Characteristic of retained austenite decomposition during tempering and its effect on impact toughness in SA508 Gr.3 steel

Energy Technology Data Exchange (ETDEWEB)

Yan, Guanghua; Han, Lizhan; Li, Chuanwei; Luo, Xiaomeng; Gu, Jianfeng, E-mail: gujf@sjtu.edu.cn

2017-01-15

Retained austenite(RA) usually presents in the quenched Nuclear Pressure-Vessel SA508 Gr.3 steel. In the present work, the characteristic of RA decomposition and its effect on the impact toughness were investigated by microstructure observation, dilatometric experiments and Charpy impact tests. The results show that the RA transformed into martensite and bainite during tempering at 230 °C and 400 °C respectively, while mixture of long rod carbides and ferrite formed at 650 °C. The long rod carbides formed from RA decomposition decrease the critical cleavage stress for initiation of micro-cracks, and deteriorate the impact toughness of the steel. Pre-tempering at a low temperature such as 230 °C or 400 °C leading to the decomposition of RA into martensite or baintie can eliminate the deterioration of the toughness caused by direct decomposition into long rod carbides. The absorbed energy indicate that pre-tempering at 400 °C can drive dramatically improvement in the toughness of the steel. - Highlights: • The products of RA decomposition were localization observed by SEM and TEM. • Decomposition characteristic of RA were revealed during tempering at different temperature. • Impact toughness was dramatically improved by pre-tempering treatment.

Competencia de argumentación en la interpretación de gráficas funcionales

OpenAIRE

Solar Bezmalinovic, Horacio; Azcárate Giménez, Carmen; Deulofeu Piquet, Jordi

2012-01-01

En este artículo se interpreta la argumentación en la interpretación de gráficas funcionales, como una competencia matemática. Esta competencia se ha caracterizado mediante tareas matemáticas asociadas a la interpretación de dichas gráficas y por determinados procesos. Éstos procesos se repiten y se desarrollan a largo plazo en el currículum de matemáticas mientras que las tareas cambian y su alcance es a corto plazo. Las relaciones entre tareas y procesos permiten identificar el progreso de ...

Detección de actividad pectolítica en el cultivo de la cepa GR4 de rhyzobíum meliloti

Directory of Open Access Journals (Sweden)

P. Martínez M.

2010-07-01

Full Text Available Se ensayaron varios métodos para la obtención y purificación parcial de pectinasas a partir de sobrenadante del cultivo de la cepa GR4 de Rhizobium meliloti. Se describe el método con el cual se obtuvo el sobrenadante en el que se logró detectar la presencia de actividad pectolítica. Empleando una muestra comercial de enzimas pécticas (Pectinex, Novo se estudió la estabilidad de la actividad enzimática durante el proceso de purificación parcial establecido; se observó una pérdida gradual de la actividad en función del tiempo de duración del proceso.

24 CFR 965.508 - Individual relief.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Individual relief. 965.508 Section 965.508 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... PHA-OWNED OR LEASED PROJECTS-GENERAL PROVISIONS Resident Allowances for Utilities § 965.508 Individual...

Gráfica urbana como comunicación visual preventiva

Directory of Open Access Journals (Sweden)

D.G. Natalia Vanesa Morales Suvires

2010-11-01

Full Text Available Este trabajo se plantea desde el enfoque del Diseño Gráfico con el fin de contribuir de manera significativa al incremento de la concientización respecto de la amenaza sísmica existente en la provincia de San Juan. Metodológicamente el proyecto se desglosó en tres etapas: 1 relevamiento de la gráfica comunicacional existente; 2 análisis y evaluación; y 3 formulación de pautas de prevención y mitigación de los efectos del riesgo sísmico. De este modo se han definido pautas de comunicación visual que responden a los aspectos de identidad cultural de la zona, las necesidades puntuales de la población, los recursos locales, y la posible aceptación de la comunidad, todo dentro del marco de la prevención sísmica.

Comparative study of main dosimetric characteristics between the GR-200A and MCP-N LiF (Mg, Cu, P) TLD chips

International Nuclear Information System (INIS)

Shen Wenxiu; Tang Kaiyong; Wang Shoushan; Cai Gangang; Zhu Hongying; Lu Min

1999-01-01

GR-200A and MCP-N are the same kind of LiF(Mg, Cu, P) chip detectors. The main dosimetric characteristics of two LiF (Mg, Cu, P) chip TLDs (GR-200A made in Solid Dosimetric Detector and Method Laboratory, Beijing, and MCP-N made in Poland) are compared, including glow curve structure, TL sensitivity, anti-moisture, reproducibility, background, detection threshold and photosensitivity. Sensitivity of GR-200a is 1.6 times as much as that of MCP-N. The sensitivity of GR-200A is stable after being used for six times, but the sensitivity of MCP-N dropped 2.8%, and its colour turned from white into light brown. The sensitivity and colour of GR-200A did not vary after being stored for 25 days at 98% RH, by comparison the sensitivity of MCP-N dropped 14%, and its colour turned into light brown. It was found that the GR-200A TLD is superior to the MCP-N TLD in above-mentioned characteristics

F508del-CFTR rescue: a matter of cell stress response.

Science.gov (United States)

Nieddu, Erika; Pollarolo, Benedetta; Merello, Luisa; Schenone, Silvia; Mazzei, Mauro

2013-01-01

Cystic fibrosis (CF) is a common inherited fatal disease affecting 70,000 people worldwide, with a median predicted age of survival of approximately 38 years. The deletion of Phenylalanine in position 508 of the Cystic Fibrosis Transmembrane conductance Regulator (F508del-CFTR) is the most common mutation in CF patients: the deleted protein, not properly folded, is degraded. To date no commercial drugs are available. Low temperature, some osmolytes and conditions able to induce heat shock protein 70 (Hsp70) expression and heat shock cognate 70 (Hsc70) inhibition result in F508del-CFTR rescue, hence restoring its physiological function: this review sheds light on the correlation between these several evidences. Interestingly, all these approaches have a role in the cell stress response (CSR), a set of cell reactions to stress. In addition, unpredictably, F508del-CFTR rescue has to be considered in the frame of CSR: entities that induce - or are induced during - the CSR are, in general, also able to correct trafficking defect of CFTR. Specifically, the low temperature induces, by definition, a CSR; osmolytes, such as glycerol and trimethylamine N-oxide (TMAO), are products of the CSR; pharmacological correctors, such as Matrine and 4-phenylbutirric acid (4PBA), down-regulate the constitutive Hsc70 in favor of an up-regulation of the inducible chaperone Hsp70, another component of the CSR. The identification of a common mechanism of action for different types of correctors could drive the discovery of new active molecules in CF, overcoming methods clinically inapplicable, such as the low temperature.

La comunicación técnica entre el diseño gráfico y la producción Estudio sobre el estado de la comunicación técnica en el Sector Gráfico Español.

OpenAIRE

Puértolas, Rafael Pozo

2012-01-01

Como inicio de este trabajo deseo manifestar que he seleccionado para esta investigación el tema de la comunicación técnica, influenciado por mis inquietudes como diseñador gráfico, mi profesión en las artes gráficas y mi vinculación a la docencia universitaria en el diseño. Actualmente a nivel profesional soy socio fundador y editor de la editorial Ediciones CPG Productos Editoriales, s.l. con sede en Barcelona - España. A nivel universitario soy profesor de grado en diseño gr...

Attenuated bioluminescent Brucella melitensis mutants GR019 (virB4), GR024 (galE), and GR026 (BMEI1090-BMEI1091) confer protection in mice.

Science.gov (United States)

Rajashekara, Gireesh; Glover, David A; Banai, Menachem; O'Callaghan, David; Splitter, Gary A

2006-05-01

In vivo bioluminescence imaging is a persuasive approach to investigate a number of issues in microbial pathogenesis. Previously, we have applied bioluminescence imaging to gain greater insight into Brucella melitensis pathogenesis. Endowing Brucella with bioluminescence allowed direct visualization of bacterial dissemination, pattern of tissue localization, and the contribution of Brucella genes to virulence. In this report, we describe the pathogenicity of three attenuated bioluminescent B. melitensis mutants, GR019 (virB4), GR024 (galE), and GR026 (BMEI1090-BMEI1091), and the dynamics of bioluminescent virulent bacterial infection following vaccination with these mutants. The virB4, galE, and BMEI1090-BMEI1091 mutants were attenuated in interferon regulatory factor 1-deficient (IRF-1(-/-)) mice; however, only the GR019 (virB4) mutant was attenuated in cultured macrophages. Therefore, in vivo imaging provides a comprehensive approach to identify virulence genes that are relevant to in vivo pathogenesis. Our results provide greater insights into the role of galE in virulence and also suggest that BMEI1090 and downstream genes constitute a novel set of genes involved in Brucella virulence. Survival of the vaccine strain in the host for a critical period is important for effective Brucella vaccines. The galE mutant induced no changes in liver and spleen but localized chronically in the tail and protected IRF-1(-/-) and wild-type mice from virulent challenge, implying that this mutant may serve as a potential vaccine candidate in future studies and that the direct visualization of Brucella may provide insight into selection of improved vaccine candidates.

Arte gráfico y tecnología una relación privada en la obra (gráfica) de Fabiola Ubani

OpenAIRE

Ubani García, Fabiola

2015-01-01

Programa de doctorado: En torno al problema de la génesis y el modelo en Arte y Arquitectura. Bienio 96/98 [ES]La tesis doctoral, Arte Gráfico y Tecnología una Relación Privada en la Obra (Gráfica) de Fabiola Ubani parte del análisis de la obra realizada por la Doctoranda a lo largo de veinticinco años de trayectoria artística. Obra en la que la tecnología ha jugado un papel fundamental, tanto en el proceso como en el producto. Por lo que el principal objetivo se orienta en: analizar y pro...

Low cycle fatigue behaviors of low alloy steels in 310 .deg. C deoxygenated water

International Nuclear Information System (INIS)

Jang, Hun

2008-02-01

After low cycle fatigue tests of SA508 Gr.1a low alloy steel in 310 .deg. C deoxygenated water, the fatigue surface and the sectioned area of specimens were observed to understand the effect of the cyclic strain rate on the environmentally assisted cracking behaviors. From the fatigue crack morphologies of the specimen tested at a strain rate of 0.008 %/s, unclear ductile striations and blunt crack tip were observed. So, metal dissolution could be the main cracking mechanism of the material at the strain rate. On the other hand, on the fatigue surface of the specimen tested at strain rates of 0.04 and 0.4 %/s, the brittle cracks and the flat facets, which are the evidence of the hydrogen induced cracking, were observed. Also, the tendency of linkage between the main crack and micro-cracks was observed on the sectioned area. Therefore, the main cracking mechanism at the strain rates of 0.04 and 0.4 %/s could be the hydrogen induced cracking. Additionally, the evidence of the dissolved MnS inclusions was observed on the fatigue surface from energy dispersive x-ray spectrometer analyses. So, despite of the low sulfur content of the test material, the sulfides seem to contribute to environmentally assisted cracking of SA508 Gr.1a low alloy steel in 310 .deg. C deoxygenated water. Additionally, our experimental fatigue life data of SA508 Gr.1a low alloy steel (heat A) showed a consistent difference with statistical model produced in argon national laboratory. So, additional low cycle fatigue tests of other heat SA508 Gr.1a (heat B) and SA508 Gr.3 low alloy steels were performed to investigate the effect of material variability on fatigue behaviors of low alloy steels in 310 .deg. C deoxygenated water. In results, the fatigue lives of three low alloy steels were increased following order: SA508 Gr.1a low alloy steel - heat A, SA508 Gr.3 low alloy steel, and SA508 Gr.1a low alloy steel - heat B. From microstructure observation, the fatigue surface of SA508 Gr.1a low alloy

Análise comparativa das PE e PI máximas entre mulheres grávidas e não-grávidas e entre grávidas de diferentes períodos gestacionais

Directory of Open Access Journals (Sweden)

Leila Graziele Dias de Almeida

2005-10-01

Full Text Available O propósito deste estudo foi de verificar as possíveis diferenças entre as pressões inspiratórias e expiratórias máxima de mulheres grávidas e não-grávidas, bem como entre grávidas de períodos gestacionais diferentes. Para obtenção das informações propostas, foi utilizado o aparelho manuvacuômetro MVD 500, Mhmicrohard Global Med, como instrumento aferidor das pressões expiratória e inspiratória máxima de gestantes e não-gestantes compreendidas dentro de um mesmo grupo etário. O critério utilizado para seleção de informantes desta pesquisa foi estar grávida para um dos grupos e não estar grávida para o outro, sendo as mesmas escolhidas aleatoriamente através de indicações de informantes. A abordagem das informantes foi realizada em suas residências onde foram coletados dados de pressão inspiratória e expiratória máximas para posteriormente serem organizados, processados, categorizados e finalmente obter-se as médias encontradas nos grupos da amostra da pesquisa. As médias de pressão inspiratória e expiratória máximas obtidas nos grupos das gestantes foram as seguintes: PEmax.= 51,3cm H20; e Pimax= 48,3 cm H20; já as médias encontradas no grupo das não-gestantes foram: PEmax = 73 cm H2O, Pimax= 69,2cm H2O. As gestantes pertencentes ao subgrupo do primeiro ao quinto mês apresentaram uma média de PE= 56 cm H2O, e de PI= 60 cm H2O, enquanto que as gestantes do subgrupo a partir do sexto mês apresentaram as médias de PE e Pi= 56 cm H2O e 43,2 cm H2O respectivamente. Os resultados obtidos forneceram subsídios para inferir que existem diferenças entre as pressões inspiratória e expiratória máximas entre grávidas e não-grávidas, bem como em grávidas de período gestacionais diferentes

La normalización entre el proceso de diseño y la producción gráfica

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Rafael Pozo Puértolas

2015-07-01

Full Text Available Esta reseña aporta una breve síntesis de la evolución del Proyecto de Normalización Español realizado en AENOR, a través del comité AEN/CTN 54 Industrias gráficas, que estudia los mecanismos de comunicación técnica entre el proceso de diseño y la producción gráfica. Y presenta las nuevas Normas UNE 54117:2014 y la serie UNE 54131:2014.

Tumor cell-released TLR4 ligands stimulate Gr-1+CD11b+F4/80+ cells to induce apoptosis of activated T cells.

Science.gov (United States)

Liu, Yan-Yan; Sun, Ling-Cong; Wei, Jing-Jing; Li, Dong; Yuan, Ye; Yan, Bin; Liang, Zhi-Hui; Zhu, Hui-Fen; Xu, Yong; Li, Bo; Song, Chuan-Wang; Liao, Sheng-Jun; Lei, Zhang; Zhang, Gui-Mei; Feng, Zuo-Hua

2010-09-01

Gr-1(+)CD11b(+)F4/80(+) cells play important roles in tumor development and have a negative effect on tumor immunotherapy. So far, the mechanisms underlying the regulation of their immunosuppressive phenotype by classical and alternative macrophage activation stimuli are not well elucidated. In this study, we found that molecules from necrotic tumor cells (NTC-Ms) stimulated Gr-1(+)CD11b(+)F4/80(+) cells to induce apoptosis of activated T cells but not nonstimulated T cells. The apoptosis-inducing capacity was determined by higher expression levels of arginase I and IL-10 relative to those of NO synthase 2 and IL-12 in Gr-1(+)CD11b(+)F4/80(+) cells, which were induced by NTC-Ms through TLR4 signaling. The apoptosis-inducing capacity of NTC-Ms-stimulated Gr-1(+)CD11b(+)F4/80(+) cells could be enhanced by IL-10. IFN-gamma may reduce the apoptosis-inducing capacity of Gr-1(+)CD11b(+)F4/80(+) cells only if their response to IFN-gamma was not attenuated. However, the potential of Gr-1(+)CD11b(+)F4/80(+) cells to express IL-12 in response to IFN-gamma could be attenuated by tumor, partially due to the existence of active STAT3 in Gr-1(+)CD11b(+)F4/80(+) cells and NTC-Ms from tumor. In this situation, IFN-gamma could not effectively reduce the apoptosis-inducing capacity of Gr-1(+)CD11b(+)F4/80(+) cells. Tumor immunotherapy with 4-1BBL/soluble programmed death-1 may significantly reduce, but not abolish the apoptosis-inducing capacity of Gr-1(+)CD11b(+)F4/80(+) cells in local microenvironment. Blockade of TLR4 signaling could further reduce the apoptosis-inducing capacity of Gr-1(+)CD11b(+)F4/80(+) cells and enhance the suppressive effect of 4-1BBL/soluble form of programmed death-1 on tumor growth. These findings indicate the relationship of distinct signaling pathways with apoptosis-inducing capacity of Gr-1(+)CD11b(+)F4/80(+) cells and emphasize the importance of blocking TLR4 signaling to prevent the induction of T cell apoptosis by Gr-1(+)CD11b(+)F4/80(+) cells.

Humor gráfico y comprensión de deseos

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Mónica Roncancio Moreno

2012-01-01

Full Text Available El presente artículo tiene como propósito documentar la comprensión de los deseos a partir de dos aproximaciones: situaciones que utilizan el humor gráfico y situaciones clásicas de preferencias con niños entre 2.8 y 3 años. Se trabaja con el método microgenético combinado con un estudio en series de tiempo durante 10 sesiones de aplicación (dos meses y medio. Se realizan dos tipos de análisis, uno intragrupo y uno intraindividual que permite capturar los diversos caminos por los cuales transitan los niños al enfrentarse a las tareas. Los resultados arrojan la identificación de tres tendencias en los desempeños: estable, descendente y ascendente. Igualmente, se pone en evidencia la importancia de trabajar otras vías para el estudio de los procesos cognitivos en términos metodológicos y se confirma el humor gráfico como alternativa para el estudio de los estados mentales.

La representación gráfica de la información en el nuevo diseño de periódicos

OpenAIRE

López Alonso, Rodrigo

2011-01-01

El objeto de estudio de esta investigación es el conjunto de elementos gráficos que intervienen en el diseño de la visualización de información en los periódicos diarios españoles. Estos gráficos informativos o infografías forman parte a su vez del diseño general del periódico, de sus elementos visuales –tipográficos e iconográficos- y estructurales que dan forma al periódico. En este sentido pretendemos estudiar estos gráficos en el contexto de la renovación formal y los rediseños...

Interfaz Gráfica Computacional para Destilación Multicomponente utilizando Métodos Cortos

OpenAIRE

A. Osorio Mirón; Gloria Dominguez Hernández

2011-01-01

En este trabajo, se elaboró una interfaz gráfica que determina por medio de simulación en estado estacionario el número de platos necesarios en el proceso de destilación multicomponente, así como la composición en el flujo de destilado y fondos de una torre de destilación utilizando métodos cortos. La interfaz gráfica de usuario, se construyó en el lenguaje de programación Python 2.5, permite presentar los datos de entrada y salida para el caso de columnas de destilación operando en régimen p...

Interfaz gráfica de usuario para configuración y supervisión de sistemas robóticos aéreo

OpenAIRE

Pascual y Mora, Jorge Luis

2018-01-01

Este proyecto se centra en el análisis exhaustivo del interfaz gráfico de usuario perteneciente al proyecto Aerostack y su rediseño, tanto a nivel visual para mejorar la estética y usabilidad como a nivel de estructura de código para mejorar su calidad y aumentar la modularidad y escalabilidad del software. En este documento se tratan, en concreto, el análisis tanto de código como de diseño gráfico, diseño de los cambios propuestos, implementación y validación sobre los disti...

La mirada interactiva. De la gráfica de la interacción impresa a la edición de contenidos

Directory of Open Access Journals (Sweden)

Eugenio Vega Pindado

2014-01-01

Full Text Available Los medios digitales han sustituido progresivamente al papel como soporte de comunicación. Han hecho necesaria la existencia de dispositivos mecánicos para la lectura del los documentos que antes eran directamente manipulados por el lector. En el papel la disposición gráfica de textos e imágenes dependía de cada libro. La elección del tamaño, del formato y del color se hacía en función de la estructura de la obra. Sin embargo, en la era digital, la disposición gráfica depende del dispositivo que pone a disposición del lector los documentos. A pesar de sus ventajas evidentes para reordenar la información, han incorporado procedimientos interactivos de los medios impresos que guardaban relación con la habilidad del lector para mirar, leer y comprender la composición. Este trabajo analiza la pervivencia de los modelos gráficos de la interacción impresa en estos nuevos soportes.Digital media has gradually replaced paper as a medium of communication. These new media have need the existence of mechanical devices for reading documents that until now were directly manipulated by the reader. In printed paper graphical layout of text and images depended on each book. The choice of size, color and proportion was a consequence of the structure of the work. However, in digital age, graphic layout depends on the device that makes available documents to the reader. Despite its obvious advantages to reorder the information, have incorporated interactive procedures from print media that were relevant to the reader's ability to see, read and understand the whole layout. This paper analyzes the survival of graphical interaction models in these new media

Grøn Open Access i Praksis

DEFF Research Database (Denmark)

Open Access indikatoren påviste et uudnyttet potentiale på ca 60%, men hvorfor er der så ikke mere Open Access indhold?. I det konkrete arbejde med forskningsregistrering og registrering af post-prints støder bibliotekerne på en række udfordringer, som vanskeliggør institutionernes muligheder...... for at nå de nationale Open Access mål. Det er for eksempel inden for områderne rettigheder og licenser, tilladte Open Access versioner, embargoperioder m.m., at vi støder på problemer. Det er disse meget konkrete udfordringer, der arbejdes med i det kommende DEFF projekt ”Grøn Open Access i praksis”....

A New Flame-Retardant Polyamide Containing Phosphine Oxide and N,N-(4,4-diphenylether) Moieties in the Main Chain: Synthesis and Characterization

OpenAIRE

FAGHIHI, Khalil

2014-01-01

A new flame-retardant polyamide containing phosphine oxide moieties in the main chain was synthesized from the solution polycondensation reaction of bis(3-aminophenyl) phenyl phosphine oxide with N,N-(4,4-diphenylether) bis trimellitimide, using thionyl chloride, N-methyl-2-pyrolidone, and pyridine as condensing agents. This new polymer was obtained in high yield (92%), has high inherent viscosity (0.73 dL/g), and was characterized by elemental analysis, FT-IR spectroscopy, thermal gr...

Estudio de la accesibilidad de las interfaces gráficas en la televisión de alta definición

OpenAIRE

Alonso Vara, Adrian; Martín Edo, Carlos Alberto; Menendez Garcia, Jose Manuel; Cisneros Perez, Guillermo

2010-01-01

La televisión digital permite un incremento del número de servicios difundidos. Esto puede derivar en que la gestión de los mismos se dificulte de manera notable para el usuario con discapacidad. Así mismo, la televisión digital se caracteriza por la proliferación de interfaces gráficas, por ejemplo, menús de configuración, guías de programas y miniguías, aplicaciones interactivas... Las interfaces gráficas de usuario suponen una de las barreras más importantes que las personas ciegas y con d...

Traducción del lenguaje cotidiano al gráfico: una experiencia de fábula

Directory of Open Access Journals (Sweden)

José Luis Córdova-Frunz

2013-01-01

Full Text Available La resolución de problemas implica traducir lenguajes, por lo que frecuentemente se analizan los problemas sobre la traducción del lenguaje cotidiano al algebraico. Se ha investigado poco acerca de la traducción entre los lenguajes cotidiano y gráfico, siendo que esta traducción obliga al uso de habilidades superiores de pensamiento: selección de información, de variables relevantes, de escalas, etc. Presentamos un estudio exploratorio en este tema, de las habilidades de estudiantes universitarios de reciente ingreso con el fin de evaluar el nivel de desarrollo de estas destrezas. Hacemos uso de un ejercicio no estructurado en el que los alumnos deben graficar la información que brinda un texto. Se empleó una lista de cotejo para el análisis de resultados; éstos muestran que los alumnos tienen poca habilidad para la traducción del español al lenguaje gráfico y tienden a confundir una gráfica con una trayectoria.

Calculadoras gráficas y precálculo. Programa de investigación

OpenAIRE

Gómez, Pedro

1994-01-01

La siguiente es una propuesta para la presentación de los resultados del proyecto de investigación "Calculadoras gráficas y precálculo" en el marco del II Congreso Iberoamericano de Educación Matemática.

Impaired spermatogenesis and gr/gr deletions related to Y chromosome haplogroups in Korean men.

Directory of Open Access Journals (Sweden)

Jin Choi

Full Text Available Microdeletion of the Azoospermia Factor (AZF regions in Y chromosome is a well-known genetic cause of male infertility resulting from spermatogenetic impairment. However, the partial deletions of AZFc region related to spermatogenetic impairment are controversial. In this study, we characterized partial deletion of AZFc region in Korean patients with spermatogenetic impairment and assessed whether the DAZ and CDY1 contributes to the phenotype in patients with gr/gr deletions. Total of 377 patients with azoo-/oligozoospermia and 217 controls were analyzed using multiplex polymerase chain reaction (PCR, analysis of DAZ-CDY1 sequence family variants (SFVs, and quantitative fluorescent (QF-PCR. Of the 377 men with impaired spermatogenesis, 59 cases (15.6% had partial AZFc deletions, including 32 gr/gr (8.5%, 22 b2/b3 (5.8%, four b1/b3 (1.1% and one b3/b4 (0.3% deletion. In comparison, 14 of 217 normozoospermic controls (6.5% had partial AZFc deletions, including five gr/gr (2.3% and nine b2/b3 (4.1% deletions. The frequency of gr/gr deletions was significantly higher in the azoo-/oligozoospermic group than in the normozoospermic control group (p = 0.003; OR = 3.933; 95% CI = 1.509-10.250. Concerning Y haplogroup, we observed no significant differences in the frequency of gr/gr deletions between the case and the control groups in the YAP+ lineages, while gr/gr deletion were significantly higher in azoo-/oligozoospermia than normozoospermia in the YAP- lineage (p = 0.004; OR = 6.341; 95% CI = 1.472-27.312. Our data suggested that gr/gr deletion is associated with impaired spermatogenesis in Koreans with YAP- lineage, regardless of the gr/gr subtypes.

Interfaz Gráfica Computacional para Destilación Multicomponente utilizando Métodos Cortos

Directory of Open Access Journals (Sweden)

A. Osorio Mirón

2011-12-01

Full Text Available En este trabajo, se elaboró una interfaz gráfica que determina por medio de simulación en estado estacionario el número de platos necesarios en el proceso de destilación multicomponente, así como la composición en el flujo de destilado y fondos de una torre de destilación utilizando métodos cortos. La interfaz gráfica de usuario, se construyó en el lenguaje de programación Python 2.5, permite presentar los datos de entrada y salida para el caso de columnas de destilación operando en régimen permanente. Los resultados del uso de la interfaz gráfica muestran una forma simple de realizar diseños preliminares de torres de destilación y su potencialidad como material de apoyo para el estudio y comprensión de conceptos básicos en destilación multicomponente. En un trabajo posterior se podrá visualizar el desempeño del modelo dinámico a través de perturbaciones programadas en las condiciones de operación.   Palabras claves: destilación multicomponente; métodos cortos; interfaz gráfica de usuario; Phyton 2.5.In this work, we developed a graphical interface that determines by steady-state simulation the number of plates required for multicomponent distillation process and the composition of distillate and bottoms flow of a distillation tower using short-cut methods. The graphical user interface was built in the programming language Python 2.5, allows to present the input and output data for the case of distillation columns operating in steady state. The results of using the graphical interface shows a simple way to make preliminary designs of distillation towers and its potential as support material for the study and understanding of basic concepts in multicomponent distillation. In a later work it will can display the dynamic model performance through scheduled disturbances in operating conditions.   Keywords: multicomponent distillation; shorcut methods;graphical user interface; Phyton 2.5.

General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels.

Science.gov (United States)

Marcet, Brice; Becq, Frédéric; Norez, Caroline; Delmas, Patrick; Verrier, Bernard

2004-03-01

1. Cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel is defective during cystic fibrosis (CF). Activators of the CFTR Cl(-) channel may be useful for therapy of CF. Here, we demonstrate that a range of general anesthetics like normal-alkanols (n-alkanols) and related compounds can stimulate the Cl(-) channel activity of wild-type CFTR and delF508-CFTR mutant. 2. The effects of n-alkanols like octanol on CFTR activity were measured by iodide ((125)I) efflux and patch-clamp techniques on three distinct cellular models: (1). CFTR-expressing Chinese hamster ovary cells, (2). human airway Calu-3 epithelial cells and (3). human airway JME/CF15 epithelial cells which express the delF508-CFTR mutant. 3. Our data show for the first time that n-alkanols activate both wild-type CFTR and delF508-CFTR mutant. Octanol stimulated (125)I efflux in a dose-dependent manner in CFTR-expressing cells (wild-type and delF508) but not in cell lines lacking CFTR. (125)I efflux and Cl(-) currents induced by octanol were blocked by glibenclamide but insensitive to 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid, as expected for a CFTR Cl(-) current. 4. CFTR activation by octanol was neither due to cell-to-cell uncoupling properties of octanol nor to an intracellular cAMP increase. CFTR activation by octanol requires phosphorylation by protein kinase-A (PKA) since it was prevented by H-89, a PKA inhibitor. 5. n-Alkanols chain length was an important determinant for channel activation, with rank order of potencies: 1-heptanoloctanoloctanol<1-decanol. Our findings may be of valuable interest for developing novel therapeutic strategies for CF.

Gráficos difusos versus gráficos tradicionales para el control de procesos por atributos

Directory of Open Access Journals (Sweden)

Vivian Lorena Chud Pantoja

2017-05-01

Full Text Available Los gráficos de control son una buena herramienta controlar procesos. Han sido ampliamente utilizados —y aún ahora se utilizan— en la mayoría de los procesos manufactureros. Sin embargo, se han presentado propuestas orientadas a mejorar el desempeño de los mismos, principalmente en los aspectos referentes a la incertidumbre y ambigüedad existente en los datos. En este sentido, los gráficos de control difusos son una alternativa valiosa para mejorar el desempeño de los gráficos tradicionales. Se presenta, entonces, una comparación de los gráficos de control Shewhart (tradicionales y los gráficos de control difusos por atributos, con el objetivo de establecer las similitudes y diferencias existentes entre las dos metodologías. De esta manera, se desarrolla un ejemplo numérico de un gráfico tradicional c y gráficos difusos construidos a partir de las siguientes técnicas de transformación: moda difusa, mediana difusa, rango medio difuso y enfoque difuso directo. Para realizar una comparación se utilizaron las reglas de evaluación de patrones de comportamiento no natural en un gráfico de control. A partir de los resultados de la comparación realizada en esta investigación se concluye que al utilizar las reglas de evaluación en ambos gráficos con los mismos datos no se obtienen diferencias en los resultados. (Abstract. Control charts are the main tool in the process control. They have been widely used and are still used in most manufacturing processes. However, proposals have emerged that seek to improve their performance, mainly about topics which involve the vagueness and uncertainty of the data. In this sense, fuzzy control charts area an important alternative for improve the performance of control charts. We present a comparison of Shewhart control charts (traditional and fuzzy control charts for attributes with the aim of establishing similarities and differences between the two methodologies. We develop a numerical

Gráficas lineales: un proceso de significación a partir de su uso en ingeniería

Directory of Open Access Journals (Sweden)

Isabel Tuyub Sánchez

2017-10-01

Full Text Available En este escrito se analiza el uso de gráficas lineales en una maestría en ingeniería con la intención de generar una base de significación para el desarrollo de pensamiento matemático funcional. Esta investigación de corte socioepistemológico muestra tres casos ilustrativos sobre cómo esta comunidad académico-científica usa gráficas cartesianas. Se evidencian significados propios que provienen del uso de conocimiento matemático y que se integran en una significación mayor con una riqueza en la articulación de nociones como pendiente de rectas y puntos de intersección. El objetivo es mostrar la factibilidad de un cambio didáctico de los objetos hacia las prácticas, ya que estas favorecen un desarrollo intencional de usos del conocimiento matemático, propuesta que puede permear a lo largo del contexto escolar como una herramienta para el desarrollo de pensamiento matemático.

El Pop como expresión gráfica de la resistencia cultural catalana

Directory of Open Access Journals (Sweden)

María Àngels Fortea Castillo

2017-06-01

Full Text Available En los años sesenta, en Cataluña (España una de las formas de oposición pacífica contra la dictadura de Franco y sus directrices culturales fue la puesta en marcha de una renovada industria cultural. Como resultado se asistió a la aparición de una importante producción cultural en lengua catalana de gran calidad, al punto que el estilo Pop se convirtió, en el año 1968, en la expresión gráfica de la resistencia cultural. Las discográficas de nuevo cuño, fundadas en el momento en que la canción popular se convirtió en el mejor medio de difusión del catalán, fueron las primeras en aplicar los rasgos del Pop, de clara influencia norteamericana, evolucionando con el tiempo hacia una versión autóctona que recuperó la tradición gráfica de Cataluña.

12 CFR 508.8 - Default.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Default. 508.8 Section 508.8 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.8 Default. If the subject individual fails to file a petition for a...

Gráficos de control basados en la variación de un rango multivariante

OpenAIRE

Canales Florencio, Carolina

2016-01-01

El presente TFG consiste en implementar una serie de gráficos de control para observaciones multivariantes a partir de un rango basado en la centralidad de los datos. Este tipo de gráficos de control se inspiran en los que introdujo Liu [8], en los cuales para cada observación multivariante se obtiene su rango, es decir la proporción de observaciones históricas que son menos profundas que ella. Para una muestra, de carácter multivariante, y un conjunto de observaciones históricas se obt...

Instalación solar fotovoltaica aislada para una industria de artes gráficas

OpenAIRE

MUÑOZ PRADES, ÓSCAR

2018-01-01

El alumno diseñará una instalación solar fotovoltaica aislada de la red eléctrica, para suministrar los consumos necesarios a una industria de artes gráficas. Realizando tanto el diseño de la instalación como su presupuesto y amortización. TFGM

Quality surveillance for steel forgings of SA508 Gr.3 used on the main NI equipment of AP1000 nuclear island

International Nuclear Information System (INIS)

Liu Lizhao

2011-01-01

Being a type of steel with ideal weldability, outstanding ability of anti-neutron irradiation embitterment and good property of fracture toughness and impact toughness, the steel of ASME SA508-3 was used widely for the nuclear island equipment of PWR Nuclear Power Plant. For the 3rd generation nuclear power plant AP1000, all large forgings and some critical components of the SG, RV and PRZ adopt this steel. Through analysis on the critical technical points during manufacturing of the SA508-3 forgings, this article try to identify the key points should be paid attention during the quality surveillance for this type of forgings, and to put forward the supervision method and focus during quality surveillance activities. (author)

Intenciones proyectuales / trazas de representación. Intenciones en la representación gráfica de la arquitectura.

Directory of Open Access Journals (Sweden)

Dr. Arq. Carlos Pantaleón Panaro

2015-12-01

Full Text Available Este artículo sintetiza la investigación llevada a cabo como docente de Representación y Proyecto de Arquitectura en la Universidad de la República, Uruguay, cuyo objetivo primordial es generar los conocimientos necesarios para que el estudiante elabore los criterios que le permitan incorporar y aplicar los recursos gráfcos más efcaces y adecuados para expresar sus ideas e intenciones como proyectista de arquitectura. La imagen gráfca adquiere, en el proceso de enseñanza/aprendizaje de la arquitectura, una doble signifcación. Juega como mediadora entre docente y estudiante durante los procesos de proyectación en el Taller de Proyecto y constituye el medio habitual para el conocimiento de la obra real en sustitución de la experiencia vivencial. La efcacia de la comunicación en todas estas instancias, depende del buen manejo del recurso expresivo, de la validez de la imagen gráfca, cuya efciencia requiere la máxima coherencia entre las intenciones proyectuales del arquitecto y las cualidades de la obra representada por la imagen. La investigación parte de la hipótesis de que existen recursos expresivos para comunicar las cualidades de la obra que trascienden los recursos basados exclusivamente en los códigos consagrados por los sistemas tradicionales de representación. Estos recursos expresivos no están pautados ni por la geometría euclidiana ni por una normativa reconocida. Su manejo queda librado al sentido común y a la sensibilidad del proyectista, no obstante sean decisivos para transmitir efcazmente gran parte de las cualidades de una obra de arquitectura, especialmente aquellas que escapan a sus rasgos geométricos.

Study on Material Selection of Reactor Pressure Vessel of SCWR

Science.gov (United States)

Ma, Shuli; Luo, Ying; Yin, Qinwei; Li, Changxiang; Xie, Guofu

This paper first analyzes the feasibility of SA-508 Grade 3 Class 1 Steel as an alternative material for Supercritical Water-Cooled Reactor (SCWR) Reactor Pressure Vessel (RPV). This kind of steel is limited to be applied in SCWR RPV due to its quenching property, though large forging could be accomplished by domestic manufacturers in forging aspect. Therefore, steels with higher strength and better quenching property are needed for SWCR RPV. The chemical component of SA-508 Gr.3 Cl.2 steel is similar to that of SA-508 Gr.3 Cl.1 steel, and more appropriate matching of strength and toughness could be achieved by the adjusting the elements contents, as well as proper control of tempering temperature and time. In light of the fact that Cl.2 steel has been successfully applied to steam generator, it could be an alternative material for SWCR RPV. SA-508 Gr.4N steel with high strength and good toughness is another alternative material for SCWR RPV. But large amount of research work before application is still needed for the lack of data on welding and irradiation etc.

Gráficas y tablas estadísticas en la prueba de selección universitaria chilena

OpenAIRE

Díaz-Levicoy, Danilo; Parraguez, Rafael; Sánchez, Juan C.

2015-01-01

En este artículo presentamos los resultados de un análisis de las preguntas en las que intervienen gráficos y tablas de la sección de estadística y probabilidad en los facsímiles de la Prueba de Selección Universitaria (PSU) en los procesos de admisión 2005 al 2015. La metodología seguida en esta investigación es de tipo cualitativa, descriptiva y mediante análisis de contenido. Dentro de los resultados se destacan un predominio de tablas estadísticas, gráficos de barras, nivel de lectura “le...

Elaboración del Manual de Gestión de Calidad Imprenta Gráfica Center

OpenAIRE

Burgulla Zelada, Nathaly Gabriela

2013-01-01

El manual de calidad de la Imprenta Gráfica Center, define la política de calidad y el Sistema de Gestión de Calidad de la organización, orientadas en la satisfacción del cliente. La elaboración del manual de calidad está basada en la identificación y la interacción entre ellos. Además considero la realización de documentos necesarios para cumplir con los requisitos de la norma ISO 9001:2008 Departamento de Construcciones Arquitectónicas, Ingeniería del Terreno y Mecánica de los Medios Con...

Highly preferential association of NonF508del CF mutations with the M470 allele.

Science.gov (United States)

Ciminelli, B M; Bonizzato, A; Bombieri, C; Pompei, F; Gabaldo, M; Ciccacci, C; Begnini, A; Holubova, A; Zorzi, P; Piskackova, T; Macek, M; Castellani, C; Modiano, G; Pignatti, P F

2007-01-01

On the basis of previous findings on random individuals, we hypothesized a preferential association of CF causing mutations with the M allele of the M470V polymorphic site of the CFTR gene. We have determined the M/V-CF mutation haplotype in a series of 201 North East Italian and 73 Czech CF patients who were not F508del homozygotes, as F508del was already known to be fully associated with the M allele. Out of 358 not F508del CF genes, 84 carried the V allele and 274 the less common M allele. In the N-E Italian population, MM subjects have a risk of carrying a CF causing mutation 6.9x greater than VV subjects when F508del is excluded and 15.4x when F508del is included. In the Czech population a similar, although less pronounced, association is observed. Besides the possible biological significance of this association, the possibility of exploiting it for a pilot screening program has been explored in a local North East Italian population for which CF patients were characterized for their CF mutation. General M470V genotyping followed by common CF mutation screening limited to couples in which each partner carries at least one M allele would need testing only 39% of the couples, which contribute 89% of the total risk, with a cost benefit.

Revisión ambiental inicial en la empresa gráfica Sancti-Spíritus.

Directory of Open Access Journals (Sweden)

Jesús Valentín Cuellar Díaz

2007-03-01

Full Text Available El presente trabajo se origina a partir de la necesidad de las empresas gráficas cubanas de adoptar herramientas eficaces de gestión ambiental. Con el objetivo de conocer la brecha existente entre el estado actual de la Empresa Gráfica Sancti-Spíritus y los requisitos de la ISO 14001 para la implantación de un Sistema de Gestión Ambiental (SGA; se realizaron entrevistas, inspecciones in situ, revisiones de informes de auditorías y revisiones ambientales previas. Este trabajo permitió conocer los aspectos ambientales significativos de la organización, identificar las fortalezas y debilidades relacionadas con su desempeño actual, aportó los elementos básicos para establecer la política ambiental y diseñar el SGA que implantará la organización. Permitió elaborar un plan de acción, cuyo cumplimiento posibilitará reducir las no conformidades existentes, que constituyen barreras para la implantación del SGA.

Uso y cantidad de información de gráficos en materiales didácticos de Física

OpenAIRE

Idoyaga, Ignacio

2017-01-01

Se plantea un primer estudio de las representaciones gráficas presentes en el material didáctico de un curso de física universitaria, 279 en total. Se identificaron los tipos de representaciones gráficas. Se discriminaron los usos didácticos y científicos, y la cantidad de información intrínseca y extrínseca de los gráficos. La metodología propuesta recurrió a la estadística descriptiva e inferencial. Predominaron los gráficos cartesianos de uso didáctico expositivo y de uso científico teóric...

31 CFR 50.8 - Procedure for requesting determinations of controlling influence.

Science.gov (United States)

2010-07-01

... determinations of controlling influence. 50.8 Section 50.8 Money and Finance: Treasury Office of the Secretary of... determinations of controlling influence. (a) An insurer or insurers not having control over another insurer under... controlling influence under § 50.5(c)(4)(i) through (iv) or otherwise to request a determination of...

Study on corrosion resistance of A106Gr.B and A672Gr.B60 in dynamic water loop with high temperature and pressure

International Nuclear Information System (INIS)

Tian Jue; Wang Hui; Li Xinmin

2014-01-01

Due to the low carbon and low alloy Cr content, flow accelerates corrosion prone to have a serious impact on safety. AP1000 is the most advanced nuclear power technology in recent years. The plant used A672Gr.B60 as an alternative feed pipe to reduce the impact of flow accelerated corrosion. The impact of different flow rates, alkaline agent type and material property on A672Gr.B60 and A106Gr.B were characterized by scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS) and X-ray photoelectronic spectroscopy (XPS). After 336 h experiments were conducted, results show that the corrosion rate of A672Gr.B60 is much lower than that of A106Gr.B, and the density of oxidation film on A672Gr.B60 is superior to A106Gr.B. Ethanolamine (ETA) as an alkaline agent is better to reduce FAC to A106Gr.B, and it also can make the oxidation film become denser. Changes in flow rate will affect the size, shape and distribution of the oxide particles, and will also affect the thickness of the oxide film. Both of two materials were composed by Fe 3 O 4 . (authors)

Comportamiento del acero de baja aleación SA-508 y del acero al carbono A-410b en las condiciones de operación y parada del circuito primario de los reactores de agua ligera tipo PWR

Directory of Open Access Journals (Sweden)

García-Redondo, María del Sol

2000-04-01

Full Text Available The corrosion rate of low alloy steel SA-508 and carbon steel A-410b in simulated operation and shutdown conditions of pressurized water reactor has been determined. Moreover potentiodynamic polarization curves and galvanic effect through coupling of AISI-304 have been carried out under shutdown simulated condition.

