and Work Ability, Finnish Institute of Occupational Health, Uimalankatu 1, FI-33101 Tampere (Finland)

    2014-10-15

    Highlights: • Much lung and pleural pathology is found in chest CT studies. • HRCT signs were screened and subsequent mortality followed up. • Several signs were related to all-cause and disease specific deaths. • The HRCT classification system used was able to predict mortality. • Secondary preventive strategies should be developed for patients with such signs. - Abstract: Objectives: To study associations between chest HRCT signs and subsequent deaths in long-term follow-up. Methods: Lung and pleural signs of 633 asbestos exposed workers (age 45–86, mean 65) screened with HRCT were recorded by using the International Classification of Occupational and Environmental Respiratory Diseases (ICOERD) system, which contains detailed instructions for use and reference images. Subsequent mortality was checked from the national register. Cox regression adjusted for covariates (age, sex, BMI, asbestos exposure, pack-years) was used to explore the relations between HRCT signs and all-cause deaths, cardiovascular and benign respiratory deaths, and deaths from neoplasms – all according to the ICD-10 diagnostic system. Results: The follow-up totalled 5271.9 person-years (mean 8.3 y/person, range .04–10.3). 119 deaths were reported. Irregular/linear opacities, honeycombing, emphysema, large opacities, visceral pleural abnormalities and bronchial wall thickening were all significantly related to all-cause deaths. Most of these signs were associated also with deaths from neoplasms and benign respiratory disease. Deaths from cardiovascular disease were predicted by emphysema and visceral pleural abnormalities. Conclusions: Several HRCT signs predicted deaths. Careful attention should be paid on subjects with radiological signs predictive of deaths and new secondary preventive strategies developed. This calls for further focused studies among different populations.

  17. Proposal and application of methodology for monitoring workers occupationally exposed to Thorium-232 and its decay products

    International Nuclear Information System (INIS)

    Thorium-232 is the parent of one of the naturally occurring decay series and is widely spread on the earth's crust, being also present in higher concentrations at some deposits located mainly in Brazil and India. The occupational exposure to this radionuclide may occur in several steps of the thorium cycle. In Brazil, there is a large number of workers that should be monitored because they manipulate directly or indirectly different kinds of ores, raw materials and products containing significant amounts of thorium in its composition. In this study, the techniques developed specifically for the in vivo and in vitro monitoring of these workers are presented together with the application of these techniques to a group of selected workers classified as occupationally exposed. It is also presented the methodology by which the results obtained with these measurements are interpreted with the objective of identifying the main pathways of incorporation and reducing the internal doses to values as low as reasonably achievable. (author)

  18. Respiratory function and bronchial responsiveness among industrial workers exposed to different classes of occupational agents: a study from Algeria

    Directory of Open Access Journals (Sweden)

    Hoet Peter H

    2007-10-01

    Full Text Available Abstract Occupational exposures play a role in the onset of several chronic airway diseases. We investigated, in a cross-sectional study, lung function parameters and bronchial hyper-responsiveness to histamine in workers exposed to different airborne compounds. The study group totalled 546 male subjects of whom 114 were exposed to welding fumes, 106 to solvents, 107 to mineral dust, 97 to organic dust and 123 without known exposure to airway irritants. A questionnaire was administered and spirometry and bronchial responsiveness to histamine were assessed by one observer, in the morning before work to prevent effects of acute exposure. The mean (SD age of the participants was 39.3 (7.8 years, with a mean duration of employment of 13.8 (6.6 years. Both before and after adjustment for smoking status, forced expiratory volume in 1 second (FEV1, expressed as % predicted was lower in welders -4.0% (95% confidence interval [CI], -6.3 to -1.8; p = 0.01 and workers exposed to solvents -5.6% (CI: -7.9 to -3.3; p = 0.0009 than in control subjects. Furthermore, solvent workers had an odds ratio of 3.43 (95% CI: 1.09–11.6; p = 0.037 for bronchial hyperresponsiveness compared with the reference group. The higher prevalence of bronchial hyperresponsiveness in solvent workers adds to the growing body of evidence of adverse respiratory effects of occupational solvent exposure. These results point to the necessity of preventive measures in solvent workers to avoid these adverse respiratory effects.

  19. Determination of eye lens doses and identification of risk groups among radiation exposed workers. An Austrian pilot study

    International Nuclear Information System (INIS)

    On European level, in 2014 the dose limit for the lens of the eye of radiation exposed workers has been reduced from 150 to 20 mSv per year (2013/59/Euratom). Data about eye lens exposition measured under realistic operational conditions of Austrian radiation exposed workers is sparse and there is no information to verify, if all professional groups identified to be at risk for elevated eye doses will remain below the new annual dose limit. Therefore, financed by the Austrian Workers Compensation Board, AUVA, a pilot study has been initiated to answer this question. Based on published information professional groups of radiation exposed workers and operational tasks with an enhanced risk of elevated eye lens doses have been identified. By dosimetric measurements with volunteers (forehead dose meters and parallel measurements with whole-body TL-dose meters above and under the lead apron) realistic lens doses will be estimated during selected radiation exposed tasks. Comparison of yielded doses will show whether a TLD outside the apron could serve as an alternative to forehead dose meters dedicated to measure eye lens doses. Measurements with leaded protective eyewear based on IEC61331 yield results for lead equivalent in good agreement with manufacturers' information. Results for eye lens doses determined by use of a RANDO head phantom and a standardized phantom simulating a body in a typical exposition situation for interventional radiologists show that wearing of leaded goggles allows for a 90% dose reduction. Under such conditions the eye lens dose is dominated by backscatter and stray radiation from the operator's head and patient body. This has to be considered for the evaluation of protective effectiveness for leaded eye wear.

  20. Biomonitoring of diesel exhaust-exposed workers. DNA and hemoglobin adducts and urinary 1-hydroxypyrene as markers of exposure

    DEFF Research Database (Denmark)

    Nielsen, Per Sabro; Andreassen, Åshild; Farmer, Peter B.;

    1996-01-01

    the 32P-postlabelling method with butanol and P1 enrichment procedures. Hydroxyethylvaline (HOEtVal) adducts in hemoglobin were measured by gas chromatography-mass spectrometry (GC-MS) and 1-hydroxypyrene (HPU) in urine determined using HPLC analysis. The exposed workers had significantly higher levels....... The study indicated that skin absorption of polycyclic aromatic hydrocarbons (PAH) might be an important factor to consider when studying PAH exposure from air pollution sources....

  1. Respiratory, allergy and eye problems in bagasse-exposed sugar cane workers in Costa Rica

    NARCIS (Netherlands)

    Gascon, M.; Kromhout, H.; Heederik, D.; Eduard, W.; van Wendel de Joode, B.N.

    2012-01-01

    AIMS: To evaluate bagasse (sugar cane fibres) and microbiological exposure among sugar cane refinery workers in Costa Rica and its relationships with respiratory, allergy and eye problems. METHODS: Ventilatory lung function and total serum IgE were measured in 104 sugar cane workers in five departme

  2. Risk assessment of silicosis and lung cancer among construction workers exposed to respirable quartz

    NARCIS (Netherlands)

    Tjoe Nij, E.; Heederik, D.

    2005-01-01

    Objectives: The aim of this study was to assess the magnitude of the silicosis and cancer risk among construction workers. Methods: In 1998, 1335 of 4173 invited construction workers with expected high cumulative exposure to quartz were studied for early signs of silicosis. In 2002 the study was rep

  3. Comparative analysis of audiometric and impedancemetric findings in workers exposed to the effects of various duration industrial noise

    Directory of Open Access Journals (Sweden)

    Živić Ljubica

    2010-01-01

    Full Text Available Background/Aim. Industrial noise is produced in workshops due to factory machinery and tools used in technological processes. It has detrimental effect to primarily the organ of the sense of hearing, thus damaging hearing in oversensitive subjects. The aim of the study was to perform a detailed analysis of audiometric and, especially, impedancemetric parameters in workers exposed to the effects of industrial noise of various duration, as well as to determine similarities and differences in workers with differences in sensitivity to damaging effects of noise. Methods. The study included a homogenous group of 173 industrial workers involved in the same department of a huge workshop named 'Kovačica' exposed to noise level above a threshold intensity, and divided into three groups: the group I of 116 workers (232 ears exposed to noise for 8 h in the workshop 'Kovačica', the group II of 41 workers (82 ears exposed to noise only half of the working time, and the group III of 16 workers (32 ears exposed to the same conditions and having the normal hearing sense. The group III served as a control group. Prior to the study any workers went through a thorough anamnesis and complete ORL examination, and then they were submitted to audiometric testing. The study included only the workers with no hearing damage due to diseases, injuries nor other detrimental factors in order to be sure that the hearing findings had been caused by industrial noise. Results. The results obtained by audiometric testing showed that 90.75% of the workers had hearing damage of various degrees, while 9.25 % of the workers had regular hearing although had been exposed to the same conditions. More severe hearing damage was revealed in the workers of the group I. Tympanometricly, in most ears of the group I workers (65.52% a compliance value was found to be more than 0.9 cm3, while in the majority of those of the group II (59.75% a compliance value was in the range from 0.5 to 0

  4. Ferruginous bodies and pulmonary fibrosis in dead low to moderately exposed asbestos cement workers: histological examination.

    OpenAIRE

    Johansson, L. G.; Albin, M P; Jakobsson, K. M.; Welinder, H E; Ranstam, P J; Attewell, R G

    1987-01-01

    Histological slides from the lungs of 89 dead asbestos cement workers have been examined with respect to ferruginous bodies and fibrosis. The results have been compared with individually matched controls with no known exposure to asbestos, and related to asbestos exposure, expressed as duration of exposure and cumulative asbestos dose, and smoking habits. The asbestos cement workers studied had been employed for on average 15 years, with a mean cumulative dose of 26 fibre-years per ml (f-y/ml...

  5. Increase in DNA damage in lymphocytes and micronucleus frequency in buccal cells in silica-exposed workers

    Directory of Open Access Journals (Sweden)

    Ajanta Halder

    2012-01-01

    Full Text Available The alkaline single cell gel electrophoresis (comet assay was applied to study the genotoxic properties of silica in human peripheral blood lymphocytes (PBL. The study was designed to evaluate the DNA damage of lymphocytes and the end points like micronuclei from buccal smears in a group of 45 workers, occupationally exposed to silica, from small mines and stone quarries. The results were compared to 20 sex and age matched normal individuals. There was a statistically significant difference in the damage levels between the exposed group and the control groups. The types of damages (type I -type 1V were used to measure the DNA damage. The numbers of micronuclei were higher in the silica-exposed population. The present study suggests that the silica exposure can induce lymphocyte DNA damage and produces significant variation of micronuclei in buccal smear.

  6. Management and processing of dosimetric data of workers exposed to ionizing radiation

    International Nuclear Information System (INIS)

    The Madagascar - INSTN Radiation protection and Dosimetry Department use the reader HARSHAW TLD 6600 for workers doses reading. Although the performance of this device, manual works is required to store and to maintain the dosimetric data after reading and to note the TLDs sent to the establishments. To avoid these manual works, this present work proposes computer programs written in Python and using SQLite software. One of the programs in python retrieves dose values after reading and transfers directly these doses in the workers database. The use of SQLite software provides a way for the dosimetric data management and the TLDs movement monitoring. The other program assesses estimation of the dose received by worker through a trend curve for workers dosimetric monitoring. The calculated differences of this curve over the curve connecting all points are less than 20%, acceptable limit in radiation protection for TLDs. This present work presents then significances for the personnel occupying individual monitoring of ionizing radiation workers and for these workers too.

  7. Evaluation of The Relationship Between Mercury Exposure and Oxidative DNA Lesions in Workers Occupationally Expose to Mercury

    International Nuclear Information System (INIS)

    Evaluation of antioxidant status by measuring the activities of super oxidase dismutase and glutathione peroxidase and the concentrations of total reduced glutathione and protein-bound thiols in the serum, also, measuring urinary 8-hydroxy-2- deoxyguanosine (8-OHdG); which is used as bio marker of oxidative DNA damage in the mercury exposed persons was the objective of this study. The study was carried out on 40 workers exposed to mercury on the job in collaboration with National Institute of Occupational Safety and Health. Samples were collected in December 2008 from workers at fluorescent lamps and dry batteries factories. Urinary 8-hydroxy-2- deoxyguanosine (8-OHdG) was measured used as bio marker of oxidative DNA damage in the mercury exposed persons. The antioxidant status was assessed by measuring the activities of super oxidase dismutase and glutathione peroxidase and the concentrations of total reduced glutathione and protein-bound thiols were also evaluated in the serum. In this study, urinary 8-OHdG which is a metabolite of oxidized DNA was used to evaluate whether mercury exposure led to oxidative damage to DNA. The activities of serum GSH-Px and superoxide dismutase (SOD) and the concentrations of GSH and total protein-boundthiol were also investigated to clarify the relation-ship between body mercury status and oxidative stress. Forty subjects were chosen to participate in this study from workers exposed to mercury on the job. Ten healthy, subjects, matching in age, sex and socio-economic status were chosen as a control group

  8. A retrospective cohort study of cause-specific mortality and incidence of hematopoietic malignancies in Chinese benzene-exposed workers.

    Science.gov (United States)

    Linet, Martha S; Yin, Song-Nian; Gilbert, Ethel S; Dores, Graça M; Hayes, Richard B; Vermeulen, Roel; Tian, Hao-Yuan; Lan, Qing; Portengen, Lutzen; Ji, Bu-Tian; Li, Gui-Lan; Rothman, Nathaniel

    2015-11-01

    Benzene exposure has been causally linked with acute myeloid leukemia (AML), but inconsistently associated with other hematopoietic, lymphoproliferative and related disorders (HLD) or solid tumors in humans. Many neoplasms have been described in experimental animals exposed to benzene. We used Poisson regression to estimate adjusted relative risks (RR) and the likelihood ratio statistic to derive confidence intervals for cause-specific mortality and HLD incidence in 73,789 benzene-exposed compared with 34,504 unexposed workers in a retrospective cohort study in 12 cities in China. Follow-up and outcome assessment was based on factory, medical and other records. Benzene-exposed workers experienced increased risks for all-cause mortality (RR = 1.1, 95% CI = 1.1, 1.2) due to excesses of all neoplasms (RR = 1.3, 95% CI = 1.2, 1.4), respiratory diseases (RR = 1.7, 95% CI = 1.2, 2.3) and diseases of blood forming organs (RR = ∞, 95% CI = 3.4, ∞). Lung cancer mortality was significantly elevated (RR = 1.5, 95% CI = 1.2, 1.9) with similar RRs for males and females, based on three-fold more cases than in our previous follow-up. Significantly elevated incidence of all myeloid disorders reflected excesses of myelodysplastic syndrome/acute myeloid leukemia (RR = 2.7, 95% CI = 1.2, 6.6) and chronic myeloid leukemia (RR = 2.5, 95% CI = 0.8, 11), and increases of all lymphoid disorders included excesses of non-Hodgkin lymphoma (RR = 3.9, 95%CI = 1.5, 13) and all lymphoid leukemia (RR = 5.4, 95%CI = 1.0, 99). The 28-year follow-up of Chinese benzene-exposed workers demonstrated increased risks of a broad range of myeloid and lymphoid neoplasms, lung cancer, and respiratory diseases and suggested possible associations with other malignant and non-malignant disorders.

  9. Comparison of hematological alterations and markers of B-cell activation in workers exposed to benzene, formaldehyde and trichloroethylene.

    Science.gov (United States)

    Bassig, Bryan A; Zhang, Luoping; Vermeulen, Roel; Tang, Xiaojiang; Li, Guilan; Hu, Wei; Guo, Weihong; Purdue, Mark P; Yin, Songnian; Rappaport, Stephen M; Shen, Min; Ji, Zhiying; Qiu, Chuangyi; Ge, Yichen; Hosgood, H Dean; Reiss, Boris; Wu, Banghua; Xie, Yuxuan; Li, Laiyu; Yue, Fei; Freeman, Laura E Beane; Blair, Aaron; Hayes, Richard B; Huang, Hanlin; Smith, Martyn T; Rothman, Nathaniel; Lan, Qing

    2016-07-01

    Benzene, formaldehyde (FA) and trichloroethylene (TCE) are ubiquitous chemicals in workplaces and the general environment. Benzene is an established myeloid leukemogen and probable lymphomagen. FA is classified as a myeloid leukemogen but has not been associated with non-Hodgkin lymphoma (NHL), whereas TCE has been associated with NHL but not myeloid leukemia. Epidemiologic associations between FA and myeloid leukemia, and between benzene, TCE and NHL are, however, still debated. Previously, we showed that these chemicals are associated with hematotoxicity in cross-sectional studies of factory workers in China, which included extensive personal monitoring and biological sample collection. Here, we compare and contrast patterns of hematotoxicity, monosomy 7 in myeloid progenitor cells (MPCs), and B-cell activation biomarkers across these studies to further evaluate possible mechanisms of action and consistency of effects with observed hematologic cancer risks. Workers exposed to benzene or FA, but not TCE, showed declines in cell types derived from MPCs, including granulocytes and platelets. Alterations in lymphoid cell types, including B cells and CD4+ T cells, and B-cell activation markers were apparent in workers exposed to benzene or TCE. Given that alterations in myeloid and lymphoid cell types are associated with hematological malignancies, our data provide biologic insight into the epidemiological evidence linking benzene and FA exposure with myeloid leukemia risk, and TCE and benzene exposure with NHL risk. PMID:27207665

  10. Dose estimation by ESR on tooth enamel from two workers exposed to radiation due to the JCO accident

    International Nuclear Information System (INIS)

    Electron spin resonance (ESR) dosimetry is useful to estimate the external dose for the general population as well as for occupational workers in a nuclear emergency. Three teeth were extracted from two exposed workers (A and B) related to the JCO criticality accident. Tooth enamel was carefully separated from other tooth parts and subjected to ESR dosimetry. Doses equivalent to the γ-ray dose of 60Co were estimated as follows: for worker A, the buccal and lingual sides of the eighth tooth in the upper right side, 11.8±3.6 and 12.0±3.6 Gy, respectively; for worker B, the buccal and lingual sides of the fourth tooth in the upper right side and the fifth tooth in the upper left side, 11.3±3.4 and 10.8±3.3 Gy, 11.7±3.5 and 11.4±3.4 Gy, respectively. The estimated doses were found to be similar and not dependent on the tooth positions, whether the buccal or lingual sides in each tooth. (author)

  11. The number of workers exposed to ionizing radiation decreased slightly in 2013 in France

    International Nuclear Information System (INIS)

    The number of people monitored for occupational exposure to ionizing radiation reached 352.082 in 2013 in France, it means a slight decrease of 0.7% with respect to 2012 figures. The number of monitored people decreased by 3% in nuclear industry while it increased by 1% in the health sector. The average external radiation dose reached 0.19 mSv, 13.892 workers received a dose greater than 1 mSv and 1894 workers received a dose over 6 mSv. An external annual dose over 20 mSv was recorded for 9 workers. The workers from the non-nuclear industry and the nuclear industry received the highest external doses on the average, respectively 1.62 mSv and 1.27 mSv while the health and research sectors have the lowest mean individual doses: less than 0.6 mSv. Concerning internal exposure, the number of cases of internal contamination remains low: 18 workers received a radiation dose ranging between 1 mSv and 9 mSv in 2013. (A.C.)

  12. Dental erosion in workers exposed to sulfuric acid in lead storage battery manufacturing facility.

    Science.gov (United States)

    Suyama, Yuji; Takaku, Satoru; Okawa, Yoshikazu; Matsukubo, Takashi

    2010-01-01

    Dental erosion, and specifically its symptoms, has long been studied in Japan as an occupational dental disease. However, in recent years, few studies have investigated the development of this disease or labor hygiene management aimed at its prevention. As a result, interest in dental erosion is comparatively low, even among dental professionals. Our investigation at a lead storage battery factory in 1991 found that the work environmental sulfuric acid density was above the tolerable range (1.0mg/m(3)) and that longterm workers had dental erosion. Therefore, workers handling sulfuric acid were given an oral examination and rates of dental erosion by tooth type, rates of erosion by number of working years and rates of erosion by sulfuric acid density in the work environment investigated. Where dental erosion was diagnosed, degree of erosion was identified according to a diagnostic criterion. No development of dental erosion was detected in the maxillary teeth, and erosion was concentrated in the anterior mandibular teeth. Its prevalence was as high as 20%. Rates of dental erosion rose precipitously after 10 working years. The percentages of workers with dental erosion were 42.9% for 10-14 years, 57.1% for 15-19 years and 66.7% for over 20 years with 22.5% for total number of workers. The percentages of workers with dental erosion rose in proportion to work environmental sulfuric acid density: 17.9% at 0.5-1.0, 25.0% at 1.0-4.0 and 50.0% at 4.0-8.0mg/m(3). This suggests that it is necessary to evaluate not only years of exposure to sulfuric acid but also sulfuric acid density in the air in factory workers.

  13. Carcinogenesis and Inflammatory Effects of Plutonium-Nitrate Retention in an Exposed Nuclear Worker and Beagle Dogs.

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, Christopher E. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Wang, Xihai [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Robinson, Robert J. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Brooks, Antone L. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Lovaglio, Jamie A. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Patton, Kristin M. [Battelle Toxicology Northwest, Richland, WA (United States); McComish, Stacey [United States Transuranium and Uranium Registries, Washington State University, College of Pharmacy, Richland, WA (United States); Tolmachev, Sergei Y. [United States Transuranium and Uranium Registries, Washington State University, College of Pharmacy, Richland, WA (United States); Morgan, William F. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

    2014-01-01

    The genetic and inflammatory response pathways elicited following plutonium exposure in archival lung tissue of an occupationally exposed human and experimentally exposed beagle dogs were investigated. These pathways include: tissue injury, apoptosis and gene expression modifications related to carcinogenesis and inflammation. In order to determine which pathways are involved, multiple lung samples from a plutonium exposed worker (Case 0269), a human control (Case 0385), and plutonium exposed beagle dogs were examined using histological staining and immunohistochemistry. Examinations were performed to identify target tissues at risk of radiation-induced fibrosis, inflammation, and carcinogenesis. Case 0269 showed interstitial fibrosis in peripheral and subpleural regions of the lung, but no pulmonary tumors. In contrast, the dogs with similar and higher doses showed pulmonary tumors primarily in brochiolo-alveolar, peripheral and subpleural alveolar regions. The TUNEL assay showed slight elevation of apoptosis in tracheal mucosa, tumor cells, and nuclear debris was present in the inflammatory regions of alveoli and lymph nodes of both the human and the dogs. The expression of apoptosis and a number of chemokine/cytokine genes was slightly but not significantly elevated in protein or gene levels compared to that of the control samples. In the beagles, mucous production was increased in the airway epithelial goblet cells and glands of trachea, and a number of chemokine/cytokine genes showed positive immunoreactivity. This analysis of archival tissue from an accidentally exposed worker and in a large animal model provides valuable information on the effects of long-term retention of plutonium in the respiratory tract and the histological evaluation study may impact mechanistic studies of radiation carcinogenesis.

  14. Carcinogenesis and Inflammatory Effects of Plutonium-Nitrate Retention in an Exposed Nuclear Worker and Beagle Dogs

    International Nuclear Information System (INIS)

    The genetic and inflammatory response pathways elicited following plutonium exposure in archival lung tissue of an occupationally exposed human and experimentally exposed beagle dogs were investigated. These pathways include: tissue injury, apoptosis and gene expression modifications related to carcinogenesis and inflammation. In order to determine which pathways are involved, multiple lung samples from a plutonium exposed worker (Case 0269), a human control (Case 0385), and plutonium exposed beagle dogs were examined using histological staining and immunohistochemistry. Examinations were performed to identify target tissues at risk of radiation-induced fibrosis, inflammation, and carcinogenesis. Case 0269 showed interstitial fibrosis in peripheral and subpleural regions of the lung, but no pulmonary tumors. In contrast, the dogs with similar and higher doses showed pulmonary tumors primarily in brochiolo-alveolar, peripheral and subpleural alveolar regions. The TUNEL assay showed slight elevation of apoptosis in tracheal mucosa, tumor cells, and nuclear debris was present in the inflammatory regions of alveoli and lymph nodes of both the human and the dogs. The expression of apoptosis and a number of chemokine/cytokine genes was slightly but not significantly elevated in protein or gene levels compared to that of the control samples. In the beagles, mucous production was increased in the airway epithelial goblet cells and glands of trachea, and a number of chemokine/cytokine genes showed positive immunoreactivity. This analysis of archival tissue from an accidentally exposed worker and in a large animal model provides valuable information on the effects of long-term retention of plutonium in the respiratory tract and the histological evaluation study may impact mechanistic studies of radiation carcinogenesis

  15. Comparison of genetic damage in Brazilian footwear-workers exposed to solvent-based or water-based adhesive.

    Science.gov (United States)

    Heuser, Vanina Dahlström; de Andrade, Vanessa Moraes; da Silva, Juliana; Erdtmann, Bernardo

    2005-05-01

    Research has shown that workers employed in footwear manufacture are at increased risk of some cancers, the strongest evidence being for nasal cancer and leukemia. Footwear-workers are routinely exposed to complex mixtures of solvents in degreasers, cleaners, primers, and adhesives used in the production process as toluene, n-hexane, acetone, and possibly dust particles, additives in shoe materials and degradation products of materials. The recognition of the potential health-hazards of solvent-based adhesives (SBAs) has lead to the development of adhesives with no organic solvents, the water-based adhesives (WBA). We investigated footwear-workers (all males) exposed to SBA (n=29) (for 3.98+/-4.13 years), and WBA (n=16), which had spent the six months previous to the study employed in an experimental section which used only water-based adhesives, although they had previously worked in sections which used solvent-based adhesives (for 5.80+/-4.03 years); 25 healthy subjects were used as controls. The Comet assay and the micronucleus test were used as endpoints, while the traditional parameters for assessing exposure to toluene in organic mixtures by measuring the concentration of urinary hippuric acid were also assessed. Our results showed a significantly lower mean concentration of hippuric acid in the control group than found in the SBA (Pdamage index for the SBA (Pcomparison to the WBA group and control (Pwater-based adhesives are clearly a better option for safeguarding the health of footwear-workers, even with possibility of isocyanate presence, while the positive results observed in SBA group might be explained by chloroprene presence in the adhesive.

  16. Increased levels of urinary biomarkers of lipid peroxidation products among workers occupationally exposed to diesel engine exhaust.

    Science.gov (United States)

    Bin, Ping; Shen, Meili; Li, Haibin; Sun, Xin; Niu, Yong; Meng, Tao; Yu, Tao; Zhang, Xiao; Dai, Yufei; Gao, Weimin; Gu, Guizhen; Yu, Shanfa; Zheng, Yuxin

    2016-08-01

    Diesel engine exhaust (DEE) was found to induce lipid peroxidation (LPO) in animal exposure studies. LPO is a class of oxidative stress and can be reflected by detecting the levels of its production, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), and etheno-DNA adducts including 1,N(6)-etheno-2'-deoxyadenosine (ɛdA) and 3,N(4)-etheno-2'-deoxycytidine (ɛdC). However, the impact of DEE exposure on LPO has not been explored in humans. In this study, we evaluated urinary MDA, 4-HNE, ɛdA, and ɛdC levels as biomarkers of LPO among 108 workers with exclusive exposure to DEE and 109 non-DEE-exposed workers. Results showed that increased levels of urinary MDA and ɛdA were observed in subjects occupationally exposed to DEE before and after age, body mass index (BMI), smoking status, and alcohol use were adjusted (all p < 0.001). There was a statistically significant relationship between the internal exposure dose (urinary ΣOH-PAHs) and MDA, 4-HNE, and ɛdA (all p < 0.001). Furthermore, significant increased relations between urinary etheno-DNA adduct and MDA, 4-HNE were observed (all p < 0.05). The findings of this study suggested that the level of LPO products (MDA and ɛdA) was increased in DEE-exposed workers, and urinary MDA and ɛdA might be feasible biomarkers for DEE exposure. LPO induced DNA damage might be involved and further motivated the genomic instability could be one of the pathogeneses of cancer induced by DEE-exposure. However, additional investigations should be performed to understand these observations. PMID:27087348

  17. Parallel assessment of male reproductive function in workers and wild rats exposed to pesticides in banana plantations in Guadeloupe

    Directory of Open Access Journals (Sweden)

    Huc-Terki Farida

    2008-07-01

    Full Text Available Abstract Background There is increasing evidence that reproductive abnormalities are increasing in frequency in both human population and among wild fauna. This increase is probably related to exposure to toxic contaminants in the environment. The use of sentinel species to raise alarms relating to human reproductive health has been strongly recommended. However, no simultaneous studies at the same site have been carried out in recent decades to evaluate the utility of wild animals for monitoring human reproductive disorders. We carried out a joint study in Guadeloupe assessing the reproductive function of workers exposed to pesticides in banana plantations and of male wild rats living in these plantations. Methods A cross-sectional study was performed to assess semen quality and reproductive hormones in banana workers and in men working in non-agricultural sectors. These reproductive parameters were also assessed in wild rats captured in the plantations and were compared with those in rats from areas not directly polluted by humans. Results No significant difference in sperm characteristics and/or hormones was found between workers exposed and not exposed to pesticide. By contrast, rats captured in the banana plantations had lower testosterone levels and gonadosomatic indices than control rats. Conclusion Wild rats seem to be more sensitive than humans to the effects of pesticide exposure on reproductive health. We conclude that the concept of sentinel species must be carefully validated as the actual nature of exposure may varies between human and wild species as well as the vulnerable time period of exposure and various ecological factors.

  18. Retrospective diagnosis of Q fever in a country abattoir by the use of specific IgM globulin estimations

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, A.M.; Hunt, J.G.

    1981-10-03

    Twenty-two cases of pyrexial illness which occurred amongst workers in a country abattoir were investigated retrospectively for Q fever, brucellosis, and leptospirosis. In 18, the illness was shown to be Q fever. No diagnoses were established for the other four. The demonstration of circulating Q-fever-specific IgM globulin was instrumental in establishing the diagnosis in many of the cases.

  19. AIRWAY HYPERRESPONSIVENESS AND THE PREVALENCE OF WORK-RELATED SYMPTOMS IN WORKERS EXPOSED TO IRRITANTS

    NARCIS (Netherlands)

    KREMER, AM; PAL, TM; BOLEIJ, JSM; SCHOUTEN, JP; RIJCKEN, B

    1994-01-01

    The association between exposure to airway irritants and the presence of work-related symptoms and whether this association was modified by airway hyper-responsiveness, smoking, and allergy by history was studied in 668 workers of synthetic fiber plants. A Dutch version of the British Medical Resear

  20. Neurobehavioural changes and persistence of complaints in workers exposed to styrene in a polyester boat building plant: influence of exposure characteristics and microsomal epoxide hydrolase phenotype

    OpenAIRE

    Viaene, M; Pauwels, W.; Veulemans, H.; Roels, H.; Masschelein, R

    2001-01-01

    OBJECTIVES—To investigate neurobehavioural effects and the persistence of complaints in workers exposed to styrene relative to exposure characteristics and the enzyme microsomal epoxide hydrolase (mEH) activity.
METHODS—A cross sectional study was performed in a retrospective cohort of workers of a polyester boat building plant 3 years after the main activity shut down in 1989. Workers still currently exposed to a much lower concentration of styrene in air than before (n=27) and formerly expo...

  1. Sister chromatid exchange analysis in lymphocytes of workers exposed to hexavalent chromium.

    OpenAIRE

    Nagaya, T.; Ishikawa, N.; Hata, H.

    1989-01-01

    To investigate the usefulness of sister chromatid exchange (SCE) analysis in lymphocytes as an indicator for mutagenic effects after in vivo exposure to hexavalent chromium (Cr), SCE frequency was analysed in lymphocytes of 44 Cr platers occupationally exposed to hexavalent Cr and 47 controls. Although urinary Cr analysis confirmed that the Cr platers were exposed to Cr, no effects of the exposure on SCE frequency were found. Smokers, both Cr platers and controls, had a significantly higher S...

  2. Acute liver injury in two workers exposed to chloroform in cleanrooms: a case report.

    Science.gov (United States)

    Kang, Young Joong; Ahn, Jungho; Hwang, Yang-In

    2014-01-01

    We report 2 cases of hepatotoxicity in cleanroom workers due to high retained chloroform air concentrations. The women, aged 34 and 41 years, who had been working in a medical endoscopic device manufacturer as cleanroom workers for approximately 40-45 days suffered severe liver damage. Two measured time-weighted averages of the chloroform concentration in the air in the cleanroom were 82.74 and 64.24 ppm, which are more than 6 times the legal occupational exposure limit in Korea. Only 7% of the cleanroom air was newly introduced from outside. The clinical courses of these cases and workplace inspection, led us to conclude that both cases of hepatotoxicity were caused by chloroform exposure.

  3. Ischemic heart disease risk factors in lead exposed workers: research study

    OpenAIRE

    Ghiasvand, Masoumeh; Aghakhani, kamran; Salimi, Ahmad; Kumar, Ranjit

    2013-01-01

    Background Review of other epidemiological studies reveal inconsistent results of relationships between high blood lead level and risk of hypertension, hyperlipidemia and hyperglycemia. In this study we wanted to find if there is a relationship between blood lead level and these ischemic heart disease risk factors. Methods This cross-sectional study was conducted in a battery recycling plant, and 497 male workers with the mean age of 41.7 (±6.50) years were recruited from all over the plant (...

  4. [The effect of the length of exposure and smoking on respiratory function in workers exposed to asbestos-cement dust].

    Science.gov (United States)

    Milardović-Sunjara, B; Kanceljak-Macan, B; Dujmov, I

    1991-01-01

    Respiratory function tests were performed in 110 workers who were occupationally exposed to asbestos-cement dust in the period from 7 to 34 years. Due to the results obtained, the following groups of patients were analysed according to years of asbestos-cement exposure and the habit of cigarette smoking. The analysis of the years of exposure to asbestos-cement dust revealed that the workers with the exposure longer than 16 years had significantly lower FVC and FEV1 (P less than 0.001) than the workers whose exposure was less than 16 years. In view of increasing age this deterioration proved to be significantly higher than it had been expected. Of all the subjects included in this study 7% of them were found to have a partial respiratory insufficiency. The phenomenon could not be explained either by the length of exposure or by the habit of cigarette smoking. In the smoking subjects with the longest exposure, a markedly lower SaHbO2 was found as compared to the smokers with the shortest exposure (P less than 0.05). PMID:1766985

  5. A study on oxidative stress and antioxidant status of agricultural workers exposed to organophosphorus insecticides during spraying

    Directory of Open Access Journals (Sweden)

    Rastogi S

    2009-01-01

    Full Text Available Oxidative stress status and Acetylcholinesterase (AChE activity were studied in blood samples obtained from 61 agricultural workers engaged in spraying organophosphorus (OP insecticides in the mango plantation, with a minimum work history of one year, in the age range of 12-55 years. Controls were age-matched, unexposed workers, who never had any exposure to OP pesticides. They were evaluated for oxidative stress markers MDA (end product of lipid peroxidation, reduced glutathione (GSH, and Acetylcholinesterase (AChE and butyrylcholinesterase (BChE levels in blood. The results showed a marked inhibition of the AChE and BChE activities in the sprayers as compared to the controls. The malondialdehyde(MDA, the last product of lipid peroxidation was found to be increased significantly in sprayers(p< 0.05, while depletion in the concentration of antioxidant glutathione(GSH was also observed in the sprayers but the difference was statistically not significant. It was concluded on the basis of biochemical analysis that pesticides sprayers are exposed to more oxidative stress as evidenced by the changes in antioxidant status. The measurement of the AChE and BChE activities in agricultural workers who spray OPs could be a good biomonitoring factor and is recommended to be performed on a regular basis.

  6. Evaluating levels and health risk of heavy metals in exposed workers from surgical instrument manufacturing industries of Sialkot, Pakistan.

    Science.gov (United States)

    Junaid, Muhammad; Hashmi, Muhammad Zaffar; Malik, Riffat Naseem

    2016-09-01

    The study aimed to monitor heavy metal (chromium, Cr; cadmium, Cd; nickel, Ni; copper, Cu; lead, Pb; iron, Fe; manganese, Mn; and zinc, Zn) footprints in biological matrices (urine, whole blood, saliva, and hair), as well as in indoor industrial dust samples, and their toxic effects on oxidative stress and health risks in exposed workers. Overall, blood, urine, and saliva samples exhibited significantly higher concentrations of toxic metals in exposed workers (Cr; blood 16.30 μg/L, urine 58.15 μg/L, saliva 5.28 μg/L) than the control samples (Cr; blood 5.48 μg/L, urine 4.47 μg/L, saliva 2.46 μg/L). Indoor industrial dust samples also reported to have elevated heavy metal concentrations, as an example, Cr quantified with concentration of 299 mg/kg of dust, i.e., more than twice the level of Cr in household dust (136 mg/kg). Superoxide dismutase (SOD) level presented significant positive correlation (p ≤ 0.01) with Cr, Zn, and Cd (Cr > Zn > Cd) which is an indication of heavy metal's associated raised oxidative stress in exposed workers. Elevated average daily intake (ADI) of heavy metals resulted in cumulative hazard quotient (HQ) range of 2.97-18.88 in workers of different surgical units; this is an alarming situation of health risk implications. Principal component analysis-multiple linear regression (PCA-MLR)-based pie charts represent that polishing and cutting sections exhibited highest metal inputs to the biological and environmental matrices than other sources. Heavy metal concentrations in biological matrices and dust samples showed a significant positive correlation between Cr in dust, urine, and saliva samples. Current study will help to generate comprehensive base line data of heavy metal status in biomatrices and dust from scientifically ignored industrial sector. Our findings can play vital role for health departments and industrial environmental management system (EMS) authorities in policy making and implementation.

  7. Cohort studies on cancer mortality among nuclear workers exposed to low-dose ionizing radiation: a meta-analysis

    International Nuclear Information System (INIS)

    To provide direct estimates of risk of cancer after protracted low doses of ionising radiation and to strengthen the scientific basis of radiation protection standards for low-dose ionising radiation exposure. Published papers referring to 20 low-dose ionising radiation-exposed cohorts among nuclear industry workers with Standardized Mortality Ratios (SMR) were recta-analyzed in fixed and random effect models. The significantly deficient Meta-SMRs for all deaths (0.73; 95% CI: 0.66-0.80), all cancers (0.83; 95% CI: 0.77- 0.91), lung cancer (0.93; 95% CI: 0.90-0.95), non-Hodgkin lymphoma (0.88; 95% CI: 0.78- 0.99), esophagus cancer (0.83; 95% CI:0.76-0.91), colorectal cancer (0.88; 95% CI: 0.83-0.94), stomach cancer (0.81; 95% CI: 0.76-0.86) were observed. The Meta-SMRs for leukemia, multiple myeloma, Hodgkin's disease were found to be no significant difference with normal populations. There was no excessive risk of cancers among nuclear workers exposed to low-doses and low-dose rates ionizing radiation. (authors)

  8. Peak expiratory flow rate in asymptomatic male workers exposed to chemical fumes, in various industries of Hyderabad

    Directory of Open Access Journals (Sweden)

    Padaki Samata K, Dambal Amrut , Kokiwar Prashant

    2014-11-01

    Full Text Available Context: The prevalence of occupational health hazards and mortality has been reported to be unusually high among people of India. Although developed countries are very much careful about the health in occupations it is quite neglected in the developing countries like India. Aims: To record PEFR in asymptomatic male workers exposed to chemical fumes for more than 2 years and compare the results with age matched unexposed, healthy male controls. Methods and Material: This was a comparative study between 50 asymptomatic male workers exposed to chemical fumes for more than 2 years in various industries located at Jeedimetla Industrial Area and 50 unexposed healthy male individuals from general population. The sampling was done by simple random sampling (lottery method. The data was collected in the Research Laboratory of Physiology. Anthropometry like weight, height, was measured and the PEFR test was performed in the standing position by taking a deep inspiration and then blowing out as hard and as quickly as possible with their nose closed. Data was analyzed by using SPSS package and was expressed in terms of mean ± SD. Results: It was observed that mean PEFR was statistically highly significant in cases (p = 0.0001, and PEFR decreased with increase in duration of exposure. Conclusions: Thus, it can be concluded that apparently healthy individuals may also have abnormal PEFR findings. Hence, a regular check on these parameters will help them in reducing the chances of its manifestation at a future date.

  9. Plasma cytokine concentrations in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD

    Directory of Open Access Journals (Sweden)

    Fatemeh eSaberi Hosnijeh

    2012-04-01

    Full Text Available ObjectivesFew epidemiological studies have studied the effect of 2,3,7,8-tetrachlorodibenzo-p dioxin (TCDD on blood cytokine levels. In this study we investigated changes in plasma levels of a large panel of cytokines, chemokines and growth factors among workers from a Dutch historical cohort occupationally exposed to chlorophenoxy herbicides and contaminants including TCDD.MethodsEighty-five workers who had been exposed to either high (n=47 or low (n=38 TCDD levels more than 30 years before serum collection were included in the current investigation. Plasma level of 16 cytokines, 10 chemokines and 6 growth factors were measured. Current plasma levels of TCDD (TCDDCurrent were determined by high resolution gas chromatography/isotope dilution high resolution mass spectrometry. TCDD blood levels at the time of last exposure (TCDDmax were estimated using a one-compartment first order kinetic model. ResultsBlood levels of most analytes had a negative association with current and estimated past maximum TCDD levels. These decreases reached formal statistical significance for fractalkine, transforming growth factor alpha (TGF-α and fibroblast growth factor 2 (FGF2 with increasing TCDD levels.ConclusionsOur study showed a general reduction in most analyte levels with the strongest effects for fractalkine, FGF2 and TGF-α. These findings suggest that TCDD exposure could suppress the immune system and that chemokine and growth factor-dependent cellular pathway changes by TCDD may play role in TCDD toxicity and associated health effects.

  10. Low Dose-Rate Effects on Chromosomal Aberrations in Workers Occupationally Exposed to Ionising Radiation

    International Nuclear Information System (INIS)

    Full text: Occupational exposure to ionising radiation can be assessed by chromosomal aberrations detected in peripheral blood lymphocytes. Blood samples were collected from 47 occupationally exposed individuals (X-ray diagnostic machines and industrial gamma defectoscopy). The chromosomal aberrations were analysed from at least 500 metaphases per person and their frequencies were compared with those obtained from 110 control individuals. It has been noticed the higher frequency of chromosomal aberrations in the exposed group related to the control. The increase was analysed according to the age groups (31-40, 41-50, and 51-60), sex and duration of employment. The higher frequency of dicentrics was not directly correlated with the age or duration of employment in the exposed group. The acentric fragments were encountered with much higher frequency in the exposed group. The chromosomal aberrations induced by low dose-rate in occupationally exposed people revealed the degree of individual sensitivity and the severity of the initial damage depending on the biological-pathological conditions. (author)

  11. Gender and respiratory findings in workers occupationally exposed to organic aerosols: A meta analysis of 12 cross-sectional studies

    Directory of Open Access Journals (Sweden)

    Mustajbegovic Jadranka

    2009-01-01

    Full Text Available Abstract Background Gender related differences in respiratory disease have been documented. The aim of this study was to investigate gender related differences in respiratory findings by occupation. We analyzed data from 12 of our previously published studies. Methods Three thousand and eleven (3011 workers employed in "organic dust" industries (1379 female and 1632 male were studied. A control group of 806 workers not exposed to any kind of dust were also investigated (male = 419, female = 387. Acute and chronic respiratory symptoms and lung function were measured. The weighted average method and the Mantel-Haentszel method were used to calculate the odds ratios of symptoms. Hedge's unbiased estimations were used to measure lung function differences between men and women. Results There were high prevalences of acute and chronic respiratory symptoms in all the "dusty" studied groups compared to controls. Significantly less chronic cough, chronic phlegm as well as chronic bronchitis were found among women than among men after the adjustments for smoking, age and duration of employment. Upper respiratory tract symptoms by contrast were more frequent in women than in men in these groups. Significant gender related lung function differences occurred in the textile industry but not in the food processing industry or among farmers. Conclusion The results of this study suggest that in industries processing organic compounds there are gender differences in respiratory symptoms and lung function in exposed workers. Whether these findings represent true physiologic gender differences, gender specific workplace exposures or other undefined gender variables not defined in this study cannot be determined. These data do not suggest that special limitations for women are warranted for respiratory health reasons in these industries, but the issue of upper respiratory irritation and disease warrants further study.

  12. Metabolic Polymorphisms and Clinical Findings Related to Benzene Poisoning Detected in Exposed Brazilian Gas-Station Workers

    Directory of Open Access Journals (Sweden)

    Simone Mitri

    2015-07-01

    Full Text Available Benzene is a ubiquitous environmental pollutant and an important industrial chemical present in both gasoline and motor vehicle emissions. Occupational human exposure to benzene occurs in the petrochemical and petroleum refining industries as well as in gas-station workers, where it can lead to benzene poisoning (BP, but the mechanisms of BP are not completely understood. In Brazil, a significant number of gas-station service workers are employed. The aim of the present study was to evaluate alterations related to BP and metabolic polymorphisms in gas-station service workers exposed to benzene in the city of Rio de Janeiro, Brazil. Occupational exposure was based on clinical findings related to BP, and metabolic polymorphisms in 114 Brazilian gas-station attendants. These workers were divided into No Clinical Findings (NCF and Clinical Findings (CF groups. Neutrophil and Mean Corpuscular Volume (MCV showed a significant difference between the two study groups, and neutrophil has the greatest impact on the alterations suggestive of BP. The clinical findings revealed higher frequencies of symptoms in the CF group, although not all members presented statistical significance. The frequencies of alleles related to risk were higher in the CF group for GSTM1, GSTT1, CYP2E1 7632T > A, but lower for NQO1 and CYP2E1 1053C > T genotypes. Moreover, an association was found between GSTM1 null and alterations related to BP, but we did not observe any effects of other polymorphisms. Variations in benzene metabolizing genes may modify benzene toxicity and should be taken into consideration during risk assessment evaluations.

  13. Toxoplasma gondii infection in workers occupationally exposed to unwashed raw fruits and vegetables: a case control seroprevalence study

    Directory of Open Access Journals (Sweden)

    Alvarado-Esquivel Cosme

    2011-12-01

    Full Text Available Abstract Background Through a case control seroprevalence study, we sought to determine the association of Toxoplasma gondii infection with occupational exposure to unwashed raw fruits and vegetables. Methods Subjects, numbering 200, who worked growing or selling fruits and vegetables, and 400 control subjects matched by age, gender, and residence were examined by enzyme immunoassays for the presence of anti-Toxoplasma IgG and IgM antibodies. Socio-demographic, clinical, and behavioral characteristics from the study subjects were obtained. Results Of the 200 fruit and vegetable workers, 15 (7.5% of whom, and 31 (7.8% of the 400 controls were positive for anti-Toxoplasma IgG antibodies (P = 0.96. Anti-Toxoplasma IgM antibodies were found in 2 (1% of the fruit workers and in 11 (2.8% of the control subjects (P = 0.23. Seroprevalence of Toxoplasma antibodies increased with age (P = 0.0004. In addition, seropositivity to Toxoplasma was associated with ill status (P = 0.04, chronic tonsillitis (P = 0.03, and reflex impairment (P = 0.03. Multivariate analysis showed that Toxoplasma infection was associated with consumption of raw meat (OR = 5.77; 95% CI: 1.15-28.79; P = 0.03, unwashed raw fruits (OR = 2.50; 95% CI: 1.11-5.63; P = 0.02, and living in a house with soil floors (OR = 3.10; 95% CI: 1.22-7.88; P = 0.01, whereas Toxoplasma infection was negatively associated with traveling abroad (OR = 0.28; 95% CI: 0.12-0.67; P = 0.005. Conclusions This is the first report of seroprevalence and contributing factors for Toxoplasma infection in workers occupationally exposed to unwashed raw fruits and vegetables, and the results may help in the design of optimal preventive measures against Toxoplasma infection especially in female workers at reproductive age.

  14. Nocturnal 6-hydroxymelatonin sulfate excretion in female workers exposed to magnetic fields

    Energy Technology Data Exchange (ETDEWEB)

    Juutilainen, J (Kuopio, University of); Stevens, Richard G.(BATTELLE (PACIFIC NW LAB)); Anderson, Larry E.(BATTELLE (PACIFIC NW LAB)); Hansen, Norman H.(WAVEID); Kilpelainen, M (Kuopio, University of); Kumlin, T (Kuopio, University of); Laitinen, J T.(Kuopio, University of); Sobell, Eugene (Southern California, Univ Of); Wilson, Bary W.(BATTELLE (PACIFIC NW LAB))

    2000-03-15

    The objective of this study was to determine whether daytime occupational exposure to extremely low frequency magnetic fields (MFs) suppresses nocturnal melatonin production. Sixty female volunteers were recruited. Thirty-nine worked in a garment factory, and 21 office workers served as a reference group. Exposure assessment was based on the type of sewing machine used and MF measurements around each type of machine. Eye-level MF flux density was used to classify the operators to higher (> 1 microT) and lower (0.3-1 microT) exposure categories. A third group of factory workers had diverse MF exposures from other sources. The reference group had average exposure of about 0.15 microT. Urine samples were collected on Friday and Monday for three consecutive weeks. Melatonin production was assessed as urinary 6-hydroxymelatonin sulfate (6-OHMS) excretion. The ratio of Friday morning/Monday morning 6-OHMS was used to test the hypothesis that melatonin production is suppressed after 4 days of occupational MF exposure with significant recovery during the weekend. Possible chronic suppression of melatonin production was evaluated by studying exposure-related differences in the Friday values by multivariate regression analysis. The Monday/Friday ratios were close to 1.0, suggesting that there is no increase in melatonin production over the weekend. The average 6-OHMS excretion on Friday was lower among the factory workers than in the reference group, but no monotonous dose-response was observed. Multivariate regression analysis identified MF exposure, smoking, and age as significant explanatory variables associated with decreased 6-OHMS excretion.

  15. Proportionate mortality study of workers in the garment industry exposed to formaldehyde

    Energy Technology Data Exchange (ETDEWEB)

    Stayner, L.; Smith, A.B.; Reeve, G.; Blade, L.; Elliott, L.; Keenlyside, R.; Halperin, W.

    1985-01-01

    In order to evaluate the human carcinogenicity of formaldehyde, the authors conducted a proportionate mortality study of garment workers engaged in the production of shirts from formaldehyde-treated cloth. This study included three plants, and was based upon 256 deaths identified from a death-benefit insurance fund. No deaths due to nasal cancer were observed, and the mortality from respiratory cancer (11 cases, PMR = 95) was slightly less than expected. Statistically significant (p less than . 05) elevations in proportionate mortality were observed for malignant neoplasms of the ''buccal cavity'' (three cases, PMR = 750), for ''biliary passages and liver'' (four cases, PMR = 313) and for ''other lymphatic and hematopoietic sites'' (four cases, PMR = 400). A proportionate cancer mortality (PCMR) analysis also was conducted, and cancer of the ''buccal cavity'' (three cases, PCMR = 682), and other ''lymphatic and hematopoietic sites'' (four cases, PCMR = 342) were still significantly elevated. The observed excesses in cancer mortality were primarily experienced by white females, who made up the major portion of the workforce, and workers with more than 10 years of latency and duration of exposure, a criterion for inclusion for most workers in the study group. The neoplasms observed were not equally distributed among the three facilities included in the study. Because of the small number of deaths involved and the lack of consistency with other studies, the authors believe that these findings should be viewed cautiously, pending the outcome of more definitive studies.

