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Sample records for aaps

  1. Aminoalkylpyridines (AAPs), triazoline metabolite analogues, as anticonvulsants highly effective in the MES test.

    Science.gov (United States)

    Kadaba, Pankaja K; Dixit, Trupti

    2003-10-01

    Elucidation of the metabolism and pharmacology of 1,2,3-triazolines (TRs) led to the identification of the triazoline pharmacophore and the evolution of the aminoalkylpyridines (AAPs). The AAPs have no activity in the scMet test but are highly effective in the MES seizure test by the oral route. The AAPs bind to the sigma(1) receptor with low affinity, but high selectivity. They impair Glu release to the same extent as the triazolines and afforded a high degree of protection in the kindled rat. They show no affinity for the NMDA/PCP receptor sites; thus the toxic side effects of NMDA antagonists are absent in the sigma selective AAPs. Variations of the heterocyclic unit, the alkyl chain and the amino group in the AAP leads, indicated that the 4-pyridyl substituent along with a methyl (alkyl) group, and a 4-C1, 3-C1 or 3,4-C1(2) substitution on the N-phenyl group, afforded the most active compounds. Amino group modification by acylation did not improve activity. The hydrazone compounds were the most active. Although the AAPs are very effective in the MES and the kindling models of epilepsy, they showed only low to moderate activity in protecting neuronal cells in stroke-induced cerebral ischemia. In the case of the TR compounds, even the least effective TR afforded 47% protection from neuronal injury. It is not known at this point, whether activity in both the MES and scMet tests, which would imply a role for both Glu and GABA, is a prerequisite for antiischemic activity. PMID:12871088

  2. Connecting Source with Sink: The Role of Arabidopsis AAP8 in Phloem Loading of Amino Acids.

    Science.gov (United States)

    Santiago, James P; Tegeder, Mechthild

    2016-05-01

    Allocation of large amounts of nitrogen to developing organs occurs in the phloem and is essential for plant growth and seed development. In Arabidopsis (Arabidopsis thaliana) and many other plant species, amino acids represent the dominant nitrogen transport forms in the phloem, and they are mainly synthesized in photosynthetically active source leaves. Following their synthesis, a broad spectrum of the amino nitrogen is actively loaded into the phloem of leaf minor veins and transported within the phloem sap to sinks such as developing leaves, fruits, or seeds. Controlled regulation of the source-to-sink transport of amino acids has long been postulated; however, the molecular mechanism of amino acid phloem loading was still unknown. In this study, Arabidopsis AMINO ACID PERMEASE8 (AAP8) was shown to be expressed in the source leaf phloem and localized to the plasma membrane, suggesting its function in phloem loading. This was further supported by transport studies with aap8 mutants fed with radiolabeled amino acids and by leaf exudate analyses. In addition, biochemical and molecular analyses revealed alterations in leaf nitrogen pools and metabolism dependent on the developmental stage of the mutants. Decreased amino acid phloem loading and partitioning to sinks led to decreased silique and seed numbers, but seed protein levels were unchanged, demonstrating the importance of AAP8 function for sink development rather than seed quality. Overall, these results show that AAP8 plays an important role in source-to-sink partitioning of nitrogen and that its function affects source leaf physiology and seed yield. PMID:27016446

  3. SELECTIVE EVALUATION OF TWO URINARY ENZYMES (NAG AND AAP BEFORE AND AFTER UNILATERAL SHOCK WAVE LITHOTRIPSY

    Directory of Open Access Journals (Sweden)

    M. R. Nikoobakht

    2006-09-01

    Full Text Available Biological effects extracorporeal shock wave lithotripsy (ESWL is not precisely known. We have evaluated two urinary enzymes activity N-acetyl-B-D-glucosamine (NAG and alanine amino peptidase (AAP before and after unilateral ESWL as markers for renal parenchymal damage. Forty eight patients with kidney stones (mean age 39 who had presented for the first time or at least one year after their previous lithotripsy underwent ESWL. Urinary specimens were collected before and after first, third and seventh days of lithotripsy and NAG, AAP were evaluated. These enzymes displayed the greatest activity 24 hours after ESWL with significant difference compared to the control group, (P < 0.05 versus 0.02. Elevation of urinary enzymes activity correlated with stone size particularly stones larger than 2 cm. These data suggest that there is some tubular and parenchymal damage induced by ESWL that needs time to get improved. The higher urinary enzyme activity in patients with larger stones ( > 2 cm is probably related to injury resulting from passage of smaller stones, produced after lithotripsy of a large stone, and it is suggested that these patients are treated with a safer procedure.

  4. Synergistic Radiation Protective Effect of Purified Auricularia auricular-judae Polysaccharide (AAP IV with Grape Seed Procyanidins

    Directory of Open Access Journals (Sweden)

    Haina Bai

    2014-12-01

    Full Text Available The aim of this study was to investigate the synergistic antioxidant potential and protective effect of grape seed procyanidins (GSP in combination with Auricularia auricular-judae polysaccharides (AAP IV on radiation injury in splenocytes. Rat splenocyte irradiation resulted in significantly higher apoptosis rate, malondialdehyde (MDA (p < 0.005, reactive oxygen species (ROS (p < 0.01; cell viability, total superoxide dismutase (T-SOD (p < 0.01, catalase (CAT (p < 0.01, glutathione peroxidase (GSH-PX (p < 0.05, activity and glutathione (GSH (p < 0.01 levels were significantly reduced, compared with the control group. “GSP + AAP IV” treatment of rat splenocytes at doses of “GSP (0.3 μg/mL + AAP IV (50 μg/mL” displayed higher radioprotective and antioxidative effects than the administration of either GSP or AAP IV, as evident by lower levels of MDA (p < 0.001 concentration, as well as higher cell viability and T-SOD (p < 0.05, CAT (p < 0.005, GSH-PX (p < 0.01 and GSH content compared to the radiation group. In addition, in vivo studies have shown that “GSP + AAP IV” significantly ameliorated the decrease of spleen index (p < 0.005 and spleen GSH (p < 0.005 levels and significantly inhibited the increase of MDA (p < 0.005 levels of spleen with radiation-induced damage, compared with the non-treated group. The in vivo and in vitro results suggested that GSP and AAP IV have a synergistic protective effect against radiation-induced injury by improving the antioxidant and immunomodulation activities.

  5. Construction and analysis of an intergeneric fusion from Pigmentiphaga sp. strain AAP-1 and Pseudomonas sp. CTN-4 for degrading acetamiprid and chlorothalonil.

    Science.gov (United States)

    Wang, Guangli; Zhu, Danfeng; Xiong, Minghua; Zhang, Hui; Liu, Yuan

    2016-07-01

    Pseudomonas sp. CTN-4 degrades chlorothalonil (CTN) but not acetamiprid (AAP), and Pigmentiphaga sp. strain AAP-1 degrades AAP but not CTN. A functional strain, AC, was constructed through protoplast fusion of two parental strains (Pseudomonas sp. CTN-4 and Pigmentiphaga sp. strain AAP-1) in order to simultaneously improve the degradation efficiency of AAP and CTN. Fusant-AC with eight transfers on plates containing two antibiotics and CTN was obtained. For the purpose of identifying and confirming the genetic relationship between fusant-AC and its parents, randomly amplified polymorphic DNA (RAPD), scanning electron microscopy (SEM), and 16S ribosomal DNA (rDNA) analysis were performed. In toto, RAPD fingerprint analysis produced 194 clear bands with 9 primers, which not only had bands in common with strains CTN-4 and AAP-1, but also had its own novel fusant-specific bands. The genetic similarity indices between fusant-AC and parental strains CTN-4 and AAP-1 were 0.40 and 0.69, respectively. The result of SEM indicated that the cell morphology of fusant-AC differed from both its parents. The fusant strain AC possesses a strong capability for AAP and CTN degradation. At AAP concentration (50-300 mg L(-1)), the degradation was achieved within 5 h. At the initial dose of 50 and 100 mg L(-1) CTN, the percentages reached 96 and 91 % over a 36-h incubation period. The present study indicates that the protoplast-fusion technique may have possible applications in environmental pollution control. PMID:27023810

  6. Newborn Male Circumcision with Parental Consent, as Stated in the AAP Circumcision Policy Statement, Is Both Legal and Ethical.

    Science.gov (United States)

    Brady, Michael T

    2016-06-01

    Newborn male circumcision is a minor surgical procedure that has generated significant controversy. Accumulating evidence supports significant health benefits, most notably reductions in urinary tract infections, acquisition of HIV and a number of other sexually transmitted infections, penile cancer, phimosis, paraphimosis, balanitis and lichen sclerosis. While circumcision, like any surgical procedure, has risks for complications, they occur in less than 1 in 500 infants circumcised and most are minor and require minimal intervention. The CDC and the American Academy of Pediatrics (AAP) believe that health benefits of circumcision outweigh the risks. For this reason, the AAP believes that parents should be allowed to make the decision concerning circumcision of their male infants after receiving non-biased information on health risks and health benefits. PMID:27338601

  7. Newborn Male Circumcision with Parental Consent, as Stated in the AAP Circumcision Policy Statement, Is Both Legal and Ethical.

    Science.gov (United States)

    Brady, Michael T

    2016-06-01

    Newborn male circumcision is a minor surgical procedure that has generated significant controversy. Accumulating evidence supports significant health benefits, most notably reductions in urinary tract infections, acquisition of HIV and a number of other sexually transmitted infections, penile cancer, phimosis, paraphimosis, balanitis and lichen sclerosis. While circumcision, like any surgical procedure, has risks for complications, they occur in less than 1 in 500 infants circumcised and most are minor and require minimal intervention. The CDC and the American Academy of Pediatrics (AAP) believe that health benefits of circumcision outweigh the risks. For this reason, the AAP believes that parents should be allowed to make the decision concerning circumcision of their male infants after receiving non-biased information on health risks and health benefits.

  8. Veracity and rhetoric in paediatric medicine: a critique of Svoboda and Van Howe's response to the AAP policy on infant male circumcision.

    Science.gov (United States)

    Morris, Brian J; Tobian, Aaron A R; Hankins, Catherine A; Klausner, Jeffrey D; Banerjee, Joya; Bailis, Stefan A; Moses, Stephen; Wiswell, Thomas E

    2014-07-01

    In a recent issue of the Journal of Medical Ethics,Svoboda and Van Howe commented on the 2012 changein the American Academy of Pediatrics (AAP) policy on newborn male circumcision, in which the AAP stated that benefits of the procedure outweigh the risks. Svoboda and Van Howe disagree with the AAP conclusions. We show here that their arguments against male circumcision are based on a poor understanding of epidemiology,erroneous interpretation of the evidence, selective citation of the literature, statistical manipulation of data, and circular reasoning. In reality, the scientific evidence indicates that male circumcision, especially when performed in the newborn period, is an ethically and medically sound low-risk preventive health procedure conferring a lifetime of benefits to health and well-being.Policies in support of parent-approved elective newborn circumcision should be embraced by the medical,scientific and wider communities.

  9. Distribution of Pathogenic Genes aatA, aap, aggR, among Uropathogenic Escherichia coli (UPEC) and Their Linkage with StbA Gene.

    Science.gov (United States)

    Nazemi, A; Mirinargasi, M; Merikhi, N; Sharifi, S H

    2011-07-01

    Urinary tract infection (UTI) with E. coli (UPEC) is one of the most common bacterial infections among human beings. In addition to the host predisposing factors, genes are also proposed to have an important role in the occurrence of UTIs. This study investigated the distribution of three pathogenic genes including aggR, aap and aatA among UPEC infected samples and their linkage with stbA, the essential gene for maintaining of pAA plasmid. A total of 244 samples were collected from patients with UTIs through clinical laboratories located in western side of Tehran (Iran) during years 2008-2009. E. coli isolation was performed according to standard laboratory methods. DNAs were extracted from samples using Boiling method, and the presence of aap, aggR, aatA and stbA genes were investigated by PCR. No pathogenic genes (aap, aggR, aatA) were found in 104 out of 244 UPEC samples, while 14 of them were carrying stbA gene. Out of 140 UPEC samples with pathogenic genes, 94 (46.6%) were carrying aap gene, 52 (23%) aggR gene, and 80 (35.4%) aatA gene. A total of 18 samples were also carrying all pathogenic genes together. Moreover, 44 out of 144 samples were carrying stbA gene. The results obtained by this study showed that the aggR, aap and aatA pathogenic genes have different existence patterns in different E. coli strains that infect different organs. Our study also showed that these three plasmid genes in EAEC strains are able to transpose in the genome and change their level of linkage with pAA plasmid essential gene stbA. Meanwhile, this study confirmed that aggR, aap and aatA genes are not specific to only EAEC strains.

  10. 2012 AAPS National Biotech Conference Open Forum: a perspective on the current state of immunogenicity prediction and risk management.

    Science.gov (United States)

    Rajadhyaksha, Manoj; Subramanyam, Meena; Rup, Bonnie

    2013-10-01

    The immunogenicity profile of a biotherapeutic is determined by multiple product-, process- or manufacturing-, patient- and treatment-related factors and the bioanalytical methodology used to monitor for immunogenicity. This creates a complex situation that limits direct correlation of individual factors to observed immunogenicity rates. Therefore, mechanistic understanding of how these factors individually or in concert could influence the overall incidence and clinical risk of immunogenicity is crucial to provide the best benefit/risk profile for a given biotherapeutic in a given indication and to inform risk mitigation strategies. Advances in the field of immunogenicity have included development of best practices for monitoring anti-drug antibody development, categorization of risk factors contributing to immunogenicity, development of predictive tools, and development of effective strategies for risk management and mitigation. Thus, the opportunity to ask "where we are now and where we would like to go from here?" was the main driver for organizing an Open Forum on Improving Immunogenicity Risk Prediction and Management, conducted at the 2012 American Association of Pharmaceutical Scientists' (AAPS) National Biotechnology Conference in San Diego. The main objectives of the Forum include the following: to understand the nature of immunogenicity risk factors, to identify analytical tools used and animal models and management strategies needed to improve their predictive value, and finally to identify collaboration opportunities to improve the reliability of risk prediction, mitigation, and management. This meeting report provides the Forum participant's and author's perspectives on the barriers to advancing this field and recommendations for overcoming these barriers through collaborative efforts.

  11. AMC12和AAP1卫星更名加入新天星座

    Institute of Scientific and Technical Information of China (English)

    华宇星

    2007-01-01

    2007年3月5日,SES新天卫星公司宣布,两颗SES系列通信卫星AMC 12(该卫星的33个转发器原提供给SES Astra公司使用,故也命名为Astra 4A)司AAP1已转交该公司运营,这两颗卫星分别重新命名为NSS10和NSS11,其所有用户及相关的容量管理业务现由SES新天卫星公司负责。基于此,现在新天卫星星座由7颗通信卫星组成,完善了全球不同地区间的连通性,以及除欧洲和北美地区之外世界上其它地区的容量分配服务及区域互联。

  12. Detection of a broad range of Leishmania species and determination of parasite load of infected mouse by real-time PCR targeting the arginine permease gene AAP3

    OpenAIRE

    Tellevik, Marit Gjerde; Müller, Karl Erik; Rebbestad, Karen; Nerland, Audun Helge

    2014-01-01

    Leishmaniasis is one of the world's most neglected infectious diseases, affecting around 12 million people and more than 350 million at risk of infection. The clinical picture varies from self-healing cutaneous lesions to severe visceral infections, but still no commercial vaccines for humans are available and the currently used drugs have unpleasant side effects. Here we report a real-time PCR assay targeting the arginine permease gene AAP3 that can be applied for all the nine different spec...

  13. Detection of a broad range of Leishmania species and determination of parasite load of infected mouse by real-time PCR targeting the arginine permease gene AAP3.

    Science.gov (United States)

    Tellevik, Marit Gjerde; Muller, Karl Erik; Løkken, Karen Rebbestad; Nerland, Audun Helge

    2014-09-01

    Leishmaniasis is one of the world's most neglected infectious diseases, affecting around 12 million people and more than 350 million at risk of infection. The clinical picture varies from self-healing cutaneous lesions to severe visceral infections, but still no commercial vaccines for humans are available and the currently used drugs have unpleasant side effects. Here we report a real-time PCR assay targeting the arginine permease gene AAP3 that can be applied for all the nine different species of the Leishmania genus tested; 4 Old World species and 5 New World species, from both L. (Leishmania) and L. (Viannia) subgenera. No cross-reaction was seen with Trypanosoma cruzi, Trypanosoma brucei, human or mouse genomic DNA. The assay has a high sensitivity, with a limit of detection of 10fg DNA for L. (L.) major and L. (L.) donovani, and 100fg DNA for L. (V.) braziliensis, and can be used for both qualitative and quantitative purposes. This AAP3-Assay, run in duplex with a host specific gene-assay, was also successfully used for quantification of parasite load of footpads from L. (L.) major-infected mice. It can therefore be a valuable tool in applications like monitoring effects of drugs, the selection of vaccine candidates and in screening patients, including asymptomatic carriers. PMID:24859532

  14. Cloning and preliminary functional analysis of an amino acid permease gene GmAAP2-like 1 in soybean%大豆氨基酸透性酶基因GmAAP2-like 1的克隆及功能初探

    Institute of Scientific and Technical Information of China (English)

    李美美; 夏铜梅; 王丹; 梅圆圆; 王宁宁

    2016-01-01

    Amino acid permeases play important roles in transferring amino acids between different parts of the plants; however, so far their functions have rarely been studied in soybean. In this research, an amino acid per-mease gene,GmAAP2-like 1, was seen to be up-regulated in primary leaves of hydroponically grown soybean (Glycine max) cultivar ‘Williams 82’ under nitrogen-deficiency treatment compared with nitrogen-sufficient control. The RT-PCR analysis further showed thatGmAAP2-like 1 was much more abundantly in flowers, leaves and stems of soybean while it showed very low expression in roots and seeds. During the cloning pro-cess, it was found that the vector carrying35S:GmAAP2-like 1 could be transformed intoEscherichia colistrain DH5αsuccessfully but was lethal toAgrobacterium tumerfaciens strain GV3101. As an alternative strategy, this gene was then cloned by fusion PCR with an intron inserted after the ifrst extron and the following transforma-tions turned out to be successful in bothE. coli andAgrobacterium strains mentioned above. Subsequently, the obtainedArabidopsis thalianatransgenic lines of35S:GmAAP2-like 1 with intron were veriifed by genomic PCR and semi-quantitative RT-PCR analysis, and the results showed that the intron was cut off correctly and the gene of interest was overexpressed in almost all the lines examined. Furthermore, it was shown that even though the growth of wild-type and transgenic seedlings were both inhibited after toxic glutamate analogues treatment in comparison to that of the mock control, the growth inhibition of transgenic lines was much more signiifcant, implying that GmAAP2-like 1 could possibly transport such acidic amino acid.%氨基酸透性酶(amino acid permeases)在植物不同器官的氨基酸转运过程中发挥着重要作用,但迄今为止,大豆中氨基酸透性酶相关的研究甚少。本文利用大豆初生叶水培系统对大豆(Glycine max)品种‘Williams 82’进行缺氮处理后,发现与

  15. Economic evaluation of carbon adsorption/ion exchange wastewater-treatment options for Sunflower AAP (Army Ammunition Plant) NQ (nitroguanidine) wastewater-treatment facility. Final report, October 1986-July 1987

    Energy Technology Data Exchange (ETDEWEB)

    Balasco, A.A.; Cheng, G.C.; Field, E.L.; Vejins, V.R.

    1987-07-31

    The objective of this subtask was to provide an estimate of the capital investment and operating costs for the wastewater-treatment technology option involving activated-carbon adsorption and ion exchange for primary separation, and multiple-effect evaporation and spray drying for volume reduction. During the course of this study, however, it became evident that the process economics could be significantly improved of the ion-exchange step was eliminated from the process scheme. The bases for the system design, plant operation, and cost evaluation were provided to Arthur D. Little by Sunflower AAP personnel to make certain that direct comparisons could be made with other treatment options under consideration.

  16. Asymmetric transcriptomic signatures between the cob and florets in the maize ear under optimal- and low-nitrogen conditions at silking, and functional characterization of amino acid transporters ZmAAP4 and ZmVAAT3.

    Science.gov (United States)

    Pan, Xiaoying; Hasan, Md Mahmudul; Li, Yanqiang; Liao, Chengsong; Zheng, Hongyan; Liu, Renyi; Li, Xuexian

    2015-10-01

    Coordinated functioning of the cob and florets of the maize ear confers grain yield. The cob is critical for carbon partitioning and assimilated nitrogen (N) supply for grain development. However, molecular recognition of the cob and peripheral florets, characterization of genes mediating translocation of N assimilates, and responses of these two tissues to low N (LN) remain elusive. Transcriptional profiling of the ear of a maize hybrid at silking in the field revealed 1864 differentially expressed genes between the cob and florets, with 1314 genes up-regulated in the cob and 550 genes up-regulated in florets. The cob was characterized by striking enrichment of genes that are involved in carbon/N transport and metabolism, consistent with the physiological role of the cob in carbon/N storage and transfer during ear development. The florets were characterized by enrichment of hormone signalling components and development related genes. We next examined the response of the cob and florets to LN stress. LN caused differential expression of 588 genes in the cob and only 195 genes in the florets, indicating that the cob dominated the response of the ear to LN at the transcriptional level. LN caused comprehensive alterations such as carbon/N metabolism or partitioning, hormone signalling and protein phosphorylation in terms of gene expression in the cob and/or florets. Fourteen genes responsive specifically to LN provided potential molecular markers for N-efficient maize breeding. We further functionally characterized two newly identified broad-spectrum amino acid transporters, ZmAAP4 and ZmVAAT3, that showed distinct expression patterns in the cob and florets and potentially important roles in amino-N mobilization in the ear. While both proteins could transport various amino acids into yeast or Arabidopsis cells, ZmAAP4 appeared to have higher efficiencies than ZmVAAT3 in transporting seven out of 22 examined amino acids. PMID:26136266

  17. The spectral library of the AAPS

    Science.gov (United States)

    Davie, Matthew; Tinney, Chris; Wittenmyer, Robert

    2015-08-01

    The Anglo-Australian Planet Search program has been operating since 1997 and is still collecting high-resolution spectra of more than two hundred solar-like stars. Over forty thousand stellar spectra have been collected through an Iodine cell, and the radial velocity of the target of each spectrum determined.This project aims to reduce and calibrate the spectra and remove the interposed Iodine spectrum in order to recover the original stellar spectrum. The resultant library of spectra, in addition to being made available to the wider astronomical community, will be used to examine stellar activity, and to create high signal-to-noise composite spectra.We present initial results of the reduction process and indicate the quality of composite spectra that may be expected.

  18. DTPA Inhibits Formation of Staphylococcus Epidermidis Biofilm Associated with Prosthetic Joints: Relative Gene (AAP) Expressions%Zn2+螯合剂DTPA(二乙基三胺五乙酸)对人工关节假体感染后表皮葡萄球菌生物膜形成及相关基因表达的影响

    Institute of Scientific and Technical Information of China (English)

    薛俊强; 戚超; 王湘达; 申友亮; 于腾波

    2012-01-01

    Objective:To investigate theinhibitory effect of DTPA on the formation of Staphylococcus epidertnidis biofilm and the expressions of relative genes(AAP).Methods:New Zealand white rabbits were used to establish the animal model of prosthetic joints infection.Rabbits were randomly divided into the experimental group and control group.The bacteria were injected with 0.1ml 1% DTPA into the knee of rabbits in experimental group; The rabbits were injected with bacteria in the control group.Synovial fluid was extracted in the 2,4,6,8 and 16 days.The expressions of AAP were detected by the way of fluorescent quantitation RT-PCR,Scanning electron microscopy and histological observations were dettected.Results:DTPA can significantly inhibit the expression of AAP in Staphylococcus epidermidis.Scanning electron microscopy found on the day of 2,4,6,8,16 the number of bacteria adhere to the prosthetic surface had decreased significantly in experimental group compared with that in the control group.Conclusion:DTPA can inhibit the formation of the biofilm of Staphylococcus epidermidisthrough suppressing the relative genes.%目的:探讨DTPA对人工关节假体(prosthetic joints infection,PJI)感染后表皮葡萄球茵生物膜形成及所需基因聚集相关蛋白(AAP)基因表达的影响.方法:构建新西兰大白兔假体感染表皮葡萄球菌生物膜模型,随机分为实验组(n=25)和对照组(n=25),对照组只注射细茵,实验组在注入细菌的同时,注射DTPA,分别于注射后第2、4、6、8、16天灌洗、收集膝关节液,采用RT-PCR方法检测不同时间点目的基因AAP基因表达的变化.对不同时间点的假体感染动物行膝关节假体扫描电镜和假体周围组织学观察.结果:DTPA可以显著抑制AAP基因的表达,扫描电镜观察第2、4、6、8、16天实验组较对照组假体表面粘附表皮葡萄球茵明显减少(P<0.05),生物膜明显受抑制.实验组假体周围组织炎性反应较对照组明显减轻.

  19. The Possibility of Building Nuclear Power Plant Free from Severe Accident Risk PWR NPP with advanced all passive safety cooling systems (AAP SCS)%发展无严重事故风险核电站的曙光具有完全非能动安全冷却系统的压水堆核电站

    Institute of Scientific and Technical Information of China (English)

    肖宏才

    2013-01-01

    A complete set of advanced all passive safety cooling systems (AAP SCS) for PWR NPP,actuated by natural force has been put forward in the article.Here the natural force mainly means the fore,which created by change of pressure distribution in the first loop of PWR as a result of operational regime conversion from one to another,including occurrence of accident situation.Correspondent safety cooling system will be actuated naturally and then put it into passive operation after occurring some kind of accident,so accidental situation will be mitigated right after it's occurrence and core residual heat will be naturally moved from the active core to the ultimate heat sink.There is no need to rely on automatic control system,any active equipment and human actions in all working process of the AAP SCS,which can reduce the probability of severe accident to zero,so as to exclude the need of evacuation plan around AAP nuclear power plant and eliminate the public's concern and doubt about nuclear power safety.Implementation of the AAP SCS concept is only based on use of evolutionary measures and state-of-the-art technology.So at present time it can be used for design of new-type third generation PWR nuclear power plant without severe accident risk,and for modernization of existing second generation nuclear power plant.%本文提出了用自然力直接触发启动压水堆核电站一整套完全非能动的停堆安全冷却系统.这里的自然力主要是指一回路运行工况转换时由于其压力分布变化所形成的压差力.在这一系统中,当进行停堆或发生某种一回路事故工况时,相应的安全冷却系统便自然地投入运行,立即缓解事故后果,将事故时一回路释放的能量及堆芯余热非能动地排入最终热阱.在全过程中不依靠自动控制系统、能动设备及任何人为因素的介入,即可确保对堆芯余热无限期的安全冷却能力,完全避免压水堆核电站发生向环境泄漏放射性物

  20. What Made Them Successful: An Introspective Survey of AAPS Members

    Directory of Open Access Journals (Sweden)

    Pamela A. Rudnicki, BS

    2015-03-01

    Conclusion: The authors believe that recognizing the relative importance of such factors, and their associated biases, is essential for the process of selecting and developing future successful plastic surgeons.

  1. Introduction: A welcome to the first special animal health issue of AAPS PharmSci

    OpenAIRE

    Martinez, Marilyn; Soback, Stefan

    2002-01-01

    The goal of this special volume is to provide veterinary scientists with state-of-the art reviews in animal health and to inform human health scientists of the various challenges and collaborative opportunities associated with their animal health counterparts. The contributors are highly respected experts, providing invaluable insights into current issues and state-of-the-art advances within veterinary medicine.

  2. USA välispoliitiliste hoiakute muutumine XXI sajandi alguses / Aap Neljas

    Index Scriptorium Estoniae

    Neljas, Aap, 1967-

    2003-01-01

    USA poliitikas on olnud ilmne tendents jagada "rahulikes piirkondades" korrahoidmise koormat teiste suurriikidega ja säilitada vabad käed suuremate kriiside lahendamiseks, kus kaalul on otseselt USA rahvuslikud huvid (nt ligipääs naftale või juhtroll maailmas)

  3. AAPS and US FDA Crystal City VI workshop on bioanalytical method validation for biomarkers.

    Science.gov (United States)

    Lowes, Steve; Ackermann, Bradley L

    2016-02-01

    Crystal City VI Workshop on Bioanalytical Method Validation of Biomarkers, Renaissance Baltimore Harborplace Hotel, Baltimore, MD, USA, 28-29 September 2015 The Crystal City VI workshop was organized by the American Association of Pharmaceutical Scientists in association with the US FDA to continue discussion on the bioanalysis of biomarkers. An outcome of the Crystal City V workshop, convened following release of the draft FDA Guidance for Industry on Bioanalytical Methods Validation in 2013 was the need to have further discussion on biomarker methods. Biomarkers ultimately became the sole focal point for Crystal City VI, a meeting attended by approximately 200 people and composed of industry scientists and regulators from around the world. The meeting format included several panel discussions to maximize the opportunity for dialogue among participants. Following an initial session on the general topic of biomarker assays and intended use, more focused sessions were held on chromatographic (LC-MS) and ligand-binding assays. In addition to participation by the drug development community, significant representation was present from clinical testing laboratories. The experience of this latter group, collectively identified as practitioners of CLIA (Clinical Laboratory Improvement Amendments), helped shape the discussion and takeaways from the meeting. While the need to operate within the framework of the current BMV guidance was clearly acknowledged, a general understanding that biomarker methods validation cannot be adequately depicted by current PK-centric guidelines emerged as a consensus from the meeting. This report is not intended to constitute the official proceedings from Crystal City VI, which is expected to be published in early 2016. PMID:26795584

  4. Aap, Noot, Mustafa...: Het effect van taalafstand en koloniaal verleden op leesprestaties

    NARCIS (Netherlands)

    Kooistra, J.P.; Ultee, W.C.; Pelzer, B.J.

    2008-01-01

    This study examines the effect of the distance between origin language and destination language on the reading skills of immigrant students, by building upon insights on the development of world languages, obtained from human population genetics. Lower-level research units are 1759 first-generation

  5. Aap, Noot, Mustafa… : Het effect van taalafstand en koloniaal verleden op leesprestaties

    NARCIS (Netherlands)

    Kooistra, Jan-Paul; Ultee, Wout; Pelzer, Ben

    2008-01-01

    Summary A is for apple, B is for Bushra: The influence of language distance and colonial experience on reading This study examines the effect of the distance between origin language and destination language on the reading skills of immigrant students, by building upon insights on the development of

  6. AAPS-FDA workshop white paper : Microdialysis principles, application and regulatory perspectives

    NARCIS (Netherlands)

    Chaurasia, Chandra S.; Mueller, Markus; Bashaw, Edward D.; Benfeldt, Eva; Bolinder, Jan; Bullock, Ross; Bungay, Peter M.; DeLange, Elizabeth C. M.; Derendorf, Hartmut; Elmquist, William F.; Hammarlund-Udenaes, Margareta; Joukhadar, Christian; Kellogg, Dean L.; Lunte, Craig E.; Nordstrom, Carl Henrik; Rollema, Hans; Sawchuk, Ronald J.; Cheung, Belinda W. Y.; Shah, Vinod P.; Stahle, Lars; Ungerstedt, Urban; Welty, Devin F.; Yeo, Helen

    2007-01-01

    Many decisions in drug development and medical practice are based on measuring blood concentrations of endogenous and exogenous molecules. Yet most biochemical and pharmacological events take place in the tissues. Also, most drugs with few notable exceptions exert their effects not within the bloods

  7. Cultural bias in the AAP's 2012 Technical Report and Policy Statement on male circumcision

    NARCIS (Netherlands)

    Frisch, M.; Aigrain, Y.; Barauskas, V.; Bjarnason, R.; Boddy, S.A.; Czauderna, P.; Gier, R.P.E. de; Jong, T.P. de; Fasching, G.; Fetter, W.; Gahr, M.; Graugaard, C.; Greisen, G.; Gunnarsdottir, A.; Hartmann, W.; Havranek, P.; Hitchcock, R.; Huddart, S.; Janson, S.; Jaszczak, P.; Kupferschmid, C.; Lahdes-Vasama, T.; Lindahl, H.; Macdonald, N.; Markestad, T.; Martson, M.; Nordhov, S.M.; Palve, H.; Petersons, A.; Quinn, F.; Qvist, N.; Rosmundsson, T.; Saxen, H.; Soder, O.; Stehr, M.; Loewenich, V.C. von; Wallander, J.; Wijnen, R.

    2013-01-01

    The American Academy of Pediatrics recently released its new Technical Report and Policy Statement on male circumcision, concluding that current evidence indicates that the health benefits of newborn male circumcision outweigh the risks. The technical report is based on the scrutiny of a large numbe

  8. Cultural bias in the AAP's 2012 Technical Report and Policy Statement on male circumcision

    DEFF Research Database (Denmark)

    Frisch, Morten; Aigrain, Yves; Barauskas, Vidmantas;

    2013-01-01

    The American Academy of Pediatrics recently released its new Technical Report and Policy Statement on male circumcision, concluding that current evidence indicates that the health benefits of newborn male circumcision outweigh the risks. The technical report is based on the scrutiny of a large...... number of complex scientific articles. Therefore, while striving for objectivity, the conclusions drawn by the 8 task force members reflect what these individual physicians perceived as trustworthy evidence. Seen from the outside, cultural bias reflecting the normality of nontherapeutic male circumcision...... associations and societies for pediatrics, pediatric surgery, and pediatric urology in Northern Europe. To these authors, only 1 of the arguments put forward by the American Academy of Pediatrics has some theoretical relevance in relation to infant male circumcision; namely, the possible protection against...

  9. De grijze aap: ouderen, communicatie en consumentengedrag vanuit het perspectief van de evolutie

    OpenAIRE

    Sikkel, D.

    2010-01-01

    Lang geleden, voordat er mensen bestonden, bleven alle dieren vruchtbaar tot hun dood. De afgelopen vijf miljoen jaar hebben wij ons ontwikkeld tot de enige diersoort met een menopauze. Kennelijk was dit ergens goed voor; de natuur geeft deze onvruchtbare extra tijd van leven niet cadeau. Het nut van de vijftigplusser, en daarmee zijn natuurlijke gedrag, moet er dus zijn, maar het staat niet scherp op ons netvlies. Marketeers en communicatieprofessionals, die ook de oudere doelgroep in het ha...

  10. Emerging regenerative approaches for periodontal reconstruction: a systematic review from the AAP Regeneration Workshop.

    Science.gov (United States)

    Lin, Zhao; Rios, Hector F; Cochran, David L

    2015-02-01

    More than 30 years have passed since the first successful application of regenerative therapy for treatment of periodontal diseases. Despite being feasible, periodontal regeneration still faces numerous challenges, and complete restoration of structure and function of the diseased periodontium is often considered an unpredictable task. This review highlights developing basic science and technologies for potential application to achieve reconstruction of the periodontium. A comprehensive search of the electronic bibliographic database PubMed was conducted to identify different emerging therapeutic approaches reported to influence either biologic pathways and/or tissues involved in periodontal regeneration. Each citation was assessed based on its abstract, and the full text of potentially eligible reports was retrieved. Based on the review of the full papers, their suitability for inclusion in this report was determined. In principle, only reports from scientifically well-designed studies that presented preclinical in vivo (animal studies) or clinical (human studies) evidence for successful periodontal regeneration were included. Hence, in vitro studies, namely those conducted in laboratories without any live animals, were excluded. In case of especially recent and relevant reviews with a narrow focus on specific regenerative approaches, they were identified as such, and thereby the option of referring to them to summarize the status of a specific approach, in addition to or instead of listing each separately, was preserved. Admittedly, the presence of subjectivity in the selection of studies to include in this overview cannot be excluded. However, it is believed that the contemporary approaches described in this review collectively represent the current efforts that have reported preclinical or clinical methods to successfully enhance regeneration of the periodontium. Today's challenges facing periodontal regenerative therapy continue to stimulate important research and clinical development, which, in turn, shapes the current concept of periodontal tissue engineering. Emerging technologies--such as stem cell therapy, bone anabolic agents, genetic approaches, and nanomaterials--also offer unique opportunities to enhance the predictability of current regenerative surgical approaches and inspire development of novel treatment strategies. PMID:25644297

  11. Particle size analysis: AAPS workshop report, cosponsored by the Food and Drug Administration and the United States Pharmacopeia

    OpenAIRE

    Burgess, Diane J.; Duffy, Eric; Etzler, Frank; Hickey, Anthony J.

    2004-01-01

    The concepts of particle engineering and dosage form design have become dominant themes in pharmaceutical manufacturing. This trend is not simply a reflection of the development of new, more sophisticated manufacturing methods of particles or dispersed systems but also recognition of the importance of quality control even in more traditional manufacturing processes. However, the diversity of particle treatments, methods of particle size analysis, expression and interpretation of data, and pro...

  12. Sports Injury Prevention Tip Sheet

    Science.gov (United States)

    ... Apply Advertise with AAP Advertising on AAP.org Advertising on AAP Journals & Publications AAP Mailing and eMail List Corporate Relationships Conflict of Interest and Industry Relations Sponsorships Corporate Friends of Children Fund Corporate Relationship ...

  13. Onderzoek naar de mogelijke inductie van leuco-myelo-encephalopathie door inhalatoire blootstelling van een aap aan pyrolisaat van versneden heroine

    NARCIS (Netherlands)

    van der Laan JW; Timmerman A; Marra M; Wolters EC; Loeber JG; Dormans JAMA; Schipper MEI; Boot R

    1986-01-01

    Nadat vanaf 1980 enige tientallen personen het slachtoffer zijn geworden van een heroine-leuko-encephalopathie als gevolg van het "chinezen" van vnl. heroine zijn gedurende twee jaar geen slachtoffers gemeld. Twee slachtoffers in 1984, die bovendien een grote hoeveelheid heroine in het b

  14. Periodontitis and systemic diseases : a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases

    NARCIS (Netherlands)

    Linden, Gerry J; Herzberg, Mark C; van Winkelhoff, Arie

    2013-01-01

    BACKGROUND: There has been an explosion in research into possible associations between periodontitis and various systemic diseases and conditions. AIM: To review the evidence for associations between periodontitis and various systemic diseases and conditions, including chronic obstructive pulmonary

  15. Draamateatris müüakse pähkleid, aga ükski ei taha osta / Priit Pedajas ; interv. Aap Egorov

    Index Scriptorium Estoniae

    Pedajas, Priit, 1954-

    1999-01-01

    Eesti Draamateatris Madis Kõivu näidend "Kui me Moondsundi Vasseliga kreeka pähkleid kauplesime, siis ükski ei tahtnud osta", lavastaja Priit Pedajas, kunstnik Pille Jänes, osades Ita Ever, Andrus Vaarik, Ain Lutsepp, Rein Oja, Laine Mägi, Kersti Kreismann jt. Esietendus 9. juunil

  16. Purification and characterization of novel cationic peroxidases from Asparagus acutifolius L. with biotechnological applications.

    Science.gov (United States)

    Guida, Vincenzo; Cantarella, Maria; Chambery, Angela; Mezzacapo, Maria C; Parente, Augusto; Landi, Nicola; Severino, Valeria; Di Maro, Antimo

    2014-08-01

    Four novel basic peroxidases, named AaP-1, AaP-2, AaP-3, and AaP-4, were purified from Asparagus acutifolius L. seeds by cation-exchange and gel filtration chromatographies. The four proteins showed a similar electrophoretic mobility of 46 kDa while, by MALDI-TOF MS, different Mr values of 42758.3, 41586.9, 42796.3, and 41595.5 were determined for AaP-1, AaP-2, AaP-3, and AaP-4, respectively. N-terminal sequences of AaPs 1-4 up to residue 20 showed a high percentage of identity with the peroxidase from Glycine max. In addition, AaP-1, AaP-2, AaP-3, and AaP-4 were found to be glycoproteins, containing 21.75, 22.27, 25.62, and 18.31 % of carbohydrates, respectively. Peptide mapping and MALDI-TOF MS analysis of AaPs 1-4 showed that the structural differences between AaP-1 and AaP-2 and AaP-3 and AaPs-4 were mainly due to their glycan content. We also demonstrate that AaPs were able to remove phenolic compounds from olive oil mill wastewaters with a higher catalytic efficiency with respect to horseradish peroxidase, thus representing candidate enzymes for potential biotechnological applications in the environmental field.

  17. NCBI nr-aa BLAST: CBRC-MMUS-08-0067 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-08-0067 gb|AAP03536.1| melanocortin 1 receptor [Chaetodipus intermedius] ...gb|AAP03538.1| melanocortin 1 receptor [Chaetodipus intermedius] gb|AAP03570.1| melanocortin 1 receptor [Chaetodipus intermedius...] gb|AAP03572.1| melanocortin 1 receptor [Chaetodipus intermedius] gb|AAP03590.1| melano...cortin 1 receptor [Chaetodipus intermedius] gb|AAP03592.1| melanocortin 1 receptor [Chaetodipus intermediu...s] gb|AAP03594.1| melanocortin 1 receptor [Chaetodipus intermedius] gb|AAP03596.1|

  18. Talking to Kids and Teens About Social Media and Sexting

    Science.gov (United States)

    ... Current Openings How to Apply Advertise with AAP Advertising on AAP.org Advertising on AAP Journals & Publications AAP Mailing and eMail ... on Facebook today?” “Any new chats recently?” “Anyone text you today?” Share a bit about your daily ...

  19. Interaction mechanism between 4-aminoantipyrine and the enzyme lysozyme

    International Nuclear Information System (INIS)

    4-Aminoantipyrine (AAP) is scarcely administered as a kind of analgesic drug because of the side effect. The residue of AAP in the environment poses a potential threat to human health. To evaluate the toxicity of AAP at the protein level, the effects of AAP on lysozyme were investigated using spectroscopic and molecular docking methods. Addition of AAP effectively quenched the intrinsic fluorescence of lysozyme. Static quenching of lysozyme by AAP revealed the formation of complex. After the inner filter effect was eliminated, the number of binding sites, the binding constant and the thermodynamic parameters were measured, and indicated that AAP can spontaneously bind with lysozyme through hydrophobic interactions with one binding site. Molecular docking results revealed that AAP bound into the enzyme active site and interacted with the Trp 62 and Trp 63 residues of lysozyme, which illustrated that the lysozyme activity was inhibited by AAP, in accordance with the results of the lysozyme activity experiment. Furthermore, the binding of AAP can result in demonstrable change of the conformation of lysozyme. This work is helpful for clarifying the molecular toxic mechanism of AAP in vivo. - Highlights: → This work established the binding mode of AAP with lysozyme in molecular level. → Mechanism was explored by multiple spectroscopic and molecular docking methods. → AAP can inhibit lysozyme activity and induce conformational changes in lysozyme.

  20. Characterization of aspartyl aminopeptidase from Toxoplasma gondii

    Science.gov (United States)

    Zheng, Jun; Cheng, Ziying; Jia, Honglin; Zheng, Yonghui

    2016-01-01

    Aminopeptidases have emerged as new promising drug targets for the development of novel anti-parasitic drugs. An aspartyl aminopeptidase-like gene has been identified in the Toxoplasma gondii genome (TgAAP), although its function remains unknown. In this study, we characterized TgAAP and performed functional analysis of the gene product. Firstly, we expressed a functional recombinant TgAAP (rTgAAP) protein in Escherichia coli, and found that it required metal ions for activity and showed a substrate preference for N-terminal acidic amino acids Glu and Asp. Then, we evaluated the function and drug target potential of TgAAP using the CRISPR/Cas9 knockout system. Western blotting demonstrated the deletion of TgAAP in the knockout strain. Indirect immunofluorescence analysis showed that TgAAP was localized in the cytoplasm of the wild-type parasite, but was not expressed in the knockout strain. Phenotype analysis revealed that TgAAP knockout inhibited the attachment/invasion, replication, and substrate-specific activity in T. gondii. Finally, the activity of drug CID 23724194, previously described as targeting Plasmodium and malarial parasite AAP, was tested against rTgAAP and the parasite. Overall, TgAAP knockout affected the growth of T. gondii but did not completely abolish parasite replication and growth. Therefore, TgAAP may comprise a useful adjunct drug target of T. gondii. PMID:27678060

  1. NCBI nr-aa BLAST: CBRC-OANA-01-1968 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OANA-01-1968 gb|AAP13045.1| NADH dehydrogenase subunit 2 [Pseudochaenichthys georgi...anus] gb|AAP13046.1| NADH dehydrogenase subunit 2 [Pseudochaenichthys georgianus] AAP13045.1 0.17 23% ...

  2. NCBI nr-aa BLAST: CBRC-ATHA-05-0006 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ATHA-05-0006 gb|AAP45159.1| Plant viral-response family protein [Solanum bulbo...castanum] gb|AAP45189.1| Plant viral-response family protein [Solanum bulbocastanum] AAP45159.1 4e-13 23% ...

  3. Transcriptional regulation of cytosol and membrane alanyl-aminopeptidase in human T cell subsets.

    Science.gov (United States)

    Bukowska, Alicja; Tadje, Janine; Arndt, Marco; Wolke, Carmen; Kähne, Thilo; Bartsch, Jaqueline; Faust, Jürgen; Neubert, Klaus; Hashimoto, Yuichi; Lendeckel, Uwe

    2003-04-01

    Aminopeptidase inhibitors strongly affect the proliferation and function of immune cells in man and animals and are promising agents for the pharmacological treatment of inflammatory or autoimmune diseases. Membrane alanyl-aminopeptidase (mAAP) has been considered as the major target of these anti-inflammatory aminopeptidase inhibitors. Recent evidence also points to a role of the cytosol alanyl-aminopeptidase (cAAP) in the immune response. In this study we used quantitative RT-PCR to determine the mRNA expression of both cAAP and mAAP in resting and activated peripheral T cells and also in CD4+, CD8+, Th1, Th2 and Treg (CD4+ CD25+) subpopulations. Both mAAP and cAAP mRNAs were expressed in all cell types investigated, and in response to activation their expression appeared to be upregulated in CD8+ cells, but downregulated in Treg cells. In CD4+ cells, mAAP and cAAP mRNAs were affected in opposite ways in response to activation. The cAAP-specific inhibitor, PAQ-22, did not affect either cAAP or mAAP expression in activated CD4+ or CD8+ cells, whereas in activated Treg cells it markedly upregulated the mRNA levels of both aminopeptidases. The non-discriminatory inhibitor, phebestin, significantly increased the amount of mAAP and cAAP mRNA in CD4+ and that of cAAP in Treg cells.

  4. 2013年美国儿科学会《儿童和青少年2型糖尿病诊治指南》解读%Interpretation of AAP Management of Tpye 2 Diabetes Mellitus in Children and Adolescents

    Institute of Scientific and Technical Information of China (English)

    夏萍; 刘超

    2013-01-01

    For recent years,obesity and diabetes mellitus prevalence rates have been increasing year by year in children and adolescents.Treatment education and medication are not adequately available for the young patients.The first treatment guideline for children and adolescents has been published online in 2013 which provides the direction for practice.This article is comprehensive analysis of the part of guildeline,aiming to share with the issue-interested people.%近年来,儿童和青少年的肥胖与糖尿病发病率逐年增加,而多数对于T1DM及T2DM的教育与治疗药物并不适用于儿童和青少年患者.2013年,首个针对儿童与青少年新诊断T2DM管理指南在线发表,为临床诊疗提供了指导.本文对指南进行部分理解与说明,与同道共勉.