En este trabajo se ha determinado la cinética de corrosión del acero de baja aleación SA-508 y del acero al carbono A-410b en condiciones que simulan la operación y la parada de los reactores de agua ligera a presión. También se han realizado curvas de polarización potenciodinámica y se ha estudiado el acoplamiento galvánico con AISI-304 en condiciones de parada de los reactores de agua ligera a presión.

7 CFR 1207.508 - USDA costs.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false USDA costs. 1207.508 Section 1207.508 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Rules and Regulations General § 1207.508 USDA costs. Pursuant to § 1207.341 of the Plan the Board shall...

Rastros de la sociedad de consumo en la redefinición de la gráfica

Directory of Open Access Journals (Sweden)

Silvia Dolinko

2014-10-01

Full Text Available Si la tradición del grabado circunscribió un repertorio de materiales y técnicas definido y acotado, este historial de convenciones y parámetros de realización se vio cuestionado y revertido desde mediados del siglo XX. El desarrollo de otro tipo de obra gráfica, opuesta a la línea convencional, implicó nuevas posibilidades tanto en términos iconográficos como materiales. Esta línea encuentra dos ejemplos clave en la obra de Jean Dubuffet y Robert Rauschenberg. Si ambos constituyen pilares de la ruptura del canon gráfico europeo y norteamericano, algunos artistas latinoamericanos también produjeron corpora de obras que otorgaron una dimensión original a la gráfica de los años sesenta. En este sentido, entiendo que la obra del argentino Antonio Berni dialoga con la producción contemporánea de Rauschenberg. Berni comienza a incorporar en 1962 materiales propios de la sociedad de consumo en sus xilografías de gran tamaño de la serie de Juanito Laguna con las que ese año obtiene el Gran Premio al Grabado en la XXXI Bienal de Venecia. Algunos años después, Liliana Porter retomó la temática de los rastros y desechos. Sus fotograbados Arruga de 1968 o sus instalaciones con papeles arrugados presentados en Caracas y Santiago de Chile al año siguiente implicaron una reflexión sobre las derivas de la materialidad a partir de la imagen de la destrucción de un soporte básico para el propio médium como es el papel. Las obras de estos artistas desmontaron y redefinieron los límites de esta producción, reciclando objetos descartados o apuntando a una deconstrucción conceptual del sentido canónico de la disciplina. Plantearon una alternativa experimental que se enfrentó crítica pero a la vez dialógicamente con las modalidades convencionales de realización. A través de estos casos, este trabajo indaga acerca de una nueva gráfica sostenida a partir de la incorporación de elementos o sentidos extraños a su propio historial

La obra gráfica de Juan Carandell Pericay (I)

OpenAIRE

Naranjo-Ramírez, J.

2007-01-01

Revisión completa y exhaustiva de la obra gráfica del geólogo y geógrafo Juan Carandell (1893-1937). A través de dos artículos, publicados en sucesivos números de la misma revista, se procedió a la identificación, catalogación y clasificación de todos sus gráficos, mayoritariamente de carácter científico, así como a una restauración de los mismos; finalmente se ha realizado el estudio de toda esta producción gráfica, aportando en buen número de casos también la reproducción física en el seno ...

MathGR: a tensor and GR computation package to keep it simple

OpenAIRE

Wang, Yi

2013-01-01

We introduce the MathGR package, written in Mathematica. The package can manipulate tensor and GR calculations with either abstract or explicit indices, simplify tensors with permutational symmetries, decompose tensors from abstract indices to partially or completely explicit indices and convert partial derivatives into total derivatives. Frequently used GR tensors and a model of FRW universe with ADM type perturbations are predefined. The package is built around the philosophy to "keep it si...

Desarrollo de una aplicación para gráficos de control de calidad de procesos industriales

OpenAIRE

Flores Sánchez, Miguel Alfonso

2013-01-01

El presente trabajo tiene por objeto crear una aplicación para el control estadístico de la calidad basado en un entorno gráfico cuyo motor de cálculo sea el lenguaje R. Se implementan los gráficos de control de calidad más utilizados en este campo mediante una aplicación específica sobre la base del desarrollo de una librería que utiliza algunas librerías estándar para el control de calidad que se encuentran en R. El nombre de la librería es qcr que corresponde a las siglas Quality Control a...

Lazos fuertes y proveedores múltiples de apoyo: comparación de dos formas de representación gráfica de las redes personales

Directory of Open Access Journals (Sweden)

ISIDRO MAYA JARIEGO

2005-01-01

Full Text Available En este artículo examinamos el impacto de dos formas diferentes de representación visual de las redes personales de 208 universitarios en la percepción de los observadores. Siguiendo un enfoque de experimentación, comparamos las reacciones e interpretaciones de 173 encuestados al observar gráficos de sus redes personales que representan (a los lazos fuertes o (b la multiplicidad de tipos de ayuda de un conjunto de 25 actores de su entorno personal. Los participantes mostraron preferencia por el gráfico que subraya las funciones de apoyo social de su red. A juicio de los entrevistados, el gráfico que representa la multiplicidad de los proveedores de apoyo social facilita la identificación de actores clave, aporta información más novedosa, refleja adecuadamente la posición de ego en la estructura de relaciones y es, en general, una mejor representación de su red personal. Sin embargo, la representación de los lazos fuertes facilita la identificación de agrupaciones en la red personal. Basándonos en los resultados, discutimos la pertinencia de este método de exploración, elicitación y validación de las redes personales de los encuestados.

12 CFR 508.10 - Burden of persuasion.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Burden of persuasion. 508.10 Section 508.10 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.10 Burden of persuasion. The petitioner has the burden of...

ETC 408/508: Technical Editing

Science.gov (United States)

Charlton, Michael

2013-01-01

ETC 408/508: Technical Editing is a cross-listed undergraduate and graduate course at Missouri Western State University, an open admissions public university with approximately 6,000 students. 508 is an elective course for students in the Master of Applied Arts in Written Communication degree and highly recommended for those in the Technical…

Creatividad gráfica y percepción visual en alumnos de 1º de Educación Primaria

OpenAIRE

Diego-Nieto, Vera

2013-01-01

El objetivo de la presente investigación es analizar la relación entre percepción visual y creatividad gráfica, en una muestra de 31 alumnos de 1º de Educación Primaria, con edades comprendidas entre 6 y 7 años. Se utilizó el Test de Desarrollo de la Percepción Visual de Marianne Frostig (1964) y el Test de Pensamiento Creativo Torrance (1966). Los resultados del estudio muestran correlaciones positivas y estadísticamente significativas respecto a los resultados totales de p...

Gr/gr deletions on Y-chromosome correlate with male infertility: an original study, meta-analyses, and trial sequential analyses

Science.gov (United States)

Bansal, Sandeep Kumar; Jaiswal, Deepika; Gupta, Nishi; Singh, Kiran; Dada, Rima; Sankhwar, Satya Narayan; Gupta, Gopal; Rajender, Singh

2016-02-01

We analyzed the AZFc region of the Y-chromosome for complete (b2/b4) and distinct partial deletions (gr/gr, b1/b3, b2/b3) in 822 infertile and 225 proven fertile men. We observed complete AZFc deletions in 0.97% and partial deletions in 6.20% of the cases. Among partial deletions, the frequency of gr/gr deletions was the highest (5.84%). The comparison of partial deletion data between cases and controls suggested a significant association of the gr/gr deletions with infertility (P = 0.0004); however, the other partial deletions did not correlate with infertility. In cohort analysis, men with gr/gr deletions had a relatively poor sperm count (54.20 ± 57.45 million/ml) in comparison to those without deletions (72.49 ± 60.06), though the difference was not statistically significant (p = 0.071). Meta-analysis also suggested that gr/gr deletions are significantly associated with male infertility risk (OR = 1.821, 95% CI = 1.39-2.37, p = 0.000). We also performed trial sequential analyses that strengthened the evidence for an overall significant association of gr/gr deletions with the risk of male infertility. Another meta-analysis suggested a significant association of the gr/gr deletions with low sperm count. In conclusion, the gr/gr deletions show a strong correlation with male infertility risk and low sperm count, particularly in the Caucasian populations.

La obra gráfica de Juan Carandell Pericay (y II)

OpenAIRE

Naranjo-Ramírez, J.

2007-01-01

Revisión completa y exhaustiva de la obra gráfica del geólogo y geógrafo Juan Carandell (1893-1937). A través de dos artículos, publicados en sucesivos números de la misma revista, se procedió a la identificación, catalogación y clasificación de todos sus gráficos, mayoritariamente de carácter científico, así como a una restauración de los mismos; finalmente se ha realizado el estudio de toda esta producción gráfica, aportando en buen número de casos también la reproducción física en el seno ...

9 CFR 93.508 - Articles accompanying swine.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Articles accompanying swine. 93.508 Section 93.508 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Swine § 93.508 Articles accompanying swine. No litter...

Determination of exposure rates from natural background radiation in Khartoum using LiF:Mg,Cu,P (GR-200) and CaSo4: Mn TLD chips

International Nuclear Information System (INIS)

Suliman, I.I.; Khangi, F.A.; Shaddad, I.A.; Suliman, I.A.; El Amin, O.I.

2002-01-01

The exposure rates from natural background radiation - including terrestrial gamma radiation and the ionizing component of cosmic rays - were measured for the first time in the city of khartoum using two types of TLD materials: LiF:Mg,Cu,P (GR-200) and CaSo 4 :Mn TLD chips. Measurements were performed at two sites simultaneously, one site was selected on land in the vicinity of the Sudan Atomic Energy Commission, for the purposes of the measurement of the total exposure rate outdoors, while the other site was located on a buoy anchored in the Blue Nile, and was selected to measure the exposure rate due to the ionizing component of cosmic rays. The investigations were conducted for periods of between 5 and 28 days. Calibration was performed on a selected number of dosimeters to determine the exposure rates at each site. The exposure rates from the ionizing component of cosmic rays in Khartoum were found to be respectively 33 nGy.h -1 and 30 nGy.h -1 , in the measurements performed within the scope of this work using GR-200 and CaSo 4 :Mn dosimeters, while the total values for exposure on land were found to be 45 nGy.h -1 and 42 nGy.h -1 respectively. These values compare reasonably well with other national averages reported in the UNSCEAR publication. The comparison of the results for the two dosimetric materials demonstrates both the sensitivity and suitability of GR-200 for the purposes of environmental monitoring (orig.)

Informatización de procesos de negocio mediante la ejecución de su modelo gráfico

OpenAIRE

Giráldez Betrón, José Ignacio; Gachet Páez, Diego

2009-01-01

A pesar de que hay mucho margen de eficiencia del que beneficiarse, muchos procesos de negocio no son informatizados por falta de una tecnología que permita hacerlo a bajo coste (especialmente en cuanto a personal cualificado y tiempo). En este artículo, presentamos una tecnología basada en agentes software que proporciona una respuesta parcial a este problema de costes mediante la ejecución de modelos gráficos de procesos de negocio. De tal forma, el secuenciamiento de acciones elementales n...

A-508 class 3 forgings for pressure vessels

International Nuclear Information System (INIS)

Comon, J.

1977-01-01

The manufacture of the forged parts of the first PWR nuclear pressure vessel installed in France started in the Creusot-Loire's Forge Plant in 1961. Since this date, more than 300 forgings of this type were delivered (flanges, rings, zones, and nozzles). The major part of these forgings were made of Mn, Ni, Mo steel (SA 508 class 3). They represent a population large and homogeneous enough to attempt a statistical analysis of chemical and mechanical test results. The aim of this analysis was double: (1) a better knowledge of the scattering of the results and a better estimate of what can be introduced or accepted in a specification, and (2) the setting up of correlations existing between these results, particularly between chemical analysis and mechanical test results. In addition to this statistical analysis concerning industrial results, several laboratory studies are presented, giving a more complete characterization of SA 508 class 3. All these results form a very complete documentation showing that SA 508 class 3 steel is suitable for the manufacture of large forged vessels requiring a high degree of reliability

The 2H(p,2p)n reaction at 508 MeV. Part I

International Nuclear Information System (INIS)

Punjabi, V.; Perdrisat, C.F.; Aniol, K.A.; Epstein, M.B.; Huber, J.P.; Margaziotis, D.J.; Bracco, A.; Davis, C.A.; Gubler, H.P.; Lee, W.P.; Poffenberger, P.R.; van Oers, W.T.H.; Postma, H.; Sebel, H.J.; Stetz, A.W.

1988-09-01

Differential cross sections for the reaction 2 H(p,2p)n at T p = 507 and 508 MeV are presented. The proton angle pairs chosen were 41.5 degrees with 41.4 and 50.0, 30.1 degrees with 44.0, 53,75, 61.0, and 68.0, 38.1 degrees -38.0 degrees, 44.1 degrees - 44.0 degrees, 47.1 degrees - 47.0 degrees and 50.0 degrees - 50.0 degrees. The data range over an energy window 100 MeV wide on one of the proton energies, the second energy being defined by the kinematic condition of a single neutron recoiling. The data are compared with the impulse approximation (IA) prediction and with the results of a nonrelativistic calculation of the six lowest-order Feynman diagrams describing the reaction. A previously known missing strength for the reaction in the small neutron recoil region is confirmed with much smaller experimental uncertainty; the missing strength persists up to 150 MeV/c neutron recoil. The onset of a systematic section excess relative to the IA near neutron recoil momentum 200 MeV is explored in detail. (Author) (37 refs., 17 figs.)

airGR: a suite of lumped hydrological models in an R-package

Science.gov (United States)

Coron, Laurent; Perrin, Charles; Delaigue, Olivier; Andréassian, Vazken; Thirel, Guillaume

2016-04-01

Lumped hydrological models are useful and convenient tools for research, engineering and educational purposes. They propose catchment-scale representations of the precipitation-discharge relationship. Thanks to their limited data requirements, they can be easily implemented and run. With such models, it is possible to simulate a number of hydrological key processes over the catchment with limited structural and parametric complexity, typically evapotranspiration, runoff, underground losses, etc. The Hydrology Group at Irstea (Antony) has been developing a suite of rainfall-runoff models over the past 30 years with the main objectives of designing models as efficient as possible in terms of streamflow simulation, applicable to a wide range of catchments and having low data requirements. This resulted in a suite of models running at different time steps (from hourly to annual) applicable for various issues including water balance estimation, forecasting, simulation of impacts and scenario testing. Recently, Irstea has developed an easy-to-use R-package (R Core Team, 2015), called airGR, to make these models widely available. It includes: - the water balance annual GR1A (Mouehli et al., 2006), - the monthly GR2M (Mouehli, 2003) models, - three versions of the daily model, namely GR4J (Perrin et al., 2003), GR5J (Le Moine, 2008) and GR6J (Pushpalatha et al., 2011), - the hourly GR4H model (Mathevet, 2005), - a degree-day snow module CemaNeige (Valéry et al., 2014). The airGR package has been designed to facilitate the use by non-expert users and allow the addition of evaluation criteria, models or calibration algorithms selected by the end-user. Each model core is coded in FORTRAN to ensure low computational time. The other package functions (i.e. mainly the calibration algorithm and the efficiency criteria) are coded in R. The package is already used for educational purposes. The presentation will detail the main functionalities of the package and present a case

Association between F508 deletion in CFTR and chronic pancreatitis risk.

Science.gov (United States)

Zhao, Dong; Xu, Yanzhen; Li, Jiatong; Fu, Shien; Xiao, Feifan; Song, Xiaowei; Xie, Zhibin; Jiang, Min; He, Yan; Liu, Chengwu; Wen, Qiongxian; Yang, Xiaoli

2017-09-01

The cystic fibrosis transmembrane conductance regulator (CFTR) has been reported to influence individual susceptibility to chronic pancreatitis (CP), but the results of previous studies are controversial. We performed a study to demonstrate the relationship between CFTR and CP. We searched PubMed, Scopus, and Embase for studies of patients with CP. Seven studies from 1995 to 2016 were identified, and included 64,832 patients. Pooled prevalence and 95% confidence intervals (CIs) were calculated. F508 deletion in CFTR was significantly positively associated with CP risk in the overall analysis (odds ratio [OR]=3.20, 95% CI: 2.30-4.44, I 2 =31.7%). In subgroup analysis stratified by ethnicity, F508 deletion was significantly associated with CP risk in Indian populations, using a fixed effects model (ORs=5.45, 95% CI: 2.52-11.79, I 2 =0.0%), and in non-Indian populations, using a random effects model (ORs=3.59, 95% CI: 1.73-7.48, I 2 =60.9%). At the same time, we found that Indians with F508 deletion had much higher CP prevalence than non-Indians. Interestingly, F508 deletion was also associated with CP and idiopathic CP risk in subgroup analysis stratified by aeitiology, using the fixed effects model. Based on current evidence, F508 deletion is a risk factor for CP, and Indians with F508 deletion have much higher CP morbidity. Copyright © 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Creep of A508/533 Pressure Vessel Steel

Energy Technology Data Exchange (ETDEWEB)

Richard Wright

2014-08-01

allowed by Code Case N-499-2 (now incorporated as an appendix to Section III Division 5 of the Code). This Code Case was developed with a rather sparse data set and focused primarily on rolled plate material (A533 specification). Confirmatory tests of creep behavior of both A508 and A533 are described here that are designed to extend the database in order to build higher confidence in ensuring the structural integrity of the VHTR RPV during off-normal conditions. A number of creep-rupture tests were carried out at temperatures above the 371°C (700°F) Code limit; longer term tests designed to evaluate minimum creep behavior are ongoing. A limited amount of rupture testing was also carried out on welded material. All of the rupture data from the current experiments is compared to historical values from the testing carried out to develop Code Case N-499-2. It is shown that the A508/533 basemetal tested here fits well with the rupture behavior reported from the historical testing. The presence of weldments significantly reduces the time to rupture. The primary purpose of this report is to summarize and record the experimental results in a single document.

MINERAL NITROGEN SOURCES (N-NO3- AND N-NH4+ ON GROWTH OF GRÁPIA (Apuleia leiocarpa (Vog. Macbride SEEDLINGS

Directory of Open Access Journals (Sweden)

Fernando Teixeira Nicoloso

2010-08-01

Full Text Available Grápia (Apuleia leiocarpa (Vog. Macbride is an important native forest species that has been in extinction process. The aim of this study was to evaluate the effect of mineral nitrogen source on growth of grápia seedlings. Five variations in the concentration of N-NO3- and N-NH4+ (5:0, 4:1, 2,5:2,5, 1:4, and 0:5 mM of N were tested in an entirely random statistical design with 16 replicates. The experimental unity consisted of a vessel containing 3,0 kg of a Paleudalf soil and two plants, under glasshouse conditions. From 60 to 150 days after fertilization (DAF, the plant growth and soil pH were monthly analyzed from four replicates randomly taken. Independently of the nitrogen source used, the soil pH decreased, and on 150 DAF the smallest pH variation was 0.33 and the largest one was 0.47 pH units, respectively, on treatments with 5 N-NO3-:0 N-NH4+ and 0 N-NO3-:5 N-NH4+ ratios. The presence of N-NH4+, from 1 to 5 mM, induced necrosis in old leaves and their ulterior abscission. To 150 DAF, in the presence of 5 mM N-NH4+, the plant survival was reduced to 31%. The effect of nitrogen sources on plant growth appeared to be depended on plant age and/or of their transformations in the soil. To 120 DAF, the presence of N-NH4+ from 2,5 to 5 mM reduced the number of stalk nodes, plant height, stem diameter, dry weight of leaves, of stem, of roots, and of the whole plant. However, to 150 DAF, because of the regain on the growth rate, these differences were not observed, with exception of the root/shoot dry weight ratio that was reduced on the exclusive presence of N-NH4+. The suitable N-NO3-:N-NH4+ ratio in the fertilization to grow grápia seedlings, can not exceed, respectively, 4:1.

12 CFR 508.13 - Decision of the Office.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Decision of the Office. 508.13 Section 508.13 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.13 Decision of the Office. (a) Within 30 days after the recommended decision has been certifie...

Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization.

Science.gov (United States)

Millan, M J; Newman-Tancredi, A; Lochon, S; Touzard, M; Aubry, S; Audinot, V

2002-04-01

Although several tritiated agonists have been used for radiolabelling serotonin (5-hydroxytryptamine, 5-HT)(1B) receptors in rats, data with a selective, radiolabelled antagonist have not been presented. Inasmuch as [3H]GR125,743 specifically labels cloned, human and native guinea pig 5-HT(1B) receptors and has been employed for characterization of cerebral 5-HT(1B) receptor in the latter species [Eur. J. Pharmacol. 327 (1997) 247.], the present study evaluated its utility for characterization of native, cerebral 5-HT(1B) sites in the rat. In homogenates of frontal cortex, [3H]GR125,743 (0.8 nM) showed rapid association (t(1/2)=3.4 min), >90% specific binding and high affinity (K(d)=0.6 nM) for a homogeneous population of receptors with a density (B(max)) of 160 fmol/mg protein. In competition binding studies, affinities were determined for 15 chemically diverse 5-HT(1B) agonists, including 2-[5-[3-(4-methylsulphonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indole-3-yl]ethylamine (L694,247; pK(i), 10.4), 5-carboxamidotryptamine (5-CT; 9.7), 3-[3-(2-dimethylamino-ethyl)-1H-indol-6-yl]-N-(4-methoxybenzyl)acrylamide (GR46,611; 9.6), 5-methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole (RU24,969; 9.5), dihydroergotamine (DHE; 8.6), 5-H-pyrrolo[3,2-b]pyridin-5-one,1,4-dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl (CP93,129; 8.4), anpirtoline (7.9), sumatriptan (7.4), 1-[2-(3-fluorophenyl)ethyl]-4-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]piperazine (L775,606; 6.4) and (minus sign)-1(S)-[2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]-N-methyl-3,4-dihydro-1H-2-benzopyran-6-carboxamide (PNU109,291; <5.0). Similarly, affinities were established for 13 chemically diverse antagonists, including N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-4-(4-pyridyl)benzamide (GR125,743; pK(i), 9.1), (-)cyanopindolol (9.0), (-)-tertatolol (8.2), N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiozol-3-yl)biphenyl-4-carboxamide (GR127,935; 8.2), N-[3-(1,4

Aceleración del método de las funciones base características por medio de tarjetas gráficas

OpenAIRE

Pérez Sanz, Juan Ignacio

2015-01-01

En esta tesis se aborda el proceso de transformación de un método numérico, el Método de las Funciones Base Características, para que pueda ser ejecutado en una tarjeta gráfica que acepte la tecnología CUDA. Las tarjetas gráficas tienen una forma de ejecutar los programas radicalmente diferente a los computadores tradicionales, lo que exige grandes modificaciones en los algoritmos al ser trasladados de éstos últimos a ellas. Sin embargo, también pueden ofrecer una importante ganancia en el re...

INFLUENCIA DE LA PRESIÓN ATMOSFÉRICA EN LAS TRANSMISIONES A FRECUENCIA 2.4 GHz

OpenAIRE

González Romero, Pedro Vicente; Espina Ávila, Luis Gerardo

2012-01-01

La presente investigación se planteó como propósito fundamental determinar la influencia de la presión atmosférica sobre una señal transmitida en una frecuencia de 2.4 GHz. La investigación es de tipo explicativa, con diseño metodológico experimental. Mediante ella se obtiene la atenuación de una señal de 2.4GHz a diferentes presiones atmosféricas y se determinan las gráficas que muestran el comportamiento observado. Como resultado de esta investigación se observó que sí existe una influencia...

Nuevos fragmentos del Éxodo griego (Ms. Gr. Bibl. f. 4 [P

Directory of Open Access Journals (Sweden)

M. V. Spottorno

1976-12-01

Full Text Available Publication of the unedited Ms. Gr. Bibl. f. 4 (P containing Ex. 9, 1. 2. 6-8. 10. 11. 13. 14, with paleographical commentary and discussion on its insertion in the Septuagint text history. The authors maintain that it belongs to a revision of the Septuagint implying on one side an approach to the original Hebrew and on the other side stylistic modifications. This revision could be parahexaplaric and perhaps prehexaplaric.

Diseño gráfico en el espacio público. Aplicación a un hospital infantil de Sevilla

OpenAIRE

Acosta Naranjo, Enrique

1997-01-01

La elección de un tema tan original e interesante como el que se presenta en este trabajo de investigación se debe a un cúmulo de circunstancias coincidentes y favorables. La posibilidad de realizar conjuntamente una línea de investigación en la que participara el diseño gráfico como actividad creativa y artística, su adecuación a un espacio público y su implantación a un hospital infantil ejerciendo funciones lúdicas, educativas y ambientales, ha representado un reto dentro del campo del dis...

Capacidad antifúngica de sobrenadantes libres de células obtenidos de la fermentación de un sustrato de “panela” con gránulos de kefir de agua

Directory of Open Access Journals (Sweden)

Carlos Andrés Caro Velez

2015-07-01

Full Text Available El kefir de agua (KA es una bebida fermentada medianamente ácida elaborada con soluciones azucaradas y fermentada por un consorcio de microorganismos, principalmente bacterias ácido lácticas (BAL y levaduras (LEV, embebidas en un polisacárido llamado gránulo de KA. La presencia de hongos y sus toxinas es un problema de la producción de alimentos, como Aspergillus ochraceus y sus micotoxinas especialmente en café y vino. Entre algunas alternativas que se han evaluado para su inhibición se incluyen las bacterias ácido lácticas y productos fermentados en general. El objetivo principal de esta investigación fue evaluar la capacidad del KA en inhibir o retrasar el crecimiento de A. ochraceus. Se emplearon 8 sobrenadantes libres de células (SLC obtenidos de diferentes fermentaciones de panela con gránulos de KA y con diferentes concentraciones de ácidos orgánicos (láctico y acético. Se hicieron fermentaciones con gránulos de KA en solución de panela por periodos de 32,5 h, a 25, 30 y 37 °C. Se determinaron la cinética de acidificación; el incremento de biomasa y se hizo el recuento de los grupos de microorganismos que componen el gránulo. A 25 °C se determinó el mayor aumento de biomasa (92%. La temperatura de fermentación afectó el recuento de los microorganismos que conforman el gránulo, principalmente las BAL, disminuyendo su cantidad a la máxima temperatura de fermentación (37 °C (6,4x107UFC ml-1, comparado con la mínima temperatura (25 ºC (4,0x106 UFC ml-1. El fermento que presentó mayor actividad antifúngica fue el SLC5 (pH: 3,2; temperatura de fermentación: 30 °C. El poder inhibitorio se atribuyó a los ácidos orgánicos producidos durante la fermentación, aunque no se puede descartar que hayan actuado otras sustancias no cuantificadas.Se pudo comprobar que el KA puede fermentar y aumentar su biomasa en un sustrato como el agua de panela y que sus SLC tienen la capacidad de reducir el crecimiento de A

Synthesis, crystal structure and DFT studies of N-(4-acetyl-5,5-dimethyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide

Science.gov (United States)

Gautam, P.; Gautam, D.; Chaudhary, R. P.

2013-12-01

The title compound N-(4-acetyl-5,5-dimethyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide ( III) was obtained from the reaction of 2-(propan-2-ylidene)hydrazinecarbothioamide ( II) with acetic anhydride instead of formation of the desired thiosemcarbazide derivative of Meldrum acid. The structures of II and III were established by elemental analysis, IR, NMR, Mass and X-ray crystallographic studies. II crystallizes in triclinic system, sp. gr. Z = 2; III crystallizes in the monoclinic system, sp. gr. P21/ c, Z = 8. Density functional theory (DFT) calculations have been carried out for III. 1H and 13C NMR of III has been calculated and correlated with experimental results.

Synthesis, crystal structure and DFT studies of N-(4-acetyl-5,5-dimethyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide

International Nuclear Information System (INIS)

Gautam, P.; Gautam, D.; Chaudhary, R. P.

2013-01-01

The title compound N-(4-acetyl-5,5-dimethyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide (III) was obtained from the reaction of 2-(propan-2-ylidene)hydrazinecarbothioamide (II) with acetic anhydride instead of formation of the desired thiosemcarbazide derivative of Meldrum acid. The structures of II and III were established by elemental analysis, IR, NMR, Mass and X-ray crystallographic studies. II crystallizes in triclinic system, sp. gr. P-bar1 Z = 2; III crystallizes in the monoclinic system, sp. gr. P2 1 /c, Z = 8. Density functional theory (DFT) calculations have been carried out for III. 1 H and 13 C NMR of III has been calculated and correlated with experimental results

27 CFR 19.508 - Consignor premises.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Consignor premises. 19.508 Section 19.508 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT...) Spirits or denatured spirits produced from petroleum, natural gas, or coal may not be transferred to...

La realidad al cuadrado : Representaciones sobre lo político en el humor gráfico del diario Clarín (1973-1983)

OpenAIRE

Levín, Florencia Paula

2015-01-01

En esta investigación se intenta bordear a partir del análisis sistemático de las representaciones sobre lo político construidas por el humor gráfico del diario Clarín, que por entonces ya era el matutino de mayor tirada a nivel nacional. Dado el amplio margen de inespecificidad y ambigüedad del término, es importante aclarar que cuando me refiero al "humor gráfico" del diario Clarín estoy aludiendo conjuntamente a los "cartoon" de Landrú publ...

Fossiler i Grønland. 2. del

DEFF Research Database (Denmark)

Harper, David Alexander Taylor; Lindow, Bent Erik Kramer

2009-01-01

Dette er anden og sidste del af POST Greenlands serie om fossiler i Grønland med tre frimærker, der beretter om de mange og spændende fossilfund fra Grønland. Mærkerne fortsætter vores rejse gennem nogle af nøglebegivenhederne i livets historie, smukt illustreret af endnu flere unikke fossiler....... Disse tre fossiler, en plante, et bløddyr og et hvirveldyr, er fra de yngre aflejringer i Grønland med aldre spændende fra for 200 millioner og indtil kun 8.000 år siden....

Phenotypic variation within European carriers of the Y-chromosomal gr/gr deletion is independent of Y-chromosomal background

DEFF Research Database (Denmark)

Krausz, C; Giachini, C; Xue, Y

2008-01-01

of duplications and the Y-chromosomal haplogroup were characterised. Although the study had good power to detect factors that accounted for >or=5.5% of the variation in sperm concentration, no such factor was found. A negative effect of gr/gr deletions followed by b2/b4 duplication was found within...

Generación de ideas en el contexto organizacional: comprensiones a partir del estudio de una empresa del sector gráfico de Medellín.

Directory of Open Access Journals (Sweden)

Manuela Escobar Sierra

2014-12-01

Full Text Available En este artículo se analiza, a partir del estudio de una empresa del sector gráfico de Medellín (Colombia, el proceso de generación de ideas en el contexto organizacional y la caracterización, según el estilo cognitivo y las técnicas creativas, de la calidad de esas ideas. En el texto 1 se revisa la literatura sobre innovación, gestión del conocimiento y los estilos cognitivos, 2 se presenta la estrategia de investigación, que corresponde con el estudio de caso, 3 se explicita la recolección de datos realizada (que utiliza un juego gerencial compuesto por técnicas creativas, estilos cognitivos y criterios de calidad y se muestra el análisis de los datos (que hace uso del diseño de experimentos, constatando que el juego gerencial permite focalizar las capacidades relacionadas con la gestión del conocimiento y la innovación y 4 se evidencia la relación existente entre la interacción del estilo cognitivo y las técnicas creativas, así como su impacto en la calidad de las ideas generadas.

Proceso de trabajo, organización industrial y movilización obrera en la industria gráfica (1950-1975)

OpenAIRE

Ghigliani, Pablo

2014-01-01

En “Organización de la industria gráfica y conflictividad laboral (1940-1960)” analicé el modo en que la división entre el sector obra y el sector periodístico influyó la dinámica de la conflictividad laboral, impulsada por el establecimiento de pisos salariales distintos para tareas y esfuerzos idénticos. En realidad, dicha ponencia fue un sucedáneo del objetivo inicial de la investigación dada la falta de resultados tangibles: la relación entre proceso de trabajo, conflicto y movilización o...

Electrochemical treatment of 2, 4-dichlorophenol using a nanostructured 3D-porous Ti/Sb-SnO2-Gr anode: Reaction kinetics, mechanism, and continuous operation.

Science.gov (United States)

Asim, Sumreen; Zhu, Yunqing; Batool, Aisha; Hailili, Reshalaiti; Luo, Jianmin; Wang, Yuanhao; Wang, Chuanyi

2017-10-01

2, 4-dichlorophenol (2, 4-DCP) is considered to be a highly toxic, mutagenic, and possibly carcinogenic pollutant. This study is focused on the electrochemical oxidation of 2, 4-DCP on nanostructured 3D-porous Ti/Sb-SnO 2 -Gr anodes, with the aim of presenting a comprehensive elucidation of mineralization process through the investigation of influential kinetics, the reactivity of hydroxyl radical's and analysis of intermediates. High efficiency was achieved at pH of 3 using Na 2 SO 4 electrolytes at a current density of 30 mA cm -2 . Under the optimized conditions, a maximum removal of 2, 4-DCP of up to 99.9% was reached, whereas a TOC removal of 81% was recorded with the lowest EC TOC (0.49 kW h g -1 ) within 40 min of electrolysis. To explore the stability of the 3D-Ti/Sb-SnO 2 -Gr electrodes, a continuous electrochemical operation was established, and the consistent mineralization results indicated the effectiveness of the 3D-Ti/Sb-SnO 2 -Gr system concerning its durability and practical utilization. EPR studies demonstrated the abundant generation of OH radicals on 3D-Ti/Sb-SnO 2 -Gr, resulting in fast recalcitrant pollutant incineration. From dechlorination and the reactivity of the OH radicals, several intermediates including six cyclic byproducts and three aliphatic carboxylic acids were detected, and two possible degradation pathways were proposed that justify the complete mineralization of 2, 4-DCP. Copyright © 2017 Elsevier Ltd. All rights reserved.

Lactobacillus rhamnosus GR-1 enhances NF-kappaB activation in Escherichia coli-stimulated urinary bladder cells through TLR4

Directory of Open Access Journals (Sweden)

Karlsson Mattias

2012-01-01

Full Text Available Abstract Background Epithelial cells of the urinary tract recognize pathogenic bacteria through pattern recognition receptors on their surface, such as toll-like receptors (TLRs, and mount an immune response through the activation of the NF-kappaB pathway. Some uropathogenic bacteria can subvert these cellular responses, creating problems with how the host eliminates pathogens. Lactobacillus is a genus of lactic acid bacteria that are part of the microbiota and consist of many probiotic strains, some specifically for urogenital infections. Immunomodulation has emerged as an important mode of action of probiotic and commensal lactobacilli and given the importance of epithelial cells, we evaluated the effect of the urogenital probiotic Lactobacillus rhamnosus GR-1 on epithelial immune activation. Results Immune activation through the NF-kappaB pathway was initiated by stimulation of T24 urothelial cells with heat-killed Escherichia coli and this was further potentiated when cells were co-cultured with live L. rhamnosus GR-1. Heat-killed lactobacilli were poor activators of NF-kappaB. Concomitant stimulation of bladder cells with E. coli and L. rhamnosus GR-1 increased the levels of the pro-inflammatory cytokine TNF, whereas IL-6 and CXCL8 levels were reduced. Another probiotic, L. rhamnosus GG, was also able to potentiate NF-kappaB in these cells although at a significantly reduced level compared to the GR-1 strain. The transcript numbers and protein levels of the lipopolysaccharide receptor TLR4 were significantly increased after co-stimulation with E. coli and lactobacilli compared to controls. Furthermore, inhibition of TLR4 activation by polymixin B completely blocked the lactobacilli potentiation of NF-kappaB. Conclusions The immunological outcome of E. coli challenge of bladder cells was influenced by probiotic L. rhamnosus GR-1, by enhancing the activation of NF-kappaB and TNF release. Thus the urogenital probiotic L. rhamnosus GR-1

Retórica aplicada a la Enseñanza del Diseño Gráfico

Directory of Open Access Journals (Sweden)

Roberto Gamonal Arroyo

2011-11-01

Full Text Available Los conceptos fundamentales de la Retórica para la creación del discurso se pueden trasladar al Diseño Gráfico con la finalidad de construir piezas gráficas que son consideradas, a su vez, discursos visuales. En este sentido, tanto las operaciones retóricas como las figuras derivadas de ellas tienen un papel fundamental como elementos detonantes de la creatividad. Para evitar el uso de las figuras como un mero recurso estilístico, un error histórico cometido por la propia Retórica, éstas se convierten en la expresión figurada de un argumento en el que se modifica su grado cero para que resulte más llamativo e impactante a la audiencia a la que va dirigida el mensaje gráfico. A través de unas simples operaciones de adición, supresión, sustitución y permutación se producen variaciones de los elementos gráficos y de su grado cero de expresión (concepto del Grupo m que se cristalizan en figuras retóricas que generan nuevas composiciones con mayor potencia expresiva y creativa. En este artículo veremos cómo los estudiantes aplican estos conceptos retóricos para la conceptualización, creación y diseño de cubiertas para libros.

Recruitment of Gr1(+)CD11b (+)F4/80 (+) population in the bone marrow and spleen by irradiation-induced pulmonary damage.

Science.gov (United States)

Thanasegaran, Suganya; Ito, Sachiko; Nishio, Naomi; Uddin, Mohammad Nizam; Sun, Yang; Isobe, Ken-ichi

2015-04-01

Radiation-induced lung injury is a kind of sterile inflammation, which may lead to morbidity and mortality. The mechanism by which ionizing radiation activate the immune system is not well understood. In the present study, we have investigated the immunological responses induced by local irradiation-induced damage in mouse lung. The left lungs of C57BL/6 mice were irradiated at a high dose of 100 Gy. The histology of the lungs and spleen showed evidences of alveolar inflammation and congestion at 2 weeks after X-ray treatment. Also, prominent increase in cells expressing the cell surface markers, Gr(+)CD11b(+)F4/80(+) and Ly6C(+) Ly6G(+) were observed 2 weeks after X-ray treatment (100 Gy). Gr1(+)CD11b(+)F4/80(+) cell depletion by clodronate treatment reversed the histological effects and also failed to recruit Gr(+)CD11b(+) cells or F4/80(+) cells caused by irradiation. The origin of recruited Gr1(+)CD11b(+) cells was found to be a mixed resident and recruited phenotype.

Synthesis, crystal structure and DFT studies of N-(4-acetyl-5,5-dimethyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide

Energy Technology Data Exchange (ETDEWEB)

Gautam, P.; Gautam, D.; Chaudhary, R. P., E-mail: rpchaudhary65@gmail.com [Sant Longowal Institute of Engineering and Technology, Department of Chemistry (India)

2013-12-15

The title compound N-(4-acetyl-5,5-dimethyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide (III) was obtained from the reaction of 2-(propan-2-ylidene)hydrazinecarbothioamide (II) with acetic anhydride instead of formation of the desired thiosemcarbazide derivative of Meldrum acid. The structures of II and III were established by elemental analysis, IR, NMR, Mass and X-ray crystallographic studies. II crystallizes in triclinic system, sp. gr. P-bar1 Z = 2; III crystallizes in the monoclinic system, sp. gr. P2{sub 1}/c, Z = 8. Density functional theory (DFT) calculations have been carried out for III. {sup 1}H and {sup 13}C NMR of III has been calculated and correlated with experimental results.

El diseño gráfico: de las cavernas a la era digital

Directory of Open Access Journals (Sweden)

Lic. Itanel Bastos de Quadros Junior

1999-01-01

Full Text Available Los expertos discrepan sobre las raíces del diseño gráfico. Algunos identifican las pinturas rupestres como ejemplos ancestrales de los signos gráficos; otros reconocen sus formas embrionarias en Egipto, Grecia, México y Roma. Varios autores consideran que el diseño gráfico surge al mismo tiempo que la imprenta. Una corriente apunta a las vanguardias artísticas del inicio de este siglo. Otros, todavía, emplazan al pensamiento contemporáneo, con respecto al diseño gráfico, después de la segunda guerra mundial, como un fenómeno adjunto al fuerte desarrollo industrial y de los medios de comunicación.

Aproximación gráfica de la interfase de matano

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Juan Carlos Fallas Chinchilla

2010-10-01

Full Text Available La adecuada comprensión de los fenómenos de transporte en materiales ofrece múltiples ventajas, especialmente a la hora de razonar su aplicabilidad en distintas áreas de la ciencia e ingeniería. Dentro de los conceptos relevantes en el campo de la difusión, se encuentra la Interfase de Matano, siendo este un paso clave intermedio para la determinación de la difusividad en una serie de datos experimental.Dado que este concepto es descrito por una formulación matemática, el objetivo de este trabajo es lograr una aproximación gráfica a la Interfase de Matano.Para ejemplificar el proceso, un caso real es analizado. Con base en valores de concentración y penetración para determinados solutos y solventes, se genera una curva que se divide en forma aleatoria inicialmente, la cual separa las cantidades de masa difundida. Posteriormente, se plantea un juego de ecuaciones del área bajo la curva donde la incógnita es el valor de la Interfase de Matano. Al buscarse la equidad en la distribución de masa, las dos áreas deben ser iguales y el juego de ecuaciones se resuelve.Con esto se espera hacer accesible el uso de este concepto en pruebas de campo y de laboratorio.

Diagnóstico de la gestión empresarial: la industria gráfica y su efecto tributario en el período 1999-2004

OpenAIRE

Sánchez Tinoco, Jorge Honorato

2006-01-01

La presente investigación se origina y desarrolla a partir de la interrogante central ¿La evolución del sector de la industria gráfica contribuirá a la generación de un proceso de desarrollo económico y tendrá efectos positivos en la redistribución del ingreso?. El estudio propone realizar un diagnóstico de la industria gráfica y su efecto tributario, para lo cual plantea los objetivos siguientes: analizar la situación del sector y determinar los factores que obstaculizan su desarrollo; deter...

Algoritmos para visualización a través de módulos LCD gráficos

Directory of Open Access Journals (Sweden)

Yosvany Vento Ramos

2012-02-01

Full Text Available Normal 0 21 false false false ES X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} El desarrollo de sistemas embebidos (como el que se acomete en los laboratorios del Grupo de Investigaciones para el Diagnóstico Avanzado de Maquinarias(GIDAM de la universidad de Pinar del Río(UPR en general presenta limitaciones para realizar de manera autónoma la visualización de datos y resultados de procesamiento, así como para posibilitar una interfaz visual efectiva de interacción con los usuarios. Este problema encuentra solución en el empleo de pantallas de cristal líquido o módulos LCD (Liquid Cristal Display. Por ello, el objetivo de este trabajo consistió en desarrollar y validar un paquete de algoritmos de programación para un módulo gráfico LCD. El sistema desarrollado es una aplicación a microcontrolador para manejar el LCD. Inicialmente se logró la visualización esperada en forma de simulación, y posteriormente se desarrolló su implementación práctica. Se obtuvieron los resultados esperados, presentando las visualizaciones de las señales graficadas una calidad comparable con las de programas profesionales.