  16. The Effect of the Abattoir on Beef Carcass Classification Results

    Directory of Open Access Journals (Sweden)

    Maja Prevolnik

    2011-10-01

    Full Text Available The aim of the present study was to test a possible way of monitoring cattle carcass classification using a statistical approach. For that purpose the analysis of covariance (ANCOVA by SAS was used with the fixed effect of the abattoir, carcass weight (as a covariate and their interaction. The analysis was based on the relationship between carcass weight and conformation or fatness grades. We tested if the regression lines of individual abattoirs differ from the average. The analysis comprised data for young bulls of Simmental breed slaughtered in Slovenia in the period from 2007 to 2010 (52,624 records. Results showed that in many abattoirs the assessment of conformation and fatness deviates significantly from the average, i.e. regression lines for several abattoirs differ significantly from the average (population line. Differences were more important for the conformation than fatness. The statistical process control using the analysis of covariance can be used for additional monitoring of cattle carcass classification.

  17. The Effect of the Abattoir on Beef Carcass Classification Results

    Directory of Open Access Journals (Sweden)

    Maja Prevolnik

    2011-09-01

    Full Text Available The aim of the present study was to test a possible way of monitoring cattle carcass classification using a statistical approach. For that purpose the analysis of covariance (ANCOVA by SAS was used with the fixed effect of the abattoir, carcass weight (as a covariate and their interaction. The analysis was based on the relationship between carcass weight and conformation or fatness grades. We tested if the regression lines of individual abattoirs differ from the average. The analysis comprised data for young bulls of Simmental breed slaughtered in Slovenia in the period from 2007 to 2010 (52,624 records. Results showed that in many abattoirs the assessment of conformation and fatness deviates significantly from the average, i.e. regression lines for several abattoirs differ significantly from the average (population line. Differences were more important for the conformation than fatness. The statistical process control using the analysis of covariance can be used for additional monitoring of cattle carcass classification.

  18. Telomere Length in Aged Mayak PA Nuclear Workers Chronically Exposed to Internal Alpha and External Gamma Radiation.

    Science.gov (United States)

    Scherthan, Harry; Sotnik, Natalia; Peper, Michel; Schrock, Gerrit; Azizova, Tamara; Abend, Michael

    2016-06-01

    Telomeres consist of GC-rich DNA repeats and the "shelterin" protein complex that together protect chromosome ends from fusion and degradation. Telomeres shorten with age due to incomplete end replication and upon exposure to environmental and intrinsic stressors. Exposure to ionizing radiation is known to modulate telomere length. However, the response of telomere length in humans chronically exposed to radiation is poorly understood. Here, we studied relative telomere length (RTL) by IQ-FISH to leukocyte nuclei in a group of 100 workers from the plutonium production facility at the Mayak Production Association (PA) who were chronically exposed to alpha-emitting ((239)Pu) radiation and/or gamma (photon) radiation, and 51 local residents serving as controls, with a similar mean age of about 80 years. We applied generalized linear statistical models adjusted for age at biosampling and the second exposure type on a linear scale and observed an age-dependent telomere length reduction. In those individuals with the lowest exposure, a significant reduction of about 20% RTL was observed, both for external gamma radiation (≤1 Gy) and internal alpha radiation (≤0.05-0.1 Gy to the red bone marrow). In highly exposed individuals (>0.1 Gy alpha, 1-1.5 Gy gamma), the RTL was similar to control. Stratification by gender revealed a significant (∼30%) telomere reduction in low-dose-exposed males, which was absent in females. While the gender differences in RTL may reflect different working conditions, lifestyle and/or telomere biology, absence of a dose response in the highly exposed individuals may reflect selection against cells with short telomeres or induction of telomere-protective effects. Our observations suggest that chronic systemic exposure to radiation leads to variable dose-dependent effects on telomere length. PMID:27340887

  19. Telomere Length in Aged Mayak PA Nuclear Workers Chronically Exposed to Internal Alpha and External Gamma Radiation.

    Science.gov (United States)

    Scherthan, Harry; Sotnik, Natalia; Peper, Michel; Schrock, Gerrit; Azizova, Tamara; Abend, Michael

    2016-06-01

    Telomeres consist of GC-rich DNA repeats and the "shelterin" protein complex that together protect chromosome ends from fusion and degradation. Telomeres shorten with age due to incomplete end replication and upon exposure to environmental and intrinsic stressors. Exposure to ionizing radiation is known to modulate telomere length. However, the response of telomere length in humans chronically exposed to radiation is poorly understood. Here, we studied relative telomere length (RTL) by IQ-FISH to leukocyte nuclei in a group of 100 workers from the plutonium production facility at the Mayak Production Association (PA) who were chronically exposed to alpha-emitting ((239)Pu) radiation and/or gamma (photon) radiation, and 51 local residents serving as controls, with a similar mean age of about 80 years. We applied generalized linear statistical models adjusted for age at biosampling and the second exposure type on a linear scale and observed an age-dependent telomere length reduction. In those individuals with the lowest exposure, a significant reduction of about 20% RTL was observed, both for external gamma radiation (≤1 Gy) and internal alpha radiation (≤0.05-0.1 Gy to the red bone marrow). In highly exposed individuals (>0.1 Gy alpha, 1-1.5 Gy gamma), the RTL was similar to control. Stratification by gender revealed a significant (∼30%) telomere reduction in low-dose-exposed males, which was absent in females. While the gender differences in RTL may reflect different working conditions, lifestyle and/or telomere biology, absence of a dose response in the highly exposed individuals may reflect selection against cells with short telomeres or induction of telomere-protective effects. Our observations suggest that chronic systemic exposure to radiation leads to variable dose-dependent effects on telomere length.

  20. Prevalence of bovine Cysticercosis of Slaughtered Cattle in Meshkinshahr Abattoir

    OpenAIRE

    Garedaghi, Y.; A. P.R. Saber; M. S. Khosroshahi

    2011-01-01

    Problem statement: The occurrence of the larvae of Taenia saginata (T. saginata) in cattle musculature causes T. saginata cysticercosis or bovine cysticercosis while the adult worms in human small intestines cause taeniasis. Approach: In this study, the prevalence of Taenia saginata cysticercosis in cattle slaughtered for meat in Meshkinshahr Abattoir, Iran between September 2010 and August 2011 was reported. Results: The examination of various organs of 500 cattle in Meshkinshahr Abattoir sh...

  1. Alterations in serum immunoglobulin levels in workers occupationally exposed to trichloroethylene

    OpenAIRE

    Zhang, Luoping; Bassig, Bryan A.; Mora, Joseph L.; Vermeulen, Roel; Ge, Yichen; Curry, John D.; Hu, Wei; Shen, Min; Qiu, Chuangyi; Ji, Zhiying; Reiss, Boris; McHale, Cliona M.; Liu, Songwang; Guo, Weihong; Purdue, Mark P.

    2012-01-01

    Trichloroethylene (TCE) has been associated with a variety of immunotoxic effects and may be associated with an increased risk of non-Hodgkin lymphoma (NHL). Altered serum immunoglobulin (Ig) levels have been reported in NHL patients and in animals exposed to TCE. Recently, we reported that occupational exposure to TCE is associated with immunosuppressive effects and immune dysfunction, including suppression of B-cell counts and activation, even at relatively low levels. We hypothesized that ...

  2. Assessment of DNA integrity (COMET assay) in sperm cells of boron-exposed workers.

    Science.gov (United States)

    Duydu, Yalçin; Başaran, Nurşen; Ustündağ, Aylin; Aydin, Sevtap; Undeğer, Ulkü; Ataman, Osman Yavuz; Aydos, Kaan; Düker, Yalçin; Ickstadt, Katja; Waltrup, Britta Schulze; Golka, Klaus; Bolt, Hermann M

    2012-01-01

    An extension of a male reproductive study conducted in a boric acid/borate production zone at Bandırma, Turkey, is presented. The relation between DNA-strand breaks (COMET assay, neutral and alkaline version) in sperm cells and previously described sperm quality parameters was investigated in boron-exposed males. A correlation between blood boron levels and mean DNA-strand breaks in sperm was weak, and DNA-strand breaks in sperm were statistically not different between control and exposed groups. Therefore, increasing boron exposures had no additional contribution in addition to already pre-existing DNA-strand breaks in the sperm cells. Weak but statistically significant correlations between DNA-strand breaks and motility/morphology parameters of sperm samples were observed in the neutral version of the COMET assay, while correlations between the same variables were statistically not significant in the alkaline version. A likely reason for these negative results, even in highly exposed humans, is that experimental exposures that had led to reproductive toxicity in animals were significantly higher than any boron exposures, which may be reached under realistic human conditions.

  3. DNA damage in female workers exposed to pesticides in banana plantations at Limon, Costa Rica

    International Nuclear Information System (INIS)

    Pesticide use in Costa Rica is very high and all year round. A high percentage of what is sprayed remains in the environment and in the living organisms around. This situation brings contamination and health problems to people in contact with them. The onset of adverse effects may be in the short or long term, and symptoms vary widely, from headaches to cancer. Much research in the area has been devoted to acute or chronic effects, and not until recently to the genotoxic effect of pesticides. This study evaluated the genotoxic effect of pesticide used in banana packing activities, using the comet assay (single cell electrophoresis) as the biological marker in lymphocytes. This was a cases-control double blind study of 30 exposed women from 15 banana farms and 28 women not occupationally exposed to pesticides from the same geographic area. Results show damage to single straded DNA after working from 5 to 15 years (R2=0.12). In Costa Rica we do not have an historical record of the kind of pesticides used in banana farms, the period of time and for how long were they used. This prevented further analysis concerning dose, frequency of exposure and use of new or old kind of pesticides in the farms in relation to DNA damage. The comet assay is of value in the genetic monitoring of pesticide exposed populations. (Author)

  4. Analysis of whole-body doses received by occupationally exposed workers in Ireland (1996-1999)

    International Nuclear Information System (INIS)

    The work described in this paper is based on the results of routine whole-body measurements carried out by the Radiological Protection Institute of Ireland Dosimetry Service from 1996 to 1999. Data on the occupational radiation exposures of monitored personnel are examined and have been found to follow the skewed distribution reported by UNSCEAR. The annual average effective dose for each major work practice over the 4 years is given and compared with the UNSCEAR reference value of 1.1 mSv per year for all occupations. Evidence suggests that improvements in procedures and the use of better equipment have resulted in a reduction in the number of workers receiving measurable doses. (author)

  5. Symptoms, airway physiology and histology of workers exposed to medium-density fiber board.

    Science.gov (United States)

    Holmström, M; Rosén, G; Wilhelmsson, B

    1991-12-01

    Medium-density fiber (MDF) board was recently introduced in the furniture industry. In this pilot study health complaints, physiology, and histology of the upper airways were evaluated for two groups of workers, one handling MDF board for at least one-third of their work week (MDF group) and another handling traditional fiber board. Civil servants served as a reference group. The frequency of health complaints concerning the airways was higher, the sense of smell was poorer, and the frequency of nasal obstruction measured with rhinomanometry was higher for the MDF group, while mucociliary activity was lower in the group handling traditional board. In both groups forced vital capacity was low when compared with expected values. Histological specimens from the middle turbinate of the nose showed, in a few cases, nasal epithelial dysplasia in the traditional board group, but histological changes in terms of scoring did not differ significantly between the groups. PMID:1788535

  6. Health care of people at work. Workers exposed to lead. I. Inorganic lead

    Energy Technology Data Exchange (ETDEWEB)

    Waldron, H.A.

    1978-01-01

    The risks associated with exposure to inorganic lead and the means by which these risks can be minimized are outlined. Lead is used to make a variety of metal products, the grids and oxides in storage batteries, pigments, chemicals, and also for lead plating. In the United States about 70% of the total lead consumption is related to transportation. Uptake of inorganic lead is by ingestion and inhalation. About 90% of the total body burden of lead is contained within the skeletal tissues. Lead is excreted in the kidney, in sweat, and in milk. Toxic effects are directed against the blood, the nervous system, and the kidney. Symptoms of lead poisoning are abdominal pain, constipation, vomiting, asthenia, paresthesia, psychological symptoms, and diarrhea. Physical and biological monitoring can serve to protect workers. Diagnosis of lead poisoning is not easy. Treatment involves removal from exposure and/or treatment with a chelating agent.

  7. Behavioural and physiological reactions of cattle in a commercial abattoir: relationships with organisational aspects of the abattoir and animal characteristics.

    Science.gov (United States)

    Bourguet, Cécile; Deiss, Véronique; Tannugi, Carole Cohen; Terlouw, E M Claudia

    2011-05-01

    Behavioural, physiological and metabolic reactions of cattle to handling and slaughter procedures were evaluated in a commercial abattoir, from arrival until slaughter. Different genders or breeds were not subjected to the same procedures due to abattoir equipment or organisational aspects of the abattoir. Reactions to similar slaughter procedures varied according to animal characteristics and could have consequences for subsequent handling procedures. Factors that appeared to cause handling problems and vocalisation were excessive pressure during restraint, and distractions in the corridor such as noise, darkness, seeing people and activity. Post-mortem muscle metabolism depended on slaughter procedures. Following stunning or halal slaughter, some animals showed head rising movements despite the abolition of the corneal reflex, suggesting that head rising is not always indicative of consciousness. Overall, this study presents concrete data on how different types of cattle may react to slaughter procedures with a direct interest for the abattoir itself but also for scientific purposes. PMID:21236588

  8. Assessment of Some Immune Parameters in Occupationally Exposed Nuclear Power Plants Workers

    OpenAIRE

    Gyuleva, Ilona; Panova, Delyana; Djounova, Jana; Rupova, Ivanka; Penkova, Kalina

    2015-01-01

    The purpose of this article is to analyze the results of a 10-year survey of the radiation effects of some immune parameters of occupationally exposed personnel from the Nuclear Power Plant “Kozloduy”, Bulgaria. 438 persons working in NPP with cumulative doses between 0.06 mSv and 766.36mSv and a control group with 65 persons were studied. Flow cytometry measurements of T, B, natural killer (NK) and natural killer T (NKT) cell lymphocyte populations were performed. Data were interpreted with ...

  9. Cytogenetic monitoring, radiosensitivity study and adaptive response of workers exposed to low level ionizing radiation

    International Nuclear Information System (INIS)

    The objectives of the present study were: To determine the frequencies of chromosome aberrations in lymphocytes from individuals belonging to professionally exposed groups, under normal conditions; to determine the possible differences in radiosensitivity between the lymphocytes of technicians and controls after in vitro irradiation with gamma rays during the G1 phase of the cell cycle (radiosensitivity study), and to examine the influence of in vivo and in vitro pre-exposure to low doses of radiation on the frequency of chromosome aberrations induced in vitro by high doses (study of the adaptive response) in a group of technicians (T) compared to controls (C). (author)

  10. Urinary 2,5-hexanedione in workers exposed to n-hexane: influence of the sample treatment

    Directory of Open Access Journals (Sweden)

    Daniela Magalhães Nolasco

    2007-08-01

    Full Text Available The aim of the present study was to determine 2,5-hexanedione (2,5-HD, a metabolite of n-hexane, by gas chromatography/flame ionization detection in 31 workers exposed to n-hexane after two types of sample pretreatment, i.e., with (total 2,5-HD and without (free 2,5-HD acid hydrolysis. The mean urinary 2,5-HD was 0.52 mg/L (free and 2.88 mg/L (total, this difference being significant (Student t-test, p < 0.05. The differences in the results according to the sample treatment support the need to modify the current Brazilian legislation, which proposes the analysis of 2,5-HD without indicating whether it is the free or total metabolite.

  11. Sample preparation and system calibration for proton-induced X-ray emission analysis of hair from occupationally exposed workers

    International Nuclear Information System (INIS)

    Blood and urine collections are commonly used to monitor trace element concentration in the body. Hair may also be used. The concentration of many elements is much higher in hair than in either blood or urine and may provide a ready record of a period of exposure to heavy metals. Proton-induced X-ray emission (PIXE) has been used to study trace elements in hair. A method of preparing samples by charring hair and mixing with yttrium-spiked graphite has been developed. Thick targets suitable for PIXE analysis are made. The trace elements K, Ca, Tl, Mn, Fe, Ni, Cu, Zn, Pb, Br, Rb, and Sr are routinely measured in most samples and Cr, Co, As, Bi, Se, Zr, and Cd can be measured in occupationally exposed workers. Helium backscattering and elastic recoil detection are used to determine the major component H, C, N, O, and S. 23 references, 5 figures, 3 tables

  12. Respiratory symptoms among industrial workers exposed to water aerosol. A pilot study of process water and air microbial quality

    Directory of Open Access Journals (Sweden)

    Bożena Krogulska

    2013-02-01

    Full Text Available Background: The frequency of respiratory symptoms in workers exposed to water aerosol was evaluated along with the preliminary assessment of microbiological contamination of air and water used in glass processing plants. Material and Methods: A questionnaire survey was conducted in 131 workers from 9 glass processing plants. Questions focused on working conditions, respiratory symptoms and smoking habits. A pilot study of air and water microbiological contamination in one glass processing plant was performed. Water samples were tested for Legionella in accordance with EN ISO 11731-2:2008 and for total colony count according to PN-EN ISO 6222:2004. Air samples were tested for total numbers of molds and mildews. Results: During the year preceding the survey acute respiratory symptoms occurred in 28.2% of participants, while chronic symptoms were reported by 29% of respondents. Increased risks of cough and acute symptoms suggestive of pneumonia were found among the respondents working at a distance up to 20 m from the source of water aerosol compared to other workers (OR = 2.7, with no difference in the frequency of other symptoms. A microbiological analysis of water samples from selected glass plant revealed the presence of L. pneumophila, exceeding 1000 cfu/100 ml. The number of bacteria and fungi detected in air samples (above 1000 cfu/m3 suggested that water aerosol at workplaces can be one of the sources of the air microbial contamination. Conclusions: The questionnaire survey revealed an increased risk of cough and acute symptoms suggestive of pneumonia in the group working at a shortest distance form the source of water aerosol. Med Pr 2013;64(1:47–55

  13. The Implications of a Health Promotion Program on the Knowledge and Practice of Automotive Workers Exposed To Solvent

    Directory of Open Access Journals (Sweden)

    Rumaizah Ruslan

    2010-01-01

    Full Text Available Problem statement: An in-house health promotion program aimed at promoting safety and health awareness when handling organic solvents at the workplace was carried out and its effectiveness was evaluated by comparing the Knowledge, Attitude and Practices (KAP scores at the pre and post-intervention phase. Approach: A total of 104 workers participated in the program and another 176 workers served as the comparative group. Questionnaire was distributed to respondents for the program evaluation on the KAP as well as to obtain their background information. The program consisted of small group lectures and discussions, a short video show, display of posters and distributions of pamphlets. Results: Pre-intervention data showed poor practice and knowledge scores on solvent hazards (Conclusion: There were improvements in the KAP scores of the intervention group at the post-intervention phase. However, the practice was not significantly correlated to the knowledge, instead, it was influenced by the employment years in the heavily solvent exposed sections in the Painting Department indicating that their job experience and peer group interactions contributed to their work culture and behavior.

  14. Leukotrienes in exhaled breath condensate and fractional exhaled nitric oxide in workers exposed to TiO2 nanoparticles.

    Science.gov (United States)

    Pelclova, Daniela; Zdimal, Vladimir; Kacer, Petr; Fenclova, Zdenka; Vlckova, Stepanka; Komarc, Martin; Navratil, Tomas; Schwarz, Jaroslav; Zikova, Nadezda; Makes, Otakar; Syslova, Kamila; Belacek, Jaroslav; Zakharov, Sergey

    2016-01-01

    Human health data regarding exposure to nanoparticles are extremely scarce and biomonitoring of exposure is lacking in spite of rodent pathological experimental data. Potential markers of the health-effects of engineered nanoparticles were examined in 30 workers exposed to TiO2 aerosol, 22 office employees of the same plant, and 45 unexposed controls. Leukotrienes (LT) B4, C4, E4, and D4 were analysed in the exhaled breath condensate (EBC) and urine via liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS). Fractional exhaled nitric oxide (FeNO) and spirometry was also measured. The median particle number concentration of the aerosol in the production ranged from 1.98  ×  10(4) to 2.32  ×  10(4) particles cm(-3); about 80% of the particles were  spirometry significant impairment in the workers was seen only for %VCIN and %PEF (both p  Spirometry was not sensitive enough. PMID:27356965

  15. Evaluation in vinyl chloride monomer-exposed workers and the relationship between liver lesions and gene polymorphisms of metabolic enzymes

    Institute of Scientific and Technical Information of China (English)

    Shou-Min Zhu; Xue-Feng Pen; Jun-Xiang Wan; Zhao-Lin Xia

    2005-01-01

    AIM: To analyze occupational health hazards exposure to doses lower than the Chinese occupational health standard in a selected VC polymerization plant in China,and also to elucidate the relationship between genetic polymorphisms and genetic susceptibility on liver lesions of workers exposed to vinyl chloride monomer (VCM).METHODS: In order to explore the mechanism of VCM-related health effects, we used a case-control design to investigate the association between the genetic polymorphisms of metabolic enzymes and liver lesions in workers occupationally exposed to VCM. Genotypes of CYP2E1, GSTT1, GSTM1, ALDH2 and ADH2 were identified using PCR and PCR-RFLP.RESULTS: Even when the concentration of VCM was lower than the current Chinese occupational health standard,neurasthenia, pharyngeal irritation, liver ultrasonography abnormalities and hemoglobin disorders were significantly higher in exposure subjects compared to non-exposure subjects, and the relative risks (RR and 95% CI) were 1.74 (1.06-2.85), 1.97 (1.56-2.48), 10.69 (4.38-26.12),and 2.07 (1.20-3.57). CYP2E1 c1c2/c2c2 genotype was significantly associated with liver damages (OR 3.29, 95% CI 1.51-7.20, P<0.01).CONCLUSION: The incidences of neurasthenia and liver ultrasonography abnormalities significantly increase when the cumulative exposure dose increases. The genotypes of metabolic enzymes (CYP2E1 c1c2/c2c2, null GSTT1 and ADH2 1-1) play important roles in VCM metabolism.Polymorphisms of CYP 2E1, GSTT1 and ADH2 may be a major reason of genetic susceptibility in VCM-induced hepatic damage.

  16. Mortality among 24,865 workers exposed to polychlorinated biphenyls (PCBs) in three electrical capacitor manufacturing plants: a ten-year update

    OpenAIRE

    Ruder Avima M; Hein Misty J; Hopf Nancy B.

    2014-01-01

    The objective of this analysis was to evaluate mortality among a cohort of 24,865 capacitor-manufacturing workers exposed to polychlorinated biphenyls (PCBs) at plants in Indiana, Massachusetts, and New York and followed for mortality through 2008. Cumulative PCB exposure was estimated using plant-specific job-exposure matrices. External comparisons to US and state-specific populations used standardized mortality ratios, adjusted for gender, race, age and calendar year. Among long-term worker...

  17. Influence of CYP2C9, GSTM1, GSTT1 and NAT2 genetic polymorphisms on DNA damage in workers occupationally exposed to organophosphate pesticides.

    Science.gov (United States)

    Singh, Satyender; Kumar, Vivek; Singh, Priyanka; Banerjee, Basu Dev; Rautela, Rajender Singh; Grover, Shyam Sunder; Rawat, Devendra Singh; Pasha, Syed Tazeen; Jain, Sudhir Kumar; Rai, Arvind

    2012-01-24

    Previous studies have revealed that organophosphate pesticides (OPs) are primarily metabolized by xenobiotic metabolizing enzymes (XMEs). Very few studies have explored genetic polymorphisms of XMEs and their association with DNA damage in pesticides-exposed workers. Present study was designed to determine the influence of CYP2C9, GSTM1, GSTT1 and NAT2 genetic polymorphisms on DNA damage in workers occupationally exposed to OPs. We examined 268 subjects including 134 workers occupationally exposed to OPs and an equal number of normal healthy controls. The DNA damage was evaluated using alkaline comet assay and genotyping was done using individual polymerase chain reaction (PCR) or polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Acetylcholinesterase and paraoxonase activity were found to be significantly lowered in workers as compared to control subjects which were analyzed as biomarkers of toxicity due to OPs exposure (p<0.001). Workers showed significantly higher DNA tail moment (TM) compared to control subjects (14.32±2.17 vs. 6.24±1.37 tail % DNA, p<0.001). GSTM1 null genotype was found to influence DNA TM in workers (p<0.05). DNA TM was also found to be increased with concomitant presence of NAT2 slow acetylation and CYP2C9*3/*3 or GSTM1 null genotypes (p<0.05). DNA TM was found increased in NAT2 slow acetylators with mild and heavy smoking habits in control subjects and workers, respectively (p<0.05). The results of this study suggest that GSTM1 null genotypes, and an association of NAT2 slow acetylation genotypes with CYP2C9*3/*3 or GSTM1 null genotypes may modulate DNA damage in workers occupationally exposed to OPs.

  18. Ophthalmological and angiographic findings in workers exposed to carbon disulfide (author's transl)

    Energy Technology Data Exchange (ETDEWEB)

    Savic, S.

    1982-01-01

    Microaneurysms are important in the diagnosis of vascular changes caused by carbon disulfide. They can be diagnosed by ophtholmoscopy, angiography or angioscopy. In our opinion even a careful ophthalmoscopic investigation is sufficient for diagnosis, so that angiography is not absolutely necessary for any mass survey. The incidence of microaneurysms correlates with the duration (both daily and total) as well as with the intensity of exposure to carbon disulfide. The quantity correlates closely with the intensity of exposure. The incidence of microaneurysms is not correlated to age; however it was found to be highest in 40-50-year-old men working with staple fibers, whereas in the spinning department it occurred in 50-55-old men. Microaneurysms are found equally frequently in active workers and invalids. There was no difference between the two groups with regard to degenerative changes of the macula. However, the changes found in the eyes of men from the staple fiber department were more pronounced than in those from the spinning department.

  19. Leukocyte subset analysis on blood from workers exposed to plutonium in 1944-45

    International Nuclear Information System (INIS)

    Monoclonal antibodies (MAbs) directed against cell surface markers were used to identify specific subpopulations of lymphocytes and monocytes obtained from 22 male subjects who had /sup 239/Pu exposures in 1944-45. Separated mononuclear cells were labelled simultaneously with fluoresceinated B1 (B cells), phycoerythrin Leu2a (T/sub S/ cells), LeμM3 with Texas-red goat-anti-mouse Ig and biotinylated Leμ3 with allophycocyanin avidin (T/sub H/ cells). In addition, the DNA-specific stain Hoechst 33342 was used to identify nucleated cells and to provide information on cell cycle status. Flow cytometric analysis using 3-color excitation (UV, 488 nm and 605 nm) was used, and 5 colors of emission were detected, corresponding to the four MAbs and Hoechst. The mononuclear cells were analyzed on the day of collection or after irradiation with 0, 50 or 200 rads followed by 6 days in culture with or without PHA stimulation. Marked differences in all measured parameters were found among the workers. The most striking response was a dose-related increase in the T/sub H//T/sub S/ ratio

  20. Long-term health effects of thorium compounds on exposed workers: the complete blood count

    International Nuclear Information System (INIS)

    Two hundred seventy-three men exposed to thorium and other rare earths between 1940 and 1973 at a plant which refined monazite sand were studied at Argonne National Laboratory from 1976 to 1980. In vivo measurements of body burden were made by counting gamma rays emitted by daughter products of retained thorium and by measuring exhaled thoron. Health status was ascertained through questionnaire, physical examination, and clinical laboratory tests. Measured body burden was found to be higher in those with a history of longer exposure. All parameters of the complete blood count were examined for evidence of an effect due to thorium. Comparisons of high and low body burden groups showed that only age and cigarette smoking had an effect on complete blood count parameters

  1. Blood Lead Levels and Cause-Specific Mortality of Inorganic Lead-Exposed Workers in South Korea.

    Directory of Open Access Journals (Sweden)

    Min-Gi Kim

    Full Text Available The objective of this study was to identify the association of blood lead level (BLL with mortality in inorganic lead-exposed workers of South Korea. A cohort was compiled comprising 81,067 inorganic lead exposed workers working between January 1, 2000, and December 31, 2004. This cohort was merged with the Korean National Statistical Office to follow-up for mortality between 2000 and 2008. After adjusting for age and other carcinogenic metal exposure, all-cause mortality (Relative risk [RR] 1.36, 95% confidence interval [CI] 1.03-1.79, digestive disease (RR 3.23, 95% CI 1.33-7.86, and intentional self-harm (RR 2.92, 95% CI 1.07-7.81 were statistically significantly higher in males with BLL >20 μg/dl than of those with BLL ≤10μg/dl. The RR of males with BLL of 10-20 μg/dl was statistically higher than of those with BLL ≤10μg/dl in infection (RR 3.73. 95% CI, 1.06-13.06. The RRs of females with 10-20 μg/dl BLL was statistically significantly greater than those with BLL <10μg/dl in all-cause mortality (RR 1.93, 95% CI 1.16-3.20 and colon and rectal cancer (RR 13.42, 95% CI 1.21-149.4. The RRs of females with BLL 10-20 μg/dl (RR 10.45, 95% CI 1.74-62.93 and BLL ≥20 μg/dl (RR 12.68, 95% CI 1.69-147.86 was statistically significantly increased in bronchus and lung cancer. The increased suicide of males with ≥20 μg/dl BLLs, which might be caused by major depression, might be associated with higher lead exposure. Also, increased bronchus and lung cancer mortality in female workers with higher BLL might be related to lead exposure considering low smoking rate in females. The kinds of BLL-associated mortality differed by gender.

  2. 35. Detection of numerical chromosome aberrations in sperm of workers exposed to benzene series by two-color fluorescence in situ hybridization

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    To study the frequency of numerical chromosome aberrations in sperm of workers exposed to benzene series, the aneuploidy frequencies of 9 and 18 chromosomes were detected in sperm of workers by two color fluorescence in situ hybridization with digoxingenin labeled 9 chromosome probe (D9zl) and biotin labeled 18 chromosome probe (D18zl). The timeweight average air concentration (TWA ) of benzene in the workplace was 86.49 mg/m3, it was two fold higher than the national maximum allowable concentration. The concentration of urinary trans,trans-muconic acid (ttMA) in exposed group was significantly higher than that of control group. The sperms counted in 14 exposed workers and 16 control workers were 136 401 and 156 955 respectively. The results showed that the disomy frequencies of sperm for chromosome 9, 18 in (0.168%±0.063% and 0.055%±0.031% respectively) and the frequency of diploidy sperm (0.073%±0.045%) were statistically increased over that of the control group(0.050%±0.030%; 0.033%±0.025% and 0.040%±0.036%, respectively). The nullisomic frequencies of 9,18 chromosome in the exposed group (0.206%±0.047%, 0.068%±0.044%) were statistically increased over that of the control group too (0.067%±0.037%, 0.048%±0.034%). The frequency of overall numerical chromosome aberrations in the exposed group was 0.570%±0.144%, when this value was compared with that of control (0.218%±0.071%), a statistically significance was presented. Our experiments showed that exposed to benzene at higher concentration may induce increase in aneuploidy frequency of sperm autosomal chromosome in exposed workers.

  3. High-performance Liquid Chromatographic Determination of Urinary Trans, Trans-Muconic Acid Excreted by Workers Occupationally Exposed to Benzene

    Institute of Scientific and Technical Information of China (English)

    XIA-MIN HU; SHI-ZHEN SONG; FANG-LI YE; LI-WEN LIU

    2006-01-01

    To investigate the relationship between trans, trans-muconic acid (ttMA) as benzene metabolite of occupational workers and benzene concentration in air. Methods A rapid and sensitive high-performance liquid chromatography was developed to determine the level of urinary ttMA. ttMA was extrated from urinary samples in liquid-liquid phase a ODS (2) (5u) column (Φ4.6 mm× 150 mm) and detected at wavelength 264 nm in a UV detector using vanillic acid as an internal standard. The mobile phase was acetaticacid/tetrahydrofuran/methanol/water (v/v, 1:2:10:87). The method was validated with 56 urine samples collected from occupationally benzene-exposed individuals. Results A correlation coefficient (r = 0.9963 ) was found for ttMA ranging 0.10-10.00 μg/mL. The limit of detection was 0.10 μg/mL. The recovery and reproducibility were generally over 90%. There was a positive correlation between ttMA and benzene level in air. The equation was Y=0.859+0.108C (before work, r=-0.6200) or Y=1.980+0.179C (after work, r=0.7930). Conclusion This method can be used to determine and control the level of urinary ttMA in those who are occupationally exposed to benzene.

  4. Pulmonary function in wood workers exposed to formaldehyde: a prospective study.

    Science.gov (United States)

    Alexandersson, R; Hedenstierna, G

    1989-01-01

    Employees exposed to formaldehyde in the woodworking industry (N = 47) and nonexposed control subjects (N = 20) were examined in 1980 by spirometry and the nitrogen washout technique. A transient impairment of lung function was noted over a work shift. Five years later, 21 subjects were still experiencing exposure to formaldehyde. A transient decrease in lung function was again found over a work shift, as evidenced by a reduction in forced mid-expiratory flow (FEF25-75) of 0.15 l/s and an increase in closing volume (CV%) of 3.0% in nonsmokers. Significant decreases in forced expired volume in 1 s as a percent of forced vital capacity (FEV1.0/FVC) and FEF25-75 were also noted over the 5 y in nonsmokers (0.4% and 0.2 l.s/y, respectively, after correction for normal aging). After 4 wk of no exposure (holidays), FEF25-75 and forced expired vital capacity (FVC, FEV1.0) returned to normal in the smoking group. Lung function in smokers improved less during the holiday. A dose-response relationship was found between exposure to formaldehyde and decrease in lung function. Thus, industrial exposure to formaldehyde causes transient lung function impairment over a work shift, with a cumulative effect over the years. The impairment, however, can be reversed with 4 wk of no exposure.

  5. Application of the Alara principle to the occupationally exposed workers in nuclear power plants

    International Nuclear Information System (INIS)

    This report sets down how the Alara (as low as reasonably achievable) principle is applied in radiation protection of the occupationally exposed personnel at light-water reactors in EC countries. In some instances the practices, experiences and results from EC countries are supplemented by the practice in other States (e.g. USA, Sweden). Commencing with a short summary of the legal situation in the Member States of the European Community with regard to Alara, the report describes the framework in which the optimization practice has been developed. The main chapters elaborate in detail how the Alara principle has been put into practice in design and operation in LWRs. The importance of qualification and training of power-plant personnel in relation to optimization of radiation protection is considered and some comparisons are drawn with the US practice. Recommendations are made where reason for modification or harmonization of practices is seen in the conclusions of the different chapters and the overall conclusions and summary of the report

  6. Association between Genetic Polymorphisms of DNA Repair Genes and Chromosomal Damage for 1,3-Butadiene-Exposed Workers in a Matched Study in China

    Directory of Open Access Journals (Sweden)

    Menglong Xiang

    2015-01-01

    Full Text Available The aim of the study was to examine the association between polymorphisms of DNA repair genes and chromosomal damage of 1,3-butadiene- (BD- exposed workers. The study was conducted in 45 pairs of occupationally exposed workers in a BD product workshop and matched control workers in an administrative office and a circulatory water workshop in China. Newly developed biomarkers (micronuclei, MNi; nucleoplasmic bridges, NPBs; nuclear buds, NBUDs in the cytokinesis-blocked micronucleus (CBMN cytome assay were adopted to detect chromosomal damage. PCR and PCR-restriction fragment length polymorphism (RFLP are adopted to analyze polymorphisms of DNA repair genes, such as X-ray repair cross-complementing Group 1 (XRCC1, O6-methylguanine-DNA methyltransferase (MGMT, poly (adenosine diphosphate-ribose polymerases (ADPRT, and apurinic/apyrimidinic endonucleases (APE1. The BD-exposed workers exhibited increased frequencies of MNi and NPBs when compared to subjects in the control group. The results also show that the BD-exposed workers carrying XRCC1 diplotypes TCGA-CCGG (4.25±2.06‰ (FR=2.10, 95% CI: 1.03–4.28 and TCGG-TCGA (5.80±3.56‰ (FR=2.75, 95% CI: 0.76–2.65 had statistically higher NBUD frequencies than those who carried diplotype TCGG-TCGG (1.89±1.27‰. Our study suggests that polymorphisms of XRCC1 gene may influence chromosomal damage in BD-exposed workers.

  7. Determining fitness to work after implantation of a cardiac defibrillator in a worker exposed to magnetic fields; Quelle conduite tenir apres l'implantation d'un defibrillateur cardiaque chez un travailleur expose aux champs magnetiques?

    Energy Technology Data Exchange (ETDEWEB)

    Magne, I. [Electricite de France, R and D, Lab. des Materiels Electriques, 77 - Moret sur Loing (France); Souques, M. [Electricite de France, EDF-Gaz de France, Service des Etudes Medicales, 75 - Paris (France); Hero, M. [MEDTRONIC France, 92 - Boulogne-Billancourt (France)

    2007-04-15

    An EDF worker potentially exposed to high-intensity 50 Hz magnetic fields had a cardiac defibrillator implanted. Theoretically its operation could be disturbed by magnetic field exposure at work. We use this case study to present an approach to evaluating work safety and the worker's fitness in such situations. The protocol consisted of measuring the magnetic field at the different places where the worker performed his job duties, in his presence, and simultaneously monitoring the operation of the device. The Medtronic device was programmed in bipolar mode. Throughout the workplace, the maximal magnetic field intensity measured at the device level was 650 {mu}T. No dysfunction was recorded in bipolar mode. Following these measurements and device controls, the worker was declared fit and resumed his previous job. Two years later, no incident has been reported. (authors)

  8. Cytogenotoxicity of Abattoir Effluent in Clarias gariepinus (Burchell, 1822 Using Micronucleus Test

    Directory of Open Access Journals (Sweden)

    Chibuisi G. Alimba

    2015-01-01

    Full Text Available The cytogenotoxic potential of abattoir effluent from Bodija, Nigeria, was investigated using micronucleus test in Clarias gariepinus. Fish was exposed to five different concentrations: 0.2, 0.4, 0.8, 1.6, and 3.1% of the effluent for 7, 14, and 28 days. Tap water and 0.02 mL/L of benzene were used as negative and positive controls, respectively. Physicochemical parameters and heavy metals were analyzed in the effluent in accordance with standard methods. After exposure, blood was collected from the treated and control fish and slides were prepared for micronuclei (MN and nuclear abnormality evaluation in the peripheral erythrocytes. The effluent induced significant (p<0.05 increase in the frequency of MN in a time dependent manner. Similarly, the frequency of total nuclear abnormalities (blebbing, notch, bud, binucleation, and vacuolation was higher in the exposed fish than the negative control. Electrical conductivity, nitrate, biochemical oxygen demand, chemical oxygen demand, arsenic, and copper analyzed in the effluent may have provoked the observed cytogenetic damage. The findings herein suggest the presence of clastogens and cytotoxins in Bodija abattoir wastewater which are capable of increasing genomic instability in aquatic biota.

  9. - On Investigating Pollution of Groundwater from Atenda Abattoir Wastes, Ogbomoso, Nigeria

    OpenAIRE

    Adewoye, Abosede Olufunmilayo; Adegbola, Adedayo Ayodele

    2012-01-01

    The incidence of waterborne diseases arising from pollution of shallow wells in abattoir environment has been on the increase in Ogbomoso community. This project work was carried out in order to examine the geochemical constituents of water samples taken from selected wells in Atenda abattoir environment, Ogbomoso, Oyo State, Nigeria. The effect of abattoir wastes on the groundwater samples and geotechnical analyses of soil samples taken from two points around the abattoir waste dump, and ano...

  10. Plasma dioxin levels and cause-specific mortality in an occupational cohort of workers exposed to chlorophenoxy herbicides, chlorophenols and contaminants

    NARCIS (Netherlands)

    Boers, D.; Portengen, L.; Turner, W.E.; Bueno-de-Mesquita, H.B.; Heederik, D.; Vermeulen, R.

    2012-01-01

    BACKGROUND: We recently reported increased risks for all cancers and urinary cancers in workers exposed to chlorophenoxy herbicides using data from the Dutch herbicide cohort study. These risks could not be linked to the qualitative exposure proxies available. Here, we re-investigate exposure-respon

  11. Estimation of risk of developing bladder cancer among workers exposed to coal tar pitch volatiles in the primary aluminum industry.

    Science.gov (United States)

    Tremblay, C; Armstrong, B; Thériault, G; Brodeur, J

    1995-03-01

    To confirm the relationship between exposure to coal tar pitch volatiles and bladder cancer among primary aluminum production workers, we carried out a case-control study among blue-collar workers who had worked more than 1 year between 1950-1979 in a major plant using mostly the Soderberg process in the Province of Québec. Cases of bladder cancer (ICD code 188) diagnosed between 1970-1979 (n = 69) were mostly included in a previously reported study. To these were added cases diagnosed between 1980-1988 (n = 69). Each case was matched to three controls on date of birth, date of hiring, and length of service at the company. Smoking habits were assessed from the medical records at the company. Benzene-soluble matter (BSM) and benzo(a)pyrene (BaP) were used as indicators of environmental exposure to coal tar pitch volatiles in the workplace. The estimated risk for current smokers was 2.63 (95% C.I. 1.29-5.37). Estimates of risk by occupational exposure were adjusted for smoking. Men who had worked in the Soderberg potrooms were at higher risk of developing the disease, the risk increasing with the time spent in these departments. Similarly, a strong association between risk and cumulative exposure to BSM or to BaP was observed. The risks associated with cumulative exposure to BSM (mg/m3-years) and to BaP (microgram/m3-years) were described with mathematical models. Using a linear model (1 + bx) and lagging 10 years before the diagnosis, BaP cumulative exposure was a better indicator of risk than BSM cumulative exposure. The risk for each year of exposure to BaP at a concentration of 1 microgram/m3 increased by 1.7% (0.8%-3.2%). Using the same model for BSM, a worker exposed to the current threshold limit value of 0.2 mg/m3 for 40 years will sustain a risk of 2.22 (1.56-3.48). Comparison of risks according to different periods of diagnosis (1970-1979 vs. 1980-1988) did not reveal any significant temporal changes on risk estimates.

  12. Neopterin: A candidate biomarker for the early assessment of toxicity of aluminum among bauxite dust exposed mine workers

    Directory of Open Access Journals (Sweden)

    Shubhangi K Pingle

    2015-01-01

    Full Text Available Introduction: Bauxite ore is a major source of aluminum (Al which contains approximately 35–60% Al by weight. Occupational and environmental bauxite dust exposure may cause toxicity by interaction with human biological systems resulting in oxidative stress (OS and cell death. A neopterin derivative as an antioxidant is able to modulate cytotoxicity by the induction of OS. Materials and Methods: A total of 273 subjects were selected for blood collection from three different major Al producing bauxite mines and were categorized into three groups as experimental (Exp (n = 150, experimental controls (ExC (n = 73 and control (Con (n = 50. Whole blood and serum samples were used for measurement of Al, neopterin, urea and creatinine values. Statistical analysis was performed using R-2.15.1 programming language. Results and Discussion: The result showed that age, body mass index and the behavioral habits, that is, smoking, tobacco and alcohol consumption have possible effects on neopterin level. Serum neopterin levels were found to be significantly higher (P <0.0001 in the experimental group as compared to other groups. Significantly positive correlation (P < 0.0001 was observed between neopterin and creatinine. It was also observed that neopterin level increases as the duration of exposure increases. Conclusion: On the basis of findings it was concluded that exposure to bauxite dust (even at low levels of Al changes biochemical profile leading to high levels of serum neopterin. Levels of serum neopterin in workers exposed to bauxite dust were probably examined for the 1st time in India. The outcome of this study suggested that serum neopterin may be used as potential biomarker for early detection of health risks associated with bauxite dust exposed population.

  13. Nerve conduction, visual evoked responses and electroretinography in tunnel workers previously exposed to acrylamide and N-methylolacrylamide containing grouting agents.

    Science.gov (United States)

    Goffeng, Lars Ole; Heier, Mona Skard; Kjuus, Helge; Sjöholm, Hans; Sørensen, Kjell Aage; Skaug, Vidar

    2008-01-01

    The study examines possible persisting effects on the peripheral nervous system and visual system in tunnel workers previously exposed to acrylamide and N-methylolacrylamide during grouting work. We compared neurophysiological function in 44 tunnel workers previously exposed during grouting operations (2-10 years post exposure), with 49 tunnel workers with no history of exposure to acrylamide. Nerve conduction velocities (NCV), distal delay, F-response and amplitude in median and ulnar nerves of the right arm, peroneal, sural and tibial nerves of the right leg, visual evoked response (VER) and electroretinography (ERG) were measured. VER and ERG were also performed in 24 subjects more recently exposed to acrylamide grout (16 months post exposure). Exposure to acrylamide containing grouts was assessed by questionnaires. A statistically significant reduction in the mean sensory NCV of the sural nerve (p=0.005), as well as a non-significant reduction of sural amplitude was found in the previously exposed group compared to the control group. VER latencies to the onset of the occipital potential (N75) were prolonged in both exposed groups compared to the control group (pgrouting operations. PMID:18353610

  14. The relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Myers Jonathan E

    2006-08-01

    Full Text Available Abstract Background The utility of blood reproductive endocrine biomarkers for assessing or estimating semen quality was explored. Methods A cross-sectional study of 47 DDT exposed malaria vector control workers was performed. Tests included blood basal and post gonadotrophin releasing hormone (GnRH, lutenizing hormone (LH, follicle stimulating hormone (FSH, testosterone, sex hormone binding globulin (SHBG, estradiol (E2 and inhibin; a questionnaire (demographics and general medical history; a physical examination and semen analysis. Semen parameters were determined using either/or or both WHO or the strict Tygerberg criteria. Relationships between semen parameters and endocrine measures were adjusted for age, duration of abstinence before sampling, presence of physical abnormalities and fever in the last two months. All relationships between specific endocrine hormones were adjusted for age and basal SHBG. Results Multiple logistic regression showed a consistent positive relationship (prevalence odds ratio (POR = 8.2, CI:1.4–49.2 between low basal inhibin ( POR 50 pg/ml and abnormal morphology (proportion Conclusion The study has demonstrated that low basal inhibin, elevated basal FSH and high basal E2 can serve as markers of impaired semen quality.

  15. Elemental bio-imaging of thorium, uranium, and plutonium in tissues from occupationally exposed former nuclear workers.

    Science.gov (United States)

    Hare, Dominic; Tolmachev, Sergei; James, Anthony; Bishop, David; Austin, Christine; Fryer, Fred; Doble, Philip

    2010-04-15

    Internal exposure from naturally occurring radionuclides (including the inhaled long-lived actinides (232)Th and (238)U) is a component of the ubiquitous background radiation dose (National Council on Radiation Protection and Measurements. Ionizing radiation exposure of the population of the United States; NCRP Report No. 160; NCRP: Bethesda, MD, 2009). It is of interest to compare the concentration distribution of these natural alpha-emitters in the lungs and respiratory lymph nodes with those resulting from occupational exposure, including exposure to anthropogenic plutonium and depleted and enriched uranium. This study examines the application of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICPMS) to quantifying and visualizing the mass distribution of uranium and thorium isotopes from both occupational and natural background exposure in human respiratory tissues and, for the first time, extends this application to the direct imaging of plutonium isotopes. Sections of lymphatic and lung tissues taken from deceased former nuclear workers with a known history of occupational exposure to specific actinide elements (uranium, plutonium, or americium) were analyzed by LA-ICPMS. Using a previously developed LA-ICPMS protocol for elemental bio-imaging of trace elements in human tissue and a new software tool, we generated images of thorium ((232)Th), uranium ((235)U and (238)U), and plutonium ((239)Pu and (240)Pu) mass distributions in sections of tissue. We used a laboratory-produced matrix-matched standard to quantify the (232)Th, (235)U, and (238)U concentrations. The plutonium isotopes (239)Pu and (240)Pu were detected by LA-ICPMS in 65 mum diameter localized regions of both a paratracheal lymph node and a sample of lung tissue from a person who was occupationally exposed to refractory plutonium (plutonium dioxide). The average (overall) (239)Pu concentration in the lymph node was 39.2 ng/g, measured by high purity germanium (HPGe) gamma

  16. Elemental bio-imaging of thorium, uranium, and plutonium in tissues from occupationally exposed former nuclear workers.

    Science.gov (United States)

    Hare, Dominic; Tolmachev, Sergei; James, Anthony; Bishop, David; Austin, Christine; Fryer, Fred; Doble, Philip

    2010-04-15

    Internal exposure from naturally occurring radionuclides (including the inhaled long-lived actinides (232)Th and (238)U) is a component of the ubiquitous background radiation dose (National Council on Radiation Protection and Measurements. Ionizing radiation exposure of the population of the United States; NCRP Report No. 160; NCRP: Bethesda, MD, 2009). It is of interest to compare the concentration distribution of these natural alpha-emitters in the lungs and respiratory lymph nodes with those resulting from occupational exposure, including exposure to anthropogenic plutonium and depleted and enriched uranium. This study examines the application of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICPMS) to quantifying and visualizing the mass distribution of uranium and thorium isotopes from both occupational and natural background exposure in human respiratory tissues and, for the first time, extends this application to the direct imaging of plutonium isotopes. Sections of lymphatic and lung tissues taken from deceased former nuclear workers with a known history of occupational exposure to specific actinide elements (uranium, plutonium, or americium) were analyzed by LA-ICPMS. Using a previously developed LA-ICPMS protocol for elemental bio-imaging of trace elements in human tissue and a new software tool, we generated images of thorium ((232)Th), uranium ((235)U and (238)U), and plutonium ((239)Pu and (240)Pu) mass distributions in sections of tissue. We used a laboratory-produced matrix-matched standard to quantify the (232)Th, (235)U, and (238)U concentrations. The plutonium isotopes (239)Pu and (240)Pu were detected by LA-ICPMS in 65 mum diameter localized regions of both a paratracheal lymph node and a sample of lung tissue from a person who was occupationally exposed to refractory plutonium (plutonium dioxide). The average (overall) (239)Pu concentration in the lymph node was 39.2 ng/g, measured by high purity germanium (HPGe) gamma

  17. A review of job-exposure matrix methodology for application to workers exposed to radiation from internally deposited plutonium or other radioactive materials.

    Science.gov (United States)

    Liu, Hanhua; Wakeford, Richard; Riddell, Anthony; O'Hagan, Jacqueline; MacGregor, David; Agius, Raymond; Wilson, Christine; Peace, Mark; de Vocht, Frank

    2016-03-01

    Any potential health effects of radiation emitted from radionuclides deposited in the bodies of workers exposed to radioactive materials can be directly investigated through epidemiological studies. However, estimates of radionuclide exposure and consequent tissue-specific doses, particularly for early workers for whom monitoring was relatively crude but exposures tended to be highest, can be uncertain, limiting the accuracy of risk estimates. We review the use of job-exposure matrices (JEMs) in peer-reviewed epidemiological and exposure assessment studies of nuclear industry workers exposed to radioactive materials as a method for addressing gaps in exposure data, and discuss methodology and comparability between studies. We identified nine studies of nuclear worker cohorts in France, Russia, the USA and the UK that had incorporated JEMs in their exposure assessments. All these JEMs were study or cohort-specific, and although broadly comparable methodologies were used in their construction, this is insufficient to enable the transfer of any one JEM to another study. Moreover there was often inadequate detail on whether, or how, JEMs were validated. JEMs have become more detailed and more quantitative, and this trend may eventually enable better comparison across, and the pooling of, studies. We conclude that JEMs have been shown to be a valuable exposure assessment methodology for imputation of missing exposure data for nuclear worker cohorts with data not missing at random. The next step forward for direct comparison or pooled analysis of complete cohorts would be the use of transparent and transferable methods.

  18. Genetic polymorphisms of GSTM1, GSTT1 and GSTP1 and susceptibility to DNA damage in workers occupationally exposed to organophosphate pesticides.

