WorldWideScience

Sample records for aaps

  1. Role for the A domain of unprocessed accumulation-associated protein (Aap) in the attachment phase of the Staphylococcus epidermidis biofilm phenotype.

    Science.gov (United States)

    Conlon, Brian P; Geoghegan, Joan A; Waters, Elaine M; McCarthy, Hannah; Rowe, Sarah E; Davies, Julia R; Schaeffer, Carolyn R; Foster, Timothy J; Fey, Paul D; O'Gara, James P

    2014-12-01

    The polysaccharide intercellular adhesin or the cell wall-anchored accumulation-associated protein (Aap) mediates cellular accumulation during Staphylococcus epidermidis biofilm maturation. Mutation of sortase, which anchors up to 11 proteins (including Aap) to the cell wall, blocked biofilm development by the cerebrospinal fluid isolate CSF41498. Aap was implicated in this phenotype when Western blots and two-dimensional (2D) electrophoresis revealed increased levels of the protein in culture supernatants. Unexpectedly, reduced levels of primary attachment were associated with impaired biofilm formation by CSF41498 srtA and aap mutants. In contrast to previous studies, which implicated Aap proteolytic cleavage and, specifically, the Aap B domains in biofilm accumulation, the CSF41498 Aap protein was unprocessed. Furthermore, aap appeared to play a less important role in the biofilm phenotype of S. epidermidis 1457, in which the Aap protein is processed. Anti-Aap A-domain IgG inhibited primary attachment and biofilm formation in strain CSF41498 but not in strain 1457. The nucleotide sequences of the aap gene A-domain region and cleavage site in strains CSF41498 and 1457 were identical, implicating altered protease activity in the differential Aap processing results in the two strains. These data reveal a new role for the A domain of unprocessed Aap in the attachment phase of biofilm formation and suggest that extracellular protease activity can influence whether Aap contributes to the attachment or accumulation phases of the S. epidermidis biofilm phenotype.

  2. Spectroscopic Classification of SN 2017aap as a Type Ia Supernova

    Science.gov (United States)

    Zhang, Jujia; Xin, Yuxin; Xu, Zhijian; Li, Wenxiong; Wang, Xiaofeng; Li, Bin; Zhao, Haibin; Wang, Lifan; Tan, Hanjie; Rui, Liming; Yang, Zesheng

    2017-02-01

    We obtained an optical spectrum (range 340-830 nm) of SN 2017aap (=PTSS-17die), discovered by the PMO-Tsinghua Supernova Survey (PTSS, http://www.cneost.org/ptss/), on UT Feb.02.9 2017 with the 2.4 m telescope (LJT + YFOSC) at LiJiang Gaomeigu Observatory of Yunnan Observatories (YNAO).

  3. Scientific impact of presentations from the EURAPS and the AAPS meetings

    DEFF Research Database (Denmark)

    Khorasani, Hoda; Lassen, Mats Højbjerg; Kuzon, William

    2017-01-01

    INTRODUCTION: Presentation at scientific meetings is the usual first step to communicate new research findings. However, without subsequent, peer-reviewed publication, the wider propagation and the permanent documentation of important scholarly work may be lost. Our aim was to analyze and compare...... the publication status of the work presented at the European Association of Plastic Surgeons' (EURAPS) and at the American Association of Plastic Surgeons' (AAPS) annual meetings. MATERIALS AND METHODS: By using the abstract booklets from the annual meetings, all presentations given over a 10-year period (2000...... and EURAPS have the highest publication rates for surgical abstracts, indicating a high scientific value of these meetings....

  4. Co-metabolic biodegradation of acetamiprid by Pseudoxanthomonas sp. AAP-7 isolated from a long-term acetamiprid-polluted soil.

    Science.gov (United States)

    Wang, Guangli; Zhao, Yanjiao; Gao, Hao; Yue, Wenlong; Xiong, Minghua; Li, Feng; Zhang, Hui; Ge, Wei

    2013-12-01

    An AAP-degrading bacterium, AAP-7, was isolated from AAP-polluted soil. AAP-7 was identified as Pseudoxanthomonas sp. on the basis of the comparative analysis of 16S rDNA sequences. The strain was able to transformate more than 80% AAP by means of co-metabolism and degraded AAP via hydrolysis or demethylation to form (E)-3-(((6-chloropyridin-3yl)methyl)(methyl)amino)acrylonitrile and N-((6-chloropyridin-3yl)methyl)-N-methylprop-1-en-2-amine, both of which transformed into ultimate product, which was 1-(6-chloropyridin-3yl)-N-methylmethanamine. A novel degradation pathway was proposed based on these metabolites. AAP could be transformed with a maximum specific degradation rate, half-saturation constant and inhibit constant of 1.775/36 h, 175.3 mg L(-1), and 396.5 mg L(-1), respectively, which proved that the degradation rate of AAP could be restrained at high AAP concentration. This paper highlights a significant potential use of co-metabolic cultures of microbial cells for the cleanup of AAP-contaminated soil.

  5. SELECTIVE EVALUATION OF TWO URINARY ENZYMES (NAG AND AAP BEFORE AND AFTER UNILATERAL SHOCK WAVE LITHOTRIPSY

    Directory of Open Access Journals (Sweden)

    M. R. Nikoobakht

    2006-09-01

    Full Text Available Biological effects extracorporeal shock wave lithotripsy (ESWL is not precisely known. We have evaluated two urinary enzymes activity N-acetyl-B-D-glucosamine (NAG and alanine amino peptidase (AAP before and after unilateral ESWL as markers for renal parenchymal damage. Forty eight patients with kidney stones (mean age 39 who had presented for the first time or at least one year after their previous lithotripsy underwent ESWL. Urinary specimens were collected before and after first, third and seventh days of lithotripsy and NAG, AAP were evaluated. These enzymes displayed the greatest activity 24 hours after ESWL with significant difference compared to the control group, (P < 0.05 versus 0.02. Elevation of urinary enzymes activity correlated with stone size particularly stones larger than 2 cm. These data suggest that there is some tubular and parenchymal damage induced by ESWL that needs time to get improved. The higher urinary enzyme activity in patients with larger stones ( > 2 cm is probably related to injury resulting from passage of smaller stones, produced after lithotripsy of a large stone, and it is suggested that these patients are treated with a safer procedure.

  6. Autolytic Activity and Plasma Binding Study of Aap, a Novel Minor Autolysin of Streptococcus pneumoniae

    Directory of Open Access Journals (Sweden)

    Ramina Mahboobi

    2016-04-01

    Full Text Available Pneumococcal autolysins are enzymes involved in cell wall turnover and cellular division physiologically. They have been found to be involved in the pneumococcus pathogenesis. The aim of this study was to identify the autolytic activity of Spr1754 as a novel protein of Streptococcus pneumoniae. Moreover, the binding of the recombinant protein to plasma proteins was also determined. The spr1754 gene was amplified by PCR and cloned into the pET21a(+ prokaryotic expression vector. The constructed pET21a(+/spr1754 recombinant plasmid was transformed into E. coli Origami (DE3 and induced using IPTG. The recombinant protein of Spr1754 was purified by Ni-NTA affinity chromatography and confirmed by SDS-PAGE and Western blot analysis using anti-His tag monoclonal antibody. Autolytic activity and the ability of the recombinant protein in binding to plasma proteins were performed using zymogram analysis and western blot, respectively. The spr1754 with expected size was cloned and overexpressed in Escherichia coli Origami (DE3, successfully. After purification of the Spr1754 recombinant protein, the autolytic activity was observed by zymography. Of the four plasma proteins used in this study, binding of lactoferrin to Spr1754 recombinant protein was shown. The Spr1754 recombinant protein has a bifunctional activity, i.e., as being autolysin and lactoferrin binding and designated as Aap (autolytic/ adhesion/ pneumococcus. Nevertheless, characterization of the Aap needs to be followed using gene inactivation and cell wall localization.

  7. Newborn Male Circumcision with Parental Consent, as Stated in the AAP Circumcision Policy Statement, Is Both Legal and Ethical.

    Science.gov (United States)

    Brady, Michael T

    2016-06-01

    Newborn male circumcision is a minor surgical procedure that has generated significant controversy. Accumulating evidence supports significant health benefits, most notably reductions in urinary tract infections, acquisition of HIV and a number of other sexually transmitted infections, penile cancer, phimosis, paraphimosis, balanitis and lichen sclerosis. While circumcision, like any surgical procedure, has risks for complications, they occur in less than 1 in 500 infants circumcised and most are minor and require minimal intervention. The CDC and the American Academy of Pediatrics (AAP) believe that health benefits of circumcision outweigh the risks. For this reason, the AAP believes that parents should be allowed to make the decision concerning circumcision of their male infants after receiving non-biased information on health risks and health benefits.

  8. [Neonatal hypoxic-ischemic nephropathy and urinary diagnostic indices: the utility of measuring tubular enzymes (NAG and AAP)].

    Science.gov (United States)

    Bertotti, A; De Marchi, S; Brovedani, P; Gaeta, G; Peratoner, L; Mangiarotti, M A

    1990-01-01

    Feto-neonatal hypoxia can cause a functional kidney impairment, which is often temporary and not clinically overt, but sometimes leading to acute renal failure. Hypoxic stress may result in a tubulo-interstitial damage, and kidney tubular enzymes determination has proved to be an easy, early, and non invasive method to define a tubular interstitial lesion. A major target of nephrotoxicity is the proximal tubular cell: alterations in brush-border membrane and cytoplasm result in increased turnover processes in the kidney cortex, following by a corresponding increased excretion of alanine-aminopeptidase (AAP) and N-acetyl-glucosaminidase (NAG) from the proximal tubular cells, long before glomerular or tubular functions are impaired. AAP and NAG excretion is directly correlated with the strength and the duration of toxic alteration of the proximal tubule. NAG and AAP have been already studied in the adults and the children; they have been chosen for this investigation with a double aim: 1) to define the amount of their urinary excretion in relation with gestational age at birth; 2) to evaluate if in the newborn, independently of the gestational age, their urinary concentration may be increased by ischaemic conditions caused by hypoxia. We studied 52 healthy newborns (7 preterm of 33-36 weeks and 45 full-term) and 16 newborns with feto-neonatal hypoxia (8 preterm of 26-36 weeks and full-term) at the forth day of life. Urinary NAG and AAP were assayed by colorimetric methods and the results expressed as mU/mg. creatininuria.(ABSTRACT TRUNCATED AT 250 WORDS)

  9. Role of the two-component regulatory system arlRS in ica operon and aap positive but non-biofilm-forming Staphylococcus epidermidis isolates from hospitalized patients.

    Science.gov (United States)

    Wu, Yang; Liu, Jingran; Jiang, Juan; Hu, Jian; Xu, Tao; Wang, Jiaxue; Qu, Di

    2014-11-01

    The ica operon and aap gene are important factors for Staphylococcus epidermidis biofilm formation. However, we found 15 out of 101 S. epidermidis strains isolated from patients had both the ica operon and the aap gene in the genome but could not form biofilms (ica(+)aap(+)/BF(-) isolates). Compared with standard strain RP62A, the 15 ica(+)aap(+)/BF(-) isolates had similar growth curves and initial attachment abilities, but had much lower apparent transcription levels of the icaA gene and significantly less production of polysaccharide intercellular adhesion (PIA). Furthermore, the expression of accumulation-associated protein in ica(+)aap(+)/BF(-) isolates was much weaker than in RP62A. The mRNA levels of icaADBC transcription-related regulatory genes, including icaR, sarA, rsbU, srrA, arlRS and luxS, were measured in the 15 ica(+)aap(+)/BF(-) clinical isolates. The mRNA levels of arlR and rsbU in all of the ica(+)aap(+)/BF(-) isolates were lower than in RP62A at 4 h. At 10 h, 14/15 of the isolates showed lower mRNA levels of arlR and rsbU than shown by RP62A. However, expression of sarA, luxS, srrA and icaR varied in different ica(+)aap(+)/BF(-) isolates. To further investigate the role of arlRS in biofilm formation, we analyzed icaA, sarA and rsbU transcription, PIA synthesis, Aap expression and biofilm formation in an arlRS deletion mutant of S. epidermidis strain 1457 and all were much less than in the wild type strain. This is consistent with the hypothesis that ArlRS may play an important role in regulating biofilm formation by the ica(+)aap(+)/BF(-)S. epidermidis clinical isolates and operate via both ica-dependent and Aap-dependent pathways.

  10. Veracity and rhetoric in paediatric medicine: a critique of Svoboda and Van Howe's response to the AAP policy on infant male circumcision.

    Science.gov (United States)

    Morris, Brian J; Tobian, Aaron A R; Hankins, Catherine A; Klausner, Jeffrey D; Banerjee, Joya; Bailis, Stefan A; Moses, Stephen; Wiswell, Thomas E

    2014-07-01

    In a recent issue of the Journal of Medical Ethics,Svoboda and Van Howe commented on the 2012 changein the American Academy of Pediatrics (AAP) policy on newborn male circumcision, in which the AAP stated that benefits of the procedure outweigh the risks. Svoboda and Van Howe disagree with the AAP conclusions. We show here that their arguments against male circumcision are based on a poor understanding of epidemiology,erroneous interpretation of the evidence, selective citation of the literature, statistical manipulation of data, and circular reasoning. In reality, the scientific evidence indicates that male circumcision, especially when performed in the newborn period, is an ethically and medically sound low-risk preventive health procedure conferring a lifetime of benefits to health and well-being.Policies in support of parent-approved elective newborn circumcision should be embraced by the medical,scientific and wider communities.

  11. Distribution of Pathogenic Genes aatA, aap, aggR, among Uropathogenic Escherichia coli (UPEC) and Their Linkage with StbA Gene.

    Science.gov (United States)

    Nazemi, A; Mirinargasi, M; Merikhi, N; Sharifi, S H

    2011-07-01

    Urinary tract infection (UTI) with E. coli (UPEC) is one of the most common bacterial infections among human beings. In addition to the host predisposing factors, genes are also proposed to have an important role in the occurrence of UTIs. This study investigated the distribution of three pathogenic genes including aggR, aap and aatA among UPEC infected samples and their linkage with stbA, the essential gene for maintaining of pAA plasmid. A total of 244 samples were collected from patients with UTIs through clinical laboratories located in western side of Tehran (Iran) during years 2008-2009. E. coli isolation was performed according to standard laboratory methods. DNAs were extracted from samples using Boiling method, and the presence of aap, aggR, aatA and stbA genes were investigated by PCR. No pathogenic genes (aap, aggR, aatA) were found in 104 out of 244 UPEC samples, while 14 of them were carrying stbA gene. Out of 140 UPEC samples with pathogenic genes, 94 (46.6%) were carrying aap gene, 52 (23%) aggR gene, and 80 (35.4%) aatA gene. A total of 18 samples were also carrying all pathogenic genes together. Moreover, 44 out of 144 samples were carrying stbA gene. The results obtained by this study showed that the aggR, aap and aatA pathogenic genes have different existence patterns in different E. coli strains that infect different organs. Our study also showed that these three plasmid genes in EAEC strains are able to transpose in the genome and change their level of linkage with pAA plasmid essential gene stbA. Meanwhile, this study confirmed that aggR, aap and aatA genes are not specific to only EAEC strains.

  12. 2012 AAPS National Biotech Conference Open Forum: a perspective on the current state of immunogenicity prediction and risk management.

    Science.gov (United States)

    Rajadhyaksha, Manoj; Subramanyam, Meena; Rup, Bonnie

    2013-10-01

    The immunogenicity profile of a biotherapeutic is determined by multiple product-, process- or manufacturing-, patient- and treatment-related factors and the bioanalytical methodology used to monitor for immunogenicity. This creates a complex situation that limits direct correlation of individual factors to observed immunogenicity rates. Therefore, mechanistic understanding of how these factors individually or in concert could influence the overall incidence and clinical risk of immunogenicity is crucial to provide the best benefit/risk profile for a given biotherapeutic in a given indication and to inform risk mitigation strategies. Advances in the field of immunogenicity have included development of best practices for monitoring anti-drug antibody development, categorization of risk factors contributing to immunogenicity, development of predictive tools, and development of effective strategies for risk management and mitigation. Thus, the opportunity to ask "where we are now and where we would like to go from here?" was the main driver for organizing an Open Forum on Improving Immunogenicity Risk Prediction and Management, conducted at the 2012 American Association of Pharmaceutical Scientists' (AAPS) National Biotechnology Conference in San Diego. The main objectives of the Forum include the following: to understand the nature of immunogenicity risk factors, to identify analytical tools used and animal models and management strategies needed to improve their predictive value, and finally to identify collaboration opportunities to improve the reliability of risk prediction, mitigation, and management. This meeting report provides the Forum participant's and author's perspectives on the barriers to advancing this field and recommendations for overcoming these barriers through collaborative efforts.

  13. Economic evaluation of carbon adsorption/ion exchange wastewater-treatment options for Sunflower AAP (Army Ammunition Plant) NQ (nitroguanidine) wastewater-treatment facility. Final report, October 1986-July 1987

    Energy Technology Data Exchange (ETDEWEB)

    Balasco, A.A.; Cheng, G.C.; Field, E.L.; Vejins, V.R.

    1987-07-31

    The objective of this subtask was to provide an estimate of the capital investment and operating costs for the wastewater-treatment technology option involving activated-carbon adsorption and ion exchange for primary separation, and multiple-effect evaporation and spray drying for volume reduction. During the course of this study, however, it became evident that the process economics could be significantly improved of the ion-exchange step was eliminated from the process scheme. The bases for the system design, plant operation, and cost evaluation were provided to Arthur D. Little by Sunflower AAP personnel to make certain that direct comparisons could be made with other treatment options under consideration.

  14. DTPA Inhibits Formation of Staphylococcus Epidermidis Biofilm Associated with Prosthetic Joints: Relative Gene (AAP) Expressions%Zn2+螯合剂DTPA(二乙基三胺五乙酸)对人工关节假体感染后表皮葡萄球菌生物膜形成及相关基因表达的影响

    Institute of Scientific and Technical Information of China (English)

    薛俊强; 戚超; 王湘达; 申友亮; 于腾波

    2012-01-01

    Objective:To investigate theinhibitory effect of DTPA on the formation of Staphylococcus epidertnidis biofilm and the expressions of relative genes(AAP).Methods:New Zealand white rabbits were used to establish the animal model of prosthetic joints infection.Rabbits were randomly divided into the experimental group and control group.The bacteria were injected with 0.1ml 1% DTPA into the knee of rabbits in experimental group; The rabbits were injected with bacteria in the control group.Synovial fluid was extracted in the 2,4,6,8 and 16 days.The expressions of AAP were detected by the way of fluorescent quantitation RT-PCR,Scanning electron microscopy and histological observations were dettected.Results:DTPA can significantly inhibit the expression of AAP in Staphylococcus epidermidis.Scanning electron microscopy found on the day of 2,4,6,8,16 the number of bacteria adhere to the prosthetic surface had decreased significantly in experimental group compared with that in the control group.Conclusion:DTPA can inhibit the formation of the biofilm of Staphylococcus epidermidisthrough suppressing the relative genes.%目的:探讨DTPA对人工关节假体(prosthetic joints infection,PJI)感染后表皮葡萄球茵生物膜形成及所需基因聚集相关蛋白(AAP)基因表达的影响.方法:构建新西兰大白兔假体感染表皮葡萄球菌生物膜模型,随机分为实验组(n=25)和对照组(n=25),对照组只注射细茵,实验组在注入细菌的同时,注射DTPA,分别于注射后第2、4、6、8、16天灌洗、收集膝关节液,采用RT-PCR方法检测不同时间点目的基因AAP基因表达的变化.对不同时间点的假体感染动物行膝关节假体扫描电镜和假体周围组织学观察.结果:DTPA可以显著抑制AAP基因的表达,扫描电镜观察第2、4、6、8、16天实验组较对照组假体表面粘附表皮葡萄球茵明显减少(P<0.05),生物膜明显受抑制.实验组假体周围组织炎性反应较对照组明显减轻.

  15. The Possibility of Building Nuclear Power Plant Free from Severe Accident Risk PWR NPP with advanced all passive safety cooling systems (AAP SCS)%发展无严重事故风险核电站的曙光具有完全非能动安全冷却系统的压水堆核电站

    Institute of Scientific and Technical Information of China (English)

    肖宏才

    2013-01-01

    A complete set of advanced all passive safety cooling systems (AAP SCS) for PWR NPP,actuated by natural force has been put forward in the article.Here the natural force mainly means the fore,which created by change of pressure distribution in the first loop of PWR as a result of operational regime conversion from one to another,including occurrence of accident situation.Correspondent safety cooling system will be actuated naturally and then put it into passive operation after occurring some kind of accident,so accidental situation will be mitigated right after it's occurrence and core residual heat will be naturally moved from the active core to the ultimate heat sink.There is no need to rely on automatic control system,any active equipment and human actions in all working process of the AAP SCS,which can reduce the probability of severe accident to zero,so as to exclude the need of evacuation plan around AAP nuclear power plant and eliminate the public's concern and doubt about nuclear power safety.Implementation of the AAP SCS concept is only based on use of evolutionary measures and state-of-the-art technology.So at present time it can be used for design of new-type third generation PWR nuclear power plant without severe accident risk,and for modernization of existing second generation nuclear power plant.%本文提出了用自然力直接触发启动压水堆核电站一整套完全非能动的停堆安全冷却系统.这里的自然力主要是指一回路运行工况转换时由于其压力分布变化所形成的压差力.在这一系统中,当进行停堆或发生某种一回路事故工况时,相应的安全冷却系统便自然地投入运行,立即缓解事故后果,将事故时一回路释放的能量及堆芯余热非能动地排入最终热阱.在全过程中不依靠自动控制系统、能动设备及任何人为因素的介入,即可确保对堆芯余热无限期的安全冷却能力,完全避免压水堆核电站发生向环境泄漏放射性物

  16. Out of step: fatal flaws in the latest AAP policy report on neonatal circumcision.

    Science.gov (United States)

    Svoboda, J Steven; Van Howe, Robert S

    2013-07-01

    The American Academy of Pediatrics recently released a policy statement and technical report on circumcision, in both of which the organisation suggests that the health benefits conferred by the surgical removal of the foreskin in infancy definitively outweigh the risks and complications associated with the procedure. While these new documents do not positively recommend neonatal circumcision, they do paradoxically conclude that its purported benefits 'justify access to this procedure for families who choose it,' claiming that whenever and for whatever reason it is performed, it should be covered by government health insurance. The policy statement and technical report suffer from several troubling deficiencies, ultimately undermining their credibility. These deficiencies include the exclusion of important topics and discussions, an incomplete and apparently partisan excursion through the medical literature, improper analysis of the available information, poorly documented and often inaccurate presentation of relevant findings, and conclusions that are not supported by the evidence given.

  17. Cultural bias in the AAP's 2012 Technical Report and Policy Statement on male circumcision

    NARCIS (Netherlands)

    Frisch, M.; Aigrain, Y.; Barauskas, V.; Bjarnason, R.; Boddy, S.A.; Czauderna, P.; Gier, R.P.E. de; Jong, T.P. de; Fasching, G.; Fetter, W.; Gahr, M.; Graugaard, C.; Greisen, G.; Gunnarsdottir, A.; Hartmann, W.; Havranek, P.; Hitchcock, R.; Huddart, S.; Janson, S.; Jaszczak, P.; Kupferschmid, C.; Lahdes-Vasama, T.; Lindahl, H.; Macdonald, N.; Markestad, T.; Martson, M.; Nordhov, S.M.; Palve, H.; Petersons, A.; Quinn, F.; Qvist, N.; Rosmundsson, T.; Saxen, H.; Soder, O.; Stehr, M.; Loewenich, V.C. von; Wallander, J.; Wijnen, R.

    2013-01-01

    The American Academy of Pediatrics recently released its new Technical Report and Policy Statement on male circumcision, concluding that current evidence indicates that the health benefits of newborn male circumcision outweigh the risks. The technical report is based on the scrutiny of a large numbe

  18. Aap, Noot, Mustafa...: Het effect van taalafstand en koloniaal verleden op leesprestaties

    NARCIS (Netherlands)

    Kooistra, J.P.; Ultee, W.C.; Pelzer, B.J.

    2008-01-01

    This study examines the effect of the distance between origin language and destination language on the reading skills of immigrant students, by building upon insights on the development of world languages, obtained from human population genetics. Lower-level research units are 1759 first-generation

  19. Aap, Noot, Mustafa… : Het effect van taalafstand en koloniaal verleden op leesprestaties

    NARCIS (Netherlands)

    Kooistra, Jan-Paul; Ultee, Wout; Pelzer, Ben

    2008-01-01

    Summary A is for apple, B is for Bushra: The influence of language distance and colonial experience on reading This study examines the effect of the distance between origin language and destination language on the reading skills of immigrant students, by building upon insights on the development of

  20. Cultural bias in the AAP's 2012 Technical Report and Policy Statement on male circumcision

    DEFF Research Database (Denmark)

    Frisch, Morten; Aigrain, Yves; Barauskas, Vidmantas

    2013-01-01

    in the United States seems obvious, and the report's conclusions are different from those reached by physicians in other parts of the Western world, including Europe, Canada, and Australia. In this commentary, a different view is presented by non-US-based physicians and representatives of general medical......The American Academy of Pediatrics recently released its new Technical Report and Policy Statement on male circumcision, concluding that current evidence indicates that the health benefits of newborn male circumcision outweigh the risks. The technical report is based on the scrutiny of a large...... urinary tract infections in infant boys, which can easily be treated with antibiotics without tissue loss. The other claimed health benefits, including protection against HIV/AIDS, genital herpes, genital warts, and penile cancer, are questionable, weak, and likely to have little public health relevance...

  1. AAPS-FDA workshop white paper : Microdialysis principles, application and regulatory perspectives

    NARCIS (Netherlands)

    Chaurasia, Chandra S.; Mueller, Markus; Bashaw, Edward D.; Benfeldt, Eva; Bolinder, Jan; Bullock, Ross; Bungay, Peter M.; DeLange, Elizabeth C. M.; Derendorf, Hartmut; Elmquist, William F.; Hammarlund-Udenaes, Margareta; Joukhadar, Christian; Kellogg, Dean L.; Lunte, Craig E.; Nordstrom, Carl Henrik; Rollema, Hans; Sawchuk, Ronald J.; Cheung, Belinda W. Y.; Shah, Vinod P.; Stahle, Lars; Ungerstedt, Urban; Welty, Devin F.; Yeo, Helen

    2007-01-01

    Many decisions in drug development and medical practice are based on measuring blood concentrations of endogenous and exogenous molecules. Yet most biochemical and pharmacological events take place in the tissues. Also, most drugs with few notable exceptions exert their effects not within the bloods

  2. NACO-SDI imaging of known companion host stars from the AAPS and Keck planet search surveys

    CERN Document Server

    Jenkins, J S; Biller, B; O'Toole, S J; Pinfield, D J; Close, L; Tinney, C G; Butler, R P; Wittenmyer, R; Carter, B; Day-Jones, A C

    2010-01-01

    Direct imaging of brown dwarfs as companions to solar-type stars can provide a wealth of well-constrained data to "benchmark" the physics of such objects, since quantities like metallicity and age can be determined from their well-studied primaries. We present results from an adaptive optics imaging program on stars drawn from the Anglo-Australian and Keck Planet Search projects, with the aim of directly imaging known cool companions. Simulations have modeled the expected contrast ratios and separations of known companions using estimates of orbital parameters available from current radial-velocity data and then a selection of the best case objects were followed-up with high contrast imaging to attempt to directly image these companions. These simulations suggest that only a very small number of radial-velocity detected exoplanets with consistent velocity fits and age estimates could potentially be directly imaged using the VLT's Simultaneous Differential Imaging system and only under favorable conditions. We...

  3. Onderzoek naar de mogelijke inductie van leuco-myelo-encephalopathie door inhalatoire blootstelling van een aap aan pyrolisaat van versneden heroine

    NARCIS (Netherlands)

    van der Laan JW; Timmerman A; Marra M; Wolters EC; Loeber JG; Dormans JAMA; Schipper MEI; Boot R

    1986-01-01

    Nadat vanaf 1980 enige tientallen personen het slachtoffer zijn geworden van een heroine-leuko-encephalopathie als gevolg van het "chinezen" van vnl. heroine zijn gedurende twee jaar geen slachtoffers gemeld. Twee slachtoffers in 1984, die bovendien een grote hoeveelheid heroine in het b

  4. Periodontitis and systemic diseases : a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases

    NARCIS (Netherlands)

    Linden, Gerry J; Herzberg, Mark C; van Winkelhoff, Arie

    2013-01-01

    BACKGROUND: There has been an explosion in research into possible associations between periodontitis and various systemic diseases and conditions. AIM: To review the evidence for associations between periodontitis and various systemic diseases and conditions, including chronic obstructive pulmonary

  5. Manufacturing Methods and Technology Project Summary Reports

    Science.gov (United States)

    1984-12-01

    laminate life ediction . This descending flow chart is an outline of composite material teractions under UV radiation, hydrothermal cycling, and mechanical... Milan AAP, ATTN: SMCMI-CO Cdr, Mississippi AAP, ATTN: SMCMS Cdr, Radford AAP, ATTN: SKCRA-CO Cdr, Riverbank AAP, ATTN: SMCRB-CO Cdr, Scranton AAP, ATTN

  6. Sports Injury Prevention Tip Sheet

    Science.gov (United States)

    ... Commemorative Giving Employment at AAP Advertise with AAP Advertising on AAP.org Advertising on AAP Journals & Publications AAP Mailing and eMail ... Help/Feedback a a a print email share Facebook Twitter 2017 Sports Injury Prevention Tip Sheet 3/ ...

  7. Iron Supplements Reduce Behavior Problems in Low Birth Weight Infants

    Science.gov (United States)

    ... Commemorative Giving Employment at AAP Advertise with AAP Advertising on AAP.org Advertising on AAP Journals & Publications AAP Mailing and eMail ... Help/Feedback a a a print email share Facebook Twitter Iron Supplements Reduce Behavior Problems in Low ...

  8. Protecting Children from Carbon Monoxide Poisoning

    Science.gov (United States)

    ... AAP Advertise with AAP Advertising on AAP.org Advertising on AAP Journals & Publications AAP Mailing and eMail List Corporate Relationships Conflict of Interest and Industry Relations Sponsorships Corporate Friends of Children Fund Corporate Relationship Guidelines Help/Feedback It looks ...

  9. Purification and characterization of novel cationic peroxidases from Asparagus acutifolius L. with biotechnological applications.

    Science.gov (United States)

    Guida, Vincenzo; Cantarella, Maria; Chambery, Angela; Mezzacapo, Maria C; Parente, Augusto; Landi, Nicola; Severino, Valeria; Di Maro, Antimo

    2014-08-01

    Four novel basic peroxidases, named AaP-1, AaP-2, AaP-3, and AaP-4, were purified from Asparagus acutifolius L. seeds by cation-exchange and gel filtration chromatographies. The four proteins showed a similar electrophoretic mobility of 46 kDa while, by MALDI-TOF MS, different Mr values of 42758.3, 41586.9, 42796.3, and 41595.5 were determined for AaP-1, AaP-2, AaP-3, and AaP-4, respectively. N-terminal sequences of AaPs 1-4 up to residue 20 showed a high percentage of identity with the peroxidase from Glycine max. In addition, AaP-1, AaP-2, AaP-3, and AaP-4 were found to be glycoproteins, containing 21.75, 22.27, 25.62, and 18.31 % of carbohydrates, respectively. Peptide mapping and MALDI-TOF MS analysis of AaPs 1-4 showed that the structural differences between AaP-1 and AaP-2 and AaP-3 and AaPs-4 were mainly due to their glycan content. We also demonstrate that AaPs were able to remove phenolic compounds from olive oil mill wastewaters with a higher catalytic efficiency with respect to horseradish peroxidase, thus representing candidate enzymes for potential biotechnological applications in the environmental field.

  10. NCBI nr-aa BLAST: CBRC-MMUS-08-0067 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-08-0067 gb|AAP03536.1| melanocortin 1 receptor [Chaetodipus intermedius] ...gb|AAP03538.1| melanocortin 1 receptor [Chaetodipus intermedius] gb|AAP03570.1| melanocortin 1 receptor [Chaetodipus intermedius...] gb|AAP03572.1| melanocortin 1 receptor [Chaetodipus intermedius] gb|AAP03590.1| melano...cortin 1 receptor [Chaetodipus intermedius] gb|AAP03592.1| melanocortin 1 receptor [Chaetodipus intermediu...s] gb|AAP03594.1| melanocortin 1 receptor [Chaetodipus intermedius] gb|AAP03596.1|

  11. American Academy of Pediatrics

    Science.gov (United States)

    ... and the diseases they prevent. Media and Children Communication Toolkit Tools to help pediatricians discuss with parents ... Donate Now Employment at AAP Advertise with AAP Corporate Relationships Help/Feedback Privacy Statement Contact Us Terms ...

  12. Gum Disease and Men

    Science.gov (United States)

    ... Recordings AAP Speakers List 2017 Annual Meeting Publications Journal of Periodontology JOP Online How to Subscribe Missing-Issue Claim Form Back-Issue Order Form JOP Editors Submit Manuscript Clinical Advances in Perio CAP Editors AAP Clinical and ...

  13. Gum Graft Surgery

    Science.gov (United States)

    ... Recordings AAP Speakers List 2017 Annual Meeting Publications Journal of Periodontology JOP Online How to Subscribe Missing-Issue Claim Form Back-Issue Order Form JOP Editors Submit Manuscript Clinical Advances in Perio CAP Editors AAP Clinical and ...

  14. Gum Disease Symptoms

    Science.gov (United States)

    ... Recordings AAP Speakers List 2017 Annual Meeting Publications Journal of Periodontology JOP Online How to Subscribe Missing-Issue Claim Form Back-Issue Order Form JOP Editors Submit Manuscript Clinical Advances in Perio CAP Editors AAP Clinical and ...

  15. Peri-Implant Diseases

    Science.gov (United States)

    ... Recordings AAP Speakers List 2017 Annual Meeting Publications Journal of Periodontology JOP Online How to Subscribe Missing-Issue Claim Form Back-Issue Order Form JOP Editors Submit Manuscript Clinical Advances in Perio CAP Editors AAP Clinical and ...

  16. Gum Disease and Women

    Science.gov (United States)

    ... Recordings AAP Speakers List 2017 Annual Meeting Publications Journal of Periodontology JOP Online How to Subscribe Missing-Issue Claim Form Back-Issue Order Form JOP Editors Submit Manuscript Clinical Advances in Perio CAP Editors AAP Clinical and ...

  17. Gum Disease in Children

    Science.gov (United States)

    ... Recordings AAP Speakers List 2017 Annual Meeting Publications Journal of Periodontology JOP Online How to Subscribe Missing-Issue Claim Form Back-Issue Order Form JOP Editors Submit Manuscript Clinical Advances in Perio CAP Editors AAP Clinical and ...

  18. Annual Systems Engineering Conference (11th) Held in San Diego, California on October 20-23, 2008. Volume 3

    Science.gov (United States)

    2008-10-23

    CapabilitiesOSGi All BPMN , BPEL, DEX, EDI Msgs Contained in W3C WSDL SOAP Msgs AAP Asset & Logistics Information AAP Commitments UDDI APIs UDDI...APIs OASIS WS-BPEL AAP Collaborative Net-Centric Model (OMG BPMN Business Process Modeling Notation) mapsTo mapsTo mapsTo AAP Business DEXs Messages...processes and activities defined which are then supported by the processes and activities in the BPMN model. Supply Chain Council – SCOR Supply Chain

  19. 78 FR 6113 - Office of Clinical and Preventive Services Indigenous Child Health-Strong Communities, Healthy...

    Science.gov (United States)

    2013-01-29

    ... registration and logistics for meeting. The AAP will subcontract with an organization to assist with these... registration takes approximately one hour to complete ] and SAM registration will take 3-5 business days to... planning will be managed and the specific role of AAP. Describe the AAP's program objectives as they...

  20. Characterization of aspartyl aminopeptidase from Toxoplasma gondii

    Science.gov (United States)

    Zheng, Jun; Cheng, Ziying; Jia, Honglin; Zheng, Yonghui

    2016-01-01

    Aminopeptidases have emerged as new promising drug targets for the development of novel anti-parasitic drugs. An aspartyl aminopeptidase-like gene has been identified in the Toxoplasma gondii genome (TgAAP), although its function remains unknown. In this study, we characterized TgAAP and performed functional analysis of the gene product. Firstly, we expressed a functional recombinant TgAAP (rTgAAP) protein in Escherichia coli, and found that it required metal ions for activity and showed a substrate preference for N-terminal acidic amino acids Glu and Asp. Then, we evaluated the function and drug target potential of TgAAP using the CRISPR/Cas9 knockout system. Western blotting demonstrated the deletion of TgAAP in the knockout strain. Indirect immunofluorescence analysis showed that TgAAP was localized in the cytoplasm of the wild-type parasite, but was not expressed in the knockout strain. Phenotype analysis revealed that TgAAP knockout inhibited the attachment/invasion, replication, and substrate-specific activity in T. gondii. Finally, the activity of drug CID 23724194, previously described as targeting Plasmodium and malarial parasite AAP, was tested against rTgAAP and the parasite. Overall, TgAAP knockout affected the growth of T. gondii but did not completely abolish parasite replication and growth. Therefore, TgAAP may comprise a useful adjunct drug target of T. gondii. PMID:27678060

  1. Structure and function of the adhesive type IV pilus of Sulfolobus acidocaldarius.

    Science.gov (United States)

    Henche, Anna-Lena; Ghosh, Abhrajyoti; Yu, Xiong; Jeske, Torsten; Egelman, Edward; Albers, Sonja-Verena

    2012-12-01

    Archaea display a variety of type IV pili on their surface and employ them in different physiological functions. In the crenarchaeon Sulfolobus acidocaldarius the most abundant surface structure is the aap pilus (archaeal adhesive pilus). The construction of in frame deletions of the aap genes revealed that all the five genes (aapA, aapX, aapE, aapF, aapB) are indispensible for assembly of the pilus and an impact on surface motility and biofilm formation was observed. Our analyses revealed that there exists a regulatory cross-talk between the expression of aap genes and archaella (formerly archaeal flagella) genes during different growth phases. The structure of the aap pilus is entirely different from the known bacterial type IV pili as well as other archaeal type IV pili. An aap pilus displayed 3 stranded helices where there is a rotation per subunit of ∼138° and a rise per subunit of ∼5.7 Å. The filaments have a diameter of ∼110 Å and the resolution was judged to be ∼9 Å. We concluded that small changes in sequence might be amplified by large changes in higher-order packing. Our finding of an extraordinary stability of aap pili possibly represents an adaptation to harsh environments that S. acidocaldarius encounters.

  2. CAM Highlights (FY 82)

    Science.gov (United States)

    1982-11-01

    is a close approxima- tion of a sine wave. One signal train is displaced 90° in phase with respect to the other. This permits detection of...SARMS Cdr, Radford AAP, Attn: SARRA -CO Cdr, Riverbank AAP, Attn: SARRB-CO Cdr, Scranton AAP, Attn: SARSC-CO Cdr, Army Weapons Support Center

  3. Area Array Technology Evaluations for Space and Military Applications

    Science.gov (United States)

    Ghaffarian, Reza

    1996-01-01

    The Jet Propulsion Laboratory (JPL) is currently assessing the use of Area Array Packaging (AAP) for National Aeronautics and Space Administration (NASA) spaceflight applications. this work is being funded through NASA Headquarters, Code Q. The paper discusses background of AAP, objectives, and uses of AAP.

  4. NCBI nr-aa BLAST: CBRC-AGAM-02-0015 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-02-0015 gb|AAP56247.1| deltamethrin resistance-associated NYD-OP1 [Culex pipi...ens pallens] gb|AAP56248.1| deltamethrin resistance-associated NYD-OP2 [Culex pipiens pallens] AAP56247.1 0.0 86% ...

  5. NCBI nr-aa BLAST: CBRC-AGAM-02-0007 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-02-0007 gb|AAP56249.1| deltamethrin resistance-associated NYD-OP3 [Culex pipi...ens pallens] gb|AAP56250.1| deltamethrin resistance-associated NYD-OP4 [Culex pipiens pallens] AAP56249.1 0.0 86% ...

  6. NCBI nr-aa BLAST: CBRC-AGAM-02-0008 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-02-0008 gb|AAP56249.1| deltamethrin resistance-associated NYD-OP3 [Culex pipi...ens pallens] gb|AAP56250.1| deltamethrin resistance-associated NYD-OP4 [Culex pipiens pallens] AAP56249.1 0.0 86% ...

  7. NCBI nr-aa BLAST: CBRC-AGAM-02-0015 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-02-0015 gb|AAP56249.1| deltamethrin resistance-associated NYD-OP3 [Culex pipi...ens pallens] gb|AAP56250.1| deltamethrin resistance-associated NYD-OP4 [Culex pipiens pallens] AAP56249.1 0.0 86% ...

  8. NCBI nr-aa BLAST: CBRC-AGAM-02-0008 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-02-0008 gb|AAP56247.1| deltamethrin resistance-associated NYD-OP1 [Culex pipi...ens pallens] gb|AAP56248.1| deltamethrin resistance-associated NYD-OP2 [Culex pipiens pallens] AAP56247.1 0.0 86% ...

  9. NCBI nr-aa BLAST: CBRC-AGAM-02-0005 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-02-0005 gb|AAP56249.1| deltamethrin resistance-associated NYD-OP3 [Culex pipi...ens pallens] gb|AAP56250.1| deltamethrin resistance-associated NYD-OP4 [Culex pipiens pallens] AAP56249.1 1e-178 81% ...

  10. NCBI nr-aa BLAST: CBRC-AGAM-02-0007 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-02-0007 gb|AAP56247.1| deltamethrin resistance-associated NYD-OP1 [Culex pipi...ens pallens] gb|AAP56248.1| deltamethrin resistance-associated NYD-OP2 [Culex pipiens pallens] AAP56247.1 0.0 86% ...

  11. NCBI nr-aa BLAST: CBRC-ATHA-05-0006 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ATHA-05-0006 gb|AAP45159.1| Plant viral-response family protein [Solanum bulboca...stanum] gb|AAP45189.1| Plant viral-response family protein [Solanum bulbocastanum] AAP45159.1 4e-13 23% ...

  12. NCBI nr-aa BLAST: CBRC-OANA-01-1968 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OANA-01-1968 gb|AAP13045.1| NADH dehydrogenase subunit 2 [Pseudochaenichthys georgia...nus] gb|AAP13046.1| NADH dehydrogenase subunit 2 [Pseudochaenichthys georgianus] AAP13045.1 0.17 23% ...

  13. Microdose study of 14C-acetaminophen with accelerator mass spectrometry to examine pharmacokinetics of parent drug and metabolites in healthy subjects.

    Science.gov (United States)

    Tozuka, Z; Kusuhara, H; Nozawa, K; Hamabe, Y; Ikushima, I; Ikeda, T; Sugiyama, Y

    2010-12-01

    A study of the pharmacokinetics of (14)C-labeled acetaminophen (AAP) was performed in healthy Japanese subjects receiving an oral microdose of the drug. After separation by high-performance liquid chromatography (HPLC), the levels of AAP and its metabolites in the pooled plasma specimens were quantified using accelerator mass spectrometry (AMS). The total body clearance (CL(tot))/bioavailability (F) of AAP was within the variation in the reported values at therapeutic doses, indicating the linearity of AAP pharmacokinetics. AAP-glucuronide (Glu) and AAP-4-O-sulfate satisfied the criteria of safety testing of drug metabolites. AMS could detect AAP-Cys, the active metabolite of AAP conjugated with cysteine, in the urine. Probenecid prolonged the systemic elimination of total radioactivity and caused a marked decrease in AAP-Glu levels in plasma. Probenecid likely inhibited the glucuronidation of AAP and the renal elimination of AAP-4-O-sulfate. Microdosing of (14)C-labeled drug followed by AMS is a powerful tool that can be used in the early phase of drug development for pharmacokinetic analysis of drugs and their metabolites and for detecting the formation of active metabolites in humans.

  14. Transcriptional regulation of cytosol and membrane alanyl-aminopeptidase in human T cell subsets.

    Science.gov (United States)

    Bukowska, Alicja; Tadje, Janine; Arndt, Marco; Wolke, Carmen; Kähne, Thilo; Bartsch, Jaqueline; Faust, Jürgen; Neubert, Klaus; Hashimoto, Yuichi; Lendeckel, Uwe

    2003-04-01

    Aminopeptidase inhibitors strongly affect the proliferation and function of immune cells in man and animals and are promising agents for the pharmacological treatment of inflammatory or autoimmune diseases. Membrane alanyl-aminopeptidase (mAAP) has been considered as the major target of these anti-inflammatory aminopeptidase inhibitors. Recent evidence also points to a role of the cytosol alanyl-aminopeptidase (cAAP) in the immune response. In this study we used quantitative RT-PCR to determine the mRNA expression of both cAAP and mAAP in resting and activated peripheral T cells and also in CD4+, CD8+, Th1, Th2 and Treg (CD4+ CD25+) subpopulations. Both mAAP and cAAP mRNAs were expressed in all cell types investigated, and in response to activation their expression appeared to be upregulated in CD8+ cells, but downregulated in Treg cells. In CD4+ cells, mAAP and cAAP mRNAs were affected in opposite ways in response to activation. The cAAP-specific inhibitor, PAQ-22, did not affect either cAAP or mAAP expression in activated CD4+ or CD8+ cells, whereas in activated Treg cells it markedly upregulated the mRNA levels of both aminopeptidases. The non-discriminatory inhibitor, phebestin, significantly increased the amount of mAAP and cAAP mRNA in CD4+ and that of cAAP in Treg cells.