Problemas de saúde mental entre jovens grávidas e não-grávidas Mental health problems among pregnant and non-pregnant youth

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Valéria Garcia Caputo

2007-08-01

Full Text Available OBJETIVO: Estimar a prevalência de problemas de saúde mental em adolescentes primigestas e comparar seu perfil de saúde mental com o daquelas sexualmente ativas que nunca engravidaram. MÉTODOS: Estudo de corte transversal, comparativo entre dois grupos de adolescentes de 13 a 17 anos, em Marília, Estado de São Paulo, 2003-2004. A amostra incluiu 207 primigestas atendidas em programas de pré-natal de serviços públicos municipais urbanos e 308 estudantes de escolas estaduais, sexualmente ativas, que nunca engravidaram. Foram aplicados um instrumento de rastreamento para problemas de saúde mental em adolescentes (versão brasileira do Youth Self-Report e um questionário sobre fatores de risco para gravidez na adolescência. A análise estatística incluiu testes de qui-quadrado, exato de Fisher, U de Mann Whitney e modelos de regressão logística. RESULTADOS: Adolescentes grávidas e não-grávidas não diferiram quanto à prevalência do total de problemas de saúde mental (24,6% vs. 27,3%; p=0,50. Comparado às adolescentes não-grávidas, o grupo das primigestas apresentou maior prevalência de sintomas de ansiedade/depressão (24,2% vs. 15,3%; p=0,01 e sintomas de retraimento/depressão (13,0% vs, 4,5%; pOBJECTIVE: To estimate the prevalence of mental health problems in primiparous adolescents and to compare their mental health profile with the profile of sexually active adolescents who have never gotten pregnant. METHODS: Cross-sectional study that compared two groups of adolescents aged 13 to 17 years from a city in Southern Brazil, 2003-2004. The sample included 207 primiparous who attended prenatal care programs in urban public services, and 308 sexually active students from state public schools who had never gotten pregnant. A screening instrument to identify mental health problems in adolescents (Brazilian version of the Youth Self-Report was applied to the participants together with a questionnaire on risk factors for

29 CFR 779.508 - Eighteen-year minimum.

Science.gov (United States)

2010-07-01

... RETAILERS OF GOODS OR SERVICES Other Provisions Which May Affect Retail Enterprises Child Labor Provisions... 29 Labor 3 2010-07-01 2010-07-01 false Eighteen-year minimum. 779.508 Section 779.508 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL...

48 CFR 3045.508-2 - Reporting results of inventories.

Science.gov (United States)

2010-10-01

...: (1) Land and rights therein; (2) Other real property; (3) Plant equipment; (4) Special test equipment... SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) CONTRACT MANAGEMENT GOVERNMENT PROPERTY Management of Government Property in the Possession of Contractors 3045.508-2 Reporting results of...

Comprensión lectora y gráficos estadísticos en alumnos de cuarto grado de primaria

OpenAIRE

Triviño Duran, Luz Sthella; Sola Martínez, Tomás; Rivas Olivo, Mauro

2014-01-01

En este texto informamos sobre la valoración de un programa de mejora de la comprensión lectora, implementado en alumnos de cuarto grado de educación primaria (de 8 a 10 años de edad). Para esa valoración hemos realizado con los alumnos una actividad práctica relativa a la comprensión de gráficos estadísticos. La investigación realizada es exploratoria-descriptiva que incluye la aplicación de un instrumento (actividad práctica) y una descripción del nivel de comprensió...

Documentación gráfica de edificios históricos: principios, aplicaciones y perspectivas

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Martín Talaverano, Rafael

2014-12-01

Full Text Available The graphic survey of historical buildings is one of the most powerful tools to preserve its material cultural values and it is besides the basis for its research, conservation and dissemination. Although manual drawing has been historically the main representation technique, some other methods have been recently developed to improve the data capture and its later management. This article aims to show clearly the basic concepts related to the making process of the graphic documentation in order to make possible to select reasonably and effectively such techniques. For this purpose, a comparative analysis of the current methods is firstly shown, followed by several case studies and those criteria taken into consideration within them. Finally, the main ideas obtained in the previous analysis are presented, as well as the future prospect that in our opinion set new development ways in this field.La documentación gráfica de edificios históricos constituye una de las herramientas más potentes para la preservación de sus valores culturales materiales y es la base para su investigación, conservación y difusión. Si bien históricamente el dibujo manual ha sido la principal técnica de representación, recientemente se han desarrollado otras para mejorar la toma de datos y su posterior gestión. Este artículo tiene como objetivo mostrar de un modo claro y sencillo los principales conceptos vinculados a la elaboración de la documentación gráfica, para facilitar la selección de las técnicas de un modo razonable y eficaz. Para ello se exponen y comparan los distintos métodos actuales, ofreciendo además varios casos de estudio con los criterios considerados en cada uno de ellos. Como conclusión se describen las ideas fundamentales derivadas de este análisis, así como las perspectivas de futuro que a nuestro juicio abren vías de desarrollo en este campo.

Synthesis of isotopically labelled angiotensin II receptor antagonist GR138950X

International Nuclear Information System (INIS)

Carr, R.M.; Cable, K.M.; Newman, J.J.; Sutherland, D.R.

1996-01-01

Syntheses of [ 13 C] and [ 14 C]-labelled versions of angiotensin II receptor antagonist GR138950X, labelled in the imidazole carboxamide residue, are described. These involved preparation of an iodoimidazole substrate by a novel iododecarboxylation procedure, followed by cyanation with a mixture of carbon-labelled potassium cyanide and copper (l) iodide in DMF at high temperature. The preparation of a mass-labelled (M+5) version of GR138950X is also described. This involved the synthesis of an [ 13 C 3 , 15 N 2 ]-labelled imidazole from a 1,2,3-tricarbonyl compound, [ 13 C 3 ]propionaldehyde and [ 15 N]ammonia. The labelled imidazole was further elaborated into multiply-labelled GR138950X. (Author)

La representación de la diversidad étnica en la publicidad comercial gráfica en España

OpenAIRE

Díez Aguado, Javier

2015-01-01

España es una sociedad cada vez más multiétnica. En este trabajo de fin de grado propongo un breve análisis de la situación de la publicidad española a día de hoy en términos de igualdad y representación de la diversidad étnica. Para ello se realiza un análisis de la representación de las minorías étnicas en una muestra de publicidad gráfica comercial utilizando la metodología del análisis de contenido. También se realiza una revisión de los diferentes códigos de autocontrol que rigen la publ...

Efectividad de la funcionalidad familiar en familias con adolescentes gestantes y adolescentes no gestantes Efetividade da funcionalidade familiar no caso de famílias de adolescentes grávidas e adolescentes não grávidas Effectiveness of family functionality in families with pregnant and non pregnant adolescents

Directory of Open Access Journals (Sweden)

Alexandra García Rueda

2011-07-01

Full Text Available Esta investigación tiene como objetivo comparar la evaluación de la efectividad de la funcionalidad familiar de familias con adolescentes gestantes, y no gestantes, atendidas en la Empresa Social del Estado, Instituto de Salud de Bucaramanga (ESE Isabu, durante el primer semestre de 2009. Es un estudio comparativo, transversal, cuantitativo, realizado con la participación de 77 familias con adolescentes gestantes y 104 familias con adolescentes no gestantes, en las cuales los informantes fueron de cada familia: la adolescente gestante o no gestante, y un familiar que viviera en el mismo hogar de la adolescente participante en el estudio. Para la recolección de la información se utilizó el instrumento ASF-E, de María Luisa Friedemann (1, que mide el nivel de efectividad de la funcionalidad familiar por medio de las dimensiones: cambio, mantenimiento, individuación, coherencia, y las metas: espiritualidad, crecimiento, control, estabilidad del sistema familiar. En los resultados se encontró que las familias con adolescentes gestantes presentan un nivel alto de efectividad de la funcionalidad familiar, referido por las adolescentes gestantes (49,4% y sus familiares (54,5%; mientras que las familias con adolescentes no gestantes presentan un nivel intermedio de efectividad, referido tanto por adolescentes no gestantes como por sus familiares, con igual porcentaje: 57,7%. En conclusión, existen diferencias estadísticamente significativas entre los dos grupos de familias, sobre la efectividad de la funcionalidad familiar, identificada en la prueba T con p: 0,012. Igualmente hay diferencias en las metas de estabilidad (p 0,009 y control (p 0,007 y en las dimensiones de coherencia (p 0,013 y mantenimiento del sistema familiar (p 0,033.Esta pesquisa visa comparar a avaliação da efetividade da funcionalidade familiar das famílias de adolescentes grávidas e não grávidas; atendidas na Empresa Social do Estado Instituto de Saúde de

The Brothers Grimm in The Library of the National Museum of Slovenia: the Legacy of Anastazij Grün

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Urška Pajk

2013-11-01

Full Text Available ABSTRACTThe article is focused on the “treasures” of the National Museum of Slovenia Library a part of them being the books of the count Anton Alexander Auersprg writing under the pseudonym of Anastazij Grün. In 1910 his legacy was included into the museum’s book collection. The poet Anastazij Zelenc was an interesting and unique historical personage and a passionate collector of books and other printed materials. He became especially enthusiastic about antique history and folk literature. Thus, it is not surprising to find the Grimm’s literary “production” in his collection. Anastazij Grün is not sufficiently known in Slovenia. Therefore it is convenient to underline his importance at the occasion of the 150th anniversary of the death of the great fairy tale writer, ethnologist and philologist Jacob Grimm (20th September 2013.

Grænsekrydsende ledelse

DEFF Research Database (Denmark)

Elmholdt, Claus Westergård; Ingerslev, Karen

2013-01-01

interessere sig for, hvordan de tænker, taler og handler på grænser. Ledere er, qua deres organisatoriske position, i særlig grad ansvarlige for at etablere grænsepraktikker, hvor grænser bliver til ’broer’ og ikke ’barrierer’ for samarbejde og innovation. Lykkes det ikke at gøre grænser til udviklingsforkant...

Proinflammatory effect of sodium 4-phenylbutyrate in deltaF508-cystic fibrosis transmembrane conductance regulator lung epithelial cells: involvement of extracellular signal-regulated protein kinase 1/2 and c-Jun-NH2-terminal kinase signaling.

Science.gov (United States)

Roque, Telma; Boncoeur, Emilie; Saint-Criq, Vinciane; Bonvin, Elise; Clement, Annick; Tabary, Olivier; Jacquot, Jacky

2008-09-01

Sodium 4-phenylbutyrate (4-PBA) has attracted a great deal of attention in cystic fibrosis (CF) pathology due to its capacity to traffic DeltaF508-cystic fibrosis transmembrane conductance regulator (CFTR) to the cell membrane and restore CFTR chloride function at the plasma membrane of CF lung cells in vitro and in vivo. Using two different DeltaF508-CFTR lung epithelial cell lines (CFBE41o- and IB3-1 cells, characterized with DeltaF508-homozygous and heterozygous genotype, respectively) in vitro, 4-PBA induced an increase of proinflammatory cytokine interleukin (IL)-8 production in a concentration-dependent manner. This 4-PBA-induced IL-8 production was associated with a strong reduction of proteasome and nuclear factor-kappaB transcriptional activities in the two DeltaF508-CFTR lung cells either in a resting state or after tumor necrosis factor-alpha stimulation. In contrast, a strong increase of activator protein-1 transcriptional activity was observed. The inhibition of extracellular signal-regulated protein kinase 1/2 (ERK1/2) by 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene (U0126) and 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one (PD98059) and c-Jun-NH(2)-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) by anthra[1,9-cd] pyrazol-6 (2H)-one (SP600125), respectively, was associated with a reduction (2-3.5-fold) of IL-8 production in both DeltaF508-CFTR lung cell lines treated with 4-PBA. No significant change of IL-8 production was observed after an inhibition of p38 MAPK with 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl] phenol (SB202190). Therefore, we suggest that inhibition of both ERK1/2 and JNK signaling may be a means to strongly reduce 4-PBA-induced IL-8 production in combination with 4-PBA treatment to restore CFTR Cl(-) channel function in lung epithelial cells of patients with CF.

El humor en la publicidad gráfica de la Dirección General de Tráfico en España (1960-2009

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MA Nicolás Ojeda

2015-12-01

Full Text Available Introducción: El objeto de esta investigación es analizar el humor como modalidad semántica en las campañas publicitarias de la Dirección General de Tráfico de España (DGT e identificar las emociones expresadas en los anuncios que utilizan este recurso. Metodología: Una aproximación metodológica interdisciplinar recoge las investigaciones antecedentes para comprender el estudio del humor como recurso para la elaboración del contenido y la forma de los mensajes publicitarios. Una revisión histórica de la publicidad gráfica de esta institución permite conocer cuándo y cómo el humor ha contribuido a codificar los mensajes publicitarios de la DGT. El universo estudiado está formado por toda la publicidad gráfica de la institución desde el año 1959 al 2009, un total de 246 anuncios. Resultados y conclusiones: Los resultados validan y clasifican la presencia del humor como recurso semántico por décadas estudiadas. A su vez, identifican los objetivos de comunicación de los anuncios analizados y los relaciona con el recurso humorístico utilizado, con los tipos de emociones proyectadas y con el mensaje de cada anuncio.

Sexismo en la publicidad gráfica del siglo XXI

OpenAIRE

Lesmes Fradejas, Yanire

2014-01-01

En la presente investigación se ha tratado el tema de la representación de la mujer estereotipada en la publicidad gráfica del siglo XXI. La publicidad hoy en día sigue teniendo rasgos sexistas y es lo que se ha querido demostrar mediante el análisis de varias gráficas debidamente clasificadas por categorías de productos donde la novedad recae sobre el análisis de publicidad con fines sociales y contra la violencia de género, encontrando en estas también signos de sexismo. Asimismo y bajo la ...

Diminished self-chaperoning activity of the DeltaF508 mutant of CFTR results in protein misfolding.

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Adrian W R Serohijos

2008-02-01

Full Text Available The absence of a functional ATP Binding Cassette (ABC protein called the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR from apical membranes of epithelial cells is responsible for cystic fibrosis (CF. Over 90% of CF patients carry at least one mutant allele with deletion of phenylalanine at position 508 located in the N-terminal nucleotide binding domain (NBD1. Biochemical and cell biological studies show that the DeltaF508 mutant exhibits inefficient biosynthetic maturation and susceptibility to degradation probably due to misfolding of NBD1 and the resultant misassembly of other domains. However, little is known about the direct effect of the Phe508 deletion on the NBD1 folding, which is essential for rational design strategies of cystic fibrosis treatment. Here we show that the deletion of Phe508 alters the folding dynamics and kinetics of NBD1, thus possibly affecting the assembly of the complete CFTR. Using molecular dynamics simulations, we find that meta-stable intermediate states appearing on wild type and mutant folding pathways are populated differently and that their kinetic accessibilities are distinct. The structural basis of the increased misfolding propensity of the DeltaF508 NBD1 mutant is the perturbation of interactions in residue pairs Q493/P574 and F575/F578 found in loop S7-H6. As a proof-of-principle that the S7-H6 loop conformation can modulate the folding kinetics of NBD1, we virtually design rescue mutations in the identified critical interactions to force the S7-H6 loop into the wild type conformation. Two redesigned NBD1-DeltaF508 variants exhibited significantly higher folding probabilities than the original NBD1-DeltaF508, thereby partially rescuing folding ability of the NBD1-DeltaF508 mutant. We propose that these observed defects in folding kinetics of mutant NBD1 may also be modulated by structures separate from the 508 site. The identified structural determinants of increased misfolding propensity of

Desarrollo de una interfaz gráfica, drivers y librerías para hardware de adquisición y generación de señales

OpenAIRE

Bernardino Perez, Daniel

2012-01-01

Projecte realitzat en col·laboració amb Sygnadyne Desarrollo de una interfaz gráfica en C++/Qt, drivers para windows (WDF) y librerías para hardware de adquisición y generación de señales basado en la plataforma PXI.

The novel GrCEP12 peptide from the plant-parasitic nematode Globodera rostochiensis suppresses flg22-mediated PTI.

Science.gov (United States)

Chen, Shiyan; Chronis, Demosthenis; Wang, Xiaohong

2013-09-01

The potato cyst nematode Globodera rostochiensis is a biotrophic pathogen that secretes effector proteins into host root cells to promote successful plant parasitism. In addition to the role in generating within root tissue the feeding cells essential for nematode development, (1) nematode secreted effectors are becoming recognized as suppressors of plant immunity. (2)(-) (4) Recently we reported that the effector ubiquitin carboxyl extension protein (GrUBCEP12) from G. rostochiensis is processed into free ubiquitin and a 12-amino acid GrCEP12 peptide in planta. Transgenic potato lines overexpressing the derived GrCEP12 peptide showed increased susceptibility to G. rostochiensis and to an unrelated bacterial pathogen Streptomyces scabies, suggesting that GrCEP12 has a role in suppressing host basal defense or possibly pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) during the parasitic interaction. (3) To determine if GrCEP12 functions as a PTI suppressor we evaluated whether GrCEP12 suppresses flg22-induced PTI responses in Nicotiana benthamiana. Interestingly, we found that transient expression of GrCEP12 in N. benthamiana leaves suppressed reactive oxygen species (ROS) production and the induction of two PTI marker genes triggered by the bacterial PAMP flg22, providing direct evidence that GrCEP12 indeed has an activity in PTI suppression.

The Oxygen and Nitrogen Abundance of Leo A and GR 8

Science.gov (United States)

van Zee, L.; Skillman, E. D.; Haynes, M. P.

1999-05-01

Gas phase abundances are one of the best measures of the intrinsic metallicity of low mass galaxies. We recently obtained low resolution long slit optical spectra of several HII regions in Leo A and GR 8 with the Palomar 5m telescope. Previous studies of the resolved stellar population of Leo A indicated that the stars have metallicities approximately 2% of solar (Tolstoy et al. 1998). Preliminary analysis of the HII region spectra, and that of a planetary nebula, indicates that the gas phase oxygen abundance of Leo A is approximately 3% of solar. This confirms the result of Skillman et al. (1989), who also derived an oxygen abundance for Leo A from a planetary nebula. Similarly, for GR 8 we find a mean oxygen abundance of 5% of solar. For all the HII regions, the derived log(N/O) is -1.5 +/- 0.1, as has been found for other low metallicity systems. These new observations of multiple HII regions in Leo A and GR 8 confirm that metals in low mass galaxies are well mixed.

Reconocimiento de alimentos vegetales: caracterización micro-gráfica del grano de avena Reconhecimento de alimentos vegetais: caracterização micrográfica do grão de aveia

Directory of Open Access Journals (Sweden)

N.O. Crivaro

2006-06-01

Full Text Available Se estudia la estructura micrográfica del grano de seis variedades de avena con la finalidad de su caracterización, para desarrollar parámetros de identificación en alimentos elaborados con la misma y, consecuentemente, determinar su autenticidad, contribuyendo a optimizar la producción, la comercialización y el consumo del cereal y sus derivados. El diseño experimental consistió en el estudio micrográfico de los granos vestidos y desnudos efectuando un análisis morfológico mediante observación con lupa binocular y fotografía, ultraestructural utilizando microscopio electrónico de barrido, micrográfico y micrométrico, empleando el sistema de video microscopia digitalizado y software adecuado. Dada su variabilidad natural, los estudios se efectuaron durante tres temporadas consecutivas sobre muestras cosechadas de variedades procedentes de cultivos de semillas certificadas, y sobre alimentos procesados (avena arrollada y salvado de avena comerciales. Los resultados consistieron en diseños micrográficos, y en valores micrométricos de gránulos de almidón relacionados, además, en modelos matemáticos. En todos los casos se validó estadísticamente. Como parámetros micrográficos de caracterización se seleccionaron las estructuras diferenciales, que revelaron una presencia constante en el vegetal y resistieron los tratamientos tecnológicos, y las características y dimensiones del almidón.Este trabalho estuda a estrutura micrográfica do grão de seis variedades de aveia com a finalidade de sua caracterização para desenvolver parâmetros de identificação em alimentos elaborados com a mesma e, conseqüentemente, determinar sua genuinidade, contribuindo para otimizar a produção, a comercialização e o consumo do cereal e seus derivados. O experimento consistiu no estudo micrográfico dos grãos com casca e sem casca, efetuando análise morfológica mediante observação com lupa binocular e fotografia ultra

Prevalência da mutação ΔF508 no gene cystic fibrosis transmembrane conductance regulator em pacientes com fibrose cística em um centro de referência no Brasil Prevalence of ΔF508 mutation in the cystic fibrosis transmembrane conductance regulator gene among cystic fibrosis patients from a Brazilian referral center

Directory of Open Access Journals (Sweden)

Andréia Marisa Bieger

2012-12-01

Full Text Available OBJETIVO: Verificar a presença da mutação ΔF508 no gene cystic fibrosis transmembrane conductance regulator na população de pacientes com fibrose cística, diagnosticados pelo teste de sódio e cloro no suor, em acompanhamento no Ambulatório de Pneumologia Pediátrica da Universidade Estadual de Campinas, centro de referência no tratamento da fibrose cística. MÉTODOS: Foram analisadas 167 amostras de DNA de pacientes com fibrose cística. O genótipo dos pacientes foi determinado pela técnica de reação da polimerase e realizado cálculo para a frequência dos alelos e genótipos da mutação ΔF508. RESULTADOS: A frequência genotípica encontrada foi, respectivamente, para os genótipos -/-, ΔF508/- e ΔF508/ΔF508: 43,7% (73 pacientes, 32,9% (55 pacientes e 23,4% (39 pacientes. Do total de 334 alelos analisados, foi observada a frequência de 201 (60,18% alelos para a ausência da mutação ΔF508 e de 133 (39,82% para a presença da mutação ΔF508. O cálculo do equilíbrio de Hardy-Weinberg foi realizado, e obtivemos o valor de qui-quadrado = 16,34 (p OBJECTIVE: To verify the presence of ΔF508 mutation in the cystic fibrosis transmembrane conductance regulator gene among patients with cystic fibrosis diagnosed by the sweat test for sodium and chlorine and followed at the Pediatric Pneumology Outpatient Clinic of Universidade Estadual de Campinas, Brazil, a referral center for the treatment of cystic fibrosis. METHODS: The study analyzed 167 DNA samples from cystic fibrosis patients. Patients' genotype was determined by polymerase chain reaction, and allele and genotype frequencies of ΔF508 mutation were calculated. RESULTS: The genotype frequencies found for -/-, ΔF508/-, and ΔF508/ΔF508 genotypes were respectively: 43.7% (73 patients, 32.9% (55 patients, and 23.4% (39 patients. Of the 334 alleles analyzed, we observed a frequency of 201 (60.18% alleles for the absence of ΔF508 mutation and of 133 (39.82% for the

Capacidad de asimilación de las competencias laborales en la industria de la comunicación gráfica

Directory of Open Access Journals (Sweden)

Luz Alexandra Montoya

2013-03-01

Full Text Available El presente documento expone las principales caracte- rísticas del desarrollo de un estudio exploratorio para la industria de comunicación gráfi ca, en el que se buscó analizar la posibilidad de asimilación de las empresas de un programa de formación, capacitación y evaluación de un sistema de competencias. En primer lugar se defi ne la necesidad de un modelo de competencias para permitir que el sector sea más dinámico y sostenible como un modelo de gestión del talento humano y organizacional, después se exponen las competencias y se formula un modelo de investigación con una muestra de empresas del sector para así determinar cuáles son los requeri- mientos del mismo en el tema.

Interfaz Gráfica de Usuario (GUI) para la Manipulación Interactiva de Imágenes en Aplicaciones Web

OpenAIRE

Luján Vásquez, Renzo

2011-01-01

Desarrollar una aplicación cliente con interfaz gráfica para un software de búsqueda de imágenes de biopsias ópticas, con el propósito de ayudar a endoscopistas a obtener un diagnóstico médico a partir de la manipulación y análisis de imágenes estáticas.

7 CFR 1901.508 - Servicing of insured notes outstanding with investors.

Science.gov (United States)

2010-01-01

... 7 Agriculture 12 2010-01-01 2010-01-01 false Servicing of insured notes outstanding with investors. 1901.508 Section 1901.508 Agriculture Regulations of the Department of Agriculture (Continued) RURAL... Ownership and Insured Notes § 1901.508 Servicing of insured notes outstanding with investors. The Director...

Evaluation of the kappa-opioid receptor-selective tracer [11C]GR103545 in awake rhesus macaques

International Nuclear Information System (INIS)

Schoultz, Bent W.; Hjornevik, Trine; Willoch, Frode; Marton, Janos; Noda, Akihiro; Murakami, Yoshihiro; Miyoshi, Sosuke; Nishimura, Shintaro; Aarstad, Erik; Drzezga, Alexander; Matsunari, Ichiro; Henriksen, Gjermund

2010-01-01

The recent development in radiosynthesis of the 11 C-carbamate function increases the potential of [ 11 C]GR103545, which for the last decade has been regarded as promising for imaging the kappa-opioid receptor (κ-OR) with PET. In the present study, [ 11 C]GR103545 was evaluated in awake rhesus macaques. Separate investigations were performed to clarify the OR subtype selectivity of this compound. Regional brain uptake kinetics of [ 11 C]GR103545 was studied 0-120 min after injection. The binding affinity and opioid subtype selectivity of [ 11 C]GR103545 was determined in cells transfected with cloned human opioid receptors. In vitro binding assays demonstrated a high affinity of GR103545 for κ-OR (K i = 0.02 ±0.01 nM) with excellent selectivity over μ-OR (6 x 10 2 -fold) and δ-OR (2 x 10 4 -fold). PET imaging revealed a volume of distribution (V T ) pattern consistent with the known distribution of κ-OR, with striatum = temporal cortex > cingulate cortex > frontal cortex > parietal cortex > thalamus > cerebellum. [ 11 C]GR103545 is selective for κ-OR and holds promise for use to selectively depict and quantify this receptor in humans by means of PET. (orig.)

Desempenho de cordeiros terminados em confinamento, consumindo silagens de milho de grãos com alta umidade ou grãos de milho hidratados em substituição aos grãos de milho seco da dieta

Directory of Open Access Journals (Sweden)

Reis Wagner dos

2001-01-01

Full Text Available O experimento foi conduzido para avaliar o uso dos grãos de milho em diferentes formas (grãos de milho secos, silagem de grãos de milho hidratado e silagem de grãos de milho úmido sobre o desempenho de cordeiros terminados em confinamento. Foram usados 60 cordeiros (machos e fêmeas, distribuídos aleatoriamente em cinco tratamentos com doze repetições e alimentados com dietas isoprotéicas e isoenergéticas, em diferentes tratamentos: T1 (silagem de grãos de milho hidratados - SMGH, T2 (Grãos de milho seco - GMS, T3 (50% SGMH + 50% GMS, T4 (silagem de grãos de milho úmidos - SGMU e T5 (50% SGMU + 50% GMS. O volumoso utilizado foi feno de aveia. Foram avaliados ganho de peso diário e conversão alimentar aos 28, 56 e 73 dias de confinamento. A dieta com substituição total dos grãos de milho seco por silagem de grãos de milho úmidos apresentou maior ganho de peso aos 73 dias em relação àqueles obtidos aos 56 e 28 dias de confinamento. Este fato pode ser explicado pela melhor digestibilidade apresentada pelas silagens, atribuída à gelatinização que o amido sofre durante o processo. Assim, a silagem de grãos úmidos pode ser usada com eficácia em dietas para cordeiros.

ICC-profilers användbarhetvid gråbalansjusteringav arkoffsettryck

OpenAIRE

Norstedt, Sofia

2003-01-01

I detta examensarbete har gråbalansstyrning och ICC-profilers duglighet undersökts. ICC-profilernahar utvärderats utifrån den tryckkvalitet de genererat tillsammans med olika papper.Gråbalansstyrning har använts som gemensamma likare för samtliga testtryckningar. Detta tillfördeen variabel som var lika för samtliga papper i utredningen. Här med ökade sannolikheten att ICCprofilerskapade från olika papper, skulle ge en likvärdig kvalitet.I arbetet har många mätningar och beräkningar genomförts...

El horizonte gráfico Centelles y su posición en la secuencia del Arte Levantino del Maestrazgo

Directory of Open Access Journals (Sweden)

Valentín VILLAVERDE BONILLA

2009-12-01

Full Text Available RESUMEN: El objetivo central del trabajo es la descripción y valoración de las figuras masculinas y femeninas del horizonte Centelles, prestando una especial atención al tipo de escenas en las que se integran y a su relación con las figuras animales. El Abric de Centelles constituye un foco preferencial de atención, especialmente a la hora de definir la variabilidad formal y compositiva del horizonte. Igualmente, se valoran los elementos que permiten su situación en la secuencia gráfica del núcleo de la Valltorta-Gasulla y se establecen relaciones con otros conjuntos similares del Maestrazgo. Finalmente, se discute la cronología de este horizonte gráfico, considerando una perspectiva territorial.ABSTRACT: The main goal of this paper is the description and appraisal of female and male depictions of the Centelles stylistic horizon, paying special attention to those scenes in which they are integrated and also in their scenic relation with animal depictions. The Centelles rock art shelter is a main focus of attention, especially for defining the formal and compositional variability of this stylistic horizon. In this sense, the elements that allow its situation in the graphic sequence of Valltorta-Gassulla Valley are valued, while stylistic parallels with similar rock art shelters of Maestrazgo area are established. Finally, we discuss the chronology of Centelles stylistic horizon considering a territorial perspective.

31 CFR 594.508 - Transactions related to telecommunications authorized.

Science.gov (United States)

2010-07-01

... telecommunications authorized. 594.508 Section 594.508 Money and Finance: Treasury Regulations Relating to Money and... related to telecommunications authorized. All transactions ordinarily incident to the receipt or transmission of telecommunications involving persons whose property or interests in property are blocked...

31 CFR 545.508 - Transactions related to telecommunications authorized.

Science.gov (United States)

2010-07-01

... telecommunications authorized. 545.508 Section 545.508 Money and Finance: Treasury Regulations Relating to Money and... related to telecommunications authorized. All transactions ordinarily incident to the receipt or transmission of telecommunications involving the territory of Afghanistan controlled by the Taliban are...

Visión por computador e informática gráfica : Realidad virtual, realidad aumentada e interfaces avanzadas

OpenAIRE

Abásolo Guerrero, María José; Mitaritonna, Alejandro; Giacomantone, Javier; De Giusti, Armando Eduardo; Naiouf, Marcelo; Manresa Yee, Cristina; Perales Lopez, Francisco José; Más Sansó, Ramón; Castro, Silvia Mabel

2013-01-01

La línea de investigación y desarrollo presentada consiste en estudiar, desarrollar y evaluar métodos y algoritmos de sistemas de visión por computador así como también de informática gráfica. Los principales temas abordados son reconstrucción 3D, realidad virtual, realidad aumentada e interfaces basadas en visión. Uno de los principales objetivos abordados es el fortalecimiento de la investigación mediante el trabajo intergrupal entre diferentes instituciones, tanto nacionales (Universidad N...

Grøstl Addendum

DEFF Research Database (Denmark)

Gauravaram, Praveen; Knudsen, Lars R.; Matusiewicz, Krystian

2009-01-01

This document is an addendum to the submission document of Grøstl, which was selected for the second round of NIST’s SHA-3 competition [18]. We stress that we do not change the specification of Grøstl. In other words, Grøstl is defined exactly as specified in the original submission document [8]....

Regard sur Le Temps des grâces, de Dominique Marchais A look at Le temps des grâces by Dominique Marchais Una mirada a Le temps des grâces, de Dominique Marchais

Directory of Open Access Journals (Sweden)

Christèle Dondeyne

2013-03-01

Full Text Available Le documentaire Le Temps des grâces de Dominique Marchais s’attache aux regards que des agriculteurs de différentes générations portent sur leur activité et aux analyses d’agronomes et d’économistes sur l’agriculture française. Il donne à voir quelques unes des multiples façons dont le travail agricole modèle les paysages et les écosystèmes et souligne le poids des politiques publiques dans ces orientations. Son constat global laisse plus de place à une industrialisation de l’agriculture qui conduit à l’uniformisation des produits et à la mort des sols qu’à des alternatives viables pour les écosystèmes. La confrontation de ce documentaire avec des travaux majeurs de la sociologie sur ce thème produit une impression de décalage et renvoie à des réflexions théoriques et méthodologiques.Dominique Marchais’ documentary, Le Temps des grâces, deals with different farmer generations’ vision of their work. It also provides an agronomic and economic analysis of French farming, showing some of the many different ways in which agricultural activity shapes landscape and ecosystems, while stressing the responsibility of public policy in such processes. The general observation highlights the growing industrialisation of agriculture, leading more to the uniformisation of products and destruction of soil fertility than to ecologically viable alternatives. When compared with major sociological studies in this area, the documentary highlights certain deviations while referring to theoretical and methodological thinking in this domain.En su documental Le Temps des grâces, Dominique Marchais se interesa en la visión que agricultores de diferentes generaciones tienen de su quehacer y en algunos análisis de la agricultura francesa realizados por agrónomos y economistas. Su trabajo permite vislumbrar algunas de las múltiples formas en que el trabajo agrícola modela los paisajes y los ecosistemas, y hace hincapié en el

Grønne, kommunale regnskaber

DEFF Research Database (Denmark)

Kristiansen, K.

Hvad er et grønt, kommunalt regnskab? Hvordan får man miljøhjulet til at dreje? Hvorfor lave et grønt regnskab? Håndbog i grønne, kommunale regnskaber viser, hvordan man nemt kan lave et grønt regnskab, som er tilpasset forholdene i den enkelte kommune og som kan bruges i det lokale Agenda 21...

Synthesis and Crystal Structure of Di-μ-chlorido-bis{chlorido[4-ethyl- N-(pyridin-2-ylmethylidene-κ N)aniline-κ N]mercury(II)}

Science.gov (United States)

Khalaj, M.; Seftejani, F. B.; Ghazanfarpour-Darjani, M.; Lalegani, A.

2017-12-01

The centrosymmetric dinuclear title complex [Hg2Cl4(dip)2] was synthesized using the Schiff base bidentate ligand (E)-4-ethyl- N-(pyridine-2-ylmethylene)benzeneamine ( dip) and mercury(II) chloride salts. It has been characterized by elemental analysis, X-ray diffraction, and UV-Visible and infrared spectroscopic techniques. The X-ray analysis shows that the title compound crystallizes in the monoclinic sp. gr. P21/n, Z = 2 with a = 7.8233(17) Å, b = 15.178(3) Å, c = 12.559(3) Å, β = 97.021(3)°. The Hg(II) ion has a distorted trigonal-bipyramidal coordination environment formed by the bischelating N-heterocyclic ligands, two bridging Cl atoms and one terminal Cl atom.

Desarrollo de un modelo de gestión de la inteligencia organizacional para la compañía Gráficas Modernas S.A.

Directory of Open Access Journals (Sweden)

Jonathan Lozano Oviedo

2016-02-01

Full Text Available La inteligencia organizacional (io es un tema que ha sido investigado desde la literatura administrativa, lo que es interesante para el contexto organizacional, dadas las implicaciones que una mejora de la io puede tener en el éxito, la conservación en el tiempo y el desarrollo de una compañía. Este artículo incorpora los resultados de una investigación sobre la io realizada en el contexto de la compañía Gráficas Modernas S.A. El presente trabajo se propuso desarrollar un modelo de gestión de la io para esta empresa.

Calores de Solución y Propiedades Termodinámicas Relacionadas: Un método Gráfico General de Cálculo

Directory of Open Access Journals (Sweden)

Alfredo Gómez O.

2009-07-01

Full Text Available Se presenta un método gráfico de cálculo con el cual es posible evaluar a partir de datos de calor de solución. diferentes propiedades termodinámicas de interés tales como: caloresres diferenciales de solución del soluto y del solvente. A HD,P 2 V ^ HOIF.I • calor de solución a dilución infinita A tH°; entalpias molares parciales relativas del soluto y del solvente. Lj y L,. y la entalpia molar aparente relativa, L^. El método está basado en la representación gráfica del calor integral de solución expresado por mol de soluto, A H||,fr.2 en función de la relación entre el número de moles de solvente y soluto, n^/nj. Cuando k>s datos experimentales de calor de solución son tomados hasta alta dilución, puede obtenerse con precisión el vak>r de A H°, con to cual el diagrama propuesto corresponde también a la representación gráfica de(^L2 en función de n^/nj. Se discute el significado f fsk» de las propiedades consideradas así como las relaciones existentes entre ellas. El diagrama propuesto presenta ventajas ya que además de su carácter más general, resulta más preciso y conveniente que k>s métodos particulares comúnmente empleados, especialmente en la evaluación de las propiedades citadas para el caso del soluto en soluciones muy diluidas. de(^L2 en función de n^/nj. Se discute el signifteado f fsk» de las propiedades conskJeradas asi como las relaciones existentes entre ellas. El diagrama propuesto presenta ventajéis ya que además de su caráctermás general, resulta más preciso y conveniente que k>s métodos particulares comúnmente empleados, especialmente en la evaluackin de las propiedades citadas para el caso del soluto en soluctones muy diluidas.

Computing Gröbner fans

DEFF Research Database (Denmark)

Fukuda, K.; Jensen, Anders Nedergaard; Thomas, R.R.

2005-01-01

This paper presents algorithms for computing the Gröbner fan of an arbitrary polynomial ideal. The computation involves enumeration of all reduced Gröbner bases of the ideal. Our algorithms are based on a uniform definition of the Gröbner fan that applies to both homogeneous and non......-homogeneous ideals and a proof that this object is a polyhedral complex. We show that the cells of a Gröbner fan can easily be oriented acyclically and with a unique sink, allowing their enumeration by the memory-less reverse search procedure. The significance of this follows from the fact that Gröbner fans...... are not always normal fans of polyhedra in which case reverse search applies automatically. Computational results using our implementation of these algorithms in the software package Gfan are included....

41 CFR 101-26.508-3 - Consolidation of requisitions.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Consolidation of requisitions. 101-26.508-3 Section 101-26.508-3 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT...

Desarrollo de una interfaz gráfica para un sistema electrónico de caracterización óptica de diodos emisores de luz

OpenAIRE

Colino Barrigón, Juan José

2015-01-01

En este Trabajo de Fin de Grado (TFG) se describe el proceso de análisis, diseño y desarrollo de una interfaz gráfica para un sistema de caracterización óptica de diodos emisores de luz (LED del inglés Light-emitting diode). La interfaz ha sido implementada en Python usando la librería gráfica GTK+3 para Linux. Grado en Ingeniería Informática

CRTC2 Is a Coactivator of GR and Couples GR and CREB in the Regulation of Hepatic Gluconeogenesis.

Science.gov (United States)

Hill, Micah J; Suzuki, Shigeru; Segars, James H; Kino, Tomoshige

2016-01-01

Glucocorticoid hormones play essential roles in the regulation of gluconeogenesis in the liver, an adaptive response that is required for the maintenance of circulating glucose levels during fasting. Glucocorticoids do this by cooperating with glucagon, which is secreted from pancreatic islets to activate the cAMP-signaling pathway in hepatocytes. The cAMP-response element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) is a coactivator known to be specific to CREB and plays a central role in the glucagon-mediated activation of gluconeogenesis in the early phase of fasting. We show here that CRTC2 also functions as a coactivator for the glucocorticoid receptor (GR). CRTC2 strongly enhances GR-induced transcriptional activity of glucocorticoid-responsive genes. CRTC2 physically interacts with the ligand-binding domain of the GR through a region spanning amino acids 561-693. Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB. CRTC2 is required for the maintenance of blood glucose levels during fasting in mice by enhancing the GR transcriptional activity on both the G6p and phosphoenolpyruvate carboxykinase (Pepck) genes. Finally, CRTC2 modulates the transcriptional activity of the progesterone receptor, indicating that it may influence the transcriptional activity of other steroid/nuclear receptors. Taken together, these results reveal that CRTC2 plays an essential role in the regulation of hepatic gluconeogenesis through coordinated regulation of the glucocorticoid/GR- and glucagon/CREB-signaling pathways on the key genes G6P and PEPCK.

Evaluation of the kappa-opioid receptor-selective tracer [{sup 11}C]GR103545 in awake rhesus macaques

Energy Technology Data Exchange (ETDEWEB)

Schoultz, Bent W. [University of Oslo, Department of Chemistry, Oslo (Norway); Hjornevik, Trine; Willoch, Frode [University of Oslo, Centre for Molecular Biology and Neuroscience and Institute of Basic Medical Sciences, Oslo (Norway); Akershus University Hospital, Department of Nuclear Medicine, Loerenskog (Norway); Marton, Janos [ABX Advanced Biochemical Compounds GmbH, Radeberg (Germany); Noda, Akihiro; Murakami, Yoshihiro; Miyoshi, Sosuke; Nishimura, Shintaro [Medical and Pharmacological Research Center Foundation, Basic Research Department, Hakui City, Ishikawa (Japan); Aarstad, Erik [University College of London, Institute of Nuclear Medicine, London (United Kingdom); Drzezga, Alexander [Technische Universitaet Muenchen, Department of Nuclear Medicine, Klinikum rechts der Isar, Munich (Germany); Matsunari, Ichiro [Medical and Pharmacological Research Center Foundation, Clinical Research Department, Hakui City, Ishikawa (Japan); Henriksen, Gjermund [University of Oslo, Department of Chemistry, Oslo (Norway); Technische Universitaet Muenchen, Department of Nuclear Medicine, Klinikum rechts der Isar, Munich (Germany)

2010-06-15

The recent development in radiosynthesis of the {sup 11}C-carbamate function increases the potential of [{sup 11}C]GR103545, which for the last decade has been regarded as promising for imaging the kappa-opioid receptor ({kappa}-OR) with PET. In the present study, [{sup 11}C]GR103545 was evaluated in awake rhesus macaques. Separate investigations were performed to clarify the OR subtype selectivity of this compound. Regional brain uptake kinetics of [{sup 11}C]GR103545 was studied 0-120 min after injection. The binding affinity and opioid subtype selectivity of [{sup 11}C]GR103545 was determined in cells transfected with cloned human opioid receptors. In vitro binding assays demonstrated a high affinity of GR103545 for {kappa}-OR (K{sub i} = 0.02 {+-}0.01 nM) with excellent selectivity over {mu}-OR (6 x 10{sup 2}-fold) and {delta}-OR (2 x 10{sup 4}-fold). PET imaging revealed a volume of distribution (V{sub T}) pattern consistent with the known distribution of {kappa}-OR, with striatum = temporal cortex > cingulate cortex > frontal cortex > parietal cortex > thalamus > cerebellum. [{sup 11}C]GR103545 is selective for {kappa}-OR and holds promise for use to selectively depict and quantify this receptor in humans by means of PET. (orig.)

48 CFR 9.508 - Examples.

Science.gov (United States)

2010-10-01

... CONTRACTOR QUALIFICATIONS Organizational and Consultant Conflicts of Interest 9.508 Examples. The examples in paragraphs (a) through (i) following illustrate situations in which questions concerning organizational... (e.g., fire control, navigation, etc.). In this example, the system is the powerplant, not the...

Hjemløshed i Grønland

DEFF Research Database (Denmark)

Hansen, Knud Erik; Andersen, Hans Thor

Rapporten giver en beskrivelse af karakteren af hjemløsheden i Grønland. Den beskriver forholdene for tre måder at være ude i hjemløshed på i Grønland, hvordan husstande når dertil og hvilke muligheder de har for at komme ud af hjemløsheden. I rapporten indgår beskrivelser af en række personers liv...... households get homeless and their options to get out of homelessness. The report contains descriptions of how a number of people live in homelessness. The three types are: Homeless with no fixed accommodation, resettled living in resettlement housing and homeless who are long-time living with family, friends...

