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Ristorante, Marcos

2016-07-01

Full Text Available FRADKIN, Raúl Osvaldo y GELMAN, Jorge Daniel; Juan Manuel de Rosas: La construcción de un liderazgo político; Buenos Aires. Edhasa, 2015 KOLLOTAY, Alexandra. Catorce conferencias en la Universidad Sverdlov de Leningrado (1921 Mujer. Economía. Sociedad, Cienflores, Buenos Aires, 2014 ARGIROFFO, Beatriz y SCALONA, Elvira (compiladoras; Educación Sexual Integral y enseñanza de las Ciencias Sociales. Enfoques, sujetos y objetos para su abordaje en la escuela secundaria. Ed. Coad y Amsafe Rosario, Rosario, 2016, 176 pp.

Éter: de la Res Extensa a la Inteligencia Ambiental

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Juan Elvira

2015-05-01

Full Text Available Juan Elvira es profesor Asociado de Proyectos Arquitectónicos en la ET­SAM (2001-. Becado por La Caixa para realizar el Máster por la Universi­dad de Columbia de Nueva York (Ad­vanced Architectural Design, 2000. Profesor en el IE University desde 2013. Profesor invitado en diversas universidades nacionales e internacio­nales, como la NTNU de Trondheim, la Universidad Internacional de Cataluña, el Istituto Europeo di Design o la EA de Alicante, donde condujo la investi­gación “Espacios Tácticos” presentada en Archilab’02. Los proyectos de Murado&Elvira han sido premiados en concursos nacionales e internaciona­les, y expuestos, entre otros, en Fresh­madrid y en la undécima Mostra Inter­nazionale de Architettura di Venezia. Recientemente ha finalizado, fruto del concurso EuropanIX, la construcción de una residencia de estudiantes y un eje verde urbano en Trondheim, nominados para el Premio Nacional de Arquitectura de Noruega (2012 y seleccionados en la Bienal de Arqui­tectura Española (2013. Lleva a cabo una labor crítica y editorial que comen­zó como director de la revista Oeste de Arquitectura, seguida por la publica­ción de numerosos ensayos en libros y revistas especializadas. Leerá en breve su tesis doctoral, Arquitectura Fantas­ma, una investigación sobre la práctica cultural y tecnológica de la producción de efectos ambientales arquitectónicos.

Genotoxic effects and gene expression in Danio rerio (Hamilton 1822) (Cypriniformes: Cyprinidae) exposed to mining-impacted tributaries in Manizales, Colombia.

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Ossa-López, Paula A; Castaño-Villa, Gabriel J; Rivera-Páez, Fredy A

2017-09-25

The zebrafish (Danio rerio) is one of the most studied aquatic organisms for water biomonitoring, due to its sensitivity to environmental degradation and resistance to toxic substances. This study determined the presence of micronuclei and nuclear abnormalities in peripheral blood erythrocytes, and assessed the gene expression of caspase-3 (CASP-3) and metallothionein 1 (MT-1) in the gills and liver of D. rerio. The study fish (n = 45) were exposed to water collected from two stations with mining impact (E2 and E3) and a reference station without evident mining contamination (E1), all located in La Elvira stream (Manizales-Colombia). In addition, a positive control (PC) with HgCl 2 (50 μg/L) and negative control (NC) with tap water were included. The fish from the PC and E2 and E3 treatments displayed genotoxic effects and changes in gene expression, with significant differences in micronuclei formation and the presence of blebbed nuclei. The cytochrome oxidase subunit I (COI) gene was used as reference and proved to be stable compared to the β-actin and 28S ribosomal RNA (28S) genes. In gills, CASP-3 expression was higher in the PC, and MT-1 expression was higher in the PC and E3 treatment. In liver, CASP-3 was expressed in the E2 treatment, and MT-1 expression was low. These results show that the genotoxic effects and differential gene expression observed in fish exposed to water from La Elvira stream could also be affecting the organisms present in this habitat.

Precise determination of the f0(500) and f0(980) parameters in dispersive analysis of the ππ data

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Kamiński, Robert; Garcia-Martin, R.; Pelaez, J.R.; Ruiz de Elvira, J.

2013-01-01

Use of the new and precise dispersive equations with imposed crossing symmetry condition to solve the long-standing puzzle in the parameters of the f 0 (500), as well as the f 0 (980) is presented. This puzzle is finally being settled thanks to analyzes carried out during the last years [J. Beringer et al. (Particle Data Group), Phys. Rev. D86, (2012) 010001]. In this report we show how our very recent dispersive data analysis allowed for a precise and model independent determination of the amplitudes for the S, P, D and F waves [R. Garcia-Martin, R. Kaminski, J. R. Pelaez, J. Ruiz de Elvira and F.J. Yndurain, Phys. Rev. D83, (2011) 074004; R. Garcia-Martin, R. Kamiński, J.R. Pelaez and J. Ruiz de Elvira, Phys. Rev. Lett. 107, (2011) 072001; R. Kamiński, Phys. Rev. D83, (2011) 076008]. Especially we present that the analytic continuation of once subtracted dispersion relations for the S 0 wave to the complex energy plane leads to very precise results for the f 0 (500) pole: √(s pole )=457 −13 +14 −i279 −7 +11 MeV and for the f 0 (980) pole: √(s pole )=996±7−i25 −6 +10 MeV. We also mention on first (or one of the first) practical application of presented dispersion relations in refitting and in significant improving of the ππ S-wave amplitudes below 1000 MeV

EL MÁS DESGRACIADO

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Luis I. Guerrero

2013-11-01

Full Text Available The author comments on the poetic category in the aesthetic from the reflexion on the female characters that were prey of the powers of seduction: Donna Elvira of Mozart's Don Giovanni, Maria Deaumarchais of Goethe's Clavijo, and John's Cordelia from the Diary of a Seducer. These female figures, whose poetic force is comparable to the one of Antigone, are different because of the power of seduction, for in these stage the pathetic female response does not consist in seeking for the oblivion and the relief of their sorrow, but in the remembrance and the pain of their most precious treasure.

Present i futur en el periodisme de dones

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Altés, Elvira

2008-01-01

En aquestes pàgines, es mostren les conclusions a les quals va arribar la professora Elvira Altés i el seu equip d’investigació dins el marc del Projecte Global dels Mitjans. Unes conclusions poc alentadores pel fet que, malgrat haver aconseguit introduir-se en les redaccions, les dones no han capgirat la desigualtat de gènere en la seva feina. Efectivament, en aquesta professió s’evidencia una força centrífuga que allunya les dones dels llocs de poder. La coneguda metàfora del sostre de vidr...

Boletim Epidemiológico Observações: Vol. 5 (2016), Número Especial 8, Alimentação e Nutrição

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Instituto Nacional de Saúde Doutor Ricardo Jorge

2016-01-01

Ficha técnica: Diretor: Fernando de Almeida; Editores:Carlos Matias Dias, Elvira Silvestre; Conselho Editorial Científico: Carlos Matias Dias, Manuela Cano, Jorge Machado, Manuela Caniça, Peter Jordan, Sílvia Viegas, Luciana Costa. Número Especial dedicado à Alimentação e Nutrição do Boletim Epidemiológico Observações. Observações é uma publicação científica do INSA, IP, que visa contribuir para o conhecimento da saúde da população, os fatores que a influenciam, a decisão e a intervenção e...

Glossed chronology about November 30th Memorial Acts in Santiago De Cuba from 1959 until 2001

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Odalys Marqués-Marqués

2016-12-01

Full Text Available The present text resumes the interes for the way in which Santiago’s people offers tribute to one of the most importante achievment of city fighting History, in order to conquer the definitive independence. This already is a Santiago’s people tradition. The informational research work in order to elaborate the chronology, took into account Elvira Cape Main Library’s Hemerotec and Rare and Valuable Funds departments. Magazines and Journals of provincial and national coverage were consulted, and the chronicles and visitors’ book at Lucha Clandestina Museum, opened at November 30th, 1976. 

Mitte-eestlastest noorte kohanemine eestikeelses töökeskkonnas / Elvira Küün

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Küün, Elvira

2006-01-01

Noorte mitte-eestlaste hakkamasaamisest Eestis pärast venekeelse kooli lõpetamist, väljavaated tööturul ning kohanemisest eestikeelses töökeskkonnas. Võrreldud on Tallinnast ja Ida-Virumaalt pärit noorte sotsiaalset adaptatsiooni

Libros

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Enrique Cantera Montenegro

2001-01-01

Full Text Available RESEÑA 1 de : Palacios Martín, Bonifacio. Colección Diplomática Medieval de la Orden de Alcántara (11577-1494. Tomo I : de los orígenes a 1454. Madrid : Fundación San Benito de Alcántara-Editorial Complutense, 2000. RESEÑA 2 de : Benito Ruano, Eloy; del Valle R., Carlos; Formentín Ibáñez, Justo; Howel, Victoria; Llamedo González, Juan José; Martínez Casado, Ángel; Pérez Ferreiro, Elvira; Velasco Delgado, Argimiro. Tratado contra los madianitas e ismaelitas, de Juan de Torquemada. Madrid : Aben Ezra Ediciones, 2002.

A migrante e o xamã: agentes transculturadores em dois romances italianos contemporâneos The migrant and the shaman: transcultural agents in two contemporary italian novels

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Ana Maria Chiarini

2012-12-01

Full Text Available A proposta deste trabalho é evidenciar a função transculturadora exercida por trabalhadoras migrantes na Itália contemporânea, vista como espaço da diáspora, nos romances Apri le porte all'alba (1999, de Elena Gianini Belotti, e L'indecenza (2008, de Elvira Seminara. Essas personagens sociais - participantes de trocas interculturais e intercorporais - vêm se tornando personagens literárias e, embora reduzidas a não-pessoas ou marcadas por um pretenso núcleo étnico essencial, ativam as forças diferenciadoras e transgressoras da homogeneidade cultural globalizada, citadas por Hall (2003. Visando acentuar esse papel da migrante, utilizo a figura do xamã no drama existencial mágico e na crise da presença, tratados por Ernesto de Martino, um dos fundadores da antropologia italiana, em Il mondo magico (1948.The aim of this work is to focus attention on the transcultural role played by female migrant workers in contemporary Italy, seen as a diasporic space, in the novels Apri le porte all'alba (1999, by Elena Gianini Belotti, and L'indecenza (2008, by Elvira Seminara. These social characters - participants in intercultural and interbodily exchanges - have become literary characters, and even though they are reduced to non-people or marked by a supposed essentialist ethnic center, they stimulate the differential and transgressive forces of a globalized cultural homogeneity, as stated by Hall (2003. In an attempt to highlight this role of the migrant, I make use of the shaman figure in the magic existential drama and in the crisis of presence, discussed by Ernesto de Martino, one of the founders of the Italian anthropology, in Il mondo magico (1948.

La emergencia del feminismo en la Argentina: un análisis de las tramas discursivas a comienzos del siglo XX

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Natalia Martínez Prado

2015-03-01

Full Text Available En el presente artículo nos propusimos reconstruir algunos de los sentidos dominantes que adquirieron las primeras prácticas reconocidas como “feministas” a partir de una aproximación a sus (des articulaciones con otras prácticas femeninas. Sosteniendo una concepción anti-esencialista, relacional y radical de la identidad, nuestro análisis se detiene en la lectura de dos corpus textuales de las activistas a comienzos del siglo XX. Analizamos el discurso de las anarquistas desde el periódico: “La Voz de la Mujer” y nos detenemos en la tesis doctoral de Elvira López, defendida en 1901 y titulada: “El movimiento feminista. Primeros trazos del feminismo en Argentina”.