    Science.gov (United States)

    Singh, Satyender; Kumar, Vivek; Singh, Priyanka; Thakur, Sachin; Banerjee, Basu Dev; Rautela, Rajender Singh; Grover, Shyam Sunder; Rawat, Devendra Singh; Pasha, Syed Tazeen; Jain, Sudhir Kumar; Rai, Arvind

    2011-10-01

    GSTM1, T1 and P1 are important enzymes of glutathione S-transferases (GSTs), involved in the metabolism of many endogenous and exogenous compounds. Individual genetic variation in these metabolizing enzymes may influence the metabolism of their substrates. The present study was designed to determine the genotoxic effects using DNA damage and its association with GSTM1, GSTT1, and GSTP1 (Ile105Val) genetic polymorphisms in workers occupationally exposed to organophosphate pesticides (OPs). We examined 230 subjects including 115 workers occupationally exposed to OPs and an equal number of normal healthy controls. The DNA damage was evaluated using the alkaline comet assay and genotyping was done using individual PCR or PCR-RFLP. Significantly higher DNA tail moment (TM) was observed in workers as compared to control subjects (14.41 ± 2.25 vs. 6.36 ± 1.41 tail % DNA, p<0.001). The results revealed significantly higher DNA TM in workers with GSTM1 null genotype than those with GSTM1 positive (15.18 vs. 14.15 tail % DNA, p=0.03). A significantly higher DNA TM was also observed in workers with homozygous Ile-Ile GSTP1 genotype than heterozygous (Ile-Val) and mutant (Val-Val) GSTP1 genotype (p=0.02). In conclusion, the results show that null deletion of GSTM1 and homozygote wild GSTP1 genotype could be related to inter-individual differences in DNA damage arises from the gene-environment interactions in workers occupationally exposed to OPs.

  19. Study of Peak Expiratory Flow Rate as the Assessment of Lung Function in Occupationally Exposed Petrol Pump Workers of Western Maharashtra

    Directory of Open Access Journals (Sweden)

    Patil Smita V

    2016-04-01

    Full Text Available Background: Fast urbanization trends, rapid industrial growth, globalization, and poor environmental conditions at work places have created a lot of healthrelated issues. Aim and Objectives: The aim of this study is to investigate Peak Expiratory Flow Rate (PEFR as the assessment of lung function in occupationally exposed petrol pump workers and also check whether PEFR increases or decreases with duration of exposure. Material and Methods: The study was conducted on 60 male petrol pump workers between age group of 20-40 years who were working as petrol filling attendants for more than one year from western Maharashtra. 50 normal healthy males with same socioeconomic status were chosen as controls to find out the effect of occupational exposure to petroleum product on PEFR as the assessment of lung function tests. Petrol pump workers were divided into three groups based on their duration of exposure i.e. 1- 5 yrs, 6- 10 yrs and more than 11 years. PEFR of petrol pump workers and control was measured by using a Mini Wright peak flow meter which is a portable device for measuring ventilator functions. Comparisons was done using unpaired t-test for 2 groups comparisons and one way ANOVAfor multiple groups of exposures. Results: The PEFR was significantly lower decrease (p=0.001 around petrol pump workers (389.17 as compared to control (534.2. As year of exposure increased mean value of PEFR was significantly decreased from 452.17, 378.00 and 283.64 respectively in petrol pump workers. Conclusion: The results suggested that respiratory functions i.e. PEFR of occupationally exposed petrol pump workers are significantly reduced as compared to controls, also PEFR is significantly reduced with increase in the duration of exposure.

  20. Associations between DNA methylation in DNA damage response-related genes and cytokinesis-block micronucleus cytome index in diesel engine exhaust-exposed workers.

    Science.gov (United States)

    Zhang, Xiao; Li, Jie; He, Zhini; Duan, Huawei; Gao, Weimin; Wang, Haisheng; Yu, Shanfa; Chen, Wen; Zheng, Yuxin

    2016-08-01

    Recently, diesel engine exhaust (DEE) was reclassified as a known carcinogen to humans. DNA methylation alterations in DNA damage response (DDR)-related genes have the potential to affect DEE exposure-related cancer risk. However, the evidence regarding the association between DEE exposure and methylation alterations in DDR-related genes is limited. In 117 DEE-exposed workers and 112 non-DEE-exposed workers, we measured urinary concentrations of six mono-hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs). We also determined the methylation levels of three DDR-related genes (p16, RASSF1A, and MGMT) and LINE-1 by bisulfite-pyrosequencing assay. We found that DEE-exposed workers exhibited significantly lower mean promoter methylation levels of p16, RASSF1A, and MGMT than non-DEE-exposed workers (all p < 0.001). In all study subjects and non-smoking workers, increasing quartiles of urinary summed OH-PAHs was associated with hypomethylation of p16, RASSF1A, and MGMT (all p < 0.05). In non-smoking workers, methylation in p16, RASSF1A, and MGMT decreased by 0.36 % [95 % confidential interval (CI): -0.60, -0.11 %], 0.46 % (95 % CI: -0.79, -0.14 %), and 0.55 % (95 % CI: -0.95, -0.15 %), respectively, in association with highest versus lowest quartile of urinary summed OH-PAHs. In addition, p16, RASSF1A, MGMT, and LINE-1 methylation levels showed negative correlations with cytokinesis-block micronucleus cytome index which was previously measured in the same workers (all p < 0.05). In conclusion, our results clearly indicated that DEE exposure and increased genetic damage were associated with hypomethylation of p16, RASSF1A, and MGMT. Future studies with larger sample size are needed to confirm these associations. PMID:26410583

  1. Study of Peak Expiratory Flow Rate as the Assessment of Lung Function in Occupationally Exposed Petrol Pump Workers of Western Maharashtra

    OpenAIRE

    Patil Smita V; Sumangala Patil; Sampada Kanitkar

    2016-01-01

    Background: Fast urbanization trends, rapid industrial growth, globalization, and poor environmental conditions at work places have created a lot of healthrelated issues. Aim and Objectives: The aim of this study is to investigate Peak Expiratory Flow Rate (PEFR) as the assessment of lung function in occupationally exposed petrol pump workers and also check whether PEFR increases or decreases with duration of exposure. Material and Methods: The study was conducted o...

  2. Cohorte poblacional de trabajadores expuestos a amianto: Navarra 1999-2004 Cohort of asbestos exposed workers: Navarre (Spain 1999-2004

    Directory of Open Access Journals (Sweden)

    L. Artieda

    2005-12-01

    Full Text Available Fundamento. La construcción de una cohorte poblacional de trabajadores expuestos a amianto es importante porque facilita la vigilancia, permite cumplir con la obligación ética de reconocer el origen laboral de las lesiones y contribuye al desarrollo de la investigación científica. El objetivo es describir el procedimiento que se ha seguido para identificar a los trabajadores expuestos a amianto en Navarra y conocer su respuesta a la oferta de vigilancia de la salud. Metodología. El registro de trabajadores expuestos a amianto se crea en 1999, incorporando empresas y trabajadores a partir de las fuentes de información disponibles, de ámbito nacional y regional, y se consolida con la búsqueda activa de expuestos, tanto activos como inactivos. Resultados. La cohorte es de 2.294 trabajadores, de 33 empresas; 40% están activos, la mitad trabajan fabricando vehículos de motor, 91% expuestos a crisotilo, 25% expuestos a concentraciones de fibras de amianto iguales o superior a 0,20 por cm³ de crisotilo ó 0,10 para otros. En los años 70 y 90 es cuando mayor número de trabajadores inicia la exposición; quienes comenzaron en los años 40 y 50 tienen tiempos de exposición más altos. En la vigilancia médica 72% acepta la oferta, con mayor participación de los activos. Conclusiones. La creación de la cohorte y su seguimiento han permitido reconocer el triple de casos de patología por amianto en relación con los declarados espontáneamente en los once años anteriores al programa, lo que refleja su importancia. El nivel de aceptación de la vigilancia es adecuado, dada la metodología del programa.Background. The identification of a population cohort of workers exposed to asbestos is important because it facilitates health surveillance, allowing us to fulfil the ethical obligation of recognizing the occupational origin of the illness and contributing to the development of scientific research. The goal of this study is to identify the

  3. Serum Neuron-Specific Enolase, Biogenic Amino-Acids and Neurobehavioral Function in Lead-Exposed Workers from Lead-Acid Battery Manufacturing Process

    Directory of Open Access Journals (Sweden)

    K Ravibabu

    2015-01-01

    Full Text Available Background: The interaction between serum neuron-specific enolase (NSE, biogenic amino-acids and neurobehavioral function with blood lead levels in workers exposed to lead form lead-acid battery manufacturing process was not studied.Objective: To evaluate serum NSE and biogenic amino-acids (dopamine and serotonin levels, and neurobehavioral performance among workers exposed to lead from lead-acid storage battery plant, and its relation with blood lead levels (BLLs.Methods: In a cross-sectional study, we performed biochemical and neurobehavioral function tests on 146 workers exposed to lead from lead-acid battery manufacturing process. BLLs were assessed by an atomic absorption spectrophotometer. Serum NSE, dopamine and serotonin were measured by ELISA. Neurobehavioral functions were assessed by CDC-recommended tests—simple reaction time (SRT, symbol digit substitution test (SDST, and serial digit learning test (SDLT.Results: There was a significant correlation (r 0.199, p<0.05 between SDST and BLL. SDLT and SRT had also a significant positive correlation (r 0.238, p<0.01. NSE had a negative correlation (r –0.194, p<0.05 with serotonin level. Multiple linear regression analysis revealed that both SRT and SDST had positive significant associations with BLL. SRT also had a positive significant association with age.Conclusion: Serum NSE cannot be used as a marker for BLL. The only domain of neurobehavioral function tests that is affected by increased BLL in workers of lead-acid battery manufacturing process is that of the “attention and perception” (SDST.

  4. ABSENCE OF MUTAGENICITY IN THE URINE OF AUTOPSY SERVICE WORKERS EXPOSED TO FORMALDEHYDE: FACTORS INFLUENCING MUTAGENICITY TESTING OF URINE

    Science.gov (United States)

    The study examined the effect of exposure to autopsy workers to formaldehyde using urinary mutagenicity testing with Salmonella typhimurium. A matched control group was also studied. Additional studies including the recovery of histidine from urine samples, the determination of h...

  5. Mutagenic activity and polycyclic aromatic hydrocarbon levels in urine of workers exposed to coal tar pitch volatiles in an anode plant.

    Science.gov (United States)

    Venier, P; Clonfero, E; Cottica, D; Gava, C; Zordan, M; Pozzoli, L; Levis, A G

    1985-05-01

    The mutagenicity of urinary extracts and the excretion of PAH from workers occupationally exposed to coal tar pitch volatiles in an anode plant were analyzed. Mutagenicity of the urinary extracts was measured by means of the plate test using S. typhimurium strain TA 98. After concentration, hydrolysis and reduction of the urine samples, PAH levels were measured by high resolution gas chromatography/mass spectrometry. No significant difference was found in the mutagenicity of the urinary extracts of non-smokers occupationally exposed to PAH as compared with the controls. Low PAH concentrations were found in the urine of the exposed subjects, which lends further support to the negative results obtained with the Ames' test. The increase of urinary PAH excretion, in relation to occupational exposure, was mainly due to the less mutagenic, low molecular weight compounds.

  6. Investigation of Sarcocystis Infection in Slaughtered Goats in Jahrom Abattoir

    OpenAIRE

    Zahra Kargar Jahromi; Kavous Solhjoo; Mohammad Zareian Jahromi; Hossein Kargar Jahromi; Saiedeh Erfaniyan; Masoud Esmi

    2012-01-01

    Background and Objective: Sarcocyst infection is one of the most common zoonotic protozoan diseases caused by different Sarcocystis spp. Given the importance of this infection in public health, the infection rate of macroscopic and microscopic sarcocysts in slaughtered goats was determined in Jahrom abattoir. Materials and Methods : Between April and June in 2011, six tissues including the esophagus, tongue, diaphragm, shoulder muscles, thigh muscles, and heart of 4925 slaughtered goats were ...

  7. Feasibility study of respiratory questionnaire and peak flow recordings in autobody shop workers exposed to isocyanate-containing spray paint: observations and limitations.

    Science.gov (United States)

    Cullen, M R; Redlich, C A; Beckett, W S; Weltmann, B; Sparer, J; Jackson, G; Ruff, T; Rubinstein, E; Holden, W

    1996-06-01

    Diisocyanates, highly reactive monomers which cross-link polyurethane, are the most widely recognized causes of occupational asthma. Many exposed workers are end-users, including autobody spray painters who form a large population at risk. Neither the factors which determine incidence rate nor strategies for control have been adequately studied in this setting. We have conducted a cross-sectional survey of 23 (about one in five) autobody shops in the New Haven area to determine the feasibility of clinical epidemiological studies in this population. Among 102 workers, there was a high rate of airway symptoms consistent with occupational asthma (19.6%). Symptoms were most prevalent among those with the greatest opportunity for exposure (dedicated spray painters) and least among office workers; part-time painters had intermediate rates. Atopy was not associated with risk while smoking seemed to correlate with symptoms. Regular use of air-supplied respirators appeared to be associated with lower risk among workers who painted part- or full-time. We were unable to validate the questionnaire responses with peak expiratory flow record data attempted on a 1/3 sample of the workers. Despite intensive training and effort, subject compliance was limited. Among those who provided adequate data (24 of 38), only two demonstrated unequivocal evidence of labile airways; two others demonstrated lesser changes consistent with an occupational effect on flow rates. There was no clear association between these findings and either questionnaire responses or exposure classification. Overall, the survey suggests that there is a high prevalence of airway symptoms among workers in autobody shops, at least in part due to work-related asthma. However, there is need for both methodological and substantive research in this setting to document rates of occupational asthma and to develop a scientific basis for its effective control. PMID:8695771

  8. Food safety knowledge, attitude, and practice toward compliance with abattoir laws among the abattoir workers in Malaysia

    OpenAIRE

    Abdullahi A; Hassan A; Kadarman N; Saleh A; Baraya YS; Lua PL

    2016-01-01

    Auwalu Abdullahi,1–3 Azmi Hassan,1 Norizhar Kadarman,2 Ahmadu Saleh,4 Yusha’u Shu’aibu Baraya,5 Pei Lin Lua,61Institute for Community Development and Quality of Life  (i-CODE), Universiti Sultan Zainal Abidin (UniSZA), Kampus Gong Badak, Kuala Terengganu, Terengganu, Malaysia; 2Faculty of Medicine, Department of Community Medicine, Universiti Sultan Zainal Abidin (UniSZA), Kampus Kota, Jalan Sultan Mahmud, Kuala Terengganu, Terengganu, Malaysia; 3Departm...

  9. 某体温计厂汞作业工人健康状况分析%Mercury-Exposed Workers' Health Status in a Thermometer Manufacturing Plant

    Institute of Scientific and Technical Information of China (English)

    秦宏; 何恩奇; 张金龙; 朱玮; 周进红

    2011-01-01

    [Objective]To investigate the health status of workers exposed to mercury in a thermometer manufacturing plant.[Methods]Detect the air concentrations of mercury in the thermometer factory and perform health examinations on 147 mercury-exposed workers.[Results]Part of the air mercury concentrations in workplace exceeded the national occupational health standards.The mercury vapor concentrations of 16 selected monitoring points are higher than the national occupational health standard; 48 mercury-exposed workers showed neural symptoms, and the prevalence was 32.65%( 48/147 ).Total of 28 mercuryexposed workers had the mouth-gum disease, and the prevalence was 19.05%( 28/147 ).The urine mercury of 122 mercury-exposed workers exceeded the national occupational health standards, the average urinary mercury was ( 129.83 ± 82.14 )μg/g creatinine.[Conclusion]The company should take further effective preventive measures to prevent and control chronic mercury poisoning.%[目的]调查某体温计厂汞作业职工的健康状况.[方法]检测某体温计厂工作场所空气中汞浓度,并对147名汞作业工人进行职业健康检查.[结果]部分工作场所空气中汞浓度超过国家职业卫生标准,重汞作业岗位的封头、制坯下、涨真空岗位的采样点汞蒸气浓度超过国家职业卫生标准;48名汞作业工人具有类神经征,检出率32.65%(48/147),28人具有口腔-牙龈炎,检出率19.05%(28/147),122名汞作业工人尿汞超标,尿汞平均值为(129.83±82.14)μg/g肌酐.[结论]该体温计厂汞作业环境汞蒸气超标,作业工人慢性汞中毒症状和体征检出率较高,企业必须采取有效的职业病防治措施,保护工人的健康.

  10. Radiation surveillance of exposed workers during activities of moving of the earth area of Montecillo; Vigilancia radiologica de los trabajadores expuestos durante las actividades de movimiento de tierras del area del Montecillo del CIEMAT

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz, M. T.; Alvarez, A.; Garcia, E.; Diaz, P.; Quinones, J.

    2013-07-01

    One of the objectives of this study was to limit the doses received by exposed workers and the public (in this case the workers of the CIEMATs buildings next to the work) by setting the appropriate criteria of optimization and protection.In addition was a theoretical evaluation of the dose inhalation, workers would have received if ALARA study protection measures has not been established. (Author)

  11. Avian influenza virus H9N2 seroprevalence and risk factors for infection in occupational poultry-exposed workers in Tai'an of China.

    Science.gov (United States)

    Li, Song; Zhou, Yufa; Song, Wengang; Pang, Quanhai; Miao, Zengmin

    2016-08-01

    To determine risk factor for H9N2 avian influenza virus (AIV) infection, a serological surveillance among both occupational poultry-exposed (OPE) workers and general humans was carried out using both haemagglutination inhibition (HI) and microneutralization (MN) assays in Tai'an, China, between 2011 and 2013. At baseline, the positive rate of anti-H9 antibody (HI and MN titers ≥40) among OPE workers (51/600, 8.5%) was significantly higher than that among the general population (11/600, 1.8%). The result indicated that occupational exposure to chicken flocks was an important risk factor for H9N2 AIV infection. J. Med. Virol. 88:1453-1456, 2016. © 2016 Wiley Periodicals, Inc. PMID:26816053

  12. Evaluación bioquímica de trabajadores rurales expuestos a pesticidas Biochemical evaluation on rural workers exposed to pesticides

    Directory of Open Access Journals (Sweden)

    María Fernanda Simoniello

    2010-12-01

    Full Text Available Los pesticidas utilizados en agricultura pueden representar un riesgo potencial para la salud de los agricultores expuestos y para el medio ambiente. El objetivo de este trabajo fue evaluar trabajadores frutihortícolas expuestos a plaguicidas, categorizados por: exposición directa (n = 45, exposición indirecta (n = 50 y controles (n = 50 mediante biomarcadores de exposición y efecto: colinesterasa (ChE, acetilcolinesterasa (AChE, catalasa (CAT, peroxidación de lípidos (TBARS, Indice de Daño Ensayo Cometa (IDEC e Indice de Daño Ensayo Reparación (IDER. Los resultados indican: a inhibición significativa de AChE (p Pesticides are used in agriculture to protect crops but may represent a potential risk to farmers and the environment. The aim of this work was to evaluate horticultural workers exposed to pesticide, categorized by: direct exposure (n = 45, indirect exposure (n = 50 and controls (n = 50 using exposure and effect biomarkers: cholinesterase (ChE, acetylcholinesterase (AChE, catalase (CAT, lipid peroxidation (TBARS, Damage Index Comet Assay (IDEC and Damage Index Repair Assay (IDER. Our results show: a an AChE inhibition in directly and indirectly exposed population (p < 0.001, b significant increase in the levels of TBARS in direct exposure (p < 0.001, c the CAT reduction was significant (p < 0.01, d a significant increase in IDEC and IDER in both exposed groups (p < 0.001. Our results evidence variations in oxidative balance and DNA damage in exposed workers. These findings represent a contribution to the sub-clinical evaluation of subjects exposed to agrochemicals in our country.

  13. Analysis on the neurobehavioral function of vanadium-exposed workers%钒化合物对作业工人神经行为功能影响

    Institute of Scientific and Technical Information of China (English)

    封承勇; 周鼎伦; 兰亚佳; 黄升; 王治明

    2012-01-01

    目的 探讨接触钒化合物对工人神经行为功能的损害作用及表现特征.方法 采用WHO推荐的神经行为测试组合(NCTB)对暴露组和对照组做测试,其中接钒工人193人,对照组273人.结果 ①暴露组代表消极情感的“紧张-焦虑”、“抑郁-沮丧”、“愤怒-敌意”、“疲劳-惰性”、“困惑-迷茫”得分均高于对照组,代表积极情感的“有力-好动”得分低于对照组,差异有统计学意义(P<0.05).②顺背数字、圣地安娜提转敏捷度、数字译码、视觉保留、目标追踪,均是暴露组得分低于对照组(P<0.05).③简单反应时两组间差异无统计学意义(P>0.05).结论 钒作业工人神经行为功能测试差于对照组工人,表现在消极情绪增加、积极情绪降低,视觉记忆力下降、运动速度减慢、运动稳定性下降,提示钒接触有可能造成神经行为功能的损害.%OBJECTIVE To explore the characteristics of neurobehavioral functions of workers exposed to vanadium compound. METHODS WHO-NCTB was applied to evaluate the neurobehavioral functions of all subjects. 193 vanadium-exposed workers and 273 non-exposed workers were recruited. RESULTS ① The scores of positive mood in exposure group, including tension-anxiety, depress-dejection, anger-hostility, fatigue-inertia and confusion-bewilderment, which were significantly higher than those of control group. The scores of negative moods, named "Vigor-activity", in exposure group were lower than control group. ② Digit span in forward, Santa Ana dexterity, Benton visual retention and pursuit aiming II in exposure group were significantly lower than those in control group. ③ As simple reaction time, no significant difference was observed between exposed group and unexposed group. CONCLUSION Score of neurobehavioral function test on vanadium-exposed workers was lower than non-exposed workers, including disorder of mood states, vision-memory, motor speed and motor

  14. Plasma Cytokine Concentrations in Workers Exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

    NARCIS (Netherlands)

    Saberi Hosnijeh, F.; Boers, D.; Portengen, L.; Bueno-de-Mesquita, H.B.; Heederik, D.; Vermeulen, R.

    2012-01-01

    Objectives: Few epidemiological studies have studied the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on blood cytokine levels. In this study we investigated changes in plasma levels of a large panel of cytokines, chemokines, and growth factors among workers from a Dutch historical cohort oc

  15. Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM)-exposed workers

    OpenAIRE

    Fen Wu; Jing Liu; Yu-Lan Qiu; Wei Wang; Shou-Min Zhu; Pin Sun; Wen-Bin Miao; Yong-Liang Li; Brandt-Rauf, Paul W.; Zhao-Lin Xia

    2013-01-01

    Objective: To explore the association of the methylation status of MGMT and hMLH1 with chromosome damage induced by vinyl chloride monomer (VCM). Materials and Methods: Methylation of MGMT and hMLH1 was measured in 101 VCM-exposed workers by methylation-specifi c PCR. Chromosome damage in peripheral blood lymphocytes was measured by the cytokinesis-block micronucleus assay. The subjects were divided into chromosome damaged and non-damaged groups based on the normal reference value of micronuc...

  16. Sintomatología persistente en trabajadores industrialmente expuestos a plaguicidas organofosforados Persistent symptomatology in workers industrially exposed to organophosphate pesticides

    Directory of Open Access Journals (Sweden)

    Martha Edilia Palacios-Nava

    1999-01-01

    Full Text Available Objetivo. Describir los patrones de ocurrencia de sintomatología persistente en trabajadores industrialmente expuestos a plaguicidas organofosforados. Material y métodos. Se realizó un estudio descriptivo, transversal y observacional. Se aplicó un cuestionario a las autoridades de la empresa y otro a 89 trabajadores a quienes se les determinó el nivel de colinesterasa sanguínea con los métodos Magnotti y Lovibond. Para la descripción de la información se elaboraron tasas, medidas de tendencia central y de dispersión. Para evaluar la diferencia entre grupos se utilizó la prueba ji² y se calculó razón de momios. Resultados. La prevalencia de sintomatología persistente fue de 6.3 por cada 10 trabajadores; 50% tuvo seis síntomas o más. No se encontraron diferencias estadísticamente significativas en el riesgo de padecer sintomatología persistente de acuerdo con la edad, antigüedad, área de trabajo y puesto. No obstante, las proporciones más altas de síntomas se encontraron en los trabajadores de 31 a 40 años de edad, con 6 a 13 años de antigüedad en la fábrica, en el área de mantenimiento y en los puestos de obrero general y supervisor. En los 13 trabajadores que tuvieron antecedentes de intoxicación previa, la prevalencia de sintomatología persistente fue de 6.9 contra 6.1 de los que nunca se habían intoxicado. El riesgo de intoxicación aguda previa entre quienes tenían más de 14 años de antigüedad en la empresa fue cuatro veces mayor que el de aquellos con menos de 14 años (pObjective. To describe the patterns of persistent symptomatology in workers industrially exposed to organophosphate pesticides. Material and Methods. An observational, descriptive and cross-sectional study was performed. A questionnaire was applied to managers of a factory and to 89 workers, whose erythrocytic cholinesterase level was measured with the Magnotti and Lovibond method. Information is described through rates, central tendency

  17. Shared Resilience in a Traumatic Reality: A New Concept for Trauma Workers Exposed Personally and Professionally to Collective Disaster.

    Science.gov (United States)

    Nuttman-Shwartz, Orit

    2015-10-01

    This article proposes a new concept, shared resilience in a traumatic reality (SRTR), which refers to trauma workers in shared reality situations. Based on the literature that emphasizes the positive effects of exposure to traumatic events for workers in this field, this article expands the perception of shared traumatic situations and examines the ability of trauma workers to cope, to show resilience, and to grow as a result of the mutual relationship with their clients. The literature review presents a variety of terms referring to the positive effects of working with trauma survivors on therapists as a basis for the new concept proposed here. These terms highlight the importance of empathic mutual aid relationships, which are a basic component for promoting resilience in a shared traumatic reality. The relative nature of shared resilience is discussed, bearing in mind that resilience can be manifested as emotions, behaviors, and conceptions. Various findings relating to shared resilience in traumatic situations are reviewed, and recommendations for research, practice, and policy are offered. PMID:25427830

  18. Correlation between gene polymorphisms of IL-2, IL-6 and TNF-α in workers exposed to rare earth dust and their lung ventilation function

    International Nuclear Information System (INIS)

    Objective: To study the relationship between lung ventilation function of workers exposed to rare earth dust and their IL-2, IL-6 and TNF-α gene polymorphism. Methods: TNF-α gene polymorphism were identified by RFLP-PCR, IL-2 and IL-6 gene polymorphisms were identified by PCR-CTPP analysis. Lung ventilation function was deteced by instrument of ventilation function. Results: Compared with controls, there was no statistic significance in frequencies distribution of TNF-α gene polymorphism (χ2=4.03, P>0.05), IL-2 gene polymorphism (χ2=2.21, P>0.05) and IL-6 gene polymorphism (χ2=1.05, P>0.05). Compared with IL-2 gene wild type, IL-2 homozygote type increased the risk of lung ventilation dysfunction by 4.29 folds (95% CI 1.09 ∼ 16.9). Conclusions: Compared with controls,incidence of ventilation function of workers exposed to rare earth dust is in ascending trend. IL-2 (G/G) gene type induces more serious inflammation reaction than the others. (authors)

  19. Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM-exposed workers

    Directory of Open Access Journals (Sweden)

    Fen Wu

    2013-02-01

    Full Text Available Objective: To explore the association of the methylation status of MGMT and hMLH1 with chromosome damage induced by vinyl chloride monomer (VCM. Materials and Methods: Methylation of MGMT and hMLH1 was measured in 101 VCM-exposed workers by methylation-specifi c PCR. Chromosome damage in peripheral blood lymphocytes was measured by the cytokinesis-block micronucleus assay. The subjects were divided into chromosome damaged and non-damaged groups based on the normal reference value of micronuclei frequencies determined for two control groups. Results: MGMT promoter methylation was detectable in 5 out of 49 chromosome damaged subjects, but not in the chromosome non-damaged subjects; there was a signifi cant difference in MGMT methylation between the two groups (p < 0.05. Conclusions: We detected aberrant promoter methylation of MGMT in a small number of chromosome damaged VCM-exposed workers, but not in the chromosome non-damaged subjects. This preliminary observation warrants further investigation in a larger study.

  20. Seroprevalence of leptospires in sheep slaughtered at Sokoto metropolitan Abattoir

    Directory of Open Access Journals (Sweden)

    G. Bashiru

    2013-03-01

    Full Text Available In a study to determine the seroprevalence of leptospiralantibodies in sheep slaughtered at Sokoto metropolitan abattoir, Nigeria, bloodwas collected from 282 sheep made up of both male and female. The serum wascollected and analysed using an antigen coated IgG ELISA, out of which 20 tested positive by the ELISA giving anoverall prevalence of 7.1%. Prevalences recorded for age was 18.48% for ≤ 2yrsand 1.58% for > 2yrs, and sex was 3.09% for male and 12.50% for females.There was a significant (P

  1. Screening for occupational vitiligo in workers exposed to hydroquinone monomethyl ether and to paratertiary-amyl-phenol

    Energy Technology Data Exchange (ETDEWEB)

    O' Sullivan, J.J.; Stevenson, C.J.

    1981-11-01

    Two men reported previously with vitiligo after occupational exposure to hydroquinone monomethyl ether (HMME) have been reviewed after eight years. Repigmentation of significant degree was found in one man and of limited degree in the other. One hundred and sixty-nine men in the same works have been screened with Wood's light for evidence of vitiligo. No cases were found in the 148 men exposed to HMME (colleagues who screened 100 men exposed to HMME in two other factories also found no case) or in the 129 who had been exposed to paratertiary-amyl-phenol. Loss of light reflection on Wood's light examination was observed in 13 men due to scars or to other skin disorders.

  2. Genetic Instability in Lymphocytes is Associated With Blood Plasma Antioxidant Levels in Health Care Workers Occupationally Exposed to Ionizing Radiation.

    Science.gov (United States)

    Kumar, Dayanidhi; Kumari, Sandhya; Salian, Sujith Raj; Uppangala, Shubhashree; Kalthur, Guruprasad; Challapalli, Srinivas; Chandraguthi, Shrinidhi Gururajarao; Kumar, Pratap; Adiga, Satish Kumar

    2016-05-01

    Earlier reports have suggested that exposure to radiation at workplace may induce cytogenetic abnormalities. However, the association between plasma antioxidants and the cytogenetic abnormalities in these patients has not been elucidated till now. Hence, the present study was undertaken to determine the relationship between the cytogenetic abnormalities, plasma antioxidant system, and the radiation exposure levels in men who were occupationally exposed to ionizing radiation. The study included 134 male volunteers, among whom 83 were occupationally exposed to ionizing radiation. Incidence of micronuclei and chromosomal aberration was assessed in lymphocytes. Total and reduced glutathione (GSH), total antioxidant capacity (TAC), superoxide dismutase (SOD), and lipid peroxidation were assessed in the plasma. The micronuclei frequency and chromosomal aberrations were significantly higher in the exposed group in comparison to the nonexposed group (P stress to protect somatic cell genetic integrity. PMID:26758870

  3. Clinical, cytogenetic and toxicological studies in rural workers exposed to pesticides in Botucatu, São Paulo, Brazil Estudos clínicos, citogenéticos e toxicológicos em trabalhadores rurais expostos a pesticidas em Botucatu, São Paulo, Brasil

    OpenAIRE

    Salete Marcia Bréga; Igor Vassilieff; Alaor Almeida; Amauri Mercadante; Denise Bissacot; Paulo R. Cury; Dertia V. Freire-Maia

    1998-01-01

    Pesticides can cause gene mutations and chromosomal aberrations in exposed individuals. We have investigated 24 workers exposed to pesticides. Clinical examinations and cytogenetic and toxicological tests were performed. Ten non-exposed individuals were used as controls. Toxicological dosages of copper, zinc and manganese (metals found in some pesticides), hepatic enzyme dosage (GOT, GPT, AR) and acetylcholinesterase activity were performed in 16 workers and 8 controls. In the exposed workers...

  4. Bio-toxicological supervision op workers exposed to lead poisoning hazard. Systematic examination of amino acids, in urine and plasma

    International Nuclear Information System (INIS)

    A bio-toxicological chart was established for the workers in a firm handling lead. The known facts concerning professional lead poisoning are outlined, after which the importance of lead work in a nuclear center is discussed. The work station of each man is described and the results of analyses made during atmospheric checks on the site are given with sampling techniques. Since the biological chart is centered on the chromatographic exploration of amino acids in blood and urine, the analytical technique used is described and the different technical modifications made to the standard technique reported. The results obtained on reference subjects are compared with those found in the specialized literature. The results found in lead workers are then presented in the form of histograms, which better illustrate the differences observed with respect to the reference subjects. An hematological and toxicological balance-sheet is drawn up and the correlation existing between the results of coproporphyrine, lead and delta-aminolevulinic acid analyses in urine is checked. Biological detection of lead-poisoning has the advantage of providing an early diagnosis, thus enabling the works doctor to forestall the effects of this professional disease before any clinical symptoms appear. (author)

  5. Mortality among workers exposed to coal tar pitch volatiles and welding emissions: an exercise in epidemiologic triage.

    Science.gov (United States)

    Silverstein, M; Maizlish, N; Park, R; Mirer, F

    1985-11-01

    The United Automobile Workers International Union has established a system of epidemiologic triage to evaluate patterns of mortality among groups of union members. In response to worker concerns, the Union examined mortality at a metal stamping plant, using a method which linked pension records with the State of Michigan computerized death registry. The observed proportion of malignant neoplasms was nearly twice that expected (95% Confidence Limits 1.36, 2.62). Two- to five-fold excess proportional mortality from cancer of the digestive organs, lung cancer, and leukemia accounted for most of the overall excess. Strong associations were found between lung and digestive organ cancer and employment as maintenance welders or millwrights in the plant (odds ratios greater than 10). High levels of six polycyclic aromatic hydrocarbons with mutagenic and carcinogenic properties were found during hot coal tar application to wood block floors, work conducted by the high-risk groups. These levels were substantially reduced following the purchase of new tar pots. The example demonstrates that epidemiologic tools can play a valuable role in occupational health decision making, but care must be taken to avoid mechanical reliance on quantitative testing and to acknowledge the important role of social and political value judgments in the establishment of responsible public policy.

  6. Mortality over an extended follow-up period in coal workers exposed to respirable dust and quartz

    Energy Technology Data Exchange (ETDEWEB)

    Miller, B.G.; MacCalman, L.; Hutchison, P.A.

    2009-10-15

    In the 1950s the Pneumoconiosis Field Research (PFR) programme was set up to study the health of British coalworkers. Studies included regular health surveys, an intensive characterisation of workers' individual exposures, and entry to a cohort followed up to the present for cause-specific mortality. This study reports on analyses of cause-specific mortality in a cohort of almost 18,000 men from 10 collieries. External analyses used standardised mortality ratios, comparing observed mortality with reference rates from the regions in which the pits were situated. Causes investigated include lung and stomach cancers, nonmalignant respiratory diseases, and cardiovascular endpoints. Internal analyses used Cox regression models with time-dependent exposures adjusting for the confounding effects of age, smoking, cohort entry date and regional differences in population mortality rates. Several causes showed evidence of a healthy worker effect early in the follow-up, with a deficit in the SMR diminishing over time. For most of the causes there was a significant excess in the latter part of follow-up. Internal analyses found evidence of an association between increased risks of lung cancer and increased quartz exposure, particularly at a lag of 15 years. Risks of mortality from non-malignant respiratory disease, and specifically chronic obstructive pulmonary disease and pneumoconiosis, showed increases with increased exposure to respirable dust. 60 refs.

  7. Prevalence of bovine Cysticercosis of Slaughtered Cattle in Meshkinshahr Abattoir

    Directory of Open Access Journals (Sweden)

    Y. Garedaghi

    2011-01-01

    Full Text Available Problem statement: The occurrence of the larvae of Taenia saginata (T. saginata in cattle musculature causes T. saginata cysticercosis or bovine cysticercosis while the adult worms in human small intestines cause taeniasis. Approach: In this study, the prevalence of Taenia saginata cysticercosis in cattle slaughtered for meat in Meshkinshahr Abattoir, Iran between September 2010 and August 2011 was reported. Results: The examination of various organs of 500 cattle in Meshkinshahr Abattoir showed that 15(3% were infected with T. saginata cysticercosis. The tongue, masseter muscles, cardiac muscles, triceps muscles and thigh muscles were the main predilection sites of the cysts. The cysts of bovine cysticercosis were also identified on the spleen, intercostal muscles, diaphragm and liver. Out of 460 male cattle, examined, 14 (3% had cysts of bovine cysticercosis while 1 (2.5% of the 40 female animals investigated were infected. Conclusion: The animals slaughtered were all adults. No significant difference in prevalence rates was recorded between the sexes. The prevalence of bovine cysticercosis was higher in local sarabi cattle breeds than Holstein-Frisian cattle.

  8. [Noise-related occupational risk aboard fishing vessels: considerations on prevention and the protection of exposed workers].

    Science.gov (United States)

    Rapisarda, V; Valentino, M; Bolognini, S; Fenga, C

    2004-01-01

    Recent legislation regarding the safety of workers aboard fishing vessels requires the appointment by ship owners of a Reference Physician in charge of health surveillance, preventive inspections and related tasks. As maritime workers, especially fishermen, have always been excluded from legal protection of occupational health, there are no exhaustive data on the incidence of their occupational disease. Several epidemiological studies of fishermen have evidenced a high prevalence and incidence of occupational conditions, among which noise-related hypoacousia. We report data of a phonometric survey conducted aboard six fishing vessels carrying a crew of less than six fishing in the mid-Adriatic. Measurements were performed during fishing and navigation aboard five vessels fitted with a fixed-pitch propeller and during fishing only aboard one vessel fitted with an controllable pitch propeller. Measurements were conducted: 1) in the engine rooms; 2) in the work area on deck; 3) at the winch; 4) in the wheelhouse; 5) in the mess-room and kitchen; 6) in the sleeping quarters. Results show that the equivalent sound pressure level in the engine rooms consistently exceeded 90 dBA on all vessels. The speed of the vessels fitted with the fixed-pitch propeller is 3-4 knots in the fishing phase and around 10 knots during navigation to and from the fishing grounds; noise emission is lower with the former regimen because of the smaller number of engine revolutions per minute. Our survey demonstrated considerably different noise levels in the various areas of vessels. One key element in workers' exposure, the tasks assigned and the environmental working conditions is of course the type of fishing in which the vessel is engaged. Further phonometric studies are required to assess the daily level of exposure per crew member, which represents the reference for the noise-related risk of each subject. Knowledge of the sound pressure levels in the work environment and the length of

  9. An overview of male reproductive studies of boron with an emphasis on studies of highly exposed Chinese workers

    DEFF Research Database (Denmark)

    Scialli, Anthony R; Bonde, Jens Peter; Brüske-Hohlfeld, Irene;

    2010-01-01

    Boron treatment of rats, mice, and dogs has been associated with testicular toxicity, characterized by inhibited spermiation at lower dose levels and a reduction in epididymal sperm count at higher dose levels. The no-adverse-effect level for reproductive effects in male rats is 17.5mg B/kg bw...... working in boron (B) mining or processing in Liaoning province in northeast China has been published in several Chinese and a few English language papers. This study included individual assessment of boron exposure, interview data on reproductive experience and semen analysis. Employed men living...... in the same community and in a remote community were used as controls. Boron workers (n=75) had a mean daily boron intake of 31.3mg B/day, and a subset of 16 of these men, employed at a plant where there was heavy boron contamination of the water supply, had an estimated mean daily boron intake of 125 mg B...

  10. Saúde auditiva de trabalhadores expostos a ruído e inseticidas Hearing health of workers exposed to noise and insecticides

    Directory of Open Access Journals (Sweden)

    Cleide Fernandes Teixeira

    2003-08-01

    Full Text Available OBJETIVO: Avaliar as alterações auditivas periféricas em um grupo de trabalhadores exposto a inseticidas, organofosforados e piretróides, utilizados em campanhas de controle de vetores. MÉTODOS: Estudo de prevalência de uma população de 98 indivíduos que pulverizavam venenos nas campanhas de prevenção do dengue, da febre amarela e da doença de Chagas. A amostra foi de tipo finalística, considerando o universo dos trabalhadores de um distrito sanitário, em Pernambuco, no ano de 2000. Utilizou-se questionário contendo questões de identificação de riscos ocupacional e não ocupacional, medidas de segurança utilizadas, antecedentes de problemas auditivos e sintomas referidos. Foi investigada a historia pregressa de exposição ao ruído, por ser um fator de confusão para a perda auditiva. Todos os indivíduos foram avaliados pelo teste de audiometria tonal. RESULTADOS: Dos expostos apenas aos inseticidas, 63,8% apresentaram perda auditiva. Para o grupo com exposição concomitantemente aos inseticidas e ao ruído, a perda auditiva foi de 66,7%. O tempo mediano para o desenvolvimento de alterações auditivas nas freqüências médias altas, para as exposições combinadas de inseticidas e ruído, foi de 3,4 anos e para as exposições apenas aos inseticidas foi de 7,3 anos. A perda auditiva para as exposições concomitantes aos dois fatores foi de maior intensidade nessas freqüências, do que o observado na exposição apenas aos inseticidas. CONCLUSÕES: Há evidência de que a exposição aos inseticidas induz dano auditivo periférico e que o ruído é um fator que interage com os inseticidas, potencializando seus efeitos ototóxicos. Faz-se necessário avaliar essa possível associação através de estudos epidemiológicos de caráter analítico.OBJECTIVE: To examine the peripheral auditory disorders in a group of workers exposed to organophosphate and pyrethroid insecticides, used in vector control campaigns. METHODS: The

  11. Perfil de 300 trabalhadores expostos à sílica atendidos ambulatorialmente em Belo Horizonte Profile of 300 workers exposed to silica seen in an university outpatient clinic

    Directory of Open Access Journals (Sweden)

    ANA PAULA SCALIA CARNEIRO

    2002-11-01

    Full Text Available Introdução: A silicose é a pneumoconiose de maior prevalência no Brasil, sendo a maioria dos casos proveniente do Estado de Minas Gerais. Apesar de ser uma doença evitável, continuam ocorrendo epidemias localizadas. Objetivo: Descrever o perfil dos trabalhadores atendidos no Ambulatório de Doenças Profissionais do Hospital das Clínicas da Universidade Federal de Minas Gerais. Material e métodos: Foram estudados 300 prontuários de trabalhadores expostos à sílica em diversas atividades profissionais, atendidos no período de 1989 a 2000, sendo analisados dados clínico-ocupacionais, espirométricos e radiológicos. Realizaram-se análises univariadas, utilizando o teste do qui-quadrado e teste t. Resultados e conclusão: A média de idade dos pacientes expostos foi de 51 anos, com tempo médio de exposição de 15,6 anos. Diagnosticaram-se radiologicamente 126 (42% casos de silicose, constatando-se que, quanto mais avançada a categoria radiológica da doença, piores foram os resultados à espirometria e mais freqüentes as associações com tuberculose e com limitação crônica ao fluxo aéreo. O mercado de trabalho formal representou o principal vínculo empregatício, sendo a mineração a principal atividade exercida, responsável pela exposição de 197 indivíduos (66%. Os trabalhadores do mercado informal foram aqueles que apresentaram achados radiológicos indicativos de formas mais avançadas da doença, sugerindo piores condições de exposição à sílica, neste grupo de trabalhadores.Introduction: Silicosis is the most prevalent pneumoconiosis in Brazil, with most of the registered cases occurring in the State of Minas Gerais. Although it is a preventable disease, silicosis is still epidemic in some areas. Objective: To describe the profile of workers seen at the Clinics Hospital of the Federal University of Minas Gerais. Patients and methods: 300 medical records of silica-exposed workers in different occupations, seen

  12. Animal Models in Studies of Cardiotoxicity Side Effects from Antiblastic Drugs in Patients and Occupational Exposed Workers

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    Monica Lamberti

    2014-01-01

    Full Text Available Cardiotoxicity is an important side effect of cytotoxic drugs and may be a risk factor of long-term morbidity for both patients during therapy and also for staff exposed during the phases of manipulation of antiblastic drugs. The mechanism of cardiotoxicity studied in vitro and in vivo essentially concerns the formation of free radicals leading to oxidative stress, with apoptosis of cardiac cells or immunologic reactions, but other mechanisms may play a role in antiblastic-induced cardiotoxicity. Actually, some new cytotoxic drugs like trastuzumab and cyclopentenyl cytosine show cardiotoxic effects. In this report we discuss the different mechanisms of cardiotoxicity induced by antiblastic drugs assessed using animal models.

  13. Sister-chromatid exchanges and cell-cycle kinetics in the lymphocytes of workers occupationally exposed to a chemical mixture in the tyre industry.

    Science.gov (United States)

    Sasiadek, M

    1993-08-01

    Cytogenetic studies of clinically healthy workers employed in the rubber industry showed an increase in chromosome aberrations (CAs), sister-chromatid exchanges (SCEs) and a decrease in proliferation indices (PIs). The aim of the present study was to establish, using the SCE and PI tests, genotoxic effects of hazardous chemicals in the rubber industry. An increase in mean SCEs in the lymphocytes of vulcanizers as compared to controls was observed. Since the PI in the exposed group was insignificantly decreased as compared to the controls, it could be concluded that the SCE test is the most sensitive cytogenetic test for the detection of a genotoxic effect of chemicals in the rubber industry. There was no evidence in the present study that the genotoxic effect of chemicals in the rubber industry was enhanced by cigarette smoking. PMID:7688857

  14. 双酚A对接触男工精液质量的影响%Effect of bisphenol A on semen quality of exposed workers: a pilot study

    Institute of Scientific and Technical Information of China (English)

    肖国兵; 王仁元; 蔡耀章; 何国华; 周志俊

    2009-01-01

    Objective To explore the semen quality of the workers exposed to the xenoestrogen bisphenol A( BPA) was explored. Methods A cross-sectional study of 20 BPA exposed and 16 control workers with similar age,physical activities was performed. Tests included quantifying BPA in blood samples and investigating the quantity and quality of semen. Semen parameters were determined with the method recommended by WHO. Results 94.4% exposed workers were found BPA in blood, and the median was 101.94 μg/L However, only 18.8% control subjects were found BPA in blood, and the median level was 0 μg/L. The sperm density of exposed workers [(68.65±44.00)×10~6/ml] was significantly lower than that of control [(118.56±98.36 )×l0~6/ml]. Relationship analysis showed the positive relationships (r=0.44, P<0.01) between the sperm with quick forward progression and BPA level in blood, negative relationships between the percentage of normal sperm and BPA level in blood (r=-0.62,P=0.01). Conclusion BPA could affect the sperm density, and may influence the semen quality. More research should be performed on the effect and the mechanism of BPA on man.%目的 探讨双酚A(BPA)对接触男工精液质量的影响.方法 选择20名接触BPA的工人作为职业接触组,另选择与接触组年龄、职业和体力活动相匹配,但不接触BPA和其他可能损伤生殖功能的物理或化学因素的16名造型工人作为对照组.采集被调查对象的血液,检测其血液中BPA水平,按WHO推荐方法分析精液质量. 结果94.4%的接触组工人血液中检出BPA,中位数为101.94 μg/L,而对照组仅有18.8%的工人血液中检出BPA,中位数为0 μg/L.接触组精子密度[(68.65±44.00)×106个/ml]明显低于对照组[(118.56±98.36)×10~6个/ml],差异有统计学意义(P<0.05),而其他精液和精子质量指标则未见明显差异.相关分析结果表明,精子快速前向运动与血液中BPA水平呈正相关(r=0.44,P<0.01),精子正常率与

  15. Publication of new results from the INWORKS epidemiological study about the risk of cancer among nuclear industry workers chronically exposed to low ionizing radiation doses

    International Nuclear Information System (INIS)

    In this cohort study, 308297 workers in the nuclear industry from France, the United Kingdom, and the United States with detailed monitoring data for external exposure to ionising radiation were linked to death registries. Excess relative rate per Gy of radiation dose for mortality from cancer was estimated. Follow-up encompassed 8.2 million person years. Of 66632 known deaths by the end of follow-up, 17?957 were due to solid cancers. Results suggest a linear increase in the rate of cancer with increasing radiation exposure. The average cumulative colon dose estimated among exposed workers was 20.9 mGy (median 4.1 mGy). The estimated rate of mortality from all cancers excluding leukaemia increased with cumulative dose by 48% per Gy (90% confidence interval 20% to 79%), lagged by 10 years. Similar associations were seen for mortality from all solid cancers (47% (18% to 79%)), and within each country. The estimated association over the dose range of 0-100 mGy was similar in magnitude to that obtained over the entire dose range but less precise. Smoking and occupational asbestos exposure are potential confounders; however, exclusion of deaths from lung cancer and pleural cancer did not affect the estimated association. Despite substantial efforts to characterise the performance of the radiation dosimeters used, the possibility of measurement error remains. The study provides a direct estimate of the association between protracted low dose exposure to ionising radiation and solid cancer mortality. Although high dose rate exposures are thought to be more dangerous than low dose rate exposures, the risk per unit of radiation dose for cancer among radiation workers was similar to estimates derived from studies of Japanese atomic bomb survivors. Quantifying the cancer risks associated with protracted radiation exposures can help strengthen the foundation for radiation protection standards

  16. The role of radiation regulatory agencies of the Republic of the Philippines in the education and training of workers occupationally exposed to radiation

    International Nuclear Information System (INIS)

    In the Republic of the Philippines, there are two national radiation regulatory agencies. One is the Philippine Nuclear Research Institute (PNRI) which has the regulatory mandate over radioactive materials. The other one is the Bureau of Health Devices and Technology (BHDT) which has the regulatory mandate over radiation devices. Since a major requirement in regulating use of radiation sources is the appropriate qualification of the workers occupationally exposed to radiation, the paper discusses the strategies and activities of these two agencies to ensure that these workers have the necessary education and training to do their work properly. Some of these are the conduct of training courses in cooperation with the relevant professional societies, conduct of distance aided training in cooperation with the IAEA, initiation and active involvement in the establishment and continued existence of the masteral degree program in medical physics which was established with IAEA technical assistance, assistance to lawmakers in drafting pertinent legislation, and creation of joint technical working groups to ensure harmonization of standards and regulations, among others. The Philippines has adopted a national policy that users of radiation and radioactive materials have the primary responsibility for radiation safety. The PNRI and the BHDT have adopted strategies which have been very useful in the effective implementation of their regulations. (author)

  17. Adverse respiratory health and hematological alterations among agricultural workers occupationally exposed to organophosphate pesticides: a cross-sectional study in North India.