Radiosynthesis and radiopharmacological evaluation of [N-methyl-11C]Org 34850 as a glucocorticoid receptor (GR)-binding radiotracer

International Nuclear Information System (INIS)

Wuest, Frank; Kniess, Torsten; Henry, Brian; Peeters, Bernardus W.M.M.; Wiegerinck, Peter H.G.; Pietzsch, Jens; Bergmann, Ralf

2009-01-01

The radiosynthesis of [N-methyl- 11 C]Org 34850 as a potential brain glucocorticoid receptor (GR)-binding radiotracer is described. The radiosynthesis was accomplished via N-methylation of the corresponding desmethyl precursor with [ 11 C]methyl triflate in a remotely controlled synthesis module to give the desired compound in a radiochemical yield of 23±5% (decay-corrected, based upon [ 11 C]CO 2 ) at a specific activity of 47±12 GBq/μmol (n=15) at the end-of-synthesis (EOS). The radiochemical purity after semi-preparative HPLC purification exceeded 95%. The total synthesis time was 35-40 min after end-of-bombardment (EOB). The radiotracer is rapidly metabolized in rat plasma leading to the formation of two more hydrophilic metabolites as the major metabolites. Radiopharmacological evaluation involving biodistribution and small animal PET imaging in normal Wistar rats showed that the compound [N-methyl- 11 C]Org 34850 is not able to sufficiently penetrate the blood-brain barrier. Therefore, compound [N-methyl- 11 C]Org 34850 seems not to be a suitable PET radiotracer for imaging rat brain GRs. However, involvement of Pgp or species differences requires further clarification to establish whether the radiotracer [N-methyl- 11 C]Org 34850 may still represent a suitable candidate for imaging GRs in humans

Radiosynthesis and radiopharmacological evaluation of [N-methyl-11C]Org 34850 as a glucocorticoid receptor (GR)-binding radiotracer.

Science.gov (United States)

Wuest, Frank; Kniess, Torsten; Henry, Brian; Peeters, Bernardus W M M; Wiegerinck, Peter H G; Pietzsch, Jens; Bergmann, Ralf

2009-02-01

The radiosynthesis of [N-methyl-(11)C]Org 34850 as a potential brain glucocorticoid receptor (GR)-binding radiotracer is described. The radiosynthesis was accomplished via N-methylation of the corresponding desmethyl precursor with [(11)C]methyl triflate in a remotely controlled synthesis module to give the desired compound in a radiochemical yield of 23+/-5% (decay-corrected, based upon [(11)C]CO(2)) at a specific activity of 47+/-12 GBq/micromol (n=15) at the end-of-synthesis (EOS). The radiochemical purity after semi-preparative HPLC purification exceeded 95%. The total synthesis time was 35-40 min after end-of-bombardment (EOB). The radiotracer is rapidly metabolized in rat plasma leading to the formation of two more hydrophilic metabolites as the major metabolites. Radiopharmacological evaluation involving biodistribution and small animal PET imaging in normal Wistar rats showed that the compound [N-methyl-(11)C]Org 34850 is not able to sufficiently penetrate the blood-brain barrier. Therefore, compound [N-methyl-(11)C]Org 34850 seems not to be a suitable PET radiotracer for imaging rat brain GRs. However, involvement of Pgp or species differences requires further clarification to establish whether the radiotracer [N-methyl-(11)C]Org 34850 may still represent a suitable candidate for imaging GRs in humans.

Desempenho agronômico de trigo cultivado para grãos e duplo propósito em sistemas de integração lavoura-pecuária

Directory of Open Access Journals (Sweden)

Henrique Pereira dos Santos

2011-10-01

Full Text Available O objetivo deste trabalho foi avaliar a produtividade e os componentes de produção de trigo cultivado para grãos e duplo propósito em sistemas de integração lavoura-pecuária (ILP, em plantio direto. A produtividade de grãos dos dois tipos de trigo e os componentes de produção do trigo para produção de grãos foram avaliados nos anos agrícolas de 2003 a 2008, em um Latossolo Vermelho distrófico típico, em Coxilha, RS, nos sistemas de rotação: 1, trigo/soja e ervilhaca/milho; 2, trigo/soja e pastagem de aveia-preta/milho; 3, trigo/soja e pastagem de aveia-preta/soja; 4, trigo/soja e ervilha/milho; 5, trigo/soja, triticale de duplo propósito/soja e ervilhaca/soja; e 6, trigo/soja, aveia-branca de duplo propósito/soja e trigo de duplo propósito/soja. Utilizou-se o delineamento de blocos ao acaso, com quatro repetições. Não houve diferença entre as médias dos componentes de produção (número de espigas, número de grãos por espiga e massa de grãos do trigo para produção de grãos, nos diferentes sistemas ILP. Os sistemas 2, 3, 4 e 5 proporcionaram maior produtividade do trigo para grãos em comparação ao 6. Não há diferença significativa na produtividade de grãos, na massa hectolítrica e na massa de mil grãos, entre os trigos cultivados para produção de grãos e para duplo propósito.

Traducir la subversión. Análisis queer de las versiones italiana y española de la novela gráfica Fun Home de Alison Bechdel

OpenAIRE

Nestore, Angelo

2015-01-01

El objetivo de la tesis Traducir la subversión es aplicar las Teorías Queer al análisis de la traducción de la novela gráfica, a través de un estudio descriptivo de las versiones italiana (de Martina Recchiuti) y castellana (de Rocío de la Maya) de la novela gráfica Fun Home de Alison Bechdel, publicada en EE.UU. en 2006 y galardonada con numerosos premios literarios. Se analiza cómo y en qué medida la traducción puede operar, o no, como factor de cambio al servicio de la subversión de las id...

Interfície gràfica per WPKG - distribució de programari

OpenAIRE

Garcia Morant, Josep

2012-01-01

Interfície gràfica per a la gestió del programari de lliure accés per a la distribució de programari WPKG (wpkg.org). Arquitectura MVC en un entorn J2EE6 utilitzant JSF2, JPA2 i EJB 3.1. Interfaz gráfica para la gestión del software de libre acceso para la distribución de software WPKG (wpkg.org). Arquitectura MVC en un entorno J2EE6 utilizando JSF2, JPA2 y EJB 3.1.

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect.

Directory of Open Access Journals (Sweden)

Guido Veit

2016-05-01

Full Text Available The most common cystic fibrosis (CF causing mutation, deletion of phenylalanine 508 (ΔF508 or Phe508del, results in functional expression defect of the CF transmembrane conductance regulator (CFTR at the apical plasma membrane (PM of secretory epithelia, which is attributed to the degradation of the misfolded channel at the endoplasmic reticulum (ER. Deletion of phenylalanine 670 (ΔF670 in the yeast oligomycin resistance 1 gene (YOR1, an ABC transporter of Saccharomyces cerevisiae phenocopies the ΔF508-CFTR folding and trafficking defects. Genome-wide phenotypic (phenomic analysis of the Yor1-ΔF670 biogenesis identified several modifier genes of mRNA processing and translation, which conferred oligomycin resistance to yeast. Silencing of orthologues of these candidate genes enhanced the ΔF508-CFTR functional expression at the apical PM in human CF bronchial epithelia. Although knockdown of RPL12, a component of the ribosomal stalk, attenuated the translational elongation rate, it increased the folding efficiency as well as the conformational stability of the ΔF508-CFTR, manifesting in 3-fold augmented PM density and function of the mutant. Combination of RPL12 knockdown with the corrector drug, VX-809 (lumacaftor restored the mutant function to ~50% of the wild-type channel in primary CFTRΔF508/ΔF508 human bronchial epithelia. These results and the observation that silencing of other ribosomal stalk proteins partially rescue the loss-of-function phenotype of ΔF508-CFTR suggest that the ribosomal stalk modulates the folding efficiency of the mutant and is a potential therapeutic target for correction of the ΔF508-CFTR folding defect.

Microstructure of a safe-end dissimilar metal weld joint (SA508-52-316L) prepared by narrow-gap GTAW

Energy Technology Data Exchange (ETDEWEB)

Ming, Hongliang [Key Laboratory of Nuclear Materials and Safety Assessment, Liaoning Key Laboratory for Safety and Assessment Technique of Nuclear Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049 (China); Zhang, Zhiming [Key Laboratory of Nuclear Materials and Safety Assessment, Liaoning Key Laboratory for Safety and Assessment Technique of Nuclear Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Wang, Jianqiu, E-mail: wangjianqiu@imr.ac.cn [Key Laboratory of Nuclear Materials and Safety Assessment, Liaoning Key Laboratory for Safety and Assessment Technique of Nuclear Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Han, En-Hou [Key Laboratory of Nuclear Materials and Safety Assessment, Liaoning Key Laboratory for Safety and Assessment Technique of Nuclear Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Wang, Peipei; Sun, Zhiyuan [Shanghai Research Center for Weld and Detection Engineering Technique of Nuclear Equipment, Shanghai 201306 (China)

2017-01-15

The microstructure, residual strain and interfacial chemical composition distribution of a safe-end dissimilar metal weld joint (DMWJ, SA508-52-316L) prepared by narrow-gap gas-tungsten arc welding (NG-GTAW) were studied by optical microscope (OM) and scanning electron microscope equipped with an energy dispersive X-ray microanalysis (SEM/EDX) and an electron back scattering diffraction (EBSD) system. Complex microstructure and chemical composition distribution are found, especially at the SA508-52 interface and the 52-316L interface. In brief, a complicated microstructure transition exists within the SA508 heat affected zone (HAZ); the residual strain, the fraction of high angle random grain boundaries and low angle boundaries decrease with increasing the distance from the fusion boundary in 316L HAZ; neither typical type II boundary nor obvious carbon-depleted zone is found near the SA508-52 interface; dramatic and complicated changes of the contents of the main elements, Fe, Cr and Ni, are observed at the distinct interfaces, especially at the SA508-52 interface. No carbon concentration is found at the SA508-52 interface. - Highlights: •Residual strain and GBCD change as a function of the distance from FB in 316L HAZ. •Neither type II boundary nor obvious carbon-depleted zone is found in SA508 HAZ. •No carbon concentration is found at the SA508-52 interface. •The middle part of the DMWJ has the highest residual strain.

TP508 accelerates fracture repair by promoting cell growth over cell death

International Nuclear Information System (INIS)

Li Xinmin; Wang Hali; Touma, Edward; Qi Yuchen; Rousseau, Emma; Quigg, Richard J.; Ryaby, James T.

2007-01-01

TP508 is a synthetic 23-amino acid peptide representing a receptor-binding domain of human thrombin. We have previously shown that a single injection of TP508 accelerates fracture healing in a rat femoral fracture model. To understand how TP508 acts at the protein level during fracture healing, we compared the translational profiles between saline-control and fractured femur at six time points after TP508 treatment using the second generation of BD Clontech TM Antibody Microarray. Here, we demonstrate that TP508 accelerates fracture healing by modulating expression levels of proteins primarily involved in the functional categories of cell cycle, cellular growth and proliferation, and cell death. The majority of those proteins are physically interrelated and functionally overlapped. The action of those proteins is highlighted by a central theme of promoting cell growth via balance of cell survival over cell death signals. This appears to occur through the stimulation of several bone healing pathways including cell cycle-G1/S checkpoint regulation, apoptosis, JAK/STAT, NF-κB, PDGF, PI3K/AKT, PTEN, and ERK/MAPK

Frukt og grønt i mat og helsefaget. En casestudie

OpenAIRE

Kristoffersen, Mirjam

2016-01-01

Masteroppgave i fysisk aktivitet og kosthold i et skolemiljø Bakgrunn og hensikt: Studier viser at barn og unge har et for lavt inntak av frukt og grønt i forhold til hva som er anbefalt. Skolen er en arena hvor en kan nå mange med kunnskap om hvorfor en bør spise mer frukt og grønnsaker. Spesielt faget mat og helse kan bidra til å belyse temaet gjennom undervisningen. Hensikten med denne studien er å bidra med kunnskap om hva som blir brukt av frukt og grønnsaker og hvordan det blir benyt...

30 CFR 77.508-1 - Lightning arresters; wires entering buildings.

Science.gov (United States)

2010-07-01

.... 77.508-1 Section 77.508-1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS, SURFACE COAL MINES AND SURFACE WORK AREAS... buildings. Lightning arresters protecting exposed telephone wires entering buildings shall be provided at...

Relación de los ambientes hipertextuales de aprendizaje gráfico y sonoro, con los estilos de aprendizaje verbal y visual

OpenAIRE

CARO., EDGAR O.; MONROY F., MARIAN

2009-01-01

Esta investigación se enfocó a detallar la experimentación llevada a cabo para determinar las diferencias entre dos ambientes computacionales e hipertextuales, un ambiente rico en información gráfica (formatos: bmp, jpg, gif ) y el otro ambiente rico en información sonora (formatos: Wave, Mp3, Midi), y donde se presenta información que conceptualiza el diseño de redes de transmisión de datos de área local , con dos grupos de estudiantes que previamente se les ha identificado el estilo de apre...

20 CFR 404.508 - Defeat the purpose of Title II.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Defeat the purpose of Title II. 404.508 Section 404.508 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND... and necessary expenses include: (1) Fixed living expenses, such as food and clothing, rent, mortgage...

La Enseñanza del álgebra Lineal Utilizando Modelización y Calculadora Gráfica: un Estudio con Profesores en Formación (Using Modelling and Graphic Calculators in the Teaching of Linear Algebra: A Study in a Teacher Training Program

Directory of Open Access Journals (Sweden)

José Ortíz

2008-06-01

Full Text Available Exploramos el conocimiento didáctico desarrollado por diez futuros profesores de matemáticas de secundaria que participaron en un programa de formación que integra, a través del álgebra lineal, el uso de la calculadora gráfica y la modelización matemática. Utilizamos una aproximación cualitativa. El análisis de las actividades de enseñanza diseñadas por los participantes que involucran la calculadora gráfica y la modelización muestra cambios y progreso en su conocimiento didáctico. We explored the didactical knowledge developed by ten secondary mathematics teachers who participated in a training program that involved the graphing calculator and modeling on linear algebra topics. We used a qualitative approach. The analysis of the algebra teaching activities designed by the participants involving the graphing calculator and modeling shows changes and progress in their didactical knowledge.

Cystic fibrosis Delta F508 heterozygotes, smoking, and reproduction

DEFF Research Database (Denmark)

Dahl, Morten; Tybjaerg-Hansen, A; Wittrup, H H

1998-01-01

Cystic fibrosis is the most common fatal autosomal recessive disease affecting Caucasian populations. It remains a puzzle how this disease is maintained at such a remarkably high incidence, however, it could be due to a reproductive advantage in cystic fibrosis heterozygotes. We tested this hypot......Cystic fibrosis is the most common fatal autosomal recessive disease affecting Caucasian populations. It remains a puzzle how this disease is maintained at such a remarkably high incidence, however, it could be due to a reproductive advantage in cystic fibrosis heterozygotes. We tested.......001). In conclusion, overall these results do not support a reproductive advantage for cystic fibrosis DeltaF508 heterozygotes. However, the data cannot totally exclude the possibility that nonsmoking DeltaF508 heterozygotes experience a reproductive advantage while smoking DeltaF508 heterozygotes experience...... the opposite, a reproductive disadvantage. Accordingly, the data suggest a previously undocumented role of smoking on fecundity among cystic fibrosis heterozygotes....

24 CFR 5.508 - Submission of evidence of citizenship or eligible immigration status.

Science.gov (United States)

2010-04-01

... citizenship or eligible immigration status. 5.508 Section 5.508 Housing and Urban Development Office of the... Restrictions on Assistance to Noncitizens § 5.508 Submission of evidence of citizenship or eligible immigration... or eligible immigration status, the family members may exercise the election not to contend to have...

Estudio de gráficos estadísticos usados en una muestra de libros de matemáticas para la educación básica y media en Bogotá

OpenAIRE

Mateus , Leidy

2014-01-01

A continuación se expone un ejemplo del estudio de los gráficos estadísticos que aparecen en una muestra de 5 libros de matemáticas, diseñados para la enseñanza en la educación básica y media y publicados en los últimos 50 años en Bogotá. Inicialmente con 1.013 libros revisados y mediante criterios de reducción, organización y sistematización de la información, nos brinda una muestra significativa por décadas de 5 libros. Con relación a los gráficos de la muestra de libros, se elaboró un cont...

From Schottky to Ohmic graphene contacts to AlGaN/GaN heterostructures: Role of the AlGaN layer microstructure

International Nuclear Information System (INIS)

Fisichella, G.; Greco, G.; Roccaforte, F.; Giannazzo, F.

2014-01-01

The electrical behaviour of graphene (Gr) contacts to Al x Ga 1−x N/GaN heterostructures has been investigated, focusing, in particular, on the impact of the AlGaN microstructure on the current transport at Gr/AlGaN interface. Two Al 0.25 Ga 0.75 N/GaN heterostructures with very different quality in terms of surface roughness and defectivity, as evaluated by atomic force microscopy (AFM) and transmission electron microscopy, were compared in this study, i.e., a uniform and defect-free sample and a sample with a high density of typical V-defects, which locally cause a reduction of the AlGaN thickness. Nanoscale resolution current voltage (I-V) measurements by an Au coated conductive AFM tip were carried out at several positions both on the bare and Gr-coated AlGaN surfaces. Rectifying contacts were found onto both bare AlGaN surfaces, but with a more inhomogeneous and lower Schottky barrier height (Φ B  ≈ 0.6 eV) for AlGaN with V-defects, with respect to the case of the uniform AlGaN (Φ B  ≈ 0.9 eV). Instead, very different electrical behaviours were observed in the presence of the Gr interlayer between the Au tip and AlGaN, i.e., a Schottky contact with reduced barrier height (Φ B ≈ 0.4 eV) for the uniform AlGaN and an Ohmic contact for the AlGaN with V-defects. Interestingly, excellent lateral uniformity of the local I-V characteristics was found in both cases and can be ascribed to an averaging effect of the Gr electrode over the AlGaN interfacial inhomogeneities. Due to the locally reduced AlGaN layer thickness, V defect act as preferential current paths from Gr to the 2DEG and can account for the peculiar Ohmic behaviour of Gr contacts on defective AlGaN

19 CFR 351.508 - Debt forgiveness.

Science.gov (United States)

2010-04-01

... Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Identification and Measurement of Countervailable Subsidies § 351.508 Debt forgiveness. (a) Benefit. In the case of an assumption or forgiveness of a firm's debt obligation, a benefit exists equal to the amount of...

Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis.

Science.gov (United States)

Esposito, Speranza; Tosco, Antonella; Villella, Valeria R; Raia, Valeria; Kroemer, Guido; Maiuri, Luigi

2016-12-01

Cystic fibrosis (CF) is a lethal monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that entails the (diagnostic) increase in sweat electrolyte concentrations, progressive lung disease with chronic inflammation and recurrent bacterial infections, pancreatic insufficiency, and male infertility. Therapies aimed at restoring the CFTR defect have emerged. Thus, a small molecule which facilitates chloride channel opening, the potentiator Ivacaftor, has been approved for the treatment of CF patients bearing a particular class of rare CFTR mutations. However, small molecules that directly target the most common misfolded CFTR mutant, F508del, and improve its intracellular trafficking in vitro, have been less effective than expected when tested in CF patients, even in combination with Ivacaftor. Thus, new strategies are required to circumvent the F508del-CFTR defect. Airway and intestinal epithelial cells from CF patients bearing the F508del-CFTR mutation exhibit an impressive derangement of cellular proteostasis, with oxidative stress, overactivation of the tissue transglutaminase (TG2), and disabled autophagy. Proteostasis regulators such as cysteamine can rescue and stabilize a functional F508del-CFTR protein through suppressing TG2 activation and restoring autophagy in vivo in F508del-CFTR homozygous mice, in vitro in CF patient-derived cell lines, ex vivo in freshly collected primary patient's nasal cells, as well as in a pilot clinical trial involving homozygous F508del-CFTR patients. Here, we discuss how the therapeutic normalization of defective proteostasis can be harnessed for the treatment of CF patients with the F508del-CFTR mutation.

SiglecF+Gr1hi eosinophils are a distinct subpopulation within the lungs of allergen-challenged mice.

Science.gov (United States)

Percopo, Caroline M; Brenner, Todd A; Ma, Michelle; Kraemer, Laura S; Hakeem, Reem M A; Lee, James J; Rosenberg, Helene F

2017-01-01

Although eosinophils as a group are readily identified by their unique morphology and staining properties, flow cytometry provides an important means for identification of subgroups based on differential expression of distinct surface Ags. Here, we characterize an eosinophil subpopulation defined by high levels of expression of the neutrophil Ag Gr1 (CD45 + CD11c - SiglecF + Gr1 hi ). SiglecF + Gr1 hi eosinophils, distinct from the canonical SiglecF + Gr1 - eosinophil population, were detected in allergen-challenged wild-type and granule protein-deficient (EPX -/- and MBP-1 -/- ) mice, but not in the eosinophil-deficient ΔdblGATA strain. In contrast to Gr1 + neutrophils, which express both cross-reacting Ags Ly6C and Ly6G, SiglecF + Gr1 hi eosinophils from allergen-challenged lung tissue are uniquely Ly6G + Although indistinguishable from the more-numerous SiglecF + Gr1 - eosinophils under light microscopy, FACS-isolated populations revealed prominent differences in cytokine contents. The lymphocyte-targeting cytokines CXCL13 and IL-27 were identified only in the SiglecF + Gr1 hi eosinophil population (at 3.9 and 4.8 pg/10 6 cells, respectively), as was the prominent proinflammatory mediator IL-13 (72 pg/10 6 cells). Interestingly, bone marrow-derived (SiglecF + ), cultured eosinophils include a more substantial Gr1 + subpopulation (∼50%); Gr1 + bmEos includes primarily a single Ly6C + and a smaller, double-positive (Ly6C + Ly6G + ) population. Taken together, our findings characterize a distinct SiglecF + Gr1 hi eosinophil subset in lungs of allergen-challenged, wild-type and granule protein-deficient mice. SiglecF + Gr1 hi eosinophils from wild-type mice maintain a distinct subset of cytokines, including those active on B and T lymphocytes. These cytokines may facilitate eosinophil-mediated immunomodulatory responses in the allergen-challenged lung as well as in other distinct microenvironments. © Society for Leukocyte Biology.

Caracterización de los sistemas de calidad del sector de las artes gráficas impresas en las pymes colombianas

OpenAIRE

2010-01-01

Esta investigación identifica, analiza y contextualiza los sistemas de calidad que se manejan en las Pymes del sector de las artes gráficas impresas, se realizó un diagnóstico sobre la calidad en el sector, la normas técnicas y especificaciones actuales, y la importancia que tiene la producción de un impreso de calidad, además de la elaboración de una propuesta para la implementación y aplicación de un sistema de calidad basado en la filosofía Six Sigma en las empresas del sector. La impo...

mKikGR, a monomeric photoswitchable fluorescent protein.

Directory of Open Access Journals (Sweden)

Satoshi Habuchi

Full Text Available The recent demonstration and utilization of fluorescent proteins whose fluorescence can be switched on and off has greatly expanded the toolkit of molecular and cell biology. These photoswitchable proteins have facilitated the characterization of specifically tagged molecular species in the cell and have enabled fluorescence imaging of intracellular structures with a resolution far below the classical diffraction limit of light. Applications are limited, however, by the fast photobleaching, slow photoswitching, and oligomerization typical for photoswitchable proteins currently available. Here, we report the molecular cloning and spectroscopic characterization of mKikGR, a monomeric version of the previously reported KikGR that displays high photostability and switching rates. Furthermore, we present single-molecule imaging experiments that demonstrate that individual mKikGR proteins can be localized with a precision of better than 10 nanometers, suggesting their suitability for super-resolution imaging.

Section 508 Electronic Information Accessibility Requirements for Software Development

Science.gov (United States)

Ellis, Rebecca

2014-01-01

Section 508 Subpart B 1194.21 outlines requirements for operating system and software development in order to create a product that is accessible to users with various disabilities. This portion of Section 508 contains a variety of standards to enable those using assistive technology and with visual, hearing, cognitive and motor difficulties to access all information provided in software. The focus on requirements was limited to the Microsoft Windows® operating system as it is the predominant operating system used at this center. Compliance with this portion of the requirements can be obtained by integrating the requirements into the software development cycle early and by remediating issues in legacy software if possible. There are certain circumstances with software that may arise necessitating an exemption from these requirements, such as design or engineering software using dynamically changing graphics or numbers to convey information. These exceptions can be discussed with the Section 508 Coordinator and another method of accommodation used.

Fifteen-year follow-up of pulmonary function in individuals heterozygous for the cystic fibrosis phenylalanine-508 deletion

DEFF Research Database (Denmark)

Dahl, Morten; Nordestgaard, B G; Lange, P

2001-01-01

In a cross-sectional study, we previously showed that cystic fibrosis phenylalanine-508 deletion (DeltaF508) heterozygosity may be overrepresented among individuals with asthma.......In a cross-sectional study, we previously showed that cystic fibrosis phenylalanine-508 deletion (DeltaF508) heterozygosity may be overrepresented among individuals with asthma....

Viabilidade polínica e quantificação de grãos de pólen em espécies de fisális

Directory of Open Access Journals (Sweden)

Daniel Fernandes da Silva

Full Text Available RESUMO O objetivo do trabalho foi elaborar um meio de cultura para avaliação da viabilidade polínica e determinar o número de grãos de pólen por antera e por flor de espécies de fisális. O trabalho foi desenvolvido de forma sequencial, onde grãos de pólen de Physalis (P. angulata,P. ixocarpa,P. minima,P. peruviana e P. pubescens foram submetidos à germinação em meio de cultura desenvolvido em quatro fases: verificação da concentração de ágar e pH, concentração de sacarose, nitrato de cálcio e ácido bórico. Para a contagem de grãos de pólen, cinco anteras foram coletadas entre cinco espécimes representativos de cada espécie, deixadas em repouso para ocorrência da deiscência e posteriormente adicionado ácido lático, para melhoria da visualização do grão de pólen. Após 48 horas o número de grãos de pólen foi quantificado com auxílio de câmara de Neubauer e o número de grãos de pólen por antera determinado por fórmula pré-estabelecida. Observou-se que todas as espécies possuem comportamento semelhante quanto às suas exigências para germinação do grão de pólen, sendo o pH do meio em torno de 5,4 e a concentração de ágar de 8 g L-1; todas as espécies mostram dependência de cálcio e boro para uma melhor viabilidade polínica, destacando-se P. minima em que a adição de boro não propiciou elevação acentuada na porcentagem de germinação. Quanto ao número de grãos de pólen as espécies podem ser divididas em dois grupos, com P. angulata,P. peruviana e P. pubescens com maior número de grãos de pólen por antera e por flor em relação a P. ixocarpa e P. minima.

Continuous state-space representation of a bucket-type rainfall-runoff model: a case study with the GR4 model using state-space GR4 (version 1.0)

Science.gov (United States)

Santos, Léonard; Thirel, Guillaume; Perrin, Charles

2018-04-01

In many conceptual rainfall-runoff models, the water balance differential equations are not explicitly formulated. These differential equations are solved sequentially by splitting the equations into terms that can be solved analytically with a technique called operator splitting. As a result, only the solutions of the split equations are used to present the different models. This article provides a methodology to make the governing water balance equations of a bucket-type rainfall-runoff model explicit and to solve them continuously. This is done by setting up a comprehensive state-space representation of the model. By representing it in this way, the operator splitting, which makes the structural analysis of the model more complex, could be removed. In this state-space representation, the lag functions (unit hydrographs), which are frequent in rainfall-runoff models and make the resolution of the representation difficult, are first replaced by a so-called Nash cascade and then solved with a robust numerical integration technique. To illustrate this methodology, the GR4J model is taken as an example. The substitution of the unit hydrographs with a Nash cascade, even if it modifies the model behaviour when solved using operator splitting, does not modify it when the state-space representation is solved using an implicit integration technique. Indeed, the flow time series simulated by the new representation of the model are very similar to those simulated by the classic model. The use of a robust numerical technique that approximates a continuous-time model also improves the lag parameter consistency across time steps and provides a more time-consistent model with time-independent parameters.

airGR: an R-package suitable for large sample hydrology presenting a suite of lumped hydrological models

Science.gov (United States)

Thirel, G.; Delaigue, O.; Coron, L.; Perrin, C.; Andreassian, V.

2016-12-01

Lumped hydrological models are useful and convenient tools for research, engineering and educational purposes. They propose catchment-scale representations of the precipitation-discharge relationship. Thanks to their limited data requirements, they can be easily implemented and run. With such models, it is possible to simulate a number of hydrological key processes over the catchment with limited structural and parametric complexity, typically evapotranspiration, runoff, underground losses, etc. The Hydrology Group at Irstea (Antony) has been developing a suite of rainfall-runoff models over the past 30 years with the main objectives of designing models as efficient as possible in terms of streamflow simulation, applicable to a wide range of catchments and having low data requirements. This resulted in a suite of models running at different time steps (from hourly to annual) applicable for various issues including water balance estimation, forecasting, simulation of impacts and scenario testing. Recently, Irstea has developed an easy-to-use R-package (R Core Team, 2015; Coron et al., 2016), called airGR, to make these models widely available. It includes: - the water balance annual GR1A (Mouehli et al., 2006), - the monthly GR2M (Mouehli, 2003) models, - three versions of the daily model, namely GR4J (Perrin et al., 2003), GR5J (Le Moine, 2008) and GR6J (Pushpalatha et al., 2011), - the hourly GR4H model (Mathevet, 2005), - a degree-day snow module CemaNeige (Valéry et al., 2014). The airGR package has been designed to facilitate the use by non-expert users and allow the addition of evaluation criteria, models or calibration algorithm selected by the end-user. Each model core is coded in FORTRAN to ensure low computational time. The other package functions (i.e. mainly the calibration algorithm and the efficiency criteria) are coded in R. The package is already used for educational purposes. It allows for convenient implementation of model inter-comparisons and

Representaciones gráficas. Una estrategia didáctica en el planteamiento y resolución de problemas de probabilidad

OpenAIRE

Herrera, Miguel A.; Texta, Oliver; Villagómez, Juan; Ramírez, Pericles; Herrera, Israel; Rivera, Abraham

2012-01-01

Este artículo es el reporte del taller sobre técnicas y estrategias gráficas para la resolución de problemas de probabilidad, llevado a cabo en el Relme 25 celebrado en la Cd. de Camaguey, Cuba, bajo objetivos didácticos que abordan la enseñanza aprendizaje de la probabilidad en el nivel superior. Para ello se seleccionaron y presentaron para su análisis diversos tipos de problemas con el fin de presentar las técnicas apropiadas para su solución. Se contó con la participación de profesores y ...

LeGESD: Un marco de trabajo para la especificación y validación formal de sistemas concurrentes y distribuidos basado en un lenguaje gráfico con semántica sustentada en el álgebra de procesos

Directory of Open Access Journals (Sweden)

Jorge Cortés Galicia

2012-01-01

Full Text Available La especificación y validación formal de sistemas distribuidos es en general una tarea compleja debido a que requiere conocimientos profundos tanto en el área de teoría de algoritmos, como en el modelado de sistemas concurrentes o distribuidos. En este contexto, presentamos LeGESD, un marco de trabajorientado a facilitar la especificación y validación formal de sistemas concurrentes y distribuidos. LeGESD está integrado por un lenguaje gráfico formal para la especificación y análisis de sistemas distribuidos, en el cual esposible incluir tanto los requerimientos funcionales como de comunicación del sistema que se está especificando. La semántica del lenguaje gráfico propuesto incorpora al álgebra de procesos en su definición. Esta semántica también está descrita en el presente documento y se le ha denominado como Análisis y Diseño de Sistemas Distribuidos (ADSD. ADSD es una especificación algebraica con semántica operacional definida para LeGESD, la cual presenta relaciones gráfico-algebraicas de equivalencia que son utilizadas en la especificación formal realizada con LeGESD. Finalmente, en el presente artículo se desarrolla un ejemplo que muestra la utilización y potencialidad tanto del lenguaje como de su semántica asociada

Økologisk frøproduktions rolle i grøntsagsforsyningskæder

DEFF Research Database (Denmark)

Deleuran, Lise Christina; Boelt, Birte

2009-01-01

udsæd. Efterspørgslen var dog ikke helt som forventet. Enten fordi man ikke fik produceret de sorter som grøntsags producenterne ønskede, eller også fordi man fik produceret større mængder af udsæd end der reelt var et marked for. Status er derfor at produktionen af økologisk grønsagsfrø næsten er...

Historia del diseño en El Salvador: El Diseño Gráfico como profesión formal (1978-1988)

OpenAIRE

Colorado Berríos, Jorge Arturo

2014-01-01

El presente artículo trata sobre la historia del diseño gráfico en El Salvador, desde principios del siglo XX hasta 1988, cuando se formaliza como profesión en la Universidad Dr. José Matías Delgado.

25 CFR 20.508 - What must the social services agency do when a child is placed in foster care, residential care...

Science.gov (United States)

2010-04-01

... PROGRAMS Child Assistance Foster Care § 20.508 What must the social services agency do when a child is placed in foster care, residential care or guardianship home? The social services agency must make... placed in foster care, residential care or guardianship home? 20.508 Section 20.508 Indians BUREAU OF...

The coarsening effect of SA508-3 steel used as heavy forgings material

Directory of Open Access Journals (Sweden)

Dingqian Dong

2015-01-01

Full Text Available SA508Gr.3 steel is popularly used to produce core unit of nuclear power reactors due to its outstanding ability of anti-neutron irradiation and good fracture toughness. The forging process takes important role in manufacturing to refine the grain size and improve the material properties. But due to their huge size, heavy forgings cannot be cooled down quickly, and the refined grains usually have long time to grow in high temperature conditions. If the forging process is not adequately scheduled or implemented, very large grains up to millimetres in size may be found in this steel and cannot be eliminated in the subsequent heat treatment. To fix the condition which may causes the coarsening of the steel, hot upsetting experiments in the industrial production environment were performed under different working conditions and the corresponding grain sizes were measured and analysed. The observation showed that the grain will abnormally grow if the deformation is less than a critical value. The strain energy takes a critical role in the grain evolution. If dynamic recrystallization consumes the strain energy as much as possible, the normal grains will be obtained. While if not, the stored strain energy will promote abnormal growth of the grains.

El humor gráfico y la educación de la mirada ambiental / Comics and the education of an environmental gaze

Directory of Open Access Journals (Sweden)

Veronica Carolina Hollman

2012-08-01

Full Text Available La producción y circulación de imágenes ha sido clave en la difusión de las ideas y agendas ambientales. Las imágenes han sido utilizadas como un documento irrefutable de los problemas ambientales y también, como un medio para generar emoción y activar un compromiso en las conductas individuales y colectivas. Las indagaciones que han examinado las representaciones visuales de la naturaleza han privilegiado géneros visuales como la fotografía, el cine y la pintura. En cambio, el humor gráfico - viñetas, comics, historietas- ha sido escasamente analizado. Partimos de la premisa que investigar la relación entre imágenes humorísticas y la cuestión ambiental nos ofrece interesantes elementos para entender el rol que desempeña la cultura visual en la construcción de sentidos y significaciones acerca de la de la naturaleza. Tomamos como corpus de análisis las imágenes humorísticas con contenido ambiental publicadas desde 1996 hasta el año 2010 en una revista de gran circulación en Argentina. Algunos de los interrogantes que articulan esta indagación son los siguientes: ¿Qué temas se introducen desde el humor gráfico como problemas ambientales? ¿Qué relaciones existen entre la agenda ambiental que se configura desde la revista y la que se delinea desde sus secciones de humor? Finalmente nos preguntamos cuáles son las articularidades/potencialidades que este género de imágenes ofrece para pensar la educación ambiental.

Estrategias para inducir la formalidad de la mype de la industria gráfica-offset por medio de gestión competitiva

OpenAIRE

Santander Cjuno, Cintya Kristel

2013-01-01

Esta tesis presenta un Manual orientado a la Micro y Pequeña Empresa (MYPE) de la Industria Gráfica Offset como estrategia ante la informalidad existente de ese sector, utilizando como herramienta competitiva una esquematización de la propuesta de las políticas públicas y Tecnologías de la Información y Comunicación (TIC) que brindan diferentes organismos públicos. La informalidad empresarial ha ido evolucionando con el tiempo, sin que se definan criterios exactos que determinen la formalida...

Mesurar la creativitat en disseny gràfic

OpenAIRE

Ayala Pérez, José

2013-01-01

En aquesta investigació es construeix un marc conceptual, on s'integra la creativitat i el disseny gràfic. S'introdueix el model tridimensional de la creativitat en el disseny gràfic, on la creativitat és disertada en tres dimensions, novetat, comunicació i estètica. Basat en el model tridimensional de la creativitat en Disseny Gràfic, es construeix un instrument per poder mesurar la creativitat d'un disseny gràfic. L'instrument va ser administrat a 115 dissenyadors gràfics del Col · legi de ...

Aproximación a una ontología para lenguajes de modelado gráfico

Directory of Open Access Journals (Sweden)

Marcela Naranjo

2009-05-01

Full Text Available UML, SysML y WebML son lenguajes de modelado gráfico (LMG similares que no se pueden interpretar conjuntamente, pues tienen diferencias en tipos de modelos y diagramas. En la literatura se encuentran técnicas que estudian las características de algunos LMG, pero se aplican sobre lenguajes particulares, sin considerar sus características comunes. En este artículo se propone el diseño e implementación de una ontología que resuma los principales conceptos y relaciones de los LMG, utilizando una metodología creada en la Universidad de Stanford. La ontología desarrollada responde 35 preguntas de competencia, de las cuales algunas se ejemplifican en el artículo./ UML, SysML, and WebML are graphical modeling languages (GML. Despite their similarities, these languages can not be jointly interpreted, since they exhibit different kinds of models and diagrams. Some studies for examining the features of some GML are proposed in the state of the art, but applied to individual languages, avoiding the common features among such languages. In this paper, we propose an ontology design and implementation for summarizing GML concepts and relations. We use a methodology created in the Stanford University. The developed ontology can successfully answer 35 competence questions, some of them exemplified in this paper.

Effect of Cooling Rate on Microstructures and Mechanical Properties in SA508 Gr4N High Strength Low Alloy Steel

Energy Technology Data Exchange (ETDEWEB)

Kim, Minchul; Park, Sanggyu; Choi, Kwonjae; Lee, Bongsang [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2013-05-15

The microstructure of Ni-Cr-Mo low alloy steel is a mixture of tempered martensite and tempered lower bainite and that of Mn-Mo-Ni low alloy steel is predominantly tempered upper bainite. Higher strength and toughness steels are very attractive as an eligible RPV steel, so several researchers have studied to use the Ni-Cr-Mo low alloy steel for the NPP application. Because of the thickness of reactor vessel, there are large differences in austenitizing cooling rates between the surface and the center locations of thickness in RPV. Because the cooling rates after austenitization determine the microstructure, it would affect the mechanical properties in Ni-Cr-Mo low alloy steel, and it may lead to inhomogeneous characteristics when the commercial scale of RPV is fabricated. In order to apply the Ni-Cr-Mo low alloy steel to RPV, it is necessary to evaluate the changes of microstructure and mechanical properties with varying phase fractions in Ni-Cr-Mo low alloy steel. In this study, the effects of martensite and bainite fractions on mechanical properties in Ni-Cr-Mo low alloy steel were examined by controlling the cooling rate after austenitization. First of all, continuous cooling transformation(CCT) diagram was established from the dilatometric analyses. Then, the phase fractions at each cooling rate were quantitatively evaluated. Finally, the mechanical properties were correlated with the phase fraction, especially fraction of martensite in Ni-Cr-Mo low alloy steel.

DeltaF508 heterozygosity in cystic fibrosis and susceptibility to asthma

DEFF Research Database (Denmark)

Dahl, Morten; Tybjaerg-Hansen, A; Lange, P

1998-01-01

Cystic fibrosis is a recessive disorder mainly characterised by lung disease. We tested the hypothesis that individuals heterozygous for the common cystic fibrosis deltaF508 mutation are at risk of obstructive pulmonary disease.......Cystic fibrosis is a recessive disorder mainly characterised by lung disease. We tested the hypothesis that individuals heterozygous for the common cystic fibrosis deltaF508 mutation are at risk of obstructive pulmonary disease....

Gröbner bases statistics and software systems

CERN Document Server

2013-01-01

The idea of the Gröbner basis first appeared in a 1927 paper by F. S. Macaulay, who succeeded in creating a combinatorial characterization of the Hilbert functions of homogeneous ideals of the polynomial ring. Later, the modern definition of the Gröbner basis was independently introduced by Heisuke Hironaka in 1964 and Bruno Buchberger in 1965. However, after the discovery of the notion of the Gröbner basis by Hironaka and Buchberger, it was not actively pursued for 20 years. A breakthrough was made in the mid-1980s by David Bayer and Michael Stillman, who created the Macaulay computer algebra system with the help of the Gröbner basis. Since then, rapid development on the Gröbner basis has been achieved by many researchers, including Bernd Sturmfels. This book serves as a standard bible of the Gröbner basis, for which the harmony of theory, application, and computation are indispensable. It provides all the fundamentals for graduate students to learn the ABC’s of the Gröbner basis, requiring no speci...

Prueba de concepto y ampliación de la librería gráfica de la plataforma Gade4All

OpenAIRE

Guzmán del Río, Borja

2013-01-01

La tendencia de las nuevas tecnologías que se desarrollan actualmente insiste en la automatización de tareas y la orientación del nuevo software al dispositivo móvil. Sin embargo la creación de juegos suele comprender un gran esfuerzo en diseño, animación, creación de la historia, etc., con el correspondiente aumento de presupuesto. Con este objetivo surge Gade4All, una aplicación dedicada a producir juegos para dispositivos móviles de forma masiva, siguiendo la estrategia de obtener benefici...

Systemic administration of thrombin peptide TP508 enhances VEGF-stimulated angiogenesis and attenuates effects of chronic hypoxia

Science.gov (United States)

Olszewska-Pazdrak, Barbara; Carney, Darrell H.

2015-01-01

Revascularization of chronic wounds and ischemic tissue is attenuated by endothelial dysfunction and the inability of angiogenic factors to stimulate angiogenesis. We recently showed that TP508, a nonproteolytic thrombin peptide, increases perfusion and NO-dependent vasodilation in hearts with chronic ischemia and stimulates NO production by endothelial cells. In this study, we investigated systemic in vivo effects of TP508 on VEGF-stimulated angiogenesis in vitro using aortic explants in normoxic and hypoxic conditions. Mice were injected with saline or TP508 and 24h later aortas were removed and cultured to quantify endothelial sprouting. TP508 injection increased endothelial sprouting and potentiated the in vitro response to VEGF. Exposure of control explants to hypoxia inhibited basal and VEGF-stimulated endothelial cell sprouting. This effect of hypoxia was significantly prevented by TP508 injection. Thus, TP508 systemic administration increases responsiveness of aortic endothelial cells to VEGF and diminishes the effect of chronic hypoxia on endothelial cell sprouting. Studies using human endothelial cells in culture suggest that protective effects of TP508 during hypoxia may involve stimulation of endothelial cell NO production. These data suggest potential clinical benefit of using a combination of systemic TP508 and local VEGF as a therapy for revascularization of ischemic tissue. PMID:23594718

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.

Science.gov (United States)

Désiré, J; Mondon, M; Fontelle, N; Nakagawa, S; Hirokami, Y; Adachi, I; Iwaki, R; Fleet, G W J; Alonzi, D S; Twigg, G; Butters, T D; Bertrand, J; Cendret, V; Becq, F; Norez, C; Marrot, J; Kato, A; Blériot, Y

2014-11-28

The glycosidase inhibitory properties of synthetic C-alkyl and N-alkyl six-membered iminosugars have been extensively studied leading to therapeutic candidates. The related seven-membered iminocyclitols have been less examined despite the report of promising structures. Using an in house ring enlargement/C-alkylation as well as cross-metathesis methodologies as the key steps, we have undertaken the synthesis and biological evaluation of a library of fourteen 2C- and eight N-alkyl tetrahydroxylated azepanes starting from an easily available glucopyranose-derived azidolactol. Four, six, nine and twelve carbon atom alkyl chains have been introduced. The study of two distinct D-gluco and L-ido stereochemistries for the tetrol pattern as well as R and S configurations for the C-2 carbon bearing the C-alkyl chain is reported. We observed that C-alkylation of the L-ido tetrahydroxylated azepane converts it from an α-L-fucosidase to a β-glucosidase and β-galactosidase inhibitor while N-alkylation of the D-gluco iminosugar significantly improves its inhibition profile leading to potent β-glucosidase, β-galactosidase, α-L-rhamnosidase and β-glucuronidase inhibitors whatever the stereochemistry of the alkyl chain. Interestingly, the N-alkyl chain length usually parallels the azepane inhibitor potency as exemplified by the identification of a potent glucocerebrosidase inhibitor (Ki 1 μM) bearing a twelve carbon atom chain. Additionally, several C-alkyl azepanes demonstrated promising F508del-CFTR correction unlike the parent tetrahydroxyazepanes. None of the C-alkyl and N-alkyl azepanes did inhibit ER α-glucosidases I or II.