Cinquentenário do "Manual de Técnica de Enfermagem" (1957-2007: contribuições na construção do saber de enfermagem Los cincuenta años del "Manual de Procedimientos de la Enfermería" (1957-2007: contribuciones a la construcción de conocimientos de la enfermería Fiftieth anniversary of the "Manual de técnica de enfermagem" [1975-2007]: contributions to nursing knowledge construction

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Ive Cristina Duarte de Lucena

2010-03-01

Full Text Available Trata-se de um estudo histórico social que tem como objetivos: descrever a trajetória da professora Elvira De Felice Souza (EFS; analisar o conteúdo do "Manual de Técnica de Enfermagem", escrito por EFS; e discutir a contribuição histórica desta obra para a bibliografia brasileira de enfermagem. O referencial teórico são as fases da construção do saber de enfermagem. Verificou-se que a obra de EFS veio avançar a produção bibliográfica brasileira a respeito da execução dos procedimentos técnicos de enfermagem, que à época se expressava por uma única autora brasileira. Somaram-se mais de quatro décadas desde sua utilização pelas alunas de enfermagem (1953, e, até sua última reimpressão (1995, a obra atravessou periódica atualização, chegando a ser o principal guia para a execução dos procedimentos pelas alunas de fundamentos de enfermagem, tendo sido utilizada por enfermeiros do Brasil inteiro para a elaboração de diversos manuais de enfermagem.Es es un estudio histórico y social, que tiene como objetivos: describir la trayectoria de la profesora Elvira De Felice Souza (EFS; analizar el contenido del "Manual de Procedimientos de la Enfermería", escrito por EFS; discutir la contribución histórica de este trabajo a la bibliografia brasileña del área de enfermería. El referencial teórico está constituído por las etapas de construcción de conocimientos de enfermería. Se constató que la obra de EFS ayudó al avance de la producción bibliográfica brasileña en relación a la ejecución de los procedimientos técnicos de enfermería, que en la época estaban expresados por una única autora brasileña. Pasaron más de cuatro décadas desde su uso por las estudiantes de enfermería (1953 hasta su última reimpresión (1995, recibiendo periódica actualización, y llegar a ser un guía principal para la aplicación de procedimientos por las estudiantes de fundamentos de enfermería, y fue utilizado por las

Tallinna Raekoda. Aeg ja lugu = Tallinn Town Hall - Its Story Through Time / Elvira Liiver Holmström

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Liiver Holmström, Elvira

2004-01-01

Raekoja kujunemislugu. Esindussaalid, ameti- ja tarberuumid. Raekoda 17.-20. sajandil. Hoone ümberehitamist 1402-1404 juhtis kiviraidur Ghercke. Hinrik Hartmanni poolt valatud kell paigutati torni 1586. a. 17. sajandil tegi hilisrenessanss-stiilis torni joonised Geiger Graff, lääneviilule uue harjakivi ja tuulelippu hoidva lõvi Hans Damm, lohepeakujulised veesülitid ja tuulelipu lipu Daniel Pöppel, raesaali paigutati Johann Akeni lünettmaalid, nende all paikneva puitnikerdfriisi valmistasid Elert Thiele ja Joachim Armbrust. 1859. a. ümberehitusprojekti koostas Christoph August Gabler

Avaliação do impacto da polimedicação nas verbas de internamento nas unidades de longa duração e manutenção Evaluación del impacto de la polimedicación sobre la financiación de las unidades de hospitalización y mantenimiento a largo plazo Assessment of the impact of polypharmacy on funding for admission in a long-term care and maintenance unit

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Nelson Manuel de Lima Ferreira

2012-03-01

Full Text Available Contexto: a falência dos estados de providência obriga a que seja efetuada uma reflexão e análise cuidada de todo o campo da saúde para que a sua sustentabilidade seja possível. Em Portugal verifica-se, como em toda a Europa, um progressivo envelhecimento da população, consequência do aumento da esperança média de vida e da baixa natalidade. Objetivos: avaliar o impacto da polimedicação nas verbas diárias de internamento imputadas a uma unidade de longa duração e manutenção. Método: tratou-se de um estudo de caso, de natureza exploratória, junto de 65 utentes, admitidos na Unidade de Longa Duração e Manutenção Dona Elvira da Câmara Lopes da Santa Casa da Misericórdia da Póvoa de Lanhoso. Resultados: existe polimedicação major nesta população, nomeadamente, uma média de 6 medicamentos prescritos por utente. Fazendo o cálculo, em função de 10 EUR de verba diária atribuída, obtém-se a percentagem significativa de 37% de impacto na verba imputada pelo Estado. Conclusão: é preciso compreender os padrões de prescrição noutros contextos, assim como, conhecer as razões/motivos que levam à prescrição de mais do que um fármaco.Contexto: el fracaso de los Estados sociales obliga a que se entame una reflexión y un cuidadoso análisis de todo el campo de la salud para que su sostenibilidad sea posible. En Portugal hay, como en otras partes de Europa, un progresivo envejecimiento de la población, consecuencia de la mayor esperanza de vida y baja tasa de natalidad. Objetivos: evaluar el impacto de la polimedicación en los gastos diarios de ingreso imputados a una unidad de hospitalización de Largo Plazo y de Mantenimiento. Método: se realizó un estudio de caso de carácter exploratorio, con 65 usuarios, ingresados en la unidad de hospitalización a Largo Plazo y de Mantenimiento - Dona Elvira da Câmara Lopes de la Santa Casa da Misericórdia da Póvoa de Lanhoso. Resultados: hay una mayor polimedicaci

A teoria ambientalista de florence nightingale no ensino da escola de enfermagem Anna Nery (1962 - 1968 La teoría ambientalista de florence nightingale en la enseñanza de la escola de enfermagem Anna Nery (1962 - 1968 The environmental theory by florence nightingale in the teaching of the nursing school Anna Nery (1962 - 1968

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Veronica Cristin do Nascimento Haddad

2011-12-01

Full Text Available Estudo histórico-social. Objetivos: caracterizar a Teoria Ambientalista de Florence Nightingale e analisar a aplicação dos conceitos dessa teoria no ensino da disciplina "fundamentos de enfermagem" na EEAN. Fontes: quarta edição do "Novo Manual de Técnica de Enfermagem" de Elvira de Felice Souza, livros, leis, teses, dissertações, trabalhos científicos. O Manual apresenta princípios para a boa execução da assistência de enfermagem, citando ações que proporcionam ao doente bem-estar físico, mental e espiritual. Estes princípios corroboram os pensamentos de Florence Nightingale que denotam a importância da implementação de uma assistência caracterizada por condições de recuperação, cura e reabilitação relacionadas com a qualidade do ambiente. Conclusão: constatação de que o ensino na época focalizava não somente o desenvolvimento das técnicas de enfermagem de forma correta, mas também a prática de ações que garantissem o cuidado holístico através de uma assistência pautada nos valores morais da sociedade e pelos princípios éticos da profissão.Estudio histórico y social. Objetivos: Caracterizar la Teoría Ambientalista de Florence Nightingale y analizar la aplicación de sus conceptos en la enseñanza de la asignatura "Fundamentos de Enfermería" en EEAN. Fuentes: 4ª edición del "Nuevo Manual de Enfermería Técnica", de Elvira de Felice Souza, libros, leyes, tesis, disertaciones y trabajos científicos. El manual establece los principios para el buen desarrollo de los cuidados de enfermería, citando las acciones que le dan al paciente el bienestar físico, mental y espiritual. Estos principios están de acuerdo con el pensamiento de Florence Nightingale, que denota la importancia de implementar un servicio caracterizado por las condiciones de la recuperación, curación y rehabilitación relacionadas con la calidad del medio ambiente. Conclusión: la constatación de que la enseñanza de la �

La dramaturgia iconoclasta, cómica, conceptual y poética de Daniele Timpano. Entrevista al autor

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Daniele Timpano

2016-01-01

Full Text Available En la producción del actor y dramaturgo Daniele Timpano (Roma, 1974 se encuentran algunos de los espectáculos más interesantes de las últimas décadas, con títulos como Dux in scatola. Autobiografia d'oltretomba di Mussolini Benito (2006, sobre los avatares del cadáver del Duce; Ecce Robot (2007, una curiosa obra, en parte "autobiografía generacional", empapada de la tradición del cómic asiático; o Sì l'ammore no (2009, escrito junto a Elvira Frosini, con la que también ha escrito su más reciente Zombitudine (2013. La presente entrevista propone recorrer algunas de las etapas más sobresalientes de su producción, al tiempo que plantear la pertinencia o no de algunas cuestiones que gravitan sobre su obra, como son la pertenencia o no a una teórica non-scuola romana, o el supuesto carácter anti-narrativo de sus espectáculos.

(Relembrando Elvira de Felic: gestos e falas de enfermeiras sobre o banho no leito, uma técnica/tecnologia de enfermagem Reacordando Elvira de Felice: gestos y hablas de enfermeras sobre el baño en el lecho, una técnica/tecnología de Enfermería Remembering Elvira de Felice: gestures and speechs of the nurses about the bathing in the bed, a technique/technology of Nursing

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Nébia Maria Almeida de Figueiredo

2006-04-01

Full Text Available Trata-se de uma pesquisa quanti-qualitativa sobre banho no leito, com os objetivos de identificar expressões verbais e caracterizar expressões não verbais durante a execução da atividade de banhar e de ser banhada.. A coleta de dados incluiu o registro de falas, gestos e expressões durante a Cena de Reflexão, uma dramatização do banho em sala de aula, com a participação de 32 enfermeiras e alunas de pós-graduação - mestrado. Os resultados indicaram dois núcleos de representações: o primeiro, "O Corpo que Toca e Fala"; e o segundo, "O Corpo que Toca e Cala". A Multireferencialidade, Subjetividade, Psicossociologia e as concepções de Nightingale, Figueiredo e Carvalho foram usadas como apoio teórico. Os resultados constataram dificuldades das enfermeiras em relação ao toque e ao corpo nu, durante o procedimento técnico, e também quando opinavam e defendiam, de fato, o próprio corpo e o toque como intermediadores de emoções, subjetividade, estética, sexualidade e sensualidadeSe trata de una investigación cuanti-cualitativa sobre el baño en el lecho, con los objetivos de identificar expresiones verbales y caracterizar expresiones no verbales durante la actividad de bañar y de ser bañada. La recolección de datos incluyó el registro de hablas, gestos y expresiones durante la Escena de Reflexión, una dramatización del baño en clase, con la participación de 32 enfermeras ya alumnas de posgrado (Maestría. Los resultados indicaron dos núcleos de representaciones: "El cuerpo que toca y habla" y "El cuerpo que toca y calla". La Multireferencialidad, Subjetividad, Psicosociología y las concepciones de Nightgale, Figueiredo Y Carvalho fueron usadas como soporte teórico. Se constató dificultades de las enfermeras en relación al toque y al cuerpo desnudo en el decurso del procedimento técnico, y también cuando opinaban y defendían, en realidad, el propio cuerpo y el toque como intermediadores de emociones, subjetividad, estética, sexualidad y sensualidadThis is about a quantitative and qualitative research about the bath in the bed, with the objectives to identify verbal expressions and to characterize not verbal expressions during the execution of the activity to bathe and of being bathed. The collection of data included the register of speechs, gestures and expressions during the Scene of Reflection, a dramatization of the bath in classroom, with the participation of 32 nurses and students of Postgraduation - masters. The results had indicated two nuclei of representations: the first one, "the Body that Touchs and Speaks"; and the second one, "the Body that Touchs and Quiet". The Multireferentiality, Subjectivity, Psychosociology and the conceptions of Nightingale, Figueiredo and Carvalho had been used as theoretical support. The results had evidenced difficulties of the nurses in relation to the touch and to the naked body, during the technician procedure, and also when they thought and they defended, in fact, the proper body and the touch as intermediate of emotions, subjectivity, aesthetic, sexuality and sensuality.