  5. Arylazopyrazoles as Light-Responsive Molecular Switches in Cyclodextrin-Based Supramolecular Systems.

    Science.gov (United States)

    Stricker, Lucas; Fritz, Eva-Corinna; Peterlechner, Martin; Doltsinis, Nikos L; Ravoo, Bart Jan

    2016-04-01

    A simple and high yield synthesis of water-soluble arylazopyrazoles (AAPs) featuring superior photophysical properties is reported. The introduction of a carboxylic acid allows the diverse functionalization of AAPs. Based on structural modifications of the switching unit the photophysical properties of the AAPs could be tuned to obtain molecular switches with favorable photostationary states. Furthermore, AAPs form stable and light-responsive host-guest complexes with β-cyclodextrin (β-CD). Our most efficient AAP shows binding affinities comparable to azobenzenes, but more effective switching and higher thermal stability of the Z-isomer. As a proof-of-principle, we investigated two CD-based supramolecular systems, containing either cyclodextrin vesicles (CDVs) or cyclodextrin-functionalized gold nanoparticles (CDAuNPs), which revealed excellent reversible, light-responsive aggregation and dispersion behavior. To conclude, AAPs have great potential to be incorporated as molecular switches in highly demanding and multivalent photoresponsive systems. PMID:26972671

  6. National trends in off-label use of atypical antipsychotics in children and adolescents in the United States.

    Science.gov (United States)

    Sohn, Minji; Moga, Daniela C; Blumenschein, Karen; Talbert, Jeffery

    2016-06-01

    The objectives of the study were as follows: to examine the national trend of pediatric atypical antipsychotic (AAP) use in the United States; to identify primary mental disorders associated with AAPs; to estimate the strength of independent associations between patient/provider characteristics and AAP use. Data are from the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey. First, average AAP prescription rates among 4 and 18-year-old patients between 1993 and 2010 were estimated. Second, data from 2007 to 2010 were combined and analyzed to identify primary mental disorders related to AAP prescription. Third, a multivariate logistic regression model was developed having the presence of AAP prescription as the dependent variable and patient/provider characteristics as explanatory variables. Adjusted odds ratios (AORs) with associated 95% confidence intervals (CIs) were estimated. Outpatient visits including an AAP prescription among 4 to 18-year-old patients significantly increased between 1993 and 2010 in the United States, and over 65% of those visits did not have diagnoses for US Food and Drug Administration-approved AAP indications. During 2007 to 2010, the most common mental disorder was attention-deficit hyperactivity disorder, accounting for 24% of total pediatric AAP visits. Among visits with attention-deficit hyperactivity disorder diagnosis, those with Medicaid as payer (AOR 1.66, 95% CI 1.01-2.75), comorbid mental disorders (e.g., psychoses AOR 3.34, 95% CI 1.35-8.26), and multiple prescriptions (4 or more prescriptions AOR 4.48, 95% CI 2.08-9.64) were more likely to have an AAP prescription. The off-label use of AAPs in children and adolescents is prevalent in the United States. Our study raises questions about the potential misuse of AAPs in the population. PMID:27281081

  7. Auricularia auricular polysaccharide-low molecular weight chitosan polyelectrolyte complex nanoparticles: Preparation and characterization

    Directory of Open Access Journals (Sweden)

    Wei Xiong

    2016-06-01

    Full Text Available Novel polyelectrolyte complex nanoparticles (AAP/LCS NPs were prepared in this study and these were produced by mixing negatively charged auricularia auricular polysaccharide (AAP with positively charged low molecular weight chitosan (LCS in an aqueous medium. The AAP was extracted and purified from auricularia auricular, and then characterized by micrOTOF-Q mass spectrometry, UV/Vis spectrophotometry, moisture analyzer and SEM. The yield, moisture, and total sugar content of the AAP were 4.5%, 6.2% and 90.12% (w/w, respectively. The AAP sample was water-soluble and exhibited white flocculence. The characteristics of AAP/LCS NPs, such as the particle size, zeta potential, morphology, FT-IR spectra, DSC were investigated. The results obtained revealed that the AAP/LCS NPs had a spherical shape with a diameter of 223 nm and a smooth surface, and the results of the FT-IR spectra and DSC investigations indicated that there was an electrostatic interaction between the two polyelectrolyte polymers. Bovine serum albumin (BSA, pI = 4.8 and bovine hemoglobin (BHb, pI = 6.8 were used as model drugs to investigate the loading and release features of the AAP/LCS NPs. The results obtained showed that the AAP/LCS NPs had a higher entrapment efficiency (92.6% for BHb than for BSA (81.5%. The cumulative release of BSA and BHb from AAP/LCS NPs after 24 h in vitro was 95.4% and 91.9%, respectively. The in vitro release demonstrated that AAP/LCS NPs provided a sustained release matrix suitable for the delivery of protein drugs. These studies demonstrate that AAP/LCS NPs have a very promising potential as a delivery system for protein drugs.

  8. Secondhand smoke in combination with ambient air pollution exposure is associated with increased CpG methylation and decreased expression of IFN-gamma in T effector cells and Foxp3 in T regulatory cells in children

    OpenAIRE

    Kohli, Arunima; Garcia, Marco A; Miller, Rachel L.; Maher, Christina; Humblet, Olivier; Hammond, S; Nadeau, Kari

    2012-01-01

    Abstract Background Secondhand smoke (SHS) and ambient air pollution (AAP) exposures have been associated with increased prevalence and severity of asthma and DNA modifications of immune cells. In the current study, we examined the association between SHS and AAP with DNA methylation and expression of interferon-gamma (IFN-γ) and forkhead box protein 3 (Foxp3) in T cell populations. Methods Subjects 7–18 years old were recruited from Fresno (high AAP; n ...

  9. Acetaminophen induces apoptosis in rat cortical neurons.

    Directory of Open Access Journals (Sweden)

    Inmaculada Posadas

    Full Text Available BACKGROUND: Acetaminophen (AAP is widely prescribed for treatment of mild pain and fever in western countries. It is generally considered a safe drug and the most frequently reported adverse effect associated with acetaminophen is hepatotoxicity, which generally occurs after acute overdose. During AAP overdose, encephalopathy might develop and contribute to morbidity and mortality. Our hypothesis is that AAP causes direct neuronal toxicity contributing to the general AAP toxicity syndrome. METHODOLOGY/PRINCIPAL FINDINGS: We report that AAP causes direct toxicity on rat cortical neurons both in vitro and in vivo as measured by LDH release. We have found that AAP causes concentration-dependent neuronal death in vitro at concentrations (1 and 2 mM that are reached in human plasma during AAP overdose, and that are also reached in the cerebrospinal fluid of rats for 3 hours following i.p injection of AAP doses (250 and 500 mg/kg that are below those required to induce acute hepatic failure in rats. AAP also increases both neuronal cytochrome P450 isoform CYP2E1 enzymatic activity and protein levels as determined by Western blot, leading to neuronal death through mitochondrial-mediated mechanisms that involve cytochrome c release and caspase 3 activation. In addition, in vivo experiments show that i.p. AAP (250 and 500 mg/kg injection induces neuronal death in the rat cortex as measured by TUNEL, validating the in vitro data. CONCLUSIONS/SIGNIFICANCE: The data presented here establish, for the first time, a direct neurotoxic action by AAP both in vivo and in vitro in rats at doses below those required to produce hepatotoxicity and suggest that this neurotoxicity might be involved in the general toxic syndrome observed during patient APP overdose and, possibly, also when AAP doses in the upper dosing schedule are used, especially if other risk factors (moderate drinking, fasting, nutritional impairment are present.

  10. Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children

    OpenAIRE

    Kohli Arunima; Garcia Marco A; Miller Rachel L; Maher Christina; Humblet Olivier; Hammond S; Nadeau Kari

    2012-01-01

    Abstract Background Secondhand smoke (SHS) and ambient air pollution (AAP) exposures have been associated with increased prevalence and severity of asthma and DNA modifications of immune cells. In the current study, we examined the association between SHS and AAP with DNA methylation and expression of interferon-gamma (IFN-γ) and forkhead box protein 3 (Foxp3) in T cell populations. Methods Subjects 7–18 years old were recruited from Fresno (high AAP; n = 62) and Stanford, CA (low AAP; n = 40...

  11. Aerobic Anoxygenic Phototrophic Bacteria in the Mid-Atlantic Bight and the North Pacific Gyre. Revised

    Science.gov (United States)

    Cottrell, Matthew T.; Mannino, Antonio; Kirchman, David L.

    2005-01-01

    The abundance of aerobic anoxygenic phototrophic (AM) bacteria, cyanobacteria and heterotrophs was examined in the Mid-Atlantic Bight and the central North Pacific gyre using infrared fluorescence microscopy coupled with image analysis and flow cytometry. AAP bacteria comprised 5% to 16% of total prokaryotes in the Atlantic but only 5% or less in the Pacific. In the Atlantic, AAP bacterial abundance was as much as 2-fold higher than Prochlorococcus and 10-folder higher than Synechococcus. In contrast, Prochlorococcus outnumbered AAP bacteria 5- to 50-fold in the Pacific. In both oceans, subsurface abundance maxima occurred within the photic zone, and AAP bacteria were least abundant below the 1% light depth. Concentrations of bacteriochlorophyll a (BChl a) were low (approx.1%) compared to chlorophyll a. Although the BChl a content of AAP bacteria per cell was typically 20- to 250-fold lower than the divinyl-chlorophyll a content of Prochlorococcus, in shelf break water the pigment content of AAP bacteria approached that of Prochlorococcus. The abundance of AAP bacteria rivaled some groups of strictly heterotrophic bacteria and was often higher than the abundance of known AAP genera (Erythrobacter and Roseobacter spp.). The distribution of AAP bacteria in the water column, which was similar in the Atlantic and the Pacific, was consistent with phototrophy.

  12. Chat, E-Mail, Web, and Chat Room Slang and Acronyms

    Science.gov (United States)

    ... Shop AAP Find a Pediatrician Family Life Medical Home Health Insurance Pediatric Specialists Family Dynamics Adoption & Foster Care Communication & Discipline Types of Families Media Work & Play ...

  13. Cyberbullying

    Science.gov (United States)

    ... Shop AAP Find a Pediatrician Family Life Medical Home Health Insurance Pediatric Specialists Family Dynamics Adoption & Foster Care Communication & Discipline Types of Families Media Work & Play ...

  14. Benefits of Limiting TV

    Science.gov (United States)

    ... Shop AAP Find a Pediatrician Family Life Medical Home Health Insurance Pediatric Specialists Family Dynamics Adoption & Foster Care Communication & Discipline Types of Families Media Work & Play ...

  15. Enzymuria in neonates receiving continuous intravenous infusion of gentamicin

    DEFF Research Database (Denmark)

    Colding, H; Brygge, K; Brendstrup, L;

    1992-01-01

    with non-treatment periods in the same newborn infant (33 infants). The same tendency applied to AAP. Newborn infants receiving continuous intravenous infusion of gentamicin were not found to be at greater risk of nephrotoxicity than those receiving intermittent gentamicin treatment, using NAG and AAP...

  16. The Effectiveness of the Academic Appeal Program at John A. Logan Community College.

    Science.gov (United States)

    Gallagher, Kathleen A.

    This study was conducted to determine the effectiveness of the Academic Appeal Program (AAP) in improving the retention of at-risk students at John A. Logan College (JALC) in Illinois. The AAP allows students whose poor academic performance results in ineligibility for financial aid to continue their schooling under a strict performance contract.…

  17. Increasing Availability to and Ascertaining Value of Asthma Action Plans in Schools through Use of Technology and Community Collaboration

    Science.gov (United States)

    Hanson, Tabitha K.; Aleman, Martha; Hart, Lacey; Yawn, Barbara

    2013-01-01

    Background: Approximately 9% of school-aged children in the United States have asthma. Since 1997, the Asthma Action Plan (AAP) has been recommended as an asthma self-management tool for individuals with asthma. In the school setting, the use of the AAP has been primarily dependent on communication between the family and the school through a paper…

  18. NCBI nr-aa BLAST: CBRC-GGOR-01-1322 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GGOR-01-1322 gb|AAP44475.1| transient receptor potential cation channel subfam...ily M member 4 splice variant C [Homo sapiens] gb|EAW52460.1| transient receptor potential cation channel, subfamily M, member 4, isoform CRA_a [Homo sapiens] AAP44475.1 3e-28 87% ...

  19. TEMPLATE POLYMERIZATION OF N-VINYLIMIDAZOLE ALONG POLY(METHACRYLIC ACID) IN WATER .3. MOLECULAR-WEIGHTS OF THE FORMED POLYMERS

    NARCIS (Netherlands)

    VANDEGRAMPEL, HT; TAN, YY; CHALLA, G

    1991-01-01

    The molecular weights of polymers formed in the template polymerization of N-vinylimidazole (VIm) along poly(methacrylic acid) (PMAA) in water at 50-degrees-C using 2,2'-azobis(2-amidinopropane)-2HCl (AAP) as initiator were determined for variable [PMAA] to [VIm]0 ratios, [VIm]0, [AAP]0, and templat

  20. A plasma membrane association module in yeast amino acid transporters

    NARCIS (Netherlands)

    Popov-Čeleketić, Dušan; Bianchi, Frans; Ruiz, Stephanie J; Meutiawati, Febrina; Poolman, Bert

    2016-01-01

    Amino acid permeases (AAPs) in the plasma membrane (PM) of Saccharomyces cerevisiae are responsible for the uptake of amino acids and involved in regulation of their cellular levels. Here, we report on a strong and complex module for PM association found in the C-terminal tail of AAPs. Using in sili

  1. Kinetic, spectroscopic, and X-ray crystallographic characterization of the functional E151H aminopeptidase from Aeromonas proteolytica.

    Science.gov (United States)

    Bzymek, Krzysztof P; Moulin, Aaron; Swierczek, Sabina I; Ringe, Dagmar; Petsko, Gregory A; Bennett, Brian; Holz, Richard C

    2005-09-13

    Glutamate151 (E151) has been shown to be catalytically essential for the aminopeptidase from Vibrio proteolyticus (AAP). E151 acts as the general acid/base during the catalytic mechanism of peptide hydrolysis. However, a glutamate residue is not the only residue capable of functioning as a general acid/base during catalysis for dinuclear metallohydrolases. Recent crystallographic characterization of the D-aminopeptidase from Bacillus subtilis (DppA) revealed a histidine residue that resides in an identical position to E151 in AAP. Because the active-site ligands for DppA and AAP are identical, AAP has been used as a model enzyme to understand the mechanistic role of H115 in DppA. Substitution of E151 with histidine resulted in an active AAP enzyme exhibiting a kcat value of 2.0 min(-1), which is over 2000 times slower than r AAP (4380 min(-1)). ITC experiments revealed that ZnII binds 330 and 3 times more weakly to E151H-AAP compared to r-AAP. UV-vis and EPR spectra of CoII-loaded E151H-AAP indicated that the first metal ion resides in a hexacoordinate/pentacoordinate equilibrium environment, whereas the second metal ion is six-coordinate. pH dependence of the kinetic parameters kcat and K(m) for the hydrolysis of L-leucine p-nitroanilide (L-pNA) revealed a change in an ionization constant in the enzyme-substrate complex from 5.3 in r-AAP to 6.4 in E151H-AAP, consistent with E151 in AAP being the active-site general acid/base. Proton inventory studies at pH 8.50 indicate the transfer of one proton in the rate-limiting step of the reaction. Moreover, the X-ray crystal structure of [ZnZn(E151H-AAP)] has been solved to 1.9 A resolution, and alteration of E151 to histidine does not introduce any major conformational changes to the overall protein structure or the dinuclear ZnII active site. Therefore, a histidine residue can function as the general acid/base in hydrolysis reactions of peptides and, through analogy of the role of E151 in AAP, H115 in DppA likely

  2. Use of the adult attachment projective picture system in psychodynamic psychotherapy with a severely traumatized patient.

    Science.gov (United States)

    George, Carol; Buchheim, Anna

    2014-01-01

    The following case study is presented to facilitate an understanding of how the attachment information evident from Adult Attachment Projective Picture System (AAP) assessment can be integrated into a psychodynamic perspective in making therapeutic recommendations that integrate an attachment perspective. The Adult Attachment Projective Picture System (AAP) is a valid representational measure of internal representations of attachment based on the analysis of a set of free response picture stimuli designed to systematically activate the attachment system (George and West, 2012). The AAP provides a fruitful diagnostic tool for psychodynamic-oriented clinicians to identify attachment-based deficits and resources for an individual patient in therapy. This paper considers the use of the AAP with a traumatized patient in an inpatient setting and uses a case study to illustrate the components of the AAP that are particularly relevant to a psychodynamic conceptualization. The paper discusses also attachment-based recommendations for intervention.

  3. Acetaminophen induces human neuroblastoma cell death through NFKB activation.

    Directory of Open Access Journals (Sweden)

    Inmaculada Posadas

    Full Text Available Neuroblastoma resistance to apoptosis may contribute to the aggressive behavior of this tumor. Therefore, it would be relevant to activate endogenous cellular death mechanisms as a way to improve neuroblastoma therapy. We used the neuroblastoma SH-SY5Y cell line as a model to study the mechanisms involved in acetaminophen (AAP-mediated toxicity by measuring CYP2E1 enzymatic activity, NFkB p65 subunit activation and translocation to the nucleus, Bax accumulation into the mitochondria, cytochrome c release and caspase activation. AAP activates the intrinsic death pathway in the SH-SY5Y human neuroblastoma cell line. AAP metabolism is partially responsible for this activation, because blockade of the cytochrome CYP2E1 significantly reduced but did not totally prevent, AAP-induced SH-SY5Y cell death. AAP also induced NFkB p65 activation by phosphorylation and its translocation to the nucleus, where NFkB p65 increased IL-1β production. This increase contributed to neuroblastoma cell death through a mechanism involving Bax accumulation into the mitochondria, cytochrome c release and caspase3 activation. Blockade of NFkB translocation to the nucleus by the peptide SN50 prevented AAP-mediated cell death and IL-1β production. Moreover, overexpression of the antiapoptotic protein Bcl-x(L did not decrease AAP-mediated IL-1β production, but prevented both AAP and IL-1β-mediated cell death. We also confirmed the AAP toxic actions on SK-N-MC neuroepithelioma and U87MG glioblastoma cell lines. The results presented here suggest that AAP activates the intrinsic death pathway in neuroblastoma cells through a mechanism involving NFkB and IL-1β.

  4. Monoclonal antibodies against accumulation-associated protein affect EPS biosynthesis and enhance bacterial accumulation of Staphylococcus epidermidis.

    Directory of Open Access Journals (Sweden)

    Jian Hu

    Full Text Available Because there is no effective antibiotic to eradicate Staphylococcus epidermidis biofilm infections that lead to the failure of medical device implantations, the development of anti-biofilm vaccines is necessary. Biofilm formation by S. epidermidis requires accumulation-associated protein (Aap that contains sequence repeats known as G5 domains, which are responsible for the Zn(2+-dependent dimerization of Aap to mediate intercellular adhesion. Antibodies against Aap have been reported to inhibit biofilm accumulation. In the present study, three monoclonal antibodies (MAbs against the Aap C-terminal single B-repeat construct followed by the 79-aa half repeat (AapBrpt1.5 were generated. MAb(18B6 inhibited biofilm formation by S. epidermidis RP62A to 60% of the maximum, while MAb(25C11 and MAb(20B9 enhanced biofilm accumulation. All three MAbs aggregated the planktonic bacteria to form visible cell clusters. Epitope mapping revealed that the epitope of MAb(18B6, which recognizes an identical area within AapBrpt constructs from S. epidermidis RP62A, was not shared by MAb(25C11 and MAb(20B9. Furthermore, all three MAbs were found to affect both Aap expression and extracellular polymeric substance (EPS, including extracellular DNA and PIA biosynthesis in S. epidermidis and enhance the cell accumulation. These findings contribute to a better understanding of staphylococcal biofilm formation and will help to develop epitope-peptide vaccines against staphylococcal infections.

  5. Patterns in Abundance, Cell Size and Pigment Content of Aerobic Anoxygenic Phototrophic Bacteria along Environmental Gradients in Northern Lakes.

    Directory of Open Access Journals (Sweden)

    Lisa Fauteux

    Full Text Available There is now evidence that aerobic anoxygenic phototrophic (AAP bacteria are widespread across aquatic systems, yet the factors that determine their abundance and activity are still not well understood, particularly in freshwaters. Here we describe the patterns in AAP abundance, cell size and pigment content across wide environmental gradients in 43 temperate and boreal lakes of Québec. AAP bacterial abundance varied from 1.51 to 5.49 x 105 cells mL-1, representing <1 to 37% of total bacterial abundance. AAP bacteria were present year-round, including the ice-cover period, but their abundance relative to total bacterial abundance was significantly lower in winter than in summer (2.6% and 7.7%, respectively. AAP bacterial cells were on average two-fold larger than the average bacterial cell size, thus AAP cells made a greater relative contribution to biomass than to abundance. Bacteriochlorophyll a (BChla concentration varied widely across lakes, and was not related to AAP bacterial abundance, suggesting a large intrinsic variability in the cellular pigment content. Absolute and relative AAP bacterial abundance increased with dissolved organic carbon (DOC, whereas cell-specific BChla content was negatively related to chlorophyll a (Chla. As a result, both the contribution of AAP bacteria to total prokaryotic abundance, and the cell-specific BChla pigment content were positively correlated with the DOC:Chla ratio, both peaking in highly colored, low-chlorophyll lakes. Our results suggest that photoheterotrophy might represent a significant ecological advantage in highly colored, low-chlorophyll lakes, where DOC pool is chemically and structurally more complex.

  6. Alarm Reduction Processing of Advanced Nuclear Power Plant Using Data Mining and Active Database Technologies

    International Nuclear Information System (INIS)

    The purpose of the Advanced Alarm Processing (AAP) is to extract only the most important and the most relevant data out of large amount of available information. It should be noted that the integrity of the knowledge base is the most critical in developing a reliable AAP. This paper proposes a new approach to an AAP by using Event-Condition-Action(ECA) rules that can be automatically triggered by an active database. Also this paper proposed a knowledge acquisition method using data mining techniques to obtain the integrity of the alarm knowledge

  7. Cow's milk - infants

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/002448.htm Cow's milk - infants To use the sharing features on this ... old, you should not feed your baby cow's milk, according to the American Academy of Pediatrics (AAP). ...

  8. 78 FR 57874 - Federal Property Suitable as Facilities to Assist the Homeless

    Science.gov (United States)

    2013-09-20

    ....) Comments: Off-site removal only; no future agency use; residential; fair conditions; contact COE for more... kitchen Reasons: Extensive deterioration Tennessee J0139 Milan AAP Milan TN 38358 Landholding Agency:...

  9. Blonanserin Augmentation of Atypical Antipsychotics in Patients with Schizophrenia-Who Benefits from Blonanserin Augmentation?: An Open-Label, Prospective, Multicenter Study

    Science.gov (United States)

    Woo, Young Sup; Park, Joo Eon; Kim, Do-Hoon; Sohn, Inki; Hwang, Tae-Yeon; Park, Young-Min; Jon, Duk-In; Jeong, Jong-Hyun

    2016-01-01

    Objective The purpose of this study was to investigate the efficacy and tolerability of atypical antipsychotics (AAPs) with augmentation by blonanserin in schizophrenic patients. Methods aA total of 100 patients with schizophrenia who were partially or completely unresponsive to treatment with an AAP were recruited in this 12-week, open-label, non-comparative, multicenter study. Blonanserin was added to their existing AAP regimen, which was maintained during the study period. Efficacy was primarily evaluated using the Positive and Negative Syndrome Scale (PANSS) at baseline and at weeks 2, 4, 8, and 12. Predictors for PANSS response (≥20% reduction) were investigated. Results The PANSS total score was significantly decreased at 12 weeks of blonanserin augmentation (-21.0±18.1, F=105.849, pschizophrenia who were partially or completely unresponsive to treatment with an AAP.

  10. Rapid determination of total phenols in seawater by 4-aminoantipyrine colorimetry

    Digital Repository Service at National Institute of Oceanography (India)

    Kadam, A.N.; Bhangale, V.P.

    A rapid and efficient 4-aminoantipyrine (4-AAP) colorimetric method without any cleanup step to determine total phenols in seawater is described. Efficiency of the method for seawater using external addition of phenol concentrations with working...

  11. Iron Supplements Reduce Behavior Problems in Low Birth Weight Infants

    Science.gov (United States)

    ... Content Social Media Toolkit Donate Now Corporate Relationships Advertise with AAP Help/Feedback Recent a a a print email share Facebook Twitter Iron Supplements Reduce Behavior Problems in Low ...

  12. Social Development:: 2 Year Olds

    Science.gov (United States)

    ... in Action Medical Editor & Editorial Advisory Board Sponsors Sponsorship Opporunities Spread the Word Shop AAP Find a Pediatrician ... Ages & Stages > Toddler > Social Development: 2 Year Olds Ages & Stages Listen Español Text ...

  13. Concerns Girls Have about Puberty

    Science.gov (United States)

    ... in Action Medical Editor & Editorial Advisory Board Sponsors Sponsorship Opporunities Spread the Word Shop AAP Find a Pediatrician ... Content Article Body Girls have pubertal concerns and worries, too, including: Breast Development Some girls also have anxieties about breast development. ...

  14. Emotional Development: 2 Year Olds

    Science.gov (United States)

    ... in Action Medical Editor & Editorial Advisory Board Sponsors Sponsorship Opporunities Spread the Word Shop AAP Find a Pediatrician ... & Stages > Toddler > Emotional Development: 2 Year Olds Ages & Stages Listen Español Text ...

  15. Cognitive Development: Two-Year-Old

    Science.gov (United States)

    ... in Action Medical Editor & Editorial Advisory Board Sponsors Sponsorship Opporunities Spread the Word Shop AAP Find a Pediatrician ... & Stages > Toddler > Cognitive Development: Two-Year-Old Ages & Stages Listen Español Text ...

  16. Cognitive Development: One-Year-Old

    Science.gov (United States)

    ... in Action Medical Editor & Editorial Advisory Board Sponsors Sponsorship Opporunities Spread the Word Shop AAP Find a Pediatrician ... & Stages > Toddler > Cognitive Development: One-Year-Old Ages & Stages Listen Español Text ...

  17. Normal Child Behavior

    Science.gov (United States)

    ... in Action Medical Editor & Editorial Advisory Board Sponsors Sponsorship Opporunities Spread the Word Shop AAP Find a ... is "normal" depends upon the child's level of development, which can vary greatly among children of the ...

  18. Eyelid Problems

    Science.gov (United States)

    ... in Action Medical Editor & Editorial Advisory Board Sponsors Sponsorship Opporunities Spread the Word Shop AAP Find a ... irregular shape (astigmatism), it will threaten normal vision development and must be corrected as early as possible. ...

  19. Emotional Development: 1 Year Olds

    Science.gov (United States)

    ... in Action Medical Editor & Editorial Advisory Board Sponsors Sponsorship Opporunities Spread the Word Shop AAP Find a Pediatrician ... & Stages > Toddler > Emotional Development: 1 Year Olds Ages & Stages Listen Español Text ...

  20. Social Development: 1 Year Olds

    Science.gov (United States)

    ... in Action Medical Editor & Editorial Advisory Board Sponsors Sponsorship Opporunities Spread the Word Shop AAP Find a Pediatrician ... Ages & Stages > Toddler > Social Development: 1 Year Olds Ages & Stages Listen Español Text ...

  1. Physical Development: What's Normal? What's Not?

    Science.gov (United States)

    ... in Action Medical Editor & Editorial Advisory Board Sponsors Sponsorship Opporunities Spread the Word Shop AAP Find a Pediatrician ... > Puberty > Physical Development: What’s Normal? What’s Not? Ages & Stages Listen Español ...

  2. Baltimore Eesti Selts - 75 / Vilve Ladon ; fotod: Fred Ise

    Index Scriptorium Estoniae

    Ladon, Vilve

    2010-01-01

    Baltimore Eesti Majas tähistati 2. okt. 2010 Baltimore Eesti Seltsi aastapäeva. Eesti suursaatkonna esimene sekretär poliitilistes küsimustes Aap Neljas edastas president Toomas Hendrik Ilvese tervituse

  3. Asparaginase-associated pancreatitis in children with acute lymphoblastic leukaemia in the NOPHO ALL2008 protocol

    DEFF Research Database (Denmark)

    Raja, Raheel A; Schmiegelow, Kjeld; Albertsen, BK;

    2014-01-01

    L-asparaginase is an important drug in the treatment of childhood acute lymphoblastic leukaemia (ALL). Treatment is associated with several toxicities, including acute pancreatitis. Clinical course, presentation, re-exposure to L-asparginase after pancreatitis and risk of recurrent pancreatitis...... within an asparaginase-intensive protocol has been poorly reported. Children (1-17 years) on the ongoing Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL2008 protocol with asparaginase-associated pancreatitis (AAP) diagnosed between 2008 and 2012 were identified through the online NOPHO...... with AAP with a cumulative risk of AAP of 5·9%. AAP occurred after a median of five doses (range 1-13), and 11 d (median) from the latest administration of PEG-Asparaginase. Thirteen patients developed pseudocysts (30%) and 11 patients developed necrosis (25%). One patient died from pancreatitis. Twelve...

  4. Hib Photos

    Science.gov (United States)

    ... St. Paul, Minnesota Cerebrospinal fluid culture positive for Haemophilus influenzae , type b (Gram stain) www.vaccineinformation.org/photos/hib_aap001.jpg Copyright American Academy of Pediatrics Haemophilus influenzae type b. Cellulitis of the arm proven by blood culture ...

  5. Swimming Pool Safety

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Safety & Prevention Immunizations All Around At Home At Play ... Español Text Size Email Print Share Swimming Pool Safety Page Content ​What is the best way to ...

  6. Ecology of aerobic anoxygenic phototrophs in aquatic environments.

    Science.gov (United States)

    Koblížek, Michal

    2015-11-01

    Recognition of the environmental role of photoheterotrophic bacteria has been one of the main themes of aquatic microbiology over the last 15 years. Aside from cyanobacteria and proteorhodopsin-containing bacteria, aerobic anoxygenic phototrophic (AAP) bacteria are the third most numerous group of phototrophic prokaryotes in the ocean. This functional group represents a diverse assembly of species which taxonomically belong to various subgroups of Alpha-, Beta- and Gammaproteobacteria. AAP bacteria are facultative photoheterotrophs which use bacteriochlorophyll-containing reaction centers to harvest light energy. The light-derived energy increases their bacterial growth efficiency, which provides a competitive advantage over heterotrophic species. Thanks to their enzymatic machinery AAP bacteria are active, rapidly growing organisms which contribute significantly to the recycling of organic matter. This chapter summarizes the current knowledge of the ecology of AAP bacteria in aquatic environments, implying their specific role in the microbial loop.

  7. Feeding Vegetarian and Vegan Infants and Toddlers

    Science.gov (United States)

    ... Men For Women For Seniors Feeding Vegetarian and Vegan Infants and Toddlers By Dayle Hayes, MS, RD ... of Pediatrics (AAP) agree: Well-planned vegetarian and vegan eating patterns are healthy for infants and toddlers. ...

  8. Circumcision

    Science.gov (United States)

    Circumcision is a surgical procedure to remove the foreskin, the skin that covers the tip of the ... AAP), there are medical benefits and risks to circumcision. Possible benefits include a lower risk of urinary ...

  9. Normal Functioning Family

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Español Text Size Email Print Share Normal Functioning Family Page Content Article Body Is there any way ...

  10. Family Disruptions

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Life Listen Español Text Size Email Print Share Family Disruptions Page Content Article Body No matter how ...

  11. Roles within the Family

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Text Size Email Print Share Roles Within the Family Page Content Article Body Families are not democracies. ...

  12. Family Arguments

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Life Listen Español Text Size Email Print Share Family Arguments Page Content Article Body We seem to ...

  13. Approaches to. Establish for Major Food Aller

    Science.gov (United States)

    ... J. Food Treatments to ibdtpe The best example of food prod@s that ... AAP) dct~~~~$ that ~~f~~~~a could be considered 'hypoallergenic” if challenge ...

  14. Spontaneous Ejaculations in an Adolescent With Olanzapine Use: Case Report.

    Science.gov (United States)

    Yektaş, Çiğdem; Tufan, Ali Evren

    2016-01-01

    Olanzapine (OLZ) is a second-generation atypical antipsychotic (AAP) frequently used in acute and maintenance treatment of children and adolescents with psychotic disorders. Most commonly reported sexual problems caused by AAPs are decreases in libido or arousal, erectile dysfunctions, reduced/abnormal ejaculations, and problems in achieving or maintaining orgasm. Olanzapine is less commonly implicated for those adverse effects, which may reflect its more selective affinity to dopaminergic receptors or more transient effects on prolactin levels. Sexual dysfunction with AAPs, including OLZ, is reported predominantly in adult patients and adverse sexual effects in prepubertal/peripubertal patients with psychosis received scant attention. Studies and reports of sexual adverse effects of AAPs in this special population may benefit clinicians. Therefore, in this study, we report an adolescent male patient with psychosis who developed spontaneous ejaculations with OLZ and whose complaints remitted with change in treatment. PMID:26882319

  15. Use of the Adult Attachment Projective Picture System in Psychodynamic Psychotherapy with a Severely Traumatized Patient

    Directory of Open Access Journals (Sweden)

    Carol eGeorge

    2014-08-01

    Full Text Available The Adult Attachment Projective Picture System (AAP is a valid representational measure of internal representations of attachment based on the analysis of a set of free response picture stimuli designed to systematically activate the attachment system (George & West, 2012. The AAP provides a fruitful diagnostic tool for psychodynamic-oriented clinicians to identify attachment-based deficits and resources for an individual patient in therapy. This paper considers the use of the AAP with a traumatized patient in an inpatient setting and uses a case study to illustrate the components of the AAP that are particularly relevant to a psychodynamic conceptualization. The paper discusses also attachment-based recommendations for intervention.

  16. Pediatricians: Kids Need 'Media Use Plan' from Parents

    Science.gov (United States)

    ... in media also can promote unhealthy eating, substance abuse and risky sexual conduct. The AAP recommends that parents prioritize creative, unplugged playtime for infants and toddlers. A child's exposure to media can start as early as ...

  17. Quinone-Amino Acid Conjugates Targeting Leishmania Amino Acid Transporters

    OpenAIRE

    Federica Prati; Adele Goldman-Pinkovich; Federica Lizzi; Federica Belluti; Roni Koren; Dan Zilberstein; Maria Laura Bolognesi

    2014-01-01

    The aim of the present study was to investigate the feasibility of targeting Leishmania transporters via appropriately designed chemical probes. Leishmania donovani, the parasite that causes visceral leishmaniasis, is auxotrophic for arginine and lysine and has specific transporters (LdAAP3 and LdAAP7) to import these nutrients. Probes 1-15 were originated by conjugating cytotoxic quinone fragments (II and III) with amino acids (i.e. arginine and lysine) by means of an amide linkage. The toxi...

  18. Gene : CBRC-OCUN-01-0570 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available asal 1 receptor 2 [Homo sapiens] sp|Q8NFZ6|VN1R2_HUMAN Vomeronasal type-1 receptor 2 (V1r-like receptor 2) (...hGPCR25) dbj|BAB89320.1| putative G-protein coupled receptor [Homo sapiens] gb|AAP85616.1| pheromone receptor [Homo sapie...ns] gb|AAP85617.1| pheromone receptor [Homo sapiens] 1e-11 34% gnl|U...VISISTTCLLSVFQAITISPMNSRWAESKPKLQRLLAFPVTKTDTAIGILSTCHDVLWFLLMLWASGSTVFILHCTGRGSNTFIRATSCQDAARDHSSPKNPIEHLGLSLLLAFQLPVPLFLSHKCCVCTGRKRQFSQFRRI ...

  19. The combination effects of acetaminophen and N-acetylcysteine on cytokines production and NF-κB activation of lipopolysaccharide-challenged piglet mononuclear phagocytes in vitro and in vivo.

    Science.gov (United States)

    Qiu, Yinsheng; Zhang, Jiawei; Liu, Yu; Ma, Hongwei; Cao, Fangyuan; Xu, Jun; Hou, Yongqing; Xu, Lingyun

    2013-04-15

    Lipopolysaccharide (LPS) is a known activator of mononuclear phagocytes. LPS activates the pro-inflammatory gene expression and induces the release of mediators/cytokines by TLR4-NF-κB signaling pathway. The purpose of this study was to investigate the effects of acetaminophen (AAP) and N-acetylcysteine (NAC), individually as well as in combination on LPS-induced cytokines production and NF-κB activation in piglets. AAP (0.125-1.0mM) and NAC (0.0625-1.0mM) down-regulate the expression of cytokines and inhibit NF-κB p65 protein transfer from the cytoplasm to the nucleus in vitro. NAC enhances the inhibition action of AAP on cytokines expression in vitro. IL-6 in piglet plasma of the AAP group (mixed feed concentration of 600 mg/kg) was significantly reduced (Ppiglet plasma of the NAC group (mixed feeding concentration of 1200 mg/kg) were significantly lower at 3h after LPS stimulation (Ppiglet plasma of AAP (mixed feed concentration of 600 mg/kg) plus NAC (mixed feeding concentration of 1200 mg/kg) group were significantly lower (P<0.05) at 3h after LPS activation. The level of IL-10 in the group with AAP plus NAC was significantly lower (P<0.05) at 24h after LPS stimulation, while the rest of the inflammatory cytokines were returned to the original levels. The NF-κB p65 concentration ratio had significantly reduced (P<0.05) when AAP and NAC were used in combination. In summary, NAC could enhance the anti-inflammatory effects of AAP both in vitro and in vivo.

  20. Diet quality, nutrient intake, weight status, and feeding environments of girls meeting or exceeding the American Academy of Pediatrics recommendations for total dietary fat

    OpenAIRE

    Lee, Y.; Birch, L. L.

    2002-01-01

    The American Academy of Pediatrics (AAP) recommends that children consume no more than 30% but no less than 20% of energy as dietary fat intake, and tills recommendation, is accompanied by suggestions that fat calories should be replaced by eating more grain products, fruits, vegetables, low fat datiy products, beans, lean meat, poultry, fish, and other protein rich foods. In comparing diets of girls meeting this AAP recommendation with girls who consumed diets higher in fat, we noted that gi...

  1. CT and MR imaging in patients with localized acute abdominal pain

    International Nuclear Information System (INIS)

    Full text: Acute abdominal pain (AAP) is one of the most common causes for admissions to emergency departments. Clinical presentation, physical and laboratory examinations are often inconclusive and, therefore, imaging evaluation is required. Ultrasonography is efficient in the evaluation of gallbladder and gynecologic conditions and it is considered the first-line examination in many centres. Plain radiography and barium studies are often falsely normal or non-specific, especially in the most common conditions related with rightsided AAP and their use has significantly decreased. CT is a rapid and accurate imaging modality in the diagnosis of common (appendicitis, acute cholecystitis, biliary obstruction, duodenal ulcer perforation) or uncommon (mesenteric adenitis, liver abscess, cholangitis etc) conditions associated with right-sided AAP. CT may demonstrate a number of either specific or sensitive imaging findings for the confident diagnosis of diseases manifested with AAP. Moreover, CT has the advantage to suggest alternative diagnoses, if the suspected clinical diagnosis is unconfirmed. Different examination protocols and different strategies for the application of oral-rectal-intravenous contrast agents have been proposed to balance diagnostic accuracy to time effectiveness and radiation dose. MRI is suggested for AAP related to biliary abnormalities or to gynecologic diseases and it may be used as a complementary examination in pregnant patients. Imaging evaluation is an indispensable part in the diagnostic work up of most patients with AAP. CT has gained widespread acceptance, as offering more accurate and confident diagnosis and its use has changed management of the patients in 28-60% of the cases

  2. Abundance and genetic diversity of aerobic anoxygenic phototrophic bacteria of coastal regions of the pacific ocean.

    Science.gov (United States)

    Ritchie, Anna E; Johnson, Zackary I

    2012-04-01

    Aerobic anoxygenic phototrophic (AAP) bacteria are photoheterotrophic microbes that are found in a broad range of aquatic environments. Although potentially significant to the microbial ecology and biogeochemistry of marine ecosystems, their abundance and genetic diversity and the environmental variables that regulate these properties are poorly understood. Using samples along nearshore/offshore transects from five disparate islands in the Pacific Ocean (Oahu, Molokai, Futuna, Aniwa, and Lord Howe) and off California, we show that AAP bacteria, as quantified by the pufM gene biomarker, are most abundant near shore and in areas with high chlorophyll or Synechococcus abundance. These AAP bacterial populations are genetically diverse, with most members belonging to the alpha- or gammaproteobacterial groups and with subclades that are associated with specific environmental variables. The genetic diversity of AAP bacteria is structured along the nearshore/offshore transects in relation to environmental variables, and uncultured pufM gene libraries suggest that nearshore communities are distinct from those offshore. AAP bacterial communities are also genetically distinct between islands, such that the stations that are most distantly separated are the most genetically distinct. Together, these results demonstrate that environmental variables regulate both the abundance and diversity of AAP bacteria but that endemism may also be a contributing factor in structuring these communities.

  3. Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy.

    Science.gov (United States)

    Kurahashi, Toshihiro; Lee, Jaeyong; Nabeshima, Atsunori; Homma, Takujiro; Kang, Eun Sil; Saito, Yuka; Yamada, Sohsuke; Nakayama, Toshiyuki; Yamada, Ken-Ichi; Miyata, Satoshi; Fujii, Junichi

    2016-08-15

    Aldehyde reductase (AKR1A) plays a role in the biosynthesis of ascorbic acid (AsA), and AKR1A-deficient mice produce about 10-15% of the AsA that is produced by wild-type mice. We found that acetaminophen (AAP) hepatotoxicity was aggravated in AKR1A-deficient mice. The pre-administration of AsA in the drinking water markedly ameliorated the AAP hepatotoxicity in the AKR1A-deficient mice. Treatment of the mice with AAP decreased both glutathione and AsA levels in the liver in the early phase after AAP administration, and an AsA deficiency delayed the recovery of the glutathione content in the healing phase. While in cysteine supply systems; a neutral amino acid transporter ASCT1, a cystine transporter xCT, enzymes for the transsulfuration pathway, and autophagy markers, were all elevated in the liver as the result of the AAP treatment, the AsA deficiency suppressed their induction. Thus, AsA appeared to exert a protective effect against AAP hepatotoxicity by ameliorating the supply of cysteine that is available for glutathione synthesis as a whole. Because some drugs produce reactive oxygen species, resulting in the consumption of glutathione during the metabolic process, the intake of sufficient amounts of AsA would be beneficial for protecting against the hepatic damage caused by such drugs. PMID:27288086

  4. Determination of 2-Aminoacetophenone in wine by high-performance thin-layer chromatography-fluorescence detection.

    Science.gov (United States)

    Horlacher, Nora; Schwack, Wolfgang

    2016-02-01

    2-Aminoacetophenone (AAP) is closely correlated with the appearance of the sensory phenomenon of UTA ("untypical aging off-flavor") in wine. AAP analyses are generally performed by gas chromatography and mass selective detection (GC/MS), when AAP is extracted from wines by liquid-liquid, solid-liquid or solid phase microextraction. Here we present a rapid, selective and sensitive method for the determination of AAP in wine by high-performance thin-layer chromatography with fluorescence detection (HPTLC-FLD). As internal standard, 2-amino-4-methoxyacetophenone was used. Liquid-liquid extraction with t-butyl methyl ether was followed by a basic cleanup of the extracts, which were applied onto HPTLC amino plates developed with methylene chloride/toluene (7+3, v/v) as mobile phase. Dipping the dried plate into hexane-paraffin solution enhanced fluorescence that was scanned at 366/>400nm. Limits of detection and quantitation were determined to be 0.1 and 0.3μgL(-1) wine, respectively, while only AAP concentrations >0.5μgL(-1) result in UTA. Recoveries were near 100% for model, white, rosé and red wines. Thus, the HPTLC-FLD method enables the analysis of AAP in wines clearly below the odor thresholds and represents a rapid and convenient screening alternative to existing GC/MS methods.

  5. Efficacy of Artemisia annua polysaccharides as an adjuvant to hepatitis C vaccination.

    Science.gov (United States)

    Bao, L D; Ren, X H; Ma, R L; Wang, Y; Yuan, H W; Lv, H J

    2015-01-01

    The traditional Chinese medicine Artemisia annua can prevent and treat hepatitis following an unclear mechanism. The aim of this study was to evaluate the effects of A. annua polysaccharides (AAP) on hepatitis C virus (HCV). A pcDNA3.1/NS3 expression vector was constructed. Ninety female BALB/c mice were randomly divided into six groups: high-dose AAP (1 mg/mL) + HCV/NS3 plasmid; middle-dose AAP (0.5 mg/mL) + HCV/NS3 plasmid; low-dose AAP (0.1 mg/mL) + HCV/NS3 plasmid; HCV/NS3 plasmid; high-dose AAP (1 mg/mL); normal saline control (N = 15). Except the control group and the high-dose AAP group, other groups were inoculated with 50 μg pcDNA3.1-HCV/NS3 plasmid. Serum antigenic-specific antibody was detected after the last immunization, and the levels of secreted IFN-γ and IL-4 were measured. pcDNA3.1/NS3 plasmid was successfully constructed, and the extracted product contained HCV/NS3 sequence. Compared with single inoculation with HCV/NS3 DNA vaccine, the specific antibody levels induced by middle-dose AAP plus HCV/NS3 DNA vaccine were significantly different in weeks 1, 3 and 5 (P 0.05). The level of serum IFN-γ secretion was significantly higher than that of IL-4 secretion. Compared with the single HCV/NS3 DNA vaccine group, AAP plus HCV/NS3 DNA vaccine groups had significant increased IFN-γ levels (P 0.05). AAP, as the adjuvant of HCV/NS3 DNA vaccine, can widely regulate the humoral immunity and cellular immune function of normal and cyclophosphamide-induced immunocompromised mice. AAP can promote IFN-γ secretion probably by inducing Th1-type cellular immune response. PMID:25966271

  6. Korean Medication Algorithm Project for Bipolar Disorder: third revision

    Directory of Open Access Journals (Sweden)

    Woo YS

    2015-02-01

    Full Text Available Young Sup Woo,1 Jung Goo Lee,2,3 Jong-Hyun Jeong,1 Moon-Doo Kim,4 Inki Sohn,5 Se-Hoon Shim,6 Duk-In Jon,7 Jeong Seok Seo,8 Young-Chul Shin,9 Kyung Joon Min,10 Bo-Hyun Yoon,11 Won-Myong Bahk1 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 2Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, South Korea;3Paik Institute for Clinical Research, Inje Univeristy, Busan, South Korea; 4Department of Psychiatry, Jeju National University Hospital, Jeju, South Korea; 5Department of Psychiatry, Keyo Hospital, Keyo Medical Foundation, Uiwang, South Korea; 6Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Soonchunhyang University, Cheonan, South Korea; 7Department of Psychiatry, Sacred Heart Hospital, Hallym University, Anyang, South Korea; 8Department of Psychiatry, School of Medicine, Konkuk University, Chungju, South Korea; 9Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, South Korea; 10Department of Psychiatry, College of Medicine, Chung-Ang University, Seoul, South Korea; 11Department of Psychiatry, Naju National Hospital, Naju, South Korea Objective: To constitute the third revision of the guidelines for the treatment of bipolar disorder issued by the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP 2014. Methods: A 56-item questionnaire was used to obtain the consensus of experts regarding pharmacological treatment strategies for the various phases of bipolar disorder and for special populations. The review committee included 110 Korean psychiatrists and 38 experts for child and adolescent psychiatry. Of the committee members, 64 general psychiatrists and 23 child and adolescent psychiatrists responded to the survey. Results: The treatment of choice (TOC for euphoric, mixed, and psychotic mania was the combination of a mood stabilizer (MS and an atypical antipsychotic (AAP; the TOC for

  7. Transformation of acetaminophen during water chlorination treatment: kinetics and transformation products identification.