    Directory of Open Access Journals (Sweden)

    Mohd Fareed

    Full Text Available BACKGROUND: Non-protective work practices followed by farm workers during spraying of pesticides lead to occupational exposure among them. OBJECTIVE: This study is designed to explore the respiratory health and hematological profile of agricultural workers occupationally exposed to OP pesticides. MATERIALS AND METHODS: A cross sectional study was undertaken among 166 pesticide sprayers working in mango orchards of Lucknow district in North India compared with 77 controls to assess the respiratory illness, lung functions, cholinesterase levels and hematological profile. A questionnaire based survey and clinical examination for respiratory health were conducted among study subjects. Lung function test was conducted among study subjects by using spirometer. Cholinesterase level as biomarker of OP pesticides and hematological profile of study subjects were investigated in the laboratory by following the standard protocols. RESULTS: Overall respiratory morbidity observed among exposed subjects was 36.75%. Symptoms for respiratory illness like dry cough, productive cough, wheezing, irritation of throat and blood stained sputum were found to be significantly more (p<0.05 among pesticide sprayers than controls. Lung function parameters viz. PEFR, FEV1, %PEFR predicted, %FEV1 predicted and FEV1/FVC were found to be significantly decreased (p<0.05 among pesticide sprayers as compared to controls. Exposure wise distribution of respiratory illness and lung functions among pesticide sprayers show that the exposure duration significantly elevates (p<0.05 the respiratory problems and significantly decreases (p<0.001 lung functions among pesticide sprayers. Activities of acetylcholinesterase and butyrylcholinesterase were found to be significantly depleted (p<0.001 among pesticide sprayers as compared to controls which show the exposure of OP pesticides among them. The hematological profile viz. RBC, WBC, monocytes, neutrophils, MCV, MCH, MCHC and platelet

  18. 石场接尘工人肺通气功能检查结果分析%Analysis on pulmonary function test results of quarry workers exposed to dust

    Institute of Scientific and Technical Information of China (English)

    钟东明; 朱如芳; 陈真富

    2012-01-01

    Objective To investigate the pulmonary function abnormalities of quarry workers exposed to dust.Methods Epidemiological tools was used to detect and analyze 260 workers exposed to dust from 8 quarry (including FVC,FEV1,MMF,V50,V75),compared with 246 cases of regular workers without dust exposure as control.Results The pulmonary function of workers exposed to dust quarry was significantly lower than that of the control group,lung function abnormalities increased with length of service with the trend,and female workers' lung function abnormalities was higher than that of male workers.Conclusion Damage is detected to lung function of quarry workers,and there is difference in dust seniority and gender,therefore,the occupational protection should be strengthened,and health surveillance records should be implemented to dust-exposed workers.%目的 探讨石场接尘工人肺通气功能异常情况.方法 运用流行病学手段,对8间石场260例接尘工人进行肺功能测定(包括FVC、FEV1、MMF、V50、V75),并与246例无接尘正常工人做对照.结果 石场接尘工人肺通气功能显著低于对照组工人,肺通气功能异常有随着工龄增长而增加的趋势,并女工肺功能异常率高于男工.结论 石场接尘人工肺功能有损伤,并在接尘工龄、性别上有差异,因此,提倡加强职业防护,做好粉尘作业工人健康监护.

  19. Asbestosis and other pulmonary fibrosis in asbestos-exposed workers: high-resolution CT features with pathological correlations

    Energy Technology Data Exchange (ETDEWEB)

    Arakawa, Hiroaki [Dokkyo Medical University, Department of Radiology, Mibu, Tochigi (Japan); Kishimoto, Takumi [Okayama Rosai Hospital, Asbestos Research Center, Okayama (Japan); Ashizawa, Kazuto [Nagasaki University Graduate School of Biomedical Sciences, Department of Clinical Oncology, Nagasaki (Japan); Kato, Katsuya [Kawasaki Medical School, Department of Diagnostic Radiology 2, Okayama (Japan); Okamoto, Kenzo [Hokkaido Chuo Hospital, Department of Pathology, Iwamizawa, Hokkaido (Japan); Honma, Koichi [Dokkyo Medical University, Department of Pathology, Mibu, Tochigi (Japan); Hayashi, Seiji [National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka (Japan); Akira, Masanori [National Hospital Organization Kinki-Chuo Chest Medical Center, Department of Radiology, Osaka (Japan)

    2016-05-15

    The purpose was to identify distinguishing CT features of pathologically diagnosed asbestosis, and correlate diagnostic confidence with asbestos body burden. Thirty-three workers (mean age at CT: 73 years) with clinical diagnoses of asbestosis, who were autopsied (n = 30) or underwent lobectomy (n = 3), were collected. Two radiologists independently scored high-resolution CT images for various CT findings and the likelihood of asbestosis was scored. Two pathologists reviewed the pathology specimens and scored the confidence of their diagnoses. Asbestos body count was correlated with CT and pathology scores. Pathologically, 15 cases were diagnosed as asbestosis and 18 cases with various lung fibroses other than asbestosis. On CT, only the score of the subpleural curvilinear lines was significantly higher in asbestosis (p = 0.03). Accuracy of CT diagnosis of asbestosis with a high confidence ranged from 0.73 to 0.79. Asbestos body count positively correlated with CT likelihood of asbestosis (r = 0.503, p = 0.003), and with the confidence level of pathological diagnosis (r = 0.637, p < 0.001). Subpleural curvilinear lines were the only clue for the diagnosis of asbestosis. However, this was complicated by other lung fibrosis, especially at low asbestos body burden. (orig.)

  20. Asbestosis and other pulmonary fibrosis in asbestos-exposed workers: high-resolution CT features with pathological correlations

    International Nuclear Information System (INIS)

    The purpose was to identify distinguishing CT features of pathologically diagnosed asbestosis, and correlate diagnostic confidence with asbestos body burden. Thirty-three workers (mean age at CT: 73 years) with clinical diagnoses of asbestosis, who were autopsied (n = 30) or underwent lobectomy (n = 3), were collected. Two radiologists independently scored high-resolution CT images for various CT findings and the likelihood of asbestosis was scored. Two pathologists reviewed the pathology specimens and scored the confidence of their diagnoses. Asbestos body count was correlated with CT and pathology scores. Pathologically, 15 cases were diagnosed as asbestosis and 18 cases with various lung fibroses other than asbestosis. On CT, only the score of the subpleural curvilinear lines was significantly higher in asbestosis (p = 0.03). Accuracy of CT diagnosis of asbestosis with a high confidence ranged from 0.73 to 0.79. Asbestos body count positively correlated with CT likelihood of asbestosis (r = 0.503, p = 0.003), and with the confidence level of pathological diagnosis (r = 0.637, p < 0.001). Subpleural curvilinear lines were the only clue for the diagnosis of asbestosis. However, this was complicated by other lung fibrosis, especially at low asbestos body burden. (orig.)

  1. Analysis and risk estimates to workers of Brazilian granitic industries and sandblasters exposed to respirable crystalline silica and natural radionuclides

    Energy Technology Data Exchange (ETDEWEB)

    Estellita, L. [Instituto de Fisica, Universidade Federal Fluminense, Av. Gal Milton Tavares de Souza, s/n, Gragoata, 24210-340 Niteroi, RJ (Brazil); Santos, A.M.A. [Fundacao Jorge Duprat Figueiredo de Seguranca e Medicina do Trabalho, Fundacentro, C.P. 11484, 05499-970 Sao Paulo, SP (Brazil); Anjos, R.M., E-mail: meigikos@if.uff.b [Instituto de Fisica, Universidade Federal Fluminense, Av. Gal Milton Tavares de Souza, s/n, Gragoata, 24210-340 Niteroi, RJ (Brazil); Yoshimura, E.M. [Instituto de Fisica, Universidade de Sao Paulo, C.P. 66318, 05314-970 Sao Paulo, SP (Brazil); Velasco, H. [Grupo de Estudios Ambientales - IMASL. Universidad Nacional de San Luis / CONICET. Ej. de los Andes 950, D5700HHW San Luis (Argentina); Silva, A.A.R. da [Instituto de Fisica, Universidade de Sao Paulo, C.P. 66318, 05314-970 Sao Paulo, SP (Brazil); Aguiar, J.G. [Fundacao Jorge Duprat Figueiredo de Seguranca e Medicina do Trabalho, Fundacentro, C.P. 11484, 05499-970 Sao Paulo, SP (Brazil)

    2010-02-15

    Occupational exposure to respirable crystalline silica and to radiation emitted by natural radionuclides present both in rocks and sands was studied in the Brazilian extractive process and granite product manufacture. Respirable airborne dust samples were collected in working environments, where workers perform different tasks with distinct commercial granites types, and also in places where sandblasters work with sands from different origins. The free crystalline silica contents were determined using X-ray diffraction of the respirable particulate fraction of each sample. Dust samples from granite cutting and sandblasting ambient had the natural radionuclides concentrations measured by gamma spectrometry. Dust concentrations in the workplaces were quite variable, reaching values up to 10 times higher than the respirable particle mass threshold limit value (TLV) set by the American Conference for Governmental Industrial Hygienists of 3 mg m{sup -3}. Also the free crystalline silica concentrations were high, reaching values up to 48 times the TLV of 0.025 mg m{sup -3}. Additionally, our results suggest that the risk of radiation-induced cancer in the granite or marble industries is negligible. However, the combined exposure to dust, gamma radiation, and radon daughter products could result in the enhancement of lung cancer risks associated to sandblasting activities.

  2. Improved identification and enrolment into care of HIV-exposed and -infected infants and children following a community health worker intervention in Lilongwe, Malawi

    Directory of Open Access Journals (Sweden)

    Saeed Ahmed

    2015-01-01

    Full Text Available Background: Early identification and entry into care is critical to reducing morbidity and mortality in children with HIV. The objective of this report is to describe the impact of the Tingathe programme, which utilizes community health workers (CHWs to improve identification and enrolment into care of HIV-exposed and -infected infants and children. Methods: Three programme phases are described. During the first phase, Mentorship Only (MO (March 2007–February 2008 on-site clinical mentorship on paediatric HIV care was provided. In the second phase, Tingathe-Basic (March 2008–February 2009, CHWs provided HIV testing and counselling to improve case finding of HIV-exposed and -infected children. In the final phase, Tingathe-PMTCT (prevention of mother-to-child transmission (March 2009–February 2011, CHWs were also assigned to HIV-positive pregnant women to improve mother-infant retention in care. We reviewed routinely collected programme data from HIV testing registers, patient mastercards and clinic attendance registers from March 2005 to March 2011. Results: During MO, 42 children (38 HIV-infected and 4 HIV-exposed were active in care. During Tingathe-Basic, 238 HIV-infected children (HIC were newly enrolled, a six-fold increase in rate of enrolment from 3.2 to 19.8 per month. The number of HIV-exposed infants (HEI increased from 4 to 118. During Tingathe-PMTCT, 526 HIC were newly enrolled over 24 months, at a rate of 21.9 patients per month. There was also a seven-fold increase in the average number of exposed infants enrolled per month (9.5–70 patients per month, resulting in 1667 enrolled with a younger median age at enrolment (5.2 vs. 2.5 months; p<0.001.During the Tingathe-Basic and Tingathe-PMTCT periods, CHWs conducted 44,388 rapid HIV tests, 7658 (17.3% in children aged 18 months to 15 years; 351 (4.6% tested HIV-positive. Over this time, 1781 HEI were enrolled, with 102 (5.7% found HIV-infected by positive PCR. Additional HIC

  3. Abnormal vitamin K metabolism in the presence of normal clotting factor activity in factory workers exposed to 4-hydroxycoumarins.

    Science.gov (United States)

    Park, B K; Choonara, I A; Haynes, B P; Breckenridge, A M; Malia, R G; Preston, F E

    1986-03-01

    The case histories of two patients exposed to the novel anticoagulants brodifacoum and difenacoum are reported. Abnormal vitamin K1 metabolism, as indicated by elevated vitamin K1 2,3-epoxide plasma concentrations after i.v. administration of vitamin K1, could be detected for more than 18 months after exposure to the anticoagulants. There was a marked prolongation of prothrombin time (greater than 50 s) in both cases, at the time of exposure. However, subsequent haematological investigations (prothrombin time and vitamin K-dependent clotting factor activity) have been shown to be normal in both cases for at least 18 months. These cases confirm the long-acting nature of brodifacoum and difenacoum and present an apparent dissociation between the effect of coumarin anticoagulants on vitamin K1 metabolism and clotting factor activity. PMID:3964529

  4. Update: cohort mortality study of workers highly exposed to polychlorinated biphenyls (PCBs during the manufacture of electrical capacitors, 1940-1998

    Directory of Open Access Journals (Sweden)

    Whelan Elizabeth A

    2006-05-01

    Full Text Available Abstract Background The National Institute for Occupational Safety and Health previously reported mortality for a cohort of workers considered highly exposed to polychlorinated biphenyls (PCBs between 1939 and 1977 at two electrical capacitor manufacturing plants. The current study updated vital status, examined liver and rectal cancer mortality previously reported in excess in this cohort and evaluated mortality from non-Hodgkin's lymphoma (NHL and cancers of the stomach, intestine, breast, prostate, skin (melanoma and brain reported to be in excess in other cohort and case-control studies of PCB-exposed persons. Methods Mortality was updated through 1998 for 2572 workers. Age-, gender-, race- and calendar year-adjusted standardized mortality ratios (SMRs and 95% confidence intervals (CI were calculated using U.S., state and county referent rates. SMRs using U.S. referent rates are reported. Duration of employment was used as a surrogate for exposure. Results Consistent with the previous follow-up, mortality from biliary passage, liver and gall bladder cancer was significantly elevated (11 deaths, SMR 2.11, CI 1.05 – 3.77, but mortality from rectal cancer was not (6 deaths, SMR 1.47, CI 0.54 – 3.21. Among women, mortality from intestinal cancer (24 deaths, SMR 1.89, CI 1.21 – 2.82 and from "other diseases of the nervous system and sense organs", which include Parkinson's disease and amyotrophic lateral sclerosis, (15 deaths, SMR 2.07, CI 1.16 – 3.42 were elevated. There were four ALS deaths, all women (SMR 4.35, CI 1.19–11.14. Mortality was elevated for myeloma (7 deaths, SMR 2.11, CI 0.84 – 4.34, particularly among workers employed 10 years or more (5 deaths, SMR 2.80, CI 0.91 – 6.54. No linear associations between mortality and duration of employment were observed for the cancers of interest. Conclusion This update found that the earlier reported excess in this cohort for biliary, liver and gall bladder cancer persisted with

  5. Microbiological contamination of lamb carcasses at abattoirs of Istanbul

    Directory of Open Access Journals (Sweden)

    Tolga Kahraman

    2005-01-01

    Full Text Available A total of a hundred lamb carcasses were sampled over a 12 month period at abattoirs in Istanbul, Turkey. Each sample examined for total aerobic mesophilic counts (TMC, Enterobacteriaceae count (EC, Salmonella spp. Escherichia coli O157:H7 and Listeria monocytogenes was obtained from 100 cm2 areas on four sides of lamb carcasses using the wet and dry cotton swab technique. The study revealed that total aerobic mesophilic counts in all carcasses ranged between 4.18 and 5.95 log/cm2; Enterobacteriaceae counts between 1.60 and 2.30 CFU/cm2. All samples were negative for Escherichia coli O157:H7 and Listeria monocytogenes. Furthermore Salmonella spp. was detected on four carcasses. The data confirms bacteriological monitoring of lamb carcasses as a useful criteria for the verification of slaughter hygiene.

  6. Dependence of Papanicolaou gradings of exfoliated urothelial cells upon GSTM1 and GSTT1 polymorphism in benzidine-exposed workers of the Shanghai dye industry

    Energy Technology Data Exchange (ETDEWEB)

    Lin Guofang; Ma Qingwen; Shen Jianhua; Zhang Dongsheng [Shanghai Inst. of Biological Sciences, Chinese Academy of Sciences, Shanghai (China); Chen Jigang; Xiang Cuiqing [Municipal Center for Disease Prevention and Control, Shanghai (China); Golka, K. [Institute of Occupational Physiology, Univ. of Dortmund (Germany)

    2001-11-01

    The distribution of the polymorphic alleles of the genes coding for glutathione S-transferases (GSTs) M1 and T1 was compared with the results of cytological grading of exfoliated urothelial cells (Pap test) in a non-diseased high-risk group of workers formerly exposed to benzidine in the Shanghai dyestuff industry (n=317). All subjects were genotyped for GSTT1 and M1 gene polymorphism by allele-specific PCR. Individuals were stratified according to their job and duration of exposure. A subgroup of 78 individuals with cytological gradings of grade III or higher in the Pap test showed a significant under-representation of the combination of GSTT1 0/0 and M1 0/0 genotypes compared with 238 subjects with a cytological classification lower than grade III (OR 0.55, 95% CI 0.31-0.98, P=0.04). These results suggest that neither the GSTM1 0/0 or GSTT1 0/0 genotype alone nor their combination had a clear association with cytopathological changes in exfoliated urothelial cells from individuals previously exposed to benzidine in Shanghai. This contradicts the results of studies indicating that the GSTM1 0/0 genotype is associated with an increased risk for bladder cancer in the general population, mostly outside China. (orig.)

  7. Microdistribution and long-term retention of 239Pu (NO3)4 in the respiratory tracts of an acutely exposed plutonium worker and experimental beagle dogs.

    Science.gov (United States)

    Nielsen, Christopher E; Wilson, Dulaney A; Brooks, Antone L; McCord, Stacey L; Dagle, Gerald E; James, Anthony C; Tolmachev, Sergei Y; Thrall, Brian D; Morgan, William F

    2012-11-01

    The long-term retention of inhaled soluble forms of plutonium raises concerns as to the potential health effects in persons working in nuclear energy or the nuclear weapons program. The distributions of long-term retained inhaled plutonium-nitrate [(239)Pu (NO(3))(4)] deposited in the lungs of an accidentally exposed nuclear worker (Human Case 0269) and in the lungs of experimentally exposed beagle dogs with varying initial lung depositions were determined via autoradiographs of selected histologic lung, lymph node, trachea, and nasal turbinate tissue sections. These studies showed that both the human and dogs had a nonuniform distribution of plutonium throughout the lung tissue. Fibrotic scar tissue effectively encapsulated a portion of the plutonium and prevented its clearance from the body or translocation to other tissues and diminished dose to organ parenchyma. Alpha radiation activity from deposited plutonium in Human Case 0269 was observed primarily along the subpleural regions while no alpha activity was seen in the tracheobronchial lymph nodes of this individual. However, relatively high activity levels in the tracheobronchial lymph nodes of the beagles indicated the lymphatic system was effective in clearing deposited plutonium from the lung tissues. In both the human case and beagle dogs, the appearance of retained plutonium within the respiratory tract was inconsistent with current biokinetic models of clearance for soluble forms of plutonium. Bound plutonium can have a marked effect on the dose to the lungs and subsequent radiation exposure has the potential to increase cancer risk.

  8. Microdistribution and Long-Term Retention of 239Pu (NO3)4 in the Respiratory Tracts of an Acutely Exposed Plutonium Worker and Experimental Beagle Dogs

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, Christopher E.; Wilson, Dulaney A.; Brooks, Antone L.; McCord, Stacey; Dagle, Gerald E.; James, Anthony C.; Tolmachev, Sergei Y.; Thrall, Brian D.; Morgan, William F.

    2012-11-01

    The long-term retention of inhaled soluble forms of plutonium raises concerns as to the potential health effects in persons working in nuclear energy or the nuclear weapons program. The distributions of long-term retained inhaled plutonium-nitrate [239Pu (NO3)4] deposited in the lungs of an accidentally exposed nuclear worker (Human Case 0269) and in the lungs of experimentally exposed beagle dogs with varying initial lung depositions were determined via autoradiographs of selected histological lung, lymph node, trachea, and nasal turbinate tissue sections. These studies showed that both the human and dogs had a non-uniform distribution of plutonium throughout the lung tissue. Fibrotic scar tissue effectively encapsulated a portion of the plutonium and prevented its clearance from the body or translocation to other tissues and diminished dose to organ parenchyma. Alpha radiation activity from deposited plutonium in Human Case 0269 was observed primarily along the sub-pleural regions while no alpha activity was seen in the tracheobronchial lymph nodes of this individual. However, relatively high activity levels in the tracheobronchial lymph nodes of the beagles indicated the lymphatic system was effective in clearing deposited plutonium from the lung tissues. In both the human case and beagle dogs, the appearance of retained plutonium within the respiratory tract was inconsistent with current biokinetic models of clearance for soluble forms of plutonium. Bound plutonium can have a marked effect on the dose to the lungs and subsequent radiation exposure has the potential increase in cancer risk.

  9. Investigation of Sarcocystis Infection in Slaughtered Goats in Jahrom Abattoir

    Directory of Open Access Journals (Sweden)

    Zahra Kargar Jahromi

    2012-12-01

    Full Text Available Background and Objective: Sarcocyst infection is one of the most common zoonotic protozoan diseases caused by different Sarcocystis spp. Given the importance of this infection in public health, the infection rate of macroscopic and microscopic sarcocysts in slaughtered goats was determined in Jahrom abattoir. Materials and Methods : Between April and June in 2011, six tissues including the esophagus, tongue, diaphragm, shoulder muscles, thigh muscles, and heart of 4925 slaughtered goats were inspected to detect macroscopic sarcocysts in Jahrom abattoir. To detect microscopic cysts, four tissue samples (esophagus, tongue, diaphragm, and heart from 400 goats free of macroscopic cysts were investigated randomly via impression smear and digestion method. Results: The infection rate of macroscopic cysts was 9.48% and the highest infection rate was observed in the esophagus (91.1%. There was no significant relationship between the infection rate of macroscopic cysts and the age or gender (p value >0.05. The infection rate of microscopic cysts was 59.5% and 100% via impression smear and digestion method, respectively. There was a significant relationship between the infection rate of microscopic cysts and age (p value =0.002, whereas the relationship between the infection rate and age did not constitute statistical significance (p value =0.700. Conclusion: The results showed that digestion method was the most sensitive method for the detection of sarcocystis in goats and 100% of the goats were infected by this method. Thus for the prevention of human infection, the meat should be frozen or cooked sufficiently before consumption irrespective of the results of carcass inspection.

  10. Frequency of gamma H2AX foci in healthy volunteers and health workers occupationally exposed to X-irradiation and its relevance in biological dosimetry.

    Science.gov (United States)

    Raavi, Venkateswarlu; Basheerudeen, Safa Abdul Syed; Jagannathan, Vijayalakshmi; Joseph, Santosh; Chaudhury, Nabo Kumar; Venkatachalam, Perumal

    2016-08-01

    Gamma-H2AX (γ-H2AX) assay is a marker to measure double-strand breaks in the deoxyribonucleic acid. Variables such as age, oxidative stress, temperature, genetic factors and inter-individual variation have been reported to influence the baseline γ-H2AX focus levels. Therefore, knowledge on baseline frequency of γ-H2AX foci in a targeted population would facilitate reliable radiation triage and dose estimation. The objective of the present study was to establish the baseline data using blood samples from healthy volunteers (n = 130) differing in age, occupation and lifestyle as well as from occupationally exposed health workers (n = 20). The γ-H2AX focus assay was performed using epifluorescence microscopy. In vitro dose-response curve for γ-H2AX foci was constructed in blood samples (n = 3) exposed to X-rays (30 min post-exposure). The mean γ-H2AX focus frequency obtained in healthy volunteers was 0.042 ± 0.001 and showed an age-related increase (p healthy volunteers. A sub-group analysis did not show a significant (p > 0.1) difference in γ-H2AX focus frequency among sexes. Blood exposed in vitro to X-rays showed dose-dependent increase in γ-H2AX foci frequency (Y = 0.1902 ± 0.1363 + 2.9020 ± 0.3240 * D). Baseline frequency of γ-H2AX foci obtained from different age groups showed a significant (p lifestyle factors. PMID:27287768

  11. Poultry abattoir survey of carcass condemnation for standard, vegetarian, and free range chickens.

    OpenAIRE

    Herenda, D; Jakel, O

    1994-01-01

    During the period April 1991 to March 1992, data concerning the condemnation rate of standard, vegetarian, and free-range chickens were collected and summarized from one federally inspected abattoir in Ontario. The purpose of this study was to discuss the effects of diet, management, and breed of chickens on pathological lesions, ensuing condemnation rates, and consequent losses to the growers and the poultry industry. The data collected at this abattoir revealed that vegetarian chickens show...

  12. - On Investigating Pollution of Groundwater from Atenda Abattoir Wastes, Ogbomoso, Nigeria

    Directory of Open Access Journals (Sweden)

    Adewoye, Abosede Olufunmilayo

    2012-09-01

    Full Text Available The incidence of waterborne diseases arising from pollution of shallow wells in abattoir environment has been on the increase in Ogbomoso community. This project work was carried out in order to examine the geochemical constituents of water samples taken from selected wells in Atenda abattoir environment, Ogbomoso, Oyo State, Nigeria. The effect of abattoir wastes on the groundwater samples and geotechnical analyses of soil samples taken from two points around the abattoir waste dump, and another sample from a control point free from pollution and far away from where the first two samples were taken, were also carried out. Geophysical investigation of the Atenda area was carried out using Vertical Electrical Sounding (VES of Electrical Resistivity Method (ERM, Electrical Resistivity Tomography (ERT, and also, Very Low Frequency (VLF electromagnetic method. The geophysical investigation was carried out to determine the lithology of the study area, track the contaminant plume view and compute the depth to bedrock in the study area. It was observed that a strong correlation exist between leachates from the Atenda abattoir location and sampled wells in the immediate environment. A groundwater monitoring programme to determine groundwater quality status of wells in the neighbourhood of abattoirs is recommended for implementation to safeguard the health of innocent residents in the vicinity.

  13. 铅作业工人血铅水平与膳食营养素关系研究%Study on the correlation between blood lead level and dietary nutrition in lead exposed workers

    Institute of Scientific and Technical Information of China (English)

    陈榕芳; 谢克锦; 林征; 祖庆; 郑嘉华

    2015-01-01

    目的:探讨铅作业工人体内血铅水平与膳食营养素的关系。方法以福建省南平市某蓄电池厂427名铅作业工人为调查对象,采用自行设计问卷调查作业工人工龄、接铅方式和膳食情况,测定其血铅水平。结果铅作业工人血铅水平中位数为340.1μg/L,血铅水平超标率为45.9%(196/427)。铁摄入过量的铅作业工人血铅超标率高于铁摄入适宜的铅作业工人( P<0.0125);维生素B2摄入过量的铅作业工人血铅超标率高于维生素B2摄入适宜的铅作业工人( P<0.0125)。 Logistic回归分析结果显示:蛋白质摄入过量的铅作业工人发生血铅超标的风险低于蛋白质摄入适宜者(P<0.01),硒摄入不足的铅作业工人发生血铅超标的风险低于硒摄入适宜者(P<0.01);男性铅作业工人发生血铅超标的风险高于女性(P<0.01),工龄越长的铅作业工人发生血铅超标的风险越高(P<0.01),单纯接触铅尘的铅作业工人发生血铅超标的风险高于接触混合铅者(P<0.01),能量摄入不足或过量的铅作业工人发生血铅超标的风险高于能量摄入适宜者(P<0.01)。结论应建立膳食平衡、健康促进和工作环境控制的复合式干预模式。平衡铅作业工人膳食营养,增加能量和维生素B2的摄入。%Objective To explore the correlation between blood lead level and dietary nutrition in workers exposed to lead. Methods Four hundred and twenty-seven lead exposed workers were selected as the investigation objects from a battery factory in Nanping city, Fujian province.By self-designed questionnaire, the workers were investigated on the length of service, lead exposure types and dietary situation status, to determine their blood lead levels.Results The median blood lead level of lead exposed workers was 340.1μg/L, and the over standard rate of blood lead was 45.9%(196/427) .The

  14. Role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides.

    Science.gov (United States)

    Singh, Satyender; Kumar, Vivek; Vashisht, Kapil; Singh, Priyanka; Banerjee, Basu Dev; Rautela, Rajender Singh; Grover, Shyam Sunder; Rawat, Devendra Singh; Pasha, Syed Tazeen; Jain, Sudhir Kumar; Rai, Arvind

    2011-11-15

    Organophosphate pesticides (OPs) are primarily metabolized by several xenobiotic metabolizing enzymes (XMEs). Very few studies have explored genetic polymorphisms of XMEs and their association with DNA damage in pesticide-exposed workers. The present study was designed to determine the role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to OPs. We examined 284 subjects including 150 workers occupationally exposed to OPs and 134 normal healthy controls. The DNA damage was evaluated using the alkaline comet assay and genotyping was done using PCR-RFLP. The results revealed that the PONase activity toward paraoxonase and AChE activity was found significantly lowered in workers as compared to control subjects (p<0.001). Workers showed significantly higher DNA damage compared to control subjects (14.37±2.15 vs. 6.24±1.37 tail% DNA, p<0.001). Further, the workers with CYP2D6*3PM and PON1 (QQ and MM) genotypes were found to have significantly higher DNA damage when compared to other genotypes (p<0.05). In addition, significant increase in DNA damage was also observed in workers with concomitant presence of certain CYP2D6 and PON1 (Q192R and L55M) genotypes which need further extensive studies. In conclusion, the results indicate that the PON1 and CYP2D6 genotypes can modulate DNA damage elicited by some OPs possibly through gene-environment interactions.

  15. Avaliação audiológica em trabalhadores expostos a ruído e praguicida Audiological evaluation in workers exposed to noise and pesticide

    Directory of Open Access Journals (Sweden)

    Heraldo Lorena Guida

    2010-08-01

    Full Text Available A perda auditiva induzida por ruído é estudada há muitos anos, e atualmente a literatura especializada estuda também a ação sinérgica dos produtos químicos, uma vez que eles podem ser potencialmente ototóxicos. OBJETIVO: Pesquisar os achados audiológicos em trabalhadores expostos ao ruído ocupacional e a praguicidas e comparar com os dados obtidos em trabalhadores expostos ao ruído. FORMA DE ESTUDO: Clínico retrospectivo. MATERIAL E MÉTODO: Foram analisados os prontuários de indivíduos que foram expostos ao praguicida e ao ruído (grupo I, e indivíduos que foram somente expostos ao ruído (grupo II. RESULTADOS: A classificação dos achados audiométricos revelou para o grupo I: 35% orelhas normais, 53,75% com perda auditiva de grau 1 e 11,25% com perda de grau 2. Enquanto que o grupo II apresentou 57,5% de orelhas normais, 40% com perda auditiva de grau 1 e apenas 2,5% com perda de grau 2. A análise dos achados audiométricos demonstrou também uma piora significativa após a comparação entre os limiares do grupo I e grupo II, na frequência de 3 kHz orelha esquerda e na frequência de 4kHz em ambas as orelhas. CONCLUSÃO: A análise mostrou que o grupo I tem limiares audiométricos piores comparado ao grupo II.Noise-induced hearing loss has been studied for many years and today many experts also investigate the synergic action of chemical products, since they can be potentially ototoxic. AIM: to investigate the audiological findings in workers exposed to occupational noise and pesticide and to compare it to data from noise-exposed workers. STUDY DESIGN: Clinical retrospective. MATERIAL AND METHOD: individuals that had been exposed to pesticide and noise (group I, and individuals that had been exposed to noise only (group II. RESULTS: The classification of the audiometric findings showed in that group I: 35% had normal hearing thresholds, 53.75% had degree 1 hearing loss and 11.25% had degree 2 hearing loss; and group II had

  16. French government regulation - new enactment on optimised radiation protection of workers exposed to ionizing radiation - implementation at a French nuclear power plant belonging to the EDF Group

    International Nuclear Information System (INIS)

    The radiation protection system defined by ICRP 60 and included in European Directive no. 96/29 is based on the three general principles of radiation protection: the justification of practices, the optimisation of radiation protection and the limitation of individual exposures. Since 1988, French law requires for nuclear power plant an optimisation approach (ALARA) in the case of maintenance activities (equipment, methods and work organisation) relying on a specific structure: the department with special responsibility for radiation protection. Recently, in December 1998, this general principle of optimisation was enhanced by the obligation to take a predictive approach in order to implement it. For all operations carried out in Radiation Controlled Areas (RCA), the law requires a prior estimation of individual and collective doses to which workers might be exposed, followed by the measurement and analysis of radiation doses actually absorbed during the activity. With a view to consistent implementation on all its plants, EDF has drawn up a set of specific reference guidelines. These guidelines define the activity and describe a procedure for carrying out individual and collective dose forecasts for each activity. They also include a set of activity grading criteria based on the activity's radiological risk factor, a procedure for dealing with each level of risk, and a procedure for monitoring operational radiation exposure. They deploy the three phases of the ALARA approach: planning, implementation and experience feedback. (author)

  17. Assessment of Some Immune Parameters in Occupationally Exposed Nuclear Power Plants Workers: Flowcytometry Measurements of T, B, NK and NKT Cells.

    Science.gov (United States)

    Gyuleva, Ilona; Panova, Delyana; Djounova, Jana; Rupova, Ivanka; Penkova, Kalina

    2015-01-01

    The purpose of this article is to analyze the results of a 10-year survey of the radiation effects of some immune parameters of occupationally exposed personnel from the Nuclear Power Plant "Kozloduy", Bulgaria. 438 persons working in NPP with cumulative doses between 0.06 mSv and 766.36mSv and a control group with 65 persons were studied. Flow cytometry measurements of T, B, natural killer (NK) and natural killer T (NKT) cell lymphocyte populations were performed. Data were interpreted with regard to cumulative doses, length of service and age. The average values of the studied parameters of cellular immunity were in the reference range relative to age and for most of the workers were not significantly different from the control values. Low doses of ionizing radiation showed some trends of change in the number of CD3+CD4+ helper-inducer lymphocytes, CD3+ CD8+ and NKT cell counts. The observed changes in some of the studied parameters could be interpreted in terms of adaptation processes at low doses. At doses above 100-200 mSv, compensatory mechanisms might be involved to balance deviations in lymphocyte subsets. The observed variations in some cases could not be attributed only to the radiation exposure because of the impact of a number of other exogenous and endogenous factors on the immune system. PMID:26675014

  18. Características do zumbido em trabalhadores expostos a ruído The characteristics of tinnitus in workers exposed to noise

    Directory of Open Access Journals (Sweden)

    Luciara Giacobe Steinmetz

    2009-02-01

    Full Text Available O zumbido é um sintoma auditivo relatado por indivíduos expostos ao ruído. OBJETIVO: Estudar as características do zumbido relatadas por indivíduos expostos ao ruído ocupacional. FORMA DE ESTUDO: Descritivo prospectivo. MATERIAL E MÉTODO: Participaram 52 indivíduos com idade média de 29 anos que faziam parte do programa de prevenção da perda auditiva de um frigorífico. Os indivíduos responderam a uma anamnese e suas audiometrias realizadas em 2005 e 2006 foram utilizadas. RESULTADOS: No presente estudo, 71% dos indivíduos apresentaram audiometria normal. A prevalência do zumbido para o sexo masculino foi de 16% e para o sexo feminino foi de 9% apresentando tempo médio de exposição ao ruído de sete anos a um nível médio de ruído entre 86 e 91 dBA (48%. Verificou-se um predomínio do zumbido bilateral (46%, do tipo chiado (40% de intensidade média (49%, com tempo de instalação do sintoma entre um a cinco anos (67%, sendo sua freqüência semanal (41% e a noite o período que mais perturba (34%. Encontrou-se significância entre a periodicidade do zumbido e o nível de ruído. CONCLUSÃO: Recomenda-se a inclusão do tema zumbido em programas de prevenção da perda auditiva a fim de promover a saúde auditiva dos trabalhadores.Tinnitus is a common auditory complaint among individuals exposed to noise. AIM: this paper aims to study the characteristics of tinnitus in workers exposed to noise. STUDY DESIGN: this is a descriptive prospective study. MATERIALS AND METHOD: Fifty-two individuals averaging 29 years of age were enrolled in a hearing loss prevention program at a meat processing plant. The participants were interviewed and had their hearing tested in 2005 and 2006. RESULTS: seventy-one percent of the participants were found to have normal hearing. Tinnitus was present in 16% of the males and in 9% of the females. Mean noise exposure length was 7 years and noise levels ranged from 86 to 91 dBA (48%. Bilateral tinnitus

  19. Investigation on dermal contamination among workers occupationally exposed to dimethylformamide%二甲基甲酰胺作业工人皮肤污染量研究

    Institute of Scientific and Technical Information of China (English)

    刘丹华; 唐红芳; 徐承敏; 柴剑荣; 吴昊; 李文琛; 钱亚玲

    2010-01-01

    Objective To establish a method for the determination of dimethylformamide(DMF) and investigate dermal contamination and absorption among workers occupationally exposed to DMF. Method 37 workers exposed to DMF were divided randomly into two groups. DMF was washed down by isopropyl alcohol in A group (16 workers) and water in B group(21 workers).Gas chromatography was used for the quantification of dermal contamination and N-methylformamide(NMF) in urine, correlative study was done between them. Results DMF could be detected in all samples in A group, but could not be detected in B group. The miscel-laneous peaks could be completely separated from the DMF peak in the sample spectrum, without matual in-ference. The highest degree of total dermal contamination was observed in wet spinning workshop[(2.84±1.31 ) ing], postprocessing workshop[(2.50±0.95) mg] and dry spinning workshop[( 1.95±0.61) mg] were lower. The respiratory cumulative exposure dosages were 351.3, 201.3 and 135.2 mg respectively. The average DMP concentration in air of the third printing processing workshop, the dry spirning workshop and the wet spinning workshop was 60.2, 89.6, 156.4 mg/m3 respectively, and the respiratory tract contamination in the workers of the three workshops were 135.2, 201.3 and 351.3 mg respectively. There was statistical independence between the quantification of total dermal contamination and NMF in urine (r=0.176,P>0.05). Conclusion Isopropyl alcohol is the effective washing solvent.When the concentration of DMF in workplace air is above the occupa-tional exposure limit, respiratory tract absorption is the principal pathway of DMF absorption,but dermal con-tamination of DMF should not be ignored.%目的 建立二甲基甲酰胺(DMF)接触工人皮肤污染量的测定方法,并对DMF接触工人皮肤污染情况进行研究.方法 选择不同岗位的37名DMF接触工人,随机分成异丙醇组(16人)和去离子水组(21人),分别以异丙醇和去离子水为擦

  20. Role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Satyender [Division of Biochemistry and Biotechnology, National Centre for Disease Control 22, Sham Nath Marg, Delhi-110054 (India); Kumar, Vivek [Environmental Biochemistry and Molecular Biology laboratory, Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Dilshad Garden, Delhi-110095 (India); Vashisht, Kapil; Singh, Priyanka [Division of Biochemistry and Biotechnology, National Centre for Disease Control 22, Sham Nath Marg, Delhi-110054 (India); Banerjee, Basu Dev, E-mail: banerjeebd@hotmail.com [Environmental Biochemistry and Molecular Biology laboratory, Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Dilshad Garden, Delhi-110095 (India); Rautela, Rajender Singh; Grover, Shyam Sunder; Rawat, Devendra Singh; Pasha, Syed Tazeen [Division of Biochemistry and Biotechnology, National Centre for Disease Control 22, Sham Nath Marg, Delhi-110054 (India); Jain, Sudhir Kumar [Centre for Epidemiology and Parasitic Diseases, National Centre for Disease Control 22, Sham Nath Marg, Delhi-110054 (India); Rai, Arvind [Division of Biochemistry and Biotechnology, National Centre for Disease Control 22, Sham Nath Marg, Delhi-110054 (India)

    2011-11-15

    Organophosphate pesticides (OPs) are primarily metabolized by several xenobiotic metabolizing enzymes (XMEs). Very few studies have explored genetic polymorphisms of XMEs and their association with DNA damage in pesticide-exposed workers. The present study was designed to determine the role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to OPs. We examined 284 subjects including 150 workers occupationally exposed to OPs and 134 normal healthy controls. The DNA damage was evaluated using the alkaline comet assay and genotyping was done using PCR-RFLP. The results revealed that the PONase activity toward paraoxonase and AChE activity was found significantly lowered in workers as compared to control subjects (p < 0.001). Workers showed significantly higher DNA damage compared to control subjects (14.37 {+-} 2.15 vs. 6.24 {+-} 1.37 tail% DNA, p < 0.001). Further, the workers with CYP2D6*3 PM and PON1 (QQ and MM) genotypes were found to have significantly higher DNA damage when compared to other genotypes (p < 0.05). In addition, significant increase in DNA damage was also observed in workers with concomitant presence of certain CYP2D6 and PON1 (Q192R and L55M) genotypes which need further extensive studies. In conclusion, the results indicate that the PON1 and CYP2D6 genotypes can modulate DNA damage elicited by some OPs possibly through gene-environment interactions. -- Highlights: Black-Right-Pointing-Pointer Role of CYP1A1, CYP3A5, CYP2C, CYP2D6 and PON1 genotypes on DNA damage. Black-Right-Pointing-Pointer Workers exposed to some OPs demonstrated increased DNA damage. Black-Right-Pointing-Pointer CYP2D6 *3 PM and PON1 (Q192R and L55M) genotypes are associated with DNA damage. Black-Right-Pointing-Pointer Concomitant presence of certain CYP2D6 and PON1 genotypes can increase DNA damage.

  1. Modulation of DNA repair capacity and mRNA expression levels of XRCC1, hOGG1 and XPC genes in styrene-exposed workers

    International Nuclear Information System (INIS)

    Decreased levels of single-strand breaks in DNA (SSBs), reflecting DNA damage, have previously been observed with increased styrene exposure in contrast to a dose-dependent increase in the base-excision repair capacity. To clarify further the above aspects, we have investigated the associations between SSBs, micronuclei, DNA repair capacity and mRNA expression in XRCC1, hOGG1 and XPC genes on 71 styrene-exposed and 51 control individuals. Styrene concentrations at workplace and in blood characterized occupational exposure. The workers were divided into low (below 50 mg/m3) and high (above 50 mg/m3) styrene exposure groups. DNA damage and DNA repair capacity were analyzed in peripheral blood lymphocytes by Comet assay. The mRNA expression levels were determined by qPCR. A significant negative correlation was observed between SSBs and styrene concentration at workplace (R = - 0.38, p = 0.001); SSBs were also significantly higher in men (p = 0.001). The capacity to repair irradiation-induced DNA damage was the highest in the low exposure group (1.34 ± 1.00 SSB/109 Da), followed by high exposure group (0.72 ± 0.81 SSB/109 Da) and controls (0.65 ± 0.82 SSB/109 Da). The mRNA expression levels of XRCC1, hOGG1 and XPC negatively correlated with styrene concentrations in blood and at workplace (p < 0.001) and positively with SSBs (p < 0.001). Micronuclei were not affected by styrene exposure, but were higher in older persons and in women (p < 0.001). In this study, we did not confirm previous findings on an increased DNA repair response to styrene-induced genotoxicity. However, negative correlations of SSBs and mRNA expression levels of XRCC1, hOGG1 and XPC with styrene exposure warrant further highly-targeted study.

  2. Blood B Lymphocyte Stimulator (BLyS)/BAFF levels may reflect natural immunity to HIV in highly exposed uninfected Beninese Commercial Sex Workers

    Science.gov (United States)

    Sabourin-Poirier, Catherine; Fourcade, Lyvia; Chagnon-Choquet, Josiane; Labbé, Annie-Claude; Alary, Michel; Guédou, Fernand; Poudrier, Johanne; Roger, Michel

    2016-01-01

    We have previously shown that excess B lymphocyte Stimulator (BLyS)/BAFF in plasma and on surface of blood dendritic cells (DC) of HIV-infected progressors coincides with B-cell dysregulations and increased frequencies of “precursor” innate marginal zone (MZ)-like B-cells. In contrast, both blood BLyS levels and frequencies of this population remained unaltered in HIV elite-controllers. Based on these observations, we hypothesized that control of BLyS and innate B-cell status could be associated with natural immunity against HIV infection. Therefore, we assessed blood BLyS levels and B-cell status in HIV highly-exposed commercial sex workers (CSWs) from Benin. We found blood BLyS levels of HIV-uninfected CSWs were lower than those observed in both HIV-infected CSW and HIV-uninfected non-CSW groups. Furthermore, levels of BLyS expression on blood T-cells and monocytes were lower in HIV-uninfected CSWs when compared to HIV-infected CSWs, but higher than those observed for HIV-uninfected non-CSWs. Concomitantly, HIV-infected CSWs presented a dysregulated blood B-cell compartment, characterized by increased total IgG1, increased frequencies of populations presenting immature and/or innate profiles and a higher ratio of IgG+/IgA+ plasmablasts. In contrast, relatively low levels of BLyS in the blood of HIV-uninfected CSWs coincided with a rather preserved B-cell compartment. PMID:27561453

  3. Blood B Lymphocyte Stimulator (BLyS)/BAFF levels may reflect natural immunity to HIV in highly exposed uninfected Beninese Commercial Sex Workers.

    Science.gov (United States)

    Sabourin-Poirier, Catherine; Fourcade, Lyvia; Chagnon-Choquet, Josiane; Labbé, Annie-Claude; Alary, Michel; Guédou, Fernand; Poudrier, Johanne; Roger, Michel

    2016-01-01

    We have previously shown that excess B lymphocyte Stimulator (BLyS)/BAFF in plasma and on surface of blood dendritic cells (DC) of HIV-infected progressors coincides with B-cell dysregulations and increased frequencies of "precursor" innate marginal zone (MZ)-like B-cells. In contrast, both blood BLyS levels and frequencies of this population remained unaltered in HIV elite-controllers. Based on these observations, we hypothesized that control of BLyS and innate B-cell status could be associated with natural immunity against HIV infection. Therefore, we assessed blood BLyS levels and B-cell status in HIV highly-exposed commercial sex workers (CSWs) from Benin. We found blood BLyS levels of HIV-uninfected CSWs were lower than those observed in both HIV-infected CSW and HIV-uninfected non-CSW groups. Furthermore, levels of BLyS expression on blood T-cells and monocytes were lower in HIV-uninfected CSWs when compared to HIV-infected CSWs, but higher than those observed for HIV-uninfected non-CSWs. Concomitantly, HIV-infected CSWs presented a dysregulated blood B-cell compartment, characterized by increased total IgG1, increased frequencies of populations presenting immature and/or innate profiles and a higher ratio of IgG(+)/IgA(+) plasmablasts. In contrast, relatively low levels of BLyS in the blood of HIV-uninfected CSWs coincided with a rather preserved B-cell compartment. PMID:27561453

  4. Risk of Lung Cancer in Workers Exposed to Benzidine and/or Beta-Naphthylamine: A Systematic Review and Meta-Analysis

    Science.gov (United States)

    Tomioka, Kimiko; Saeki, Keigo; Obayashi, Kenji; Kurumatani, Norio

    2016-01-01

    Benzidine (BZ) and beta-naphthylamine (BNA) have been classified as definite human carcinogens for bladder cancer by the International Agency for Research on Cancer. However, the epidemiological evidence for an association between exposure to BZ and/or BNA and lung cancer has been inconclusive. We conducted a systematic review and meta-analysis to determine the risk for lung cancer among workers exposed to BZ/BNA. A systematic literature search was conducted to identify studies that had reported occupational BZ/BNA exposure and the outcome of interest (lung cancer death and/or incidence). Meta-analyses were performed using random effects models to combine standardized mortality ratios (SMRs) or standardized incidence ratios (SIRs). We identified 23 retrospective cohort studies including 1745 cases of lung cancer; only one study reported smoking-adjusted lung cancer risk. A significantly increased lung cancer risk (pooled SMR/SIR 1.28; 95% CI, 1.14–1.43) was observed by combining all studies, with significant heterogeneity among studies (I2 = 64.1%, P cancer with SMR/SIR ≥4.7 (pooled SMR/SIR 1.68; 95% CI, 1.35–2.09). Effect estimates were similar for studies with and without concomitant occupational exposure to chromium, asbestos, arsenic, or bis(chloromethyl) ether. The cumulative meta-analysis showed that the evidence of association between occupational BZ/BNA exposure and lung cancer has been stable since 1995. Although the results of this meta-analysis have the potential for confounding by smoking and heterogeneity, our findings suggest that a finding of lung cancer following occupational BZ/BNA exposure should be considered to be a potential occupational disease. PMID:26947956

  5. Approach to derive doses for case-control studies of lung cancer and leukaemia among workers internally exposed to uranium and plutonium

    International Nuclear Information System (INIS)

    Case-control studies are currently conducted in 3 European countries (Belgium, France and the United Kingdom) to estimate the risk of lung cancer and leukaemia in relation to internal exposure to uranium and plutonium amongst workers in the nuclear industry. The project requires calculating doses absorbed by the lung and the bone marrow for many hundreds of cases and controls internally exposed. In order to establish a common approach to dose reconstruction, a detailed dosimetry protocol and a database of individual exposure were set up and will be presented. The dose reconstruction relies heavily on bioassay data, which are usually urine analysis, extending back over 50 years in some cases. Inevitably, data obtained over such a time span are of variable quality. It is important to review the monitoring practices at the various laboratories and to assess the reliability of these data in order to estimate possible biases as well as random uncertainties. Another key step in the reconstruction process is to decide upon the likely intake regimes consistent with the data. Generally, chronic intakes will be assumed and acute intakes will be added only when their existence is supported by operational data. Biokinetic models are used both to calculate intakes from bioassay data and to convert intakes to doses. The ICRP publication 66 respiratory tract model will be used along with the latest systemic models described by ICRP. These will be supplemented by the Leggett 2005 model for plutonium. These various models will be implemented by the code IMBA-Expert. Since it is essential to obtain central estimates for the doses, a particular problem is encountered with datasets consisting only of values below the limit of detection. For these cases Bayesian statistics will be employed using a non-informative prior probability distribution. (author)

  6. 铅作业工人血清NO水平检测研究%Detection of seurm NO level in workers exposed to lead

    Institute of Scientific and Technical Information of China (English)

    陈小玉; 王新朝; 李志远; 马玉英; 张巧

    2001-01-01

    Objective In order to explore the relationship between the serum NO level and laed intoxication. Methods The contents of serum NO and blood lead in 30 battery workers exposed to lead and in 33 controls without lead exposure were studied. The blood was determined using differential potentiometriic stripping analysis (DPSA). The level of NO was determined using nitrate reductase. Results The content of serum NO was remarkably higher in lead exposure group than that in control group (P<0.05). No difference of NO content was found in different work-age groups. Also, no linear correlation could be shown between content of serum NO and blood lead, and urinary or δ-ALA. Conclusion The serum NO might play certain role in lead intoxication but need further study.%目的 探讨NO与铅的毒作用之间的关系。方法 某个体蓄电池厂30名铅作业工人为研究对象,以33名非铅接触者为对照组,以微分电位溶出法测定血铅;以硝酸还原酶法测定血清NO含量。结果 铅接触组血清NO含量高于对照组(P<0.05)。但不同工龄组间血清NO含量无显著性差异(P>0.05)。血清NO含量与血铅浓度及尿δ-ALA含量无直线相关关系(P>0.05)。结论 一氧化氮在铅毒作用机制中可能有一定的意义。

  7. 高温作业对工人心电图影响的Meta分析%ECG Changes in Workers Exposed to High-Temperature:A Meta-analysis

    Institute of Scientific and Technical Information of China (English)

    黄鲁众; 杨腾飞; 黄晶晶; 阿克力白克·阿满吐尔; 李光; 关雪莱

    2011-01-01

    目的 采用Meta分析方法对高温作业所致工人心电图异常改变进行系统评价.方法 计算机检索中周知网CNKI全文数据库、维普数据库、万方数据库和中国生物医学文献数据库,查找1990年至2009年5月公开发表的研究高温作业和心电图异常关系的回顾性队列研究.按照纳入与排除标准选择文献、评价质量和提取数据,而后采用RevMan 4.2.2软件进行Meta分析.结果 共纳入20个研究.Meta分析结果显示,高温组心电图异常率明显高于对照组,其差异有统计学意义[OR=2.76,95%CI(2.37,3.20),P<0.00001].高温作业对工人心电图的左室高电压[OR=3.49,95%CI(2.83,4.31),P<0.00001]、窦性心律过缓[OR=2.83,95%CI(2.33,3.43),P<0.00001]、ST-T段改变[OR=2.63,95%CI(1.48,4.68),P=0.00010]有显著影响,说明左室高电压、窦性心律过速、窦性心律过缓、ST-T段改变等异常心电图改变是监测高温工作人员心血管疾病的敏感指标.结论 高温作业会使工人的心电图异常率显著高于对照组,应加强对高温作业工人的健康监测和劳动保护.%Objective To conduct a systematic review on the Electrocardiogram (ECG) changes in the workers exposed to high temperatures by means of meta-analysis. Methods The retrospective cohort studies on the relationship between high temperature and ECG abnormalities published from 1990 to May 2009 were searched in CNKI, VIP, WanFang database and CBM database. The literatures meeting the inclusive criteria were selected, the quality was assessed, the data were extracted, and the meta-analyses were conducted with RevMan 4.2.2 software. Results A total of 20 studies were included. The results of meta-analyses showed: the ECG abnormality rate of the high-temperature group was obviously superior to that of the control group with significant difference (OR=2.76, 95%CI 2.37 to 3.20, P<0.000 01 ). The high-temperature severely affected left ventricular hypertrophy (OR=3

  8. Pain and Prejudice: Does Collecting Information From the Standpoint of Exposed Workers Improve Scientific Examination of Work-Related Musculoskeletal Disorders?