Evaluation of the Possibility of Cultivation of Eggplant and Common Vetch in a Mercury Contaminated Area; Evaluacion de la posibilidad de cultivo de veza y berenjena en un area contaminada con mercurio

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Sierra, M J; Millan, R; Esteban, E

2006-12-18

This study is framed in the project Recuperacion de Terrenos Afectados por Mercurio Ambiental (RETAMA) which determines the behaviour of mercury in the soil-plant system within the area of Almaden. It forms part of experimental work of doctoral thesis carried out by Maria Jose Sierra and directed by Rocio Millan and Elvira Esteban. The objective of this work was to study the mercury absorption capacity of Solanum melongena (eggplant) and Vicia sativa (common vetch), and the distribution of this metal in this crop. The possible use of eggplant culture as an economic alternative in a mercury contaminated area has been evaluated. The present study has been carried out using a soil from the mercury mining district of Almaden (Spain). The total mercury concentration of this soil is 14.16 + 0.65 mg kg-1 on average. The selected crops are typical in the area of study, eggplant is much appreciated for human consumption and common vetch is an important forage crop. At the end of the document (Anexo V) a critical reading of several articles related to the study subject have been enclosed. (Author) 50 refs.

Il mito di Lope de Aguirre in due opere della drammaturgia franchista e postfranchista

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Arianna Fiore

2016-12-01

Full Text Available Twentieth-century Spanish theatre is often inspired by the figure of Lope de Aguirre, with motifs and modes that change depending on time, considering 1939 and 1975 two crucial watershed moments in the cultural history of the Iberian Peninsula. The dramatic works analysed date back precisely to the years of Franco’s dictatorship and the democratic period: in 1941 Gonzalo Torrente Ballester was the first twentieth-century dramatist to devote a text, entitled Lope de Aguirre, to the life of the Basque conqueror. The work, for reasons that will be explored in the present essay, was never staged in Franco’s time: Ballester’s Aguirre is a romantic hero who defies the king to defeat the injustices which he is forced to witness, and everyone, men, women, blacks, indios, will at last be free under his red-black banner. Dona Elvira, Imaginate Euskadi (1985, by Ignacio Amestoy Egiguren, is the first published work in the democratic era. It can be read as a great metaphor of the Basque issue, the tragedy of Euskadi and the climate of violence and tension that characterized the Basque Country in the 1980s.

Habilidades metacomprensivas en estudiantes de profesorado: la formulación de preguntas Metacomprehension Abilities in Students of Teaching: Question Making

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Elvira Arnoux

2007-06-01

Full Text Available Ante las crisis de la institución escolar y las propuestas recurrentes de reformas de leyes educativas, resulta imprescindible la elaboración de diagnósticos sobre problemas de alumnos y docentes, entre otras cuestiones. Para hacer un aporte en este sentido, un equipo de investigación dirigido por la profesora Elvira Arnoux, en el Instituto de Lingüística de la Universidad de Buenos Aires, ha diseñado y administrado una encuesta sobre lectura y una prueba de comprensión y metacomprensión para un nivel de educación superior que ha sido objeto de escasos trabajos de investigación: los alumnos de institutos de formación docente para los niveles inicial, primario y secundario de la provincia de Buenos Aires (Argentina.En el presente artículo se presenta esa prueba y se exponen los resultados de la sección en que se evalúa metacomprensión, centrada, en este caso, en la formulación de preguntas, uno de los componentes fundamentales en el aprendizaje de estrategias comprensivas. El análisis revela que los futuros docentes tienen competencias metacognitivas bajas, ilusión de conocimiento y serias dificultades para, a partir de un texto escrito, hacer preguntas que superen la aclaración de problemas léxicos. Del diagnóstico se infieren posibles características de la enseñanza de la lectura que desarrollarán los futuros docentes.Having on mind the existence of crises and recurrent projects for the education laws renewal, the making of diagnoses about students' and teachers' problems, among other issues, is imperative. In order to make a contribution in this sense, a team of researchers led by professor Elvira Arnoux at Lingüistics Institute, in Buenos Aires University, has designed and administrated a reading survey and a test on comprehension and metacomprehension in a postsecondary education level, which has been the research problem of a few studies: students at teachers training institutes for initial, primary and secondary

Cyberprotests and the (penal code Ciberaprotestas y código (penal

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Edición Activismo y Movimientos sociales

2012-06-01

Full Text Available Given the current turmoil of demonstrations and social protests that use Internet social networks as means of dissemination and organization, it seems Westerns governments are testing or trying to develop new measures of social control via modification of their legal codes. This article explores the situation of Spain in this respect, through four short interviews with communication and new media professionals: Elvira Huelbes (Journalist at Cuarto Poder, Jaime Pastor (Political Sciencies Professor in UNED, Javier de la Cueva (Lawyer specialized in ICTand Miguel Romero (Editor of Viento Sur.Las amplias y aceleradas transformaciones sociales y tecnológicas sucedidas de las últimas décadas están produciendo en la coyuntura de crisis importantes reacomodos globales en los sistemas productivos que empiezan a tener efectos políticos en la institucionalidad democrática configurada desde la posguerra europea. Parece emerger un ciclo de contestación con un sensible aumento de las movilizaciones en un número crecientes de países, en el que las redes sociales telemáticas contribuyen a un aumento de la capacidad de difusión y coordinación de unos movimientos sociales que, con su trabajo en red diversifican, repertorios de protestas y propuestas de alcance transnacional.

Posttraumatic stress symptoms, dissociation, and alexithymia in an Italian sample of flood victims

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Craparo G

2014-11-01

Full Text Available Giuseppe Craparo,1 Alessio Gori,2 Elvira Mazzola,1 Irene Petruccelli,1 Monica Pellerone,1 Giuseppe Rotondo3 1Faculty of Human and Social Sciences, Kore University of Enna, Enna, Italy; 2Department of Psychology, University of Florence, Florence, Italy; 3Department of Psychology, Unit of Psychotraumatology, San Raffaele Giglio Hospital of Cefalù, Cefalù, Italy Background: Several studies have demonstrated a significant association between dissociation and posttraumatic symptoms. A dissociative reaction during a traumatic event may seem to predict the later development of posttraumatic stress symptoms. Moreover, several researchers also observed an alexithymic condition in a variety of traumatized samples.Methods: A total of 287 flood victims (men =159, 55.4%; women =128, 44.6% with an age range of 17–21 years (mean =18.33; standard deviation =0.68 completed the following: Impact of Event Scale–Revised, Dissociative Experiences Scale II, Twenty-Item Toronto Alexithymia Scale, and Peritraumatic Dissociative Experiences Questionnaire.Results: We found significant correlations among all variables. Linear regression showed that peritraumatic dissociation plays a mediator role between alexithymia, dissociation, and posttraumatic stress symptoms.Conclusion: Our results seem to confirm the significant roles of both dissociation and alexithymia for the development of posttraumatic symptoms. Keywords: peritraumatic dissociation, posttraumatic symptoms, PTSD

Riscrivere la storia. Modalità di rappresentazione del colonialismo italiano in Albania

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Daniele Comberiati

2013-07-01

Full Text Available Departing from the contemporary work of migrant authors of Albanian origin − OrnelaVorpsi, Anilda Ibrahimi and Elvira Dones − as well as from the theatrical monologueItalianesi by Saverio La Ruina, this article delves into the question of identity within postcolonial discourse. What role, in fact, do the Italian colonizers that remainedbehind in the liberated colonies play? How does their ‘hybrid’ identity help us toreflect upon colonial violence and upon the difficulties the colonizers themselves would have experienced internally when faced with accepting this violence? Additionally, the specific discussion of Albania, vis-à-vis narratives of contemporary migrants, allows us to reflect upon the Italian situation in particular, which, from unification to the present day offers specific material for the discussion of the relationship to, and the confronting of, the theme of ‘otherness’. A broad definition of ‘European’ colonialism − that goes beyond the alleged African otherness and runs along the same lines as a redefinition vehemently proposed by new groups of migrants in Italy (in particular by those from the Albanian immigration wave of 1991− allows one to question the Italian ambitions in regards to the Balkans and the Eastern expansion across national borders.

Avaliação de herbicidas de pós-emergência na cultura da batata Evaluation of herbicides on post emergent weed control in potato crops

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Jeferson Zagonel

1999-03-01

Full Text Available O experimento foi instalado na Fazenda Escola da UEPG, Ponta Grossa-PR, em solo Latossolo Vermelho Escuro de textura média argilosa, tendo como objetivo avaliar a eficiência e a seletividade do herbicida propaquizafop no controle pós-emergente de plantas daninhas na cultura da batata. O delineamento experimental foi de blocos ao acaso com seis tratamentos: propaquizafop (100, 125 e 150 g i.a./ha; fluazifop-p-butil (188 g i.a./ha; testemunha capinada e testemunha sem capina, em quatro repetições. O plantio foi realizado em 26 de outubro com a cultivar Elvira, usando-se o espaçamento de 0,70 x 0,35 m. As plantas daninhas presentes foram: Brachiaria plantaginea (capim-papuã, Digitaria horizontalis (capim-milhã e Eleusine indica (capim pé-de-galinha. As avaliações foram efetuadas aos 15, 30 e 45 dias após a aplicação dos tratamento. Observou-se que a aplicação de herbicidas pós-emergentes após a amontoa, permite controle adequado de plantas daninhas desde a emergência até a colheita; o herbicida propaquizafop mostrou-se eficiente no controle sobre capim-papuã e capim pé-de-galinha nas doses de 100, 125 e 150 g i.a./ha e sobre capim-milhã nas doses de 125 e 150 g i.a./ha. As perdas na produção causadas pela competição com plantas daninha foram da ordem de 57,4 %. Não foram observados efeitos fitotóxicos nas plantas de batata que pudessem ser atribuídos aos tratamentos aplicados.The presented field experiment was conducted at the Universidade Estadual de Ponta Grossa, Paraná State, Brazil, on Dark Red Latossoil, to evaluate the efficiency and selectivity of herbicides on post emergence weed control in potato crops. The experiment was laid out in a randomized block design with six treatments and four replications: propaquizafop (100, 125 and 150 g a.i/ha; fluazifop-p-butil (188 g a.i/ha, weed free and weedy. Planting was conducted on October 26, using the cultivar Elvira. Potato plants were spaced 0.70 x 0.35 m. The

Rezension von: Elvira Scheich, Karen Wagels (Hg.: Körper Raum Transformation. Gender-Dimensionen von Natur und Materie. Münster: Verlag Westfälisches Dampfboot 2011.

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Heinz-Jürgen Voß

2012-04-01

Full Text Available Öko-feministische Perspektiven wurden häufig als ‚essentialistisch‘ gekennzeichnet, und auch heute grenzt man sich gern mit diesem Vorwurf gegen sie ab. Der aktuelle Band Körper Raum Transformation. Gender-Dimensionen von Natur und Materie macht dagegen deutlich, wie brauchbar Perspektiven mit öko-feministischem Ausgangspunkt für aktuelle feministische und dekonstruktivistische Praxen und wissenschaftliche Analysen sein können. Für den Band gilt generell, dass an queere und postkoloniale Perspektiven und solche der ‚Krüppelbewegung‘ angeschlossen wird.