  15. Differences between African Americans and Whites in reactions to affirmative action programs in hiring, promotion, training, and layoffs.

    Science.gov (United States)

    Levi, Ariel S; Fried, Yitzhak

    2008-09-01

    This study examines the reactions of African Americans and Whites to affirmative action programs (AAPs) applied to 4 human resource activities: hiring, promotion, training, and layoffs. The results of a scenario-based experimental study conducted on a large sample (N > 800) of advanced undergraduate and MBA business school participants generally supported the hypothesis that human resource activity elicited systematic differences in reaction to AAPs between African Americans and Whites. The authors also replicated previous research on the effect of AAP strength and prior discrimination by the organization on reactions to AAPs. Results indicated that AAP strength levels moderated racial differences in reaction to AAPs, while the moderating role of prior discrimination by the organization was not supported. Implications for future research are discussed.

  16. Reactions to two versions of affirmative action among whites, blacks, and Hispanics.

    Science.gov (United States)

    Kravitz, D A; Klineberg, S L

    2000-08-01

    Houston-area Whites (n = 414), Blacks (n = 392), American-born Hispanics (n = 162), and Hispanic immigrants (n = 177) evaluated a self-defined "typical" affirmative action plan (AAP) and a tiebreak AAP that applies under conditions of equal qualifications and underrepresentation. Whites preferred Tiebreak; Blacks and Hispanics preferred the typical AAP. The groups differed in beliefs about the procedures and fairness of affirmative action (AA), perceptions of workplace discrimination, and political orientations. Perceived fairness predicted support for both AAPs in all American-born groups, but the impact of other predictors varied greatly across AAPs and ethnic groups. The results clarify the bases for Whites' opposition to AA as they construe it. The results also underscore the importance of specifying the AAP procedures, of uncovering the predictors of AA attitudes among target-group members, and of conducting separate analyses in each ethnic community.

  17. Preparation and pharmaceutical evaluation of acetaminophen nano-fiber tablets: Application of a solvent-based electrospinning method for tableting.

    Science.gov (United States)

    Hamori, Mami; Nagano, Kana; Kakimoto, Sayaka; Naruhashi, Kazumasa; Kiriyama, Akiko; Nishimura, Asako; Shibata, Nobuhito

    2016-03-01

    In this study, we developed nano-fiber-based tablets with acetaminophen (AAP; LogPow=0.51) for controlled-release delivery systems and evaluated in vitro drug dissolution and in vivo pharmacokinetics in rats. Nano-fibers made from methacrylic acid copolymer S (MAC; EUDRAGIT S100) and containing AAP were prepared using a solvent-based electrospinning (ES) method. In vitro dissolution rate profiles of AAP showed tableting pressure-dependent decreases and pH-dependent increases. The results of tablet tracking by X-ray irradiation showed tablets based on MAC nano-fibers did not disintegrate in the upper intestinal lumen and had the properties of a long-term-acting tablet. In addition, the in vitro release profiles of AAP from nano-fiber tablets prepared by dissolving MAC with AAP (NFT), nano-fiber tablets prepared by adsorbing AAP to drug-free MAC nano-fibers (NFTadso), and tablets prepared by adsorbing half the amount of AAP to MAC nano-fibers containing the remaining amount of AAP (NFThalf) showed independent controlled-release aspects of AAP compared with physical mixture tablets (PMT). In vivo pharmacokinetic studies in rats after intraduodenal administration of 14 mg/rat AAP in NFT, NFTadso, and NFThalf demonstrated that all these tablets based on MAC nano-fibers showed sustained-release profiles compared with PMT, and showed ultra-sustained release properties for AAP. These new tablets based on MAC nano-fibers did not disintegrate in the intestine in the lower pH region, and the tablets could regulate the release of AAP in a pH-dependent manner. The ES method is a useful technique to prepare nano-fibers and showed promising results as an oral delivery system for sustained-release regulation.

  18. Acetaminophen induces apoptosis in rat cortical neurons.

    Directory of Open Access Journals (Sweden)

    Inmaculada Posadas

    Full Text Available BACKGROUND: Acetaminophen (AAP is widely prescribed for treatment of mild pain and fever in western countries. It is generally considered a safe drug and the most frequently reported adverse effect associated with acetaminophen is hepatotoxicity, which generally occurs after acute overdose. During AAP overdose, encephalopathy might develop and contribute to morbidity and mortality. Our hypothesis is that AAP causes direct neuronal toxicity contributing to the general AAP toxicity syndrome. METHODOLOGY/PRINCIPAL FINDINGS: We report that AAP causes direct toxicity on rat cortical neurons both in vitro and in vivo as measured by LDH release. We have found that AAP causes concentration-dependent neuronal death in vitro at concentrations (1 and 2 mM that are reached in human plasma during AAP overdose, and that are also reached in the cerebrospinal fluid of rats for 3 hours following i.p injection of AAP doses (250 and 500 mg/kg that are below those required to induce acute hepatic failure in rats. AAP also increases both neuronal cytochrome P450 isoform CYP2E1 enzymatic activity and protein levels as determined by Western blot, leading to neuronal death through mitochondrial-mediated mechanisms that involve cytochrome c release and caspase 3 activation. In addition, in vivo experiments show that i.p. AAP (250 and 500 mg/kg injection induces neuronal death in the rat cortex as measured by TUNEL, validating the in vitro data. CONCLUSIONS/SIGNIFICANCE: The data presented here establish, for the first time, a direct neurotoxic action by AAP both in vivo and in vitro in rats at doses below those required to produce hepatotoxicity and suggest that this neurotoxicity might be involved in the general toxic syndrome observed during patient APP overdose and, possibly, also when AAP doses in the upper dosing schedule are used, especially if other risk factors (moderate drinking, fasting, nutritional impairment are present.

  19. Auricularia auricular polysaccharide-low molecular weight chitosan polyelectrolyte complex nanoparticles: Preparation and characterization

    Directory of Open Access Journals (Sweden)

    Wei Xiong

    2016-06-01

    Full Text Available Novel polyelectrolyte complex nanoparticles (AAP/LCS NPs were prepared in this study and these were produced by mixing negatively charged auricularia auricular polysaccharide (AAP with positively charged low molecular weight chitosan (LCS in an aqueous medium. The AAP was extracted and purified from auricularia auricular, and then characterized by micrOTOF-Q mass spectrometry, UV/Vis spectrophotometry, moisture analyzer and SEM. The yield, moisture, and total sugar content of the AAP were 4.5%, 6.2% and 90.12% (w/w, respectively. The AAP sample was water-soluble and exhibited white flocculence. The characteristics of AAP/LCS NPs, such as the particle size, zeta potential, morphology, FT-IR spectra, DSC were investigated. The results obtained revealed that the AAP/LCS NPs had a spherical shape with a diameter of 223 nm and a smooth surface, and the results of the FT-IR spectra and DSC investigations indicated that there was an electrostatic interaction between the two polyelectrolyte polymers. Bovine serum albumin (BSA, pI = 4.8 and bovine hemoglobin (BHb, pI = 6.8 were used as model drugs to investigate the loading and release features of the AAP/LCS NPs. The results obtained showed that the AAP/LCS NPs had a higher entrapment efficiency (92.6% for BHb than for BSA (81.5%. The cumulative release of BSA and BHb from AAP/LCS NPs after 24 h in vitro was 95.4% and 91.9%, respectively. The in vitro release demonstrated that AAP/LCS NPs provided a sustained release matrix suitable for the delivery of protein drugs. These studies demonstrate that AAP/LCS NPs have a very promising potential as a delivery system for protein drugs.

  20. 78 FR 57874 - Federal Property Suitable as Facilities to Assist the Homeless

    Science.gov (United States)

    2013-09-20

    ... Assistant Secretary for Community Planning and Development, HUD. ACTION: Notice. SUMMARY: This Notice... kitchen Reasons: Extensive deterioration Tennessee J0139 Milan AAP Milan TN 38358 Landholding Agency:...

  1. Aerobic Anoxygenic Phototrophic Bacteria in the Mid-Atlantic Bight and the North Pacific Gyre. Revised

    Science.gov (United States)

    Cottrell, Matthew T.; Mannino, Antonio; Kirchman, David L.

    2005-01-01

    The abundance of aerobic anoxygenic phototrophic (AM) bacteria, cyanobacteria and heterotrophs was examined in the Mid-Atlantic Bight and the central North Pacific gyre using infrared fluorescence microscopy coupled with image analysis and flow cytometry. AAP bacteria comprised 5% to 16% of total prokaryotes in the Atlantic but only 5% or less in the Pacific. In the Atlantic, AAP bacterial abundance was as much as 2-fold higher than Prochlorococcus and 10-folder higher than Synechococcus. In contrast, Prochlorococcus outnumbered AAP bacteria 5- to 50-fold in the Pacific. In both oceans, subsurface abundance maxima occurred within the photic zone, and AAP bacteria were least abundant below the 1% light depth. Concentrations of bacteriochlorophyll a (BChl a) were low (approx.1%) compared to chlorophyll a. Although the BChl a content of AAP bacteria per cell was typically 20- to 250-fold lower than the divinyl-chlorophyll a content of Prochlorococcus, in shelf break water the pigment content of AAP bacteria approached that of Prochlorococcus. The abundance of AAP bacteria rivaled some groups of strictly heterotrophic bacteria and was often higher than the abundance of known AAP genera (Erythrobacter and Roseobacter spp.). The distribution of AAP bacteria in the water column, which was similar in the Atlantic and the Pacific, was consistent with phototrophy.

  2. PRECIPITATION EFFECTS ON SOIL CHARACTERISTICS IN TROPICAL RAIN FORESTS OF THE CHOCO BIOGEOGRAPHICAL REGION

    Directory of Open Access Journals (Sweden)

    Harley Quinto Mosquera

    2016-01-01

    Full Text Available Average annual precipitation (AAP is one of the principal environmental factors that regulates processes in terrestrial ecosystems. The effect of AAP on the availability of edaphic nutrients is poorly understood, especially in tropical zones with high rainfall. In order to evaluate the effects of high AAP on the availability of soil N, P, and K, physicochemical parameters were measured in soils of three tropical rainforests in the Chocó biogeographical region with different AAPs (7,500, 8,000, and 10,000 mm yr-1. Furthermore, a bibliographical review was carried out that including studies for distinct tropical Ultisols and AAP ranging from 1,800 to 10,000 mm yr-1. The evaluated soils presented extreme acidity with high contents of Al, organic matter (OM and total N, and low quantities of P, Mg, and Ca. The K concentrations were intermediate and the effective cation exchange capacity (ECEC was low. On the other hand, in the evaluation of the influence of the AAP on the availability of N, P, and K in the soil, contrasting tendencies were observed. On one side, a positive curvilinear relationship was found between the availability of N and the increase in the AAP. On the other side, the available P content significantly decreased with increasing AAP. In conclusion, the excessive AAP resulted in increases in total N and low availability of P, thereby altering the dynamics of the nutrients and the carbon balance of the tropical forest

  3. Ascorbic acid 6-palmitate suppresses gap-junctional intercellular communication through phosphorylation of connexin 43 via activation of the MEK-ERK pathway.

    Science.gov (United States)

    Lee, Kyung Mi; Kwon, Jung Yeon; Lee, Ki Won; Lee, Hyong Joo

    2009-01-15

    Although the health benefits of dietary antioxidants have been extensively studied, their potential negative effects remain unclear. L-Ascorbic acid 6-palmitate (AAP), a synthetic derivative of ascorbic acid (AA), is widely used as an antioxidant and preservative in foods, vitamins, drugs, and cosmetics. Previously, we found that AA exerted an antitumor effect by protecting inhibition of gap-junctional intercellular communication (GJIC), which is closely associated with tumor progression. In this study, we examined whether AAP, an amphipathic derivative of AA, has chemopreventive effects using a GJIC model. AAP and AA exhibited dose-dependent free radical-scavenging activities and inhibited hydrogen peroxide (H(2)O(2))-induced intracellular reactive oxygen species (ROS) production in normal rat liver epithelial cells. Unexpectedly, however, AAP did not protect against the inhibition of GJIC induced by H(2)O(2); instead, it inhibited GJIC synergistically with H(2)O(2). AAP inhibited GJIC in a dose-dependent and reversible manner. This inhibitory effect was not due to the conjugated lipid structure of AAP, as treatment with palmitic acid alone failed to inhibit GJIC under the same conditions. The inhibition of GJIC by AAP was restored in the presence of mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitor U0126, but not in the presence of other signal inhibitors and antioxidant (PKC inhibitors, EGFR inhibitor, NADPH oxidase inhibitor, catalase, vitamin E, or AA), indicating the critical involvement of MEK signaling in the GJIC inhibitory activity of AAP. Phosphorylation of ERK and connexin 43 (Cx43) was observed following AAP treatment, and this was reversed by U0126. These results suggest that the AAP-induced inhibition of GJIC is mediated by the phosphorylation of Cx43 via activation of the MEK-ERK pathway. Taken together, our results indicate that AAP has a potent carcinogenic effect, and that the influence of dietary

  4. Increasing Availability to and Ascertaining Value of Asthma Action Plans in Schools through Use of Technology and Community Collaboration

    Science.gov (United States)

    Hanson, Tabitha K.; Aleman, Martha; Hart, Lacey; Yawn, Barbara

    2013-01-01

    Background: Approximately 9% of school-aged children in the United States have asthma. Since 1997, the Asthma Action Plan (AAP) has been recommended as an asthma self-management tool for individuals with asthma. In the school setting, the use of the AAP has been primarily dependent on communication between the family and the school through a paper…

  5. Reference: 579 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available amounts, and plants frequently make use of these nitrogen sources. The goal of this study was to identify tr...ant role of AAP1 for efficient use of nitrogen sources present in the rhizosphere. AAP1 transports uncharged

  6. 48 CFR 307.104 - General procedures.

    Science.gov (United States)

    2010-10-01

    ... standard format for an AAP. The template for the plan is available on the ASFR/OGAPA/DA Internet Web site. For the data elements specified in the AAP format, the HCA/CCO may include information in addition to... monitoring. (4) The HCA/CCO and Small Business Specialist (SBS) in the Office of Small and...

  7. Pediatric Microdose Study of [14C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept

    NARCIS (Netherlands)

    Mooij, M.G.; Duijn, E. van; Knibbe, C.A.J.; Windhorst, A.D.; Hendrikse, N.H.; Vaes, W.H.J.; Spaans, E.; Fabriek, B.O.; Sandman, H.; Grossouw, D.; Hanff, L.M.; Janssen, P.J.J.M.; Koch, B.C.P.; Tibboel, D.; de Wildt, S.N.

    2014-01-01

    Results: Ten infants (aged 0.1–83.1 months) were included; one was excluded as he vomited shortly after administration. In nine patients, [14C]AAP and metabolites in blood samples were detectable at expected concentrations: median (range) maximum concentration (Cmax) [14C]AAP 1.68 (0.75–4.76) ng/L,

  8. Pediatric Microdose Study of [14C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept

    NARCIS (Netherlands)

    M.G. Mooij (Miriam); E. van Duijn (Esther); C.A.J. Knibbe (Catherijne); A.D. Windhorst (Albert); N.H. Hendrikse (N. Harry); W.H.J. Vaes (Wouter H. J.); E. Spaans (Edwin); B.O. Fabriek (Babs); H. Sandman (Hugo); D. Grossouw (Dimitri); L.M. Hanff (Lidwien); P.J.J.M. Janssen (Paul); B.C.P. Koch (Birgit C. P.); D. Tibboel (Dick); S.N. de Wildt (Saskia)

    2014-01-01

    textabstractResults: Ten infants (aged 0.1–83.1 months) were included; one was excluded as he vomited shortly after administration. In nine patients, [14C]AAP and metabolites in blood samples were detectable at expected concentrations: median (range) maximum concentration (Cmax) [14C]AAP 1.68 (0.75–

  9. Enzymuria in neonates receiving continuous intravenous infusion of gentamicin

    DEFF Research Database (Denmark)

    Colding, H; Brygge, K; Brendstrup, L;

    1992-01-01

    with non-treatment periods in the same newborn infant (33 infants). The same tendency applied to AAP. Newborn infants receiving continuous intravenous infusion of gentamicin were not found to be at greater risk of nephrotoxicity than those receiving intermittent gentamicin treatment, using NAG and AAP...

  10. Rapid induction of hepatocyte growth factor mRNA after administration of gomisin A, a lignan component of shizandra fruits.

    Science.gov (United States)

    Shiota, G; Yamada, S; Kawasaki, H

    1996-11-01

    Gomisin A (Go), a lignan component of shizandra fruits, protects the liver from injury by acetaminophen (AAP). One of its possible mechanisms is supposed to be related to the suppression of lipid peroxidation. Since hepatocyte growth factor (HGF) was reported to prevent hepatotoxin-induced liver damage, we tested HGF as the intermediary of Go effects. Simultaneous analyses of HGF mRNA expression and liver histology in rats were performed at 6 and 24 hr after treatment with AAP, Go or both. HGF mRNA rapidly expressed at 6 hr after Go treatment, while no HGF mRNA was observed at 6 hr after AAP treatment. Induction of HGF mRNA at 24 hr was observed after treatment with AAP or AAP plus Go. Histological findings indicate that massive necrosis and vacuolization in the liver of rats treated with both AAP and Go were reduced in comparison with rats treated with AAP only. These data suggest that Go rapidly induces HGF mRNA through different mechanisms from AAP-induced liver injury.

  11. NCBI nr-aa BLAST: CBRC-GGOR-01-1322 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GGOR-01-1322 gb|AAP44475.1| transient receptor potential cation channel subfam...ily M member 4 splice variant C [Homo sapiens] gb|EAW52460.1| transient receptor potential cation channel, subfamily M, member 4, isoform CRA_a [Homo sapiens] AAP44475.1 3e-28 87% ...

  12. A plasma membrane association module in yeast amino acid transporters

    NARCIS (Netherlands)

    Popov-Čeleketić, Dušan; Bianchi, Frans; Ruiz, Stephanie J; Meutiawati, Febrina; Poolman, Bert

    2016-01-01

    Amino acid permeases (AAPs) in the plasma membrane (PM) of Saccharomyces cerevisiae are responsible for the uptake of amino acids and involved in regulation of their cellular levels. Here, we report on a strong and complex module for PM association found in the C-terminal tail of AAPs. Using in sili

  13. TEMPLATE POLYMERIZATION OF N-VINYLIMIDAZOLE ALONG POLY(METHACRYLIC ACID) IN WATER .3. MOLECULAR-WEIGHTS OF THE FORMED POLYMERS

    NARCIS (Netherlands)

    VANDEGRAMPEL, HT; TAN, YY; CHALLA, G

    1991-01-01

    The molecular weights of polymers formed in the template polymerization of N-vinylimidazole (VIm) along poly(methacrylic acid) (PMAA) in water at 50-degrees-C using 2,2'-azobis(2-amidinopropane)-2HCl (AAP) as initiator were determined for variable [PMAA] to [VIm]0 ratios, [VIm]0, [AAP]0, and templat

  14. Kinetic, spectroscopic, and X-ray crystallographic characterization of the functional E151H aminopeptidase from Aeromonas proteolytica.

    Science.gov (United States)

    Bzymek, Krzysztof P; Moulin, Aaron; Swierczek, Sabina I; Ringe, Dagmar; Petsko, Gregory A; Bennett, Brian; Holz, Richard C

    2005-09-13

    Glutamate151 (E151) has been shown to be catalytically essential for the aminopeptidase from Vibrio proteolyticus (AAP). E151 acts as the general acid/base during the catalytic mechanism of peptide hydrolysis. However, a glutamate residue is not the only residue capable of functioning as a general acid/base during catalysis for dinuclear metallohydrolases. Recent crystallographic characterization of the D-aminopeptidase from Bacillus subtilis (DppA) revealed a histidine residue that resides in an identical position to E151 in AAP. Because the active-site ligands for DppA and AAP are identical, AAP has been used as a model enzyme to understand the mechanistic role of H115 in DppA. Substitution of E151 with histidine resulted in an active AAP enzyme exhibiting a kcat value of 2.0 min(-1), which is over 2000 times slower than r AAP (4380 min(-1)). ITC experiments revealed that ZnII binds 330 and 3 times more weakly to E151H-AAP compared to r-AAP. UV-vis and EPR spectra of CoII-loaded E151H-AAP indicated that the first metal ion resides in a hexacoordinate/pentacoordinate equilibrium environment, whereas the second metal ion is six-coordinate. pH dependence of the kinetic parameters kcat and K(m) for the hydrolysis of L-leucine p-nitroanilide (L-pNA) revealed a change in an ionization constant in the enzyme-substrate complex from 5.3 in r-AAP to 6.4 in E151H-AAP, consistent with E151 in AAP being the active-site general acid/base. Proton inventory studies at pH 8.50 indicate the transfer of one proton in the rate-limiting step of the reaction. Moreover, the X-ray crystal structure of [ZnZn(E151H-AAP)] has been solved to 1.9 A resolution, and alteration of E151 to histidine does not introduce any major conformational changes to the overall protein structure or the dinuclear ZnII active site. Therefore, a histidine residue can function as the general acid/base in hydrolysis reactions of peptides and, through analogy of the role of E151 in AAP, H115 in DppA likely

  15. Use of the adult attachment projective picture system in psychodynamic psychotherapy with a severely traumatized patient.

    Science.gov (United States)

    George, Carol; Buchheim, Anna

    2014-01-01

    The following case study is presented to facilitate an understanding of how the attachment information evident from Adult Attachment Projective Picture System (AAP) assessment can be integrated into a psychodynamic perspective in making therapeutic recommendations that integrate an attachment perspective. The Adult Attachment Projective Picture System (AAP) is a valid representational measure of internal representations of attachment based on the analysis of a set of free response picture stimuli designed to systematically activate the attachment system (George and West, 2012). The AAP provides a fruitful diagnostic tool for psychodynamic-oriented clinicians to identify attachment-based deficits and resources for an individual patient in therapy. This paper considers the use of the AAP with a traumatized patient in an inpatient setting and uses a case study to illustrate the components of the AAP that are particularly relevant to a psychodynamic conceptualization. The paper discusses also attachment-based recommendations for intervention.

  16. Extraction and characterization of the auricularia auricular polysaccharide

    Science.gov (United States)

    Zhang, Q. T.

    2016-07-01

    To study a new protein drugs carrier, the Auricularia auricular polysaccharide (AAP) was extracted and purified from Auricularia auricular, and then characterized by the micrOTOF-Q mass spectrometer, UV/Vis spectrophotometer, moisture analyzer and SEM. The results showed that the AAP sample was water- soluble and white flocculence, its molecular weight were 20506.9 Da∼⃒63923.7 Da, and the yield, moisture, and total sugar contents of the AAP were 4.5%, 6.2% and 90.12%(w/w), respectively. The results of the SEM revealed that the AAP dried by vacuum were spherical particles with a smooth surface, and the AAP freeze-dried had continuous porous sheet shape with the loose structure.

  17. Acetaminophen induces human neuroblastoma cell death through NFKB activation.

    Directory of Open Access Journals (Sweden)

    Inmaculada Posadas

    Full Text Available Neuroblastoma resistance to apoptosis may contribute to the aggressive behavior of this tumor. Therefore, it would be relevant to activate endogenous cellular death mechanisms as a way to improve neuroblastoma therapy. We used the neuroblastoma SH-SY5Y cell line as a model to study the mechanisms involved in acetaminophen (AAP-mediated toxicity by measuring CYP2E1 enzymatic activity, NFkB p65 subunit activation and translocation to the nucleus, Bax accumulation into the mitochondria, cytochrome c release and caspase activation. AAP activates the intrinsic death pathway in the SH-SY5Y human neuroblastoma cell line. AAP metabolism is partially responsible for this activation, because blockade of the cytochrome CYP2E1 significantly reduced but did not totally prevent, AAP-induced SH-SY5Y cell death. AAP also induced NFkB p65 activation by phosphorylation and its translocation to the nucleus, where NFkB p65 increased IL-1β production. This increase contributed to neuroblastoma cell death through a mechanism involving Bax accumulation into the mitochondria, cytochrome c release and caspase3 activation. Blockade of NFkB translocation to the nucleus by the peptide SN50 prevented AAP-mediated cell death and IL-1β production. Moreover, overexpression of the antiapoptotic protein Bcl-x(L did not decrease AAP-mediated IL-1β production, but prevented both AAP and IL-1β-mediated cell death. We also confirmed the AAP toxic actions on SK-N-MC neuroepithelioma and U87MG glioblastoma cell lines. The results presented here suggest that AAP activates the intrinsic death pathway in neuroblastoma cells through a mechanism involving NFkB and IL-1β.

  18. Monoclonal antibodies against accumulation-associated protein affect EPS biosynthesis and enhance bacterial accumulation of Staphylococcus epidermidis.

    Directory of Open Access Journals (Sweden)

    Jian Hu

    Full Text Available Because there is no effective antibiotic to eradicate Staphylococcus epidermidis biofilm infections that lead to the failure of medical device implantations, the development of anti-biofilm vaccines is necessary. Biofilm formation by S. epidermidis requires accumulation-associated protein (Aap that contains sequence repeats known as G5 domains, which are responsible for the Zn(2+-dependent dimerization of Aap to mediate intercellular adhesion. Antibodies against Aap have been reported to inhibit biofilm accumulation. In the present study, three monoclonal antibodies (MAbs against the Aap C-terminal single B-repeat construct followed by the 79-aa half repeat (AapBrpt1.5 were generated. MAb(18B6 inhibited biofilm formation by S. epidermidis RP62A to 60% of the maximum, while MAb(25C11 and MAb(20B9 enhanced biofilm accumulation. All three MAbs aggregated the planktonic bacteria to form visible cell clusters. Epitope mapping revealed that the epitope of MAb(18B6, which recognizes an identical area within AapBrpt constructs from S. epidermidis RP62A, was not shared by MAb(25C11 and MAb(20B9. Furthermore, all three MAbs were found to affect both Aap expression and extracellular polymeric substance (EPS, including extracellular DNA and PIA biosynthesis in S. epidermidis and enhance the cell accumulation. These findings contribute to a better understanding of staphylococcal biofilm formation and will help to develop epitope-peptide vaccines against staphylococcal infections.

  19. Diversity and Distribution of Freshwater Aerobic Anoxygenic Phototrophic Bacteria across a Wide Latitudinal Gradient

    Science.gov (United States)

    Ferrera, Isabel; Sarmento, Hugo; Priscu, John C.; Chiuchiolo, Amy; González, José M.; Grossart, Hans-Peter

    2017-01-01

    Aerobic anoxygenic phototrophs (AAPs) have been shown to exist in numerous marine and brackish environments where they are hypothesized to play important ecological roles. Despite their potential significance, the study of freshwater AAPs is in its infancy and limited to local investigations. Here, we explore the occurrence, diversity and distribution of AAPs in lakes covering a wide latitudinal gradient: Mongolian and German lakes located in temperate regions of Eurasia, tropical Great East African lakes, and polar permanently ice-covered Antarctic lakes. Our results show a widespread distribution of AAPs in lakes with contrasting environmental conditions and confirm that this group is composed of different members of the Alpha- and Betaproteobacteria. While latitude does not seem to strongly influence AAP abundance, clear patterns of community structure and composition along geographic regions were observed as indicated by a strong macro-geographical signal in the taxonomical composition of AAPs. Overall, our results suggest that the distribution patterns of freshwater AAPs are likely driven by a combination of small-scale environmental conditions (specific of each lake and region) and large-scale geographic factors (climatic regions across a latitudinal gradient). PMID:28275369

  20. A polyphenol extract of Hibiscus sabdariffa L. ameliorates acetaminophen-induced hepatic steatosis by attenuating the mitochondrial dysfunction in vivo and in vitro.

    Science.gov (United States)

    Lee, Chao-Hsin; Kuo, Chih-Yi; Wang, Chau-Jong; Wang, Chi-Ping; Lee, Yi-Ru; Hung, Chi-Nan; Lee, Huei-Jane

    2012-01-01

    Oxidative stress is the major contributor to acetaminophen (AAP)-caused liver damage. It promotes mitochondrial oxidative stress and collapses the mitochondrial membrane potential to cause cell death. We have previously shown that a polyphenol extract of Hibiscus sabdariffa L. (HPE) potentiated the antioxidative effect. We further examined in this study the possible mechanism of HPE against AAP-caused liver damage. BABL/c mice were orally fed with HPE (100, 200 or 300 mg/kg) for two weeks prior to an i.p. injection of 1000 mg/kg of AAP. The mice were decapitated 6 h after the AAP injection to collect the blood and liver for further determination. The results show that pretreating with HPE increased the level of glutathione (GSH), decreased the level of lipid peroxidation, and increased catalase activity in the liver. A histopathological evaluation shows that HPE could decrease AAP-induced liver sterosis accompanied by a decreased expression of AIF, Bax, Bid, and p-JNK in the liver. An in vitro assay revealed that HPE could reduce AAP-induced death of BABL/c normal liver cells (BNLs), reverse the lost mitochondrial potency and improve the antioxidative status, similarly to the results of the in vivo assay. We show in this study that HPE possessed the ability to protect the liver from AAP-caused injury. The protective mechanism might be regulated by decreasing oxidative stress and attenuating the mitochondrial dysfunction.

  1. Use of the Adult Attachment Projective Picture System in Psychodynamic Psychotherapy with a Severely Traumatized Patient

    Directory of Open Access Journals (Sweden)

    Carol eGeorge

    2014-08-01

    Full Text Available The Adult Attachment Projective Picture System (AAP is a valid representational measure of internal representations of attachment based on the analysis of a set of free response picture stimuli designed to systematically activate the attachment system (George & West, 2012. The AAP provides a fruitful diagnostic tool for psychodynamic-oriented clinicians to identify attachment-based deficits and resources for an individual patient in therapy. This paper considers the use of the AAP with a traumatized patient in an inpatient setting and uses a case study to illustrate the components of the AAP that are particularly relevant to a psychodynamic conceptualization. The paper discusses also attachment-based recommendations for intervention.

  2. Sleep and Newborns

    Science.gov (United States)

    ... AAP introduced this recommendation in 1992. Use a firm sleep surface. Cover the mattress with a sheet ... Sleep and Your 1- to 2-Year-Old Communication and Your Newborn Medical Care and Your Newborn ...

  3. Pediatricians Say No to Wearable Smartphone Baby Monitors

    Science.gov (United States)

    ... Academy of Pediatrics (AAP) recommends against using these high-tech baby monitors in healthy infants, said Dr. Rachel ... Owlet responded that the company has performed "extensive product safety testing," adding that its Smart Sock is ...

  4. Circumcision

    Science.gov (United States)

    Circumcision is a surgical procedure to remove the foreskin, the skin that covers the tip of the ... AAP), there are medical benefits and risks to circumcision. Possible benefits include a lower risk of urinary ...

  5. Baltimore Eesti Selts - 75 / Vilve Ladon ; fotod: Fred Ise

    Index Scriptorium Estoniae

    Ladon, Vilve

    2010-01-01

    Baltimore Eesti Majas tähistati 2. okt. 2010 Baltimore Eesti Seltsi aastapäeva. Eesti suursaatkonna esimene sekretär poliitilistes küsimustes Aap Neljas edastas president Toomas Hendrik Ilvese tervituse

  6. Measles, Mumps, Rubella (MMR)

    Science.gov (United States)

    ... at Each Vaccine: MMR (Measles, Mumps and Rubella) Vaccine Children's Hospital of Philadelphia (CHOP): Learn about measles, how ... Disease Control and Prevention AAP Urges Parents to Vaccinate Children to Protect Against Measles (1/23/15) American ...

  7. Cow's milk - infants

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/002448.htm Cow's milk - infants To use the sharing features on this ... old, you should not feed your baby cow's milk, according to the American Academy of Pediatrics (AAP). ...

  8. ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs

    DEFF Research Database (Denmark)

    Xing, Dezhi; Kjølbye, Anne Louise; Nielsen, Morten S;

    2003-01-01

    INTRODUCTION: The aim of this study was to determine if the stable antiarrhythmic peptide (AAP) analogue ZP123 increases gap junctional intercellular conductance and prevents reentrant ventricular tachycardia (VT) during coronary artery occlusion. METHODS AND RESULTS: Voltage clamp experiments de...

  9. One Family's Struggles with Hepatitis B

    Medline Plus

    Full Text Available ... Tos Ferina AAP CME ask your doctor brochure family stories faq meet dr. gary freed meet keri ... media video/audio pneumonia tb overview links & resources families advocacy about civil rights kids' rights sample school ...

  10. One Family's Struggle with Chickenpox

    Medline Plus

    Full Text Available ... Tos Ferina AAP CME ask your doctor brochure family stories faq meet dr. gary freed meet keri ... media video/audio pneumonia tb overview links & resources families advocacy about civil rights kids' rights sample school ...

  11. One Family's Struggles with HPV (Human Papillomavirus)

    Medline Plus

    Full Text Available ... Tos Ferina AAP CME ask your doctor brochure family stories faq meet dr. gary freed meet keri ... media video/audio pneumonia tb overview links & resources families advocacy about civil rights kids' rights sample school ...

  12. One Family's Struggles with Pertussis (Whooping Cough)

    Medline Plus

    Full Text Available ... Tos Ferina AAP CME ask your doctor brochure family stories faq meet dr. gary freed meet keri ... media video/audio pneumonia tb overview links & resources families advocacy about civil rights kids' rights sample school ...

  13. Improving Family Communications

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Listen Español Text Size Email Print Share Improving Family Communications Page Content Article Body How can I ...

  14. Roles within the Family

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Text Size Email Print Share Roles Within the Family Page Content Article Body Families are not democracies. ...

  15. Normal Functioning Family

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Español Text Size Email Print Share Normal Functioning Family Page Content Article Body Is there any way ...

  16. Myth of the Perfect Family

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Español Text Size Email Print Share The "Perfect" Family Page Content Article Body Is there such a ...

  17. Family Disruptions

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Life Listen Español Text Size Email Print Share Family Disruptions Page Content Article Body No matter how ...

  18. One Family's Struggles with Rotavirus

    Medline Plus

    Full Text Available ... Tos Ferina AAP CME ask your doctor brochure family stories faq meet dr. gary freed meet keri ... media video/audio pneumonia tb overview links & resources families advocacy about civil rights kids' rights sample school ...

  19. Family Arguments

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Life Listen Español Text Size Email Print Share Family Arguments Page Content Article Body We seem to ...

  20. Approaches to. Establish for Major Food Aller

    Science.gov (United States)

    ... J. Food Treatments to ibdtpe The best example of food prod@s that ... AAP) dct~~~~$ that ~~f~~~~a could be considered 'hypoallergenic” if challenge ...

  1. Ecology of aerobic anoxygenic phototrophs in aquatic environments.

    Science.gov (United States)

    Koblížek, Michal

    2015-11-01

    Recognition of the environmental role of photoheterotrophic bacteria has been one of the main themes of aquatic microbiology over the last 15 years. Aside from cyanobacteria and proteorhodopsin-containing bacteria, aerobic anoxygenic phototrophic (AAP) bacteria are the third most numerous group of phototrophic prokaryotes in the ocean. This functional group represents a diverse assembly of species which taxonomically belong to various subgroups of Alpha-, Beta- and Gammaproteobacteria. AAP bacteria are facultative photoheterotrophs which use bacteriochlorophyll-containing reaction centers to harvest light energy. The light-derived energy increases their bacterial growth efficiency, which provides a competitive advantage over heterotrophic species. Thanks to their enzymatic machinery AAP bacteria are active, rapidly growing organisms which contribute significantly to the recycling of organic matter. This chapter summarizes the current knowledge of the ecology of AAP bacteria in aquatic environments, implying their specific role in the microbial loop.

  2. Indications of atypical antipsychotics in the elderly.

    Science.gov (United States)

    McKean, Andrew; Monasterio, Erik

    2015-01-01

    Atypical antipsychotics (AAP) have become some of the most commonly prescribed medications in primary and specialist care settings. Off-label prescribing accounts for much of the expanded use of AAPs. This has become common in the elderly. Marketing by pharmaceutical companies appears to have contributed to the off-label use of AAPs, in situations where their safety and efficacy is far from established. Although evidence provides varying degrees of support for their use for behavioural and psychological symptoms of dementia, augmentation of antidepressants in depression, anxiety, insomnia and in the management of psychosis in Parkinson's Disease, there are a number of potential problems with their expanded use in the elderly. These include weight gain, type two diabetes mellitus, sudden cardiac death and increased mortality rates in the elderly with dementia. It is recommended that whenever AAPs are used off-label, a review date is identified, informed consent is obtained and treatment and side-effects are closely monitored.

  3. Pediatricians: Kids Need 'Media Use Plan' from Parents

    Science.gov (United States)

    ... in media also can promote unhealthy eating, substance abuse and risky sexual conduct. The AAP recommends that parents prioritize creative, unplugged playtime for infants and toddlers. A child's exposure to media can start as early as ...

  4. Find a Periodontist

    Science.gov (United States)

    ... List Record CE Credits Continuing Education Opportunities Publications Journal of Periodontology JOP Online How to Subscribe Missing-Issue Claim Form Back-Issue Order Form JOP Editors Submit Manuscript Clinical Advances in Perio CAP Editors AAP Clinical and ...

  5. American Academy of Periodontology

    Science.gov (United States)

    ... List Record CE Credits Continuing Education Opportunities Publications Journal of Periodontology JOP Online How to Subscribe Missing-Issue Claim Form Back-Issue Order Form JOP Editors Submit Manuscript Clinical Advances in Perio CAP Editors AAP Clinical and ...

  6. Crying Baby: What to Do When Your Newborn Cries

    Science.gov (United States)

    ... Sept. 3, 2015. Welcome to the world of parenting! American Academy of Pediatrics. http://patiented.solutions.aap. ... policy Advertising and sponsorship opportunities Reprint Permissions A single copy of these materials may be reprinted for ...

  7. New Dad: Tips to Help Manage Stress

    Science.gov (United States)

    ... 2008;22:56. Welcome to the world of parenting. American Academy of Pediatrics. http://patiented.solutions.aap. ... policy Advertising and sponsorship opportunities Reprint Permissions A single copy of these materials may be reprinted for ...

  8. Crying Baby? How to Keep Your Cool

    Science.gov (United States)

    ... Sept. 4, 2015. Welcome to the world of parenting! American Academy of Pediatrics. http://patiented.solutions.aap. ... policy Advertising and sponsorship opportunities Reprint Permissions A single copy of these materials may be reprinted for ...

  9. Corrected Age for Preemies

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Ages & Stages Prenatal Baby Bathing & Skin Care Breastfeeding Crying & ... Listen Español Text Size Email Print Share Corrected Age For Preemies Page Content Article Body If your ...

  10. Ages and Stages: Teen

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Ages & Stages Prenatal Baby Toddler Preschool Gradeschool Teen Dating & ... Safety School Substance Abuse Young Adult Healthy Children > Ages & Stages > Teen Teen Article Body Adolescence can be ...

  11. The combination effects of acetaminophen and N-acetylcysteine on cytokines production and NF-κB activation of lipopolysaccharide-challenged piglet mononuclear phagocytes in vitro and in vivo.

    Science.gov (United States)

    Qiu, Yinsheng; Zhang, Jiawei; Liu, Yu; Ma, Hongwei; Cao, Fangyuan; Xu, Jun; Hou, Yongqing; Xu, Lingyun

    2013-04-15

    Lipopolysaccharide (LPS) is a known activator of mononuclear phagocytes. LPS activates the pro-inflammatory gene expression and induces the release of mediators/cytokines by TLR4-NF-κB signaling pathway. The purpose of this study was to investigate the effects of acetaminophen (AAP) and N-acetylcysteine (NAC), individually as well as in combination on LPS-induced cytokines production and NF-κB activation in piglets. AAP (0.125-1.0mM) and NAC (0.0625-1.0mM) down-regulate the expression of cytokines and inhibit NF-κB p65 protein transfer from the cytoplasm to the nucleus in vitro. NAC enhances the inhibition action of AAP on cytokines expression in vitro. IL-6 in piglet plasma of the AAP group (mixed feed concentration of 600 mg/kg) was significantly reduced (Ppiglet plasma of the NAC group (mixed feeding concentration of 1200 mg/kg) were significantly lower at 3h after LPS stimulation (Ppiglet plasma of AAP (mixed feed concentration of 600 mg/kg) plus NAC (mixed feeding concentration of 1200 mg/kg) group were significantly lower (P<0.05) at 3h after LPS activation. The level of IL-10 in the group with AAP plus NAC was significantly lower (P<0.05) at 24h after LPS stimulation, while the rest of the inflammatory cytokines were returned to the original levels. The NF-κB p65 concentration ratio had significantly reduced (P<0.05) when AAP and NAC were used in combination. In summary, NAC could enhance the anti-inflammatory effects of AAP both in vitro and in vivo.

  12. Protective effects of an ethanol extract of Angelica keiskei against acetaminophen-induced hepatotoxicity in HepG2 and HepaRG cells

    Science.gov (United States)

    Choi, Yoon-Hee; Lee, Hyun Sook; Chung, Cha-Kwon

    2017-01-01

    BACKGROUND/OBJECTIVE Although Angelica keiskei (AK) has widely been utilized for the purpose of general health improvement among Asian, its functionality and mechanism of action. The aim of this study was to determine the protective effect of ethanol extract of AK (AK-Ex) on acute hepatotoxicity induced by acetaminophen (AAP) in HepG2 human hepatocellular liver carcinoma cells and HepaRG human hepatic progenitor cells. MATERIALS/METHODS AK-Ex was prepared HepG2 and HepaRG cells were cultured with various concentrations and 30 mM AAP. The protective effects of AK-Ex against AAP-induced hepatotoxicity in HepG2 and HepaRG cells were evaluated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide, lactate dehydrogenase (LDH) assay, flow cytometry, and Western blotting. RESULTS AK-Ex, when administered prior to AAP, increased cell growth and decreased leakage of LDH in a dose-dependent manner in HepG2 and HepaRG cells against AAP-induced hepatotoxicity. AK-Ex increased the level of Bcl-2 and decreased the levels of Bax, Bok and Bik decreased the permeability of the mitochondrial membrane in HepG2 cells intoxicated with AAP. AK-Ex decreased the cleavage of poly (ADP-ribose) polymerase (PARP) and the activation of caspase-9, -7, and -3. CONCLUSIONS These results demonstrate that AK-Ex downregulates apoptosis via intrinsic and extrinsic pathways against AAP-induced hepatotoxicity. We suggest that AK could be a useful preventive agent against AAP-induced apoptosis in hepatocytes.

  13. Evaluation of Prevalence, Homology and Immunogenicity of Dispersin among Enteroaggregative Escherichia coli Isolates from Iran

    OpenAIRE

    Karam, Mohammad Reza Asadi; Rezaei, Ali Akbar; Siadat, Seyed Davar; Habibi, Mehri; Bouzari, Saeid

    2017-01-01

    Background: Diarrhea, caused by enteroaggregative Escherichia coli (EAEC), is an important infection leading toillness and death. Numerous virulent factors have been described in EAEC. However, their prevalence was highly variable among EAECs of distinct geographic locations. Studies have shown that dispersin (antiaggregation protein, aap) is one of the important and abundant virulent factors in EAEC. In this study, we aimed to determine the presence, conservation, and immunogenicity of aap g...

  14. Abundance and genetic diversity of aerobic anoxygenic phototrophic bacteria of coastal regions of the pacific ocean.

    Science.gov (United States)

    Ritchie, Anna E; Johnson, Zackary I

    2012-04-01

    Aerobic anoxygenic phototrophic (AAP) bacteria are photoheterotrophic microbes that are found in a broad range of aquatic environments. Although potentially significant to the microbial ecology and biogeochemistry of marine ecosystems, their abundance and genetic diversity and the environmental variables that regulate these properties are poorly understood. Using samples along nearshore/offshore transects from five disparate islands in the Pacific Ocean (Oahu, Molokai, Futuna, Aniwa, and Lord Howe) and off California, we show that AAP bacteria, as quantified by the pufM gene biomarker, are most abundant near shore and in areas with high chlorophyll or Synechococcus abundance. These AAP bacterial populations are genetically diverse, with most members belonging to the alpha- or gammaproteobacterial groups and with subclades that are associated with specific environmental variables. The genetic diversity of AAP bacteria is structured along the nearshore/offshore transects in relation to environmental variables, and uncultured pufM gene libraries suggest that nearshore communities are distinct from those offshore. AAP bacterial communities are also genetically distinct between islands, such that the stations that are most distantly separated are the most genetically distinct. Together, these results demonstrate that environmental variables regulate both the abundance and diversity of AAP bacteria but that endemism may also be a contributing factor in structuring these communities.

