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Sample records for 8-week prospective study

  1. Pregnancy Flu Shot Protects Newborn for 8 Weeks: Study

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_159719.html Pregnancy Flu Shot Protects Newborn for 8 Weeks: Study Effectiveness ... 2016 TUESDAY, July 5, 2016 (HealthDay News) -- A flu shot during pregnancy protects newborns against the flu ...

  2. A multi-center, prospective, open-label, 8-week study of certoparin for anticoagulation during maintenance hemodialysis – the membrane study

    Directory of Open Access Journals (Sweden)

    Dorsch Oliver

    2012-06-01

    Full Text Available Abstract Background Adequate anticoagulation is prerequisite for effective hemodialysis to prevent clotting in the extracorporeal circuit. We aimed providing first data on the efficacy and safety of the low-molecular-weight heparin certoparin in this setting. Methods Multicenter, open-label, 8-week trial. Patients received a single dose of 3,000 IU certoparin i.v. with additional titration steps of 600 IU and/or continuous infusion if necessary. Results 120 patients were screened, 109 enrolled (median age 71; range 26–90 years and 106 available for efficacy analyses. The percentage of unsatisfactory dialysis results at 8 weeks due to clotting or bleeding, was 1.9% (n = 2/106; 95% confidence interval [CI] 0.23–6.65%; no major bleeding. 1.9% had moderate/severe clotting in the lines/bubble catcher and 2.8% in the dialyser at week 8. 15.7 ± 14.3% of the dialysis filters’ visual surface area was showing redness. In subgroups of patients receiving median doses of 3000 ± 0, 3000 (2400–6000 and 4200 (3000–6600 IU, plasma aXa levels at baseline, 4 and 8 weeks were 0.24 [95%CI 0.21–0.27], 0.33 [0.27–0.40] and 0.38 [0.33–0.45] aXa IU/ml at 2 h. C48h was 0.01 [0.01–0.02] aXa IU at all visits. At baseline and 4 weeks AUC0-48h was 2.66 [2.19–3.24] and 3.66 [3.00–4.45] aXa IU*h/ml. In 3.0% of dialyses (n = 83/2724 prolonged fistula compression times were documented. Eight patients (7.34% had at least one episode of minor bleeding. 4 85.3% of patients had any adverse event, 9.2% were serious without suspected drug relation; and in 32 patients a drug-relation was suspected. Conclusions Certoparin appears effective and safe for anticoagulation in patients undergoing maintenance hemodialysis.

  3. Effect of levitra on sustenance of erection (EROS): an open-label, prospective, multicenter, single-arm study to investigate erection duration measured by stopwatch with flexible dose vardenafil administered for 8 weeks in subjects with erectile dysfunction.

    Science.gov (United States)

    Shin, Y S; Lee, S W; Park, K; Chung, W S; Kim, S W; Hyun, J S; Moon, D G; Yang, S-K; Ryu, J K; Yang, D Y; Moon, K H; Min, K S; Park, J K

    2015-01-01

    To investigate the change of erection duration measured by stopwatch with flexible dose vardenafil administered for 8 weeks in subjects with erectile dysfunction (ED). Effect of levitra on sustenance of erection was an open-label, prospective, multicenter and single-arm study designed to measure the duration of erection in men with ED receiving a flexible dose of vardenafil over an 8-week treatment period. Patients were instructed to take vardenafil 10 mg 60 min before attempting the intercourse. Vardenfil could be increased to 20 mg or decreased to 5 mg concerning patients' efficacy and safety. Following the initial screening, patients entered a 4-week treatment-free run-in phase and 8-week treatment period, during which they were instructed to attempt intercourse at least four times on four separate days. A total of 95 men were enrolled in 10 centers. After the 8 weeks treatment, the mean duration of erection leading to successful intercourse was statistically superior when patients were treated with vardenafil. After an 8-week treatment, the duration of erection leading to successful intercourse was 9.39 min. There were significant benefits with vardenafil in all domains of International Index of Erectile Function. Secondary efficacy end points included success rate of penetration, maintaining erection, ejaculation and satisfaction were superior when patients were treated with vardenafil. There was a significant correlation between duration of erection with other sexual factors. Also partner's sexual satisfaction was increased with vardenafil. Most adverse events were mild or moderate in severity. Vardenafil was safe and well tolerated. Vardenafil therapy provided a statistically superior duration of erection leading to successful intercourse in men with ED with female partner. PMID:25471318

  4. Changes in Disability, Physical/Mental Health States and Quality of Life during an 8-Week Multimodal Physiotherapy Programme in Patients with Chronic Non-Specific Neck Pain: A Prospective Cohort Study

    Science.gov (United States)

    Cuesta-Vargas, Antonio Ignacio; González-Sánchez, Manuel

    2015-01-01

    Aim The aim of this study was to analyse the effect of an 8-week multimodal physiotherapy programme (MPP), integrating physical land-based therapeutic exercise (TE), adapted swimming and health education, as a treatment for patients with chronic non-specific neck pain (CNSNP), on disability, general health/mental states and quality of life. Methods 175 CNSNP patients from a community-based centre were recruited to participate in this prospective study. Intervention: 60-minute session (30 minutes of land-based exercise dedicated to improving mobility, motor control, resistance and strengthening of the neck muscles, and 30 minutes of adapted swimming with aerobic exercise keeping a neutral neck position using a snorkel). Health education was provided using a decalogue on CNSNP and constant repetition of brief advice by the physiotherapist during the supervision of the exercises in each session. Study outcomes: primary: disability (Neck Disability Index); secondary: physical and mental health states and quality of life of patients (SF-12 and EuroQoL-5D respectively). Differences between baseline data and that at the 8-week follow-up were calculated for all outcome variables. Results Disability showed a significant improvement of 24.6% from a mean (SD) of 28.2 (13.08) at baseline to 16.88 (11.62) at the end of the 8-week intervention. All secondary outcome variables were observed to show significant, clinically relevant improvements with increase ranges between 13.0% and 16.3% from a mean of 0.70 (0.2) at baseline to 0.83 (0.2), for EuroQoL-5D, and from a mean of 40.6 (12.7) at baseline to 56.9 (9.5), for mental health state, at the end of the 8-week intervention. Conclusion After 8 weeks of a MPP that integrated land-based physical TE, health education and adapted swimming, clinically-relevant and statistically-significant improvements were observed for disability, physical and mental health states and quality of life in patients who suffer CNSNP. The clinical

  5. Changes in disability, physical/mental health states and quality of life during an 8-week multimodal physiotherapy programme in patients with chronic non-specific neck pain: a prospective cohort study.

    Directory of Open Access Journals (Sweden)

    Antonio Ignacio Cuesta-Vargas

    Full Text Available The aim of this study was to analyse the effect of an 8-week multimodal physiotherapy programme (MPP, integrating physical land-based therapeutic exercise (TE, adapted swimming and health education, as a treatment for patients with chronic non-specific neck pain (CNSNP, on disability, general health/mental states and quality of life.175 CNSNP patients from a community-based centre were recruited to participate in this prospective study.60-minute session (30 minutes of land-based exercise dedicated to improving mobility, motor control, resistance and strengthening of the neck muscles, and 30 minutes of adapted swimming with aerobic exercise keeping a neutral neck position using a snorkel. Health education was provided using a decalogue on CNSNP and constant repetition of brief advice by the physiotherapist during the supervision of the exercises in each session.primary: disability (Neck Disability Index; secondary: physical and mental health states and quality of life of patients (SF-12 and EuroQoL-5D respectively. Differences between baseline data and that at the 8-week follow-up were calculated for all outcome variables.Disability showed a significant improvement of 24.6% from a mean (SD of 28.2 (13.08 at baseline to 16.88 (11.62 at the end of the 8-week intervention. All secondary outcome variables were observed to show significant, clinically relevant improvements with increase ranges between 13.0% and 16.3% from a mean of 0.70 (0.2 at baseline to 0.83 (0.2, for EuroQoL-5D, and from a mean of 40.6 (12.7 at baseline to 56.9 (9.5, for mental health state, at the end of the 8-week intervention.After 8 weeks of a MPP that integrated land-based physical TE, health education and adapted swimming, clinically-relevant and statistically-significant improvements were observed for disability, physical and mental health states and quality of life in patients who suffer CNSNP. The clinical efficacy requires verification using a randomised controlled study

  6. A multicentre weight loss study using a low-calorie diet over 8 weeks

    DEFF Research Database (Denmark)

    Papadaki, Angeliki; Linardakis, Manolis; Plada, Maria;

    2013-01-01

    The efficacy of low-calorie diets (LCDs) has not been investigated in large-scale studies or among people from different regions, who are perhaps unaccustomed to such methods of losing weight. The aim of the present study was to investigate changes in obesity measures among overweight/obese adults...... from eight European cities (from Northern, Central and Southern Europe) during the 8-week LCD phase of the DiOGenes study (2006-2007), a family-based, randomised, controlled dietary intervention....