    Science.gov (United States)

    Messing, Karen

    2016-07-01

    The meaning, feasibility, and importance of scientific objectivity have been debated among public health scientists. The debate is particularly relevant to occupational health, because of frequent opposition between employer and worker interests. This article suggests that the concept of standpoint (J. Eakin) may be more useful than that of objectivity in framing discussion of work-related musculoskeletal disorders. Studies done from a "worker" standpoint can, for example, investigate and characterize environmental risk factors for work-related musculoskeletal disorders, while studies from an "employer" standpoint may concentrate on identifying individual workers likely to report work-related musculoskeletal disorders or those for whom consequences of work-related musculoskeletal disorders are more severe. Within "worker" standpoints, a distinction between "high-prestige worker" and "lower-prestige worker" standpoints can be identified in the current scientific debate about the health costs and benefits of prolonged standing vs prolonged sitting at work. Contact with workers, particularly lower-prestige workers, is critical to developing and sustaining a worker-based standpoint among researchers in occupational health. This contact can be facilitated by formal collaborations between universities and unions or other community groups. PMID:26272913

  9. Influenza A virus infection of healthy piglets in an abattoir in Brazil: animal-human interface and risk for interspecies transmission

    Directory of Open Access Journals (Sweden)

    Ariane Ribeiro Amorim

    2013-08-01

    Full Text Available Asymptomatic influenza virus infections in pigs are frequent and the lack of measures for controlling viral spread facilitates the circulation of different virus strains between pigs. The goal of this study was to demonstrate the circulation of influenza A virus strains among asymptomatic piglets in an abattoir in Brazil and discuss the potential public health impacts. Tracheal samples (n = 330 were collected from asymptomatic animals by a veterinarian that also performed visual lung tissue examinations. No slaughtered animals presented with any noticeable macroscopic signs of influenza infection following examination of lung tissues. Samples were then analysed by reverse transcription-polymerase chain reaction that resulted in the identification of 30 (9% influenza A positive samples. The presence of asymptomatic pig infections suggested that these animals could facilitate virus dissemination and act as a source of infection for the herd, thereby enabling the emergence of influenza outbreaks associated with significant economic losses. Furthermore, the continuous exposure of the farm and abattoir workers to the virus increases the risk for interspecies transmission. Monitoring measures of swine influenza virus infections and vaccination and monitoring of employees for influenza infection should also be considered. In addition regulatory agencies should consider the public health ramifications regarding the potential zoonotic viral transmission between humans and pigs.

  10. Determination of eye lens doses and identification of risk groups among radiation exposed workers. An Austrian pilot study; Bestimmung der Augenlinsen-Dosis und Identifizierung von Risikogruppen bei beruflich strahlenexponierten Personen. Eine Pilotstudie in Oesterreich

    Energy Technology Data Exchange (ETDEWEB)

    Stadtmann, H.; Hranitzky, C.; Willer, H. [Seibersdorf Labor GmbH, Seibersdorf (Austria). Radiation Protection Dosimetry; Strebl, F.; Ernst, G. [Seibersdorf Labor GmbH, Seibersdorf (Austria). Radiation Safety and Applications; Aspek, W. [Allgemeine Unfallversicherungsanstalt (AUVA), Wien (Austria). Abt. Unfallverhuetung und Berufskrankheitenbekaempfung (HUB)

    2015-07-01

    On European level, in 2014 the dose limit for the lens of the eye of radiation exposed workers has been reduced from 150 to 20 mSv per year (2013/59/Euratom). Data about eye lens exposition measured under realistic operational conditions of Austrian radiation exposed workers is sparse and there is no information to verify, if all professional groups identified to be at risk for elevated eye doses will remain below the new annual dose limit. Therefore, financed by the Austrian Workers Compensation Board, AUVA, a pilot study has been initiated to answer this question. Based on published information professional groups of radiation exposed workers and operational tasks with an enhanced risk of elevated eye lens doses have been identified. By dosimetric measurements with volunteers (forehead dose meters and parallel measurements with whole-body TL-dose meters above and under the lead apron) realistic lens doses will be estimated during selected radiation exposed tasks. Comparison of yielded doses will show whether a TLD outside the apron could serve as an alternative to forehead dose meters dedicated to measure eye lens doses. Measurements with leaded protective eyewear based on IEC61331 yield results for lead equivalent in good agreement with manufacturers' information. Results for eye lens doses determined by use of a RANDO head phantom and a standardized phantom simulating a body in a typical exposition situation for interventional radiologists show that wearing of leaded goggles allows for a 90% dose reduction. Under such conditions the eye lens dose is dominated by backscatter and stray radiation from the operator's head and patient body. This has to be considered for the evaluation of protective effectiveness for leaded eye wear.

  11. Listeria monocytogenes in poultry and poultry products: Epidemiological investigations in seven Danish abattoirs

    DEFF Research Database (Denmark)

    Ojeniyi, B.; Wegener, Henrik Caspar; Jensen, N.E.;

    1996-01-01

    abattoirs including poultry processing line samples, and final products were also examined for L. monocytogenes. Listeria monocytogenes was isolated in 0 . 3% to 18 . 7% of the samples collected in the different abattoirs. Epidemiological typing of 247 L. monocytogenes isolates, including serotyping, phage...... typing, pulsed-field gel electrophoresis and ribotyping revealed 62 different clones. Based upon typability and discriminatory power, DNA typing methods used were found equally suitable as epidemiological markers. Serotyping and phage typing were not found useful as epidemiological markers for poultry...

  12. Bovine tuberculosis: prevalence and diagnostic efficacy of routine meat inspection procedure in Woldiya municipality abattoir north Wollo zone, Ethiopia.

    Science.gov (United States)

    Aylate, Alemu; Shah, Shahid Nazir; Aleme, Haileluel; Gizaw, Tarkegn Tintagu

    2013-03-01

    Bovine tuberculosis (BTB) is a widespread and endemic disease of cattle in Ethiopia posing a significant threat to public health. Regular surveillance by skin test, bacteriology, and molecular methods is not feasible due to lack of resources. Thus, routine abattoir (RA) inspection will continue to play a key role for national surveillance. A cross-sectional study was conducted at Woldiya municipal abattoir from April 1, 2009 to April 5, 2010 to estimate the prevalence of BTB in slaughtered cattle on the basis of detailed abattoir inspection and to compare efficacy of RA inspection with respect to detailed abattoir inspection and isolation and identification of Mycobacterium. Diagnostic accuracies (with corresponding measures of statistical uncertainty) were determined by computing test property statistics (sensitivity and specificity). Agreement between RA and detailed abattoir inspections was measured using kappa statistics. Out of 1,029 slaughtered heads of cattle examined during the study period, 63 (6.12 %) and 15 (1.45 %) were diagnosed with gross tuberculous lesions by detailed abattoir meat inspections and RA meat inspections, respectively, making a prevalence of 6.12 % (95 % CI: 5.2-7.1) on the basis of detailed abattoir inspection. About 59.45 % of tuberculous lesions were observed in the lungs and associated lymph nodes, whereas 35.13 % lesions were from the lymph nodes of the head. From 63 cattle suspected with tuberculosis (TB) based on detailed abattoir meat inspection, nine (19.05 %) were identified as Mycobacterium bovis, while three (4.8 %) as Mycobacterium tuberculosis. The sensitivity of RA meat inspection was 23.8 % in comparison to the detailed abattoir meat inspection and 25 % in comparison to culture, respectively. Poor agreement (k = 0.37) was seen between RA meat examination and detailed abattoir meat examination methods. Similarly, poor agreement (k = 0.013) was seen between RA meat examination and culture results. In

  13. Analysis on Pure Tone Audiometry of Workers Exposed to Noise in A Civil Airport%某民用飞机场接触噪声作业工人纯音听阈测试分析

    Institute of Scientific and Technical Information of China (English)

    陆强

    2011-01-01

    目的 探讨生产性噪声对作业工人听力的影响.方法 测定各噪声作业车间的噪声强度,对808名噪声作业人员进行纯音听阈测试,并对听力损失与工龄、工种的关系分别进行统计学分析.结果 4 000 Hz高频听阈听力损失人数最多;随着工龄的增加,听力损失检出率亦增加,不同工龄组间听力损失比较,差异有统计学意义(P<0.01),不同工种组间听力损失比较,差异无统计学意义(P>0.05).结论 噪声作业环境对作业工人高频听阈听力影响显著,随着噪声作业工龄的增加,听力损失检出率增加,建议加强个人防护,建立健康监护档案,控制职业性噪声聋发生.%[ Objective] To investigate the effect of noise on workers with occupational exposure. [ Methods] The noise intensity was measured in noise exposed workshops, 808 noise exposed workers were tested in terms of the pure tone audibility threshold, and the statistical analysis was carried out to identify the correlation between hearing loss and service length/type of work. [ Results ] There was the largest number of workers who suffered from hearing loss of 4 000 Hz high frequency audibility threshold; The heating loss detected rate rose along with the increase of service length , The hearing loss was significantly different between groups with different service length ( P <0.01). The hearing loss was not significantly different between worker of different type of work ( P > 0.05 ). [ Conclusion ] The noise exposed workers' high frequency audibility threshold is evidently influenced by the noise exposed working conditions. The hearing loss detected rate rises along with the increase of noise exposed length. It is recommended to strengthen self- protection and establish a health monitoring and protection record to avoid hearing loss induced by occupational noise.

  14. Elevated Levels of Urinary 8-Hydroxy-2′-deoxyguanosine, Lymphocytic Micronuclei, and Serum Glutathione S-Transferase in Workers Exposed to Coke Oven Emissions

    OpenAIRE

    Liu, Ai-Lin; Lu, Wen-Qing; Wang, Zeng-Zhen; Chen, Wei-Hong; Lu, Wen-Hong; Yuan, Jing; Nan, Pei-Hong; Sun, Jian-Ya; Zou, Ya-Lin; Zhou, Li-Hong; Zhang, Chi; Wu, Tang-chun

    2005-01-01

    To investigate associations among occupational exposure to coke oven emissions (COEs), oxidative stress, cytogenotoxic effects, change in the metabolizing enzyme glutathione S-transferase (GST), and internal levels of polycyclic aromatic hydrocarbons (PAHs) in coke oven workers, we recruited 47 male coke oven workers and 31 male control subjects from a coke oven plant in northern China. We measured the levels of 1-hydroxypyrene (1-OHP) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine, micron...

  15. Factors influencing Salmonella carcass prevalence in Danish pig abattoirs

    DEFF Research Database (Denmark)

    Freitas de Matos Baptista, Filipa; Dahl, J.; Nielsen, Liza Rosenbaum

    2010-01-01

    The Danish Salmonella Surveillance-and-Control Programme in finisher pigs includes both herd and carcass surveillance. Herd surveillance consists of serological testing of meat-juice samples and classification of herds into three Salmonella seroprevalence levels. At the abattoirs, carcass swabs f...

  16. Analysis on situation of hearing loss in noise-exposed drilling workers in some oilfield%某油田钻井作业工人听力损失状况分析

    Institute of Scientific and Technical Information of China (English)

    荆青山; 臧静; 王春玲

    2012-01-01

    Objective To explore the effects of productive noise on hearing of drilling workers in some oilfield. Methods The noise levels in workplace of the oil drilling company were detected systematically, meanwhile, the hearing of 483 noise-exposed workers and 4 91 workers without noise exposure were examined by pure tone audiometer. Results The results showed that the incidence of hearing loss in these noise-exposed workers was 28. 40% , the rates of hearing loss in both high frequency and language frequency were significantly higher than those of control group(P<0. 01) ;The y tend test suggested that the incidence of high frequency hearing loss showed some rising trend along with the noise-exposed length and the cumulative noise exposure(CNK) , the difference was statically significant(P<0. 01). Conclusion The hearing of drilling workers already injured by the productive noise, it is necessary to take active preventive measures immediately for protecting workers,health.%目的 通过对某油田钻井公司作业环境生产性噪声暴露的测量以及作业工人的听力检查,探讨钻井行业噪声对钻井作业工人听力的影响.方法 对钻井公司作业环境进行噪声监测.用纯音听力计检查噪声组483名钻井作业工人和对照组491名后勤工人的听力并分析检查结果.结果 本次调查检出高频听力损失率为28.40%,噪声组在高频及语频听力损失检出率均高于对照组(P<0.01);经χ2趋势检验,随着工龄的增加,钻井作业工人高频听力损失检出率有增加的趋势(P<0.01);随着累积噪声暴露量(CNE)的增加,高频听力损失检出率也有增加的趋势(P<0.01).结论 该油田钻井作业工人听力有明显损失,应积极采取一、二级预防措施来保障工人的健康状况.

  17. Pneumoconiosis in rubber workers

    International Nuclear Information System (INIS)

    Radiographic survey carried out on rubber workers revealed that 32 % (24/76) of the workers showed pneumoconiosis. The cases of pneumoconiosis were found in workers who had been exposed to dust for more than 10 years. Among the 24 cases of pneumoconiosis, 15 workers had been exposed to talc dust for more than 12 years. Chest radiographs of the rubber workers who had been exposed to dust for more than 10 years demonstrated radiographic findings and incidences as follows; nodular pattern (16 %), fine reticular and granular pattern (52 %), reticular pattern (36 %), irregularity of lung markings (61 %), ground-glass appearance (8 %), and pleural thickening (15 %). Irregular opacities such as fine reticular and granular pattern, reticular pattern and irregularity of lung markings seen to be major radiographic findings of pneumoconiosis of the rubber workers. While, nodular pattern seen in upper and middle lung zones and pleural thickening seen in apices and upper lung zones seen to be minor changes. (author)

  18. Nuclear worker and ionizing radiation

    International Nuclear Information System (INIS)

    Research on medical X-ray exposure sheds light on the health effects expected for workers exposed to ionizing radiation. Factual information confirming this relationship and also demonstrating the need for reviewing permissible exposure levels for workers is given. Suggestions for more sophisticated health monitoring of workers exposed to hazardous technologies are made, and the question of occupational hazards which threaten the worker's family is raised

  19. Cytogenetic damage in Turkish coke oven workers exposed to polycyclic aromatic hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms.

    Science.gov (United States)

    Ada, Ahmet Oguz; Demiroglu, Canan; Yilmazer, Meltem; Suzen, Halit Sinan; Demirbag, Ali Eba; Efe, Sibel; Alemdar, Yilmaz; Iscan, Mumtaz; Burgaz, Sema

    2013-09-01

    The aim of this study was to determine the frequencies of chromosomal aberrations (CA) and cytochalasin-blocked micronuclei (CBMN) in peripheral blood lymphocytes from Turkish coke oven workers and the influence of CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms on these biomarkers. Cytogenetic analysis showed that occupational exposure significantly increased the CA and CBMN frequencies. Gene polymorphisms, on the other hand, did not affect CA or CBMN in either exposed or control subjects. However, due to the limited sample size, our findings need to be verified in future studies with a larger sample. PMID:24084344

  20. The protection effect of garlic on biological membrane and on cellular immunity in workers exposed to coke oven volatiles%大蒜对锅炉工生物膜和细胞免疫的保护作用

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@ The workers exposed to coke oven volatile are the risk population of occupational lung cancer than genera population. Polycyclic aromatic hydrocarbons (PAHs),a component of coke oven volatile (COE), are the species considered to be the responsible for this high risk of occupational lung cancer. One of most important mechanism of occupational lung cancer induced by PAHs is believed to be due to the accumulation of free radicals associated with COV and subsequent biological member injury caused by free radical reaction as well as decrease in cell immunity. Garlic is the consumed vegetable with a variety of medical functions.

  1. Blood Lead, Urine Lead and Blood Test Results of Lead Exposed Workers%铅作业工人血铅、尿铅和血常规检测结果分析

    Institute of Scientific and Technical Information of China (English)

    樊宁; 刘凤兰; 蒋培荣

    2011-01-01

    [Objective]To compare the difference of levels of blood lead, urine lead and hemoglobin between workers with lead exposure and workers without lead exposure, and understand the health status of workers with long-term lead exposure. [ Methods ] Level determination of blood lead, urine lead and hemoglobin were performed on 400 workers with lead exposure and 120 workers without lead exposure from a storage battery factory in Tianjin in 2009. The results were analyzed statistically. [Results] Hemoglobin levels in lead-exposed workers were lower than those in non lead-exposed workers, while the blood lead, urine lead levels were significantly higher than those in non lead-exposed workers( P <0.01). The blood lead level was negatively associated with the hemoglobin level(r = -0.442). The relevance between urine lead level and blood lead, hemoglobin level is not ideal respectively (r values were -0.026 and -0.018). [ Conclusion]Long-term low lead exposure can induce blood lead and urine lead levels elevated. While the decrease of lead with severe fluctuation of urine lead are induced by many factors, so these indexes can not accurately reflect the lead volume in the body and have less correlation with other indexes.%目的 比较铅作业工人和非铅作业工人血铅、尿铅和血红蛋白浓度的差异.了解长期低铅作业工人的健康状况.方法 对2009年天津市某蓄电池厂400例铅作业工人和120例非铅作业工人分别进行血铅、尿铅和血红蛋白浓度的测定,并对结果进行统计学处理.结果 铅作业组血红蛋白浓度低于非铅作业组.而血铅、尿铅浓度均显著高于非铅作业组(P<0.01).并且血铅和血红蛋白浓度间呈负相关性(r=-0.442),尿铅与血铅和血红蛋白间的相关性均不理想(r值分别为-0.026和-0.018).结论 长期低铅作业可导致人体血铅尿铅升高,血红蛋白降低,但尿铅浓度波动大,且影响因素多,不能精确反映体内铅积蓄量,结果与其他指标的相关性较差.

  2. Dose estimate for effective internal contamination in the occupationally exposed workers(OEW) that handling open sources for thyroid therapy using 131 I (3779)

    International Nuclear Information System (INIS)

    Handling of a variety of unsealed sources in Nuclear Medicine has led a significant risk of internal exposure of workers. 131I stands out among the radionuclides of frequent use due its wide application in diagnosis and treatment of thyroid diseases. The increasing radionuclide use for medical purposes and treatment of diseases creates a need for capable methodologies of controlling the internal contamination of work. Currently, in Venezuela, there are about 17 Nuclear Medicine Services between public and private, of which 5 are operating; however, individual monitoring is still limited in the control of internal exposure. This work presents the development of bioassay techniques 'in vivo', in order to quantify the incorporation of 131I used in Nuclear Medicine. It also presents the research results of internal exposure of a group of workers involved in handling of therapeutic dose of 131I . The 'in vivo' detection system was calibrated with the thyroid simulator developed at the Institute of Radiologic Protection and Dosimetry (IRD, Rio de Janeiro - Brazil) and which also has the UTN-IVIC (Caracas - Venezuela). The results showed that the bioassay method developed in this work has sufficient sensitivity for its use in routine intake survey of workers in Nuclear Medicine. Between the two workers controlled in this study, both had measurable results in terms of incorporation. Therefore, it is important to keep control of it and also gives us the possibility to evaluate the incorporations in suspected accident. The highest estimate of the effective dose was 1,28x10-5 Sv by inhalation and 1,27x10-5 Sv by ingestion

  3. Point Prevalence of Toxocara vitulorum in Large Ruminants Slaughtered at Multan Abattoir

    Directory of Open Access Journals (Sweden)

    M. Asif Raza*, Saeed Murtaza1, H. Allah Bachaya2, Abdul Qayyum3, M. Arfan Zaman4

    2010-10-01

    Full Text Available The present study was conducted to determine the point prevalence of Toxocara (T. vitulorum in buffalo and cattle slaughtered at Multan abattoir. Gastro-intestinal tracts of 94 buffaloes and 48 cattle were examined for T. vitulorum. Prevalence of T. vitulorum was 63.83 and 37.50% in buffaloes and cattle, respectively. Sex wise prevalence of T. vitulorum was recorded as 39.46% (30/76 in male and 72.72% (48/66 in female.

  4. Dose evaluation in occupationally exposed workers through dosimeters ring and wrist type with an anthropomorphic phantom; Evaluacion de la dosis en trabajadores ocupacionalmente expuestos a traves de dosimetros tipo anillo y de muneca con un fantoma antropomorfico

    Energy Technology Data Exchange (ETDEWEB)

    Palma, R.; Gastelo, E. [Univesidad Nacional Pedro Ruiz Gallo, Huamachuco, Lambayeque (Peru); Paucar, R.; Tolentino, D.; Herrera, J. [Complejo Hospitalario San Pablo, Lima (Peru); Armas, D., E-mail: fispalma@hotmail.com [Consorcio Proxtronics del Pacifico S. A. C., Cal. Manuela Estacio Mza. D1-2 Lote 13, San Miguel, Lima (Peru)

    2014-08-15

    In the Nuclear Medicine service of the Clinica San Pablo (Peru), the occupationally exposed workers carried out the preparation and administration of radiopharmaceuticals to patients, so it is vital to measure the equivalent dose to the hands during the procedures in order to optimize the exposure to the ionizing radiation and execute the Radiological Safety Regulation (D.S. No. 009-97-Em) and the standard IR 002.2012 of radiation protection and safety in nuclear medicine. In this paper was designed and built a hand anthropomorphic phantom made of paraffin following the description given for the standard man, later were placed dosimeters ring and wrist type UD-807 model, Panasonic brand. Then we proceeded to irradiate using vial containers of Tc-99 and I-131. The obtained results showed the difference between the equivalent dose obtained among the ring and wrist dosimeter also getting a dose of 153 mSv /year when working with {sup 99m}Tc and of 61 mSv /year when working with iodine-131. Was also demonstrated that the ring dosimeter shows the average dose received in the hand with less dispersion. It was found that under the national regulation on Requirements of Radiation Protection and Nuclear Safety in Medicine article 63, indicates that higher doses of 150 mSv /year the occupationally exposed workers should have hand dosimetry. Finally the individual dose limit of 500 mSv /year in extremities can be overcome if adequate radiation protection standards do not apply. (author)

  5. Results of occupational health examination of workers exposed to noise in a tungsten-molybdenum plant%某钨钼厂噪声作业工人职业健康检查结果

    Institute of Scientific and Technical Information of China (English)

    陈晓培; 牛心华

    2013-01-01

    目的 探讨生产性噪声对钨钼厂作业工人心血管系统的影响.方法 以某钨钼厂接触噪声作业的393人为接触组,另选非噪声作业工人386人为对照组,对两组人群进行职业健康检查、血压测量及心电图检查,两组检查结果用卡方检验进行统计学分析.结果 噪声接触组的血压及心电图异常发生率高于对照组,两者的差异有统计学意义(P<0.01);不同年龄组、不同工龄组的噪声接触组的血压异常率明显高于对照组(P<0.05),并且随着年龄及工龄的增加,血压异常率有增加的趋势;年龄在20 ~ 30岁及工龄在0~10a的噪声接触组的心电图异常率明显高于对照组(P<0.05),其他年龄组及工龄组间的噪声接触组与对照组心电图异常率无明显差异.结论 噪声对钨钼厂作业工人心血管系统可产生不同程度的影响,应加强防护措施.%[Objective]To investigate the effect of productive noise on cardiovascular system of workers in a tungsten-molybdenum plant. [Methods]Totally 393 workers with noise exposed were selected as exposure group, anther 386 workers without noise exposure as control group, the two groups received routine medical examinations, blood pressure measurement and electrocardiogram. The results were statistically analyzed by using Chi square test. [Results]The incidence of abnormal blood pressure and electrocardiogram of the noise exposure group were higher than that of the control group, with significant difference( P <0.01). The abnormal blood pressure rate of noise-exposed group with different age and different service length was significantly higher than the control group(P<0.05) , and with the extending age and service length, abnormal blood pressure rate was increased. The abnormal ECG rates of noise-exposed workers with age of 20-30 years and service length of 0-10 years were significantly higher than the control groupf (P <0. 05) , that between noise-exposed workers of

  6. Analysis on situation of hearing loss in noise-exposed workers in a boiler factory%某锅炉厂噪声作业工人听力损失状况分析

    Institute of Scientific and Technical Information of China (English)

    倪蕾; 姚勇; 李济超; 吴静; 严雁翎; 张婷; 吴秋芳

    2011-01-01

    目的 拟通过对某锅炉厂作业环境生产性噪声暴露的测量以及作业人员的听力检查,探讨锅炉生产行业噪声对作业人员听力的影响.方法 对某锅炉厂噪声环境进行监测.用纯音听力计检查观察组105名工人和对照组109名工人的听力并分析检查结果.结果 本次调查检出高频听力损失者61人,检出率为58.10%;观察组在语频及高频听力损失检出率均大于对照组(P值均小于0.05);观察组工人的双耳听力损伤基本一致,听阈的平均值在3000~4000 Hz频率明显高于对照组(P趋势检验,随着噪声作业工龄的增加,接触噪声作业工人高频听力损失检出率有增加的趋势(P=0.0001);随着日噪声接触量(8 h等效A声级)增加,高频听力损失检出率有升高趋势(P=0.0017);随着累积噪声暴露量(CNE)增加,高频听力损失检出率也有增加的趋势(P=0.0004).结论 该厂噪声对作业人员听力已经产生了明显影响,应采取积极的综合预防措施来控制噪声对作业人员健康的影响.%Objective To explore the effects of productive noise on hearing of workers in a boiler factory. Methods The noise levels in workplaces of the factory were detected systematically, meanwhile, the hearing of 105 noise-exposed workers and 109 workers without noise exposure were examined by pure tone audiometer. Results The results showed that 61 workers were determined as high-frequency hearing loss, the incidence of hearing loss in these noise-exposed workers was 58. 10%, the rates of hearing loss in both language frequency and high frequency were significantly higher than those of control group (P < 0. 05 );the average hearing threshold of 3000-4000 Hz in noise-exposure group was all significantly higher than that of control group (P <0. 05), the hearing loss of bilateral ears basically was coincident. The x2 trend test suggested that the incidence of high-frequency hearing loss showed some rising trend along with the

  7. Human and canine echinococcosis infection in informal, unlicensed abattoirs in Lima, Peru.

    Directory of Open Access Journals (Sweden)

    Maria M Reyes

    Full Text Available Echinococcus granulosus infections are a major public health problem in livestock-raising regions around the world. The life cycle of this tapeworm is sustained between dogs (definitive host, canine echinococcosis, and herbivores (intermediary host, cystic hydatid disease. Humans may also develop cystic hydatid disease. Echinococcosis is endemic in rural areas of Peru; nevertheless, its presence or the extension of the problem in urban areas is basically unknown. Migration into Lima, an 8-million habitant's metropolis, creates peripheral areas where animals brought from endemic areas are slaughtered without veterinary supervision. We identified eight informal, unlicensed abattoirs in a peripheral district of Lima and performed a cross-sectional study in to assess the prevalence of canine echinococcosis, evaluated by coproELISA followed by PCR evaluation and arecoline purge. Eight of 22 dogs (36% were positive to coproELISA, and four (18% were confirmed to be infected with E. granulosus tapeworms either by PCR or direct observation (purge. Later evaluation of the human population living in these abattoirs using abdominal ultrasound, chest X-rays and serology, found 3 out of 32 (9.3% subjects with echinococcal cysts in the liver (two viable, one calcified, one of whom had also lung involvement and a strongly positive antibody response. Autochthonous transmission of E. granulosus is present in Lima. Informal, unlicensed abattoirs may be sources of infection to neighbouring people in this urban environment.

  8. Cohort studies on cancer mortality of digestive system among workers exposed to asbestos:a meta-analysis%石棉接触人员消化系统癌症死亡队列研究的Meta分析

    Institute of Scientific and Technical Information of China (English)

    孙统达; 陈健尔; 张秀娟; 李秀央

    2008-01-01

    Objective To determine if there are excessive risks of malignant tumors or not among workers exposed to asbestos by applying a meta-analysis technique. Methods All clata meeting the criteria of cohort studies on cancer mortality of digestive system among workers exposed to asbestos would be incorporated into the meta-analysis. The pooled standardized mortality ratios (SMR) and their corresponding 95% confidence intervals (CIs) for main cancer sites of digestive system were calculated by using two approaches of unweighted ratio and random effects model. The heterogeneity and its sources of the results were examined with a Q-statistic and Z-score test. Results 69 asbestos-exposed cohorts were summarized. The significantly elevated meta-SMR for all deaths (1.16),all cancers (1.42),cancer of digestive system (1.15) and cancer of stomach (1.20) among workers exposed to chrysotile alone or mixed asbestos were observed (P<0.01). The stomach cancer SMR was significantly increased in the asbestos cement workers,the screening mine workes and the insulators, (1.27,1.21 and 2.13 respectively) (P<0.05). meta-SMR for cancers at other sites of digestive system induding esophagus, colon, rectum and liver were not significant. Conclusion There are likely excessive risks of cancer of stomach among workers exposed to asbestos. However, there is likely no convincing indication of an etiological association between asbestos exposure and cancers at other sites of digestive system.%目的 以Meta分析探讨石棉接触者消化系统癌症是否高发.方法 凡满足明确是石棉接触人员且为消化系统癌症死亡率队列研究的资料均被纳入研究对象,以直接法与随机效应模型法计算消化系统主要部位癌症标准化死亡比(SMR)及其95%可信区间(CI),计算Q统计量与Z值检验研究结果异质性及其来源.结果 共有69个队列符合入选标准,单纯接触温石棉、温石棉与闪石类石棉混合作业的人员,全死因、全癌

  9. 噪声作业工人血清同型半胱氨酸及血脂水平研究%Investigation on the serum homocysteine and blood-lipid in workers exposed to noise

    Institute of Scientific and Technical Information of China (English)

    李成林; 李侠; 高珊珊

    2016-01-01

    目的:探讨职业性噪声接触对作业工人血清同型半胱氨酸( Hcy)及血脂水平的影响。方法采用整群抽样方法,选取山东省3家噪声作业工厂从事噪声作业的247名工人为接触组,以同厂非噪声作业的198名工人为对照组。采用循环酶法分别检测作业工人血清Hcy、甘油三酯( TG)、总胆固醇( TC)、高密度脂蛋白( HDL)和低密度脂蛋白( LDL)水平,采用多因素Logistic回归分析作业工人高Hcy血症的影响因素。结果3家工厂工作场所噪声8 h等效声级超标率为44.4%~50.0%。接触组男、女性工人血清Hcy水平分别高于对照组同性别工人( P<0.01),接触组女性工人HDL水平低于对照组女性工人(P<0.01);2组工人血清TG、TC和LDL分别比较,差异均无统计学意义(P>0.05)。接触组工人高Hcy血症检出率高于对照组工人(91.50% vs 56.57%,P<0.01)。从事噪声作业和性别均是导致作业工人发生高Hcy血症的影响因素( P<0.01)。噪声作业工人发生高Hcy血症的比值比(OR)是非噪声作业工人的2.78倍,男性工人发生高Hcy血症的OR是女性工人的6.21倍。结论职业性噪声接触可导致作业工人Hcy水平升高。%Objective To explore the effects of occupational noise exposure on the levels of serum homocysteine ( Hcy ) and blood lipid in workers.Methods By cluster sampling method, 247 workers from 3 noisy operational factories in Shandong Province were selected as exposure group, and 198 non-noise exposed workers from the same factories were chosen as the control group.The levels of Hcy, triglyceride ( TG ) , total cholesterol ( TC ) , high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were examined using enzymatic cycling assay.The influence factors of high Hcy levels in workers were analyzed by multiple Logistic regression analysis.Results The over standard rate of 8

  10. Hearing Survey of Noise Exposed Workers in A Steel Cord Products Factory in Jiangyin City%江阴市某钢帘线制品厂噪声作业人员听力调查

    Institute of Scientific and Technical Information of China (English)

    张捷; 冯鸿义; 徐秀芬; 陈婷; 金宇星

    2011-01-01

    目的 了解某钢帘线制品厂噪声作业人员听力损失状况,为采取有效的职业病危害防护措施提供依据.方法 测试某钢帘线制品厂噪声作业人员双耳气导听阈,结果按GB/T 7582标准对听阈作年龄和性别修正,按年龄、接害工龄分组分析听力损失状况.结果该厂79个噪声监测点中,除7个点合格外,其余均不同程度超过GBZ 2.2 - 2007的要求;调查对象1 040人中,23人双耳高频平均听阈≥40 dB(HL)为观察对象,占总调查人数的2.21%;疑似职业性听力损伤18人.在同一年龄组,随接害工龄增长职业性听力损伤检出率有增高的趋势.结论 钢帘线制品行业中,生产性噪声对作业人员听力损害较大,应控制生产环境噪声强度,做好作业人员个体防护及职业健康检查.%[Objective]To understand the hearing loss of noise exposed workers in a steel cord products factory, and provide evidence for adopting effective protection measures against occupational hazards. [ Methods ] Binaural air conduction audiometry was performed on noise exposed workers,hearing results were modified according to age and sex with CB/T 7582 standard,analysis of hearing loss was based on age groups and service length groups. [ Results]7 out of 79 noise monitoring sites points were qualified,the other exceeded national health standards CBZ 2.2 -2007. Of 1 040 noise exposed workers,23 workers' binaural high frequency average hearing threshold ≥40dB( HL),occupied 2.21% of total workers. 18 were detected suspected occupational hearing loss. Occupational hearing loss showed a growing trend in detection rates increasing with the service length in the same age group. [ Conclusion] It is important to control noise intensity in workplace and strengthen the personal protection of workers and occupational health examination, because great degree of hearing loss for noise is found in the steel cord products industry.

  11. Application of Cloud Point Extraction for Cadmium in Biological Samples of Occupationally Exposed Workers: Relation Between Cadmium Exposure and Renal Lesion.

    Science.gov (United States)

    Mortada, Wael I; Hassanien, Mohamed M; Donia, Ahmed F; Shokeir, Ahmed A

    2015-12-01

    Cadmium (Cd) level in blood and urine of soldering iron workers (n=49) and 41 matched healthy controls has been assessed. Cloud point extraction was employed for preconcentration of Cd. The Cd ions formed hydrophobic complex with 9,10-phenanthraquinone monoethyl thiosemicarbazone that was extracted by surfactant-rich phases in the nonionic surfactant Triton X-114. The surfactant-rich phase was diluted with 1 M HNO3 in methanol prior to its analysis by graphite furnace atomic absorption spectrometry. The parameters affecting the extraction efficiency of the proposed method, such as solution pH, amount of complexing agent, surfactant concentration, temperature, and incubation time, were optimized. Under the optimum experimental conditions, the detection limit and the enrichment factor were 0.04 μg L(-1) and 61, respectively. Relative standard deviation of 10 μg L(-1) Cd was less than 3.0%. The accuracy of the method was examined by analysis of certified reference materials. It was observed that soldering iron workers are liable to Cd overload as indicated by higher levels of Cd in blood and urine when compared with the controls. This exposure may lead to kidney damage indicated by elevation of urinary excretion of both N-acetyl-β-D-glucosaminidase and β2-microglobulin.

  12. Publication of the first results of the INWORKS epidemiological study on the leukemia and lymphoma risk among the nuclear industry workers chronically exposed to low ionizing radiation doses

    International Nuclear Information System (INIS)

    There is much uncertainty about the risks of leukaemia and lymphoma after repeated or protracted low-dose radiation exposure typical of occupational, environmental, and diagnostic medical settings. Associations between protracted low-dose radiation exposures and leukaemia, lymphoma, and multiple myeloma mortality among radiation-monitored adults employed in France, the UK, and the USA were quantified. A cohort of 308297 radiation-monitored workers employed for at least 1 year by the Atomic Energy Commission, AREVA Nuclear Cycle, or the National Electricity Company in France, the Departments of Energy and Defence in the USA, and nuclear industry employers included in the National Registry for Radiation Workers in the UK was assembled. The cohort was followed up for a total of 8.22 million person-years. Deaths caused by leukaemia, lymphoma, and multiple myeloma were ascertained. Poisson regression to quantify associations between estimated red bone marrow absorbed dose and leukaemia and lymphoma mortality was used. Doses were accrued at very low rates (mean 1.1 mGy per year, SD 2.6). The excess relative risk of leukaemia mortality (excluding chronic lymphocytic leukaemia) was 2.96 per Gy (90% CI 1.17-5.21; lagged 2 years), most notably because of an association between radiation dose and mortality from chronic myeloid leukaemia (excess relative risk per Gy 10.45, 90% CI 4.48-19.65). This study provides strong evidence of positive associations between protracted low-dose radiation exposure and leukaemia

  13. Evaluation of liver enzyme levels in workers exposed to vinyl chloride vapors in a petrochemical complex: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Dolati Mandana

    2007-08-01

    Full Text Available Abstract Background Polyvinyl chloride is used in production and manufacturing of many essential tools (e.g. plastic pipes, photography films, etc.. Its production is impossible without the use of vinyl chloride monomer (VCM, which can cause liver damage in long-term. In this study we intend to assess the effects of mild to moderate long term exposure to VCM on liver and to assess the importance of liver enzyme measurements as a screening tool. Methods In this study, liver enzyme levels of 52 workers were compared to 48 control workers using the T-test. The cases all worked in a PVC production unit in a petrochemical complex and the controls were randomly selected from office personnel of the same complex. A questionnaire was also filled in about information such as age, weight, work history, etc. in both groups. Results Mean comparisons for ALP and GGT using T-test showed statistically significant differences between the two groups. For AST, ALT and bilirubin (total, direct the mean was higher in the case group but this difference was not statistically significant. Discussion This study showed that mild exposure to VCM can cause mild liver cholestasis. So, using cholestasis assessment tests such as ALP and GGT should be considered in periodic assessment of liver function in PVC producing units.

  14. Investigation on health status of styrene-exposed workers in a track enterprise of Qingdao City%青岛某轨道公司苯乙烯作业工人的健康状况调查

    Institute of Scientific and Technical Information of China (English)

    陈学磊; 邵华

    2012-01-01

    [ Objective] To understand the health status of styrene-exposed workers by working conditions and health survey. [Methods] A study on 126 paste production workers exposed to styrene and 149 non-paste production matched referents was performed to examine the influence factors of styrene-exposed workers, by spot and individual testing, health investigation and medical examination. [Results]The styrene levels of paste area inside orbital compartment was of (111. 62 ±53.95) mg/m3, that of non-paste area was (1.89 ±0.67) mg/m3, the difference was significant (χ2 =12. 862,P<0.01). The incidence rates of cold, dizziness, cough, abdominal pain, diarrhea, and skin lesions of exposed group were higher than those of the control group(P <0.01 or P<0.05). [ Conclusion ] The health of styrene-exposed workers is not optimistic in orbital compartment. This survey subjects are young with short exposure length, so the styrene effects on the body has yet to continue observe.%目的 通过对苯乙烯作业工人工作环境以及健康调查,了解苯乙烯对工人的健康影响.方法 选择126名苯乙烯糊制作业者为观察组以及149名非糊制作业者为对照组,通过现场定点及个体检测,工人健康调查以及体检,分析苯乙烯对工人的健康影响.结果 轨道车厢苯乙烯作业工人工作环境中糊制区浓度为(111.62±53.95) mg/m3,非糊制区浓度为(1.89±0.67)mg/m3,两区浓度差异有统计学意义(X2=12.862,P<0.01).苯乙烯工人感冒、头晕、咳嗽、腹痛腹泻、皮肤损害发生率高于对照组(P<0.01或P<0.05).结论 苯乙烯轨道车厢作业工人的健康状况不容乐观,此调查对象为年轻者以及接触年限较短,苯乙烯对身体的影响还有待于继续观察.

  15. 蓄酸电池厂铅作业工人血铅异常回顾性队列研究%A retrospective cohort study on abnormal blood lead levels in lead-exposed workers in a storage battery factory

    Institute of Scientific and Technical Information of China (English)

    周齐红; 付风云; 俞慧娟; 任阳春; 叶海朋

    2016-01-01

    Objective To analyze the influencing factors of high blood lead levels in lead-exposed workers of a storage battery factory .Methods By the typical sampling method , lead-exposed workers were chosen as study subjects for a three-year retrospective cohort study starting from September of 2011 and ending in September of 2014.The starting blood lead level was <400.0μg/L and ending blood lead level was ≥400.0μg/L ( abnormal level ) .The influencing factors of abnormal blood lead level were analyzed by the COX regression analysis method .Results There were 244 lead-exposed workers included in this study .The median (M) working years of baseline lead exposure was 6.3 (0.7-35.9) years, the M of baseline blood lead level was 321.5 (215.7-398.7) μg/L by September of 2011.During the 3 years, there were 78 workers found to have abnormal blood lead levels , with an abnormality rate of 32.0%.The multivariable COX regression analysis indicated that the workers with following situations had relative higher incidences of abnormal blood lead level :working without masks , baseline blood lead level over 300.0 μg/L, the air concentration of lead in workplace beyond the standard and the workers exposed to lead for over 5.0 years, their relative risk ratios were 6.89, 4.00, 9.02 and 2.93 times of those workers with the opposite situations , respectively ( P<0.01 ) .Conclusion Measures should be taken to prevent and control the occupational chronic lead poisoning especially in those lead -exposed workers who don ’t wear masks during work, whose baseline blood lead level was over 300.0 μg/L, whose air concentrations of lead in workplace were beyond the standard and whose lead exposure year was over 5.0 years.%目的:分析蓄电池厂铅作业工人血铅异常的影响因素。方法采用典型抽样方法,以某蓄电池厂的铅作业工人为研究对象,进行为期3年的回顾性队列研究。起点时间为2011年9月,起点事件为血铅水平<400.0μg

  16. Reduced nucleotide excision repair and GSTM1-null genotypes influence anti-B(a)PDE-DNA adduct levels in mononuclear white blood cells of highly PAH-exposed coke oven workers

    Energy Technology Data Exchange (ETDEWEB)

    Sofia Pavanello; Alessandra Pulliero; Ewa Siwinska; Danuta Mielzynska; Erminio Clonfero [University of Padova, Padova (Italy). Occupational Health Section, Department of Environmental Medicine and Public Health

    2005-07-01

    It is important to identify the potential genetic-susceptible factors that are able to modulate individual responses to exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs). In the present study we evaluated the influence of four polymorphisms of nucleotide excision repair (NER) genes and that of glutathione S-transferase {mu}1 (GSTM1-active or -null) on benzo(a)pyrene diol epoxide (B(a)PDE)-DNA adduct levels from the lympho-monocyte fraction (LMF) of highly PAH benzo(a)pyrene -exposed Polish coke oven workers with individual urinary post-shift excretion of 1-pyrenol exceeding the proposed biological exposure index. The bulky {+-}-r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene (anti-B(a)PDE)-DNA adduct levels were detected by high-performance liquid chromatography fluorescence analysis and genotypes by polymerase chain reaction. We found that workers with the low DNA repair capacity of XPC-PAT+/+ and XPA-A23A genotypes had increased anti-B(a)PDE-DNA adduct levels, DNA adducts were also raised in workers without GSTM1 activity. Workers with unfavourable XPC-PAT+/+ and XPA-A23A NER genotypes, alone or combined with GSTM1-null genotype were in the tertile with the highest adduct level. The increase in anti-B(a)PDE-DNA adduct levels was related in a multiple linear regression analysis to PAH exposure lack of GSTM1 activity and to low DNA repair capacity of the XPC-PAT+/+ genotype. The influence of the XPA-A23A genotype was not evident in this statistical analysis, and no associations with XPD polymorphisms, dietary habits or tobacco smoking were found. The modulation of anti-B(a)PDE-DNA adducts in the LMF by GSTM1-null and some low-activity NER genotypes may be considered as a potential genetic susceptibility factor capable of modulating individual responses to PAH genotoxic exposure and the consequent risk of cancer in coke oven workers.

  17. Features of hearing loss in noise-exposed workers in electronic technology enterprises%电子技术企业噪声作业工人听力损失特点分析

    Institute of Scientific and Technical Information of China (English)

    张庆年; 陈真富; 钟茂耀; 吴木生; 张盈盈

    2012-01-01

    目的 了解电子技术企业噪声作业工人听力损失的特点,为采取控制和消除职业性噪声聋的发生提供依据.方法 对两家电子技术企业进行职业卫生调查,以噪声作业车间495名工人为噪声组,以150例无职业危害作业工人为对照组,用常规方法测量每个工人的左右耳气导听阈,按照GBZ47-2007计算平均听阈和判定听力状态,比较两组工人听力状况,并对噪声组听力损失进行统计学分析.结果 噪声组、对照组听力损失检出率分别为14.9%和1.3%,两组比较,差异有极显著性(P< 0.01).噪声组中,接触非稳态噪声、稳态噪声工人的听力损失检出率分别为15.3%、12.5%,冲压、打磨和粉碎工种工人的听力损失检出率分别为15.3%、13.3%和11.8%,工龄为<5、5~、10~年组工人的听力损失检出率分别为8.2%、28.4%和38.3%,年龄为<25、25~、39~岁组工人的听力损失检出率分别为0.0%、17.9%和29.6%;不同工种、不同类型噪声接触工人的听力损失检出率比较,差异均无显著性(P> 0.05);x2趋势检验示,随着噪声作业工龄的增加、年龄的增加,听力损失检出率增加(P<0.01);逐步多因素Logistic回归分析显示,工龄、年龄是听力损失的独立危险因素.结论 电子技术行业高强度噪声引起作业人员听力损失,加强职业病防治管理措施,对降低职业性噪声聋的发生有重要意义.%Objective To provide support for the control and elimination of occupational noise-induced hearing loss by exploring the features of hearing loss in noise-exposed workers in electronic technology enterprises.Methods A survey on occupational health was conducted in two enterprises.495 workers exposed to environmental noise in the enterprises were studied as noise-exposed group and 160 workers with no noise exposure enrolled as control group.The air conduction thresholds were detected in both ears by routine

  18. Factors associated with whole carcass condemnation rates in provincially-inspected abattoirs in Ontario 2001-2007: implications for food animal syndromic surveillance

    Directory of Open Access Journals (Sweden)

    Alton Gillian D

    2010-08-01

    Full Text Available Abstract Background Ontario provincial abattoirs have the potential to be important sources of syndromic surveillance data for emerging diseases of concern to animal health, public health and food safety. The objectives of this study were to: (1 describe provincially inspected abattoirs processing cattle in Ontario in terms of the number of abattoirs, the number of weeks abattoirs process cattle, geographical distribution, types of whole carcass condemnations reported, and the distance animals are shipped for slaughter; and (2 identify various seasonal, secular, disease and non-disease factors that might bias the results of quantitative methods, such as cluster detection methods, used for food animal syndromic surveillance. Results Data were collected from the Ontario Ministry of Agriculture, Food and Rural Affairs and the Ontario Cattlemen's Association regarding whole carcass condemnation rates for cattle animal classes, abattoir compliance ratings, and the monthly sales-yard price for various cattle classes from 2001-2007. To analyze the association between condemnation rates and potential explanatory variables including abattoir characteristics, season, year and commodity price, as well as animal class, negative binomial regression models were fit using generalized estimating equations (GEE to account for autocorrelation among observations from the same abattoir. Results of the fitted model found animal class, year, season, price, and audit rating are associated with condemnation rates in Ontario abattoirs. In addition, a subset of data was used to estimate the average distance cattle are shipped to Ontario provincial abattoirs. The median distance from the farm to the abattoir was approximately 82 km, and 75% of cattle were shipped less than 100 km. Conclusions The results suggest that secular and seasonal trends, as well as some non-disease factors will need to be corrected for when applying quantitative methods for syndromic surveillance

  19. Blood parameters and corneal-reflex of finishing pigs with and without lung affections observed post mortem in two abattoirs stunning with CO₂.

    Science.gov (United States)

    Fries, R; Rindermann, G; Siegling-Vlitakis, C; Bandick, N; Bräutigam, L; Buschulte, A; Irsigler, H; Wolf, K; Hartmann, H

    2013-02-01

    In two pig abattoirs of different slaughter capacities, the stunning efficacy of CO2 on finishing pigs with and without pneumonic lesions (observed post mortem) was reflected against the corneal-reflex and blood parameters (blood pH, pCO2 and pO2) from individual finishers. Stunning duration was 120 s (abattoir A) and 90 s (abattoir B), respectively. Pneumonia in finisher pigs is frequently observed during post mortem inspection, which may raise concerns about a delay of unconsciousness because of hampered gas exchange in the lungs. The aim of this study was to examine possible pneumonia consequences for stunning efficacy under commercial conditions. For that, corneal reflex, O2 and CO2 partial pressure in the blood as well as blood pH were measured in 2650 finishers from abattoir A and 2100 from abattoir B. The partial pressure of O2 after stunning accounted to about 3 kPa, the partial pressure of CO2 was found at levels of about 24 kPa in abattoir A (after 120 s CO2 exposure) and 17.5 kPa in abattoir B (after 90 s CO2 exposure). In abattoir A, the blood pH was at 6.9, and at 7.0 in abattoir B. The corneal reflex was observed in 6.2% of pigs in abattoir A and 17.1% of pigs in abattoir B. A correlation between pneumonic lesions and blood status was not observed. However, for some individual farms, a significant correlation between pneumonia and corneal reflex was observed. PMID:22898535

  20. An epidemiological survey of malignant tumors among fluoride-exposed workers in aluminum industry%铝工业接氟工人恶性肿瘤流行病学调查

    Institute of Scientific and Technical Information of China (English)

    阳益萍; 段鹏; 李保秀; 覃丽琳; 陆继培; 韦嘉兴; 韦小敏

    2013-01-01

    Objective To investigate the incidence of malignant tumors among fluoride-exposed workers in aluminum industry.Methods Sampling points were set in the working positions at different radii around an workshop for treating the waste gas from aluminum electrolysis,and the concentrations of fluoride ions,aluminum,and benzo [a]pyrene (B[a]P) in air were measured by electrode method,atomic absorption spectrophotometry,and high performance liquid chromatography,respectively.The incidence of tumors among the workers in the aluminum plant from 1995 to 2009 was investigated by questionnaires and medical records and then statistically analyzed.Results There was a negative correlation between the concentrations of fluoride and aluminum and the radius around the fluoride source at each sampling point.B[a]P was not detected at each sampling point.The crude incidence rate of tumors among factory workers was 117.95/100 000(standardized rate=58.81/100 000); the standardized incidence rate of tumors was higher in female workers than in male workers (male-to-female ratio=1:2.64).The peak age of onset of tumors was 40~49 years.The most and second most common tumors were liver cancer and lung cancer in male workers and breast cancer and lung cancer in female workers.Compared with the unexposed population in the city where the aluminum plant was located,the female fluoride-exposed workers had an increased tumor incidence,2.14 times that of the city's average level,and the fluoride-exposed workers had a younger age of onset of tumors and approximately the same types of tumors.Conclusion Fluoride exposure may lead to an increasing trend in tumor incidence among female workers in aluminum industry.%目的 了解铝工业接氟工人恶性肿瘤的发病情况.方法 以铝电解废气净化车间为中心,在不同半径距离的工作位点设采样点检测空气中的氟、铝和苯并[a]芘浓度,氟离子选择电极法测定氟,原子吸收分光光度法测定铝,高效液相色

  1. Disparities in Beef Tapeworm Identification Rates in the Abattoirs of Gauteng Province, South Africa: A Descriptive Epidemiologic Study.

    Directory of Open Access Journals (Sweden)

    Daniel Nenene Qekwana

    Full Text Available Bovine Taenia saginata cysticercus infections (also called bovine cysticercosis or beef measles is usually diagnosed in cattle only during post-mortem meat inspection. The aim of this study was to investigate the identification rates of these infections in and to identify predictors/determinants of variations in the identification rates in abattoirs in Gauteng province, South Africa.Retrospective data for over 1.4 million cattle carcasses inspected in 26 abattoirs between January 2010 and December 2013 were used for the study. The identification rates (proportion of bovine Taenia saginata cysticercus positive carcasses were computed and generalized estimating equations used to identify predictors/determinants of identification rates.The overall identification rate was 0.70% (95% CI: 0.45, 0.95. Significantly (p0.05 association was identified between identification rates and either the number of meat inspectors per abattoir or the provider of inspection services.Although no significant association was found between identification rates and provider of inspection services, follow-up studies will need to be done to specifically investigate the potential conflict of interest arising from the fact that abattoir owners hire meat inspection services directly. Capture of abattoir surveillance data needs to include farm address and for each case to be reported separately. Finally, information on the type of identified cysts (alive or calcified need to be collected to help better estimate risk to consumers. This study provides useful baseline data to guide future studies, surveillance and control efforts.