  15. Determination of 2-Aminoacetophenone in wine by high-performance thin-layer chromatography-fluorescence detection.

    Science.gov (United States)

    Horlacher, Nora; Schwack, Wolfgang

    2016-02-01

    2-Aminoacetophenone (AAP) is closely correlated with the appearance of the sensory phenomenon of UTA ("untypical aging off-flavor") in wine. AAP analyses are generally performed by gas chromatography and mass selective detection (GC/MS), when AAP is extracted from wines by liquid-liquid, solid-liquid or solid phase microextraction. Here we present a rapid, selective and sensitive method for the determination of AAP in wine by high-performance thin-layer chromatography with fluorescence detection (HPTLC-FLD). As internal standard, 2-amino-4-methoxyacetophenone was used. Liquid-liquid extraction with t-butyl methyl ether was followed by a basic cleanup of the extracts, which were applied onto HPTLC amino plates developed with methylene chloride/toluene (7+3, v/v) as mobile phase. Dipping the dried plate into hexane-paraffin solution enhanced fluorescence that was scanned at 366/>400nm. Limits of detection and quantitation were determined to be 0.1 and 0.3μgL(-1) wine, respectively, while only AAP concentrations >0.5μgL(-1) result in UTA. Recoveries were near 100% for model, white, rosé and red wines. Thus, the HPTLC-FLD method enables the analysis of AAP in wines clearly below the odor thresholds and represents a rapid and convenient screening alternative to existing GC/MS methods.

  16. Improved Anticancer Photothermal Therapy Using the Bystander Effect Enhanced by Antiarrhythmic Peptide Conjugated Dopamine-Modified Reduced Graphene Oxide Nanocomposite.

    Science.gov (United States)

    Yu, Jiantao; Lin, Yu-Hsin; Yang, Lingyan; Huang, Chih-Ching; Chen, Liliang; Wang, Wen-Cheng; Chen, Guan-Wen; Yan, Junyan; Sawettanun, Saranta; Lin, Chia-Hua

    2017-01-01

    Despite tremendous efforts toward developing novel near-infrared (NIR)-absorbing nanomaterials, improvement in therapeutic efficiency remains a formidable challenge in photothermal cancer therapy. This study aims to synthesize a specific peptide conjugated polydopamine-modified reduced graphene oxide (pDA/rGO) nanocomposite that promotes the bystander effect to facilitate cancer treatment using NIR-activated photothermal therapy. To prepare a nanoplatform capable of promoting the bystander effect in cancer cells, we immobilized antiarrhythmic peptide 10 (AAP10) on the surface of dopamine-modified rGO (AAP10-pDA/rGO). Our AAP10-pDA/rGO could promote the bystander effect by increasing the expression of connexin 43 protein in MCF-7 breast-cancer cells. Because of its tremendous ability to absorb NIR absorption, AAP10-pDA/rGO offers a high photothermal effect under NIR irradiation. This leads to a massive death of MCF-7 cells via the bystander effect. Using tumor-bearing mice as the model, it is found that NIR radiation effectively ablates breast tumor in the presence of AAP10-pDA/rGO and inhibits tumor growth by ≈100%. Therefore, this research integrates the bystander and photothermal effects into a single nanoplatform in order to facilitate an efficient photothermal therapy. Furthermore, our AAP10-pDA/rGO, which exhibits both hyperthermia and the bystander effect, can prevent breast-cancer recurrence and, therefore, has great potential for future clinical and research applications.

  17. Korean Medication Algorithm Project for Bipolar Disorder: third revision

    Directory of Open Access Journals (Sweden)

    Woo YS

    2015-02-01

    Full Text Available Young Sup Woo,1 Jung Goo Lee,2,3 Jong-Hyun Jeong,1 Moon-Doo Kim,4 Inki Sohn,5 Se-Hoon Shim,6 Duk-In Jon,7 Jeong Seok Seo,8 Young-Chul Shin,9 Kyung Joon Min,10 Bo-Hyun Yoon,11 Won-Myong Bahk1 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 2Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, South Korea;3Paik Institute for Clinical Research, Inje Univeristy, Busan, South Korea; 4Department of Psychiatry, Jeju National University Hospital, Jeju, South Korea; 5Department of Psychiatry, Keyo Hospital, Keyo Medical Foundation, Uiwang, South Korea; 6Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Soonchunhyang University, Cheonan, South Korea; 7Department of Psychiatry, Sacred Heart Hospital, Hallym University, Anyang, South Korea; 8Department of Psychiatry, School of Medicine, Konkuk University, Chungju, South Korea; 9Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, South Korea; 10Department of Psychiatry, College of Medicine, Chung-Ang University, Seoul, South Korea; 11Department of Psychiatry, Naju National Hospital, Naju, South Korea Objective: To constitute the third revision of the guidelines for the treatment of bipolar disorder issued by the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP 2014. Methods: A 56-item questionnaire was used to obtain the consensus of experts regarding pharmacological treatment strategies for the various phases of bipolar disorder and for special populations. The review committee included 110 Korean psychiatrists and 38 experts for child and adolescent psychiatry. Of the committee members, 64 general psychiatrists and 23 child and adolescent psychiatrists responded to the survey. Results: The treatment of choice (TOC for euphoric, mixed, and psychotic mania was the combination of a mood stabilizer (MS and an atypical antipsychotic (AAP; the TOC for

  18. Transformation of acetaminophen during water chlorination treatment: kinetics and transformation products identification.

    Science.gov (United States)

    Cao, Fei; Zhang, Mengtao; Yuan, Shoujun; Feng, Jingwei; Wang, Qiquan; Wang, Wei; Hu, Zhenhu

    2016-06-01

    As a high-consumption drug in the world, acetaminophen (AAP) has been widely detected in natural waters and wastewaters. Its reactivity and the transformation products formed during chlorination may greatly threaten the safety of drinking water. The reaction kinetics of AAP during chlorination was investigated in this study. The results showed that the reaction kinetics could be well described with a kinetics model of -d[AAP]/dt = k app[AAP]t (0.63)[Cl2]t (1.37). The values of apparent rate constant (k app) were dependent on reaction temperature, ammonium, and pH. With the increase in reaction temperature from 5.0 ± 1.0 to 40.0 ± 1.0 °C, the removal efficiency of AAP increased from 60 to 100 %. When ammonium was present in the solution at 2.0 mg/L, the transformation of AAP was inhibited due to the rapid formation of chloramines. The maximum of k app was 0.58 × 10(2) M(-1) · min(-1) at pH 9.0, and the minimum was 0.27 M(-1) · min(-1) at pH 11.0. A low mineralization of AAP (about 7.2 %) with chlorination was observed through TOC analysis, implying the formation of plenty of transformation products during chlorination. The main transformation products, hydroquinone and two kinds of chlorinated compounds, monochlorinated acetaminophen and dichlorinated acetaminophen, were detected in gas chromatography-mass spectrometry analysis.

  19. Advanced Avionics and Processor Systems for a Flexible Space Exploration Architecture

    Science.gov (United States)

    Keys, Andrew S.; Adams, James H.; Smith, Leigh M.; Johnson, Michael A.; Cressler, John D.

    2010-01-01

    The Advanced Avionics and Processor Systems (AAPS) project, formerly known as the Radiation Hardened Electronics for Space Environments (RHESE) project, endeavors to develop advanced avionic and processor technologies anticipated to be used by NASA s currently evolving space exploration architectures. The AAPS project is a part of the Exploration Technology Development Program, which funds an entire suite of technologies that are aimed at enabling NASA s ability to explore beyond low earth orbit. NASA s Marshall Space Flight Center (MSFC) manages the AAPS project. AAPS uses a broad-scoped approach to developing avionic and processor systems. Investment areas include advanced electronic designs and technologies capable of providing environmental hardness, reconfigurable computing techniques, software tools for radiation effects assessment, and radiation environment modeling tools. Near-term emphasis within the multiple AAPS tasks focuses on developing prototype components using semiconductor processes and materials (such as Silicon-Germanium (SiGe)) to enhance a device s tolerance to radiation events and low temperature environments. As the SiGe technology will culminate in a delivered prototype this fiscal year, the project emphasis shifts its focus to developing low-power, high efficiency total processor hardening techniques. In addition to processor development, the project endeavors to demonstrate techniques applicable to reconfigurable computing and partially reconfigurable Field Programmable Gate Arrays (FPGAs). This capability enables avionic architectures the ability to develop FPGA-based, radiation tolerant processor boards that can serve in multiple physical locations throughout the spacecraft and perform multiple functions during the course of the mission. The individual tasks that comprise AAPS are diverse, yet united in the common endeavor to develop electronics capable of operating within the harsh environment of space. Specifically, the AAPS tasks for

  20. Atypical antipsychotics in the treatment of early-onset schizophrenia

    Directory of Open Access Journals (Sweden)

    Hrdlicka M

    2015-04-01

    Full Text Available Michal Hrdlicka, Iva Dudova Department of Child Psychiatry, Charles University Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic Abstract: Atypical antipsychotics (AAPs have been successfully used in early-onset schizophrenia (EOS. This review summarizes the randomized, double-blind, controlled studies of AAPs in EOS, including clozapine, risperidone, olanzapine, aripiprazole, paliperidone, quetiapine, and ziprasidone. No significant differences in efficacy between AAPs were found, with the exception of clozapine and ziprasidone. Clozapine demonstrated superior efficacy in treatment-resistant patients with EOS, whereas ziprasidone failed to demonstrate efficacy in the treatment of EOS. Our review also focuses on the onset of action and weight gain associated with AAPs. The data on onset of action of AAPs in pediatric psychiatry are scanty and inconsistent. Olanzapine appears to cause the most significant weight gain in patients with EOS, while ziprasidone and aripiprazole seem to cause the least. Keywords: early-onset schizophrenia, atypical antipsychotics, efficacy, onset of action, weight gain

  1. Photoheterotrophic microbes in the Arctic Ocean in summer and winter.

    Science.gov (United States)

    Cottrell, Matthew T; Kirchman, David L

    2009-08-01

    Photoheterotrophic microbes, which are capable of utilizing dissolved organic materials and harvesting light energy, include coccoid cyanobacteria (Synechococcus and Prochlorococcus), aerobic anoxygenic phototrophic (AAP) bacteria, and proteorhodopsin (PR)-containing bacteria. Our knowledge of photoheterotrophic microbes is largely incomplete, especially for high-latitude waters such as the Arctic Ocean, where photoheterotrophs may have special ecological relationships and distinct biogeochemical impacts due to extremes in day length and seasonal ice cover. These microbes were examined by epifluorescence microscopy, flow cytometry, and quantitative PCR (QPCR) assays for PR and a gene diagnostic of AAP bacteria (pufM). The abundance of AAP bacteria and PR-containing bacteria decreased from summer to winter, in parallel with a threefold decrease in the total prokaryotic community. In contrast, the abundance of Synechococcus organisms did not decrease in winter, suggesting that their growth was supported by organic substrates. Results from QPCR assays revealed no substantial shifts in the community structure of AAP bacteria and PR-containing bacteria. However, Arctic PR genes were different from those found at lower latitudes, and surprisingly, they were not similar to those in Antarctic coastal waters. Photoheterotrophic microbes appear to compete successfully with strict heterotrophs during winter darkness below the ice, but AAP bacteria and PR-containing bacteria do not behave as superior competitors during the summer.

  2. Phylogenetically Diverse Aerobic Anoxygenic Phototrophic Bacteria Isolated from Epilithic Biofilms in Tama River, Japan

    Science.gov (United States)

    Hirose, Setsuko; Matsuura, Katsumi; Haruta, Shin

    2016-01-01

    The diversity of aerobic anoxygenic phototrophic (AAP) bacteria in freshwater environments, particularly in rivers, has not been examined in as much detail as in ocean environments. In the present study, we investigated the phylogenetic and physiological diversities of AAP bacteria in biofilms that developed on submerged stones in a freshwater river using culture methods. The biofilms collected were homogenized and inoculated on solid media and incubated aerobically in the dark. Sixty-eight red-, pink-, yellow-, orange-, or brown-colored colonies were isolated, and, of these, 28 isolates contained the photosynthetic pigment, bacteriochlorophyll (BChl) a. Phylogenetic analyses based on 16S rRNA gene sequences showed that the isolates were classified into 14 groups in 8 operational taxonomic units (OTUs) and distributed in the orders Rhodospirillales, Rhodobacterales, and Sphingomonadales of Alphaproteobacteria and in Betaproteobacteria. Physiological analyses confirmed that none of the representative isolates from any of the groups grew under anaerobic phototrophic conditions. Seven isolates in 4 OTUs showed a 16S rRNA gene sequence identity of 98.0% or less with any established species, suggesting the presence of previously undescribed species of AAP bacteria. Six isolates in 2 other OTUs had the closest relatives, which have not been reported to be AAP bacteria. Physiological comparisons among the isolates revealed differences in preferences for nutrient concentrations, BChl contents, and light-harvesting proteins. These results suggest that diverse and previously unknown AAP bacteria inhabit river biofilms. PMID:27453124

  3. Asparaginase-associated pancreatitis

    DEFF Research Database (Denmark)

    Wolthers, B O; Frandsen, T L; Abrahamsson, J;

    2016-01-01

    Asparaginase (ASP)-associated pancreatitis (AAP) occurs during acute lymphoblastic leukemia treatment. Among 1285 children (1.0-17.9 years) diagnosed during July 2008-December 2014 and treated according to the Nordic/Baltic ALL2008 protocol, 86 (cumulative incidence=6.8%) developed AAP. Seventy...... therapy, and 7% had recurrent abdominal pain. Germline DNA on 62 cases and 638 controls was genotyped on Omni2.5exome-8-v1.2 BeadChip arrays. Overall, the ULK2 variant rs281366 showed the strongest association with AAP (P=5.8 × 10(-7); odds ratio (OR)=6.7). Cases with the rs281366 variant were younger (4.......3 vs 8 years; P=0.015) and had lower risk of AAP-related complications (15% vs 43%; P=0.13) compared with cases without this variant. Among 45 cases and 517 controls associations with AAP were found for RGS6 variant rs17179470 (P=9.8 × 10(-9); OR=7.3). Rs281366 is located...

  4. Novel Spectrophotometric Method for Determination of Macro-paracetamol via Reaction with Bromine

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    The reaction between Br2 and paracetamol(p-AAP) leads to the formation of a coloured product, which can be used for spectrophotometric determination of the p-AAP content in its pure form and in different pharmaceutical preparations with p-AAP. The stoichiometric composition of the reaction was found to be n(p-AAP)∶n(bromine)=1∶3. The effects of pH and time on the spectra of p-AAP-bromine redox reaction product were studied. The interference of different additives on the measured spectra of the obtained product was also studied. The results obtained by the present method were compared with those obtained by the standard method. The F- and t- test values were calculated for both of the applied procedures and they met a confidence level of 99%. The proposed procedure actually needs no separation of these drugs from their sources before analysis and was unaffected by interference of other phenolic compounds. The proposed method is simpler and faster than the repoeted ones.

  5. Comparative release studies on suppositories using the basket, paddle, dialysis tubing and flow-through cell methods I. Acetaminophen in a lipophilic base suppository.

    Science.gov (United States)

    Hori, Seiichi; Kawada, Tsubasa; Kogure, Sanae; Yabu, Shinako; Mori, Kenji; Akimoto, Masayuki

    2017-02-01

    The release characteristics of lipophilic suppositories containing acetaminophen (AAP) were examined using four types of dissolution methods: the basket, paddle, dialysis tubing (DT) and flow-through cell (FTC) methods. The suitability of each apparatus for quality control in AAP compounded suppositories was evaluated using statistical procedures. More than 80% of the drug was released over 60 min in all the release methods studied, with the exception of the basket method. Reproducible and faster release was achieved using the paddle method at 100 and 200 rpm, whereas poor release occurred with the basket method. The mean dissolution time (MDT), maximum dissolved quantity of AAP at the end of the sampling time (Q) and dissolution efficiency (DE) were calculated by model-independent methods. The FTC method with a single chamber used in this study was also appreciable for AAP suppositories (Q of 100%, MDT of 71-91 min and DE of 75-80%). The DT apparatus is considered similar to the FTC apparatus from a quality control perspective for judging the release properties of lipophilic base suppositories containing AAP. However, even the single chamber FTC used in this study has potential as an in vitro drug release test for suppositories. The comparative dissolution method is expected to become one of the valuable tools for selecting an adequate dissolution test.

  6. Diversity of the aerobic anoxygenic phototrophy genepufM in Arctic and Antarctic coastal seawaters

    Institute of Scientific and Technical Information of China (English)

    ZENG Yinxin; DONG Peiyan; QIAO Zongyun; ZHENG Tianling

    2016-01-01

    Aerobic anoxygenic phototrophic (AAP) bacteria serve important functions in marine carbon and energy cycling because of their capability to utilize dissolved organic substrates and harvest light energy. AAP bacteria are widely distributed in marine environments, and their diversity has been examined in marine habitats. However, information about AAP bacteria at high latitudes remains insufficient to date. Therefore, this study determined the summer AAP bacterial diversity in Arctic Kongsfjorden and in the Antarctic coastal seawater of King George Island on the basis ofpufM, a gene that encodes a pigment-binding protein subunit of the reaction center complex. FourpufM clone libraries were constructed, and 674 positive clones were obtained from four investigated stations (two in Kongsfjorden and two in the Antarctic Maxwell Bay). Arctic clones were clustered within theAlphaproteobacteria, whereas Antarctic clones were classified into theAlphaproteobacteria and Betaproteobacteria classes.Rhodobacteraceae-likepufM genes dominated in all samples. In addition, sequences closely related topufM encoded on a plasmid inSulfitobacter guttiformis were predominant in both Arctic and Antarctic samples. This result indicates the transpolar or even global distribution ofpufM genes in marine environments. Meanwhile, differences between the Arctic and Antarctic sequences may prove polar endemism. These results indicate the important role ofRhodobacteraceae as AAP bacteria in bipolar coastal waters.

  7. Ssh4, Rcr2 and Rcr1 affect plasma membrane transporter activity in Saccharomyces cerevisiae.

    Science.gov (United States)

    Kota, Jhansi; Melin-Larsson, Monika; Ljungdahl, Per O; Forsberg, Hanna

    2007-04-01

    Nutrient uptake in the yeast Saccharomyces cerevisiae is a highly regulated process. Cells adjust levels of nutrient transporters within the plasma membrane at multiple stages of the secretory and endosomal pathways. In the absence of the ER-membrane-localized chaperone Shr3, amino acid permeases (AAP) inefficiently fold and are largely retained in the ER. Consequently, shr3 null mutants exhibit greatly reduced rates of amino acid uptake due to lower levels of AAPs in their plasma membranes. To further our understanding of mechanisms affecting AAP localization, we identified SSH4 and RCR2 as high-copy suppressors of shr3 null mutations. The overexpression of SSH4, RCR2, or the RCR2 homolog RCR1 increases steady-state AAP levels, whereas the genetic inactivation of these genes reduces steady-state AAP levels. Additionally, the overexpression of any of these suppressor genes exerts a positive effect on phosphate and uracil uptake systems. Ssh4 and Rcr2 primarily localize to structures associated with the vacuole; however, Rcr2 also localizes to endosome-like vesicles. Our findings are consistent with a model in which Ssh4, Rcr2, and presumably Rcr1, function within the endosome-vacuole trafficking pathway, where they affect events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane.

  8. Lawrence Berkeley Laboratory Affirmative Action Program. Revised

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    The Lawrence Berkeley Laboratory`s Affirmative Action Program (AAP) serves as a working document that describes current policies, practices, and results in the area of affirmative action. It represents the Laboratory`s framework for an affirmative approach to increasing the representation of people of color and women in segments of our work force where they have been underrepresented and taking action to increase the employment of persons with disabilities and special disabled and Vietnam era veterans. The AAP describes the hierarchy of responsibility for Laboratory affirmative action, the mechanisms that exist for full Laboratory participation in the AAP, the policies and procedures governing recruitment at all levels, the Laboratory`s plan for monitoring, reporting, and evaluating affirmative action progress, and a description of special affirmative action programs and plans the Laboratory has used and will use in its efforts to increase the representation and retention of groups historically underrepresented in our work force.

  9. Serial Ultrasound Monitoring for Early Recognition of Asparaginase Associated Pancreatitis in Children With Acute Lymphoblastic Leukemia

    DEFF Research Database (Denmark)

    Raja, Raheel Altaf; Schmiegelow, K.; Henriksen, Birthe Merete;

    2015-01-01

    BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common cancer in children and L-asparaginase is an essential component of the treatment. Cessation of L-asparaginase decreases event free survival. Acute pancreatitis is the toxicity that most commonly results in cessation of L...... protocol, with PEG-asparaginase of 2 or 6 week intervals, for 30 weeks had their pancreas monitored using serial ultrasound in order to detect early signs of inflammation. RESULTS: Nineteen of 31 eligible patients were included. Three of the included patients developed AAP. None of the patients, including...... the three patients that developed AAP, had signs of inflammatory edema or pancreas enzymes above three times the upper normal limit prior to AAP. CONCLUSION: We found no signs of inflammatory edema within the pancreas on ultrasound during treatment with PEG-asparginase in our cohort prior to development...

  10. Nurses' Knowledge and Adherence To Sudden Infant Death Syndrome Prevention Guidelines.

    Science.gov (United States)

    Bartlow, Kendra L; Cartwright, Sara B; Shefferly, Erin K

    2016-01-01

    The American Academy of Pediatrics (AAP) defines standard guidelines for infant positioning and sleep environment to reduce the rate of sudden infant death syndrome (SIDS), but recent data on nurses' knowledge and adherence to these guidelines in hospital settings are limited. An observational, quantitative, and descriptive study was conducted on well-baby postpartum nurseries at two urban Washington, DC, hospitals. Sixty-six direct observations of infant position and crib environment were conducted, and a 17-question survey was administered to determine nurses' knowledge and practice regarding AAP SIDS prevention guidelines. Of observed sleeping conditions, 69.7% failed the guidelines for infant positioning, crib environment, or both, despite nurses' reporting knowledge of the AAP guidelines. Further research is needed to determine if the study's findings are consistent with hospitals elsewhere, and to better understand the disconnect between nurses' knowledge and behavior regarding SIDS prevention guidelines.

  11. Structural, thermal, morphological and biological studies of proton-transfer complexes formed from 4-aminoantipyrine with quinol and picric acid.

    Science.gov (United States)

    Adam, Abdel Majid A

    2013-03-01

    4-Aminoantipyrine (4AAP) is widely used in the pharmaceutical industry, biochemical experiments and environmental monitoring. However, residual amounts of 4AAP in the environment may pose a threat to human health. To provide basic data that can be used to extract or eliminate 4AAP from the environment, the proton-transfer complexes of 4AAP with quinol (QL) and picric acid (PA) were synthesized and spectroscopically investigated. The interactions afforded two new proton-transfer salts named 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-aminium-4-hydroxyphenolate and 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-aminium-2,4,6-trinitrophenolate for QL and PA, respectively, via a 1:1 stoichiometry. Elemental analysis (CHN), electronic absorption, spectrophotometric titration, IR, Raman, (1)H NMR and X-ray diffraction were used to characterize the new products. The thermal stability of the synthesized CT complexes was investigated using thermogravimetric (TG) analyses, and the morphology and particle size of these complexes were obtained from scanning electron microscopy (SEM). It was found that PA and 4AAP immediately formed a yellow precipitate with a remarkable sponge-like morphology and good thermal stability up to 180°C. Finally, the biological activities of the newly synthesized CT complexes were tested for their antibacterial and antifungal activities. The results indicated that the [(4AAP)(QL)] complex exhibited strong antimicrobial activities against various bacterial and fungal strains compared with standard drugs.

  12. Pro-oxidant status and matrix metalloproteinases in apical lesions and gingival crevicular fluid as potential biomarkers for asymptomatic apical periodontitis and endodontic treatment response

    Directory of Open Access Journals (Sweden)

    Dezerega Andrea

    2012-03-01

    Full Text Available Abstract Background Oxidative stress and matrix metalloproteinases -9 and -2 are involved in periodontal breakdown, whereas gingival crevicular fluid has been reported to reflect apical status. The aim of this study was to characterize oxidant balance and activity levels of MMP -2 and -9 in apical lesions and healthy periodontal ligament; and second, to determine whether potential changes in oxidant balance were reflected in gingival crevicular fluid from asymptomatic apical periodontitis (AAP-affected teeth at baseline and after endodontic treatment. Methods Patients with clinical diagnosis of AAP and healthy volunteers having indication of tooth extraction were recruited. Apical lesions and healthy periodontal ligaments, respectively, were homogenized or processed to obtain histological tissue sections. Matrix metalloproteinase -9 and -2 levels and/or activity were analyzed by Immunowestern blot, zymography and consecutive densitometric analysis, and their tissue localization was confirmed by immunohistochemistry. A second group of patients with AAP and indication of endodontic treatment was recruited. Gingival crevicular fluid was extracted from AAP-affected teeth at baseline, after endodontic treatment and healthy contralateral teeth. Total oxidant and antioxidant status were determined in homogenized tissue and GCF samples. Statistical analysis was performed using STATA v10 software with unpaired t test, Mann-Whitney test and Spearman's correlation. Results Activity of MMP-2 and MMP-9 along with oxidant status were higher in apical lesions (p Conclusions Apical lesions display an oxidant imbalance along with increased activity of matrix metalloproteinase-2 and -9 and might contribute to AAP progression. Oxidant imbalance can also be reflected in GCF from AAP-affected teeth and was restored to normal levels after conservative endodontic treatment. These mediators might be useful as potential biomarkers for chair-side complementary diagnostic

  13. Effects of antiarrhythmic peptide 10 on acute ventricular arrhythmia

    Institute of Scientific and Technical Information of China (English)

    Bing Sun; Jin-Fa Jiang; Cui-Mei Zhao; Chao-Hui Hu

    2015-01-01

    Objective:To observe the effects antiarrhythmic peptide 10 (AAP10) aon acute ventricular arrhythmia and the phosphorylation state of ischemic myocardium connexin.Methods:Acute total ischemia and partial ischemia models were established by ceasing perfusion and ligating the left anterior descending coronary artery in SD rats. The effects of AAP10 (1 mg/L) on the incidence rate of ischemia-induced ventricular arrhythmia were observed. The ischemic myocardium was sampled to detect total-Cx43 and NP-Cx43 by immunofluorescent staining and western blotting. the total-Cx43 expression was detected through image analysis system by semi-quantitative analysis.Results: AAP10 could significantly decrease the incidence of ischemia-induced ventricular tachycardia and ventricular fibrillation. During ischemic stage, total ischemia (TI) and AAP10 total ischemia (ATI) groups were compared with partial ischemia (PI) and AAP10 partial ischemia (API) groups. The rates of incidence for arrhythmia in the ATI and API groups (10% and 0%) were lower than those in the TI and PI groups (60% and 45%). The difference between the two groups was statistically significant (P=0.019, P=0.020). The semi-quantitative analysis results of the ischemic myocardium showed that the total-Cx43 protein expression distribution areas for TI, ATI, PI and API groups were significantly decreased compared with the control group. On the other hand, the NP-Cx43 distribution areas of TI, ATI, PI and API groups were significantly increased compared with the control group (P>0.05). AAP10 could increase the total-Cx43 expression in the ischemic area and decrease the NP-Cx43 expression. Western blot results were consistent with the results of immunofluorescence staining.Conclusions:AAP10 can significantly decrease the rate of incidence of acute ischemia-induced ventricular tachycardia and ventricular fibrillation. Acute ischemic ventricular arrhythmias may have a relationship with the decreased phosphorylation of Cx43

  14. Dicty_cDB: Contig-U07086-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available al-Ocean-Sampling_GS-31-01-01-1... 44 5.5 1 ( DY272854 ) IC0AAA32BC06RM1 CitNFL Citrus clementina cDNA 5',...... 44 5.5 1 ( DY271159 ) KN0AAP9YA15FM1 Fruit-TF Citrus clementina cDNA 5'... 44 5.5 1 ( DY259793 ) KN0AAP10Y...D11FM1 Fruit-TF Citrus clementina cDNA 5... 44 5.5 1 ( CV710938 ) UCRPT01_0015C02

  15. Efficiency and patient experience with propofol vsconventional sedation: A prospective study

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    AIM To determine whether anaesthesiologistadministeredsedation with propofol (AAP) or endoscopist-administered conscious sedation (EAC) withfentanyl/midazolam shortens colonoscopy duration/totalroom time.METHODS: This is a prospective, non-randomized,comparative study that enrolled patients greater than18 years of age undergoing colonoscopy in a singleCanadian academic outpatient endoscopy unit over athree-month consecutive period. Colonoscopies in thisunit are performed both with AAP and EAC. Patientdemographics, procedure-related data and adverseevents were documented. Additionally, the level ofprocedure difficulty, and whether a staff endoscopist,trainee with assistance, or independent trainee, performedthe procedure were documented. A validatedmodified 4-question, 5-point Likert scale telephonesurvey was used to assess patient satisfaction withcolonoscopy. The telephone patient satisfaction surveywas conducted 24-72 h following the procedure.RESULTS: Two hundred and thirty patients were enrolled during the study period with 126 patients inthe AAP group and 104 patients in the EAC group.Mean procedure time was 18.3 ± 10.1 min in theAAP group and 14.7 ± 7.1 min in the EAC group (P =0.002). Mean total room time was 36.8 ± 13.7 with AAPand 30.1 ± 11 min with EAC (p 〈 0.001). Multivariateanalysis revealed the use of AAP (P = 0.002), residentparticipation (p 〈 0.001), diagnostic interventions (p= 0.033), therapeutic interventions (p 〈 0.001), lowerbody mass index (p = 0.008) and American Society ofAnaesthesiologist class (p = 0.016), to be predictorsof longer total room time. Patient age and genderwere not significant predictors. After excluding cases inwhich trainees were involved, there was no significantdifference in procedure time between the two groups (p= 0.941), however total room time was still prolongedin the AAP group (p = 0.019). The amount of painexperienced was lower with AAP (p = 0.02

  16. Reference: 411 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available id permease (AAP) subfamily genes are preferentially expressed in the vascular tissue, suggesting roles in l...ter LYSINE HISTIDINE TRANSPORTER1 (LHT1), an AAP homolog, is expressed in both th...en sources because of the severe inhibition of amino acid uptake from the medium, and uptake of amino acids ...into mesophyll protoplasts is inhibited. Interestingly, lht1 mutants, which show ...growth defects on fertilized soil, can be rescued when LHT1 is reexpressed in green tissue. These findings are

  17. Precipitation estimation in mountainous terrain using multivariate geostatistics. Part II: isohyetal maps

    Science.gov (United States)

    Hevesi, Joseph A.; Flint, Alan L.; Istok, Jonathan D.

    1992-01-01

    Values of average annual precipitation (AAP) may be important for hydrologic characterization of a potential high-level nuclear-waste repository site at Yucca Mountain, Nevada. Reliable measurements of AAP are sparse in the vicinity of Yucca Mountain, and estimates of AAP were needed for an isohyetal mapping over a 2600-square-mile watershed containing Yucca Mountain. Estimates were obtained with a multivariate geostatistical model developed using AAP and elevation data from a network of 42 precipitation stations in southern Nevada and southeastern California. An additional 1531 elevations were obtained to improve estimation accuracy. Isohyets representing estimates obtained using univariate geostatistics (kriging) defined a smooth and continuous surface. Isohyets representing estimates obtained using multivariate geostatistics (cokriging) defined an irregular surface that more accurately represented expected local orographic influences on AAP. Cokriging results included a maximum estimate within the study area of 335 mm at an elevation of 7400 ft, an average estimate of 157 mm for the study area, and an average estimate of 172 mm at eight locations in the vicinity of the potential repository site. Kriging estimates tended to be lower in comparison because the increased AAP expected for remote mountainous topography was not adequately represented by the available sample. Regression results between cokriging estimates and elevation were similar to regression results between measured AAP and elevation. The position of the cokriging 250-mm isohyet relative to the boundaries of pinyon pine and juniper woodlands provided indirect evidence of improved estimation accuracy because the cokriging result agreed well with investigations by others concerning the relationship between elevation, vegetation, and climate in the Great Basin. Calculated estimation variances were also mapped and compared to evaluate improvements in estimation accuracy. Cokriging estimation variances

  18. 代谢综合征孕妇血清丙氨酸氨基肽酶、亮氨酸氨基肽酶表达和临床意义%Clinical significance and expression of alanine amino peptidase and leucine amino peptidase in the serum of pregnant women with metabolic syndrome

    Institute of Scientific and Technical Information of China (English)

    蔡仲仁

    2011-01-01

    目的:探讨代谢综合征孕妇血清丙氨酸氨基肽酶(AAP)、亮氨酸氨基肽酶(LAP)水平的表达,分析其临床意义.方法:选取我院2009年1月~2010年12月收治的42例代谢综合征孕妇作为研究组,入院后检测血清AAP、LAP的表达.另外选择同期我院的40例正常孕妇作为对照组,入院后检测血清AAP、LAP的表达.所有孕妇均为妊娠晚期.结果:研究组血清AAP[(64.21±9.46)U/L]、LAP[(53.53±7.67)U/L]均高于对照组血清AAP[(44.64±8.36)U/L]、LAP[(36.75±7.86)U/L],两组比较,差异有统计学意义(P<0.05).结论:代谢综合征孕妇血清AAP、LAP明显增高,可能是机体对代谢综合征的一种保护措施.%Objective: To discuss the expression of aianine ammo peptidase (APP) and leucine amino peptidase (LAP) in the serum of pregnant women with metabolic syndrome, and analyze the clinical significance. Methods: 42 pregnant women with metabolic syndrome were collected from January 2009 to December 2010 in our hospital, after admission the serum AAP, LAP expression were detected. Another 40 patients with normal pregnant women were chose as control group, as the same time after admission the serum AAP, LAP expression were delected. All pregnant women were late trimester of pregnancy. Results: After the detection, the semm AAP [(64.21 ±9.46)U/L], LAP [(53.53-7.67)LVL] in the research group were higher than those in the control group serum AAP [(44.64 ±8.36)U/Lj, LAP[(36.75±7.86)U/L], there were significant differences in the two groups (P<0.05). Conclusion: Serum AAP, LAP of pregnant women wiih metabolic syndrome is significantly higher, which may be a protection measure for the body of the metabolic syndrome.

  19. Potential for Using Acetic Acid Plus Pear Ester Combination Lures to Monitor Codling Moth in an SIT Program

    Directory of Open Access Journals (Sweden)

    Gary J. R. Judd

    2016-11-01

    Full Text Available Studies were conducted in commercial apple orchards in British Columbia, Canada, to determine whether lures combining ethyl-(E,Z-2,4-decadienoate, pear ester (PE, with either acetic acid (AA or sex pheromone, (E,E-8,10-dodecadien-1-ol (codlemone, might improve monitoring of codling moth, Cydia pomonella (L., in an area-wide programme integrating sterile insect technology (SIT and mating disruption (MD. Catches of sterile and wild codling moths were compared in apple orchards receiving weekly delivery of sterile moths (1:1 sex ratio using white delta traps baited with either AA or PE alone, and in combination. Sterile and wild codling moths responded similarly to these kairomone lures. For each moth sex and type (sterile and wild, AA-PE lures were significantly more attractive than AA or PE alone. Bisexual catches with AA-PE lures were compared with those of commercial bisexual lures containing 3 mg of codlemone plus 3 mg of PE (Pherocon CM-DA Combo lure, Trécé Inc., Adair, OK, USA, and to catches of males with standard codlemone-loaded septa used in SIT (1 mg and MD (10 mg programmes, respectively. CM-DA lures caught the greatest number of sterile and wild male moths in orchards managed with SIT alone, or combined with MD, whereas AA-PE lures caught 2–3× more females than CM-DA lures under both management systems. Sterile to wild (S:W ratios for male versus female moths in catches with AA-PE lures were equivalent, whereas in the same orchards, male S:W ratios were significantly greater than female S:W ratios when measured with CM-DA lures. Male S:W ratios measured with CM-DA lures were similar to those with codlemone lures. CM-DA and codlemone lures appear to overestimate S:W ratios as measured by AA-PE lures, probably by attracting relatively more sterile males from long range. Using AA-PE lures to monitor codling moths in an SIT programme removes fewer functional sterile males and reduces the need for trap maintenance compared with using

  20. Potential for Using Acetic Acid Plus Pear Ester Combination Lures to Monitor Codling Moth in an SIT Program.

    Science.gov (United States)

    Judd, Gary J R

    2016-11-25

    Studies were conducted in commercial apple orchards in British Columbia, Canada, to determine whether lures combining ethyl-(E,Z)-2,4-decadienoate, pear ester (PE), with either acetic acid (AA) or sex pheromone, (E,E)-8,10-dodecadien-1-ol (codlemone), might improve monitoring of codling moth, Cydia pomonella (L.), in an area-wide programme integrating sterile insect technology (SIT) and mating disruption (MD). Catches of sterile and wild codling moths were compared in apple orchards receiving weekly delivery of sterile moths (1:1 sex ratio) using white delta traps baited with either AA or PE alone, and in combination. Sterile and wild codling moths responded similarly to these kairomone lures. For each moth sex and type (sterile and wild), AA-PE lures were significantly more attractive than AA or PE alone. Bisexual catches with AA-PE lures were compared with those of commercial bisexual lures containing 3 mg of codlemone plus 3 mg of PE (Pherocon CM-DA Combo lure, Trécé Inc., Adair, OK, USA), and to catches of males with standard codlemone-loaded septa used in SIT (1 mg) and MD (10 mg) programmes, respectively. CM-DA lures caught the greatest number of sterile and wild male moths in orchards managed with SIT alone, or combined with MD, whereas AA-PE lures caught 2-3× more females than CM-DA lures under both management systems. Sterile to wild (S:W) ratios for male versus female moths in catches with AA-PE lures were equivalent, whereas in the same orchards, male S:W ratios were significantly greater than female S:W ratios when measured with CM-DA lures. Male S:W ratios measured with CM-DA lures were similar to those with codlemone lures. CM-DA and codlemone lures appear to overestimate S:W ratios as measured by AA-PE lures, probably by attracting relatively more sterile males from long range. Using AA-PE lures to monitor codling moths in an SIT programme removes fewer functional sterile males and reduces the need for trap maintenance compared with using

  1. Student Satisfaction and Graduate Part-Time Students

    Science.gov (United States)

    Moore, Monica Moody

    2011-01-01

    The Advanced Academic Programs (AAP) of the Zanvyl Krieger School of Arts and Sciences at Johns Hopkins University (JHU) enrolls approximately 2,700 part-time graduate students across three physical locations. It is a complex organization whose target audience is a sophisticated consumer of higher education. With the support of Eduventures, AAP…

  2. Membrane-bound proteases of the gerbil subfornical organ and choroid plexus: an enzyme histochemical study.

    Science.gov (United States)

    Mitro, A; De Bault, L E

    1994-03-01

    Using enzyme-histochemical methods, the membrane-bound peptidases, gamma-glutamyl transpeptidase (gamma-GTP), microsomal alanyl aminopeptidase (mAAP), glutamyl aminopeptidase (EAP), and dipeptidyl peptidase IV (DPP IV), were studied in microvessels of the gerbil subfornical organ (SFO), choroid plexus adjacent to the SFO, and the ependyma of brain ventricle walls in the vicinity of the SFO. Vessels and microvessels of gerbil SFO and choroid plexus were positive for gamma-GTP, mAAP, and EAP, but negative for DPP IV. Blood-brain barrier (BBB) microvessels in the surrounding brain tissue also showed positive reactions for gamma-GTP, mAAP, and EAP but a negative reaction for DPP IV. Both epithelial cells of the choroid plexus and ependymal cells of the ventricle walls were negative for all four studied enzymes. It is suggested that blood-borne peptide hormones which can be substrates for these membrane-bound proteases can be modulated by gamma-GTP, mAAP, and EAP, but not by DPP IV, when they come in contact with the plasma membrane of the endothelial cells of the vessels in gerbil SFO, choroid plexus, and surrounding brain tissue.

  3. Association of Academic Physiatrists

    Science.gov (United States)

    ... that enhance and improve research and education in academic physiatry. Search AAP Search » Gerard E. Francisco, MD , received the Sidney Licht Lectureship Award at the 10th International Society of Physical and Rehabilitation Medicine World Congress. Michael Boninger, MD , new Vice President ...

  4. NCBI nr-aa BLAST: CBRC-MDOM-04-0142 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MDOM-04-0142 ref|YP_073290.1| NADH dehydrogenase subunit 5 [Pachypsylla venust...a] gb|AAP14655.1| NADH dehydrogenase subunit 5 [Pachypsylla venusta] YP_073290.1 0.039 25% ...

  5. 77 FR 62512 - Radio Broadcasting Services; AM or FM Proposals To Change the Community of License.

    Science.gov (United States)

    2012-10-15

    ... COMMISSION Radio Broadcasting Services; AM or FM Proposals To Change the Community of License. AGENCY... BROADCASTING ASSOCIATION, Station KLXM, Facility ID 184961, BMPED-20120823AAP, From WEATHERFORD, OK, To ARAPAHO, OK; COMMUNITY RADIO PROJECT, Station KZET, Facility ID 173810, BPED-20120914AEF, From CORTEZ, CO,...

  6. Eesti paviljon "Koda" = Estonian pavilion "Koda"

    Index Scriptorium Estoniae

    2015-01-01

    Eesti paviljon "Koda" Hollandi maailmanäitusel "Floriade". Arhitektuurivõistlus 2011. Arhitektid Joel Kopli, Koit Ojaliiv (Kuu Arhitektid), konstruktorid Alar Hammer, Marek Suursalu (Projekt 363). Lauad Kristel Jakobson (Haka Disain), toolid Aap Piho (Maast Furniture), valgustid Margus Triibmann (Keha3)

  7. Gay and Lesbian Parents

    Science.gov (United States)

    ... may benefit from meeting other children who have gay or lesbian parents. You might find a local group of families, or your children might be interested in joining an e-mail list or finding a pen pal. Civil marriage. The AAP supports civil marriage for all parents. ...

  8. Enhancing School Asthma Action Plans: Qualitative Results from Southeast Minnesota Beacon Stakeholder Groups

    Science.gov (United States)

    Egginton, Jason S.; Textor, Lauren; Knoebel, Erin; McWilliams, Deborah; Aleman, Marty; Yawn, Barbara

    2013-01-01

    Background: This study explores ways southeast Minnesota schools currently address asthma problems, identifies areas for improvement, and assesses the potential value of asthma action plans (AAPs) in schools. Methods: Focus groups were used to query stakeholder groups on asthma care in schools. Groups were held separately for elementary school…

  9. Prevalence of Virulence-Related Determinants in Clinical Isolates of Staphylococcus epidermidis

    Science.gov (United States)

    Najar Peerayeh, Shahin; Jazayeri Moghadas, Ali; Behmanesh, Mehrdad

    2016-01-01

    Background Staphylococcus epidermidis, a member of the human flora, is recognized as an opportunistic pathogen and cause of nosocomial infections. Staphylococcus epidermidis surface components are able to establish bacteria on the host surface, and cause infection. Objectives The frequency of icaA, IS256, aap, fbe and bhp in clinical isolates of S. epidermidis were investigated in this study. Materials and Methods Fifty-nine S. epidermidis isolates were collected from blood (50), wound (1), urine (4) and tracheal (4) samples (Tehran, Iran). Staphylococcus epidermidis isolates were identified with conventional bacteriological tests. Virulence-associated genes were detected by specific polymerase chain reactions (PCRs). Results Of the 59 S. epidermidis, fbe was found in 89.8%, while aap and bhp were observed in 64.4% and 15.3% of the samples, respectively. Coexistence of aap and fbe was found in 32 isolates, while coexistence of bhp and fbe was observed in five isolates. Two isolates were negative for the investigated genes. Conclusions Prevalence of fbe and aap was significantly different from similar studies, yet frequency of bhp was in accordance with other studies. Prevalence of icaA and IS256 was not significantly different from some studies while a significant difference was observed when results were compared with some other studies. PMID:27800129

  10. NCBI nr-aa BLAST: CBRC-TGUT-05-0042 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TGUT-05-0042 gb|AAP36559.1| Homo sapiens potassium voltage-gated channel, delay...ed-rectifier, subfamily S, member 3 [synthetic construct] gb|AAX28989.1| potassium voltage-gated channel delay

  11. NCBI nr-aa BLAST: CBRC-OGAR-01-0901 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OGAR-01-0901 gb|AAP36559.1| Homo sapiens potassium voltage-gated channel, delay...ed-rectifier, subfamily S, member 3 [synthetic construct] gb|AAX28989.1| potassium voltage-gated channel delay

  12. NCBI nr-aa BLAST: CBRC-ETEL-01-0884 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0884 gb|AAP36559.1| Homo sapiens potassium voltage-gated channel, delay...ed-rectifier, subfamily S, member 3 [synthetic construct] gb|AAX28989.1| potassium voltage-gated channel delay

  13. NCBI nr-aa BLAST: CBRC-MLUC-01-0761 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MLUC-01-0761 gb|AAP36559.1| Homo sapiens potassium voltage-gated channel, delay...ed-rectifier, subfamily S, member 3 [synthetic construct] gb|AAX28989.1| potassium voltage-gated channel delay

  14. NCBI nr-aa BLAST: CBRC-EEUR-01-1046 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-1046 gb|AAP36559.1| Homo sapiens potassium voltage-gated channel, delay...ed-rectifier, subfamily S, member 3 [synthetic construct] gb|AAX28989.1| potassium voltage-gated channel delay

  15. Studying the role of vision in cycling : critique on restricting research to fixation behaviour.

    NARCIS (Netherlands)

    Schepers, J.P. Brinker, B.P.L.M. den Waard, D. de Twisk, D.A.M. Schwab, D.A.M. & Smeets, J.B.J.

    2013-01-01

    In a recent study published in Accident Analysis & Prevention, Vansteenkiste et al. (2013, http://dx.doi.org/10.1016/j.aap.2012.11.025) – as one of the first in this field – investigated the visual control of bicycle steering. They undertook the interesting task of testing cyclists’ eye fixation beh

  16. For Kids Playing Pokemon Go, Catch These Safety Tips

    Science.gov (United States)

    ... an "augmented reality" game. That means it's a game that is partly virtual and partly based in reality. Players need to go out into the real world. "You can't just play this game from your living room," AAP spokeswoman Dr. Elizabeth ...