  7. STX209 (Arbaclofen) for Autism Spectrum Disorders: An 8-Week Open-Label Study

    OpenAIRE

    Erickson, Craig A.; Veenstra-Vanderweele, Jeremy M.; Melmed, Raun D.; McCracken, James T.; Ginsberg, Lawrence D.; Sikich, Linmarie; Scahill, Lawrence; Cherubini, Maryann; Zarevics, Peter; Walton-Bowen, Karen; Carpenter, Randall L.; Wang, Paul P.; King, Bryan H.; Bear, Mark

    2013-01-01

    STX209 (arbaclofen), a selective GABA-B agonist, is hypothesized to modulate the balance of excitatory to inhibitory neurotransmission, and has shown preliminary evidence of benefit in fragile X syndrome. We evaluated its safety, tolerability, and efficacy in non-syndromic autism spectrum disorders, in an 8-week open-label trial enrolling 32 children and adolescents with either Autistic Disorder or Pervasive Developmental Disorder—Not Otherwise Specified, and a score ≥17 on the Aberrant Behav...

  8. The health-enhancing efficacy of Zumba® fitness: An 8-week randomised controlled study.

    Science.gov (United States)

    Domene, Pablo A; Moir, Hannah J; Pummell, Elizabeth; Knox, Allan; Easton, Chris

    2016-08-01

    The purpose of this study was to gain a holistic understanding of the efficacy of Zumba® fitness in a community-recruited cohort of overweight and physically inactive women by evaluating (i) its physiological effects on cardiovascular risk factors and inflammatory biomarkers and (ii) its mental health-enhancing effects on factors of health-related quality of life (HRQoL). Participants were randomly assigned to either engagement in one to two 1 h classes of Zumba® fitness weekly (intervention group; n = 10) or maintenance of habitual activity (control group; n = 10). Laboratory assessments were conducted pre- (week 0) and post-intervention (week 8) with anthropometric, physiological, inflammatory and HRQoL data collected. In the intervention group, maximal oxygen uptake significantly increased (P psychosocial health promotion context, our data suggest that Zumba® fitness is indeed an efficacious health-enhancing activity for adults. PMID:26571136

  9. Home grocery delivery improves the household food environments of behavioral weight loss participants: Results of an 8-week pilot study

    Directory of Open Access Journals (Sweden)

    Niemeier Heather M

    2007-11-01

    Full Text Available Abstract Background Household food availability is consistently linked to dietary intake; yet behavioral weight control treatment includes only minimal instruction on how to change the home environment to support dietary goals. This pilot study examined whether it is feasible to change the household food environments of behavioral weight loss participants through the use of a commercially available grocery home delivery service. Methods Overweight participants (N = 28; BMI = 31.7 ± 3.6 kg/m2; 89.3% women, 47.9 ± 9.5 years were randomly assigned to 8-weeks of standard behavioral weight loss (SBT or to SBT plus home food delivery (SBT+Home. SBT+Home participants were instructed to do their household grocery shopping via an online service affiliated with a regional supermarket chain and were reimbursed for delivery charges. Results Compared to SBT, SBT+Home produced significantly greater reductions in the total number of foods in the home (p = .01 and number of foods that were high in fat (p = .002. While the groups did not differ in 8-week weight losses, within SBT+Home there was a trend for the number of home deliveries to be associated with weight loss (p = .08. Participants reported that the home delivery service was easy to use and that it helped decrease impulse purchases and lead to healthier choices; however, few planned to continue using the service after the study. Conclusion Encouraging weight loss participants to use a commercially available online grocery ordering and home delivery service reduces the overall number of food items in the home and decreases access to high-fat food choices. More research is needed to determine whether this is a viable strategy to strengthen stimulus control and improve weight loss outcomes.

  10. Initial weight loss on an 800-kcal diet as a predictor of weight loss success after 8 weeks: the Diogenes study

    DEFF Research Database (Denmark)

    Handjieva-Darlenska, T; Handjiev, S; Larsen, Thomas Meinert;

    2010-01-01

    The purpose of this study was to investigate whether pre-treatment subject characteristics and weight change during the first weeks of a low-calorie diet (LCD) can predict weight loss outcomes at the end of a controlled 8-week weight loss period in overweight and obese adults.......The purpose of this study was to investigate whether pre-treatment subject characteristics and weight change during the first weeks of a low-calorie diet (LCD) can predict weight loss outcomes at the end of a controlled 8-week weight loss period in overweight and obese adults....

  11. Human in vivo study of the renin-angiotensin-aldosterone system and the sympathetic activity after 8 weeks daily intake of fermented milk

    DEFF Research Database (Denmark)

    Usinger, Lotte; Ibsen, Hans; Linneberg, Allan;

    2010-01-01

    Milk fermented by lactic acid bacteria is suggested to have antihypertensive effect in humans. In vitro and animal studies have established an angiotensin-converting enzyme (ACE) inhibitor effect of peptides in fermented milk. However, other modes of action must be considered, because until today...

  12. Urinary tract infections in febrile infants younger than 8 weeks of age.

    Science.gov (United States)

    Crain, E F; Gershel, J C

    1990-09-01

    In this prospective study of 442 infants younger than 8 weeks of age who attended a pediatric emergency department with temperature greater than or equal to 100.6 degrees F (38.1 degrees C), urinary tract infections (UTIs) were found in 33 patients (7.5%), 2 of whom were bacteremic. Clinical and laboratory data were not helpful for identifying UTIs. Of the 33 patients with UTIs, 32 had urinalyses recorded; 16 were suggestive of a UTI (more than five white blood cells per high-power field or any bacteria present). Of the 16 infants with apparently normal urinalysis results, three had an emergency department diagnosis suggesting an alternative bacterial focus of infection. If the physician had decided on the basis of apparently normal urinalysis results to forgo obtaining a urine culture, more than half of the UTIs would have been missed. Bag-collected specimens were significantly more likely to yield indeterminate urine culture results than either catheter or suprapubic specimens. In addition, uncircumcised males were significantly more likely to have a UTI than circumcised boys. These results suggest that a suprapubic or catheter-obtained urine specimen for culture is a necessary part of the evaluation of all febrile infants younger than 8 weeks of age, regardless of the urinalysis findings or another focus of presumed bacterial infection.

  13. a prospective comparative study

    OpenAIRE

    Jäckel, Tanja

    2011-01-01

    Objective: To examine effectiveness and safety of homoeopathic vs. conventional treatment for children with atopic eczema in usual care. In a prospective multicentre comparative observational non-randomized study 135 patients (1-14 years old, homoeopathy n=48 vs. conventional n=87) with moderate atopic eczema were included. Treatment was left to the physicians´preferences in both groups. The primary endpoint was the SCORAD (SCOring Atopic Dermatitis) after 6 months. Secondary outcom...

  14. Pain rehabilitation – outcome of an 8-week rehabilitation program

    Directory of Open Access Journals (Sweden)

    Norrefalk J.R.

    2012-10-01

    Full Text Available The prevalence of persistent pain has been estimated to be around 20-50% in a normal population. Musculoskeletal related pain is the most common form of persistent pain. In patients with persistent pain there are alterations in the peripheral as well as the central nervous system and patients develop a dysfunctional behaviour which, in many cases, leads to severe suffering for the patient. In the European countries an increasing problem has emerged consisting of more people on long-term sick-leave, increased number of early retirements and high social costs. After an 8-week structured multiprofessional rehabilitation programme at the Karolinska Institute in Stockholm, Sweden 63% of patients with long-standing non-malignant pain returned to work and half of the patients were still at work at a 6-year follow-up. Half of the patients reported pain reduction and almost half of the patients had reduced their consumption of analgesics. The rehabilitation program was estimated as economically beneficial on a society level. It is concluded that pain rehabilitation should have a multiprofessional approach. Pain rehabilitation programs are beneficial for the possibility for the patient to return to work pain and leads to pain reduction in the long run. Furthermore, they are beneficial from a socio-economical aspect.

  15. Efficacy and safety of fixed-dose combination therapy with olmesartan medoxomil and rosuvastatin in Korean patients with mild to moderate hypertension and dyslipidemia: an 8-week, multicenter, randomized, double-blind, factorial-design study (OLSTA-D RCT: OLmesartan rosuvaSTAtin from Daewoong).