Dabrafenib: a new opportunity for the treatment of BRAF V600-positive melanoma

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Banzi M

2016-05-01

Full Text Available Maria Banzi,1 Simona De Blasio,2 Aimilios Lallas,3 Caterina Longo,2 Elvira Moscarella,2 Roberto Alfano,4 Giuseppe Argenziano5 1Department of Medical Oncology, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy; 2Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy; 3First Department of Dermatology, Aristotle University, Thessaloniki, Greece; 4Department of Anesthesiology, Surgery and Emergency, 5Dermatology Unit, Second University of Naples, Naples, Italy Abstract: Prior to 2011, the 1-year survival rates for patients suffering from advanced or metastatic melanoma was as low as 33%, with a median overall survival of about 9 months. Several chemotherapeutic regimens have been applied, either as monochemotherapy or as polychemotherapy, overall not resulting in an improvement of progression-free or overall survival. Novel insights into the epidemiology and biology of melanoma allowed the development of newer therapies. The discovery of mutations in BRAF, a part of the mitogen-activated protein kinase, allowed the development of two BRAF inhibitors, vemurafenib and dabrafenib, which significantly improved the outcome of metastatic melanoma treatment. This article reviews the mechanism of action, efficacy, and safety profile of dabrafenib. An in-depth knowledge of this medication will encourage clinicians to select the appropriate therapeutic strategy for each patient, as well as to prevent or adequately manage side effects, optimizing, thus, the drug’s applicability. Keywords: melanoma, BRAF, target therapy, dabrafenib, melanoma survival

In retrospect. 7th workshop RCA; Nachlese. 7. Workshop RCA. Conference report

Energy Technology Data Exchange (ETDEWEB)

Knappik, Reinhard [Verein fuer Kernverfahrenstechnik und Analytik Rossendorf e.V. (VKTA), Dresden-Rossendorf (Germany). Programmausschuss Workshop RCA

2013-08-15

The 7th Workshop RCA with 27 lectures and 12 poster presentation took place on 10 and 11 June 2013 in Dresden-Rossendorf. The traditional German event brought over 90 participants together from Germany, Austria, France, Switzerland and the Netherlands. This time the workshop put forward a special subject for the first time ('Obstacles and pitfalls when characterising waste packages'). A remarkable range of contributions was presented, which demonstrated the diversity and the problems of this subject matter. Medium to low radioactive waste and their final disposal was discussed. Other topics were the upcoming approval of recycling materials according to paragraph 29 StrlSchV as well as those from NORM (Naturally Occurring Radioactive Materials) regarding radionuclide analytics, the range of matrices to be processed and the practical problems this causes. Although the radiological feature was the central focus, other material aspects were dealt with, above all the approval of recycling materials when nuclear power plants are dismantled, but also in research institutes, which is demanding more and more attention. The lectures by Jessica Riemer (GSI Darmstadt) on the topic 'Waste material management of a research centre with heavy ion accelerators' and Elvira Mesalic (TU Munich) on 'Determining the activity inventory of bituminized old wastes' as well as the poster by Sina Brockmann on the 'Locally resolved analysis or uranium species using a couple systems of CLSM and LIFS' were awarded prizes for being outstanding presentations. (orig.)

In retrospect. 7th workshop RCA

International Nuclear Information System (INIS)

Knappik, Reinhard

2013-01-01

The 7th Workshop RCA with 27 lectures and 12 poster presentation took place on 10 and 11 June 2013 in Dresden-Rossendorf. The traditional German event brought over 90 participants together from Germany, Austria, France, Switzerland and the Netherlands. This time the workshop put forward a special subject for the first time ('Obstacles and pitfalls when characterising waste packages'). A remarkable range of contributions was presented, which demonstrated the diversity and the problems of this subject matter. Medium to low radioactive waste and their final disposal was discussed. Other topics were the upcoming approval of recycling materials according to paragraph 29 StrlSchV as well as those from NORM (Naturally Occurring Radioactive Materials) regarding radionuclide analytics, the range of matrices to be processed and the practical problems this causes. Although the radiological feature was the central focus, other material aspects were dealt with, above all the approval of recycling materials when nuclear power plants are dismantled, but also in research institutes, which is demanding more and more attention. The lectures by Jessica Riemer (GSI Darmstadt) on the topic 'Waste material management of a research centre with heavy ion accelerators' and Elvira Mesalic (TU Munich) on 'Determining the activity inventory of bituminized old wastes' as well as the poster by Sina Brockmann on the 'Locally resolved analysis or uranium species using a couple systems of CLSM and LIFS' were awarded prizes for being outstanding presentations. (orig.)

Ein Versuch, Naturverhältnisse aus feministischer Sicht zu interpretieren Another attempt to explain the natural environment from a feminist perspective

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Helga Purgand

2002-07-01

Full Text Available Mit dem vorliegenden Sammelband Geschlechterverhältnisse – Naturverhältnisse wird nach dem innovativen Beitrag der feministischen Debatte für umweltsoziologisches Denken gefragt und nach Überschneidungen, Grenzen und Zwischenräumen zwischen „Geschlecht“ und „Natur“ gesucht. In ihm wird der lobenswerte Versuch unternommen, einen Zusammenhang zwischen Geschlechter- und Naturverhältnissen herzustellen „die in der Umweltsoziologie bislang stark vernachlässigte feministische Diskussion und Geschlechterforschung einzubeziehen und als genderbezogene Perspektive zu etablieren“. (S. 9 Das Buch enthält Beiträge von 15 Autorinnen, die unterschiedliche Natur- und Geschlechtsverhältnisse facettenreich, überwiegend kreativ und theoretisch anspruchsvoll betrachten. Das Buch enthält Zugänge aus der allgemeinen Soziologie, den Sprach- und Kulturwissenschaften, aus politik- und naturwissenschaftlichen Zusammenhängen. Den ausdrücklich formulierten Anspruch, von multi- zu einer inter-disziplinären Durchdringung zu gelangen, erfüllt es nur in Ansätzen (besonders mit der Einleitung und den theoretischen Problemexplikationen. Das zustande gekommene „Nach-, Zusammen- und Querdenken“ über Begriffe, Theorien und neuere Forschungsansätze (von Foucault über Butler bis zu Donna Haraway belegt die Notwendigkeit, die naturwissenschaftlichen Annahmen „immanent zu dekonstruieren“. Sehr aufschlussreich sind in diesem Zusammenhang die Beiträge von Irmgard Schultz, Elvira Scheich, aber auch von Mary Mellor und besonders von Paula-Irene Villa, die interessante und kreative Gedanken zur Klärung des Verhältnisses von Natur, Kultur und Geschlecht anbieten. Deutlich wurde, dass weiterhin ein kontroverses Ringen um angemessene konzeptionelle Fassungen von Geschlechts- und Naturverhältnissen und die Integration von Gender als zentraler analytischer Querschnitts-Kategorie nötig sind. Insgesamt ist dem Buch ist eine schnelle Verbreitung und

Ein Versuch, Naturverhältnisse aus feministischer Sicht zu interpretieren

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Helga Purgand

2002-07-01

Full Text Available Mit dem vorliegenden Sammelband Geschlechterverhältnisse – Naturverhältnisse wird nach dem innovativen Beitrag der feministischen Debatte für umweltsoziologisches Denken gefragt und nach Überschneidungen, Grenzen und Zwischenräumen zwischen „Geschlecht“ und „Natur“ gesucht. In ihm wird der lobenswerte Versuch unternommen, einen Zusammenhang zwischen Geschlechter- und Naturverhältnissen herzustellen „die in der Umweltsoziologie bislang stark vernachlässigte feministische Diskussion und Geschlechterforschung einzubeziehen und als genderbezogene Perspektive zu etablieren“. (S. 9 Das Buch enthält Beiträge von 15 Autorinnen, die unterschiedliche Natur- und Geschlechtsverhältnisse facettenreich, überwiegend kreativ und theoretisch anspruchsvoll betrachten. Das Buch enthält Zugänge aus der allgemeinen Soziologie, den Sprach- und Kulturwissenschaften, aus politik- und naturwissenschaftlichen Zusammenhängen. Den ausdrücklich formulierten Anspruch, von multi- zu einer inter-disziplinären Durchdringung zu gelangen, erfüllt es nur in Ansätzen (besonders mit der Einleitung und den theoretischen Problemexplikationen. Das zustande gekommene „Nach-, Zusammen- und Querdenken“ über Begriffe, Theorien und neuere Forschungsansätze (von Foucault über Butler bis zu Donna Haraway belegt die Notwendigkeit, die naturwissenschaftlichen Annahmen „immanent zu dekonstruieren“. Sehr aufschlussreich sind in diesem Zusammenhang die Beiträge von Irmgard Schultz, Elvira Scheich, aber auch von Mary Mellor und besonders von Paula-Irene Villa, die interessante und kreative Gedanken zur Klärung des Verhältnisses von Natur, Kultur und Geschlecht anbieten. Deutlich wurde, dass weiterhin ein kontroverses Ringen um angemessene konzeptionelle Fassungen von Geschlechts- und Naturverhältnissen und die Integration von Gender als zentraler analytischer Querschnitts-Kategorie nötig sind. Insgesamt ist dem Buch ist eine schnelle Verbreitung und

La actividad poética de Neruda en los años treinta

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Teodosio Femández

2007-12-01

Full Text Available Aunque fue en 1933 cuando Luis Enrique Délano, después compañero de tareas diplomáticas en Madrid y en México, consiguió que la Empresa Letras publicara en Santiago de Chile El hondero entusiasta, no ha de olvidarse que ese libro fue el·efecto ya lejano de la «embriaguez de estrellas, celeste, cósrnica»1 que en 1923, bajo el influjo del poeta uruguayo Carlos Sabat Ercasty, Pablo Neruda sintió en una noche de su Temuco natal. Tras los cinco difíciles años que había vivido como cónsul honorario de su país en distintos lugares del Asia oriental, Neruda había regresado en abril de 1932, y había dedicado sus primeros esfuerzos a preparar la nueva edición de Veinte poemas de amor y una canción desesperada que la Editorial Nascimento publicó en Santiago en junio del mismo año, con la reelaboración de varios poemas, en especial el 2 y el 4, y la sustitución del 9 por otro escrito en aquellas fechas. Antes de llegar ya había completado el volumen que en 1933 constituyó la edición inicial de Residencia en la tierra, también realizada por Nascimento tras los fracasados esfuerzos de Rafael Alberti para que se publicara en España o en Francia, allí con la colaboración de Alejo Carpentier, cuando en París éste dirigía para la argentina Elvira de Alvear la revista Imán, cuyo único número apareció el 1 de abril de 1931.

High-quality two-nucleon potentials up to fifth order of the chiral expansion

Science.gov (United States)

Entem, D. R.; Machleidt, R.; Nosyk, Y.

2017-08-01

We present NN potentials through five orders of chiral effective field theory ranging from leading order (LO) to next-to-next-to-next-to-next-to-leading order (N4LO ). The construction may be perceived as consistent in the sense that the same power counting scheme as well as the same cutoff procedures are applied in all orders. Moreover, the long-range parts of these potentials are fixed by the very accurate π N low-energy constants (LECs) as determined in the Roy-Steiner equations analysis by Hoferichter, Ruiz de Elvira, and coworkers. In fact, the uncertainties of these LECs are so small that a variation within the errors leads to effects that are essentially negligible, reducing the error budget of predictions considerably. The NN potentials are fit to the world NN data below the pion-production threshold of the year 2016. The potential of the highest order (N4LO ) reproduces the world NN data with the outstanding χ2/datum of 1.15, which is the highest precision ever accomplished for any chiral NN potential to date. The NN potentials presented may serve as a solid basis for systematic ab initio calculations of nuclear structure and reactions that allow for a comprehensive error analysis. In particular, the consistent order by order development of the potentials will make possible a reliable determination of the truncation error at each order. Our family of potentials is nonlocal and, generally, of soft character. This feature is reflected in the fact that the predictions for the triton binding energy (from two-body forces only) converges to about 8.1 MeV at the highest orders. This leaves room for three-nucleon-force contributions of moderate size.