Dokumentaalfilm "Maile Grünbergi värvilised maailmad" = "Maile Grünberg's colourful worlds": a documentary / Karin Paulus, Priit Põldme

Index Scriptorium Estoniae

Paulus, Karin, 1975-

2015-01-01

Sisearhitekt Maile Grünbergist ja 2014. aastal temast valminud dokumentaalfilmist "Maile Grünbergi värvilised maailmad". Režissöör Peeter Brambat, tegevprodutsent Priit Põldme, käsikiri Karin Paulus, Peeter Brambat, Priit Põldme. 2014. aasta Kultuurkapitali Arhitektuuripreemia kandidaat

Aplicación de tecnologías gráficas avanzadas como elemento de apoyo en los procesos de enseñanza-aprendizaje del dibujo, diseño y artes plásticas

OpenAIRE

DE LA TORRE CANTERO, JORGE LUIS

2013-01-01

Los procesos de enseñanza¿aprendizaje del ¿dibujo¿ están muy condicionados por las herramientas gráficas empleadas. En los últimos años, han surgido diversas tecnologías y nuevos contextos educativos (Espacio Europeo de Educación, educación on¿line, ..) que plantean grandes retos en el campo de la enseñanza del ¿dibujo¿. Al mencionar las Tecnologías Gráficas Avanzadas (TGAs) se hace referencia, a aquellas que pueden tener impacto en la enseñanza. En el contexto específ...

Revisión sistemática del efecto de las advertencias gráficas impresas en los paquetes de cigarrillos sobre el comportamiento de los fumadores

Directory of Open Access Journals (Sweden)

Joel Monárrez-Espino

Full Text Available Aplicamos un método estructurado para evaluar si los fumadores activos a los que se les mostraban advertencias gráficas en los paquetes de cigarrillos tenían una probabilidad mayor de abandonar el hábito, reducir el consumo de cigarrillos o intentar dejar de fumar por comparación con fumadores no expuestos. Seleccionamos 21 artículos de entre casi 2500 publicados entre 1993 y 2013, dando prioridad a la cobertura sobre la pertinencia o la calidad porque preveíamos encontrar muy pocos estudios con resultados comportamentales. Observamos una heterogeneidad muy grande entre los estudios, una calidad metodológica deficiente o muy deficiente y resultados por lo general nulos o contradictorios con respecto a cualquier desenlace explorado. Los datos científicos a favor o en contra del uso de las advertencias gráficas son insuficientes, lo cual hace sospechar que cualquier efecto de estas sobre el comportamiento sería moderado. La determinación del efecto individual de las advertencias gráficas sobre el comportamiento requiere de estudios con diseños metodológicos sólidos y períodos de seguimiento más largos.

Corrosion Behavior of SA508 Coupled with and without Magnetite in Chemical Cleaning Environments

International Nuclear Information System (INIS)

Son, Yeong-Ho; Jeon, Soon-Hyeok; Song, Geun Dong; Hur, Do Haeng; Lee, Jong-Hyeon

2017-01-01

To mitigate these problems, chemical cleaning process has been widely used. However, the chemical cleaning solution can affect the corrosion of SG structural materials as well as the magnetite dissolution. During the chemical cleaning process, the galvanic corrosion between SG materials and magnetite is also anticipated because they are in electrical connection. However, the corrosion measurement or monitoring for the materials has been performed without consideration of galvanic effect coupled with magnetite during the chemical cleaning process. In this study, the effect of temperature and EDTA concentration on the corrosion behavior of SA508 tubesheet material with and without magnetite was studied in chemical cleaning solutions. The galvanic corrosion behavior between SA508 and magnetite is predicted by using the mixed potential theory and its effect on the corrosion rate of SA508 is also discussed. By newly designed immersion test, it was confirmed that the extent of galvanic corrosion effect between SA508 and magnetite increased with increasing temperature and EDTA concentration. The galvanic corrosion behavior of SA508 coupled with magnetite in chemical cleaning environments was predicted by the mixed potential theory and verified by ZRA and LP technique. Galvanic coupling increased the corrosion rate of SA508 due to the shift in its potential to the anodic direction. Therefore, the galvanic corrosion effect between SA508 and magnetite should be considered when the corrosion measurement is performed during the chemical cleaning process in steam generators.

Side chain and backbone contributions of Phe508 to CFTR folding

Energy Technology Data Exchange (ETDEWEB)

Thibodeau, Patrick H.; Brautigam, Chad A.; Machius, Mischa; Thomas, Philip J. (U. of Texas-SMED)

2010-12-07

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), an integral membrane protein, cause cystic fibrosis (CF). The most common CF-causing mutant, deletion of Phe508, fails to properly fold. To elucidate the role Phe508 plays in the folding of CFTR, missense mutations at this position were generated. Only one missense mutation had a pronounced effect on the stability and folding of the isolated domain in vitro. In contrast, many substitutions, including those of charged and bulky residues, disrupted folding of full-length CFTR in cells. Structures of two mutant nucleotide-binding domains (NBDs) reveal only local alterations of the surface near position 508. These results suggest that the peptide backbone plays a role in the proper folding of the domain, whereas the side chain plays a role in defining a surface of NBD1 that potentially interacts with other domains during the maturation of intact CFTR.

Estabelecimento de meio de cultura e quantificação da germinação de grãos de pólen de cultivares de marmeleiros

Directory of Open Access Journals (Sweden)

Carolina Ruiz Zambon

2014-06-01

Full Text Available Visando a dar suporte aos trabalhos de melhoramento genético do marmeleiro (Cydoniaoblonga Mill., voltados para a seleção de cultivares altamente produtivas, aptas a serem cultivadas em regiões subtropicais e produtoras de doces de qualidade superior, objetivou-se ajustar o meio de cultura básico para a germinação de grãos de pólen de diferentes cultivares dessa espécie e quantificar o número de estames, número de grãos de pólen por antera e por flor. O pólen utilizado foi da cultivar Portugal, obtido de anteras provenientes de flores em estádio de balão. Em seguida, com auxílio de um pincel, os grãos de pólen foram espalhados sobre a superfície de placas de Petri, contendo 20 mL de meio de cultura, de acordo com os seguintes experimentos: 1 concentrações de ágar (4; 6; 8 e 10 g L-1 e valores de pH (3,5; 4,5; 5,5 e 6,5; 2 concentrações de sacarose (0; 30; 60 e 90 g L-1; 3 concentrações de nitrato de cálcio (0; 200; 400 e 800 mg L-1; 4 concentrações de ácido bórico (0; 400; 800 e 1.200 mg L-1; e 5 tempo de emissão do tubo polínico (0; 1; 2; 3; 4; 5 e 6 horas após a inoculação, os quais foram montados de forma sequencial. Após, avaliou-se a taxa de germinação dos grãos de pólen das 27 cultivares (Alaranjado, Alongado, Apple, BA29, Bereckzy, Champion, Cheldow, Constantinopla, CTS 207, Dangers, De Patras, De Vranja, Dulot, Fuller, Mendoza INTA 37, Kiakami, Lajeado, Meeck Profilic, Meliforme, Pineapple, Portugal, Provence, Radaelli, Rea's Mamouth, Smyrna, Van Deman e Zuquerineta, além do número de estames, número de grãos de pólen por antera e por flor. Realizando-se as leituras da porcentagem de germinação após cinco horas de incubação, conclui-se que o meio de cultura para a germinação de grãos de pólen do marmeleiro deve ser acrescido de 68 g L-1 de sacarose e 366 mg L-1 de ácido bórico, sendo o pH aferido para 5,8 e o meio solidificado com 10 g L-1 de ágar. Foram constatadas diferen

Transformaciones de los procesos imaginativos en la producción gráfica de niños en tratamiento psicopedagógico

OpenAIRE

Wald, Analía Ines; Hamuy, Erica; Guerendian, Natalia; San Sebastián, M. Natalia

2012-01-01

En este artículo se presentarán algunos resultados del proyecto "Procesos imaginativos en los dibujos de niños con problemas de aprendizaje antes y después del tratamiento". (Subsidio IPA 2010-12), enmarcado en el Programa de Investigación de la Cátedra de Psicopedagogía Clínica, Facultad de Psicología, Universidad de Buenos Aires. El objetivo de este estudio es caracterizar las transformaciones en la producción simból ica gráfica en el transcurso del tratamiento y sus vinculaciones con la di...

Current transport in graphene/AlGaN/GaN vertical heterostructures probed at nanoscale.

Science.gov (United States)

Fisichella, Gabriele; Greco, Giuseppe; Roccaforte, Fabrizio; Giannazzo, Filippo

2014-08-07

Vertical heterostructures combining two or more graphene (Gr) layers separated by ultra-thin insulating or semiconductor barriers represent very promising systems for next generation electronics devices, due to the combination of high speed operation with wide-range current modulation by a gate bias. They are based on the specific mechanisms of current transport between two-dimensional-electron-gases (2DEGs) in close proximity. In this context, vertical devices formed by Gr and semiconductor heterostructures hosting an "ordinary" 2DEG can be also very interesting. In this work, we investigated the vertical current transport in Gr/Al(0.25)Ga(0.75)N/GaN heterostructures, where Gr is separated from a high density 2DEG by a ∼ 24 nm thick AlGaN barrier layer. The current transport from Gr to the buried 2DEG was characterized at nanoscale using conductive atomic force microscopy (CAFM) and scanning capacitance microscopy (SCM). From these analyses, performed both on Gr/AlGaN/GaN and on AlGaN/GaN reference samples using AFM tips with different metal coatings, the Gr/AlGaN Schottky barrier height ΦB and its lateral uniformity were evaluated, as well as the variation of the carrier densities of graphene (ngr) and AlGaN/GaN 2DEG (ns) as a function of the applied bias. A low Schottky barrier (∼ 0.40 eV) with excellent spatial uniformity was found at the Gr/AlGaN interface, i.e., lower compared to the measured values for metal/AlGaN contacts, which range from ∼ 0.6 to ∼ 1.1 eV depending on the metal workfunction. The electrical behavior of the Gr/AlGaN contact has been explained by Gr interaction with AlGaN donor-like surface states located in close proximity, which are also responsible of high n-type Gr doping (∼ 1.3 × 10(13) cm(-2)). An effective modulation of ns by the Gr Schottky contact was demonstrated by capacitance analysis under reverse bias. From this basic understanding of transport properties in Gr/AlGaN/GaN heterostructures, novel vertical field effect

Dibujos, imágenes y códigos. Códigos extra-gráficos en el dibujo de arquitectura

OpenAIRE

Allepuz Pedreño, Ángel; Marcos Alba, Carlos Luis; Carrasco Hortal, José

2013-01-01

Esta investigación se desarrolla en el seno de la asignatura de Dibujo 2 del plan de grado en arquitectura de la Universidad de Alicante. El propósito de la misma es abordar cuestiones relativas al discurso pedagógico que se desarrolla en la asignatura y, de forma específica, en la contraposición de los códigos extra-gráficos frente a los códigos gráficos propios del dibujo arquitectónico. Por otro lado, aparece la dialéctica entre dibujos vectoriales y gráficos raster que caracteriza los for...

De la melancolía al horror: una aproximación a la gráfica de Ricardo Warecki

Directory of Open Access Journals (Sweden)

Elisabet Veliscek

2016-01-01

Full Text Available [es] Durante gran parte de su itinerario plástico, el artista rosarino Ricardo Warecki elaboró imágenes gráficas inspiradas en los repertorios iconográficos y en las convenciones estéticas de los movimientos modernos. Las nuevas formas de figuración, el expresionismo y el surrealismo fueron reinterpretados en una clave peculiar a partir de ilustraciones y grabados. En ellos prevalece desde una mirada sobre el sentimiento melancólico hasta paisajes oníricos, donde aparecen el erotismo y la violencia de los márgenes urbanos o la aspereza de la propia naturaleza. Estas imágenes, publicadas en periódicos y revistas culturales de Rosario desde finales de los años treinta hasta los primeros cuarenta, eran acompañadas por relatos literarios con un estilo narrativo cercano a lo fantástico. Si bien dicho vínculo operó como refuerzo de sentidos, Warecki se permitió ciertas licencias que le dejaron explorar significados diversos, excediendo las propias narraciones literarias. En un continuo devenir entre la representación de atmósferas de sosiego y escenarios caóticos, sus ilustraciones exhibieron una mirada cargada de emociones contrapuestas. Una ambigüedad que constituiría un rasgo distintivo tanto de su obra gráfica como de su personalidad. [en] During a large part of their itinerary plastic, the artist of Rosario, Ricardo Warecki, produced graphic images inspired by the iconographic repertoire and the aesthetic forms of the modern movements. The new forms of figuration, expressionism and surrealism were reinterpreted in a peculiar key from illustrations and engravings. Therein prevails since a poetic vision about the melancholic feeling until oneiric landscapes where it appears the eroticism and the violence of the urban margins or the roughness of the nature. These images, published in newspapers and cultural magazines in Rosario from the late thirties until the first forty, were accompanied by stories with a narrative style

17 CFR 249.508 - Form 8-M, consent to service of process by a corporation which is a nonresident broker-dealer.

Science.gov (United States)

2010-04-01

... to service of process by a corporation which is a nonresident broker-dealer. This form shall be filed... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form 8-M, consent to service of process by a corporation which is a nonresident broker-dealer. 249.508 Section 249.508 Commodity...

GRtoGR: a system for mapping GO relations to gene relations.

Science.gov (United States)

Taha, Kamal

2013-12-01

We introduce in this paper a biological search engine called GRtoGR. Given a set of S genes, GRtoGR would determine from GO graph the most significant Lowest Common Ancestor (LCA) of the GO terms annotating the set S. This significant LCA annotates the genes that are the most semantically related to the set S. The framework of GRtoGR refines the concept of LCA by introducing the concepts of Relevant Lowest Common Ancestor (RLCA) and Semantically Relevant Lowest Common Ancestor (SRLCA). A SRLCA is the most significant LCA of the GO terms annotating the set S. We observe that the existence of the GO terms annotating the set S is dependent on the existence of this SRLCA in GO graph. That is, the terms annotating a given set of genes usually have existence dependency relationships with the SRLCA of these terms. We evaluated GRtoGR experimentally and compared it with nine other methods. Results showed marked improvement.

The mechanism of uranium adsorption on Resin 508 and isoelectric point of the resin

International Nuclear Information System (INIS)

Han Qingping; Lu Weichang; Su Huijuan; Hu Jinbo; Zhang Liqin; Chen Banglin

1990-01-01

The adsorption process of uranium by Resin 508 at the solid-liquid interface was investigated and the mechanism of uranium adsorption including adsorption dynamics, adsorption thermodynamics and isoelectric point of resin was studied. The results are as follows: The maximum of uranium adsorption is attained at pH5-7; Uranium adsorption isotherm by Resin 508 in experimental conditions agrees with Langmuir's adsorption isotherm, the maximum of uranium adsorbed (Vm) is 716 mg U/g-dried resin; The adsorption of uranium by Resin 508 is an endothermic reaction and ΔH = 16.87 kJ/mol; The exchange-adsorption rate is mainly controlled by liquid film diffusion; The isoelectric points of Resin 508 before and after uranium adsorption are found to be pH7.5 and pH5.7 respectively. It is a specific adsorption for uranium

Raoul Grünstein : kultuurisponsorlus on turureklaami osa / Imbi Paju

Index Scriptorium Estoniae

Paju, Imbi, 1959-

1998-01-01

Kultuurisponsorlusest Soomes, ettevõtete vähesest huvist kultuuri toetamise vastu varem, suhtumise muutumisest nüüd. Kultuurisponsorluse algataja Soomes - firma Image Match juht, fotokunstnik Raoul Grünstein. Image Matchi klientidest, ettevõtmistest, viimasest projektist - Kiasmale sponsorluse korraldamisest.

GrB TWEAK: A Potential Novel Biologic for NSCLC Therapy

Science.gov (United States)

2017-07-01

granzyme B, lung cancer 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE PERSON USAMRMC a. REPORT...cost extension period we were able to test whether our therapeutic construct GrB-Fc-IT4 could inhibit NSCLC tumor growth in vivo using the NSCLC patient ...derived Fn14-positive cell line M2010-1005. The M2010-1005 line was established from a NSCLC patient with a tumor harboring the EGFRdel747-752

Microstructure and mechanical characteristics of a laser welded joint in SA508 nuclear pressure vessel steel

Energy Technology Data Exchange (ETDEWEB)

Guo, Wei, E-mail: wei.guo-2@manchester.ac.uk [Laser Processing Research Centre, School of Mechanical, Aerospace and Civil Engineering, University of Manchester, Sackville Street, Manchester, M13 9 PL (United Kingdom); Dong, Shiyun [Laser Processing Research Centre, School of Mechanical, Aerospace and Civil Engineering, University of Manchester, Sackville Street, Manchester, M13 9 PL (United Kingdom); Institute of Laser Engineering, Beijing University of Technology, Beijing 100124 (China); Guo, Wei; Francis, John A.; Li, Lin [Laser Processing Research Centre, School of Mechanical, Aerospace and Civil Engineering, University of Manchester, Sackville Street, Manchester, M13 9 PL (United Kingdom)

2015-02-11

SA508 steels are typically used in civil nuclear reactors for critical components such as the reactor pressure vessel. Nuclear components are commonly joined using arc welding processes, but with design lives for prospective new build projects exceeding 60 years, new welding technologies are being sought. In this exploratory study, for the first time, autogenous laser welding was carried out on 6 mm thick SA508 Cl.3 steel sheets using a 16 kW fiber laser system operating at a power of 4 kW. The microstructure and mechanical properties (including microhardness, tensile strength, elongation, and Charpy impact toughness) were characterized and the microstructures were compared with those produced through arc welding. A three-dimensional transient model based on a moving volumetric heat source model was also developed to simulate the laser welding thermal cycles in order to estimate the cooling rates included by the process. Preliminary results suggest that the laser welding process can produce welds that are free of macroscopic defects, while the strength and toughness of the laser welded joint in this study matched the values that were obtained for the parent material in the as-welded condition.

Sandra Szir (coord., Ilustrar e imprimir. Una historia de la cultura gráfica en Buenos Aires, 1830-1930

Directory of Open Access Journals (Sweden)

Antonela Pandolfi

2017-09-01

Full Text Available Reseña bibliográfica del libro de Sandra Szir (coord., Ilustrar e imprimir. Una historia de la cultura gráfica en Buenos Aires, 1830-1930, Buenos Aires, Ampersand, 2016, 298 pp. Ilustrar e imprimir. Una historia de la cultura gráfica en Buenos Aires, 1830-1930 reúne a un grupo de investigadores coordinados por Sandra Szir.  Se toman diferentes objetos de estudio relacionados con el diseño gráfico y se los analizan en función de la disciplina correspondiente pero también relacionados con el contexto histórico en el cual se enmarcan.

GR and ER co-activation alters the expression of differentiation genes and associates with improved ER+ breast cancer outcome

Science.gov (United States)

West, Diana C.; Pan, Deng; Tonsing-Carter, Eva Y.; Hernandez, Kyle M.; Pierce, Charles F.; Styke, Sarah C.; Bowie, Kathleen R.; Garcia, Tzintzuni I.; Kocherginsky, Masha; Conzen, Suzanne D.

2016-01-01

In estrogen receptor (ER)-negative breast cancer (BC), high tumor glucocorticoid receptor (GR) expression has been associated with a relatively poor outcome. In contrast, using a meta-analysis of several genomic datasets, here we find that tumor GR mRNA expression is associated with improved ER+ relapse-free survival (RFS) (independently of progesterone receptor (PR) expression). To understand the mechanism by which GR expression is associated with a better ER+ BC outcome, the global effect of GR-mediated transcriptional activation in ER+ BC cells was studied. Analysis of GR chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) in ER+/GR+ MCF-7 cells revealed that upon co-activation of GR and ER, GR chromatin association became enriched at proximal promoter regions. Furthermore, following ER activation, increased GR chromatin association was observed at ER, FOXO, and AP1 response elements. In addition, ER associated with GR response elements, suggesting that ER and GR interact in a complex. Co-activation of GR and ER resulted in increased expression (relative to ER activation alone) of transcripts that encode proteins promoting cellular differentiation (e.g. KDM4B, VDR) and inhibiting the Wnt-signaling pathway (IGFBP4). Finally, expression of these individual pro-differentiation genes was associated with significantly improved RFS in ER+ BC patients. Together, these data suggest that the co-expression and subsequent activity of tumor cell GR and ER contribute to the less aggressive natural history of early-stage BC by coordinating the altered expression of genes favoring differentiation. Implications The interaction between estrogen and glucocorticoid receptor activity highlights the importance of context-dependent nuclear receptor function in cancer. PMID:27141101

A physically-based constitutive model for SA508-III steel: Modeling and experimental verification

International Nuclear Information System (INIS)

Dong, Dingqian; Chen, Fei; Cui, Zhenshan

2015-01-01

Due to its good toughness and high weldability, SA508-III steel has been widely used in the components manufacturing of reactor pressure vessels (RPV) and steam generators (SG). In this study, the hot deformation behaviors of SA508-III steel are investigated by isothermal hot compression tests with forming temperature of (950–1250)°C and strain rate of (0.001–0.1)s −1 , and the corresponding flow stress curves are obtained. According to the experimental results, quantitative analysis of work hardening and dynamic softening behaviors is presented. The critical stress and critical strain for initiation of dynamic recrystallization are calculated by setting the second derivative of the third order polynomial. Based on the classical stress–dislocation relation and the kinetics of dynamic recrystallization, a two-stage constitutive model is developed to predict the flow stress of SA508-III steel. Comparisons between the predicted and measured flow stress indicate that the established physically-based constitutive model can accurately characterize the hot deformations for the steel. Furthermore, a successful numerical simulation of the industrial upsetting process is carried out by implementing the developed constitutive model into a commercial software, which evidences that the physically-based constitutive model is practical and promising to promote industrial forging process for nuclear components

A physically-based constitutive model for SA508-III steel: Modeling and experimental verification

Energy Technology Data Exchange (ETDEWEB)

Dong, Dingqian [National Die & Mold CAD Engineering Research Center, Shanghai Jiao Tong University, 1954 Huashan Rd., Shanghai 200030 (China); Chen, Fei, E-mail: feechn@gmail.com [National Die & Mold CAD Engineering Research Center, Shanghai Jiao Tong University, 1954 Huashan Rd., Shanghai 200030 (China); Department of Mechanical, Materials and Manufacturing Engineering, University of Nottingham, Nottingham NG7 2RD (United Kingdom); Cui, Zhenshan, E-mail: cuizs@sjtu.edu.cn [National Die & Mold CAD Engineering Research Center, Shanghai Jiao Tong University, 1954 Huashan Rd., Shanghai 200030 (China)

2015-05-14

Due to its good toughness and high weldability, SA508-III steel has been widely used in the components manufacturing of reactor pressure vessels (RPV) and steam generators (SG). In this study, the hot deformation behaviors of SA508-III steel are investigated by isothermal hot compression tests with forming temperature of (950–1250)°C and strain rate of (0.001–0.1)s{sup −1}, and the corresponding flow stress curves are obtained. According to the experimental results, quantitative analysis of work hardening and dynamic softening behaviors is presented. The critical stress and critical strain for initiation of dynamic recrystallization are calculated by setting the second derivative of the third order polynomial. Based on the classical stress–dislocation relation and the kinetics of dynamic recrystallization, a two-stage constitutive model is developed to predict the flow stress of SA508-III steel. Comparisons between the predicted and measured flow stress indicate that the established physically-based constitutive model can accurately characterize the hot deformations for the steel. Furthermore, a successful numerical simulation of the industrial upsetting process is carried out by implementing the developed constitutive model into a commercial software, which evidences that the physically-based constitutive model is practical and promising to promote industrial forging process for nuclear components.

Alterações químicas e nutricionais do grão-de-bico (Cicer arietinum L.) cru irradiado e submetido à cocção

OpenAIRE

Ferreira,Andréa Cristina Penati; Brazaca,Solange Guidolin Canniatti; Arthur,Valter

2006-01-01

O presente trabalho teve por objetivos analisar, em grãos não submetidos à irradiação, a composição centesimal e mineral, para verificar as alterações provocadas pela cocção. Em grãos crus e cozidos, não irradiados (controle) e irradiados (doses de 2, 4, 6, 8 e 10 kGy), foram realizadas também as análises de: disponibilidade de ferro in vitro, digestibilidade da proteína in vitro e perfil de aminoácidos. Os resultados das análises dos minerais demonstraram que ocorreu diminuição significativa...

Introducción a «la otra» novela gráfica para adultos = Introduction to ‘the other’ graphic novel for adults

Directory of Open Access Journals (Sweden)

Antoni Guiral

2015-06-01

Full Text Available Entre finales de los años cincuenta y los setenta del siglo pasado uno de los formatos de edición más habituales en España en la industria de los tebeos fueron las conocidas como novelas gráficas. Cuadernos verticales en formato de bolsillo, con entre 48 y 128 páginas en blanco y negro, llevaron insertos en las portadas el lema «Novelas gráficas para adultos». Herederos, en el tratamiento de los géneros, de la literatura popular y de los cuadernos apaisados de aventuras, estos tebeos generaron miles de páginas realizadas, básicamente, por autores españoles, pero también importadas de países como Francia, Italia o Gran Bretaña. Sustituyeron a los cuadernos apaisados cuando estos empezaron a declinar, ofreciendo un nuevo enfoque en sus argumentos, algo más moderno y vital, y en la estética de sus dibujos. Los editores españoles concibieron estas novelas gráficas para adultos como una forma de evitar la coercitiva legislación que oprimía a los tebeos infantiles y juveniles, pero con la existencia de una censura previa no fueron capaces de dirigirse realmente a un lector adulto. En realidad, se trata de historietas claramente pensadas para un lectorado juvenil.Between the end of the fifties and the seventies of the last century, one of the most common editing formats in Spain in the comics industry were known as graphic novels. Vertical format pocket books with 48 to 128 pages in black and white, they insert in the cover front the theme ‘adult graphic novels’. Heirs, in the treatment of genres, of the popular literature and the horizontal books of adventures, these comics generated thousands of pages created basically by Spanish authors, but also imported from countries like France, Italy or Britain. They replaced the adventures comics in horizontal format when these began to decline, offering a new approach in its arguments, something more modern and vital, and in the aesthetics of his

The Ricor K508 cryocooler operational experience on Mars

Energy Technology Data Exchange (ETDEWEB)

Johnson, Dean L.; Lysek, Mark J.; Morookian, John Michael [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States)

2014-01-29

The Mars Science Laboratory (Curiosity) landed successfully on Mars on August 5, 2012, eight months after launch. The chosen landing site of Gale Crater, located at 4.5 degrees south latitude, 137.4 degrees east longitude, has provided a much more benign environment than was originally planned for during the critical design and integration phases of the MSL Project when all possible landing sites were still being considered. The expected near-surface atmospheric temperatures at the Gale Crater landing site during Curiosity's primary mission (1 Martian year or 687 Earth days) are from −90°C to 0°C. However, enclosed within Curiosity's thermal control fluid loops the Chemistry and Mineralogy (CheMin) instrument is maintained at approximately +20°C. The CheMin instrument uses X-ray diffraction spectroscopy to make precise measurements of mineral constituents of Mars rocks and soil. The instrument incorporated the commercially available Ricor K508 Stirling cycle cryocooler to cool the CCD detector. After several months of brushing itself off, stretching and testing out its subsystems, Curiosity began the exploration of the Mars surface in October 2012. The CheMin instrument on the Mars Science Laboratory (MSL) received its first soil sample from Curiosity on October 24, and successfully analyzed its first soil sample. After a brief review of the rigorous Ricor K508 cooler qualification tests and life tests based on the original MSL environmental requirements this paper presents final pre-launch instrument integration and testing results, and details the operational data of the CheMin cryocooler, providing a snapshot of the resulting CheMin instrument analytical data.

The Ricor K508 cryocooler operational experience on Mars

International Nuclear Information System (INIS)

Johnson, Dean L.; Lysek, Mark J.; Morookian, John Michael

2014-01-01

The Mars Science Laboratory (Curiosity) landed successfully on Mars on August 5, 2012, eight months after launch. The chosen landing site of Gale Crater, located at 4.5 degrees south latitude, 137.4 degrees east longitude, has provided a much more benign environment than was originally planned for during the critical design and integration phases of the MSL Project when all possible landing sites were still being considered. The expected near-surface atmospheric temperatures at the Gale Crater landing site during Curiosity's primary mission (1 Martian year or 687 Earth days) are from −90°C to 0°C. However, enclosed within Curiosity's thermal control fluid loops the Chemistry and Mineralogy (CheMin) instrument is maintained at approximately +20°C. The CheMin instrument uses X-ray diffraction spectroscopy to make precise measurements of mineral constituents of Mars rocks and soil. The instrument incorporated the commercially available Ricor K508 Stirling cycle cryocooler to cool the CCD detector. After several months of brushing itself off, stretching and testing out its subsystems, Curiosity began the exploration of the Mars surface in October 2012. The CheMin instrument on the Mars Science Laboratory (MSL) received its first soil sample from Curiosity on October 24, and successfully analyzed its first soil sample. After a brief review of the rigorous Ricor K508 cooler qualification tests and life tests based on the original MSL environmental requirements this paper presents final pre-launch instrument integration and testing results, and details the operational data of the CheMin cryocooler, providing a snapshot of the resulting CheMin instrument analytical data

El periodismo gráfico durante la dictadura

OpenAIRE

Díaz, César Luis

2017-01-01

Este volumen del Centro de Estudios en Historia/Comunicación/Periodismo/Medios (CEHICOPEME), está dedicado al examen de ocho de los principales medios gráficos argentinos durante la última dictadura cívico-militar. Se trata de una decena de artículos que si bien fueron realizados como obras en sí mismas, no pueden ser aisladas de una forma de concebir la disciplina que las contiene, cuya matriz de producción se gestó en esta Facultad de Periodismo y Comunicación Social (UNLP) hace poco más de...

¿"Libre expresión gráfica" en dictadura? Las Jornadas del Color y de la Forma

Directory of Open Access Journals (Sweden)

Lucía Cañada

2015-03-01

Full Text Available En plena dictadura militar, en Buenos Aires, Mirtha Dermisache y el Taller de Acciones Creativas por ella coordinado organizó una serie de experiencias conocidas como Jornadas del Color y de la Forma. Con un discurso que promovía el desarrollo de la "libre expresión gráfica", los organizadores le proponían a quienes asistían crear libremente. Para ello ponían a su disposición un espacio (que era al mismo tiempo un museo, una variedad de herramientas plásticas y el tiempo que cada uno creía necesario para trabajar. En el presente artículo, nos proponemos reflexionar sobre la existencia de un espacio de este tipo en tiempos de censura y control. Así como también sobre las intenciones de quienes gestaron la idea y la forma en que fue recibida entre los participantes.

Lactobacillus rhamnosus GR-1 in Fermented Rice Pudding Supplemented with Short Chain Inulin, Long Chain Inulin, and Oat as a Novel Functional Food

Directory of Open Access Journals (Sweden)

Maja Williams

2017-10-01

Full Text Available Lactobacillus rhamnosus GR-1 is a probiotic that has been shown to reduce the risk of urogenital problems and urinary tract infections. Rice pudding is a popular gluten-free dairy product, and could be a vehicle to deliver L. rhamnosus GR-1 to a broader population. The purpose of this study was to investigate the growth and viability of L. rhamnosus GR-1 in six fermented rice pudding samples, each one supplemented with one type of prebiotic (short-chain inulin-2% w/w, 4% w/w; long-chain inulin-2% w/w, 4% w/w and oat-0.5% w/w, 1% w/w, along with control, over a 21-day storage period. The objective was to determine if the supplementation would have a positive effect on the microbial viability of L. rhamnosus GR-1, and to evaluate the sensory properties of the samples. All of the samples had viable levels of L. rhamnosus GR-1. Bacterial counts were at least 1 × 108 CFU/mL over the 21-day storage period. The probiotic rice pudding sample supplemented with 4% w/w short-chain inulin had the highest hedonic score for flavour, sweetness, texture, and overall acceptability. This study shows that the addition of short-chain inulin, long-chain inulin, and oat had no adverse supplementation effects on the viability of L. Rhamnosus GR-1. There is the potential for the production of a novel functional food.

Ciudades legibles: los lugares y sus textos. Metodologías de diseño para identificar rasgos gráficos y proyectar sistemas de información visual

OpenAIRE

Wilkomirsky Uribe, Michèle

2016-01-01

Tesis Doctoral leída en la Universidad Rey Juan Carlos de Madrid en 2016. Directora de la Tesis: Isabel del Río de la Hoz Al visitar un lugar por primera vez lo hacemos desde una lejanía intelectual. La gráfica hace que esta lejanía se vuelva proximidad. La comunicación visual es la parte de la disciplina del diseño gráfico que contribuye a legibilizar lo que una ciudad atesora y que no es necesariamente explícita a simple vista. En un lugar ¿ciudad o poblado¿ es casi imposible...

Abanico de Gröbner y politopo de estados de un ideal

OpenAIRE

Rubio de Nicolás, Cristina

2017-01-01

Este trabajo tiene como objetivo hacer un estudio introductorio sobre los ideales iniciales respecto de órdenes monomiales de un ideal I del anillo k[x1;..., xm]. En él se enuncian algunos resultados técnicos sobre bases de Gröbner y geometría poliedral, necesarios para su desarrollo. En el trabajo se comprueba que existe un número finito de tales ideales iniciales, y se define el abanico de Gröbner de I, GF(I). Este abanico es un complejo poliedral de conos en el cual cada cono se correspond...

Influência do etil-trinexapac no acúmulo, na distribuição de nitrogênio (15N e na massa de grãos de arroz de terras altas Influence of ethyl-trinexapac on 15N accumulation and distribution and on highland rice yield

Directory of Open Access Journals (Sweden)

Rita de Cássia Félix Alvarez

2007-12-01

Full Text Available A garantia de alta produtividade de grãos de arroz no sistema de cultivo irrigado por aspersão tem estimulado a utilização de maiores doses de fertilizantes, principalmente os nitrogenados. Contudo, o manejo inadequado da adubação nitrogenada pode resultar em acamamento das plantas. A aplicação de reguladores vegetais pode carrear fotoassimilados para produção de grãos em detrimento do crescimento vegetativo excessivo. Este trabalho teve por objetivos: avaliar a influência do regulador de crescimento etil-trinexapac nas características de crescimento da planta e no acúmulo e distribuição de N (15N nas partes e na planta inteira de arroz; e verificar a contribuição do N absorvido em diferentes estádios de desenvolvimento na formação da panícula, nos componentes do rendimento e na massa de grãos de arroz. O experimento foi realizado em casa de vegetação, sob condições controladas. Os tratamentos foram constituídos de não-aplicação ou aplicação de regulador de crescimento vegetal (0 e 200 g ha-1 i.a. de etil-trinexapac em quatro estádios de desenvolvimento das plantas (1 - início ao final do perfilhamento, 2 - final do perfilhamento à diferenciação do primórdio da panícula, 3 - diferenciação do primórdio da panícula ao florescimento e 4 - florescimento à maturação fisiológica. Foi utilizado o delineamento experimental de blocos ao acaso, dispostos em esquema fatorial 2 x 4, com três repetições. As plantas foram postas em um grupo de 48 vasos. Em um grupo de 24 vasos, com solução nutritiva e NH4SO4 enriquecido (15N, no início de cada estádio preestabelecido de desenvolvimento da planta ao final de cada um deles, as plantas foram coletadas e separadas em suas partes constituintes. Em outro grupo de vasos (24 vasos, no final de cada estádio, em vez de serem coletadas, as plantas voltavam a se desenvolver em solução nutritiva com NH4SO4 natural, para então serem coletadas no final do ciclo. O

Grúas-torre

Directory of Open Access Journals (Sweden)

Chinchilla, M.

1964-09-01

Full Text Available The current large volume of construction, and the new building methods, including large scale préfabrication, have made it necessary to develop adequate machinery to cope with the new requirements. These include the quick distribution of materials and the lifting of large and heavy items. One of these machines which has now attained a widespread use is the tower crane, both of the fixed and moveable type, either on tyres, rails, or of the climbing type. Although these cranes have been known for the last fifty years, their full development only began after the last World War. Their most usual features and varieties make it possible to classify these cranes in a table, which includes most of the models now in standard use.Los nuevos volúmenes de edificación, y los nuevos sistemas, como la prefabricación, han exigido el desarrollo de la maquinaria auxiliar correspondiente, con el fin de poder cubrir las necesidades de alimentación de la obra, reparto de materiales y elevación de cargas y piezas voluminosas. Entre las máquinas auxiliares que h a n obtenido una verdadera mayoría, de edad se encuentran las grúas-torre, fijas, móviles sobre neumáticos o carriles y trepadoras, las cuales, pese a ser conocidas y empleadas desde los años 10, han encontrado su verdadero campo de aplicación después de la segunda guerra mundial. Sus características más comunes respecto a elementos que constituyen la mayor parte de los modelos, permiten agruparlas en una tabla en la que quedan incluidas casi todas las de uso normal.

Stimulation of wild-type, F508del- and G551D-CFTR chloride channels by non toxic modified pyrrolo[2,3-b]pyrazine derivatives

Directory of Open Access Journals (Sweden)

Luc eDannhoffer

2011-08-01

Full Text Available Cystic Fibrosis is a major inherited disorder involving abnormalities of fluid and electrolyte transport in a number of different organs due to abnormal function of Cystic Fibrosis Transmembrane conductance Regulator (CFTR protein. We recently identified a family of CFTR activators, which contains the hit: RP107 [7-n-butyl-6-(4-hydroxyphenyl[5H]-pyrrolo[2,3-b]pyrazine]. Here, we further evaluated the effect of the chemical modifications of the RP107-OH radical on CFTR activation. The replacement of the OH radical by a fluorine atom at position 2 (RP193 or 4 (RP185 significantly decreased the toxicity of the compounds without altering the ability to activate CFTR, especially for RP193. The non-toxic compound RP193 has no effect on cAMP production but stimulates the channel activity of wild-type CFTR in stably transfected CHO cells, in human bronchial epithelial NuLi-1 cells and in primary culture of human bronchial epithelial cells. Whole cell and single patch clamp recordings showed that RP193 induced a linear, time and voltage-independent current, which was fully inhibited by two different and selective CFTR inhibitors (CFTRinh-172 and GPinh-5a. Moreover, RP193 stimulates CFTR in temperature-rescued CuFi-1 (F508del/F508del human bronchial epithelial cells and in CHO cells stably expressing G551D-CFTR. This study shows that it is feasible to reduce cytotoxicity of chemical compounds without affecting their potency to activate CFTR and to rescue the class 2 F508del-CFTR and class 3 G551D-CFTR CF mutant activities.

CXCL17 expression by tumor cells recruits CD11b+Gr1 high F4/80- cells and promotes tumor progression.

Directory of Open Access Journals (Sweden)

Aya Matsui

Full Text Available BACKGROUND: Chemokines are involved in multiple aspects of pathogenesis and cellular trafficking in tumorigenesis. In this study, we report that the latest member of the C-X-C-type chemokines, CXCL17 (DMC/VCC-1, recruits immature myeloid-derived cells and enhances early tumor progression. METHODOLOGY/PRINCIPAL FINDINGS: CXCL17 was preferentially expressed in some aggressive types of gastrointestinal, breast, and lung cancer cells. CXCL17 expression did not impart NIH3T3 cells with oncogenic potential in vitro, but CXCL17-expressing NIH3T3 cells could form vasculature-rich tumors in immunodeficient mice. Our data showed that CXCL17-expressing tumor cells increased immature CD11b(+Gr1(+ myeloid-derived cells at tumor sites in mice and promoted CD31(+ tumor angiogenesis. Extensive chemotactic assays proved that CXCL17-responding cells were CD11b(+Gr1(highF4/80(- cells (≈ 90% with a neutrophil-like morphology in vitro. Although CXCL17 expression could not increase the number of CD11b(+Gr1(+ cells in tumor-burdened SCID mice or promote metastases of low metastatic colon cancer cells, the existence of CXCL17-responding myeloid-derived cells caused a striking enhancement of xenograft tumor formation. CONCLUSIONS/SIGNIFICANCE: These results suggest that aberrant expression of CXCL17 in tumor cells recruits immature myeloid-derived cells and promotes tumor progression through angiogenesis.

Converging shock flows for a Mie-Grüneisen equation of state

Science.gov (United States)

Ramsey, Scott D.; Schmidt, Emma M.; Boyd, Zachary M.; Lilieholm, Jennifer F.; Baty, Roy S.

2018-04-01

Previous work has shown that the one-dimensional (1D) inviscid compressible flow (Euler) equations admit a wide variety of scale-invariant solutions (including the famous Noh, Sedov, and Guderley shock solutions) when the included equation of state (EOS) closure model assumes a certain scale-invariant form. However, this scale-invariant EOS class does not include even simple models used for shock compression of crystalline solids, including many broadly applicable representations of Mie-Grüneisen EOS. Intuitively, this incompatibility naturally arises from the presence of multiple dimensional scales in the Mie-Grüneisen EOS, which are otherwise absent from scale-invariant models that feature only dimensionless parameters (such as the adiabatic index in the ideal gas EOS). The current work extends previous efforts intended to rectify this inconsistency, by using a scale-invariant EOS model to approximate a Mie-Grüneisen EOS form. To this end, the adiabatic bulk modulus for the Mie-Grüneisen EOS is constructed, and its key features are used to motivate the selection of a scale-invariant approximation form. The remaining surrogate model parameters are selected through enforcement of the Rankine-Hugoniot jump conditions for an infinitely strong shock in a Mie-Grüneisen material. Finally, the approximate EOS is used in conjunction with the 1D inviscid Euler equations to calculate a semi-analytical Guderley-like imploding shock solution in a metal sphere and to determine if and when the solution may be valid for the underlying Mie-Grüneisen EOS.

"a view of life" - 18.-30.9.2007 (Sisimiut Museum, Grønland)

DEFF Research Database (Denmark)

Medonos, Jakub Christensen

2007-01-01

Udstilling af og om unge i Sisimiut, Grønland. I Forbindelse med forskningsprojektet; "Ungdom og urbanitet i Grønland - en undersøgelse af den urbane ungdomskultur i Sisimiut: kompetencer, kreativitet og visioner." Se: www.workshop2007.wordpress.com  ......Udstilling af og om unge i Sisimiut, Grønland. I Forbindelse med forskningsprojektet; "Ungdom og urbanitet i Grønland - en undersøgelse af den urbane ungdomskultur i Sisimiut: kompetencer, kreativitet og visioner." Se: www.workshop2007.wordpress.com  ...