    Science.gov (United States)

    Park, Jin-Sun; Shin, Joon-Han; Hong, Taek-Jong; Seo, Hong-Seog; Shim, Wan-Joo; Baek, Sang-Hong; Jeong, Jin-Ok; Ahn, Youngkeun; Kang, Woong-Chol; Kim, Young-Hak; Kim, Sang-Hyun; Hyon, Min-Su; Choi, Dong-Hoon; Nam, Chang-Wook; Park, Tae-Ho; Lee, Sang-Chol; Kim, Hyo-Soo

    2016-01-01

    The pill burden of patients with hypertension and dyslipidemia can result in poor medication compliance. This study aimed to evaluate the efficacy and safety of fixed-dose combination (FDC) therapy with olmesartan medoxomil (40 mg) and rosuvastatin (20 mg) in Korean patients with mild to moderate hypertension and dyslipidemia. This multicenter, randomized, double-blind, factorial-design study included patients aged ≥20 years with mild to moderate essential hypertension and dyslipidemia. Patients were randomly assigned to receive FDC therapy (40 mg olmesartan medoxomil, 20 mg rosuvastatin), 40 mg olmesartan medoxomil, 20 mg rosuvastatin, or a placebo. The percentage change from baseline in low-density lipoprotein cholesterol levels was compared between FDC therapy and olmesartan medoxomil, and the change from baseline in diastolic blood pressure was compared between FDC therapy and rosuvastatin 8 weeks after treatment. A total of 162 patients were included. The least square mean percentage change (standard error) from baseline in low-density lipoprotein cholesterol levels 8 weeks after treatment was significantly greater in the FDC than in the olmesartan medoxomil group (-52.3% [2.8%] vs -0.6% [3.5%], Prosuvastatin group (-10.4 [1.2] mmHg vs 0.1 [1.6] mmHg, Polmesartan medoxomil and rosuvastatin is an effective, safe treatment for patients with hypertension and dyslipidemia. This combination may improve medication compliance in patients with a large pill burden. PMID:27574399

  16. Changes in corticospinal transmission following 8 weeks of ankle joint immobilization

    DEFF Research Database (Denmark)

    Leukel, Christian; Taube, Wolfgang; Rittweger, Jörn;

    2015-01-01

    . Immobilization had no significant effects on spinal reflex measures. CONCLUSIONS: 8weeks of ankle joint immobilization was accompanied by pathway-specific modulation of corticospinal transmission. SIGNIFICANCE: It is particularly interesting that fast corticospinal projections were unaffected as these are......OBJECTIVES: Joint immobilization has previously been shown to modulate corticospinal excitability. The present study investigated changes in the excitability of distinct fractions of the corticospinal pathway by means of conditioning the H-reflex with transcranial magnetic stimulation (TMS) of the...... primary motor cortex (Hcond). This method allows assessment of transmission in fast (monosynaptic) and slow(er) (polysynaptic) corticospinal pathways. METHODS: 9 subjects underwent 8weeks of unilateral ankle joint immobilization during daytime, 7 subjects served as controls. The measures obtained before...

  17. EFFECT OF 8 WEEKS OF AEROBIC ON BODY COMPOSITION AND BLOOD PRESSURE IN POSTMENOPAUSAL WOMEN

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    Shahram Gholamrezai

    2014-10-01

    Full Text Available Aim: Nowadays increasing blood pressure is the most important risk factor of coronary, cerebral and renal vessel diseases. Epidemiological studies indicate that Physical inactivity adversely affects the blood pressure in postmenopausal women. The purpose of this study was to determine the impact of aerobic on body composition and blood pressure in postmenopausal women. Methods: 20 healthy postmenopausal women with similar age and weight were randomly devided in intervention and control groups. Subjects completed an informed consent form and health history questionnaire. The intervention group was trained in an aerobic exercise program for 8 weeks (3 sessions weekly. Weight, body fat percentage (BF%, body mass index (BMI, waist to hip ratio (WHR, Lean body mass and blood pressure (BP were measured in the beginning and the end of the study for all of the subjects. Data were analyzed by the Paired t-test and independent t- test. Results: The results showed that BF% , WHR, BMI decreased and Lean body mass increased significantly in training group after 8 weeks training (P0.05. Conclusions: It seems that a period of aerobic training for 8 weeks can be effective as a non-pharmacological treatment strategy for improvement some physical fitness and body composition indexes, blood pressure in postmenopausal women.

  18. Efficacy and safety of fixed-dose combination therapy with olmesartan medoxomil and rosuvastatin in Korean patients with mild to moderate hypertension and dyslipidemia: an 8-week, multicenter, randomized, double-blind, factorial-design study (OLSTA-D RCT: OLmesartan rosuvaSTAtin from Daewoong)

    Science.gov (United States)

    Park, Jin-Sun; Shin, Joon-Han; Hong, Taek-Jong; Seo, Hong-Seog; Shim, Wan-Joo; Baek, Sang-Hong; Jeong, Jin-Ok; Ahn, Youngkeun; Kang, Woong-Chol; Kim, Young-Hak; Kim, Sang-Hyun; Hyon, Min-Su; Choi, Dong-Hoon; Nam, Chang-Wook; Park, Tae-Ho; Lee, Sang-Chol; Kim, Hyo-Soo

    2016-01-01

    The pill burden of patients with hypertension and dyslipidemia can result in poor medication compliance. This study aimed to evaluate the efficacy and safety of fixed-dose combination (FDC) therapy with olmesartan medoxomil (40 mg) and rosuvastatin (20 mg) in Korean patients with mild to moderate hypertension and dyslipidemia. This multicenter, randomized, double-blind, factorial-design study included patients aged ≥20 years with mild to moderate essential hypertension and dyslipidemia. Patients were randomly assigned to receive FDC therapy (40 mg olmesartan medoxomil, 20 mg rosuvastatin), 40 mg olmesartan medoxomil, 20 mg rosuvastatin, or a placebo. The percentage change from baseline in low-density lipoprotein cholesterol levels was compared between FDC therapy and olmesartan medoxomil, and the change from baseline in diastolic blood pressure was compared between FDC therapy and rosuvastatin 8 weeks after treatment. A total of 162 patients were included. The least square mean percentage change (standard error) from baseline in low-density lipoprotein cholesterol levels 8 weeks after treatment was significantly greater in the FDC than in the olmesartan medoxomil group (−52.3% [2.8%] vs −0.6% [3.5%], P<0.0001), and the difference was −51.7% (4.1%) (95% confidence interval: −59.8% to −43.6%). The least square mean change (standard error) from baseline in diastolic blood pressure 8 weeks after treatment was significantly greater in the FDC group than in the rosuvastatin group (−10.4 [1.2] mmHg vs 0.1 [1.6] mmHg, P<0.0001), and the difference was −10.5 (1.8) mmHg (95% confidence interval: −14.1 to −6.9 mmHg). There were 50 adverse events in 41 patients (22.7%) and eight adverse drug reactions in five patients (2.8%). The study found that FDC therapy with olmesartan medoxomil and rosuvastatin is an effective, safe treatment for patients with hypertension and dyslipidemia. This combination may improve medication compliance in patients with a large

  19. Follow up of some anthropometric and ergometric parameters during 8 week resistance training

    Directory of Open Access Journals (Sweden)

    Drapšin Miodrag

    2009-01-01

    Full Text Available Muscle cell adaptation to physical activity is well known. Hypertrophy is one of the basic changes but metabolic changes are following the anatomic ones as well. The aim of the study was to follow up the changes of the ergometric parameters and surface area of the thigh muscles evoked by the heavy resistance strength training. The study included 15 male subjects, who took part in the heavy resistance strength training lasting 8 weeks. Anthropometric (surface area of the thigh muscles and ergometric (peak power parameters were measured at the beginning and at the end of the 8 week period in order to evaluate the changes in the thigh muscles. The surface area of the thigh muscles increased significantly (p<0.05 (the left leg 9.26±0.32 cm2 and the right leg 9.07±0.57 cm2. Metabolic changes were assessed via Wingate test and also showed significant increase (p<0.05. This finding indirectly indicates the increase in anaerobic capacity of the trained muscles. The heavy resistance training evidently influenced the changes in the trained muscles. After the 8 week period both antropometric and metabolic changes were evident, and significant.

  20. The Effect of 8 Week Plates Exercise on Body Composition in Obese Women

    OpenAIRE

    Çakmakçi, O.

    2011-01-01

    The objective of this study was to explore the effects of 8-weeks modern pilates mat and ball exercise program on body mass, waist circumference and waist to hip ratio on sedentary obese women total of 58 health sedentary obese women volunteered to participate in this study. They were divided randomly into 1 of 2 groups: pilates training group (PTG; N=34) and control group (CG; N=27). A pilates training program was applied to the subjects one hour per day four days per week during...

  1. Interaction Effect of 8-Week Aerobic Exercise and Omega-3 Fatty Acid

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    Gholamreza Khedri

    2013-03-01

    Full Text Available Background: Scientific evidence indicates the impact of aerobic exercise and omega-3 fatty acids - both –are for the improvement of the cardiovascular system .The purpose of this research was about studies interaction effect of 8 weeks aerobic exercise and omega- 3 fatty acids supplementation on plasma adiponectin concentration of elderly men.Materials and Methods: In this study, 36 male non-athletes aged were between 50 to 70 year age range of men aged the city of Genaveh. Statistical sample of 36 male non- athletes in the age range 50 to 70 years old randomly selected in four groups of nine persons, respectively, the first group: exercise supplemental omega-3, Group II: Exercise placebo group: supplementation with omega-3 groups quarter: placebo. Endurance exercise training program includes 24 sessions and 3 sessions per week, with duration and intensity was determined. (55-70% HRmax. Daily supplements of omega-3 fatty acids were 2 Capsule. Blood samples were taken after fasting 14 hours before the study and 48 hours after the last training session was conducted. The data Kolmogrov-Smirnov, t-test, One-Way Anova at significance level of p≤ 0.05 were analyzed in SPSS 17. Results: The results of research after 8 weeks showed that moderate-intensity aerobic exercise and omega-3 fatty acids supplementation, only increased in the exercise + omega-3 fatty acids group (7.8% that could not created a significant increase in plasma adiponectin concentration groups. Also in final of research did not show a significant difference between groups in compare after 8 weeks. Conclusion: The results showed that by aerobic exercise and use of omega-3 fatty acids and increase amounts of adiponectin and its anti boil property, perhaps maybe that, adiponectin by effect of its preservation has a great role in prevention and reduce of cardiovascular diseases.