Consistent, high-quality two-nucleon potentials up to fifth order of the chiral expansion

Science.gov (United States)

Machleidt, R.

2018-02-01

We present N N potentials through five orders of chiral effective field theory ranging from leading order (LO) to next-to-next-to-next-to-next-to-leading order (N4LO). The construction may be perceived as consistent in the sense that the same power counting scheme as well as the same cutoff procedures are applied in all orders. Moreover, the long-range parts of these potentials are fixed by the very accurate πN low-energy constants (LECs) as determined in the Roy-Steiner equations analysis by Hoferichter, Ruiz de Elvira and coworkers. In fact, the uncertainties of these LECs are so small that a variation within the errors leads to effects that are essentially negligible, reducing the error budget of predictions considerably. The N N potentials are fit to the world N N data below pion-production threshold of the year of 2016. The potential of the highest order (N4LO) reproduces the world N N data with the outstanding χ 2/datum of 1.15, which is the highest precision ever accomplished for any chiral N N potential to date. The N N potentials presented may serve as a solid basis for systematic ab initio calculations of nuclear structure and reactions that allow for a comprehensive error analysis. In particular, the consistent order by order development of the potentials will make possible a reliable determination of the truncation error at each order. Our family of potentials is non-local and, generally, of soft character. This feature is reflected in the fact that the predictions for the triton binding energy (from two-body forces only) converges to about 8.1 MeV at the highest orders. This leaves room for three-nucleon-force contributions of moderate size.

Laxative-induced rhabdomyolysis

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Alfonso Merante

2010-03-01

Full Text Available Alfonso Merante1, Pietro Gareri2,3, Norma Maria Marigliano2, Salvatore De Fazio2, Elvira Bonacci1, Carlo Torchia1, Gaetano Russo1, Pasquale Lacroce1, Roberto Lacava3, Alberto Castagna3, Giovambattista De Sarro2, Giovanni Ruotolo11Geriatrist, Geriatric Unit “Pugliese-Ciaccio” Hospital, Catanzaro, Italy; 2Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University Magna Graecia of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini University Hospital, Catanzaro, Italy; 3Geriatrist, Operative Unit Elderly Health Care, Catanzaro, ItalyAbstract: The present study describes a case of laxative-induced rhabdomyolysis in an elderly patient. An 87-year-old woman was hospitalized for the onset of confusion, tremors, an inability to walk, and a fever that she had been experiencing for 36 hours. She often took high dosages of lactulose and sorbitol syrup as a laxative (about 70 g/day. During her physical examination, the patient was confused, drowsy, and she presented hyposthenia in her upper and lower limbs, symmetric and diffuse moderate hyporeflexia, and her temperature was 37.8°C. Laboratory tests revealed severe hyponatremia with hypokalemia, hypocalcemia, hypochloremia, and metabolic alkalosis. Moreover, rhabdomyolysis markers were found. The correction of hydroelectrolytic imbalances with saline, potassium and sodium chlorure, calcium gluconate was the first treatment. During her hospitalization the patient presented acute delirium, treated with haloperidol and prometazine chloridrate intramuscularly. She was discharged 12 days later, after resolution of symptoms, and normalized laboratory tests. Over-the-counter drugs such as laxatives are usually not considered dangerous; on the other hand, they may cause serum electrolytic imbalance and rhabdomyolysis. A careful monitoring of all the drugs taken by the elderly is one of the most important duties of a physician since drug interactions and

Case series of feasibility considerations that impact operational delivery strategy in the highly competitive rheumatoid arthritis space in Asia

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Wai K

2013-02-01

Full Text Available Karen Wai,1 Lisa Marie Saldanha,1 Elvira Zenaida Lansang,1 Saumya Nayak,1 Anish Sule,2 Ken J Lee31Feasibility and Site Identification Asia, Quintiles East Asia Pte Ltd, Singapore; 2Feasibility and Site Identification India, Quintiles India, Mumbai, India; 3Site Services Asia, Quintiles East Asia Pte Ltd, SingaporeAbstract: The rheumatoid arthritis (RA clinical trial space is very competitive, and recruiting and retaining subjects is of critical importance. Feasibility studies are a central component of ensuring successful recruitment and retention. A feasibility study is an assessment of the practicality of a proposed study protocol, with the goal of understanding challenges and providing risk mitigation strategies leading to better subject enrolment and study start-up should the assessment be favorable. This paper presents findings from a retrospective case series of RA feasibilities, describing important parameters to consider in the highly competitive RA space in Asia. Key parameters identified and discussed are how decisions on clinical development strategy necessitate changes in the clinical operational delivery strategy, with focus on changes in inclusion and exclusion criteria and patient contribution load; how small the patient population becomes when the clinical trial needs to target the patient population that is refractory to standard therapy; regulatory timelines; and the competitive clinical trial landscape. Feasibility assessments are a snapshot in time exercise. Multiple parameters change over time, and, particularly in a space that has become competitive for subjects, one cannot rely on one static feasibility assessment to predict trial performance accurately. Continuous feasibility assessment will also provide insight into the resourcing needs on the part of the sponsor, contract research organization, and investigative site.Keywords: site selection, country selection, clinical operations, risk management, recruitment rates

Savings associated with high-dose hypoallergenic house dust mite immunotherapy in rhinitis and/or asthma patients in Spain

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García Robaina JC

2016-06-01

Full Text Available José Carlos García Robaina,1 Carlos Polanco Sánchez,2 Elvira Estella Pérez,2 1Allergy Department, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, 2Health Economics & Outcomes Research, Corporate Affairs, Merck S.L., Madrid, Spain Objectives: To quantify the cost difference between conventional symptomatic treatment of mite allergy and specific subcutaneous immunotherapy (SCIT. Methods: Observational, retrospective, and multicenter study was carried out in Spain in 2013. The medical records of 419 patients diagnosed with rhinitis and/or bronchial asthma for mite allergy were retrieved. Mean age was 24.9 years (standard deviation 14.4. The use of symptomatic medication (rescue and daily, diagnostic tests, unscheduled medical care, and sick leave days associated with SCIT treatment versus no-SCIT treatment was compared. Also measured was the SCIT treatment to no-SCIT treatment costs ratio: used resources (symptomatic medication, unscheduled medical care, diagnostic tests, and 3 years SCIT treatment and sick leave days were quantified in euros. Efficacy (decreased resource usage of first-year treatment was assumed during the remaining 2 years and also during the 3-year follow-up period. Results: After a single year of SCIT, all quantified resources diminished significantly (P<0.05 from baseline. Estimated reduction in cost items included hospital resources (100% in hospitalizations, 82% in visits to the allergist, and 79% in emergency room visits, therapies (56% in rescue medication and 63% in daily medication, diagnostic tests (77%, and sick leave days (94%. Ratio of comparative calculation described as SCIT treatment versus non-SCIT treatment (or conventional symptomatic treatment is 0.8. Conclusion: Direct costs are reduced by 64% and indirect costs by 94%. SCIT of hypoallergenic preparation of dust mite (Acaroid® allows cost savings versus conventional treatment. Estimated savings for the public National Health

Key feasibility considerations when conducting vaccine clinical trials in Asia–Pacific countries

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Lansang EZ

2013-03-01

Full Text Available Elvira Zenaida Lansang,1 Kenneth Tan,2 Saumya Nayak,1 Ken J Lee,1 Karen Wai1 1Feasibility and Site Identification – Asia, Quintiles East Asia Pte Ltd, Singapore; 2National University of Singapore, Singapore Introduction: Conducting clinical trial feasibility is an important first step in initiating a clinical trial. A robust feasibility process ensures that a realistic capability assessment is made before conducting a trial. A retrospective analysis of vaccine clinical trials was performed to understand changes which could affect feasibility recommendations. Methods: Feasibilities conducted by Quintiles between January 2011 and August 2012 were reviewed. Vaccine studies only involving Asia–Pacific countries were selected, and common study parameters were identified. Information from Quintiles’ database was retrieved to examine changes in parameters over time. Results: A total of six vaccine studies were identified within the 1.7-year period. Two studies were excluded because they did not contain feasibility information or had involved sites that were sponsor selected. Four studies were analyzed. Three cases required healthy volunteers, while one case involved a specific patient population. Age requirement and seasonality of disease mainly influenced recommendations for Study 1. Sponsor’s marketing strategy influenced the recommendations for Study 2. Study 3 showed the effect of a country’s immunization program and reimbursement of vaccines on a study’s success. In contrast to the other studies, Study 4 demonstrated the impact of eligibility criteria in recruitment recommendations for a vaccine trial requiring specific patient pools. Conclusion: Feasibility recommendations for vaccine trials are largely based on (1 eligibility criteria; (2 cultural beliefs; (3 country’s past recruitment performance; (4 use of advertising; (5 site’s access to subject populations; (6 cooperation with local health professionals and government; (7

Functional constipation in children: challenges and solutions

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Levy EI

2017-03-01

Full Text Available Elvira Ingrid Levy,* Roel Lemmens,* Yvan Vandenplas, Thierry Devreker Kidz Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium *These authors contributed equally to this work Abstract: This review intends to update what is known about and what is still a challenge in functional constipation (FC in children regarding epidemiology, pathophysiology, diagnosis, and management. Although FC is a common childhood problem, its global burden remains unknown as data from parts of the world are missing. Another problem is that there is a large variation in prevalence due to differences in study methods and defining age groups. The pathophysiology of FC remains unclear to date but is probably multifactorial. Withholding behavior is likely to be the most important factor in toddlers and young children. Genetics may also play a role since many patients have positive family history, but mutations in genes associated with FC have not been found. Over the past years, different diagnostic criteria for FC in infants and children have been proposed. This year, Rome IV criteria have been released. Compared to Rome III, it eliminates two diagnostic criteria in children under the age of 4 who still wear diapers. Physical examination and taking a thorough medical history are recommended, but other investigations such as abdominal radiography, transabdominal recto-ultrasonography, colonic transit time, rectal biopsies, and colon manometry are not routinely recommended. Regarding treatment, guidelines recommend disimpaction and maintenance therapy with polyethylene glycol (PEG with or without electrolytes. But experience shows that acceptability, adherence, and tolerance to PEG are still a challenge. Counseling of parents and children about causes of FC is often neglected. Recent studies suggest that behavior therapy added to laxative therapy improves the relief of symptoms. Further homogeneous studies, better-defined outcomes, and studies

PREFACE: International Symposium on Ultrasound in the Control of Industrial Processes (UCIP 2012)

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Segura, Luis Elvira; Resa López, Pablo; Salazar, Jordi; Benedito Fort, José Javier; Martínez Graullera, Óscar

2012-12-01

Multiple Scattering of Generic Waves in Particulate Composites' by Félix Alba Consulting. A total of 93 delegates from 21 countries participated actively in this event, and more than ten companies were involved through oral communications, tutorials, exhibition or sponsorship. Conference photograph Conference photograph Organizers Organizers SCIENTIFIC COMMITTEE Dr Luis Elvira, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Pablo Resa, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Oscar F Martinez-Graullera Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Jordi Salazar Department of Electronic Engineering Universitat Politècnica de Catalunya, Spain Dr Jose Benedito Universitat Politècnica de València, Spain ORGANIZING COMMITTEE Dr Luis Elvira, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Prof Malcolm J W Povey, Procter Department of Food Science University of Leeds, United Kingdom Dr Jordi Salazar, Department of Electronic Engineering Universitat Politècnica de Catalunya, Spain Dr Jose Benedito, Universitat Politècnica de València, Spain Dr Oscar F Martinez-Graullera, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Carmen Duran, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Pablo Resa, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dra Cristina Aparicio, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Prof Francisco Montero de Espinosa, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Jaime Rodríguez-López, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Carlos Sierra, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Shiva Kant Shukla, Centro de Acústica Aplicada y

Macroscopical morphology of deterioration of the stone used in the cathedral whole of Granada/Spain

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Alcalde, M.