Desarrollo de una interfaz gráfica de usuario en entorno MATLAB para el manejo de software de segmentación de imágenes RMN

OpenAIRE

Cancio del Busto, Javier

2011-01-01

Cancio Del Busto, J. (2010). Desarrollo de una interfaz gráfica de usuario en entorno MATLAB para el manejo de software de segmentación de imágenes RMN. http://hdl.handle.net/10251/10184. Archivo delegado

General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels

OpenAIRE

Marcet, Brice; Becq, Frédéric; Norez, Caroline; Delmas, Patrick; Verrier, Bernard

2004-01-01

Cystic fibrosis transmembrane conductance regulator (CFTR) Cl− channel is defective during cystic fibrosis (CF). Activators of the CFTR Cl− channel may be useful for therapy of CF. Here, we demonstrate that a range of general anesthetics like normal-alkanols (n-alkanols) and related compounds can stimulate the Cl− channel activity of wild-type CFTR and delF508-CFTR mutant.The effects of n-alkanols like octanol on CFTR activity were measured by iodide (125I) efflux and patch-clamp techniques o...

Exigências nutricionais da grápia ao fósforo e enxofre em Argissolo Vermelho distrófico arênico: efeito da adubação no crescimento Nutritional demand of grápia to phophorus and sulfur in paleaudalf soil: fertilization effects on growth

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Evandro Luiz Missio

2004-08-01

Full Text Available A grápia (Apuleia leiocarpa Vog. Macbride é uma espécie de grande interesse madeireiro, encontrando-se, atualmente, bastante dizimada devido à exploração extrativista, sem haver reposição através de reflorestamento. O objetivo deste trabalho foi determinar os níveis ótimos de adubação de fósforo e enxofre no crescimento de plantas jovens de grápia. As plantas foram cultivadas em vasos contendo 3,5kg de solo Argissolo Vermelho distrófico arênico, sob condições de casa de vegetação não climatizada. O delineamento experimental foi o inteiramente casualizado com seis repetições. Foram avaliados 16 tratamentos em esquema bifatorial completo (4x4, representados pela combinação de quatro doses de P (0, 60, 120 e 180mg kg-1 e quatro de enxofre (0, 10, 20 e 30mg kg-1. A análise do crescimento das plantas foi realizada mensalmente através da altura da planta, diâmetro do caule e número de folhas remanescentes. Aos 130 dias após a emergência das plantas, avaliaram-se ainda o número de folhas caídas, matéria seca das folhas, caule, raízes e total da planta e a relação entre a matéria seca das raízes e da parte aérea. A produção de matéria seca total das plantas jovens de grápia respondeu positivamente à adubação conjunta de P e S, com dose de máxima eficiência técnica estimada de, respectivamente, 204 e 16mg kg-1 de solo. A adubação fosfatada na dose igual ou acima de 120mg kg-1 de solo induziu o aparecimento de clorose foliar típica da deficiência de Fe. A alta disponibilidade de P no solo favoreceu o crescimento da parte aérea em detrimento das raízes.Grápia (Apuleia leiocarpa Vog. Macbride is an important native forest species that has been in extinction process. The aim of this study was to determine the optimum levels of phosphorus and sulfur fertilization on the initial growth of grápia. Grápia plants were cultivated in pots containing 3.5kg of a Paleudalf soil, under unclimatized glasshouse

Continuous state-space representation of a bucket-type rainfall-runoff model: a case study with the GR4 model using state-space GR4 (version 1.0

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L. Santos

2018-04-01

Full Text Available In many conceptual rainfall–runoff models, the water balance differential equations are not explicitly formulated. These differential equations are solved sequentially by splitting the equations into terms that can be solved analytically with a technique called operator splitting. As a result, only the solutions of the split equations are used to present the different models. This article provides a methodology to make the governing water balance equations of a bucket-type rainfall–runoff model explicit and to solve them continuously. This is done by setting up a comprehensive state-space representation of the model. By representing it in this way, the operator splitting, which makes the structural analysis of the model more complex, could be removed. In this state-space representation, the lag functions (unit hydrographs, which are frequent in rainfall–runoff models and make the resolution of the representation difficult, are first replaced by a so-called Nash cascade and then solved with a robust numerical integration technique. To illustrate this methodology, the GR4J model is taken as an example. The substitution of the unit hydrographs with a Nash cascade, even if it modifies the model behaviour when solved using operator splitting, does not modify it when the state-space representation is solved using an implicit integration technique. Indeed, the flow time series simulated by the new representation of the model are very similar to those simulated by the classic model. The use of a robust numerical technique that approximates a continuous-time model also improves the lag parameter consistency across time steps and provides a more time-consistent model with time-independent parameters.

Protocolo de Actuación para el Análisis del Patrimonio Documental y Bibliográfico desde el Aula de Restauración de Obra Gráfica de la Facultad de Bellas Artes, Universidad de Sevilla

OpenAIRE

Bueno-Vargas, Javier; Vázquez Jiménez, Elena

2015-01-01

En esta comunicación se expone la metodología de trabajo seguida por el alumnado de la asignatura de Intervención en el Patrimonio Documental y Bibliográfico1,2, adscrita al Grado de Conservación y Restauración de la Universidad de Sevilla, para determinar el diagnóstico del estado de conservación de las obras gráficas intervenidas en el aula.

Presentación gráfica, desplazamiento y aprobación de la naturaleza en las expediciones botánicas del siglo XVIII

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Nieto, Mauricio

1995-12-01

Full Text Available My purpose, on this work, is to illustrate the central role that plays the visual representations on the botanical exploration. I used documents (graphics and written from the school of painting of José Celestino Mutis in Santa Fe de Bogotá, that informs us about artists' training and the process of elaboration of sheets; the same as in the newspapers of Ruiz and Pavón during the publication of the Flora Peruviana. The artist's in the process of classification (construction of new species active function stands out.

En este trabajo me propongo ilustrar el papel central que juegan las representaciones visuales en la exploración botánica. Me baso para ello en documentos (gráficos y escritos tanto de la escuela de pintura de José Celestino Mutis en Santa Fe de Bogotá, los cuales nos informan sobre el entrenamiento de artistas y el proceso de elaboración de láminas, al igual que en los diarios de Ruiz y Pavón durante la publicación de la Flora Peruviana. Se destaca la función activa del artista en el proceso de clasificación (fabricación de nuevas especies.

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation.

Science.gov (United States)

De Stefano, Daniela; Villella, Valeria R; Esposito, Speranza; Tosco, Antonella; Sepe, Angela; De Gregorio, Fabiola; Salvadori, Laura; Grassia, Rosa; Leone, Carlo A; De Rosa, Giuseppe; Maiuri, Maria C; Pettoello-Mantovani, Massimo; Guido, Stefano; Bossi, Anna; Zolin, Anna; Venerando, Andrea; Pinna, Lorenzo A; Mehta, Anil; Bona, Gianni; Kroemer, Guido; Maiuri, Luigi; Raia, Valeria

2014-01-01

Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures rescue the functional expression of the most frequent pathogenic CFTR mutant, F508del, at the respiratory epithelial surface and reduce lung inflammation in Cftr(F508del) homozygous mice. Cysteamine, the reduced form of cystamine, is an FDA-approved drug. Here, we report that oral treatment with cysteamine greatly reduces the mortality rate and improves the phenotype of newborn mice bearing the F508del-CFTR mutation. Cysteamine was also able to increase the plasma membrane expression of the F508del-CFTR protein in nasal epithelial cells from F508del homozygous CF patients, and these effects persisted for 24 h after cysteamine withdrawal. Importantly, this cysteamine effect after washout was further sustained by the sequential administration of epigallocatechin gallate (EGCG), a green tea flavonoid, both in vivo, in mice, and in vitro, in primary epithelial cells from CF patients. In a pilot clinical trial involving 10 F508del-CFTR homozygous CF patients, the combination of cysteamine and EGCG restored BECN1, reduced SQSTM1 levels and improved CFTR function from nasal epithelial cells in vivo, correlating with a decrease of chloride concentrations in sweat, as well as with a reduction of the abundance of TNF/TNF-alpha (tumor necrosis factor) and CXCL8 (chemokine [C-X-C motif] ligand 8) transcripts in nasal brushing and TNF and CXCL8 protein levels in the sputum. Altogether, these results suggest that optimal schedules of cysteamine plus EGCG might be used for the treatment of CF caused by the F508del-CFTR mutation.

Aproximación al tratamiento gráfico y visual de las nuevas tecnologías en los periódicos electrónicos

OpenAIRE

Marcos Recio, Juan Carlos

1997-01-01

Desarrollo del concepto de periodismo digital y origen y evolución de los primeros periódicos electrónicos. El tratamiento gráfico y visual en la prensa digital y ejemplos de su uso en periódicos americanos y europeos, con especial referencia a los españoles. Tendencias futuras: el periódico por y para la red.

Síndrome de dolor miofacial de cabeza y cuello: II parte: caracterización gráfica

Directory of Open Access Journals (Sweden)

José Manuel Díaz Fernández¹

1996-08-01

Full Text Available Se realizó un estudio de complementación de los aspectos clínicos del síndrome de dolor miofacial de la cabeza y el cuello (parte I, cuyo fundamento científico se basa en el diseño gráfico de figuras humanas en su porción craneocervicofacial, donde se esquematizan los puntos de transmisión de dolor "activo" o "latente" en el complejo muscular de ambas regiones, así como las áreas de referencia de dolores primario y secundario de la zona craneal y maxilofacial. Se describe la técnica de palpación apropiada para la identificación de estos puntos.A complementary study of the clinical aspects of head and neck myofacial pain syndrome (Part 1, was carried out; its scientific foundation is based on the graphical design of human figures in their cranio-cervico-facial portion, where the "active" or "latent" pain triggering points in the muscular complex of both regions were taken into schemes, as well as the reference areas of primary and secondary pain of the cranial and maxillofacial zones. The adequate palpation technique for the identification of these points, is described.

Conservação de grãos de pólen de mamoneira a baixas temperaturas

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Cristina Copstein Cuchiara

2012-02-01

Full Text Available A finalidade do armazenamento do grão de pólen é conservar material para futura utilização, proporcionando-lhe condições ótimas, de forma a manter seu poder germinativo, vigor e integridade genética originais. O objetivo deste trabalho foi verificar o poder germinativo dos grãos de pólen de mamoneira (Ricinus communis L., após armazenamento a baixas temperaturas. Para tanto, grãos de pólen dos cultivares IAC 80 e AL Guarany 2002 foram utilizados e armazenados em quatro temperaturas: -196, -72, -18 e 4 ºC, durante um período de oito semanas. A avaliação da viabilidade deste pólen foi realizada semanalmente, até completar cinco semanas, sendo realizada uma última avaliação após a oitava semana de armazenamento, por meio do teste de germinação in vitro. Meio de cultura, contendo 10 gL-1 de ágar, 100 gL-1 de sacarose, 0,004 gL-1 de ácido bórico e pH 6,0, foi preparado e depositado em placas de lâmina escavada, onde o pólen foi distribuído sobre a superfície do meio. As placas foram incubadas a 20 ºC em BOD. O delineamento experimental foi inteiramente casualizado, em arranjo fatorial 2 x 4 (2 cultivares x 4 temperaturas para cada tempo de armazenamento, sendo analisados 100 grãos de pólen por repetição, totalizando seis de cada tratamento. Verificou-se diferença significativa entre os tratamentos para a interação cultivar x temperatura na quinta semana de observação (p < 0,05. Demais interações foram altamente significativas em todas as épocas de observação (p < 0,01. Portanto, a utilização de ultrabaixas temperaturas permite a manutenção da viabilidade de grãos de pólen de mamoneira, até a quinta semana de armazenamento.

Intrathecal dihydroergotamine inhibits capsaicin-induced vasodilatation in the canine external carotid circulation via GR127935- and rauwolscine-sensitive receptors.

Science.gov (United States)

Marichal-Cancino, Bruno A; González-Hernández, Abimael; Manrique-Maldonado, Guadalupe; Ruiz-Salinas, Inna I; Altamirano-Espinoza, Alain H; MaassenVanDenBrink, Antoinette; Villalón, Carlos M

2012-10-05

It has been suggested that during a migraine attack trigeminal nerves release calcitonin gene-related peptide (CGRP), producing central nociception and vasodilatation of cranial arteries, including the extracranial branches of the external carotid artery. Since trigeminal inhibition may prevent this vasodilatation, the present study has investigated the effects of intrathecal dihydroergotamine on the external carotid vasodilatation to capsaicin, α-CGRP and acetylcholine. Anaesthetized vagosympathectomized dogs were prepared to measure blood pressure, heart rate and external carotid conductance. A catheter was inserted into the right common carotid artery for the continuous infusion of phenylephrine (to restore the carotid vascular tone), whereas the corresponding thyroid artery was cannulated for one-min intracarotid infusions of capsaicin, α-CGRP and acetylcholine (which dose-dependently increased the external carotid conductance). Another cannula was inserted intrathecally (C(1)-C(3)) for the administration of dihydroergotamine, the α(2)-adrenoceptor antagonist rauwolscine or the serotonin 5-HT(1B/1D) receptor antagonist GR127935 (N-[4-methoxy-3-(4-methyl-1-piperazinyl) phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1-biphenyl]-4-carboxamide hydrochloride monohydrate). Intrathecal dihydroergotamine (10, 31 and 100μg) inhibited the vasodilatation to capsaicin, but not that to α-CGRP or acetylcholine. This inhibition was: (i) unaffected by 10μg GR127935 or 100μg rauwolscine, but abolished by 31μg GR127935 or 310μg rauwolscine at 10μg dihydroergotamine; and (ii) abolished by the combination 10μg GR127935+100μg rauwolscine at 100μg dihydroergotamine. Thus, intrathecal (C(1)-C(3)) dihydroergotamine seems to inhibit the external carotid vasodilatation to capsaicin by spinal activation of serotonin 5-HT(1B/1D) (probably 5-HT(1B)) receptors and α(2) (probably α(2A/2C))-adrenoceptors. Copyright © 2012 Elsevier B.V. All rights reserved.

Structural, Electronic, and Thermodynamic Properties of Tetragonal t-SixGe3−xN4

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Chenxi Han

2018-03-01

Full Text Available The structural, mechanical, anisotropic, electronic, and thermal properties of t-Si3N4, t-Si2GeN4, t-SiGe2N4, and t-Ge3N4 in the tetragonal phase are systematically investigated in the present work. The mechanical stability is proved by the elastic constants of t-Si3N4, t-Si2GeN4, t-SiGe2N4, and t-Ge3N4. Moreover, they all demonstrate brittleness, because B/G < 1.75, and v < 0.26. The elastic anisotropy of t-Si3N4, t-Si2GeN4, t-SiGe2N4, and t-Ge3N4 is characterized by Poisson’s ratio, Young’s modulus, the percentage of elastic anisotropy for bulk modulus AB, the percentage of elastic anisotropy for shear modulus AG, and the universal anisotropic index AU. The electronic structures of t-Si3N4, t-Si2GeN4, t-SiGe2N4, and t-Ge3N4 are all wide band gap semiconductor materials, with band gaps of 4.26 eV, 3.94 eV, 3.83 eV, and 3.25 eV, respectively, when using the Heyd-Scuseria-Ernzerhof (HSE06 hybrid functional. Moreover, t-Ge3N4 is a quasi-direct gap semiconductor material. The thermodynamic properties of t-Si3N4, t-Si2GeN4, t-SiGe2N4, and t-Ge3N4 are investigated utilizing the quasi-harmonic Debye model. The effects of temperature and pressure on the thermal expansion coefficient, heat capacity, Debye temperature, and Grüneisen parameters are discussed in detail.

Economic Analysis of the Greenland Inland Traverse (GrIT)

Science.gov (United States)

2016-06-01

fuel and cargo based on data from the 2012 and 2014 seasons. DISCLAIMER: The contents of this report are not to be used for advertising ...GrIT compared with airlift ....................................................................... 24 13 Fuel consumed by GrIT12 and GrIT14 compared...objective was to identify and quantify, insofar as possible, the component costs of the GrIT and airlift resupply modes. In effect , we sought to link

Rendimento e processo germinativo do grão na espiga de genótipos de trigo

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Felicio João Carlos

2002-01-01

Full Text Available O objetivo deste trabalho foi estudar o processo germinativo dos grãos na espiga, o rendimento de grãos, a adaptabilidade e a estabilidade em genótipos de trigo (Triticum aestivum L. sensíveis às variações ambientais. Os experimentos foram instalados no Núcleo Experimental do Instituto Agronômico, em Campinas, SP, no período de 1996 a 1998. A germinação na espiga foi avaliada pelo método do "Falling Number", que consiste em determinar o nível de atividade da alfa-amilase nos grãos. A segunda e a terceira colheitas foram realizadas ao sete e quatorze dias após a primeira colheita. O atraso da colheita determinou redução no rendimento, notadamente na terceira colheita; os teores de alfa-amilase foram maiores também na terceira colheita, em virtude da degradação dos grãos expostos ao tempo. O genótipo IAC 289 apresentou adaptabilidade a ambientes favoráveis, mas apresentou suscetibilidade à ocorrência de germinação dos grãos na espiga. Os genótipos IAC 24, Mochis, IAC 370 e IAC 351 foram os mais resistentes à germinação dos grãos na espiga, apresentando baixa atividade de alfa-amilase.

Chlorpyrifos promotes colorectal adenocarcinoma H508 cell growth through the activation of EGFR/ERK1/2 signaling pathway but not cholinergic pathway.

Science.gov (United States)

Suriyo, Tawit; Tachachartvanich, Phum; Visitnonthachai, Daranee; Watcharasit, Piyajit; Satayavivad, Jutamaad

2015-12-02

Aside from the effects on neuronal cholinergic system, epidemiological studies suggest an association between chlorpyrifos (CPF) exposure and cancer risk. This in vitro study examined the effects of CPF and its toxic metabolite, chlorpyrifos oxon (CPF-O), on the growth of human colorectal adenocarcinoma H508, colorectal adenocarcinoma HT-29, normal colon epithelial CCD841, liver hepatocellular carcinoma HepG2, and normal liver hepatocyte THLE-3 cells. The results showed that CPF (5-100 μM) concentration-dependently increased viability of H508 and CCD841 cells in serum-free conditions. This increasing trend was not found in HT-29, HepG2 and THLE-3 cells. In contrast, CPF-O (50-100 μM) reduced the viability of all cell lines. Cell cycle analysis showed the induction of cells in the S phase, and EdU incorporation assay revealed the induction of DNA synthesis in CPF-treated H508 cells indicating that CPF promotes cell cycle progression. Despite the observation of acetylcholinesterase activity inhibition and reactive oxygen species (ROS) generation, atropine (a non-selective muscarinic acetylcholine receptor antagonist) and N-acetylcysteine (a potent antioxidant) failed to inhibit the growth-promoting effect of CPF. CPF increased the phosphorylation of epidermal growth factor receptor (EGFR) and its downstream effector, extracellular signal regulated kinase (ERK1/2), in H508 cells. AG-1478 (a specific EGFR tyrosine kinase inhibitor) and U0126 (a specific MEK inhibitor) completely mitigated the growth promoting effect of CPF. Altogether, these results suggest that EGFR/ERK1/2 signaling pathway but not cholinergic pathway involves in CPF-induced colorectal adenocarcinoma H508 cell growth. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

The CFTR-Associated Ligand Arrests the Trafficking of the Mutant ΔF508 CFTR Channel in the ER Contributing to Cystic Fibrosis

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Emily Bergbower

2018-01-01

Full Text Available Background/Aims: The CFTR-Associated Ligand (CAL, a PDZ domain containing protein with two coiled-coil domains, reduces cell surface WT CFTR through degradation in the lysosome by a well-characterized mechanism. However, CAL’s regulatory effect on ΔF508 CFTR has remained almost entirely uninvestigated. Methods: In this study, we describe a previously unknown pathway for CAL by which it regulates the membrane expression of ΔF508 CFTR through arrest of ΔF508 CFTR trafficking in the endoplasmic reticulum (ER using a combination of cell biology, biochemistry and electrophysiology. Results: We demonstrate that CAL is an ER localized protein that binds to ΔF508 CFTR and is degraded in the 26S proteasome. When CAL is inhibited, ΔF508 CFTR retention in the ER decreases and cell surface expression of mature functional ΔF508 CFTR is observed alongside of enhanced expression of plasma membrane scaffolding protein NHERF1. Chaperone proteins regulate this novel process, and ΔF508 CFTR binding to HSP40, HSP90, HSP70, VCP, and Aha1 changes to improve ΔF508 CFTR cell surface trafficking. Conclusion: Our results reveal a pathway in which CAL regulates the cell surface availability and intracellular retention of ΔF508 CFTR.

Grænsestrategier og transnationale relationer

DEFF Research Database (Denmark)

Eilenberg, Michael

2006-01-01

I denne artikel ønsker jeg at undersøge betydningen af transnationale etniske relationer for den indonesiske ibanske befolkning, der er bosat i grænselandet, mellem den malaysiske delstat, Sarawak og den indonesiske provins, Vest Kalimantan. Jeg vil diskutere hvordan transnationale etniske...... disse processer, som de kommer til udtryk i form af bl.a. arbejdsmigration på tværs af den internationale grænse til Sarawak, Malaysia. Udgivelsesdato: Juli...

Implementació d'un Tesselador de DirectX 11 per una targeta gràfica

OpenAIRE

Ramírez Guerrero, Daniel

2012-01-01

El objetivo del proyecto es efectuar un estudio sobre la etapa de teselación de DirectX 11 y ofrecer una implementación de una versión muy básica en el simulador de tarjetas gráficas del proyecto ATTILA.

10 CFR 434.508 - Determination of the design energy consumption and design energy cost.

Science.gov (United States)

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Determination of the design energy consumption and design... Alternative § 434.508 Determination of the design energy consumption and design energy cost. 508.1The Design Energy Consumption shall be calculated by modeling the Proposed Design using the same methods...

General and localized corrosion of carbon and low-alloy steels in oxygenated high-temperature water. Final report

International Nuclear Information System (INIS)

Macdonald, D.D.; Smialowska, S.; Pednekar, S.

1983-02-01

The susceptibilities to stress corrosion cracking (SCC) of two carbon steels, SA106-grB and SA333-gr6, which are used in seamless BWR piping, and a low-alloy pressure vessel steel, A508-C12, were studied in high purity water as a function of oxygen concentration (0.16 to 8 ppM) and temperature (50 to 288 0 C) . The susceptibility to SCC was measured using the slow strain rate technique. The fracture surfaces of the test specimens were also examined using SEM to determine the mode of failure. In water containing 1 and 8 ppM oxygen and at temperatures above 135 0 C, transgranular stress corrosion cracking (TGSCC) was observed to occur in A508-C12, SA333-gr6 and SA106grB steels at very high stresses. The susceptibility to SCC increased with temperature

The last developments of the airGR R-package, an open source software for rainfall-runoff modelling

Science.gov (United States)

Thirel, Guillaume; Delaigue, Olivier; Coron, Laurent; Perrin, Charles; Andréassian, Vazken

2017-04-01

Lumped hydrological models are useful and convenient tools for research, engineering and educational purposes. They propose catchment-scale representations of the precipitation-discharge relationship. Thanks to their limited data requirements, they can be easily implemented and run. With such models, it is possible to simulate a number of hydrological key processes over the catchment with limited structural and parametric complexity, typically evapotranspiration, runoff, underground losses, etc. The Hydrology Group at Irstea (Antony) has been developing a suite of rainfall-runoff models over the past 30 years with the main objectives of designing models as efficient as possible in terms of streamflow simulation, applicable to a wide range of catchments and having low data requirements. This resulted in a suite of models running at different time steps (from hourly to annual) applicable for various issues including water balance estimation, forecasting, simulation of impacts and scenario testing. Recently, Irstea has developed an easy-to-use R-package (R Core Team, 2016), called airGR (Coron et al., 2016, 2017), to make these models widely available. It includes: - the water balance annual GR1A model, - the monthly GR2M model, - three versions of the daily model, namely GR4J, GR5J and GR6J, - the hourly GR4H model, - a degree-day snow model CemaNeige. The airGR package has been designed to facilitate the use by non-expert users and allow the addition of evaluation criteria, models or calibration algorithm selected by the end-user. Each model core is coded in FORTRAN to ensure low computational time. The other package functions (i.e. mainly the calibration algorithm and the efficiency criteria) are coded in R. The package is also used for educational purposes. It allows for convenient implementation of model inter-comparisons and large sample hydrology experiments. The airGR package undergoes continuous developments for improving the efficiency, computational time

Grænser, barrierer og broer

DEFF Research Database (Denmark)

Nortvig, Anne Mette; Christiansen, René B.; Karlsen, Asgjerd Vea

2015-01-01

ledelsesmæssige muligheder for, at skoleklasser i grundskolen kan arbejde sammen og lære på tværs af de tre landes grænser. Nogle af de helt overordnede mål for projektet har således været at udvikle grænseoverskridende undervisningsmodeller i Norden, der kunne mindske de mentale og praktiske barrierer for en...

Reactor pressure vessel steels ASTM A533B and A508 Cl.2

International Nuclear Information System (INIS)

Pelli, R.; Kemppainen, M.; Toerroenen, K.

1979-11-01

This report presents the tensile test results of steels ASTM A533B and A508 Cl.2 obtained in connection with a programme initiated to gather and create information needed for the assessment of the structural integrity of the reactor pressure vessels. The tensile properties were studied between -196 and 300 degC varying austenitizing and tempering temperatures and having two different carbon contents for the heats of A533B. (author)

Diseño, cálculo y comprobación de unión soldada en viga de puente grúa de alma doble

OpenAIRE

Fraile Griborio, Francisco J.

2011-01-01

El trabajo se basa en el diseño y la comprobación de las uniones soldadas en una viga con alma doble que servirá como Puente Grúa. Partiendo de un ejemplo particular de una viga con alma doble (definido por la longitud, la carga máxima y las características químicas y mecánicas de las chapas metálicas) se ha realizado el pre‐dimensionado de la estructura utilizando un programa de cálculo (SAP2000). Los resultados se han comprobado mediante un modelo teórico de cálculo para vigas con alma dobl...

Diseñe su interfaz gráfica con Matlab

Directory of Open Access Journals (Sweden)

Miguel Ramón Ortegón Gutiérrez

1998-05-01

Full Text Available Las aplicaciones de carácter científico o tecnológico cuentan, para su desarrollo, con el apoyo de una poderosa herramienta de cálculo numérico, que permite abordar problemas que demanden variada y compleja manipulación matemática de manera eficiente y con ayudas gráficas. Su diseño funcional le permite usar con facilidad toda la gama de comandos en forma interactiva, o en modo programas que han sido implementados como parte del lenguaje, o los nuevos comandos implementados por el usuario. Problemas tradicionales, relativos al manejo de matrices o álgebra lineal, cálculo diferencial e integral, ecuaciones diferenciales, raíces de funciones, solución de sistemas de ecuaciones, etc., hasta algunos más especializados como el procesamiento digital de señales, redes neuronales, filtros, pueden ser tratados con este lenguaje. Con el presente artículo se desea difundir el uso de interfaces gráficas que provee Matlab, para hacer más modernas, presentables y manejables aplicaciones de ingeniería que con otras herramientas podrían resultar mas complicadas y engorrosas.

Malária em grávidas de uma maternidade pública de Rio Branco (Acre, Brasil Malaria in pregnant women of a public maternity of Rio Branco (Acre State, Brazil

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Regina Jarude

2003-04-01

Full Text Available OBJETIVO: descrever a freqüência dos achados clínico-laboratoriais em grávidas portadoras de malária. MÉTODOS: foi realizado estudo descritivo, série de casos, de 445 grávidas da Maternidade e Clínica de Mulheres Bárbara Heliodora (Rio Branco, Acre, do período de janeiro de 1996 a dezembro de 2001, com diagnóstico parasitológico de malária. Foram revistos os prontuários do período e selecionados os casos portadores de malária. RESULTADOS: no total de pacientes (n=33.420 internadas no período, estavam incluídas 445 (1,4% grávidas. Entre essas, a freqüência da infecção por Plasmodium vivax foi de 52,8% (n=235, por P. falciparum, de 43,8% (n=195, e 3,4% (n=15 por ambos os plasmódios. As alterações clínico-laboratoriais mais freqüentes (pPURPOSE: to describe the frequency of clinical and laboratorial findings in pregnant women with malaria. METHODS: a descriptive study was performed including 445 pregnant women with a positive diagnosis of malaria of the Maternity and women's Clinic Bárbara Heliodora (Rio Branco, Acre State, from January 1996 to December 2001. These cases were reviewed and the pregant women with malaria were selected. RESULTS: a total of 33,420 patients were hospitalized in that period. Of these, 445 pregnant women (1.4% were included. Among these, the frequency of the infection with Plasmodium vivax was 52.8% (n=235, with P. falciparum, 43.8% (n=195, and 3.4% (n=15 with both plasmodia. The most frequent clinical and laboratorial alterations (p<0.05 were observed in the patients with P. falciparum: pale mucosa, jaundice hemoglobin and hematocrit decrease, hypoglycemia and increase in serum aminotransferase, urea, creatinine and in bilirubin levels. Only one patient (1/445, a pregnant woman infected with P. falciparum died. Abortions, premature birth and low birth weight were detected in 1.3, 1.1 and 1.1% of the cases, respectively. CONCLUSIONS: these findings reflect the repercussion of malaria during

Características de carcaça de cordeiros alimentados com grãos e subprodutos da canola = Carcass characteristics in lambs fed with grains and by-products of canola

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José Carlos Barbosa

2009-10-01

Full Text Available O objetivo foi estudar a introdução de 8% de grãos e subprodutos (farelo ou torta da canola em dietas para cordeiros. Para a avaliação das características quantitativas da carcaça, foram utilizadas 24 carcaças de cordeiros, utilizando delineamento inteiramente casualizado. As dietas com média de 15,4% de PB na MS e 80,2% de NDT foram compostas por 40% de feno de capim-Tifton e 60% de concentrado composto por milho em grão, farelo de soja, canola em grão integral, farelo de canola, torta de canola e mistura mineral. A utilização de grãos e subprodutos da canola na dieta de borregos terminados em confinamento não influenciou (p > 0,05 as características quantitativas da carcaça. Em relação aos rendimentos dos cortes, não houve efeito dos tratamentos para nenhuma das variáveis analisadas. Assim, a introdução de 8% de grãos e subprodutos (farelo ou torta da canola possibilitaram bons resultados podendo ser recomendados nas formulações de dietas para cordeiros.The aim of this work was to evaluate the introduction of 8% grains and by-products (meal or cake of canola in the diets of lambs. To evaluate quantitative carcass characteristics, 24 Santa Ines lambs were used in a completely randomized design. Diets with averages of 15.4% of CP in DM and 80.2% of TDN were composed for 40% Tifton hay and 60% concentrate based on corn grain, soybean meal, whole grain canola, canola meal, canola cake and mineral mixture. The use of whole grains and by-products of canola in the diet of lambs finished in feedlot did not influence (p > 0.05 quantitative carcass characteristics. For cut dressing in relation to the CCW, no effect was observed for the analyzed variables among treatments. It was concluded that the introduction of grains and by-products of canola allow for satisfactory results, and could be recommended in the formulations of lamb diets.

Rebound Attacks on the Reduced Grøstl Hash Function

DEFF Research Database (Denmark)

Mendel, Florian; Rechberger, C.; Schlaffer, Martin

2010-01-01

Grøstl is one of 14 second round candidates of the NIST SHA-3 competition. Cryptanalytic results on the wide-pipe compression function of Grøstl-256 have already been published. However, little is known about the hash function, arguably a much more interesting cryptanalytic setting. Also, Grøstl...

5 CFR 9701.508 - Homeland Security Labor Relations Board.

Science.gov (United States)

2010-01-01

... MANAGEMENT SYSTEM (DEPARTMENT OF HOMELAND SECURITY-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM Labor-Management Relations § 9701.508 Homeland Security Labor... impression or a major policy. (2) In cases where the full HSLRB acts, a vote of the majority of the HSLRB (or...

Transcriptomic analysis of Sporisorium reilianum in response to the strigolactone analogue GR24

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Seyed Kazem SABBAGH

2012-09-01

Full Text Available A suppression subtractive hybridization (SSH approach was used to generate cDNA libraries representing genes differentially expressed in the haploid cells of the maize head smut pathogen Sporisorium reilianum exposed to GR24, a strigolactone analogue. Strigolactones are present in root exudates and have been known to trigger germination of parasitic plant seeds and signal mycorrhizal fungi to connect to root systems forming mutualistic relationships. Cell respiration increased within 1 h after GR24 addition, but decreased after 5 and 8 h. All induced cells were used to construct a cDNA library, which contained 1440 clones. The cDNA ESTs were deposited on macro-array membranes and hybridized with P32 cDNA probes obtained from mRNA isolated from S. reilianum yeast cultures exposed or not to 100 nM GR24 for three time intervals. A total of 678 ESTs were identified as differentially expressed during three time-courses in response to GR24. A set of 36 candidate genes were analyzed by qRT-PCR that presented an induction of the genes at 1 h, confirming the hybridization data. Induced genes mostly affect catalysis functions (45% like cell respiration (27%, and cell signaling (26%. Although the biological significance of this perception remains hypothetical, these results indicate that strigolactones could have a wider biological influence in the rhizosphere than previously recognized.

Gr-GDHP: A New Architecture for Globalized Dual Heuristic Dynamic Programming.

Science.gov (United States)

Zhong, Xiangnan; Ni, Zhen; He, Haibo

2017-10-01

Goal representation globalized dual heuristic dynamic programming (Gr-GDHP) method is proposed in this paper. A goal neural network is integrated into the traditional GDHP method providing an internal reinforcement signal and its derivatives to help the control and learning process. From the proposed architecture, it is shown that the obtained internal reinforcement signal and its derivatives can be able to adjust themselves online over time rather than a fixed or predefined function in literature. Furthermore, the obtained derivatives can directly contribute to the objective function of the critic network, whose learning process is thus simplified. Numerical simulation studies are applied to show the performance of the proposed Gr-GDHP method and compare the results with other existing adaptive dynamic programming designs. We also investigate this method on a ball-and-beam balancing system. The statistical simulation results are presented for both the Gr-GDHP and the GDHP methods to demonstrate the improved learning and controlling performance.

On the Computation of Comprehensive Boolean Gröbner Bases

Science.gov (United States)

Inoue, Shutaro

We show that a comprehensive Boolean Gröbner basis of an ideal I in a Boolean polynomial ring B (bar A,bar X) with main variables bar X and parameters bar A can be obtained by simply computing a usual Boolean Gröbner basis of I regarding both bar X and bar A as variables with a certain block term order such that bar X ≫ bar A. The result together with a fact that a finite Boolean ring is isomorphic to a direct product of the Galois field mathbb{GF}_2 enables us to compute a comprehensive Boolean Gröbner basis by only computing corresponding Gröbner bases in a polynomial ring over mathbb{GF}_2. Our implementation in a computer algebra system Risa/Asir shows that our method is extremely efficient comparing with existing computation algorithms of comprehensive Boolean Gröbner bases.

Aprendizaje en la plataforma AVA-AD: la experiencia del curso a distancia “El color en el diseño gráfico”

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Alice Cybis Pereira

2004-06-01

Full Text Available En este artículo presentamos el proyecto Ambientes Virtuales de Aprendizaje en Arquitectura y Diseño (AVA AD. Sus presupuestos teóricos están fundamentados en el aprendizaje basado en solución de problemas (ABP, usando las Tecnologías de la Información y las Comunicaciones (TIC. En el artículo resaltamos las bases conceptuales y técnicas que sustentan las actividades de enseñanza y aprendizaje en el ambiente AVA AD. Examinamos los siguientes ejes conceptuales: producción, comunicación, información y documentación. Asimismo describimos las herramientas vinculadas a dichos ejes conceptuales. Por último, relatamos la experiencia con el curso en línea “El Color en el Diseño Gráfico” desarrollado como piloto del ambiente virtual. En el curso, un grupo de alumnos de diseño resolvieron los problemas planteados acerca del uso del color en el Diseño Gráfico de manera cooperativa y a distancia.

Branding af grønne byer

DEFF Research Database (Denmark)

Konijnendijk, Cecil Cornelis; Petersen, Karen Sejr

2010-01-01

Det grønne - byens parker og natur - kan være med til at skabe en attraktiv by, som har stærk identitet og brand, både for omverden og byens egne borgere.......Det grønne - byens parker og natur - kan være med til at skabe en attraktiv by, som har stærk identitet og brand, både for omverden og byens egne borgere....

Crystal structures of Er4Ni13C4 and UW4C4

International Nuclear Information System (INIS)

Khalili, M.M.; Bodak, O.I.; Marusin, E.P.; Pecharskaya, A.O.

1990-01-01

Crystal structures of Er 4 Ni 13 C 4 (1) (sp.gr. Cmmm, a=1.1975(4), b=1.1694(3), c=0.3856(1) nm, Z=2) and UW 4 C 4 (2) (sp.gr. P4/m, a=0.8328(8), c=0.31345(9) nm, Z=2), relating to new types are determined. Structural type (1) is a derivative of La 2 Ni 5 C 3 structure, structural type (2) is close to UCr 4 C 4 structure

GrOW briefs: From research to policy | IDRC - International ...

International Development Research Centre (IDRC) Digital Library (Canada)

2017-10-17

Oct 17, 2017 ... ​For access to more GrOW findings and literature, visit the GrOW Research Series. Learn more about the GrOW program. What we do · Funding · Resources · About IDRC. Knowledge. Innovation. Solutions. Careers · Contact Us · Site map. Sign up now for IDRC news and views sent directly to your inbox ...

The generic Gröbner walk

DEFF Research Database (Denmark)

Jensen, Anders Nedergaard; Lauritzen, Niels; Fukuda, Komei

2005-01-01

perturbation of this line. This usually involves both time and space demanding arithmetic of integers much larger than the input numbers. In this paper we show how the explicit line may be replaced by a formal line using Robbiano's characterization of group orders on . This gives rise to the generic Gröbner...... walk involving only Gröbner basis conversion over facets and computations with marked polynomials. The infinite precision integer arithmetic is replaced by term order comparisons between (small) integral vectors. This makes it possible to compute with infinitesimal numbers and perturbations...

Feasibility and benefits of group-based exercise in residential aged care adults: a pilot study for the GrACE programme

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Samantha Fien

2016-05-01

Full Text Available The objective of the study was to examine the feasibility and benefits of a group resistance training exercise programme for improving muscle function in institutionalised older adults. A feasibility and acceptability study was designed for a residential aged care (RAC facility, based on the Gold Coast, Australia. Thirty-seven adults, mean age 86.8 ± 6.1 years (30 females living in a RAC facility. Participants were allocated into an exercise (n = 20 or control (n = 17 group. The exercise group, the Group Aged Care Exercise (GrACE programme, performed 12 weeks of twice weekly resistance exercises. Feasibility was measured via recruitment rate, measurement (physiological and surveys completion rate, loss-to-follow-up, exercise session adherence, adverse events, and ratings of burden and acceptability. Muscle function was assessed using gait speed, sit-to-stand and handgrip strength assessments. All intervention participants completed pre- and post-assessments, and the exercise intervention, with 85% (n = 17 of the group attending ≥ 18 of the 24 sessions and 15% (n = 3 attending all sessions. Acceptability was 100% with exercise participants, and staff who had been involved with the programme strongly agreed that the participants “Benefited from the programme.” There were no adverse events reported by any participants during the exercise sessions. When compared to the control group, the exercise group experienced significant improvements in gait speed (F(4.078 = 8.265, p = 0.007, sit to stand performance (F(3.24 = 11.033, p = 0.002 and handgrip strength (F(3.697 = 26.359, p < 0.001. Resistance training via the GrACE programme is feasible, safe and significantly improves gait speed, sit-to-stand performance and handgrip strength in RAC adults.

Characterization of microstructure of A508III/309L/308L weld and oxide films formed in deaerated high-temperature water

Science.gov (United States)

Xiong, Qi; Li, Hongjuan; Lu, Zhanpeng; Chen, Junjie; Xiao, Qian; Ma, Jiarong; Ru, Xiangkun

2018-01-01

The microstructure of A508III/309L/308L weld clad and the properties of the oxide films formed in simulated pressurized water reactor primary water at 290 °C were characterized. The A508III heat-affected zone (HAZ) consisted primarily of a decarburization zone with ferrite near the fusion line and a following pearlite structure with fine grains. A high hardness region in the HAZ could be the result of C-enrichment. M23C6 and M7C3 precipitates were observed in element transition zone. 308L stainless steel (SS) containing ∼ 12% ferrites exhibited both ferritic-austenitic solidification mode (FA mode, δ→γ) and austenitic-ferritic solidification mode (AF mode, γ→δ), whereas 309L SS containing ∼ 9% ferrites exhibited only FA mode. The A508III surface oxide film was mainly Fe3O4 in deaerated high-temperature water. The coarse grain zone covered with few oxide particles was different from other types of film on the other region of HAZ and the bulk zone. More pitting appears on 309L SS after immersion in deaerated high-temperature water due to the dissolution of inclusions. SS surface oxide films consisted primarily of spinels. The oxide film on SS was divided into two layers. Ni was concentrated mainly at the oxide/substrate interface. The oxide film formed on 309L was thicker than that on the 308L. The ferrite in the stainless steel could improve the oxidation resistance.

Crystal structure refinement of α-Si3N4 using synchrotron radiation powder diffraction data: unbiased refinement strategy

International Nuclear Information System (INIS)

Toraya, H.

2000-01-01

The crystal structure of α-silicon nitride (Si 3 N 4 ) was refined by the Rietveld method using synchrotron radiation powder diffraction data (wavelength = 1.2 A) collected at station BL-4B2 in the photon factory. A refinement procedure that adopted a new weight function, w = 1/Y o e (Y o is the observed profile intensity and e ≅ 2), for the least-squares fitting [Toraya (1998). J. Appl. Cryst. 31, 333-343] was studied. The most reasonable structural parameters were obtained with e = 1.7. Crystal data of α-Si 3 N 4 : trigonal, P31c, a = 7.75193 (3), c = 5.61949 (4) A, V = 292.447 (3) A 3 , Z = 4; R p = 5.08, R wp = 6.50, R B = 3.36, R F = 2.26%. The following five factors are considered equally important for deriving accurate structural parameters from powder diffraction data: (i) sufficiently large sin θ/λ range of >0.8 A -1 ; (ii) adequate counting statistics; (iii) correct profile model; (iv) proper weighting on observations to give a uniform distribution of the mean weighted squared residuals; (v) high-angular-resolution powder diffraction data. (orig.)

Characterization of nasal potential difference in cftr knockout and F508del-CFTR mice.

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Emilie Lyne Saussereau

Full Text Available BACKGROUND: Treatments designed to correct cystic fibrosis transmembrane conductance regulator (CFTR defects must first be evaluated in preclinical experiments in the mouse model of cystic fibrosis (CF. Mice nasal mucosa mimics the bioelectric defect seen in humans. The use of nasal potential difference (V(TE to assess ionic transport is a powerful test evaluating the restoration of CFTR function. Nasal V(TE in CF mice must be well characterized for correct interpretation. METHODS: We performed V(TE measurements in large-scale studies of two mouse models of CF--B6;129 cftr knockout and FVB F508del-CFTR--and their respective wild-type (WT littermates. We assessed the repeatability of the test for cftr knockout mice and defined cutoff points distinguishing between WT and F508del-CFTR mice. RESULTS: We determined the typical V(TE values for CF and WT mice and demonstrated the existence of residual CFTR activity in F508del-CFTR mice. We characterized intra-animal variability in B6;129 mice and defined the cutoff points for F508del-CFTR chloride secretion rescue. Hyperpolarization of more than -2.15 mV after perfusion with a low-concentration Cl(- solution was considered to indicate a normal response. CONCLUSIONS: These data will make it possible to interpret changes in nasal V(TE in mouse models of CF, in future preclinical studies.