    Science.gov (United States)

    Cao, Fei; Zhang, Mengtao; Yuan, Shoujun; Feng, Jingwei; Wang, Qiquan; Wang, Wei; Hu, Zhenhu

    2016-06-01

    As a high-consumption drug in the world, acetaminophen (AAP) has been widely detected in natural waters and wastewaters. Its reactivity and the transformation products formed during chlorination may greatly threaten the safety of drinking water. The reaction kinetics of AAP during chlorination was investigated in this study. The results showed that the reaction kinetics could be well described with a kinetics model of -d[AAP]/dt = k app[AAP]t (0.63)[Cl2]t (1.37). The values of apparent rate constant (k app) were dependent on reaction temperature, ammonium, and pH. With the increase in reaction temperature from 5.0 ± 1.0 to 40.0 ± 1.0 °C, the removal efficiency of AAP increased from 60 to 100 %. When ammonium was present in the solution at 2.0 mg/L, the transformation of AAP was inhibited due to the rapid formation of chloramines. The maximum of k app was 0.58 × 10(2) M(-1) · min(-1) at pH 9.0, and the minimum was 0.27 M(-1) · min(-1) at pH 11.0. A low mineralization of AAP (about 7.2 %) with chlorination was observed through TOC analysis, implying the formation of plenty of transformation products during chlorination. The main transformation products, hydroquinone and two kinds of chlorinated compounds, monochlorinated acetaminophen and dichlorinated acetaminophen, were detected in gas chromatography-mass spectrometry analysis.

  8. Advanced Avionics and Processor Systems for a Flexible Space Exploration Architecture

    Science.gov (United States)

    Keys, Andrew S.; Adams, James H.; Smith, Leigh M.; Johnson, Michael A.; Cressler, John D.

    2010-01-01

    The Advanced Avionics and Processor Systems (AAPS) project, formerly known as the Radiation Hardened Electronics for Space Environments (RHESE) project, endeavors to develop advanced avionic and processor technologies anticipated to be used by NASA s currently evolving space exploration architectures. The AAPS project is a part of the Exploration Technology Development Program, which funds an entire suite of technologies that are aimed at enabling NASA s ability to explore beyond low earth orbit. NASA s Marshall Space Flight Center (MSFC) manages the AAPS project. AAPS uses a broad-scoped approach to developing avionic and processor systems. Investment areas include advanced electronic designs and technologies capable of providing environmental hardness, reconfigurable computing techniques, software tools for radiation effects assessment, and radiation environment modeling tools. Near-term emphasis within the multiple AAPS tasks focuses on developing prototype components using semiconductor processes and materials (such as Silicon-Germanium (SiGe)) to enhance a device s tolerance to radiation events and low temperature environments. As the SiGe technology will culminate in a delivered prototype this fiscal year, the project emphasis shifts its focus to developing low-power, high efficiency total processor hardening techniques. In addition to processor development, the project endeavors to demonstrate techniques applicable to reconfigurable computing and partially reconfigurable Field Programmable Gate Arrays (FPGAs). This capability enables avionic architectures the ability to develop FPGA-based, radiation tolerant processor boards that can serve in multiple physical locations throughout the spacecraft and perform multiple functions during the course of the mission. The individual tasks that comprise AAPS are diverse, yet united in the common endeavor to develop electronics capable of operating within the harsh environment of space. Specifically, the AAPS tasks for

  9. Diversity of cultivated and metabolically active aerobic anoxygenic phototrophic bacteria along an oligotrophic gradient in the Mediterranean Sea

    Science.gov (United States)

    Jeanthon, C.; Boeuf, D.; Dahan, O.; Le Gall, F.; Garczarek, L.; Bendif, E. M.; Lehours, A.-C.

    2011-07-01

    Aerobic anoxygenic phototrophic (AAP) bacteria play significant roles in the bacterioplankton productivity and biogeochemical cycles of the surface ocean. In this study, we applied both cultivation and mRNA-based molecular methods to explore the diversity of AAP bacteria along an oligotrophic gradient in the Mediterranean Sea in early summer 2008. Colony-forming units obtained on three different agar media were screened for the production of bacteriochlorophyll-a (BChl-a), the light-harvesting pigment of AAP bacteria. BChl-a-containing colonies represented a low part of the cultivable fraction. In total, 54 AAP strains were isolated and the phylogenetic analyses based on their 16S rRNA and pufM genes showed that they were all affiliated to the Alphaproteobacteria. The most frequently isolated strains belonged to Citromicrobium bathyomarinum, and Erythrobacter and Roseovarius species. Most other isolates were related to species not reported to produce BChl-a and/or may represent novel taxa. Direct extraction of RNA from seawater samples enabled the analysis of the expression of pufM, the gene coding for the M subunit of the reaction centre complex of aerobic anoxygenic photosynthesis. Clone libraries of pufM gene transcripts revealed that most phylotypes were highly similar to sequences previously recovered from the Mediterranean Sea and a large majority (~94 %) was affiliated to the Gammaproteobacteria. The most abundantly detected phylotypes occurred in the western and eastern Mediterranean basins. However, some were exclusively detected in the eastern basin, reflecting the highest diversity of pufM transcripts observed in this ultra-oligotrophic region. To our knowledge, this is the first study to document extensively the diversity of AAP isolates and to unveil the active AAP community in an oligotrophic marine environment. By pointing out the discrepancies between culture-based and molecular methods, this study highlights the existing gaps in the understanding

  10. Transformation of acetaminophen during water chlorination treatment: kinetics and transformation products identification.

    Science.gov (United States)

    Cao, Fei; Zhang, Mengtao; Yuan, Shoujun; Feng, Jingwei; Wang, Qiquan; Wang, Wei; Hu, Zhenhu

    2016-06-01

    As a high-consumption drug in the world, acetaminophen (AAP) has been widely detected in natural waters and wastewaters. Its reactivity and the transformation products formed during chlorination may greatly threaten the safety of drinking water. The reaction kinetics of AAP during chlorination was investigated in this study. The results showed that the reaction kinetics could be well described with a kinetics model of -d[AAP]/dt = k app[AAP]t (0.63)[Cl2]t (1.37). The values of apparent rate constant (k app) were dependent on reaction temperature, ammonium, and pH. With the increase in reaction temperature from 5.0 ± 1.0 to 40.0 ± 1.0 °C, the removal efficiency of AAP increased from 60 to 100 %. When ammonium was present in the solution at 2.0 mg/L, the transformation of AAP was inhibited due to the rapid formation of chloramines. The maximum of k app was 0.58 × 10(2) M(-1) · min(-1) at pH 9.0, and the minimum was 0.27 M(-1) · min(-1) at pH 11.0. A low mineralization of AAP (about 7.2 %) with chlorination was observed through TOC analysis, implying the formation of plenty of transformation products during chlorination. The main transformation products, hydroquinone and two kinds of chlorinated compounds, monochlorinated acetaminophen and dichlorinated acetaminophen, were detected in gas chromatography-mass spectrometry analysis. PMID:26983813

  11. Picoplankton Bloom in Global South? A High Fraction of Aerobic Anoxygenic Phototrophic Bacteria in Metagenomes from a Coastal Bay (Arraial do Cabo--Brazil).

    Science.gov (United States)

    Cuadrat, Rafael R C; Ferrera, Isabel; Grossart, Hans-Peter; Dávila, Alberto M R

    2016-02-01

    Marine habitats harbor a great diversity of microorganism from the three domains of life, only a small fraction of which can be cultivated. Metagenomic approaches are increasingly popular for addressing microbial diversity without culture, serving as sensitive and relatively unbiased methods for identifying and cataloging the diversity of nucleic acid sequences derived from organisms in environmental samples. Aerobic anoxygenic phototrophic bacteria (AAP) play important roles in carbon and energy cycling in aquatic systems. In oceans, those bacteria are widely distributed; however, their abundance and importance are still poorly understood. The aim of this study was to estimate abundance and diversity of AAPs in metagenomes from an upwelling affected coastal bay in Arraial do Cabo, Brazil, using in silico screening for the anoxygenic photosynthesis core genes. Metagenomes from the Global Ocean Sample Expedition (GOS) were screened for comparative purposes. AAPs were highly abundant in the free-living bacterial fraction from Arraial do Cabo: 23.88% of total bacterial cells, compared with 15% in the GOS dataset. Of the ten most AAP abundant samples from GOS, eight were collected close to the Equator where solar irradiation is high year-round. We were able to assign most retrieved sequences to phylo-groups, with a particularly high abundance of Roseobacter in Arraial do Cabo samples. The high abundance of AAP in this tropical bay may be related to the upwelling phenomenon and subsequent picoplankton bloom. These results suggest a link between upwelling and light abundance and demonstrate AAP even in oligotrophic tropical and subtropical environments. Longitudinal studies in the Arraial do Cabo region are warranted to understand the dynamics of AAP at different locations and seasons, and the ecological role of these unique bacteria for biogeochemical and energy cycling in the ocean. PMID:26871866

  12. Diversity of the aerobic anoxygenic phototrophy genepufM in Arctic and Antarctic coastal seawaters

    Institute of Scientific and Technical Information of China (English)

    ZENG Yinxin; DONG Peiyan; QIAO Zongyun; ZHENG Tianling

    2016-01-01

    Aerobic anoxygenic phototrophic (AAP) bacteria serve important functions in marine carbon and energy cycling because of their capability to utilize dissolved organic substrates and harvest light energy. AAP bacteria are widely distributed in marine environments, and their diversity has been examined in marine habitats. However, information about AAP bacteria at high latitudes remains insufficient to date. Therefore, this study determined the summer AAP bacterial diversity in Arctic Kongsfjorden and in the Antarctic coastal seawater of King George Island on the basis ofpufM, a gene that encodes a pigment-binding protein subunit of the reaction center complex. FourpufM clone libraries were constructed, and 674 positive clones were obtained from four investigated stations (two in Kongsfjorden and two in the Antarctic Maxwell Bay). Arctic clones were clustered within theAlphaproteobacteria, whereas Antarctic clones were classified into theAlphaproteobacteria and Betaproteobacteria classes.Rhodobacteraceae-likepufM genes dominated in all samples. In addition, sequences closely related topufM encoded on a plasmid inSulfitobacter guttiformis were predominant in both Arctic and Antarctic samples. This result indicates the transpolar or even global distribution ofpufM genes in marine environments. Meanwhile, differences between the Arctic and Antarctic sequences may prove polar endemism. These results indicate the important role ofRhodobacteraceae as AAP bacteria in bipolar coastal waters.

  13. Phylogenetically Diverse Aerobic Anoxygenic Phototrophic Bacteria Isolated from Epilithic Biofilms in Tama River, Japan

    Science.gov (United States)

    Hirose, Setsuko; Matsuura, Katsumi; Haruta, Shin

    2016-01-01

    The diversity of aerobic anoxygenic phototrophic (AAP) bacteria in freshwater environments, particularly in rivers, has not been examined in as much detail as in ocean environments. In the present study, we investigated the phylogenetic and physiological diversities of AAP bacteria in biofilms that developed on submerged stones in a freshwater river using culture methods. The biofilms collected were homogenized and inoculated on solid media and incubated aerobically in the dark. Sixty-eight red-, pink-, yellow-, orange-, or brown-colored colonies were isolated, and, of these, 28 isolates contained the photosynthetic pigment, bacteriochlorophyll (BChl) a. Phylogenetic analyses based on 16S rRNA gene sequences showed that the isolates were classified into 14 groups in 8 operational taxonomic units (OTUs) and distributed in the orders Rhodospirillales, Rhodobacterales, and Sphingomonadales of Alphaproteobacteria and in Betaproteobacteria. Physiological analyses confirmed that none of the representative isolates from any of the groups grew under anaerobic phototrophic conditions. Seven isolates in 4 OTUs showed a 16S rRNA gene sequence identity of 98.0% or less with any established species, suggesting the presence of previously undescribed species of AAP bacteria. Six isolates in 2 other OTUs had the closest relatives, which have not been reported to be AAP bacteria. Physiological comparisons among the isolates revealed differences in preferences for nutrient concentrations, BChl contents, and light-harvesting proteins. These results suggest that diverse and previously unknown AAP bacteria inhabit river biofilms. PMID:27453124

  14. Comparative validity of the Adult Attachment Interview and the Adult Attachment Projective.

    Science.gov (United States)

    Jones-Mason, Karen; Allen, I Elaine; Hamilton, Steve; Weiss, Sandra J

    2015-01-01

    The Adult Attachment Interview (AAI) and the Adult Attachment Projective (AAP) purport to measure the same attachment classifications. The aims of this study were to determine the concurrent validity of the AAI and AAP, and to compare their ability to predict indicators of risk associated with socioeconomic status (SES), depression, and 5-HTTLPR genotype. Results indicated no agreement between AAI and AAP attachment classifications in a sample of late adolescents. As predicted, individuals classified as "unresolved" with regard to loss or trauma were significantly more likely to be of lower SES, have higher levels of depression, and have the 5-HTTLPR "ss" genotype than individuals with secure, preoccupied, or dismissing attachments. These associations, however, were only significant when attachment was classified with the AAI. Results suggest that the AAI and AAP measure different facets of attachment as a result of their unique methodologies and coding criteria. Further research is needed to support their comparability before investigators can assume that the AAP is a valid substitute for the AAI. PMID:26362584

  15. Financing Graduate Medical Education to Meet the Needs of Children and the Future Pediatrician Workforce.

    Science.gov (United States)

    2016-04-01

    The American Academy of Pediatrics (AAP) believes that an appropriately financed graduate medical education (GME) system is critical to ensuring that sufficient numbers of trained pediatricians are available to provide optimal health care to all children. A shortage of pediatric medical subspecialists and pediatric surgical specialists currently exists in the United States, and this shortage is likely to intensify because of the growing numbers of children with chronic health problems and special health care needs. It is equally important to maintain the supply of primary care pediatricians. The AAP, therefore, recommends that children's hospital GME positions funded by the Health Resources and Services Administration be increased to address this escalating demand for pediatric health services. The AAP also recommends that GME funding for pediatric physician training provide full financial support for all years of training necessary to meet program requirements. In addition, all other entities that gain from GME training should participate in its funding in a manner that does not influence curriculum, requirements, or outcomes. Furthermore, the AAP supports funding for training innovations that improve the health of children. Finally, the AAP recommends that all institutional recipients of GME funding allocate these funds directly to the settings where training occurs in a transparent manner.

  16. Influence of selected environmental factors on the abundance of aerobic anoxygenic phototrophs in peat-bog lakes.

    Science.gov (United States)

    Lew, Sylwia; Lew, Marcin; Koblížek, Michal

    2016-07-01

    Aerobic anoxygenic phototrophs (AAPs) are photoheterotrophic prokaryotes that are widespread in many limnic and marine environments. So far, little is known about their distribution in peat-bog lakes. Seventeen peat-bog lakes were sampled during three summer seasons 2009, 2011, and 2012, and the vertical distribution of AAPs was determined by infrared epifluorescence microscopy. The analysis demonstrated that in the surface layers of the studied lakes, AAP abundance ranged from 0.3 to 12.04 × 10(5) cells mL(-1), which represents water column with minimum numbers in the anoxic bottom waters. We have shown that the AAP abundance was significantly positively correlated with the water pH, and the highest proportion of photoheterotrophs was found in peat-bog lakes with a pH between 6.7 and 7.6. Our results demonstrated an influence of water acidity on the abundance of AAPs, which may reflect a fundamental difference in the microbial composition between acidic and pH neutral peat-bog lakes. PMID:27032635

  17. Ssh4, Rcr2 and Rcr1 affect plasma membrane transporter activity in Saccharomyces cerevisiae.

    Science.gov (United States)

    Kota, Jhansi; Melin-Larsson, Monika; Ljungdahl, Per O; Forsberg, Hanna

    2007-04-01

    Nutrient uptake in the yeast Saccharomyces cerevisiae is a highly regulated process. Cells adjust levels of nutrient transporters within the plasma membrane at multiple stages of the secretory and endosomal pathways. In the absence of the ER-membrane-localized chaperone Shr3, amino acid permeases (AAP) inefficiently fold and are largely retained in the ER. Consequently, shr3 null mutants exhibit greatly reduced rates of amino acid uptake due to lower levels of AAPs in their plasma membranes. To further our understanding of mechanisms affecting AAP localization, we identified SSH4 and RCR2 as high-copy suppressors of shr3 null mutations. The overexpression of SSH4, RCR2, or the RCR2 homolog RCR1 increases steady-state AAP levels, whereas the genetic inactivation of these genes reduces steady-state AAP levels. Additionally, the overexpression of any of these suppressor genes exerts a positive effect on phosphate and uracil uptake systems. Ssh4 and Rcr2 primarily localize to structures associated with the vacuole; however, Rcr2 also localizes to endosome-like vesicles. Our findings are consistent with a model in which Ssh4, Rcr2, and presumably Rcr1, function within the endosome-vacuole trafficking pathway, where they affect events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane.

  18. Atypical antipsychotics in the treatment of early-onset schizophrenia

    Directory of Open Access Journals (Sweden)

    Hrdlicka M

    2015-04-01

    Full Text Available Michal Hrdlicka, Iva Dudova Department of Child Psychiatry, Charles University Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic Abstract: Atypical antipsychotics (AAPs have been successfully used in early-onset schizophrenia (EOS. This review summarizes the randomized, double-blind, controlled studies of AAPs in EOS, including clozapine, risperidone, olanzapine, aripiprazole, paliperidone, quetiapine, and ziprasidone. No significant differences in efficacy between AAPs were found, with the exception of clozapine and ziprasidone. Clozapine demonstrated superior efficacy in treatment-resistant patients with EOS, whereas ziprasidone failed to demonstrate efficacy in the treatment of EOS. Our review also focuses on the onset of action and weight gain associated with AAPs. The data on onset of action of AAPs in pediatric psychiatry are scanty and inconsistent. Olanzapine appears to cause the most significant weight gain in patients with EOS, while ziprasidone and aripiprazole seem to cause the least. Keywords: early-onset schizophrenia, atypical antipsychotics, efficacy, onset of action, weight gain

  19. Novel Spectrophotometric Method for Determination of Macro-paracetamol via Reaction with Bromine

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    The reaction between Br2 and paracetamol(p-AAP) leads to the formation of a coloured product, which can be used for spectrophotometric determination of the p-AAP content in its pure form and in different pharmaceutical preparations with p-AAP. The stoichiometric composition of the reaction was found to be n(p-AAP)∶n(bromine)=1∶3. The effects of pH and time on the spectra of p-AAP-bromine redox reaction product were studied. The interference of different additives on the measured spectra of the obtained product was also studied. The results obtained by the present method were compared with those obtained by the standard method. The F- and t- test values were calculated for both of the applied procedures and they met a confidence level of 99%. The proposed procedure actually needs no separation of these drugs from their sources before analysis and was unaffected by interference of other phenolic compounds. The proposed method is simpler and faster than the repoeted ones.

  20. Changes in Phosphorylation of Connexin43 in Rats during Acute Myocardial Hypoxia and Effects of Antiarrhythmic Peptide on the Phosphorylation

    Institute of Scientific and Technical Information of China (English)

    WANG Rong; ZHANG Cuntai; RUAN Yanfei; LIU Nian; WANG Lin

    2007-01-01

    In order to confirm the hypothesis that during acute hypoxia, the antiarrhythmic peptide (AAP10) could improve conductance by changing the phosphorylation state of connexin43 (Cx43),isolated perfused rat hearts were randomly divided into three groups: control, hypoxia and AAP10 (n=9 in each group). The change in Cx43 phosphorylation was tested by Western-blot; the distribution of Cx43 was observed by confocal immunofluorescence microscopy. Western-blot analysis revealed that the expression of total Cx43 protein was significantly decreased during acute hypoxia,while nonphosphorylated Cx43 (NP-Cx43) was unchanged. AAP10 could increase the expression of total Cx43 protein, but had no effects on the NP-Cx43 protein. Immunofluorescence study showed that during acute hypoxia, both total Cx43 and NP-Cx43 proteins were greatly decreased, while AAP10 only increased the expression of total Cx43 protein, but had no effect of the NP-Cx43 protein expression. These findings suggested that the decrease of intercellular communication may be associated with the reduction of phosphorylated Cx43 (p-Cx43) and translocation of NP-Cx43 from the surface of gap junction into intracellular pools during acute hypoxia. AAP10 can improve intercelluar communication by enhancing phosphorylation of Cx43.

  1. Effects of switching to aripiprazole from current atypical antipsychotics on subsyndromal symptoms and tolerability in patients with bipolar disorder.

    Science.gov (United States)

    Woo, Young Sup; Bahk, Won-Myong; Park, Young-Min; Chung, Sangkeun; Yoon, Bo-Hyun; Won, Seunghee; Lee, Jeong Goo; Lee, Hwang-Bin; Kim, Won; Jeong, Jong-Hyun; Lee, Kwanghun; Kim, Moon-Doo

    2016-09-01

    We evaluated the effectiveness of aripiprazole among bipolar patients who had switched to this medication as a result of difficulty maintaining on their prestudy atypical antipsychotics (AAPs) because of subsyndromal mood symptoms or intolerance. This study included 77 bipolar patients who were in syndromal remission with an AAP as monotherapy or with an AAP combined with a mood stabilizer(s) who needed to switch from their present AAP because of subsyndromal symptoms or intolerance. At 24 weeks after switching to aripiprazole, the remission rates on the Montgomery-Åsberg Depression Rating Scale (MADRS) and on both the MADRS and the Young Mania Rating Scale were increased significantly in the full sample and in the inefficacy subgroup. In the inefficacy subgroup, the MADRS score change was significant during the 24 weeks of study. Total cholesterol and prolactin decreased significantly after switching to aripiprazole. The proportion of patients who had abnormal values for central obesity and hypercholesterolemia decreased significantly from baseline to week 24. These findings suggest that a change from the current AAP to aripiprazole was associated with improvement in subsyndromal mood symptoms and several lipid/metabolic or safety profile parameters in patients with bipolar disorder with tolerability concerns or subsyndromal mood symptoms. PMID:27487259

  2. Fabrication of multiwalled carbon nanotube-surfactant modified sensor for the direct determination of toxic drug 4-aminoantipyrine☆

    Institute of Scientific and Technical Information of China (English)

    Jayant I. Gowda; Arunkumar T. Buddanavar; Sharanappa T. Nandibewoor

    2015-01-01

    A multi-walled carbon nanotube (MWCNT)-cetyltrimethylammonium bromide (CTAB) surfactant composite modified glassy carbon electrode (GCE) was developed as a novel system for the determination of 4-aminoantipyrine(AAP). The oxidation process was irreversible over the pH range studied and exhibited a diffusion controlled behavior. All experimental parameters were optimized. The combination of MWCNT-CTAB endows the biosensor with large surface area, good biological compatibility, electricity and stability, high selectivity and sensitivity. MWCNT-CTAB /GCE electrode gave a linear response for AAP from 5.0 × 10-9 to 4.0 × 10-8 M with a detection limit of 1.63 × 10-10 M. The modified electrode showed good selectivity against interfering species and also exhibited good reproducibility. The present electrochemical sensor based on the MWCNT-CTAB/GCE electrode was applied to the determination of AAP in real samples.

  3. Lawrence Berkeley Laboratory Affirmative Action Program. Revised

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    The Lawrence Berkeley Laboratory`s Affirmative Action Program (AAP) serves as a working document that describes current policies, practices, and results in the area of affirmative action. It represents the Laboratory`s framework for an affirmative approach to increasing the representation of people of color and women in segments of our work force where they have been underrepresented and taking action to increase the employment of persons with disabilities and special disabled and Vietnam era veterans. The AAP describes the hierarchy of responsibility for Laboratory affirmative action, the mechanisms that exist for full Laboratory participation in the AAP, the policies and procedures governing recruitment at all levels, the Laboratory`s plan for monitoring, reporting, and evaluating affirmative action progress, and a description of special affirmative action programs and plans the Laboratory has used and will use in its efforts to increase the representation and retention of groups historically underrepresented in our work force.

  4. Solar energy applications at Army ammunition plants

    Science.gov (United States)

    Lowry, A. P.; Moy, S. M.

    1982-06-01

    The Army Ammunition Plants use significant quantities of fossil fuels. To reduce dependence on these scarce, costly, and non-renewable fuels, a study was conducted to investigate potential solar energy applications at the AAPs. Solar energy is a low-level energy source which is best applied to low temperature applications. It can be used at the AAPs to preheat boiler feedwater, provide hot air for dry-houses, provide domestic hot water and heat for administration buildings, and provide hot water for manufacturing processes such as metal cleaning, phosphating, and X-ray film processing. Use of the flat plate collectors, evacuated tube collectors, or solar ponds with the possible addition of a heat pump, offers reasonably economical means of applying solar technology to AAP needs.

  5. Structural, thermal, morphological and biological studies of proton-transfer complexes formed from 4-aminoantipyrine with quinol and picric acid

    Science.gov (United States)

    Adam, Abdel Majid A.

    2013-03-01

    4-Aminoantipyrine (4AAP) is widely used in the pharmaceutical industry, biochemical experiments and environmental monitoring. However, residual amounts of 4AAP in the environment may pose a threat to human health. To provide basic data that can be used to extract or eliminate 4AAP from the environment, the proton-transfer complexes of 4AAP with quinol (QL) and picric acid (PA) were synthesized and spectroscopically investigated. The interactions afforded two new proton-transfer salts named 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-aminium-4-hydroxyphenolate and 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-aminium-2,4,6-trinitrophenolate for QL and PA, respectively, via a 1:1 stoichiometry. Elemental analysis (CHN), electronic absorption, spectrophotometric titration, IR, Raman, 1H NMR and X-ray diffraction were used to characterize the new products. The thermal stability of the synthesized CT complexes was investigated using thermogravimetric (TG) analyses, and the morphology and particle size of these complexes were obtained from scanning electron microscopy (SEM). It was found that PA and 4AAP immediately formed a yellow precipitate with a remarkable sponge-like morphology and good thermal stability up to 180 °C. Finally, the biological activities of the newly synthesized CT complexes were tested for their antibacterial and antifungal activities. The results indicated that the [(4AAP)(QL)] complex exhibited strong antimicrobial activities against various bacterial and fungal strains compared with standard drugs.

  6. Active appearance pyramids for object parametrisation and fitting.

    Science.gov (United States)

    Zhang, Qiang; Bhalerao, Abhir; Dickenson, Edward; Hutchinson, Charles

    2016-08-01

    Object class representation is one of the key problems in various medical image analysis tasks. We propose a part-based parametric appearance model we refer to as an Active Appearance Pyramid (AAP). The parts are delineated by multi-scale Local Feature Pyramids (LFPs) for superior spatial specificity and distinctiveness. An AAP models the variability within a population with local translations of multi-scale parts and linear appearance variations of the assembly of the parts. It can fit and represent new instances by adjusting the shape and appearance parameters. The fitting process uses a two-step iterative strategy: local landmark searching followed by shape regularisation. We present a simultaneous local feature searching and appearance fitting algorithm based on the weighted Lucas and Kanade method. A shape regulariser is derived to calculate the maximum likelihood shape with respect to the prior and multiple landmark candidates from multi-scale LFPs, with a compact closed-form solution. We apply the 2D AAP on the modelling of variability in patients with lumbar spinal stenosis (LSS) and validate its performance on 200 studies consisting of routine axial and sagittal MRI scans. Intervertebral sagittal and parasagittal cross-sections are typically used for the diagnosis of LSS, we therefore build three AAPs on L3/4, L4/5 and L5/S1 axial cross-sections and three on parasagittal slices. Experiments show significant improvement in convergence range, robustness to local minima and segmentation precision compared with Constrained Local Models (CLMs), Active Shape Models (ASMs) and Active Appearance Models (AAMs), as well as superior performance in appearance reconstruction compared with AAMs. We also validate the performance on 3D CT volumes of hip joints from 38 studies. Compared to AAMs, AAPs achieve a higher segmentation and reconstruction precision. Moreover, AAPs have a significant improvement in efficiency, consuming about half the memory and less than 10% of

  7. Dicty_cDB: Contig-U07086-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available al-Ocean-Sampling_GS-31-01-01-1... 44 5.5 1 ( DY272854 ) IC0AAA32BC06RM1 CitNFL Citrus clementina cDNA 5',...... 44 5.5 1 ( DY271159 ) KN0AAP9YA15FM1 Fruit-TF Citrus clementina cDNA 5'... 44 5.5 1 ( DY259793 ) KN0AAP10Y...D11FM1 Fruit-TF Citrus clementina cDNA 5... 44 5.5 1 ( CV710938 ) UCRPT01_0015C02

  8. Effects of antiarrhythmic peptide 10 on acute ventricular arrhythmia

    Institute of Scientific and Technical Information of China (English)

    Bing Sun; Jin-Fa Jiang; Cui-Mei Zhao; Chao-Hui Hu

    2015-01-01

    Objective:To observe the effects antiarrhythmic peptide 10 (AAP10) aon acute ventricular arrhythmia and the phosphorylation state of ischemic myocardium connexin.Methods:Acute total ischemia and partial ischemia models were established by ceasing perfusion and ligating the left anterior descending coronary artery in SD rats. The effects of AAP10 (1 mg/L) on the incidence rate of ischemia-induced ventricular arrhythmia were observed. The ischemic myocardium was sampled to detect total-Cx43 and NP-Cx43 by immunofluorescent staining and western blotting. the total-Cx43 expression was detected through image analysis system by semi-quantitative analysis.Results: AAP10 could significantly decrease the incidence of ischemia-induced ventricular tachycardia and ventricular fibrillation. During ischemic stage, total ischemia (TI) and AAP10 total ischemia (ATI) groups were compared with partial ischemia (PI) and AAP10 partial ischemia (API) groups. The rates of incidence for arrhythmia in the ATI and API groups (10% and 0%) were lower than those in the TI and PI groups (60% and 45%). The difference between the two groups was statistically significant (P=0.019, P=0.020). The semi-quantitative analysis results of the ischemic myocardium showed that the total-Cx43 protein expression distribution areas for TI, ATI, PI and API groups were significantly decreased compared with the control group. On the other hand, the NP-Cx43 distribution areas of TI, ATI, PI and API groups were significantly increased compared with the control group (P>0.05). AAP10 could increase the total-Cx43 expression in the ischemic area and decrease the NP-Cx43 expression. Western blot results were consistent with the results of immunofluorescence staining.Conclusions:AAP10 can significantly decrease the rate of incidence of acute ischemia-induced ventricular tachycardia and ventricular fibrillation. Acute ischemic ventricular arrhythmias may have a relationship with the decreased phosphorylation of Cx43

  9. Endorsing safe infant sleep: a call to action.

    Science.gov (United States)

    Hitchcock, Sharon

    2012-01-01

    The American Academy of Pediatrics (AAP) safe sleep recommendations are considered best practice and are effective in preventing sudden infant death syndrome (SIDS). Yet studies have found that nurses' practice in newborn nurseries and neonatal intensive care units is often inconsistent with safe sleep recommendations. Such inconsistencies cause confusion and hinder SIDS prevention efforts. In 2011, the AAP added significant content to its 2005 safe sleep recommendations and neonatal nurses are now being asked to endorse the recommendations from birth. This article reviews the recommendations, examines barriers and controversies and offers suggestions for how an organization might initiate change and move toward a unified endorsement of safe sleep strategies. PMID:23067283

  10. Advanced Avionics and Processor Systems for Space and Lunar Exploration

    Science.gov (United States)

    Keys, Andrew S.; Adams, James H.; Ray, Robert E.; Johnson, Michael A.; Cressler, John D.

    2009-01-01

    NASA's newly named Advanced Avionics and Processor Systems (AAPS) project, formerly known as the Radiation Hardened Electronics for Space Environments (RHESE) project, endeavors to mature and develop the avionic and processor technologies required to fulfill NASA's goals for future space and lunar exploration. Over the past year, multiple advancements have been made within each of the individual AAPS technology development tasks that will facilitate the success of the Constellation program elements. This paper provides a brief review of the project's recent technology advancements, discusses their application to Constellation projects, and addresses the project's plans for the coming year.

  11. Efficiency and patient experience with propofol vsconventional sedation: A prospective study

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    AIM To determine whether anaesthesiologistadministeredsedation with propofol (AAP) or endoscopist-administered conscious sedation (EAC) withfentanyl/midazolam shortens colonoscopy duration/totalroom time.METHODS: This is a prospective, non-randomized,comparative study that enrolled patients greater than18 years of age undergoing colonoscopy in a singleCanadian academic outpatient endoscopy unit over athree-month consecutive period. Colonoscopies in thisunit are performed both with AAP and EAC. Patientdemographics, procedure-related data and adverseevents were documented. Additionally, the level ofprocedure difficulty, and whether a staff endoscopist,trainee with assistance, or independent trainee, performedthe procedure were documented. A validatedmodified 4-question, 5-point Likert scale telephonesurvey was used to assess patient satisfaction withcolonoscopy. The telephone patient satisfaction surveywas conducted 24-72 h following the procedure.RESULTS: Two hundred and thirty patients were enrolled during the study period with 126 patients inthe AAP group and 104 patients in the EAC group.Mean procedure time was 18.3 ± 10.1 min in theAAP group and 14.7 ± 7.1 min in the EAC group (P =0.002). Mean total room time was 36.8 ± 13.7 with AAPand 30.1 ± 11 min with EAC (p 〈 0.001). Multivariateanalysis revealed the use of AAP (P = 0.002), residentparticipation (p 〈 0.001), diagnostic interventions (p= 0.033), therapeutic interventions (p 〈 0.001), lowerbody mass index (p = 0.008) and American Society ofAnaesthesiologist class (p = 0.016), to be predictorsof longer total room time. Patient age and genderwere not significant predictors. After excluding cases inwhich trainees were involved, there was no significantdifference in procedure time between the two groups (p= 0.941), however total room time was still prolongedin the AAP group (p = 0.019). The amount of painexperienced was lower with AAP (p = 0.02

  12. 75 FR 47819 - Workshop on Optimizing Clinical Trial Design for the Development of Pediatric Cardiovascular Devices

    Science.gov (United States)

    2010-08-09

    ... support from the American Academy of Pediatrics (AAP), the American College of Cardiology (ACC), and the... developing devices for the pediatric cardiology market. The information gathered in this and future workshops will help to develop future guidance on optimal designs for pediatric cardiology device trials....

  13. Eesti paviljon "Koda" = Estonian pavilion "Koda"

    Index Scriptorium Estoniae

    2015-01-01

    Eesti paviljon "Koda" Hollandi maailmanäitusel "Floriade". Arhitektuurivõistlus 2011. Arhitektid Joel Kopli, Koit Ojaliiv (Kuu Arhitektid), konstruktorid Alar Hammer, Marek Suursalu (Projekt 363). Lauad Kristel Jakobson (Haka Disain), toolid Aap Piho (Maast Furniture), valgustid Margus Triibmann (Keha3)

  14. 40 CFR Appendix A to Part 419 - Processes Included in the Determination of BAT Effluent Limitations for Total Chromium...

    Science.gov (United States)

    2010-07-01

    ..., and Phenolic Compounds (4AAP) Crude Processes 1. Atmospheric Crude Distillation 2. Crude Desalting 3. Vacuum Crude Distillation Cracking and Coking Processes 4. Visbreaking 5. Thermal Cracking 6. Fluid.... Lube Vac Twr, Oil Fractionation, Batch Still (Naphtha Strip), Bright Stock Treating 26. Centrifuge...

  15. Vitamin D in Health and Disease in Adolescents: When to Screen, Whom to Treat, and How to Treat.

    Science.gov (United States)

    Golden, Neville H; Carey, Dennis E

    2016-01-01

    The existing guidelines on screening and treatment are confusing because different guidelines target different populations. The IOM and AAP guidelines target generally healthy populations, whereas the Endocrine Society and other subspecialty guidelines target individuals with specific medical conditions associated with increased bone fragility. These distinctions have not always been well articulated. For healthy adolescents, the AAP does not recommend universal screening or screening of obese or dark-skinned individuals. Increased dietary intake of vitamin D is recommended, and vitamin D supplementation can be considered if the RDA cannot be met. For adolescents with chronic medical illnesses associated with increased fracture risk, screening for vitamin D deficiency should be performed by obtaining a serum 25-OHD level. Those found to be deficient (25-OHD level vitamin D2 or vitamin D3 higher than the daily requirement (as discussed in the section on vitamin D and chronic disease), followed by a maintenance dose. A repeat 25-OHD level should be obtained after the therapeutic course is completed. Some experts advocate for achievement of 25-OHD levels greater than 30 ng/mL in conditions associated with increased bone fragility, and several pediatric subspecialty organizations have made recommendations specific to the diseases they treat. In such instances, the recommendations of the pediatric subspecialty organizations should take precedence over the AAP recommendations for adolescents with chronic illnesses associated with increased bone fragility because the AAP recommendations were primarily targeted at a healthy population.

  16. A Novel Approach to Critical Congenital Heart Disease (CCHD Screening at Moderate Altitude

    Directory of Open Access Journals (Sweden)

    Erin Lueth

    2016-07-01

    Full Text Available The American Academy of Pediatrics (AAP has endorsed Critical Congenital Heart Disease (CCHD screening using pulse oximetry nationwide, but, however, acknowledges that altitude may impact failure rates and alternative algorithms may be required at high altitudes. We therefore evaluated a modified screening protocol at an altitude of 6200 feet with the hypothesis that modifications could decrease failure rates. We evaluated 2001 well, newborn infants ≥35 weeks gestation using a modified protocol, which included a lower saturation cutoff for the first screen (85% instead of the AAP recommended 90% and an oxygen hood intervention between the first two screens. Using our modified screening algorithm, we found a 0.3% failure rate, which was similar to the 0.2% sea-level rate and statistically different from the 1.1% rate identified in a recent study at similar altitude. Had the AAP protocol been used, the failure rate would have increased to 0.8%, which is similar to prior reports near this altitude. Echocardiograms were performed on failing newborns with no CCHD identified. A Birth Defects Registry Database review demonstrated one newborn with CCHD was missed after meeting AAP passing criteria. Overall, this study demonstrates that an alternative algorithm can be implemented at moderate altitude with decreased failure rate and comparable false negative rate.

  17. NCBI nr-aa BLAST: CBRC-CINT-01-0121 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CINT-01-0121 ref|NP_999827.1| polycystic kidney disease protein 2 [Strongyloce...ntrotus purpuratus] gb|AAP35006.1| polycystic kidney disease protein 2 [Strongylocentrotus purpuratus] NP_999827.1 0.26 22% ...

  18. NCBI nr-aa BLAST: CBRC-XTRO-01-2527 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-2527 ref|YP_003772.1| myristylated membrane protein [Ambystoma tigrinu...m virus] gb|AAP33178.1| myristylated membrane protein [Ambystoma tigrinum stebbensi virus] YP_003772.1 0.035 56% ...

  19. NCBI nr-aa BLAST: CBRC-XTRO-01-3773 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-3773 ref|YP_003772.1| myristylated membrane protein [Ambystoma tigrinu...m virus] gb|AAP33178.1| myristylated membrane protein [Ambystoma tigrinum stebbensi virus] YP_003772.1 0.13 56% ...

  20. NCBI nr-aa BLAST: CBRC-XTRO-01-0714 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-0714 ref|YP_003772.1| myristylated membrane protein [Ambystoma tigrinu...m virus] gb|AAP33178.1| myristylated membrane protein [Ambystoma tigrinum stebbensi virus] YP_003772.1 0.035 56% ...

  1. NCBI nr-aa BLAST: CBRC-XTRO-01-0480 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-0480 ref|YP_003772.1| myristylated membrane protein [Ambystoma tigrinu...m virus] gb|AAP33178.1| myristylated membrane protein [Ambystoma tigrinum stebbensi virus] YP_003772.1 0.045 56% ...

  2. NCBI nr-aa BLAST: CBRC-XTRO-01-3553 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-3553 ref|YP_003772.1| myristylated membrane protein [Ambystoma tigrinu...m virus] gb|AAP33178.1| myristylated membrane protein [Ambystoma tigrinum stebbensi virus] YP_003772.1 2.4 53% ...

  3. NCBI nr-aa BLAST: CBRC-XTRO-01-0562 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-0562 ref|YP_003772.1| myristylated membrane protein [Ambystoma tigrinu...m virus] gb|AAP33178.1| myristylated membrane protein [Ambystoma tigrinum stebbensi virus] YP_003772.1 0.045 56% ...

  4. Osteoclastogenesis is influenced by modulation of gap junctional communication with antiarrhythmic peptides.

    Science.gov (United States)

    Kylmäoja, Elina; Kokkonen, Hanna; Kauppinen, Kyösti; Hussar, Piret; Sato, Tetsuji; Haugan, Ketil; Larsen, Bjarne Due; Tuukkanen, Juha

    2013-03-01

    Osteoclasts are formed by the fusion of mononuclear precursor cells of the monocyte-macrophage lineage. Among several putative mechanisms, gap-junctional intercellular communication (GJC) has been proposed to have a role in osteoclast fusion and bone resorption. We examined the role of GJC in osteoclastogenesis and in vitro bone resorption with mouse bone marrow hematopoietic stem cells and RAW 264.7 cells. Blocking of gap junctions with 18-α-glycyrrhetinic acid (18GA) led to inhibition of osteoclastogenesis and in vitro bone resorption. Similarly, the GJC inhibitor GAP27 inhibited osteoclast formation. GJC modulation with the antiarrhythmic peptides (AAPs) led to increased amounts of multinuclear RAW 264.7 osteoclasts as well as increased number of nuclei per multinuclear cell. In the culture of bone marrow hematopoietic stem cells in the presence of bone marrow stromal cells AAP reduced the number of osteoclasts, and coculture of MC3T3-E1 preosteoblasts with RAW 264.7 macrophages prevented the action of AAPs to promote osteoclastogenesis. The present data indicate that AAPs modulate the fusion of the pure culture of cells of the monocyte-macrophage lineage. However, the fusion is influenced by GJC in cells of the osteoblast lineage.

  5. Phosphorus forms and bioavailability of lake sediments in the middle and lower reaches of Yangtze River

    Institute of Scientific and Technical Information of China (English)

    ZHU; Guangwei; QIN; Boqiang; ZHANG; Lu

    2006-01-01

    Forms of phosphorus in sediments from 25 lakes in the middle and lower reaches of Yangtze River were analyzed by the sequential extraction procedure. Contents and spatial distrubution of algal available phosphorus (AAP) in sediments of Lake Taihu, the third largest freshwater lake of China, were also studied. Relationships between phosphorus forms in sediment and macrophytes coverage in sample sites, as well as phosphorus forms in sediments and chlorophyal contents in lake water were discussed. Exchangeable form of phosphorus (Ex-P) in surface sediments was significantly positive correlative to total phosphorus (TP), dissolved total phosphorus (DTP) and soluble reactive phosphorus (SRP) contents in the lake water. Bioavailable phosphorus (Bio-P) contents in sediments from macrophytes dominant sites were significantly lower than that in no macrophyte sites. In Lake Taihu, Ex-P content in top 3 cm sediment was highest.However, content of ferric fraction phosphorus (Fe-P) was highest in 4-10 cm. Bioavalilble phosphorus (Bio-P) contents in surface sediments positively correlated to Chlorophyll a contents in water of Lake Taihu with significant difference. Therefore, contents of Bio-P and AAP could be acted as the indicators of risks of internal release of phosphorus in the shallow lakes. It was estimated that there were 268.6 ton AAP in top 1 cm sediments in Lake Taihu. Sediment suspension caused by strong wind-induced wave disturbance could carry plenty of AAP into water in large shallow lakes like Lake Taihu.

  6. Toddler Growth and Development

    Science.gov (United States)

    ... in Action Medical Editor & Editorial Advisory Board Sponsors Sponsorship Opporunities Spread the Word Shop AAP Find a ... Body Your child is advancing from infancy toward and into the preschool years. During this time, his or her physical growth and motor development will slow, but you can expect to see ...

  7. Bemisia tabaci (Homoptera: Aleyrodidae) and Indian cassava mosaic virus transmission

    Science.gov (United States)

    Bemisia tabaci (Gennadius) adults from colonies reared on cassava or sweet potato plants were studied to determine their ability to transmit Indian cassava mosaic virus (ICMV) (Geminiviridae: Begomovirus) from cassava to cassava. Virus acquisition access (feeding) periods (AAP) of 48 h on ICMV-infec...

  8. Enhancing pediatric workforce diversity and providing culturally effective pediatric care: implications for practice, education, and policy making.

    Science.gov (United States)

    2013-10-01

    This policy statement serves to combine and update 2 previously independent but overlapping statements from the American Academy of Pediatrics (AAP) on culturally effective health care (CEHC) and workforce diversity. The AAP has long recognized that with the ever-increasing diversity of the pediatric population in the United States, the health of all children depends on the ability of all pediatricians to practice culturally effective care. CEHC can be defined as the delivery of care within the context of appropriate physician knowledge, understanding, and appreciation of all cultural distinctions, leading to optimal health outcomes. The AAP believes that CEHC is a critical social value and that the knowledge and skills necessary for providing CEHC can be taught and acquired through focused curricula across the spectrum of lifelong learning. This statement also addresses workforce diversity, health disparities, and affirmative action. The discussion of diversity is broadened to include not only race, ethnicity, and language but also cultural attributes such as gender, religious beliefs, sexual orientation, and disability, which may affect the quality of health care. The AAP believes that efforts must be supported through health policy and advocacy initiatives to promote the delivery of CEHC and to overcome educational, organizational, and other barriers to improving workforce diversity. PMID:24081998

  9. Grr1p is required for transcriptional induction of amino acid permease genes and proper transcriptional regulation of genes in carbon metabolism of Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Eckert-Boulet, Nadine; Regenberg, Birgitte; Nielsen, Jens

    2005-01-01

    and a grr1 Delta strain and adding citrulline in the exponential phase. Whole-genome transcription analyses were performed on samples from each cultivation, both immediately before and 30 min after citrulline addition. Transcriptional induction of the AAP genes AGP1, BAP2, BAP3, DIP5, GNP1 and TAT1 is fully...

  10. Prevalence of Virulence-Related Determinants in Clinical Isolates of Staphylococcus epidermidis

    Science.gov (United States)

    Najar Peerayeh, Shahin; Jazayeri Moghadas, Ali; Behmanesh, Mehrdad

    2016-01-01

    Background Staphylococcus epidermidis, a member of the human flora, is recognized as an opportunistic pathogen and cause of nosocomial infections. Staphylococcus epidermidis surface components are able to establish bacteria on the host surface, and cause infection. Objectives The frequency of icaA, IS256, aap, fbe and bhp in clinical isolates of S. epidermidis were investigated in this study. Materials and Methods Fifty-nine S. epidermidis isolates were collected from blood (50), wound (1), urine (4) and tracheal (4) samples (Tehran, Iran). Staphylococcus epidermidis isolates were identified with conventional bacteriological tests. Virulence-associated genes were detected by specific polymerase chain reactions (PCRs). Results Of the 59 S. epidermidis, fbe was found in 89.8%, while aap and bhp were observed in 64.4% and 15.3% of the samples, respectively. Coexistence of aap and fbe was found in 32 isolates, while coexistence of bhp and fbe was observed in five isolates. Two isolates were negative for the investigated genes. Conclusions Prevalence of fbe and aap was significantly different from similar studies, yet frequency of bhp was in accordance with other studies. Prevalence of icaA and IS256 was not significantly different from some studies while a significant difference was observed when results were compared with some other studies. PMID:27800129

  11. NCBI nr-aa BLAST: CBRC-XTRO-01-0066 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-0066 ref|NP_942999.1| putative entry exclusion protein [Ralstonia eutr...opha H16] gb|AAP86113.1| putative entry exclusion protein [Ralstonia eutropha] NP_942999.1 3e-05 27% ...