1992-06-01

Full Text Available The main factors of deterioration that affect the Cathedral Whole of Granada are one of natural thermic origin due to the low temperatures during the winters and the higher thermic oscillations and those of anthropogenical origin: fundamentally the oxidation of metallic elements and atmospheric pollution due to burnt products. For this reason, the more important deterioration mechanisms are the freezing ones due to the expansion produced in the water retained inside the pores and microcracks, fundamentally in the architectonic elements with high expositional surface and in their shady orientation; the main indicators produced are fissuring and spalling. In this way, a lot of elements of Santa Pudia stone located in the Royal Chapel crenellations have disappeared and the rest are very deteriorated. The more compact Sierra Elvira stone used on the upper zone of the cornices has also been affected by the freezing mechanism, which starts with the microcracks produced by differential dilatations due to the thermic oscillations which made the water access easy. The iron corrosion and later expansion of the oxidation products has provoked the cracking and fissuring of many ornamental elements like balls, pinnacles, etc, and this situation has obliged their dismantling on the upper zones due to the danger to the public. The mechanisms of dissolution, crystallization cycles and Chemical action have led to abundant material loosening in the form of grain disgregations overcoats on the higher humidity zones, and formation of hollows (pitting, alveolar erosion, striations in the zones more exposed to the winds. This situation is generalized in the lower zones of the monument, except on the main facade, and in the parapets and lower zones of the cornices. The grain disgregations are more important when biological crusts or unburned deposits exist, the latter being of major abundance on the surfaces near the Gran Vía and in its orientation. It is necessary

Compatibilidad entre nueve cepas de Biomphalaria glabrata de áreas endémicas y no endémicas y una cepa de Schistosoma mansoni venezolanas

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Pino Luz A.

1999-01-01

Full Text Available Se infectaron experimentalmente 9 lotes de 32 caracoles B. glabrata (de 5 a 7mm de diámetro con miracidios de la cepa C5 de Schistosoma mansoni a razón de 5 miracidios por caracol, pertenecientes a las siguientes cepas: En el área endémica de transmisión de Esquistosomiasis mansoni a Sector Puerta Negra, Lago Valencia, b Cagua c Ingenio Bolívar (Estado Aragua d Mariara e Caserío El 25 f Güigüe (Estado Carabobo. Fuera del área endémica de transmisión g Anzoátegui (Estado Lara, h Chabasquén (Estado Portuguesa, i Sector La Elvira, Caripe (Estado Monagas. El período prepatente intramolusco, osciló entre 23 y 25 días, para las 9 cepas evaluadas. La duración total de la infección fue muy variable desde 20 días para la cepa Chabasquén, hasta 93 días para la de Güigüe.La producción total promedio de cercarias al tercer día de iniciada la emisión varió desde X = 74,4 para la cepa de Mariara, hasta X = 591,7 para la cepa de Chabasquén. Se evidenció la existencia de diferencias estadísticamente significativas (H = 97,4, P < 0,05 en la producción total de cercarias al tercer día de iniciada la emisión, detectándose diferencias estadísticamente significativas para casi todas las 36 combinaciones, excepto para las cuatro siguientes: Mariara/Ingenio Bolívar, Cagua/Caserío El 25, Lago de Valencia/Güigüe y Güigüe/Caripe.En lo que respecta al porcentaje de caracoles que presentaron cura espontánea, los valores mas elevados se obtuvieron en las cepas del Lago de Valencia (88,8%, Cagua (85,2%, Chabasquén (82,6%, Caripe (82,6% y Anzoátegui (80%. Mientras que el porcentaje mas bajo se obtuvo para la cepa de Güigüe (21,4%.

"Are cognitive interventions effective in Alzheimer's disease? A controlled meta- analysis of the effects of bias": Correction to Oltra-Cucarella et al. (2016).

Science.gov (United States)

2016-07-01

Reports an error in "Are Cognitive Interventions Effective in Alzheimer's Disease? A Controlled Meta-Analysis of the Effects of Bias" by Javier Oltra-Cucarella, Rubén Pérez-Elvira, Raul Espert and Anita Sohn McCormick (Neuropsychology, Advanced Online Publication, Apr 7, 2016, np). In the article the first sentence of the third paragraph of the Source of bias subsection in the Statistical Analysis subsection of the Correlational Meta-Analysis section should read "For the control condition bias, three comparison groups were differentiated: (a) a structured cognitive intervention, (b) a placebo control condition, and (c) a pharma control condition without cognitive intervention or no treatment at all." (The following abstract of the original article appeared in record 2016-16656-001.) There is limited evidence about the efficacy of cognitive interventions for Alzheimer's disease (AD). However, aside from the methodological quality of the studies analyzed, the methodology used in previous meta-analyses is itself a risk of bias as different types of effect sizes (ESs) were calculated and combined. This study aimed at examining the results of nonpharmacological interventions for AD with an adequate control of statistical methods and to demonstrate a different approach to meta-analysis. ESs were calculated with the independent groups pre/post design. Average ESs for separate outcomes were calculated and moderator analyses were performed so as to offer an overview of the effects of bias. Eighty-seven outcomes from 19 studies (n = 812) were meta-analyzed. ESs were small on average for cognitive and functional outcomes after intervention. Moderator analyses showed no effect of control of bias, although ESs were different from zero only in some circumstances (e.g., memory outcomes in randomized studies). Cognitive interventions showed no more efficacy than placebo interventions, and functional ESs were consistently low across conditions. cognitive interventions delivered

Wind energy resource assessment in Madrid region

Energy Technology Data Exchange (ETDEWEB)

Migoya, Emilio; Crespo, Antonio; Jimenez, Angel; Garcia, Javier; Manuel, Fernando [Laboratorio de Mecanica de Fluidos, Departamento de Ingenieria Energetica y Fluidomecanica, Escuela Tecnica Superior Ingenieros Industriales (ETSII), Universidad Politecnica de Madrid (UPM), C/Jose Gutierrez Abascal, 2-28006, Madrid (Spain)

2007-07-15

The Comunidad Autonoma de Madrid (Autonomous Community of Madrid, in the following Madrid Region), is a region located at the geographical centre of the Iberian Peninsula. Its area is 8.028 km{sup 2}, and its population about five million people. The Department of Economy and Technological Innovation of the Madrid Region, together with some organizations dealing on energy saving and other research institutions have elaborated an Energy Plan for the 2004-12 period. As a part of this work, the Fluid Mechanics Laboratory of the Superior Technical School of Industrial Engineers of the Polytechnic University of Madrid has carried out the assessment of the wind energy resources [Crespo A, Migoya E, Gomez Elvira R. La energia eolica en Madrid. Potencialidad y prospectiva. Plan energetico de la Comunidad de Madrid, 2004-2012. Madrid: Comunidad Autonoma de Madrid; 2004]; using for this task the WAsP program (Wind Atlas Analysis and Application Program), and the own codes, UPMORO (code to study orography effects) and UPMPARK (code to study wake effects in wind parks). Different kinds of data have been collected about climate, topography, roughness of the land, environmentally protected areas, town and village distribution, population density, main facilities and electric power supply. The Spanish National Meteorological Institute has nine wind measurement stations in the region, but only four of them have good and reliable temporary wind data, with time measurement periods that are long enough to provide representative correlations among stations. The Observed Wind Climates of the valid meteorological stations have been made. The Wind Atlas and the resource grid have been calculated, especially in the high wind resource areas, selecting appropriate measurements stations and using criteria based on proximity, similarity and ruggedness index. Some areas cannot be used as a wind energy resource mainly because they have environmental regulation or, in some cases, are very close

Evaluation of the relationship between the pelvic floor muscles and insulin resistance

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Micussi MT

2015-08-01

Full Text Available Maria Thereza Micussi,1 Rodrigo Pegado Freitas,1 Priscylla Helouyse Angelo,2 Elvira Maria Soares,3 Telma Maria Lemos,4 Técia Maria Maranhão51Physical Therapy Department, 2Postgraduate Program in Physical Therapy, 3Januário Cicco Maternity School, 4Clinical Analysis Department, 5Tocogynecology Department, Federal University of Rio Grande do Norte (UFRN, Natal, Rio Grande do Norte, BrazilPurpose: The aim of this study was to evaluate the pelvic floor muscles (PFMs in women with insulin resistance (IR using surface electromyography and to associate the results with insulin levels.Patients and methods: Through an analytical, cross-sectional study, 86 women were evaluated and divided into two groups: a control group (n=35 and an IR group (n=51. Data were collected through detailed history-taking, physical examination, and biochemical analysis. Fasting insulin levels were used for diagnosing IR. Electromyography of the PFMs was used for analyzing the tone and maximal voluntary contraction (MVC. The measures of central tendency and linear regression models were used.Results: The average age was 25.3±4.5 years in the IR group and 27.2±4.4 years in the control group. The mean weight was 75.6±17.6 kg and 51.8±4.9 kg in the IR and control groups, respectively. Fasting insulin levels were 19.7±6.6 µIU/mL in the IR group and 5.4±1.8 µIU/mL in the control group (P<0.010. There were significant differences between the groups with regard to PFM tone (IR: 13.4±3.4 µV; control: 25.1±3.3 µV; P<0.001 and MVC (IR: 47.6±4.5 µV; control: 64.3±5.0 µV; P<0.001. Multiple linear regression analysis using the insulin levels as dependent variable showed a significant association for MVC (P=0.047, weight (P=0.017, and waist circumference (P=0.000.Conclusion: Compared with the control group, the IR group showed lower electromyographic activity of the PFMs, and there was an association between insulin levels and electromyographic activity.Keywords: tone

La personalidad de José Asunción Silva. (II parte

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José Francisco Socarrás

1988-08-01

Full Text Available

Silva y el psicoanalisis

Dos psicoanalistas se han ocupado de Silva. Roberto De Zubiria Consuegra y Mauro Torres. El primero sostiene que el poeta vivió bajo la maldición de un complejo de Edipo manifiesto, transferido hacia su hermana Elvira. El segundo estima que nuestro personaje se estancó en la etapa narcisista del desarrollo y escribe: “El narciso primario no va más allá de los límites de la auto contemplación; vive dentro del principio del placer, reñido con la realidad…”. “El narciso secundario puede combinar, en un equilibrio más o menos precario, la auto contemplación con la comunicación verdadera con los demás”. “Silva no podía amar sexualmente a su hermana. El narciso que había en él se oponía definitivamente a dar el formidable paso de Edipo”. “A lo sumo Silva si amó en su hermana, pero con un amor contemplativo de Narciso, que se siente nítidamente reflejado en el tranquilo rostro de aquella. Elvira es el espejo de Narciso”. Recuérdese la contemplación de que la hacía objeto cuando asistían al Teatro Colón.