  17. NCBI nr-aa BLAST: CBRC-TSYR-01-1170 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TSYR-01-1170 ref|NP_898745.1| putative cadmium resistance protein (CadA) [Rhod...ococcus erythropolis] gb|AAP74015.1| putative cadmium resistance protein (CadA) [Rhodococcus erythropolis] NP_898745.1 0.14 29% ...

  18. Surveying Turkish High School and University Students' Attitudes and Approaches to Physics Problem Solving

    Science.gov (United States)

    Balta, Nuri; Mason, Andrew J.; Singh, Chandralekha

    2016-01-01

    Students' attitudes and approaches to physics problem solving can impact how well they learn physics and how successful they are in solving physics problems. Prior research in the U.S. using a validated Attitude and Approaches to Problem Solving (AAPS) survey suggests that there are major differences between students in introductory physics and…

  19. NCBI nr-aa BLAST: CBRC-ATHA-02-0010 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ATHA-02-0010 ref|NP_179704.2| unknown protein [Arabidopsis thaliana] gb|AAM981...39.1| unknown protein [Arabidopsis thaliana] gb|AAP37861.1| At2g21080 [Arabidopsis thaliana] NP_179704.2 0.0 100% ...

  20. Animal-assisted dyadic therapy: A therapy model promoting development of the reflective function in the parent-child bond.

    Science.gov (United States)

    Shani, Liat

    2017-01-01

    Animal-assisted psychotherapy (AAP) inherently incorporates standpoints, interventions, and ways of action promoting the development of the reflective function and mentalization, and thus has special value for parent-child psychotherapy. Two central tools in AAP contribute to this process. The first is the ethical stance of the therapist, who sees the animals as full partners in the therapy situation, respecting them as subjects with needs, desires, and thoughts of their own. The second tool combines nonverbal communication with animals together with the relating, in the here and now, to the understanding and decoding of body language of everyone in the setting. Nonverbal communication in AAP enables access to implicit communication patterns occurring between parent and child. This article provides a survey of theoretical development and research constituting a basis for the development of therapeutic approaches for the improvement of parent-children dynamics, followed by a description of a dyadic therapy model of a mentalization-based treatment originating from a psychoanalytic-relational orientation. Clinical examples are provided to illustrate AAP processes in parent-child psychotherapy (consent was received for examples that were not aggregated).

  1. Dickkopf-related protein 3 is a potential Abeta-associated protein in Alzheimer's Disease

    NARCIS (Netherlands)

    Bruggink, K.A.; Kuiperij, H.B.; Gloerich, J.; Otte-Holler, I.; Rozemuller, A.J.; Claassen, J.A.H.R.; Kusters, B.; Verbeek, M.M.

    2015-01-01

    Amyloid-beta (Abeta) is the most prominent protein in Alzheimer's disease (AD) senile plaques. In addition, Abeta interacts with a variety of Abeta-associated proteins (AAPs), some of which can form complexes with Abeta and influence its clearance, aggregation or toxicity. Identification of novel AA

  2. Recent evidence and potential mechanisms underlying weight gain and insulin resistance due to atypical antipsychotics

    Directory of Open Access Journals (Sweden)

    Ana Maria Volpato

    2013-09-01

    Full Text Available Objective: Atypical antipsychotics (AAPs promote obesity and insulin resistance. In this regard, the main objective of this study was to present potential mechanisms and evidence concerning side effects of atypical antipsychotics in humans and rodents. Method: A systematic review of the literature was performed using the MEDLINE database. We checked the references of selected articles, review articles, and books on the subject. Results: This review provides consistent results concerning the side effects of olanzapine (OL and clozapine (CLZ, whereas we found conflicting results related to other AAPs. Most studies involving humans describe the effects on body weight, adiposity, lipid profile, and blood glucose levels. However, it seems difficult to identify an animal model replicating the wide range of changes observed in humans. Animal lineage, route of administration, dose, and duration of treatment should be carefully chosen for the replication of the findings in humans. Conclusions: Patients undergoing treatment with AAPs are at higher risk of developing adverse metabolic changes. This increased risk must be taken into account when making decisions about treatment. The influence of AAPs on multiple systems is certainly the cause of such effects. Specifically, muscarinic and histaminergic pathways seem to play important roles.

  3. NCBI nr-aa BLAST: CBRC-XTRO-01-0066 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-0066 ref|NP_942999.1| putative entry exclusion protein [Ralstonia eutr...opha H16] gb|AAP86113.1| putative entry exclusion protein [Ralstonia eutropha] NP_942999.1 3e-05 27% ...

  4. NCBI nr-aa BLAST: CBRC-DNOV-01-1344 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-1344 ref|YP_223898.1| putative tape measure protein [Lactobacillus pha...ge phiJL-1] gb|AAP74525.1| putative tape measure protein [Lactobacillus plantarum bacteriophage phiJL-1] YP_223898.1 0.015 22% ...

  5. Drosophila melanogaster females restore their attractiveness after mating by removing male anti-aphrodisiac pheromones

    NARCIS (Netherlands)

    Laturney, Meghan; Billeter, Jean-Christophe

    2016-01-01

    Males from many species ensure paternity by preventing their mates from copulating with other males. One mate-guarding strategy involves marking females with anti-aphrodisiac pheromones (AAPs), which reduces the females' attractiveness and dissuades other males from courting. Since females benefit f

  6. Drosophila melanogaster females restore their attractiveness after mating by removing male anti-aphrodisiac pheromones.

    Science.gov (United States)

    Laturney, Meghan; Billeter, Jean-Christophe

    2016-08-03

    Males from many species ensure paternity by preventing their mates from copulating with other males. One mate-guarding strategy involves marking females with anti-aphrodisiac pheromones (AAPs), which reduces the females' attractiveness and dissuades other males from courting. Since females benefit from polyandry, sexual conflict theory predicts that females should develop mechanisms to counteract AAPs to achieve additional copulations, but no such mechanisms have been documented. Here we show that during copulation Drosophila melanogaster males transfer two AAPs: cis-Vaccenyl Acetate (cVA) to the females' reproductive tract, and 7-Tricosene (7-T) to the females' cuticle. A few hours after copulation, females actively eject cVA from their reproductive tract, which results in increased attractiveness and re-mating. Although 7-T remains on those females, we show that it is the combination of the two chemicals that reduces attractiveness. To our knowledge, female AAP ejection provides the first example of a female mechanism that counter-acts chemical mate-guarding.

  7. Phosphorus forms and bioavailability of lake sediments in the middle and lower reaches of Yangtze River

    Institute of Scientific and Technical Information of China (English)

    ZHU; Guangwei; QIN; Boqiang; ZHANG; Lu

    2006-01-01

    Forms of phosphorus in sediments from 25 lakes in the middle and lower reaches of Yangtze River were analyzed by the sequential extraction procedure. Contents and spatial distrubution of algal available phosphorus (AAP) in sediments of Lake Taihu, the third largest freshwater lake of China, were also studied. Relationships between phosphorus forms in sediment and macrophytes coverage in sample sites, as well as phosphorus forms in sediments and chlorophyal contents in lake water were discussed. Exchangeable form of phosphorus (Ex-P) in surface sediments was significantly positive correlative to total phosphorus (TP), dissolved total phosphorus (DTP) and soluble reactive phosphorus (SRP) contents in the lake water. Bioavailable phosphorus (Bio-P) contents in sediments from macrophytes dominant sites were significantly lower than that in no macrophyte sites. In Lake Taihu, Ex-P content in top 3 cm sediment was highest.However, content of ferric fraction phosphorus (Fe-P) was highest in 4-10 cm. Bioavalilble phosphorus (Bio-P) contents in surface sediments positively correlated to Chlorophyll a contents in water of Lake Taihu with significant difference. Therefore, contents of Bio-P and AAP could be acted as the indicators of risks of internal release of phosphorus in the shallow lakes. It was estimated that there were 268.6 ton AAP in top 1 cm sediments in Lake Taihu. Sediment suspension caused by strong wind-induced wave disturbance could carry plenty of AAP into water in large shallow lakes like Lake Taihu.

  8. Simultaneous Detection of Phenols and Anilines in Oilfield Waste Water

    Institute of Scientific and Technical Information of China (English)

    Yuan Cunguang; Feng Chengwu

    1996-01-01

    @@ Phenols and aromatic anilines are monitored in many countries , because both of them pollute environment seriously. The methods of 4-AAP(4-Aminoantipyrine)photometric detection of volatile phenols and naphthalene -ethyl-diamine-azo photometric detection of anilines are recommended by the National Environmental Protection Bureau, China (NEPBC).

  9. NCBI nr-aa BLAST: CBRC-DYAK-04-0025 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DYAK-04-0025 ref|NP_834435.1| Spore germination protein IA [Bacillus cereus AT...CC 14579] gb|AAP11636.1| Spore germination protein IA [Bacillus cereus ATCC 14579] NP_834435.1 0.044 23% ...

  10. AcEST: BP921278 [AcEST

    Lifescience Database Archive (English)

    Full Text Available uitin-protein ligase Arkadia OS=Pon... 31 1.7 sp|Q925Q8|DACH2_MOUSE Dachshund homolog 2 OS=Mus musculus GN=D...HAFHSQISSHATSHPVAPPPPTHLAST 716 Query: 221 EAP 229 AP Sbjct: 717 AAP 719 >sp|Q925Q8|DACH2_MOUSE Dachshund

  11. Grr1p is required for transcriptional induction of amino acid permease genes and proper transcriptional regulation of genes in carbon metabolism of Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Eckert-Boulet, Nadine; Regenberg, Birgitte; Nielsen, Jens

    2005-01-01

    and a grr1 Delta strain and adding citrulline in the exponential phase. Whole-genome transcription analyses were performed on samples from each cultivation, both immediately before and 30 min after citrulline addition. Transcriptional induction of the AAP genes AGP1, BAP2, BAP3, DIP5, GNP1 and TAT1 is fully...

  12. NCBI nr-aa BLAST: CBRC-DNOV-01-2484 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-2484 ref|YP_006355.1| ATP synthase F0 subunit 6 [Siphonodentalium loba...tum] gb|AAP91676.1| ATP synthase F0 subunit 6 [Siphonodentalium lobatum] YP_006355.1 5e-04 29% ...

  13. NCBI nr-aa BLAST: CBRC-XTRO-01-3773 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-3773 ref|YP_003772.1| myristylated membrane protein [Ambystoma tigrinu...m virus] gb|AAP33178.1| myristylated membrane protein [Ambystoma tigrinum stebbensi virus] YP_003772.1 0.13 56% ...

  14. NCBI nr-aa BLAST: CBRC-XTRO-01-3553 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-3553 ref|YP_003772.1| myristylated membrane protein [Ambystoma tigrinu...m virus] gb|AAP33178.1| myristylated membrane protein [Ambystoma tigrinum stebbensi virus] YP_003772.1 2.4 53% ...

  15. NCBI nr-aa BLAST: CBRC-XTRO-01-2527 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-2527 ref|YP_003772.1| myristylated membrane protein [Ambystoma tigrinu...m virus] gb|AAP33178.1| myristylated membrane protein [Ambystoma tigrinum stebbensi virus] YP_003772.1 0.035 56% ...

  16. NCBI nr-aa BLAST: CBRC-XTRO-01-0562 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-0562 ref|YP_003772.1| myristylated membrane protein [Ambystoma tigrinu...m virus] gb|AAP33178.1| myristylated membrane protein [Ambystoma tigrinum stebbensi virus] YP_003772.1 0.045 56% ...

  17. NCBI nr-aa BLAST: CBRC-XTRO-01-0480 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-0480 ref|YP_003772.1| myristylated membrane protein [Ambystoma tigrinu...m virus] gb|AAP33178.1| myristylated membrane protein [Ambystoma tigrinum stebbensi virus] YP_003772.1 0.045 56% ...

  18. NCBI nr-aa BLAST: CBRC-XTRO-01-0714 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-0714 ref|YP_003772.1| myristylated membrane protein [Ambystoma tigrinu...m virus] gb|AAP33178.1| myristylated membrane protein [Ambystoma tigrinum stebbensi virus] YP_003772.1 0.035 56% ...

  19. Vitamin D in Health and Disease in Adolescents: When to Screen, Whom to Treat, and How to Treat.

    Science.gov (United States)

    Golden, Neville H; Carey, Dennis E

    2016-01-01

    The existing guidelines on screening and treatment are confusing because different guidelines target different populations. The IOM and AAP guidelines target generally healthy populations, whereas the Endocrine Society and other subspecialty guidelines target individuals with specific medical conditions associated with increased bone fragility. These distinctions have not always been well articulated. For healthy adolescents, the AAP does not recommend universal screening or screening of obese or dark-skinned individuals. Increased dietary intake of vitamin D is recommended, and vitamin D supplementation can be considered if the RDA cannot be met. For adolescents with chronic medical illnesses associated with increased fracture risk, screening for vitamin D deficiency should be performed by obtaining a serum 25-OHD level. Those found to be deficient (25-OHD level vitamin D2 or vitamin D3 higher than the daily requirement (as discussed in the section on vitamin D and chronic disease), followed by a maintenance dose. A repeat 25-OHD level should be obtained after the therapeutic course is completed. Some experts advocate for achievement of 25-OHD levels greater than 30 ng/mL in conditions associated with increased bone fragility, and several pediatric subspecialty organizations have made recommendations specific to the diseases they treat. In such instances, the recommendations of the pediatric subspecialty organizations should take precedence over the AAP recommendations for adolescents with chronic illnesses associated with increased bone fragility because the AAP recommendations were primarily targeted at a healthy population.

  20. NCBI nr-aa BLAST: CBRC-OSAT-07-0033 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OSAT-07-0033 ref|YP_025744.1| NADH dehydrogenase subunit 4 [Ornithoctonus huwe...na] gb|AAP51154.2| NADH dehydrogenase subunit 4 [Ornithoctonus huwena] YP_025744.1 3.2 25% ...

  1. NCBI nr-aa BLAST: CBRC-TTRU-01-0100 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-0100 ref|YP_025744.1| NADH dehydrogenase subunit 4 [Ornithoctonus huwe...na] gb|AAP51154.2| NADH dehydrogenase subunit 4 [Ornithoctonus huwena] YP_025744.1 0.012 25% ...

  2. Large accumulations of maize streak virus in the filter chamber and midgut cells of the leafhopper vector Cicadulina mbila.

    Science.gov (United States)

    Ammar, El-Desouky; Gargani, Daniel; Lett, Jean M; Peterschmitt, Michel

    2009-01-01

    Maize streak virus (MSV, Mastrevirus, Geminiviridae) is persistently transmitted by Cicadulina mbila, apparently without propagation in its leafhopper vector. MSV was shown earlier by quantitative PCR to accumulate in the alimentary canal of C. mbila. We examined the alimentary canals of C. mbila leafhoppers that acquired MSV from diseased plants for various acquisition access periods (AAP) by immunofluorescence confocal laser scanning microscopy (iCLSM) and by immunogold labelling transmission electron microscopy (iTEM). Following a 7-day AAP and a 7-day inoculation period (IP) on healthy seedlings, MSV was detected by iCLSM mainly in the filter chamber and anterior midgut. Using iTEM, large accumulations of MSV particles, usually enclosed in membranous vesicles, were detected only in cells of the midgut, inside and outside the filter chamber, following 14- or 30-day AAPs, and also following 7-day AAP and 7-day IP on healthy plants. No virus was detected in the control non-vector species C. chinaï. Coated pits or vesicles, typical of clathrin-mediated endocytosis, were not observed. We discuss an alternative endocytosis pathway and suggest that the MSV accumulations are stored in endosomes in the midgut epithelial cells.

  3. NCBI nr-aa BLAST: CBRC-CINT-01-0121 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CINT-01-0121 ref|NP_999827.1| polycystic kidney disease protein 2 [Strongyloce...ntrotus purpuratus] gb|AAP35006.1| polycystic kidney disease protein 2 [Strongylocentrotus purpuratus] NP_999827.1 0.26 22% ...

  4. Screen Time May Not Be So Bad for Teens After All

    Science.gov (United States)

    ... screen time appear unlikely to have significant negative effect." However, several child health experts said they weren't ready to ... AAP encourages parents to sit down with their children and calculate how many ... key health behaviors -- like sleep and school and social activities -- and ...

  5. Osteoclastogenesis is influenced by modulation of gap junctional communication with antiarrhythmic peptides.

    Science.gov (United States)

    Kylmäoja, Elina; Kokkonen, Hanna; Kauppinen, Kyösti; Hussar, Piret; Sato, Tetsuji; Haugan, Ketil; Larsen, Bjarne Due; Tuukkanen, Juha

    2013-03-01

    Osteoclasts are formed by the fusion of mononuclear precursor cells of the monocyte-macrophage lineage. Among several putative mechanisms, gap-junctional intercellular communication (GJC) has been proposed to have a role in osteoclast fusion and bone resorption. We examined the role of GJC in osteoclastogenesis and in vitro bone resorption with mouse bone marrow hematopoietic stem cells and RAW 264.7 cells. Blocking of gap junctions with 18-α-glycyrrhetinic acid (18GA) led to inhibition of osteoclastogenesis and in vitro bone resorption. Similarly, the GJC inhibitor GAP27 inhibited osteoclast formation. GJC modulation with the antiarrhythmic peptides (AAPs) led to increased amounts of multinuclear RAW 264.7 osteoclasts as well as increased number of nuclei per multinuclear cell. In the culture of bone marrow hematopoietic stem cells in the presence of bone marrow stromal cells AAP reduced the number of osteoclasts, and coculture of MC3T3-E1 preosteoblasts with RAW 264.7 macrophages prevented the action of AAPs to promote osteoclastogenesis. The present data indicate that AAPs modulate the fusion of the pure culture of cells of the monocyte-macrophage lineage. However, the fusion is influenced by GJC in cells of the osteoblast lineage.

  6. A Novel Approach to Critical Congenital Heart Disease (CCHD Screening at Moderate Altitude

    Directory of Open Access Journals (Sweden)

    Erin Lueth

    2016-07-01

    Full Text Available The American Academy of Pediatrics (AAP has endorsed Critical Congenital Heart Disease (CCHD screening using pulse oximetry nationwide, but, however, acknowledges that altitude may impact failure rates and alternative algorithms may be required at high altitudes. We therefore evaluated a modified screening protocol at an altitude of 6200 feet with the hypothesis that modifications could decrease failure rates. We evaluated 2001 well, newborn infants ≥35 weeks gestation using a modified protocol, which included a lower saturation cutoff for the first screen (85% instead of the AAP recommended 90% and an oxygen hood intervention between the first two screens. Using our modified screening algorithm, we found a 0.3% failure rate, which was similar to the 0.2% sea-level rate and statistically different from the 1.1% rate identified in a recent study at similar altitude. Had the AAP protocol been used, the failure rate would have increased to 0.8%, which is similar to prior reports near this altitude. Echocardiograms were performed on failing newborns with no CCHD identified. A Birth Defects Registry Database review demonstrated one newborn with CCHD was missed after meeting AAP passing criteria. Overall, this study demonstrates that an alternative algorithm can be implemented at moderate altitude with decreased failure rate and comparable false negative rate.

  7. 扑热息痛肝损伤机制研究进展%Advances on mechanisms of acetaminophen-induced hepatic injury

    Institute of Scientific and Technical Information of China (English)

    顾兴丽; 孙继红; 季晖

    2009-01-01

    Acetaminophen(AAP) -induced hepatic injury is one of the common causes of drug-induced hepatic injury. Up to date, the mechanisms of AAP-induced hepatic injury are still incompletely understood. Recent advances suggest that reactive metabolite formation, glutathione depletion, alkylation of proteins, especially mitochondrial proteins and peroxynitrite formation are critical initiating events for the toxicity. This review will focus on more recent advances in mitochon- drial dysfunction after AAP overdose. Additional, oxi-dative stress and inflammatory mediators are also important for the overall outcome.%扑热息痛(AAP)肝损伤是药物性肝损伤的常见原因之一.但迄今为止,其肝损伤机制仍不完全清楚.最新研究进展指出活性代谢产物的形成、谷胱甘肽的耗竭、线粒体蛋白的烷化和过氧化亚硝酸盐的形成是主要原因.本文主要描述了AAP过量所致的线粒体功能异常的研究进展,另外也综述了氧化应激和炎症介质在扑热息痛肝损伤机制中的作用.

  8. Atlantic City and the Boardwalk: 1932--1976.

    Science.gov (United States)

    Seldin, Donald W

    2008-04-01

    Memories of the meetings in Atlantic City of the two major academic medical societies, the AAP and the ASCI, are enveloped by a vague and unsettling nostalgia. Dominating the scene was the Boardwalk--a site of unexpected encounters, often with long-forgotten colleagues, evoking a feeling of shared intellectual excitement and rich personal ties.

  9. Overweight and Obesity (For Parents)

    Science.gov (United States)

    ... The AAP recommends that no TVs, computers, or video games be in children's bedrooms and that screens be turned off during mealtimes. Exercise and Physical Activity Many kids don't get enough physical activity. Although physical education (PE) in schools can help kids get up ...

  10. Building Resilience in Children

    Science.gov (United States)

    ... D., MS Ed, FAAP, a pediatrician specializing in adolescent medicine at The Children’s Hospital of Philadelphia (CHOP), has joined forces with the American Academy of Pediatrics (AAP) to author A Parent’s Guide to Building Resilience in Children and Teens: Giving Your Child Roots ...

  11. Effect of matrix on the metal poisoning of REY catalysts

    Energy Technology Data Exchange (ETDEWEB)

    Yang, S.J.; Chen, Y.W. [National Central Univ., Chungli (Taiwan, Province of China). Dept. of Chemical Engineering; Li, C. [Chinese Petroleum Corp., Chiayi (Taiwan, Province of China). Refining and Manufacturing Research Inst.

    1995-04-01

    The effect of matrix on the resistance of vanadium and nickel poisoning of the REY zeolite has been investigated by X-ray diffraction, nitrogen adsorption, and n-hexane cracking reaction. Alumina (Al{sub 2}O{sub 3}), magnesia-alumina (MgO-Al{sub 2}O{sub 3}), alumina-aluminum phosphate (AAP), and magnesia-alumina-aluminum phosphate (MgAAP) were used as matrices of REY. The presence of matrix can increase the resistance of REY to steam deactivation. AAP has a better hydrothermal stability than the other matrics. MgO-Al{sub 2}O{sub 3} matrix demonstrates the highest ability to capture vanadium due to the basicity of magnesia. There is an interaction between vanadium and nickel. This interaction inhibits the destruction of REY structure caused by vanadium. AAP has a strong interaction with nickel. The stronger the nickel-matrix interaction, the less poison effect of nickel. In addition, the strong interaction leads to the decrease in nickel`s ability to retard the destruction of REY structure by vanadium.

  12. Gene : CBRC-CJAC-01-0975 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CJAC-01-0975 UN A Melanocortins receptors MSHR_CALJA 0.0 100% sp|Q864H7|MSHR_C...R) gb|AAP30994.1| melanocortin-1 receptor [Callithrix jacchus] 0.0 100% MPMQGAQRKLLGSLNSTPTATSNPGLAANHTGAPCL

  13. Gene : CBRC-CJAC-01-1020 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CJAC-01-1020 UN A Orphan receptors GPR34_PANTR 0.0 93% gb|AAP04277.1| G-protei...n-coupled receptor GPR34 [Callithrix jacchus] 0.0 100% MRSHTITMMTTTSVSSWPYSSHRMCFETNHSDQSPQNFSGRPDVTTCPMDENL

  14. NCBI nr-aa BLAST: CBRC-CJAC-01-0975 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CJAC-01-0975 sp|Q864H7|MSHR_CALJA Melanocyte-stimulating hormone receptor (MSH...-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R) gb|AAP30994.1| melanocortin-1 receptor [Callithrix jacchus] Q864H7 0.0 100% ...

  15. NCBI nr-aa BLAST: CBRC-MDOM-05-0629 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MDOM-05-0629 ref|YP_025950.1| NADH dehydrogenase subunit 2 [Strigops habroptil...us] gb|AAP47794.1| NADH dehydrogenase subunit 2 [Strigops habroptilus] YP_025950.1 0.28 24% ...

  16. NCBI nr-aa BLAST: CBRC-LAFR-01-0231 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0231 ref|NP_852970.1| hypothetical protein MGA_0954 [Mycoplasma galliseptic...um R] gb|AAP56538.1| conserved hypothetical protein [Mycoplasma gallisepticum R] NP_852970.1 0.033 23% ...

  17. NCBI nr-aa BLAST: CBRC-DDIS-02-0111 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DDIS-02-0111 ref|NP_853044.1| hypothetical protein MGA_1103 [Mycoplasma galliseptic...um R] gb|AAP56612.1| conserved hypothetical protein [Mycoplasma gallisepticum R] NP_853044.1 0.003 24% ...

  18. NCBI nr-aa BLAST: CBRC-DNOV-01-0511 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-0511 ref|NP_852884.1| hypothetical protein MGA_0805 [Mycoplasma galliseptic...um R] gb|AAP56452.1| conserved hypothetical protein [Mycoplasma gallisepticum R] NP_852884.1 0.73 23% ...

  19. NCBI nr-aa BLAST: CBRC-DDIS-02-0086 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DDIS-02-0086 ref|NP_853044.1| hypothetical protein MGA_1103 [Mycoplasma galliseptic...um R] gb|AAP56612.1| conserved hypothetical protein [Mycoplasma gallisepticum R] NP_853044.1 0.003 24% ...

  20. NCBI nr-aa BLAST: CBRC-ATHA-05-0017 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ATHA-05-0017 ref|NP_852878.1| hypothetical protein MGA_0797 [Mycoplasma galliseptic...um R] gb|AAP56446.1| unique hypothetical protein [Mycoplasma gallisepticum R] NP_852878.1 0.43 26% ...

  1. NCBI nr-aa BLAST: CBRC-BTAU-01-1813 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-1813 ref|NP_852880.1| hypothetical protein MGA_0800 [Mycoplasma galliseptic...um R] gb|AAP56448.1| unique hypothetical protein [Mycoplasma gallisepticum R] NP_852880.1 0.39 21% ...

  2. NCBI nr-aa BLAST: CBRC-DNOV-01-0787 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-0787 ref|NP_853432.1| hypothetical protein MGA_0477 [Mycoplasma galliseptic...um R] gb|AAP57000.1| unique hypothetical protein [Mycoplasma gallisepticum R] NP_853432.1 0.047 27% ...

  3. Using Acetaminophen's Toxicity Mechanism to Enhance Cisplatin Efficacy in Hepatocarcinoma and Hepatoblastoma Cell Lines

    Directory of Open Access Journals (Sweden)

    Alexander J. Neuwelt

    2009-10-01

    Conclusions: Our results suggest that a chemotherapeutic regimen containing both AAP and CDDP with delayed NAC rescue has the potential to enhance chemotherapeutic efficacy while decreasing adverse effects. This would be a promising approach particularly for hepatoblastomas regardless of cellular CYP2E1 protein level but could also be beneficial in other malignancies.

  4. 75 FR 47819 - Workshop on Optimizing Clinical Trial Design for the Development of Pediatric Cardiovascular Devices

    Science.gov (United States)

    2010-08-09

    ... support from the American Academy of Pediatrics (AAP), the American College of Cardiology (ACC), and the... developing devices for the pediatric cardiology market. The information gathered in this and future workshops will help to develop future guidance on optimal designs for pediatric cardiology device trials....

  5. Pediatricians Offer Heads-Up for Preventing Soccer Injuries

    Science.gov (United States)

    ... 2017 SATURDAY, Jan. 14, 2017 (HealthDay News) -- As children's soccer has become more popular in the United States, ... running, twisting, shooting and landing, the AAP explained. Children who are injured while playing soccer most often sustain sprains and strains. Bruises are ...

  6. [Acute accidental poisoning in children: aspects of their epidemiology, aetiology, and outcome at the Charles de Gaulle Paediatric Hospital in Ouagadougou (Burkina Faso)].

    Science.gov (United States)

    Kouéta, Fla; Dao, Lassina; Yé, Diarra; Fayama, Zéinabou; Sawadogo, Alphonse

    2009-01-01

    Accidents are a daily concern in the paediatric ward because of their frequency, diversity and severity. Acute accidental poisoning (AAP) accounts for an important portion of these. To help improvement management of AAP, we conducted a retrospective study covering a period of 2 years from January 2005 to December 2006 at Charles de Gaulle Paediatric University Hospital in Ouagadougou. Of 9390 admissions during the study period, 123 children, or 1.3%, were admitted for poisoning. A cumulative average of 11 were admitted monthly, with a peak of 16 patients in April 2005 and 2006, together. AAP was most common among children aged 1 to 4 years. Their mean age was 3 years and ranged from 6 days to 12 years. Boys outnumbered girls, with a sex ratio of 1.2. Mothers of more than half (61%) of the children poisoned worked in the home. Household products accounted for 44.7% of AAPs, followed by drug (22.7%) and food (22%) poisoning. Kerosene and other petroleum products topped the list of household products, with 54.5%. Tranquilizers (46.4%) and dairy products (37%) dominated the drug and food poisoning categories. Immediate outcome was fatal in 3% of cases, and three quarters of these deaths occurred during drug poisoning of children aged 1 to 4 years. The mean hospital stay was 2 days, and ranged from 0 to 9 days. Health officials, the media, and community outreach must all help to increase awareness about the dangers of poisoning and of preventive measures.

  7. Korsten : tellimata tellised = Chimney : an outside job / Andres Aule

    Index Scriptorium Estoniae

    Aule, Andres

    2012-01-01

    Aap Kaur Suvi kavandatud Tallinna linnainstallatsioonide festivali "LIFT11" installatsioonist "Korsten", mis pidi seisnema Tauno Kangro skulptuuri "Lõbus korstnapühkija" ümber ajutise telliskorstna ehitamises. Lift11 jättis selle installatsiooni ära, kuid ootamatult sai "Korsten" kodanikualgatusena 8. IX 2011 teoks

  8. Rundum artist-run space and its elusive form / Hanna Laura Kaljo, Mari-Leen Kiipli, Kulla Laas ... [jt.

    Index Scriptorium Estoniae

    2015-01-01

    Rundum on 2013. a septembris Tallinnas loodud liikuv loominguline platvorm, mille eesmärgiks on suhestuda erinevate kohtadega, reageerida tühikutele Eesti loomemaastikus ning uurida sealjuures ka omaalgatuslike praktikate võimalikkust kohalikus kontekstis. Vestlusringis Rundumi algatajad Mari-Leen Kiipli, Kulla Laas, Aap Tepper, Mari Volens, Kristina Õllek

  9. TEMPLATE POLYMERIZATION OF N-VINYLIMIDAZOLE ALONG POLY(METHACRYLIC ACID) IN WATER .2. KINETICS OF THE TEMPLATE POLYMERIZATION

    NARCIS (Netherlands)

    VANDEGRAMPEL, HT; TAN, YY; CHALLA, G

    1991-01-01

    The template polymerization of N-vinylimidazole (VIm) along poly(methacrylic acid) (PMAA) in water at 50-degrees-C with 2,2'-azobis(2-amidinopropane).2HCl (AAP) as initiator was studied by using variable initiator and monomer concentrations at constant [PMAA]/[VIm]0. From the order in [VIm] it was c

  10. An Archeological Overview and Management Plan for the Hays Army Ammunition Plant, Allegheny County, Pennsylvania.

    Science.gov (United States)

    1984-05-07

    Society of Professional Archeologists in field, collections, and archival research; administration; museology ; teaching; and historical archeology...evidence of broad regional cultural interactions throughout the prehistoric Paloo-Indian, Archaic, and Woodland tra- ditions. As discussed in 2.1.1...available in draft for consultation by Hays AAP facility personnel (Stephanie Rodeffer, personal co=nuication 1983). In addition, the Carnegie Museum has

  11. Stripping Voltammetric Determination of Analgesics in Their Pharmaceuticals Using Nano-Riboflavin-Modified Glassy Carbon Electrode

    Directory of Open Access Journals (Sweden)

    Gopalakrishnan Gopu

    2011-01-01

    Full Text Available Cyclic voltammetric behaviors of three analgesics, acetaminophen (AAP, acetylsalicylic acid (ASA, and dipyrone (DP, were studied using nano-riboflavin-modified glassy carbon electrode. One well-defined oxidation peak each for AAP and ASA and three oxidation peaks for DP were observed. The influence of pH, scan rate, and concentration reveals irreversible diffusion controlled reaction. The SEM analysis confirmed good accumulation of the drugs on the electrode surface. Calibration was made under the maximum peak current conditions. The concentration range studied for the determination of drugs was 0.02 to 0.4 μg mL−1 for AAP and ASA and 0.025 to 0.4 μg mL−1 for DP. The lower limit of detection observed for AAP, ASA, and DP was 0.016, 0.007 μg mL−1, and 0.013 μg mL−1, respectively. The suitability of the method for the determination of these analgesics in pharmaceutical preparations and urine samples was also ascertained.

  12. Early childhood adversity, toxic stress, and the role of the pediatrician: translating developmental science into lifelong health.

    Science.gov (United States)

    Garner, Andrew S; Shonkoff, Jack P

    2012-01-01

    Advances in a wide range of biological, behavioral, and social sciences are expanding our understanding of how early environmental influences (the ecology) and genetic predispositions (the biologic program) affect learning capacities, adaptive behaviors, lifelong physical and mental health, and adult productivity. A supporting technical report from the American Academy of Pediatrics (AAP) presents an integrated ecobiodevelopmental framework to assist in translating these dramatic advances in developmental science into improved health across the life span. Pediatricians are now armed with new information about the adverse effects of toxic stress on brain development, as well as a deeper understanding of the early life origins of many adult diseases. As trusted authorities in child health and development, pediatric providers must now complement the early identification of developmental concerns with a greater focus on those interventions and community investments that reduce external threats to healthy brain growth. To this end, AAP endorses a developing leadership role for the entire pediatric community-one that mobilizes the scientific expertise of both basic and clinical researchers, the family-centered care of the pediatric medical home, and the public influence of AAP and its state chapters-to catalyze fundamental change in early childhood policy and services. AAP is committed to leveraging science to inform the development of innovative strategies to reduce the precipitants of toxic stress in young children and to mitigate their negative effects on the course of development and health across the life span.

  13. Infection and inflammatory mechanisms

    NARCIS (Netherlands)

    Van Dyke, Thomas E.; van Winkelhoff, Arie Jan

    2013-01-01

    This introductory article examines the potential mechanisms that may play a role in the associations between periodontitis and the systemic conditions being considered in the EFP/AAP Workshop in Segovia, Spain. Three basic mechanisms have been postulated to play a role in these interactions; metasta

  14. Assessing Attachment Representations in Adolescents: Discriminant Validation of the Adult Attachment Projective Picture System.

    Science.gov (United States)

    Gander, Manuela; George, Carol; Pokorny, Dan; Buchheim, Anna

    2017-04-01

    The contribution of attachment to human development and clinical risk is well established for children and adults, yet there is relatively limited knowledge about attachment in adolescence due to the poor availability of construct valid measures. The Adult Attachment Projective Picture System (AAP) is a reliable and valid instrument to assess adult attachment status. This study examines for the first time the discriminant validity of the AAP in adolescents. In our sample of 79 teenagers between 15 and 18 years, 42 % were classified as secure, 34 % as insecure-dismissing, 13 % as insecure-preoccupied and 11 % as unresolved. The results demonstrated discriminant validity for using the AAP in that age group, with no associations between attachment classifications and verbal intelligence, social desirability, story length or sociodemographic variables. These results poise the AAP to be used in clinical intervention and large-scale research investigating normative and atypical developmental correlates and sequelae of attachment, including psychopathology in adolescence.

  15. NCBI nr-aa BLAST: CBRC-ETEL-01-0133 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0133 ref|NP_874194.1| putative enterobacterial common antigen polymerase [Haemophilus... ducreyi 35000HP] gb|AAP96583.1| putative polysaccharide biosynthesis protein [Haemophilus ducreyi 35000HP] NP_874194.1 1.9 29% ...

  16. NCBI nr-aa BLAST: CBRC-LAFR-01-1699 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-1699 ref|NP_874008.1| putative sodium/alanine symporter [Haemophilus d...ucreyi 35000HP] gb|AAP96397.1| putative sodium/alanine symporter [Haemophilus ducreyi 35000HP] NP_874008.1 2.0 23% ...

  17. NCBI nr-aa BLAST: CBRC-XTRO-01-2525 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-2525 ref|NP_873727.1| rod shape-determining protein MreD [Haemophilus ...ducreyi 35000HP] gb|AAP96116.1| rod shape-determining protein MreD [Haemophilus ducreyi 35000HP] NP_873727.1 0.35 24% ...

  18. NCBI nr-aa BLAST: CBRC-ACAR-01-0210 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ACAR-01-0210 ref|NP_873236.1| branched-chain amino acid carrier protein [Haemophilus... ducreyi 35000HP] gb|AAP95625.1| branched-chain amino acid carrier protein [Haemophilus ducreyi 35000HP] NP_873236.1 1.2 22% ...

  19. NCBI nr-aa BLAST: CBRC-PMAR-01-0463 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PMAR-01-0463 ref|NP_833085.1| Collagen-like triple helix repeat protein [Bacil...lus cereus ATCC 14579] gb|AAP10286.1| Collagen-like triple helix repeat protein [Bacillus cereus ATCC 14579] NP_833085.1 5e-32 37% ...

  20. Diversity of cultivated and metabolically active aerobic anoxygenic phototrophic bacteria along an oligotrophic gradient in the Mediterranean Sea

    Directory of Open Access Journals (Sweden)

    C. Jeanthon

    2011-07-01

    Full Text Available Aerobic anoxygenic phototrophic (AAP bacteria play significant roles in the bacterioplankton productivity and biogeochemical cycles of the surface ocean. In this study, we applied both cultivation and mRNA-based molecular methods to explore the diversity of AAP bacteria along an oligotrophic gradient in the Mediterranean Sea in early summer 2008. Colony-forming units obtained on three different agar media were screened for the production of bacteriochlorophyll-a (BChl-a, the light-harvesting pigment of AAP bacteria. BChl-a-containing colonies represented a low part of the cultivable fraction. In total, 54 AAP strains were isolated and the phylogenetic analyses based on their 16S rRNA and pufM genes showed that they were all affiliated to the Alphaproteobacteria. The most frequently isolated strains belonged to Citromicrobium bathyomarinum, and Erythrobacter and Roseovarius species. Most other isolates were related to species not reported to produce BChl-a and/or may represent novel taxa. Direct extraction of RNA from seawater samples enabled the analysis of the expression of pufM, the gene coding for the M subunit of the reaction centre complex of aerobic anoxygenic photosynthesis. Clone libraries of pufM gene transcripts revealed that most phylotypes were highly similar to sequences previously recovered from the Mediterranean Sea and a large majority (~94 % was affiliated to the Gammaproteobacteria. The most abundantly detected phylotypes occurred in the western and eastern Mediterranean basins. However, some were exclusively detected in the eastern basin, reflecting the highest diversity of pufM transcripts observed in this ultra-oligotrophic region. To our knowledge, this is the first study to document extensively the diversity of AAP isolates and to unveil the active AAP community in an oligotrophic marine environment. By pointing out the discrepancies

  1. Effects of the Adult Attachment Projective Picture System on oxytocin and cortisol blood levels in mothers

    Directory of Open Access Journals (Sweden)

    Sabrina Krause

    2016-12-01

    Full Text Available Oxytocin, a small neuropeptide of nine amino acids, has been characterized as the hormone of affiliation and is stimulated, for instance, in mothers when interacting with their offspring. Variations in maternal oxytocin levels were reported to predict differences in the quality of care provided by mothers. In this study, the Adult Attachment Projective Picture System (AAP as a valid measure to assess attachment representations was used as an activating attachment-related stimulus. We investigated whether the AAP induces a release of oxytocin in mothers with a secure attachment representation and a stress-related cortisol response in mothers with an insecure attachment representation. Therefore, pre-post effects of AAP administration on plasma oxytocin and serum cortisol levels were investigated in n = 44 mothers 3 months after parturition. Oxytocin levels increased from pre to post by the significant majority of 73% participants (p = .004 and cortisol decreased by the significant majority of 73% participants (p = .004. Interestingly, no association between alterations in oxytocin and cortisol were found; this suggests taking a model of two independent processes into considerations. These results show that the AAP test procedure induces an oxytocin response. Concerning the results within the four AAP representation subgroups, our hypothesis of a particularly strong increase in oxytocin in secure mothers was not confirmed; however, in secure mothers we observed a particularly strong decrease in cortisol, consistent with our hypotheses. Effect sizes are reported, allowing the replication of results in a larger study with sufficient sample size to draw final conclusions with respect to differences in OT and cortisol alterations depending on attachment representation. When interpreting the results, one should keep in mind that this study investigated lactating mothers. Thus, the generalizability of results is limited and future studies should

  2. Role of symbiotic auxotrophy in the Rhizobium-legume symbioses.

    Directory of Open Access Journals (Sweden)

    Jurgen Prell

    Full Text Available Rhizobium leguminosarum bv. viciae mutants unable to transport branched-chain amino acids via the two main amino acid ABC transport complexes AapJQMP and BraDEFGC produce a nitrogen starvation phenotype when inoculated on pea (Pisum sativum plants [1], [2]. Bacteroids in indeterminate pea nodules have reduced abundance and a lower chromosome number. They reduce transcription of pathways for branched-chain amino acid biosynthesis and become dependent on their provision by the host. This has been called "symbiotic auxotrophy".A region important in solute specificity was identified in AapQ and changing P144D in this region reduced branched-chain amino acid transport to a very low rate. Strains carrying P144D were still fully effective for N(2 fixation on peas demonstrating that a low rate of branched amino acid transport in R. leguminosarum bv. viciae supports wild-type rates of nitrogen fixation. The importance of branched-chain amino acid transport was then examined in other legume-Rhizobium symbioses. An aap bra mutant of R. leguminosarum bv. phaseoli also showed nitrogen starvation symptoms when inoculated on French bean (Phaseolus vulgaris, a plant producing determinate nodules. The phenotype is different from that observed on pea and is accompanied by reduced nodule numbers and nitrogen fixation per nodule. However, an aap bra double mutant of Sinorhizobium meliloti 2011 showed no phenotype on alfalfa (Medicago sativa.Symbiotic auxotrophy occurs in both determinate pea and indeterminate bean nodules demonstrating its importance for bacteroid formation and nodule function in legumes with different developmental programmes. However, only small quantities of branched chain amino acids are needed and symbiotic auxotrophy did not occur in the Sinorhizobium meliloti-alfalfa symbiosis under the conditions measured. The contrasting symbiotic phenotypes of aap bra mutants inoculated on different legumes probably reflects altered timing of amino acid

  3. Effects of the Adult Attachment Projective Picture System on Oxytocin and Cortisol Blood Levels in Mothers

    Science.gov (United States)

    Krause, Sabrina; Pokorny, Dan; Schury, Katharina; Doyen-Waldecker, Cornelia; Hulbert, Anna-Lena; Karabatsiakis, Alexander; Kolassa, Iris-Tatjana; Gündel, Harald; Waller, Christiane; Buchheim, Anna

    2016-01-01

    Oxytocin, a small neuropeptide of nine amino acids, has been characterized as the “hormone of affiliation” and is stimulated, for instance, in mothers when interacting with their offspring. Variations in maternal oxytocin levels were reported to predict differences in the quality of care provided by mothers. In this study, the Adult Attachment Projective Picture System (AAP) as a valid measure to assess attachment representations was used as an activating attachment-related stimulus. We investigated whether the AAP induces a release of oxytocin in mothers with a secure attachment representation and a stress-related cortisol response in mothers with an insecure attachment representation. Therefore, pre-post effects of AAP administration on plasma oxytocin and serum cortisol levels were investigated in n = 44 mothers 3 months after parturition. Oxytocin levels increased from pre to post in the significant majority of 73% participants (p = 0.004) and cortisol decreased in the significant majority of 73% participants (p = 0.004). Interestingly, no association between alterations in oxytocin and cortisol were found; this suggests taking a model of two independent processes into considerations. These results show that the AAP test procedure induces an oxytocin response. Concerning the results within the four AAP representation subgroups, our hypothesis of a particularly strong increase in oxytocin in secure mothers was not confirmed; however, in secure mothers we observed a particularly strong decrease in cortisol. Effect sizes are reported, allowing the replication of results in a larger study with sufficient sample size to draw final conclusions with respect to differences in OT and cortisol alterations depending on attachment representation. When interpreting the results, one should keep in mind that this study investigated lactating mothers. Thus, the generalizability of results is limited and future studies should investigate non-lactating healthy females as

  4. Clinical diagnosis and treatment of asparaginase associated pancreatitis in adults%成人门冬酶相关胰腺炎的临床诊治

    Institute of Scientific and Technical Information of China (English)

    李梦洁; 何牧卿; 沈益民

    2015-01-01

    目的 探讨成人门冬酶相关胰腺炎(AAP)的临床特点及诊治过程,旨在提高AAP诊治水平.方法 回顾性分析2009年1月至2015年6月间浙江医院血液内科及温州医科大学附属第二医院血液科收治的384例急性淋巴细胞白血病(ALL)患者的临床资料,所有患者均给予含培门冬酶或左旋门冬酰胺酶(L-asp)的多药联合化疗,分析AAP的发生情况、临床表现、诊断、治疗及转归.结果 384例ALL患者中18例发生AAP,发生率为4.7%,其中轻症AAP (MAAP) 13例,重症AAP(SAAP)5例.16例AAP发生在诱导化疗期,2例发生在维持强化期.腹痛为主要临床表现,血淀粉酶及脂肪酶活性均升高.治疗后,MAAP患者的腹痛症状缓解,血淀粉酶及脂肪酶活性明显下降,继续使用培门冬酶或L-asp化疗,未见胰腺炎复发.5例SAAP患者血淀粉酶及脂肪酶反复升高,其中1例因合并重症感染及囊肿破裂出血而病死.结论 成人ALL患者在门冬酶化疗期间出现腹痛症状应考虑AAP可能,加强血淀粉酶及脂肪酶检测,辅以B超和CT检查有助于早期诊治AAP,并改善患者预后.%Objective To investigate the clinical characteristics and the course of diagnosis and therapy of asparaginase associated pancreatitis (AAP) in adults, in order to improve the ability of diagnosis and treatment.Methods Data of 384 cases of acute lymphoblastic leukemia (ALL) who received treatment in Department of Hematology, Zhejiang Hospital, and Department of Hematology, Second Hospital Affiliated to Wenzhou Medical University from January 2009 to June 2015 was retrospectively analyzed.All patients were given multi-drug chemotherapy including PEG-asparaginase or L-asparaginase, the incidence of AAP, clinical manifestations, diagnosis, treatment and prognosis were analyzed.Results Among the 384 cases, 18 patients developed AAP, and the incidence of AAP was 4.7%, including 13 cases of mild AAP (MAAP), 5 cases of severe AAP (SAAP).Sixteen cases of

  5. 门冬酰胺酶相关儿童急性胰腺炎诊治研究进展%Progress of diagnosis and treatment of asparaginase associated pancreatitis in children

    Institute of Scientific and Technical Information of China (English)

    石苇

    2016-01-01

    门冬酰胺酶(ASP)是儿童急性淋巴细胞白血病和非霍奇金淋巴瘤联合化疗方案中的关键药物之一.ASP相关急性胰腺炎(AAP)是ASP的主要严重不良反应.现通过复习有关儿童AAP的近年国内外文献和我国《培门冬酶治疗急性淋巴细胞白血病和恶性淋巴瘤的专家共识》,以及对网络收集的历年来我国儿童AAP报道资料进行归纳与统计分析,参照国际AAP诊断标准,提出儿童AAP流行病学、临床表现、早期诊断和有效治疗要点,以及左旋门冬酰胺酶和培门冬酶的AAP临床对比.全文资料数据详尽,分析归纳依据充分,相关经验的临床可操作性强,对临床有效诊治儿童AAP具有较大的参考价值.%Asparaginase(ASP) is an important drug in the treatment of childhood acute lymphoblastic leukemia and non-Hodgkin lymphoma.Asparaginase associated pancreatitis (AAP) is the main treatment-adverse events of asparaginase.After reviewing the recent foreign literatures about AAP and the Chinese expert about polyethylene glycol conjugated asparaginase (PEG-ASP) in the treatment of acute lymphoblastic leukemia and malignant lymphoma with asparaginase,conclude and analysis the data about childhood AAP and show the epidemiology,clinical features,early diagnosis and effective treatment of children with AAP.Make clinical compare of L-asparaginase and PEG-ASP.Based on the full grasp of the relevant data,analyzing,introducing and integrating,this may be helpful to the diagnosis and treatment of childhood AAP.