  12. For Kids Playing Pokemon Go, Catch These Safety Tips

    Science.gov (United States)

    ... an "augmented reality" game. That means it's a game that is partly virtual and partly based in reality. Players need to go out into the real world. "You can't just play this game from your living room," AAP spokeswoman Dr. Elizabeth ...

  13. Influence of the surface structure on the filtration performance of UV-modified PES membranes

    DEFF Research Database (Denmark)

    Kæselev, Bozena Alicja; Kingshott, P.; Jonsson, Gunnar Eigil

    2002-01-01

    Poly (ether sulfone) (PES) 50 kDa membranes were surface modified by irradiation with UV light (254 nm) in the presence of N-vinyl-2-pyrrolidine (NVP), 2-acrylamidoglycolic acid monohydrate (AAG) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AAP). The surfaces of the modified membranes were...

  14. Rundum artist-run space and its elusive form / Hanna Laura Kaljo, Mari-Leen Kiipli, Kulla Laas ... [jt.

    Index Scriptorium Estoniae

    2015-01-01

    Rundum on 2013. a septembris Tallinnas loodud liikuv loominguline platvorm, mille eesmärgiks on suhestuda erinevate kohtadega, reageerida tühikutele Eesti loomemaastikus ning uurida sealjuures ka omaalgatuslike praktikate võimalikkust kohalikus kontekstis. Vestlusringis Rundumi algatajad Mari-Leen Kiipli, Kulla Laas, Aap Tepper, Mari Volens, Kristina Õllek

  15. NCBI nr-aa BLAST: CBRC-ATHA-02-0010 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ATHA-02-0010 ref|NP_179704.2| unknown protein [Arabidopsis thaliana] gb|AAM981...39.1| unknown protein [Arabidopsis thaliana] gb|AAP37861.1| At2g21080 [Arabidopsis thaliana] NP_179704.2 0.0 100% ...

  16. Recent evidence and potential mechanisms underlying weight gain and insulin resistance due to atypical antipsychotics

    Directory of Open Access Journals (Sweden)

    Ana Maria Volpato

    2013-09-01

    Full Text Available Objective: Atypical antipsychotics (AAPs promote obesity and insulin resistance. In this regard, the main objective of this study was to present potential mechanisms and evidence concerning side effects of atypical antipsychotics in humans and rodents. Method: A systematic review of the literature was performed using the MEDLINE database. We checked the references of selected articles, review articles, and books on the subject. Results: This review provides consistent results concerning the side effects of olanzapine (OL and clozapine (CLZ, whereas we found conflicting results related to other AAPs. Most studies involving humans describe the effects on body weight, adiposity, lipid profile, and blood glucose levels. However, it seems difficult to identify an animal model replicating the wide range of changes observed in humans. Animal lineage, route of administration, dose, and duration of treatment should be carefully chosen for the replication of the findings in humans. Conclusions: Patients undergoing treatment with AAPs are at higher risk of developing adverse metabolic changes. This increased risk must be taken into account when making decisions about treatment. The influence of AAPs on multiple systems is certainly the cause of such effects. Specifically, muscarinic and histaminergic pathways seem to play important roles.

  17. Simultaneous Detection of Phenols and Anilines in Oilfield Waste Water

    Institute of Scientific and Technical Information of China (English)

    Yuan Cunguang; Feng Chengwu

    1996-01-01

    @@ Phenols and aromatic anilines are monitored in many countries , because both of them pollute environment seriously. The methods of 4-AAP(4-Aminoantipyrine)photometric detection of volatile phenols and naphthalene -ethyl-diamine-azo photometric detection of anilines are recommended by the National Environmental Protection Bureau, China (NEPBC).

  18. Surveying Turkish High School and University Students' Attitudes and Approaches to Physics Problem Solving

    Science.gov (United States)

    Balta, Nuri; Mason, Andrew J.; Singh, Chandralekha

    2016-01-01

    Students' attitudes and approaches to physics problem solving can impact how well they learn physics and how successful they are in solving physics problems. Prior research in the U.S. using a validated Attitude and Approaches to Problem Solving (AAPS) survey suggests that there are major differences between students in introductory physics and…

  19. NCBI nr-aa BLAST: CBRC-TTRU-01-0629 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-0629 sp|Q863H8|DUFFY_BOSIN RecName: Full=Duffy antigen/chemokine recep...tor; AltName: CD_antigen=CD234 gb|AAP31577.1| duffy antigen/chemokine receptor [Bos indicus] Q863H8 1e-148 79% ...

  20. NCBI nr-aa BLAST: CBRC-VPAC-01-1150 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-VPAC-01-1150 sp|Q863H8|DUFFY_BOSIN RecName: Full=Duffy antigen/chemokine recep...tor; AltName: CD_antigen=CD234 gb|AAP31577.1| duffy antigen/chemokine receptor [Bos indicus] Q863H8 1e-102 74% ...

  1. Korsten : tellimata tellised = Chimney : an outside job / Andres Aule

    Index Scriptorium Estoniae

    Aule, Andres

    2012-01-01

    Aap Kaur Suvi kavandatud Tallinna linnainstallatsioonide festivali "LIFT11" installatsioonist "Korsten", mis pidi seisnema Tauno Kangro skulptuuri "Lõbus korstnapühkija" ümber ajutise telliskorstna ehitamises. Lift11 jättis selle installatsiooni ära, kuid ootamatult sai "Korsten" kodanikualgatusena 8. IX 2011 teoks

  2. NCBI nr-aa BLAST: CBRC-LAFR-01-0231 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0231 ref|NP_852970.1| hypothetical protein MGA_0954 [Mycoplasma galliseptic...um R] gb|AAP56538.1| conserved hypothetical protein [Mycoplasma gallisepticum R] NP_852970.1 0.033 23% ...

  3. NCBI nr-aa BLAST: CBRC-DDIS-02-0111 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DDIS-02-0111 ref|NP_853044.1| hypothetical protein MGA_1103 [Mycoplasma galliseptic...um R] gb|AAP56612.1| conserved hypothetical protein [Mycoplasma gallisepticum R] NP_853044.1 0.003 24% ...

  4. NCBI nr-aa BLAST: CBRC-DNOV-01-0511 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-0511 ref|NP_852884.1| hypothetical protein MGA_0805 [Mycoplasma galliseptic...um R] gb|AAP56452.1| conserved hypothetical protein [Mycoplasma gallisepticum R] NP_852884.1 0.73 23% ...

  5. NCBI nr-aa BLAST: CBRC-DDIS-02-0086 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DDIS-02-0086 ref|NP_853044.1| hypothetical protein MGA_1103 [Mycoplasma galliseptic...um R] gb|AAP56612.1| conserved hypothetical protein [Mycoplasma gallisepticum R] NP_853044.1 0.003 24% ...

  6. NCBI nr-aa BLAST: CBRC-ATHA-05-0017 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ATHA-05-0017 ref|NP_852878.1| hypothetical protein MGA_0797 [Mycoplasma galliseptic...um R] gb|AAP56446.1| unique hypothetical protein [Mycoplasma gallisepticum R] NP_852878.1 0.43 26% ...

  7. NCBI nr-aa BLAST: CBRC-BTAU-01-1813 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-1813 ref|NP_852880.1| hypothetical protein MGA_0800 [Mycoplasma galliseptic...um R] gb|AAP56448.1| unique hypothetical protein [Mycoplasma gallisepticum R] NP_852880.1 0.39 21% ...

  8. NCBI nr-aa BLAST: CBRC-DNOV-01-0787 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-0787 ref|NP_853432.1| hypothetical protein MGA_0477 [Mycoplasma galliseptic...um R] gb|AAP57000.1| unique hypothetical protein [Mycoplasma gallisepticum R] NP_853432.1 0.047 27% ...

  9. Gay and Lesbian Parents

    Science.gov (United States)

    ... may benefit from meeting other children who have gay or lesbian parents. You might find a local group of families, or your children might be interested in joining an e-mail list or finding a pen pal. Civil marriage. The AAP supports civil marriage for all parents. ...

  10. Zirconyl acetaminophen phosphate: A nanoscaled analgetic with very high drug load.

    Science.gov (United States)

    Heck, Joachim G; Feldmann, Claus

    2016-11-01

    Drug release belongs to the most challenging aspects of nanoparticles addressing molecular biology and medicine. Besides targeted delivery, obvious challenges are related to high drug load and continuous slow drug release. Based on our recently developed concept of inorganic-organic hybrid nanoparticles (IOH-NP), we here present [ZrO](2+)[AAP](2-) IOH-NPs containing the analgetic phosphate prodrug acetaminophen phosphate for drug release. [ZrO](2+)[AAP](2-) combines an uncomplex synthesis in water with a high prodrug load of 68wt.%. [ZrO](2+)[AAP](2-) nanoparticles exhibit a diameter of 37(11)nm and can be readily obtained as colloidally highly stable suspension in water. The chemical composition is studied in detail based on infrared spectroscopy, energy-dispersive X-ray analysis, thermogravimetry and elemental analysis. Moreover, the release of acetaminophen from [ZrO](2+)[AAP](2-) is studied by means of model experiments indicating the carbon content of the nanoparticles and, in alternative, the fluorescence of labeled nanoparticles. Both data show a continuous release of 80wt.% of the analgetic acetaminophen on a time scale up to 48h. PMID:27451036

  11. NCBI nr-aa BLAST: CBRC-PMAR-01-0463 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PMAR-01-0463 ref|NP_833085.1| Collagen-like triple helix repeat protein [Bacil...lus cereus ATCC 14579] gb|AAP10286.1| Collagen-like triple helix repeat protein [Bacillus cereus ATCC 14579] NP_833085.1 5e-32 37% ...

  12. NCBI nr-aa BLAST: CBRC-DNOV-01-2484 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-2484 ref|YP_006355.1| ATP synthase F0 subunit 6 [Siphonodentalium loba...tum] gb|AAP91676.1| ATP synthase F0 subunit 6 [Siphonodentalium lobatum] YP_006355.1 5e-04 29% ...

  13. NCBI nr-aa BLAST: CBRC-TSYR-01-1170 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TSYR-01-1170 ref|NP_898745.1| putative cadmium resistance protein (CadA) [Rhod...ococcus erythropolis] gb|AAP74015.1| putative cadmium resistance protein (CadA) [Rhodococcus erythropolis] NP_898745.1 0.14 29% ...

  14. Using Acetaminophen's Toxicity Mechanism to Enhance Cisplatin Efficacy in Hepatocarcinoma and Hepatoblastoma Cell Lines

    Directory of Open Access Journals (Sweden)

    Alexander J. Neuwelt

    2009-10-01

    Conclusions: Our results suggest that a chemotherapeutic regimen containing both AAP and CDDP with delayed NAC rescue has the potential to enhance chemotherapeutic efficacy while decreasing adverse effects. This would be a promising approach particularly for hepatoblastomas regardless of cellular CYP2E1 protein level but could also be beneficial in other malignancies.

  15. 扑热息痛肝损伤机制研究进展%Advances on mechanisms of acetaminophen-induced hepatic injury

    Institute of Scientific and Technical Information of China (English)

    顾兴丽; 孙继红; 季晖

    2009-01-01

    Acetaminophen(AAP) -induced hepatic injury is one of the common causes of drug-induced hepatic injury. Up to date, the mechanisms of AAP-induced hepatic injury are still incompletely understood. Recent advances suggest that reactive metabolite formation, glutathione depletion, alkylation of proteins, especially mitochondrial proteins and peroxynitrite formation are critical initiating events for the toxicity. This review will focus on more recent advances in mitochon- drial dysfunction after AAP overdose. Additional, oxi-dative stress and inflammatory mediators are also important for the overall outcome.%扑热息痛(AAP)肝损伤是药物性肝损伤的常见原因之一.但迄今为止,其肝损伤机制仍不完全清楚.最新研究进展指出活性代谢产物的形成、谷胱甘肽的耗竭、线粒体蛋白的烷化和过氧化亚硝酸盐的形成是主要原因.本文主要描述了AAP过量所致的线粒体功能异常的研究进展,另外也综述了氧化应激和炎症介质在扑热息痛肝损伤机制中的作用.

  16. NCBI nr-aa BLAST: CBRC-MDOM-04-0142 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MDOM-04-0142 ref|YP_073290.1| NADH dehydrogenase subunit 5 [Pachypsylla venust...a] gb|AAP14655.1| NADH dehydrogenase subunit 5 [Pachypsylla venusta] YP_073290.1 0.039 25% ...

  17. Well-Child-Care - A Check-Up for Success

    Science.gov (United States)

    ... a Pediatrician Family Life Medical Home Health Insurance Pediatric Specialists Family Dynamics Media Work & Play Getting Involved in Your Community Healthy Children > Family Life > Medical Home > AAP Schedule of Well-Child Care Visits Family Life Listen Español Text Size Email ...

  18. NCBI nr-aa BLAST: CBRC-TNIG-09-0017 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TNIG-09-0017 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 83% ...

  19. NCBI nr-aa BLAST: CBRC-OLAT-07-0020 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OLAT-07-0020 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 76% ...

  20. NCBI nr-aa BLAST: CBRC-GACU-17-0011 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GACU-17-0011 ref|NP_989793.1| potassium voltage-gated channel, shaker-related ...subfamily, member 10 [Gallus gallus] gb|AAP94024.1| shaker subfamily potassium channel KCNA10 [Gallus gallus] NP_989793.1 0.0 68% ...

  1. NCBI nr-aa BLAST: CBRC-OLAT-07-0019 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OLAT-07-0019 ref|NP_989793.1| potassium voltage-gated channel, shaker-related ...subfamily, member 10 [Gallus gallus] gb|AAP94024.1| shaker subfamily potassium channel KCNA10 [Gallus gallus] NP_989793.1 0.0 72% ...

  2. NCBI nr-aa BLAST: CBRC-XTRO-01-2371 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-2371 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 78% ...

  3. NCBI nr-aa BLAST: CBRC-CPOR-01-0502 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CPOR-01-0502 ref|NP_989793.1| potassium voltage-gated channel, shaker-related ...subfamily, member 10 [Gallus gallus] gb|AAP94024.1| shaker subfamily potassium channel KCNA10 [Gallus gallus] NP_989793.1 0.0 78% ...

  4. NCBI nr-aa BLAST: CBRC-ACAR-01-1044 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ACAR-01-1044 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 90% ...

  5. NCBI nr-aa BLAST: CBRC-DRER-06-0073 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DRER-06-0073 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 74% ...

  6. NCBI nr-aa BLAST: CBRC-DRER-26-0215 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DRER-26-0215 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 74% ...

  7. NCBI nr-aa BLAST: CBRC-TGUT-29-0000 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TGUT-29-0000 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 98% ...

  8. NCBI nr-aa BLAST: CBRC-FRUB-02-0329 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FRUB-02-0329 ref|NP_989793.1| potassium voltage-gated channel, shaker-related ...subfamily, member 10 [Gallus gallus] gb|AAP94024.1| shaker subfamily potassium channel KCNA10 [Gallus gallus] NP_989793.1 0.0 71% ...

  9. NCBI nr-aa BLAST: CBRC-FRUB-02-0328 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FRUB-02-0328 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 84% ...

  10. NCBI nr-aa BLAST: CBRC-GACU-17-0012 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GACU-17-0012 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 74% ...

  11. NCBI nr-aa BLAST: CBRC-OLAT-26-0139 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OLAT-26-0139 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 81% ...

  12. Enhancing School Asthma Action Plans: Qualitative Results from Southeast Minnesota Beacon Stakeholder Groups

    Science.gov (United States)

    Egginton, Jason S.; Textor, Lauren; Knoebel, Erin; McWilliams, Deborah; Aleman, Marty; Yawn, Barbara

    2013-01-01

    Background: This study explores ways southeast Minnesota schools currently address asthma problems, identifies areas for improvement, and assesses the potential value of asthma action plans (AAPs) in schools. Methods: Focus groups were used to query stakeholder groups on asthma care in schools. Groups were held separately for elementary school…

  13. TEMPLATE POLYMERIZATION OF N-VINYLIMIDAZOLE ALONG POLY(METHACRYLIC ACID) IN WATER .2. KINETICS OF THE TEMPLATE POLYMERIZATION

    NARCIS (Netherlands)

    VANDEGRAMPEL, HT; TAN, YY; CHALLA, G

    1991-01-01

    The template polymerization of N-vinylimidazole (VIm) along poly(methacrylic acid) (PMAA) in water at 50-degrees-C with 2,2'-azobis(2-amidinopropane).2HCl (AAP) as initiator was studied by using variable initiator and monomer concentrations at constant [PMAA]/[VIm]0. From the order in [VIm] it was c

  14. Membrane-bound proteases of the gerbil subfornical organ and choroid plexus: an enzyme histochemical study.

    Science.gov (United States)

    Mitro, A; De Bault, L E

    1994-03-01

    Using enzyme-histochemical methods, the membrane-bound peptidases, gamma-glutamyl transpeptidase (gamma-GTP), microsomal alanyl aminopeptidase (mAAP), glutamyl aminopeptidase (EAP), and dipeptidyl peptidase IV (DPP IV), were studied in microvessels of the gerbil subfornical organ (SFO), choroid plexus adjacent to the SFO, and the ependyma of brain ventricle walls in the vicinity of the SFO. Vessels and microvessels of gerbil SFO and choroid plexus were positive for gamma-GTP, mAAP, and EAP, but negative for DPP IV. Blood-brain barrier (BBB) microvessels in the surrounding brain tissue also showed positive reactions for gamma-GTP, mAAP, and EAP but a negative reaction for DPP IV. Both epithelial cells of the choroid plexus and ependymal cells of the ventricle walls were negative for all four studied enzymes. It is suggested that blood-borne peptide hormones which can be substrates for these membrane-bound proteases can be modulated by gamma-GTP, mAAP, and EAP, but not by DPP IV, when they come in contact with the plasma membrane of the endothelial cells of the vessels in gerbil SFO, choroid plexus, and surrounding brain tissue.

  15. NCBI nr-aa BLAST: CBRC-XTRO-01-2525 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-2525 ref|NP_873727.1| rod shape-determining protein MreD [Haemophilus ...ducreyi 35000HP] gb|AAP96116.1| rod shape-determining protein MreD [Haemophilus ducreyi 35000HP] NP_873727.1 0.35 24% ...

  16. NCBI nr-aa BLAST: CBRC-LAFR-01-1699 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-1699 ref|NP_874008.1| putative sodium/alanine symporter [Haemophilus d...ucreyi 35000HP] gb|AAP96397.1| putative sodium/alanine symporter [Haemophilus ducreyi 35000HP] NP_874008.1 2.0 23% ...

  17. NCBI nr-aa BLAST: CBRC-ACAR-01-0210 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ACAR-01-0210 ref|NP_873236.1| branched-chain amino acid carrier protein [Haemophilus... ducreyi 35000HP] gb|AAP95625.1| branched-chain amino acid carrier protein [Haemophilus ducreyi 35000HP] NP_873236.1 1.2 22% ...

  18. NCBI nr-aa BLAST: CBRC-ETEL-01-0133 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0133 ref|NP_874194.1| putative enterobacterial common antigen polymerase [Haemophilus... ducreyi 35000HP] gb|AAP96583.1| putative polysaccharide biosynthesis protein [Haemophilus ducreyi 35000HP] NP_874194.1 1.9 29% ...

  19. ADHD Diagnosis and Management: A Practical Guide for the Clinic and the Classroom

    Science.gov (United States)

    Wolraich, Mark L.; DuPaul, George J.

    2010-01-01

    Effective, "integrated" care across clinical, classroom, and home settings: that's what every student with ADHD needs to achieve academic and social success. Now professionals have one complete, highly accessible guide to delivering this kind of coordinated treatment for children in Grades 1-8. Aligned with the AAP's new guidelines for ADHD…

  20. NCBI nr-aa BLAST: CBRC-DYAK-04-0025 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DYAK-04-0025 ref|NP_834435.1| Spore germination protein IA [Bacillus cereus AT...CC 14579] gb|AAP11636.1| Spore germination protein IA [Bacillus cereus ATCC 14579] NP_834435.1 0.044 23% ...

  1. Using Digital Materials in Online Courses: A Cautionary Tale of Georgia State University

    Science.gov (United States)

    Talab, Rosemary

    2008-01-01

    On April 15, 2008, a lawsuit was filed against Georgia State University by Cambridge University Press, Oxford University Press, and Sage, supported by the American University Presses (AAP). The complaint asserted ""pervasive, flagrant, and ongoing" unauthorized distribution of copyrighted materials...through its electronic course reserves service,…

  2. NCBI nr-aa BLAST: CBRC-DNOV-01-1344 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-1344 ref|YP_223898.1| putative tape measure protein [Lactobacillus pha...ge phiJL-1] gb|AAP74525.1| putative tape measure protein [Lactobacillus plantarum bacteriophage phiJL-1] YP_223898.1 0.015 22% ...

  3. Diversity of cultivated and metabolically active aerobic anoxygenic phototrophic bacteria along an oligotrophic gradient in the Mediterranean Sea

    Directory of Open Access Journals (Sweden)

    C. Jeanthon

    2011-05-01

    Full Text Available Aerobic anoxygenic phototrophic (AAP bacteria play significant roles in the bacterioplankton productivity and biogeochemical cycles of the surface ocean. In this study, we applied both cultivation and mRNA-based molecular methods to explore the diversity of AAP bacteria along an oligotrophic gradient in the Mediterranean Sea in early summer 2008. Colony-forming units obtained on three different agar media were screened for the production of bacteriochlorophyll-a (BChl-a, the light-harvesting pigment of AAP bacteria. BChl-a-containing colonies represented a low part of the cultivable fraction. In total, 52 AAP strains were isolated and the phylogenetic analyses based on their 16S rRNA and pufM genes showed that they were all affiliated to the Alphaproteobacteria. The most frequently isolated strains belonged to Citromicrobium bathyomarinum, and Erythrobacter and Roseovarius species. Most other isolates were related to species not reported to produce BChl-a and/or may represent novel taxa. Direct extraction of RNA from seawater samples enabled the analysis of the expression of pufM, the gene coding for the M subunit of the reaction centre complex of aerobic anoxygenic photosynthesis. Clone libraries of pufM gene transcripts revealed that most phylotypes were highly similar to sequences previously recovered from the Mediterranean Sea and a large majority (~94% was affiliated with the Gammaproteobacteria. The most abundantly detected phylotypes occurred in the western and eastern Mediterranean basins. However, some were exclusively detected in the eastern basin, reflecting the highest diversity of pufM transcripts observed in this ultra-oligotrophic region. To our knowledge, this is the first study to document extensively the diversity of AAP isolates and to unveil the active AAP community in an oligotrophic marine environment. By pointing out the

  4. Diversity of cultivated and metabolically active aerobic anoxygenic phototrophic bacteria along an oligotrophic gradient in the Mediterranean Sea

    Directory of Open Access Journals (Sweden)

    C. Jeanthon

    2011-07-01

    Full Text Available Aerobic anoxygenic phototrophic (AAP bacteria play significant roles in the bacterioplankton productivity and biogeochemical cycles of the surface ocean. In this study, we applied both cultivation and mRNA-based molecular methods to explore the diversity of AAP bacteria along an oligotrophic gradient in the Mediterranean Sea in early summer 2008. Colony-forming units obtained on three different agar media were screened for the production of bacteriochlorophyll-a (BChl-a, the light-harvesting pigment of AAP bacteria. BChl-a-containing colonies represented a low part of the cultivable fraction. In total, 54 AAP strains were isolated and the phylogenetic analyses based on their 16S rRNA and pufM genes showed that they were all affiliated to the Alphaproteobacteria. The most frequently isolated strains belonged to Citromicrobium bathyomarinum, and Erythrobacter and Roseovarius species. Most other isolates were related to species not reported to produce BChl-a and/or may represent novel taxa. Direct extraction of RNA from seawater samples enabled the analysis of the expression of pufM, the gene coding for the M subunit of the reaction centre complex of aerobic anoxygenic photosynthesis. Clone libraries of pufM gene transcripts revealed that most phylotypes were highly similar to sequences previously recovered from the Mediterranean Sea and a large majority (~94 % was affiliated to the Gammaproteobacteria. The most abundantly detected phylotypes occurred in the western and eastern Mediterranean basins. However, some were exclusively detected in the eastern basin, reflecting the highest diversity of pufM transcripts observed in this ultra-oligotrophic region. To our knowledge, this is the first study to document extensively the diversity of AAP isolates and to unveil the active AAP community in an oligotrophic marine environment. By pointing out the discrepancies

  5. [Activity of alanine aminopeptidase in blood and in urine of smoking and non-smoking smelters].

    Science.gov (United States)

    Bizoń, Anna; Stasiak, Karolina; Milnerowicz, Halina

    2010-01-01

    The human body is constantly exposed to xenobiotics. This will include exogenous substances from environmental pollution such as heavy metals and lifestyle such as smoking, which may lead to impaired functioning of many organs. The liver and kidney are the critical organs in the case of a long-term occupational or environmental exposure to heavy metals and tobacco smoke. In diagnostics of liver and kidney damage useful are the methods which determine the activity of enzymes such as alanine aminopeptidase (AAP). AAP is a marker for early detection of acute kidney damage, and presence of AAP derive mainly from proximal tubular brush-border. Activity of AAP in urine allows to assess the damage resulting from the nephrotoxic exposure to heavy metals. In the serum AAP is mainly from hepatic. Activity of AAP may be useful to identify liver cancer. The investigation was shown, that AAP activity in the blood is used to detect hepatic cholestasis and congestive jaundice. The aim of present study was to assess the influence of occupational exposure of copper-foundry workers to heavy metals (arsenic, cadmium, lead) on activity of alanine aminopeptidase in blood and urine. The investigations were performed in blood and urine of 166 subjects: 101 male copper smelters and 65 non-exposed male subjects. The study protocol was approved by Local Bioethics Committee of Wroclaw Medical University (KB No: 469/2008). The data on smoking which had been obtained from a direct personal interview were verified by determination of serum cotinine concentrations. Biological material collected from the control group and smelters was divided into subgroups of nonsmokers and smokers. The concentrations of lead and cadmium were determined in whole blood, whilst the level of arsenic and cadmium were determined in urine using FAAS method (Flame Atomic Absorption Spectrometry) in the acetylate flame on the SOLAAR M6. The activity of AA was determined in blood and in urine. The results showed a 9-fold

  6. Common Genetic Variation in CYP17A1 and Response to Abiraterone Acetate in Patients with Metastatic Castration-Resistant Prostate Cancer.

    Science.gov (United States)

    Binder, Moritz; Zhang, Ben Y; Hillman, David W; Kohli, Rhea; Kohli, Tanvi; Lee, Adam; Kohli, Manish

    2016-01-01

    Treatment with abiraterone acetate and prednisone (AA/P) prolongs survival in metastatic castration-resistant prostate cancer (mCRPC) patients. We evaluated the genetic variation in CYP17A1 as predictive of response to AA/P. A prospective collection of germline DNA prior to AA/P initiation and follow-up of a mCRPC cohort was performed. Five common single-nucleotide polymorphisms (SNPs) in CYP17A1 identified using a haplotype-based tagging algorithm were genotyped. Clinical outcomes included biochemical response and time to biochemical progression on AA/P. Logistic regression was used to assess the association between tag SNPs and biochemical response. Proportional hazards regression was used to assess the association between tag SNPs and time to biochemical progression. Odds or hazard ratio per minor allele were estimated and p-values below 0.05 were considered statistically significant. Germline DNA was successfully genotyped for four tag SNPs in 87 patients. The median age was 73 years (54-90); the median prostate-specific antigen was 66 ng/dL (0.1-99.9). A single SNP, rs2486758, was associated with lower odds of experiencing a biochemical response (Odds ratio 0.22, 95% confidence interval 0.07-0.63, p = 0.005) and a shorter time to biochemical progression (Hazard ratio 2.23, 95% confidence interval 1.39-3.56, p < 0.001). This tag SNP located in the promoter region of CYP17A1 will need further validation as a predictive biomarker for AA/P therapy. PMID:27409606

  7. Premature adrenarche: etiology, clinical findings, and consequences.

    Science.gov (United States)

    Voutilainen, Raimo; Jääskeläinen, Jarmo

    2015-01-01

    Adrenarche means the morphological and functional change of the adrenal cortex leading to increasing production of adrenal androgen precursors (AAPs) in mid childhood, typically at around 5-8 years of age in humans. The AAPs dehydroepiandrosterone (DHEA) and its sulfate conjugate (DHEAS) are the best serum markers of adrenal androgen (AA) secretion and adrenarche. Normal ACTH secretion and action are needed for adrenarche, but additional inherent and exogenous factors regulate AA secretion. Inter-individual variation in the timing of adrenarche and serum concentrations of DHEA(S) in adolescence and adulthood are remarkable. Premature adrenarche (PA) is defined as the appearance of clinical signs of androgen action (pubic/axillary hair, adult type body odor, oily skin or hair, comedones, acne, accelerated statural growth) before the age of 8 years in girls or 9 years in boys associated with AAP concentrations high for the prepubertal chronological age. To accept the diagnosis of PA, central puberty, adrenocortical and gonadal sex hormone secreting tumors, congenital adrenal hyperplasia, and exogenous source of androgens need to be excluded. The individually variable peripheral conversion of circulating AAPs to biologically more active androgens (testosterone, dihydrotestosterone) and the androgen receptor activity in the target tissues are as important as the circulating AAP concentrations as determinants of androgen action. PA has gained much attention during the last decades, as it has been associated with small birth size, the metabolic and polycystic ovarian syndrome (PCOS), and thus with an increased risk for type 2 diabetes and cardiovascular diseases in later life. The aim of this review is to describe the known hormonal changes and their possible regulators in on-time and premature adrenarche, and the clinical features and possible later health problems associating with PA. PMID:24923732

  8. Diverse arrangement of photosynthetic gene clusters in aerobic anoxygenic phototrophic bacteria.

    Directory of Open Access Journals (Sweden)

    Qiang Zheng

    Full Text Available BACKGROUND: Aerobic anoxygenic photototrophic (AAP bacteria represent an important group of marine microorganisms inhabiting the euphotic zone of the ocean. They harvest light using bacteriochlorophyll (BChl a and are thought to be important players in carbon cycling in the ocean. METHODOLOGY/PRINCIPAL FINDINGS: Aerobic anoxygenic phototrophic (AAP bacteria represent an important part of marine microbial communities. Their photosynthetic apparatus is encoded by a number of genes organized in a so-called photosynthetic gene cluster (PGC. In this study, the organization of PGCs was analyzed in ten AAP species belonging to the orders Rhodobacterales, Sphingomonadales and the NOR5/OM60 clade. Sphingomonadales contained comparatively smaller PGCs with an approximately size of 39 kb whereas the average size of PGCs in Rhodobacterales and NOR5/OM60 clade was about 45 kb. The distribution of four arrangements, based on the permutation and combination of the two conserved regions bchFNBHLM-LhaA-puhABC and crtF-bchCXYZ, does not correspond to the phylogenetic affiliation of individual AAP bacterial species. While PGCs of all analyzed species contained the same set of genes for bacteriochlorophyll synthesis and assembly of photosynthetic centers, they differed largely in the carotenoid biosynthetic genes. Spheroidenone, spirilloxanthin, and zeaxanthin biosynthetic pathways were found in each clade respectively. All of the carotenoid biosynthetic genes were found in the PGCs of Rhodobacterales, however Sphingomonadales and NOR5/OM60 strains contained some of the carotenoid biosynthetic pathway genes outside of the PGC. CONCLUSIONS/SIGNIFICANCE: Our investigations shed light on the evolution and functional implications in PGCs of marine aerobic anoxygenic phototrophs, and support the notion that AAP are a heterogenous physiological group phylogenetically scattered among Proteobacteria.

  9. Metabolic Disturbances Independent of Body Mass in Patients with Schizophrenia Taking Atypical Antipsychotics

    Science.gov (United States)

    Lee, Jong Il

    2015-01-01

    Objective Atypical antipsychotic (AAP) treatment is associated with weight gain and metabolic disturbances such as dyslipidemia and dysglycemia. The metabolic disturbances are usually considered to develop secondary to weight gain. We performed the comparison of metabolic disturbances of three AAP group with different risk of metabolic side effect after adjusting for body mass to investigate whether any metabolic disturbances develop independently from body mass index (BMI). Methods This cross-sectional study included 174 subjects with schizophrenia who were on 1) monotherapy with clozapine (CL), olanzapine (OL), or quetiapine (QT) (n=61), 2) monotherapy with risperidone (RSP) (n=89), or 3) monotherapy with aripiprizole (ARP), or ziprasidone (ZPS) (n=24) more than 1 year. Association between the prevalence of metabolic disturbances and groups were analysed using logistic regression after adjusting confounding variables including BMI. Analysese of covariance were used to compare the AAP groups in terms of the levels of metabolic parameters. Results There were significant differences among groups in terms of the prevalence of hypertriglyceridemia (p=0.015), low HDL-cholesterol (p=0.017), and hyperglycemia (p=0.022) after adjusting for BMI. Triglyceride level (p=0.014) and the ratio of triglyceride to HDL-cholesterol (p=0.004) were significantly different among groups after adjusting for BMI. Conclusion In conclusion, metabolic disturbances are significantly different in AAP groups even after adjusting BMI. AAPs may have direct effect on metabolic parameters. Blood lipid and glucose levels should be monitored regularly regardless of whether patients tend to gain weight. PMID:25866526

  10. Clinical diagnosis and treatment of asparaginase associated pancreatitis in adults%成人门冬酶相关胰腺炎的临床诊治

    Institute of Scientific and Technical Information of China (English)

    李梦洁; 何牧卿; 沈益民

    2015-01-01

    目的 探讨成人门冬酶相关胰腺炎(AAP)的临床特点及诊治过程,旨在提高AAP诊治水平.方法 回顾性分析2009年1月至2015年6月间浙江医院血液内科及温州医科大学附属第二医院血液科收治的384例急性淋巴细胞白血病(ALL)患者的临床资料,所有患者均给予含培门冬酶或左旋门冬酰胺酶(L-asp)的多药联合化疗,分析AAP的发生情况、临床表现、诊断、治疗及转归.结果 384例ALL患者中18例发生AAP,发生率为4.7%,其中轻症AAP (MAAP) 13例,重症AAP(SAAP)5例.16例AAP发生在诱导化疗期,2例发生在维持强化期.腹痛为主要临床表现,血淀粉酶及脂肪酶活性均升高.治疗后,MAAP患者的腹痛症状缓解,血淀粉酶及脂肪酶活性明显下降,继续使用培门冬酶或L-asp化疗,未见胰腺炎复发.5例SAAP患者血淀粉酶及脂肪酶反复升高,其中1例因合并重症感染及囊肿破裂出血而病死.结论 成人ALL患者在门冬酶化疗期间出现腹痛症状应考虑AAP可能,加强血淀粉酶及脂肪酶检测,辅以B超和CT检查有助于早期诊治AAP,并改善患者预后.%Objective To investigate the clinical characteristics and the course of diagnosis and therapy of asparaginase associated pancreatitis (AAP) in adults, in order to improve the ability of diagnosis and treatment.Methods Data of 384 cases of acute lymphoblastic leukemia (ALL) who received treatment in Department of Hematology, Zhejiang Hospital, and Department of Hematology, Second Hospital Affiliated to Wenzhou Medical University from January 2009 to June 2015 was retrospectively analyzed.All patients were given multi-drug chemotherapy including PEG-asparaginase or L-asparaginase, the incidence of AAP, clinical manifestations, diagnosis, treatment and prognosis were analyzed.Results Among the 384 cases, 18 patients developed AAP, and the incidence of AAP was 4.7%, including 13 cases of mild AAP (MAAP), 5 cases of severe AAP (SAAP).Sixteen cases of

  11. 门冬酰胺酶相关儿童急性胰腺炎诊治研究进展%Progress of diagnosis and treatment of asparaginase associated pancreatitis in children

    Institute of Scientific and Technical Information of China (English)

    石苇

    2016-01-01

    门冬酰胺酶(ASP)是儿童急性淋巴细胞白血病和非霍奇金淋巴瘤联合化疗方案中的关键药物之一.ASP相关急性胰腺炎(AAP)是ASP的主要严重不良反应.现通过复习有关儿童AAP的近年国内外文献和我国《培门冬酶治疗急性淋巴细胞白血病和恶性淋巴瘤的专家共识》,以及对网络收集的历年来我国儿童AAP报道资料进行归纳与统计分析,参照国际AAP诊断标准,提出儿童AAP流行病学、临床表现、早期诊断和有效治疗要点,以及左旋门冬酰胺酶和培门冬酶的AAP临床对比.全文资料数据详尽,分析归纳依据充分,相关经验的临床可操作性强,对临床有效诊治儿童AAP具有较大的参考价值.%Asparaginase(ASP) is an important drug in the treatment of childhood acute lymphoblastic leukemia and non-Hodgkin lymphoma.Asparaginase associated pancreatitis (AAP) is the main treatment-adverse events of asparaginase.After reviewing the recent foreign literatures about AAP and the Chinese expert about polyethylene glycol conjugated asparaginase (PEG-ASP) in the treatment of acute lymphoblastic leukemia and malignant lymphoma with asparaginase,conclude and analysis the data about childhood AAP and show the epidemiology,clinical features,early diagnosis and effective treatment of children with AAP.Make clinical compare of L-asparaginase and PEG-ASP.Based on the full grasp of the relevant data,analyzing,introducing and integrating,this may be helpful to the diagnosis and treatment of childhood AAP.

  12. Au@Ag/Au nanoparticles assembled with activatable aptamer probes as smart ``nano-doctors'' for image-guided cancer thermotherapy

    Science.gov (United States)

    Shi, Hui; Ye, Xiaosheng; He, Xiaoxiao; Wang, Kemin; Cui, Wensi; He, Dinggeng; Li, Duo; Jia, Xuekun

    2014-07-01

    Although nanomaterial-based theranostics have increased positive expectations from cancer treatment, it remains challenging to develop in vivo ``nano-doctors'' that provide high-contrast image-guided site-specific therapy. Here we designed an activatable theranostic nanoprobe (ATNP) via self-assembly of activatable aptamer probes (AAPs) on Au@Ag/Au nanoparticles (NPs). As both quenchers and heaters, novel Au@Ag/Au NPs were prepared, showing excellent fluorescence quenching and more effective near-infrared photothermal therapy than Au nanorods. The AAP comprised a thiolated aptamer and a fluorophore-labeled complementary DNA; thus, the ATNP with quenched fluorescence in the free state could realize signal activation through target binding-induced conformational change of the AAP, and then achieve on-demand treatment under image-guided irradiation. By using S6 aptamer as the model, in vitro and in vivo studies of A549 lung cancer verified that the ATNP greatly improved imaging contrast and specific destruction, suggesting a robust and versatile theranostic strategy for personalized medicine in future.Although nanomaterial-based theranostics have increased positive expectations from cancer treatment, it remains challenging to develop in vivo ``nano-doctors'' that provide high-contrast image-guided site-specific therapy. Here we designed an activatable theranostic nanoprobe (ATNP) via self-assembly of activatable aptamer probes (AAPs) on Au@Ag/Au nanoparticles (NPs). As both quenchers and heaters, novel Au@Ag/Au NPs were prepared, showing excellent fluorescence quenching and more effective near-infrared photothermal therapy than Au nanorods. The AAP comprised a thiolated aptamer and a fluorophore-labeled complementary DNA; thus, the ATNP with quenched fluorescence in the free state could realize signal activation through target binding-induced conformational change of the AAP, and then achieve on-demand treatment under image-guided irradiation. By using S6 aptamer as

  13. Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children

    Directory of Open Access Journals (Sweden)

    Kohli Arunima

    2012-09-01

    Full Text Available Abstract Background Secondhand smoke (SHS and ambient air pollution (AAP exposures have been associated with increased prevalence and severity of asthma and DNA modifications of immune cells. In the current study, we examined the association between SHS and AAP with DNA methylation and expression of interferon-gamma (IFN-γ and forkhead box protein 3 (Foxp3 in T cell populations. Methods Subjects 7–18 years old were recruited from Fresno (high AAP; n = 62 and Stanford, CA (low AAP; n = 40 and divided into SHS-exposed (Fresno: n = 31, Stanford: n = 6 and non-SHS-exposed (nSHS; Fresno: n = 31, Stanford: n = 34 groups. T cells purified from peripheral blood were assessed for levels of DNA methylation and expression of IFN-γ (in effector T cells or Foxp3 (in regulatory T cells. Results Analysis showed a significant increase in mean % CpG methylation of IFN-γ and Foxp3 associated with SHS exposure (IFN-γ: FSHS 62.10%, FnSHS 41.29%, p p Foxp3: FSHS 74.60%, FnSHS 54.44%, p p IFN-γ: FSHS 0.75, FnSHS 1.52, p p Foxp3: FSHS 0.75, FnSHS 3.29, p p IFN-γ: FSHS vs. SSHS, p p Foxp3: FSHS vs. SSHS, p p IFN-γ: FSHS vs. SSHS, p p Foxp3: FSHS vs. SSHS, p p IFN-γ: p = 0.15; Foxp3: p = 0.27, nor was Foxp3 expression (p = 0.08; IFN-γ expression was significantly decreased in AAP-only subjects (p  Conclusions Exposures to SHS and AAP are associated with significant hypermethylation and decreased expression of IFN-γ in Teffs and Foxp3 in Tregs. Relative contributions of each exposure to DNA modification and asthma pathogenesis warrant further investigation.

  14. Asymmetric dimethylarginine in somatically healthy schizophrenia patients treated with atypical antipsychotics

    DEFF Research Database (Denmark)

    Jørgensen, Anders; Knorr, Ulla Benedichte Søsted; Soendergaard, Mia Greisen;

    2015-01-01

    and the L-arginine:ADMA ratio showed no correlations with oxidative stress markers, medication load, or Positive and Negative Syndrome Scale scores. CONCLUSIONS: Schizophrenia and treatment with AAP was not associated with increased levels of plasma ADMA or the L-arginine:ADMA ratio. Furthermore, plasma......BACKGROUND: Schizophrenia is associated with increased cardiovascular morbidity and mortality. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of the nitric oxide synthase, and the L-arginine:ADMA ratio are markers of endothelial dysfunction that predict mortality and adverse outcome...... in a range of cardiovascular disorders. Increased ADMA levels may also lead to increased oxidative stress. We hypothesized that ADMA and the L-arginine:ADMA ratio are increased in somatically healthy schizophrenia patients treated with atypical antipsychotics (AAP), and that the ADMA and the L-arginine: ADMA...

  15. Life without TV? cultivation theory and psychosocial health characteristics of television-free individuals and their television-viewing counterparts.

    Science.gov (United States)

    Hammermeister, Jon; Brock, Barbara; Winterstein, David; Page, Randy

    2005-01-01

    Much attention has been paid to the amount of time Americans spend watching television. Cultivation theory has been important in exploring behavioral effects of television viewing for many years. However, psychosocial health has received much less scrutiny in relation to television viewing time. This investigation examined the hypotheses that television-free individuals and viewers adhering to the American Academy of Pediatrics (AAP) recommendations (up to 2 hr of viewing per day) would display a more positive psychosocial health profile when compared with more frequent television viewers. Results confirmed the hypothesis for women, but not for men. Our analysis showed that moderate television viewing, as defined by the AAP, provides a similar relation with psychosocial health as being television-free. Results are discussed in a cultivation theory framework. PMID:15855072

  16. From porous gold nanocups to porous nanospheres and solid particles - A new synthetic approach

    KAUST Repository

    Ihsan, Ayesha

    2015-05-01

    We report a versatile approach for the synthesis of porous gold nanocups, porous gold nanospheres and solid gold nanoparticles. Gold nanocups are formed by the slow reduction of gold salt (HAuCl4{dot operator}3H2O) using aminoantipyrene (AAP) as a reducing agent. Adding polyvinylpyrrolidone (PVP) to the gold salt followed by reduction with AAP resulted in the formation of porous gold nanospheres. Microwave irradiation of both of these porous gold particles resulted in the formation of slightly smaller but solid gold particles. All these nanoparticles are thoroughly characterized by UV-visible spectroscopy, scanning electron microscopy (SEM), high resolution transmission electron microscopy (HR-TEM) and bright-field tomography. Due to the larger size, porous nature, low density and higher surface area, these nanomaterials may have interesting applications in catalysis, drug delivery, phototherapy and sensing.

  17. Vibrational spectroscopic studies and DFT calculations of 4-aminoantipyrine

    Science.gov (United States)

    Swaminathan, J.; Ramalingam, M.; Sethuraman, V.; Sundaraganesan, N.; Sebastian, S.

    2009-08-01

    The pyrazole derivative, 4-aminoantipyrine (4AAP), used as an intermediate for the synthesis of pharmaceuticals especially antipyretic and analgesic drugs has been analyzed experimentally and theoretically for its vibrational frequencies. The FTIR and FT Raman spectra of the title compound have been compared with the theoretically computed frequencies invoking the standard 6-311g(d,p) and cc-pVDZ basis sets at DFT level of theory (B3LYP). The harmonic vibrational frequencies at B3LYP/cc-pVDZ after appropriate scaling method seem to coincide satisfactorily with the experimental observations rather than B3LYP/6-311g(d,p) results. The theoretical spectrograms for FT-IR and FT-Raman spectra of 4AAP have been also constructed and compared with the experimental spectra. Additionally, thermodynamic data have also been calculated and discussed.

  18. Cadmium-induced oxidative stress in potato tuber

    Directory of Open Access Journals (Sweden)

    Andrzej Stroiński

    2014-02-01

    Full Text Available Short-term treatment of tuber discs of potato (Solanum tuberosum L. with cadmium chloride elevated the concentration of active oxygen species (.O-2, H202 and activated the antioxidative system. Two cultivars, Bintje and Bzura, susceptible and tolerant, respectively, to cadmium were examined. In more tolerant, control tissues the activity of ascorbic acid peroxidase (AAP and catalase (CAT was higher than in the sensitive ones. During first hours of stress, the inhibition of superoxide dismutase (SOD, CAT and AAP was observed and it comes from inactivation of enzymes by cadmium ions. A subsequent activity increase of the enzymes aroused earlier in tolerant tissues. It seems therefore, that tolerant tissues possess a more efficient antioxidative system.

  19. Anorexia and Attachment: Dysregulated Defense and Pathological Mourning

    Directory of Open Access Journals (Sweden)

    elisa edelvecchio

    2014-10-01

    Full Text Available The role of Defensive exclusion (Deactivation and Segregated Systems in the development of early relationships and related to subsequent manifestations of symptoms of eating disorders was assessed using the Adult Attachment Projective Picture System (AAP. Fifty-one DSM-IV diagnosed women with anorexia participated in the study. Anorexic patients were primarily classified as dismissing or unresolved. Quantitative and qualitative analyses of defensive exclusion were carried out. Results showed potential benefits of using the AAP defense exclusion coding system, in addition to the main attachment classifications, in order to better understand the developmental issues involved in anorexia. Discussion concerned the processes, such as pathological mourning, that may underlie the associations between dismissing and unresolved attachment and anorexia. Implications for developmental research and clinical nosology are discussed.