  2. Efficacy and safety of fixed-dose combination therapy with olmesartan medoxomil and rosuvastatin in Korean patients with mild to moderate hypertension and dyslipidemia: an 8-week, multicenter, randomized, double-blind, factorial-design study (OLSTA-D RCT: OLmesartan rosuvaSTAtin from Daewoong

    Directory of Open Access Journals (Sweden)

    Park JS

    2016-08-01

    -blind, factorial-design study included patients aged ≥20 years with mild to moderate essential hypertension and dyslipidemia. Patients were randomly assigned to receive FDC therapy (40 mg olmesartan medoxomil, 20 mg rosuvastatin, 40 mg olmesartan medoxomil, 20 mg rosuvastatin, or a placebo. The percentage change from baseline in low-density lipoprotein cholesterol levels was compared between FDC therapy and olmesartan medoxomil, and the change from baseline in diastolic blood pressure was compared between FDC therapy and rosuvastatin 8 weeks after treatment. A total of 162 patients were included. The least square mean percentage change (standard error from baseline in low-density lipoprotein cholesterol levels 8 weeks after treatment was significantly greater in the FDC than in the olmesartan medoxomil group (–52.3% [2.8%] vs –0.6% [3.5%], P<0.0001, and the difference was –51.7% (4.1% (95% confidence interval: –59.8% to –43.6%. The least square mean change (standard error from baseline in diastolic blood pressure 8 weeks after treatment was significantly greater in the FDC group than in the rosuvastatin group (–10.4 [1.2] mmHg vs 0.1 [1.6] mmHg, P<0.0001, and the difference was –10.5 (1.8 mmHg (95% confidence interval: –14.1 to –6.9 mmHg. There were 50 adverse events in 41 patients (22.7% and eight adverse drug reactions in five patients (2.8%. The study found that FDC therapy with olmesartan medoxomil and rosuvastatin is an effective, safe treatment for patients with hypertension and dyslipidemia. This combination may improve medication compliance in patients with a large pill burden. Keywords: fixed-dose combination therapy, olmesartan medoxomil, rosuvastatin, hypertension, dyslipidemia

  3. Psychopharmacotherapy of panic disorder: 8-week randomized trial with clonazepam and paroxetine

    OpenAIRE

    Nardi, A.E.; A.M. Valença; R.C. Freire; M.D. Mochcovitch; Amrein, R.; Sardinha, A.; M.N. Levitan; I. Nascimento; V.L. de-Melo-Neto; King, A. L.; A.C. de O. e Silva; A.B. Veras; G.P. Dias; G.L. Soares-Filho; R.T. da Costa

    2011-01-01

    The objective of the present randomized, open-label, naturalistic 8-week study was to compare the efficacy and safety of treatment with clonazepam (N = 63) and paroxetine (N = 57) in patients with panic disorder with or without agoraphobia. Efficacy assessment included number of panic attacks and clinician ratings of the global severity of panic disorders with the clinical global impression (CGI) improvement (CGI-I) and CGI severity (CGI-S) scales. Most patients were females (69.8 and 68.4% i...

  4. Prevalence of urinary tract infection in 2-8-week-old infants with jaundice

    Directory of Open Access Journals (Sweden)

    Partini P. Trihono

    2012-09-01

    Full Text Available Background Urinary tract infections (UTI in infants may manifest in various ways and often appear without symptoms. Previous studies have reported that jaundice has been observed in infants aged less than reported that jaundice has been observed in study in the prevalence of UTI in infants with jaundice aged 2-8 weeks is warranted in order to improve diagnosing capability and provide prompt treatment. Objective To investigate the prevalence and profiles of UTI in infants with jaundice aged 2-8 weeks. Methods This cross-sectional study was carried out in June-December 2011 in infants with jaundice aged 2-8 weeks, Subjects were patients from the Epartment of Child Health, Cipto Mangunkusumo Hospital (CMS, as well as the Pediatric Polyclinics of Budi Kemuliaan and Thamrin Hospitals. All subjects underwent total, direct and indirect bilirubin examinations, urinalyses and urine cultures. Results Of the 110 subjects recruited, the prevalence of UTI was 18.2%. More boys than girl had UTIs (13 boys, 7 girls. The microorganism found in subjects with UTIs were Escherichia coli (10/20Klebsiella pneumoniae (8/20, and Enterobacter aerogenes (2/20. Indirect hyperbilirubenia was found in 5/20 subjects. There were more subjects with UTIs in the non-exclusively breastfed (8/20 and non-breastfed (8/20 groups than in the exclusively breastfed group (4/20, the full term gestational age (GA group (17/20 than the preterm GA group (3/20, and the normal birth weight group (15/20 than the low birth weight group (5/20. The median age of jaundice onset was 3.5 days (range 1-40 days, and the median duration of jaundice was 13.5 days (range 3-56 days. Conclusion The prevalence of UTI in infants aged 2-8 weeks with jaundice was 18.2%. More boys than girls had UTIs. The most common infecting microorganism found in our subjects was Escherichia coli. In daily medical practice, infants with prolonged jaundice of more than 2 weeks should be tested by urinalysis and urine cultures

  5. Initial weight loss on an 800-kcal diet as a predictor of weight loss success after 8 weeks

    DEFF Research Database (Denmark)

    Handjieva-Darlenska, T.; Handjiev, S.; Larsen, Thomas Meinert;

    2010-01-01

    The purpose of this study was to investigate whether pre-treatment subject characteristics and weight change during the first weeks of a low-calorie diet (LCD) can predict weight loss outcomes at the end of a controlled 8-week weight loss period in overweight and obese adults.......The purpose of this study was to investigate whether pre-treatment subject characteristics and weight change during the first weeks of a low-calorie diet (LCD) can predict weight loss outcomes at the end of a controlled 8-week weight loss period in overweight and obese adults....

  6. Effects of 8 weeks of mat-based Pilates exercise on gait in chronic stroke patients

    Science.gov (United States)

    Roh, SuYeon; Gil, Ho Jong; Yoon, Sukhoon

    2016-01-01

    [Purpose] The purpose of this study was to investigate the effects of an 8-week program of Pilates exercise on gait in chronic hemiplegia patients and to determine whether or not it can be used for rehabilitation in postsrtoke patients. [Subjects and Methods] Twenty individuals with unilateral chronic hemiparetic stroke (age, 66.1 ± 4.4 yrs; height, 162.3 ± 8.3 cm; weight, 67.4 ± 12.3 kg) participated in this study and were randomly allocated equally to either a Pilates exercise group or a control group. To identify the effects of Pilates exercise, a 3-D motion analysis with 8 infrared cameras was performed. [Results] For the gait parameters, improvements were found in the Pilates exercise group for all variables, and statistical significance was observed for stride length, gait velocity, knee range of motion and hip range of motion. For the asymmetry indexes, insignificant improvements were found for all variables in the Pilates exercise group. [Conclusion] In conclusion, an 8-week program of Pilates exercise had a positive influence on improving the gait ability of poststroke patients, and the intervention could be applied to poststroke patients with various levels of physical disability by adjusting the intensity of training. PMID:27799706

  7. The UK Prospective Diabetes Study

    DEFF Research Database (Denmark)

    Olivarius, Niels de Fine; Andreasen, A.H.

    1998-01-01

    Læserbrev, som kritiserer det store UK Prospective Diabetes Study's forfattere for at overfortolke deres fund, idet marginalt signifikante p-værdier tages som udtryk for slående effekt (af at sænke blodsukkeret). Det sker selvom der f.eks. indgår effektvariabler, som kunne påvirkes af patienternes...

  8. An 8-week reactive balance training program in older healthy adults:A preliminary investigation

    Institute of Scientific and Technical Information of China (English)

    Max R. Paquette; Yuhua Li; Joseph Hoekstra; Joshua Bravo

    2015-01-01

    Background:This preliminary study examined the effects of an 8-week supervised reactive balance training program on reaction time (RT) and foot speed, static balance and balance confidence in healthy older adults compared to an exercise control group. Methods:Twenty-five older adults were randomly assigned to a reactive balance training group (QuickBoard;n=12;71.0 ± 8.6 years) or a stationary cycling group (control; n = 13; 70.2 ± 6.0 years). Both groups were tested for foot RT foot speed, static balance, and balance confidence at baseline, 4-week, 8-week, and 4-week follow-up. Results: Results indicated significant improvements in QuickBoard foot RT and speed in both groups with greater improvements in the QuickBoard group. However, no group difference was found in static balance performance. Conclusion: Although the improvements in RT and foot speed may be beneficial for fall and trip prevention, the implications of the current findings for trip avoidance and performance of daily tasks are unclear.