  6. Surveying college introductory physics students’ attitudes and approaches to problem solving

    Science.gov (United States)

    Mason, Andrew J.; Singh, Chandralekha

    2016-09-01

    Students’ attitudes and approaches to problem solving in physics can greatly impact their actual problem solving practices and also influence their motivation to learn and ultimately the development of expertise. We developed and validated an attitudes and approaches to problem solving (AAPS) survey and administered it to students in the introductory physics courses in a typical large research university in the US. Here, we discuss the development and validation of the survey and analysis of the student responses to the survey questions in introductory physics courses. The introductory physics students’ responses to the survey questions were also compared with those of physics faculty members and physics PhD students. We find that introductory students are in general less expert-like than the physics faculty members and PhD students. Moreover, on some AAPS survey questions, the responses of students and faculty have unexpected trends. Those trends were interpreted via individual interviews, which helped clarify reasons for those survey responses.

  7. Resolution of alliance ruptures: The special case of animal-assisted psychotherapy.

    Science.gov (United States)

    Zilcha-Mano, Sigal

    2017-01-01

    Many therapists regard alliance ruptures as one of the greatest challenges therapists face in the therapy room. Alliance ruptures has been previously defined as breakdowns in the process of negotiation of treatment tasks and goals and a deterioration in the affective bond between patient and therapist. Alliance ruptures have been found to predict premature termination of treatment and poor treatment outcomes. But ruptures can also present important opportunities for gaining insight and awareness and for facilitating therapeutic change. A process of rupture resolution may lead to beneficial outcomes and serve as a corrective emotional experience. The article describes unique processes of alliance rupture resolution inherent in animal-assisted psychotherapy (AAP). Building on Safran and Muran's model and on clinical examples, the article describes strategies for identifying ruptures in AAP and techniques for repairing them to facilitate a corrective experience in treatment. Implications for clinical practice and future research are discussed.

  8. Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms.

    Science.gov (United States)

    Conrady, Deborah G; Wilson, Jeffrey J; Herr, Andrew B

    2013-01-15

    Staphylococcal bacteria, including Staphylococcus epidermidis and Staphylococcus aureus, cause chronic biofilm-related infections. The homologous proteins Aap and SasG mediate biofilm formation in S. epidermidis and S. aureus, respectively. The self-association of these proteins in the presence of Zn(2+) leads to the formation of extensive adhesive contacts between cells. This study reports the crystal structure of a Zn(2+) -bound construct from the self-associating region of Aap. Several unusual structural features include elongated β-sheets that are solvent-exposed on both faces and the lack of a canonical hydrophobic core. Zn(2+)-dependent dimers are observed in three distinct crystal forms, formed via pleomorphic coordination of Zn(2+) in trans across the dimer interface. These structures illustrate how a long, flexible surface protein is able to form tight intercellular adhesion sites under adverse environmental conditions.

  9. Binding and conformational changes of human serum albumin upon interaction with 4-aminoantipyrine studied by spectroscopic methods and cyclic voltammetry.

    Science.gov (United States)

    Gowda, Jayant I; Nandibewoor, Sharanappa T

    2014-04-24

    The interactions of 4-aminoantipyrine (AAP) with human serum albumin (HSA) have been studied by UV-visible spectroscopy, fluorescence spectroscopy and cyclic voltammetry. The binding of 4-aminoantipyrine quenches the HSA fluorescence, revealing a 1:1 interaction with a binding constant of about 10(5) M(-1). The experimental results showed that AAP effectively quenched the intrinsic fluorescence of HSA via dynamic type of quenching. In addition, according to the synchronous fluorescence spectra of HSA in presence of 4-aminoantipyrine, the tryptophan residue of the proteins are most perturbed by the binding process. The number of binding sites, the binding constant, site probe study, some common metal ions effect and the thermodynamic parameters were calculated.

  10. From porous gold nanocups to porous nanospheres and solid particles - A new synthetic approach

    KAUST Repository

    Ihsan, Ayesha

    2015-05-01

    We report a versatile approach for the synthesis of porous gold nanocups, porous gold nanospheres and solid gold nanoparticles. Gold nanocups are formed by the slow reduction of gold salt (HAuCl4{dot operator}3H2O) using aminoantipyrene (AAP) as a reducing agent. Adding polyvinylpyrrolidone (PVP) to the gold salt followed by reduction with AAP resulted in the formation of porous gold nanospheres. Microwave irradiation of both of these porous gold particles resulted in the formation of slightly smaller but solid gold particles. All these nanoparticles are thoroughly characterized by UV-visible spectroscopy, scanning electron microscopy (SEM), high resolution transmission electron microscopy (HR-TEM) and bright-field tomography. Due to the larger size, porous nature, low density and higher surface area, these nanomaterials may have interesting applications in catalysis, drug delivery, phototherapy and sensing.

  11. Level-2 Milestone 5588: Deliver Strategic Plan and Initial Scalability Assessment by Advanced Architecture and Portability Specialists Team

    Energy Technology Data Exchange (ETDEWEB)

    Draeger, Erik W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-09-30

    This report documents the fact that the work in creating a strategic plan and beginning customer engagements has been completed. The description of milestone is: The newly formed advanced architecture and portability specialists (AAPS) team will develop a strategic plan to meet the goals of 1) sharing knowledge and experience with code teams to ensure that ASC codes run well on new architectures, and 2) supplying skilled computational scientists to put the strategy into practice. The plan will be delivered to ASC management in the first quarter. By the fourth quarter, the team will identify their first customers within PEM and IC, perform an initial assessment and scalability and performance bottleneck for next-generation architectures, and embed AAPS team members with customer code teams to assist with initial portability development within standalone kernels or proxy applications.

  12. Dicty_cDB: Contig-U16439-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available brary AT0AA from... 44 1e-04 3 ( CU574825 ) Theobroma cacao, mRNA sequence (KZ0AAP12YP24FM1). 48 1e-04 2 ( E... 0.026 2 ( CU575425 ) Theobroma cacao, mRNA sequence (KZ0AAP24YN23FM1). 40 0.028 2 ( ES792413 ) UFL_529_13 C...-FP_174156 WHMH (pink hibiscus mealybug) Maco... 52 0.14 1 ( CU601157 ) Theobroma cacao, mRNA sequence (KZ0A...AG4YA23FM1). 52 0.14 1 ( CU517752 ) Theobroma cacao, mRNA sequence (KZ0ABH13YA11F...M1). 52 0.14 1 ( CU485450 ) Theobroma cacao, mRNA sequence (KZ0ACAC4YK21FM1). 52 0.14 1 ( BU714316 ) SJAACBH

  13. Asymmetric dimethylarginine in somatically healthy schizophrenia patients treated with atypical antipsychotics

    DEFF Research Database (Denmark)

    Jørgensen, Anders; Knorr, Ulla Benedichte Søsted; Soendergaard, Mia Greisen;

    2015-01-01

    and the L-arginine:ADMA ratio showed no correlations with oxidative stress markers, medication load, or Positive and Negative Syndrome Scale scores. CONCLUSIONS: Schizophrenia and treatment with AAP was not associated with increased levels of plasma ADMA or the L-arginine:ADMA ratio. Furthermore, plasma......BACKGROUND: Schizophrenia is associated with increased cardiovascular morbidity and mortality. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of the nitric oxide synthase, and the L-arginine:ADMA ratio are markers of endothelial dysfunction that predict mortality and adverse outcome...... in a range of cardiovascular disorders. Increased ADMA levels may also lead to increased oxidative stress. We hypothesized that ADMA and the L-arginine:ADMA ratio are increased in somatically healthy schizophrenia patients treated with atypical antipsychotics (AAP), and that the ADMA and the L-arginine: ADMA...

  14. Surveying college introductory physics students' attitudes and approaches to problem solving

    CERN Document Server

    Mason, Andrew

    2016-01-01

    Students' attitudes and approaches to problem solving in physics can greatly impact their actual problem solving practices and also influence their motivation to learn and ultimately the development of expertise. We developed and validated an attitudes and approaches to problem solving (AAPS) survey and administered it to students in the introductory physics courses in a typical large research university in the US. Here, we discuss the development and validation of the survey and analysis of the student responses to the survey questions in introductory physics courses. The introductory physics students' responses to the survey questions were also compared with those of physics faculty members and physics PhD students. We find that introductory students are in general less expert-like than the physics faculty members and PhD students. Moreover, on some AAPS survey questions, the responses of students and faculty have unexpected trends. Those trends were interpreted via in

  15. Surveying Turkish high school and university student attitudes and approaches to physics problem solving

    CERN Document Server

    Balta, Nuri; Singh, Chandralekha

    2016-01-01

    Student attitudes and approaches to problem solving can impact how well they learn physics. Prior research in the US using a validated Attitude and Approaches to Problem Solving (AAPS) survey suggests that there are major differences between students in introductory physics and astronomy courses and physics experts in terms of their attitudes and approaches to physics problem solving. Here we discuss the validation, administration and analysis of data for the Turkish version of the AAPS survey for high school and university students in Turkey. After the validation and administration of the Turkish version of the survey, the analysis of the data was conducted by grouping the data by grade level, school type, and gender. While there are no statistically significant differences between the averages of various groups on the survey, overall, the university students in Turkey were more expert-like than vocational high school students. On an item by item basis, there are statistically differences between the average...

  16. Anorexia and Attachment: Dysregulated Defense and Pathological Mourning

    Directory of Open Access Journals (Sweden)

    elisa edelvecchio

    2014-10-01

    Full Text Available The role of Defensive exclusion (Deactivation and Segregated Systems in the development of early relationships and related to subsequent manifestations of symptoms of eating disorders was assessed using the Adult Attachment Projective Picture System (AAP. Fifty-one DSM-IV diagnosed women with anorexia participated in the study. Anorexic patients were primarily classified as dismissing or unresolved. Quantitative and qualitative analyses of defensive exclusion were carried out. Results showed potential benefits of using the AAP defense exclusion coding system, in addition to the main attachment classifications, in order to better understand the developmental issues involved in anorexia. Discussion concerned the processes, such as pathological mourning, that may underlie the associations between dismissing and unresolved attachment and anorexia. Implications for developmental research and clinical nosology are discussed.

  17. Application of acid-treated yeast cell wall (AYC) as a pharmaceutical additive. II: effects of curing on the medicine release from AYC-coated tablets.

    Science.gov (United States)

    Yuasa, H; Kaneshige, J; Ozeki, T; Kasai, T; Eguchi, T; Ishiwaki, N

    2000-11-19

    Acid-treated yeast cell wall (AYC) was newly prepared by acidifying brewers' yeast cell wall. Core tablets containing 3% of acetaminophen (AAP) were coated with the AYC aqueous dispersion containing 5% (w/v) of AYC and 0.35% (w/v) of glycerol. The curing of AYC-coated tablets was performed at various curing periods of time and temperatures. The effects of curing on AAP release from AYC-coated tablets, the weight and thickness of the coated layer of AYC and the water sorption into the AYC-coated tablets were studied. The tensile strength and pore size distribution of the AYC cast film were measured. In the case of 60, 80, or 100 degrees C curing, AAP release from AYC-coated tablets showed a sigmoidal release profile with an initial lag time. The duration of the lag time increased with the increasing curing time and temperature, though the release rate after the lag time hardly changed. At 120 degrees C curing, the release rate after the lag time decreased with the increasing curing time and a sustained release was observed. The weight and thickness of the AYC-coated layer and the water sorption rate into AYC-coated tablets decreased with the increasing curing time and temperature. The tensile strength of the AYC cast film increased with increasing the curing temperature, particularly at 120 degrees C curing. It is considered that the water was evaporated from the AYC-coated layer and the adhesion force between AYC particles increased during curing, making the structure of the AYC-coated layer densely firm. The changes in the duration of lag time and the release rate may be due to changes in the structure of the AYC-coated layer caused by curing. These results show that it is feasible to control the lag time and the release rate of AAP from AYC-coated tablets by varying the curing time and temperature.

  18. Comparison of growth rates of aerobic anoxygenic phototrophic bacteria and other bacterioplankton groups in coastal Mediterranean waters.

    Science.gov (United States)

    Ferrera, Isabel; Gasol, Josep M; Sebastián, Marta; Hojerová, Eva; Koblízek, Michal

    2011-11-01

    Growth is one of the basic attributes of any living organism. Surprisingly, the growth rates of marine bacterioplankton are only poorly known. Current data suggest that marine bacteria grow relatively slowly, having generation times of several days. However, some bacterial groups, such as the aerobic anoxygenic phototrophic (AAP) bacteria, have been shown to grow much faster. Two manipulation experiments, in which grazing, viruses, and resource competition were reduced, were conducted in the coastal Mediterranean Sea (Blanes Bay Microbial Observatory). The growth rates of AAP bacteria and of several important phylogenetic groups (the Bacteroidetes, the alphaproteobacterial groups Roseobacter and SAR11, and the Gammaproteobacteria group and its subgroups the Alteromonadaceae and the NOR5/OM60 clade) were calculated from changes in cell numbers in the manipulation treatments. In addition, we examined the role that top-down (mortality due to grazers and viruses) and bottom-up (resource availability) factors play in determining the growth rates of these groups. Manipulations resulted in an increase of the growth rates of all groups studied, but its extent differed largely among the individual treatments and among the different groups. Interestingly, higher growth rates were found for the AAP bacteria (up to 3.71 day⁻¹) and for the Alteromonadaceae (up to 5.44 day⁻¹), in spite of the fact that these bacterial groups represented only a very low percentage of the total prokaryotic community. In contrast, the SAR11 clade, which was the most abundant group, was the slower grower in all treatments. Our results show that, in general, the least abundant groups exhibited the highest rates, whereas the most abundant groups were those growing more slowly, indicating that some minor groups, such the AAP bacteria, very likely contribute much more to the recycling of organic matter in the ocean than what their abundances alone would predict.

  19. Children of Military Service Members Resource Guide

    Science.gov (United States)

    2012-01-01

    www.aap.org developed by military pediatricians and adolescent- medicine specialists, this animated film, hosted by mr. poe, is designed to provide...reported missing in action in vietnam. dove song K.L. Franklin Publisher: Prometheus Books Year: 2007 isbN: 978-1591025344 Pages: 56 this book...adolescent- medicine specialists, this film is designed for older children and adolescents to help them learn coping strategies for dealing with

  20. Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide

    OpenAIRE

    2010-01-01

    Specific regulatory nascent chains establish direct interactions with the ribosomal tunnel, leading to translational stalling. Despite a wealth of biochemical data, structural insight into the mechanism of translational stalling in eukaryotes is still lacking. Here we use cryo-electron microscopy to visualize eukaryotic ribosomes stalled during the translation of two diverse regulatory peptides: the fungal arginine attenuator peptide (AAP) and the human cytomegalovirus (hCMV) gp48 upstream op...

  1. A Reassessment of the SIDS Back to Sleep Campaign

    Directory of Open Access Journals (Sweden)

    Ralph Pelligra

    2005-01-01

    Full Text Available The Back to Sleep Campaign was initiated in 1994 to implement the American Academy of Pediatrics' (AAP recommendation that infants be placed in the nonprone sleeping position to reduce the risk of the Sudden Infant Death Syndrome (SIDS. This paper offers a challenge to the Back to Sleep Campaign (BTSC from two perspectives: (1 the questionable validity of SIDS mortality and risk statistics, and (2 the BTSC as human experimentation rather than as confirmed preventive therapy.

  2. Improving validated depression screen among adolescent population in primary care practice using electronic health records (EHR).

    OpenAIRE

    2015-01-01

    Adolescent depression, has been identified as one of the important risk factors for adolescent safety. The American Academy of Pediatrics (AAP) recommends screening the adolescent population for depression with a validated screening tool at least once a year. Given the time constraints in primary care, many physicians tend to rely more on clinical questioning to screen depression.This has the potential to miss many adolescents who may have mild to moderate depression which may prove detriment...

  3. Role of Symbiotic Auxotrophy in the Rhizobium-Legume Symbioses

    OpenAIRE

    Jurgen Prell; Alexandre Bourdès; Shalini Kumar; Emma Lodwig; Arthur Hosie; Seonag Kinghorn; James White; Philip Poole

    2010-01-01

    Background Rhizobium leguminosarum bv. viciae mutants unable to transport branched-chain amino acids via the two main amino acid ABC transport complexes AapJQMP and BraDEFGC produce a nitrogen starvation phenotype when inoculated on pea (Pisum sativum) plants [1], [2]. Bacteroids in indeterminate pea nodules have reduced abundance and a lower chromosome number. They reduce transcription of pathways for branched-chain amino acid biosynthesis and become dependent on their provision by the host....

  4. NCBI nr-aa BLAST: CBRC-FRUB-02-0117 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FRUB-02-0117 ref|NP_001075589.1| blood-brain barrier large neutral amino acid ...mall subunit 1 (L-type amino acid transporter 1) (4F2 light chain) (4F2 LC) (4F2LC) (LAT1 light chain) gb|AAP47189.1| blood-brain bar...rier large neutral amino acid transporter light chain [Oryctolagus cuniculus] NP_001075589.1 7e-70 61% ...

  5. Esiplaanil heli / Harri Slip

    Index Scriptorium Estoniae

    Slip, Harri

    2015-01-01

    Kõrvaklapid hinnaga alla 200 €: AKG Y50BT, Audio-Technica, Beyerdynamic Custom Street, Bose SoundTrue around-ear II, Creative Aurvana Gold, Denon AH-MM200, Focal Spirit One S, Grado SR 80e, JBL Everest V300, Klipsch Reference On Ear, Panasonic RP-HD10, Philips SHB8850NC, Sennheiser HD 25, SMS Audio On-Ear Wired Sport, Sony MDR-100AAP

  6. AcEST: DK949530 [AcEST

    Lifescience Database Archive (English)

    Full Text Available dhesion molecule 1-B OS=Xenop... 32 4.1 sp|O59942|AAP2_NEUCR Amino-acid permease 2 OS=Neurospora crassa ... 32 4.1 sp|Q96685|VCO..... 31 7.0 sp|B1VII7|Y1611_CORU7 UPF0678 fatty acid-binding protein-like pr... 30 9.1 sp|Q65952|VCOM_ADECC Mi

  7. Detection of the Metabolic Syndrome in Schizophrenia and Implications for Antipsychotic Therapy: Is There a Role for Folate?

    OpenAIRE

    Burghardt, Kyle J; Ellingrod, Vicki L.

    2013-01-01

    In general, presence of the metabolic syndrome is associated with significant cardiovascular mortality and represents a growing public health concern in the United States. Patients with a schizophrenia have a three times greater risk of death compared to the general population, with cardiovascular disease being the most common cause of this mortality. Use of the atypical antipsychotics (AAPs) to treat schizophrenia contributes significantly to this cardiovascular disease risk. While currently...

  8. NCBI nr-aa BLAST: CBRC-PTRO-27-0250 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PTRO-27-0250 ref|NP_666507.1| olfactory receptor 1276 [Mus musculus] gb|AAL61363.1| olfactory... receptor MOR245-10 [Mus musculus] gb|AAP71670.1| olfactory receptor Olfr1276 [Mus musculus] emb|CAM27563.1| olfactory... receptor 1276 [Mus musculus] gb|EDL27803.1| olfactory receptor 1276 [Mus musculus] NP_666507.1 1e-116 69% ...

  9. NCBI nr-aa BLAST: CBRC-LAFR-01-4115 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-4115 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 1e-130 73% ...

  10. NCBI nr-aa BLAST: CBRC-CFAM-18-0207 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CFAM-18-0207 ref|NP_667192.1| olfactory receptor 1260 [Mus musculus] gb|AAL60770.1| olfactory... receptor MOR232-2 [Mus musculus] gb|AAP71654.1| olfactory receptor Olfr1260 [Mus musculus] emb|CAM27664.1| olfactory... receptor 1260 [Mus musculus] gb|EDL27466.1| olfactory receptor 1260 [Mus musculus] NP_667192.1 1e-148 84% ...

  11. NCBI nr-aa BLAST: CBRC-CJAC-01-0312 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CJAC-01-0312 ref|NP_666646.1| olfactory receptor 993 [Mus musculus] gb|AAL61326.1| olfactory... receptor MOR203-2 [Mus musculus] gb|AAP71451.1| olfactory receptor Olfr993 [Mus musculus] emb|CAM24030.1| olfactory... receptor 993 [Mus musculus] gb|EDL27327.1| olfactory receptor 993 [Mus musculus] NP_666646.1 1e-137 77% ...

  12. NCBI nr-aa BLAST: CBRC-STRI-01-0445 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-STRI-01-0445 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-118 69% ...

  13. NCBI nr-aa BLAST: CBRC-DNOV-01-0762 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-0762 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 1e-126 67% ...

  14. NCBI nr-aa BLAST: CBRC-LAFR-01-4023 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-4023 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-137 75% ...

  15. NCBI nr-aa BLAST: CBRC-RNOR-03-0025 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-03-0025 ref|NP_667161.1| olfactory receptor 341 [Mus musculus] gb|AAL60801.1| olfactory... receptor MOR136-2 [Mus musculus] gb|AAP70875.1| olfactory receptor Olfr341 [Mus musculus] emb|CAM20475.1| olfactory... receptor 341 [Mus musculus] gb|EDL08679.1| olfactory receptor 341 [Mus musculus] NP_667161.1 1e-150 84% ...

  16. NCBI nr-aa BLAST: CBRC-MMUS-02-0123 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0123 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 1e-154 87% ...

  17. NCBI nr-aa BLAST: CBRC-CJAC-01-0213 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CJAC-01-0213 ref|NP_667058.1| olfactory receptor 1090 [Mus musculus] gb|AAL60909.1| olfactory... receptor MOR188-4 [Mus musculus] gb|AAP71517.1| olfactory receptor Olfr1090 [Mus musculus] emb|CAM24652.1| olfactory... receptor 1090 [Mus musculus] gb|EDL27371.1| olfactory receptor 1090 [Mus musculus] NP_667058.1 1e-140 77% ...

  18. NCBI nr-aa BLAST: CBRC-RNOR-03-0217 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-03-0217 ref|NP_667047.1| olfactory receptor 1132 [Mus musculus] gb|AAL60920.1| olfactory... receptor MOR177-1 [Mus musculus] gb|AAP71551.1| olfactory receptor Olfr1132 [Mus musculus] emb|CAM25126.1| olfactory... receptor 1132 [Mus musculus] gb|EDL27401.1| olfactory receptor 1132 [Mus musculus] NP_667047.1 1e-153 88% ...

  19. NCBI nr-aa BLAST: CBRC-MEUG-01-0090 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MEUG-01-0090 ref|NP_666644.1| olfactory receptor 994 [Mus musculus] gb|AAL61328.1| olfactory... receptor MOR203-4 [Mus musculus] gb|AAP71452.1| olfactory receptor Olfr994 [Mus musculus] emb|CAM24031.1| olfactory... receptor 994 [Mus musculus] gb|EDL27328.1| olfactory receptor 994 [Mus musculus] NP_666644.1 2e-30 65% ...

  20. NCBI nr-aa BLAST: CBRC-PCAP-01-1410 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PCAP-01-1410 ref|NP_667151.1| olfactory receptor 352 [Mus musculus] gb|AAL60811.1| olfactory... receptor MOR136-10 [Mus musculus] gb|AAP70886.1| olfactory receptor Olfr352 [Mus musculus] emb|CAM16518.1| olfactory... receptor 352 [Mus musculus] gb|EDL08690.1| olfactory receptor 352 [Mus musculus] NP_667151.1 1e-134 78% ...

  1. NCBI nr-aa BLAST: CBRC-EEUR-01-1536 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-1536 ref|NP_667122.1| olfactory receptor 1377 [Mus musculus] gb|AAL60840.1| olfactory... receptor MOR129-1 [Mus musculus] gb|AAP71759.1| olfactory receptor Olfr1377 [Mus musculus] emb|CAI35307.1| olfactory... receptor 1377 [Mus musculus] gb|EDL33683.1| olfactory receptor 1377 [Mus musculus] NP_667122.1 4e-78 76% ...

  2. NCBI nr-aa BLAST: CBRC-TBEL-01-0332 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TBEL-01-0332 ref|NP_666507.1| olfactory receptor 1276 [Mus musculus] gb|AAL61363.1| olfactory... receptor MOR245-10 [Mus musculus] gb|AAP71670.1| olfactory receptor Olfr1276 [Mus musculus] emb|CAM27563.1| olfactory... receptor 1276 [Mus musculus] gb|EDL27803.1| olfactory receptor 1276 [Mus musculus] NP_666507.1 1e-98 77% ...

  3. NCBI nr-aa BLAST: CBRC-FCAT-01-0108 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FCAT-01-0108 ref|NP_667047.1| olfactory receptor 1132 [Mus musculus] gb|AAL60920.1| olfactory... receptor MOR177-1 [Mus musculus] gb|AAP71551.1| olfactory receptor Olfr1132 [Mus musculus] emb|CAM25126.1| olfactory... receptor 1132 [Mus musculus] gb|EDL27401.1| olfactory receptor 1132 [Mus musculus] NP_667047.1 4e-59 77% ...

  4. NCBI nr-aa BLAST: CBRC-DNOV-01-1203 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-1203 ref|NP_667192.1| olfactory receptor 1260 [Mus musculus] gb|AAL60770.1| olfactory... receptor MOR232-2 [Mus musculus] gb|AAP71654.1| olfactory receptor Olfr1260 [Mus musculus] emb|CAM27664.1| olfactory... receptor 1260 [Mus musculus] gb|EDL27466.1| olfactory receptor 1260 [Mus musculus] NP_667192.1 1e-130 74% ...

  5. NCBI nr-aa BLAST: CBRC-TBEL-01-0145 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TBEL-01-0145 ref|NP_666644.1| olfactory receptor 994 [Mus musculus] gb|AAL61328.1| olfactory... receptor MOR203-4 [Mus musculus] gb|AAP71452.1| olfactory receptor Olfr994 [Mus musculus] emb|CAM24031.1| olfactory... receptor 994 [Mus musculus] gb|EDL27328.1| olfactory receptor 994 [Mus musculus] NP_666644.1 1e-103 77% ...

  6. NCBI nr-aa BLAST: CBRC-EEUR-01-0525 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-0525 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-125 69% ...

  7. NCBI nr-aa BLAST: CBRC-DNOV-01-3176 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-3176 ref|NP_667192.1| olfactory receptor 1260 [Mus musculus] gb|AAL60770.1| olfactory... receptor MOR232-2 [Mus musculus] gb|AAP71654.1| olfactory receptor Olfr1260 [Mus musculus] emb|CAM27664.1| olfactory... receptor 1260 [Mus musculus] gb|EDL27466.1| olfactory receptor 1260 [Mus musculus] NP_667192.1 1e-136 76% ...

  8. NCBI nr-aa BLAST: CBRC-SARA-01-0675 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SARA-01-0675 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-136 76% ...

  9. NCBI nr-aa BLAST: CBRC-ETEL-01-0259 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0259 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 2e-67 69% ...

  10. NCBI nr-aa BLAST: CBRC-EEUR-01-0625 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-0625 ref|NP_667047.1| olfactory receptor 1132 [Mus musculus] gb|AAL60920.1| olfactory... receptor MOR177-1 [Mus musculus] gb|AAP71551.1| olfactory receptor Olfr1132 [Mus musculus] emb|CAM25126.1| olfactory... receptor 1132 [Mus musculus] gb|EDL27401.1| olfactory receptor 1132 [Mus musculus] NP_667047.1 1e-135 75% ...

  11. NCBI nr-aa BLAST: CBRC-MMUS-02-0041 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0041 ref|NP_666480.1| olfactory receptor 361 [Mus musculus] gb|AAL61388.1| olfactory... receptor MOR159-3 [Mus musculus] gb|AAP70894.1| olfactory receptor Olfr361 [Mus musculus] emb|CAM20133.1| olfactory... receptor 361 [Mus musculus] gb|EDL08698.1| olfactory receptor 361 [Mus musculus] NP_666480.1 1e-142 84% ...

  12. NCBI nr-aa BLAST: CBRC-BTAU-01-2747 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-2747 ref|NP_666646.1| olfactory receptor 993 [Mus musculus] gb|AAL61326.1| olfactory... receptor MOR203-2 [Mus musculus] gb|AAP71451.1| olfactory receptor Olfr993 [Mus musculus] emb|CAM24030.1| olfactory... receptor 993 [Mus musculus] gb|EDL27327.1| olfactory receptor 993 [Mus musculus] NP_666646.1 1e-133 76% ...

  13. NCBI nr-aa BLAST: CBRC-BTAU-01-0079 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-0079 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-137 75% ...

  14. NCBI nr-aa BLAST: CBRC-RNOR-03-0146 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-03-0146 ref|NP_667058.1| olfactory receptor 1090 [Mus musculus] gb|AAL60909.1| olfactory... receptor MOR188-4 [Mus musculus] gb|AAP71517.1| olfactory receptor Olfr1090 [Mus musculus] emb|CAM24652.1| olfactory... receptor 1090 [Mus musculus] gb|EDL27371.1| olfactory receptor 1090 [Mus musculus] NP_667058.1 1e-145 80% ...

  15. NCBI nr-aa BLAST: CBRC-BTAU-01-0928 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-0928 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-123 71% ...

  16. NCBI nr-aa BLAST: CBRC-RNOR-10-0083 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-10-0083 ref|NP_667122.1| olfactory receptor 1377 [Mus musculus] gb|AAL60840.1| olfactory... receptor MOR129-1 [Mus musculus] gb|AAP71759.1| olfactory receptor Olfr1377 [Mus musculus] emb|CAI35307.1| olfactory... receptor 1377 [Mus musculus] gb|EDL33683.1| olfactory receptor 1377 [Mus musculus] NP_667122.1 2e-98 73% ...

  17. NCBI nr-aa BLAST: CBRC-MMUS-02-0023 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0023 ref|NP_667161.1| olfactory receptor 341 [Mus musculus] gb|AAL60801.1| olfactory... receptor MOR136-2 [Mus musculus] gb|AAP70875.1| olfactory receptor Olfr341 [Mus musculus] emb|CAM20475.1| olfactory... receptor 341 [Mus musculus] gb|EDL08679.1| olfactory receptor 341 [Mus musculus] NP_667161.1 1e-177 100% ...

  18. NCBI nr-aa BLAST: CBRC-PABE-12-0068 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PABE-12-0068 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 1e-139 81% ...

  19. NCBI nr-aa BLAST: CBRC-DNOV-01-0016 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-0016 ref|NP_667088.1| olfactory receptor 1395 [Mus musculus] gb|AAL60876.1| olfactory... receptor MOR277-1 [Mus musculus] gb|AAP71777.1| olfactory receptor Olfr1395 [Mus musculus] emb|CAM46261.1| olfactory... receptor 1395 [Mus musculus] gb|EDL33774.1| olfactory receptor 1395 [Mus musculus] NP_667088.1 1e-127 87% ...

  20. NCBI nr-aa BLAST: CBRC-DNOV-01-2646 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-2646 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 1e-117 73% ...

  1. NCBI nr-aa BLAST: CBRC-LAFR-01-1224 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-1224 ref|NP_667151.1| olfactory receptor 352 [Mus musculus] gb|AAL60811.1| olfactory... receptor MOR136-10 [Mus musculus] gb|AAP70886.1| olfactory receptor Olfr352 [Mus musculus] emb|CAM16518.1| olfactory... receptor 352 [Mus musculus] gb|EDL08690.1| olfactory receptor 352 [Mus musculus] NP_667151.1 1e-130 81% ...

  2. NCBI nr-aa BLAST: CBRC-OPRI-01-0959 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OPRI-01-0959 ref|NP_666854.1| olfactory receptor 1155 [Mus musculus] gb|AAL61117.1| olfactory... receptor MOR174-10 [Mus musculus] gb|AAP71568.1| olfactory receptor Olfr1155 [Mus musculus] emb|CAM18637.1| olfactory... receptor 1155 [Mus musculus] gb|EDL27414.1| olfactory receptor 1155 [Mus musculus] NP_666854.1 2e-79 56% ...

  3. NCBI nr-aa BLAST: CBRC-EEUR-01-1434 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-1434 ref|NP_666507.1| olfactory receptor 1276 [Mus musculus] gb|AAL61363.1| olfactory... receptor MOR245-10 [Mus musculus] gb|AAP71670.1| olfactory receptor Olfr1276 [Mus musculus] emb|CAM27563.1| olfactory... receptor 1276 [Mus musculus] gb|EDL27803.1| olfactory receptor 1276 [Mus musculus] NP_666507.1 4e-49 82% ...

  4. NCBI nr-aa BLAST: CBRC-LAFR-01-1124 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-1124 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-136 75% ...

  5. NCBI nr-aa BLAST: CBRC-PHAM-01-0915 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PHAM-01-0915 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-147 82% ...

  6. NCBI nr-aa BLAST: CBRC-ETEL-01-0986 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0986 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 2e-84 65% ...

  7. NCBI nr-aa BLAST: CBRC-EEUR-01-0091 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-0091 ref|NP_667151.1| olfactory receptor 352 [Mus musculus] gb|AAL60811.1| olfactory... receptor MOR136-10 [Mus musculus] gb|AAP70886.1| olfactory receptor Olfr352 [Mus musculus] emb|CAM16518.1| olfactory... receptor 352 [Mus musculus] gb|EDL08690.1| olfactory receptor 352 [Mus musculus] NP_667151.1 2e-70 75% ...

  8. NCBI nr-aa BLAST: CBRC-OCUN-01-0578 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OCUN-01-0578 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 1e-154 90% ...

  9. NCBI nr-aa BLAST: CBRC-SARA-01-1437 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SARA-01-1437 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-123 71% ...

  10. NCBI nr-aa BLAST: CBRC-LAFR-01-4104 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-4104 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 1e-135 76% ...

  11. NCBI nr-aa BLAST: CBRC-LAFR-01-0651 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0651 ref|NP_666854.1| olfactory receptor 1155 [Mus musculus] gb|AAL61117.1| olfactory... receptor MOR174-10 [Mus musculus] gb|AAP71568.1| olfactory receptor Olfr1155 [Mus musculus] emb|CAM18637.1| olfactory... receptor 1155 [Mus musculus] gb|EDL27414.1| olfactory receptor 1155 [Mus musculus] NP_666854.1 1e-123 72% ...

  12. NCBI nr-aa BLAST: CBRC-LAFR-01-4099 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-4099 ref|NP_666854.1| olfactory receptor 1155 [Mus musculus] gb|AAL61117.1| olfactory... receptor MOR174-10 [Mus musculus] gb|AAP71568.1| olfactory receptor Olfr1155 [Mus musculus] emb|CAM18637.1| olfactory... receptor 1155 [Mus musculus] gb|EDL27414.1| olfactory receptor 1155 [Mus musculus] NP_666854.1 1e-112 66% ...

  13. NCBI nr-aa BLAST: CBRC-LAFR-01-3900 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-3900 ref|NP_667047.1| olfactory receptor 1132 [Mus musculus] gb|AAL60920.1| olfactory... receptor MOR177-1 [Mus musculus] gb|AAP71551.1| olfactory receptor Olfr1132 [Mus musculus] emb|CAM25126.1| olfactory... receptor 1132 [Mus musculus] gb|EDL27401.1| olfactory receptor 1132 [Mus musculus] NP_667047.1 1e-135 78% ...

  14. NCBI nr-aa BLAST: CBRC-GGOR-01-0347 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GGOR-01-0347 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 2e-69 81% ...

  15. NCBI nr-aa BLAST: CBRC-CPOR-01-1606 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CPOR-01-1606 ref|NP_666644.1| olfactory receptor 994 [Mus musculus] gb|AAL61328.1| olfactory... receptor MOR203-4 [Mus musculus] gb|AAP71452.1| olfactory receptor Olfr994 [Mus musculus] emb|CAM24031.1| olfactory... receptor 994 [Mus musculus] gb|EDL27328.1| olfactory receptor 994 [Mus musculus] NP_666644.1 1e-140 79% ...

  16. NCBI nr-aa BLAST: CBRC-STRI-01-0227 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-STRI-01-0227 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 1e-146 85% ...

  17. NCBI nr-aa BLAST: CBRC-PCAP-01-1510 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PCAP-01-1510 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-117 69% ...

  18. NCBI nr-aa BLAST: CBRC-RNOR-10-0087 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-10-0087 ref|NP_667122.1| olfactory receptor 1377 [Mus musculus] gb|AAL60840.1| olfactory... receptor MOR129-1 [Mus musculus] gb|AAP71759.1| olfactory receptor Olfr1377 [Mus musculus] emb|CAI35307.1| olfactory... receptor 1377 [Mus musculus] gb|EDL33683.1| olfactory receptor 1377 [Mus musculus] NP_667122.1 1e-155 86% ...

  19. NCBI nr-aa BLAST: CBRC-OLAT-18-0035 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OLAT-18-0035 ref|NP_667161.1| olfactory receptor 341 [Mus musculus] gb|AAL60801.1| olfactory... receptor MOR136-2 [Mus musculus] gb|AAP70875.1| olfactory receptor Olfr341 [Mus musculus] emb|CAM20475.1| olfactory... receptor 341 [Mus musculus] gb|EDL08679.1| olfactory receptor 341 [Mus musculus] NP_667161.1 4e-04 24% ...

  20. NCBI nr-aa BLAST: CBRC-RNOR-03-0168 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-03-0168 ref|NP_667058.1| olfactory receptor 1090 [Mus musculus] gb|AAL60909.1| olfactory... receptor MOR188-4 [Mus musculus] gb|AAP71517.1| olfactory receptor Olfr1090 [Mus musculus] emb|CAM24652.1| olfactory... receptor 1090 [Mus musculus] gb|EDL27371.1| olfactory receptor 1090 [Mus musculus] NP_667058.1 1e-166 93% ...

  1. NCBI nr-aa BLAST: CBRC-STRI-01-1441 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-STRI-01-1441 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 1e-110 78% ...

  2. NCBI nr-aa BLAST: CBRC-EEUR-01-1009 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-1009 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-149 83% ...

  3. NCBI nr-aa BLAST: CBRC-RNOR-10-0097 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-10-0097 ref|NP_667088.1| olfactory receptor 1395 [Mus musculus] gb|AAL60876.1| olfactory... receptor MOR277-1 [Mus musculus] gb|AAP71777.1| olfactory receptor Olfr1395 [Mus musculus] emb|CAM46261.1| olfactory... receptor 1395 [Mus musculus] gb|EDL33774.1| olfactory receptor 1395 [Mus musculus] NP_667088.1 1e-102 61% ...

  4. NCBI nr-aa BLAST: CBRC-SARA-01-0312 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SARA-01-0312 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-137 76% ...

  5. NCBI nr-aa BLAST: CBRC-LAFR-01-2874 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-2874 ref|NP_667230.1| olfactory receptor 1054 [Mus musculus] gb|AAL60732.1| olfactory... receptor MOR188-2 [Mus musculus] gb|AAP71498.1| olfactory receptor Olfr1054 [Mus musculus] emb|CAM17888.1| olfactory... receptor 1054 [Mus musculus] gb|EDL27363.1| olfactory receptor 1054 [Mus musculus] NP_667230.1 3e-83 60% ...

  6. NCBI nr-aa BLAST: CBRC-PCAP-01-0810 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PCAP-01-0810 ref|NP_667230.1| olfactory receptor 1054 [Mus musculus] gb|AAL60732.1| olfactory... receptor MOR188-2 [Mus musculus] gb|AAP71498.1| olfactory receptor Olfr1054 [Mus musculus] emb|CAM17888.1| olfactory... receptor 1054 [Mus musculus] gb|EDL27363.1| olfactory receptor 1054 [Mus musculus] NP_667230.1 1e-101 62% ...

  7. NCBI nr-aa BLAST: CBRC-BTAU-01-0483 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-0483 ref|NP_666854.1| olfactory receptor 1155 [Mus musculus] gb|AAL61117.1| olfactory... receptor MOR174-10 [Mus musculus] gb|AAP71568.1| olfactory receptor Olfr1155 [Mus musculus] emb|CAM18637.1| olfactory... receptor 1155 [Mus musculus] gb|EDL27414.1| olfactory receptor 1155 [Mus musculus] NP_666854.1 1e-125 77% ...

  8. NCBI nr-aa BLAST: CBRC-ETEL-01-0939 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0939 ref|NP_667192.1| olfactory receptor 1260 [Mus musculus] gb|AAL60770.1| olfactory... receptor MOR232-2 [Mus musculus] gb|AAP71654.1| olfactory receptor Olfr1260 [Mus musculus] emb|CAM27664.1| olfactory... receptor 1260 [Mus musculus] gb|EDL27466.1| olfactory receptor 1260 [Mus musculus] NP_667192.1 1e-139 76% ...

  9. NCBI nr-aa BLAST: CBRC-BTAU-01-2011 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-2011 ref|NP_667088.1| olfactory receptor 1395 [Mus musculus] gb|AAL60876.1| olfactory... receptor MOR277-1 [Mus musculus] gb|AAP71777.1| olfactory receptor Olfr1395 [Mus musculus] emb|CAM46261.1| olfactory... receptor 1395 [Mus musculus] gb|EDL33774.1| olfactory receptor 1395 [Mus musculus] NP_667088.1 1e-164 91% ...

  10. NCBI nr-aa BLAST: CBRC-LAFR-01-2611 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-2611 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-140 77% ...

  11. NCBI nr-aa BLAST: CBRC-MMUS-02-0028 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0028 ref|NP_667161.1| olfactory receptor 341 [Mus musculus] gb|AAL60801.1| olfactory... receptor MOR136-2 [Mus musculus] gb|AAP70875.1| olfactory receptor Olfr341 [Mus musculus] emb|CAM20475.1| olfactory... receptor 341 [Mus musculus] gb|EDL08679.1| olfactory receptor 341 [Mus musculus] NP_667161.1 1e-148 84% ...

  12. NCBI nr-aa BLAST: CBRC-LAFR-01-4024 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-4024 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 1e-133 75% ...

  13. NCBI nr-aa BLAST: CBRC-SARA-01-1238 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SARA-01-1238 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-116 72% ...