  20. Surveying college introductory physics students' attitudes and approaches to problem solving

    CERN Document Server

    Mason, Andrew

    2016-01-01

    Students' attitudes and approaches to problem solving in physics can greatly impact their actual problem solving practices and also influence their motivation to learn and ultimately the development of expertise. We developed and validated an attitudes and approaches to problem solving (AAPS) survey and administered it to students in the introductory physics courses in a typical large research university in the US. Here, we discuss the development and validation of the survey and analysis of the student responses to the survey questions in introductory physics courses. The introductory physics students' responses to the survey questions were also compared with those of physics faculty members and physics PhD students. We find that introductory students are in general less expert-like than the physics faculty members and PhD students. Moreover, on some AAPS survey questions, the responses of students and faculty have unexpected trends. Those trends were interpreted via in

  1. Surveying college introductory physics students’ attitudes and approaches to problem solving

    Science.gov (United States)

    Mason, Andrew J.; Singh, Chandralekha

    2016-09-01

    Students’ attitudes and approaches to problem solving in physics can greatly impact their actual problem solving practices and also influence their motivation to learn and ultimately the development of expertise. We developed and validated an attitudes and approaches to problem solving (AAPS) survey and administered it to students in the introductory physics courses in a typical large research university in the US. Here, we discuss the development and validation of the survey and analysis of the student responses to the survey questions in introductory physics courses. The introductory physics students’ responses to the survey questions were also compared with those of physics faculty members and physics PhD students. We find that introductory students are in general less expert-like than the physics faculty members and PhD students. Moreover, on some AAPS survey questions, the responses of students and faculty have unexpected trends. Those trends were interpreted via individual interviews, which helped clarify reasons for those survey responses.

  2. Surveying Turkish high school and university student attitudes and approaches to physics problem solving

    CERN Document Server

    Balta, Nuri; Singh, Chandralekha

    2016-01-01

    Student attitudes and approaches to problem solving can impact how well they learn physics. Prior research in the US using a validated Attitude and Approaches to Problem Solving (AAPS) survey suggests that there are major differences between students in introductory physics and astronomy courses and physics experts in terms of their attitudes and approaches to physics problem solving. Here we discuss the validation, administration and analysis of data for the Turkish version of the AAPS survey for high school and university students in Turkey. After the validation and administration of the Turkish version of the survey, the analysis of the data was conducted by grouping the data by grade level, school type, and gender. While there are no statistically significant differences between the averages of various groups on the survey, overall, the university students in Turkey were more expert-like than vocational high school students. On an item by item basis, there are statistically differences between the average...

  3. Use of cough and cold preparations during breastfeeding.

    Science.gov (United States)

    Mitchell, J L

    1999-12-01

    Adverse reactions in infants from maternal drug ingestion depend largely on the amount of milk consumed by the infant, timing of breastfeeding in relation to dosing, dose of the medication, dosing interval, and duration of therapy. When taking medications, breastfeeding mothers should be instructed to take their medication after breastfeeding, at the lowest effective dose and for the shortest duration. Overall, there are few data from human studies on the use of antihistamines, decongestants, and cough products during breastfeeding. Studies of pseudoephedrine, triprolidine, and loratadine in humans conclude that low levels of each drug would reach a breastfed infant. Since triprolidine and pseudoephedrine are also considered compatible with breastfeeding by the AAP, these 2 drugs should be the first-line choices. Codeine is considered compatible with breastfeeding by the AAP, and would be an acceptable choice for short-term use as a cough suppressant. It is important to note that many of the liquid cough and cold products contain alcohol. In addition, many of the combination products are a mixture of an antihistamine and a decongestant and may also contain aspirin, acetaminophen, ibuprofen, or caffeine. It is preferable for nursing mothers to only take medications that are necessary and to avoid such combination products. The AAP considers alcohol, acetaminophen, ibuprofen, and caffeine compatible with breastfeeding. Aspirin has been associated with significant negative effects on some nursing infants, and the AAP recommends giving aspirin to nursing mothers with caution. Mothers taking cough and cold products should watch for adverse events in their breastfed infants. Infants may experience paradoxical central nervous stimulation from antihistamines and irritability and insomnia from decongestants. PMID:10776186

  4. NCBI nr-aa BLAST: CBRC-FRUB-02-0117 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FRUB-02-0117 ref|NP_001075589.1| blood-brain barrier large neutral amino acid ...mall subunit 1 (L-type amino acid transporter 1) (4F2 light chain) (4F2 LC) (4F2LC) (LAT1 light chain) gb|AAP47189.1| blood-brain bar...rier large neutral amino acid transporter light chain [Oryctolagus cuniculus] NP_001075589.1 7e-70 61% ...

  5. Application of acid-treated yeast cell wall (AYC) as a pharmaceutical additive. II: effects of curing on the medicine release from AYC-coated tablets.

    Science.gov (United States)

    Yuasa, H; Kaneshige, J; Ozeki, T; Kasai, T; Eguchi, T; Ishiwaki, N

    2000-11-19

    Acid-treated yeast cell wall (AYC) was newly prepared by acidifying brewers' yeast cell wall. Core tablets containing 3% of acetaminophen (AAP) were coated with the AYC aqueous dispersion containing 5% (w/v) of AYC and 0.35% (w/v) of glycerol. The curing of AYC-coated tablets was performed at various curing periods of time and temperatures. The effects of curing on AAP release from AYC-coated tablets, the weight and thickness of the coated layer of AYC and the water sorption into the AYC-coated tablets were studied. The tensile strength and pore size distribution of the AYC cast film were measured. In the case of 60, 80, or 100 degrees C curing, AAP release from AYC-coated tablets showed a sigmoidal release profile with an initial lag time. The duration of the lag time increased with the increasing curing time and temperature, though the release rate after the lag time hardly changed. At 120 degrees C curing, the release rate after the lag time decreased with the increasing curing time and a sustained release was observed. The weight and thickness of the AYC-coated layer and the water sorption rate into AYC-coated tablets decreased with the increasing curing time and temperature. The tensile strength of the AYC cast film increased with increasing the curing temperature, particularly at 120 degrees C curing. It is considered that the water was evaporated from the AYC-coated layer and the adhesion force between AYC particles increased during curing, making the structure of the AYC-coated layer densely firm. The changes in the duration of lag time and the release rate may be due to changes in the structure of the AYC-coated layer caused by curing. These results show that it is feasible to control the lag time and the release rate of AAP from AYC-coated tablets by varying the curing time and temperature.

  6. One-step in situ synthesis of polyamide microcapsules with inorganic payload and their transformation into responsive thermoplastic composite materials

    OpenAIRE

    Dencheva, Nadya Vasileva; Denchev, Z.; Lanceros-Méndez, S.; Ezquerra Sanz, T.

    2016-01-01

    Well-dispersed loads of finely powdered metals, metal oxides, several carbon allotropes or nanoclays are incorporated into highly porous polyamide 6 microcapsules in controllable amounts via an original one-step in situ fabrication technique. It is based on activated anionic polymerization (AAP) of ε-caprolactam in a hydrocarbon solvent performed in the presence of the respective micro- or nanosized loads. The forming microcapsules with typical diameters of 25-50 µm entrap up ...

  7. NCBI nr-aa BLAST: CBRC-CPOR-01-1987 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available musculus] gb|AAF14225.1|AF109159_1 duffy antigen/receptor for chemokine glycoprotein [Mus musculus] gb|AAP42463.1| Duffy...CBRC-CPOR-01-1987 gb|AAF08328.1|U88431_1 Duffy-antigen receptor for chemokines [Mus... blood group antigen [Mus musculus] gb|EDL38993.1| Duffy blood group, chemokine receptor, isoform CRA_b [Mus musculus] AAF08328.1 1e-98 55% ...

  8. NCBI nr-aa BLAST: CBRC-RNOR-13-0118 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available musculus] gb|AAF14225.1|AF109159_1 duffy antigen/receptor for chemokine glycoprotein [Mus musculus] gb|AAP42463.1| Duffy...CBRC-RNOR-13-0118 gb|AAF08328.1|U88431_1 Duffy-antigen receptor for chemokines [Mus... blood group antigen [Mus musculus] gb|EDL38993.1| Duffy blood group, chemokine receptor, isoform CRA_b [Mus musculus] AAF08328.1 1e-152 79% ...

  9. NCBI nr-aa BLAST: CBRC-MMUS-01-0083 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available musculus] gb|AAF14225.1|AF109159_1 duffy antigen/receptor for chemokine glycoprotein [Mus musculus] gb|AAP42463.1| Duffy...CBRC-MMUS-01-0083 gb|AAF08328.1|U88431_1 Duffy-antigen receptor for chemokines [Mus... blood group antigen [Mus musculus] gb|EDL38993.1| Duffy blood group, chemokine receptor, isoform CRA_b [Mus musculus] AAF08328.1 0.0 97% ...

  10. Meeting Report: Metabolites in Safety Testing (MIST) Symposium—Safety Assessment of Human Metabolites: What’s REALLY Necessary to Ascertain Exposure Coverage in Safety Tests?

    OpenAIRE

    GAO Hongying; Jacobs, Abigail; White, Ronald E.; Booth, Brian P.; Obach, R Scott

    2013-01-01

    In the 2012 AAPS metabolites in safety testing (MIST) symposium held in Chicago, IL, USA, on October 15, 2012, regulatory experts and industrial scientists joined together to discuss their perspectives and strategies in addressing contemporary MIST recommendations (FDA 2008, International Conference on Harmonization (ICH) M3(R2), ICH M(R2) Q&A). Overall, these regulatory guidances indicate that metabolites identified in human plasma should circulate at similar or greater concentrations in at ...

  11. Modeling the Potential Impact of the 2014 American Academy of Pediatrics Respiratory Syncytial Virus Prophylaxis Guidance on Preterm Infant RSV Outcomes

    OpenAIRE

    McLaurin, Kimmie K.; Chatterjee, Archana; Makari, Doris

    2015-01-01

    Introduction The American Academy of Pediatrics (AAP) Committee on Infectious Diseases issued updated guidance on respiratory syncytial virus (RSV) prophylaxis in 2014. This report models the potential impact of the new guidance on RSV outcomes in preterm infants 29–34 weeks’ gestational age (wGA) without chronic lung disease in the United States. Methods The number of preterm infants was estimated using 2012 natality data. Palivizumab utilization prior to the 2014 guidance update was estimat...

  12. EST Table: CK520549 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK520549 rswea0_004258.y1 10/09/29 45 %/102 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swe ...

  13. EST Table: CK529907 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK529907 rswfa0_000778.y1 10/09/29 58 %/131 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swf ...

  14. EST Table: CK544693 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK544693 rswhb0_014928.y1 10/09/29 53 %/193 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swh ...

  15. EST Table: CK528102 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK528102 rswfa0_005915.y1 10/09/29 40 %/123 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swf ...

  16. EST Table: CN376273 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CN376273 rzhswab0_002215 10/09/28 42 %/131 aa ref|YP_145791.1| polyprotein [Varroa ...destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/09/01 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 L12 ...

  17. EST Table: CK528690 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK528690 rswfa0_007768.y1 11/12/09 10/09/29 51 %/217 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swf ...

  18. EST Table: DN237490 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available 019079(viral genome replication) 10/09/29 44 %/102 aa ref|YP_145791.1| polyprotein [Varroa destructor virus ...1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/09/03 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h DN237490 BmP ...

  19. EST Table: CK510758 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK510758 rswdd0_006586.y1 10/09/29 52 %/216 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/30 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swd ...

  20. EST Table: DN237513 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available DN237513 EST00639 10/09/29 45 %/111 aa ref|YP_145791.1| polyprotein [Varroa destruc...tor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/09/03 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h DN237490 BmP ...

  1. EST Table: CK489452 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK489452 rswab0_007236.y1 10/09/29 42 %/134 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/30 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swa ...

  2. EST Table: CK541979 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK541979 rswhb0_006233.y1 10/09/29 48 %/164 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swh ...

  3. EST Table: CK523603 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK523603 rswea0_009713.y1 10/09/29 47 %/185 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h DN237490 swe ...

  4. EST Table: CK518734 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK518734 rswea0_001019.y1 10/09/29 39 %/171 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h DN237490 swe ...

  5. EST Table: CK501708 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK501708 rswcc0_001346.y1 10/09/29 45 %/174 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/30 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h DN237490 swc ...

  6. Chapter Oral Health Advocates: A Nationwide Model for Pediatrician Peer Education and Advocacy about Oral Health

    OpenAIRE

    Lewis, Charlotte W.; Lauren Barone; Rocio B. Quinonez; Suzanne Boulter; Mouradian, Wendy E.

    2013-01-01

    Objective. (1) To describe an innovative program training US pediatricians to be Chapter Oral Health Advocates (COHAs). (2) To provide insight into COHAs’ experiences disseminating oral health knowledge to fellow pediatricians. Patients and Methods. Interviews with 40 COHAs who responded to an email request, from a total of 64 (62% response). Transcripts were analyzed for common themes about COHA activities, facilitators, and barriers. Results. COHAs reported positive experiences at the AAP ...

  7. NCBI nr-aa BLAST: CBRC-LAFR-01-2611 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-2611 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-140 77% ...

  8. NCBI nr-aa BLAST: CBRC-LAFR-01-0121 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0121 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-111 81% ...

  9. NCBI nr-aa BLAST: CBRC-LAFR-01-0651 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0651 ref|NP_666854.1| olfactory receptor 1155 [Mus musculus] gb|AAL61117.1| olfactory... receptor MOR174-10 [Mus musculus] gb|AAP71568.1| olfactory receptor Olfr1155 [Mus musculus] emb|CAM18637.1| olfactory... receptor 1155 [Mus musculus] gb|EDL27414.1| olfactory receptor 1155 [Mus musculus] NP_666854.1 1e-123 72% ...

  10. NCBI nr-aa BLAST: CBRC-EEUR-01-0525 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-0525 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-125 69% ...

  11. NCBI nr-aa BLAST: CBRC-SARA-01-0675 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SARA-01-0675 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-136 76% ...

  12. NCBI nr-aa BLAST: CBRC-LAFR-01-2829 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-2829 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-137 78% ...

  13. NCBI nr-aa BLAST: CBRC-EEUR-01-0625 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-0625 ref|NP_667047.1| olfactory receptor 1132 [Mus musculus] gb|AAL60920.1| olfactory... receptor MOR177-1 [Mus musculus] gb|AAP71551.1| olfactory receptor Olfr1132 [Mus musculus] emb|CAM25126.1| olfactory... receptor 1132 [Mus musculus] gb|EDL27401.1| olfactory receptor 1132 [Mus musculus] NP_667047.1 1e-135 75% ...

  14. NCBI nr-aa BLAST: CBRC-STRI-01-1441 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-STRI-01-1441 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 1e-110 78% ...

  15. NCBI nr-aa BLAST: CBRC-DNOV-01-1203 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-1203 ref|NP_667192.1| olfactory receptor 1260 [Mus musculus] gb|AAL60770.1| olfactory... receptor MOR232-2 [Mus musculus] gb|AAP71654.1| olfactory receptor Olfr1260 [Mus musculus] emb|CAM27664.1| olfactory... receptor 1260 [Mus musculus] gb|EDL27466.1| olfactory receptor 1260 [Mus musculus] NP_667192.1 1e-130 74% ...

  16. NCBI nr-aa BLAST: CBRC-CPOR-01-1606 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CPOR-01-1606 ref|NP_666644.1| olfactory receptor 994 [Mus musculus] gb|AAL61328.1| olfactory... receptor MOR203-4 [Mus musculus] gb|AAP71452.1| olfactory receptor Olfr994 [Mus musculus] emb|CAM24031.1| olfactory... receptor 994 [Mus musculus] gb|EDL27328.1| olfactory receptor 994 [Mus musculus] NP_666644.1 1e-140 79% ...

  17. NCBI nr-aa BLAST: CBRC-ETEL-01-0986 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0986 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 2e-84 65% ...

  18. NCBI nr-aa BLAST: CBRC-MMUS-02-0138 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0138 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-136 76% ...

  19. NCBI nr-aa BLAST: CBRC-GGOR-01-0347 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GGOR-01-0347 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 2e-69 81% ...

  20. NCBI nr-aa BLAST: CBRC-OPRI-01-0959 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OPRI-01-0959 ref|NP_666854.1| olfactory receptor 1155 [Mus musculus] gb|AAL61117.1| olfactory... receptor MOR174-10 [Mus musculus] gb|AAP71568.1| olfactory receptor Olfr1155 [Mus musculus] emb|CAM18637.1| olfactory... receptor 1155 [Mus musculus] gb|EDL27414.1| olfactory receptor 1155 [Mus musculus] NP_666854.1 2e-79 56% ...

  1. NCBI nr-aa BLAST: CBRC-MMUS-02-0023 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0023 ref|NP_667161.1| olfactory receptor 341 [Mus musculus] gb|AAL60801.1| olfactory... receptor MOR136-2 [Mus musculus] gb|AAP70875.1| olfactory receptor Olfr341 [Mus musculus] emb|CAM20475.1| olfactory... receptor 341 [Mus musculus] gb|EDL08679.1| olfactory receptor 341 [Mus musculus] NP_667161.1 1e-177 100% ...

  2. NCBI nr-aa BLAST: CBRC-DNOV-01-0483 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-0483 ref|NP_667122.1| olfactory receptor 1377 [Mus musculus] gb|AAL60840.1| olfactory... receptor MOR129-1 [Mus musculus] gb|AAP71759.1| olfactory receptor Olfr1377 [Mus musculus] emb|CAI35307.1| olfactory... receptor 1377 [Mus musculus] gb|EDL33683.1| olfactory receptor 1377 [Mus musculus] NP_667122.1 1e-140 79% ...

  3. NCBI nr-aa BLAST: CBRC-OCUN-01-0578 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OCUN-01-0578 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 1e-154 90% ...

  4. NCBI nr-aa BLAST: CBRC-OLAT-18-0035 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OLAT-18-0035 ref|NP_667161.1| olfactory receptor 341 [Mus musculus] gb|AAL60801.1| olfactory... receptor MOR136-2 [Mus musculus] gb|AAP70875.1| olfactory receptor Olfr341 [Mus musculus] emb|CAM20475.1| olfactory... receptor 341 [Mus musculus] gb|EDL08679.1| olfactory receptor 341 [Mus musculus] NP_667161.1 4e-04 24% ...

  5. NCBI nr-aa BLAST: CBRC-DNOV-01-1645 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-1645 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 1e-117 66% ...

  6. NCBI nr-aa BLAST: CBRC-FCAT-01-0108 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FCAT-01-0108 ref|NP_667047.1| olfactory receptor 1132 [Mus musculus] gb|AAL60920.1| olfactory... receptor MOR177-1 [Mus musculus] gb|AAP71551.1| olfactory receptor Olfr1132 [Mus musculus] emb|CAM25126.1| olfactory... receptor 1132 [Mus musculus] gb|EDL27401.1| olfactory receptor 1132 [Mus musculus] NP_667047.1 4e-59 77% ...

  7. NCBI nr-aa BLAST: CBRC-PCAP-01-0810 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PCAP-01-0810 ref|NP_667230.1| olfactory receptor 1054 [Mus musculus] gb|AAL60732.1| olfactory... receptor MOR188-2 [Mus musculus] gb|AAP71498.1| olfactory receptor Olfr1054 [Mus musculus] emb|CAM17888.1| olfactory... receptor 1054 [Mus musculus] gb|EDL27363.1| olfactory receptor 1054 [Mus musculus] NP_667230.1 1e-101 62% ...

  8. NCBI nr-aa BLAST: CBRC-LAFR-01-3876 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-3876 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 5e-60 58% ...

  9. NCBI nr-aa BLAST: CBRC-OPRI-01-1221 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OPRI-01-1221 ref|NP_666646.1| olfactory receptor 993 [Mus musculus] gb|AAL61326.1| olfactory... receptor MOR203-2 [Mus musculus] gb|AAP71451.1| olfactory receptor Olfr993 [Mus musculus] emb|CAM24030.1| olfactory... receptor 993 [Mus musculus] gb|EDL27327.1| olfactory receptor 993 [Mus musculus] NP_666646.1 1e-139 77% ...

  10. NCBI nr-aa BLAST: CBRC-LAFR-01-4115 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-4115 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 1e-130 73% ...

  11. NCBI nr-aa BLAST: CBRC-DNOV-01-0016 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-0016 ref|NP_667088.1| olfactory receptor 1395 [Mus musculus] gb|AAL60876.1| olfactory... receptor MOR277-1 [Mus musculus] gb|AAP71777.1| olfactory receptor Olfr1395 [Mus musculus] emb|CAM46261.1| olfactory... receptor 1395 [Mus musculus] gb|EDL33774.1| olfactory receptor 1395 [Mus musculus] NP_667088.1 1e-127 87% ...

  12. NCBI nr-aa BLAST: CBRC-EEUR-01-1536 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-1536 ref|NP_667122.1| olfactory receptor 1377 [Mus musculus] gb|AAL60840.1| olfactory... receptor MOR129-1 [Mus musculus] gb|AAP71759.1| olfactory receptor Olfr1377 [Mus musculus] emb|CAI35307.1| olfactory... receptor 1377 [Mus musculus] gb|EDL33683.1| olfactory receptor 1377 [Mus musculus] NP_667122.1 4e-78 76% ...

  13. NCBI nr-aa BLAST: CBRC-GGOR-01-1194 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GGOR-01-1194 ref|NP_666646.1| olfactory receptor 993 [Mus musculus] gb|AAL61326.1| olfactory... receptor MOR203-2 [Mus musculus] gb|AAP71451.1| olfactory receptor Olfr993 [Mus musculus] emb|CAM24030.1| olfactory... receptor 993 [Mus musculus] gb|EDL27327.1| olfactory receptor 993 [Mus musculus] NP_666646.1 1e-110 67% ...

  14. NCBI nr-aa BLAST: CBRC-TBEL-01-0332 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TBEL-01-0332 ref|NP_666507.1| olfactory receptor 1276 [Mus musculus] gb|AAL61363.1| olfactory... receptor MOR245-10 [Mus musculus] gb|AAP71670.1| olfactory receptor Olfr1276 [Mus musculus] emb|CAM27563.1| olfactory... receptor 1276 [Mus musculus] gb|EDL27803.1| olfactory receptor 1276 [Mus musculus] NP_666507.1 1e-98 77% ...

  15. NCBI nr-aa BLAST: CBRC-ETEL-01-0259 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0259 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 2e-67 69% ...

  16. NCBI nr-aa BLAST: CBRC-LAFR-01-3226 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-3226 ref|NP_666854.1| olfactory receptor 1155 [Mus musculus] gb|AAL61117.1| olfactory... receptor MOR174-10 [Mus musculus] gb|AAP71568.1| olfactory receptor Olfr1155 [Mus musculus] emb|CAM18637.1| olfactory... receptor 1155 [Mus musculus] gb|EDL27414.1| olfactory receptor 1155 [Mus musculus] NP_666854.1 1e-110 77% ...

  17. NCBI nr-aa BLAST: CBRC-PHAM-01-0915 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PHAM-01-0915 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-147 82% ...

  18. NCBI nr-aa BLAST: CBRC-CJAC-01-0213 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CJAC-01-0213 ref|NP_667058.1| olfactory receptor 1090 [Mus musculus] gb|AAL60909.1| olfactory... receptor MOR188-4 [Mus musculus] gb|AAP71517.1| olfactory receptor Olfr1090 [Mus musculus] emb|CAM24652.1| olfactory... receptor 1090 [Mus musculus] gb|EDL27371.1| olfactory receptor 1090 [Mus musculus] NP_667058.1 1e-140 77% ...

  19. NCBI nr-aa BLAST: CBRC-BTAU-01-0079 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-0079 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-137 75% ...

  20. NCBI nr-aa BLAST: CBRC-EEUR-01-0091 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-0091 ref|NP_667151.1| olfactory receptor 352 [Mus musculus] gb|AAL60811.1| olfactory... receptor MOR136-10 [Mus musculus] gb|AAP70886.1| olfactory receptor Olfr352 [Mus musculus] emb|CAM16518.1| olfactory... receptor 352 [Mus musculus] gb|EDL08690.1| olfactory receptor 352 [Mus musculus] NP_667151.1 2e-70 75% ...

  1. NCBI nr-aa BLAST: CBRC-LAFR-01-1124 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-1124 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-136 75% ...

  2. NCBI nr-aa BLAST: CBRC-TBEL-01-2547 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TBEL-01-2547 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-138 77% ...

  3. NCBI nr-aa BLAST: CBRC-DNOV-01-0762 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-0762 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 1e-126 67% ...

  4. NCBI nr-aa BLAST: CBRC-BTAU-01-0513 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-0513 ref|NP_666854.1| olfactory receptor 1155 [Mus musculus] gb|AAL61117.1| olfactory... receptor MOR174-10 [Mus musculus] gb|AAP71568.1| olfactory receptor Olfr1155 [Mus musculus] emb|CAM18637.1| olfactory... receptor 1155 [Mus musculus] gb|EDL27414.1| olfactory receptor 1155 [Mus musculus] NP_666854.1 1e-125 77% ...

  5. NCBI nr-aa BLAST: CBRC-LAFR-01-4023 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-4023 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-137 75% ...

  6. NCBI nr-aa BLAST: CBRC-BTAU-01-0483 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-0483 ref|NP_666854.1| olfactory receptor 1155 [Mus musculus] gb|AAL61117.1| olfactory... receptor MOR174-10 [Mus musculus] gb|AAP71568.1| olfactory receptor Olfr1155 [Mus musculus] emb|CAM18637.1| olfactory... receptor 1155 [Mus musculus] gb|EDL27414.1| olfactory receptor 1155 [Mus musculus] NP_666854.1 1e-125 77% ...

  7. NCBI nr-aa BLAST: CBRC-CJAC-01-0312 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CJAC-01-0312 ref|NP_666646.1| olfactory receptor 993 [Mus musculus] gb|AAL61326.1| olfactory... receptor MOR203-2 [Mus musculus] gb|AAP71451.1| olfactory receptor Olfr993 [Mus musculus] emb|CAM24030.1| olfactory... receptor 993 [Mus musculus] gb|EDL27327.1| olfactory receptor 993 [Mus musculus] NP_666646.1 1e-137 77% ...

  8. NCBI nr-aa BLAST: CBRC-CPOR-01-1270 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CPOR-01-1270 ref|NP_667058.1| olfactory receptor 1090 [Mus musculus] gb|AAL60909.1| olfactory... receptor MOR188-4 [Mus musculus] gb|AAP71517.1| olfactory receptor Olfr1090 [Mus musculus] emb|CAM24652.1| olfactory... receptor 1090 [Mus musculus] gb|EDL27371.1| olfactory receptor 1090 [Mus musculus] NP_667058.1 1e-106 62% ...

  9. NCBI nr-aa BLAST: CBRC-MEUG-01-0090 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MEUG-01-0090 ref|NP_666644.1| olfactory receptor 994 [Mus musculus] gb|AAL61328.1| olfactory... receptor MOR203-4 [Mus musculus] gb|AAP71452.1| olfactory receptor Olfr994 [Mus musculus] emb|CAM24031.1| olfactory... receptor 994 [Mus musculus] gb|EDL27328.1| olfactory receptor 994 [Mus musculus] NP_666644.1 2e-30 65% ...

  10. NCBI nr-aa BLAST: CBRC-PCAP-01-1410 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PCAP-01-1410 ref|NP_667151.1| olfactory receptor 352 [Mus musculus] gb|AAL60811.1| olfactory... receptor MOR136-10 [Mus musculus] gb|AAP70886.1| olfactory receptor Olfr352 [Mus musculus] emb|CAM16518.1| olfactory... receptor 352 [Mus musculus] gb|EDL08690.1| olfactory receptor 352 [Mus musculus] NP_667151.1 1e-134 78% ...

  11. NCBI nr-aa BLAST: CBRC-BTAU-01-2747 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-2747 ref|NP_666646.1| olfactory receptor 993 [Mus musculus] gb|AAL61326.1| olfactory... receptor MOR203-2 [Mus musculus] gb|AAP71451.1| olfactory receptor Olfr993 [Mus musculus] emb|CAM24030.1| olfactory... receptor 993 [Mus musculus] gb|EDL27327.1| olfactory receptor 993 [Mus musculus] NP_666646.1 1e-133 76% ...

  12. NCBI nr-aa BLAST: CBRC-DNOV-01-3176 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-3176 ref|NP_667192.1| olfactory receptor 1260 [Mus musculus] gb|AAL60770.1| olfactory... receptor MOR232-2 [Mus musculus] gb|AAP71654.1| olfactory receptor Olfr1260 [Mus musculus] emb|CAM27664.1| olfactory... receptor 1260 [Mus musculus] gb|EDL27466.1| olfactory receptor 1260 [Mus musculus] NP_667192.1 1e-136 76% ...

  13. NCBI nr-aa BLAST: CBRC-CPOR-01-0795 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CPOR-01-0795 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 4e-74 52% ...

  14. NCBI nr-aa BLAST: CBRC-MMUR-01-0402 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUR-01-0402 ref|NP_667088.1| olfactory receptor 1395 [Mus musculus] gb|AAL60876.1| olfactory... receptor MOR277-1 [Mus musculus] gb|AAP71777.1| olfactory receptor Olfr1395 [Mus musculus] emb|CAM46261.1| olfactory... receptor 1395 [Mus musculus] gb|EDL33774.1| olfactory receptor 1395 [Mus musculus] NP_667088.1 5e-32 80% ...

  15. NCBI nr-aa BLAST: CBRC-MMUS-02-0339 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0339 ref|NP_666507.1| olfactory receptor 1276 [Mus musculus] gb|AAL61363.1| olfactory... receptor MOR245-10 [Mus musculus] gb|AAP71670.1| olfactory receptor Olfr1276 [Mus musculus] emb|CAM27563.1| olfactory... receptor 1276 [Mus musculus] gb|EDL27803.1| olfactory receptor 1276 [Mus musculus] NP_666507.1 1e-135 76% ...

  16. NCBI nr-aa BLAST: CBRC-RNOR-03-0025 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-03-0025 ref|NP_667161.1| olfactory receptor 341 [Mus musculus] gb|AAL60801.1| olfactory... receptor MOR136-2 [Mus musculus] gb|AAP70875.1| olfactory receptor Olfr341 [Mus musculus] emb|CAM20475.1| olfactory... receptor 341 [Mus musculus] gb|EDL08679.1| olfactory receptor 341 [Mus musculus] NP_667161.1 1e-150 84% ...

  17. NCBI nr-aa BLAST: CBRC-MDOM-05-0203 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MDOM-05-0203 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 1e-148 83% ...

  18. NCBI nr-aa BLAST: CBRC-LAFR-01-2874 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-2874 ref|NP_667230.1| olfactory receptor 1054 [Mus musculus] gb|AAL60732.1| olfactory... receptor MOR188-2 [Mus musculus] gb|AAP71498.1| olfactory receptor Olfr1054 [Mus musculus] emb|CAM17888.1| olfactory... receptor 1054 [Mus musculus] gb|EDL27363.1| olfactory receptor 1054 [Mus musculus] NP_667230.1 3e-83 60% ...

  19. NCBI nr-aa BLAST: CBRC-STRI-01-2296 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-STRI-01-2296 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-130 74% ...

  20. NCBI nr-aa BLAST: CBRC-SARA-01-0312 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SARA-01-0312 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-137 76% ...

  1. NCBI nr-aa BLAST: CBRC-LAFR-01-1398 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-1398 ref|NP_667151.1| olfactory receptor 352 [Mus musculus] gb|AAL60811.1| olfactory... receptor MOR136-10 [Mus musculus] gb|AAP70886.1| olfactory receptor Olfr352 [Mus musculus] emb|CAM16518.1| olfactory... receptor 352 [Mus musculus] gb|EDL08690.1| olfactory receptor 352 [Mus musculus] NP_667151.1 1e-133 78% ...

  2. NCBI nr-aa BLAST: CBRC-LAFR-01-4024 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-4024 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 1e-133 75% ...

  3. NCBI nr-aa BLAST: CBRC-MMUS-02-0041 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0041 ref|NP_666480.1| olfactory receptor 361 [Mus musculus] gb|AAL61388.1| olfactory... receptor MOR159-3 [Mus musculus] gb|AAP70894.1| olfactory receptor Olfr361 [Mus musculus] emb|CAM20133.1| olfactory... receptor 361 [Mus musculus] gb|EDL08698.1| olfactory receptor 361 [Mus musculus] NP_666480.1 1e-142 84% ...

  4. NCBI nr-aa BLAST: CBRC-LAFR-01-3501 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-3501 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-117 67% ...

  5. NCBI nr-aa BLAST: CBRC-FCAT-01-0901 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FCAT-01-0901 ref|NP_666507.1| olfactory receptor 1276 [Mus musculus] gb|AAL61363.1| olfactory... receptor MOR245-10 [Mus musculus] gb|AAP71670.1| olfactory receptor Olfr1276 [Mus musculus] emb|CAM27563.1| olfactory... receptor 1276 [Mus musculus] gb|EDL27803.1| olfactory receptor 1276 [Mus musculus] NP_666507.1 1e-140 79% ...

  6. NCBI nr-aa BLAST: CBRC-SARA-01-1437 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SARA-01-1437 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-123 71% ...

  7. NCBI nr-aa BLAST: CBRC-ETEL-01-0939 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0939 ref|NP_667192.1| olfactory receptor 1260 [Mus musculus] gb|AAL60770.1| olfactory... receptor MOR232-2 [Mus musculus] gb|AAP71654.1| olfactory receptor Olfr1260 [Mus musculus] emb|CAM27664.1| olfactory... receptor 1260 [Mus musculus] gb|EDL27466.1| olfactory receptor 1260 [Mus musculus] NP_667192.1 1e-139 76% ...

  8. NCBI nr-aa BLAST: CBRC-BTAU-01-0928 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-0928 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-123 71% ...

  9. NCBI nr-aa BLAST: CBRC-CJAC-01-0139 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CJAC-01-0139 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-140 81% ...

  10. NCBI nr-aa BLAST: CBRC-TBEL-01-0145 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TBEL-01-0145 ref|NP_666644.1| olfactory receptor 994 [Mus musculus] gb|AAL61328.1| olfactory... receptor MOR203-4 [Mus musculus] gb|AAP71452.1| olfactory receptor Olfr994 [Mus musculus] emb|CAM24031.1| olfactory... receptor 994 [Mus musculus] gb|EDL27328.1| olfactory receptor 994 [Mus musculus] NP_666644.1 1e-103 77% ...

  11. NCBI nr-aa BLAST: CBRC-PCAP-01-0835 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PCAP-01-0835 ref|NP_666644.1| olfactory receptor 994 [Mus musculus] gb|AAL61328.1| olfactory... receptor MOR203-4 [Mus musculus] gb|AAP71452.1| olfactory receptor Olfr994 [Mus musculus] emb|CAM24031.1| olfactory... receptor 994 [Mus musculus] gb|EDL27328.1| olfactory receptor 994 [Mus musculus] NP_666644.1 1e-137 78% ...

  12. NCBI nr-aa BLAST: CBRC-LAFR-01-4099 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-4099 ref|NP_666854.1| olfactory receptor 1155 [Mus musculus] gb|AAL61117.1| olfactory... receptor MOR174-10 [Mus musculus] gb|AAP71568.1| olfactory receptor Olfr1155 [Mus musculus] emb|CAM18637.1| olfactory... receptor 1155 [Mus musculus] gb|EDL27414.1| olfactory receptor 1155 [Mus musculus] NP_666854.1 1e-112 66% ...

  13. NCBI nr-aa BLAST: CBRC-RNOR-10-0083 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-10-0083 ref|NP_667122.1| olfactory receptor 1377 [Mus musculus] gb|AAL60840.1| olfactory... receptor MOR129-1 [Mus musculus] gb|AAP71759.1| olfactory receptor Olfr1377 [Mus musculus] emb|CAI35307.1| olfactory... receptor 1377 [Mus musculus] gb|EDL33683.1| olfactory receptor 1377 [Mus musculus] NP_667122.1 2e-98 73% ...

  14. NCBI nr-aa BLAST: CBRC-EEUR-01-1009 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-1009 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-149 83% ...

  15. NCBI nr-aa BLAST: CBRC-RNOR-03-0146 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-03-0146 ref|NP_667058.1| olfactory receptor 1090 [Mus musculus] gb|AAL60909.1| olfactory... receptor MOR188-4 [Mus musculus] gb|AAP71517.1| olfactory receptor Olfr1090 [Mus musculus] emb|CAM24652.1| olfactory... receptor 1090 [Mus musculus] gb|EDL27371.1| olfactory receptor 1090 [Mus musculus] NP_667058.1 1e-145 80% ...

  16. NCBI nr-aa BLAST: CBRC-RNOR-03-0217 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-03-0217 ref|NP_667047.1| olfactory receptor 1132 [Mus musculus] gb|AAL60920.1| olfactory... receptor MOR177-1 [Mus musculus] gb|AAP71551.1| olfactory receptor Olfr1132 [Mus musculus] emb|CAM25126.1| olfactory... receptor 1132 [Mus musculus] gb|EDL27401.1| olfactory receptor 1132 [Mus musculus] NP_667047.1 1e-153 88% ...

  17. NCBI nr-aa BLAST: CBRC-BTAU-01-2011 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-2011 ref|NP_667088.1| olfactory receptor 1395 [Mus musculus] gb|AAL60876.1| olfactory... receptor MOR277-1 [Mus musculus] gb|AAP71777.1| olfactory receptor Olfr1395 [Mus musculus] emb|CAM46261.1| olfactory... receptor 1395 [Mus musculus] gb|EDL33774.1| olfactory receptor 1395 [Mus musculus] NP_667088.1 1e-164 91% ...

  18. NCBI nr-aa BLAST: CBRC-RNOR-10-0087 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-10-0087 ref|NP_667122.1| olfactory receptor 1377 [Mus musculus] gb|AAL60840.1| olfactory... receptor MOR129-1 [Mus musculus] gb|AAP71759.1| olfactory receptor Olfr1377 [Mus musculus] emb|CAI35307.1| olfactory... receptor 1377 [Mus musculus] gb|EDL33683.1| olfactory receptor 1377 [Mus musculus] NP_667122.1 1e-155 86% ...

  19. NCBI nr-aa BLAST: CBRC-SARA-01-1238 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SARA-01-1238 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-116 72% ...

  20. NCBI nr-aa BLAST: CBRC-CPOR-01-0039 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CPOR-01-0039 ref|NP_667019.1| olfactory receptor 1240 [Mus musculus] gb|AAL60949.1| olfactory... receptor MOR231-8 [Mus musculus] gb|AAP71635.1| olfactory receptor Olfr1240 [Mus musculus] emb|CAM27922.1| olfactory... receptor 1240 [Mus musculus] gb|EDL27460.1| olfactory receptor 1240 [Mus musculus] NP_667019.1 1e-136 76% ...

  1. NCBI nr-aa BLAST: CBRC-STRI-01-1815 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-STRI-01-1815 ref|NP_666644.1| olfactory receptor 994 [Mus musculus] gb|AAL61328.1| olfactory... receptor MOR203-4 [Mus musculus] gb|AAP71452.1| olfactory receptor Olfr994 [Mus musculus] emb|CAM24031.1| olfactory... receptor 994 [Mus musculus] gb|EDL27328.1| olfactory receptor 994 [Mus musculus] NP_666644.1 1e-139 79% ...

  2. NCBI nr-aa BLAST: CBRC-EEUR-01-1209 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-1209 ref|NP_667088.1| olfactory receptor 1395 [Mus musculus] gb|AAL60876.1| olfactory... receptor MOR277-1 [Mus musculus] gb|AAP71777.1| olfactory receptor Olfr1395 [Mus musculus] emb|CAM46261.1| olfactory... receptor 1395 [Mus musculus] gb|EDL33774.1| olfactory receptor 1395 [Mus musculus] NP_667088.1 1e-101 58% ...

  3. NCBI nr-aa BLAST: CBRC-PCAP-01-1510 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PCAP-01-1510 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-117 69% ...

  4. NCBI nr-aa BLAST: CBRC-CFAM-18-0207 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CFAM-18-0207 ref|NP_667192.1| olfactory receptor 1260 [Mus musculus] gb|AAL60770.1| olfactory... receptor MOR232-2 [Mus musculus] gb|AAP71654.1| olfactory receptor Olfr1260 [Mus musculus] emb|CAM27664.1| olfactory... receptor 1260 [Mus musculus] gb|EDL27466.1| olfactory receptor 1260 [Mus musculus] NP_667192.1 1e-148 84% ...

  5. NCBI nr-aa BLAST: CBRC-EEUR-01-1434 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-1434 ref|NP_666507.1| olfactory receptor 1276 [Mus musculus] gb|AAL61363.1| olfactory... receptor MOR245-10 [Mus musculus] gb|AAP71670.1| olfactory receptor Olfr1276 [Mus musculus] emb|CAM27563.1| olfactory... receptor 1276 [Mus musculus] gb|EDL27803.1| olfactory receptor 1276 [Mus musculus] NP_666507.1 4e-49 82% ...

  6. NCBI nr-aa BLAST: CBRC-PTRO-27-0250 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PTRO-27-0250 ref|NP_666507.1| olfactory receptor 1276 [Mus musculus] gb|AAL61363.1| olfactory... receptor MOR245-10 [Mus musculus] gb|AAP71670.1| olfactory receptor Olfr1276 [Mus musculus] emb|CAM27563.1| olfactory... receptor 1276 [Mus musculus] gb|EDL27803.1| olfactory receptor 1276 [Mus musculus] NP_666507.1 1e-116 69% ...

  7. NCBI nr-aa BLAST: CBRC-RNOR-03-0360 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-03-0360 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 1e-148 84% ...

  8. NCBI nr-aa BLAST: CBRC-MMUS-02-0123 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0123 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 1e-154 87% ...

  9. NCBI nr-aa BLAST: CBRC-MMUR-01-0611 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUR-01-0611 ref|NP_667088.1| olfactory receptor 1395 [Mus musculus] gb|AAL60876.1| olfactory... receptor MOR277-1 [Mus musculus] gb|AAP71777.1| olfactory receptor Olfr1395 [Mus musculus] emb|CAM46261.1| olfactory... receptor 1395 [Mus musculus] gb|EDL33774.1| olfactory receptor 1395 [Mus musculus] NP_667088.1 1e-101 59% ...

  10. NCBI nr-aa BLAST: CBRC-STRI-01-0227 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-STRI-01-0227 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 1e-146 85% ...

  11. NCBI nr-aa BLAST: CBRC-MMUS-02-0150 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0150 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-133 74% ...

  12. NCBI nr-aa BLAST: CBRC-PABE-12-0068 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PABE-12-0068 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 1e-139 81% ...

  13. NCBI nr-aa BLAST: CBRC-CFAM-18-0201 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CFAM-18-0201 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-146 81% ...

  14. NCBI nr-aa BLAST: CBRC-STRI-01-0445 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-STRI-01-0445 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-118 69% ...

  15. NCBI nr-aa BLAST: CBRC-MMUS-02-0028 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0028 ref|NP_667161.1| olfactory receptor 341 [Mus musculus] gb|AAL60801.1| olfactory... receptor MOR136-2 [Mus musculus] gb|AAP70875.1| olfactory receptor Olfr341 [Mus musculus] emb|CAM20475.1| olfactory... receptor 341 [Mus musculus] gb|EDL08679.1| olfactory receptor 341 [Mus musculus] NP_667161.1 1e-148 84% ...

  16. NCBI nr-aa BLAST: CBRC-DNOV-01-2646 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-2646 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 1e-117 73% ...

  17. NCBI nr-aa BLAST: CBRC-LAFR-01-1224 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-1224 ref|NP_667151.1| olfactory receptor 352 [Mus musculus] gb|AAL60811.1| olfactory... receptor MOR136-10 [Mus musculus] gb|AAP70886.1| olfactory receptor Olfr352 [Mus musculus] emb|CAM16518.1| olfactory... receptor 352 [Mus musculus] gb|EDL08690.1| olfactory receptor 352 [Mus musculus] NP_667151.1 1e-130 81% ...

  18. NCBI nr-aa BLAST: CBRC-RNOR-03-0043 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-03-0043 ref|NP_666480.1| olfactory receptor 361 [Mus musculus] gb|AAL61388.1| olfactory... receptor MOR159-3 [Mus musculus] gb|AAP70894.1| olfactory receptor Olfr361 [Mus musculus] emb|CAM20133.1| olfactory... receptor 361 [Mus musculus] gb|EDL08698.1| olfactory receptor 361 [Mus musculus] NP_666480.1 1e-153 85% ...

  19. NCBI nr-aa BLAST: CBRC-LAFR-01-3900 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-3900 ref|NP_667047.1| olfactory receptor 1132 [Mus musculus] gb|AAL60920.1| olfactory... receptor MOR177-1 [Mus musculus] gb|AAP71551.1| olfactory receptor Olfr1132 [Mus musculus] emb|CAM25126.1| olfactory... receptor 1132 [Mus musculus] gb|EDL27401.1| olfactory receptor 1132 [Mus musculus] NP_667047.1 1e-135 78% ...

  20. NCBI nr-aa BLAST: CBRC-RNOR-03-0168 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-03-0168 ref|NP_667058.1| olfactory receptor 1090 [Mus musculus] gb|AAL60909.1| olfactory... receptor MOR188-4 [Mus musculus] gb|AAP71517.1| olfactory receptor Olfr1090 [Mus musculus] emb|CAM24652.1| olfactory... receptor 1090 [Mus musculus] gb|EDL27371.1| olfactory receptor 1090 [Mus musculus] NP_667058.1 1e-166 93% ...

  1. NCBI nr-aa BLAST: CBRC-RNOR-10-0097 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-10-0097 ref|NP_667088.1| olfactory receptor 1395 [Mus musculus] gb|AAL60876.1| olfactory... receptor MOR277-1 [Mus musculus] gb|AAP71777.1| olfactory receptor Olfr1395 [Mus musculus] emb|CAM46261.1| olfactory... receptor 1395 [Mus musculus] gb|EDL33774.1| olfactory receptor 1395 [Mus musculus] NP_667088.1 1e-102 61% ...

  2. NCBI nr-aa BLAST: CBRC-LAFR-01-4104 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-4104 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 1e-135 76% ...

  3. Impact of Utilizing Pharmacy Students as Workforce for Hawai‘i Asthma Friendly Pharmacy Project

    OpenAIRE

    Ma, Carolyn S; Nett, Blythe; Kishaba, Gregg; Gomez, Lara

    2015-01-01

    A partnership was formed between the University of Hawai‘i at Hilo Daniel K. Inouye College of Pharmacy (DKICP) and the Department of Health to carry out the Hawai‘i Asthma Friendly Pharmacy Project (HAFPP), which utilizes pharmacy students as a workforce to administer Asthma Control Tests™ (ACT), and provide Asthma Action Plans (AAP) and inhaler technique education. Evaluation of data from a pilot project in 2008 with first and second year students prompted more intensive training in therape...

  4. Droplet Microfluidic Technique for the Study of Fermentation

    OpenAIRE

    Krzysztof Churski; Artur Ruszczak; Slawomir Jakiela; Piotr Garstecki

    2015-01-01

    We demonstrate a technique that uses microdroplets for culturing and selecting bacterial cultures in a model biotechnological application. We propose an assay for determination of ethanol concentration that provides increased dynamic range and is compatible with droplet microfluidic screening technologies. The assay comprises two enzymes—alcohol oxidase (AOX) and horseradish peroxidase (HRP)—and a colorimetric readout system of phenol-4-sulfonic acid (PSA) and 4-aminoantipyrine (4-AAP). The m...

  5. Esiplaanil heli / Harri Slip

    Index Scriptorium Estoniae

    Slip, Harri

    2015-01-01

    Kõrvaklapid hinnaga alla 200 €: AKG Y50BT, Audio-Technica, Beyerdynamic Custom Street, Bose SoundTrue around-ear II, Creative Aurvana Gold, Denon AH-MM200, Focal Spirit One S, Grado SR 80e, JBL Everest V300, Klipsch Reference On Ear, Panasonic RP-HD10, Philips SHB8850NC, Sennheiser HD 25, SMS Audio On-Ear Wired Sport, Sony MDR-100AAP

  6. Novel parvoviruses in reptiles and genome sequence of a lizard parvovirus shed light on Dependoparvovirus genus evolution.