Torres analiza De Sobremesa, que considera la expresión del Silva íntimo encarnado en José Fernández, el héroe de la novela, con sus fantasías de vivir la vida plenamente, sueño muy distante de la realidad deparada al poeta por un destino de familia. Fernández exclama” Ah! vivir la vida… eso es lo que quiero, sentir todo lo que se puede sentir, saber todo lo que se puede saber, poder todo lo que se puede”. El texto parece tomado al pie de la letra del de Maria Bashkirtsseff transcrito por el propio Silva en su relat044. Pero Torres se queda a mitad del camino. Señala el síntoma, que sintetiza otros muchos, sin llegar a un diagnóstico. Hacerlo implica poner al lector al tanto de los conceptos fundamentales del psicoanálisis. Para ello me valdré de la Enciclopedia del Psicoanálisis dirigida por Luwing Eidelbert45 y de los trabajos de Heinz

Evolution of the clinical trial landscape in Asia Pacific

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Yathindranath S

2014-07-01

Full Text Available Shourav Yathindranath,1 Amar Kureishi,2 Simranjit Singh,3 Spencer Yeow,3 Grace Geng,4 Karen Wai,1 Audrey Ho,1 Elvira Zenaida Lansang,1 Ken J Lee5 1Feasibility and Site Identification Asia, 2Drug Development Asia, 3Strategic Planning Asia, Quintiles East Asia Private Limited, Singapore; 4People’s Republic of China Site Services, Quintiles, Beijing, People’s Republic of China; 5Asia Site Services, Quintiles East Asia Private Limited, Singapore Introduction: Asia Pacific has and continues to be one of the fastest-growing pharmaceutical markets in the world. This growth has a carry-over effect of driving pharmaceutical research and development investment in the region. Coupled with this, there have been multiple initiatives conducted by governments and other research focused organizations and societies in the region to help support this growth in research. In this report, we discuss the latest developments in pharmaceutical research and development in Asia Pacific and how these various initiatives have made an impact. Methods: An extensive search of the major clinical trial registries, along with the literature and Internet review of the recent developments in clinical trials, was performed comparing two time periods – 2009–2010 and 2011–2012. Results: In overall numbers, the clinical trial industry in Asia Pacific has remained stable when comparing the two time periods, with stable volumes of clinical trial numbers and site numbers. However, on closer inspection, a dynamic change in geography, nature, and therapeutic areas of the trials being conducted is observed. Japan, South Korea, People’s Republic of China, and Taiwan continue to be major clinical trial destinations. Developing countries, such as Indonesia, Vietnam, and Philippines, have seen rising standards of living and medical care; this is starting to impact their contribution to trials. Also, there are an increasing number of local trials in Asia Pacific with a bigger role

The UV Sensor Onboard the Mars Science Laboratory Mission: Correction and Generation of UV Fluxes

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Vicente-Retortillo, Á.; Martinez, G.; Renno, N. O.; Lemmon, M. T.; Gomez-Elvira, J.

2017-12-01

The Rover Environmental Monitoring Station UV sensor (UVS) onboard the Mars Science Laboratory mission has completed more than 1750 sols of measurements, providing an unprecedented coverage ranging from diurnal to interannual times scales [1,2]. The UVS is comprised of six photodiodes to measure the UV flux in the ranges 200-380, 320-380, 280-320, 200-280, 230-290 and 300-350 nm [3]. UV fluxes in units of W/m2 can be found in the NASA Planetary Data System (PDS). However, dust deposition on the UVS and a non-physical discontinuity in the calibration functions when the solar zenith angle is above 30º cause errors in these fluxes that increase with time. We have developed a technique to correct UV fluxes from the effects of dust degradation and inconsistencies in the angular response of the UVS. The photodiode output currents (available in the PDS as lower-level TELRDR products), ancillary data records (available in the PDS as ADR products) and dust opacity values derived from Mastcam observations are used for performing the corrections. The corrections have been applied to the UVA band (320-380 nm) for the first 1000 sols of the mission, providing excellent results [4]. We plan to correct the UV fluxes on each of the six UVS bands and to make these results available in the PDS. Data products generated by this study will allow comparisons of the UV radiation environment at Gale crater with that at the locations of the future missions ExoMars 2020 and Mars 2020, as well as the assessment of the potential survivability of biological contaminants brought to Mars from Earth. References: [1] Smith, M. D., et al. (2016), Aerosol optical depth as observed by the Mars Science Laboratory REMS UV photodiodes, Icarus, 280, 234-248. [2] Vicente-Retortillo, Á., et al. (2017), Determination of dust aerosol particle size at Gale Crater using REMS UVS and Mastcam measurements, Geophys. Res. Lett., 44, 3502-3508. [3] Gómez-Elvira, J., et al. (2012), REMS: The environmental sensor

Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men

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Costa A

2015-06-01

Full Text Available Adilson Costa,1,2 Elisangela Samartin Pegas Pereira,1 Elvira Cancio Assumpção,1 Felipe Borba Calixto dos Santos,1 Fernanda Sayuri Ota,1 Margareth de Oliveira Pereira,1 Maria Carolina Fidelis,1 Raquel Fávaro,1 Stephanie Selma Barros Langen,1 Lúcia Helena Favaro de Arruda,1 Eva Nydal Abildgaard3 1Department of Dermatology, Pontifícia Universidade Católica de Campinas, Campinas, São Paulo, Brazil; 2KOLderma Clinical Trials Institute, Campinas, São Paulo, Brazil; 3Pfizer Consumer Healthcare, Nutritional Sciences, Copenhagen, Denmark Background: Skin aging is a natural process that may be aggravated by environmental factors. Topical products are the conventional means to combat aging; however, the use of oral supplements is on the rise to assist in the management of aged skin.Objective: The purpose of this study was to assess the effects and safety of an oral supplement containing (per tablet marine protein (105 mg, vitamin C (27 mg, grape seed extract (13.75 mg, zinc (2 mg, and tomato extract (14.38 mg in the improvement of skin aging in men.Methods: This single-center, open-label, quasi-experimental clinical study enrolled 47 male subjects, aged 30–45 years, with phototypes I–IV on the Fitzpatrick scale. Subjects received two tablets of the oral supplement for 180 consecutive days. Each subject served as their own control. Clinical assessments were made by medical personnel and by the subjects, respectively. Objective assessments were carried out through pH measurements, sebumetry, corneometry, ultrasound scanning, skin biopsies, and photographic images.Results: Forty-one subjects (87% completed the study. Clinical improvements on both investigator- and subject-rated outcomes were found for the following parameters: erythema, hydration, radiance, and overall appearance (P<0.05. The objective measurements in the facial skin showed significant improvements from baseline in skin hydration (P<0.05, dermal ultrasound density (P<0.001, and

Urraque, Elvire et Sancie. Le rôle et la place des infantes dans l’historiographie castillane (XIIIe-XIVe siècles

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Patricia ROCHWERT-ZUILI

2008-05-01

Full Text Available Dans la « Quatrième partie » de l’Histoire d’Espagne (1270, on ne trouve nulle évocation du statut intermédiaire qu’avaient pu avoir, jusqu’au XIIe siècle, ces seigneures d’infantat, vouées à la chasteté et au célibat mais non recluses, ce qui leur permettait de participer pleinement à la vie politique du royaume. À travers l’image d’Urraque, d’Elvire et de Sancie, on perçoit surtout le rôle que jouèrent les femmes auprès d’Alphonse X et de ses successeurs. La Chronique de vingt rois (1282-1284 semble témoigner du soutien que le roi Sage avait pu trouver auprès de ses filles à la fin de son règne. Profondément influencées par la reine et régente Marie de Molina, la Version sancienne (1289 et la Chronique de Castille (1295-1312 laissent entrevoir les orientations du programme politique « molinien ». Ainsi, dans l’historiographie castillane du tournant des XIIIe et XIVe siècles, l’infante Urraque prend les traits d’une parfaite femme régnante façonnée à l’image de Marie de Molina.La « Cuarta parte » de la Estoria de España (1270 no guarda testimonio del estatuto intermediario que tuvieron, hasta el siglo XII, esas infantas castas y solteras pero no recluidas, lo que les permitía dedicarse plenamente a la vida política del reino. A través de Urraca, Elvira y Sancha se percibe más bien el papel que tuvieron las mujeres al lado de Alfonso X y sus sucesores. La Crónica de veinte reyes (1282-1284 parece rendir homenaje a las hijas del rey Sabio que lo acompañaron hasta el final de su reinado. En la Versión sanciana (1289 y la Crónica de Castilla (1295-1312, en las que influye el modelo de la reina y regente María de Molina, se destacan las orientaciones políticas del « molinismo ». De hecho, en la historiografía castellana de finales del XIII principios del XIV, la infanta Urraca tiene las características de una mujer reinante modélica inspirada en María de Molina.

Environmental DNA for freshwater fish monitoring: insights for conservation within a protected area.

Science.gov (United States)

Fernandez, Sara; Sandin, Miguel M; Beaulieu, Paul G; Clusa, Laura; Martinez, Jose L; Ardura, Alba; García-Vázquez, Eva

2018-01-01

Many fish species have been introduced in wild ecosystems around the world to provide food or leisure, deliberately or from farm escapes. Some of those introductions have had large ecological effects. The north American native rainbow trout ( Oncorhynchus mykiss Walbaum, 1792) is one of the most widely farmed fish species in the world. It was first introduced in Spain in the late 19th century for sport fishing (Elvira 1995) and nowadays is used there for both fishing and aquaculture. On the other hand, the European native brown trout ( Salmo trutta L.) is catalogued as vulnerable in Spain. Detecting native and invasive fish populations in ecosystem monitoring is crucial, but it may be difficult from conventional sampling methods such as electrofishing. These techniques encompass some mortality, thus are not adequate for some ecosystems as the case of protected areas. Environmental DNA (eDNA) analysis is a sensitive and non-invasive method that can be especially useful for rare and low-density species detection and inventory in water bodies. In this study we employed two eDNA based methods (qPCR and nested PCR-RFLP) to detect salmonid species from mountain streams within a protected area, The Biosphere Reserve and Natural Park of Redes (Upper Nalón Basin, Asturias, Northern Spain), where brown trout is the only native salmonid. We also measured some habitat variables to see how appropriate for salmonids the area is. The sampling area is located upstream impassable dams and contains one rainbow trout fish farm. Employing qPCR methodology, brown trout eDNA was detected in all the nine sampling sites surveyed, while nested PCR-RFLP method failed to detect it in two sampling points. Rainbow trout eDNA was detected with both techniques at all sites in the Nalón River' (n1, n2 and n3). Salmonid habitat units and water quality were high from the area studied. In this study, a high quantity of rainbow trout eDNA was found upstream and downstream of a fish farm located

Environmental DNA for freshwater fish monitoring: insights for conservation within a protected area