  9. A Prospective Study

    Directory of Open Access Journals (Sweden)

    Nandeesh BN

    2014-08-01

    Lattice and Avellino's dystrophies among dystrophies and Salzmann's nodular degeneration showed specific stromal deposits making them easily diagnosable at histopathology, whereas the rest showed non-specific stromal changes mandating correlation with clinical findings. Seven regraft corneas showed stromal fibrosis making identification of primary dystrophy impossible. However, transmural vascularization and lymphocytic stromal infiltrate were prominently noted in failed grafts though their numbers were few. Conclusion: This histopathologic study characterizes classic features of macular, Avellino's, lattice corneal dystrophies and Salzmann's degeneration for their microscopic diagnosis, while the rest showed non-specific changes. Stromal edema was prominently noted in degenerations than in dystrophies. Degree of stromal vascularization and type of cellular infiltrate need attention in regrafts. [J Interdiscipl Histopathol 2014; 2(4.000: 197-204

  10. The activity of satellite cells and myonuclei following 8 weeks of strength training in young men with suppressed testosterone levels

    DEFF Research Database (Denmark)

    Kvorning, T; Kadi, F; Schjerling, P.;

    2015-01-01

    study. The participants were randomized to treatment with a GnRH analogue, goserelin (n = 12), which suppresses testosterone or placebo (n = 10) for 12 weeks. The strength training period of 8 weeks started after 4 weeks of treatment and included exercises for all major muscles. Biopsies were obtained...

  11. Prospective study on the determinants of repeat attendance and attendance patterns in breast cancer screening using the Theory of Planned Behaviour

    NARCIS (Netherlands)

    Drossaert, C.H.C.; Boer, H.; Seydel, E.R.

    2003-01-01

    This prospective study, using the Theory of Planned Behaviour (TPB) as a theoretical framework, was carried out to identify the determinants of repeat attendance and attendance patterns in organised breast screening. A group of 2657 women filled out a baseline questionnaire, approximately 8 weeks af

  12. Effects of 8-week Pilates exercise program on menopausal symptoms and lumbar strength and flexibility in postmenopausal women.

    Science.gov (United States)

    Lee, Haelim; Caguicla, Joy Matthew Cuasay; Park, Sangseo; Kwak, Dong Jick; Won, Deuk-Yeon; Park, Yunjin; Kim, Jeeyoun; Kim, Myungki

    2016-06-01

    The aim of this study was to investigate the effects of an 8-week Pilates exercise program on menopausal symptoms and lumbar strength and flexibility in postmenopausal women. In total, 74 postmenopausal women were recruited and randomly allocated to a Pilates exercise group (n=45) and a control group (n=29). Menopausal symptoms were measured through a questionnaire, while lumbar strength was measured through a lumbar extension machine, and lumbar flexibility was measured through sit-and-reach and trunk lift tests performed before and after the Pilates exercise program, respectively. The Pilates exercises consisted of 7-10 min for warm-up, 35-40 min for the main program modified from Pilates Academy International, and 5-7 min for the cool-down, and were performed 3 times a week for 8 weeks. The results showed a significant decrease in menopausal symptoms except urogenital symptoms. Also, the results presented a significant increase in lumbar strength and flexibility after 8 weeks of the Pilates exercise program. We concluded that an 8-week Pilates exercise program is effective in decreasing menopausal symptoms and increasing lumbar strength and flexibility. PMID:27419122

  13. Beneficial Effects of an 8-Week, Very Low Carbohydrate Diet Intervention on Obese Subjects

    Directory of Open Access Journals (Sweden)

    Yunjuan Gu

    2013-01-01

    Full Text Available Aim. To investigate the effects of weight loss during an 8-week very low carbohydrate diet (VLCD on improvement of metabolic parameters, adipose distribution and body composition, and insulin resistance and sensitivity in Chinese obese subjects. Methods. Fifty-three healthy obese volunteers were given an 8-week VLCD. The outcomes were changes in anthropometry, body composition, metabolic profile, abdominal fat distribution, liver fat percent (LFP, and insulin resistance and sensitivity. Results. A total of 46 (86.8% obese subjects completed the study. The VLCD caused a weight loss of −8.7±0.6 kg (mean ± standard error (SE, P<0.0001 combined with a significant improvement of metabolic profile. In both male and female, nonesterified fatty acid (NEFA significantly decreased (−166.2±47.6 μmol/L, P=0.001 and β-hydroxybutyric acid (BHA increased (0.15±0.06 mmol/L, P=0.004 after eight weeks of VLCD intervention. The significant reductions in subcutaneous fat area (SFA, visceral fat area (VFA, and LFP were −66.5±7.9 cm2, −35.3±3.9 cm2, and −16.4±2.4%, respectively (all P values P<0.0001. HOMA IR and HOMA β significantly decreased while whole body insulin sensitivity index (WBISI increased (all P values P<0.001. Conclusion. Eight weeks of VLCD was an effective intervention in obese subjects. These beneficial effects may be associated with enhanced hepatic and whole-body lipolysis and oxidation.

  14. The Effects of 8-Weeks Aerobic Exercise Program on Blood Lipids and Cholesterol Profile of Smokers vs. Non Smokers

    Science.gov (United States)

    Taifour, Akef; AL-Shishani, Ahmad; Khasawneh, Aman; AL-Nawaiseh, Ali; Bakeer, Mohammed

    2015-01-01

    The aim of this study was to compare the effects of 8-week aerobic exercise program on blood lipids and cholesterol profile of smoker's vs. non-smokers. A total of 34 male subjects (18 non-smokers and 16 smokers) took part in this study. Both groups were pre- and post tested in their blood-lipids and cholesterol profile before and after the 8-week…

  15. Effects of 8 Weeks of Aerobic Exercise on Matrix Metalloproteinase-9 and Tissue Inhibitor Levels in Type II Diabetic Women

    OpenAIRE

    Mostafa Dastani; Amir Rashidlamir; Akram Alizadeh; Mehdi Seyedolhosseini; Ahmad Ebrahimi-AtriP

    2014-01-01

    Background: Increased vascular stiffness is a marker of atherosclerosis, which is diagnosed in the early stages of diabetes II. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are a family of proteolytic enzymes necessary for structure and function of great vessels. This study examined the effects of 8 weeks of aerobic exercise on MMPR9R and TIMP-1 levels in type II diabetic women. Materials and Methods: This is a quasi-experimental study which included 20 in type II d...

  16. Adjunctive Aripiprazole Treatment for Risperidone-Induced Hyperprolactinemia: An 8-Week Randomized, Open-Label, Comparative Clinical Trial

    OpenAIRE

    Jingyuan Zhao; Xueqin Song; Xiaoqing Ai; Xiaojing Gu; Guangbiao Huang; Xue Li; Lijuan Pang; Minli Ding; Shuang Ding; Luxian Lv

    2015-01-01

    Objective The present study aimed to evaluate the efficacy and safety of adjunctive aripiprazole treatment in schizophrenia patients with risperidone-induced hyperprolactinemia. Methods One hundred and thirteen patients who were receiving a stable dose of risperidone were randomly assigned to either adjunctive aripiprazole treatment (10 mg/day) (aripiprazole group) or no additional treatment (control group) at a 1:1 ratio for 8 weeks. Schizophrenia symptoms were measured using the Positive an...

  17. The effects of an 8-week stabilization exercise program on lumbar movement sense in patients with low back pain

    OpenAIRE

    Boucher, Jean-Alexandre; Preuss, Richard; Henry, Sharon M.; Dumas, Jean-Pierre; Larivière, Christian

    2016-01-01

    Background Lumbar stabilization exercises have gained popularity and credibility in patients with non-acute low back pain. Previous research provides more support to strength/resistance and coordination/stabilisation programs. Some authors also suggest adding strength/resistance training following motor control exercises. However, the effect of such a lumbar stabilization program on lumbar proprioception has never been tested so far. The present study investigated the effects of an 8-week sta...

  18. THE EPPECT OF 8- WEEK AEROBIC EXERCISE ON BLOOD GLUCOSE AND BODY MASS IN FEMALE DIABETES II PATIENTS

    OpenAIRE

    Seyed Mohammad Marandi; Fahimeh Esfarjani; Fatemeh Rashidi

    2011-01-01

    This study aims at finding the effect of 8-week aerobic exercise on blood glucose and bodymass in female diabetes II patients. Thirty Five women with type II diabetes were purposefullyselected and divided to a control group (n=17) and an exercise group (n=18). The trainingprogram which continued three times a week for eight weeks included 60-minute aerobicexercises with the intensity of 65 to 70 percent of maximal heart rate. The results of the dataanalysis indicated that there is significant...