    Science.gov (United States)

    Pénzes, Judit J; Pham, Hanh T; Benkö, Mária; Tijssen, Peter

    2015-09-01

    Here, we report the detection and partial genome characterization of two novel reptilian parvoviruses derived from a short-tailed pygmy chameleon (Rampholeon brevicaudatus) and a corn snake (Pantherophis guttatus) along with the complete genome analysis of the first lizard parvovirus, obtained from four bearded dragons (Pogona vitticeps). Both homology searches and phylogenetic tree reconstructions demonstrated that all are members of the genus Dependoparvovirus. Even though most dependoparvoviruses replicate efficiently only in co-infections with large DNA viruses, no such agents could be detected in one of the bearded dragon samples, hence the possibility of autonomous replication was explored. The alternative ORF encoding the full assembly activating protein (AAP), typical for the genus, could be obtained from reptilian parvoviruses for the first time, with a structure that appears to be more ancient than that of avian and mammalian parvoviruses. All three viruses were found to harbour short introns as previously observed for snake adeno-associated virus, shorter than that of any non-reptilian dependoparvovirus. According to the phylogenetic calculations based on full non-structural protein (Rep) and AAP sequences, the monophyletic cluster of reptilian parvoviruses seems to be the most basal out of all lineages of genus Dependoparvovirus. The suspected ability for autonomous replication, results of phylogenetic tree reconstruction, intron lengths and the structure of the AAP suggested that a single Squamata origin instead of the earlier assumed diapsid (common avian-reptilian) origin is more likely for the genus Dependoparvovirus of the family Parvoviridae.

  7. Assessing the treatment of acetaminophen-contaminated brewery wastewater by an anaerobic packed-bed reactor.

    Science.gov (United States)

    Abdullah, Norhayati; Fulazzaky, Mohamad Ali; Yong, Ee Ling; Yuzir, Ali; Sallis, Paul

    2016-03-01

    The treatment of high-strength organic brewery wastewater with added acetaminophen (AAP) by an anaerobic digester was investigated. An anaerobic packed-bed reactor (APBR) was operated as a continuous process with an organic loading rate of 1.5-g COD per litre per day and a hydraulic retention time of three days. The results of steady-state analysis showed that the greatest APBR performances for removing COD and TOC were as high as 98 and 93%, respectively, even though the anaerobic digestibility after adding the different AAP concentrations of 5, 10 and 15 mg L(-1) into brewery wastewater can affect the efficiency of organic matter removal. The average CH4 production decreased from 81 to 72% is counterbalanced by the increased CO2 production from 11 to 20% before and after the injection of AAP, respectively. The empirical kinetic models for substrate utilisation and CH4 production were used to predict that, under unfavourable conditions, the performance of the APBR treatment process is able to remove COD with an efficiency of only 6.8%. PMID:26760229

  8. Novel parvoviruses in reptiles and genome sequence of a lizard parvovirus shed light on Dependoparvovirus genus evolution.

    Science.gov (United States)

    Pénzes, Judit J; Pham, Hanh T; Benkö, Mária; Tijssen, Peter

    2015-09-01

    Here, we report the detection and partial genome characterization of two novel reptilian parvoviruses derived from a short-tailed pygmy chameleon (Rampholeon brevicaudatus) and a corn snake (Pantherophis guttatus) along with the complete genome analysis of the first lizard parvovirus, obtained from four bearded dragons (Pogona vitticeps). Both homology searches and phylogenetic tree reconstructions demonstrated that all are members of the genus Dependoparvovirus. Even though most dependoparvoviruses replicate efficiently only in co-infections with large DNA viruses, no such agents could be detected in one of the bearded dragon samples, hence the possibility of autonomous replication was explored. The alternative ORF encoding the full assembly activating protein (AAP), typical for the genus, could be obtained from reptilian parvoviruses for the first time, with a structure that appears to be more ancient than that of avian and mammalian parvoviruses. All three viruses were found to harbour short introns as previously observed for snake adeno-associated virus, shorter than that of any non-reptilian dependoparvovirus. According to the phylogenetic calculations based on full non-structural protein (Rep) and AAP sequences, the monophyletic cluster of reptilian parvoviruses seems to be the most basal out of all lineages of genus Dependoparvovirus. The suspected ability for autonomous replication, results of phylogenetic tree reconstruction, intron lengths and the structure of the AAP suggested that a single Squamata origin instead of the earlier assumed diapsid (common avian-reptilian) origin is more likely for the genus Dependoparvovirus of the family Parvoviridae. PMID:26067293

  9. Oxytocin enhances the experience of attachment security

    Science.gov (United States)

    Buchheim, Anna; Heinrichs, Markus; George, Carol; Pokorny, Dan; Koops, Eva; Henningsen, Peter; O’Connor, Mary-Frances; Gundel, Harald

    2011-01-01

    Summary Repeated interactions between infant and caregiver result in either secure or insecure relationship attachment patterns, and insecure attachment may affect individual emotion-regulation and health. Given that oxytocin enhances social approach behavior in animals and humans, we hypothesized that oxytocin might also promote the experience of attachment security in humans. Within a 3-week interval 26 healthy male students classified with an insecure attachment pattern were invited twice to an experimental session. Within each session, a single dose of oxytocin or placebo was administered, using a double-blind, placebo-controlled within-subject design. In both conditions, subjects completed an attachment task based on the Adult Attachment Projective Picture System (AAP). Thirty-two AAP picture system presentations depicted attachment-related events (e.g. illness, solitude, separation, loss), and were each accompanied by four prototypical phrases representing one secure and three insecure attachment categories. In the oxytocin condition, a significant proportion of these insecure subjects (N = 18; 69%) changed their rankings of “secure attachment” phrases towards the more appropriate for the AAP picture presentation, and the same subjects decreased in overall rating of the “insecure attachment” phrases. In particular, there was a significant decrease in the number of subjects ranking the pictures with “insecure-preoccupied” phrases from the placebo to the oxytocin condition. We find that a single dose of intranasally administered oxytocin is sufficient to induce a significant increase in the experience of attachment security in adults classified previously as insecure. PMID:19457618

  10. Media use by children younger than 2 years.

    Science.gov (United States)

    Brown, Ari

    2011-11-01

    In 1999, the American Academy of Pediatrics (AAP) issued a policy statement addressing media use in children. The purpose of that statement was to educate parents about the effects that media--both the amount and the content--may have on children. In one part of that statement, the AAP recommended that "pediatricians should urge parents to avoid television viewing for children under the age of two years." The wording of the policy specifically discouraged media use in this age group, although it is frequently misquoted by media outlets as no media exposure in this age group. The AAP believed that there were significantly more potential negative effects of media than positive ones for this age group and, thus, advised families to thoughtfully consider media use for infants. This policy statement reaffirms the 1999 statement with respect to media use in infants and children younger than 2 years and provides updated research findings to support it. This statement addresses (1) the lack of evidence supporting educational or developmental benefits for media use by children younger than 2 years, (2) the potential adverse health and developmental effects of media use by children younger than 2 years, and (3) adverse effects of parental media use (background media) on children younger than 2 years.

  11. Proximate and elemental analysis of infant formula.

    Science.gov (United States)

    Tanner, J T

    1982-11-01

    The Nutrient Surveillance Branch has been conducting a survey of infant formula products for Fiscal Year 1981. Each product has been carefully analyzed and the results compared to the label declaration and the minimum-maximum limits specified by the American Academy of Pediatrics' Committee on Nutrition (CON/AAP). Proximate and elemental analyses were made. Protein, fat, ash, and total solids (moisture) were determined by AOAC methods. Osmolality, density, and fatty acids (linoleic) were also determined. Carbohydrates were calculated by difference and caloric content was calculated by using the general Atwater factors. Elemental analysis for Ca, P, Mg, Fe, Zn, Cu, Mn, Na, and K were performed by induction coupled plasma absorption spectroscopy. Chloride was assayed by potentiometric titration with AgNO3. A summary of the findings from the infant formula survey have been compared with CON/AAP recommendations. In general, there were only a few exceptions where the label claims and the CON/AAP requirements were not met. However, in none of these cases was the difference considered to be of public health significance.

  12. Serial Ultrasound Monitoring for Early Recognition of Asparaginase Associated Pancreatitis in Children With Acute Lymphoblastic Leukemia

    DEFF Research Database (Denmark)

    Raja, Raheel Altaf; Schmiegelow, K.; Henriksen, Birthe Merete;

    2015-01-01

    BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common cancer in children and L-asparaginase is an essential component of the treatment. Cessation of L-asparaginase decreases event free survival. Acute pancreatitis is the toxicity that most commonly results in cessation of L-asparagina......BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common cancer in children and L-asparaginase is an essential component of the treatment. Cessation of L-asparaginase decreases event free survival. Acute pancreatitis is the toxicity that most commonly results in cessation of L...... protocol, with PEG-asparaginase of 2 or 6 week intervals, for 30 weeks had their pancreas monitored using serial ultrasound in order to detect early signs of inflammation. RESULTS: Nineteen of 31 eligible patients were included. Three of the included patients developed AAP. None of the patients, including...... the three patients that developed AAP, had signs of inflammatory edema or pancreas enzymes above three times the upper normal limit prior to AAP. CONCLUSION: We found no signs of inflammatory edema within the pancreas on ultrasound during treatment with PEG-asparginase in our cohort prior to development...

  13. Impact of utilizing pharmacy students as workforce for Hawai'i Asthma Friendly Pharmacy Project.

    Science.gov (United States)

    Ma, Carolyn S; Nett, Blythe; Kishaba, Gregg; Gomez, Lara

    2015-02-01

    A partnership was formed between the University of Hawai'i at Hilo Daniel K. Inouye College of Pharmacy (DKICP) and the Department of Health to carry out the Hawai'i Asthma Friendly Pharmacy Project (HAFPP), which utilizes pharmacy students as a workforce to administer Asthma Control Tests™ (ACT), and provide Asthma Action Plans (AAP) and inhaler technique education. Evaluation of data from a pilot project in 2008 with first and second year students prompted more intensive training in therapeutics, inhaler medication training, and communication techniques. Data collection began when two classes of students were first and second year students and continued until the students became fourth year students in their advanced experiential ambulatory care clinic and retail community pharmacy rotations. Patients seen included pediatric (32%) and adult (68%) aged individuals. Hawai'i County was the most common geographic site (50%) and most sites were retail pharmacies (72%). Administered ACT surveys (N=96) yielded a mean score of 19.64 (SD +/-3.89). In addition, 12% of patients had received previous ACT, and 47% had previous AAPs. Approximately 83% of patients received an additional intervention of AAP and inhaler education with 73% of these patients able to demonstrate back proper inhaler technique. Project challenges included timing of student training, revising curriculum and logistics of scheduling students to ensure consistent access to patients.

  14. Medical Versus Nonmedical Immunization Exemptions for Child Care and School Attendance.

    Science.gov (United States)

    2016-09-01

    Routine childhood immunizations against infectious diseases are an integral part of our public health infrastructure. They provide direct protection to the immunized individual and indirect protection to children and adults unable to be immunized via the effect of community immunity. All 50 states, the District of Columbia, and Puerto Rico have regulations requiring proof of immunization for child care and school attendance as a public health strategy to protect children in these settings and to secondarily serve as a mechanism to promote timely immunization of children by their caregivers. Although all states and the District of Columbia have mechanisms to exempt school attendees from specific immunization requirements for medical reasons, the majority also have a heterogeneous collection of regulations and laws that allow nonmedical exemptions from childhood immunizations otherwise required for child care and school attendance. The American Academy of Pediatrics (AAP) supports regulations and laws requiring certification of immunization to attend child care and school as a sound means of providing a safe environment for attendees and employees of these settings. The AAP also supports medically indicated exemptions to specific immunizations as determined for each individual child. The AAP views nonmedical exemptions to school-required immunizations as inappropriate for individual, public health, and ethical reasons and advocates for their elimination. PMID:27573087

  15. Synthesis, characterization, antimicrobial screening and computational studies of 4-[3-(4-methoxy-phenyl)-allylideneamino]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one

    Science.gov (United States)

    Obasi, L. N.; Kaior, G. U.; Rhyman, L.; Alswaidan, Ibrahim A.; Fun, Hoong-Kun; Ramasami, P.

    2016-09-01

    The Schiff base, 4-[3-(4-methoxy-phenyl)-allylideneamino]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one (TPMC/AAP) was synthesized by the condensation of 4-aminoantipyrine (4-amino-1,5-dimethyl-2-phenylpyrazole-3-one) and trans-para-methoxycinnamaldehyde (trans-3,4-methoxyphenyl-2-propenal) in dry methanol at 75 °C. The compound was characterized using elemental microanalysis, IR, NMR, UV spectroscopies and single-crystal X-ray crystallography. The X-ray structure determination shows that the Schiff base, (TPMC/AAP) is orthorhombic with the Pbca space group. The anti-microbial screening of the compound was carried out with Escherichia coli, Bacillus subtillis, Staphylococcus aureus, Pseudemonas aeruginosa, Candida albicans and Aspergillus niger using agar well diffusion method. The Schiff base possesses significant antimicrobial activity. The minimum inhibitory concentration (MIC) of the compound was also determined and the activity was compared with that of conventional drugs ciprofloxacin and ketoconazole. The compound (TPMC/AAP) showed varying activity against the cultured bacteria and fungi used. To complement the experimental data, density functional theory (DFT) was used to have deeper understanding into the molecular parameters and infrared spectra of the compound.

  16. Promoting psychosocial adaptation of youths in residential care through animal-assisted psychotherapy.

    Science.gov (United States)

    Balluerka, Nekane; Muela, Alexander; Amiano, Nora; Caldentey, Miguel A

    2015-12-01

    The goal of this study was to examine the influence of animal-assisted psychotherapy (AAP) on the psychosocial adaptation of a group of adolescents in residential care who had suffered traumatic childhood experiences and who presented with mental health problems. This study recruited 63 youths (mean age=15.27, SD=1.63) who were divided into two groups: a treatment group of 39 youths (19 female and 20 male; mean age=15.03, SD=0.51) and a control group of 24 (five female and 19 male; mean age=15.67, SD=1.63). The youths who underwent the AAP program had higher school adjustment in comparison to their peers who did not receive treatment. Their hyperactive behavior decreased, and they showed better social skills, more leadership, and fewer attention problems. They also showed a more positive attitude toward their teachers in comparison to controls. No differences were observed in other variables associated with clinical symptoms or personal adjustment. These results suggest that AAP can be effective with teenagers who have suffered childhood traumas and who present with problems of psychosocial adaptation. PMID:26443670

  17. Binding of aromatic amines to the rat hepatic Ah receptor in vitro and in vivo and the 8S and 4S estrogen receptor of rat uterus and rat liver

    Energy Technology Data Exchange (ETDEWEB)

    Cikryt, P.; Kaiser, T.; Gottlicher, M. (Univ. of Wuerzburg (West Germany))

    1990-08-01

    Studies on structurally related aromatic amines with different carcinogenic properties have shown that 2-acetylaminofluorene (2-AAF) and 2-acetylaminophenanthrene (AAP) inhibit the binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the Ah receptor in vitro. The apparent inhibitor constants (K{sub i}) are 2.3 {mu}M for 2-AAF and 2.7 {mu}M for AAP. In contrast, 4-acetylaminofluorene, an isomer of 2-AAF, and trans-4-acetylaminostilbene do not bind to the rat hepatic cytosolic Ah receptor. Pretreating female Wistar rats with 2-AAF or AAP leads to the induction of the P-450 isoenzymes that are under the control of the Ah receptor. Ornithine decarboxylase activity is induced by all aromatic amines tested irrespective of their Ah receptor affinity. The aromatic amines used as model compounds do not inhibit the binding of 17-{beta}-estradiol to the 8S and 4S estrogen receptor of rat uterus or rat liver in a competition assay analyzed using sucrose density gradient centrifugation. On the other hand, the aromatic amines bind to varying extents to another estrogen-binding protein of rat liver whose function and identity is still unknown. The study demonstrates that structurally related aromatic amines in their unmetabolized form interact differentially with a cellular target protein, the Ah receptor, in vitro as well as in vivo. However, a relationship between these effects and the postulated promoting properties of 2-AAF remains to be established.

  18. Experience in diagnosis and treatment of asparaginase-associated pancreatitis in children%门冬酰胺酶相关胰腺炎的诊治体会

    Institute of Scientific and Technical Information of China (English)

    陈再生; 李健

    2014-01-01

    Objective To analyze the clinical characteristics and the course of diagnosis and therapy of PEG-asparaginase associated pancreatitis (AAP)in childhood,and to reveal the pathophysiology of AAP,enhance the ability of diagnosis and treament.Method Data of 13 cases with AAP in childhood seen from March 2011 to March 2014 were analyzed with regard to clinical manifestations,laboratory findings,imaging feature and treatment.Result AAP was found in 12 of acute lymphoblastic leukemia (ALL) and 1 of non-Hodgkin's lymphoma (NHL),8 were boys and 5 were girls,with a mean age 6 years.In 12 cases AAP occurred during the induction-remission treatment,in 1 case during the maintenance-intensification phase.AAP occurred after a median of two doses,and 9 d (median) from the latest administration of PEG-asparaginase.The major manifestations of AAP was abdominal pain (11/13).At the time of AAP diagnosis during the first 48 hours the median peak serum amylase and serum lipase levels were 559 U/L (range 118 -1 585,upper normal limit:125) and 934 U/L (range 221-1 673,upper normal limit:300).Three cases with serum amylase and serum lipase levels above 3 times upper normal limit were repeatedly complicated with pancreatic pseudocyst; 11 patients had abnormal CT imaging,8 cases revealed effusion around the pancreas,and 4 cases had pseudocyst.Therapy with ulinastatin,octreotide acetate,glucocorticoid could relieve abdominal pain significantly.Three cases underwent abdominal puncture drainage and 5 cases fulfilled nasojejunal nutrition therapy.Nine of them were cured,4 developed pseudocyst,in 2 AAP vanished gradually and 2 died with pseudocyst.Conclusion The major manifestations of AAP were abdominal pain,but sometimes apparent and sometimes latent.Condition of acute pancreatitis may exacerbate rapidly and easily.Early identification had significance.Pancreatic pseudocyst suggested a poor prognosis.%目的 分析门冬酰胺酶相关胰腺炎(AAP)的临床特征和诊治经过.方法 收集

  19. Enzyme histochemical studies of membrane proteases in rat subfornical organ.

    Science.gov (United States)

    De Bault, L E; Mitro, A

    1994-12-01

    Localization of membrane proteases glutamyl aminopeptidase (EAP), microsomal alanyl aminopeptidase (mAAP), dipeptidyl peptidase IV (DPP IV) and gamma-glutamyl transpeptidase (gamma-GTP) were studied in vessels of the rat subfornical organ (SFO), ependyma which cover the surface of the SFO, and adjacent brain structures. Results of enzyme histochemical reactions showed strong activity for EAP, mAAP, and gamma-GTP, but absence of DPP IV in microvessels of SFO. The ependyma which cover the SFO was positive for gamma-GTP, but negative for other studied proteases. Our results showed that the spectrum of enzymes in the majority of the vessels of SFO is similar to that of the microvessels of the adjacent brain tissue which were positive for EAP, mAAP, and gamma-GTP, but negative for DPP IV. The relative intensity of the enzyme reactions in vessels varied from central to lateral locations in the SFO and the adjacent brain tissue. There was also a difference in the relative reaction intensity from one enzyme to the other. The presence and heterogeneous distribution of the enzymes are consistent with the hypothesis that membrane proteases of the microvascular endothelium constitute an enzyme-barrier between blood and parenchyma of the SFO and between blood and brain tissue, and may be involved in metabolism or modulation of various peptides when they contact the plasma membrane of the endothelial cells of the vessels.

  20. Health information technology and the medical home.

    Science.gov (United States)

    2011-05-01

    The American Academy of Pediatrics (AAP) supports development and universal implementation of a comprehensive electronic infrastructure to support pediatric information functions of the medical home. These functions include (1) timely and continuous management and tracking of health data and services over a patient's lifetime for all providers, patients, families, and guardians, (2) comprehensive organization and secure transfer of health data during patient-care transitions between providers, institutions, and practices, (3) establishment and maintenance of central coordination of a patient's health information among multiple repositories (including personal health records and information exchanges), (4) translation of evidence into actionable clinical decision support, and (5) reuse of archived clinical data for continuous quality improvement. The AAP supports universal, secure, and vendor-neutral portability of health information for all patients contained within the medical home across all care settings (ambulatory practices, inpatient settings, emergency departments, pharmacies, consultants, support service providers, and therapists) for multiple purposes including direct care, personal health records, public health, and registries. The AAP also supports financial incentives that promote the development of information tools that meet the needs of pediatric workflows and that appropriately recognize the added value of medical homes to pediatric care. PMID:21518710

  1. SIDS and other sleep-related infant deaths: expansion of recommendations for a safe infant sleeping environment.

    Science.gov (United States)

    Moon, Rachel Y

    2011-11-01

    Despite a major decrease in the incidence of sudden infant death syndrome (SIDS) since the American Academy of Pediatrics (AAP) released its recommendation in 1992 that infants be placed for sleep in a nonprone position, this decline has plateaued in recent years. Concurrently, other causes of sudden unexpected infant death that occur during sleep (sleep-related deaths), including suffocation, asphyxia, and entrapment, and ill-defined or unspecified causes of death have increased in incidence, particularly since the AAP published its last statement on SIDS in 2005. It has become increasingly important to address these other causes of sleep-related infant death. Many of the modifiable and nonmodifiable risk factors for SIDS and suffocation are strikingly similar. The AAP, therefore, is expanding its recommendations from focusing only on SIDS to focusing on a safe sleep environment that can reduce the risk of all sleep-related infant deaths, including SIDS. The recommendations described in this policy statement include supine positioning, use of a firm sleep surface, breastfeeding, room-sharing without bed-sharing, routine immunizations, consideration of using a pacifier, and avoidance of soft bedding, overheating, and exposure to tobacco smoke, alcohol, and illicit drugs. The rationale for these recommendations is discussed in detail in the accompanying "Technical Report--SIDS and Other Sleep-Related Infant Deaths: Expansion of Recommendations for a Safe Infant Sleeping Environment," which is included in this issue of Pediatrics (www.pediatrics.org/cgi/content/full/128/5/e1341).

  2. Acquisition, Replication and Inoculation of Candidatus Liberibacter asiaticus following Various Acquisition Periods on Huanglongbing-Infected Citrus by Nymphs and Adults of the Asian Citrus Psyllid.

    Science.gov (United States)

    Ammar, El-Desouky; Ramos, John E; Hall, David G; Dawson, William O; Shatters, Robert G

    2016-01-01

    The Asian citrus psyllid, Diaphorina citri (Hemiptera: Liviidae), is the primary vector of Candidatus Liberibacter asiaticus (Las) implicated as causative agent of citrus huanglongbing (citrus greening), currently the most serious citrus disease worldwide. Las is transmitted by D. citri in a persistent-circulative manner, but the question of replication of this bacterium in its psyllid vector has not been resolved. Thus, we studied the effects of the acquisition access period (AAP) by nymphs and adults of D. citri on Las acquisition, multiplication and inoculation/transmission. D. citri nymphs or adults (previously non-exposed to Las) were caged on Las-infected citrus plants for an AAP of 1, 7 or 14 days. These 'Las-exposed' psyllids were then transferred weekly to healthy citrus or orange jasmine plants, and sampled via quantitative polymerase chain reaction (qPCR) analysis 1-42 days post-first access to diseased plants (padp); all tested nymphs became adults 7-14 days padp. Our results indicate that following 1 or 7 day AAP as nymphs 49-59% of Las-exposed psyllids became Las-infected (qPCR-positive), whereas only 8-29% of the psyllids were infected following 1-14 day AAP as adults. Q-PCR analysis also indicated that Las titer in the Las-exposed psyllids (relative to that of the psyllid S20 ribosomal protein gene) was: 1) significantly higher, and increasing at a faster rate, following Las acquisition as nymphs compared to that following Las acquisition as adults; 2) higher as post-acquisition time of psyllids on healthy plants increased reaching a peak at 14-28 days padp for nymphs and 21-35 days padp for adults, with Las titer decreasing or fluctuating after that; 3) higher with longer AAP on infected plants, especially with acquisition as adults. Our results strongly suggest that Las multiplies in both nymphs and adults of D. citri but attains much higher levels in a shorter period of time post-acquisition when acquired by nymphs than when acquired by adults

  3. Ambient air pollution associated with suppressed serologic responses to Pneumocystis jirovecii in a prospective cohort of HIV-infected patients with Pneumocystis pneumonia.

    Directory of Open Access Journals (Sweden)

    Robert J Blount

    Full Text Available Ambient air pollution (AAP may be associated with increased risk for Pneumocystis pneumonia (PCP. The mechanisms underlying this association remain uncertain.To determine if real-life exposures to AAP are associated with suppressed IgM antibody responses to P. jirovecii in HIV-infected (HIV+ patients with active PCP, and to determine if AAP, mediated by suppressed serologic responses to Pneumocystis, is associated with adverse clinical outcomes.We conducted a prospective cohort study in HIV+ patients residing in San Francisco and admitted to San Francisco General Hospital with microscopically confirmed PCP. Our AAP predictors were ambient air concentrations of particulate matter of < 10 µm in diameter (PM10 and < 2.5 µm in diameter (PM2.5, nitrogen dioxide (NO2, ozone (O3, and sulfur dioxide (SO2 measured immediately prior to hospital admission and 2 weeks prior to admission. Our primary outcomes were the IgM serologic responses to four recombinant P. jirovecii major surface glycoprotein (Msg constructs: MsgC1, MsgC3, MsgC8, and MsgC9.Elevated PM10 and NO2 exposures immediately prior to and two weeks prior to hospital admission were associated with decreased IgM antibody responses to P. jirovecii Msg. For exposures immediately prior to admission, every 10 µg/m(3 increase in PM10 was associated with a 25 to 35% decrease in IgM responses to Msg (statistically significant for all the Msg constructs, and every 10 ppb increase in NO2 was associated with a 19-45% decrease in IgM responses to Msg (statistically significant for MsgC8 and MsgC9. Similar findings were seen with exposures two weeks prior to admission, but for fewer of the Msg constructs.Real life exposures to PM10 and NO2 were associated with suppressed IgM responses to P. jirovecii Msg in HIV+ patients admitted with PCP, suggesting a mechanism of immunotoxicity by which AAP increases host susceptibility to pulmonary infection.

  4. Acquisition, Replication and Inoculation of Candidatus Liberibacter asiaticus following Various Acquisition Periods on Huanglongbing-Infected Citrus by Nymphs and Adults of the Asian Citrus Psyllid.

    Directory of Open Access Journals (Sweden)

    El-Desouky Ammar

    Full Text Available The Asian citrus psyllid, Diaphorina citri (Hemiptera: Liviidae, is the primary vector of Candidatus Liberibacter asiaticus (Las implicated as causative agent of citrus huanglongbing (citrus greening, currently the most serious citrus disease worldwide. Las is transmitted by D. citri in a persistent-circulative manner, but the question of replication of this bacterium in its psyllid vector has not been resolved. Thus, we studied the effects of the acquisition access period (AAP by nymphs and adults of D. citri on Las acquisition, multiplication and inoculation/transmission. D. citri nymphs or adults (previously non-exposed to Las were caged on Las-infected citrus plants for an AAP of 1, 7 or 14 days. These 'Las-exposed' psyllids were then transferred weekly to healthy citrus or orange jasmine plants, and sampled via quantitative polymerase chain reaction (qPCR analysis 1-42 days post-first access to diseased plants (padp; all tested nymphs became adults 7-14 days padp. Our results indicate that following 1 or 7 day AAP as nymphs 49-59% of Las-exposed psyllids became Las-infected (qPCR-positive, whereas only 8-29% of the psyllids were infected following 1-14 day AAP as adults. Q-PCR analysis also indicated that Las titer in the Las-exposed psyllids (relative to that of the psyllid S20 ribosomal protein gene was: 1 significantly higher, and increasing at a faster rate, following Las acquisition as nymphs compared to that following Las acquisition as adults; 2 higher as post-acquisition time of psyllids on healthy plants increased reaching a peak at 14-28 days padp for nymphs and 21-35 days padp for adults, with Las titer decreasing or fluctuating after that; 3 higher with longer AAP on infected plants, especially with acquisition as adults. Our results strongly suggest that Las multiplies in both nymphs and adults of D. citri but attains much higher levels in a shorter period of time post-acquisition when acquired by nymphs than when acquired by

  5. Acquisition, Replication and Inoculation of Candidatus Liberibacter asiaticus following Various Acquisition Periods on Huanglongbing-Infected Citrus by Nymphs and Adults of the Asian Citrus Psyllid.

    Science.gov (United States)

    Ammar, El-Desouky; Ramos, John E; Hall, David G; Dawson, William O; Shatters, Robert G

    2016-01-01

    The Asian citrus psyllid, Diaphorina citri (Hemiptera: Liviidae), is the primary vector of Candidatus Liberibacter asiaticus (Las) implicated as causative agent of citrus huanglongbing (citrus greening), currently the most serious citrus disease worldwide. Las is transmitted by D. citri in a persistent-circulative manner, but the question of replication of this bacterium in its psyllid vector has not been resolved. Thus, we studied the effects of the acquisition access period (AAP) by nymphs and adults of D. citri on Las acquisition, multiplication and inoculation/transmission. D. citri nymphs or adults (previously non-exposed to Las) were caged on Las-infected citrus plants for an AAP of 1, 7 or 14 days. These 'Las-exposed' psyllids were then transferred weekly to healthy citrus or orange jasmine plants, and sampled via quantitative polymerase chain reaction (qPCR) analysis 1-42 days post-first access to diseased plants (padp); all tested nymphs became adults 7-14 days padp. Our results indicate that following 1 or 7 day AAP as nymphs 49-59% of Las-exposed psyllids became Las-infected (qPCR-positive), whereas only 8-29% of the psyllids were infected following 1-14 day AAP as adults. Q-PCR analysis also indicated that Las titer in the Las-exposed psyllids (relative to that of the psyllid S20 ribosomal protein gene) was: 1) significantly higher, and increasing at a faster rate, following Las acquisition as nymphs compared to that following Las acquisition as adults; 2) higher as post-acquisition time of psyllids on healthy plants increased reaching a peak at 14-28 days padp for nymphs and 21-35 days padp for adults, with Las titer decreasing or fluctuating after that; 3) higher with longer AAP on infected plants, especially with acquisition as adults. Our results strongly suggest that Las multiplies in both nymphs and adults of D. citri but attains much higher levels in a shorter period of time post-acquisition when acquired by nymphs than when acquired by adults

  6. Korean Medication Algorithm for Bipolar Disorder 2014: comparisons with other treatment guidelines

    Directory of Open Access Journals (Sweden)

    Jeong JH

    2015-06-01

    Full Text Available Jong-Hyun Jeong,1 Jeong Goo Lee,2,3 Moon-Doo Kim,4 Inki Sohn,5 Se-Hoon Shim,6 Hee Ryung Wang,1 Young Sup Woo,1 Duk-In Jon,7 Jeong Seok Seo,8 Young-Chul Shin,9 Kyung Joon Min,10 Bo-Hyun Yoon,11 Won-Myong Bahk1 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, 2Department of Psychiatry, Haeundae Paik Hospital, College of Medicine, Paik Institute for Clinical Research, Inje University, 3Department of Health Science and Technology, Graduate School of Inje University, Busan, 4Department of Psychiatry, Jeju National University Hospital, Jeju, 5Department of Psychiatry, Keyo Hospital, Keyo Medical Foundation, Uiwang, 6Department of Psychiatry, Soonchunhyang University Cheonan Hospital, College of Medicine, Soonchunhyang University, Cheonan, 7Department of Psychiatry, Sacred Heart Hospital, College of Medicine, Hallym University, Anyang, 8Department of Psychiatry, Konkuk University Chungju Hospital, School of Medicine, Konkuk University, Chungju, 9Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, 10Department of Psychiatry, Chung-Ang University Hospital, College of Medicine, Chung-Ang University, Seoul, 11Department of Psychiatry, Naju National Hospital, Naju, Korea Abstract: Our goal was to compare the recommendations of the Korean Medication Algorithm Project for Bipolar Disorder 2014 (KMAP-BP 2014 with other recently published guidelines for the treatment of bipolar disorder. We reviewed a total of four recently published global treatment guidelines and compared each treatment recommendation of the KMAP-BP 2014 with those in other guidelines. For the initial treatment of mania, there were no significant differences across treatment guidelines. All recommended mood stabilizer (MS or atypical antipsychotic (AAP monotherapy or the combination of an MS with an AAP as a first-line treatment strategy for mania. However, the KMAP-BP 2014 did not prefer monotherapy

  7. Influence of aripiprazole, risperidone, and amisulpride on sensory and sensorimotor gating in healthy 'low and high gating' humans and relation to psychometry.

    Science.gov (United States)

    Csomor, Philipp A; Preller, Katrin H; Geyer, Mark A; Studerus, Erich; Huber, Theodor; Vollenweider, Franz X

    2014-09-01

    Despite advances in the treatment of schizophrenia spectrum disorders with atypical antipsychotics (AAPs), there is still need for compounds with improved efficacy/side-effect ratios. Evidence from challenge studies suggests that the assessment of gating functions in humans and rodents with naturally low-gating levels might be a useful model to screen for novel compounds with antipsychotic properties. To further evaluate and extend this translational approach, three AAPs were examined. Compounds without antipsychotic properties served as negative control treatments. In a placebo-controlled, within-subject design, healthy males received either single doses of aripiprazole and risperidone (n=28), amisulpride and lorazepam (n=30), or modafinil and valproate (n=30), and placebo. Prepulse inhibiton (PPI) and P50 suppression were assessed. Clinically associated symptoms were evaluated using the SCL-90-R. Aripiprazole, risperidone, and amisulpride increased P50 suppression in low P50 gaters. Lorazepam, modafinil, and valproate did not influence P50 suppression in low gaters. Furthermore, low P50 gaters scored significantly higher on the SCL-90-R than high P50 gaters. Aripiprazole increased PPI in low PPI gaters, whereas modafinil and lorazepam attenuated PPI in both groups. Risperidone, amisulpride, and valproate did not influence PPI. P50 suppression in low gaters appears to be an antipsychotic-sensitive neurophysiologic marker. This conclusion is supported by the association of low P50 suppression and higher clinically associated scores. Furthermore, PPI might be sensitive for atypical mechanisms of antipsychotic medication. The translational model investigating differential effects of AAPs on gating in healthy subjects with naturally low gating can be beneficial for phase II/III development plans by providing additional information for critical decision making.

  8. Apodized-aperture pixel design to increase high-frequency DQE and reduce noise aliasing in x-ray detectors

    Science.gov (United States)

    Ismailova, Elina; Karim, Karim; Cunningham, Ian A.

    2015-03-01

    The detective quantum efficiency (DQE) of an x-ray detector, expressed as a function of spatial frequency, describes the ability to produce high-quality images relative to an ideal detector. While the DQE normally decreases substantially with increasing frequency, we describe an approach that can be used to improve the DQE response by increasing the DQE at high spatial frequencies. The approach makes use of an apodized-aperture pixel (AAP) design that requires use of a high-resolution x-ray converter such as selenium coupled to a sensor array with very small physical sensor elements, such as CMOS sensors. While sensors with elements of 10 - 25 μm are too small for most practical applications in medical radiography, we describe how larger image pixels of a practical size can be synthesized to provide a better DQE than simple binning or using physical pixels of the same size. A theoretical cascaded-systems analysis shows the DQE at the image sampling cut-off frequency can be improved by up to a factor of 2.5x. The AAP approach was validated experimentally using a CMOS/CsI-based detector having 0.05-mm sensor elements. Using AAP images with 0.2-mm pixels, the high-frequency DQE value was increased from 0.2 to 0.4 compared to simple 4x4 binning. It is concluded that ultra-high-resolution sensors can be used to optimize the high-frequency performance of x-ray detectors and make substantial improvements in image quality for visualization of small stuctures and fine image detail in comparison to current imaging systems.

  9. Restrictive Palivizumab Use Does Not Lead to Increased Morbidity and Mortality in Pediatric Hematopoietic Stem Cell Transplantation Patients.

    Science.gov (United States)

    Teusink-Cross, Ashley; Davies, Stella M; Danziger-Isakov, Lara; El-Bietar, Javier; Grimley, Michael S

    2016-10-01

    Respiratory syncytial virus (RSV) is a common cause of infection in immunocompromised patients and can lead to significant morbidity and mortality in pediatric hematopoietic stem cell transplantation (HSCT) patients and patients with a primary immune deficiency (PID). Palivizumab is a humanized monoclonal antibody that targets the F glycoprotein on the surface of the RSV virus, preventing RSV replication. Palivizumab was initially licensed for the prevention of RSV infections in children at high risk of severe disease. Since licensure, the American Academy of Pediatrics (AAP) has issued guidelines to help ensure appropriate use of palivizumab in pediatric patients. In the 2014 edition of the guidelines, the AAP recognizes that severe and fatal disease secondary to RSV can be seen in patients receiving chemotherapy or patients who are immunocompromised because of other conditions. However, they recognize that no large clinical trials exist to support the use of palivizumab, and efficacy and safety data in this population are limited. Despite this, the AAP recommends considering prophylaxis for children younger than 24 months who are profoundly immunocompromised during the RSV season. Because of the high cost of palivizumab, the uncertainty of its efficacy as prophylaxis in hospitalized pediatric HSCT and PID patients, and secondary to recent data from our center that suggested immunocompromised patients diagnosed with RSV did not have worse outcomes, we implemented very restrictive criteria for the use of palivizumab in the 2015 to 2016 RSV season in our pediatric HSCT population. Despite these strict criteria, there was no change in the number of patients developing RSV during this season compared with previous seasons, and there was no change in RSV course in those patients developing RSV compared with previous seasons. Restricted use also resulted in a significant dose and cost savings. Based on our experience, we recommend only administering prophylaxis

  10. Torradoviruses are transmitted in a semi-persistent and stylet-borne manner by three whitefly vectors.

    Science.gov (United States)

    Verbeek, Martin; van Bekkum, Petra J; Dullemans, Annette M; van der Vlugt, René A A

    2014-06-24

    Members of the genus Torradovirus (family Secoviridae, type species Tomato torrado virus, ToTV) are spherical plant viruses transmitted by the whitefly species Trialeurodes vaporariorum and Bemisia tabaci. Knowledge on the mode of vector transmission is lacking for torradoviruses. Here, the mode of transmission was determined for Tomato marchitez virus (ToMarV). A minimal acquisition access period (AAP) and inoculation access period (IAP) of approximately 2h each was required for its transmission by T. vaporariorum, while optimal transmission required an AAP and IAP of at least 16h and 8h, respectively. Whiteflies could retain the virus under non-feeding conditions for at least 8h without loss of transmission efficiency, but upon feeding on a non-host plant in between the AAP and IAP they retained the virus for no more than 8h. Similar conditions supported transmission of isolates of ToTV and Tomato chocolàte virus (ToChV) by T. vaporariorum and B. tabaci. Additionally, similar experiments revealed the banded-winged whitefly (Trialeurodes abutilonea) as a vector for all three virus species. The results are congruent with acquisition and retention periods for semi-persistent virus transmission. RT-PCR detection analysis of ToTV and ToMarV in the vector's body revealed their presence in the stylet, but not in the head where the pharynx of the foregut is located. The results altogether indicate a semi-persistent stylet-borne mode of vector transmission for torradoviruses. Additionally, this is the first group of spherical viruses transmitted by at least three different species of whiteflies.

  11. Comparison of polysaccharides of Haliotis discus hannai and Volutharpa ampullacea perryi by PMP-HPLC-MS(n) analysis upon acid hydrolysis.

    Science.gov (United States)

    Wang, Hongxu; Zhao, Jun; Li, Dongmei; Wen, Chengrong; Liu, Haiman; Song, Shuang; Zhu, Beiwei

    2015-10-13

    Haliotis discus hannai Ino (Haliotis) is a highly valued marine shellfish, and it is sometimes replaced by another cheaper Gastropoda mollusk, Volutharpa ampullacea perryi (Volutharpa). Polysaccharides from pleopods, viscera and gonads of these two gastropods were compared by analyzing the mono- and di-saccharides in their acid hydrolysates using high performance liquid chromatography-mass spectrometry (HPLC-MS(n)) after 1-phenyl-3-methyl-5-pyrazolone (PMP) derivatization. Disaccharide analysis revealed the distribution of uronic acid-containing polysaccharides (UACPs) in the biological samples. GlcA-(1 → 2)-Man, GlcA-(1 → 3)-GalN, and another disaccharide consisting of a hexuronic acid linked to a hexose were found in the hydrolysates, which indicated the existence of AGSP (abalone gonad sulfated polysaccharide) with the backbone composed of → 2)-α-Man(1 → 4)-β-GlcA(1 → repeating unit, AAP (abalone glycosaminoglycan-like polysaccharide) with the backbone of → 3)-GalNAc-(1 → 2)-GlcA-(1 → 3)-GalNAc-(1 → 4)-GlcA-(1 → repeating unit, and unidentified DS1P containing a hexuronic acid linked to a hexose unit, respectively. As shown by extracted ion chromatograms (XICs), AAP was the only UACP found in pleopods of the two gastropods; gonads and viscera of Haliotis contained DS1P and AGSP, while those of Volutharpa contained DS1P, AGSP as well as AAP. Monosaccharides in the acid hydrolysates were demonstrated in XICs by extracting their corresponding PMP derivative quasi-molecular ions one by one, and the results indicated the similar conclusion to the disaccharide analysis. Therefore, it could be concluded that polysaccharides from pleopods of the two gastropods are very similar, while those from their viscera and gonads differ greatly.

  12. The diagnosis and management of acute otitis media.

    Science.gov (United States)

    Lieberthal, Allan S; Carroll, Aaron E; Chonmaitree, Tasnee; Ganiats, Theodore G; Hoberman, Alejandro; Jackson, Mary Anne; Joffe, Mark D; Miller, Donald T; Rosenfeld, Richard M; Sevilla, Xavier D; Schwartz, Richard H; Thomas, Pauline A; Tunkel, David E

    2013-03-01

    This evidence-based clinical practice guideline is a revision of the 2004 acute otitis media (AOM) guideline from the American Academy of Pediatrics (AAP) and American Academy of Family Physicians. It provides recommendations to primary care clinicians for the management of children from 6 months through 12 years of age with uncomplicated AOM. In 2009, the AAP convened a committee composed of primary care physicians and experts in the fields of pediatrics, family practice, otolaryngology, epidemiology, infectious disease, emergency medicine, and guideline methodology. The subcommittee partnered with the Agency for Healthcare Research and Quality and the Southern California Evidence-Based Practice Center to develop a comprehensive review of the new literature related to AOM since the initial evidence report of 2000. The resulting evidence report and other sources of data were used to formulate the practice guideline recommendations. The focus of this practice guideline is the appropriate diagnosis and initial treatment of a child presenting with AOM. The guideline provides a specific, stringent definition of AOM. It addresses pain management, initial observation versus antibiotic treatment, appropriate choices of antibiotic agents, and preventive measures. It also addresses recurrent AOM, which was not included in the 2004 guideline. Decisions were made on the basis of a systematic grading of the quality of evidence and benefit-harm relationships. The practice guideline underwent comprehensive peer review before formal approval by the AAP. This clinical practice guideline is not intended as a sole source of guidance in the management of children with AOM. Rather, it is intended to assist primary care clinicians by providing a framework for clinical decision-making. It is not intended to replace clinical judgment or establish a protocol for all children with this condition. These recommendations may not provide the only appropriate approach to the management of this

  13. Promoting the well-being of children whose parents are gay or lesbian.

    Science.gov (United States)

    2013-04-01

    To promote optimal health and well-being of all children, the American Academy of Pediatrics (AAP) supports access for all children to (1) civil marriage rights for their parents and (2) willing and capable foster and adoptive parents, regardless of the parents' sexual orientation. The AAP has always been an advocate for, and has developed policies to support, the optimal physical, mental, and social health and well-being of all infants, children, adolescents, and young adults. In so doing, the AAP has supported families in all their diversity, because the family has always been the basic social unit in which children develop the supporting and nurturing relationships with adults that they need to thrive. Children may be born to, adopted by, or cared for temporarily by married couples, nonmarried couples, single parents, grandparents, or legal guardians, and any of these may be heterosexual, gay or lesbian, or of another orientation. Children need secure and enduring relationships with committed and nurturing adults to enhance their life experiences for optimal social-emotional and cognitive development. Scientific evidence affirms that children have similar developmental and emotional needs and receive similar parenting whether they are raised by parents of the same or different genders. If a child has 2 living and capable parents who choose to create a permanent bond by way of civil marriage, it is in the best interests of their child(ren) that legal and social institutions allow and support them to do so, irrespective of their sexual orientation. If 2 parents are not available to the child, adoption or foster parenting remain acceptable options to provide a loving home for a child and should be available without regard to the sexual orientation of the parent(s). PMID:23519941

  14. Effects of Matrix Composition on Detection Threshold Estimates for Methyl Anthranilate and 2-Aminoacetophenone

    Directory of Open Access Journals (Sweden)

    Demetra M. Perry

    2016-05-01

    Full Text Available Conceptually, a detection threshold represents the lowest concentration at which an individual or a group of individuals can reliably perceive a given stimulus, with a commonly used operational definition of 50% performance above chance. Estimated detection thresholds (DTs, however, are often reported in the literature with little attention given to the matrix in which the stimuli were evaluated. Here, we highlight the influence of matrix effects on DTs for two odor-active compounds commonly found in Vitis Labrusca wines. Differences in orthonasal DTs for methyl anthranilate (MA and 2-aminoacetophenone (2AAP in water, a model wine system, and wine were demonstrated using a within-subject design and forced choice (i.e., criterion free psychophysical methods. Six sample triads, each containing two blanks and one spiked sample, were presented to participants with the instructions to choose the “different” sample, and this was repeated in different matrices (water, model wine, and wine. The estimated DTs for both compounds were significantly lower in water versus the model wine system and wine. This finding recapitulates the strong need to carefully consider the nature of the delivery matrix when determining and comparing threshold estimates across studies. Additionally, data from prior reports have suggested DTs for MA and 2AAP may differ by two orders of magnitude in spite of their structural similarity. We failed to confirm this difference here: although 2AAP thresholds were somewhat lower than MA thresholds, differences were much smaller than what had been suggested previously. This, again, emphasizes the need to make comparisons within the same individuals, using appropriate methods with sufficient numbers of participants.

  15. Recent and Past Musical Activity Predicts Cognitive Aging Variability: Direct Comparison with Leisure Activities

    Directory of Open Access Journals (Sweden)

    Brenda eHanna-Pladdy

    2012-07-01

    Full Text Available Studies evaluating the impact of modifiable lifestyle factors on cognition offer potential insights into sources of cognitive aging variability. Recently, we reported an association between extent of musical instrumental practice throughout the life span (greater than 10 years on preserved cognitive functioning in advanced age . These findings raise the question of whether there are training-induced brain changes in musicians that can transfer to nonmusical cognitive abilities to allow for compensation of age-related cognitive declines. However, because of the relationship between engagement in lifestyle activities and preserved cognition, it remains unclear whether these findings are specifically driven by musical training or the types of individuals likely to engage in greater activities in general. The current study examined the type of leisure activity (musical versus other as well as the timing of engagement (age of acquisition, past versus recent in predictive models of successful cognitive aging. Seventy age and education matched older musicians (> 10 years and nonmusicians (ages 59-80 were evaluated on neuropsychological tests and life-style activities (AAP. Partition analyses were conducted on significant cognitive measures to explain performance variance in musicians. Musicians scored higher on tests of phonemic fluency, verbal immediate recall, judgment of line orientation (JLO, and Letter Number Sequencing (LNS, but not the AAP. The first partition analysis revealed education best predicted JLO in musicians, followed by recent musical engagement which offset low education. In the second partition analysis, early age of musical acquisition (< 9 years predicted enhanced LNS in musicians, while analyses for AAP, verbal recall and fluency were not predictive. Recent and past musical activity, but not leisure activity, predicted variability across verbal and visuospatial domains in aging. Early musical acquisition predicted auditory

  16. 国际风云

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    韩投资建IT中心 欲成全球RFID巨头;80%的公司缺少RFID人才;多家医疗机构使用RFID技术进行资产管理;亚洲项目实施工作组(AAP)正式启动;EPCglobal成立实用标签性能工作组;思科与欧洲RFID中心共推基于IP的RFID设备。

  17. The Aminopeptidase Inhibitor CHR-2863 Is an Orally Bioavailable Inhibitor of Murine Malaria

    OpenAIRE

    Skinner-Adams, Tina S.; Peatey, Christopher L.; Anderson, Karen; Trenholme, Katharine R.; Krige, David; Christopher L. Brown; Stack, Colin; Nsangou, Desire M. M.; Mathews, Rency T.; Thivierge, Karine; Dalton, John P; GARDINER, DONALD L.