  2. Health status of workers exposed to noise in a papermaking enterprise of Zhenjiang City%镇江市某造纸企业噪声作业工人健康状况

    Institute of Scientific and Technical Information of China (English)

    谢石; 葛琴娟; 李艳平; 钱海洋

    2013-01-01

    目的 调查造纸生产过程噪声对造纸作业人员身体健康的影响.方法 选取镇江市某大型造纸企业,对其作业场所噪声强度进行监测;同时选择该企业接触噪声的1717名作业人员作为观察组,其他单位410名行政管理人员作为对照组,对他们进行听力测定、血压、心电图等职业健康检查.对不同工龄接触噪声作业人员体检结果异常率进行统计分析.结果 接触噪声作业人员高频听损率、语频听损率、高血压患病率和心电图异常率分别为22.6%、12.3%、10.4%、22.1%,均高于对照组的8.5%、4.6%、5.4%、16.3%,差异均有统计学意义(x2值分别为41.1、5.6、9.7、6.7,均P<0.05).结论 该造纸生产企业噪声污染普遍存在.长期接触噪声对作业人员的听觉系统及心血管系统影响较大.因此,应对造纸行业的噪声危害采取切实有效的防范措施,以保护工人的健康.%[Objective] To investigate the influence of paper manufacturing noise to the health of the workers with exposure, t Methods] The noise density of different work place was detected in a large papermaking enterprise. The papermaking workers who exposed to noise in the factory were selected as exposed group and some administration staffs in the other factory were recruited as control group. Their physical examination including audiometry, ECG and blood pressure. The abnormal rate of examination results between workers with different length of noise exposure was analyzed statistically. [ Results] The rate of high-frequency hearing loss rate, speech frequency hearing loss rate, abnormal rate of hypertension and abnormal ECG in exposed group (22.6% , 12. 3% , 10.4% , 22.1% respectively) was higher than those of control group(8.5% , 4.6% , 5.4% , 16.3% , respectively. There were significant differences (all P <0.05). [ Conclusion] Noise pollution is prevalent in the papermaking enterprise. The noise has great influence to the

  3. Health care status of female workers exposed to occupational hazards in Haidian district of Beijing%北京市海淀区接触职业病危害作业女工保健状况分析

    Institute of Scientific and Technical Information of China (English)

    林向华; 蔡源源; 王洪波; 时福礼; 狄江丽; 李丽娟; 陶永娴; 王子云; 林英; 丛泽; 刘永泉; 吴琦; 宛玲; 王秀荣; 杜小宁

    2009-01-01

    目的 了解北京市海淀区女工保健工作的现状,提高女工劳动保护水平.方法 对海淀区辖区内监管的141家有女工从事接触职业病危害作业(化学毒物及噪声、振动、微波、高频、低温等物理因素)的单位进行女工保健状况现场问卷调查,并收集相关资料.问卷由中国疾病预防控制中心妇幼保健中心提供.结果 141家单位包括国有企事业单位53家,集体企业21家,股份制企业46家,非公有制企业21家,共有女工12 251名,其中1249名从事职业危害作业,占女工总数的10.19%(1249/12 251).16.31%(23/141)的单位无劳动保护管理机构,27.66%(39/141)的单位无就业前体检,无经期劳动保护管理制度的单位达48.94%(69/141),21.28%(30/141)的单位女工孕期工资发生变化,32.62%(46/141)的单位女工产期工资发生变化,2.13%(3/141)的单位安排女工从事国家禁忌女工从事的劳动(即连续负重作业),9.93%(14/141)的单位安排女工从事孕期禁忌从事的劳动,31.91%(45/141)的单位不将劳动时间内进行产前检查算作劳动时间,39.01%(55/141)的单位不负担女工生育费用,33.33%(47/141)的单位不将哺乳时间计入劳动时间.有68.09%(96/141)的单位每年定期组织女工进行妇科检查.收集到45家单位的职业健康检查报告,占调查单位数的31.91%(45/141),报告中未发现患有职业病的女工.共监测34家单位的1865个职业病危害因素监测点,其中155个监测点不合格,均为噪声作业点.结论 女工保健工作形势不容乐观,要不断完善法律体系、加强宣传、明确监管部门及职责分工,做好女工保健工作.%Objective To investigate the health care status of female workers exposed to occupational hazards in Haidian district of Beijing and improve the labor protection of female workers. Methods A questionnaire provided by National Center for Women and Children's Health of Chinese CDC was used in the survey conducted to collect

  4. Mortality in chemical workers potentially exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) 1945-94: an update

    OpenAIRE

    Burns, C.; Beard, K.; Cartmill, J

    2001-01-01

    OBJECTIVE—To update and add to a previously identified cohort of employees potentially exposed to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). The putative association between 2,4-D and non-Hodgkin's lymphoma has been debated for more than a decade.
METHODS—Cohort members were male employees of The Dow Chemical Company who manufactured or formulated 2,4-D any time from 1945 to the end of 1994. Their mortality experience was compared with national rates and with more than 40 000 other...

  5. 优化正己烷作业人群职业健康监护技术方案研究%Study on optimization of technical program of occupational health surveillance for workers exposed to n-hexane

    Institute of Scientific and Technical Information of China (English)

    陈嘉斌; 黄汉林; 李宏玲; 江嘉欣

    2014-01-01

    目的:建立正己烷作业人群职业健康监护( OHS )优化方案和应用指南,提高职业健康监护的可操作性。方法从循证医学角度出发,对GBZ 188《职业健康监护技术规范》规定的对正己烷作业人群开展上岗前、在岗期间和离岗时OHS的目标疾病、健康检查内容和周期等内容进行分析,以OHS工作中的常见问题为线索,通过中国期刊全文数据库( CNKI)、万方数据库和PubMed进行文献检索,筛选优化指标,提出正己烷作业人群OHS技术优化方案和应用指南,初步推广应用。结果成功建立正己烷作业人群OHS技术优化方案和应用指南。其中,选择神经传导速度、血清神经元特异性烯醇化酶作为生物效应标志物,选择尿2,5-己二酮作为生物接触标志物;鉴别指标增加尿糖检测;职业禁忌证增加伴有周围神经损害表现的糖尿病、维生素B缺乏症、未成年工和孕期、哺乳期女职工。结论优化方案合理可行,实用性较强,适用于正己烷作业人群的OHS实际工作。%Objective To carry out an optimization of technical program of occupational health surveillance( OHS)for workers exposed to n-hexane,and to improve its accessibility. Methods According to the theory of evidence-based medi-cine,this research analyzed the target diseases,screening items and interval period of the pre-employment/on-job/off-post physical examination required by GBZ 188 Technical Specifications of Occupational Health Surveillance,and reviewed the collected articles on common issues of OHS from literature database,such as the China National Knowledge Internet ( CNKI),WanFang and PubMed,in order to select proper indicators,promote an optimization and guideline of OHS for workers exposed to n-hexane with primary application. Results The optimization of technical program and application guide of OHS for workers exposed to n-hexane was established by altering nerve

  6. The follow-up study of ras P21 oncoprotein in workers exposed to polycyclic aromatic hydrocarbons%多环芳烃接触者P21蛋白跟踪研究

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@ Polycyclic Aromatic Hydrocarbons(PAHs),first determined as a sort of chemical carcinogen, can exist in chemical substance such as coal tar pitch (CTP) and coke oven volatiles (COV). The carcinogenesis of PAHs has been confirmed by epidemiological studies among high risk population and animal experiments. The excessive mortality of lung cancer has been found in workers exposed to CTP and COV. Lung cancer can be induced in rats or mice with CTP by inspiring CTP fog or intratracheal instillations. The latest advance in the study of molecular biology has been applied to the fields of occupational cancer prevention and diagnosis. The study of the amount, effect, and injury of carcinogen with biomarkers has become one of the imporant methods for the early detection for occupational lung cancer.

  7. Bovine tuberculosis in Rwanda: Prevalence and economic impact evaluation by meat inspection at Société des Abattoirs de Nyabugogo-Nyabugogo Abattoir, Kigali.

    Science.gov (United States)

    Habarugira, Gervais; Rukelibuga, Joseph; Nanyingi, Mark O; Mushonga, Borden

    2014-11-05

    Despite the significant public health burden of bovine tuberculosis (bTB) in Rwanda, the prevalence of bTB is poorly documented. This study was conducted to estimate the prevalence of bTB in cattle using gross examination of granulomatous lesions, to identify mycobacteria species in suspected samples, and to evaluate the economic impact of meat condemnation based on bTB-like lesions in the meat industry in Rwanda. Routine meat inspection was conducted at Société des Abattoirs de Nyabugogo (SABAN)-Nyabugogo Abattoir. Tissue samples including 31 lymph nodes, 3 lungs and 2 livers were obtained from cattle of different ages with gross tuberculous lesions. Mycobacterium bovis was identified using microscopy with Kinyoun staining and isolation of mycobacterial species in culture on Löwenstein-Jensen and Colestos media, further identified using biochemical tests. Our findings, based on culture and postmortem results, show that the prevalence of bTB is 0.5%(0.587*148/16753), with an overall gross tuberculous lesion prevalence of 0.9% (148/16753). The presence of lesions were higher in cattle aged 2 years and older (1.6% vs. 0.6%, p Bovine tuberculosis caused condemnation of 1683.5 kg of meat, resulting in an estimated loss of $4810. Our findings indicate that the prevalence of bTB in Rwanda is significant, and that bTB is a major cause of meat condemnation requiring continued implementation of surveillance and control measures. Furthermore, the results from this study also show important variations in sensitivity of the different tests that were used to determine the prevalence of bTB in cattle in Rwanda.

  8. Prevalence of brucella abortus antibodies in bovine serum from gusau modern abattoir, Zamfara state, Nigeria

    Directory of Open Access Journals (Sweden)

    N. Lawal

    2012-10-01

    Full Text Available A study for bovine brucellosis was conducted using serology to determine the status of the disease in slaughtered cattle. Three hundred and twenty (320 sera were collected from Gusau Modern Abattoir, Zamfara State. The sera were tested using Enzyme Linked Immunosorbent Assay obtained from Veterinary Laboratory Agencies, Weybridge, UK. An overall prevalence of 20% (64 positive was obtained with sex prevalence for males and females being 10.62% (34 positive and 9.37% (30 positive respectively out of 180 males and 140 females tested without significant association (P 24 months while; lower prevalence of 3.13% was recorded in age group

  9. Survey on the mortality of malignant tumors in female workers exposed to chrysotile asbestos%接触温石棉女工恶性肿瘤死亡的队列研究

    Institute of Scientific and Technical Information of China (English)

    张幸; 孙统达; 施南峰; 朱丽秋; 森永谦二

    2006-01-01

    目的调查接触温石棉女工的恶性肿瘤死亡率.方法以1960年1月1日至1980年12月31日曾经从事家庭内温石棉手工纺织作业一年以上的女工为调查对象,采用历史性队列流行病学方法进行研究.结果在5 681名接触温石棉纺织女工中,有144名死于癌症,其中有74名女工死于肺癌,病死率最高;其次为肝癌,死亡数为27例;占第三位的是胃癌,死亡数为18例.以当地女性年龄组别恶性肿瘤死亡率均值为对照组计算标准化死亡比(SMR),所有除肺癌外的恶性肿瘤与肺癌的SMR分别为1.16(P<0.05)和4.17(Pworkers exposed to chrysotile asbestos. Methods A retrospective cohort study of female workers was conducted, who had been engaged in the manual spinning of chrysotile in family with more than one year between January 1, 1960 and December 31, 1980. Results A total of 144 persons were found to be dead from cancer. Among them the most frequent was lung cancer (74), and the second liver cancer (27), and the third stomach cancer (18). Standardized mortality ratio (SMR) from total malignant tumor and lung cancer were 1.16 ( P < 0.05) and 4.17 ( P < 0.01 ) respectively, based on the control population of the same region. Conclusion A significant excess death from lung cancer was found among female workers who had been exposed to chrysotile.

  10. 福建省男性健康接尘工人肺通气功能预计值探讨%Study on the reference data of lung function among healthy workers exposed to dust in Fujian province

    Institute of Scientific and Technical Information of China (English)

    梁萌; 梁立徽; 林嗣豪; 魏木水; 谢德兴; 王治国; 陈生枝; 陈启裕; 郑忠武

    2011-01-01

    Objective: To explore the lung function among healthy workers exposed to dust from Fujian province.Methods: Seven hundred and ninty-four healthy workers exposed to dust were involved.Lung function indexes including FVC, FEV1, FEV1/FVC% , V50,V25, MMEF and their prediction percentage were tested by German Yege apparatus.The parameters including age, body height, body weight and employing years were selected as independent variable, and lung function indexes as variable.Multiple regression and percentile were used to analyze the lung function reference data.Results: FVC, FEV1 and FEV1/FVC% were normal in 794 workers exposed to dust.All the lung function indexes were normal among 70% workers.Small airway function V25 and MMEF both declined slightly among 20% workers.V50, V25 and MMEF decreased simultaneously among 10% workers.Lung function was negatively related with age and employing years, positively related with height and weight.The indicator value of airway function decreased with age.This value in 20 ~ 29 years old people, which exceeded the current reference value (0.70 ) , were singinificaly different with those in 40 ~ 49 and 50 ~ 59 years old people (P <0.05).Other values in different age showed no significant difference.FVC and FEV1 were higher than current reference value (0.80) , while MMEF and V50 slightly decreased.Conclusion: Normal reference value of FVC, FEV1 and FEV1/FVC% should increase 0.05 among the workers exposed to dust in Fujian, especially in 20 ~29 years old people.The indexes of airway function, such as MMEF and V50, should both decrease 0.05.It is alert signal that the values of lung function become lower than those mentioned above.%目的:探讨福建省男性健康接尘工人肺通气功能的预计值.方法:选择794名男性健康接尘工人,采用德国耶格肺功能仪,测定FVC、FEV1、FEV1/FVC%,最大呼气中期流速(MMEF)、肺容量50%及肺容量25%时呼气流速(V50、V25),计算实测值占仪

  11. 粉尘作业者呼吸防护用品现场使用情况评价方法构建%Construction of Evaluation in Dust Exposed Workers With Respiratory Protective Equipment Use of Site

    Institute of Scientific and Technical Information of China (English)

    谭晓兵

    2016-01-01

    Objective To investigate the dust exposed workers with respiratory protective equipment use of the site and construction of evaluation.Methods Investigation of respiratory protective equipment for 246 dust exposed workers in an enterprise in three workshop use case,the site and the form of questionnaire survey,on-site construction workers through the analysis of dust comprehensive evaluation of respiratory protective equipment using the method product. Results The respiratory protection plans of the enterprise fails to make the choice,three types of dust workshop operators of respiratory protective equipment,the average monthly payment number change and the success rate of the rate of wear rates were significantly different (P < 0.05),the whole enterprise breath basic protection of the qualified rate was 19.65%,the unqualified rate was 80.35%,the difference was statistical y significant(P<0.05). High KV chest radiograph revealed pneumoconiosis respiratory protective or observation object group qualified rate was significantly lower than control group(P<0.05). Conclusion By constructing a comprehensive evaluation of dust exposed workers respiratory protection products and use method develop respiratory protection plan,effectively regulate the use of respiratory protective equipment,to prevent the occurrence of pneumoconiosis.%目的:探讨粉尘作业者呼吸防护用品现场使用情况且构建评价方法。方法对于某企业3个车间的246名粉尘作业者的呼吸防护用品使用情况进行调查,采用现场及问卷调查的形式,通过构建粉尘作业者呼吸防护用品使用的综合评价方法品进行现场分析。结果显示该企业未制定的呼吸保护计划,3个车间的粉尘作业者呼吸防护用品的选择类型、月均发放数更换达标率及佩戴率的达标率均具有差异(P<0.05);全企业呼吸防护基本合格率为19.65%,不合格率为80.35%,差异具有统计学意义(P<0.05);高

  12. Mudança significativa do limiar auditivo em trabalhadores expostos a diferentes níveis de ruído Significant auditory threshold shift among workers exposed to different noise levels

    Directory of Open Access Journals (Sweden)

    Flavia Cardoso Oliva

    2011-09-01

    Full Text Available OBJETIVO: Avaliar a audição e a ocorrência de mudança significativa do limiar auditivo em trabalhadores de frigoríficos expostos a níveis de ruído abaixo das Normas e Regulamentações nacionais e internacionais e compará-los com trabalhadores expostos a níveis de ruído considerados excessivos. MÉTODOS: Utilizou-se um banco de dados contendo informações longitudinais de 266 trabalhadores. Foram selecionados trabalhadores com um mínimo de três exames audiométricos e os que continham dados de exposição ao ruído. Foram mantidos 63 exames, classificados de acordo com sua exposição ao ruído em três níveis: 79 a 84,9 dB(A, 85 a 89,9 dB(A e 90 a 98,8 dB(A. Foi avaliada a ocorrência de perdas auditivas e de mudança significativa de limiar auditivo dos participantes de cada subgrupo. RESULTADOS: Verificou-se diferenças em todas as frequências nos testes de comparação entre a média dos limiares auditivos para cada frequência em função do nível de exposição ao ruído. A correlação entre a ocorrência de Perda Auditiva Induzida por Níveis de Pressão Sonora Elevados (PAINPSE e os anos de exposição ao ruído dentro da empresa atual foi significativa (R=0,373; p=0,079. Foram encontradas mudanças permanentes de limiar auditivo nos três níveis de exposição ao ruído. CONCLUSÃO: Os achados do presente estudo sugerem a existência de uma associação entre mudança significativa do limiar auditivo dos trabalhadores e os anos de exposição ao ruído considerado de baixo risco.PURPOSE: To assess the hearing status and signs of significant auditory threshold shifts in meat-processing facility workers who are exposed to noise levels below nationally and internationally recommended exposure limits, and to compare these results with data from workers exposed to excessive noise levels. METHODS: Longitudinal audiometric data from 266 workers were evaluated, and only workers with a minimum of three audiometric test results

  13. Biomonitoring of rural workers exposed to a complex mixture of pesticides in the municipalities of Tianguá and Ubajara (Ceará state, Brazil): genotoxic and cytogenetic studies.

    Science.gov (United States)

    Paiva, Jean C G; Cabral, Igor O; Soares, Bruno M; Sombra, Carla M L; Ferreira, José R O; Moraes, Manoel O; Cavalcanti, Bruno C; Pessoa, Cláudia

    2011-07-01

    In recent years, the use of pesticides in agriculture has been steadily increasing, and associations between exposure to agricultural chemicals and DNA damage and cancer have been reported. Brazil is one of the world leaders in pesticide use; however, studies that evaluate the impact of pesticide exposure on cancer incidence and mortality are very scarce in the Brazilian population. The alkaline comet assay and the chromosome aberration (CA) test were used to evaluate primary DNA damage in the peripheral blood lymphocytes of workers exposed to a complex mixture of pesticides in two small rural communities in the municipalities of Tianguá and Ubajara, located in the western part of Ceará State (Northeast Brazil), which are among the largest agricultural areas of the state. The comet assay showed that the damage index and damage frequency observed in the exposed groups were significantly higher in relation to the controls (P < 0.05). On the other hand, no differences were detected regarding structural and numerical CAs in the communities evaluated. Additionally, the observed levels of DNA strand breaks and frequencies of CAs, stratified for exposure time, were not statistically different for individuals of either rural community. Our results suggest that the damages caused by pesticides in our study area were not great enough to induce permanent mutations or to interfere with mitotic apparatus formation; minimal pesticide damages could have undergone cellular repair, explaining the absence of structural and numerical CAs.

  14. Analysis on occupational hearing loss of noise-exposed workers in an aircraft maintenance engineering company%某飞机维修工程公司噪声作业人员听力损伤分析

    Institute of Scientific and Technical Information of China (English)

    张君

    2013-01-01

    [Objective]To investigate the noise-exposed workers in an aircraft maintenance engineering company, to analyze their hearing impairment status, and put forward suggestions for prevention of occupational hearing loss and occupational noise deafness. [Methods] A total of 1 067 noise-exposed workers were recruited as noise group and 111 without noise exposure as control group. MM-622 pure tone audiometer by the zero-level correction was adopted for pure tone air conduction checks at 0.5, 1.0, 2.0, 3. 0, 4.0, 6.0 kHz on ears of workers. Assessment standards of hearing impairment: speech frequency at 0. 5, 1.0, 2.0 kHz in average >25dB, high-frequency at 3.0, 4.0, 6.0 kHz respectively ≥30 dB. [Results] A total of 1 067 workers (2 134 ears) were investigated, 345 (647 ears) had hearing impairment, the prevalence was 32. 33% . High-frequency hearing loss occurred on 320 workers (614 ears) , speech frequency hearing loss on 25 workers (33 ears). Of 111 workers in control group, 4 workers (6 ears) had hearing impairment, all were high-frequency hearing loss, the prevalence was 3. 60%. The prevalence of hearing impairment of noise group was obviously higher than that of control group, with significant difference ( x2 = 39. 80,P <0.01). [Conclusion] Noise influences the high-frequency hearing threshold of workers with exposure . And the risk of hearing loss rate inceases with the extending of service length. It is suggested to strengthen personal protection, to establish health records and control occupational noise deafness.%目的 对某飞机维修工程公司噪声作业人员进行调查,分析该公司噪声作业人员的听力损伤现状,以期对预防职业性听力损伤和职业性噪声聋提出建议.方法 设噪声作业组1067人,非噪声接触人员111人为对照组,均使用丹麦产MM-622型纯音听力计(经零级校正),对两组人员双耳0.5、1.0、2.0、3.0、4.0、6.0 kHz的纯音气导进行检查,听力损伤的评定标准:语频听损以0

  15. A retrospective study of the prevalence of bovine fasciolosis at major abattoirs in Botswana.

    Science.gov (United States)

    Mochankana, M Ernest; Robertson, Ian D

    2016-01-01

    A retrospective study covering a period of ten years (2001-2010) was conducted using postmortem meat inspection records of the Department of Veterinary Services in Gaborone to determine the prevalence of bovine fasciolosis in Botswana. Meat inspection records of monthly and annual returns from the two main export abattoirs in the country were examined, as well as the data collected on the total number of cattle slaughtered and the number of livers condemned due to Fasciola gigantica infection. Only 1250 of the approximately 1.4 million cattle slaughtered were infected with F. gigantica (0.09%, 95% confidence intervals [CI] 0.0% - 0.3%). No distinct seasonal pattern was observed in condemnation rates of livers. However, the pattern of distribution of fasciolosis was higher (but not significant) in cattle that originated from areas with high rainfall and more permanent water bodies than those from relatively low rainfall areas with a transitory water system. It is recommended that a longitudinal survey should be carried out at the abattoirs and farms to determine the prevalence of the disease in cattle of different ages, sex and breed as well as the place of origin in the country. The present study indicated that the prevalence of fasciolosis in cattle is low and the disease is therefore of less significance in Botswana than other African countries for which information is available. PMID:27380655

  16. Molecular characterization of Mycobacterium bovis strains isolated from cattle slaughtered at two abattoirs in Algeria

    Directory of Open Access Journals (Sweden)

    Ouzrout Rachid

    2009-01-01

    Full Text Available Abstract Background Bovine Tuberculosis is prevalent in Algeria despite governmental attempts to control the disease. The objective of this study was to conduct, for the first time, molecular characterization of a population sample of Mycobacterium bovis strains isolated from slaughter cattle in Algeria. Between August and November 2007, 7250 animals were consecutively screened at the abattoirs of Algiers and Blida. In 260 animals, gross visible granulomatous lesions were detected and put into culture. Bacterial isolates were subsequently analysed by molecular methods. Results Altogether, 101 bacterial strains from 100 animals were subjected to molecular characterization. M. bovis was isolated from 88 animals. Other bacteria isolated included one strain of M. caprae, four Rhodococcus equi strains, three Non-tuberculous Mycobacteria (NTM and five strains of other bacterial species. The M. bovis strains isolated showed 22 different spoligotype patterns; four of them had not been previously reported. The majority of M. bovis strains (89% showed spoligotype patterns that were previously observed in strains from European cattle. Variable Number of Tandem Repeat (VNTR typing supported a link between M. bovis strains from Algeria and France. One spoligotype pattern has also been shown to be frequent in M. bovis strains from Mali although the VNTR pattern of the Algerian strains differed from the Malian strains. Conclusion M. bovis infections account for a high amount of granulomatous lesions detected in Algerian slaughter cattle during standard meat inspection at Algiers and Blida abattoir. Molecular typing results suggested a link between Algerian and European strains of M. bovis.

  17. The slaughter of increased numbers of pregnant cows in Tanga abattoir, Tanzania: A cause for concern?

    Directory of Open Access Journals (Sweden)

    Emmanuel S. Swai

    2015-02-01

    Full Text Available Information on the level of foetal wastage in slaughtered cattle in Tanzania is limited. A three-month observational study (April – June 2014 of animals slaughtered at the Tanga abattoir in Tanga region, Tanzania was carried out to determine the number of pregnant cows slaughtered. The total number of cattle slaughtered during the study period was 3643, representing a monthly kill average of 1214 and a daily kill average of 40. Over 98% of the cattle presented to the abattoir for slaughter were local breed (Tanzania shorthorn zebu and most were above 3 years of age. Improved breeds of cattle represented only 1.3% of all slaughters. Of the cattle slaughtered, 2256 (61.9% were female and 1387 (38.1% were male. A total of 655 slaughtered cows were pregnant, representing a foetal wastage of 29.1%. Of the 655 recovered foetuses, 333 (50.8% were male and 322 (49.2% were female. Of the recovered foetuses, 25.8% were recovered in the first, 42.7% in the second and 31.6% in the third trimester. This study indicates cases of significant foetal losses, negatively impacting future replacement stock as a result of the slaughter of pregnant animals. The indiscriminate slaughter of pregnant cows suggests that existing animal welfare legislation is not sufficiently enforced and routine veterinary ante-mortem inspection of trade animals is failing to prevent the high level of foetal wastage.

  18. 某陶瓷厂噪声作业工人听力损失的调查分析%Investigation on the hearing loss of workers exposed to noise in a ceramic plant

    Institute of Scientific and Technical Information of China (English)

    邓雪凝; 陈伟波; 杜翠婵; 徐娜; 何凤平; 陈健安

    2012-01-01

    目的 研究陶瓷厂噪声对作业人员听力的影响.方法 采用丹麦GST-68型纯音听力计,测定82例接触噪声工人(噪声组)和48例非接触噪声工人(对照组)的听力.结果 测定18个噪声点,噪声强度平均(85.7±6.6)dB(A)[71.4~95.2 dB(A)],其中有15个点超标,超标率88.3%.噪声组听力损失检出率51.22%,明显高于对照组(10.42%),差异有极显著性(P<0.01).接触噪声工龄<3年、3~5年、>6年组听力损失检出率分别为16.67%、77.14%和81.82%,听力损失检出率随接触噪声工龄的增加而升高,差异有极显著性(P<0.01).结论 陶瓷企业噪声引起作业工人听力损失,应做好预防工作.%Objective To study the effect of noise to the hearing loss of the workers exposed to noise in a ceramic plant.Methods The hearing examination in 82 noise exposed workers (noise exposed group) in a ceramic plant and 48 non-exposed personnel (control group) were determined by model GST-68 pure tone audiometer made in Denmark.Results 18 points of noise intensities were detected and average noise intensity was( 85.7 ± 6.6 )dB(A) and 15 points (88.3%) exceeded the national occupational exposure limits.The incidence rate of hearing loss in the noise exposed group was 51.22%,significantly higher than that in control group (10.42%,P<0.01).The duration of noise exposure < 3 years,3years ~ 6 years、> 6 years were 16.67%,77.14% and 81.82% respectively.The incidence rate of hearing loss seemed to be increased gradually with duration of noise exposure increasing ( P<0.01 ).Coneluusion The hearing loss abnormality could be caused by exposure to noise in the ceramic enterprises,precautions and measurements should be implemented.

  19. 工频电磁场作业人员周围血淋巴细胞微核分析%Analysis on micronucleus of peripheral blood lymphocytes in workers exposed to power frequency electromagnetic fields

    Institute of Scientific and Technical Information of China (English)

    李丽; 陈慧峰; 李华亮; 黎丽春; 曾广诚; 陈建雄; 温薇; 闫雪华

    2016-01-01

    Objective To examine the effects of long-term exposure to power frequency electromagnetic fields on the occurrence of micronucleus in peripheral blood lymphocytes and the lymphocyte transformation in transformer substation workers .Methods By simple random sampling method , 54 workers exposed to power frequency electromagnetic fields for more than 1.0 year and other 54 non-exposure workers in 500 kV transformer substations were chosen as the exposure group and control group, respectively.The peripheral venous blood of subjects in these two groups was collected , and then the lymphocytes were separated .The micronucleus cell rate , the micronucleus rate and the lymphocyte transformation rate were detected and analyzed .Results Compared with the control group , the micronucleated cell rate , the micronucleus rate , and the lymphocyte transformation rate of the exposure group and its different length of service subgroups (≤10.0 and >10.0 years) showed no statistical significance respectively ( P>0.05).Conclusion The long-term exposure to power frequency electromagnetic fields has no obvious effects on the micronucleus and lymphocyte transformation in the peripheral blood lymphocytes of exposed workers .%目的:探讨长期接触工频电磁场对变电站作业人员周围血淋巴细胞的微核以及淋巴细胞转化的影响。方法采用单纯随机抽样方法,选择54名工龄1.0年以上的500 kV变电站工频电磁场作业人员为接触组,选择54名同单位无职业性工频电磁场接触的人员为对照组,采集2组人群周围静脉血,提取淋巴细胞,检测微核细胞率、微核率以及淋巴细胞转化率,分析其变化情况。结果与对照组比较,接触组及其工龄≤10.0年亚组和工龄>10.0年亚组人群周围血淋巴细胞的微核细胞率、微核率及淋巴细胞转化率均无出现有统计学意义改变( P>0.05)。结论长期接触工频电磁场对作业人员周围血淋巴细胞

  20. Bovine tuberculosis in Rwanda: Prevalence and economic impact evaluation by meat inspection at Société des Abattoirs de Nyabugogo-Nyabugogo Abattoir, Kigali

    Directory of Open Access Journals (Sweden)

    Gervais Habarugira

    2014-02-01

    Full Text Available Despite the significant public health burden of bovine tuberculosis (bTB in Rwanda, the prevalence of bTB is poorly documented. This study was conducted to estimate the prevalence of bTB in cattle using gross examination of granulomatous lesions, to identify mycobacteria species in suspected samples, and to evaluate the economic impact of meat condemnation based on bTB-like lesions in the meat industry in Rwanda. Routine meat inspection was conducted at Société des Abattoirs de Nyabugogo (SABAN-Nyabugogo Abattoir. Tissue samples including 31 lymph nodes, 3 lungs and 2 livers were obtained from cattle of different ages with gross tuberculous lesions. Mycobacterium bovis was identified using microscopy with Kinyoun staining and isolation of mycobacterial species in culture on Löwenstein–Jensen and Colestos media, further identified using biochemical tests. Our findings, based on culture and postmortem results, show that the prevalence of bTB is 0.5%(0.587*148/16753, with an overall gross tuberculous lesion prevalence of 0.9% (148/16753. The presence of lesions were higher in cattle aged 2 years and older (1.6% vs. 0.6%, p < 0.05 and higher in females than in males (1.4% vs. 0.6%, p < 0.05. Of the 36 samples tested, 26 (72.2% were positive by microscopic examination with Kinyoun staining while M. bovis was culture-confirmed in 21 (58.7% cases. Bovine tuberculosis caused condemnation of 1683.5 kg of meat, resulting in an estimated loss of $4810. Our findings indicate that the prevalence of bTB in Rwanda is significant, and that bTB is a major cause of meat condemnation requiring continued implementation of surveillance and control measures. Furthermore, the results from this study also show important variations in sensitivity of the different tests that were used to determine the prevalence of bTB in cattle in Rwanda.

  1. Performance of biomarkers SMRP, CA125, and CYFRA 21-1 as potential tumor markers for malignant mesothelioma and lung cancer in a cohort of workers formerly exposed to asbestos

    International Nuclear Information System (INIS)

    The aim of the study is to examine the cancer-predictive values of SMRP (soluble mesothelin-related peptides), CA125, and CYFRA21-1 as potential tumor markers for lung cancer and malignant mesothelioma in a cohort of workers formerly exposed to asbestos. A voluntary surveillance program has been established for German workers with former asbestos exposure. A subgroup of 626 subjects with a mean age of 63 years (range 53-70 years) at baseline was enrolled in an extended health examination program with high-resolution computer tomography (HRCT) of the chest and blood drawing between 1993 and 1997. Serum concentrations of SMRP, CA125, and CYFRA21-1 were measured in archived serum samples in 2005 and 2006. A mortality follow-up was conducted through 2007. So far, 12 cases with lung cancer and 20 cases with malignant mesothelioma have been observed in this cohort. The average time between sample collection and diagnosis was 4.7 years. Analyzed biomarkers showed low sensitivities (5-25%) and positive predictive values (4-30%) for both cancer sites. Marker combinations resulted in sensitivities between 5 and 50% and positive predictive values ranging from 3 to 14%. Even in those cases, where biomarker concentrations were available within 36 months before diagnosis, no trend for increasing biomarker levels was observed. The analyzed tumor markers were characterized by high specificities, but low sensitivities. SMRP, CA125, and CYFRA21-1 alone or in combination were less suitable to serve as predictors for the diagnosis of lung cancer or malignant mesothelioma. However, a prospective study with annual sampling might reveal a better predictive value of these markers. (orig.)

  2. Performance of biomarkers SMRP, CA125, and CYFRA 21-1 as potential tumor markers for malignant mesothelioma and lung cancer in a cohort of workers formerly exposed to asbestos

    Energy Technology Data Exchange (ETDEWEB)

    Gube, M. [RWTH Aachen University, Institute for Occupational and Social Medicine, Medical Faculty, Aachen (Germany); Westfaelische Technische Hochschule, Institut fuer Arbeitsmedizin und Sozialmedizin am Universitaetsklinikum Aachen, Rheinisch, Aachen (Germany); Taeger, D.; Weber, D.G.; Pesch, B.; Johnen, G.; Gross, I.M.; Wiethege, T.; Weber, A.; Bruening, T. [Institute of the Ruhr-Universitaet Bochum (IPA), Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Bochum (Germany); Brand, P.; Mueller-Lux, A.; Kraus, T. [RWTH Aachen University, Institute for Occupational and Social Medicine, Medical Faculty, Aachen (Germany); Raithel, H.J. [University of Erlangen-Nuremberg, Institute for Occupational, Social and Environmental Medicine, Erlangen-Nuremberg (Germany)

    2011-03-15

    The aim of the study is to examine the cancer-predictive values of SMRP (soluble mesothelin-related peptides), CA125, and CYFRA21-1 as potential tumor markers for lung cancer and malignant mesothelioma in a cohort of workers formerly exposed to asbestos. A voluntary surveillance program has been established for German workers with former asbestos exposure. A subgroup of 626 subjects with a mean age of 63 years (range 53-70 years) at baseline was enrolled in an extended health examination program with high-resolution computer tomography (HRCT) of the chest and blood drawing between 1993 and 1997. Serum concentrations of SMRP, CA125, and CYFRA21-1 were measured in archived serum samples in 2005 and 2006. A mortality follow-up was conducted through 2007. So far, 12 cases with lung cancer and 20 cases with malignant mesothelioma have been observed in this cohort. The average time between sample collection and diagnosis was 4.7 years. Analyzed biomarkers showed low sensitivities (5-25%) and positive predictive values (4-30%) for both cancer sites. Marker combinations resulted in sensitivities between 5 and 50% and positive predictive values ranging from 3 to 14%. Even in those cases, where biomarker concentrations were available within 36 months before diagnosis, no trend for increasing biomarker levels was observed. The analyzed tumor markers were characterized by high specificities, but low sensitivities. SMRP, CA125, and CYFRA21-1 alone or in combination were less suitable to serve as predictors for the diagnosis of lung cancer or malignant mesothelioma. However, a prospective study with annual sampling might reveal a better predictive value of these markers. (orig.)

  3. Study on risk factors of blood lead among occupational workers exposed to lead%职业性铅暴露人群血铅的危险因素研究

    Institute of Scientific and Technical Information of China (English)

    苗超; 邵迪初

    2012-01-01

    Objective To study the risk factors of blood lead among workers who exposed to lead and provide scientific evidence for the establishment of its control and prevention. Methods A total of 227 workers in accumulator plants were selected as study objects. Their professional history, life habits and the level of education were investigated by uniformly designed questionnaire. The workers' blood lead and the lead concentration in air in their job-sites were measured. Risk factors of blood lead were analyzed by means of simple and multiple conditional logistic regression analysis. Results A total of 29 test sites were monitored, only 5 sites were qualified, the rate was 17. 24%. The mean of blood level of workers was (578. 54± 175. 56) μg/L. Simple logistic regression analysis showed that gender, smoking, residence, educational level and workplace air concentrations of lead could affect blood lead concentrations. Multiple conditional logistic regression analysis showed that workplace air concentrations of lead and residence could significantly affect blood lead concentrations. Conclusions Workplace air concentrations of lead is higher than the standard. The workers usually have the high level of blood lead. Workplace air concentrations of lead and residence are risk factors of blood lead.%目的 探讨职业铅暴露人群血铅的危险因素,为采取针对性的防控措施提供科学依据.方法 选择余姚市蓄电池工厂227名工人作为研究对象,采用统一调查表对个人职业史、生活习惯、教育程度等进行调查,同时进行血铅和车间空气中铅浓度测定.在此基础上,分别采用单因素、多因素条件logistic回归分析筛选血铅的关联因素,P<0.05为差异有统计学意义.结果 本研究共设29个检测点,仅5个点合格,合格率17.24%,工人平均血铅水平为(578.54±175.56)μg/L.单因素条件logistic回归分析显示性别、吸烟、户籍、文化程度和车间空气铅浓度等变

  4. 铅作业工人血铅、尿铅和锌原卟啉测定结果分析%Results analysis of blood lead , urine lead and zinc protoporphyrin determination in workers exposed to lead

    Institute of Scientific and Technical Information of China (English)

    盛红艳

    2012-01-01

    目的 比较铅作业工人和非铅作业工人血铅、尿铅浓度、红细胞锌原卟啉和血常规的差异,探讨铅作业工人红细胞锌原卟啉和血铅、尿铅浓度的相关性.方法 以蓄电池企业的252名铅作业工人作为接铅组,电子厂205名非铅作业工人作为对照组,测定血铅、尿铅浓度、红细胞锌原卟啉和血常规,并对结果进行统计学处理.结果 接铅组血红蛋白含量低于对照组(P<0.05),白细胞和红细胞、血小板则无差异(P>0.05),接铅组红细胞锌原卟啉、血铅、尿铅浓度均显著高于对照组(P<0.01),尿铅与红细胞锌原卟啉的相关系数(r) =0.166,血铅与红细胞锌原卟啉的相关系数r=0.406.结论 长期接触铅可导致血铅、尿铅浓度和红细胞锌原卟啉升高,血红蛋白降低,对白细胞、红细胞、血小板无明显影响,血铅与红细胞锌原卟咻的相关性较尿铅与红细胞锌原卟啉的相关性好.%[ Objective] To compare the differences of blood lead , urine lead and zinc protoporphyrin determination between workers with lead exposure and workers without lead exposure, and explore the correlation ? between erythrocyte zinc protoporphyrin and blood lead level, urine lead level of workers. [ Methods] A total of 252 lead exposed workers from a storage battery manufacture were selected as lead exposure group, another 205 workers without lead exposure from a electronics Factory as control group. The determination of blood lead level, urinary lead level, erythrocyte zinc protoporphyrin and blood routine examination were performed, and the results were statistically analyzed. [ Results] Hemoglobin content of lead exposure group was significantly lower than that of control group (P<0.05) , while leukocytes, erythrocytes and blood platelet were not significantly different (P>0.05). Erythrocyte zinc protoporphyrin , blood lead , urinary lead concentration of lead exposure group were higher than those of control

  5. Enterprise Shipbuilding Workers Exposed to Noise Analysis Results of Pure Tone Audiometry%某造船企业噪声作业工人纯音测听结果分析

    Institute of Scientific and Technical Information of China (English)

    张志雄; 高盛庭; 蒋朝利

    2014-01-01

    目的:探讨生产性噪声对作业工人听力的影响。方法对某造船企业94名噪声作工人进行在岗期间纯音电测听检查,测听数据进行统计分析。结果听力损失37人(占受检人数的39.36%),其中轻度听力损失36人,中度听力损失1人。听力损失随工龄增加而升高,不同工龄组间听力损失比较有统计学意义(P<0.05)。结论听力损失随接触噪工龄的增加呈上升趋势。建议企业加强监督和管理,做好作业工人职业危害宣传教育和个人防护,建立和完善职业健康监护档案,控制职业性噪声聋发生。%Objective To investigate the ef ects of noise on workers productive hearing. Methods Pure tone audiometry examination for 94 shipyard workers during the post, Statistical analysis for audiometric data. Results 37 of hearing loss (accounting for 39.36%the number of subjects), in which 36 people with mild hearing loss and 1 person with moderate hearing loss.Hearing loss increases with length of service The comparasion among dif erent working-age groups was statistical y significant ( <0.05). Conclusion Hearing loss increases with the exposure to noise seniority on the rise. Recommend that companies strengthen supervision and management, good education and personal protection for the workers exposed to occupational hazards, establish and improve occupational health record, prevent occupational noise deafness occuring.

  6. Preliminary investigation and analysis on the health effects of workers exposed to nano calcium carbonate%纳米碳酸钙对作业人群健康影响初步调查分析

    Institute of Scientific and Technical Information of China (English)

    梁丽红; 陈嘉斌; 黄汉林; 黄振烈; 蒙得志; 阮小林; 董明; 杨展鸿; 赖关朝; 黄伟欣; 杨爱初

    2014-01-01

    Objective To assess the exposure levels of nano-calcium carbonate ( CaCO3 ) in workplace and the health effect on workers exposed to nano-CaCO3 in the production enterprise .Methods According to cluster sampling , 35 workers exposed to nano-CaCO3 in a nano-CaCO3 production enterprise and 35 workers without dust and toxicant exposure in a pu blic institution were chosen as the exposed group and the control group respectively .The two groups were well matched in age and length of service ( exposed ∶control =1∶1 ) .Particle counting level and time weighted average concentration (CTWA) of nano-CaCO3 were detected in the workplace of the exposed group , and the accumulated CTWA level of nano-CaCO3 were calculated .Health examination was conducted and the health status was compared to the two groups .Dose-effect relationship between pulmonary ventilation hypofunction and exposed level of nano -CaCO3 in the exposed group was analyzed.Results The median of particle counting level and CTWA of nano-CaCO3 were 15 716 particles/cm3 and 2.419 mg/m3 respectively .Packaging post showed the highest levels both in the above two detecting indexes .The rates of pulmo-nary ventilation hypofunction in the exposed group was higher than that in the control group (57.1%vs 5.7%, P0.05).In accordance with the including criteria and exclusive criteria of the independent variables standards were 0.10 and 0.15, respectively, Logistic regression analysis showed dose-effect relationship between the pulmonary venti-lation hypofunction and the accumulation CTWA level of nano-CaCO3 after adjustment by gender , age, smoking and drinking (odds ratio:2.74, 95%confidence interval:0.88-8.56, P=0.08).Conclusion Exposure to nano-CaCO3 can reduce lung ventilation function , induce immune response and change electrolytes .Pulmonary function tests could be used as a physical examination project in the workers exposed to nano-CaCO3 .%目的:了解纳米碳酸钙生产企业工作场所纳米碳酸钙

  7. Comparative investigation of hearing inj ury in workers exposed to steady and non-steady state noise%稳态噪声与非稳态噪声对工人听力损伤的对比研究

    Institute of Scientific and Technical Information of China (English)

    陆春花; 杨继红; 沙磊; 陈杰; 尹仕伟

    2014-01-01

    目的:对稳态噪声与非稳态噪声导致的工人听力损伤进行对比分析。方法将某船厂组立车间和内业车间的96名接触非稳态噪声的工人作为非稳态噪声接触组,将某织布厂的96名接触稳态噪声的捻丝、假捻丝和织布工人作为稳态噪声接触组。用个人声暴露计采集工作期间噪声暴露数据,计算40 h等效声级(LEX,周)和累积噪声暴露量(CNE)。按 GBZ 49-2007《职业性噪声聋诊断标准》对两组工人进行听力测试,并计算和判定结果。结果非稳态噪声组CNE 为(100.3±2.1)dB(A)·a,稳态噪声组 CNE 为(99.6±4.3)dB(A)·a,两组比较,差异无统计学意义(P>0.05)。非稳态噪声组高频听力损伤率达17.7%,稳态噪声组高频听力损伤率达20.8%,差异无统计学意义(P>0.05)。非稳态噪声组与稳态噪声组组内不同工种组间CNE比较,差异均有统计学意义(P0.05)was found.But there were differences of CNE among different types of work in both groups(P<0.05).Conclusions When the exposure levels of workers were similar,there was no difference of the hearing inj ury in workers exposed to non-steady state noise or group exposed to steady state noise.

  8. An abattoir survey of contagious bovine pleuropneumonia lesions in slaughtered cattle in selected districts in Northern Tanzania

    Institute of Scientific and Technical Information of China (English)

    Emmanuel Swai; Isidory Mwezimpya; Edward Ulicky; Adam Mbise; Winford Moshy

    2013-01-01

    Objective: To establish and estimate incidence of contagious bovine pleuropneumonia (CBPP), using abattoir survey as a diagnostic tool in slaughtered cattle in Northern Tanzania. Methods:A total of 4 460 cattle were slaughtered in five abattoirs in 3 northern zone regions (Arusha, Kilimanjaro and Tanga) during the period of January to May 2004. They were examined ante-mortem for ‘pneumonia signs’, and ‘characteristic contagious bovine pleuropneumonia (CBPP) lung lesions’. Results: Forty-one (0.91%) of the slaughtered cattle, the majority of which were Tanzania short horn zebu, had gross lung lesions suggestive of CBPP. The prevalence of lesions was significantly (P<0.05) higher in Karatu abattoir compared to others. No animal was detected to have lesion in Bomang’ ombe abattoir. The most observed pneumonic signs included labored breathing (90%), dry cough (57%) and mucopurulent nasal discharge (47%). The gross characteristic CBPP pathological lesion, frequently encountered was left lung lesion (47%), pinkish lung (71%) and pleural adhesion (98%). Epidemiological reports show that the CBPP reported outbreaks increased from 19 in 2002, 65 in 2003 and 18 in 2004 (January-March). The corresponding number of reported deaths increased from 137 in 2002, 269 in 2003 and 77 in 2004 (January-March). Conclusions: It’s concluded from this study that CBPP is a problem in spite of the extensive awareness and vaccination campaigns. Nevertheless, a continued surveillance programme including routine checks of all cattle carcasses at the abattoir and subsequent epidemiological investigation of suspected cases are recommended.

  9. An abattoir survey of contagious bovine pleuropneumonia lesions in slaughtered cattle in selected districts in Northern Tanzania

    Institute of Scientific and Technical Information of China (English)

    Emmanuel; Swai; Isidory; Mwezimpya; Edward; Ulicky; Adam; Mbise; Winford; Moshy

    2013-01-01

    Objective:To establish and estimate incidence of contagious bovine pleuropneumonia(CBPP),using abattoir survey as a diagnostic tool in slaughtered cattle in Northern Tanzania.Methods:A total of 4460 cattle were slaughtered in five abattoirs in 3 northern zone regions(Arusha,Kilimanjaro and Tanga)during the period of January to May 2004.They were examined ante-mortem for‘pneumonia signs’,and‘characteristic contagious bovine pleuropneumonia(CBPP)lung lesions’.Results:Forty-one(0.91%)of the slaughtered cattle,the majority of which were Tanzania short horn zebu,had gross lung lesions suggestive of CBPP.The prevalence of lesions was significantly(P<0.05)higher in Karatu abattoir compared to others.No animal was detected to have lesion in Bomang’ombe abattoir.The most observed pneumonic signs included labored breathing(90%),dry cough(57%)and mucopurulent nasal discharge(47%).The gross characteristic CBPP pathological lesion,frequently encountered was left lung lesion(47%),pinkish lung(71%)and pleural adhesion(98%).Epidemiological reports show that the CBPP reported outbreaks increased from 19 in 2002,65 in 2003 and 18 in 2004(January-March).The corresponding number of reported deaths increased from 137 in 2002,269 in 2003 and 77 in 2004(January-March).Conclusions:It’s concluded from this study that CBPP is a problem in spite of the extensive awareness and vaccination campaigns.Nevertheless,a continued surveillance programme including routine checks of all cattle carcasses at the abattoir and subsequent epidemiological investigation of suspected cases are recommended.