  19. 8周常规康复训练和本体感觉加强训练对半月板术后患者膝关节本体感觉和肌力影响的比较%Comparative Study on Effects of 8-week Conventional Rehabilitation and Proprioception Strengthen Training on Knee Joint Proprioception and Strength of Patients with Meniscectomy

    Institute of Scientific and Technical Information of China (English)

    李玉周; 胡英琪; 李国平

    2012-01-01

    目的:探讨8周常规康复训练和本体感觉加强训练对膝关节半月板术后患者膝关节本体感觉和肌力的影响,以指导临床康复训练.方法:25名半月板术后患者,依照均衡原则分为常规康复训练组(13人,以肌力和关节活动度训练为主)和本体感觉加强训练组(12人,以本体感觉训练为主).在8周训练的不同时间点,使用BIODEX PRO 3 SYS测定膝关节主动30°位置觉(术前和术后4、8周)及屈膝30°和60°股四头肌最大等长肌力(术前和术后8周),于术前和术后2、4、8周使用X-SENS测定三维位置觉.结果:8周不同康复训练后,两组患侧、健侧主动30°位置觉较术前均有加强,患侧变化有统计学意义(P=0.022),不同康复处方训练对患侧、健侧主动30°位置觉的影响无差异.8周不同处方训练后两组三维位置觉在4周和8周均有明显改善,不同处方训练对患侧、健侧三维位置觉的影响无差异.8周不同处方训练后两组患侧、健侧30°和60°等长肌力均呈增长趋势,不同处方训练对患侧、健侧30°和60°等长肌力的影响无显著性差异.结论:8周常规康复训练和本体感觉加强训练均能增强膝关节半月板术后患者主动30°位置觉和三维位置觉,但两种训练对本体感觉的影响无显著性差别,可能与其均增强了肌力有关.%Objective To compare the influences of 8 -week conventional rehabilitation and proprioception strengthen training on the knee joint proprioception and strength of patients with meniscectomy. Methods Twenty five patients with meniscectomy were randomly divided into two groups: conventional rehabilitation group (rc=13, mainly underwent muscle strength and motion of joint training) and proprioception strengthen training group (re =12,mainly underwent proprioception training). The active joint sense of position at 30° before,and 4 and 8 weeks after training,isometric strength of quadriceps femoris at 30° and 60

  20. The Efficacy of Neurofeedback in Patients with Major Depressive Disorder: An Open Labeled Prospective Study.

    Science.gov (United States)

    Cheon, Eun-Jin; Koo, Bon-Hoon; Choi, Joong-Hyun

    2016-03-01

    The purpose of this study was to evaluate the effect of neurofeedback on depressive symptoms and electrophysiological disturbances in patients with major depressive disorder. We recruited participants suffering from depression to evaluate efficacy of left prefrontal beta with alpha/theta training. An 8-week, prospective, open-label study was undertaken. Twenty participants were recruited. The treatment protocol was twice or three times a week training of beta at F3 with alpha/theta at Pz for 8 weeks. When every visit, patients were received beta training for 30 min, and then alpha/theta training for 30 min. Baseline, 4 and 8 week scores of; the Hamilton rating scale for Depression (HAM-D), the Hamilton rating scale for Anxiety (HAM-A), the Beck Depression Inventory (BDI)-II, the Beck Anxiety Inventory (BAI), Clinical global impression-severity (CGI-S), and pre- and post-treatment resting state EEGs were compared. Interhemispheric alpha power asymmetry (A score) was computed for homologous sites F3-F4. Pre- and post-training clinical assessments revealed significant improvements in HAM-D, HAM-A, BDI, and CGI-S scores. Cumulative response rates by HAM-D were 35.0 and 75.0 % at 4 and 8 weeks, respectively, corresponding cumulative remission rates by HAM-D were 15.0 and 55.0 %, respectively. No significant differences were found between pre- and post-treatment A score. Neurofeedback treatment could improve depressive symptoms significantly. In addition, anxiety symptoms and clinical illness severity decreased significantly after neurofeedback treatment. Despite its several limitations, such as, small sample size and lack of a control group, this study suggested neurofeedback has significant effects in patients with major depressive disorder. PMID:26392114

  1. The Effect of 8 weeks aerobic exercise and yoga on primary dismenorrhea

    Directory of Open Access Journals (Sweden)

    T Siahpour

    2013-10-01

    Full Text Available Abstract Background & aim: Dysmenorrhea, menstrual cramps without physical pain is a common complaint in gynecology. The aim of this study was to investigate the effect of aerobic training on primary Dysmenorrhea in a period of 8 weeks. Materials & Methods: In the present clinical-trial study, 60 non-athlete girls with primary Dysmenorrhea were randomly divided into three groups: aerobic training, yoga and control groups. Based on the visual analog scale of pain intensity, pain duration and amount of analgesics administered was assessed before and after the period of primary Dysmenorrhea using a questionnaire. In this eight-week exercise program, the aerobic exercises group for 60 minutes in three weeks and yoga exercises group in three sessions per week for 60 minutes, the yoga breathing techniques, exercises, asana and relaxation techniques were performed. There was no intervention in the control group. Data were analyzed by Wilcoxon, Kruskal-Wallis and Mann Whitney (p0.05. There was a significant decrease in the analgesic consumption in the yoga group compared to the exercise group (p<0/05. Conclusion: Both aerobic and yoga are effective in the treatment of primary Dysmenorrhea, but yoga has a greater reduction property on drug dosage. Key words: primary dysmenorrhea, aerobic exercise, yoga exercise, female student

  2. Psychopharmacotherapy of panic disorder: 8-week randomized trial with clonazepam and paroxetine

    Directory of Open Access Journals (Sweden)

    A.E. Nardi

    2011-04-01

    Full Text Available The objective of the present randomized, open-label, naturalistic 8-week study was to compare the efficacy and safety of treatment with clonazepam (N = 63 and paroxetine (N = 57 in patients with panic disorder with or without agoraphobia. Efficacy assessment included number of panic attacks and clinician ratings of the global severity of panic disorders with the clinical global impression (CGI improvement (CGI-I and CGI severity (CGI-S scales. Most patients were females (69.8 and 68.4% in the clonazepam and paroxetine groups, respectively and age (mean ± SD was 35.9 ± 9.6 years for the clonazepam group and 33.7 ± 8.8 years for the paroxetine group. Treatment with clonazepam versus paroxetine resulted in fewer weekly panic attacks at week 4 (0.1 vs 0.5, respectively; P < 0.01, and greater clinical improvements at week 8 (CGI-I: 1.6 vs 2.9; P = 0.04. Anxiety severity was significantly reduced with clonazepam versus paroxetine at weeks 1 and 2, with no difference in panic disorder severity. Patients treated with clonazepam had fewer adverse events than patients treated with paroxetine (73 vs 95%; P = 0.001. The most common adverse events were drowsiness/fatigue (57%, memory/concentration difficulties (24%, and sexual dysfunction (11% in the clonazepam group and drowsiness/fatigue (81%, sexual dysfunction (70%, and nausea/vomiting (61% in the paroxetine group. This naturalistic study confirms the efficacy and tolerability of clonazepam and paroxetine in the acute treatment of patients with panic disorder.

  3. Neurocutaneous syndrome: A prospective study

    Directory of Open Access Journals (Sweden)

    Radheshyam Purkait

    2011-01-01

    Full Text Available Background: Neurocutaneous syndromes (NCS are a group of genetic disorders that produce a variety of developmental abnormalities of the skin along with an increased risk of neurological complications. Cutaneous manifestations usually appear early in life and progress with time, but neurological features generally present at a later age. There is a paucity of data regarding the evolution of skin lesions and their correlation with the central nervous system involvement in children. Aim: The primary objective was to track the course of skin lesions in various forms of NCS in the pediatric age group. Our secondary aim was to assess whether there was any predictive value of the lesions in relation to the neurological manifestations. Materials and Methods: This prospective longitudinal study was conducted at a tertiary care pediatric dermatology referral clinic of the Institute of Child Health, Kolkata, West Bengal. Children between the age group 0 and 12 years were included in the study on the basis of standard diagnostic criteria for different NCS, during the period from March, 2000 to February, 2004, and each of the enrolled cases were followed up for a duration of six years. Results: The study population comprised of 67 children (35 boys, 32 girls.The mean age of presentation was 33.8±27.8 months (range 10 days to 111 months. The various forms of NCS observed was neurofibromatosis 1(NF1 (n=33, tuberous sclerosis complex (TSC (n=23, Sturge Weber syndrome (n=6, ataxia telangiectasia (n=2, PHACE syndrome (n=1, incontinentia pigmenti (n=1, and hypomelanosis of Ito (n=1. The presentations were varied, ranging from predominantly cutaneous to primarily neurological, depending on the disease entity and age group concerned. There was a significant increase in the number of café au lait macules (CALMs with time (P=0.0002 in NF1, unlike that of hypopigmented macules of TSC (P=0.15. Statistically, no relation was documented between the evolution of skin

  4. An 8-week interdisciplinary learning module, which focuses on innovation and entrepreneurship

    DEFF Research Database (Denmark)

    Sørensen, Brigitte; Andersen, Helle Tvorup; Duus, Lene;

    2015-01-01

    through virtual discussions, e-learning and more. A central part of the evaluating test of the module is an innovative camp. During 24 hours the 250 students are guided through an innovative process to form a concept about the health system of the future. Aim The workshop's aim is activity participation......Background In Denmark all the Professional bachelor degree educations have a common interdisciplinary module. UCN has five different bachelors degree in health. The five kinds of student spent 8 weeks together, learning about interdisciplinary and health. The learning modules are coordinated...... by a team with members from the five educations. The team has developed an 8 -week learning mod-ule, which focuses on innovation and entrepreneurship. The interdisciplinary module has an inno-vative didactic design using blended learning as the overarching principle. Relevance Our workshop contributes...