  14. NCBI nr-aa BLAST: CBRC-MMUR-01-0402 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUR-01-0402 ref|NP_667088.1| olfactory receptor 1395 [Mus musculus] gb|AAL60876.1| olfactory... receptor MOR277-1 [Mus musculus] gb|AAP71777.1| olfactory receptor Olfr1395 [Mus musculus] emb|CAM46261.1| olfactory... receptor 1395 [Mus musculus] gb|EDL33774.1| olfactory receptor 1395 [Mus musculus] NP_667088.1 5e-32 80% ...

  15. NCBI nr-aa BLAST: CBRC-DNOV-01-0483 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-0483 ref|NP_667122.1| olfactory receptor 1377 [Mus musculus] gb|AAL60840.1| olfactory... receptor MOR129-1 [Mus musculus] gb|AAP71759.1| olfactory receptor Olfr1377 [Mus musculus] emb|CAI35307.1| olfactory... receptor 1377 [Mus musculus] gb|EDL33683.1| olfactory receptor 1377 [Mus musculus] NP_667122.1 1e-140 79% ...

  16. NCBI nr-aa BLAST: CBRC-BTAU-01-0513 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-0513 ref|NP_666854.1| olfactory receptor 1155 [Mus musculus] gb|AAL61117.1| olfactory... receptor MOR174-10 [Mus musculus] gb|AAP71568.1| olfactory receptor Olfr1155 [Mus musculus] emb|CAM18637.1| olfactory... receptor 1155 [Mus musculus] gb|EDL27414.1| olfactory receptor 1155 [Mus musculus] NP_666854.1 1e-125 77% ...

  17. NCBI nr-aa BLAST: CBRC-CPOR-01-0795 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CPOR-01-0795 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 4e-74 52% ...

  18. NCBI nr-aa BLAST: CBRC-GGOR-01-1194 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GGOR-01-1194 ref|NP_666646.1| olfactory receptor 993 [Mus musculus] gb|AAL61326.1| olfactory... receptor MOR203-2 [Mus musculus] gb|AAP71451.1| olfactory receptor Olfr993 [Mus musculus] emb|CAM24030.1| olfactory... receptor 993 [Mus musculus] gb|EDL27327.1| olfactory receptor 993 [Mus musculus] NP_666646.1 1e-110 67% ...

  19. NCBI nr-aa BLAST: CBRC-MMUS-02-0150 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0150 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-133 74% ...

  20. NCBI nr-aa BLAST: CBRC-CPOR-01-0039 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CPOR-01-0039 ref|NP_667019.1| olfactory receptor 1240 [Mus musculus] gb|AAL60949.1| olfactory... receptor MOR231-8 [Mus musculus] gb|AAP71635.1| olfactory receptor Olfr1240 [Mus musculus] emb|CAM27922.1| olfactory... receptor 1240 [Mus musculus] gb|EDL27460.1| olfactory receptor 1240 [Mus musculus] NP_667019.1 1e-136 76% ...

  1. NCBI nr-aa BLAST: CBRC-LAFR-01-2829 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-2829 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-137 78% ...

  2. NCBI nr-aa BLAST: CBRC-LAFR-01-3501 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-3501 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-117 67% ...

  3. NCBI nr-aa BLAST: CBRC-LAFR-01-3226 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-3226 ref|NP_666854.1| olfactory receptor 1155 [Mus musculus] gb|AAL61117.1| olfactory... receptor MOR174-10 [Mus musculus] gb|AAP71568.1| olfactory receptor Olfr1155 [Mus musculus] emb|CAM18637.1| olfactory... receptor 1155 [Mus musculus] gb|EDL27414.1| olfactory receptor 1155 [Mus musculus] NP_666854.1 1e-110 77% ...

  4. NCBI nr-aa BLAST: CBRC-STRI-01-1815 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-STRI-01-1815 ref|NP_666644.1| olfactory receptor 994 [Mus musculus] gb|AAL61328.1| olfactory... receptor MOR203-4 [Mus musculus] gb|AAP71452.1| olfactory receptor Olfr994 [Mus musculus] emb|CAM24031.1| olfactory... receptor 994 [Mus musculus] gb|EDL27328.1| olfactory receptor 994 [Mus musculus] NP_666644.1 1e-139 79% ...

  5. NCBI nr-aa BLAST: CBRC-OPRI-01-1221 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OPRI-01-1221 ref|NP_666646.1| olfactory receptor 993 [Mus musculus] gb|AAL61326.1| olfactory... receptor MOR203-2 [Mus musculus] gb|AAP71451.1| olfactory receptor Olfr993 [Mus musculus] emb|CAM24030.1| olfactory... receptor 993 [Mus musculus] gb|EDL27327.1| olfactory receptor 993 [Mus musculus] NP_666646.1 1e-139 77% ...

  6. NCBI nr-aa BLAST: CBRC-STRI-01-2296 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-STRI-01-2296 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-130 74% ...

  7. NCBI nr-aa BLAST: CBRC-EEUR-01-1209 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-1209 ref|NP_667088.1| olfactory receptor 1395 [Mus musculus] gb|AAL60876.1| olfactory... receptor MOR277-1 [Mus musculus] gb|AAP71777.1| olfactory receptor Olfr1395 [Mus musculus] emb|CAM46261.1| olfactory... receptor 1395 [Mus musculus] gb|EDL33774.1| olfactory receptor 1395 [Mus musculus] NP_667088.1 1e-101 58% ...

  8. NCBI nr-aa BLAST: CBRC-LAFR-01-0121 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0121 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-111 81% ...

  9. NCBI nr-aa BLAST: CBRC-MMUR-01-0611 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUR-01-0611 ref|NP_667088.1| olfactory receptor 1395 [Mus musculus] gb|AAL60876.1| olfactory... receptor MOR277-1 [Mus musculus] gb|AAP71777.1| olfactory receptor Olfr1395 [Mus musculus] emb|CAM46261.1| olfactory... receptor 1395 [Mus musculus] gb|EDL33774.1| olfactory receptor 1395 [Mus musculus] NP_667088.1 1e-101 59% ...

  10. NCBI nr-aa BLAST: CBRC-MDOM-05-0203 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MDOM-05-0203 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 1e-148 83% ...

  11. NCBI nr-aa BLAST: CBRC-CFAM-18-0201 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CFAM-18-0201 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-146 81% ...

  12. NCBI nr-aa BLAST: CBRC-LAFR-01-1398 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-1398 ref|NP_667151.1| olfactory receptor 352 [Mus musculus] gb|AAL60811.1| olfactory... receptor MOR136-10 [Mus musculus] gb|AAP70886.1| olfactory receptor Olfr352 [Mus musculus] emb|CAM16518.1| olfactory... receptor 352 [Mus musculus] gb|EDL08690.1| olfactory receptor 352 [Mus musculus] NP_667151.1 1e-133 78% ...

  13. NCBI nr-aa BLAST: CBRC-CPOR-01-1270 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CPOR-01-1270 ref|NP_667058.1| olfactory receptor 1090 [Mus musculus] gb|AAL60909.1| olfactory... receptor MOR188-4 [Mus musculus] gb|AAP71517.1| olfactory receptor Olfr1090 [Mus musculus] emb|CAM24652.1| olfactory... receptor 1090 [Mus musculus] gb|EDL27371.1| olfactory receptor 1090 [Mus musculus] NP_667058.1 1e-106 62% ...

  14. NCBI nr-aa BLAST: CBRC-LAFR-01-3876 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-3876 ref|NP_667077.1| olfactory receptor 1008 [Mus musculus] gb|AAL60887.1| olfactory... receptor MOR187-3 [Mus musculus] gb|AAP71460.1| olfactory receptor Olfr1008 [Mus musculus] emb|CAM16171.1| olfactory... receptor 1008 [Mus musculus] gb|EDL27333.1| olfactory receptor 1008 [Mus musculus] NP_667077.1 5e-60 58% ...

  15. NCBI nr-aa BLAST: CBRC-RNOR-03-0043 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-03-0043 ref|NP_666480.1| olfactory receptor 361 [Mus musculus] gb|AAL61388.1| olfactory... receptor MOR159-3 [Mus musculus] gb|AAP70894.1| olfactory receptor Olfr361 [Mus musculus] emb|CAM20133.1| olfactory... receptor 361 [Mus musculus] gb|EDL08698.1| olfactory receptor 361 [Mus musculus] NP_666480.1 1e-153 85% ...

  16. NCBI nr-aa BLAST: CBRC-CJAC-01-0139 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CJAC-01-0139 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-140 81% ...

  17. NCBI nr-aa BLAST: CBRC-FCAT-01-0901 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FCAT-01-0901 ref|NP_666507.1| olfactory receptor 1276 [Mus musculus] gb|AAL61363.1| olfactory... receptor MOR245-10 [Mus musculus] gb|AAP71670.1| olfactory receptor Olfr1276 [Mus musculus] emb|CAM27563.1| olfactory... receptor 1276 [Mus musculus] gb|EDL27803.1| olfactory receptor 1276 [Mus musculus] NP_666507.1 1e-140 79% ...

  18. NCBI nr-aa BLAST: CBRC-MMUS-02-0339 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0339 ref|NP_666507.1| olfactory receptor 1276 [Mus musculus] gb|AAL61363.1| olfactory... receptor MOR245-10 [Mus musculus] gb|AAP71670.1| olfactory receptor Olfr1276 [Mus musculus] emb|CAM27563.1| olfactory... receptor 1276 [Mus musculus] gb|EDL27803.1| olfactory receptor 1276 [Mus musculus] NP_666507.1 1e-135 76% ...

  19. NCBI nr-aa BLAST: CBRC-RNOR-03-0360 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-03-0360 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 1e-148 84% ...

  20. NCBI nr-aa BLAST: CBRC-MMUS-02-0138 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0138 ref|NP_667223.1| olfactory receptor 1047 [Mus musculus] gb|AAL60739.1| olfactory... receptor MOR188-3 [Mus musculus] gb|AAP71493.1| olfactory receptor Olfr1047 [Mus musculus] emb|CAM18161.1| olfactory... receptor 1047 [Mus musculus] gb|EDL27358.1| olfactory receptor 1047 [Mus musculus] NP_667223.1 1e-136 76% ...

  1. NCBI nr-aa BLAST: CBRC-PCAP-01-0835 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PCAP-01-0835 ref|NP_666644.1| olfactory receptor 994 [Mus musculus] gb|AAL61328.1| olfactory... receptor MOR203-4 [Mus musculus] gb|AAP71452.1| olfactory receptor Olfr994 [Mus musculus] emb|CAM24031.1| olfactory... receptor 994 [Mus musculus] gb|EDL27328.1| olfactory receptor 994 [Mus musculus] NP_666644.1 1e-137 78% ...

  2. NCBI nr-aa BLAST: CBRC-DNOV-01-1645 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-1645 ref|NP_667189.1| olfactory receptor 1258 [Mus musculus] gb|AAL60773.1| olfactory... receptor MOR232-3 [Mus musculus] gb|AAP71652.1| olfactory receptor Olfr1258 [Mus musculus] emb|CAM27661.1| olfactory... receptor 1258 [Mus musculus] gb|EDL27464.1| olfactory receptor 1258 [Mus musculus] NP_667189.1 1e-117 66% ...

  3. NCBI nr-aa BLAST: CBRC-TBEL-01-2547 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TBEL-01-2547 ref|NP_667194.1| olfactory receptor 1256 [Mus musculus] gb|AAL60768.1| olfactory... receptor MOR231-1 [Mus musculus] gb|AAP71649.1| olfactory receptor Olfr1256 [Mus musculus] emb|CAM19163.1| olfactory... receptor 1256 [Mus musculus] gb|EDL27463.1| olfactory receptor 1256 [Mus musculus] NP_667194.1 1e-138 77% ...

  4. Dicty_cDB: Contig-U04544-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available mpling_GS-35-01-01-1... 44 2.1 1 ( CU575212 ) Theobroma cacao, mRNA sequence (KZ0AAP1YH23). 44 2.1 1 ( AC165...rom cultivar ... 42 8.1 1 ( CU608535 ) Theobroma cacao, mRNA sequence (KZ0AAM4YK09FM1). 42 8.1 1 ( FG666317

  5. PcMtr, an aromatic and neutral aliphatic amino acid permease of Penicillium chrysogenum

    OpenAIRE

    Trip, H; EVERS, ME; Driessen, AJM

    2004-01-01

    The gene encoding an aromatic and neutral aliphatic amino acid permease of Penicillium chrysogenum was cloned, functionally expressed and characterized in Saccharomyces cerevisiae M4276. The permease, designated PcMtr, is structurally and functionally homologous to Mtr of Neurospora crassa, and unrelated to the Amino Acid Permease (AAP) family which includes most amino acid permeases in fungi. Database searches of completed fungal genome sequences reveal that Mtr type permeases are not widely...

  6. EST Table: CN376273 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CN376273 rzhswab0_002215 10/09/28 42 %/131 aa ref|YP_145791.1| polyprotein [Varroa ...destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/09/01 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 L12 ...

  7. EST Table: CK529907 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK529907 rswfa0_000778.y1 10/09/29 58 %/131 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swf ...

  8. EST Table: CK523603 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK523603 rswea0_009713.y1 10/09/29 47 %/185 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h DN237490 swe ...

  9. EST Table: CK510758 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK510758 rswdd0_006586.y1 10/09/29 52 %/216 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/30 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swd ...

  10. EST Table: DN237490 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available 019079(viral genome replication) 10/09/29 44 %/102 aa ref|YP_145791.1| polyprotein [Varroa destructor virus ...1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/09/03 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h DN237490 BmP ...

  11. EST Table: CK528102 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK528102 rswfa0_005915.y1 10/09/29 40 %/123 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swf ...

  12. EST Table: CK541979 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK541979 rswhb0_006233.y1 10/09/29 48 %/164 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swh ...

  13. EST Table: CK489452 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK489452 rswab0_007236.y1 10/09/29 42 %/134 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/30 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swa ...

  14. EST Table: CK528690 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK528690 rswfa0_007768.y1 11/12/09 10/09/29 51 %/217 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swf ...

  15. EST Table: CK518734 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK518734 rswea0_001019.y1 10/09/29 39 %/171 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h DN237490 swe ...

  16. EST Table: CK501708 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK501708 rswcc0_001346.y1 10/09/29 45 %/174 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/30 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h DN237490 swc ...

  17. EST Table: CK544693 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK544693 rswhb0_014928.y1 10/09/29 53 %/193 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swh ...

  18. EST Table: CK520549 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK520549 rswea0_004258.y1 10/09/29 45 %/102 aa ref|YP_145791.1| polyprotein [Varroa... destructor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/08/31 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h CK528690 swe ...

  19. EST Table: DN237513 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available DN237513 EST00639 10/09/29 45 %/111 aa ref|YP_145791.1| polyprotein [Varroa destruc...tor virus 1] gb|AAP51418.2| polyprotein [Varroa destructor virus 1] 10/09/03 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h DN237490 BmP ...

  20. Characterization and biological effects of two polysaccharides isolated from Acanthopanax sciadophylloides.

    Science.gov (United States)

    Lee, Jung-Bum; Tanikawa, Tatsuya; Hayashi, Kyoko; Asagi, Mariko; Kasahara, Yoshimasa; Hayashi, Toshimitsu

    2015-02-13

    Two polysaccharides abbreviated ANP and AAP were isolated from the young buds of Acanthopanax sciadophylloides. ANP consisted of L-arabinose, D-mannose, D-glucose and D-galactose in a ratio of ca 1.0:2.6:2.5:1.4 and its weight average molecular weight (Mw) was 1.07×10(4). AAP consisted of L-arabinose, D-galactose and 4-O-methyl-D-glucuronic acid in a ratio of ca 5:10:1, and its Mw was estimated to be 8.40×10(4). ANP was suggested to be an acetylated heteropolysaccharide, whereas AAP was speculated to be a type II arabinogalactan on the basis of structural analysis data. Both polysaccharides were found to stimulate NO production and induce the expression of cytokine mRNAs including IL-1β, IL-6, IL-10 and TNF-α on RAW264.7 cells. They also induced NF-κB activation in RAW-Blue cells. NO production and NF-κB activation by both polysaccharides were decreased by pretreatment with neutralizing anti-TLR-4 and anti-CD14 antibodies but not with anti-TLR-2, anti-SR-A, anti-CD11c, and anti-Dectin-1 antibodies. Therefore, these immunostimulating effects of ANP and AAP were suggested to be promoted by the interaction through the membrane receptors, TLR-4 and CD14. In addition to immunomodulating effects, ANP showed anti-HSV-2 effects in vitro.

  1. Enzyme histochemical studies of membrane proteases in rat subfornical organ.

    Science.gov (United States)

    De Bault, L E; Mitro, A

    1994-12-01

    Localization of membrane proteases glutamyl aminopeptidase (EAP), microsomal alanyl aminopeptidase (mAAP), dipeptidyl peptidase IV (DPP IV) and gamma-glutamyl transpeptidase (gamma-GTP) were studied in vessels of the rat subfornical organ (SFO), ependyma which cover the surface of the SFO, and adjacent brain structures. Results of enzyme histochemical reactions showed strong activity for EAP, mAAP, and gamma-GTP, but absence of DPP IV in microvessels of SFO. The ependyma which cover the SFO was positive for gamma-GTP, but negative for other studied proteases. Our results showed that the spectrum of enzymes in the majority of the vessels of SFO is similar to that of the microvessels of the adjacent brain tissue which were positive for EAP, mAAP, and gamma-GTP, but negative for DPP IV. The relative intensity of the enzyme reactions in vessels varied from central to lateral locations in the SFO and the adjacent brain tissue. There was also a difference in the relative reaction intensity from one enzyme to the other. The presence and heterogeneous distribution of the enzymes are consistent with the hypothesis that membrane proteases of the microvascular endothelium constitute an enzyme-barrier between blood and parenchyma of the SFO and between blood and brain tissue, and may be involved in metabolism or modulation of various peptides when they contact the plasma membrane of the endothelial cells of the vessels.

  2. Novel parvoviruses in reptiles and genome sequence of a lizard parvovirus shed light on Dependoparvovirus genus evolution.

    Science.gov (United States)

    Pénzes, Judit J; Pham, Hanh T; Benkö, Mária; Tijssen, Peter

    2015-09-01

    Here, we report the detection and partial genome characterization of two novel reptilian parvoviruses derived from a short-tailed pygmy chameleon (Rampholeon brevicaudatus) and a corn snake (Pantherophis guttatus) along with the complete genome analysis of the first lizard parvovirus, obtained from four bearded dragons (Pogona vitticeps). Both homology searches and phylogenetic tree reconstructions demonstrated that all are members of the genus Dependoparvovirus. Even though most dependoparvoviruses replicate efficiently only in co-infections with large DNA viruses, no such agents could be detected in one of the bearded dragon samples, hence the possibility of autonomous replication was explored. The alternative ORF encoding the full assembly activating protein (AAP), typical for the genus, could be obtained from reptilian parvoviruses for the first time, with a structure that appears to be more ancient than that of avian and mammalian parvoviruses. All three viruses were found to harbour short introns as previously observed for snake adeno-associated virus, shorter than that of any non-reptilian dependoparvovirus. According to the phylogenetic calculations based on full non-structural protein (Rep) and AAP sequences, the monophyletic cluster of reptilian parvoviruses seems to be the most basal out of all lineages of genus Dependoparvovirus. The suspected ability for autonomous replication, results of phylogenetic tree reconstruction, intron lengths and the structure of the AAP suggested that a single Squamata origin instead of the earlier assumed diapsid (common avian-reptilian) origin is more likely for the genus Dependoparvovirus of the family Parvoviridae.

  3. Male circumcision for the prevention of acquisition and transmission of sexually transmitted infections: the case for neonatal circumcision.

    Science.gov (United States)

    Tobian, Aaron A R; Gray, Ronald H; Quinn, Thomas C

    2010-01-01

    The American Academy of Pediatrics (AAP) male circumcision policy states that while there are potential medical benefits of newborn male circumcision, the data are insufficient to recommend routine neonatal circumcision. Since 2005, however, 3 randomized trials have evaluated male circumcision for prevention of sexually transmitted infections. The trials found that circumcision decreases human immunodeficiency virus acquisition by 53% to 60%, herpes simplex virus type 2 acquisition by 28% to 34%, and human papillomavirus prevalence by 32% to 35% in men. Among female partners of circumcised men, bacterial vaginosis was reduced by 40%, and Trichomonas vaginalis infection was reduced by 48%. Genital ulcer disease was also reduced among males and their female partners. These findings are also supported by observational studies conducted in the United States. The AAP policy has a major impact on neonatal circumcision in the United States. This review evaluates the recent data that support revision of the AAP policy to fully reflect the evidence of long-term health benefits of male circumcision.

  4. Scope of practice issues in the delivery of pediatric health care.

    Science.gov (United States)

    2013-06-01

    The American Academy of Pediatrics (AAP) believes that optimal pediatric health care depends on a team-based approach with supervision by a physician leader, preferably a pediatrician. The pediatrician, here defined to include not only pediatric generalists but all pediatric medical subspecialists, all surgical specialists, and internal medicine/pediatric physicians, is uniquely qualified to manage, coordinate, and supervise the entire spectrum of pediatric care, from diagnosis through all stages of treatment, in all practice settings. The AAP recognizes the valuable contributions of nonphysician clinicians, including nurse practitioners and physician assistants, in delivering optimal pediatric care. However, the expansion of the scope of practice of nonphysician pediatric clinicians raises critical public policy and child health advocacy concerns. Pediatricians should serve as advocates for optimal pediatric care in state legislatures, public policy forums, and the media and should pursue opportunities to resolve scope of practice conflicts outside state legislatures. The AAP affirms the importance of appropriate documentation and standards in pediatric education, training, skills, clinical competencies, examination, regulation, and patient care to ensure safety and quality health care for all infants, children, adolescents, and young adults.

  5. Media use by children younger than 2 years.

    Science.gov (United States)

    Brown, Ari

    2011-11-01

    In 1999, the American Academy of Pediatrics (AAP) issued a policy statement addressing media use in children. The purpose of that statement was to educate parents about the effects that media--both the amount and the content--may have on children. In one part of that statement, the AAP recommended that "pediatricians should urge parents to avoid television viewing for children under the age of two years." The wording of the policy specifically discouraged media use in this age group, although it is frequently misquoted by media outlets as no media exposure in this age group. The AAP believed that there were significantly more potential negative effects of media than positive ones for this age group and, thus, advised families to thoughtfully consider media use for infants. This policy statement reaffirms the 1999 statement with respect to media use in infants and children younger than 2 years and provides updated research findings to support it. This statement addresses (1) the lack of evidence supporting educational or developmental benefits for media use by children younger than 2 years, (2) the potential adverse health and developmental effects of media use by children younger than 2 years, and (3) adverse effects of parental media use (background media) on children younger than 2 years.

  6. Skylab Illustration

    Science.gov (United States)

    1972-01-01

    This artist's concept is a cutaway illustration of the Skylab with the Command/Service Module being docked to the Multiple Docking Adapter. In an early effort to extend the use of Apollo for further applications, NASA established the Apollo Applications Program (AAP) in August of 1965. The AAP was to include long duration Earth orbital missions during which astronauts would carry out scientific, technological, and engineering experiments in space by utilizing modified Saturn launch vehicles and the Apollo spacecraft. Established in 1970, the Skylab Program was the forerurner of the AAP. The goals of the Skylab were to enrich our scientific knowledge of the Earth, the Sun, the stars, and cosmic space; to study the effects of weightlessness on living organisms, including man; to study the effects of the processing and manufacturing of materials utilizing the absence of gravity; and to conduct Earth resource observations. The Skylab also conducted 19 selected experiments submitted by high school students. Skylab's 3 different 3-man crews spent up to 84 days in Earth orbit. The Marshall Space Flight Center (MSFC) had responsibility for developing and integrating most of the major components of the Skylab: the Orbital Workshop (OWS), Airlock Module (AM), Multiple Docking Adapter (MDA), Apollo Telescope Mount (ATM), Payload Shroud (PS), and most of the experiments. MSFC was also responsible for providing the Saturn IB launch vehicles for three Apollo spacecraft and crews and a Saturn V launch vehicle for the Skylab.

  7. Skylab Program Illustration

    Science.gov (United States)

    1971-01-01

    This image illustrates major areas of emphasis of the Skylab Program. In an early effort to extend the use of Apollo for further applications, NASA established the Apollo Applications Program (AAP) in August of 1965. The AAP was to include long duration Earth orbital missions during which astronauts would carry out scientific, technological, and engineering experiments in space by utilizing modified Saturn launch vehicles and the Apollo spacecraft. Established in 1970, the Skylab Program was the forerurner of the AAP. The goals of the Skylab were to enrich our scientific knowledge of the Earth, the Sun, the stars, and cosmic space; to study the effects of weightlessness on living organisms, including man; to study the effects of the processing and manufacturing of materials utilizing the absence of gravity; and to conduct Earth resource observations. The Skylab also conducted 19 selected experiments submitted by high school students. Skylab's 3 different 3-man crews spent up to 84 days in Earth orbit. The Marshall Space Flight Center (MSFC) had responsibility for developing and integrating most of the major components of the Skylab: the Orbital Workshop (OWS), Airlock Module (AM), Multiple Docking Adapter (MDA), Apollo Telescope Mount (ATM), Payload Shroud (PS), and most of the experiments. MSFC was also responsible for providing the Saturn IB launch vehicles for three Apollo spacecraft and crews and a Saturn V launch vehicle for the Skylab.

  8. Overexpression of ubiquitin and amino acid permease genes in association with antimony resistance in Leishmania tropica field isolates.

    Science.gov (United States)

    Kazemi-Rad, Elham; Mohebali, Mehdi; Khadem-Erfan, Mohammad Bagher; Hajjaran, Homa; Hadighi, Ramtin; Khamesipour, Ali; Rezaie, Sassan; Saffari, Mojtaba; Raoofian, Reza; Heidari, Mansour

    2013-08-01

    The mainstay therapy against leishmaniasis is still pentavalent antimonial drugs; however, the rate of antimony resistance is increasing in endemic regions such as Iran. Understanding the molecular basis of resistance to antimonials could be helpful to improve treatment strategies. This study aimed to recognize genes involved in antimony resistance of Leishmania tropica field isolates. Sensitive and resistant L. tropica parasites were isolated from anthroponotic cutaneous leishmaniasis patients and drug susceptibility of parasites to meglumine antimoniate (Glucantime®) was confirmed using in vitro assay. Then, complementary DNA-amplified fragment length polymorphism (cDNA-AFLP) and real-time reverse transcriptase-PCR (RT-PCR) approaches were utilized on mRNAs from resistant and sensitive L. tropica isolates. We identified 2 known genes, ubiquitin implicated in protein degradation and amino acid permease (AAP3) involved in arginine uptake. Also, we identified 1 gene encoding hypothetical protein. Real-time RT-PCR revealed a significant upregulation of ubiquitin (2.54-fold), and AAP3 (2.86-fold) (P<0.05) in a resistant isolate compared to a sensitive one. Our results suggest that overexpression of ubiquitin and AAP3 could potentially implicated in natural antimony resistance.

  9. Binding of aromatic amines to the rat hepatic Ah receptor in vitro and in vivo and the 8S and 4S estrogen receptor of rat uterus and rat liver

    Energy Technology Data Exchange (ETDEWEB)

    Cikryt, P.; Kaiser, T.; Gottlicher, M. (Univ. of Wuerzburg (West Germany))

    1990-08-01

    Studies on structurally related aromatic amines with different carcinogenic properties have shown that 2-acetylaminofluorene (2-AAF) and 2-acetylaminophenanthrene (AAP) inhibit the binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the Ah receptor in vitro. The apparent inhibitor constants (K{sub i}) are 2.3 {mu}M for 2-AAF and 2.7 {mu}M for AAP. In contrast, 4-acetylaminofluorene, an isomer of 2-AAF, and trans-4-acetylaminostilbene do not bind to the rat hepatic cytosolic Ah receptor. Pretreating female Wistar rats with 2-AAF or AAP leads to the induction of the P-450 isoenzymes that are under the control of the Ah receptor. Ornithine decarboxylase activity is induced by all aromatic amines tested irrespective of their Ah receptor affinity. The aromatic amines used as model compounds do not inhibit the binding of 17-{beta}-estradiol to the 8S and 4S estrogen receptor of rat uterus or rat liver in a competition assay analyzed using sucrose density gradient centrifugation. On the other hand, the aromatic amines bind to varying extents to another estrogen-binding protein of rat liver whose function and identity is still unknown. The study demonstrates that structurally related aromatic amines in their unmetabolized form interact differentially with a cellular target protein, the Ah receptor, in vitro as well as in vivo. However, a relationship between these effects and the postulated promoting properties of 2-AAF remains to be established.

  10. Lupeol protects against acetaminophen-induced oxidative stress and cell death in rat primary hepatocytes.

    Science.gov (United States)

    Kumari, Archana; Kakkar, Poonam

    2012-05-01

    Drug induced hepatotoxicity is a major problem where phytochemicals hold promise for its abrogation. This study was carried out to explore cytoprotective potential of lupeol, a triterpene, against acetaminophen (AAP)-induced toxicity in rat hepatocytes. AAP exposure significantly (p<0.05) reduced cell viability, disturbed Bcl-2 family pro/anti-apoptotic protein balance, increased ROS production and altered redox homeostasis. It also induced mitochondria-mediated hepatocellular injury by significant mitochondrial depolarization, caspase-9/3 activation and subsequent DNA fragmentation. Our results suggest that lupeol pre-treatment effectively restored antioxidant enzyme levels, decreased lipid peroxidation, inhibited ROS generation and depolarization of mitochondria. Lupeol also attenuated mitochondria-mediated signaling pathway and DNA damage as evident from TUNEL assay and cell cycle studies leading to prevention of cytotoxicity. This study confirms the efficacy of lupeol, a food derived antioxidant, in abrogating ROS generation, maintaining redox balance and providing significant protection against mitochondria-mediated cell death during AAP-induced toxicity.

  11. Proximate and elemental analysis of infant formula.

    Science.gov (United States)

    Tanner, J T

    1982-11-01

    The Nutrient Surveillance Branch has been conducting a survey of infant formula products for Fiscal Year 1981. Each product has been carefully analyzed and the results compared to the label declaration and the minimum-maximum limits specified by the American Academy of Pediatrics' Committee on Nutrition (CON/AAP). Proximate and elemental analyses were made. Protein, fat, ash, and total solids (moisture) were determined by AOAC methods. Osmolality, density, and fatty acids (linoleic) were also determined. Carbohydrates were calculated by difference and caloric content was calculated by using the general Atwater factors. Elemental analysis for Ca, P, Mg, Fe, Zn, Cu, Mn, Na, and K were performed by induction coupled plasma absorption spectroscopy. Chloride was assayed by potentiometric titration with AgNO3. A summary of the findings from the infant formula survey have been compared with CON/AAP recommendations. In general, there were only a few exceptions where the label claims and the CON/AAP requirements were not met. However, in none of these cases was the difference considered to be of public health significance.

  12. Elevated expression of mechanosensory polycystins in human carotid atherosclerotic plaques: association with p53 activation and disease severity.

    Science.gov (United States)

    Varela, Aimilia; Piperi, Christina; Sigala, Fragiska; Agrogiannis, George; Davos, Constantinos H; Andri, Maria-Anastasia; Manopoulos, Christos; Tsangaris, Sokrates; Basdra, Efthimia K; Papavassiliou, Athanasios G

    2015-08-19

    Atherosclerotic plaque formation is associated with irregular distribution of wall shear stress (WSS) that modulates endothelial function and integrity. Polycystins (PC)-1/-2 constitute a flow-sensing protein complex in endothelial cells, able to respond to WSS and induce cell-proliferation changes leading to atherosclerosis. An endothelial cell-culture system of measurable WSS was established to detect alterations in PCs expression under conditions of low- and high-oscillatory shear stress in vitro. PCs expression and p53 activation as a regulator of cell proliferation were further evaluated in vivo and in 69 advanced human carotid atherosclerotic plaques (AAPs). Increased PC-1/PC-2 expression was observed at 30-60 min of low shear stress (LSS) in endothelial cells. Elevated PC-1 expression at LSS was followed by p53 potentiation. PCs immunoreactivity localizes in areas with macrophage infiltration and neovascularization. PC-1 mRNA and protein levels were significantly higher than PC-2 in stable fibroatherotic (V) and unstable/complicated (VI) AAPs. Elevated PC-1 immunostaining was detected in AAPs from patients with diabetes mellitus, dyslipidemia, hypertension and carotid stenosis, at both arteries (50%) or in one artery (90%). PCs seem to participate in plaque formation and progression. Since PC-1 upregulation coincides with p38 and p53 activation, a potential interplay of these molecules in atherosclerosis induction is posed.

  13. Compliance of Parenting Magazines Advertisements with American Academy of Pediatrics Recommendations.

    Science.gov (United States)

    Pitt, Michael B; Berger, Jennifer N; Sheehan, Karen M

    2016-11-01

    This study examined 3218 advertisements from the two parenting magazines with highest circulation in the United States. The authors compared each advertisement for a product for use by children, against all the published recommendations of the American Academy of Pediatrics (AAP) on topics such as toy safety, helmet use, age-defined choking hazards, infant sleep safety, and others. Any advertisement with images or products which went against a published AAP recommendation was deemed as non-adherence and was categorized according to the statement it contradicted. Nearly one in six (15.7%) of the advertisements contained example(s) of non-adherence to AAP recommendations, with twelve categories of offense represented. Categories ranked by overall share from most to least include: non-Food and Drug Administration (FDA) approved medical treatments, age-defined choking hazards, vitamins, cold medicine, formula, oral care, screen time, toy/playground safety, infant sleep, nutrition, water safety, and fall risk. Given that repeated exposure to messages in advertisements has been associated with changes in health decision-making, and parents often turn to parenting magazines for advice and ideas regarding their children, the publishers might consider screening the content in order to prevent confusing and potentially dangerous messages from being disseminated in the media.

  14. SIDS and other sleep-related infant deaths: expansion of recommendations for a safe infant sleeping environment.

    Science.gov (United States)

    Moon, Rachel Y

    2011-11-01

    Despite a major decrease in the incidence of sudden infant death syndrome (SIDS) since the American Academy of Pediatrics (AAP) released its recommendation in 1992 that infants be placed for sleep in a nonprone position, this decline has plateaued in recent years. Concurrently, other causes of sudden unexpected infant death that occur during sleep (sleep-related deaths), including suffocation, asphyxia, and entrapment, and ill-defined or unspecified causes of death have increased in incidence, particularly since the AAP published its last statement on SIDS in 2005. It has become increasingly important to address these other causes of sleep-related infant death. Many of the modifiable and nonmodifiable risk factors for SIDS and suffocation are strikingly similar. The AAP, therefore, is expanding its recommendations from focusing only on SIDS to focusing on a safe sleep environment that can reduce the risk of all sleep-related infant deaths, including SIDS. The recommendations described in this policy statement include supine positioning, use of a firm sleep surface, breastfeeding, room-sharing without bed-sharing, routine immunizations, consideration of using a pacifier, and avoidance of soft bedding, overheating, and exposure to tobacco smoke, alcohol, and illicit drugs. The rationale for these recommendations is discussed in detail in the accompanying "Technical Report--SIDS and Other Sleep-Related Infant Deaths: Expansion of Recommendations for a Safe Infant Sleeping Environment," which is included in this issue of Pediatrics (www.pediatrics.org/cgi/content/full/128/5/e1341).

  15. Synthesis, characterization, antimicrobial screening and computational studies of 4-[3-(4-methoxy-phenyl)-allylideneamino]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one

    Science.gov (United States)

    Obasi, L. N.; Kaior, G. U.; Rhyman, L.; Alswaidan, Ibrahim A.; Fun, Hoong-Kun; Ramasami, P.

    2016-09-01

    The Schiff base, 4-[3-(4-methoxy-phenyl)-allylideneamino]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one (TPMC/AAP) was synthesized by the condensation of 4-aminoantipyrine (4-amino-1,5-dimethyl-2-phenylpyrazole-3-one) and trans-para-methoxycinnamaldehyde (trans-3,4-methoxyphenyl-2-propenal) in dry methanol at 75 °C. The compound was characterized using elemental microanalysis, IR, NMR, UV spectroscopies and single-crystal X-ray crystallography. The X-ray structure determination shows that the Schiff base, (TPMC/AAP) is orthorhombic with the Pbca space group. The anti-microbial screening of the compound was carried out with Escherichia coli, Bacillus subtillis, Staphylococcus aureus, Pseudemonas aeruginosa, Candida albicans and Aspergillus niger using agar well diffusion method. The Schiff base possesses significant antimicrobial activity. The minimum inhibitory concentration (MIC) of the compound was also determined and the activity was compared with that of conventional drugs ciprofloxacin and ketoconazole. The compound (TPMC/AAP) showed varying activity against the cultured bacteria and fungi used. To complement the experimental data, density functional theory (DFT) was used to have deeper understanding into the molecular parameters and infrared spectra of the compound.

  16. Precipitation estimation in mountainous terrain using multivariate geostatistics. Part I: structural analysis

    Science.gov (United States)

    Hevesi, Joseph A.; Istok, Jonathan D.; Flint, Alan L.

    1992-01-01

    Values of average annual precipitation (AAP) are desired for hydrologic studies within a watershed containing Yucca Mountain, Nevada, a potential site for a high-level nuclear-waste repository. Reliable values of AAP are not yet available for most areas within this watershed because of a sparsity of precipitation measurements and the need to obtain measurements over a sufficient length of time. To estimate AAP over the entire watershed, historical precipitation data and station elevations were obtained from a network of 62 stations in southern Nevada and southeastern California. Multivariate geostatistics (cokriging) was selected as an estimation method because of a significant (p = 0.05) correlation of r = .75 between the natural log of AAP and station elevation. A sample direct variogram for the transformed variable, TAAP = ln [(AAP) 1000], was fitted with an isotropic, spherical model defined by a small nugget value of 5000, a range of 190 000 ft, and a sill value equal to the sample variance of 163 151. Elevations for 1531 additional locations were obtained from topographic maps to improve the accuracy of cokriged estimates. A sample direct variogram for elevation was fitted with an isotropic model consisting of a nugget value of 5500 and three nested transition structures: a Gaussian structure with a range of 61 000 ft, a spherical structure with a range of 70 000 ft, and a quasi-stationary, linear structure. The use of an isotropic, stationary model for elevation was considered valid within a sliding-neighborhood radius of 120 000 ft. The problem of fitting a positive-definite, nonlinear model of coregionalization to an inconsistent sample cross variogram for TAAP and elevation was solved by a modified use of the Cauchy-Schwarz inequality. A selected cross-variogram model consisted of two nested structures: a Gaussian structure with a range of 61 000 ft and a spherical structure with a range of 190 000 ft. Cross validation was used for model selection and for

  17. Korean Medication Algorithm for Bipolar Disorder 2014: comparisons with other treatment guidelines

    Directory of Open Access Journals (Sweden)

    Jeong JH

    2015-06-01

    Full Text Available Jong-Hyun Jeong,1 Jeong Goo Lee,2,3 Moon-Doo Kim,4 Inki Sohn,5 Se-Hoon Shim,6 Hee Ryung Wang,1 Young Sup Woo,1 Duk-In Jon,7 Jeong Seok Seo,8 Young-Chul Shin,9 Kyung Joon Min,10 Bo-Hyun Yoon,11 Won-Myong Bahk1 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, 2Department of Psychiatry, Haeundae Paik Hospital, College of Medicine, Paik Institute for Clinical Research, Inje University, 3Department of Health Science and Technology, Graduate School of Inje University, Busan, 4Department of Psychiatry, Jeju National University Hospital, Jeju, 5Department of Psychiatry, Keyo Hospital, Keyo Medical Foundation, Uiwang, 6Department of Psychiatry, Soonchunhyang University Cheonan Hospital, College of Medicine, Soonchunhyang University, Cheonan, 7Department of Psychiatry, Sacred Heart Hospital, College of Medicine, Hallym University, Anyang, 8Department of Psychiatry, Konkuk University Chungju Hospital, School of Medicine, Konkuk University, Chungju, 9Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, 10Department of Psychiatry, Chung-Ang University Hospital, College of Medicine, Chung-Ang University, Seoul, 11Department of Psychiatry, Naju National Hospital, Naju, Korea Abstract: Our goal was to compare the recommendations of the Korean Medication Algorithm Project for Bipolar Disorder 2014 (KMAP-BP 2014 with other recently published guidelines for the treatment of bipolar disorder. We reviewed a total of four recently published global treatment guidelines and compared each treatment recommendation of the KMAP-BP 2014 with those in other guidelines. For the initial treatment of mania, there were no significant differences across treatment guidelines. All recommended mood stabilizer (MS or atypical antipsychotic (AAP monotherapy or the combination of an MS with an AAP as a first-line treatment strategy for mania. However, the KMAP-BP 2014 did not prefer monotherapy

  18. Promoting the well-being of children whose parents are gay or lesbian.

    Science.gov (United States)

    2013-04-01

    To promote optimal health and well-being of all children, the American Academy of Pediatrics (AAP) supports access for all children to (1) civil marriage rights for their parents and (2) willing and capable foster and adoptive parents, regardless of the parents' sexual orientation. The AAP has always been an advocate for, and has developed policies to support, the optimal physical, mental, and social health and well-being of all infants, children, adolescents, and young adults. In so doing, the AAP has supported families in all their diversity, because the family has always been the basic social unit in which children develop the supporting and nurturing relationships with adults that they need to thrive. Children may be born to, adopted by, or cared for temporarily by married couples, nonmarried couples, single parents, grandparents, or legal guardians, and any of these may be heterosexual, gay or lesbian, or of another orientation. Children need secure and enduring relationships with committed and nurturing adults to enhance their life experiences for optimal social-emotional and cognitive development. Scientific evidence affirms that children have similar developmental and emotional needs and receive similar parenting whether they are raised by parents of the same or different genders. If a child has 2 living and capable parents who choose to create a permanent bond by way of civil marriage, it is in the best interests of their child(ren) that legal and social institutions allow and support them to do so, irrespective of their sexual orientation. If 2 parents are not available to the child, adoption or foster parenting remain acceptable options to provide a loving home for a child and should be available without regard to the sexual orientation of the parent(s).

  19. Neonatal circumcision: new recommendations & implications for practice.

    Science.gov (United States)

    Simpson, Elizabeth; Carstensen, Jean; Murphy, Patrick

    2014-01-01

    Neonatal male circumcision is the most common surgical procedure performed on pediatric patients. While the rate of neonatal circumcision in the United States has been dropping, circumcision continues to be frequent, ranging from 42% to 80% among various populations. While the cultural debate over circumcision continues, recent evidence of medical benefits led to a revision of the American Academy of Pediatrics (AAP) circumcision policy statement. In contrast to the 1999 AAP policy statement, the 2012 policy asserts that the preventive benefits of neonatal circumcision outweigh the risk of the procedure, which is well tolerated when performed by trained professionals, under sterile conditions, and with appropriate pain management. This Circumcision Policy Statement has also been endorsed by the American College of Obstetricians and Gynecologists and a similar policy statement is in place from the American Urologic Association. Despite the new recognized health benefits found by the 2012 Task Force of Circumcision (TFOC), circumcision remains controversial even among medical professionals. Other well recognized medical organizations including The American Academy of Family Practice and some international pediatric societies have not adopted such a strong endorsement of circumcision. The policy statements from these organizations continue to more closely resemble the 1999 AAP policy statement that stated, "Existing scientific evidence demonstrates potential medical benefits of newborn male circumcision; however, these data are not sufficient to recommend routine neonatal circumcision." In this review we will summarize historical, cultural and ethical factors in neonatal circumcision and briefly compare common surgical techniques including anesthesia. In addition, we will discuss recent information regarding the benefits and risks of neonatal circumcision. Finally, we will discuss the financial reimbursement of practitioners and the benefits of standardized

  20. Recent and Past Musical Activity Predicts Cognitive Aging Variability: Direct Comparison with Leisure Activities

    Directory of Open Access Journals (Sweden)

    Brenda eHanna-Pladdy

    2012-07-01

    Full Text Available Studies evaluating the impact of modifiable lifestyle factors on cognition offer potential insights into sources of cognitive aging variability. Recently, we reported an association between extent of musical instrumental practice throughout the life span (greater than 10 years on preserved cognitive functioning in advanced age . These findings raise the question of whether there are training-induced brain changes in musicians that can transfer to nonmusical cognitive abilities to allow for compensation of age-related cognitive declines. However, because of the relationship between engagement in lifestyle activities and preserved cognition, it remains unclear whether these findings are specifically driven by musical training or the types of individuals likely to engage in greater activities in general. The current study examined the type of leisure activity (musical versus other as well as the timing of engagement (age of acquisition, past versus recent in predictive models of successful cognitive aging. Seventy age and education matched older musicians (> 10 years and nonmusicians (ages 59-80 were evaluated on neuropsychological tests and life-style activities (AAP. Partition analyses were conducted on significant cognitive measures to explain performance variance in musicians. Musicians scored higher on tests of phonemic fluency, verbal immediate recall, judgment of line orientation (JLO, and Letter Number Sequencing (LNS, but not the AAP. The first partition analysis revealed education best predicted JLO in musicians, followed by recent musical engagement which offset low education. In the second partition analysis, early age of musical acquisition (< 9 years predicted enhanced LNS in musicians, while analyses for AAP, verbal recall and fluency were not predictive. Recent and past musical activity, but not leisure activity, predicted variability across verbal and visuospatial domains in aging. Early musical acquisition predicted auditory

  1. Influence of aripiprazole, risperidone, and amisulpride on sensory and sensorimotor gating in healthy 'low and high gating' humans and relation to psychometry.