High pressure behavior of complex phosphate K2Ce[PO4]2: Grüneisen parameter and anharmonicity properties

Science.gov (United States)

Mishra, Karuna Kara; Bevara, Samatha; Ravindran, T. R.; Patwe, S. J.; Gupta, Mayanak K.; Mittal, Ranjan; Krishnan, R. Venkata; Achary, S. N.; Tyagi, A. K.

2018-02-01

Herein we reported structural stability, vibrational and thermal properties of K2Ce[PO4]2, a relatively underexplored complex phosphate of tetravalent Ce4+ from in situ high-pressure Raman spectroscopic investigations up to 28 GPa using a diamond anvil cell. The studies identified the soft phonons that lead to a reversible phase transformation above 8 GPa, and a phase coexistence of ambient (PI) and high pressure (PII) phases in a wider pressure region 6-11 GPa. From a visual representation of the computed eigen vector displacements, the Ag soft mode at 82 cm-1 is assigned as a lattice mode of K+ cation. Pressure-induced positional disorder is apparent from the substantial broadening of internal modes and the disappearance of low frequency lattice and external modes in phase PII above 18 GPa. Isothermal mode Grüneisen parameters γi of the various phonon modes are calculated and compared for several modes. Using these values, thermal properties such as average Grüneisen parameter, and thermal expansion coefficient are estimated as 0.47, and 2.5 × 10-6 K-1, respectively. The specific heat value was estimated from all optical modes obtained from DFT calculations as 314 J-mol-1 K-1. Our earlier reported temperature dependence of phonon frequencies is used to decouple the "true anharmonic" (explicit contribution at constant volume) and "quasi harmonic" (implicit contribution brought out by volume change) contributions from the total anharmonicity. In addition to the 81 cm-1 Ag lattice mode, several other lattice and external modes of PO43- ions are found to be strongly anharmonic.

La música gráfica de León Schidlowsky: Deutschland, ein Wintermárchen (1979 como partitura multimedial The Graphic Music of León Schidlowsky: Deutschland, ein Wintermárchen (1979 as a Multimedia Score

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Daniela Fugellie Videla

2012-12-01

Full Text Available Este estudio aborda la música gráfica de León Schidlowsky (n. 1931, un género que el compositor cultivara mayoritariamente entre los años 1969 y 1984, inmediatamente tras su emigración desde Israel. Su propósito es presentar un panorama general del desarrollo del lenguaje gráfico del compositor y analizar algunos aspectos específicos de su obra Deutschland, ein Wintermárchen (1979, considerada por la autora como un punto culminante de dicho desarrollo. La investigación destaca la concepción multimedial de la obra, derivada de la técnica del collage, la cual logra sintetizar los diversos aspectos musicales, visuales y performativos, para obtener una visualización simultánea de un arte esencialmente temporal. Asimismo, el estudio profundiza en el contenido social y político de la obra. Postula finalmente que esta concepción heterogénea y multifacética es propia de un compositor transcultural, que transita libremente entre culturas y estéticas diversas.This paper deals with the graphic music ofLeón Schidlowsky (b.1931, a genre cultivated by the composermostly from 1969to 1984 afteremigratingfrom Chile to Israel. It presents a generalpanorama ofthe development ofthe graphical language ofthe composer, and analyzes some specific features of his work Deutschland, ein Wintermárchen (1979, considered by the author ofthe article as a culminating point of Schidlowsky's creative development. The research underlines the conception ofthis work as multimedia derived from the collage technique synthesizing the different musical, visual and performative aspects ofthe work into a simultaneous visualization ofwhat amounts to be an essentially temporal art. Besides, the study explores the social and political contents ofthe work, to conclude that this heterogeneous and multifarious conception is a natural feature of a transcultural composer, who moves freely among diverse cultures and aesthetics.

Gründerzeit – Od skandalu do stylu

OpenAIRE

Jacek K. Knothe

2017-01-01

Przyjmuje się, iż architektura ‘okresu założycieli’ – ‘Grűnderzeit’ występowała w Niemczech w latach 1870-1920, to jest dłużej niż do zakończenia I wojny światowej stanowiącej swoistą cezurę XX wieku. Na terenie Polski, w miarę rozprzestrzeniania się przychodzącego z Europy postępu technicznego, styl Grűnderzeit następował pod koniec XIX wieku z niewielkim tylko opóźnieniem w stosunku do Niemiec, a wraz z nim jeszcze 12 stylów okresu historyzmu. Budynki z okresu Grűnderzeit, powszechnie obecn...

Seleção de linhagens de feijoeiro com tipo de grão carioca e com os alelos co-4 e co-5 de resistência à antracnose Selection of common bean strains with carioca grain type, and with the alleles co-4 and co-5 for anthracnose resistance

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Eduardo Henrique Keller Marcondes

2010-08-01

Full Text Available Objetivou-se, neste trabalho, identificar linhagens de feijão que reúnam, além da resistência à antracnose, alta produtividade de grãos do tipo carioca e resistência à mancha angular. Foram utilizadas 194 linhagens F5:6 extraídas de sete famílias segregantes, selecionadas do cruzamento entre os genitores H147 e B1. A linhagem H147 possui grãos tipo carioca, portadora do alelo Co-5, que confere resistência a várias raças de Colletotrichum lindemuthianum. A linhagem B1 também possui grãos tipo carioca e é portadora do alelo Co-4, que confere resistência a outro grupo de raças do mesmo patógeno. As linhagens foram avaliadas na safra das águas 2005/2006, em Lavras, com a cultivar Talismã e H147 como testemunhas, com base na produtividade e tipo de grãos. Foram selecionadas 99 linhagens, as quais foram avaliadas na safra da seca/2006, juntamente com a testemunha Talismã, com base na produtividade, tipo de grão e resistência à mancha angular. Dessas 99 linhagens, foram selecionadas 24, as quais foram avaliadas na safra de inverno/2006 em Lavras e Lambari, com base no tipo de grão e produtividade. Essas 24 linhagens foram inoculadas com a raça 321 de C. lindemuthianum, que quebra a resistência conferida pelo alelo Co-4, mas não o Co-5. Para verificar a presença do alelo Co4 foi utilizado um marcador SCAR que amplifica um fragmento de 950 pb por meio do primer SAS 13. Foi possível identificar 14 linhagens que possuem a pirâmide de alelos Co-4/Co-5 e entre elas, quatro destacaram-se em todos os caracteres avaliados.The objective of the research was to identify bean strains that possess at the same time resistance to anthracnose, high grain yield of Carioca grain type and resistance to angular leaf spot. 194 strains F5:6 were taken from seven segregating families derived from the cross H147 x B1. The H147 line has Carioca grain type and Co-5 resistance allele to several races of C. lindemuthianum. The B1 line also has the

Potencial de rendimento da soja durante a ontogenia em razão da irrigação e arranjo de plantas Potential yield of soybean during the ontogeny according to water availability and plant arrangement

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André Roberto Maehler

2003-02-01

Full Text Available Estimativas do potencial de rendimento (PR da soja podem ser feitas durante a ontogenia pela quantificação das estruturas reprodutivas, de modo a avaliar o efeito de fatores ambientais e práticas de manejo na produção e fixação dessas estruturas. O objetivo deste trabalho foi determinar o efeito da disponibilidade hídrica e arranjo de plantas no PR e seus componentes, durante a ontogenia de duas cultivares de soja. Os tratamentos constituíram-se de dois regimes hídricos (irrigado e não irrigado, duas cultivares (BRS 137 e BRS 138 e três espaçamentos entre linhas (20 cm, 40 cm e 20 e 40 cm em linhas pareadas. O PR médio foi de 15.295 kg ha-1 no estádio de florescimento; 12.325 kg ha-1 na formação de legumes; 5.508 kg ha-1 no início do enchimento de grãos e 4.315 kg ha-1 na maturação. O tratamento irrigado apresentou PR mais elevado em razão da maior produção e fixação de estruturas reprodutivas, mais grãos por legume e grãos mais pesados do que o tratamento não irrigado. Não houve diferença significativa entre espaçamentos. O PR da cultivar BRS 137 é mais elevado do que o da BRS 138, em virtude da menor abscisão de flores, grãos mais pesados e maior número de grãos por legume.The quantification of reproductive structures during the ontogeny allows to estimate soybean yield potential (YP, making possible to quantify the effect of environmental factors and management practices on the production and fixation of these structures. This work aimed to determine the effect of water availability and plant arrangement on the YP and its components, during ontogeny of two soybean cultivars. Treatments were two water availability (irrigated and non irrigated, two cultivars (BRS 137 and BRS 138, and three row spacings (20 cm, 40 cm and 20 and 40 cm in skip row. The average YP obtained was of 15,295 kg ha-1 at blooming; 12,325 kg ha-1 during legume formation; 5,508 kg ha-1 at the beginning of grain filling and 4,315 kg ha-1

Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice.

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Haiya Wu

Full Text Available CFTR (cystic fibrosis transmembrane conductance regulator is expressed by both neutrophils and platelets. Lack of functional CFTR could lead to severe lung infection and inflammation. Here, we found that mutation of CFTR (F508del or inhibition of CFTR in mice led to more severe thrombocytopenia, alveolar neutrocytosis and bacteriosis, and lower lipoxin A4/MIP-2 (macrophage inhibitory protein-2 or lipoxin A4/neutrophil ratios in the BAL (bronchoalveolar lavage during acute E. coli pneumonia. In vitro, inhibition of CFTR promotes MIP-2 production in LPS-stimulated neutrophils; however, lipoxin A4 could dose-dependently suppress this effect. In LPS-induced acute lung inflammation, blockade of PSGL-1 (P-selectin glycoprotein ligand-1 or P-selectin, antagonism of PAF by WEB2086, or correction of mutated CFTR trafficking by KM11060 could significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice. Concurrently, F508del mice had higher plasma platelet activating factor (PAF levels and PAF-AH activity compared to wildtype under LPS challenge. Inhibiting hydrolysis of PAF by a specific PAF-AH (PAF-acetylhydrolase inhibitor, MAFP, could worsen LPS-induced lung inflammation in F508del mice compared to vehicle treated F508del group. Particularly, depletion of platelets in F508del mice could significantly decrease plasma lipoxin A4 and PAF-AH activity and deteriorate LPS-induced lung inflammation compared to control F508del mice. Taken together, lipoxin A4 and PAF are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice, suggesting that lipoxin A4 and PAF might be therapeutic targets for ameliorating CFTR-deficiency deteriorated lung inflammation.

Modos de decir la noticia en la prensa gráfica del norte de Argentina

Directory of Open Access Journals (Sweden)

César Arrueta Parraga

2013-11-01

Full Text Available El objetivo de este trabajo es analizar los modos de decir la noticia de tres diarios del norte de Argentina (Pregón, El Tribuno de Salta y El Liberal, considerando un primer nivel estilístico y un segundo nivel netamente gráfico-espacial. A partir de ello, se propone una reflexión crítica sobre los mecanismos y las modalidades aplicadas sobre la superficie redaccional, identificando necesidades y desafíos pendientes en el contexto de las demandas del mundo digital y la transformación de los hábitos de consumo de medios. Como principales resultados se observa un predominio textual clásico/conservador sobre formas visuales innovadoras; una preponderancia gráfica de la pauta publicitaria y las prioridades editoriales sobre los marcos noticiosos; una disociación estética entre las demandas del público y la propuesta del medio; un complejo y tenso proceso de transición/ negociación entre el formato clásico papel y las propuestas online de cada uno de los pe-riódicos estudiados.

Nutrient consumption pattern of male soccer players in Shiraz/Iran

Directory of Open Access Journals (Sweden)

Saeed Najafpour Bushehry

2003-09-01

Full Text Available Exercise and nutrition have a significant impact on health. To evaluate nutrient consumption pattern of soccer players in city of Shiraz, 323 players were selected by proportional multi-stage cluster random sampling from 11 clubs in Shiraz. Anthropometric indices, socioeconomic status, 24 hours dietary recall and food frequency data were collected. Protein, carbohydrate and fat intake of the players were 73.73 gr (10.8%, 493.3 gr (72.4% and 50.8 gr (16.7%, respectively. Calcium (689.6 mg, phosphorus (734.4 mg, iron (20.3 mg, vitamin B1 (2 mg, vitamin B2 (1.6 mg, vitamin C (107.5 mg and vitamin A (962.4 mcg RE intake were lower than the desirable levels. The mean energy consumption of the players was 2723 Kcal per day. In conclusion, protein and micronutrients intakes are not desirable in Iranian soccer players in Shiraz.

Den grønlandske forbindelse

DEFF Research Database (Denmark)

Jacobsen, Marc

2016-01-01

Danmarks tilstedeværelse i Arktis er helt og aldeles afhængig af, at rigsfællesskabet består. Uden Grønland ville Danmark miste muligheden for at sidde til højbords med USA, Rusland og Canada. En mulighed som, Danmarks størrelse taget i betragtning, er helt unik og af uvurderlig betydning for Dan...... for Danmarks plads i det globale hierarki. Det er derfor alfa og omega, at Danmark fortsat plejer forholdet til Grønland med stor omhu, og at eventuelle uenigheder mellem Nuuk og København bliver taget seriøst og behandlet med stor, gensidig respekt...

Psyken er en grænseflade

DEFF Research Database (Denmark)

Hoffmeyer, Jesper

2011-01-01

En computer er i sig selv blot et stykke mekanik. Det afgørende sker i mødet mellem maskinen, mennesker og fællesskaber: på grænsefladen. Præcis som hos levende væsner......En computer er i sig selv blot et stykke mekanik. Det afgørende sker i mødet mellem maskinen, mennesker og fællesskaber: på grænsefladen. Præcis som hos levende væsner...

31 CFR 535.420 - Transfers of accounts under § 535.508 from demand to interest-bearing status.

Science.gov (United States)

2010-07-01

....508 from demand to interest-bearing status. 535.420 Section 535.420 Money and Finance: Treasury... from demand to interest-bearing status. Section 535.508 authorizes transfer of a blocked demand deposit account to interest-bearing status at the instruction of the Iranian depositor at any time. [44 FR 76784...

Biophysical characterisation of calumenin as a charged F508del-CFTR folding modulator.

Directory of Open Access Journals (Sweden)

Rashmi Tripathi

Full Text Available The cystic fibrosis transmembrane regulator (CFTR is a cyclic-AMP dependent chloride channel expressed at the apical surface of epithelial cells lining various organs such as the respiratory tract. Defective processing and functioning of this protein caused by mutations in the CFTR gene results in loss of ionic balance, defective mucus clearance, increased proliferation of biofilms and inflammation of human airways observed in cystic fibrosis (CF patients. The process by which CFTR folds and matures under the influence of various chaperones in the secretory pathway remains incompletely understood. Recently, calumenin, a secretory protein, belonging to the CREC family of low affinity calcium binding proteins has been identified as a putative CFTR chaperone whose biophysical properties and functions remain uncharacterized. We compared hydropathy, instability, charge, unfoldability, disorder and aggregation propensity of calumenin and other CREC family members with CFTR associated chaperones and calcium binding proteins, wild-type and mutant CFTR proteins and intrinsically disordered proteins (IDPs. We observed that calumenin, along with other CREC proteins, was significantly more charged and less folded compared to CFTR associated chaperones. Moreover like IDPs, calumenin and other CREC proteins were found to be less hydrophobic and aggregation prone. Phylogenetic analysis revealed a close link between calumenin and other CREC proteins indicating how evolution might have shaped their similar biophysical properties. Experimentally, calumenin was observed to significantly reduce F508del-CFTR aggregation in a manner similar to AavLEA1, a well-characterized IDP. Fluorescence microscopy based imaging analysis also revealed altered trafficking of calumenin in bronchial cells expressing F508del-CFTR, indicating its direct role in the pathophysiology of CF. In conclusion, calumenin is characterized as a charged protein exhibiting close similarity with

Oracle JDeveloper 11gR2 Cookbook

CERN Document Server

Haralabidis, Nick

2012-01-01

"Oracle JDeveloper 11gR2 Cookbook" is a practical cookbook which goes beyond the basics with immediately applicable recipes for building ADF applications at an intermediate-to-advanced level. If you are a JavaEE developer who wants to go beyond the basics of building ADF applications with Oracle JDeveloper 11gR2 and get hands on with practical recipes, this book is for you. You should be comfortable with general Java development principles, the JDeveloper IDE, and ADF basics

Análisis, diagnóstico y propuesta de mejora en la gestión de inventarios y de almacenes en una empresa del sector gráfico

OpenAIRE

Vásquez Núñez, Carlos Alberto

2015-01-01

El trabajo que a continuación se presenta ha sido desarrollado en una empresa del sector gráfico ubicada en la ciudad de Lima Metropolitana con presencia comercial en todo el Perú; el objetivo es analizar y diagnosticar la gestión de inventarios y de almacenes para generar una propuesta de mejora que le permita sostener y potenciar sus ventajas competitivas en el ámbito de los operaciones logísticas. La gestión de inventarios vigente no utiliza un método estructurado para el control stocks...

Grüneisen parameter for gases and superfluid helium

International Nuclear Information System (INIS)

De Souza, Mariano; Menegasso, Paulo; Paupitz, Ricardo; Seridonio, Antonio; Lagos, Roberto E

2016-01-01

The Grüneisen ratio (Γ), i.e. the ratio of the thermal expansivity to the specific heat at constant pressure, quantifies the degree of anharmonicity of the potential governing the physical properties of a system. While Γ has been intensively explored in solid state physics, very little is known about its behavior for gases. This is most likely due to the difficulties posed in carrying out both thermal expansion and specific heat measurements in gases with high accuracy as a function of pressure and temperature. Furthermore, to the best of our knowledge a comprehensive discussion about the peculiarities of the Grüneisen ratio is still lacking in the literature. Here we report on a detailed and comprehensive overview of the Grüneisen ratio. Particular emphasis is placed on the analysis of Γ for gases. The main findings of this work are: (i) for the van der Waals gas Γ depends only on the co-volume b due to interaction effects, it is smaller than that for the ideal gas (Γ = 2/3) and diverges upon approaching the critical volume; (ii) for the Bose–Einstein condensation of an ideal boson gas, assuming the transition as first-order, Γ diverges upon approaching a critical volume, similarly to the van der Waals gas; (iii) for 4 He at the superfluid transition Γ shows a singular behavior. Our results reveal that Γ can be used as an appropriate experimental tool to explore pressure-induced critical points. (paper)

Las representaciones gráficas en la enseñanza y en el aprendizaje de la física en la universidad

OpenAIRE

Idoyaga, Ignacio; Lorenzo, Maria Gabriela

2017-01-01

Se presentan la fundamentación y los resultados preliminares del plan de trabajo correspondiente a la tesis “Las representaciones gráficas en la enseñanza y en el aprendizaje de la física en la universidad” en desarrollo en el Centro de Investigación y Apoyo a la Investigación Científica de la Facultad de Farmacia y Bioquímica de la Universidad de Buenos Aires (FFYB-UBA). Este plan propone describir las prácticas áulicas de enseñanza y de aprendizaje de las representaciones gráficas, interpr...

The Intricate Structure of HH 508, the Brightest Microjet in the Orion Nebula

Science.gov (United States)

Wu, Ya-Lin; Close, Laird M.; Kim, Jinyoung Serena; Males, Jared R.; Morzinski, Katie M.

2018-02-01

We present Magellan adaptive optics Hα imaging of HH 508, which has the highest surface brightness among protostellar jets in the Orion Nebula. We find that HH 508 actually has a shorter component to the west, and a longer and knotty component to the east. The east component has a kink at 0.″3 from the jet-driving star θ 1 Ori B2, so it may have been deflected by the wind/radiation from the nearby θ 1 Ori B1B5. The origin of both components is unclear, but if each of them is a separate jet, then θ 1 Ori B2 may be a tight binary. Alternatively, HH 508 may be a slow-moving outflow, and each component represents an illuminated cavity wall. The ionization front surrounding θ 1 Ori B2B3 does not directly face θ 1 Ori B1B5, suggesting that the EUV radiation from θ 1 Ori C plays a dominant role in affecting the morphology of proplyds even in the vicinity of θ 1 Ori B1B5. Finally, we report an Hα blob that might be ejected by the binary proplyd LV 1.

Situação trabalhista da mulher no ciclo grávido-puerperal Situación laboral de la mujer en el ciclo grávido-puerperal Work situation of women in the gravidic-puerperal cycle

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Maria Beatriz de Godoy

2011-03-01

Full Text Available Objetivo. Caracterizar a situação trabalhista de um grupo de mulheres no ciclo grávido-puerperal. Metodologia. Estudo transversal, realizado em 2005 numa Maternidade em Ribeirão Preto - Brasil, que atende exclusivamente pacientes do Sistema Único de Saúde. Participaram 122 puérperas que estiveram no mercado de trabalho no período da gestação. Resultados. Entre as participantes: 52.5% mantinham atividades remuneradas - sendo 45.3% atividade informal-. A gestação foi a razão para a demissão de 79.3% das mulheres. Quando terminem a licença de maternidade as mulheres terão que assumir os labores domésticos e familiares, fora das próprias do trabalho remunerado. Conclusão. A situação trabalhista da população de estudo não sempre é favorável para o exercício dos direitos civis, o que proporciona o desemprego e a deserção trabalhista.Objetivo. Caracterizar la situación laboral de un grupo de mujeres en el ciclo grávido-puerperal. Metodología. Estudio transversal, realizado en 2005 en una Maternidad en Ribeirao Preto - Brazil, que atiende exclusivamente pacientes del Sistema Único de Salud. Participaron 122 puérperas que estuvieron en el mercado de trabajo en el período de la gestación. Resultados. Entre las participantes: 52.5% mantenían actividades remuneradas -siendo 45.3% actividad informal-. La gestación fue la razón para el despido de 79.3% de las mujeres. Cuando terminen la licencia de maternidad las mujeres tendrán que asumir las labores domésticas y familiares, fuera de las propias del trabajo remunerado. Conclusión. La situación laboral de la población de estudio no siempre es favorable para el ejercicio de los derechos civiles, lo que propicia el desempleo y la deserción laboral.Objective. To characterized the work situation of women in the gravid-puerperal cycle. Methodology. Transversal study, performed in 2005 in a maternal unit in Riberirao Preto- Brazil that attends exclusively patients from

Composición Arquitectónica 6. Tema 2: Teorías de intervención en el patrimonio histórico: del monumento arquitectónico al patrimonio urbano - Parte Gráfica 1

OpenAIRE

Martínez-Medina, Andrés

2015-01-01

Parte Gráfica del tema que desarrolla las diferentes actitudes de la arquitectura ante la intervención en el patrimonio, para lo que se sigue el esquema propuesto por Solà-Morales (1982) y se refuerza con el discurso de F. Choay (1992). Se trata de un recorrido cronológico donde se distinguen tres etapas a partir del Renacimiento, con un periodo previo donde no se tenía conciencia de diferenciar en la actuación el tiempo pasado del tiempo presente. Se comienza con un periodo previo de invasió...

Estudo de crianças na reprodução dos componentes gráficos da escrita

Directory of Open Access Journals (Sweden)

Liana Gonçalves Pontes Sodré

Full Text Available Trata-se de um estudo do desenvolvimento motor, no domínio da reprodução dos 16 componentes gráficos responsáveis pela grafia da escrita manuscrita do mundo ocidental. Para tanto, foram observados e registrados os desempenhos de 256 crianças, de ambos os sexos, de dois níveis socioeconômicos (nse, de 3 anos e meio a 7 anos. Elas foram distribuídas em 8 faixas etárias, em intervalos de seis meses, de modo que, em cada faixa etária, ficasse assegurado o mesmo número de meninas e meninos, dos dois nse estudados (médio-alto e baixo. Os resultados indicam que a reprodução da forma dos componentes gráficos é possível desde os 3 anos e meio, porém, a precisão e a firmeza parecem depender de mais exercícios com instrumentos gráficos, como o lápis. Sugestões são feitas para, em estudos posteriores, avaliar melhor a influência da prática no domínio destas habilidades.

30 CFR 285.508 - What rent payments must I pay on ROW grants or RUE grants associated with renewable energy projects?

Science.gov (United States)

2010-07-01

... RUE grants associated with renewable energy projects? 285.508 Section 285.508 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF... § 285.508 What rent payments must I pay on ROW grants or RUE grants associated with renewable energy...

Estrategias semiolingüísticas en el discurso publicitario gráfico del perfume español (años 50-90)

OpenAIRE

Pellicer García, Lidia

2010-01-01

El significado del signo olfativo del perfume español se genera en el discurso publicitario gráfico a través de la función configurante sintácticosemántica que ofrece la narratividad, de la que surgirá la acción y el conflicto de valores, logrando la identidad de marca.

31 CFR 560.508 - Telecommunications and mail transactions authorized.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Telecommunications and mail... REGULATIONS Licenses, Authorizations and Statements of Licensing Policy § 560.508 Telecommunications and mail... telecommunications and mail between the United States and Iran are authorized. For purposes of this section, the term...

Nouvelle manga, mon amour. Reflexiones sobre la narración gráfica de historias cotidianas

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Olalla Hernández Ranz

2010-03-01

Full Text Available Desde sus primeras manifestaciones hace más de un siglo, el cómic se ha ido consolidando como un género popular sobretodo dirigido a un lector juvenil. Su evidente atractivo entre los lectores ha hecho que algunos padres, educadores y profesionales del ámbito de la promoción de la lectura se plantearan el por qué de dicha afición, llegando a conclusiones erróneas como la creencia de que se trata de una lectura menor, dirigida esencialmente a la pura distracción de quien los lee. El manga, en concreto, es el género dentro del cómic que más se consume en occidente. Se ha convertido en un fructífero producto de mercado que deriva en videojuegos, series de televisión, películas de cine… Su gran acogida entre el público infantil y juvenil preocupa a mediadores por la supuesta carga violenta y sexual y la baja calidad literaria de sus obras. El presente propuesta tratará de deshacer algunos tópicos en relación con la concepción errónea la historieta nipona, a partir del estudio de un corpus de obras creadas por autores japoneses y europeos que quieren aportar un cómic de calidad tanto en su forma como en el contenido, abriendo así las puertas a nuevas investigaciones de gran interés. La Novelle manga es un nuevo género dentro del cómic nipón que aúna las estrategias comunicativas más destacables de las novelas gráficas japonesas, el valor estético del cómic francés y la sencillez y el tono de las películas de cine francés dentro de la Nouvelle Vague para crear un cómic que narra historias cotidianas de gran valor literario y estético, muy recomendable para lectores juveniles y adultos.

Diseño de objetos gráficos-interactivos

Directory of Open Access Journals (Sweden)

Eduardo Herrera Fernández

2014-01-01

Full Text Available RESUMEN La mirada, más allá del acto fisiológico de ver, es una construcción compleja. Ante ella, el proceso dialéctico de exploración, control, selección, retorno…, de la interactividad, ofrece una herramienta aparente para consolidar acciones con cualidades cognitivas, productivas y emocionales. Es evidente que reconocemos el término “interactividad” anclado exclusivamente en el dominio de lo digital. El diseño gráfico, por definición, no es interactivo. Sin embargo, las posibilidades que determinan al medio digital, pueden convertirse en recursos adecuados trasladándolos a la materialidad de los objetos impresos, con el objetivo de activar la mirada del usuario. Este potencial estratégico de vitalización comunicativa, y que de alguna manera podría razonarse como “interactivo”, conjunta las operaciones del objeto gráfico y el usuario. Esto permitiría transformar una posible recepción pasiva de este usuario, meramente espectacular, en una función activa. Como planteaba Pierre Lévy, “estamos pasando de la estética del mensaje a la estética de la interactividad”. ABSTRACT Look, beyond the physiological act of seeing, is a complex construction. Considering this, exploration, control, selection, return and others dialectical processes of interactivity, offer an appropiate tool in order to consolidate actions with cognitive, productive and emotional attributes.It is clear that we recognise ‘interactivity’ term as exclusively clung to the digital control. Graphic design us such, is not interactive. Nevertheless, the sort of possibilities that are determining the digital medium, are able to be turned in suitable resources by translating them to the printing objects nature with the aim of stimulate user’s look.This strategic potential of communicational vitalization, which it could be reasoned as ‘interactive’ in some way, combines graphic object operations with the user’s ones. This fact would allow

Neptunyl (NpO₂⁺) interaction with green rust, GR_Na,SO4

DEFF Research Database (Denmark)

Christiansen, Bo C.; Geckeis, Horst; Marquardt, Christian

2011-01-01

Green rust (GR), a member of the Fe(II),Fe(III) layered double hydroxide mineral family, forms in groundwater and during steel corrosion. It has high surface area and is very reactive, especially for redox-sensitive elements such as some actinides. During neutron irradiation of nuclear fuel...... in a reactor, 237Np develops. Although the abundance of Np in spent nuclear fuel is only about 0.05% by mass, it has a very long half life, 2.14 × 106 years, so there is concern about its mobility in the distant future, when radioactive storage sites might be expected to degrade. Under oxidizing conditions...... the final redox speciation of Np, hence its potential mobility, and to characterise changes in the green rust. The GRNa,SO4 sorbed and reduced NpO2+ within minutes. Reduced Np(IV) was primarily found as precipitated nanoparticles at the edges of the GRNa,SO4 crystal platelets. The position of the particles...

41 CFR 302-3.508 - What relocation expenses are not authorized for new appointees or student trainees?

Science.gov (United States)

2010-07-01

... are not authorized for new appointees or student trainees? 302-3.508 Section 302-3.508 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION... relocation expenses are not authorized for new appointees or student trainees? You must not pay any expenses...

Two New Sharp Ostrowski-Grüss Type Inequalities

Directory of Open Access Journals (Sweden)

Zheng Liu

2013-11-01

Full Text Available The purpose of this paper is to use a variant of the Grüss inequality to derive two new sharp Ostrowski-Grüss type inequalities related to a perturbed trapezoidal type rule and a perturbed generalized interior point rule, respectively, which provide improvements of some previous results in the literatures.

Tecnología de gráficos en computadora, enfoques subyacentes a su abordaje en carreras universitarias proyectuales

Directory of Open Access Journals (Sweden)

Balmaceda, María Isabel

2015-12-01

Full Text Available Existen múltiples teorías desde donde se puede entender y definir la tecnología. Cada una de ellas supone diferentes posicionamientos frente a la realidad, condiciona la definición de objetos de estudio y también las metodologías para su abordaje desde la educación. En este trabajo se analizan los posicionamientos que subyacen a tres modalidades diferentes en relación con el abordaje de la “tecnología de gráficos en computadora” (como parte del universo de la tecnología computacional, en carreras universitarias proyectuales. Se plantean las consecuencias de estos enfoques en la formación de los futuros profesionales y se fundamenta por qué se deberían generalizar modalidades que se sustenten en un enfoque crítico frente a la tecnología.

24 CFR 982.508 - Maximum family share at initial occupancy.

Science.gov (United States)

2010-04-01

... URBAN DEVELOPMENT SECTION 8 TENANT BASED ASSISTANCE: HOUSING CHOICE VOUCHER PROGRAM Rent and Housing Assistance Payment § 982.508 Maximum family share at initial occupancy. At the time the PHA approves a... program, and where the gross rent of the unit exceeds the applicable payment standard for the family, the...

Visualidad del producto gráfico

Directory of Open Access Journals (Sweden)

Dr. José Luis Valero Sancho

2002-01-01

Full Text Available Los ojos son una de las vías de entrada de conocimientos más utilizadas por el ser humano, quizá una de las más importantes vías de acceso a la cultura. Pero pueden ser algo más que unos órganos al servicio del hombre, ya que tienen un funcionamiento propio que los hace vulnerables y pueden ser engañados y manipulados desde la apariencia o disposición visual de las cosas. ¿Qué es la visualidad? Según el Diccionario de la Real Academia Española, visual es lo perteneciente a la vista como instrumento o medio para ver y visualidad es el efecto agradable de los objetos vistosos que también pertenece a la vista. Por tanto, no debemos confundir visual con visualidad, pues el primero es el medio y el segundo el efecto que produce la utilización de los ojos y se desarrolla con la experiencia, porque consiste en reconocer y percibir algo que ya ha filtrado el órgano de la vista. ¿Cuándo los productos gráficos tienen visualidad? Cuando una información se explica mejor con estos productos icónicos y tipográficos, percibidos por la vista experta y educada para recibirlos.

Growth and Economic Opportunities for Women (GrOW) Frequently ...

International Development Research Centre (IDRC) Digital Library (Canada)

Alejandra

GrOW will take a broad perspective on the types of questions and evidence on ... question; (2) set the outcome in the broader context of the underlying programme theory, ... Communications from the GrOW team with applicants during the ... There are specific criteria and application processes for this call that should be.

Páginas en emergencia: un itinerario de la novela gráfica en Colombia

Directory of Open Access Journals (Sweden)

Daniel Jiménez Quiroz

2014-12-01

Full Text Available Cómic o historieta son dos términos que usaré de manera indistinta para referirme al mismo objeto artístico: la narrativa gráfica o secuencial. Claramente existen valoraciones culturales distintas en el origen de cada término, pero no pretendo establecer en este artículo un interés de fijación. También puede consultarlo en la versión HTML

GrDHP: a general utility function representation for dual heuristic dynamic programming.

Science.gov (United States)

Ni, Zhen; He, Haibo; Zhao, Dongbin; Xu, Xin; Prokhorov, Danil V

2015-03-01

A general utility function representation is proposed to provide the required derivable and adjustable utility function for the dual heuristic dynamic programming (DHP) design. Goal representation DHP (GrDHP) is presented with a goal network being on top of the traditional DHP design. This goal network provides a general mapping between the system states and the derivatives of the utility function. With this proposed architecture, we can obtain the required derivatives of the utility function directly from the goal network. In addition, instead of a fixed predefined utility function in literature, we conduct an online learning process for the goal network so that the derivatives of the utility function can be adaptively tuned over time. We provide the control performance of both the proposed GrDHP and the traditional DHP approaches under the same environment and parameter settings. The statistical simulation results and the snapshot of the system variables are presented to demonstrate the improved learning and controlling performance. We also apply both approaches to a power system example to further demonstrate the control capabilities of the GrDHP approach.

Módulo de elasticidade de grãos de milho submetidos a impactos mecânicos Modulus of elasticity of shelled corn submitted to mechanical impacts

Directory of Open Access Journals (Sweden)

Solenir Ruffato

2001-04-01

Full Text Available Neste trabalho investigou-se a viabilidade de se obter o módulo de compressão de grãos de milho, utilizando-se dados experimentais de força versus tempo, provenientes de testes de impacto, juntamente com uma análise estrutural elástica do processo. Os módulos de elasticidade foram determinados para grãos, a diferentes teores de umidade, submetidos a impactos de diferentes velocidades, e obtidos por um processo de otimização por meio da técnica de elementos finitos. Dois tipos de módulo foram avaliados: (a um módulo efetivo para todo o grão e (b um módulo para cada uma das três regiões, com diferentes características, segundo as quais o grão foi dividido. O teor de umidade e a velocidade de impacto influenciaram nos valores dos módulos. Módulos para grãos a 13,4% base úmida (b.u. foram maiores do que para aqueles a 20,0% b.u. A análise realizada (elástica mostrou-se ser mais adequada na obtenção de módulos de elasticidade de grãos a 13,4% b.u.; neste teor, os grãos apresentam características elásticas mais pronunciadas que quando a 20,0% b.u. e, nos grãos com altos teores de umidade, as características viscoelásticas tornam-se predominantes.In this study the viability of obtaining the corn compression modulus through an elastic structural analysis was investigated using force versus time data from grain impact tests. The moduli of elasticity of shelled corn at different moisture contents submitted to various impact velocities were determined. The moduli were obtained through an optimization process using the finite element technique. Two kinds of modulus were obtained: (a an effective modulus for the grain and (b a modulus for each one of the three regions, with different characteristics, in which the grain was divided. The moisture content and the impact velocity affected the modulus values. The moduli values for grains at 13.4% wet basis (w.b. were higher than those for grains at 20.0% w.b. The analysis used

Contribuição de caracteres agronômicos para a produtividade de grãos em pinhão-manso

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Paulo Eduardo Teodoro

2016-03-01

Full Text Available RESUMO O conhecimento da associação entre os caracteres que compõem a produtividade é importante para a seleção de plantas superiores, principalmente para garantir que o ganho genético ocorra para os diversos caracteres favoráveis. No pinhão-manso, a produtividade de grãos é o principal alvo do programa de melhoramento, porém existem outros caracteres importantes que impactam na produção. Diante desse contexto, o objetivo deste trabalho foi estimar, por meio de análise de trilha, os efeitos diretos e indiretos de caracteres vegetativos sobre a produtividade de grãos de pinhão-manso. Aos 18 meses após o plantio, foram mensurados os caracteres altura de plantas, diâmetro do caule, número de ramos por planta, projeção da copa na linha, projeção da copa na entrelinha e produtividade de grãos. Foram estimadas as correlações fenotípicas entre os caracteres avaliados, sendo essas correlações desdobradas, por meio da análise de trilha, em efeitos diretos e indiretos, considerando-se o caráter produtividade de grãos como a variável dependente principal. Observou-se que 76% da variação em produtividade foi explicada pelas variáveis explicativas, valor este superior ao observado em outros estudos e adequado para explorar os ganhos com a seleção direta e indireta em pinhão-manso. Os caracteres diâmetro do caule, massa de cem sementes e projeção da copa na entrelinha influenciam diretamente a produtividade de grãos, sendo indicados para seleção direta, assim como para a seleção indireta de progênies superiores de pinhão-manso para produtividade de grãos.

Dendrimer-based selective autophagy-induction rescues ΔF508-CFTR and inhibits Pseudomonas aeruginosa infection in cystic fibrosis.

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Scott Mackenzie Brockman

Full Text Available Cystic Fibrosis (CF is a genetic disorder caused by mutation(s in the CF-transmembrane conductance regulator (Cftr gene. The most common mutation, ΔF508, leads to accumulation of defective-CFTR protein in aggresome-bodies. Additionally, Pseudomonas aeruginosa (Pa, a common CF pathogen, exacerbates obstructive CF lung pathology. In the present study, we aimed to develop and test a novel strategy to improve the bioavailability and potentially achieve targeted drug delivery of cysteamine, a potent autophagy-inducing drug with anti-bacterial properties, by developing a dendrimer (PAMAM-DEN-based cysteamine analogue.We first evaluated the effect of dendrimer-based cysteamine analogue (PAMAM-DENCYS on the intrinsic autophagy response in IB3-1 cells and observed a significant reduction in Ub-RFP and LC3-GFP co-localization (aggresome-bodies by PAMAM-DENCYS treatment as compared to plain dendrimer (PAMAM-DEN control. Next, we observed that PAMAM-DENCYS treatment shows a modest rescue of ΔF508-CFTR as the C-form. Moreover, immunofluorescence microscopy of HEK-293 cells transfected with ΔF508-CFTR-GFP showed that PAMAM-DENCYS is able to rescue the misfolded-ΔF508-CFTR from aggresome-bodies by inducing its trafficking to the plasma membrane. We further verified these results by flow cytometry and observed significant (p<0.05; PAMAM-DEN vs. PAMAM-DENCYS rescue of membrane-ΔF508-CFTR with PAMAM-DENCYS treatment using non-permeabilized IB3-1 cells immunostained for CFTR. Finally, we assessed the autophagy-mediated bacterial clearance potential of PAMAM-DENCYS by treating IB3-1 cells infected with PA01-GFP, and observed a significant (p<0.01; PAMAM-DEN vs. PAMAM-DENCYS decrease in intracellular bacterial counts by immunofluorescence microscopy and flow cytometry. Also, PAMAM-DENCYS treatment significantly inhibits the growth of PA01-GFP bacteria and demonstrates potent mucolytic properties.We demonstrate here the efficacy of dendrimer-based autophagy

Flere grøntsager og fuldkornsprodukter i skolemad

DEFF Research Database (Denmark)

Christensen, Lene Møller; Trolle, Ellen; Lassen, Anne Dahl

2017-01-01

Den mad, danske folkeskoleelever køber gennem deres skolers madordninger, indeholder generelt for lidt fuldkorn og for få grøntsager. DTU Fødevareinstituttet har undersøgt seks skolers indsats med f.eks. at bruge flere grøntsager i varme retter og sandwich og at vælge brød, pasta og ris med...

Gründerzeit – Od skandalu do stylu

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Jacek K. Knothe

2017-12-01

Full Text Available Przyjmuje się, iż architektura ‘okresu założycieli’ – ‘Grűnderzeit’ występowała w Niemczech w latach 1870-1920, to jest dłużej niż do zakończenia I wojny światowej stanowiącej swoistą cezurę XX wieku. Na terenie Polski, w miarę rozprzestrzeniania się przychodzącego z Europy postępu technicznego, styl Grűnderzeit następował pod koniec XIX wieku z niewielkim tylko opóźnieniem w stosunku do Niemiec, a wraz z nim jeszcze 12 stylów okresu historyzmu. Budynki z okresu Grűnderzeit, powszechnie obecne w centrach polskich miast pomimo zniszczeń spowodowanych II wojną, stanowią zwykle obiekty najstarsze i choćby z tego powodu uznawane są za estetyczny kanon historycznej zabudowy mieszkaniowej. Zamiarem autora jest przywrócenie do literatury polskiej terminu Grűnderzeit jako bardziej precyzyjnie określającego styl niż termin ‘historyzm’, używany do opisania praktycznie każdej formy architektonicznej z okresu poprzedzającego modernizm. Autorowi chodzi też o spowodowanie w polskiej literaturze dekonstrukcji terminu ‘historyzm’ i wyodrębnienie z niego terminu Grűnderzeit, ponadto o rozprawienie się z funkcjonującymi na temat stylu Grűnderzeit uprzedzeniami oraz o wykazanie związków i wpływu tego stylu na architekturę tkanki miejskiej większości polskich miast, nie tylko tych położonych na zachód od Wisły. Bezrefleksyjność lub też pogląd, iż architektura z przełomu XIX i XX wieku na terenie Polski nie miała korzeni w XIX wiecznej architekturze Europy, a jeśli nawet miała, to na pewno nie były one niemieckie, w erze globalizmu która właśnie wtedy się rozpoczynała, nie wytrzymuje próby.

Nitrogênio disponível ao milho: crescimento, absorção e rendimento de grãos Nitrogen available to maize: absorption, growth and yield

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Solange França

2011-11-01

Full Text Available Este trabalho visou quantificar o nitrogênio (N disponível ao milho e avaliar seu efeito sobre o índice de área foliar (IAF, a produção de massa seca da parte aérea (MSPA, o N absorvido pela parte aérea e o rendimento de grãos. As avaliações foram realizadas aos 52, 65, 74, 82, 99 e 160 dias após a emergência (DAE em um experimento de manejo de solo conduzido em plantio direto desde 1985, com os sistemas de culturas de aveia/milho (A/M, aveia + ervilhaca/milho + caupi (A+E/M+C e ervilhaca/milho (E/M e duas doses de N (0 N e 180 N - kg ha-1 aplicadas no milho, na forma de uréia. Na safra 2000/01 foram aplicadas doses de 0, 60, 120 e 180 kg ha-1 de N. O N estimado disponível ao milho e calculado a partir da contribuição do solo, plantas de cobertura e do adubo nitrogenado, variou de 27 a 192 kg ha-1, sendo os menores valores associados aos tratamentos apenas com gramíneas (A/M e os maiores aos com N e presença de leguminosas no sistema (E/M e A+E/M+C. Todas as variáveis avaliadas apresentaram alta dependência do N disponível e tiveram seus valores maximizados próximos da maior disponibilidade de N (192 kg ha-1. Com esta disponibilidade foram observados, no estádio de polinização (65 DAE, o maior IAF (4,41 e a mais alta concentração de N na folha índice (2,49%, enquanto o maior acúmulo de N na parte aérea foi constatado no estádio de grão leitoso (74 DAE e o acúmulo de MSPA no estádio de grão dentado (99 DAE. O rendimento máximo de grãos atingido foi de 8.920 kg ha-1, correspondendo a uma exportação de N pelo grão, de 112 kg ha-1.This work aimed to quantify the available nitrogen (N to a maize crop and evaluate its effects on leaf area index (LAI, shoot dry matter (SDM production, N absorption by the above ground biomass, and grain yield. The evaluations were performed in a soil management experiment run since 1985, with three cropping systems (oat - Avena strigosa/maize, oat + vetch - Vicia sativa/maize and

N = 4 super KdV hierarchy in N = 4 and N = 2 superspaces

International Nuclear Information System (INIS)

Delduc, F.