  5. THE EFFECT OF 8-WEEK LOW IMPACT AEROBIC EXERCISE ON PLASMA FIBRINOGEN CONCENTRATION IN OLDER WOMEN

    OpenAIRE

    Mohammad Faramarzi; Shahla Dehghan

    2011-01-01

    The aim of this research was to investigate the effect of 8-week low impact rhythmic aerobic(LIA) exercise on plasma fibrinogen concentration in older women. subjects were 23 healthyand enable to do physical activity old women of one of retirement homes. Subjects divided totwo groups including experimental (n=14) and control (n=11) and after 8 hours nightly fastingfor assessment fibrinogen 5cc blood sampling was derived from anterior vein. Afterwardexperimental groups were participated in LIA...

  6. Ruptured cornual ectopic pregnancy at 8 weeks gestation- successful conservative approach: a case report

    OpenAIRE

    Shobha S. Shiragur; Vijayalaxmi Gobbur R; Manpreetkaur Tehalia J; Rathi Doshi; Sreedevi Kori

    2013-01-01

    Cornual pregnancy is a rare form of ectopic pregnancy that usually leads to uterine rupture with resultant life threatening hemorrhage. The mortality of interstitial pregnancies is more than twice that of other tubal pregnancies. Cornual pregnancies often rupture later than other tubal pregnancies because the myometrium is more distensible than the fallopian tube. We report a case where a patient presented at 8 weeks of gestational age with ruptured cornual ectopic pregnancy and hemoperitone...

  7. Effects of 8 Weeks of Aerobic Exercise on Matrix Metalloproteinase-9 and Tissue Inhibitor Levels in Type II Diabetic Women

    Directory of Open Access Journals (Sweden)

    Mostafa Dastani

    2014-06-01

    Full Text Available Background: Increased vascular stiffness is a marker of atherosclerosis, which is diagnosed in the early stages of diabetes II. Matrix metalloproteinases (MMPs and their tissue inhibitors (TIMPs are a family of proteolytic enzymes necessary for structure and function of great vessels. This study examined the effects of 8 weeks of aerobic exercise on MMPR9R and TIMP-1 levels in type II diabetic women. Materials and Methods: This is a quasi-experimental study which included 20 in type II diabetic women with mean age of 53.2±2.5 years, body mass index (BMI of 28.73±2.27 and fat percentage of 30.6±2.05, who were randomly divided into two groups: aerobic exercise group (8 weeks, 3 sessions per week for 50 minutes and control group. To examine changes in MMPR9R and TIMP-1, 5 ml of blood was taken from the brachial vein of patients before and 48 hours after completion of exercise period and after 12 hours of fasting at rest. Data analysis was performed using SPSS-16 software with the independent and paired t-tests. Results: A significant decrease was observed in body mass index and body fat percentage in the experimental group (p<0.05. Compared with the control group, the aerobic exercise group showed a significant decrease in MMPR9R (p=0.01 and a significant increase in TIMP-1 levels (p=0.02 after 8 weeks of aerobic exercise. Conclusion: The results showed that aerobic exercise as a stimulus can change the levels of matrix metalloproteinases and their tissue inhibitors in order to prevent cardiovascular diseases in diabetics.

  8. Haematuria analysed--a prospective study.

    OpenAIRE

    Gillatt, D A; O'Reilly, P H

    1987-01-01

    One hundred consecutive cases of haematuria were studied prospectively. The results showed a high proportion (52%) of serious urological disease. The need for thorough investigation of even minor degrees of haematuria is again emphasized.

  9. Pain trajectory and exercise-induced pain flares during 8 weeks of neuromuscular exercise in individuals with knee and hip pain

    DEFF Research Database (Denmark)

    Sandal, L F; Roos, E M; Bøgesvang, S J;

    2016-01-01

    acute exercise-induced pain flares in persons with knee or hip pain. DESIGN: Individuals above 35 years self-reporting persistent knee or hip pain for the past 3 months were offered 8 weeks of supervised NEMEX, performed in groups twice weekly. The program consisted of 11 exercises focusing on joint......OBJECTIVE: Patients considering or engaged in exercise as treatment may expect or experience transient increases in joint pain, causing fear of exercise and influencing compliance. This study investigated the pain trajectory during an 8-week neuromuscular exercise (NEMEX) program together with...... stability and neuromuscular control. Participants self-reported joint pain on a 0-10 numerical rating scale (NRS) at baseline and 8-weeks follow-up. NRS pain ratings were also collected before and immediately after every attended exercise session. RESULTS: Joint pain was reduced from baseline (NRS 3.6; 95...

  10. Effect of sand versus grass training surfaces during an 8-week pre-season conditioning programme in team sport athletes.

    Science.gov (United States)

    Binnie, Martyn John; Dawson, Brian; Arnot, Mark Alexander; Pinnington, Hugh; Landers, Grant; Peeling, Peter

    2014-01-01

    This study compared the use of sand and grass training surfaces throughout an 8-week conditioning programme in well-trained female team sport athletes (n = 24). Performance testing was conducted pre- and post-training and included measures of leg strength and balance, vertical jump, agility, 20 m speed, repeat speed (8 × 20 m every 20 s), as well as running economy and maximal oxygen consumption (VO2max). Heart rate (HR), training load (rating of perceived exertion (RPE) × duration), movement patterns and perceptual measures were monitored throughout each training session. Participants completed 2 × 1 h conditioning sessions per week on sand (SAND) or grass (GRASS) surfaces, incorporating interval training, sprint and agility drills, and small-sided games. Results showed a significantly higher (P training load in the SAND versus GRASS group throughout each week of training, plus some moderate effect sizes to suggest lower perceptual ratings of soreness and fatigue on SAND. Significantly greater (P training surfaces throughout an 8-week conditioning programme can significantly increase the relative exercise intensity and training load, subsequently leading to superior improvements in aerobic fitness.

  11. Ziprasidone Vs Olanzapine in Recent-Onset Schizophrenia and Schizoaffective Disorder : Results of an 8-Week Double-Blind Randomized Controlled Trial

    NARCIS (Netherlands)

    Grootens, K. P.; van Veelen, N. M. J.; Peuskens, J.; Sabbe, B. G. C.; Thys, E.; Buitelaar, J. K.; Verkes, R. J.; Kahn, R. S.

    2011-01-01

    Introduction: Head-to-head comparisons of antipsychotics have predominantly included patients with chronic conditions. The aim of the present study was to compare the efficacy and tolerability of ziprasidone and olanzapine in patients with recent-onset schizophrenia. Methods: The study was an 8-week

  12. A prospective study of gentamicin ototoxicity

    DEFF Research Database (Denmark)

    Winkel, O; Hansen, M M; Kaaber-Bühler, Søren;

    2010-01-01

    Twenty patients were included in a prospective otoneurological study performed to assess the ototoxicity in gentamicin therapy. Gentamicin was administered intravenously, and the serum level was currently determined. Audiographic and electronystagmographic studies were carried out at the institut......Twenty patients were included in a prospective otoneurological study performed to assess the ototoxicity in gentamicin therapy. Gentamicin was administered intravenously, and the serum level was currently determined. Audiographic and electronystagmographic studies were carried out...... of gentamicin did not rule out the possiblity of ototoxicity. These results urge the continuing of prospective studies and indicate that gentamicin should be used only as a link in the primary treatment of severe infection or in cases in which other, less toxic agents have failed....

  13. Complications of ERCP: a prospective study

    DEFF Research Database (Denmark)

    Christensen, Merete; Matzen, Peter; Schulze, Svend;

    2004-01-01

    included in this prospective study. Complications were assessed at the time of ERCP and by postal/telephone contact at 30-days after the procedure. RESULTS: A total of 1177 ERCPs were included in the analysis, of which 56.2% were therapeutic. The 30-day complication rate was 15.9%; the procedure...... analysis. Risk of pancreatitis was increased with age under 40 years ( p = 0.0078), placement of stent ( p = 0.031), and a dilated bile duct ( p = 0.036). CONCLUSIONS: This prospective study confirms that the complication rate of ERCP including therapeutic procedures is high. Cardiopulmonary complications...

  14. Monitoring Levothyroxine Dose during Pregnancy: A Prospective Study

    Directory of Open Access Journals (Sweden)

    Juhi Agarwal

    2011-01-01

    Full Text Available Problem statement: Thyroid dysfunction in pregnant women can influence the outcome for mother and fetus at all stages of pregnancy. As the fetus is entirely dependent on maternal thyroid hormones for its development until about 13 weeks of gestation, it is important to ensure adequate thyroxine substitution in pregnant women during the first trimester. Objective: The aim of this prospective study was to explore whether hypothyroidic pregnant women are adequately levothyroxine (L-T4 substituted in early pregnancy. Approach: During March 2008 to July 2009, 93 pregnant females with thyroid diseases were followed at the outpatient department of INMAS. At the first visit 86 patients were on L-T4 substitution for hypothyroidism. Seven other patients had hyperthyroidism. The patients were regularly followed every 4-8 weeks during pregnancy for dose adjustment. Before each visit serum Free Thyroxine (FT4 and TSH concentrations were determined. Results: Of the 86 patients on thyroxine substitution for hypothyroidism 56 (65.12% had serum TSH values within the reference range at their first TSH test. Thirty (34.9% had TSH values outside the reference range. In 5 patients TSH was 4 increase at the first evaluation during pregnancy was 17.46±30.8µg day1. In the 50 patients who needed to increase L-T4, 26% reached a definitive therapeutic dosage within 12th week of pregnancy, 24% within the 20th week and 50% within the 31st week. Conclusion/Recommendations: In 34.9% of pregnant women on L-T4 substitution for hypothyroidism, serum TSH values were abnormal when first tested and they had increased chances of fetal loss if not treated timely. Thyroid function in pregnant women on thyroxine substitution should be monitored as soon as pregnancy has been confirmed and carefully followed during pregnancy.