  10. 工频电磁场对作业人员淋巴细胞亚群影响研究%Study on changes of lymphocyte subpopulation in workers exposed to power frequency electromagnetic fields

    Institute of Scientific and Technical Information of China (English)

    陈慧峰; 李丽; 闫雪华; 李华亮; 黎丽春; 王汉钦; 温薇; 李荣宗; 李小亮

    2014-01-01

    Objective To investigate the effects of power frequency electromagnetic fields on peripheral blood lymphocyte subpopulation in the long-term exposed workers .Methods Ninety-four workers exposed to power frequency electromagnet-ic fields and eight-six non-exposed workers ( administrative and logistics staffs ) from 10 of 500 kV transformer substations in a certain province were chosen as the exposure group and control group , respectively by simple random sampling .Pe-ripheral venous blood of two groups was collected , and then the percentages of lymphocyte subpopulations including T lym -phocyte, B lymphocyte and natural killer cell (NK cell) were detected and analyzed by flow cytometry .Results The T lymphocyte percentages were ( 66.62 ±9.85 )% and ( 67.98 ±9.36 )%, B lymphocyte percentages were ( 10.67 ± 4.42)%and (11.41 ±3.99)%, NK cells percentages were (21.88 ±10.22)%and (19.64 ±9.42)%, respectively, in exposure and control groups .No statistical significant difference were found in T , B lymphocyte and NK cells percenta-ges between the exposure and non-exposure groups ( P>0.05 ) .The results of multiple linear regression analysis demon-strated that both the power frequency electromagnetic fields exposure and length of service did not have significant effects on the percentages of T lymphocyte , B lymphocyte and NK cells after adjustment for confounding factors such as gender , age, alcohol drinking, tea drinking, smoking, medical exposure and stressful events (P>0.05).Conclusion Long-term ex-posure to power frequency electromagnetic fields has no obvious effects on percentages of peripheral blood lymphocyte sub -population in exposed workers .%目的:探讨长期工频电磁场接触对作业人员的周围血淋巴细胞亚群的影响。方法采用单纯随机抽样方法,选择某省10座500 kV变电站长期接触工频电磁场的94名作业人员为接触组,86名不接触工频电磁场的行政及后勤人员为对照组。采集2组人

  11. 某机械厂454名噪声作业工人听力状况的调查%Investigation on hearing status of 454 noise-exposed workers in a machinery factory

    Institute of Scientific and Technical Information of China (English)

    姚春凤

    2013-01-01

    目的 了解某机械厂噪声作业工人听力下降的情况,并探讨其影响因素.方法 对某机械厂454名噪声作业人员的职业健康检查资料结合作业场所噪声监测报告进行统计分析.结果 高频听力异常137人,占受检人数的30.18%;听力下降随工龄增加而增高,不同工龄组间高频听力下降率比较,差异有统计学意义(P<0.01);听力下降在男女之间存在明显差异(x2=27.87,P<0.01);工作场所噪声强度与听力下降间有明显的相关性.结论 生产性噪声对高频听力有影响,并随噪声作业工龄、工作场所噪声强度的增加,听力下降的危险性也明显增加;不良的生活习惯可增加听力下降的危险性.建议加强个人防护,改善工艺,降低噪声强度,同时应注意改变个人的不良生活习惯,控制噪声聋的发生.%[Objective]To investigate the hearing loss status of workers exposed to noise and its influencing factors in a machinery factory. [Methods]Data from occupational health examinations on 454 workers exposed to noise in a machinery factory and noise surveillances at their working sites were included for analysis. [Results] Among those workers, 137 individuals (30. 18% ) had high-frequency hearing loss which was increased with extending length of service. The difference was significant (P <0.01). The prevalence of hearing loss was significantly different between genders (χ2 = 27. 87 ,P <0. 01). Intensity of noise at working sites was significantly associated with hearing loss. [Conclusion]Industrial noise impacts high-frequency hearing capacity. The risk of getting hearing loss can increase with extending of service length, increasing intensity of noise. Unhealthy lifestyles can aggravate its degree. Improved individual protections, advanced techniques, lower intensity of noise are strongly suggested. Meanwhile, unhealthy lifestyles should be changed as well to control hearing loss induced by noise. Key words

  12. Prevalence and risk factors for Salmonella in veal calves at Danish cattle abattoirs

    DEFF Research Database (Denmark)

    Nielsen, L. R.; Baggesen, Dorte Lau; Aabo, Søren;

    2011-01-01

    The study's objectives were to determine herd- and animal-level prevalence and herd-level risk factors for Salmonella in dairy-bred veal calves at slaughter in Denmark. In total, 1296 faecal samples were collected at five cattle abattoirs in Denmark during 2007 2008. The animals came from 71...... randomly selected specialized veal-calf producers that delivered more than 100 animals to slaughter per year. Salmonella Dublin bacteria were isolated from 19 samples from 12 herds and Salmonella Typhimurium was isolated from one sample. The apparent prevalence of herds delivering Salmonella......-shedding animals to slaughter was 18% (95% CI 9-27). The overall estimated true prevalence of shedding calves at slaughter was 1.3%. Veal-calf herds that purchased animals from herds not classified as low risk in the Danish Salmonella surveillance programme had significantly (P = 0.03) higher risk of delivering...

  13. Effect of industrial waste products on phosphorus mobilisation and biomass production in abattoir wastewater irrigated soil.

    Science.gov (United States)

    Seshadri, Balaji; Kunhikrishnan, Anitha; Bolan, Nanthi; Naidu, Ravi

    2014-09-01

    This study evaluated the effect of alkaline industrial by-products such as flyash (FA) and redmud (RM) on phosphorus (P) mobilisation in abattoir wastewater irrigated soils, using incubation, leaching and plant growth (Napier grass [Pennisetum purpureum]) experiments. The soil outside the wastewater irrigated area was also collected and treated with inorganic (KH2PO4 [PP]) and organic (poultry manure [PM]) P treatments, to study the effect of FA and RM on P mobilisation using plant growth experiment. Among the amendments, FA showed the highest increase in Olsen P, oxalic acid content and phosphatase activity. The highest increase in Olsen P for PM treated non-irrigated soils showed the ability of FA and RM in mobilising organic P better than inorganic P (PP). There was over 85 % increase in oxalic acid content in the plant growth soils compared to the incubated soil, showing the effect of Napier grass in the exudation of oxalic acid. Both amendments (FA and RM) showed an increase in phosphatase activity at over 90 % at the end of the 5-week incubation period. The leaching experiment indicated a decrease in water soluble P thereby ensuring the role of FA and RM in minimising P loss to water bodies. FA and RM showed an increase in plant biomass for all treatments, where FA amended soil showed the highest increase as evident from FA's effect on Olsen P. Therefore, the use of FA and RM mobilised P in abattoir wastewater irrigated soils and increased biomass production of Napier grass plants through root exudation of oxalic acid. PMID:24862480

  14. Pig Abattoir Inspection Data: Can It Be Used for Surveillance Purposes?

    Science.gov (United States)

    Correia-Gomes, Carla; Smith, Richard P; Eze, Jude I; Henry, Madeleine K; Gunn, George J; Williamson, Susanna; Tongue, Sue C

    2016-01-01

    Statutory recording of carcass lesions at the abattoir may have significant potential as a resource for surveillance of livestock populations. Food Standards Agency (FSA) data in Great Britain are not currently used for surveillance purposes. There are concerns that the sensitivity of detection, combined with other issues, may make the outputs unreliable. In this study we postulate that FSA data could be used for surveillance purposes. To test this we compared FSA data with BPHS (a targeted surveillance system of slaughtered pigs) and laboratory diagnostic scanning surveillance (FarmFile) data, from mid-2008 to mid-2012, for respiratory conditions and tail bite lesions in pigs at population level. We also evaluated the agreement/correlation at batch level between FSA and BPHS inspections in four field trials during 2013. Temporal trends and regional differences at population level were described and compared using logistic regression models. Population temporal analysis showed an increase in respiratory disease in all datasets but with regional differences. For tail bite, the temporal trend and monthly patterns were completely different between the datasets. The field trials were run in three abattoirs and included 322 batches. Pearson's correlation and Cohen's kappa tests were used to assess correlation/agreement between inspections systems. It was moderate to strong for high prevalence conditions but slight for low prevalence conditions. We conclude that there is potential to use FSA data as a component of a surveillance system to monitor temporal trends and regional differences of chosen indicators at population level. At producer level and for low prevalence conditions it needs further improvement. Overall a number of issues still need to be addressed in order to provide the pig industry with the confidence to base their decisions on these FSA inspection data. Similar conclusions, at national level, may apply to other livestock sectors but require further

  15. Pig Abattoir Inspection Data: Can It Be Used for Surveillance Purposes?

    Science.gov (United States)

    Correia-Gomes, Carla; Smith, Richard P.; Eze, Jude I.; Henry, Madeleine K.; Gunn, George J.; Williamson, Susanna; Tongue, Sue C.

    2016-01-01

    Statutory recording of carcass lesions at the abattoir may have significant potential as a resource for surveillance of livestock populations. Food Standards Agency (FSA) data in Great Britain are not currently used for surveillance purposes. There are concerns that the sensitivity of detection, combined with other issues, may make the outputs unreliable. In this study we postulate that FSA data could be used for surveillance purposes. To test this we compared FSA data with BPHS (a targeted surveillance system of slaughtered pigs) and laboratory diagnostic scanning surveillance (FarmFile) data, from mid-2008 to mid-2012, for respiratory conditions and tail bite lesions in pigs at population level. We also evaluated the agreement/correlation at batch level between FSA and BPHS inspections in four field trials during 2013. Temporal trends and regional differences at population level were described and compared using logistic regression models. Population temporal analysis showed an increase in respiratory disease in all datasets but with regional differences. For tail bite, the temporal trend and monthly patterns were completely different between the datasets. The field trials were run in three abattoirs and included 322 batches. Pearson’s correlation and Cohen’s kappa tests were used to assess correlation/agreement between inspections systems. It was moderate to strong for high prevalence conditions but slight for low prevalence conditions. We conclude that there is potential to use FSA data as a component of a surveillance system to monitor temporal trends and regional differences of chosen indicators at population level. At producer level and for low prevalence conditions it needs further improvement. Overall a number of issues still need to be addressed in order to provide the pig industry with the confidence to base their decisions on these FSA inspection data. Similar conclusions, at national level, may apply to other livestock sectors but require further

  16. Quantitative examination of Salmonella spp. in the lairage environment of a pig abattoir.

    Science.gov (United States)

    Boughton, Claire; Egan, John; Kelly, Gabrielle; Markey, Bryan; Leonard, Nola

    2007-01-01

    One of the initial sources of Salmonella spp. and other bacterial pathogens at the abattoir is the carrier pig. In the absence of effective cleaning and disinfection measures, such animals may contaminate the lairage environment, which may act as a significant source of infection for incoming non-infected animals. The objectives of this study were to quantify the levels of Salmonella spp. in the lairage of a large pig abattoir and to compare the effect on environmental contamination levels with Salmonella spp. of the cleaning procedures carried out daily to those undertaken weekly. A total of 359 swabs were collected from lairage pen floors at three timepoints throughout the course of two slaughter days. All samples were analyzed quantitatively. On day 1, Monday, following weekly cleaning and disinfection, 6% of the 179 floor swabs taken were positive for Salmonella spp. On day 2, Thursday, at the end of the slaughter week, when lairage pens were subjected to high-pressure cold water washing between batches of pigs, 44% of the 180 floor swabs taken were positive for Salmonella spp. Quantitative analysis revealed that the median numbers of salmonellae detected following weekly cleaning and disinfection were approximately 1.8 organisms/100 cm(2). The numbers of salmonellae detected on day 2 were approximately 8 organisms/100 cm(2). The most prevalent serotype isolated in this study was S. Typhimurium (42%). Phage types DT12, DT104b, and U302 comprised the majority of phage types identified. These results highlight the need to develop effective intervention measures to control the spread of Salmonella spp. in the preslaughter environment. PMID:17378705

  17. Diagnostic efficiency of abattoir meat inspection service in Ethiopia to detect carcasses infected with Mycobacterium bovis: Implications for public health

    Directory of Open Access Journals (Sweden)

    Bogale Asseged

    2010-08-01

    Full Text Available Abstract Background Bovine Tuberculosis (BTB is a widespread and endemic disease of cattle in Ethiopia posing a significant threat to public health. Regular surveillance by skin test, bacteriology and molecular methods is not feasible due to lack of resource. Thus, routine abattoir (RA inspection will continue to play a key role for national surveillance. We evaluated efficiency of RA inspection for diagnosis of Mycobacterium bovis infection and discussed its public health implications in light of a high risk of human exposure. Methods The study was conducted in five abattoirs: Addis Ababa, Adama, Hawassa, Yabello and Melge-Wondo abattoirs. The efficiency of routine abattoir (RA inspection was validated in comparison to detailed abattoir (DA inspection, followed by culture and microscopy (CM and region of difference (RD deletion analysis. Diagnostic accuracies (with corresponding measures of statistical uncertainty were determined by computing test property statistics (sensitivity and specificity and likelihood estimations using web-based SISA diagnostic statistics software. Post-test probability of detecting TB infected carcasses was estimated using nomograms. Agreement between RA and DA inspections was measured using kappa statistics. The study was conducted and reported in accordance with standards for reporting of diagnostic accuracy (STARD requirements. Both routine and detailed meat inspection protocols were performed on a subpopulation of 3322 cattle selected randomly from among 78,269 cattle slaughtered during the study period. Three hundred thirty seven carcasses identified through detailed meat inspection protocols were subjected to culture and microscopy; of the 337, a subset of 105 specimens for culture and microscopy were subjected to further molecular testing. Results There was a substantial agreement between RA and DA inspections in Addis Ababa (Kappa = 0.7 and Melge-Wondo abattoirs (Kappa = 0.67. In Adama, Hawassa and Yabello

  18. Occurrence and Distribution of bovine tuberculosis (Mycobacterium bovis in Slaughtered cattle in the abattoirs of Bauchi State, Nigeria

    Directory of Open Access Journals (Sweden)

    Adamu Saleh Saidu

    2015-03-01

    Full Text Available Aim: This study was aimed to determine the prevalence of bovine tuberculosis (bTB in slaughtered cattle in Bauchi State, Nigeria. The cause (s of grossly suspected bTB lesions encountered at the abattoirs during post-mortem (PM, as whether due to Mycobacterium bovis alone or together with other acid fast bacilli (AFB. Materials and Methods: A cross-sectional abattoir based study was conducted on 800 cattle slaughtered in the Northern, Central and Southern zonal abattoirs of Bauchi State, Nigeria, from June to August 2013; using PM meat inspection, Ziehl- Neelsen staining (ZN and confirmatory polymerase chain reaction (PCR techniques. Results: The occurrence of bTB lesions from the organs of slaughtered cattle in Bauchi State, showed that the lungs had the highest number of suspected tissues 65 (54.20%, followed by the lymph nodes 28 (23.30% while the heart, liver, spleen, intestines and mammary glands had the other 8.3%, 6.7%, 5.0%, 1.7%, and 0.8%, suspected tissues respectively. By ZN microscopic staining all 100% (2/2 of the intestines were positive for bTB, followed by the heart with 50% (5/10, then the lungs 29.23% (19/65; while the liver, lymph nodes, and spleen had 25%, 21.43% and 16.67% respectively were tested positive for bTB. It was only the mammary gland that tested negative for bTB in all the suspected tissues sampled. By PCR, the intestines had the highest positive bTB with 100% (2/2, followed by the liver with 12.5% (1/8, and then the lungs with 7.8% (5/65. The lymph nodes had 7.14% (2/28 tissues that tested positive for bTB. However, the spleen, heart and mammary gland were all tested negative with 0%; indicating that the false positive for bTB detected by ZN were confirmed by PCR. While based on the location of the abattoirs in the three senatorial zones of Bauchi State, Bauchi zonal abattoir had the highest number of suspected bTB cases 75 (62.50%, followed by Katagum zonal slaughter house with 32 (26.7% and then Misau with 13

  19. Avaliação audiométrica de trabalhadores ocupacionalmente expostos a ruído e cádmio Audiometric evaluation of noise and cadmium occupationally exposed workers

    Directory of Open Access Journals (Sweden)

    Mauricio T. de Abreu

    2002-08-01

    Full Text Available Introdução: O ruído é caracterizado como o fator mais prevalente na origem de doenças ocupacionais. Também é o agente físico nocivo à saúde mais comum nos ambientes de trabalho, causando perda auditiva. Além do ruído, agentes químicos presentes no meio ocupacional, como solventes e metais pesados, são descritos como causadores de alteração auditiva. Objetivo: Avaliar dois grupos de indivíduos expostos à mesma intensidade de ruído industrial, sendo um desses grupos exposto ao cádmio e outro não, e verificar se a exposição aos dois agentes poluentes é mais prejudicial do que a exposição ao ruído isoladamente. Forma de estudo: Clínico prospectivo. Material e Método: Foi realizado estudo audiométrico de 36 trabalhadores de indústria metalúrgica, expostos a ruído e fumos de cádmio em seu ambiente de trabalho, no período de 1994 a 1998. Os resultados obtidos nesse grupo foram comparados aos de um grupo controle composto de 36 trabalhadores dos mesmos setores da empresa, porém expostos somente ao ruído. Resultados: Observou-se uma perda auditiva concentrada principalmente nas freqüências de 4000 e 6000 Hz, mais acentuada no grupo exposto ao ruído e cádmio. Conclusão: Os dados indicaram uma provável ação ototóxica do metal cádmio quando associado à exposição ao ruído.Introduction: Noise is the most common harmful agent present in industrial environments, leading to hearing loss. Besides noise, chemical agents also present in industries, such as solvents and metals lead to hearing loss. Aim: Evaluation of two groups of workers exposed to industrial noise, one of these groups was exposed to cadmium and the other was not, and verify if the concomitant exposition to cadmium and noise is more harmful than the exposition only to noise. Study design: Clinical prospective. Material and Method: It was realized an audiometric research with 36 employees in a metallurgical industry, who were exposed to noise and

  20. Cancer mortality of workers exposed to lead:A retrospective cohort study in a smeltery%上海某冶炼厂铅接触工人肿瘤死亡的回顾性队列研究

    Institute of Scientific and Technical Information of China (English)

    叶细标; 倪为民; 周峰; 王红兵; 匡兴亚; 宋桂香; 张莹; 傅华

    2001-01-01

    目的 了解职业铅接触工人肿瘤死亡情况,探讨职业铅接触与肿瘤的关系。 方法 1985年1月1日前在本厂工作1年以上,且1985年1月1日仍存活的男性工人共6 971名组成全队列,其中3 344名在铅接触车间工作的工人组成的亚队列为接触队列。随访从1985年1月1日至1997年12月31日。以上海市人口的肿瘤死亡率作为标准对照,计算标化死亡比(SMR);以本厂非接触人群作内对照计算相对危险度(RR);估计累计接触剂量并进行剂量-反应关系分析。 结果 全队列6 971人共观察87 576人年,接触队列3 344人共观察41 505人年。全队列中,肺癌的SMR(95%CI)为128.0(101.1~159.7)。1965年后入厂的工人肺癌的SMR为463.7(P<0.01)。有铅接触工作史且工龄超过20年的工人鼻咽癌的SMR=408.0(P<0.01),肺癌的SMR=156.6(P<0.01)。肿瘤总计、恶性肿瘤总计、食管癌、胃癌、肝和胆道癌、肺癌和膀胱癌的RR(95%CI)分别为3.25(2.43~3.89)、3.28(2.54~4.32)、3.57(1.08~10.47)、2.93(1.15~4.87)、4.58(2.03~9.97)、8.58(4.82~15.11)、6.66(2.83~13.01)。将累计接触剂量分为高、中、低3个组,中、高组工人恶性肿瘤RR分别为1.62(P<0.05)和1.70(P<0.05),且有随累计接触剂量增加危险性升高的趋势。中、高组工人的肺癌RR分别为2.55(P<0.05)和2.31(P<0.05)。 结论 工人肿瘤死亡危险性升高可能与铅接触有关,但还需要在控制其他职业有害因素接触和非职业性有害因素接触的情况下作进一步的研究。%Objective To determine the mortality of cancer and relative risk of long-term lead exposure workers and to study the relation between occupational lead exposure and cancer. Methods A cohort study including 6 971 male workers employed for at least one year before Jan 1,1985 and still alive at this time,and a subcohort of 3 344 of them worked at lead-exposed workshop was conducted.The study was followed up

  1. Radioanalysis of tissues from occupationally exposed workers

    International Nuclear Information System (INIS)

    The US Transuranium Registry instituted a program for whole-body donation in 1976 to improve the data on the distribution of transuranics within the entire skeleton and those tissues not available from a routine autopsy. Two whole bodies have been submitted for radiochemical analysis. The first, a 241Am exposure, has been described in an earlier report. The primary exposure of the second donor (a chemist in the Manhattan Project) was to 239Pu in 1945. Of the total whole-body deposition of 6.52 nCi in the second case, 56% remained in the lung and tracheobronchial lymph nodes; 44% (2.86 nCi) was distributed through the systemic system with 46% of this burden in the liver and 46% in the skeleton. 5 references, 2 tables

  2. Detection rate analysis on neurological sign of workers exposed to different concentrations of carbon disulfide%接触不同浓度二硫化碳工人神经系统体征异常检出率分析

    Institute of Scientific and Technical Information of China (English)

    李奎荣; 周文慧; 谷桂珍; 周世义; 郑玉新; 余善法

    2014-01-01

    effects of exposed to different concentrations of carbon disulfide on neurological signs of workers.Methods Collection the information of concentration of carbon disulfide in the workplace or workers individuals exposed of a chemical fiber industry from 2004 to 2011,a total of 3 537 workers exposed to carbon disulfide were detected muscle strength and muscle tone,knee reflex,Achilles tendon reflex,trembling limbs,sensory function,and three chatter.Chi-square test was used for statistical analysis on abnormal neurological signs of workers.Results Eight hours time-weighted average concentration range of workers exposed to carbon disulfide in this chemical fiber industry was 0.2-41.0 mg/m3,geometric mean was 2.38 mg/m3.Concentration of carbon disulfide exposure of 1 771 workers was from 0.2 to 2.5 mg/m3 (≤ 2.5 mg/m3),642 workers was 2.6-4.8 mg/m3 (< 5.0 mg/m3),other 1 051 workers was from 5.1 to 41.0 mg/m3 (> 5.0 mg/m3) in all subjects.The different detection rates of knee reflex were 3.0% (31/1 045),3.7% (21/574),4.8% (16/331),3.3% (10/305),5.9% (11/187),6.7% (68/1 022),the different detection rates of Achilles tendon reflex were 2.2% (23/ 1 045),3.7%(21/574),2.7% (9/331),2.3% (7/305),2.1% (4/187),5.6% (57/1 022),the different detection rates of sensory dysfunction were 0.4% (4/1 045),0.5% (3/574),0.6% (2/331),0.0% (0/305),2.1% (4/187),1.7% (17/1 022) in different cumulative amount of contact groups(≤ 10.0,10.1-20.0,20.1-30.0,30.1-40.0,40.1-50.0,> 50.0 mg/m3 per year),and the differences were statistically significant(x2 =-19.53,21.27 and 15.89,all P values were < 0.01).Stratified according to age and gender,in addition to the ≤25 years group the difference of detection rate analysis on Achilles tendon reflex was statistically significant in the different concentration group(the ratio of on Achilles tendon reflex in the different groups of concentration of carbon disulfide exposure of 2.5,2.6-5.0,≥5.0 mg/m3 were 0.4% (2

  3. Effects of scalding and dehairing of pig carcasses at abattoirs on the visibility of welfare-related lesions.

    Science.gov (United States)

    Carroll, G A; Boyle, L A; Teixeira, D L; van Staaveren, N; Hanlon, A; O'Connell, N E

    2016-03-01

    There is increasing interest in developing abattoir-based measures to assist in determining the welfare status of pigs. The primary aim of this study was to determine the most appropriate place on the slaughter line to conduct assessments of welfare-related lesions, namely apparent aggression-related skin lesions (hereafter referred to as 'skin lesions'), loin bruising and apparent tail biting damage. The study also lent itself to an assessment of the prevalence of these lesions, and the extent to which they were linked with production variables. Finishing pigs processed at two abattoirs on the Island of Ireland (n=1950 in abattoir A, and n=1939 in abattoir B) were used. Data were collected over 6 days in each abattoir in July 2014. Lesion scoring took place at two points on the slaughter line: (1) at exsanguination (slaughter stage 1 (SS1)), and (2) following scalding and dehairing of carcasses (slaughter stage 2 (SS2)). At both points, each carcass was assigned a skin and tail lesion score ranging from 0 (lesion absent) to 3 or 4 (severe lesions), respectively. Loin bruising was recorded as present or absent. Differences in the percentage of pigs with observable lesions of each type were compared between SS1 and SS2 using McNemar/McNemar-Bowker tests. The associations between each lesion type, and both cold carcass weight and condemnations, were examined at batch level using Pearson's correlations. Batch was defined as the group of animals with a particular farm identification code on a given day. The overall percentage of pigs with a visible skin lesion (i.e. score>0) decreased between SS1 and SS2 (Ppigs with a severe skin lesion increased numerically from SS1 to SS2. The percentage of pigs with a visible tail lesion and with loin bruising also increased between SS1 and SS2 (Ppigs with skin lesions, tail lesions and loin bruising (Ptail lesions and loin bruising are more visible on pig carcasses after they have been scalded and dehaired, and that this is when

  4. Asthma characteristics in cleaning workers, workers in other risk jobs and office workers

    NARCIS (Netherlands)

    Zock, JP; Kogevinas, M; Sunyer, J; Jarvis, D; Toren, K; Anto, JM

    2002-01-01

    Several studies have demonstrated an excess risk for asthma among cleaning workers. The aim of this analysis was to compare clinical, immunological and functional characteristics associated with asthma in cleaners and other occupational groups. Cleaners, workers exposed to high molecular weight (MW)

  5. Assessment of livestock slaughtered for food and meat inspection issues in selected abattoirs in Benue State, Nigeria

    OpenAIRE

    Kundu Shima; Idusiye Mosugu; Ternenge Apaa

    2015-01-01

    In recent times, many zoonotic diseases have emerged with serious negative consequences on humans. In the light of this, ante-mortem inspections were conducted, using body condition scoring to assess the health status of livestock presenting for slaughter, and to identify issues relating to meat inspection in four purposively selected government approved abattoirs in Benue State, Nigeria. The result of our assessment showed that 5.0% of the cattle and goats presented for slaughter during the ...

  6. Abattoir-based study on the epidemiology of caprine tuberculosis in Ethiopia using conventional and molecular tools

    OpenAIRE

    Deresa, Benti; Conraths, Franz J.; Ameni, Gobena

    2013-01-01

    Background Despite the important role of goats for meat and milk production in Ethiopia, little information is available on the epidemiology of caprine tuberculosis (TB). Caprine TB is important as milk is usually consumed raw particularly by Ethiopian pastoralists. The objectives of the present study were to estimate the prevalence of TB in goats at an abattoir, to evaluate associated risk factors and to characterize the causative mycobacteria. Methods A cross-sectional study was conducted o...

  7. Losses associated with mortality of cattle and camels during transportation to Oko-Oba abattoir, Lagos State, Nigeria

    Directory of Open Access Journals (Sweden)

    Ademola A. Ibironke

    2010-03-01

    Full Text Available Many food animals meant for slaughter arrive at the Agege abattoir and lairage daily to be produced into wholesome meat for human consumption. These animals generally get to the abattoir packed in Lorries and transported over long distances for many days to get to their destinations. Over a period of 36 months (three years, a total of 1179492 cattle and 11403 camels arrived for slaughter at the abattoir for human consumption. Over the same period, 1197 cattle and 27 camels died in the course of transportation due to the stress and inhumane treatment during transport. All the animals that arrived dead in transit had their carcass totally condemned and destroyed resulting in substantial losses to cattle traders, butchers and the general citizenry. Some of the reasons for these mortalities associated with transportation included overcrowding, long transportation without resting, stress, poor access road networks and traders not adhering to minimal space requirement for animal transportation in a bid to increase their profit margins. Failure to address the issue of proper transportation of food animals are likely to lead to more losses of food animals during transportation.

  8. Assessment of livestock slaughtered for food and meat inspection issues in selected abattoirs in Benue State, Nigeria

    Directory of Open Access Journals (Sweden)

    Kundu Shima

    2015-12-01

    Full Text Available In recent times, many zoonotic diseases have emerged with serious negative consequences on humans. In the light of this, ante-mortem inspections were conducted, using body condition scoring to assess the health status of livestock presenting for slaughter, and to identify issues relating to meat inspection in four purposively selected government approved abattoirs in Benue State, Nigeria. The result of our assessment showed that 5.0% of the cattle and goats presented for slaughter during the investigation period were highly emaciated animals with a prevalence range of 0.0–12.1% with variance between abattoirs, whereas 37.9% were moderately emaciated and 57.2% had good body condition. Extreme emaciation was higher in cattle (6.7% compared to the goats (3.2%. The moderately high prevalence of emaciated animals intended for human consumption coupled with unorganized and inappropriate meat inspection in the studied abattoirs has serious public health implications. To prevent consumers from contacting zoonotic diseases, education of butchers and traders is necessary for thorough and effective inspections. In addition, animal traders should be encouraged to seek veterinary assistance for their sick animals. Meat inspectors should treat all emaciated animals as suspects, as emaciation could be a cause from underlying health problems.

  9. Effect of Low-dose Ionized Radiation on Hemogram and Cytogenetics of Exposed Workers%低剂量电离辐射对放射工作人员血像及细胞遗传学影响

    Institute of Scientific and Technical Information of China (English)

    李全开; 张素英; 胡江

    2011-01-01

    目的 检测与分析职业性接触低剂量电离辐射与受照人群健康指标的关系.方法运用流行病学横断面调查,检测放射场所辐射剂量、个人剂量、血象以及细胞遗传学指标.结果 放射场所不同操作岗位的X射线与r射线剂量率范围为0.0497~3.346 uSv/h,合格率为100%.射线接触组的淋巴细胞计数高于对照组,差异有统计学意义(P<0.01).射线接触组染色体畸变率及阳性检出率分别为0.16%、17.05%,而对照组阳性检出率分别为0.04%、5.1%;接触组微核率及阳性检出率分别为1.03‰、48.06%,而对照组微核率及阳性检出率分别为0.2‰、12.25%,差异均有统计学意义(P<0.01);不同年有效剂量、累积有效剂量组染色体畸变率、微核率与对照组比较,差异有统计学意义(P<0.01);且随着个人年有效剂量、累积有效剂量水平的增高,染色体畸变率、微核率、微核阳性检出率有增高趋势.结论 长期低剂量电离辐射,对淋巴细胞产生的辐射效应导致的淋巴细胞计数增加、染色体畸变率、微核率增加与放射人员个人年剂量、累积剂量密切相关.%Objective To monitor the health effect of low- dose ionized radiation on occupationally exposed workers and to analyze its characteristic of cytogenetics and hemogram. Methods Cross--sectional study was used. The exposure dosages were determined by personal dosimeter, indexes of cytogenetics and hemogram were monitored. Results At different radiation exposure posts, the dose rates of X and γ rays ranged in 0.0497~3. 346 uSv/h, rate of compliance was 100%. The lymphocytes counts of exposed group were significantly higher than those of the control group(P<0.05). The rates of chromosome aberrations and micronuclei of exposed group were significantly higher than those of the control group(P<0. 01). In effective doses of different years and accumulated effective dose group, the rates of chromosome aberrations and

  10. Variable abattoir conditions affect Salmonella enterica prevalence and meat quality in swine and pork.

    Science.gov (United States)

    Hurd, H S; Gailey, J K; McKean, J D; Griffith, R W

    2005-01-01

    Research suggests that abattoir holding pens pose significant Salmonella enterica risk to swine immediately preharvest. The goal of this study was to evaluate those factors related to holding that increased the prevalence of S. enterica in swine at slaughter. To accomplish this goal, we focused on holding time and flooring. Our objectives were to (1) compare Salmonella enterica prevalence among pigs held for short (15-45 min) versus long (up to 4 h) periods before slaughter; and (2) determine the impact of flooring (slatted vs. concrete) as it relates to the prevalence of S. enterica. The study consisted of seven repetitions at a large volume (11,000 head/day) Midwest abattoir. Each repetition consisted of one truck load of pigs (n = 170) sorted into one of three groups: (1) animals held for a short time (15-45 min) on solid floors (short-hold); (2) animals held for 4 +/- 0.5 h on slatted floors; and (3) animals held for 4 +/- 0.5 h on solid concrete floors. At slaughter, samples were collected from 30 pigs in each group. Cecal contents (20 mL), feces (20 g), and the ileocecal lymph node were cultured for S. enterica. Additionally, the effect of holding time on meat quality parameters (loin pH at 35 min and 6 h, color, drip loss) was evaluated for the first four replicates. The proportion of S. enterica-positive samples was highest (p concrete floors (72.4%), and slightly less for pigs held on slatted floors (63.3%). Animals held for less than 45 min before slaughter demonstrated the lowest proportion of S. enterica-positive samples (52.9%). The pig prevalence, as measured by any one of the three samples being positive, was significantly different (p floors (81%) and those animals held for 45 min or less before slaughter (69%). Meat quality, as measured by multiple parameters, was adversely affected by lack of a rest period. The mean 24-h pH was significantly lower for the short-hold group compared to the other two groups. The mean Minolta L and the drip loss were

  11. Worker Participation

    Science.gov (United States)

    Shepherd, W. F.

    1973-01-01

    The philosophy and workability of the concept of worker participation in management decisions is discussed in the context of British society. It is recommended that four interests be represented in any kind of Workers' Council: management, workers, shareholders, and consumers. (AG)

  12. Behavior of the Energy Secretary in working matter: the case of workers exposed to nuclear energy (ionizing radiations); Actuacion de la Secretaria de Energia en materia laboral: el caso de los trabajadores expuestos a energia nuclear (radiaciones ionizantes)

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez J, G

    2006-07-01

    Nuclear Safety and Safeguards, dis concentrated organ of the Secretary of Energy, referring brief antecedents of their creation and emphasizing their mission. The generic and specific attributions are analyzed, as well as the approval abilities and policy-inspection and surveillance, imposition of sanctions and application of safety measures that have been conferred it by law, of where it comes off it performance in the labor circles. In the third chapter there are relative purely technical questions to the nuclear energy and to the occupationally exposed by it use hard-workers. By this way topics such as energy and ionizing radiations are studied, their applications, practices and effects; as well as the importance of the radiological protection and their connection with the safety and hygiene in the work for exposure to physical agents. In the fourth chapter an analysis of the different existent normative instruments is made in the national and international juridical mark, beginning, according to the Kelsen pyramid, with the Political Constitution of the Mexican United States for later to revise the Agreement 115 of the Work International Organization and the Regulation Law of the Article 27 Constitutional in Nuclear Matter and to crumble the General Regulation of Radiological Safety and the applicable Mexican Official Standards whose surveillance runs in charge of the Dis concentrated Regulator Organ that has made an appointment. Finally, it is presented, the case analysis in where the intervention can be appreciated, through the imposition of sanctions, of the referred dependence in the labor relationships of certain work centers. (Author)

  13. Trypanosomiasis in Red Sokoto and West African Dwarf Goats at Ikpa Abattoir, Nsukka, Enugu State, Nigeria

    Directory of Open Access Journals (Sweden)

    Okafor Obioma Juliet

    2013-10-01

    Full Text Available Goat serves as a major investment to most homes in Nigeria, mainly for provision of animal protein and income. The output of this animal is disturbed by Tsetse infestation which is the primary vector of Trypanosome. A survey of Trypanosomiasis of goat in Ikpa abattoir Nsukka, Enugu State, Nigeria was carried out between September and October 2010. This was aimed at determining the species of Trypanosome prevalent in the area and their infection rates among breeds of goat. 106 goats were sampled, among which 15(14.1% were positive for Trypanosome infection. The infection rates among the goat breeds were; Sokoto red (10.4% and West African Dwarf Goat (50.0%. The species of Trypanosome encountered were Trypanosoma vivax(66.7% and Trypanosoma brucei (33.3%. In the infection by sex, this was common among female goats in the various breeds examined and this stood as follows; 9.4% in Sokoto red and 4.7% in West African Dwarf goat. Considering the overall infection rate of Trypanosome in the breeds of goat in the study area, this was relatively high when compared with similar results in related areas; chemo prophylactic and insect control measures should be put in place to rescue the area.

  14. Prevalence of Linguatula serrata Infection in Domestic Bovids Slaughtered in Tabriz Abattoir, Iran

    Directory of Open Access Journals (Sweden)

    G Anaraki-Mohammadi

    2009-07-01

    Full Text Available "nBackground:  Linguatulosis is a rare zoonotic parasitic infection, in which human plays the role of both defini­tive and intermediate host and can be occasionally infected. This study determines the status of infection in live­stock and its po­tential risk to men in the northwestern province of Azarbaijan-e-Sharghi, Iran. "nMethods: In a cross-sectional study from June 2007 to June 2008, 800 slaughtered animals including 400 cattle and 400 buffaloes from Tabriz abattoir in Azarbaijan-e-Sharghi Province were randomly selected and examined for L. serrata nymphs. After primary macroscopical inspection, all liver and lung samples were cut to small pieces, treated with a tissue digestion method and checked macroscopically and micro­scopically for free or encapsulated nymphs. "nResults: Out of 800 animals, 3 (0.38% were found to be infected with L. serrata nymphs and the preva­lence of infection in cattle and buffaloes was determined to be 0.25% and 0.5%, respectively. "nConclusion: Linguatula infection occurs as an endemic zoonosis in the study area and has an active transmission life cycle.

  15. Reproductive health status of north western Himalayan Gaddi sheep: An abattoir study.

    Science.gov (United States)

    Sharma, A; Kumar, P; Singh, M; Vasishta, N K

    2014-01-01

    The study was aimed to provide basic information regarding reproductive status of Gaddi sheep reared by nomadic tribe of Himachal Pradesh. Female genitalia of Gaddi sheep (n=190) were collected from unorganized abattoirs around Palampur over a period of one and half years. Out of total genitalia examined, 80.53% were grossly normal and 19.47% had one or more genital abnormalities. Genital abnormalities were categorized as ovarian (5.26%), uterine (10.53%) and miscellaneous (3.68%). Amongst ovarian abnormalities are follicular cysts (3.16%) and ovaro-bursal adhesions (2.10%), which were recorded in Gaddi ewes. Uterine abnormalities include hydrometra (4.74%), pyometra (2.63%), mucometra (2.10%), endometritis (0.53%) and mummification (0.53%). Miscellaneous abnormalities include parovarian cysts (2.10%), parasitic cysts (1.05%) and nodules on both uterine horns (0.53%). Among the genital abnormalities in sheep, highest incidence (24.32%) was observed with hydrometra and lowest (2.7%) with each of endometritis, mummification and nodular growth on both uterine horns. Thus the uterus (54.07%) was most commonly affected, followed by the ovary (27.02%) and miscellaneous (18.91%) in ewes. In present study, 8.95% pregnant sheep were also slaughtered, with fetal age in majority of cases two months or less on the basis of CRL measurement which represents a huge economic loss. PMID:26623348

  16. Reproductive health status of north western Himalayan Gaddi sheep: An abattoir study

    Directory of Open Access Journals (Sweden)

    A. Sharma

    2014-11-01

    Full Text Available The study was aimed to provide basic information regarding reproductive status of Gaddi sheep reared by nomadic tribe of Himachal Pradesh. Female genitalia of Gaddi sheep (n=190 were collected from unorganized abattoirs around Palampur over a period of one and half years. Out of total genitalia examined, 80.53% were grossly normal and 19.47% had one or more genital abnormalities. Genital abnormalities were categorized as ovarian (5.26%, uterine (10.53% and miscellaneous (3.68%. Amongst ovarian abnormalities are follicular cysts (3.16% and ovaro-bursal adhesions (2.10%, which were recorded in Gaddi ewes. Uterine abnormalities include hydrometra (4.74%, pyometra (2.63%, mucometra (2.10%, endometritis (0.53% and mummification (0.53%. Miscellaneous abnormalities include parovarian cysts (2.10%, parasitic cysts (1.05% and nodules on both uterine horns (0.53%. Among the genital abnormalities in sheep, highest incidence (24.32% was observed with hydrometra and lowest (2.7% with each of endometritis, mummification and nodular growth on both uterine horns. Thus the uterus (54.07% was most commonly affected, followed by the ovary (27.02% and miscellaneous (18.91% in ewes. In present study, 8.95% pregnant sheep were also slaughtered, with fetal age in majority of cases two months or less on the basis of CRL measurement which represents a huge economic loss.

  17. Microbial community structure associated with the high loading anaerobic codigestion of olive mill and abattoir wastewaters.

    Science.gov (United States)

    Gannoun, Hana; Omri, Ilhem; Chouari, Rakia; Khelifi, Eltaief; Keskes, Sajiaa; Godon, Jean-Jacques; Hamdi, Moktar; Sghir, Abdelghani; Bouallagui, Hassib

    2016-02-01

    The effect of increasing the organic loading rates (OLRs) on the performance of the anaerobic codigestion of olive mill (OMW) and abattoir wastewaters (AW) was investigated under mesophilic and thermophilic conditions. The structure of the microbial community was also monitored. Increasing OLR to 9g of chemical oxygen demand (COD) L(-1)d(-1) affected significantly the biogas yield and microbial diversity at 35°C. However, at 55°C digester remained stable until OLR of 12g of CODL(-1)d(-1) with higher COD removal (80%) and biogas yield (0.52Lg(-1) COD removed). Significant differences in the bacterial communities were detected between mesophilic and thermophilic conditions. The dominant phyla detected in the digester at both phases were the Firmicutes, Actinobacteria, Bacteroidetes, Synergistetes and Spirochaete. However, Verrucomicrobia, Proteobacteria and the candidate division BRC1 were only detected at thermophilic conditions. The Methanobacteriales and the Thermoplasmales were found as a high predominant archaeal member in the anaerobic sludge. PMID:26687494

  18. Physicochemical and microbiological assessment of Oko-oba--a Nigerian abattoir.

    Science.gov (United States)

    Adeleye, I A; Adebiyi, A A

    2003-07-01

    The physicochemical and microbiological assessments of Oko-oba abattoir were carried out during dry and wet season to determine whether the waste discharges are within tolerable limits. All the physicochemical parameters studied showed seasonal variations. Higher temperature and lower pH values were recorded during the dry season than wet season. Similarly, the BOD of wastewater from the slab decreases from 10000 mg/ml during the dry season to 6000 mg/ml in the wet season. Conversely, the BOD of the final waste discharge was 4000 mg/ml during the dry season and 3,500 mg/ml during the wet season. The COD showed similar trend, with values ranging from 12,200 to 18,500 mg/ml depending on the season. The suspended solid values ranged from 1200 to 1950 mg/ml. The phosphate and nitrate ions were in the range of 41-75 mg/l and 22.5- 960 mg/ml respectively. Heavy metals detected were Chromium at 104 -114 mg/ml, Copper 16 -75 mg/ml and Iron 55- 114 mg/ml. The following bacteria species were also encountered: B. cereus, E. coli, P. aeruginosa, S. aureus, S. faecalis, S. lactis, Micrococcus sp, A. aerogenes, P. vulgaris, and S. typhi. The results showed significantly high level of pollutants in the waste discharged. PMID:15259608

  19. Suitability and limitations of portion-specific abattoir data as part of an early warning system for emerging diseases of swine in Ontario

    Directory of Open Access Journals (Sweden)

    Thomas-Bachli Andrea L

    2012-01-01

    Full Text Available Abstract Background Abattoir data have the potential to provide information for geospatial disease surveillance applications, but the quality of the data and utility for detecting disease outbreaks is not well understood. The objectives of this study were to 1 identify non-disease factors that may bias these data for disease surveillance and 2 determine if major disease events that took place during the study period would be captured using multi-level modelling and scan statistics. We analyzed data collected at all provincially-inspected abattoirs in Ontario, Canada during 2001-2007. During these years there were outbreaks of porcine circovirus-associated disease (PCVAD, porcine reproductive and respiratory syndrome (PRRS and swine influenza that produced widespread disease within the province. Negative binomial models with random intercepts for abattoir, to account for repeated measurements within abattoirs, were created. The relationships between partial carcass condemnation rates for pneumonia and nephritis with year, season, agricultural region, stock price, and abattoir processing capacity were explored. The utility of the spatial scan statistic for detecting clusters of high partial carcass condemnation rates in space, time, and space-time was investigated. Results Non-disease factors that were found to be associated with lung and kidney condemnation rates included abattoir processing capacity, agricultural region and season. Yearly trends in predicted condemnation rates varied by agricultural region, and temporal patterns were different for both types of condemnations. Some clusters of high condemnation rates of kidneys with nephritis in time and space-time preceded the timeframe during which case clusters were detected using traditional laboratory data. Yearly kidney condemnation rates related to nephritis lesions in eastern Ontario were most consistent with the trends that were expected in relation to the documented disease outbreaks

  20. Cognitive and memory function evaluation on young and middle-aged workers occupationally exposed to aluminum%中青年铝作业工人认知记忆功能评价研究

    Institute of Scientific and Technical Information of China (English)

    任佩; 李瑞; 樊瑾; 原宇宙; 牛侨

    2016-01-01

    目的 分析中青年铝作业工人认知记忆功能的特征性改变情况.方法 采用整群抽样方法,以358名从事铝电解作业1.0年以上的19.0~55.0岁作业工人为研究对象,采用简易精神状态检查量表(MMSE)、画钟试验(CDT)、数字广度测试[DST,包括正序测试(DSFT)与倒序测试(DSBT)]、词语流畅性测验(VFT)、物体记忆测验(FOME)和简单反应时(SRT)测试评价其认知记忆功能;采用石墨炉原子吸收法测定研究对象血铝水平作为内接触指标,根据其中位数(M)和第25、75百分位数(P25,P75)分为低、中和高铝接触组.结果 研究对象血铝水平M(P25,P75)为135.47(87.42,202.24)μg/L.高铝接触组人群DST、DSFT和VFT得分分别低于低、中铝接触组[DST:16(13,19)vs 18(14,21)分,16(13,19)vs 18(15,20)分,P0.05).多元逐步线性回归分析结果显示,血铝水平与VFT得分呈负相关(P0.05).结论 长期职业性铝接触可对中青年作业工人的记忆功能造成损害,主要发生在听觉注意力、听觉记忆广度和言语执行功能方面,并呈现一定的剂量-效应关系.%Objective To analyze the characteristic changes of cognitive and memory function in young and middle-aged workers occupationally exposed to aluminum.Methods By cluster sampling method, 358 workers aged 19.0-55.0 years and engaged in aluminum electrolytic work for more than 1.0 year were selected as research objects.The cognitive and memory function were tested and evaluated by Mini-Mental State Examination ( MMSE ) , Clock-drawing Test ( CDT ) , Digit-span Test [ DST, including Digit-span Forward Test ( DSFT ) and Digit-span Backward Test ( DSBT ) ] , Verbal Fluency Test ( VFT) , Fuld Object Memory Evaluation ( FOME) and Simple Reaction Time ( SRT) .Plasma aluminum was measured using graphite furnace atomic absorption spectrometry and used as internal exposure indicator.The research objects were divided into low-, medium-and high-dose aluminum exposure groups based on the

  1. Trends in the microbial contamination of bovine, ovine and swine carcasses in three small-scale abattoirs in central Italy: A four-year monitoring.

    Science.gov (United States)

    Petruzzelli, Annalisa; Osimani, Andrea; Pasquini, Marina; Clementi, Francesca; Vetrano, Vittorio; Paolini, Francesca; Foglini, Martina; Micci, Eleonora; Paoloni, Alberto; Tonucci, Franco

    2016-01-01

    The microbial contamination of animal carcasses with respect to the limits established by Regulation (EC) No. 2073/2005 was investigated. Bovine, ovine, and swine carcasses (n=536 samples) from three small-scale abattoirs were sampled using abrasive sponges and tested for aerobic colony counts (ACC) and Enterobacteriaceae in the period 2010-2013. Mean ACC values reached 1.96 log cfu/cm(2) on bovine carcasses and 2.27 log cfu/cm(2) on both swine and ovine carcasses; Enterobacteriaceae counts of 0.01, 0.20 and 0.27 log cfu/cm(2) were found for bovine, swine and ovine carcasses, respectively. Abattoir 1 showed the highest values of ACC; no differences among abattoirs were highlighted for Enterobacteriaceae. Compared with swine and ovine carcasses, bovine carcasses showed significantly lower means for both ACC and Enterobacteriaceae. The data collected indicated that the management of the three abattoirs met high quality standards, thereby proving that it is feasible to achieve good microbiological quality in abattoirs when adequate Good Hygiene Practices are applied.

  2. 常熟市小型蓄电池厂148名铅作业工人的血铅与血液锌原卟啉水平调查%Survey of blood lead and blood zinc protoporphyrin in 148 lead exposed workers in small battery factories of Changshu City

    Institute of Scientific and Technical Information of China (English)

    屈振东; 王庆丰

    2013-01-01

    [Objective] To understand the blood lead and blood zinc protoporphyrin levels among zinc exposed workers. [Methods] Venous blood samples were collected from 148 lead exposed workers in 2 small battery factories of Changshu City. Graphite furnace atomic absorption spectrometry was adopted to determine blood lead level, and zinc protoporphyrin instrument for erythrocyte zinc protoporphyrin level. [Results] The blood lead levels of 148 workers were 0.65-3. 61 jxmol/L, 102(68.92% ) were over standard. The erythrocyte zinc protoporphyrin level ranged 0.54-19.7 u,mol/L, 66 (44. 59% ) were over standard. The blood lead was related with erythrocyte zinc protoporphyrin level in male workers not in female workers. [Conclusion] Due to the serious lead pollution in small battery factories, the blood lead and blood zinc protoporphyrin levels exceed standard seriously among zinc exposed workers. The supervision department should urge enterprises to improve production processes and carry out periodic occupational health surveillance.%目的 了解铅作业工人血铅和血液锌原卟啉水平.方法 采集常熟市2家小型蓄电池厂148名铅作业工人静脉血,用石墨原子吸收法测定血铅,用AVIV206D锌原卟啉仪测定红细胞锌原卟啉.结果 148名铅作业工人血铅检测水平为0.65 ~ 3.61 μmol/L,超标者102人,超标率为68.92%;红细胞锌原卟啉检测水平为0.54~ 19.7 μmol/L,超标者66人,超标率为44.59%.铅作业男工人血铅和红细胞锌原卟啉含量有相关性,女工无相关性.结论 该市小型蓄电池厂由于铅污染严重,作业工人血铅和血液锌原卟啉检超标情况严重,监督部门要督促企业改进生产工艺和定期进行职业健康监护.

  3. Heavy metal residues in beef carcasses in Beni-Suef abattoir, Egypt

    Directory of Open Access Journals (Sweden)

    Fathy A. Khalafalla

    2011-09-01

    Full Text Available A total of 300 samples were collected from cattle slaughtered in the Beni-Suef abattoir in Egypt. Samples included muscle, liver and kidney. Animals were randomly selected from the slaughter line. The age of the slaughtered cattle was less than three years (18-30 months. Samples were packed separately in plastic bags, identified and stored at -18°C until analysis which was performed at the Max Rubner Institute in Kulmbach, Germany, for the following heavy metals residues: lead, cadmium, mercury, arsenic, chromium and nickel in beef muscle, liver and kidney samples. The results revealed that the overall mean residual levels of lead were 8.77 µg/kg, 42.70 µg/kg and 109.42 µg/kg fresh weight in muscle, liver and kidney samples, respectively, while the mean residual levels of cadmium were 1.40 µg/kg, 14.16 µg/kg and 62.56 µg/kg fresh weight, respectively, and the mean arsenic residual levels were 5.06 µg/kg, 4.64 µg/kg and 14.92 µg/kg fresh weight, respectively. The mean residual levels of mercury were 3.91 µg/kg, 5.81 µg/kg and 10.14 µg/kg fresh weight, respectively, and the residual levels of chromium were 11.20 µg/kg, 21.85 µg/kg and 25.49 µg/kg fresh weight, respectively. Finally, the mean residual levels of nickel were 21.17 µg/kg, 14.59 µg/kg and 34.95 µg/kg fresh weight, respectively. The mean values of all heavy metals examined were low and did not exceed the permissible limits adopted by different organisations. Most heavy metals accumulated in higher concentrations in the kidney in comparison to the liver and muscle.

  4. [Night workers and plasmatic cortisol].

    Science.gov (United States)

    Palermo, P; Rosati, M V; Ciarrocca, M; Nicassio, P; Piccoli, F; Cerratti, D; Anzani, M F; Tomei, G; Perugi, F; Monti, C; Palitti, T; Tomao, E; Caciari, T; Tomei, F

    2007-01-01

    The aim of the study is to evaluate whether occupational exposure to night work could cause alterations in the levels of plasmatic cortisol. The interest toward this argument arises form several studies in scientific literature referring the presence of an alteration in the synthesis and release of cortisol in workers exposed to night work. We studied a population of workers employed in night security service and monitoring service of alarm systems in different museums compared to a control group not performing shift-work and/or night work. The exposed and control subjects were compared by age, length of service, smoking habit (n. cigarettes per day), habitual consumption of alcoholic drinks (n. glass of wine/beer per day). We evaluated the levels of plasmatic cortisol on 50 workers exposed to night work, all males of whom 30 smokers and 20 non-smokers and on 50 controls of whom 30 smokers and 20 non-smokers.

  5. Modelling the effect of chilling on the occurrence of Salmonella on pig carcasses at study, abattoir and batch levels by meta-analysis.