    2012-01-01

    Malaria remains a significant risk in many areas of the world, with resistance to the current antimalarial pharmacopeia an ever-increasing problem. The M1 alanine aminopeptidase (PfM1AAP) and M17 leucine aminopeptidase (PfM17LAP) are believed to play a role in the terminal stages of digestion of host hemoglobin and thereby generate a pool of free amino acids that are essential for parasite growth and development. Here, we show that an orally bioavailable aminopeptidase inhibitor, CHR-2863, is...

  18. Safety and Efficacy Assessment of Flow Redistribution by Occlusion of Intrahepatic Vessels Prior to Radioembolization in the Treatment of Liver Tumors

    International Nuclear Information System (INIS)

    We evaluated the feasibility, safety, and efficacy of radioembolization (administered from one or two vascular points) after the redistribution of arterial blood flow in the liver in patients with hepatic neoplasms and arterial anatomic peculiarities (AAP). Twenty-four patients with liver neoplasms and AAP (graded according to Michel's classification) were included in the study. During pretreatment angiographic planning, all extrahepatic vessels that could feed the tumor were embolized and the intrahepatic vessels occluded in order to redistribute blood flow. The distribution of microspheres was initially assessed by using technetium-99m-labeled macroaggregated albumin (99mTc-MAA) from one of two vascular points before the administration of yttrium-90 (90Y)-radiolabeled resin microspheres. Perfusion of lesions situated in the redistributed segments (L-RS) and nonredistributed segments (L-NRS) were compared by assessing the distribution of 99mTc-MAA by SPECT/CT. Perfusion was graded as normal, reduced, or absent. 90Y resin microspheres were then injected from the same arterial sites as 99mTc-MAA and the tumor response recorded 3 months later. The tumor response in L-RS was compared with that in L-NRS and graded as better, similar, or worse. Among 11 patients with type I AAP in whom mainly vessels in segments I-III or IV were occluded, perfusion of L-RS was graded as similar (n = 7) or reduced (n = 4). Among the remaining 13 patients with AAP types III (n = 3), V (n = 4), VIII (n = 3), and others (n = 3) in which aberrant arteries were occluded, perfusion of L-RS was graded as similar (n = 9), reduced (n = 3), or absent (n = 1). Overall, 99mTc-MAA was present in the L-RS of 95.8% patients and the distribution of 99mTc-MAA in L-RS and L-NRS were graded as similar in 66.6% of patients. Compared with lesions in the L-NRS, tumor response in L-RS was similar in 23 cases and worse in 1 case. No complications were recorded after the administration of 90Y resin microspheres

  19. Study on preparation and antigenicity activity of glycosylation products derived from whey protein and auricularia auricula polysaccharide%黑木耳多糖-乳清蛋白复合物的制备及其抗原性的研究

    Institute of Scientific and Technical Information of China (English)

    齐晓彦; 李春; 张微; 刘宁

    2012-01-01

    Protein and polysaccharide covalent complex through Maillard could form protein-polysaccharide conjugations which showed excellent properties.And the conjugates of whey protein and auricularia auricula polysaccharides(AAP)were studied by means of the dry-heating glycosylated reaction.It was shown that after the whey protein and Auricularia auricula polysaccharides(AAP)of different mass ratio reacting for different time,the antigenicity of β-LG and α-LA were estimated by indirect competition ELISA.The results indicated that the glycolsylation of whey protein could reduce the antigenicity of β-LG and α-LA.The optimum reaction condition were WPI and AAP(1:1 weight ratio)for 24 hours could reduce the antigenicity of whey protein effectively,The antigenicity of bovine milk β-LG and α-LA was reduced by conjugation with AAP,about 75.7% and 25% respectively.%蛋白质和多糖在控制条件下通过美拉德反应会发生一定程度的共价复合,能显示更优越的性能。采用黑木耳多糖作为糖基供体,用糖基化的手段与牛乳中乳清蛋白结合形成木耳多糖-乳清蛋白复合物,并在现有的条件下探索不同质量比与不同反应时间对糖基化进程的影响,采用间接竞争ELISA法测定复合物中β-乳球蛋白和α-乳白蛋白抗原性的影响。结果表明,乳清蛋白与黑木耳多糖质量比为1:1,反应时间为24h,是糖基化反应最佳条件并且能有效减低乳清蛋白抗原性,其中β-乳球蛋白抗原性降低率为75.7%,α-乳白蛋白抗原性降低率为25%。

  20. Technology assessment of RDX production

    Energy Technology Data Exchange (ETDEWEB)

    Coburn, M.D. [New Mexico Inst. of Mining and Technology, Socorro, NM (United States)

    1995-04-01

    The known processes for producing RDX were assessed with the goal of identifying the process that would generate the least waste and pollution. It was concluded that the Bachman process employed at Holston AAP is the most economical process for producing RDX and that it probably produces less waste than any other process. It was generally agreed that the entire Holston operation is a very clean one that complies with all federal and state emission standards. In addition, a number of opportunities in which Holston could reduce their wastes were identified. Preliminary assessments of waste and pollution profiles for alternate materials, with emphasis on dual-use materials, were performed.

  1. DOI简介

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>DOI(Digital Object Identifier),即文献数字对象识别号,为美国出版商协会(The Association of American Publishers,AAP)于1994年建立;1997年成为数字资源命名的一项标准。DOI能让学术文章永久寻址,实现文献永续存在。《厦门大学法律评论》从2013年起,通过台湾元照出版公司提供的平台,正式加入DOI

  2. NCBI nr-aa BLAST: CBRC-TNIG-12-0002 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 2e-95 46% ... ...CBRC-TNIG-12-0002 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  3. NCBI nr-aa BLAST: CBRC-MMUR-01-1599 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 89% ... ...CBRC-MMUR-01-1599 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  4. NCBI nr-aa BLAST: CBRC-VPAC-01-1477 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 84% ... ...CBRC-VPAC-01-1477 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  5. NCBI nr-aa BLAST: CBRC-OLAT-09-0012 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 8e-93 50% ... ...CBRC-OLAT-09-0012 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  6. NCBI nr-aa BLAST: CBRC-TBEL-01-2493 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 1e-116 90% ... ...CBRC-TBEL-01-2493 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  7. NCBI nr-aa BLAST: CBRC-CJAC-01-0928 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 91% ... ...CBRC-CJAC-01-0928 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  8. NCBI nr-aa BLAST: CBRC-TTRU-01-0295 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 86% ... ...CBRC-TTRU-01-0295 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  9. NCBI nr-aa BLAST: CBRC-DNOV-01-2809 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 85% ... ...CBRC-DNOV-01-2809 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  10. NCBI nr-aa BLAST: CBRC-CFAM-03-0005 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 83% ... ...CBRC-CFAM-03-0005 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  11. NCBI nr-aa BLAST: CBRC-PTRO-06-0019 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 99% ... ...CBRC-PTRO-06-0019 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  12. NCBI nr-aa BLAST: CBRC-FRUB-02-0029 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 1e-93 52% ... ...CBRC-FRUB-02-0029 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  13. NCBI nr-aa BLAST: CBRC-HSAP-05-0018 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 99% ... ...CBRC-HSAP-05-0018 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  14. NCBI nr-aa BLAST: CBRC-STRI-01-2861 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 88% ... ...CBRC-STRI-01-2861 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  15. Uus tootedisain = New product design / Monika Järg

    Index Scriptorium Estoniae

    Järg, Monika, 1975-

    2012-01-01

    Tutvustatakse: mööblisari Smart (Tarmo Luisk, 2011) ja Slice (Tarmo Luisk, 2008), rattahoidja Typo (Tarmo Luisk) ja Tulip Fan Fan (Margus Triibmann, 2011), iste Seat (Monika Järg), mööbliseeria Maast: tool CHO1 ja laud TBO1 (Tõnis Kalve, Aap Piho, 2011), padjad KO! (Kärt Ojavee, 2011), vaibakollektsioon Unlimited (Kaidi Ploomipuu, Monika Järg, 2011), vann Aquator CLAUDE 170 (2011), büroomööbli seeria Metod (Iseasi, 2012), rippvalgusti Aero (Tõnis Vellama, 2011), tool Must ja nagi Z (Toivo Raidmets, 2008-2012)

  16. Proceso de sensibilización y empoderamiento local frente al uso sostenible del suelo en la microcuenca El Limón, cuencas altas Sabana Yegua, República Dominicana

    OpenAIRE

    Maldané Cuello Espinosa

    2011-01-01

    Este artículo trata el desarrollo de un proceso de sensibilización y empoderamiento por parte de los productores y productoras agrícolas de la microcuenca El Limón, dentro del complejo de cuencas que alimentan a la presa Sabana Yegua, en República Dominicana. La metodología implementada en el proceso se basa en un enfoque participativo local, que a su vez está basado en el modelo de Acción Ambiental Positiva (AAP), el cual incluye los elementos de habilidades y procedimientos, conceptos, empo...

  17. Gene : CBRC-MMUS-11-0114 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-11-0114 11 A Odorant/olfactory and gustatory receptors OR3A1_HUMAN 1e-155... 84% ref|NP_666918.1| olfactory receptor 410 [Mus musculus] gb|AAL61051.1| olfactory receptor MOR255-5 [Mus musculus...] gb|AAP70932.1| olfactory receptor Olfr410 [Mus musculus] emb|CAI24527.1| olfactory receptor 410 [Mus musculus...] gb|EDL12768.1| mCG52814 [Mus musculus] 1e-180 100% gnl|UG|Mm#S9745013 Mus musculus

  18. Gene : CBRC-MMUS-19-0084 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-19-0084 19 A Odorant/olfactory and gustatory receptors OR9I1_HUMAN 1e-148... 82% ref|NP_667008.1| olfactory receptor 1502 [Mus musculus] gb|AAL60960.1| olfactory receptor MOR211-1 [Mus musculus...] gb|AAP71851.1| olfactory receptor Olfr1502 [Mus musculus] gb|AAI06811.1| Olfactory receptor 1502 [Mus musculus...] gb|EDL41523.1| mCG55155 [Mus musculus] 1e-180 100% gnl|UG|Mm#S27582255 Mus musculus

  19. Gene : CBRC-MMUS-11-0101 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-11-0101 11 A Odorant/olfactory and gustatory receptors OR3A4_HUMAN 1e-139... 83% gb|AAP70925.1| olfactory receptor Olfr399 [Mus musculus] emb|CAI24631.1| olfactory receptor 399 [Mus musculus...] gb|AAI20847.1| Olfactory receptor 399 [Mus musculus] gb|AAI20821.1| Olfactory receptor 399 [Mus musculus...] gb|EDL12753.1| olfactory receptor 399 [Mus musculus] 1e-177 100% gnl|UG|Mm#S34285683 Mus musculus

  20. Gene : CBRC-MMUS-11-0110 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-11-0110 pseudo Novel 11 A Odorant/olfactory and gustatory receptors OR1A1..._PANTR 2e-69 53% gb|AAP70929.1| olfactory receptor Olfr43 [Mus musculus] emb|CAI24518.1| olfactory receptor 43 [Mus musculus...] gb|AAI25465.1| Olfactory receptor 43 [Mus musculus] gb|AAI25469.1| Olfactory receptor 43 [Mus musculus...] gb|EDL12760.1| mCG1036248 [Mus musculus] 1e-81 61% gnl|UG|Mm#S35209285 Mus musculus

  1. Gene : CBRC-MMUS-07-0414 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-07-0414 7 A Odorant/olfactory and gustatory receptors O51A7_HUMAN 1e-133 ...76% ref|NP_667321.1| olfactory receptor 570 [Mus musculus] gb|AAL60639.1| olfactory receptor MOR8-3 [Mus musculus...] gb|AAP71060.1| olfactory receptor Olfr570 [Mus musculus] gb|AAI16967.1| Olfactory receptor 570 [Mus musculus...] gb|EDL16635.1| olfactory receptor 570 [Mus musculus] 1e-175 100% gnl|UG|Mm#S33850657 Mus mus

  2. Gene : CBRC-MMUS-10-0061 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-10-0061 10 A Odorant/olfactory and gustatory receptors OR7AH_HUMAN 1e-121... 71% ref|NP_667251.1| olfactory receptor 1351 [Mus musculus] gb|AAL60711.1| olfactory receptor MOR139-4 [Mus musculus...] gb|AAP71735.1| olfactory receptor Olfr1351 [Mus musculus] gb|AAI04113.1| Olfactory receptor 1351 [Mus musculus...] gb|EDL31709.1| mCG52449 [Mus musculus] 1e-180 100% gnl|UG|Mm#S26988969 Mus musculus

  3. Gene : CBRC-MMUS-07-0515 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-07-0515 7 A Odorant/olfactory and gustatory receptors O52N5_HUMAN 1e-159 ...88% ref|NP_667254.1| olfactory receptor 669 [Mus musculus] gb|AAL60708.1| olfactory receptor MOR34-6 [Mus musculus...] gb|AAP71140.1| olfactory receptor Olfr669 [Mus musculus] gb|AAI04301.1| Olfactory receptor 669 [Mus musculus...] gb|EDL16746.1| olfactory receptor 669 [Mus musculus] 0.0 100% gnl|UG|Mm#S26988998 Mus musculus

  4. Gene : CBRC-MMUS-02-0242 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0242 2 A Odorant/olfactory and gustatory receptors OR4P4_HUMAN 1e-117 ...66% ref|NP_667034.1| olfactory receptor 1184 [Mus musculus] gb|AAL60933.1| olfactory receptor MOR225-3 [Mus musculus...] gb|AAP71595.1| olfactory receptor Olfr1184 [Mus musculus] emb|CAM17508.1| olfactory receptor 1184 [Mus musculus...L27434.1| olfactory receptor 1184 [Mus musculus] 0.0 100% gnl|UG|Mm#S9745121 Mus musculus olfactory receptor

  5. Gene : CBRC-MMUS-09-0098 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-09-0098 9 A Odorant/olfactory and gustatory receptors OL147_MOUSE 1e-126 ...72% ref|NP_667015.1| olfactory receptor 905 [Mus musculus] gb|AAL60953.1| olfactory receptor MOR167-1 [Mus musculus...] gb|AAP71380.1| olfactory receptor Olfr905 [Mus musculus] gb|EDL25460.1| mCG53365 [Mus musculus] gb|...AAI50477.1| Olfactory receptor 905 [Mus musculus] 1e-173 98% gnl|UG|Mm#S39545474 Mus musculus

  6. PDF for Healthcare and Child Health Data Forms.

    Science.gov (United States)

    Zuckerman, Alan E; Schneider, Joseph H; Miller, Ken

    2008-01-01

    PDF-H is a new best practices standard that uses XFA forms and embedded JavaScript to combine PDF forms with XML data. Preliminary experience with AAP child health forms shows that the combination of PDF with XML is a more effective method to visualize familiar data on paper and the web than the traditional use of XML and XSLT. Both PDF-H and HL7 Clinical Document Architecture can co-exist using the same data for different display formats. PMID:18999257

  7. NCBI nr-aa BLAST: CBRC-GGOR-01-1322 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GGOR-01-1322 ref|NP_060106.2| transient receptor potential cation channel, sub...annel subfamily M member 4; AltName: Full=Long transient receptor potential channel 4; Short=LTrpC4; Short=h...cation channel 1 gb|AAM18083.1|AF497623_1 cation channel TRPM4B [Homo sapiens] gb|AAP44474.1| transient rece...ptor potential cation channel subfamily M member 4 splice variant B [Homo sapiens] emb|CAE05941.1| transient

  8. Intramolecular and intermolecular hydrogen-bonding effects on photophysical properties of 2'-aminoacetophenone and its derivatives in solution.

    Science.gov (United States)

    Shimada, Hirofumi; Nakamura, Akihito; Yoshihara, Toshitada; Tobita, Seiji

    2005-04-01

    Effects of intra- and intermolecular hydrogen-bonds on the photophysical properties of 2'-aminoacetophenone derivatives (X-C6H4-COCH3) having a substituted amino group (X) with different hydrogen-bonding ability to the carbonyl oxygen (X: NH2(AAP), NHCH3(MAAP), N(CH3)2(DMAAP), NHCOCH3(AAAP), NHCOCF3(TFAAP)) are investigated by means of steady-state and time-resolved fluorescence spectroscopy and time-resolved thermal lensing. Based on the photophysical parameters obtained in aprotic solvents with different polarity and protic solvents with different hydrogen-bonding ability, the characteristic photophysical behavior of the 2'-aminoacetophenone derivatives is discussed in terms of hydrogen-bonding and n,pi*-pi,pi* vibronic coupling. The dominant deactivation process of AAP and MAAP in nonpolar aprotic solvents is the extremely fast internal conversion (k(ic)= 1.0 x 10(11) s(-1) for AAP and 3.9 x 10(10) s(-1) for MAAP in n-hexane). The internal conversion rates of both compounds decrease markedly with increasing solvent polarity, suggesting that vibronic interactions between close-lying S1(pi,pi*) and S2(n,pi*) states lead to the large increase in the non-radiative decay rate of the lowest excited singlet state. It is also suggested that for MAAP, which has a stronger hydrogen-bond as compared to AAP, an intramolecular hydrogen-bonding induced deactivation is involved in the dissipation of the S1 state. For DMAAP, which cannot possess an intramolecular hydrogen-bond, the primary relaxation mechanism of the S1 state in nonpolar aprotic solvents is the intersystem crossing to the triplet state, whereas in protic solvents very efficient internal conversion due to intermolecular hydrogen-bonding is induced. In contrast, the fluorescence spectra of AAAP and TFAAP, which have an amino group with a much stronger hydrogen-bonding ability, give strongly Stokes-shifted fluorescence, indicating that these compounds undergo excited-state intramolecular proton transfer reaction

  9. Uus kuum Eesti disain / Silvia Pärmann, Maris Takk

    Index Scriptorium Estoniae

    Pärmann, Silvia

    2015-01-01

    Karl Tauli disainitud taburet "Ämblu", Aap Piho puidust ümmargune laud, Marit Ilisoni tekkmantlid kollektsioonist "Longing for Sleep/Magada tahaks", Narma vaibakollektsioon "OPEN 2015/16" (disainerid Monika Järg, Kaidi Ploomipuu), Annike Laigo vaibakollektsioon "XX", Kairi Katmanni vaip "Storytellers", Valhalla Factory kollektsiooni "Daydreamers" ripptool, Raili Keivi betoonist ja portselanist nõudekollektsioon, Tarmo Luisu valgusti "Kassett", Stella Soomlaisi käekotid, Karin Kallase ja Erik Pasti (Stuudio Nahk) disainitud jalatsid, käekotid ja ehted, Kuula + Jylhä jalatsikollektsioon, Mokoko (disainer Mari Maripuu) nahast aksessuaarid

  10. NCBI nr-aa BLAST: CBRC-ETEL-01-0465 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0465 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  11. NCBI nr-aa BLAST: CBRC-GACU-07-0011 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GACU-07-0011 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  12. NCBI nr-aa BLAST: CBRC-XTRO-01-2768 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-2768 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  13. NCBI nr-aa BLAST: CBRC-OCUN-01-1620 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OCUN-01-1620 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  14. NCBI nr-aa BLAST: CBRC-ETEL-01-1373 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-1373 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  15. NCBI nr-aa BLAST: CBRC-ACAR-01-0438 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ACAR-01-0438 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  16. NCBI nr-aa BLAST: CBRC-HSAP-04-0027 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-HSAP-04-0027 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  17. NCBI nr-aa BLAST: CBRC-DRER-07-0072 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DRER-07-0072 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  18. NCBI nr-aa BLAST: CBRC-CBRE-01-0701 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CBRE-01-0701 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  19. NCBI nr-aa BLAST: CBRC-FCAT-01-1015 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FCAT-01-1015 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  20. NCBI nr-aa BLAST: CBRC-MMUS-05-0020 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-05-0020 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  1. NCBI nr-aa BLAST: CBRC-PTRO-05-0018 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PTRO-05-0018 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  2. NCBI nr-aa BLAST: CBRC-PABE-05-0014 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PABE-05-0014 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  3. NCBI nr-aa BLAST: CBRC-CFAM-03-0027 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CFAM-03-0027 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  4. NCBI nr-aa BLAST: CBRC-OLAT-18-0070 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OLAT-18-0070 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  5. NCBI nr-aa BLAST: CBRC-RMAC-05-0007 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RMAC-05-0007 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  6. NCBI nr-aa BLAST: CBRC-ETEL-01-0940 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0940 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  7. NCBI nr-aa BLAST: CBRC-CJAC-01-1653 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CJAC-01-1653 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  8. NCBI nr-aa BLAST: CBRC-TGUT-06-0015 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TGUT-06-0015 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  9. NCBI nr-aa BLAST: CBRC-GGAL-04-0036 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GGAL-04-0036 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  10. NCBI nr-aa BLAST: CBRC-CPOR-01-1990 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CPOR-01-1990 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  11. NCBI nr-aa BLAST: CBRC-BTAU-01-2281 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-2281 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  12. NCBI nr-aa BLAST: CBRC-CBRE-01-1028 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CBRE-01-1028 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  13. NCBI nr-aa BLAST: CBRC-LAFR-01-0624 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0624 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  14. NCBI nr-aa BLAST: CBRC-GACU-16-0038 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GACU-16-0038 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  15. NCBI nr-aa BLAST: CBRC-CBRE-01-1053 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CBRE-01-1053 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  16. NCBI nr-aa BLAST: CBRC-DRER-01-0042 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DRER-01-0042 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  17. Biofilm characteristics of Staphylococcus epidermidis isolates associated with device-related meningitis.

    LENUS (Irish Health Repository)

    Stevens, Niall T

    2009-07-01

    Staphylococcus epidermidis biofilm causes device-related meningitis in neurosurgical patients. This study assessed the contribution of polysaccharide and protein to the development of a strong biofilm-positive phenotype in four S. epidermidis isolates associated with probable device-related meningitis, under varying environmental conditions. RT-PCR analysis of the intercellular adhesion operon (icaADBC) and assessment of polysaccharide intercellular adhesin (PIA) production indicated a correlation between increased icaA transcription and PIA production in ica(+) isolates grown in medium with 4 % ethanol and 4 % NaCl. Treatment of biofilm with sodium metaperiodate caused dispersion of adhered cells (P <0.0001), indicating involvement of PIA. Transcriptional levels of protein factors revealed that atlE transcription levels were similar in all isolates, whilst aap levels were variable, with induction being seen in two isolates following growth in the presence of alcohol or salt. Transcription of agr did not influence protein expression and RNAIII transcription varied among the strains. Although aap transcription was induced, the treatment of biofilm with proteinase K did not always disperse the biofilm. Our data suggest that, among the three ica(+) S. epidermidis isolates clinically associated with meningitis that were studied, PIA contributed to the strong biofilm-positive phenotype, whereas protein factors appeared to have a secondary role.

  18. Adult Attachment, Social Adjustment, and Well-Being in Drug-Addicted Inpatients.

    Science.gov (United States)

    Delvecchio, Elisa; Di Riso, Daniela; Lis, Adriana; Salcuni, Silvia

    2016-04-01

    In recent years, attachment studies have gathered overwhelming evidence for a relation between insecure attachment and drug addiction. The existing literature predominantly addresses attachment styles and little attention is given to attachment-pattern-oriented studies. The current study explored how attachment, social adjustment, and well-being interact in 40 (28 men, 12 women; ages 20-52 years, M = 32.3, SD = 9.4) inpatients with drug addiction. The Adult Attachment Projective Picture System (AAP), the Social Adjustment Scale-Self-report (SAS-SR), and the General Health Questionnaire-28 (GHQ-28) were administered. Descriptive statistics were computed as well as differences between patterns of attachment in all variables were measured. None of the inpatients showed a secure attachment pattern: 7 scored as dismissing (18%), 5 preoccupied (12%) and 28 unresolved (70%). AAP stories were mainly connected with themes of danger, lack of protection, and helplessness. Inpatients classified as unresolved reported significantly higher maladjustment on the SAS-SR and GHQ-28 than those with resolved attachment patterns. Implications for clinicians and researchers are presented.

  19. 美国儿科学会胎儿和新生儿委员会《新生儿低血糖症筛查和后续管理指南(2011年版)》解读%Interpretation of Practical Guide and Algorithm for the Screening and Subsequent Management of Neonatal Hypoglycemia formulated by the American Academy of Pediatrics Committee on Fetus and Newborn

    Institute of Scientific and Technical Information of China (English)

    陈昌辉; 李茂军; 吴青; 石伟

    2011-01-01

    美国儿科学会新生儿专业委员会制定了2011年版新生儿低血糖症筛查和后续管理指南(简称指南).除高危新生儿外,指南不推荐常规监测血糖.2011年3月指南由Adamkin DH及其同事在《Pediatrics》发表,内容包括哪些新生儿需要筛查、何时筛查、实验室资料、临床体征和管理.%The American Academy of Pediatrics (AAP) Committee on Fetus and Newborn has waged an opinion on neonatal hypoglycemia and produced a Practical Guide and Algorithm for the Screening and Subsequent Management of Neonatal Hypoglycemia (hereinafter, "guideline") . The guidelines recommend against routine glucose monitoring except for high-risk infants. The AAP guideline, reported in the March issue of Pediatrics by David H. Adamkin, MD, and colleagues, includes which infants to screen, when to screen, laboratory data, clinical signs, and management

  20. Inactivation of yeast alcohol dehydrogenase by alkylperoxyl radicals. Characteristics and influence of nicotinamide-adenine dinucleotides.

    Science.gov (United States)

    Videla, L A; Salim-Hanna, M; Lissi, E A

    1992-10-01

    The study of the interaction of alkylperoxyl radicals generated by the aerobic thermolysis of 2,2'-azobis(2-amidinopropane) (AAP) with yeast alcohol dehydrogenase (YADH) revealed a high reactivity of the enzyme, with an average of about 20 radicals per added YADH tetramer being needed to elicit its total inactivation. NAD+ enhanced YADH inactivation at NAD+/YADH molar ratios from 0.25 to 1, decreasing the rate of the process when added in excess to the enzyme concentration. At NADH/YADH molar ratios greater than 1, NADH exhibited a protective effect characterized by a poorly defined induction time and lower inactivation rates, which progressively increased during the reaction period. These changes occurred concomitantly with the oxidation of NADH into NAD+, which might counteract the protective effect of NADH. Under similar conditions, NADP+ did not modify AAP-induced YADH inactivation, while NADPH exhibited a modest protection at NADPH/YADH molar ratios greater than 1. It is concluded that YADH inactivation by alkylperoxyl radicals is strongly dependent on the redox state of the NADH-NAD+ couple, as the rates of the process at different time intervals inversely correlate with the respective NADH/NAD+ ratios.

  1. Enhanced stability of multilayer graphene-supported catalysts for polymer electrolyte membrane fuel cell cathodes

    Science.gov (United States)

    Marinkas, A.; Hempelmann, R.; Heinzel, A.; Peinecke, V.; Radev, I.; Natter, H.

    2015-11-01

    One of the biggest challenges in the field of polymer electrolyte membrane fuel cells (PEMFC) is to enhance the lifetime and the long-term stability of PEMFC electrodes, especially of cathodes, furthermore, to reduce their platinum loading, which could lead to a cost reduction for efficient PEMFCs. These demands could be achieved with a new catalyst support architecture consisting of a composite of carbon structures with significant different morphologies. A highly porous cathode catalyst support layer is prepared by addition of various carbon types (carbon black particles, multi-walled carbon nanotubes (MWCNT)) to multilayer graphene (MLG). The reported optimized cathodes shows extremely high durability and similar performance to commercial standard cathodes but with 89% lower Pt loading. The accelerated aging protocol (AAP) on the membrane electrode assemblies (MEA) shows that the presence of MLG increases drastically the durability and the Pt-extended electrochemical surface area (ECSA). In fact, after the AAP slightly enhanced performance can be observed for the MLG-containing cathodes instead of a performance loss, which is typical for the commercial carbon-based cathodes. Furthermore, the presence of MLG drastically decreases the ECSA loss rate. The MLG-containing cathodes show up to 6.8 times higher mass-normalized Pt-extended ECSA compared to the commercial standard systems.

  2. Design and characterization of an acid-activated antimicrobial peptide.

    Science.gov (United States)

    Li, Lina; He, Jian; Eckert, Randal; Yarbrough, Daniel; Lux, Renate; Anderson, Maxwell; Shi, Wenyuan

    2010-01-01

    Dental caries is a microbial biofilm infection in which the metabolic activities of plaque bacteria result in a dramatic pH decrease and shift the demineralization/remineralization equilibrium on the tooth surface towards demineralization. In addition to causing a net loss in tooth minerals, creation of an acidic environment favors growth of acid-enduring and acid-generating species, which causes further reduction in the plaque pH. In this study, we developed a prototype antimicrobial peptide capable of achieving high activity exclusively at low environmental pH to target bacterial species like Streptococcus mutans that produce acid and thrive under the low pH conditions detrimental for tooth integrity. The features of clavanin A, a naturally occurring peptide rich in histidine and phenylalanine residues with pH-dependent antimicrobial activity, served as a design basis for these prototype 'acid-activated peptides' (AAPs). Employing the major cariogenic species S. mutans as a model system, the two AAPs characterized in this study exhibited a striking pH-dependent antimicrobial activity, which correlated well with the calculated charge distribution. This type of peptide represents a potential new way to combat dental caries. PMID:19878192

  3. Attachment disorganization in different clinical groups: What underpins unresolved attachment?

    Directory of Open Access Journals (Sweden)

    Juen Florian

    2013-01-01

    Full Text Available This paper summarizes findings and clinical implications of research on attachment disorganization in diverse clinical groups. Disorganized/unresolved attachment is overrepresented in these groups compared to healthy control participants, but disorder specific characteristics of this attachment pattern are still poorly understood. The focus of this study was to explore defensive processes in participants whose narratives were classified as disorganized/unresolved using the Adult Attachment Projective Picture System (AAP. Besides the predominance of disorganized attachment, clinical participants demonstrated more “segregated system material” especially in stories representing aloneness and more “Personal Experience material” compared to healthy individuals. Within the disorganized/ unresolved clinical individuals, BPD and PTSD patients showed the highest proportion of attachment disorganization and were less able to use other attachment-related defenses to maintain organized. Furthermore, PTSD patients were emotionally overwhelmed by the projective attachment scenes compared to the other clinical groups as indexed by an incapacity to complete sections of the AAP. BPD and addicted patients were characterized by a high degree of self-other boundary confusion. Depressive and schizophrenic patients showed a high overall defensive intensity to remain organized.

  4. [Percutaneous exclusion of traumatic abdominal aortic pseudoaneurysm from a brachial approach].

    Science.gov (United States)

    Gamboa, Ricardo; Ríos-Méndez, Raúl E; Solernó, Raúl; Giachello, Federico; Videla-Lynch, Ángeles; Sarmiento, Ricardo A

    2012-01-01

    Abdominal aortic pseudoaneurysm (AAP) is a rare lesion, although traumatic aortic injury is described as one of the main causes; both the rupture as the surgical treatment of the defect has high morbidity and mortality. Therefore, endovascular treatment either by chemical embolization or exclusion of defect with devices has emerged as an alternative treatment. However, there are risks such as occlusion of visceral vessels near the neck of the defect, embolization material or aortic rupture. Therefore, the choice of material and method of approach should be planned carefully in each case. We report a patient who ten years after abdominal wound firearm was diagnosed with AAP 17 x 13 cm, with short neck originated close to the ostium of the celiac trunk at an acute angle with the aortic axis. We perform the exclusion of the defect with a device designed for closing atrial septal defect from the left brachial access due to the angulation of the neck defect. There were no complications. At 72 hours was granted discharge. A month later, CT scan control showed the false aneurysm of equal size and no residual flow. The monitoring to date is five months and the patient remained asymptomatic.

  5. Investigation of nutrient sensing in the yeast Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Eckert-Boulet, Nadine

    2006-01-01

    -citrulline kan ikke optages af disse stammer, da de mangler GAP1 (General Amino acid Permease). Det blev bekræftet, at AAP generne TAT1, BAP2, BAP3 og PTR2 er under kontrol af aminosyre induktionsvejen, mens AGP2 blev identificeret som et nyt gen under kontrol af denne mekanisme. Den globale...... for at aminosyre induktion kan finde sted. Hel-genom transkriptionsanalyser af en vildtype stamme og en grr1 stamme med og uden L-citrullin blev udført. Dataanalyse viste at aminosyre induktion af AAP generne AGP1, BAP2, BAP3, DIP5, TAT1, og GNP1 er helt afhængig af tilstedeværelsen af GRR1. Sammenligningen af de....... RTS1 blev slået ud, og dette medførte konstitutiv aktivering af AGP1 og BAP2 promotorer. Dette var afhængigt af SSY1, PTR3, SSY5, GRR1 eller STP1, STP2 og deres homolog STP3. Den forøgede transkription fra AGP1 og BAP2 promotorer i rts1 celler ser ud til at skyldes forøget processering af Stp1p. Med...

  6. The lysine biosynthetic enzyme Lys4 influences iron metabolism, mitochondrial function and virulence in Cryptococcus neoformans.

    Science.gov (United States)

    Do, Eunsoo; Park, Minji; Hu, Guanggan; Caza, Mélissa; Kronstad, James W; Jung, Won Hee

    2016-09-01

    The lysine biosynthesis pathway via α-aminoadipate in fungi is considered an attractive target for antifungal drugs due to its absence in mammalian hosts. The iron-sulfur cluster-containing enzyme homoaconitase converts homocitrate to homoisocitrate in the lysine biosynthetic pathway, and is encoded by LYS4 in the model yeast Saccharomyces cerevisiae. In this study, we identified the ortholog of LYS4 in the human fungal pathogen, Cryptococcus neoformans, and found that LYS4 expression is regulated by iron levels and by the iron-related transcription factors Hap3 and HapX. Deletion of the LYS4 gene resulted in lysine auxotrophy suggesting that Lys4 is essential for lysine biosynthesis. Our study also revealed that lysine uptake was mediated by two amino acid permeases, Aap2 and Aap3, and influenced by nitrogen catabolite repression (NCR). Furthermore, the lys4 mutant showed increased sensitivity to oxidative stress, agents that challenge cell wall/membrane integrity, and azole antifungal drugs. We showed that these phenotypes were due in part to impaired mitochondrial function as a result of LYS4 deletion, which we propose disrupts iron homeostasis in the organelle. The combination of defects are consistent with our observation that the lys4 mutant was attenuated virulence in a mouse inhalation model of cryptococcosis. PMID:27353379

  7. Application of acid-treated yeast cell wall (AYC) as a pharmaceutical additive. III. AYC aqueous coating onto granules and film formation mechanism of AYC.

    Science.gov (United States)

    Yuasa, Hiroshi; Kaneshige, Junichi; Ozeki, Tetsuya; Kasai, Takahide; Eguchi, Takahiro; Ishiwaki, Naomu

    2002-04-26

    From the viewpoint of effective utilization of natural resources and development of new pharmaceutical materials, acid-treated yeast cell wall (AYC) was prepared via a novel approach involving acidification of brewers' yeast cell wall. AYC aqueous dispersion containing 5% (w/v) AYC and 0.5% (w/v) glycerol was prepared. Subsequently, AYC was coated onto core granules containing acetaminophen (AAP). Spray mist size under various spray conditions and viscosity of the AYC aqueous dispersion at various AYC concentrations were measured. AYC spray mists were optically observed. The surface of AYC cast film and AYC-coated granules were observed with a confocal scanning laser microscope. We attempted to show the utility of AYC as a novel material for granule coating, following the tablet coating in our previous report. In addition, the film formation mechanism of AYC was investigated. A smooth surface of the AYC-coated granules was obtained at a coating ratio of only 5%, which generally requires approximately 15-30% coating against the core granule weight, with no aggregation. These results are attributable to the fact that the granules were coated with a large number of small mists of AYC and the coating progressed efficiently, and the thin film layer of AYC was formed on the granules by mutual tangling of the hydrogel layers of AYC polysaccharides. AAP release from AYC-coated granules was obviously rapid, suggesting the high utility of AYC as a coating material for the rapidly releasing granules.

  8. 毛细支气管炎的临床管理——美国儿科学会临床实践指南简介%Clinical management of bronchiolitis——clinical practice guidelines by American Academy of Pediatrics

    Institute of Scientific and Technical Information of China (English)

    范娟; 李茂军; 吴青; 陈昌辉

    2015-01-01

    毛细支气管炎是婴幼儿常见的一种病毒性下呼吸道感染.近年来,毛细支气管炎的发病率逐年增高,严重影响了儿童身体健康.为了更好地对婴幼儿毛细支气管炎进行管理,美国儿科学会(AAP)以循证医学为依据,对2006年10月发布的毛细支气管炎临床实践指南进行修订,为临床医师提供毛细支气管炎诊断、治疗和预防的新证据.%Bronchiolitis is a common lower respiratory tract viral infection in infants.Incidence of bronchiolitis is greatly increasing in recent years,and seriously affecting the health of children.In order to better manage bronchiolitis,American Academy of Pediatrics (AAP) convened a new subcommittee to review and revise the 2006 bronchiolitis guideline.This evidence-based guideline amended to provide new evidence of diagnosis,treatment and prevention bronchiolitis for the clinician.

  9. Antioxidant activity in selected Slovenian organic and conventional crops

    Directory of Open Access Journals (Sweden)

    Manca KNAP

    2015-12-01

    Full Text Available The demand for organically produced food is increasing. There is widespread belief that organic food is substantially healthier and safer than conventional food. According to literature organic food is free of phytopharmaceutical residues, contain less nitrates and more antioxidants. The aim of the present study was to verify if there are any differences in the antioxidant activity between selected Slovenian organic and conventional crops. Method of DPPH (2,2-diphenyl-1-picryhydrazyl was used to determine the antioxidant activity of 16 samples from organic and conventional farms. The same varieties of crops were analysed. DPPH method was employed to measure the antioxidant activity of polar antioxidants (AAp and antioxidant activity of fraction in ethyl acetate soluble antioxidants (EA AA. Descriptive statistics and variance analysis were used to describe differences between farming systems. Estimated differences between interactions for the same crop and different farming practice were mostly not statistically significant except for the AAp for basil and beetroot. Higher statistically significant values were estimated for conventional crops. For the EA AA in broccoli, cucumber, rocket and cherry statistically significant higher values were estimated for organic production.

  10. Carotenoid charge transfer states and their role in energy transfer processes in LH1-RC complexes from aerobic anoxygenic phototrophs.

    Science.gov (United States)

    Šlouf, Václav; Fuciman, Marcel; Dulebo, Alexander; Kaftan, David; Koblížek, Michal; Frank, Harry A; Polívka, Tomáš

    2013-09-26

    Light-harvesting complexes ensure necessary flow of excitation energy into photosynthetic reaction centers. In the present work, transient absorption measurements were performed on LH1-RC complexes isolated from two aerobic anoxygenic phototrophs (AAPs), Roseobacter sp. COL2P containing the carotenoid spheroidenone, and Erythrobacter sp. NAP1 which contains the carotenoids zeaxanthin and bacteriorubixanthinal. We show that the spectroscopic data from the LH1-RC complex of Roseobacter sp. COL2P are very similar to those previously reported for Rhodobacter sphaeroides, including the transient absorption spectrum originating from the intramolecular charge-transfer (ICT) state of spheroidenone. Although the ICT state is also populated in LH1-RC complexes of Erythrobacter sp. NAP1, its appearance is probably related to the polarity of the bacteriorubixanthinal environment rather than to the specific configuration of the carotenoid, which we hypothesize is responsible for populating the ICT state of spheroidenone in LH1-RC of Roseobacter sp. COL2P. The population of the ICT state enables efficient S1/ICT-to-bacteriochlorophyll (BChl) energy transfer which would otherwise be largely inhibited for spheroidenone and bacteriorubixanthinal due to their low energy S1 states. In addition, the triplet states of these carotenoids appear well-tuned for efficient quenching of singlet oxygen or BChl-a triplets, which is of vital importance for oxygen-dependent organisms such as AAPs. PMID:23130956

  11. Spatial Variation of the Relationship between PM2.5 Concentrations and Meteorological Parameters in China

    Directory of Open Access Journals (Sweden)

    Gang Lin

    2015-01-01

    Full Text Available Epidemiological studies around the world have reported that fine particulate matter (PM2.5 is closely associated with human health. The distribution of PM2.5 concentrations is influenced by multiple geographic and socioeconomic factors. Using a remote-sensing-derived PM2.5 dataset, this paper explores the relationship between PM2.5 concentrations and meteorological parameters and their spatial variance in China for the period 2001–2010. The spatial variations of the relationships between the annual average PM2.5, the annual average precipitation (AAP, and the annual average temperature (AAT were evaluated using the Geographically Weighted Regression (GWR model. The results indicated that PM2.5 had a strong and stable correlation with meteorological parameters. In particular, PM2.5 had a negative correlation with precipitation and a positive correlation with temperature. In addition, the relationship between the variables changed over space, and the strong negative correlation between PM2.5 and the AAP mainly appeared in the warm temperate semihumid region and northern subtropical humid region in 2001 and 2010, with some localized differences. The strong positive correlation between the PM2.5 and the AAT mainly occurred in the mid-temperate semiarid region, the humid, semihumid, and semiarid warm temperate regions, and the northern subtropical humid region in 2001 and 2010.

  12. Ask, advise, assist: pediatricians and passive smoke exposure.

    Science.gov (United States)

    Burnett, K F; Young, P C

    1999-06-01

    The objectives of this study were to determine: (1) how frequently pediatricians obtain a history of passive smoke exposure (PSE), (2) what type of advice regarding PSE they offer and how frequently they offer it, and (3) what methods and what assistance they believe would be useful to reduce PSE. A random sample of 1,000 US members (GEN) of the American Academy of Pediatrics (AAP) and all 724 members of the AAP sections of pulmonology, otolaryngology, and allergy (SPECS) were sent a questionnaire. Seven hundred fifty-five usable questionnaires were returned. Ninety-six percent of 321 general pediatricians obtained a PSE history at least "sometimes" but were much more likely to "always" do so when seeing a patient with asthma (87%) or recurrent otitis media (56%) than during well-child visits (41%) (p smoke around the child," or "quit smoking." Reasons for not initiating a cessation program included lack of skills (38%) or time (36%) or a belief that it was "not their responsibility" (13%). Pediatricians indicated that brochures for parents that describe the hazards of PSE and contain specific information regarding how to refer to community smoking cessation programs would be of most use to them in helping parents reduce PSE to their children. Pediatricians frequently ask about PSE and advise reducing it but seldom assist parents with specific advice regarding effective methods to quit smoking.

  13. Effects of Aconitine on [Ca2+] Oscillation in Cultured Myocytes of Neonatal Rats

    Institute of Scientific and Technical Information of China (English)

    Yah LIU; Shiwei ZHANG; Man LIANG; Qian LIU; Liang LIU

    2008-01-01

    Summary: In order to investigate the effects of aconitine on [Ca2+] oscillation patterns in cultured myocytes of neonatal rats, fluorescent Ca2+ indicator Fluo-4 NW and laser scanning confocal microscope (LSCM) were used to detect the real-time changes of [Ca2+] oscillation patterns in the cultured myocytes before and after aconitine (1.0 μmol/L) incubation or antiarrhythmic peptide (AAP) and aconitine co-incubation. The results showed under control conditions, [Ca2+] oscillations were irregular but relatively stable, occasionally accompanied by small calcium sparks. After incubation of the cultures with aconitine, high frequency [Ca2+] oscillations emerged in both nuclear and cytoplasmic regions, whereas typical calcium sparks disappeared and the average [Ca2+] in the cytoplasm of the cardiomyocyte did not change significantly. In AAP-treated cultures, intraecllular [Ca2+] oscillation also changed, with periodic frequency, increased amplitudes and prolonged duration of calcium sparks. These patterns were not altered significantly by subsequent aconitine incubation. The basal value of [Ca2+] in nuclear region was higher than that in the cytoplasmic region, in the presence or absence of drugs, the [Ca2+] oscillated synchronously in both the nuclear and cytoplasmic regions of the same cardiomyocyte. It was concluded that although oscillating strenuously at high frequency, the average [Ca2+] in the cytoplasm of cardiomyocyte did not change significantly after aconitine incubation, compared to the controls. The observations indicate that aconitine induces the changes in [Ca2+] oscillation frequency other than the Ca2+ overload.

  14. Organic Phosphorus in Shallow Lake Sediments in Middle and Lower Reaches of the Yangtze River Area in China

    Institute of Scientific and Technical Information of China (English)

    JIN Xiang-Can; WANG Sheng-Rui; CHU Jian-Zhou; WU Feng-Chang

    2008-01-01

    Thirteen sediment core samples (0-10 cm) were taken from the seven lakes in the middle and lower reaches of the Yangtze River to determine the contents and distributions of organic phosphorus (P) fractions in the sediments of the shallow lakes in the area.The organic P fractions in the sediments were in the order of moderately labile organic P (MLOP) > moderately resistant organic P (MROP) > highly resistant organic P (HROP) > labile organic P (LOP),with average proportional ratios of 13.2:2.8:1.3:1.0.LOP,MLOP,and MROP were significantly related to the contents of total organic carbon (TOC),water-soluble P (WSP),algal-available P (AAP),NaHCO3-extractable P (Olsen-P),total P (TP),organic P (OP),and inorganic P (IP).However,HROP was significantly related to OP and weakly correlated with TOC,WSP,AAP,Olsen-P,TP or IP.This suggested that organic P,especially LOP and MLOP in sediments,deserved even greater attention than IP in regards to lake eutrophication.In terms of organic P,sediments were more hazardous than soils in lake eutrophication.Although OP concentrations were higher in moderately polluted sediment than those in heavily polluted sediment,LOP and MLOP were higher in the heavily polluted sediment,which indicated that heavily polluted sediment was more hazardous than moderately polluted sediment in lake eutrophication.