    Science.gov (United States)

    Csomor, Philipp A; Preller, Katrin H; Geyer, Mark A; Studerus, Erich; Huber, Theodor; Vollenweider, Franz X

    2014-09-01

    Despite advances in the treatment of schizophrenia spectrum disorders with atypical antipsychotics (AAPs), there is still need for compounds with improved efficacy/side-effect ratios. Evidence from challenge studies suggests that the assessment of gating functions in humans and rodents with naturally low-gating levels might be a useful model to screen for novel compounds with antipsychotic properties. To further evaluate and extend this translational approach, three AAPs were examined. Compounds without antipsychotic properties served as negative control treatments. In a placebo-controlled, within-subject design, healthy males received either single doses of aripiprazole and risperidone (n=28), amisulpride and lorazepam (n=30), or modafinil and valproate (n=30), and placebo. Prepulse inhibiton (PPI) and P50 suppression were assessed. Clinically associated symptoms were evaluated using the SCL-90-R. Aripiprazole, risperidone, and amisulpride increased P50 suppression in low P50 gaters. Lorazepam, modafinil, and valproate did not influence P50 suppression in low gaters. Furthermore, low P50 gaters scored significantly higher on the SCL-90-R than high P50 gaters. Aripiprazole increased PPI in low PPI gaters, whereas modafinil and lorazepam attenuated PPI in both groups. Risperidone, amisulpride, and valproate did not influence PPI. P50 suppression in low gaters appears to be an antipsychotic-sensitive neurophysiologic marker. This conclusion is supported by the association of low P50 suppression and higher clinically associated scores. Furthermore, PPI might be sensitive for atypical mechanisms of antipsychotic medication. The translational model investigating differential effects of AAPs on gating in healthy subjects with naturally low gating can be beneficial for phase II/III development plans by providing additional information for critical decision making.

  2. The diagnosis and management of acute otitis media.

    Science.gov (United States)

    Lieberthal, Allan S; Carroll, Aaron E; Chonmaitree, Tasnee; Ganiats, Theodore G; Hoberman, Alejandro; Jackson, Mary Anne; Joffe, Mark D; Miller, Donald T; Rosenfeld, Richard M; Sevilla, Xavier D; Schwartz, Richard H; Thomas, Pauline A; Tunkel, David E

    2013-03-01

    This evidence-based clinical practice guideline is a revision of the 2004 acute otitis media (AOM) guideline from the American Academy of Pediatrics (AAP) and American Academy of Family Physicians. It provides recommendations to primary care clinicians for the management of children from 6 months through 12 years of age with uncomplicated AOM. In 2009, the AAP convened a committee composed of primary care physicians and experts in the fields of pediatrics, family practice, otolaryngology, epidemiology, infectious disease, emergency medicine, and guideline methodology. The subcommittee partnered with the Agency for Healthcare Research and Quality and the Southern California Evidence-Based Practice Center to develop a comprehensive review of the new literature related to AOM since the initial evidence report of 2000. The resulting evidence report and other sources of data were used to formulate the practice guideline recommendations. The focus of this practice guideline is the appropriate diagnosis and initial treatment of a child presenting with AOM. The guideline provides a specific, stringent definition of AOM. It addresses pain management, initial observation versus antibiotic treatment, appropriate choices of antibiotic agents, and preventive measures. It also addresses recurrent AOM, which was not included in the 2004 guideline. Decisions were made on the basis of a systematic grading of the quality of evidence and benefit-harm relationships. The practice guideline underwent comprehensive peer review before formal approval by the AAP. This clinical practice guideline is not intended as a sole source of guidance in the management of children with AOM. Rather, it is intended to assist primary care clinicians by providing a framework for clinical decision-making. It is not intended to replace clinical judgment or establish a protocol for all children with this condition. These recommendations may not provide the only appropriate approach to the management of this

  3. School Start Times for Middle School and High School Students - United States, 2011-12 School Year.

    Science.gov (United States)

    Wheaton, Anne G; Ferro, Gabrielle A; Croft, Janet B

    2015-08-07

    Adolescents who do not get enough sleep are more likely to be overweight; not engage in daily physical activity; suffer from depressive symptoms; engage in unhealthy risk behaviors such as drinking, smoking tobacco, and using illicit drugs; and perform poorly in school. However, insufficient sleep is common among high school students, with less than one third of U.S. high school students sleeping at least 8 hours on school nights. In a policy statement published in 2014, the American Academy of Pediatrics (AAP) urged middle and high schools to modify start times as a means to enable students to get adequate sleep and improve their health, safety, academic performance, and quality of life. AAP recommended that "middle and high schools should aim for a starting time of no earlier than 8:30 a.m.". To assess state-specific distributions of public middle and high school start times and establish a pre-recommendation baseline, CDC and the U.S. Department of Education analyzed data from the 2011-12 Schools and Staffing Survey (SASS). Among an estimated 39,700 public middle, high, and combined schools* in the United States, the average start time was 8:03 a.m. Overall, only 17.7% of these public schools started school at 8:30 a.m. or later. The percentage of schools with 8:30 a.m. or later start times varied greatly by state, ranging from 0% in Hawaii, Mississippi, and Wyoming to more than three quarters of schools in Alaska (76.8%) and North Dakota (78.5%). A school system start time policy of 8:30 a.m. or later provides teenage students the opportunity to achieve the 8.5-9.5 hours of sleep recommended by AAP and the 8-10 hours recommended by the National Sleep Foundation.

  4. Restrictive Palivizumab Use Does Not Lead to Increased Morbidity and Mortality in Pediatric Hematopoietic Stem Cell Transplantation Patients.

    Science.gov (United States)

    Teusink-Cross, Ashley; Davies, Stella M; Danziger-Isakov, Lara; El-Bietar, Javier; Grimley, Michael S

    2016-10-01

    Respiratory syncytial virus (RSV) is a common cause of infection in immunocompromised patients and can lead to significant morbidity and mortality in pediatric hematopoietic stem cell transplantation (HSCT) patients and patients with a primary immune deficiency (PID). Palivizumab is a humanized monoclonal antibody that targets the F glycoprotein on the surface of the RSV virus, preventing RSV replication. Palivizumab was initially licensed for the prevention of RSV infections in children at high risk of severe disease. Since licensure, the American Academy of Pediatrics (AAP) has issued guidelines to help ensure appropriate use of palivizumab in pediatric patients. In the 2014 edition of the guidelines, the AAP recognizes that severe and fatal disease secondary to RSV can be seen in patients receiving chemotherapy or patients who are immunocompromised because of other conditions. However, they recognize that no large clinical trials exist to support the use of palivizumab, and efficacy and safety data in this population are limited. Despite this, the AAP recommends considering prophylaxis for children younger than 24 months who are profoundly immunocompromised during the RSV season. Because of the high cost of palivizumab, the uncertainty of its efficacy as prophylaxis in hospitalized pediatric HSCT and PID patients, and secondary to recent data from our center that suggested immunocompromised patients diagnosed with RSV did not have worse outcomes, we implemented very restrictive criteria for the use of palivizumab in the 2015 to 2016 RSV season in our pediatric HSCT population. Despite these strict criteria, there was no change in the number of patients developing RSV during this season compared with previous seasons, and there was no change in RSV course in those patients developing RSV compared with previous seasons. Restricted use also resulted in a significant dose and cost savings. Based on our experience, we recommend only administering prophylaxis

  5. Parental leave for residents and pediatric training programs.

    Science.gov (United States)

    2013-02-01

    The American Academy of Pediatrics (AAP) is committed to the development of rational, equitable, and effective parental leave policies that are sensitive to the needs of pediatric residents, families, and developing infants and that enable parents to spend adequate and good-quality time with their young children. It is important for each residency program to have a policy for parental leave that is written, that is accessible to residents, and that clearly delineates program practices regarding parental leave. At a minimum, a parental leave policy for residents and fellows should conform legally with the Family Medical Leave Act as well as with respective state laws and should meet institutional requirements of the Accreditation Council for Graduate Medical Education for accredited programs. Policies should be well formulated and communicated in a culturally sensitive manner. The AAP advocates for extension of benefits consistent with the Family Medical Leave Act to all residents and interns beginning at the time that pediatric residency training begins. The AAP recommends that regardless of gender, residents who become parents should be guaranteed 6 to 8 weeks, at a minimum, of parental leave with pay after the infant's birth. In addition, in conformance with federal law, the resident should be allowed to extend the leave time when necessary by using paid vacation time or leave without pay. Coparenting, adopting, or fostering of a child should entitle the resident, regardless of gender, to the same amount of paid leave (6-8 weeks) as a person who takes maternity/paternity leave. Flexibility, creativity, and advanced planning are necessary to arrange schedules that optimize resident education and experience, cultivate equity in sharing workloads, and protect pregnant residents from overly strenuous work experiences at critical times of their pregnancies.

  6. Torradoviruses are transmitted in a semi-persistent and stylet-borne manner by three whitefly vectors.

    Science.gov (United States)

    Verbeek, Martin; van Bekkum, Petra J; Dullemans, Annette M; van der Vlugt, René A A

    2014-06-24

    Members of the genus Torradovirus (family Secoviridae, type species Tomato torrado virus, ToTV) are spherical plant viruses transmitted by the whitefly species Trialeurodes vaporariorum and Bemisia tabaci. Knowledge on the mode of vector transmission is lacking for torradoviruses. Here, the mode of transmission was determined for Tomato marchitez virus (ToMarV). A minimal acquisition access period (AAP) and inoculation access period (IAP) of approximately 2h each was required for its transmission by T. vaporariorum, while optimal transmission required an AAP and IAP of at least 16h and 8h, respectively. Whiteflies could retain the virus under non-feeding conditions for at least 8h without loss of transmission efficiency, but upon feeding on a non-host plant in between the AAP and IAP they retained the virus for no more than 8h. Similar conditions supported transmission of isolates of ToTV and Tomato chocolàte virus (ToChV) by T. vaporariorum and B. tabaci. Additionally, similar experiments revealed the banded-winged whitefly (Trialeurodes abutilonea) as a vector for all three virus species. The results are congruent with acquisition and retention periods for semi-persistent virus transmission. RT-PCR detection analysis of ToTV and ToMarV in the vector's body revealed their presence in the stylet, but not in the head where the pharynx of the foregut is located. The results altogether indicate a semi-persistent stylet-borne mode of vector transmission for torradoviruses. Additionally, this is the first group of spherical viruses transmitted by at least three different species of whiteflies.

  7. Enhanced Acquisition Rates of 'Candidatus Liberibacter asiaticus' by the Asian Citrus Psyllid (Hemiptera: Liviidae) in the Presence of Vegetative Flush Growth in Citrus.

    Science.gov (United States)

    Sétamou, Mamoudou; Alabi, Olufemi J; Kunta, Madhurababu; Jifon, John L; da Graça, John V

    2016-10-01

    The Asian citrus psyllid preferentially feeds and exclusively reproduces on young, newly emerged flush shoots of citrus. Asian citrus psyllid nymphs feed and complete their life stages on these flush shoots. Recent studies conducted under greenhouse conditions have shown that the transmission rates of 'Candidatus Liberibacter asiaticus' (CLas), the putative causal agent of huanglongbing disease of citrus, are enhanced when flush shoots are present. However, it is unclear if CLas acquisition by migrant adult Asian citrus psyllids is similarly enhanced. To address this knowledge gap, cohorts of Asian citrus psyllid adults were allowed 1-wk acquisition access period (AAP) on flushing and nonflushing shoots of qPCR-tested symptomatic (CLas+) and asymptomatic (CLas-) 10-yr-old sweet orange trees under field conditions. After the AAP, they were tested for CLas by qPCR. Progeny Asian citrus psyllid adults that emerged 4 wk post-AAP were similarly retrieved and tested. Eighty percent of flushing and 30% of nonflushing CLas+ trees produced infective Asian citrus psyllid adults, indicating that flush shoots have greater potential to be inoculum sources for CLas acquisition. Concomitantly, 21.1% and 6.0% infective adults were retrieved, respectively, from flushing and nonflushing CLas+ trees, indicating that Asian citrus psyllid adults acquire CLas more efficiently from flush shoots relative to mature shoots. In addition, 12.1% of infective Asian citrus psyllid adult progeny were obtained from 70% of flushing CLas+ trees. Significantly lower mean Ct values were also obtained from infective adults retrieved from flushing relative to nonflushing trees. The results underscore the role of flush shoots in CLas acquisition and the need to protect citrus trees from Asian citrus psyllid infestations during flush cycles.

  8. Comparison of polysaccharides of Haliotis discus hannai and Volutharpa ampullacea perryi by PMP-HPLC-MS(n) analysis upon acid hydrolysis.

    Science.gov (United States)

    Wang, Hongxu; Zhao, Jun; Li, Dongmei; Wen, Chengrong; Liu, Haiman; Song, Shuang; Zhu, Beiwei

    2015-10-13

    Haliotis discus hannai Ino (Haliotis) is a highly valued marine shellfish, and it is sometimes replaced by another cheaper Gastropoda mollusk, Volutharpa ampullacea perryi (Volutharpa). Polysaccharides from pleopods, viscera and gonads of these two gastropods were compared by analyzing the mono- and di-saccharides in their acid hydrolysates using high performance liquid chromatography-mass spectrometry (HPLC-MS(n)) after 1-phenyl-3-methyl-5-pyrazolone (PMP) derivatization. Disaccharide analysis revealed the distribution of uronic acid-containing polysaccharides (UACPs) in the biological samples. GlcA-(1 → 2)-Man, GlcA-(1 → 3)-GalN, and another disaccharide consisting of a hexuronic acid linked to a hexose were found in the hydrolysates, which indicated the existence of AGSP (abalone gonad sulfated polysaccharide) with the backbone composed of → 2)-α-Man(1 → 4)-β-GlcA(1 → repeating unit, AAP (abalone glycosaminoglycan-like polysaccharide) with the backbone of → 3)-GalNAc-(1 → 2)-GlcA-(1 → 3)-GalNAc-(1 → 4)-GlcA-(1 → repeating unit, and unidentified DS1P containing a hexuronic acid linked to a hexose unit, respectively. As shown by extracted ion chromatograms (XICs), AAP was the only UACP found in pleopods of the two gastropods; gonads and viscera of Haliotis contained DS1P and AGSP, while those of Volutharpa contained DS1P, AGSP as well as AAP. Monosaccharides in the acid hydrolysates were demonstrated in XICs by extracting their corresponding PMP derivative quasi-molecular ions one by one, and the results indicated the similar conclusion to the disaccharide analysis. Therefore, it could be concluded that polysaccharides from pleopods of the two gastropods are very similar, while those from their viscera and gonads differ greatly.

  9. Intramolecular and intermolecular hydrogen-bonding effects on photophysical properties of 2'-aminoacetophenone and its derivatives in solution.

    Science.gov (United States)

    Shimada, Hirofumi; Nakamura, Akihito; Yoshihara, Toshitada; Tobita, Seiji

    2005-04-01

    Effects of intra- and intermolecular hydrogen-bonds on the photophysical properties of 2'-aminoacetophenone derivatives (X-C6H4-COCH3) having a substituted amino group (X) with different hydrogen-bonding ability to the carbonyl oxygen (X: NH2(AAP), NHCH3(MAAP), N(CH3)2(DMAAP), NHCOCH3(AAAP), NHCOCF3(TFAAP)) are investigated by means of steady-state and time-resolved fluorescence spectroscopy and time-resolved thermal lensing. Based on the photophysical parameters obtained in aprotic solvents with different polarity and protic solvents with different hydrogen-bonding ability, the characteristic photophysical behavior of the 2'-aminoacetophenone derivatives is discussed in terms of hydrogen-bonding and n,pi*-pi,pi* vibronic coupling. The dominant deactivation process of AAP and MAAP in nonpolar aprotic solvents is the extremely fast internal conversion (k(ic)= 1.0 x 10(11) s(-1) for AAP and 3.9 x 10(10) s(-1) for MAAP in n-hexane). The internal conversion rates of both compounds decrease markedly with increasing solvent polarity, suggesting that vibronic interactions between close-lying S1(pi,pi*) and S2(n,pi*) states lead to the large increase in the non-radiative decay rate of the lowest excited singlet state. It is also suggested that for MAAP, which has a stronger hydrogen-bond as compared to AAP, an intramolecular hydrogen-bonding induced deactivation is involved in the dissipation of the S1 state. For DMAAP, which cannot possess an intramolecular hydrogen-bond, the primary relaxation mechanism of the S1 state in nonpolar aprotic solvents is the intersystem crossing to the triplet state, whereas in protic solvents very efficient internal conversion due to intermolecular hydrogen-bonding is induced. In contrast, the fluorescence spectra of AAAP and TFAAP, which have an amino group with a much stronger hydrogen-bonding ability, give strongly Stokes-shifted fluorescence, indicating that these compounds undergo excited-state intramolecular proton transfer reaction

  10. Uus kuum Eesti disain / Silvia Pärmann, Maris Takk

    Index Scriptorium Estoniae

    Pärmann, Silvia

    2015-01-01

    Karl Tauli disainitud taburet "Ämblu", Aap Piho puidust ümmargune laud, Marit Ilisoni tekkmantlid kollektsioonist "Longing for Sleep/Magada tahaks", Narma vaibakollektsioon "OPEN 2015/16" (disainerid Monika Järg, Kaidi Ploomipuu), Annike Laigo vaibakollektsioon "XX", Kairi Katmanni vaip "Storytellers", Valhalla Factory kollektsiooni "Daydreamers" ripptool, Raili Keivi betoonist ja portselanist nõudekollektsioon, Tarmo Luisu valgusti "Kassett", Stella Soomlaisi käekotid, Karin Kallase ja Erik Pasti (Stuudio Nahk) disainitud jalatsid, käekotid ja ehted, Kuula + Jylhä jalatsikollektsioon, Mokoko (disainer Mari Maripuu) nahast aksessuaarid

  11. Study on preparation and antigenicity activity of glycosylation products derived from whey protein and auricularia auricula polysaccharide%黑木耳多糖-乳清蛋白复合物的制备及其抗原性的研究

    Institute of Scientific and Technical Information of China (English)

    齐晓彦; 李春; 张微; 刘宁

    2012-01-01

    Protein and polysaccharide covalent complex through Maillard could form protein-polysaccharide conjugations which showed excellent properties.And the conjugates of whey protein and auricularia auricula polysaccharides(AAP)were studied by means of the dry-heating glycosylated reaction.It was shown that after the whey protein and Auricularia auricula polysaccharides(AAP)of different mass ratio reacting for different time,the antigenicity of β-LG and α-LA were estimated by indirect competition ELISA.The results indicated that the glycolsylation of whey protein could reduce the antigenicity of β-LG and α-LA.The optimum reaction condition were WPI and AAP(1:1 weight ratio)for 24 hours could reduce the antigenicity of whey protein effectively,The antigenicity of bovine milk β-LG and α-LA was reduced by conjugation with AAP,about 75.7% and 25% respectively.%蛋白质和多糖在控制条件下通过美拉德反应会发生一定程度的共价复合,能显示更优越的性能。采用黑木耳多糖作为糖基供体,用糖基化的手段与牛乳中乳清蛋白结合形成木耳多糖-乳清蛋白复合物,并在现有的条件下探索不同质量比与不同反应时间对糖基化进程的影响,采用间接竞争ELISA法测定复合物中β-乳球蛋白和α-乳白蛋白抗原性的影响。结果表明,乳清蛋白与黑木耳多糖质量比为1:1,反应时间为24h,是糖基化反应最佳条件并且能有效减低乳清蛋白抗原性,其中β-乳球蛋白抗原性降低率为75.7%,α-乳白蛋白抗原性降低率为25%。

  12. NCBI nr-aa BLAST: CBRC-CJAC-01-0928 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 91% ... ...CBRC-CJAC-01-0928 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  13. NCBI nr-aa BLAST: CBRC-CFAM-03-0005 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 83% ... ...CBRC-CFAM-03-0005 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  14. NCBI nr-aa BLAST: CBRC-TTRU-01-0295 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 86% ... ...CBRC-TTRU-01-0295 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  15. NCBI nr-aa BLAST: CBRC-HSAP-05-0018 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 99% ... ...CBRC-HSAP-05-0018 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  16. NCBI nr-aa BLAST: CBRC-FRUB-02-0029 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 1e-93 52% ... ...CBRC-FRUB-02-0029 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  17. NCBI nr-aa BLAST: CBRC-MMUR-01-1599 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 89% ... ...CBRC-MMUR-01-1599 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  18. NCBI nr-aa BLAST: CBRC-VPAC-01-1477 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 84% ... ...CBRC-VPAC-01-1477 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  19. NCBI nr-aa BLAST: CBRC-DNOV-01-2809 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 85% ... ...CBRC-DNOV-01-2809 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  20. NCBI nr-aa BLAST: CBRC-STRI-01-2861 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 88% ... ...CBRC-STRI-01-2861 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  1. NCBI nr-aa BLAST: CBRC-TNIG-12-0002 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 2e-95 46% ... ...CBRC-TNIG-12-0002 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  2. NCBI nr-aa BLAST: CBRC-TBEL-01-2493 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 1e-116 90% ... ...CBRC-TBEL-01-2493 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  3. NCBI nr-aa BLAST: CBRC-PTRO-06-0019 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 99% ... ...CBRC-PTRO-06-0019 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  4. NCBI nr-aa BLAST: CBRC-OLAT-09-0012 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 8e-93 50% ... ...CBRC-OLAT-09-0012 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  5. EST Table: BY916307 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BY916307 mg0096 10/09/28 55 %/142 aa gb|AAP42818.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18271.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18284.1| NADH dehydrog...enase subunit 6 [Bombyx mandarina] gb|ADE18388.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE1855...7.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18583.1| NADH dehydrog...enase subunit 6 [Bombyx mandarina] gb|ADE18661.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE1871

  6. EST Table: BB990129 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available one) activity)|GO:0055114(oxidation reduction) 10/09/28 49 %/157 aa gb|AAP42818.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18271.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18284.1| NADH de...hydrogenase subunit 6 [Bombyx mandarina] gb|ADE18388.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18557.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18583.1| NADH de...hydrogenase subunit 6 [Bombyx mandarina] gb|ADE18661.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|A

  7. EST Table: AU000518 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AU000518 e40637 10/09/28 50 %/162 aa gb|AAP42818.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18271.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18284.1| NADH dehydrog...enase subunit 6 [Bombyx mandarina] gb|ADE18388.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE1855...7.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18583.1| NADH dehydrog...enase subunit 6 [Bombyx mandarina] gb|ADE18661.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE1871

  8. EST Table: BB983718 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BB983718 ovS3024C07r 10/09/28 47 %/160 aa gb|AAP42818.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18271.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18284.1| NADH deh...ydrogenase subunit 6 [Bombyx mandarina] gb|ADE18388.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|AD...E18557.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18583.1| NADH deh...ydrogenase subunit 6 [Bombyx mandarina] gb|ADE18661.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|AD

  9. EST Table: BB983048 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BB983048 ovS3015B10r 10/09/28 46 %/157 aa gb|AAP42818.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18271.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18284.1| NADH deh...ydrogenase subunit 6 [Bombyx mandarina] gb|ADE18388.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|AD...E18557.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18583.1| NADH deh...ydrogenase subunit 6 [Bombyx mandarina] gb|ADE18661.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|AD

  10. EST Table: DN985187 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available DN985187 EST01033 10/09/28 51 %/157 aa gb|AAP42818.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18271.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18284.1| NADH dehydr...ogenase subunit 6 [Bombyx mandarina] gb|ADE18388.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18...557.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18583.1| NADH dehydr...ogenase subunit 6 [Bombyx mandarina] gb|ADE18661.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18

  11. EST Table: DN237519 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available DN237519 EST00645 10/09/29 49 %/159 aa gb|AAP42818.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18271.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18284.1| NADH dehydr...ogenase subunit 6 [Bombyx mandarina] gb|ADE18388.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18...557.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18583.1| NADH dehydr...ogenase subunit 6 [Bombyx mandarina] gb|ADE18661.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18

  12. EST Table: BP181108 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BP181108 ovS324C07f 10/09/28 45 %/160 aa gb|AAP42818.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18271.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18284.1| NADH dehy...drogenase subunit 6 [Bombyx mandarina] gb|ADE18388.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE...18557.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18583.1| NADH dehy...drogenase subunit 6 [Bombyx mandarina] gb|ADE18661.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE

  13. 国际风云

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    韩投资建IT中心 欲成全球RFID巨头;80%的公司缺少RFID人才;多家医疗机构使用RFID技术进行资产管理;亚洲项目实施工作组(AAP)正式启动;EPCglobal成立实用标签性能工作组;思科与欧洲RFID中心共推基于IP的RFID设备。

  14. Glossary of Terms and Definitions Concerning the Safety and Suitability for Service of Munitions, Explosives and Related Products (Glossaire de Termes et Definitions sur la Securite et L’Aptitude au Service de Munitions, Matieres Explosives et Produits Associes)

    Science.gov (United States)

    2002-04-01

    only be included if it has significance in the AC/310 field. b. The need for creation of a new term or definition must be evident. Consequently, a term...other control element. (AAP/6) [gas actuator] servocommande Dispositif fournissant la force nécessaire au déplacement d’une gouverne ou de... Valeur d’un stimulus dans des conditions spécifiées, le fonctionnement d’une matière explosive ou d’un composant pyrotechnique, avec une probabilité

  15. NCBI nr-aa BLAST: CBRC-CFAM-15-0035 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CFAM-15-0035 ref|NP_006165.1| neuropeptide Y receptor Y5 [Homo sapiens] ref|XP..._001148404.1| PREDICTED: neuropeptide Y receptor Y5 isoform 1 [Pan troglodytes] gb|AAC50741.1| neuropeptide ...Y5 receptor gb|AAC51295.1| neuropeptide Y5 receptor [Homo sapiens] gb|AAH42416.1| Neuropeptide Y receptor Y5... [Homo sapiens] gb|AAP84351.1| neuropeptide Y receptor Y5 [Homo sapiens] gb|EAX04839.1| neurope

  16. NCBI nr-aa BLAST: CBRC-RMAC-05-0035 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RMAC-05-0035 ref|NP_006165.1| neuropeptide Y receptor Y5 [Homo sapiens] ref|XP..._001148404.1| PREDICTED: neuropeptide Y receptor Y5 isoform 1 [Pan troglodytes] gb|AAC50741.1| neuropeptide ...Y5 receptor gb|AAC51295.1| neuropeptide Y5 receptor [Homo sapiens] gb|AAH42416.1| Neuropeptide Y receptor Y5... [Homo sapiens] gb|AAP84351.1| neuropeptide Y receptor Y5 [Homo sapiens] gb|EAX04839.1| neurope

  17. NCBI nr-aa BLAST: CBRC-BTAU-01-0916 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-0916 ref|NP_006165.1| neuropeptide Y receptor Y5 [Homo sapiens] ref|XP..._001148404.1| PREDICTED: neuropeptide Y receptor Y5 isoform 1 [Pan troglodytes] gb|AAC50741.1| neuropeptide ...Y5 receptor gb|AAC51295.1| neuropeptide Y5 receptor [Homo sapiens] gb|AAH42416.1| Neuropeptide Y receptor Y5... [Homo sapiens] gb|AAP84351.1| neuropeptide Y receptor Y5 [Homo sapiens] gb|EAX04839.1| neurope

  18. NCBI nr-aa BLAST: CBRC-BTAU-01-1399 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-1399 ref|NP_006165.1| neuropeptide Y receptor Y5 [Homo sapiens] ref|XP..._001148404.1| PREDICTED: neuropeptide Y receptor Y5 isoform 1 [Pan troglodytes] gb|AAC50741.1| neuropeptide ...Y5 receptor gb|AAC51295.1| neuropeptide Y5 receptor [Homo sapiens] gb|AAH42416.1| Neuropeptide Y receptor Y5... [Homo sapiens] gb|AAP84351.1| neuropeptide Y receptor Y5 [Homo sapiens] gb|EAX04839.1| neurope

  19. NCBI nr-aa BLAST: CBRC-FCAT-01-1069 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FCAT-01-1069 ref|NP_006165.1| neuropeptide Y receptor Y5 [Homo sapiens] ref|XP..._001148404.1| PREDICTED: neuropeptide Y receptor Y5 isoform 1 [Pan troglodytes] gb|AAC50741.1| neuropeptide ...Y5 receptor gb|AAC51295.1| neuropeptide Y5 receptor [Homo sapiens] gb|AAH42416.1| Neuropeptide Y receptor Y5... [Homo sapiens] gb|AAP84351.1| neuropeptide Y receptor Y5 [Homo sapiens] gb|EAX04839.1| neurope

  20. NCBI nr-aa BLAST: CBRC-XTRO-01-3658 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-3658 ref|NP_006165.1| neuropeptide Y receptor Y5 [Homo sapiens] ref|XP..._001148404.1| PREDICTED: neuropeptide Y receptor Y5 isoform 1 [Pan troglodytes] gb|AAC50741.1| neuropeptide ...Y5 receptor gb|AAC51295.1| neuropeptide Y5 receptor [Homo sapiens] gb|AAH42416.1| Neuropeptide Y receptor Y5... [Homo sapiens] gb|AAP84351.1| neuropeptide Y receptor Y5 [Homo sapiens] gb|EAX04839.1| neurope

  1. NCBI nr-aa BLAST: CBRC-MMUS-08-0030 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-08-0030 ref|NP_006165.1| neuropeptide Y receptor Y5 [Homo sapiens] ref|XP..._001148404.1| PREDICTED: neuropeptide Y receptor Y5 isoform 1 [Pan troglodytes] gb|AAC50741.1| neuropeptide ...Y5 receptor gb|AAC51295.1| neuropeptide Y5 receptor [Homo sapiens] gb|AAH42416.1| Neuropeptide Y receptor Y5... [Homo sapiens] gb|AAP84351.1| neuropeptide Y receptor Y5 [Homo sapiens] gb|EAX04839.1| neurope

  2. NCBI nr-aa BLAST: CBRC-BTAU-01-0832 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-0832 ref|NP_006165.1| neuropeptide Y receptor Y5 [Homo sapiens] ref|XP..._001148404.1| PREDICTED: neuropeptide Y receptor Y5 isoform 1 [Pan troglodytes] gb|AAC50741.1| neuropeptide ...Y5 receptor gb|AAC51295.1| neuropeptide Y5 receptor [Homo sapiens] gb|AAH42416.1| Neuropeptide Y receptor Y5... [Homo sapiens] gb|AAP84351.1| neuropeptide Y receptor Y5 [Homo sapiens] gb|EAX04839.1| neurope

  3. NCBI nr-aa BLAST: CBRC-CJAC-01-1627 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CJAC-01-1627 ref|NP_006165.1| neuropeptide Y receptor Y5 [Homo sapiens] ref|XP..._001148404.1| PREDICTED: neuropeptide Y receptor Y5 isoform 1 [Pan troglodytes] gb|AAC50741.1| neuropeptide ...Y5 receptor gb|AAC51295.1| neuropeptide Y5 receptor [Homo sapiens] gb|AAH42416.1| Neuropeptide Y receptor Y5... [Homo sapiens] gb|AAP84351.1| neuropeptide Y receptor Y5 [Homo sapiens] gb|EAX04839.1| neurope

  4. NCBI nr-aa BLAST: CBRC-ETEL-01-1098 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-1098 ref|NP_006165.1| neuropeptide Y receptor Y5 [Homo sapiens] ref|XP..._001148404.1| PREDICTED: neuropeptide Y receptor Y5 isoform 1 [Pan troglodytes] gb|AAC50741.1| neuropeptide ...Y5 receptor gb|AAC51295.1| neuropeptide Y5 receptor [Homo sapiens] gb|AAH42416.1| Neuropeptide Y receptor Y5... [Homo sapiens] gb|AAP84351.1| neuropeptide Y receptor Y5 [Homo sapiens] gb|EAX04839.1| neurope

  5. NCBI nr-aa BLAST: CBRC-OANA-01-2229 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OANA-01-2229 ref|NP_006165.1| neuropeptide Y receptor Y5 [Homo sapiens] ref|XP..._001148404.1| PREDICTED: neuropeptide Y receptor Y5 isoform 1 [Pan troglodytes] gb|AAC50741.1| neuropeptide ...Y5 receptor gb|AAC51295.1| neuropeptide Y5 receptor [Homo sapiens] gb|AAH42416.1| Neuropeptide Y receptor Y5... [Homo sapiens] gb|AAP84351.1| neuropeptide Y receptor Y5 [Homo sapiens] gb|EAX04839.1| neurope

  6. NCBI nr-aa BLAST: CBRC-RNOR-16-0028 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-16-0028 ref|NP_006165.1| neuropeptide Y receptor Y5 [Homo sapiens] ref|XP..._001148404.1| PREDICTED: neuropeptide Y receptor Y5 isoform 1 [Pan troglodytes] gb|AAC50741.1| neuropeptide ...Y5 receptor gb|AAC51295.1| neuropeptide Y5 receptor [Homo sapiens] gb|AAH42416.1| Neuropeptide Y receptor Y5... [Homo sapiens] gb|AAP84351.1| neuropeptide Y receptor Y5 [Homo sapiens] gb|EAX04839.1| neurope

  7. Gene : CBRC-MMUS-11-0110 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-11-0110 pseudo Novel 11 A Odorant/olfactory and gustatory receptors OR1A1..._PANTR 2e-69 53% gb|AAP70929.1| olfactory receptor Olfr43 [Mus musculus] emb|CAI24518.1| olfactory receptor 43 [Mus musculus...] gb|AAI25465.1| Olfactory receptor 43 [Mus musculus] gb|AAI25469.1| Olfactory receptor 43 [Mus musculus...] gb|EDL12760.1| mCG1036248 [Mus musculus] 1e-81 61% gnl|UG|Mm#S35209285 Mus musculus

  8. Gene : CBRC-MMUS-11-0114 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-11-0114 11 A Odorant/olfactory and gustatory receptors OR3A1_HUMAN 1e-155... 84% ref|NP_666918.1| olfactory receptor 410 [Mus musculus] gb|AAL61051.1| olfactory receptor MOR255-5 [Mus musculus...] gb|AAP70932.1| olfactory receptor Olfr410 [Mus musculus] emb|CAI24527.1| olfactory receptor 410 [Mus musculus...] gb|EDL12768.1| mCG52814 [Mus musculus] 1e-180 100% gnl|UG|Mm#S9745013 Mus musculus

  9. Gene : CBRC-MMUS-09-0098 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-09-0098 9 A Odorant/olfactory and gustatory receptors OL147_MOUSE 1e-126 ...72% ref|NP_667015.1| olfactory receptor 905 [Mus musculus] gb|AAL60953.1| olfactory receptor MOR167-1 [Mus musculus...] gb|AAP71380.1| olfactory receptor Olfr905 [Mus musculus] gb|EDL25460.1| mCG53365 [Mus musculus] gb|...AAI50477.1| Olfactory receptor 905 [Mus musculus] 1e-173 98% gnl|UG|Mm#S39545474 Mus musculus

  10. Gene : CBRC-MMUS-07-0515 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-07-0515 7 A Odorant/olfactory and gustatory receptors O52N5_HUMAN 1e-159 ...88% ref|NP_667254.1| olfactory receptor 669 [Mus musculus] gb|AAL60708.1| olfactory receptor MOR34-6 [Mus musculus...] gb|AAP71140.1| olfactory receptor Olfr669 [Mus musculus] gb|AAI04301.1| Olfactory receptor 669 [Mus musculus...] gb|EDL16746.1| olfactory receptor 669 [Mus musculus] 0.0 100% gnl|UG|Mm#S26988998 Mus musculus

  11. Gene : CBRC-MMUS-19-0084 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-19-0084 19 A Odorant/olfactory and gustatory receptors OR9I1_HUMAN 1e-148... 82% ref|NP_667008.1| olfactory receptor 1502 [Mus musculus] gb|AAL60960.1| olfactory receptor MOR211-1 [Mus musculus...] gb|AAP71851.1| olfactory receptor Olfr1502 [Mus musculus] gb|AAI06811.1| Olfactory receptor 1502 [Mus musculus...] gb|EDL41523.1| mCG55155 [Mus musculus] 1e-180 100% gnl|UG|Mm#S27582255 Mus musculus

  12. Gene : CBRC-MMUS-02-0242 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-02-0242 2 A Odorant/olfactory and gustatory receptors OR4P4_HUMAN 1e-117 ...66% ref|NP_667034.1| olfactory receptor 1184 [Mus musculus] gb|AAL60933.1| olfactory receptor MOR225-3 [Mus musculus...] gb|AAP71595.1| olfactory receptor Olfr1184 [Mus musculus] emb|CAM17508.1| olfactory receptor 1184 [Mus musculus...L27434.1| olfactory receptor 1184 [Mus musculus] 0.0 100% gnl|UG|Mm#S9745121 Mus musculus olfactory receptor

  13. Gene : CBRC-MMUS-11-0101 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-11-0101 11 A Odorant/olfactory and gustatory receptors OR3A4_HUMAN 1e-139... 83% gb|AAP70925.1| olfactory receptor Olfr399 [Mus musculus] emb|CAI24631.1| olfactory receptor 399 [Mus musculus...] gb|AAI20847.1| Olfactory receptor 399 [Mus musculus] gb|AAI20821.1| Olfactory receptor 399 [Mus musculus...] gb|EDL12753.1| olfactory receptor 399 [Mus musculus] 1e-177 100% gnl|UG|Mm#S34285683 Mus musculus

  14. Gene : CBRC-MMUS-10-0061 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-10-0061 10 A Odorant/olfactory and gustatory receptors OR7AH_HUMAN 1e-121... 71% ref|NP_667251.1| olfactory receptor 1351 [Mus musculus] gb|AAL60711.1| olfactory receptor MOR139-4 [Mus musculus...] gb|AAP71735.1| olfactory receptor Olfr1351 [Mus musculus] gb|AAI04113.1| Olfactory receptor 1351 [Mus musculus...] gb|EDL31709.1| mCG52449 [Mus musculus] 1e-180 100% gnl|UG|Mm#S26988969 Mus musculus

  15. Gene : CBRC-MMUS-07-0414 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-07-0414 7 A Odorant/olfactory and gustatory receptors O51A7_HUMAN 1e-133 ...76% ref|NP_667321.1| olfactory receptor 570 [Mus musculus] gb|AAL60639.1| olfactory receptor MOR8-3 [Mus musculus...] gb|AAP71060.1| olfactory receptor Olfr570 [Mus musculus] gb|AAI16967.1| Olfactory receptor 570 [Mus musculus...] gb|EDL16635.1| olfactory receptor 570 [Mus musculus] 1e-175 100% gnl|UG|Mm#S33850657 Mus mus

  16. New insights into the tectonic evolution of the Andaman basin, northeast Indian Ocean

    Digital Repository Service at National Institute of Oceanography (India)

    KameshRaju, K.A.; Ramprasad, T.; Rao, P.S.; Rao, B.R.; Varghese, J.

    lines represent absence of magnetics, dashed lines AAP and BBP seismic re£ection data. EPSL 7024 25-3-04 Cyaan Magenta Geel Zwart K.A. Kamesh Raju et al./Earth and Planetary Science Letters 221 (2004) 145^162146 Andaman island arc including the Andaman... to inad- equate geophysical data. We aim to infer the evo- lution of the backarc basin based on multibeam bathymetry, magnetic and single channel seismic re£ection data acquired as a part of the investiga- tions to explore the possible occurrence of hydro...

  17. Uus tootedisain = New product design / Monika Järg

    Index Scriptorium Estoniae

    Järg, Monika, 1975-

    2012-01-01

    Tutvustatakse: mööblisari Smart (Tarmo Luisk, 2011) ja Slice (Tarmo Luisk, 2008), rattahoidja Typo (Tarmo Luisk) ja Tulip Fan Fan (Margus Triibmann, 2011), iste Seat (Monika Järg), mööbliseeria Maast: tool CHO1 ja laud TBO1 (Tõnis Kalve, Aap Piho, 2011), padjad KO! (Kärt Ojavee, 2011), vaibakollektsioon Unlimited (Kaidi Ploomipuu, Monika Järg, 2011), vann Aquator CLAUDE 170 (2011), büroomööbli seeria Metod (Iseasi, 2012), rippvalgusti Aero (Tõnis Vellama, 2011), tool Must ja nagi Z (Toivo Raidmets, 2008-2012)

  18. Dicty_cDB: Contig-U01624-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Z383766 ) 1M0141J01R Mouse 10kb plasmid UUGC1M library Mus ... 44 9.5 1 ( CU571945 ) Theobroma cacao, mRNA s...equence (KZ0AAP13YJ11FM1). 44 9.5 1 ( CU546001 ) Theobroma cacao, mRNA sequence (KZ0AA1YG07). 44 9.5 1 ( CU510372 ) Theobroma cacao,... mRNA sequence (KZ0ACM3YD21FM1). 44 9.5 1 ( CU479362 ) Theobroma cacao,

  19. NCBI nr-aa BLAST: CBRC-GGOR-01-1322 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GGOR-01-1322 ref|NP_060106.2| transient receptor potential cation channel, sub...annel subfamily M member 4; AltName: Full=Long transient receptor potential channel 4; Short=LTrpC4; Short=h...cation channel 1 gb|AAM18083.1|AF497623_1 cation channel TRPM4B [Homo sapiens] gb|AAP44474.1| transient rece...ptor potential cation channel subfamily M member 4 splice variant B [Homo sapiens] emb|CAE05941.1| transient

  20. The Apollo Accreditation Program: A web-based Joint Commission International standards compliance management tool.

    Science.gov (United States)

    Dewan, Shaveta; Sibal, Anupam; Uberoi, R S; Kaur, Ishneet; Nayak, Yogamaya; Kar, Sujoy; Loria, Gaurav; Yatheesh, G; Balaji, V

    2014-01-01

    Creating and implementing processes to deliver quality care in compliance with accreditation standards is a challenging task but even more daunting is sustaining these processes and systems. There is need for frequent monitoring of the gap between the expected level of care and the level of care actually delivered so as to achieve consistent level of care. The Apollo Accreditation Program (AAP) was implemented as a web-based single measurable dashboard to display, measure and compare compliance levels for established standards of care in JCI accredited hospitals every quarter and resulted in an overall 15.5% improvement in compliance levels over one year.

  1. Papel dos proteassomas na interação e desenvolvimento de Leishmania chagasi em macrófagos murinos.

    OpenAIRE

    Izaltina Silva Jardim

    2001-01-01

    Nas células eucariotas a maioria das proteínas citoplasmáticas não são degradadas nos lisossomas, mas em organelas altamente conservadas encontradas em humanos, arquibactérias, plantas e leveduras, os proteassomas. Esta estrutura multicatalítica é constituída por componentes menores, cujo núcleo funcional é o componente 20S, que contém várias atividades proteolíticas (tríptica, quimotríptica, de peptidilglutamil peptidase, BrAAP e SNAAP). Esse componente 20S, associado ao complexo regulatório...

  2. Novedades en alimentación complementaria Novelties in complementary feeding

    OpenAIRE

    Marugán de Miguelsanz, J. M.

    2010-01-01

    La alimentación complementaria o beikost, son los términos clásicamente utilizados para referirnos a todos los alimentos, que no sean la leche humana ni la procedente de fórmula adaptada, utilizados en la alimentación del lactante, y esenciales.
    Desde el establecimiento de las recomendaciones históricas sobre alimentación complementaria realizadas por la Academia Americana de Pediatría (AAP) y seguidamente por la Sociedad Europea de Gastroenterología, Hepatología y Nutrición Pediá...

  3. NCBI nr-aa BLAST: CBRC-ETEL-01-0465 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0465 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  4. NCBI nr-aa BLAST: CBRC-GACU-07-0011 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GACU-07-0011 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  5. NCBI nr-aa BLAST: CBRC-XTRO-01-2768 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-2768 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  6. NCBI nr-aa BLAST: CBRC-OCUN-01-1620 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OCUN-01-1620 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  7. NCBI nr-aa BLAST: CBRC-ETEL-01-1373 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-1373 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  8. NCBI nr-aa BLAST: CBRC-ACAR-01-0438 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ACAR-01-0438 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  9. NCBI nr-aa BLAST: CBRC-HSAP-04-0027 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-HSAP-04-0027 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  10. NCBI nr-aa BLAST: CBRC-DRER-07-0072 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DRER-07-0072 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  11. NCBI nr-aa BLAST: CBRC-CBRE-01-0701 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CBRE-01-0701 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  12. NCBI nr-aa BLAST: CBRC-FCAT-01-1015 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FCAT-01-1015 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  13. NCBI nr-aa BLAST: CBRC-MMUS-05-0020 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-05-0020 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  14. NCBI nr-aa BLAST: CBRC-PTRO-05-0018 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PTRO-05-0018 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  15. NCBI nr-aa BLAST: CBRC-PABE-05-0014 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PABE-05-0014 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  16. NCBI nr-aa BLAST: CBRC-CFAM-03-0027 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CFAM-03-0027 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  17. NCBI nr-aa BLAST: CBRC-OLAT-18-0070 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OLAT-18-0070 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  18. NCBI nr-aa BLAST: CBRC-RMAC-05-0007 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RMAC-05-0007 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  19. NCBI nr-aa BLAST: CBRC-ETEL-01-0940 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0940 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  20. NCBI nr-aa BLAST: CBRC-CJAC-01-1653 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CJAC-01-1653 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  1. NCBI nr-aa BLAST: CBRC-TGUT-06-0015 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TGUT-06-0015 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  2. NCBI nr-aa BLAST: CBRC-GGAL-04-0036 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GGAL-04-0036 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  3. NCBI nr-aa BLAST: CBRC-CPOR-01-1990 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CPOR-01-1990 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  4. NCBI nr-aa BLAST: CBRC-BTAU-01-2281 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-2281 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  5. NCBI nr-aa BLAST: CBRC-CBRE-01-1028 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CBRE-01-1028 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  6. NCBI nr-aa BLAST: CBRC-LAFR-01-0624 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0624 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  7. NCBI nr-aa BLAST: CBRC-GACU-16-0038 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GACU-16-0038 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  8. NCBI nr-aa BLAST: CBRC-CBRE-01-1053 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CBRE-01-1053 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  9. NCBI nr-aa BLAST: CBRC-DRER-01-0042 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DRER-01-0042 ref|NP_000721.1| cholecystokinin A receptor [Homo sapiens] sp|P32238|CCKAR_HUMAN Chole...cystokinin type A receptor (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) gb|AAA35659.1| chole...cystokinin A receptor gb|AAA02819.1| cholecystokinin A receptor gb|AAA91123.1| chole...cystokinin type A receptor dbj|BAA90879.1| cholecystokinin type-A receptor [Homo ...sapiens] gb|AAP84362.1| cholecystokinin A receptor [Homo sapiens] gb|AAH74987.1| Cholecystokinin A receptor

  10. Adhesive properties of Staphylococcus epidermidis probed by atomic force microscopy

    DEFF Research Database (Denmark)

    Hu, Yifan; Ulstrup, Jens; Zhang, Jingdong;

    2011-01-01

    Mapping of the surface properties of Staphylococcus epidermidis and of biofilm forming bacteria in general is a key to understand their functions, particularly their adhesive properties. To gain a comprehensive view of the structural and chemical properties of S. epidermidis, four different strains...... are not the driving forces for adhesion of the four strains. Rather, the observation of sawtooth force–distance patterns on the surface of biofilm positive strains documents the presence of modular proteins such as Aap that may mediate cell adhesion. Treatment of two biofilm positive strains with two chemical...