    Science.gov (United States)

    Gonzales-Barron, Ursula; Cadavez, Vasco; Sheridan, James J; Butler, Francis

    2013-05-15

    The effect of chilling on the occurrence of Salmonella on pig carcasses was investigated at study, abattoir and batch level by meta-analysis. Both the fixed-effects and random-effects model confirmed (ppig carcasses; although the random-effects solution was preferred to account for the significant variability in effect size (ppig carcasses by a mean ratio of ~1.6 (95% CI: 1.0-2.6). Multilevel meta-analysis models investigating study characteristics that could explain the heterogeneity (τ(2)) in the true effect size among primary studies (τ(2)=0.578), among surveyed abattoirs (τ(2)=0.431), and among sampled batches (τ(2)=0.373), revealed that study size (represented by the moderating variables of 'total sample size' and 'number of batches sampled in an abattoir') and 'carcass swabbed area' have a significant impact (pMeta-analysis was not only instrumental to show that small-size studies (i.e., only one batch sampled per abattoir, total number of sampled carcasses per batchmeta-analysis consists of swabbing carcass areas of at least 500 cm(2) from 25 pre-chill and 25 post-chill carcasses from a single production batch, with a minimum of two batches sampled per surveyed abattoir. If the survey were to be conducted in more than one abattoir, the total sample size should not be less than 400. Two methods to test for publication bias, a common problem in meta-analysis, suggested that whilst the presence of unpublished small-size studies is probable, it is not likely that this would significantly bias the overall chilling effect estimated in this study.

  6. Health management of radiation workers

    International Nuclear Information System (INIS)

    People in Japan have expressed great anxiety about possible radiation and radioactivity after the accident at the Fukushima Daiichi Nuclear Power Plant of Tokyo Electric Power Company's (TEPCO), due to the great earthquake and tsunami in eastern Japan on 11 March 2011. A large number of workers were engaged in response and recovery operations, and they were possibly exposed to high doses of radiation as compared to the general population. In the accident at the Chernobyl Nuclear Power Plant in 1986, high doses of radiation to 134 plant staff and emergency personnel resulted in acute radiation syndrome (ARS), which proved fatal for 28 of them. In the Fukushima accident, six workers were exposed to more than 250 mSv of radiation during the initial response phase, but no one showed ARS. It is necessary to continue registration of radiation doses for all workers who were exposed to radiation to facilitate suitable healthcare management in the future. In addition to radiation exposure, a group of workers were also exposed to other health hazards. Frequent occurrence of heat disorders has been a concern for the workers wearing protective clothing with poor ventilation. A comprehensive program to prevent heat illness was implemented by TEPCO under the guidance of the Ministry of Health, Labour, and Welfare. It is important to provide effective systems not only for prevention of radiation exposure but also for general management of other health risks including heat disorders and infection. (author)

  7. Do working environment interventions reach shift workers?

    DEFF Research Database (Denmark)

    Nabe-Nielsen, Kirsten; Jørgensen, Marie Birk; Garde, Anne Helene;

    2016-01-01

    PURPOSE: Shift workers are exposed to more physical and psychosocial stressors in the working environment as compared to day workers. Despite the need for targeted prevention, it is likely that workplace interventions less frequently reach shift workers. The aim was therefore to investigate whether...... to some extent explained the lack of reach of interventions especially among fixed evening workers. CONCLUSIONS: In the light of the evidence of shift workers' stressful working conditions, we suggest that future studies focus on the generalizability of results of the present study and on how to reach...

  8. Health in relation to occupational exposure to pesticides in the Dutch flower bulb culture : Part 3A : neurobehavioral assessment of workers occupationally exposed to pesticides in the bulb growing industry

    NARCIS (Netherlands)

    Emmen, H.H.; Hooisma, J.; Kullig, B.M.; Brouwer, E.J.

    1992-01-01

    The purpose of the present study was to evaluate the possible effects of occupational exposure to pesticides on central nervous system (CNS) function. A variety of neurobehavioral functions were assessed in a group of 129 workers in the bulb growing industry with at least ten years occupational expo

  9. 接触职业噪声的291名劳动者健康检查结果%Results of health examination of 291 workers occupationally exposed to noise

    Institute of Scientific and Technical Information of China (English)

    徐萍; 李绍静; 任合彦; 张杰

    2013-01-01

    目的 探讨噪声对劳动者健康的影响及防护措施效果.方法 对某制造企业接触噪声作业的291名劳动者进行职业健康检查,测定不同岗位噪声强度,对劳动者耳塞使用状况进行问卷调查,对相关结果进行统计分析.结果 7个工作岗位噪声强度> 85dB(A),接触85 dB(A)以上噪声的劳动者听力异常检出率、心电图异常检出率、高血压检出率均高于接触85 dB(A)及以下噪声的劳动者,差异有统计学意义(P<0.05).两组劳动者耳塞使用状况差异无统计学意义(P>0.05).结论 该企业部分劳动者长期接触超标职业噪声,且防护不力,致使听力和心血管系统出现一定损伤,须要加强防护措施.%[Objective] To investigate the effect of noise on workers' health and the effect of protective measures.[Methods] Occupational health examination was performed on 291 workers from a manufacturing enterprise,intensity noise surveillance was conducted on influenced working sites,investigation was made on use of earplug of the related workers,then making a statistic analysis on aforementioned results.[Results] Noise intensity exceed 85 dB(A) in 7 monitoring site,the rates of abnormal heating,abnormal ECG and hypertension of the workers affected by occupational noise over 85 dB (A) were significantly higher than that of the workers affected by occupational noise below 85 dB (A) (P < 0.05).The use of earplug between the 2 groups was not significantly different (P > 0.05).[Conclusion] Some workers in this enterprise suffer certain aural and cardiovascular impairment due to long term occupational noise exposure and poor personal protection,strong measures must be taken to improve the protection for the workers.

  10. Detection of Pathogenic Escherichia coli and Staphylococcus aureus from Cattle and Pigs Slaughtered in Abattoirs in Vhembe District, South Africa

    Directory of Open Access Journals (Sweden)

    Nicoline F. Tanih

    2015-01-01

    Full Text Available Pathogenic food-borne bacteria have been associated with severe morbidity and mortality in humans and animals. This study was aimed at determining the prevalence of Staphylococcus aureus, Salmonella spp., and Escherichia coli present in cattle and pigs slaughtered in selected abattoirs in Vhembe District and at determining the susceptibility of the isolates to antibiotics. A total of 176 swab samples (28 cattle and 16 pigs of the rump, flank, brisket, and neck of the animals were analyzed using standard microbiological methods. E. coli isolates were genotyped to detect pathogenic strains. Of the 176 samples, 104 (67.5% were positive for E. coli and 50 (32.5% for S. aureus. There was no statistically significant difference (P>0.05 in the isolation rate from the different animal parts or abattoirs. Overall, 14/104 (13.46% of the E. coli isolates were pathogenic strains which included enteropathogenic E. coli (EPEC (bfpA 1.9%, enterotoxigenic E. coli (ETEC (LT 3.8%, and enteroaggregative E. coli (EAEC (aaiC 7.6%. E. coli isolates were resistant (100% to vancomycin and bacitracin. S. aureus (100% were resistant to oxacillin and nalidixic acid. The presence of resistant strains of these bacteria in food of animal origin could serve as important vehicles transmitting these bacteria to humans. This finding is of epidemiological significance.

  11. Prevalence of Linguatula Serrata Nymphs in Mesenteric Lymph Nodes of Cattle and Buffaloes Slaughtered in Ahvaz Abattoir, Iran

    Directory of Open Access Journals (Sweden)

    P Haddad Molayan

    2013-06-01

    Full Text Available Background: Linguatula serrata, one of the parasitic zoonoses, inhabits the canine respiratory system (final hosts. The objective of this study was to determine the prevalence rate of L. serrata nymphs in mesenteric lymph nodes (MLNs of cattle and buffaloes (intermediate hosts that were processed in the Ahvaz, Iran abattoir.Methods: During November 2010 to March 2011, 223 animals (119 cattle and 104 buffaloes, in differ­ent sex and three age groups (3 years old were sampled randomly at Ahvaz abattoir. Up to 35 grams of their mesenteric lymph nodes were examined separately for nymphal stages of L. serrata by digesting the samples with acid- pepsin method, collected the nymphs and counted under stereomicroscope.Results: Overall 37(16.6% of 223 animals were infected with L. serrata nymphs in their mesenteric lymph nodes. Prevalence of the infection in cattle and buffaloes were 16.8% and 16.3% respectively. The number of collected nymphs of MLNs was ranged from 1 to 16. No significant differences were seen in the infection rates between males and females (sexes and age groups in the cattle and buffa­loes (P <0.05.Conclusion: Linguatula serrata has an active life cycle in the studied area and a zoonotic potential for transmission between animal and human. Avoiding use of raw MLNs to dogs can help reduce the infection.

  12. Blood Collection from Local Abattoirs for Mass Production of Tsetse Flies to be used in the Sterile Insect Technique

    International Nuclear Information System (INIS)

    The mass production of tsetse flies (Glossina spp.) for the sterile insect technique (SIT) requires a supply of quality blood. For some years already cattle blood has been used as food for laboratory reared flies. The blood is collected from an abattoir using standard procedures. The collection procedures, handling and storage require aseptic conditions to avoid contamination of the blood, which could be fatal to the flies. Fly mortality caused by low quality blood endangers the success of mass rearing. To rear healthy flies with good survival and production the blood should be of good quality - free of contamination and with a packed cell volume (PCV) above 25%. The present work involved the seasonal collection of blood from abattoirs in the United Republic of Tanzania (Tanga, Arusha, Dodoma, Dar-es-salaam). Dodoma was identified as having the best conditions for blood collection. To assess the quality of the blood as a diet for tsetse, blood was screened for the presence of bacteria, and the pathogens were identified. Protocols were developed for blood quality assurance. (author)

  13. 钢铁厂炼钢和轧钢车间接触噪声工人心电图异常的影响因素分析%Factors influencing electrocardiogram results in workers exposed to noise in steel-making and steel-rolling workshops of an iron and steel plant

    Institute of Scientific and Technical Information of China (English)

    李艳红; 余善法; 谷桂珍; 陈国顺; 周文慧; 吴辉; 焦洁

    2016-01-01

    目的 探讨钢铁厂炼钢和轧钢车间噪声作业工人心电图异常的影响因素.方法 于2013年9至12月采用整群抽样方法,对某钢铁厂炼钢和轧钢车间的3 150名噪声作业工人进行问卷调查和健康检查,有效样本2 915例,其中轧钢车间1 606例、炼钢车间1 309例.分析炼钢和轧钢车间的不同特征人群与其心电图的关系.结果 研究对象的总心电图异常率为26.35%,其中炼钢车间工人心电图异常率(32.24%)高于轧钢车间(21.54%),差异有统计学意义(P<0.05);男性心电图异常率(27.59%)高于女性(18.61%),饮酒工人心电图异常率(28.17%)高于不饮酒工人(23.75%),接触高温工人心电图异常率(29.43%)高于不接触高温工人(20.14%),差异均有统计学意义(P<0.05);累积噪声暴露量<90、90~94、95 ~99、100~104和105~113dB (A)·年的心电图异常率分别为21.21%、21.76%、26.50%、27.27%和32.16%,差异有统计学意义(P<0.05).多因素logistic回归分析表明,累积噪声暴露量105~113 dB(A)·年(OR=1.36,95%CI:1.03~1.80)、饮酒(OR=1.20,95%CI:1.01~1.43)、高温(OR=1.60,95%CI:1.32~1.92)是心电图异常的危险因素.结论 累积噪声暴露量较高、饮酒和高温可能增加炼钢和轧钢车间噪声作业工人的心电图异常率.%Objective To investigate the factors influencing the electrocardiogram results in the workers exposed to noise in steel-making and steel rolling workshops of an iron and steel plant.Methods From September to December,2013,cluster sampling was used to select 3 150 workers exposed to noise in the steel-making and steel-rolling workshops of an iron and steel plant,and a questionnaire survey and physical examinations were performed.The number of valid workers was 2 915,consisting of 1 606 workers in the steel-rolling workshop and 1 309 in the steel-making workshop.The electrocardiogram results of the workers in steel-making and steel

  14. Continuing study of mortality in Hanford workers

    International Nuclear Information System (INIS)

    The mortality of workers at the Hanford Plant in southeastern Washington who have been exposed to penetrating external ionizing radiation is studied. Deaths are analyzed statistically and compared to standardized mortality ratios. Cancer deaths in particular are examined

  15. Pulmonary function in automobile repair workers

    OpenAIRE

    Chattopadhyay O

    2007-01-01

    Background : Automobile repair shop is a place where workers are exposed to harmful chemicals and toxic substances. Objective : To study the occurrence of obstructive and restrictive pulmonary impairment among automobile garage workers. Methods : A cross sectional study involving 151 automobile garage workers from 14 randomly selected garages of urban Kolkata. The study variables were Forced Expiratory Volume in 1 second (FEV 1 ), Forced Vital Capacity (FVC), Peak Expiratory Flow Rate (...

  16. Cohort mortality study of vinyl chloride exposed workers in Porto Marghera during production, polymerization and bagging; Indagine epidemiologica sui lavoratori di Porto Marghera esposti a cloruro di vinile nelle fasi di produzione, polimerizzazione e insacco

    Energy Technology Data Exchange (ETDEWEB)

    Pirastu, R. [Rome, Univ. (Italy). Dipt di Biologia Umana e Animale; Chellini, E. [Centro per lo Studio e la Prevenzione Oncologica, Florence (Italy); Carnevale, F. [Unita` Sanitaria Locale 10, Florence (Italy). Servizio di Prevenzione, Igiene e Sicurezza nei Luoghi di Lavoro; De Santis, M.; Comba, P. [Istituto Superiore di Sanita`, Rome (Italy). Lab. di Igiene Ambientale; Bracci, C. [CGIL Lazio, Rome (Italy). Sindacato Pensionati Italiani

    1997-09-01

    The aim of the study is to investigate cause specific mortality among workers employed in vinyl chloride manufacture, polymerization and bagging in Porto Marghera between start of operation and June 30, 1995. The cohort includes 1.658 subjects employed by the companies running the petrochemical plant in Porto Marghera (Montedison and Enichem) and 272 members of three cooperatives of baggers who operated in the plant. The study detected an increased mortality from liver cancer, especially among autoclave workers, and an increase in lung cancer among baggers. In the whole study period, in the Montedison-Enichem cohort, 11 deaths from liver cancer were observed versus 5.7 expected; among autoclave workers 6 deaths were observed versus 0.8 expected. Four further cases were detected by `Best Evidence` procedures. Altogether 5 cases were angiosarcomas, 5 hepato-carcinomas, 3 cases of liver cancer occurred in cirrhotic subjects and in 2 cases histology was not known. The increase in lung cancer risk among baggers is present both in the Montedison-Enichem cohort and among the members of the cooperatives. The results of the present study will soon be supplemented with those concerning the cohorts in the plants located in Ferrara, Ravenna, Rosignano, Terni and Brindisi.

  17. Detection of Pathogenic Escherichia coli in Samples Collected at an Abattoir in Zaria, Nigeria and at Different Points in the Surrounding Environment

    Directory of Open Access Journals (Sweden)

    Lawan Mohammed Kabiru

    2015-01-01

    Full Text Available Pathogenic Escherichia coli can be released with the wastes coming from slaughterhouses into the environment, where they can persist. We investigated the presence of diarrheagenic E. coli in specimens taken at an abattoir located in the Zaria region, Nigeria, in samples of water from the river Koreye, where the effluent from the abattoir spills in, and vegetable specimens taken at a nearby farm. All the isolated E. coli were assayed for the production of Shiga toxins (Stx by using the Ridascreen verotoxin Immunoassay and by PCR amplification of genes associated with the diarrheagenic E. coli. Three strains from the rectal content of two slaughtered animals and a cabbage were positive for the presence of the Stx-coding genes. Additionally we have isolated one Enteroaggregative E. coli (EAggEC from the abattoir effluent and two Subtilase-producing E. coli from the slaughterhouse’s effluent and a sample of carrots. Our results provide evidence that pathogenic E. coli can contaminate the environment as a result of the discharge into the environment of untreated abattoir effluent, representing a reservoir for STEC and other diarrheagenic E. coli favouring their spread to crops.

  18. Assessing the Effectiveness of On‐Farm and Abattoir Interventions in Reducing Pig Meat–Borne Salmonellosis within E.U. Member States

    DEFF Research Database (Denmark)

    Hill, Andrew A.; Simons, Robin L.; Swart, Arno N.;

    2016-01-01

    effective way to reduce human exposure to Salmonella spp. However, a combined farm/abattoir approach would likely have cumulative benefits. On‐farm intervention is probably most effective at the breeding‐herd level for high‐prevalence Member States; once infection in the breeding herd has been reduced to a...

  19. A systematic review of animal based indicators of sheep welfare on farm, at market and during transport, and qualitative appraisal of their validity and feasibility for use in UK abattoirs.

    Science.gov (United States)

    Llonch, P; King, E M; Clarke, K A; Downes, J M; Green, L E

    2015-12-01

    In the UK, it has been suggested that abattoirs are ideal locations to assess the welfare of sheep as most are slaughtered at abattoirs either as finished lambs or cull ewes. Data from abattoirs could provide benchmarks for welfare indicators at a national level, as well as demonstrating how these change over time. Additionally, feedback could be provided to farmers and regulatory authorities to help improve welfare and identify high or low standards for quality assurance or risk-based inspections. A systematic review of the scientific literature was conducted, which identified 48 animal-based indicators of sheep welfare that were categorised by the Five Freedoms. Their validity as measures of welfare and feasibility for use in abattoirs were evaluated as potential measures of prior sheep welfare on the farm of origin, at market, or during transportation to the abattoir. A total of 19 indicators were considered valid, of which nine were considered theoretically feasible for assessing sheep welfare at abattoirs; these were body cleanliness, carcass bruising, diarrhoea, skin lesions, skin irritation, castration, ear notching, tail docking and animals recorded as 'obviously sick'. Further investigation of these indicators is required to test their reliability and repeatability in abattoirs. Novel welfare indicators are needed to assess short-term hunger and thirst, prior normal behaviour and long-term fear and distress. PMID:26598787

  20. A systematic review of animal based indicators of sheep welfare on farm, at market and during transport, and qualitative appraisal of their validity and feasibility for use in UK abattoirs.

    Science.gov (United States)

    Llonch, P; King, E M; Clarke, K A; Downes, J M; Green, L E

    2015-12-01

    In the UK, it has been suggested that abattoirs are ideal locations to assess the welfare of sheep as most are slaughtered at abattoirs either as finished lambs or cull ewes. Data from abattoirs could provide benchmarks for welfare indicators at a national level, as well as demonstrating how these change over time. Additionally, feedback could be provided to farmers and regulatory authorities to help improve welfare and identify high or low standards for quality assurance or risk-based inspections. A systematic review of the scientific literature was conducted, which identified 48 animal-based indicators of sheep welfare that were categorised by the Five Freedoms. Their validity as measures of welfare and feasibility for use in abattoirs were evaluated as potential measures of prior sheep welfare on the farm of origin, at market, or during transportation to the abattoir. A total of 19 indicators were considered valid, of which nine were considered theoretically feasible for assessing sheep welfare at abattoirs; these were body cleanliness, carcass bruising, diarrhoea, skin lesions, skin irritation, castration, ear notching, tail docking and animals recorded as 'obviously sick'. Further investigation of these indicators is required to test their reliability and repeatability in abattoirs. Novel welfare indicators are needed to assess short-term hunger and thirst, prior normal behaviour and long-term fear and distress.

  1. Assessment of Cold Stress and Its Effects on Workers in a Cold-Storage Warehouse

    OpenAIRE

    Farhang Akbar-Khanzadeh; Mohammad–Hossein Sajadi; Keramat Nouri Jelyani; Farideh Golbabaei

    2009-01-01

    Exposure to cold work environment is an occupational health hazard and poses adverse effect on workers health, performance and productivity. This study was performed in a cold food-storage warehouse complex in Tehran-Iran in order to evaluate the workers' exposure to cold stress. Twenty nine exposed workers and 33 non-exposed workers as control subject were included in this study. Climatic factors were measured based on ISO 7996 at the three levels of workers height. Physiological factor...

  2. Evaluation of the national health surveillance program of workers previously exposed to asbestos in Spain (2008 Evaluación del programa integral de vigilancia de la salud de los trabajadores que han estado expuestos a amianto en España (2008

    Directory of Open Access Journals (Sweden)

    Montserrat García Gómez

    2012-02-01

    Full Text Available Objectives: Although asbestos was banned in Spain in 2001, monitoring the health of previously-exposed workers is required. In 2002 the Ministry of Health and the autonomous regions of Spain planned a health surveillance program for workers exposed to asbestos (Programa de Vigilancia de la Salud de los Trabajadores Expuestos al Amianto [PIVISTEA] with employers' organizations, trade unions and scientific societies. The aim of this study was to evaluate the PIVISTEA to improve its effectiveness. Methods: A questionnaire with indicators for the year 2008 was sent to Spain's 17 autonomous regions, as well as to the autonomous cities of Ceuta and Melilla. The results were analyzed by evaluating the compliance of each program with the activities established by the PIVISTEA. Results: In December 2008, a total of 22,158 workers from 14 autonomous regions and 306 companies were included in the program. The program had been started in 88% of the regions but surveillance activities remained scarce in 24%. Fifty-seven percent of the autonomous regions (69% of the total number of workers provided the information requested. Seven autonomous regions provided data on the relationship between the diseases found and asbestos exposure. Only 5% of these diseases entitled affected individuals to receive compensation for occupational diseases. Conclusions: The health surveillance of workers previously exposed to asbestos in Spain, as well as medical-legal recognition of diseases caused by exposure at work, remain in adequate. Although the trend is positive, the effectiveness of many regional programs is limited, and inter-regional inequalities among affected workers have been detected.Objetivos: Después de la prohibición del amianto en España en 2001, resulta necesario vigilar la salud de los trabajadores expuestos en el pasado. En 2002, el Ministerio de Sanidad y las Comunidades Autónomas consensuaron un Programa de Vigilancia de la Salud de los Trabajadores

  3. Socio-economic implications of bovine liver rejection in a major abattoir in south-western Nigeria

    Directory of Open Access Journals (Sweden)

    Ademola Adeshupo Ibironke

    2010-12-01

    Full Text Available This study considered the common causes of liver rejection in an abattoir in Nigeria. It was estimated and compared mathematically the lead causes of rejection of bovine liver. Fascioliasis was the main cause of liver condemnation and its social and economic implications were studied. A total of Nigerian Naira 15,772,200 [US$134,000] was lost directly due to this disease condition in a three-year period and in a single abattoir. Finally, advice was proffered to minimize the problems associated with liver rejection in Nigeria and to improve public health and animal welfare.Este estudo avaliou as causas mais comuns de rejeição do fígado num matadouro na Nigéria. Foram estimadas e comparadas matematicamente as causa principais de rejeição de fígado de bovinos. A fasciolíase foi a causa principal da reprovação do fígado e foram estudadas as suas implicações sociais e económicas. Apurou-se ter sido perdido um total de 15,772,200 nairas nigerianas (US$ 134,000 directamente devido a esta doença, num período de três anos, num único matadouro. Finalmente, foram definidos e aconselhados procedimentos para minimizar os problemas associados à rejeição de fígado na Nigéria e para melhorar a saúde pública e o bem-estar dos animais.

  4. Polychlorinated biphenyl exposure and effects in transformer repair workers.

    OpenAIRE

    Emmett, E A

    1985-01-01

    Fifty-five present and past transformer repair workers exposed to polychlorinated biphenyls (PCBs) and 56 unexposed comparison workers were evaluated in a clinical-epidemiologic study. The groups were similar in most demographic variables. Adipose tissue lipid and serum PCBs concentrations were higher in current exposed workers (geometric means adipose 2.1 ppm, serum 12.2 ppb). Concentrations in comparison (0.6 ppm and 4.6 ppb) and previously exposed (0.83 ppm and 5.9 ppb) workers were lower....

  5. Older workers

    NARCIS (Netherlands)

    Ybema,J.F.; Giesen, F.

    2014-01-01

    Due to an ageing population and global economic competition, there is a societal need for people to extend their working lives while maintaining high work productivity. This article presents an overview of the labour participation, job performance, and job characteristics of older workers in the Eur

  6. About the contribution of occupational health's services for risk factors evaluation, medical and dosimetric follow-up in the workers monitoring exposed to ionising radiations in France

    Energy Technology Data Exchange (ETDEWEB)

    Bailloeuil, C.; Gonin, M.; Gerondal, M. [Gaz de France (EDF/GDF), 75 - Paris (France)

    2006-07-01

    Full text of publication follows: French national regulation (31/03/2003) indicates principles of a global approach about the medical and dosimetric follow-up in the workers monitoring. Legislator insists on risks and expositions trace ability along all professional career and after. The aim of this French specific system is to institute medical clinic aspects in accordance with dosimetry and professional risks. The occupational practitioners are approved practitioners who have followed a specific training. The organisation guarantees that a worker will be followed by one specific practitioner in order to reinforce the quality and the traceability of follow up. Medical supervision is done at taking on and at least once a year. It means to identify and take care of risks and expositions at work stations. If necessary, biological measurements and recommendations about collective and individual protection equipments complete the estimation of risks. On the subject of emergency, first aid is delivered on sites by occupational health personnel, either for classic medical problem or for radiological accident. Furthermore, occupational health personnel assist outside emergency services with whom we have specific conventions. External dosimetric follow-up is done with radiation protection qualified expert of the company. The internal contamination supervision and internal dose evaluation are done by the occupational health services. Measurements either whole body counts or radio-toxicologic analysis are submitted to technical quality process. Beyond the respect of regulatory dose limits, the aim of the dosimetric follow-up is the contribution to the preparation of work places with strong dosimetric focus. Informations at workers are dispensed about every risks and every kinds of risks: ionising radiation health effects, ionising radiation and pregnancy, high exposition, chemical risks, work at heat, asbestos. All data are conserved 50 years after the exposure These data

  7. Pulmonary function in automobile repair workers

    Directory of Open Access Journals (Sweden)

    Chattopadhyay O

    2007-01-01

    Full Text Available Background : Automobile repair shop is a place where workers are exposed to harmful chemicals and toxic substances. Objective : To study the occurrence of obstructive and restrictive pulmonary impairment among automobile garage workers. Methods : A cross sectional study involving 151 automobile garage workers from 14 randomly selected garages of urban Kolkata. The study variables were Forced Expiratory Volume in 1 second (FEV 1 , Forced Vital Capacity (FVC, Peak Expiratory Flow Rate (PE FR, age, smoking habit, duration of work, type of work, and respiratory symptoms. The study was analysed using Regression equations, and Chi-square test. Results : All the workers were male. Obstructive impairment was seen in 25.83% of the workers whereas restrictive impairment was seen in 21.19% of the workers. Mixed obstructive and restrictive impairment was seen in 10.6% of the workers. The frequency of obstructive impairment was higher in older workers. In the age group of less than 20 years, 13.6% of the workers had obstructive impairment while 42.86% of workers above 40 years of age had obstructive impairment. Obstructive impairment was more frequently observed in battery repair workers (58.33% and spray painters (37.5% while 16.67% of the body repair workers and 30.19% of the engine mechanics had obstructive impairment. Obstructive impairment was more frequently observed in smokers (53.1 % as compared to ex-smokers (33.3% and non-smokers (6.4%. Obstructive impairment was more frequently observed in workers who had been working for a longer duration. Conclusion: Nearly 36.4% of the automobile garage workers had some form of pulmonary function impairment; obstructive and/or restrictive. The use of personal protective equipment, worker education, and discontinuation of the use of paints containing toxic pigments are recommended.

  8. Cytogenetic monitoring, radiosensitivity study and adaptive response of workers exposed to low level ionizing radiation; Monitorizacao citogenetica, estudo de radiossensibilidade e resposta adaptativa em profissionais expostos a baixos niveis de radiacao ionizante

    Energy Technology Data Exchange (ETDEWEB)

    Peitl Junior, Paulo

    1996-07-01

    The objectives of the present study were: To determine the frequencies of chromosome aberrations in lymphocytes from individuals belonging to professionally exposed groups, under normal conditions; to determine the possible differences in radiosensitivity between the lymphocytes of technicians and controls after in vitro irradiation with gamma rays during the G{sub 1} phase of the cell cycle (radiosensitivity study), and to examine the influence of in vivo and in vitro pre-exposure to low doses of radiation on the frequency of chromosome aberrations induced in vitro by high doses (study of the adaptive response) in a group of technicians (T) compared to controls (C). (author)

  9. XRCC3基因多态性与铅作业男工铅毒性易感性的关联研究%Relationship between XRCC3 gene polymorphism and susceptibility to lead poisoning in male lead-exposed workers

    Institute of Scientific and Technical Information of China (English)

    刘祥铨; 张忠

    2013-01-01

    Objective To investigate the relationship between genetic polymorphism of X-ray repair cross-complementing gene 3 (XRCC3) and susceptibility to lead poisoning in male lead-exposed workers.Methods Peripheral venous blood and morning urine samples were collected from 326 male lead-exposed workers in a storage battery factory in Fuzhou.Blood lead,urine lead,blood zinc protoporphyrin (ZPP),blood calcium,and blood iron were measured.The genotype of XRCC3 was determined by polymerase chain reactionrestriction fragment length polymorphism method.The relationship between XRCC3 gene polymorphism and susceptibility to lead poisoning in male lead-exposed workers was analyzed.Results Genetic polymorphism of XRCC3 was seen in the 326 subjects.The frequency distribution of XRCC3 genotypes,XRCC3-241CC (wild type),XRCC3-241CT (heterozygous mutation),and XRCC3-241TT (homozygous mutation),was in accordance with the Hardy-Weinberg equilibrium (P>0.05).There were no significant differences in urine lead,blood ZPP,blood calcium,and blood iron between the lead-exposed workers with different XRCC3 genotypes (P>0.05).The workers with XRCC3-241CT/TT had a significantly higher mean blood lead level than those with XRCC3-241CC (P<0.05).With a blood lead level of 1.90 μmol/L as the cutoff value,the chi-square test and logistic regression analysis showed that the proportion of workers with XRCC3-241CT/TT was significantly higher than that of workers with XRCC3-241CC in the subjects with high blood leads (P<0.05) and that the risk of high blood lead was significantly higher in the workers with XRCC3-241CT/TT than in those with XRCC3-241CC (OR =2.34,95% CI =1.61~5.13); the multivariate linear regression analysis showed that the workers with XRCC3-241CT/TT had high blood lead levels (β=0.116,P<0.05),the workers with smoking habit demonstrated marked lead absorption (β=0.188,P<0.05),good individual protection could reduce lead absorption (β=-0.247,P<0.05),and the individuals

  10. Older workers

    OpenAIRE

    Ybema, J.F.; Giesen, F.

    2014-01-01

    Due to an ageing population and global economic competition, there is a societal need for people to extend their working lives while maintaining high work productivity. This article presents an overview of the labour participation, job performance, and job characteristics of older workers in the European Union. The way in which several factors, including health, working conditions, skills and knowledge, and social and financial factors influence sustainable employability and the early retirem...

  11. Psychomotor Effects of Mixed Organic Solvents on Rubber Workers

    Directory of Open Access Journals (Sweden)

    O Aminian

    2014-04-01

    Full Text Available Background: Exposure to organic solvents is common among workers.Objective: To assess neurobehavioral effects of long-term exposure to organic solvents among rubber workers in Tehran, Iran.Methods: Across-sectional study was conducted on 223 employees of a rubber industry. The participants completed a data collection sheet on their occupational and medical history, and demographic characteristics including age, work experience, education level; they performed 6 psychiatric tests on the neurobehavioral core test battery (NCTB that measure simple reaction time, short-term memory (digit span, Benton, eye-hand coordination (Purdue pegboard, pursuit aiming, and perceptual speed (digit symbol.Results: Workers exposed and not exposed to organic solvents had similar age and education distribution. The mean work experience of the exposed and non-exposed workers was 5.9 and 4.4 years, respectively. The exposed workers had a lower performance compared to non-exposed workers in all psychomotor tests. After controlling for the confounders by logistic regression analysis, it was found that exposure to organic solvents had a significant effect on the results of digit symbols, digit span, Benton, aiming, and simple reaction time tests. No significant effect was observed in pegboard test.Conclusion: Occupational exposure to organic solvent can induce subtle neurobehavioral changes among workers exposed to organic solvents; therefore, periodical evaluation of the central nervous system by objective psychomotor tests is recommended among those who are chronically exposed to organic solvents.

  12. Diversity of Mannheimia haemolytica and pasteurella trehalosi serotypes from apparently healthy sheep and abattoir specimens in the highlands of Wollo, North East Ethiopia.

    Science.gov (United States)

    Sisay, T; Zerihun, A

    2003-01-01

    The prevalence and serotypic diversity of Mannheimia [Pasteurella] haemolytica and Pasteurella trehalosi from nasal swabs, sera and abattoir specimens from sheep in the highlands of Wollo, North East Ethiopia was investigated. Prevalence rates of 83% and 75% of these microorganisms were found in the serum samples and nasal swabs, respectively, from apparently healthy sheep. In a local abattoir, 205 lungs were investigated, 34% of which showed pneumonia, from which samples were collected from 51 lungs and the same number of corresponding tonsils. Mannheimia and Pasteurella species were isolated from 59% of these pneumonic lungs and 69% of the respective tonsils. M. haemolytica serotypes accounted for 41 (59%) and P. trehalosi for 11 (32%) of the isolates from the abattoir specimens. The majority (67%) of isolates from nasal swabs were P. trehalosi, M. haemolytica being isolated f rom 4 (13%) of the swabs. M. glucosida was isolated only from the tonsils. The predominant serotypes of the isolates from both the nasal swabs and the abattoir specimens were M. haemolytica A1 (17%) and P. trehalosi T4 (16%) and T3 (13%). P. trehalosi T15 was less commonly encountered, while M. haemolytica A9 and A13 were not isolated. Studies on sera from 100 sheep indicated that antibodies against M. haemolytica serotype A1 (14%) were most common, followed by A5 and A8 (each 10%) and A9 and P. trehalosi T3 (each 9%) and T4 (8%). Antibodies against M. glucosida or serotype All occurred in 2% of the sera. Multiple serotypes were common in all types of samples. The importance of including in vaccines the most prevalent serotypes involved in the pneumonia of sheep in the area is discussed. PMID:12625399

  13. Influence of Municipal Abattoir Conditions and Animal-related Factors on Avoidance-related Behaviour, Bleeding Times at Slaughter and the Quality of Lamb Meat

    OpenAIRE

    Njisane, Yonela Z.; Muchenje, Voster

    2013-01-01

    The objective of this study was to determine the effect of municipal abattoir conditions and animal factors on avoidance-related behaviour (AB) of sheep at slaughter, bleeding times (BT) and mutton quality. The behaviour of 66 castrates and 19 ewes of different age categories was observed at three stages of slaughter. Higher behaviour scores indicated higher levels of AB. Time intervals between the start of blood flow and the time the flow changed from a constant stream into drips were record...

  14. Medical Surveillance for Former Workers

    Energy Technology Data Exchange (ETDEWEB)

    Tim Takaro

    2009-05-29

    The Former Hanford Worker Medical Monitoring Program, directed by the Occupational and Environmental Medicine Program at the University of Washington, served former production and other non-construction workers who were potentially exposed to workplace hazards while working for the USDOE or its contractors at Hanford. The USDOE Former Workers Program arose from Congressional action in the Defense Authorization of 1993 (Public Law 102). Section 3162 stated that, “The Secretary shall establish and carry out a program for the identification and ongoing medical evaluation of current and former Department of Energy employees who are subject to significant health risks as a result of exposure of such employees to hazardous or radioactive substances during such employment.” (This also covers former employees of USDOE contractors and subcontractors.) The key objective has been to provide these former workers with medical evaluations in order to determine whether workers have experienced significant risk due to workplace exposure to hazards. Exposures to asbestos, beryllium, and noise can produce specific medical conditions: asbestosis, berylliosis, and noise-induced hearing loss (NIHL). Each of these conditions can be identified by specific, non-invasive screening tests, which are widely available. Treatments are also available for individuals affected by these conditions. This project involved two phases. Phase I involved a needs and risk assessment, characterizing the nature and extent of workplace health hazards which may have increased the risk for long-term health effects. We categorized jobs and tasks by likelihood of exposures to specific workplace health hazards; and located and established contact with former Hanford workers. Phase II involved implementation of medical monitoring programs for former workers whose individual work history indicated significant risk for adverse health effects. We identified 118,000 former workers, employed from 1943 to 1997

  15. Relationship between Neurobehavioral Changes in Mn Exposed Workers and Exon 4 Polymorphism in Parkin Gene%锰接触工人神经行为改变与Parkin基因4号外显子多态性的关系

    Institute of Scientific and Technical Information of China (English)

    贾飞飞; 姜慧; 申旭波; 熊云刚; 邹焰

    2011-01-01

    目的 探讨锰接触工人神经行为改变与Parkin基因4号外显子S/N167多态性的相关性.方法 选工龄在半年以上的职业性锰暴露工人200名和劳动强度相似,但工作环境不接触锰工人94名,按累积暴露指数将其分为高、低暴露组和对照组.利用沟槽稳定试验和拼板试验进行神经行为改变检测;利用PCR-RFLP法对Parkin基因4号外显子多态性位点进行基因分型.结果 高暴露组中,Parkin基因4号外显子AA型工人的划痕长度、集合试验得分均低于GG基因型和GA基因型,而碰撞次数高于GG基因型和GA基因型,其差异有统计学意义(P<0.05);低暴露组中,Parkin基因4号外显子AA基因型工人的划痕长度、集合试验得分均低于GG基因型和GA基因型,其差异有统计学意义(P<0.05),3个基因型工人碰撞次数间差异无统计学意义(P>0.05);对照组中,Parkin基因4号外显子3个基因型划痕长度、碰撞次数、集合试验得分之间差异无统计学意义(P>0.05).结论 环境因素和遗传因素共同作用更易导致锰引起神经行为改变;携带Parkin基因4号外显子AA基因型的工人是锰损伤的易感者;Parkin基因4号外显子G601A突变导致的Ser167Asn多态性有可能作为检测锰致神经行为改变以及锰中毒风险评估的指标.%Objective To study the relationship between neurobehavioral changes and Parkin gene polymorphism in manganese exposed workers. Methods 200 Mn exposed workers having working age≥0.5 year and 94 Mn unexposed workers were chosen and divided into high and low exposed groups and control group according to cumulated exposure index(CEI). Every worker was detected by neurobehavioral detective equipment. The genetic DNA was extracted from every worker; the genotypes of exon 4 polymorphism were detected by PCR-RFIP. Results In high exposed group, the subjects with AA genotype were significantly lower in the length of drawing and the scores of Pegboard test

  16. Multivariate regression analysis on influencing factors related to arsenic content in urine of arsine exposed workers%砷化氢作业工人尿中砷含量相关因素的多元线性回归分析

    Institute of Scientific and Technical Information of China (English)

    韦光毅; 柳元; 胡天桥; 陈启玲

    2012-01-01

    目的 分析寻找砷化氢作业工人的尿中砷含量的主要影响因素,为预防砷化氢中毒提供参考.方法 收集132例砷化氢作业工人的尿砷水平及其相关因素的详细资料,采用多元逐步回归和多元线性回归的方法进行统计分析.结果 获得回归方程lgY=0.551 D1+0.281 D2 +0.665X7+0.059X8+0.005 X3 -2.279,决定系数调整R2=0.885,其中D1,D2代表工种的2个虚拟变量,X7代表砷化氢浓度,X8代表自觉症状,X3代表年龄,标准化偏回归系数分别为0.569,0.268,0.624,0.056,0.054.结论 回归方程表明砷化氢作业工人尿砷的主要影响因素为工种、砷化氢浓度,提示预防砷化氢中毒要做好高危工种工人的防护,控制好作业场所空气中砷化氢的浓度.%[ Objective ] To analyze the major factors affecting arsenic levels in urine of workers exposed to arsine, and provide reference for arsine poisoning prevention. [ Methods] Detailed information on arsenic levels in urine and its related factors of 132 cases of workers exposed to arsine was collected. Stepwise multiple regression and multiple linear regression method were used for statistical analysis. [Results] Regression equation was obtained, lg Y = 0. 551 D1 +0. 281 D2 +0. 665 X, + 0. 059 X2 +0. 005 X3-2. 279, adjusted R2 =0. 885, D, , D2 were the two dummy variables of jobs, X7 was the concentration of arsine, X8 was symptoms, X3 was the age. Their standardized partial regression coefficients were 0. 569, 0. 268, 0. 624, 0. 056 and 0. 054. [ Conclusion] The regression equation suggests the main factors affecting arsenic levels in urine of workers exposed to arsine were the types of work and the concentration of arsine, the protection of high-risk workers and the control of air arsine concentration in workplaces should be strengthened.

  17. Medical supervision of radiation workers

    International Nuclear Information System (INIS)

    The first part of this volume describes the effects of radiation on living organism, both at the overall and at the molecular level. Special attention is paid to the metabolism and toxicity of radioactivity substances. The second part deals with radiological exposure, natural, medical and occupational. The third part provides data on radiological protection standards, and the fourth part addresses the health supervision of workers exposed to ionizing radiation, covering both physical and medical control.

  18. Window contamination on Expose-R

    Science.gov (United States)

    Demets, R.; Bertrand, M.; Bolkhovitinov, A.; Bryson, K.; Colas, C.; Cottin, H.; Dettmann, J.; Ehrenfreund, P.; Elsaesser, A.; Jaramillo, E.; Lebert, M.; van Papendrecht, G.; Pereira, C.; Rohr, T.; Saiagh, K.

    2015-01-01

    Expose is a multi-user instrument for astrobiological and astrochemical experiments in space. Installed at the outer surface of the International Space Station, it enables investigators to study the impact of the open space environment on biological and biochemical test samples. Two Expose missions have been completed so far, designated as Expose-E (Rabbow et al. 2012) and Expose-R (Rabbow et al. this issue). One of the space-unique environmental factors offered by Expose is full-spectrum, ultraviolet (UV)-rich electromagnetic radiation from the Sun. This paper describes and analyses how on Expose-R, access of the test samples to Solar radiation degraded during space exposure in an unpredicted way. Several windows in front of the Sun-exposed test samples acquired a brown shade, resulting in a reduced transparency in visible light, UV and vacuum UV (VUV). Post-flight investigations revealed the discolouration to be caused by a homogenous film of cross-linked organic polymers at the inside of the windows. The chemical signature varied per sample carrier. No such films were found on windows from sealed, pressurized compartments, or on windows that had been kept out of the Sun. This suggests that volatile compounds originating from the interior of the Expose facility were cross-linked and photo-fixed by Solar irradiation at the rear side of the windows. The origin of the volatiles was not fully identified; most probably there was a variety of sources involved including the biological test samples, adhesives, plastics and printed circuit boards. The outer surface of the windows (pointing into space) was chemically impacted as well, with a probable effect on the transparency in VUV. The reported analysis of the window contamination on Expose-R is expected to help the interpretation of the scientific results and offers possibilities to mitigate this problem on future missions - in particular Expose-R2, the direct successor of Expose-R.

  19. Mesophilic and thermophilic anaerobic co-digestion of abattoir wastewater and fruit and vegetable waste in anaerobic sequencing batch reactors.

    Science.gov (United States)

    Bouallagui, Hassib; Rachdi, Boutheina; Gannoun, Hana; Hamdi, Moktar

    2009-06-01

    Anaerobic co-digestion of fruit and vegetable waste (FVW) and abattoir wastewater (AW) was investigated using anaerobic sequencing batch reactors (ASBRs). The effects of hydraulic retention time (HRT) and temperature variations on digesters performances were examined. At both 20 and 10 days biogas production for co-digestion was greater thanks to the improved balance of nutrients. The high specific gas productions for the different digestion processes were 0.56, 0.61 and 0.85 l g(-1) total volatile solids (TVS) removal for digesters treating AW, FVW and AW + FVW, respectively. At an HRT of 20 days, biogas production rates from thermophilic digesters were higher on average than from mesophilic AW, FVW and AW + FVW digestion by 28.5, 44.5 and 25%, respectively. However, at 10 days of HRT results showed a decrease of biogas production rate for AW and AW + FVW digestion processes due to the high amount of free ammonia at high organic loading rate (OLR).

  20. Changes of Blood Lead and Oxidative Stress Enzymes among the Workers Exposed to Lead%铅作业工人血铅和氧化应激酶变化的研究

    Institute of Scientific and Technical Information of China (English)

    裘淑华; 邹华; 何晓庆

    2009-01-01

    Objective To study oxidative damage for occupational lead exposure, the relationship between serum lead and oxidative stress enzymes, and the mechanism of lead poisoning. Methods The lead content in the air was determined by flame atomic absorption spectrophotometric method, the lead concentration in serum was determined by graphite furnace atomic absorption spectrophotometric method. Superoxide dismutase (SOD) and malondialdehyde (MDA) as the effect indicators of oxidative stress were used to analyze the relationship between blood lead and the indicators. Results Five workplaces were monitored. The lead concentration in exposed group (244.27±124.59ug/L) was significantly higher than that in control group (P0.05), while MDA concetration in exposure group (9.42±3.89mmol/L) was significantly higher than in control group (P0.05);接触组MDA含量(9.42±3.89)mmol/L,显著高于对照组(P<0.01);血清MDA含量与血铅之间存在正相关关系(r=0.3,P<0.01);吸烟、饮酒对SOD活性和MDA含量影响无统计学差异.结论 职业性铅接触引起人体血铅升高,作业场所空气中铅浓度与血铅含量变化不一致,血铅是近期铅接触者的敏感内接触指标,且血铅浓度越高,SOD活性代偿性升高;MDA含量越高,氧化损伤越明显.

  1. Managing workers' compensation exposures in healthcare.

    Science.gov (United States)

    McDonald, L

    1998-01-01

    Employees in healthcare are exposed to numerous and varied risks that pose the threat of injury. Management of those exposures by the organization will ultimately help create a safe environment for staff, patients and the public. Incorporating workers' compensation into the risk management program is the first step toward managing and reducing these exposures. This article presents a suggested outline for a written risk management plan for workers' compensation exposures. PMID:10182134

  2. 金属制造业噪声作业工人上岗前听力损失影响因素分析%Influence factors of hearing loss in pre-job workers exposed to noise in metal manufacturing industries

    Institute of Scientific and Technical Information of China (English)

    郭智屏; 邓燕君; 潘文娜; 刘新霞; 郑倩玲

    2016-01-01

    Objective To examine the hearing status of pre-job workers exposed to noise in metal manufacturing industries, and to analyze the related influencing factors .Methods A judgement sampling method was adopted to choose 1 597 pre-job workers exposed to noise in metal manufacturing industries as the study subjects .The data of workers ’ occupational health examination was collected , and the influencing factors of hearing loss were analyzed .Results Among the 1 597 individuals, 631 (39.5%) cases reported occupational noise exposure history (noise exposure group) with the length of service of 0.20 (0.10-0.30) years;966 (60.5%) cases denied occupational noise exposure history ( no-noise exposure group).The hearing loss detection rate was 46.1%(737/1 597);among them, the occupational contraindication detection rate was 13.9%(222/1 597), and the detection rate of other kinds of hearing loss was 32.2%(515/1 597). The detection rates in workers with occupational contraindication and the other kinds of hearing loss in noise exposure group were higher than those in the non-noise exposure group ( 16.5% vs 12.2%, 50.6% vs 43.3%, P25 years had higher incidence than those with age ≤25 years ( OR were 2.390 and 2.245, respectively, P<0.01);the noise exposure workers had higher incidence than non-noise exposure ones (OR were 1.536 and 1.287, respectively, P<0.05).Conclusion Pre-job occupational health examination is helpful for early detection of occupational contraindication in noise exposure workers .Attention should be paid to the male workers , the older workers, and those with occupational noise exposure history when conducting occupational health examination .%目的:了解金属制造业噪声作业工人上岗前听力损失情况,分析其影响因素。方法采用判断抽样的方法,以1597名行上岗前职业健康检查的金属制造业拟从事噪声作业的工人为研究对象,收集其上岗前职业健康检查的相关资料,分析其听力损

  3. 发中锌铜铁含量变化对三硝基甲苯职业损伤的提示作用%Indications of occupational damage caused by the changes of zinc,copper and iron contents in hair among male workers exposed to trinitrotoluene

    Institute of Scientific and Technical Information of China (English)

    李芝兰; 李顺民; 米发泰

    2004-01-01

    BACKGROUND: The mechanism of trinitrotoluene (TNT) poisoning is still not clear. Although the TNT content in the air of workshops is kept under the national healthy standard (1 mg/m), poisoning still occurs among the workers exposed to TNT. so it is very. necessary to study the preventive mechanism of this kind of professional injury.OBJECTIVE: Seeking for some new useful biological monitoring indices for the occupational TNT exposure, to prevent TNT chronic poisoning and provide theoretical basis for the early intervention of occupational diseases.DESIGN: A non-randonized controlled study.SETTING, PARTICIPANTS and INTERVENTIONS: In Lanzhou Trinitrotoluene Chemical Plant, 44 male workers exposed to TNT were chosen from Workshop No. 1 engaged in TNT operations. 13 non-exposed controls were selected from the Workshop No. 2 without TNT exposure. Cutting the hair at the site of occiput of the head with the scissors kept close to the hair roots. Atomic absorption spectrophotometry. were conducted to determinate the contents of zinc, copper and iron contents in hair of the workers.MAIN OUTCOME MEASURES: The contents of zinc, copper and iron in hair of the two groups.RESULTS: The mean of tle hair copper was 20. 50 μg/g, significantly higher than 18.26 μg/g in the controls (t = 2. 159, P <0.05), while the hair zinc and iron contents between the exposed and non-exposed groups demonstrated no significant differences statistically ( P > 0.05). However,the hair zinc levels have revealed a well established dose-effect relationship with the TNT levels in the air of workshops( r = 0. 917, P < 0.05).CONCLUSION: Tle hair zinc level might be adopted as a biological monitoring index under certain circumstances. The content of copper in hair has an indication of occupational damage for workers exposed to TNT, and it can be used as an early intervention for the occupational damage.%背景:三硝基甲苯(trinitrotoluene,TNT)中毒机制至今尚未研究清楚.尽管车间空

  4. Radium dial workers

    International Nuclear Information System (INIS)

    The population of radium dial workers who were exposed to radium 30 to 50 years ago are currently being followed by the Center for Human Radiobiology at the Argonne National Laboratory. It is not clear that radium has induced additional malignancies in this population, other than the well-known bone sarcomas and head carcinomas, but elevated incidence rates for multiple myeloma and cancers of the colon, rectum, stomach, and breast suggest that radium might be involved. Continued follow-up of this population may resolve these questions. Finally, the question of the effect of fetal irradiation on the offspring of these women remains to be resolved. No evidence exists to suggest that any effects have occurred, but there is no question that a chronic irradiation of the developing fetus did take place. No formal follow-up of these children has yet been initiated

  5. Reducing workers' compensation costs.

    Science.gov (United States)

    Killian, M J

    1994-01-01

    Employers can reduce their workers' compensation costs by encouraging internal communication and education before and after injuries occur. Comprehensive workers' compensation programs can be developed by integrating the management of employee benefits and workers' compensation claims. PMID:10133659

  6. Asthma and other symptoms in cinnamon workers.

    OpenAIRE

    Uragoda, C G

    1984-01-01

    Cinnamon, which is the bark of the Cinnamomum zeylanicum tree, contains cinnamic aldehyde, which is an irritant. Workers processing cinnamon before export are exposed to much cinnamon dust. Forty such workers with an average of four years' service in the industry were examined. Thirty five workers (87.5%) had symptoms, nine having had asthma (22.5%). Other symptoms, probably related to the irritant nature of cinnamon dust, were irritation of skin (50%), loss of hair (37.5%), and smarting of e...

  7. An untold story in labor health: Korean women workers.

    Science.gov (United States)

    Kim, Myoung-Hee; Kim, Hyun-joo

    2007-01-01

    Very little is known about labor health among Korean women workers, who have been left behind by the occupational safety and health institutions. In this article, we examine, from a gender perspective, the occupational safety and health (OSH) statistics, institutions, and the struggles of women workers, and discuss how to make a society where women workers become and stay healthy. The problems Korean women workers face have both universal and unique aspects. On the one hand, they tend to be exposed to "invisible hazards" and to disproportionately suffer from neo-liberal policies, as do women workers in other countries