  15. Measuring diagnostic accuracy of imaging parameters in pelvic lipomatosis

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yudong, E-mail: pku_zyd06@163.com [Department of Radiology, Peking University First Hospital, Beijing (China); Wu, Shiliang, E-mail: wushiliangjsh@263.net [Department of Urology, Peking University First Hospital, Beijing (China); Xi, Zhijun, E-mail: xizhijun@hsc.pku.edu.cn [Department of Urology, Peking University First Hospital, Beijing (China); Wang, Xiaoying, E-mail: cjr.wangxiaoying@vip.163.com [Department of Radiology, Peking University First Hospital, Beijing (China); Jiang, Xuexiang, E-mail: cjr.jxx@vip.163.com [Department of Radiology, Peking University First Hospital, Beijing (China)

    2012-11-15

    Objectives: To study whether the individual radiological findings can help predict diagnosis of pelvic lipomatosis (PL) or, specifically appreciate its progression. Methods: Data from 32 clinically proven cases of PL and 25 controls were collected. Two reviewers were recruited for a blinded evaluation, image features were recorded in terms of: (1) bladder shape; (2) bladder-rectosigmoid morphological indexes including ratio of superior-inferior to anterior-posterior length of bladder (SI/AP), angle between anterior and posterior wall (AAP), relative length of posterior urethra (rLPU), angle between bladder and seminal vesicle (ABS) and rectosigmoid morphological index (RMI); (3) secondary complications. Results were evaluated by an unpaired t test and ROC analysis. Results: The sensitivity and specificity were 40.6% and 100% for pear and banana-shaped bladder, 62.5% and 100% for SI/AP, 40.6% and 100% for AAP, 62.5% and 100% for ABS, 78.1% and 72% for rLPU, 59.4% and 96% for RMI, respectively. These radiological findings partially correlated with the severity of disease weighted by hydronephrosis and treatment grade. Image analysis demonstrated high prevalence of glandular cystitis (100%) and hydronephrosis (73.4%). Conclusion: We conclude that PL is a progressive disease involving multiple pelvic organs with high prevalence of intractable cystitis and hydronephrosis. The imaging characteristics can help predict diagnosis and, specifically appreciate progression.

  16. Soil sorption and plant uptake of 2,4,6-trinitrotoluene

    Energy Technology Data Exchange (ETDEWEB)

    Pennington, J.C.

    1988-01-01

    Potential environmental hazards are posed by the presence of 2,4,6-trinitrotoluene (TNT) contamination in soils of US Army Ammunition Plants (AAPs). Adsorption and desorption studies were conducted on soil samples collected from 13 AAPs. TNT adsorption correlated most highly with cation exchange capacity, extractable iron, clay content, and percent organic carbon. Sequential desorption indicated that almost all of the adsorbed TNT was desorbed after three sequential desorption cycles. Plant uptake of TNT and two of its principal degradation products, 4-amino-2,6-dinitrotoluene (4ADNT) and 2-amino-4,6-dinitrotoluene (2ADNT), was also investigated. Results indicated that little TNT and 4ADNT, and no 2ADNT was absorbed by leafy portions of the test plant, yellow nutsedge (Cyperus esculentus). Plant uptake was greatest from 4ADNT-treated silts, an indication that 4ADNT is more readily mobilized into the plant than TNT or 2ANDT. Greater plant uptake from silt than from clay indicated that bioavailability is reduced in the clay. The reduction in bioavailability may be due to an increase in soil sorption of TNT and its degradation products over time.

  17. Determination of Mercury (II Ion on Aryl Amide-Type Podand-Modified Glassy Carbon Electrode

    Directory of Open Access Journals (Sweden)

    Sevgi Güney

    2011-01-01

    Full Text Available A new voltammetric sensor based on an aryl amide type podand, 1,8-bis(o-amidophenoxy-3,6-dioxaoctane, (AAP modified glassy carbon electrode, was described for the determination of trace level of mercury (II ion by cyclic voltammetry (CV and differential pulse voltammetry (DPV. A well-defined anodic peak corresponding to the oxidation of mercury on proposed electrode was obtained at 0.2 V versus Ag/AgCl reference electrode. The effect of experimental parameters on differential voltammetric peak currents was investigated in acetate buffer solution of pH 7.0 containing 1 × 10−1 mol L−1 NaCl. Mercury (II ion was preconcentrated at the modified electrode by forming complex with AAP under proper conditions and then reduced on the surface of the electrode. Interferences of Cu2+, Pb2+, Fe3+, Cd2+, and Zn2+ ions were also studied at two different concentration ratios with respect to mercury (II ions. The modified electrode was applied to the determination of mercury (II ions in seawater sample.

  18. Formas agudas de periodontitis Acute conditions of periodontal disease

    Directory of Open Access Journals (Sweden)

    L. Pérez-Salcedo

    2008-04-01

    Full Text Available La clasificación de las Enfermedades Periodontales ha cambiado en las últimas décadas. En la clasificación la AAP de 1989 la periodontitis necrotizante ocupaba el cuarto lugar. En el Workshop Europeo de 1993 la periodontitis necrotizante aparece en el grupo de los descriptores primarios. Según el Internacional Workshop for a Classification of Periodontal Diseases and Conditions 1999 en el que se revisó y se modificó la clasificación de las patologías periodontales, las enfermedades periodontales necrotizantes ocupan el punto cinco, diferenciándose entre Gingivitis Necrotizante y Periodontitis Necrotizante. Y se añade en la clasificación el grupo de abscesos periodontales. En este artículo de revisión vamos a profundizar acerca de las formas agudas de periodontitis.The Periodontal Diseases classification had changed in the last decades. In AAP classification of 1989 the necrotize was in the 4th position. In the European Workshop was in the group of primary descriptors. According to the International Workshop for a Classification of Periodontal Diseases and Conditions 1999, review and modificated the classification of periodontal pathologies, the periodontal necrotize diseases are in the 5th position, distinguishing between Necrotize Gingivitis and Necrotize Periodontitis. And Peridontal Abscesses was add to the classification. In this paper we are going to review about the acute forms of Periodontal Diseases.

  19. Novel routes to metalloorganics containing aluminum from minerals

    Science.gov (United States)

    Narayanan, Ramasubramanian

    Novel pathways for synthesizing Al metalloorganics directly from widely available oxides and oxo-hydroxides of aluminum are developed. The Al metalloorganics are then used to produce low-cost precursors for ceramics and polymers containing Al. Alumatrane, an unique, air-stable, aluminum alkoxide is prepared in one step from aluminum hydroxide in quantitative yields. Subsequently, alumatrane was used to prepare and characterize all group II dialuminate ceramics (MAlsb2Osb4, M = Mg, Ca, Sr, Ba). Similarly, an air-stable alkoxide of silicon was synthesized directly from SiOsb2, and is used in conjunction with alumatrane to produce precursors for aluminosilicate ceramics (MAlSiOsb4, M = K, Li, Na). Aluminum formate is synthesized, in differing efficiencies, from different crystalline minerals of Al, by direct dissolution in formic acid. A few other aluminum carboxylates are also synthesized, either directly from minerals or from aluminum formates, thus expanding the scope of the acid dissolution of aluminum hydroxides. Aluminum allyloxypropanoate (AAP) (Al(Osb2CCHsb2CHsb2OCH{=}CHsb2)sb2(OH)), an aluminum carboxylate with a polymerizable group has been synthesized from aluminum formate. This, has been incorporated into methyl methacrylate (MMA) polymers to impart fire retardancy. The increase in char yields as a result of AAP incorporation, indicate improved fire retardancy. Fire retardant characteristics of alumatrane has also been investigated, in MMA polymers and in a polyurethane polymer, taking char yields as a measure of fire retardance efficiency.

  20. Herpesviruses and breast milk

    Directory of Open Access Journals (Sweden)

    C. Pietrasanta

    2014-06-01

    Full Text Available Breast milk has always been the best source of nourishment for newborns. However, breast milk can carry a risk of infection, as it can be contaminated with bacterial or viral pathogens. This paper reviews the risk of acquisition of varicella-zoster virus (VZV and cytomegalovirus (CMV, herpesviruses frequently detected in breastfeeding mothers, via breast milk, focusing on the clinical consequences of this transmission and the possible strategies for preventing it. Maternal VZV infections are conditions during which breastfeeding may be temporarily contraindicated, but expressed breast milk should always be given to the infant. CMV infection acquired through breast milk rarely causes disease in healthy term newborns; an increased risk of CMV disease has been documented in preterm infants. However, the American Academy of Pediatrics (AAP does not regard maternal CMV seropositivity as a contraindication to breastfeeding; according to the AAP, in newborns weighing less than 1500 g, the decision should be taken after weighing the benefits of breast milk against the risk of transmission of infection. The real efficacy of the different methods of inactivating CMV in breast milk should be compared in controlled clinical trials, rigorously examining the negative consequences that each of these methods can have on the immunological and nutritional properties of the milk itself, with a view to establish the best risk-benefit ratio of these strategies before they are recommended for use in clinical practice.

  1. A forward to optimization of antivenom therapy: An in vivo study upon the effectiveness of the antivenom against early and delayed nephrotoxicity induced by the venom of the Iranian scorpion Hemiscorpius lepturus in rat.

    Science.gov (United States)

    Pipelzadeh, Mohammad Hassan; Jalali, Amir; Dezfulian, Abdul Rahman; Khorasgani, Zahra Nazari; Sarvestani, Somie; Ghalambor, Amir Hossein; Azarpanah, Armita

    2015-06-15

    The aim of the present in vivo study was to identify the optimal effective dose, the most favorable time and the route of administration of the available polyvalent scorpion antivenom against the toxic effects induced by Hemiscorpius lepturus (H. lepturus) venom in rat. The end point for assessment included measurement of alanin-amino-peptidase (AAP) and N-acetyl-b-d-glucosaminidase (NAG), biochemical urine analysis and histopathological assessment. The results showed that a single subcutaneous 50 μg of the venom produced significant increase in the AAP and NAG enzyme activity, urinary biochemical parameters and induced histopathological structural abnormalities in the renal system. The optimal effective co-administered dose of the antivenom was 0.5 ml, which when administered 1 and 2 h of envenomation by intravenous (IV) and subcutaneous (SC) routes respectively produced significant protection against these toxic effects. Prudently, the significance of these findings need to be assessed in further clinical studies. PMID:25847302

  2. Optimising contributions of goat farming to household economic success and food security in three production systems in Ethiopia

    Directory of Open Access Journals (Sweden)

    Tatek Woldu

    2016-03-01

    Full Text Available The study aims to analyse factors affecting contributions of goat farming to household economic success and food security in three goat production systems of Ethiopia. A study was conducted in three districts of Ethiopia representing arid agro-pastoral (AAP, semi-arid agro-pastoral (SAAP and highland mixed crop-livestock (HMCL systems involving 180 goat keeping households. Gross margin (GM and net benefit (NB1 and NB2 were used as indicators of economic success of goat keeping. NB1 includes in-kind benefits of goats (consumption and manure, while NB2 additionally constitutes intangible benefits (insurance and finance. Household dietary diversity score (HDDS was used as a proxy indicator of food security. GM was significantly affected by an off-take rate and flock size interaction (P0.05. Nevertheless, a significant positive correlation (P<0.05 was observed between GM from goats and HDDS in AAP system, indicating the indirect role of goat production for food security. The study indicated that extent of utilising tangible and intangible benefits of goats varied among production systems and these differences should be given adequate attention in designing genetic improvement programs.

  3. Accelerated automatic phase shift method for DG anti-islanding%分布式发电反孤岛控制的自动加速相移方法

    Institute of Scientific and Technical Information of China (English)

    张榴晨; Mary Kaye; Chris Diduch; 尹俊

    2014-01-01

    分布式发电反孤岛技术的最新研究进展表明,相移法能有效用于具有逆变器的分布式发电系统反孤岛保护。介绍滑模频率偏移(SMS)、主动频率偏移(AFD)和带正反馈的主动频率偏移(AFDPF)。自动相移法(APS)是一种改进的 SMS法,减少了 SMS的测区盲区(NDZ)。但稳定孤岛效应的频率确定困难,而且 APS运行慢,并可能在某些特定条件下失效。基于目前存在的难题,该文提出一种改进的自动加速相移算法(AAPS),矫正孤岛效应下的附加相位漂移,评价总电压相位漂移对电压周期的影响。该算法在孤岛发生时,会引起快速的相移,但在电网互联时只会引起极小的相位。孤岛发生时,该算法通过逆变器相移正反馈实现。仿真和实验结果证明了 AAPS算法的有效性。先进的 AAPS已经被应用于风能和太阳能系统的商业并网逆变器中,并符合 UL/CSA认证标准要求。各种条件下的认证测试结果表明 APPS算法可以在极短的时间内断开逆变器。%Recent developments in anti-islanding techniques have demonstrated that phase shift methods are very effective for anti-islanding protection in inverter-based distributed generation (DG)systems.Slide-mode frequency shift (SMS),active frequency drift (AFD),and active fre-quency drift with positive feedback (AFDPF)are presented in this paper.The automatic phase shift (APS)method is a modified SMS method that reduces the Non-Detection Zone (NDZ)of the SMS technique.However,it is difficult to determine a stable islanding frequency,and the APS algorithm may act slowly or fail under certain load conditions.An improved accelerated au-tomatic phase shift (AAPS)algorithm is proposed in this paper to regulate the additional phase shift when an island condition is hypothesized and to evaluate the impact of the total phase shift on the voltage period .The new algorithm causes a quick phase shift when an island occurs

  4. 急诊科醉酒患者血清hs-CRP水平、NLR及EPIC评分对急性胰腺炎的诊断价值%The Value of Serum Hs-CRP Level NLR and EPIC Score for the Diagnosis of Acute Pancreatitis in Alcoholism Patients in Emergency Department

    Institute of Scientific and Technical Information of China (English)

    王书强; 张晓兰

    2015-01-01

    Objective To study the value of serum hs-CRP level NLR and EPIC score for the diagnosis of acute pancreatitis in alcoholism patients with emergency department. Method 100 cases of alcoholism patients in our hospital from January 2013-December 2014 were selected, including 38 patients with AAP as observation group, 62 cases of patients without the AAP as control group, all patients received blood tests and abdominal CT examination within 24h admitted to hospital, compared the serum hs-CRP levels, NLR and EPIC scale of the two groups of patients, analysis the relationship between three indicators and AAP illness severity. Results The proportion of male patients, proportion of SAP patients, the serum hs-CRP levels, NLR and EPIC score of the observing group were higher than the control group, the age of the observation group was younger than those in control group, the difference has statistical signiifcance (all P<0.05). Conclusion AAP occurs in young and middle-aged men, its has high incidence of SAP, its serum hs-CRP levels, NLR and EPIC score was higher than the non-AAP patients;the serum hs-CRP levels, NLR and EPIC scale can be used as the effective index response the severity of the alcoholism patients.%目的:探讨急诊科醉酒患者血清hs-CRP水平、NLR(中性粒细胞与淋巴细胞比值)及EPIC(胰腺外炎症CT评分)对急性胰腺炎(AAP)的诊断价值及与病情严重程度的关系。方法选取2013年1月至2014年12月我院收治的醉酒患者100例,其中AAP患者38例作为观察组,非AAP患者62例作为对照组,所有患者入院24 h内进行血液检验及腹部CT检查,对比两组患者的血清hs-CRP水平、NLR及EPIC评分,分析三项指标与AAP病情严重性的关系。结果观察组男性患者比例、血清hs-CRP水平、NLR及EPIC评分较对照组高,观察组患者年龄较对照组轻,差异具有统计学意义(均P<0.05)。结论醉酒患者中,AAP好发于中青年男性,其重

  5. Diarrheagenic Escherichia coli carrying supplementary virulence genes are an important cause of moderate to severe diarrhoeal disease in Mexico.

    Directory of Open Access Journals (Sweden)

    Sandra Patzi-Vargas

    2015-03-01

    Full Text Available Diarrheagenic Escherichia coli (DEC cause acute and persistent diarrhoea worldwide, but little is known about their epidemiology in Mexico. We determined the prevalence of bacterial enteropathogens in 831 children with acute diarrhoea over a four-year period in Yucatan, Mexico. Six DEC supplementary virulence genes (SVG, mainly associated with enteroaggregative E. coli (EAEC, were sought in 3100 E. coli isolates. DEC was the most common bacterial enteropathogen (28%, surpassing Salmonella (12% and Shigella (9%. Predominant DEC groups were diffusely adherent E. coli (DAEC (35%, EAEC (24%, and enteropathogenic E. coli (EPEC (19%. Among children with DEC infections, 14% had severe illness mainly caused by EPEC (26% and DAEC (18%; 30% had moderate diarrhoea mainly caused by DAEC (36%, mixed DEC infections (33% and EAEC (32%. DAEC was most prevalent during spring, while ETEC, EAEC and EPEC predominated in summer. EAEC was more frequent in children 6-24 months old than in those younger than 6 months of age (P = 0.008, OR = 4.2, 95% CI, 1.3-13.9. The presence of SVG dispersin, (aatA, dispersin-translocator (aatA, enteroaggregative heat-stable toxin 1 (astA, plasmid encoded toxin (pet, cytolethal distending toxin (cdt was higher in DEC than non-DEC strains, (36% vs 26%, P <0.0001, OR = 1.5, 95% CI, 1.3-1.8. 98% of EAEC-infected children harboured strains with SVG; 85% carried the aap-aatA gene combination, and 33% of these also carried astA. 28% of both EPEC and ETEC, and 6% of DAEC patients had strains with SVG. 54% of EPEC patients carried pet-positive strains alone or in combination with astA; only this DEC group harboured cdt-positive isolates. All ETEC patients carried astA- or astA-aap-positive strains. astA and aap were the most common SVG in DAEC (3% and 2% and non-DEC strains (21% and 13%. DEC carrying SVG are an important cause of moderate to severe bacterial diarrhoea in Mexican children.

  6. Time Ephemeris and Relativistic Scaling of Ephemerides

    Science.gov (United States)

    Fukushima, Toshio

    2009-05-01

    Time ephemeris is the location-independent part of the transformation formula relating two time coordinates such as TCB and TCG. It is computed from the corresponding (space) ephemerides providing the relative motion of two spatial coordinate origins associated such as the motion of geocenter relative to the solar system barycenter. The time ephemerides are inevitablly needed in conducting a precise four-dimensional coordinate transformation among various spacetime coodrinate systems such as the GCRS and BCRS. Also, by means of the time average operation, it is useful in determining the information on scale conversion between the pair of coordinate systems, especially scale conversion factors such as LC. In 1995, we presented the first numerically-integrated time ephemeris, TE245, from JPL's planetary ephemeris DE245 (Fukushima 1995, A&Ap, 294, 895-906). Four years later, we updated it to TE405 associated with DE405 (Irwin and Fukushima 1999, A&Ap, 348, 642-652). The former gave an estimate of LC, the scale conversion factor between TCB and TCG, as 1.4808268457(10) x 10-8. Meanwhile the latter renewed it as 1.48082686741(200) x 10-8. Another four years later, by using a precise technique of time avarage, we improved the estimate as 1.4808268559(6) x 10-8 (Harada and Fukushima 2003, AJ, 126, 2557-2561). The main reasons of these uncertainties are the truncation effect in time average and the uncertainty of asteroids' perturbation. The former is a natural limitation caused by the finite length of numerical planetary ephemerides and the latter is due to the uncertainty of masses of some heavy asteroids. In the talk, we review the post-Newtonian formulas to integrate time ephemerides as well as some practical details on their numerical integration. Also, we explain two kinds of techniques of time average. One is a semi-numerical approach as explained in 1991 A&Ap article and the other is purely numerical as given in 2003 AJ paper.

  7. [The role of tubulointerstitial changes in progression of kidney function failure in patients with chronic glomerulonephritis (GN)].

    Science.gov (United States)

    Idasiak-Piechocka, I; Krzymański, M

    1996-01-01

    In most cases of glomerulonephritis (GN) long-term course lead to chronic renal failure. The cause of inevitably gradually progress of GN to end-stage renal disease (ESRD) is unclear. The histological abnormalities seen in patients with progressive renal failure consist of focal and segmental glomerulosclerosis and tubulointerstitial nephritis. At present it is considered that tubulointerstitial changes attends almost all forms of progressive glomerular and vascular injury. It was known that chronic tubulointerstitial nephritis is characterized morphologically by tubular atrophy, interstitial fibrosis and interstitial inflammation of variable severity. The pathomechanism of this changes is complicated. Tubular ischaemia results from obliteration of peritubular capillaries, adaptation of tubular function with increased oxygen consumption and increased glomerular capillary permeability to macromolecules are reasons of chronic tubular damage. Injured tubules release growth factors and cytokines, which induce interstitial fibroblast proliferation, chemo-attraction and proliferation of infiltrating cells, and disruption of the balance between synthesis and degradation of cellular constituents. The consequences of these processes are tubular atrophy and interstitial fibrosis. Because of many studies concurred that tubulointerstitial changes determinant the progression of GN, tubular injury markers were searched for. Although over 50 enzymes were detected in human urine, only a few have been used for diagnosis in renal disease. The most widely used are lysosomal enzyme N acetyl-beta-D-glucosaminidase (NAG) and brush border enzymes alanine-aminopeptidase (AAP) and gamma-glutamyltransferase (GGT). tubular damage in hypertension, diabetes and in diagnostics of renal disease. AAP and GGT, brush border enzymes seem to be sensitive markers of renal injury too. Pathological value of GGT was observed even in the early stage of disease. Measurement of urinary excretion of low

  8. The impact of compulsory cycle helmet legislation on cyclist head injuries in New South Wales, Australia: a rejoinder.

    Science.gov (United States)

    Rissel, Chris

    2012-03-01

    This paper challenges the conclusion of a recent paper by Walter et al. (Accident Analysis and Prevention 2011, doi:10.1016/j.aap.2011.05.029) reporting that despite numerous data limitations repealing the helmet legislation in Australia could not be justified. This conclusion is not warranted because of the limited time period used in their analysis and the lack of data beyond a few years before the introduction of legislation, the failure to adequately account for the effect of the phasing in of the legislation, the effect of the marked reduction in child cyclists, and the non-comparability of the pedestrian and cycling injuries and related lack of consideration of the severity of head injuries. The extent to which helmet legislation deters people from cycling is discussed. PMID:22269491

  9. Cell wall bound anionic peroxidases from asparagus byproducts.

    Science.gov (United States)

    Jaramillo-Carmona, Sara; López, Sergio; Vazquez-Castilla, Sara; Jimenez-Araujo, Ana; Rodriguez-Arcos, Rocio; Guillen-Bejarano, Rafael

    2014-10-01

    Asparagus byproducts are a good source of cationic soluble peroxidases (CAP) useful for the bioremediation of phenol-contaminated wastewaters. In this study, cell wall bound peroxidases (POD) from the same byproducts have been purified and characterized. The covalent forms of POD represent >90% of the total cell wall bound POD. Isoelectric focusing showed that whereas the covalent fraction is constituted primarily by anionic isoenzymes, the ionic fraction is a mixture of anionic, neutral, and cationic isoenzymes. Covalently bound peroxidases were purified by means of ion exchange chromatography and affinity chromatography. In vitro detoxification studies showed that although CAP are more effective for the removal of 4-CP and 2,4-DCP, anionic asparagus peroxidase (AAP) is a better option for the removal of hydroxytyrosol (HT), the main phenol present in olive mill wastewaters.

  10. Dicty_cDB: SHL892 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ig-n mRNA for phosphatidylinositolglycan class N, complete cds. 62 2e-12 2 DY294852 |DY294852.1 IC0AAA86CG03RM1 CitNFL Citrus clement...8.1 IC0AAA7DH07RM1 CitNFL Citrus clementina cDNA 5', mRNA sequence. 84 5e-12 1 DY261328 |DY261328.1 KN0AAP2Y...H23FM1 Fruit-TF Citrus clementina cDNA 5', mRNA sequence. 84 5e-12 1 CX290998 |CX290998.1 C03002G05Rv OF1 Citrus clement

  11. Dicty_cDB: Contig-U05401-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ne R3-17H6, WORK... 44 4.9 1 ( ET102311 ) QM0AAB20CB11RM1 CCER1 Citrus clementina genomic c... 44 4.9 1 ( ET...102010 ) QM0AAB20AB11RM1 CCER1 Citrus clementina genomic c... 44 4.9 1 ( ET091472... ) QM0AAA16DG01FM1 CCL1 Citrus clementina genomic cl... 44 4.9 1 ( AQ142377 ) HS_3076_B1_H01_MF CIT Approved...4 4.9 1 ( DY260859 ) KN0AAP13YN03FM1 Fruit-TF Citrus clementina cDNA 5... 44 4.9 1 ( CB557235 ) AMGNNUC:NRHY

  12. Dicty_cDB: SHL677 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available osphatidylinositolglycan class N, complete cds. 62 6e-12 2 DY294852 |DY294852.1 IC0AAA86CG03RM1 CitNFL Citrus clement...ina cDNA 5', mRNA sequence. 84 9e-12 1 DY292438 |DY292438.1 IC0AAA7DH07RM1 CitNFL Citrus clementina... cDNA 5', mRNA sequence. 84 9e-12 1 DY261328 |DY261328.1 KN0AAP2YH23FM1 Fruit-TF Citrus clementina cDNA 5', ...mRNA sequence. 84 9e-12 1 CX290998 |CX290998.1 C03002G05Rv OF1 Citrus clementina

  13. Gene : CBRC-GGOR-01-1364 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available bradykinin receptor B1 [Homo sapiens] sp|P46663|BKRB1_HUMAN RecName: Full=B1 bradykinin receptor; AltName: ...Full=BK-1 receptor; Short=B1R emb|CAB45650.1| bradykinin B1 receptor [Homo sapiens] dbj|BAC06112.1| seven tr...ansmembrane helix receptor [Homo sapiens] gb|AAH34705.1| Bradykinin receptor B1 [Homo sapi...ens] gb|AAP32296.1| bradykinin receptor B1 [Homo sapiens] gb|EAW81632.1| bradykinin receptor B1 [Homo sapi...1 [synthetic construct] dbj|BAF84659.1| unnamed protein product [Homo sapiens] 1e

  14. Exploring teacher influence on the lives of students from diverse elementary schools in a rural Midwestern community

    OpenAIRE

    Knoell, Christopher M.; Crow, Sherry R.

    2013-01-01

    Įvadas. Praktikai ir mokslininkai mokinių pažangumo ir adekvataus ankstyvo progreso (AAP) srityje ieško strategijų, kaip palaikyti tinkamą mokinių akademinę pažangą. Viena iš sričių, kurioje praktikai galėtų gauti daugiau informacijos, – mokytojų ir mokinių santykiai skirtingo tipo mokyklose ir situacijose arba tais atvejais, kai mokinių gebėjimai yra skirtingi. Tikslas. Šio tyrimo tikslas – palyginti, kokį poveikį mokytojai turi skurdžiai ir turtingai gyvenančių vaikų mokyklų penktos klasės ...

  15. Asociación entre niveles de TNF-α en fluido crevicular gingival de dientes con periodontitis apical asintomática Levels of TNF-α increase in gingival crevicular fluid of teeth with asymptomatic apical periodontitis

    Directory of Open Access Journals (Sweden)

    M Garrido Flores

    2011-12-01

    resorption, a hallmark of asymptomatic apical periodontitis (AAP. Gingival crevicular fluid (GCF has a great potential as a source of factors associated with osteoclastic activity. The aim of this study was to determine the levels of TNF- a in GCF of teeth with PAA and contralateral healthy controls. Methods: A total of 14 patients with clinical diagnosis of AAP were enrolled from the Clinic of Endodontics, Faculty of Dentistry, Universidad de Chile during 2009 and 30-second GCF samples were obtained with paper strips from AAP teeth and contralateral healthy controls. Total protein concentration and TNF- a levels were determined through bisciconitic acid method and ELISA assay, respectively. Paired t test and StataV11 software were used for statistical analysis. Results: Levels of TNF- a were significantly higher in GCF from teeth with AAP than controls when standardized by either 30s of sampling and total protein content. Conclusions: The present study provides preliminary data supporting that TNF- a levels in GCF reflect periapical status. Screening of TNF- a levels in GCF might represent a useful side-diagnostic tool to the monitoring of the apical status.

  16. 何谓肠出血性大肠杆菌O104:H4及防治%What is enterohemorrhagic Escherichia coli O104:H4 and how to prevent

    Institute of Scientific and Technical Information of China (English)

    任成山; 赵晓晏

    2011-01-01

    @@ 所谓肠出血性大肠杆菌O104:H4(enterohemorrhagic E.coli,O104:H4),是由德国分离的一种新菌珠O104:H4型大肠杆菌,含有志贺毒素2(vtx2a)的基因,没有(enterohemorrhagic Escherichia coli,EHEC)溶血素、志贺毒素1、肠致病性大肠埃希菌(enteropathogenic Escherichia coli)基因毒力岛基因;但含有肠集聚性粘附大肠杆菌(enteroaggragtive Escherichia coli)(第5类致泻性大肠杆菌)毒力质粒上的3个基因:aatA、aggR、aap[1].

  17. An Arginine Deprivation Response Pathway Is Induced in Leishmania during Macrophage Invasion.

    Directory of Open Access Journals (Sweden)

    Adele Goldman-Pinkovich

    2016-04-01

    Full Text Available Amino acid sensing is an intracellular function that supports nutrient homeostasis, largely through controlled release of amino acids from lysosomal pools. The intracellular pathogen Leishmania resides and proliferates within human macrophage phagolysosomes. Here we describe a new pathway in Leishmania that specifically senses the extracellular levels of arginine, an amino acid that is essential for the parasite. During infection, the macrophage arginine pool is depleted due to its use to produce metabolites (NO and polyamines that constitute part of the host defense response and its suppression, respectively. We found that parasites respond to this shortage of arginine by up-regulating expression and activity of the Leishmania arginine transporter (LdAAP3, as well as several other transporters. Our analysis indicates the parasite monitors arginine levels in the environment rather than the intracellular pools. Phosphoproteomics and genetic analysis indicates that the arginine-deprivation response is mediated through a mitogen-activated protein kinase-2-dependent signaling cascade.

  18. An Arginine Deprivation Response Pathway Is Induced in Leishmania during Macrophage Invasion.

    Science.gov (United States)

    Goldman-Pinkovich, Adele; Balno, Caitlin; Strasser, Rona; Zeituni-Molad, Michal; Bendelak, Keren; Rentsch, Doris; Ephros, Moshe; Wiese, Martin; Jardim, Armando; Myler, Peter J; Zilberstein, Dan

    2016-04-01

    Amino acid sensing is an intracellular function that supports nutrient homeostasis, largely through controlled release of amino acids from lysosomal pools. The intracellular pathogen Leishmania resides and proliferates within human macrophage phagolysosomes. Here we describe a new pathway in Leishmania that specifically senses the extracellular levels of arginine, an amino acid that is essential for the parasite. During infection, the macrophage arginine pool is depleted due to its use to produce metabolites (NO and polyamines) that constitute part of the host defense response and its suppression, respectively. We found that parasites respond to this shortage of arginine by up-regulating expression and activity of the Leishmania arginine transporter (LdAAP3), as well as several other transporters. Our analysis indicates the parasite monitors arginine levels in the environment rather than the intracellular pools. Phosphoproteomics and genetic analysis indicates that the arginine-deprivation response is mediated through a mitogen-activated protein kinase-2-dependent signaling cascade. PMID:27043018

  19. Molecular characterization of an early invasive Staphylococcus epidermidis prosthetic joint infection.

    Science.gov (United States)

    Rosenthal, Marnie E; Dever, Lisa L; Moucha, Calin S; Chavda, Kalyan D; Otto, Michael; Kreiswirth, Barry N

    2011-09-01

    Historically regarded as a skin commensal, Staphylococcus epidermidis has been increasingly implicated in invasive foreign body infections such as catheter-related bloodstream infections, indwelling device infections, and prosthetic joint infections. We report a case of an aggressive, difficult-to-eradicate, invasive prosthetic hip infection occurring early after hardware implant and associated with a high-grade bacteremia and assess its salient molecular characteristics. The clinical and molecular characteristics of this isolate mirror the pathogenesis and persistence commonly seen with invasive methicillin-resistant S. aureus and may be attributed to the combination of resistance genes (SCCmec type IV), putative virulence factors (arcA and opp3a), cytolytic peptide production (α-type phenol-soluble modulins), and biofilm adhesion, interaction, and maturation (bhp, aap, and β-type phenol-soluble modulins).

  20. Gene : CBRC-HSAP-19-0100 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available iens] dbj|BAA95414.1| G protein-coupled receptor C5L2 [Homo sapiens] gb|AAP23197.1| C5A anap...23872 /ug=Hs.534412 /len=1287 0.0 100% C5a-des-Arg anaphylatoxin Gi/o,Gq/11 MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAP...CBRC-HSAP-19-0100 19 A Chemokines and chemotactic factors receptors C5ARL_HUMAN 0.0... 100% ref|NP_060955.1| G protein-coupled receptor 77 [Homo sapiens] sp|Q9P296|C5ARL_HUMAN C5a anaphylatoxin ...chemotactic receptor C5L2 (G-protein coupled receptor 77) gb|AAK12640.1|AF317655_1 G protein-coupled receptor [Homo sap

  1. Gene : CBRC-HSAP-14-0064 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available iens] emb|CAA60109.1| B2-bradykinin receptor gene [Homo sapiens] gb|AAP...CBRC-HSAP-14-0064 14 A Bradykinin receptors NONE BKRB2_HUMAN 0.0 100% ref|NP_000614....1| bradykinin receptor B2 [Homo sapiens] sp|P30411|BKRB2_HUMAN B2 bradykinin receptor (BK-2 receptor) (B2R)... gb|AAK56376.1|AF378542_1 bradykinin receptor B2 [Homo sapiens] emb|CAA60108.1| B-2 bradykinin receptor gene [Homo sap...32297.1| bradykinin receptor B2 [Homo sapiens] gb|AAH74895.1| Bradykinin receptor B2 [Homo sapiens] gb|AAH74

  2. DOI发展现状及其在学术出版中的意义

    Institute of Scientific and Technical Information of China (English)

    杨小平

    2008-01-01

    @@ 1 DOI简介 DOI(Digital Object Identifier),数字对象唯一标志符.DOI系统是美国出版商协会(AmericanAssociate of Publishing,AAP)1994年成立的非赢利性组织国际DOI基金会(International DOI Fun-dation,IDF)在美国国家创新研究组织(The Cor-poration for National Research Institute,CNRI)的配合下,专门研究设计出来的一种既能保护知识产权又能保障版权所有者商业利益的系统[1].

  3. DOI简介

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>DOI(Digital Object Identifier),即文献数字对象识别号,为美国出版商协会(The Association of American Publishers,AAP)于1994年建立,1997年成为数字资源命名的一项标准。DOI能让学术文章永久寻址,实现文献永续存在。《厦门大学法律评论》从2013年起,通过台湾元照出版公司提供的平台,正式加入DOI系统,所有本刊刊发的文章将正式获得全球唯一且永续的"身份证号"。

  4. DOI简介

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    <正>DOI(Digital Object Identifier),即文献数字对象识别号,为美国出版商协会(The Association of American Publishers,AAP)于1994年建立;1997年成为数字资源命名的一项标准。DOI能让学术文章永久寻址,实现文献永续存在。《厦门大学法律评论》从2013年起,通过台湾元照出版公司提供的平台,正式加入DOI系统,所有本刊刊发的文章将正式获得全球唯一且永续的"身份证号"。

  5. Virulence factors profiles and ESBL production in Escherichia coli causing bacteremia in Peruvian children.

    Science.gov (United States)

    Palma, Noemí; Gomes, Cláudia; Riveros, Maribel; García, Wilfredo; Martínez-Puchol, Sandra; Ruiz-Roldán, Lidia; Mateu, Judit; García, Coralith; Jacobs, Jan; Ochoa, Theresa J; Ruiz, Joaquim

    2016-09-01

    The presence of 25 virulence genes (VGs), genetic phylogroups, quinolone-resistance and Extended Spectrum β-lactamase (ESBL)-production was assessed in 65 Escherichia coli isolates from blood cultures in children Quinolone-susceptible (22 isolates - 33.8%) and ESBL-negative (31 isolates - 47.7%) isolates carried more VGs that their respective counterparts (5.7 vs. 4.7 and 5.3 vs. 4.4 respectively); the frequency of the fyuA, aat, aap, and hly genes significantly differed between quinolone-resistant and quinolone-susceptible isolates. Neonatal sepsis isolates tended to be more quinolone-resistant (P = 0.0697) and ESBL-producers (P = 0.0776). Early-onset neonatal sepsis isolates possessed a high number of VGs (5.2 VGs), especially in neonates of ≤1 day (5.9 VGs). PMID:27345125

  6. Newborn care and safety: the black box of obstetric practices and residency training.

    Science.gov (United States)

    Tracy, Erin E; Haas, Susan; Lauria, Michele R

    2012-09-01

    Certain causes of newborn mortality such as sudden unexpected infant death, which includes sleep-related infant death and sudden unexplained infant death syndrome, are potentially preventable. Obstetricians are uniquely positioned to counsel new parents about safe practices regarding newborn sleep, feeding, and transportation. Patients often do not develop a relationship with their pediatricians until the neonate has been discharged, and the newborn period is a time of particular vulnerability. Newborn safety should be routinely taught in obstetric curricula, and the American College/Congress of Obstetricians and Gynecologists and the American Academy of Pediatrics (AAP) should partner to disseminate updated literature and guidelines to health care providers regarding newborn safety. Current guidelines from the Academy of Pediatrics Task Force on Sudden Infant Syndrome are summarized in this article. PMID:22914475

  7. Analysis of Surface Roughness at Overlapping Laser Shock Peening

    Science.gov (United States)

    Dai, F. Z.; Zhang, Z. D.; Zhou, J. Z.; Lu, J. Z.; Zhang, Y. K.

    2016-02-01

    The overlapping effects on surface roughness are studied when samples are treated by laser shock peening (LSP). Surface roughness of overlapped circular laser spot is calculated by ISO 25178 height parameters. The usually used overlapping styles namely isosceles-right-triangle-style (AAP) and equilateral-triangle-style (AAA) are carefully investigated when the overlapping degree in x-axis (ηx) is below 50%. Surface roughness of isosceles-right-triangle-style attains its minimum value at ηx of 29.3%, and attains its maximum value at ηx of 43.6%. Surface roughness of equilateral-triangle-style attains its minimum value at ηx of 42.3%, and attains its maximum value at ηx of 32%. Experimental results are well consistent with theoretical analysis.

  8. Gene : CBRC-HSAP-12-0004 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available 100% ref|NP_004045.1| complement component 3a receptor 1 [Homo sapiens] sp|Q16581|C3AR_HUMAN C3a anaphylatox...in chemotactic receptor (C3a-R) (C3AR) emb|CAA97504.1| C3a anaphylatoxin receptor [Homo sapiens] gb|AAH20742....1| Complement component 3a receptor 1 [Homo sapiens] dbj|BAC06088.1| seven trans...membrane helix receptor [Homo sapiens] gb|AAP23198.1| complement component 3a receptor 1 [Homo sapiens] gb|A...AR13862.1| complement component 3a receptor 1 [Homo sapiens] gb|EAW88640.1| complement component 3a receptor

  9. NCBI nr-aa BLAST: CBRC-OSAT-07-0001 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OSAT-07-0001 ref|NP_001064403.1| Os10g0348600 [Oryza sativa (japonica cultivar...-group)] gb|AAM74420.1|AC123594_3 Hypothetical protein [Oryza sativa (japonica cultivar-group)] gb|AAN05362....1| Unknown protein [Oryza sativa (japonica cultivar-group)] gb|AAP53188.1| expressed protein [Oryza sativa (japonica cultiva...r-group)] dbj|BAF26317.1| Os10g0348600 [Oryza sativa (japonica cultiva...r-group)] gb|EAZ15766.1| hypothetical protein OsJ_029975 [Oryza sativa (japonica cultivar-group)] NP_001064403.1 0.0 61% ...

  10. 印度把握“极端之地”的未来——ZeeTV:营销“印度象”的王牌

    Institute of Scientific and Technical Information of China (English)

    刘嘉偌; 高远(摄影)

    2007-01-01

    著名电视人拉杰特-沙马认为,类似于AapKiAdalat(电视政论节目)这样的高质量节目,以及通过技术把精彩娱乐带到消费者面前,可谓Zee电视台成功的两大至要。他还坚持,这家电视台不仅是商业意义上的成功,也直接推动了印度的改革开放,“让印度人民了解了外部世界,也让世界了解印度。某种程度上,可以说是营销印度的先锋。”

  11. Gene : CBRC-MMUS-17-0163 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-17-0163 17 A Odorant/olfactory and gustatory receptors OR2BB_HUMAN 1e-101... 57% ref|NP_667042.1| olfactory receptor 133 [Mus musculus] gb|AAL60925.1| olfactory receptor MOR256-6 [Mus musculus...] gb|AAP71256.1| olfactory receptor Olfr133 [Mus musculus] gb|AAQ77061.1| olfactory receptor 133 [Mus musculus...] gb|AAI32058.1| Olfactory receptor 133 [Mus musculus] gb|AAI32060.1| O...lfactory receptor 133 [Mus musculus] gb|EDL23374.1| mCG64027 [Mus musculus] 1e-179 100% gnl|UG|Mm#S36660534 Mus musculus

  12. Gene : CBRC-MMUS-02-0321 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0321 2 A Odorant/olfactory and gustatory receptors OR4B1_HUMAN 1e-145 ...82% ref|NP_667196.1| olfactory receptor 1270 [Mus musculus] gb|AAL60766.1| olfactory receptor MOR227-1 [Mus musculus...] gb|AAP71663.1| olfactory receptor Olfr1270 [Mus musculus] gb|AAI19114.1| Olfactory receptor 1270 [Mus musculus...] gb|AAI19116.1| Olfactory receptor 1270 [Mus musculus] emb|CAM17969....1| olfactory receptor 1270 [Mus musculus] gb|EDL27478.1| olfactory receptor 1270 [Mus musculus] 1e-170 100% gnl|UG|Mm#S34327486 Mus

  13. Gene : CBRC-MMUS-09-0177 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-09-0177 9 A Odorant/olfactory and gustatory receptors OR6X1_HUMAN 1e-153 ...85% ref|NP_666826.1| olfactory receptor 986 [Mus musculus] gb|AAL61145.1| olfactory receptor MOR104-3 [Mus musculus...] gb|AAP71447.1| olfactory receptor Olfr986 [Mus musculus] gb|AAI16769.1| Olfactory receptor 986 [Mus musculus...] gb|AAI16771.1| Olfactory receptor 986 [Mus musculus] 1e-176 100% gnl|UG|Mm#S33850932 Mus mus...culus olfactory receptor 986, mRNA (cDNA clone MGC:151147 IMAGE:40126089), complete cd

  14. Gene : CBRC-MMUS-02-0365 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0365 2 A Odorant/olfactory and gustatory receptors OR4KE_HUMAN 1e-104 ...59% ref|NP_667098.1| olfactory receptor 1301 [Mus musculus] gb|AAL60864.1| olfactory receptor MOR248-5 [Mus musculus...] gb|AAP71692.1| olfactory receptor Olfr1301 [Mus musculus] emb|CAM27187.1| olfactory receptor 1301 [Mus musculus...] gb|EDL27820.1| olfactory receptor 1301 [Mus musculus] 1e-177 100% gnl|UG|Mm#S9745172 Mus... musculus olfactory receptor 1301 (Olfr1301), mRNA /cds=p(1,939) /gb=NM_146887 /gi=221

  15. Gene : CBRC-MMUS-04-0019 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-04-0019 4 A Odorant/olfactory and gustatory receptors O13J1_HUMAN 1e-145 ...82% ref|NP_062359.1| olfactory receptor 71 [Mus musculus] emb|CAB55597.1| olfactory receptor [Mus musculus] ...emb|CAB96152.1| olfactory receptor [Mus musculus] gb|AAL60904.1| olfactory receptor MOR262-4 [Mus musculus] ...gb|AAP70821.1| olfactory receptor Olfr71 [Mus musculus] emb|CAM17056.1| olfactory receptor 71 [Mus mus...culus] gb|AAI41883.1| Olfactory receptor 71 [Mus musculus] gb|AAI41893.1| Olfactory receptor 71 [Mus musculus

  16. Gene : CBRC-MMUS-11-0013 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-11-0013 11 A Odorant/olfactory and gustatory receptors O2T27_HUMAN 1e-110... 60% ref|NP_667088.1| olfactory receptor 1395 [Mus musculus] gb|AAL60876.1| olfactory receptor MOR277-1 [Mus musculus...] gb|AAP71777.1| olfactory receptor Olfr1395 [Mus musculus] emb|CAM46261.1| olfactory receptor 1395 [Mus musculus...] gb|EDL33774.1| olfactory receptor 1395 [Mus musculus] 1e-180 100% gnl|UG|Mm#S9745164 Mus... musculus olfactory receptor 1395 (Olfr1395), mRNA /cds=p(1,954) /gb=NM_146877 /gi=22

  17. Determination of tryptophan and tryptophan metabolites in grape must and wine.

    Science.gov (United States)

    Hoenicke, K; Simat, T J; Steinhart, H; Christoph, N; Köhler, H J; Schwab, A

    1999-01-01

    Tryptophan (Trp) and its metabolites, especially indole-3-acetic acid (IAA), are considered as potential precursors of 2-aminoacetophenone (AAP), an aroma compound which causes the "untypical aging off-flavor" (UTA) in Vitis vinifera white wines. In this study RP-HPLC with fluorescence detection was used for the qualitative and quantitative analysis of Trp and Trp-metabolites in 39 grapes, 22 grape musts and 16 wines, to which different viticultural conditions (ripeness, pruning, strip of leaves, soil condition) have been applied. A sensitive and selective determination was achieved after solid phase extraction using an anion exchange material. Only traces of Trp-metabolites could be determined in the examined grapes and grape musts, but their amounts increased significantly during fermentation, whereas the amount of Trp decreased. Different viticultural measures, besides the time of grape harvest, showed no significant influences on the amount of Trp and Trp-metabolites.

  18. NCBI nr-aa BLAST: CBRC-PVAM-01-0526 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PVAM-01-0526 ref|NP_000904.1| opiate receptor-like 1 [Homo sapiens] ref|NP_872588.1| opiate...gb|AAA84913.1| orphan opioid receptor [Homo sapiens] gb|AAH38433.1| OPRL1 protein [Homo sapiens] gb|AAP23195.1| opiate... receptor-like 1 [Homo sapiens] emb|CAG46858.1| OPRL1 [Homo sapiens] emb|CAD11904.2| opiate recept...or-like 1 [Homo sapiens] emb|CAC17003.2| opiate receptor-like 1 [Homo sapiens] gb|ABM84132.1| opiate... receptor-like 1 [synthetic construct] gb|ABM84133.1| opiate receptor-like 1 [synthetic c

  19. NCBI nr-aa BLAST: CBRC-HSAP-20-0024 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-HSAP-20-0024 ref|NP_000904.1| opiate receptor-like 1 [Homo sapiens] ref|NP_872588.1| opiate...OPRL1 protein [Homo sapiens] gb|AAP23195.1| opiate receptor-like 1 [Homo sapiens] emb|CAG46858.1| OPRL1 [Hom...o sapiens] emb|CAD11904.2| opiate receptor-like 1 [Homo sapiens] emb|CAC17003.2| opiate receptor-like 1 [Hom...o sapiens] gb|ABM84132.1| opiate receptor-like 1 [synthetic construct] gb|ABM84133.1| opiate... receptor-like 1 [synthetic construct] gb|ABW03593.1| opiate receptor-like 1 [synthetic construct] NP_000904.1 0.0 100% ...

  20. NCBI nr-aa BLAST: CBRC-CFAM-24-0010 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CFAM-24-0010 ref|NP_000904.1| opiate receptor-like 1 [Homo sapiens] ref|NP_872588.1| opiate...OPRL1 protein [Homo sapiens] gb|AAP23195.1| opiate receptor-like 1 [Homo sapiens] emb|CAG46858.1| OPRL1 [Hom...o sapiens] emb|CAD11904.2| opiate receptor-like 1 [Homo sapiens] emb|CAC17003.2| opiate receptor-like 1 [Hom...o sapiens] gb|ABM84132.1| opiate receptor-like 1 [synthetic construct] gb|ABM84133.1| opiate... receptor-like 1 [synthetic construct] gb|ABW03593.1| opiate receptor-like 1 [synthetic construct] NP_000904.1 0.0 96% ...