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Sara Fernandez

2018-03-01

Full Text Available Background Many fish species have been introduced in wild ecosystems around the world to provide food or leisure, deliberately or from farm escapes. Some of those introductions have had large ecological effects. The north American native rainbow trout (Oncorhynchus mykiss Walbaum, 1792 is one of the most widely farmed fish species in the world. It was first introduced in Spain in the late 19th century for sport fishing (Elvira 1995 and nowadays is used there for both fishing and aquaculture. On the other hand, the European native brown trout (Salmo trutta L. is catalogued as vulnerable in Spain. Detecting native and invasive fish populations in ecosystem monitoring is crucial, but it may be difficult from conventional sampling methods such as electrofishing. These techniques encompass some mortality, thus are not adequate for some ecosystems as the case of protected areas. Environmental DNA (eDNA analysis is a sensitive and non-invasive method that can be especially useful for rare and low-density species detection and inventory in water bodies. Methods In this study we employed two eDNA based methods (qPCR and nested PCR-RFLP to detect salmonid species from mountain streams within a protected area, The Biosphere Reserve and Natural Park of Redes (Upper Nalón Basin, Asturias, Northern Spain, where brown trout is the only native salmonid. We also measured some habitat variables to see how appropriate for salmonids the area is. The sampling area is located upstream impassable dams and contains one rainbow trout fish farm. Results Employing qPCR methodology, brown trout eDNA was detected in all the nine sampling sites surveyed, while nested PCR-RFLP method failed to detect it in two sampling points. Rainbow trout eDNA was detected with both techniques at all sites in the Nalón River’ (n1, n2 and n3. Salmonid habitat units and water quality were high from the area studied. Discussion In this study, a high quantity of rainbow trout eDNA was found

Mars Science Laboratory (MSL) - First Results of Pressure Observations

Science.gov (United States)

Harri, Ari-Matti; Kahanpää, Henrik; Kemppinen, Osku; Genzer, Maria; Gómez-Elvira, Javier; Haberle, Robert M.; Schmidt, Walter; Savijärvi, Hannu; Rodríquez-Manfredi, Jose Antonio; Rafkin, Scott; Polkko, Jouni; Richardson, Mark; Newman, Claire; de la Torre Juárez, Manuel; Martín-Torres, Javier; Paz Zorzano-Mier, Maria; Atlaskin, Evgeny; Kauhanen, Janne; Paton, Mark; Haukka, Harri

2013-04-01

planet-wide phenomena and are a key observation for enhancing our understanding of the global atmospheric flows and CO2 cycle of the Martian atmosphere. The surface pressure is rising at this time of the Martian season, and this is clearly seen by the MSL pressure observations. The current surface pressure is slightly over 8 hPa, which represents a rise of a few % since the beginning of the mission. Our Mars Limited Area Model (MLAM) produces similar results to the observations with some deviations. They are currently under investigation. References: [1] Gómez-Elvira J. et al. (2012), Space Sci. Rev. 170, 583-640. [2] Haberle, R.M. et al. (2013) Mars, submitted. [3] Smith, M. et al. (2006), J. Geophys. Res., 111, E12S13.

Mars Science Laboratory (MSL) - First Results of Relative Humidity Observations

Science.gov (United States)

Genzer, Maria; Harri, Ari-Matti; Kemppinen, Osku; Gómez-Elvira, Javier; Renno, Nilton; Savijärvi, Hannu; Schmidt, Walter; Polkko, Jouni; Rodríquez-Manfredi, Jose Antonio; de la Torre Juárez, Manuel; Mischna, Michael; Martín-Torres, Javier; Haukka, Harri; Paz Zorzano-Mier, Maria; Rafkin, Scott; Paton, Mark; MSL Science Team

2013-04-01

final relative humidity results appear to be convincing and are aligned with earlier observations of the total atmospheric precipitable water contents as well as with the modeling results. [3,4,5] References: [1] Gómez-Elvira J. et al. (2012), Space Sci. Rev. 170, 583-640. [2] Mäkinen, T. (2012) Personal communication [3] Haberle, R.M. et al. (2013) Mars, submitted. [4] Smith, M. et al. (2006), J. Geophys. Res., 111, E12S13. [5] Savijarvi et al. (2010), Quart. J. Roy. Meteor. Soc., 136:651, 1497-1505.

Growing risk avoidance in Asian oncology site selection: how trends in site selection are limiting growth of the Asia cancer trial landscape

Directory of Open Access Journals (Sweden)

Horsburgh D

2013-12-01

Full Text Available David Horsburgh,1 Yi-Chen Josey Lee,2 Elvira Zenaida Lansang,1 Ken J Lee,3 Malcolm Ogg,4 Karen Wai1 1Feasibility and Site Identification Asia, Quintiles East Asia Pte Ltd, Singapore; 2Feasibility and Site Identification Asia, Quintiles East Asia Pte Ltd, Taipei, Taiwan; 3Site Services Asia, Quintiles East Asia Pte Ltd, Singapore; 4Global Integrated Site Services, Quintiles, Green Park, Reading, Berkshire, United Kingdom Background: Asia-Pacific represents the fastest-growing region for clinical trials, with growth in oncology studies being a strong contributor. Such demand has seen a rapid change in Asia's total site pool and the number of experienced and inexperienced, or naïve, sites being activated. Given the perceived risks involved with naïve sites, this study aims to investigate changes in the rate of naïve site selection and how this risk management may influence future growth within the region. Methods: Rates of total naïve and experienced sites initiated per year, per protocol, and the relative contribution of each to the yearly site total were analyzed. Data was collected from Quintiles internal metrics as well as from the publicly available ClinicalTrials.gov database and was filtered to include oncology studies involving at least one Asian country, between the years 2000 and 2012. Results and discussion: Despite a general increase in the number of sites activated overall, the contribution of naïve sites to the yearly total fell to 20% in 2012. Experienced sites were heavily favored, with reliance on the existing site network preferred to expansion through naïve sites. This is likely a result of the perceived challenges with using inexperienced sites and the industry desire to avoid this risk. However, fluctuations in naïve sites activation suggest that the limited level of growth in the site pool may not be enough to sustain demand, with sudden outreaches to naïve sites necessary as current site pool capacity is occasionally

Testing and ground calibration of DREAMS-H relative humidity device

Science.gov (United States)

Genzer, Maria; Hieta, Maria; Nikkanen, Timo; Schmidt, Walter; Kemppinen, Osku; Harri, Ari-Matti; Haukka, Harri

2015-04-01

were measured at several temperature points between 0°C and -70°C. Dry baseline was established in vacuum measurements at the Finnish Meteorological Institute. In addition to stable relative humidity points, measurements in changing relative humidity and temperature were done in order to get information about the lag of the sensor. References: 1] Esposito, F. et al: The DREAMS Experiment on the ExoMars 2016 Mission for the Study of Martian Environment during the Dust Storm Season, The Fifth International Workshop on the Mars Atmosphere, 13-16 January 2014, Oxford, UK, 2014. [2] Gómez-Elvira, J. et al.: REMS: The Environmental Sensor Suite for the Mars Science Laboratory Rover, Space Sci. Rev., 170, pp. 583-640, 2012. [3] Harri, A.-M. et al.: Mars Science Laboratory Relative Humidity Observations - Initial Results, JGR Planets, Vol 119 Issue 9, pp. 2132-2147, 2014.

Mode Equivalence of Health Indicators Between Data Collection Modes and Mixed-Mode Survey Designs in Population-Based Health Interview Surveys for Children and Adolescents: Methodological Study.

Science.gov (United States)

Mauz, Elvira; Hoffmann, Robert; Houben, Robin; Krause, Laura; Kamtsiuris, Panagiotis; Gößwald, Antje

2018-03-05

children and adolescents were compared by survey design and data collection mode by calculating predictive margins from regression models. There were no statistically significant differences in sociodemographic characteristics or health indicators between the single-mode control group and any of the mixed-mode survey designs. Differences in sociodemographic characteristics between SAQ-Web and SAQ-paper were found. Web respondents were more likely to be male, have higher levels of education, and higher household income compared with paper respondents. After adjusting for sociodemographic characteristics, only one of the 38 analyzed health indicators showed different prevalence rates between the data collection modes, with a higher prevalence rate for lifetime alcohol consumption among the online-responding adolescents (Pdesign with Web-based and paper questionnaires. ©Elvira Mauz, Robert Hoffmann, Robin Houben, Laura Krause, Panagiotis Kamtsiuris, Antje Gößwald. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 05.03.2018.

Identification, mapping, and analysis of possible evidences of active petroleum systems in the Colorado Basin, offshore Argentina, South America

Science.gov (United States)

Loegering, Markus; Anka, Zahie; Rodriguez, Jorge; Marchal, Denis; di Primio, Rolando; Vallejo, Eduardo; Kohler, Guillermina; Pangaro, Francisco

2010-05-01

analysed in relation to structural and stratigraphic elements present within the syn-rift and post-rift successions. The main observed features consist of seismic vertical pipes where the seismic signal is strongly disturbed. The diameter of mapped seismic pipes ranges from 100 m up to 2000 m. Preliminary classification of these features shows two families of seismic pipes: (1) the first and principal family is mostly concentrated in the centre and innermost part of the basin and seems to be mainly controlled by the stratigraphy, ending in the Elvira Fm (Eocene). Many of these features are linked to the presence of volcanics, as demonstrated by some wells; (2) the second family is located on the oceanward outer part of the basin, reaching the seafloor and resulting in pockmark depressions or seabed mounds. These features represent possible candidates for gas chimneis. Other kinds of gas escape structures as seismic wipe-out zones and hydraulic brecciation are also tentatively observed. The present-day bathymetry from 3D seismic reflection data indicates the presence of seabed pockmarks and submarine channels on the slope of the basin. The circular to near-circular seafloor depressions initially identified on the 2D seismic-reflection profiles correspond to circular-to-elongate pockmarks mapped on the high-resolution bathymetry. Most of the pockmarks present a diameter from 200 m to 900 m and vertical length between 20 m to 100 m, and occur close to submarine channels, which range from 1000 m to 5000 m in width and from 100 m to 500 m in depth. A highly-dense vertically-faulted interval has been identified within the Colorado (Campanian) and Pedro Luro (Paleocene) Formations in the slope region of the basin. These faults correspond to polygonal fault systems that could breach Paleocene/Eocene sealing sequences, allowing fluids to flow vertically or sub-vertically across the seal. Numerical modelling of hydrocarbon generation and migration, calibrated to the observations on

Young and Waltzing Binary Stars

Science.gov (United States)

2001-10-01

stars heat up enough to start nuclear burning. When infant stars in RXJ 0529.4+0041 eventually reach middle-age, their sizes will most likely also be quite similar to that of the Sun. The significance of RXJ 0529.4+0041 Few systems are known for which such precise determinations of the stellar parameters have ever been possible - and this binary system represents the first case where both the components are such young stars . A detailed comparison of the derived stellar parameters with current models for the evolution of young stars shows fairly good agreement for the primary component. However, there are certain discrepancies in the case of the secondary component, showing that the current models for the early stages of lower-mass stars must still be refined. More information Part of the results described in this press release are described in more detail in a scientific article ( "RXJ 0529.4+0041: a low-mass pre-main sequence eclipsing-spectroscopic binary" by E. Covino et al.) that has been published in the European research journal Astronomy & Astrophysics (Vol. 361, p. 49). Notes [1] The team consists of Elvira Covino (Principal Investigator), Juan M. Alcalá , Rosita Paladino (all Osservatorio Astronomico di Capodimonte, Napoli, Italy), Antonio Frasca , Santo Catalano , Ettore Marilli (all Osservatorio Astrofisico di Catania, Italy) and Michael Sterzik (ESO-Chile). [2] One solar mass corresponds to 1.99 10 30 kg, or about 330,000 times the mass of the Earth. The Sun is about 4500 million years old and its total lifetime is of the order of 12-13,000 million years. It is an interesting thought that if the Sun would have been somewhat heavier, its total lifetime might have been too short for living organisms to develop on the Earth. In fact, the biological evolution that ultimately lead to the emergence of human beings apparently lasted about 4 billion years; this corresponds to the total lifetime of a star that is only about 20 % heavier than the Sun. Note also the