  11. Application of acid-treated yeast cell wall (AYC) as a pharmaceutical additive. III. AYC aqueous coating onto granules and film formation mechanism of AYC.

    Science.gov (United States)

    Yuasa, Hiroshi; Kaneshige, Junichi; Ozeki, Tetsuya; Kasai, Takahide; Eguchi, Takahiro; Ishiwaki, Naomu

    2002-04-26

    From the viewpoint of effective utilization of natural resources and development of new pharmaceutical materials, acid-treated yeast cell wall (AYC) was prepared via a novel approach involving acidification of brewers' yeast cell wall. AYC aqueous dispersion containing 5% (w/v) AYC and 0.5% (w/v) glycerol was prepared. Subsequently, AYC was coated onto core granules containing acetaminophen (AAP). Spray mist size under various spray conditions and viscosity of the AYC aqueous dispersion at various AYC concentrations were measured. AYC spray mists were optically observed. The surface of AYC cast film and AYC-coated granules were observed with a confocal scanning laser microscope. We attempted to show the utility of AYC as a novel material for granule coating, following the tablet coating in our previous report. In addition, the film formation mechanism of AYC was investigated. A smooth surface of the AYC-coated granules was obtained at a coating ratio of only 5%, which generally requires approximately 15-30% coating against the core granule weight, with no aggregation. These results are attributable to the fact that the granules were coated with a large number of small mists of AYC and the coating progressed efficiently, and the thin film layer of AYC was formed on the granules by mutual tangling of the hydrogel layers of AYC polysaccharides. AAP release from AYC-coated granules was obviously rapid, suggesting the high utility of AYC as a coating material for the rapidly releasing granules.

  12. Effects of intracerebroventricular (ICV) olanzapine on insulin sensitivity and secretion in vivo: an animal model.

    Science.gov (United States)

    Hahn, Margaret K; Chintoh, Araba; Remington, Gary; Teo, Celine; Mann, Steve; Arenovich, Tamara; Fletcher, Paul; Lam, Loretta; Nobrega, Jose; Guenette, Melanie; Cohn, Tony; Giacca, Adria

    2014-03-01

    The atypical antipsychotics (AAPs) have been associated with an increased risk of type 2 diabetes. While weight gain associated with AAPs is a risk factor for diabetes, preclinical work suggests that among these medications, olanzapine, when given peripherally in a single dose, causes pronounced effects on insulin sensitivity and secretion. Given a critical role of the hypothalamus in control of glucose metabolism, we examined the effect of central administration of olanzapine. Sprague-Dawley rats were treated with a single 75 μg intracerebroventricular (ICV) dose of olanzapine and tested using separate hyperinsulinemic-euglycemic and hyperglycemic clamps. Dosing of olanzapine was established based on inhibition of amphetamine-induced locomotion. In contrast to the single dosing peripheral paradigm, there was no effect of central olanzapine on insulin sensitivity, either with respect to hepatic glucose production or peripheral glucose uptake. Analogous to the peripheral model, a single ICV dose of olanzapine followed by the hyperglycemic clamp decreased insulin (p=0.0041) and C-peptide response (p=0.0039) to glucose challenge as compared to vehicle, mirrored also by a decrease in the steady state glucose infusion rate required to maintain hyperglycemia (p=0.002). In conclusion, we demonstrate novel findings that at least part of the effect of olanzapine on beta-cell function in vivo is central.

  13. Differential Gene Expression in the Meristem and during Early Fruit Growth of Pisum sativum L. Identifies Potential Targets for Breeding

    Science.gov (United States)

    Smitha Ninan, Annu; Shah, Anish; Song, Jiancheng; Jameson, Paula E.

    2017-01-01

    For successful molecular breeding it is important to identify targets to the gene family level, and in the specific species of interest, in this case Pisum sativum L. The cytokinins have been identified as a key breeding target due to their influence on plant architecture, and on seed size and sink activity. We focused on the cytokinin biosynthetic gene family (the IPTs) and the gene family key to the destruction of cytokinins (the CKXs), as well as other gene families potentially affected by changing cytokinin levels. These included key meristem genes (WUS and BAM1) and the transporter gene families, sucrose transporters (SUTs) and amino acid permeases (AAPs). We used reverse transcription quantitative PCR (RT-qPCR) to monitor gene expression in the vegetative meristem and in pre- and post-fertilisation young pea fruits. PsWUS expression was specific to the shoot apical meristem while PsBAM1 was highly expressed in the shoot apical meristem (SAM) but was also expressed at a low level in the young fruit. Differential expression was shown between genes and within gene families for IPT, CKX, SUT, and AAP. PsCKX7 showed strong gene family member-specific expression in the SAM, and was also expressed in young pea fruits. We suggest that PsCKX7 is a potential target for downregulation via molecular breeding or gene editing. PMID:28212324

  14. Differential Gene Expression in the Meristem and during Early Fruit Growth of Pisum sativum L. Identifies Potential Targets for Breeding

    Directory of Open Access Journals (Sweden)

    Annu Smitha Ninan

    2017-02-01

    Full Text Available For successful molecular breeding it is important to identify targets to the gene family level, and in the specific species of interest, in this case Pisum sativum L. The cytokinins have been identified as a key breeding target due to their influence on plant architecture, and on seed size and sink activity. We focused on the cytokinin biosynthetic gene family (the IPTs and the gene family key to the destruction of cytokinins (the CKXs, as well as other gene families potentially affected by changing cytokinin levels. These included key meristem genes (WUS and BAM1 and the transporter gene families, sucrose transporters (SUTs and amino acid permeases (AAPs. We used reverse transcription quantitative PCR (RT-qPCR to monitor gene expression in the vegetative meristem and in pre- and post-fertilisation young pea fruits. PsWUS expression was specific to the shoot apical meristem while PsBAM1 was highly expressed in the shoot apical meristem (SAM but was also expressed at a low level in the young fruit. Differential expression was shown between genes and within gene families for IPT, CKX, SUT, and AAP. PsCKX7 showed strong gene family member-specific expression in the SAM, and was also expressed in young pea fruits. We suggest that PsCKX7 is a potential target for downregulation via molecular breeding or gene editing.

  15. Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide.

    Science.gov (United States)

    Bhushan, Shashi; Meyer, Helge; Starosta, Agata L; Becker, Thomas; Mielke, Thorsten; Berninghausen, Otto; Sattler, Michael; Wilson, Daniel N; Beckmann, Roland

    2010-10-08

    Specific regulatory nascent chains establish direct interactions with the ribosomal tunnel, leading to translational stalling. Despite a wealth of biochemical data, structural insight into the mechanism of translational stalling in eukaryotes is still lacking. Here we use cryo-electron microscopy to visualize eukaryotic ribosomes stalled during the translation of two diverse regulatory peptides: the fungal arginine attenuator peptide (AAP) and the human cytomegalovirus (hCMV) gp48 upstream open reading frame 2 (uORF2). The C terminus of the AAP appears to be compacted adjacent to the peptidyl transferase center (PTC). Both nascent chains interact with ribosomal proteins L4 and L17 at tunnel constriction in a distinct fashion. Significant changes at the PTC were observed: the eukaryotic-specific loop of ribosomal protein L10e establishes direct contact with the CCA end of the peptidyl-tRNA (P-tRNA), which may be critical for silencing of the PTC during translational stalling. Our findings provide direct structural insight into two distinct eukaryotic stalling processes.

  16. Phase separation kinetics in amorphous solid dispersions upon exposure to water.

    Science.gov (United States)

    Purohit, Hitesh S; Taylor, Lynne S

    2015-05-04

    The purpose of this study was to develop a novel fluorescence technique employing environment-sensitive fluorescent probes to study phase separation kinetics in hydrated matrices of amorphous solid dispersions (ASDs) following storage at high humidity and during dissolution. The initial miscibility of the ASDs was confirmed using infrared (IR) spectroscopy and differential scanning calorimetry (DSC). Fluorescence spectroscopy, as an independent primary technique, was used together with conventional confirmatory techniques including DSC, X-ray diffraction (XRD), fluorescence microscopy, and IR spectroscopy to study phase separation phenomena. By monitoring the emission characteristics of the environment-sensitive fluorescent probes, it was possible to successfully monitor amorphous-amorphous phase separation (AAPS) as a function of time in probucol-poly(vinylpyrrolidone) (PVP) and ritonavir-PVP ASDs after exposure to water. In contrast, a ritonavir-hydroxypropylmethylcellulose acetate succinate (HPMCAS) ASD, did not show AAPS and was used as a control to demonstrate the capability of the newly developed fluorescence method to differentiate systems that showed no phase separation following exposure to water versus those that did. The results from the fluorescence studies were in good agreement with results obtained using various other complementary techniques. Thus, fluorescence spectroscopy can be utilized as a fast and efficient tool to detect and monitor the kinetics of phase transformations in amorphous solid dispersions during hydration and will help provide mechanistic insight into the stability and dissolution behavior of amorphous solid dispersions.

  17. Adult Attachment, Social Adjustment, and Well-Being in Drug-Addicted Inpatients.

    Science.gov (United States)

    Delvecchio, Elisa; Di Riso, Daniela; Lis, Adriana; Salcuni, Silvia

    2016-04-01

    In recent years, attachment studies have gathered overwhelming evidence for a relation between insecure attachment and drug addiction. The existing literature predominantly addresses attachment styles and little attention is given to attachment-pattern-oriented studies. The current study explored how attachment, social adjustment, and well-being interact in 40 (28 men, 12 women; ages 20-52 years, M = 32.3, SD = 9.4) inpatients with drug addiction. The Adult Attachment Projective Picture System (AAP), the Social Adjustment Scale-Self-report (SAS-SR), and the General Health Questionnaire-28 (GHQ-28) were administered. Descriptive statistics were computed as well as differences between patterns of attachment in all variables were measured. None of the inpatients showed a secure attachment pattern: 7 scored as dismissing (18%), 5 preoccupied (12%) and 28 unresolved (70%). AAP stories were mainly connected with themes of danger, lack of protection, and helplessness. Inpatients classified as unresolved reported significantly higher maladjustment on the SAS-SR and GHQ-28 than those with resolved attachment patterns. Implications for clinicians and researchers are presented.

  18. Attachment disorganization in different clinical groups: What underpins unresolved attachment?

    Directory of Open Access Journals (Sweden)

    Juen Florian

    2013-01-01

    Full Text Available This paper summarizes findings and clinical implications of research on attachment disorganization in diverse clinical groups. Disorganized/unresolved attachment is overrepresented in these groups compared to healthy control participants, but disorder specific characteristics of this attachment pattern are still poorly understood. The focus of this study was to explore defensive processes in participants whose narratives were classified as disorganized/unresolved using the Adult Attachment Projective Picture System (AAP. Besides the predominance of disorganized attachment, clinical participants demonstrated more “segregated system material” especially in stories representing aloneness and more “Personal Experience material” compared to healthy individuals. Within the disorganized/ unresolved clinical individuals, BPD and PTSD patients showed the highest proportion of attachment disorganization and were less able to use other attachment-related defenses to maintain organized. Furthermore, PTSD patients were emotionally overwhelmed by the projective attachment scenes compared to the other clinical groups as indexed by an incapacity to complete sections of the AAP. BPD and addicted patients were characterized by a high degree of self-other boundary confusion. Depressive and schizophrenic patients showed a high overall defensive intensity to remain organized.

  19. Biofilm characteristics of Staphylococcus epidermidis isolates associated with device-related meningitis.

    LENUS (Irish Health Repository)

    Stevens, Niall T

    2009-07-01

    Staphylococcus epidermidis biofilm causes device-related meningitis in neurosurgical patients. This study assessed the contribution of polysaccharide and protein to the development of a strong biofilm-positive phenotype in four S. epidermidis isolates associated with probable device-related meningitis, under varying environmental conditions. RT-PCR analysis of the intercellular adhesion operon (icaADBC) and assessment of polysaccharide intercellular adhesin (PIA) production indicated a correlation between increased icaA transcription and PIA production in ica(+) isolates grown in medium with 4 % ethanol and 4 % NaCl. Treatment of biofilm with sodium metaperiodate caused dispersion of adhered cells (P <0.0001), indicating involvement of PIA. Transcriptional levels of protein factors revealed that atlE transcription levels were similar in all isolates, whilst aap levels were variable, with induction being seen in two isolates following growth in the presence of alcohol or salt. Transcription of agr did not influence protein expression and RNAIII transcription varied among the strains. Although aap transcription was induced, the treatment of biofilm with proteinase K did not always disperse the biofilm. Our data suggest that, among the three ica(+) S. epidermidis isolates clinically associated with meningitis that were studied, PIA contributed to the strong biofilm-positive phenotype, whereas protein factors appeared to have a secondary role.

  20. Measuring diagnostic accuracy of imaging parameters in pelvic lipomatosis

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yudong, E-mail: pku_zyd06@163.com [Department of Radiology, Peking University First Hospital, Beijing (China); Wu, Shiliang, E-mail: wushiliangjsh@263.net [Department of Urology, Peking University First Hospital, Beijing (China); Xi, Zhijun, E-mail: xizhijun@hsc.pku.edu.cn [Department of Urology, Peking University First Hospital, Beijing (China); Wang, Xiaoying, E-mail: cjr.wangxiaoying@vip.163.com [Department of Radiology, Peking University First Hospital, Beijing (China); Jiang, Xuexiang, E-mail: cjr.jxx@vip.163.com [Department of Radiology, Peking University First Hospital, Beijing (China)

    2012-11-15

    Objectives: To study whether the individual radiological findings can help predict diagnosis of pelvic lipomatosis (PL) or, specifically appreciate its progression. Methods: Data from 32 clinically proven cases of PL and 25 controls were collected. Two reviewers were recruited for a blinded evaluation, image features were recorded in terms of: (1) bladder shape; (2) bladder-rectosigmoid morphological indexes including ratio of superior-inferior to anterior-posterior length of bladder (SI/AP), angle between anterior and posterior wall (AAP), relative length of posterior urethra (rLPU), angle between bladder and seminal vesicle (ABS) and rectosigmoid morphological index (RMI); (3) secondary complications. Results were evaluated by an unpaired t test and ROC analysis. Results: The sensitivity and specificity were 40.6% and 100% for pear and banana-shaped bladder, 62.5% and 100% for SI/AP, 40.6% and 100% for AAP, 62.5% and 100% for ABS, 78.1% and 72% for rLPU, 59.4% and 96% for RMI, respectively. These radiological findings partially correlated with the severity of disease weighted by hydronephrosis and treatment grade. Image analysis demonstrated high prevalence of glandular cystitis (100%) and hydronephrosis (73.4%). Conclusion: We conclude that PL is a progressive disease involving multiple pelvic organs with high prevalence of intractable cystitis and hydronephrosis. The imaging characteristics can help predict diagnosis and, specifically appreciate progression.

  1. Determination of Mercury (II Ion on Aryl Amide-Type Podand-Modified Glassy Carbon Electrode

    Directory of Open Access Journals (Sweden)

    Sevgi Güney

    2011-01-01

    Full Text Available A new voltammetric sensor based on an aryl amide type podand, 1,8-bis(o-amidophenoxy-3,6-dioxaoctane, (AAP modified glassy carbon electrode, was described for the determination of trace level of mercury (II ion by cyclic voltammetry (CV and differential pulse voltammetry (DPV. A well-defined anodic peak corresponding to the oxidation of mercury on proposed electrode was obtained at 0.2 V versus Ag/AgCl reference electrode. The effect of experimental parameters on differential voltammetric peak currents was investigated in acetate buffer solution of pH 7.0 containing 1 × 10−1 mol L−1 NaCl. Mercury (II ion was preconcentrated at the modified electrode by forming complex with AAP under proper conditions and then reduced on the surface of the electrode. Interferences of Cu2+, Pb2+, Fe3+, Cd2+, and Zn2+ ions were also studied at two different concentration ratios with respect to mercury (II ions. The modified electrode was applied to the determination of mercury (II ions in seawater sample.

  2. Evaluation of sustained release suppositories prepared with fatty base including solid fats with high melting points.

    Science.gov (United States)

    Takatori, Toshihito; Shimono, Norihito; Higaki, Kazutaka; Kimura, Toshikiro

    2004-07-08

    To prepare the sustained release suppositories, solid fats such as polyglycerol ester of fatty acids (PGEFs) or beeswax were utilized with a fatty suppository base, Witepsol H15. PGEFs such as decaglycerol heptabehenate (HB750) and hexaglycerol pentastearate (PS500), and beeswax have relatively high melting points. The addition of PGEFs or beeswax to Witepsol H15 increased the apparent viscosity of suppository bases at 37 degrees C without any large change in the melting point of Witepsol H15. Moreover, the apparent viscosity of a mixed base with HB750, PS500 or beeswax at 37 degrees C was significantly correlated with the amount of each solid fat in a mixed base. The release of acetaminophen (AAP), a model drug, from suppositories was delayed by HB750, PS500 or beeswax, and an excellent correlation was observed between the apparent viscosity of these mixed bases and Higuchi's rate constants in each mixed base suppository, suggesting that these solid fats could regulate the drug release from the mixed base suppositories by changing their viscosity. In the in vivo absorption study in rats, several suppositories made from Witepsol H15-HB750 or Witepsol H15-beeswax mixed bases prolonged the rectal absorption of AAP without reducing AUC. In conclusion, by using solid fats such as HB750 and beeswax with relatively high melting points, it is possible to control the rate of drug release from fatty base suppositories for maintaining the plasma concentration of drugs for longer time periods.

  3. 毛细支气管炎的临床管理——美国儿科学会临床实践指南简介%Clinical management of bronchiolitis——clinical practice guidelines by American Academy of Pediatrics

    Institute of Scientific and Technical Information of China (English)

    范娟; 李茂军; 吴青; 陈昌辉

    2015-01-01

    毛细支气管炎是婴幼儿常见的一种病毒性下呼吸道感染.近年来,毛细支气管炎的发病率逐年增高,严重影响了儿童身体健康.为了更好地对婴幼儿毛细支气管炎进行管理,美国儿科学会(AAP)以循证医学为依据,对2006年10月发布的毛细支气管炎临床实践指南进行修订,为临床医师提供毛细支气管炎诊断、治疗和预防的新证据.%Bronchiolitis is a common lower respiratory tract viral infection in infants.Incidence of bronchiolitis is greatly increasing in recent years,and seriously affecting the health of children.In order to better manage bronchiolitis,American Academy of Pediatrics (AAP) convened a new subcommittee to review and revise the 2006 bronchiolitis guideline.This evidence-based guideline amended to provide new evidence of diagnosis,treatment and prevention bronchiolitis for the clinician.

  4. Assessing aphids potato virus Y-transmission efficiency: A new approach.

    Science.gov (United States)

    Boquel, Sébastien; Ameline, Arnaud; Giordanengo, Philippe

    2011-12-01

    In order to develop an alternative method to optimize the relative efficiency factor (REF) assessment, the efficiency of transmission of Potato virus Y (PVY) by seven aphid species was examined. In vitro micropropagated potato plantlets were used to experiment on phenotypically and genetically homogeneous material. Species-specific acquisition access period (AAP) on a PVY-infected plantlet was assessed for each aphid species using electrical penetration graph (EPG) technique. Aphid probing behaviour determined by EPG showed that Macrosiphum euphorbiae and Myzus persicae exhibited the shortest AAPs (15 and 11min, respectively) whereas Rhopalosiphum padi, Sitobion avenae, Brevicoryne brassicae and Acyrthosiphon pisum exhibited the longest ones (more than 30min). The transmission rate obtained for M. persicae (83.3%) was higher than the ones reported in the literature. REFs assessment showed that A. pisum and B. brassicae were poor efficient vectors while M. euphorbiae and S. avenae seemed to be efficient ones even though their respective REF were significantly lower than that of M. persicae. The species R. padi and A. fabae did not transmit PVY. The hypothesis assessed for M. euphorbiae and S. avenae and consisting in the compensation of a weak PVY-transmission efficiency by a higher number of vectors, was not supported. The use of this new method for REF evaluation and the need to consider aphid behaviour for such an assessment was discussed.

  5. A practicable approach for periodontal classification

    Directory of Open Access Journals (Sweden)

    Vishnu Mittal

    2013-01-01

    Full Text Available The Diagnosis and classification of periodontal diseases has remained a dilemma since long. Two distinct concepts have been used to define diseases: Essentialism and Nominalism. Essentialistic concept implies the real existence of disease whereas; nominalistic concept states that the names of diseases are the convenient way of stating concisely the endpoint of a diagnostic process. It generally advances from assessment of symptoms and signs toward knowledge of causation and gives a feasible option to name the disease for which etiology is either unknown or it is too complex to access in routine clinical practice. Various classifications have been proposed by the American Academy of Periodontology (AAP in 1986, 1989 and 1999. The AAP 1999 classification is among the most widely used classification. But this classification also has demerits which provide impediment for its use in day to day practice. Hence a classification and diagnostic system is required which can help the clinician to access the patient′s need and provide a suitable treatment which is in harmony with the diagnosis for that particular case. Here is an attempt to propose a practicable classification and diagnostic system of periodontal diseases for better treatment outcome.

  6. Inactivation of yeast alcohol dehydrogenase by alkylperoxyl radicals. Characteristics and influence of nicotinamide-adenine dinucleotides.

    Science.gov (United States)

    Videla, L A; Salim-Hanna, M; Lissi, E A

    1992-10-01

    The study of the interaction of alkylperoxyl radicals generated by the aerobic thermolysis of 2,2'-azobis(2-amidinopropane) (AAP) with yeast alcohol dehydrogenase (YADH) revealed a high reactivity of the enzyme, with an average of about 20 radicals per added YADH tetramer being needed to elicit its total inactivation. NAD+ enhanced YADH inactivation at NAD+/YADH molar ratios from 0.25 to 1, decreasing the rate of the process when added in excess to the enzyme concentration. At NADH/YADH molar ratios greater than 1, NADH exhibited a protective effect characterized by a poorly defined induction time and lower inactivation rates, which progressively increased during the reaction period. These changes occurred concomitantly with the oxidation of NADH into NAD+, which might counteract the protective effect of NADH. Under similar conditions, NADP+ did not modify AAP-induced YADH inactivation, while NADPH exhibited a modest protection at NADPH/YADH molar ratios greater than 1. It is concluded that YADH inactivation by alkylperoxyl radicals is strongly dependent on the redox state of the NADH-NAD+ couple, as the rates of the process at different time intervals inversely correlate with the respective NADH/NAD+ ratios.

  7. Enhanced stability of multilayer graphene-supported catalysts for polymer electrolyte membrane fuel cell cathodes

    Science.gov (United States)

    Marinkas, A.; Hempelmann, R.; Heinzel, A.; Peinecke, V.; Radev, I.; Natter, H.

    2015-11-01

    One of the biggest challenges in the field of polymer electrolyte membrane fuel cells (PEMFC) is to enhance the lifetime and the long-term stability of PEMFC electrodes, especially of cathodes, furthermore, to reduce their platinum loading, which could lead to a cost reduction for efficient PEMFCs. These demands could be achieved with a new catalyst support architecture consisting of a composite of carbon structures with significant different morphologies. A highly porous cathode catalyst support layer is prepared by addition of various carbon types (carbon black particles, multi-walled carbon nanotubes (MWCNT)) to multilayer graphene (MLG). The reported optimized cathodes shows extremely high durability and similar performance to commercial standard cathodes but with 89% lower Pt loading. The accelerated aging protocol (AAP) on the membrane electrode assemblies (MEA) shows that the presence of MLG increases drastically the durability and the Pt-extended electrochemical surface area (ECSA). In fact, after the AAP slightly enhanced performance can be observed for the MLG-containing cathodes instead of a performance loss, which is typical for the commercial carbon-based cathodes. Furthermore, the presence of MLG drastically decreases the ECSA loss rate. The MLG-containing cathodes show up to 6.8 times higher mass-normalized Pt-extended ECSA compared to the commercial standard systems.

  8. Farnesol induces cell detachment from established S. epidermidis biofilms.

    Science.gov (United States)

    Cerca, Nuno; Gomes, Fernanda; Bento, Joana C; França, Angela; Rolo, Joana; Miragaia, Maria; Teixeira, Pilar; Oliveira, Rosário

    2013-05-01

    Antibiotic resistance is a serious problem in Staphylococcus epidermidis infections as many clinical isolates of this organism are resistant to up to eight different antibiotics. The increased resistance to conventional antibiotic therapy has lead to the search for new antimicrobial therapeutic agents. Farnesol, an essential oil found in many plants, has been shown to be active against S. epidermidis. Using a type control strain we recently described that although farnesol was not efficient at killing biofilm bacteria, a strong reduction on biofilm biomass was detected, and we hypothesize that farnesol could, somehow, induce biofilm detachment. In this report, to test our hypothesis we used 36 representative clinical strains of S. epidermidis from different geographic locations and characterized them in terms of genetic variability by multilocus sequence typing and staphylococcal chromosome cassette mec. Strains were tested for biofilm formation, and the presence of ica, bhp and aap genes was determined. Stronger biofilms had always the presence of ica operon but often co-harbored bhp and aap genes. Farnesol was then used in biofilm-forming strains, and biofilm detachment was detected in half of the strains tested. Furthermore, we also showed that farnesol inability to kill biofilm bacteria was not the result of the biofilm structure but was related to high cell density. Our results demonstrate, for the first time, that the biomass reduction previously found by us, and many other groups, is the result not of cell killing but instead is the result of biofilm detachment.

  9. Herpesviruses and breast milk

    Directory of Open Access Journals (Sweden)

    C. Pietrasanta

    2014-06-01

    Full Text Available Breast milk has always been the best source of nourishment for newborns. However, breast milk can carry a risk of infection, as it can be contaminated with bacterial or viral pathogens. This paper reviews the risk of acquisition of varicella-zoster virus (VZV and cytomegalovirus (CMV, herpesviruses frequently detected in breastfeeding mothers, via breast milk, focusing on the clinical consequences of this transmission and the possible strategies for preventing it. Maternal VZV infections are conditions during which breastfeeding may be temporarily contraindicated, but expressed breast milk should always be given to the infant. CMV infection acquired through breast milk rarely causes disease in healthy term newborns; an increased risk of CMV disease has been documented in preterm infants. However, the American Academy of Pediatrics (AAP does not regard maternal CMV seropositivity as a contraindication to breastfeeding; according to the AAP, in newborns weighing less than 1500 g, the decision should be taken after weighing the benefits of breast milk against the risk of transmission of infection. The real efficacy of the different methods of inactivating CMV in breast milk should be compared in controlled clinical trials, rigorously examining the negative consequences that each of these methods can have on the immunological and nutritional properties of the milk itself, with a view to establish the best risk-benefit ratio of these strategies before they are recommended for use in clinical practice.

  10. Antioxidant activity in selected Slovenian organic and conventional crops

    Directory of Open Access Journals (Sweden)

    Manca KNAP

    2015-12-01

    Full Text Available The demand for organically produced food is increasing. There is widespread belief that organic food is substantially healthier and safer than conventional food. According to literature organic food is free of phytopharmaceutical residues, contain less nitrates and more antioxidants. The aim of the present study was to verify if there are any differences in the antioxidant activity between selected Slovenian organic and conventional crops. Method of DPPH (2,2-diphenyl-1-picryhydrazyl was used to determine the antioxidant activity of 16 samples from organic and conventional farms. The same varieties of crops were analysed. DPPH method was employed to measure the antioxidant activity of polar antioxidants (AAp and antioxidant activity of fraction in ethyl acetate soluble antioxidants (EA AA. Descriptive statistics and variance analysis were used to describe differences between farming systems. Estimated differences between interactions for the same crop and different farming practice were mostly not statistically significant except for the AAp for basil and beetroot. Higher statistically significant values were estimated for conventional crops. For the EA AA in broccoli, cucumber, rocket and cherry statistically significant higher values were estimated for organic production.

  11. Ask, advise, assist: pediatricians and passive smoke exposure.

    Science.gov (United States)

    Burnett, K F; Young, P C

    1999-06-01

    The objectives of this study were to determine: (1) how frequently pediatricians obtain a history of passive smoke exposure (PSE), (2) what type of advice regarding PSE they offer and how frequently they offer it, and (3) what methods and what assistance they believe would be useful to reduce PSE. A random sample of 1,000 US members (GEN) of the American Academy of Pediatrics (AAP) and all 724 members of the AAP sections of pulmonology, otolaryngology, and allergy (SPECS) were sent a questionnaire. Seven hundred fifty-five usable questionnaires were returned. Ninety-six percent of 321 general pediatricians obtained a PSE history at least "sometimes" but were much more likely to "always" do so when seeing a patient with asthma (87%) or recurrent otitis media (56%) than during well-child visits (41%) (p smoke around the child," or "quit smoking." Reasons for not initiating a cessation program included lack of skills (38%) or time (36%) or a belief that it was "not their responsibility" (13%). Pediatricians indicated that brochures for parents that describe the hazards of PSE and contain specific information regarding how to refer to community smoking cessation programs would be of most use to them in helping parents reduce PSE to their children. Pediatricians frequently ask about PSE and advise reducing it but seldom assist parents with specific advice regarding effective methods to quit smoking.

  12. [Percutaneous exclusion of traumatic abdominal aortic pseudoaneurysm from a brachial approach].

    Science.gov (United States)

    Gamboa, Ricardo; Ríos-Méndez, Raúl E; Solernó, Raúl; Giachello, Federico; Videla-Lynch, Ángeles; Sarmiento, Ricardo A

    2012-01-01

    Abdominal aortic pseudoaneurysm (AAP) is a rare lesion, although traumatic aortic injury is described as one of the main causes; both the rupture as the surgical treatment of the defect has high morbidity and mortality. Therefore, endovascular treatment either by chemical embolization or exclusion of defect with devices has emerged as an alternative treatment. However, there are risks such as occlusion of visceral vessels near the neck of the defect, embolization material or aortic rupture. Therefore, the choice of material and method of approach should be planned carefully in each case. We report a patient who ten years after abdominal wound firearm was diagnosed with AAP 17 x 13 cm, with short neck originated close to the ostium of the celiac trunk at an acute angle with the aortic axis. We perform the exclusion of the defect with a device designed for closing atrial septal defect from the left brachial access due to the angulation of the neck defect. There were no complications. At 72 hours was granted discharge. A month later, CT scan control showed the false aneurysm of equal size and no residual flow. The monitoring to date is five months and the patient remained asymptomatic.

  13. Modeling Multioperator Multi-UAV Operator Attention Allocation Problem Based on Maximizing the Global Reward

    Directory of Open Access Journals (Sweden)

    Yuhang Wu

    2016-01-01

    Full Text Available This paper focuses on the attention allocation problem (AAP in modeling multioperator multi-UAV (MOMU, with the operator model and task properties taken into consideration. The model of MOMU operator AAP based on maximizing the global reward is established and used to allocate tasks to all operators as well as set work time and rest time to each task simultaneously for operators. The proposed model is validated in Matlab simulation environment, using the immune algorithm and dynamic programming algorithm to evaluate the performance of the model in terms of the reward value with regard to the work time, rest time, and task allocation. The result shows that the total reward of the proposed model is larger than the one obtained from previously published methods using local maximization and the total reward of our method has an exponent-like relation with the task arrival rate. The proposed model can improve the operators’ task processing efficiency in the MOMU command and control scenarios.

  14. Biorelevant in vitro performance testing of orally administered dosage forms-workshop report.

    Science.gov (United States)

    Reppas, Christos; Friedel, Horst-Dieter; Barker, Amy R; Buhse, Lucinda F; Cecil, Todd L; Keitel, Susanne; Kraemer, Johannes; Morris, J Michael; Shah, Vinod P; Stickelmeyer, Mary P; Yomota, Chikako; Brown, Cynthia K

    2014-07-01

    Biorelevant in vitro performance testing of orally administered dosage forms has become an important tool for the assessment of drug product in vivo behavior. An in vitro performance test which mimics the intraluminal performance of an oral dosage form is termed biorelevant. Biorelevant tests have been utilized to decrease the number of in vivo studies required during the drug development process and to mitigate the risk related to in vivo bioequivalence studies. This report reviews the ability of current in vitro performance tests to predict in vivo performance and generate successful in vitro and in vivo correlations for oral dosage forms. It also summarizes efforts to improve the predictability of biorelevant tests. The report is based on the presentations at the 2013 workshop, Biorelevant In Vitro Performance Testing of Orally Administered Dosage Forms, in Washington, DC, sponsored by the FIP Dissolution/Drug Release Focus Group in partnership with the American Association of Pharmaceutical Scientists (AAPS) and a symposium at the AAPS 2012 Annual meeting on the same topic.

  15. A plasmonic colorimetric strategy for biosensing through enzyme guided growth of silver nanoparticles on gold nanostars.

    Science.gov (United States)

    Guo, Yuehua; Wu, Jie; Li, Jie; Ju, Huangxian

    2016-04-15

    A plasmonic colorimetric strategy was designed for sensitive detection of biomolecules through enzyme guided silver nanoparticles (AgNPs) growth on gold nanostars (AuNS). The growth of AgNPs on AuNS led to a substantial blue shift of the localized surface plasmon resonance (LSPR) peak and the color change of AuNS from blue to dark blue, purple and ultimately orange. Both the LSPR blueshift wavelength and the color of detection solution containing AuNS, Ag(+) and ascorbic acid 2-phosphate (AAP) depend on the amount of enzyme that catalyzed the dephosphorylation of AAP to reduce Ag(+) on AuNS surface. Thus this strategy could be used for LSPR and naked-eye detections of both the enzyme such as alkaline phosphatase (ALP) and other biomolecules involved in biorecognition events using ALP as a tag. The LSPR detection method for ALP showed a linear range from 1.0 pM to 25 nM with a detection limit of 0.5 pM. Using DNA as a mode target molecule, this technique showed a detection range from 10 fM to 50 pM DNA with a detection limit of 2.6 fM through the convenient combination with hybridization chain reaction amplification. The proposed plasmonic colorimetric strategy could be extended as a general analytical platform for design of immunosensors and aptasensors with ALP as a label.

  16. Novel routes to metalloorganics containing aluminum from minerals

    Science.gov (United States)

    Narayanan, Ramasubramanian

    Novel pathways for synthesizing Al metalloorganics directly from widely available oxides and oxo-hydroxides of aluminum are developed. The Al metalloorganics are then used to produce low-cost precursors for ceramics and polymers containing Al. Alumatrane, an unique, air-stable, aluminum alkoxide is prepared in one step from aluminum hydroxide in quantitative yields. Subsequently, alumatrane was used to prepare and characterize all group II dialuminate ceramics (MAlsb2Osb4, M = Mg, Ca, Sr, Ba). Similarly, an air-stable alkoxide of silicon was synthesized directly from SiOsb2, and is used in conjunction with alumatrane to produce precursors for aluminosilicate ceramics (MAlSiOsb4, M = K, Li, Na). Aluminum formate is synthesized, in differing efficiencies, from different crystalline minerals of Al, by direct dissolution in formic acid. A few other aluminum carboxylates are also synthesized, either directly from minerals or from aluminum formates, thus expanding the scope of the acid dissolution of aluminum hydroxides. Aluminum allyloxypropanoate (AAP) (Al(Osb2CCHsb2CHsb2OCH{=}CHsb2)sb2(OH)), an aluminum carboxylate with a polymerizable group has been synthesized from aluminum formate. This, has been incorporated into methyl methacrylate (MMA) polymers to impart fire retardancy. The increase in char yields as a result of AAP incorporation, indicate improved fire retardancy. Fire retardant characteristics of alumatrane has also been investigated, in MMA polymers and in a polyurethane polymer, taking char yields as a measure of fire retardance efficiency.

  17. A comparison of periodontal status in the two regional, population-based studies of SHIP and INVEST

    Science.gov (United States)

    Holtfreter, Birte; Demmer, Ryan T.; Bernhardt, Olaf; Papapanou, Panos N.; Schwahn, Christian; Kocher, Thomas; Desvarieux, Moise

    2012-01-01

    Objectives To compare the prevalence of periodontal disease between two randomly selected population-based studies (the Oral Infections and Vascular Disease Epidemiology Study (INVEST) and the Study of Health in Pomerania (SHIP)) and address relevant methodological issues. Methods Comparison was restricted to 55–81-years-olds. Attachment loss (AL), probing depth (PD), and tooth count were assessed in INVEST (full-mouth, six sites) and SHIP (half-mouth, four sites). Subjects were classified according to the CDC/AAP case definition. Recording protocols were standardized. Mixed linear or logistic models were used to compare INVEST with SHIP. Results Mean half-mouth AL was lower in INVEST vs. SHIP (INVEST: 2.9mm versus SHIP: 4.0mm, p<0.05). Findings were similar across multiple periodontal disease definitions. After equalisation of recording protocols and adjustment for periodontal risk factors, mean AL and PD were 1.2mm and 0.3mm lower in INVEST vs. SHIP (p<0.001). The odds for severe periodontitis (CDC/AAP) was 0.2-fold in INVEST vs. SHIP (p<0.001). Confounding effects of age, gender, race/ethnicity, education, and use of interdental care devices were highest as indicated by change-in-estimate for study. Conclusion Implementation of the proposed method for comparison of epidemiological studies revealed that periodontitis was less prevalent in INVEST compared to SHIP, even after extensive risk-factor adjustment. PMID:23061920

  18. 急诊科醉酒患者血清hs-CRP水平、NLR及EPIC评分对急性胰腺炎的诊断价值%The Value of Serum Hs-CRP Level NLR and EPIC Score for the Diagnosis of Acute Pancreatitis in Alcoholism Patients in Emergency Department

    Institute of Scientific and Technical Information of China (English)

    王书强; 张晓兰

    2015-01-01

    Objective To study the value of serum hs-CRP level NLR and EPIC score for the diagnosis of acute pancreatitis in alcoholism patients with emergency department. Method 100 cases of alcoholism patients in our hospital from January 2013-December 2014 were selected, including 38 patients with AAP as observation group, 62 cases of patients without the AAP as control group, all patients received blood tests and abdominal CT examination within 24h admitted to hospital, compared the serum hs-CRP levels, NLR and EPIC scale of the two groups of patients, analysis the relationship between three indicators and AAP illness severity. Results The proportion of male patients, proportion of SAP patients, the serum hs-CRP levels, NLR and EPIC score of the observing group were higher than the control group, the age of the observation group was younger than those in control group, the difference has statistical signiifcance (all P<0.05). Conclusion AAP occurs in young and middle-aged men, its has high incidence of SAP, its serum hs-CRP levels, NLR and EPIC score was higher than the non-AAP patients;the serum hs-CRP levels, NLR and EPIC scale can be used as the effective index response the severity of the alcoholism patients.%目的:探讨急诊科醉酒患者血清hs-CRP水平、NLR(中性粒细胞与淋巴细胞比值)及EPIC(胰腺外炎症CT评分)对急性胰腺炎(AAP)的诊断价值及与病情严重程度的关系。方法选取2013年1月至2014年12月我院收治的醉酒患者100例,其中AAP患者38例作为观察组,非AAP患者62例作为对照组,所有患者入院24 h内进行血液检验及腹部CT检查,对比两组患者的血清hs-CRP水平、NLR及EPIC评分,分析三项指标与AAP病情严重性的关系。结果观察组男性患者比例、血清hs-CRP水平、NLR及EPIC评分较对照组高,观察组患者年龄较对照组轻,差异具有统计学意义(均P<0.05)。结论醉酒患者中,AAP好发于中青年男性,其重

  19. Diarrheagenic Escherichia coli carrying supplementary virulence genes are an important cause of moderate to severe diarrhoeal disease in Mexico.

    Directory of Open Access Journals (Sweden)

    Sandra Patzi-Vargas

    2015-03-01

    Full Text Available Diarrheagenic Escherichia coli (DEC cause acute and persistent diarrhoea worldwide, but little is known about their epidemiology in Mexico. We determined the prevalence of bacterial enteropathogens in 831 children with acute diarrhoea over a four-year period in Yucatan, Mexico. Six DEC supplementary virulence genes (SVG, mainly associated with enteroaggregative E. coli (EAEC, were sought in 3100 E. coli isolates. DEC was the most common bacterial enteropathogen (28%, surpassing Salmonella (12% and Shigella (9%. Predominant DEC groups were diffusely adherent E. coli (DAEC (35%, EAEC (24%, and enteropathogenic E. coli (EPEC (19%. Among children with DEC infections, 14% had severe illness mainly caused by EPEC (26% and DAEC (18%; 30% had moderate diarrhoea mainly caused by DAEC (36%, mixed DEC infections (33% and EAEC (32%. DAEC was most prevalent during spring, while ETEC, EAEC and EPEC predominated in summer. EAEC was more frequent in children 6-24 months old than in those younger than 6 months of age (P = 0.008, OR = 4.2, 95% CI, 1.3-13.9. The presence of SVG dispersin, (aatA, dispersin-translocator (aatA, enteroaggregative heat-stable toxin 1 (astA, plasmid encoded toxin (pet, cytolethal distending toxin (cdt was higher in DEC than non-DEC strains, (36% vs 26%, P <0.0001, OR = 1.5, 95% CI, 1.3-1.8. 98% of EAEC-infected children harboured strains with SVG; 85% carried the aap-aatA gene combination, and 33% of these also carried astA. 28% of both EPEC and ETEC, and 6% of DAEC patients had strains with SVG. 54% of EPEC patients carried pet-positive strains alone or in combination with astA; only this DEC group harboured cdt-positive isolates. All ETEC patients carried astA- or astA-aap-positive strains. astA and aap were the most common SVG in DAEC (3% and 2% and non-DEC strains (21% and 13%. DEC carrying SVG are an important cause of moderate to severe bacterial diarrhoea in Mexican children.

  20. Direct evidence of phosphorus outbreak release from sediment to overlying water in a large shallow lake caused by strong wind wave disturbance

    Institute of Scientific and Technical Information of China (English)

    ZHU Guangwei; QIN Boqiang; GAO Guang

    2005-01-01

    Concentration variations of suspended solids (SS), total phosphorus (TP), dissolved total phosphorus (DTP), dissolved reactive phosphorus (SRP), and algae available phosphorus (AAP) in overlying water were observed during the coldest week in a year in Lake Taihu, a large shallow lake in China. Water samples at different water depths were collected with wind speeds of 8, 12, 0 and 0 m/s on 23, 24, 26 and 30 January 2004, respectively. On 23 January 2004, SS concentration increased to 258 mg/L with a wind speed of 8 m/s lasting for 1 h. SS concentration kept increasing and reached to 507 mg/L when the strong wind lasted for 24 h and the peak value of wind-speed reached to 12 m/s on 24 January 2004. On 26 January 2004, SS concentration decreased to 51 mg/L with the wind speed smaller than 2 m/s lasting for about half a day. Then after five continuous waveless days, SS concentration decreased to 21 mg/L on 30 January 2004. The observed results confirmed that sediments in Lake Taihu would be intensively suspended if the surface wind speed is greater than 8 m/s, and the magnitude of SS would increase with increasing wind-speed. Coupled with the intensive sediment suspending, concentrations of TP, DTP and SRP on 23 January were 0.210, 0.048 and 0.035 mg/L, respectively. And they were 0.299, 0.054 and 0.026 mg/L on 24 January, which were significantly higher than those on 26 and 30 January. SRP concentration on 23 January was twice as high as that observed on 30 January. It indicates that the strong wind may result in an outbreak release of phosphorus. Moreover, AAP contents in suspended solids were 132, 97 and 226 mg/kg on 23, 24 and 26 January, respectively. Therefore, it could be estimated that this strong wind process resulted in 987 t of TP, 80 t of SRP and 167 t of AAP releasing from sediments into overlying water. Since such strong wind process is frequent in the area of Lake Taihu, dynamical release driven by wind-induced wave disturbance may be the main mode for