1995-10-01

The results of further analysis of the integrability properties of the N = 4 supersymmetric KdV equation deduced earlier as a Hamiltonian flow on N 4 SU(2) superconformal algebra in the harmonic N = 4 superspace are presented. To make this equation and the relevant Hamiltonian structures more tractable, it is reformulated in the ordinary N = 4 and further in N = 2 superspaces. These results provide a strong evidence that the unique N = 4 SU(2) super KdV hierarchy exists. (author)

Cenários prospectivos da produção e armazenagem de grãos no Brasil

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Gabriel Debarba Baroni

2017-12-01

Full Text Available Com o aumento da população mundial e, consequentemente, da demanda por alimento, o tema produção e armazenamento de grãos se faz relevante, tanto em nível nacional como internacional. Sabe-se que o Brasil é um dos maiores produtores de grãos do mundo, devido, principalmente, a sua grande extensão territorial, clima favorável e utilização de tecnologia para manejo da lavoura. Mas, além de produzir, é de fundamental importância efetuar o armazenamento correto para conseguir minimizar as perdas de grãos, juntamente com prejuízos financeiros e logísticos. Atualmente, a produção de grãos vem aumentando em grandes proporções se comparado com a de armazenagem estática, por diversos fatores. Por isso, neste artigo realizou-se uma estimativa da produção e armazenagem de grãos do Brasil, tendo como base os dados fornecidos pela Companhia Nacional de Abastecimento (CONAB e usando o Método dos Mínimos Quadrados. Com isso, concluiu-se que se a capacidade estática de armazenagem do país continuar a crescer em proporções menores do que a de produção, haverá um déficit cada vez maior de capacidade estática.

Rendimento de feijão e de grão-de-bico em função de fosfato solúvel aplicado em covas ou na linha de semeadura

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M. Voss

1998-03-01

Full Text Available Entre os macronutrientes, o fósforo é o que com maior freqüência proporciona aumento na produtividade das culturas. Tem-se demonstrado que a obtenção de nitrogênio por algumas das simbioses rizóbio-leguminosas exige teores maiores de fósforo do que a planta adubada com nitrogênio. Visando aumentar a eficiência no aproveitamento de fósforo no solo sem incrementar a dose de adubação, testaram-se modos de localização de adubo com fosfato solúvel para as culturas de feijão e de grão-de-bico. O feijão, em ensaio instalado em Jaguapitã (PR, foi semeado, em outubro de 1986, em um Latossolo Vermelho-Escuro com 113 g kg-1 de argila e 2,2 mg dm-3 de P. O adubo fosfatado foi distribuído a 7 cm, e as sementes a 3 cm de profundidade, ambos no sulco de semeadura. Comparou-se a adubação no sulco com a adubação em covas, em doses de 50 e de 100 kg ha-1 de P2O5, como superfosfato triplo (SFT. Incluiu-se um tratamento extra com 25 kg ha-1 de P2O5 em covas, além de testemunha sem adubação fosfatada. O feijão foi semeado em covas. O ensaio com grão-de-bico foi instalado em Londrina (PR, em junho de 1987, em um Latossolo Roxo com 760 g kg-1 de argila e 3,6 mg dm-3 de P. A adubação foi feita a 7 cm de profundidade, e a semeadura a 3 cm de profundidade. Nesse ensaio, foram testados, nas parcelas, os tratamentos: testemunha sem rizóbio, inoculação com rizóbio e sem inoculação + 30 kg ha-1 de N e, nas subparcelas, a adubação fosfatada em linha ou em covas. O grão-de-bico foi semeado em linha. Foram avaliados os teores de N, P, Zn e Mn nas folhas de feijão, bem como a produtividade e a nodulação de feijão e de grão-de-bico. Não houve nodulação em feijão e a tendência para maior nodulação em grão-de-bico, quando a adubação foi aplicada em covas, não foi significativa. Houve aumento de cerca de 40% no rendimento do feijão e de 3l% no de grão-de-bico pela adubação em covas, em relação à adubação em linha. Em

Oracle BAM 11gR1 Handbook

CERN Document Server

Wang, Pete

2012-01-01

"Oracle BAM 11gR1 Handbook" is a practical best practices tutorial focused entirely on Oracle Business Activity Monitoring. An intermediate-to-advanced guide, step-by-step instructions and an accompanying demo project will help SOA report developers through application development and producing dashboards and reports. If you are a developer/report developer or SOA Architect who wants to learn valuable Oracle BAM best practices for monitoring your operations in real time, then "Oracle BAM 11gR1 Handbook" is for you. Administrators will also find the book useful. You should already be comfortabl

Instrumentación y caracterización de disipadores térmicos

OpenAIRE

Martínez Nicolás, Iván Ángel

2015-01-01

Los objetivos de este TFG son: 1. Desarrollo de una instalación que permita caracterizar los disipadores de calor. 2. Caracterización de células Peltier, elaboración de curvas de funcionamiento. 3. Caracterización de los disipadores mediante toma de temperaturas por contacto y mediante termometría infrarroja. 4. Elaboración de curvas, gráficas y correlaciones bajo diferentes condiciones de funcionamiento. Escuela Técnica Superior de Ingeniería Industrial Universidad Politécnica de Carta...

Factores a tener en cuenta en la granulación de crudos para la fabricación de cemento

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Tonry, J. Richard

1960-12-01

Full Text Available Not availableEl estudio de los gránulos preparados con los crudos en tambores o artesas, así como aquellos nodulizados naturalmente en los hornos de vía húmeda, es reciente. Pero también puede decirse que, hasta la fecha se han estudiado con poco detenimiento en la Industria del cemento americana. En este trabajo se exponen y analizan los ensayos laboratorio de crudos procedentes de fábricas que usan nódulos en su proceso natural o por vía de experimentación. La granulación de crudos secos es necesaria en el uso de hornos del tipo de parrilla (Lepol, por ejemplo y puede practicarse también para preparar la alimentación para otros hornos rotatorios de vía seca. Los resultados varían con los diferentes crudos, en lo que se refiere al grado de perfección, para conseguir unos gránulos satisfactorios. La producción de nódulos húmedos no es difícil, como se evidencia por los resultados obtenidos con cinco crudos sin embargo, una vez secos, los gránulos procedentes de diferentes crudos varían mucho en sus propiedades. Dichos nódulos se ensayaron en capacidad bajo carga y en su resistencia a la abrasión en un amplio intervalo de temperaturas, pareciendo ser el más importante el ensayo de resistencia a la abrasión. En algunos casos, los aditivos químicos mejoran los nódulos. Las propiedades mineralógicas de los crudos tienen un efecto pronunciado sobre la consistencia del gránulo una vez seco. En este estudio se emplearon la difracción por rayos X y el análisis térmico diferencial.

Components of attitudes toward the inclusion of students with disabilities in physical education in the ATIPDPE-GR instrument for Greek physical educators [Názory na začlenění studentů s postižením do hodin tělesné výchovy v nástroji ATIPDPE-GR pro řecké učitele tělesné výchovy

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Martin Kudláček

2010-12-01

Full Text Available BACKROUND: Over the last decade the idea of the inclusion of students with disabilities and special educational needs (SEN in general schools has become increasingly the focus of national and international policies in Greece. An important factor that affects the success of inclusion is attitude and the theory of planned behavior (TPB provides a useful framework for the study of attitudes toward people with disabilities. OBJECTIVE: The purpose of the study was to examine the structure of the attitudinal scale, modified for Greece, of the Attitudes Toward Inclusion of Individuals with Physical Disabilities in Physical Education - Greece (ATIPDPE-GR, an instrument based on the theory of planned behavior (TPB of Ajzen (2000, aiming to measure Greek physical educators' attitudes. METHODS: Participants were 155 physical educators (85 females and 70 males with a mean age of 37.68 years teaching either the physical education (PE course or the Olympic & Paralympic education (O & PE course in seven different prefectures of Greece. RESULTS: Based on the one way ANOVA, the attitudinal scale of ATIPDPE-GR measures two psychological properties (components. Two components, which come from a principal component analysis, explain more than 42% of the variance. The two components are: a positive outcomes for students and b negative outcomes for teachers and students. CONCLUSIONS: Our present results indicate that the ATIPDPE-GR can be a reliable instrument that measures PE teachers' attitudes and that the theory of planned behavior can provide a sound theoretical framework for the study of the attitudes of physical educators.[VÝCHODISKA: Za poslední dekádu myšlenka začlenění studentů s postižením a speciálními vzdělávacími potřebami (SVP do všeobecných škol v Řecku nabývá na významu v rámci národní a mezinárodní politiky. Důležitý faktor, který podmiňuje úspěch tohoto začlenění, je postoj k této otázce a teorie pl

Radioterapia de intensidade modulada (IMRT para pacientes do SUS: análise de 508 tratamentos em dois anos de instalação da técnica

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Harley Francisco de Oliveira

2014-12-01

Full Text Available Objetivo: A oferta de radioterapia de alta tecnologia para população atendida pelo Sistema Único de Saúde (SUS é limitada, por não pertencer ao rol de procedimentos e, muitas vezes, pela capacidade instalada frente à demanda e dificuldade de retenção de recursos humanos especializados. Dessa forma, o acesso à radioterapia de intensidade modulada (IMRT é restrito a poucos serviços no Brasil. Pretendemos apresentar as características dos primeiros 508 tratamentos de IMRT durante os primeiros anos de instalação da técnica em um hospital universitário. Materiais e Métodos: Foram analisados 508 tratamentos de IMRT, de maio de 2011 a setembro de 2013, que completaram a radioterapia. A técnica empregada foi multilâminas estático. Resultados: De um total de 4.233 pacientes tratados no período, 12,5% realizaram IMRT. As principais indicações foram para crânio, cabeça e pescoço, e próstata. Aproximadamente 30% das radioterapias de crânio e 50% das de próstata foram por IMRT. A toxicidade total foi 4%. Conclusão: Em razão das restrições de acesso à radioterapia e da não cobertura deste procedimento, as indicações de IMRT para pacientes do SUS devem ser apoiadas nos protocolos clínicos das instituições em acordo com sua realidade, com especial atenção à redução da toxicidade.

Glyphosate efficacy on sourgrass biotypes with suspected resistance collected in GR-crop fields

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Hellen Martins da Silveira

2017-11-01

Full Text Available In Brazil, infestations of crop areas with glyphosate-resistant (GR sourgrass (Digitaria insularis (L. Fedde biotypes has risen significantly, increasing crop production costs. Glyphosate efficacy on three biotypes (GO, BA and MT of sourgrass with suspected resistance was evaluated. A susceptible biotype (MG was used as the control. The results confirmed that the MG and GO biotypes were susceptible to glyphosate (control > 90%. The MG biotype exhibited growth reduction and mortality by 50% (GR50 and LD50, respectively with mean glyphosate doses of 243.7 and 431.6 g ae ha-1. The resistance index of the biotypes with suspected resistance ranged from 2.8 to 6.1 in relation to GR50 and between 1.4 to 26.7 in relation to LD50. The glyphosate susceptibility ranking of the sourgrass biotypes was MG < GO < MT < BA. The MT and BA biotypes demonstrated high glyphosate resistance levels, and the GO biotype had a high potential to develop resistance. Farmers should avoid the application of glyphosate overdoses to minimize the selection pressure on weeds.

Determination of correction and conversion factor of exposure rate generated Gamma spectrometer GR-320 to Victoreen data

International Nuclear Information System (INIS)

Supardjo-AS; Mappa, Djody-Rachim; Nasrun-Syamsul; Syamsul-Hadi

2000-01-01

Exposure rate data of Muria Peninsula were generated from Victoreen-491 measurement and calculation of radioelement content in soil which were measured by Exploranium GR-320, using IAEA formula. However those data are not be comparable so the exposure rate calculated from Gamma Spectrometer data necessarily to be corrected. The correction factor was determinate by measuring the exposure rate of at the NMDC's back yard selected location using Victoreen-491 and Gamma Spectrometer Exploranium GR-320 . Correction factor was created by comparing mean exposure rate data that calculated from 30 data measured by Gamma Spectrometer instrument and to those Victoreen's exposure rate. Conversion factor was gained from comparing of total count data of Gamma Spectrometer Exploranium GR-320 to Victoreen's exposure rate data. The correction factor of Exploranium GR-320's exposure rate is 0.34 μR/hours, and the conversion factor of total count is 0.0092 μR/hours per c/m. Deviation Victoreen 491 = 4.7 % and Gamma Spectrometer Exploranium GR-320 8.6 %

Aplicación de la realidad virtual en la enseñanza de la ingeniería de construcción

OpenAIRE

Sánchez Botero, Tatiana

2014-01-01

El presente trabajo describe los procedimientos y resultados de la investigación, Implementación de la realidad virtual en la enseñanza de la ingeniería de la construcción, que se realizó con el propósito de explorar las posibilidades que ofrece las tecnologías avanzadas de visualización, tanto de conceptos gráficos como de proyectos, a partir de las herramientas de modelado virtual BIM 3D y 4D y la creación de ambientes y modelos de realidad virtual inmersiva, como ayudas en el proceso de...

The cystic-fibrosis-associated ΔF508 mutation confers post-transcriptional destabilization on the C. elegans ABC transporter PGP-3

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Liping He

2012-11-01

Membrane proteins make up ∼30% of the proteome. During the early stages of maturation, this class of proteins can experience localized misfolding in distinct cellular compartments, such as the cytoplasm, endoplasmic reticulum (ER lumen and ER membrane. ER quality control (ERQC mechanisms monitor folding and determine whether a membrane protein is appropriately folded or is misfolded and warrants degradation. ERQC plays crucial roles in human diseases, such as cystic fibrosis, in which deletion of a single amino acid (F508 results in the misfolding and degradation of the cystic fibrosis transmembrane conductance regulator (CFTR Cl– channel. We introduced the ΔF508 mutation into Caenorhabditis elegans PGP-3, a 12-transmembrane ABC transporter with 15% identity to CFTR. When expressed in intestinal epithelial cells, PGP-3wt was stable and efficiently trafficked to the apical plasma membrane through a COPII-dependent mechanism. However, PGP-3ΔF508 was post-transcriptionally destabilized, resulting in reduced total and apical membrane protein levels. Genetic or physiological activation of the osmotic stress response pathway, which causes accumulation of the chemical chaperone glycerol, stabilized PGP-3ΔF508. Efficient degradation of PGP-3ΔF508 required the function of several C. elegans ER-associated degradation (ERAD homologs, suggesting that destabilization occurs through an ERAD-type mechanism. Our studies show that the ΔF508 mutation causes post-transcriptional destabilization and degradation of PGP-3 in C. elegans epithelial cells. This model, combined with the power of C. elegans genetics, provides a new opportunity to genetically dissect metazoan ERQC.

Alimentación del pez insectívoro neotropical Creagrutus bolivari (Pisces: Characidae según los métodos gráfico y de importancia relativa

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Mario Ortaz

2006-12-01

Full Text Available Se estudió la alimentación de un pez neotropical (Creagrutus bolivari usando diferentes métodos: el método gráfico de Cortés (1997 y dos índices de importancia relativa (George y Hadley, 1979 (% RIi y Cortés, 1997 (% IRIi. Sólo las presas discretas (invertebrados acuáticos y terrestres se emplearon en el análisis de dieta. Se estimó ara cada ítem, las frecuencias de aparición (% A, numérica (% N y gravimétrica (% G. Se analizó un total de 240 ejemplares (intervalo de talla desde 25.3 hasta 64.7 mm de longitud estándar. Para valores de % A > 50 %, el % IRIi resultó mayor al obtenido para el % RIi, con una tendencia opuesta (hasta 130 veces para valores de % A por debajo del 50 %. El % IRIi sobreestimó la importancia relativa de las presas para valores altos de % A, mientras que subestimó la importancia relativa de las presas para valores bajos de % A y mostró un comportamiento no lineal a medida que varió el % A. Las variables empleadas en el método gráfico de Cortés son insuficientes para evaluar la estrategia alimentaria del depredador (generalismo-especialismo. De este modo, se sugiere incluir otras variables como el ancho de nicho trófico poblacional e individual así como un adecuado registro de campo. Es necesario un amplio registro de campo para clasificar a las presas como escasa o dominante de acuerdo a la clasificación de Cortés. Los índices compuestos que incluyen las variables: masa, número y aparición proporcionan una descripción más precisa de la dieta y permiten realizar estudios comparativos. El análisis gráfico es fácil de interpretar y ayuda a evaluar aspectos como la importancia de la presa y la estrategia alimentaria del depredadorThe diet of the neotropical insectivorous fish Creagrutus bolivari (Pisces: Characidae according to the "graphic" and "relative importance" methods. The diet of a neotropical fish species (Creagrutus bolivari was studied using different methods: the Cortés 1997

La caricatura, en el periodismo gráfico del nuevo siglo

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Lic. María Ximena Ávila

2002-01-01

Full Text Available Este trabajo es parte de una investigación que se propone abordar el estudio de las formas actuales de la caricatura en aquellos textos diseñados por el humorista Nik (Cristian Dzwanik para el diario La Nación de Argentina, en el periodo 2000 – 2001.Tal estudio se fundamenta en una investigación histórico-periodística que da cuenta de las condiciones socio-culturales, las luchas políticas y la participación de los sujetos sociales en la historia Argentina actual.La caricatura aparece en el periodismo gráfico en el siglo XIX aplicado a la crítica de las instituciones sociales, personajes y sucesos de la vida política y cultural.

Interacción multimodal con espacios virtuales

OpenAIRE

Olmedo Rodríguez, Héctor

2014-01-01

Esta tesis aborda el problema de definir un lenguaje de marcas para modelar escenas, comportamiento e interacción basándonos en una filosofía de integración de componentes de aplicaciones de interacción multimodal en entornos gráficos 3D en base a la metáfora de película cinematográfica interactiva. Se reutilizan lenguajes de marcas ya definidos para describir gráficos, interacción gráfica e interacción vocal. Con la definición de este lenguaje se propone un marco común para desarrollar aplic...

Ungdomsselvmord og moderniseringsproblemer blandt inuit i Grønland

DEFF Research Database (Denmark)

Thorslund, Jørgen

Undersøgelse fra Det grønlandske Forebyggelsesråds projekt vedrørende ungdomsselvmord, der ud fra kulturelle, sociale og psykologiske problemaspekter belyser årsagerne til selvmord blandt unge grønlændere og bringer forslag til forebyggelsesinitiativer, [...] der kan mindske antallet af selvmord....

Santiago Martínez Delgado, pionero del diseño gráfico colombiano: una reseña de su vida y obra

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Diego Giovanni Bermúdez Aguirre

2017-06-01

Full Text Available Hablar del diseño gráfico en Colombia como profesión autónoma es aproximarse a una historia todavía en construcción, dada la juventud de este espacio de conocimiento, el cual dio sus primeros pasos solo hasta principios del siglo XX, debido al desarrollo industrial que vino a definir un nuevo lenguaje de producción, estético y comunicativo que ahora se llama “diseño”. Este texto pretende acercarse a la vida de Santiago Martínez Delgado, uno de los primeros hombres que con su obra definió, en el contexto colombiano, los rumbos de una nueva forma de expresión y comunicación: el diseño gráfico. Se intenta comprender el carácter innovador presente en la vida y obra de este diseñador colombiano, desde la ciencia histórica a partir de la condición de lugar de producción, acercamiento al tiempo histórico como reconstrucción o representación de un presente por medio de un proceso de ficcionalización, el cual edifica y evidencia una ruptura temporal entre el pasado, asumido como espacio de experiencia, y el ahora (presente, constituido a partir de una visión prospectiva de la vida en el futuro, horizonte de expectativa.

Degradabilidade ruminal in situ da matéria seca e proteína bruta do farelo e dos grãos de soja extrusados

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Marcelo Landim Brisola

1999-01-01

Full Text Available Três novilhas mestiças Holandesas, dotadas de cânulas ruminais, foram utilizadas para comparar as taxas de degradabilidade ruminal da matéria seca e proteína bruta de três tratamentos: A farelo de soja; B grão de soja semi-integral extrusado; e C grão de soja integral extrusado, através da técnica de sacos de náilon in situ. O delineamento utilizado foi inteiramente casualizado, considerando as variáveis tratamentos, animais e repetições. Os resultados mostraram que a degradabilidade ruminal dos grãos de soja integrais ou semi-integrais e extrusados foi menor do que a degradabilidade ruminal da matéria seca e proteína do farelo de soja. Também ficou evidente que a retirada prévia de parte de gordura dos grãos (grãos de soja semi-integrais provocou diminuição na degradabilidade ruminal.

Fungos associados a grãos de café (Coffea arabica L. beneficiados no sudoeste da Bahia

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Gabriel Fernandes Pinto Ferreira

2011-09-01

Full Text Available Diversos fatores podem interferir na qualidade do café, especialmente aqueles relacionados às etapas pós-colheita de processamento e secagem. Algumas espécies de fungos podem se associar a grãos de café durante a pós-colheita, podendo ocasionar alterações indesejáveis. O objetivo deste estudo foi avaliar a influência dos processamentos via seca (natural, seco em terreiro de terra, e via úmida (despolpado, seco em terreiro de cimento, tradicionalmente empregados na região sudoeste da Bahia, na incidência de fungos em grãos de café beneficiados produzidos na safra 2007/2008. O experimento consistiu de 4 tratamentos: a café natural de Barra do Choça; b café natural de Encruzilhada; c café despolpado de Barra do Choça e d café despolpado de Encruzilhada; e 5 repetições. Foram coletadas 20 amostras de grãos de café oriundas de diferentes propriedades cafeeiras nestes municípios. Os resultados obtidos foram avaliados pelo teste de médias t de Bonferroni a 5% de probabilidade. Houve diferença estatística significativa entre os tratamentos analisados para a infestação fúngica. Os gêneros detectados foram: Aspergillus, Penicillium e Fusarium, sendo que o gênero Aspergillus foi o de maior incidência, no qual foram identificadas oito espécies: Aspergillus ochraceus, A. niger, A. flavus, A. foetidus, A. tubingensis, A. auricomus, A. sojae e A. oryzae. Foi detectada a maior incidência de fungos em grãos de café oriundos de processamento natural do que de processamento despolpado.

Erklärung der individuellen Existenzgründungsabsicht: Die 'theory of planned behavior' als sozialpsychologisches Modell im Gründungskontext

OpenAIRE

Tegtmeier, Silke

2006-01-01

Mittels einer empirischen Untersuchung (n=208) bei Lüneburger Studierenden wird Ajzens 'Theory of Planned Behavior' - eine einschlägige Theorie zur Erklärung spezifischen Verhaltens- auf die Erklärung der individuellen Gründungsabsicht angewendet. Im Anschluss an die Darlegung des Forschungsansatzes werden Ergebnisse der Untersuchung besprochen. Hierarchische Regressionsanalysen zeigen, dass Einstellung, sozialer Druck und wahrgenommene Verhaltenskontrolle maßgeblich zur Schätzung der Gründun...

Los organizadores gráficos: un aprendizaje significativo desde una perspectiva constructivista como propuesta didáctica para la enseñanza de los conceptos de la química abordados en la educación media secundaria

OpenAIRE

Arango Gómez, René Osvaldo

2014-01-01

Resumen: Las experiencias de aula del autor en la enseñanza de la química en educación media de bachillerato, teniendo como estrategia cognitiva los esquemas, tablas y otros Organizadores Gráficos, se teorizaron en postulados constructivistas que para la pedagogía aportan autores como Gowin, Ausubel, Piaget, Kelly, Vigotsky, Miller, Paivio, Johnson-Laird, Vergnaud, Novak y otros, que enfatizan como dentro de las teorías constructivistas del aprendizaje, los organizadores gráficos podrían s...

Aplicação aérea de fungicidas com diferentes equipamentos e volumes sobre a produtividade, qualidade de grãos e controle de doenças em arroz irrigado

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Tânia Bayer

2014-01-01

Full Text Available Os tratamentos fitossanitários na cultura do arroz irrigado geralmente são realizados via aplicação aérea. Por isso, o trabalho objetivou avaliar a produtividade, qualidade do grão e incidência de doenças em arroz da cultivar 'Puitá Inta CL' através da aplicação dos fungicidas Azoxistrobina e Difenoconazol com bicos defletores, 20 e 30L ha-1, bicos cônicos 20 e 30L ha-1 e atomizadores rotativos de disco 10 e 15L ha-1. Os tratamentos realizados com atomizador rotativo de disco 10L ha-1 e bico cônico 30L ha-1, receberam uma segunda aplicação 15 dias após. Os parâmetros avaliados foram os níveis de doenças foliares, peso de mil grãos, número de grãos por panícula, patologia de sementes, renda e rendimento. Não se verificou nenhuma diferença entre os tratamentos em nível de campo, entretanto, as avaliações pós-colheita revelaram importante controle dos fungos Fusarium sp., Gerlachia sp. e Bipolaris sp.

ESTUDIO DEL EFECTO DE LA ISOTERMA EN EL PROCESO DE SÍNTESIS DEL COMPUESTO DE ESTRONCIO Sr4Al6O12SO4 POR REACCIÓN EN ESTADO SÓLIDO

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José Rodríguez-García

2012-01-01

Full Text Available Se estudió el efecto de la isoterma en la síntesis del compuesto de estroncio Sr 4 Al 6 O 12 SO 4 por reacción en estado sólido. Se conformaron (100MPa gránulos a partir de la mezcla 3:3:1 molar de SrCO 3 , Al 2 O 3 y SrSO 4 , respectivamente. Las muestras fueron tratadas térmicamente a temperaturas de 800, 900, 1000, 1100 y 1200°C por periodos de 4, 6, 8 y 10 horas. Las muestras, en presentación de polvo y pastilla, fueron analizadas por ATG, ATD, DRX y MEB, desde temperatura ambiente ha sta los 1200°C. Los resultad os de análisis térmico señalan que el rango de formación del compuesto de estroncio Sr 4 Al 6 O 12 SO 4 es entre los 800 y 1200°C. Por otro lado, de acuerdo a los patrones de difr acción de rayos X, la formación del mismo se favorece al incrementarse la isoterma del tratamiento térmico. Existen dos fases meta-estables presentes durante el proceso antes mencionado, las mismas que son observadas en el MEB.

VALE QUANTO PESA: o que leva(m mulheres grávidas à prisão?

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Heloisa Vieira Simões

2017-11-01

Full Text Available O exponencial crescimento do número de mulheres encarceradas no Brasil não mudou o contexto de invisibilidade em que vivem. Diante de tal silêncio, e tendo a percepção de que é em face do feminino e de seu corpo que o sistema de justiça criminal parece expressar sua mais perversa atuação, o Projeto Mulheres pelas Mulheres se propôs a dar voz e visibilidade a essas mulheres. A partir de uma série de entrevistas – com as próprias internas e com as mulheres que visitavam presos nas penitenciárias de Piraquara-PR – foi possível traçar um perfil da mulher encarcerada no Paraná. Entretanto, chamou a atenção a expressiva quantidade de mulheres grávidas e com bebês dentro do sistema. Assim, tendo como base uma epistemologia feminista, foi possível perceber, através dos relatos e de informações a respeito da visita, da revista e das circunstâncias da prisão de determinadas mulheres, um padrão, uma série de histórias repetidas. Mulheres grávidas que, nas filas para a visita, recebem ofertas razoáveis de dinheiro em troca de um serviço, cujo sucesso já estaria acertado com os responsáveis pela revista. Em um instante, porém, tornam-se, para o sistema de justiça criminal, traficantes. Mulheres-traficantes que trazem no ventre a paradoxal contradição de serem mulheres-traficantes-grávidas, subvertendo a ordem de gênero e os papeis naturalmente estabelecidos, caracterizando aquilo que, simbolicamente, não se admite: que uma criminosa seja, também, mãe.

Curcumin/poly(2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline) formulation: An improved penetration and biological effect of curcumin in F508del-CFTR cell lines.

Science.gov (United States)

Gonçalves, Cristine; Gomez, Jean-Pierre; Même, William; Rasolonjatovo, Bazoly; Gosset, David; Nedellec, Steven; Hulin, Philippe; Huin, Cécile; Le Gall, Tony; Montier, Tristan; Lehn, Pierre; Pichon, Chantal; Guégan, Philippe; Cheradame, Hervé; Midoux, Patrick

2017-08-01

Neutral amphiphilic triblock ABA copolymers are of great interest to solubilize hydrophobic drugs. We reported that a triblock ABA copolymer consisting of methyl-2-oxazoline (MeOx) and tetrahydrofuran (THF) (MeOx 6 -THF 19 -MeOx 6 ) (TBCP2) can solubilize curcumin (Cur) a very hydrophobic molecule exhibiting multiple therapeutic effects but whose insolubility and low stability in water is a major drawback for clinical applications. Here, we provide evidences by flow cytometry and confocal microscopy that Cur penetration in normal and ΔF508-CFTR human airway epithelial cell lines is facilitated by TBCP2. When used on ΔF508-CFTR cell lines, the Cur/TBCP2 formulation promotes the restoration of the expression of the CFTR protein in the plasma membrane. Furthermore, patch-clamp and MQAE fluorescence experiments show that this effect is associated with a correction of a Cl - selective current at the membrane surface of F508del-CFTR cells. The results show the great potential of the neutral amphiphilic triblock copolymer MeOx 6 -THF 19 -MeOx 6 as carrier for curcumin in a Cystic Fibrosis context. We anticipate that other MeOx n -THF m -MeOx n copolymers could have similar behaviours for other highly insoluble therapeutic drugs or cosmetic active ingredients. Copyright © 2017 Elsevier B.V. All rights reserved.

Caracterização microestrutural de soldas dissimilares dos aços ASTM A-508 e AISI 316L Characterization of dissimilar metal weld between low alloy steel ASTM A-508 and 316L stainless steel

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Luciana Iglésias Lourenço Lima

2010-06-01

Full Text Available As soldas dissimilares (dissimilar metal welds - DMWs são utilizadas em diversos segmentos da indústria. No caso específico de usinas nucleares, tais soldas são necessárias para conectar tubulações de aço inoxidável com componentes fabricados em aços baixa liga. Os materiais de adição mais utilizados neste tipo de solda são as ligas de níquel 82 e 182. Este trabalho consistiu na soldagem de uma junta dissimilar de aço baixa liga ASTM A-508 G3 e aço inoxidável austenítico AISI 316L utilizando as ligas de níquel 82 e 182 como metais de adição. A soldagem foi realizada manualmente empregando os processos de soldagem ao arco SMAW (Shielded Metal Arc Welding e GTAW (Gas Tungsten Arc Welding. Os corpos de prova foram caracterizados microestruturalmente utilizando-se microscópio óptico e microscópio eletrônico de varredura com microanálise por dispersão de energia de raios X (EDS e ensaios de microdureza Vickers. Observou-se uma microestrutura constituída de dendritas de austenita com a presença de precipitados com formas e dimensões definidas pelo aporte térmico e pela direção de soldagem. Não houve variação significativa da dureza ao longo da junta soldada, demonstrando a adequação dos parâmetros de soldagem utilizados.The dissimilar metal welds (DMWs are used in several areas of the industries. In the nuclear power plant, this weld using nickel alloy welding wires is used to connect stainless steel pipes to low alloy steel components on the reactor pressured vessels. The filler materials commonly used in this type of weld are nickel alloys 82 and 182.. In this study, dissimilar metal welds composed of low alloy steel ASTM A-508 G3, nickel alloys 82 e 182 as weld metals, and austenitic stainless steel AISI 316L were prepared by manual shielded metal arc welding (SMAW and gas tungsten arc welding techniques (GTAW. Samples were microstructural characterized by optical microscopy and scanning electron microscopy

Processamento de grãos de milho para ruminantes: Digestibilidade aparente e "in situ"

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Carlos de Sousa Lucci

2008-02-01

Full Text Available Seis carneiros machos Suffolk, com pesos de 35 a 40 kg e idades de 2 anos, dotados de cânulas de rúmen, foram utilizados para comparar dietas contendo milho em grãos processados para diferentes tamanhos de partículas: A grosseiramente quebrado B grosseiramente moído (quirera grossa C finamente moído (fubá. O delineamento empregado foi o "change-over", com dois grupos de três animais em período experimental de 84 dias. A ração era composta de farelo de soja (14 %, milho em grãos (26 % e feno (60 %, medindo-se digestibilidade total e "in situ" do milho e do feno parâmetros ruminais: pH, N-NH3 e cinética de líquidos. Os resultados mostraram menores taxas de degradabilidade da matéria seca e proteína bruta do milho quando fornecido grosseiramente quebrado. Não ocorreram influências dos tratamentos sobre a fibra do feno ou sobre parâmetros ruminais. Concluiu-se que, no interior do rúmen, grãos de milho finamente moídos tiveram maior digestibilidade sem provocar alterações na digestão da fibra.

Realocação de nitrogênio e de biomassa para os grãos, em trigo submetido a inoculação de Azospirillum Reallocation of nitrogen and biomass to the seeds in wheat inoculated with Azospirillum bacteria

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AGOSTINHO DIRCEU DIDONET

2000-02-01

Full Text Available Estudou-se, em condições de campo, o efeito de inoculante turfoso em pó contendo bactérias do gênero Azospirillum no rendimento de grãos e na remobilização de N e de biomassa para os grãos de trigo (Triticum aestivum L., cultivar Embrapa 16. Usaram-se como inoculantes, a estirpe de Azospirillum brasilense 245 e o isolado 10 de Azospirillum lipoferum. Em cada tratamento de inoculação, e também sem inoculação, aplicaram-se diferentes doses de N em diferentes estádios de desenvolvimento das plantas, distribuídos em blocos ao acaso com parcelas subdivididas. Na antese e na maturação fisiológica, avaliaram-se o acúmulo de massa seca e N total nas diferentes partes da planta. Na colheita, além do rendimento de grãos, avaliaram-se também o índice de colheita para biomassa e para N, os principais componentes do rendimento e o teor de N total de grãos. Os resultados ainda preliminares evidenciaram que, mesmo não havendo efeito da inoculação no rendimento de grãos, houve um melhor alocamento de N e de biomassa para os grãos, resultando em maior massa de mil grãos e em menor quantidade de N restante na palha das plantas na maturação fisiológica. Esses efeitos resultaram de um menor número de espigas m-2, provavelmente devido à morte de afilhos, fator que determinou maior disponibilidade de N e de biomassa às espigas e grãos restantes.The effect of inoculating wheat (Triticum aestivum L. seeds, cultivar Embrapa 16, with powder peat inoculant containing Azospirillum bacteria on yield and remobilization of nitrogen and biomass was studied under field conditions. The strain of Azospirillum brasilense 245 and the isolate 10 of Azospirillum lipoferum were used as inoculants. Different rates of nitrogen were applied at varying stages of plant growth for each inoculated and non-inoculated treatment, distributed in blocks at random with split plots. The accumulation of dry matter and total nitrogen in plant parts was evaluated

Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del.

Science.gov (United States)

Taylor-Cousar, Jennifer L; Munck, Anne; McKone, Edward F; van der Ent, Cornelis K; Moeller, Alexander; Simard, Christopher; Wang, Linda T; Ingenito, Edward P; McKee, Charlotte; Lu, Yimeng; Lekstrom-Himes, Julie; Elborn, J Stuart

2017-11-23

Combination treatment with the cystic fibrosis transmembrane conductance regulator (CFTR) modulators tezacaftor (VX-661) and ivacaftor (VX-770) was designed to target the underlying cause of disease in patients with cystic fibrosis. In this phase 3, randomized, double-blind, multicenter, placebo-controlled, parallel-group trial, we evaluated combination therapy with tezacaftor and ivacaftor in patients 12 years of age or older who had cystic fibrosis and were homozygous for the CFTR Phe508del mutation. Patients were randomly assigned in a 1:1 ratio to receive either 100 mg of tezacaftor once daily and 150 mg of ivacaftor twice daily or matched placebo for 24 weeks. The primary end point was the absolute change in the percentage of the predicted forced expiratory volume in 1 second (FEV 1 ) through week 24 (calculated in percentage points); relative change in the percentage of the predicted FEV 1 through week 24 (calculated as a percentage) was a key secondary end point. Of the 510 patients who underwent randomization, 509 received tezacaftor-ivacaftor or placebo, and 475 completed 24 weeks of the trial regimen. The mean FEV 1 at baseline was 60.0% of the predicted value. The effects on the absolute and relative changes in the percentage of the predicted FEV 1 in favor of tezacaftor-ivacaftor over placebo were 4.0 percentage points and 6.8%, respectively (Pcystic fibrosis and were homozygous for the CFTR Phe508del mutation. (Funded by Vertex Pharmaceuticals; EVOLVE ClinicalTrials.gov number, NCT02347657 .).

Investigation of fatigue crack growth in SA508-2 in a 2880C PWR environment by a constant δK test method

International Nuclear Information System (INIS)

Van Der Sluys, W.A.; DeMiglio, D.S.

1983-01-01

Fatigue crack growth experiments using a constant δK test technique were conducted on three 50.8 mm thick compact fracture specimens of SA508-2 in a 288 0 C simulated PWR water environment. Alternating stress intensity factor (δK) values were investigated in the range 16.5 to 44 MPa√m at sinusoidal loading frequencies ranging from 10 to .017 Hz (1 cpm) and R ratios 0.03 to 0.72. For a given δK and frequency, δK was held constant to within 1%. A steady-state rate of crack growth per cycle of stress (da/dN) was determined for each test condition. Over a typical crack extension of 1.3 mm, the crack growth rate in many cases was a constant. As many as 14 separate experiments were conducted on a single specimen. There was no influence of prior loading history or crack length on the crack growth rate. It was found that the crack growth rate was controlled by the δK, frequency, and R ratio of the test. Large changes in the crack growth rate did not occur as the frequency of loading was decreased from >1 Hz to .017 Hz (1 cpm). As compared to high frequency results (>1 Hz) the crack growth rate increased slightly at 1 cpm for δK > 22 MPa√m and decreased slightly for δK < 22 MPa√m. At 1 cpm the R ratio was observed to influence the crack growth rate; however, the magnitude of this effect was not well-defined

Effect of Cutting Parameters on Thrust Force and Surface Roughness in Drilling of Al-2219/B4C/Gr Metal Matrix Composites

Science.gov (United States)

Ravindranath, V. M.; Basavarajappa, G. S. Shiva Shankar S.; Suresh, R.

2016-09-01

In aluminium matrix composites, reinforcement of hard ceramic particle present inside the matrix which causes tool wear, high cutting forces and poor surface finish during machining. This paper focuses on effect of cutting parameters on thrust force, surface roughness and burr height during drilling of MMCs. In the present work, discuss the influence of spindle speed and feed rate on drilling the pure base alloy (Al-2219), mono composite (Al- 2219+8% B4C) and hybrid composite (Al-2219+8%B4C+3%Gr). The composites were fabricated using liquid metallurgy route. The drilling experiments were conducted by CNC machine with TiN coated HSS tool, M42 (Cobalt grade) and carbide tools at various spindle speeds and feed rates. The thrust force, surface roughness and burr height of the drilled hole were investigated in mono composite and hybrid composite containing graphite particles, the experimental results show that the feed rate has more influence on thrust force and surface roughness. Lesser thrust force and discontinuous chips were produced during machining of hybrid composites when compared with mono and base alloy during drilling process. It is due to solid lubricant property of graphite which reduces the lesser thrust force, burr height and lower surface roughness. When machining with Carbide tool at low feed and high speeds good surface finish was obtained compared to other two types of cutting tool materials.

Gräzin : Tagasi tähendab edasi / Igor Gräzin ; interv. Urmas Lauri

Index Scriptorium Estoniae

Gräzin, Igor, 1952-

2004-01-01

Europarlamenti kandideeriva Igor Gräzini arvates oleks Eestile olnud kasulik EL-i astumisega veel kaks-kolm aastat oodata. Euroopa Liit peaks tagasi minema aastasse 1957, kui ta oli vabakaubandusassotsiatsioon, see võimaldaks USA-ga konkureerida, väidab autor

Põhjamaade kultuurikeskus Nuuk`is Gröönimaal = Pohjoismainen kulttuurikekus, Nuuk, Grönlanti / Mikko Heikkinen, Markku Komonen

Index Scriptorium Estoniae

Heikkinen, Mikko

1993-01-01

Põhjamaade kultuurikeskuse ehitamiseks Gröönimaale Nuuḱi linna korraldati 1993.a. rahvusvaheline arhitektuurikonkurss. Artiklis on tutvustatud soome arhitektide Mikko Heikkineni ja Markku Komoneni võistlustööd

Les tumeurs malignes primitives de l’intestin grèle: Aspects cliniques et thérapeutiques de 27 patients

Directory of Open Access Journals (Sweden)

Abahssain Halima

2011-03-01

Full Text Available Les tumeurs malignes de l'intestin grèle (TMPIG sont des tumeurs rares. Elles représentent 1 à 5% de toutes les tumeurs du tube digestif. Elles sont caractérisées par une hétérogénéité anatomopathologique et une symptomatologie pauvre et non spécifique entrainant ainsi un retard diagnostic, des difficultés Thérapeutiques et donc un mauvais pronostic. Nous rapportant les caractéristiques épidémiologiques, diagnostiques et thérapeutiques ainsi que la survie des patients atteints des TMIG au sein de l’institut national d’oncologie de Rabat. Il s’agit d’une analyse rétrospective des dossiers cliniques des 27 patients ayant le diagnostic de tumeurs malignes de l’intestin grèle admis dans notre institut entre 1998 et 2002. L’âge médian était de 46 ans (15-70 ans. Le délai médian de diagnostic était de 6 mois (0-96 mois. La douleur abdominale était le symptôme le plus fréquent (77.8%. L’étude anatomopathologique a montré 63% de lymphome non Hodgkinie, 14.8% d’adénocarcinome, 7.4% de tumeur stromale, 7.4% de carcinome neuroendocrine et 7.4% de sarcome intestinal. Vingt patients (76. 9% ont eu une résection chirurgicale et 14 patients (53. 8% ont eu une chimiothérapie en fonction du stade de la maladie et du type histologique. Après un recul médian de 11.6 mois, la survie globale après 12 mois était de 44.4% et la médiane de survie était de 11.6 mois. Les tumeurs malignes de l’intestin grèle sont rares. Leur diagnostic est tardif limitant ainsi la prise en charge thérapeutique curative. Les cliniciens doivent ètre avertis des symptômes gastro-intestinaux non spécifiques

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Siim, Birte

2010-01-01

I den forløbne uge har 'burkasagen' og sagen om kønsopdelte grupper på Blågårdsskolen atter udfordret grænserne for det danske demokratis rummelighed. De to sager har vakt stor opsigt i pressen og har fremkaldt voldsomme udtalelser både fra repræsentanter for regeringen, dens støtteparti og fra t...

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