  15. Can early breastfeeding support increase the 6-8 week breastfeeding prevalence rate?

    Science.gov (United States)

    Price, Linda

    2014-05-01

    Breastfeeding has significant health benefits for mothers and babies and is an important strategy to reduce health inequalities (UNICEF, 2010). The Baby Friendly Initiative, a strategy to increase breastfeeding rates, has been adopted by the trust. In line with the trust's priorities, the health visiting team initiated a project to increase the 6-8 breastfeeding prevalence rates. Breastfeeding mothers in a defined project area were offered breastfeeding support in their homes within the first postnatal week. Although the results after six months did demonstrate an overall increase in the 6-8 week prevalence rate of 5%, the monthly figures where disappointingly inconsistent and it was difficult to attribute the rise to the increased support offered. Nevertheless, the feedback from mothers who received support demonstrated that it was valued and had a positive impact on their confidence to continue to breastfeed. PMID:24881195

  16. Ruptured cornual ectopic pregnancy at 8 weeks gestation- successful conservative approach: a case report

    Directory of Open Access Journals (Sweden)

    Shobha S. Shiragur

    2013-08-01

    Full Text Available Cornual pregnancy is a rare form of ectopic pregnancy that usually leads to uterine rupture with resultant life threatening hemorrhage. The mortality of interstitial pregnancies is more than twice that of other tubal pregnancies. Cornual pregnancies often rupture later than other tubal pregnancies because the myometrium is more distensible than the fallopian tube. We report a case where a patient presented at 8 weeks of gestational age with ruptured cornual ectopic pregnancy and hemoperitoneum. Emergency Laparotomy was done and cornual rupture was sutured successfully. Close monitoring of pregnancies in these patients is important to prevent a deleterious delay in treatment of a cornual pregnancy. [Int J Reprod Contracept Obstet Gynecol 2013; 2(4.000: 671-673

  17. Calcipotriol versus coal tar: a prospective randomized study in stable plaque psoriasis

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, V.; Kaur, I.; Kumar, B. [Postgraduate Institute of Medicinal Education & Research, Chandigarh (India)

    2003-10-01

    Topical therapies are the first line of treatment for patients with stable plaque psoriasis (SPP) affecting a limited body surface area. Very few trials comparing newer agents, such as 0.005% topical calcipotriol, with conventional modes of therapy, such as coal tar ointment, have been reported. A prospective, right-left randomized, investigator-blinded study with a 12-week treatment period and an 8-week follow-up period was performed. It was found that 0.005% calcipotriol ointment produced a faster initial response and had better cosmetic acceptability in patients, although after a long period of treatment, i.e. 12 weeks, 5% coal tar ointment had comparable efficacy. There was no statistically significant difference in the relapse rates between the two modalities.

  18. Effectiveness of coordination exercise in improving cognitive function in older adults: a prospective study

    Directory of Open Access Journals (Sweden)

    Kwok TCY

    2011-09-01

    Full Text Available Timothy CY Kwok1,2, KC Lam2, PS Wong2, WW Chau2, Kenneth SL Yuen2,3, KT Ting2, Elite WK Chung2, Jessie CY Li2, Florence KY Ho2,41Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 2Jockey Club Centre for Positive Ageing, 3Laboratory of Neuropsychology, Department of Psychology, The University of Hong Kong, 4Jockey Club CADENZA Hub, Hong Kong SARBackground: Studies on the effect of a low intensity coordination exercise on the elderly with limited mobility are sparse. This prospective study attempted to compare the effectiveness of a customized coordination exercise and a strength exercise in improving the cognitive functioning and physical mobility on the elderly.Methods: Participants from two centers for the elderly were allocated to practice either an 8-week coordination training (CT program or an 8-week towel exercise (TE program. The Chinese Mini-Mental State Examination and Chinese Dementia Rating Scale (CDRS were used to measure cognitive functioning of participants, and Timed Up-and-Go test for physical mobility. These assessments were administered before and after the program.Results: Paired t-tests showed that the CDRS scores of the CT group improved significantly from 114.8 at pre-test to 119.3 after training (P = 0.045. The CDRS scores of the TE group also improved from 114.9 at pre-test to 116.9 after training.Conclusion: Findings from this prospective study demonstrated that low-intensity level mind-body exercise could be beneficial to the cognitive functioning of older adults.Keywords: coordination exercise, cognitive function, elderly, Chinese

  19. Immunosuppression for 6-8 weeks after modified donor lymphocyte infusion reduced acute graft-versus-host disease without influencing graft-versus-leukemia effect in haploidentical transplant

    Institute of Scientific and Technical Information of China (English)

    Yan Chenhua; Xu Lanping; Liu Daihong; Chen Huan; Wang Yu; Liu Kaiyan; Huang Xiaojun

    2014-01-01

    Background In haploidentical hematopoietic stem cell transplantation (HSCT),the duration of graft-versus-host disease (GVHD) prophylaxis after modified donor lymphocyte infusion (DLI) was the only risk factor of DLI-associated grades 3-4 acute GVHD.However,the successful application of modified DLI depended not only on the reduction of severe GVHD,but also on the preservation of graft-versus-leukemia (GVL) effect.Therefore,this study was performed to compare the impact of prophylaxis for 6-8 weeks and prophylaxis for <6 weeks on GVL effect after modified DLI in haploidentical HSCT.Methods A total of 103 consecutive patients developing hematological relapse or minimal residual disease (MRD)-positive status after haploidentical HSCT and receiving modified DLI were investigated retrospectively.Fifty-two patients received prophylaxis for 6-8 weeks after modified DLI; the remaining 51 patients received prophylaxis for <6 weeks.Results First,compared with prophylaxis for <6 weeks,prophylaxis for 6-8 weeks reduced incidence of relapse in total patients (26.6% vs.69.0%,P <0.001).Besides,prophylaxis for 6-8 weeks also reduced incidence of relapse in 54 patients developing hematological relapse post-transplant (P=0.018) and in 49 patients developing MRD-positive status post-transplant (P <0.001).Second,prophylaxis for 6-8 weeks reduced incidence of acute GVHD (P <0.05),reduced the therapeutic application of immunosuppressive agents (P=0.019),but increased the incidence of chronic GVHD (P<0.05).Third,prophylaxis for 6-8 weeks improved overall survival and disease-free survival in total patients,as well as in patients developing hematological relapse post-transplant and in patients developing MRD-positive status post-transplant (P <0.05).Conclusions In haploidentical HSCT,prophylaxis for 6-8 weeks after modified DLI does not reduce GVL effect,but reduces the incidence of DLI-associated acute GVHD compared with prophylaxis for <6 weeks.This strategy will

  20. Results of a prospective study

    OpenAIRE

    Weblus, Anna Julka

    2010-01-01

    Listening to music can influence body and mind. But whether aspects of quality of life during the beginning of a systemic cytostatic chemotherapy of women with gynecologic malignancies can be influenced by listening to Mozart or relaxation music is being investigated in this study for the first time. For this purpose 61 women with a malignant tumor of the breast, the ovaries, the cervix, the endometrium or the tubes, in need of a cytostatic chemotherapy, have been investigated during the firs...

  1. A prospective study of gentamicin ototoxicity

    DEFF Research Database (Denmark)

    Winkel, O; Hansen, M M; Kaaber-Bühler, Søren;

    1978-01-01

    Twenty patients were included in a prospective otoneurological study performed to assess the ototoxicity in gentamicin therapy. Gentamicin was administered intravenously, and the serum level was currently determined. Audiographic and electronystagmographic studies were carried out at the institut......Twenty patients were included in a prospective otoneurological study performed to assess the ototoxicity in gentamicin therapy. Gentamicin was administered intravenously, and the serum level was currently determined. Audiographic and electronystagmographic studies were carried out...... at the institution and discontinuation of the treatment and again a few weeks later. Ten patients exhibited ototoxic actions, predominantly cochlear, 4 of the cases being fully reversible. Two patients developed severe hearing loss, associated in one with bilateral extinction of vestibular function. Low serum levels...

  2. Separating the mink dam from the litter at 7 or 8 weeks after delivery

    DEFF Research Database (Denmark)

    Malmkvist, Jens; Palme, Rupert; Larsen, Torben;

    2015-01-01

    The optimal timing of separating the mink dam from the litter is suggested to be a balance between the partly conflicting needs of the mother and the kits. Early removal of the dam or partial removal of the litter may protect the dam against exhaustion. Little is known about the maternal motivation...... around the time of separation. Therefore, we investigated the effects of separating the dam from the litter, using brown first-parity dams (N=374) randomly assigned within each date of delivery to two treatment groups: The dam was taken away from the litter either at day 49 ±1 (7w, N=185) or at day 56 ±1...... (8w, N=189) after birth. The aim was to investigate whether the dams had a different motivation to take care of the litter after 7 and 8 weeks, estimated by non-invasive determination of cortisol (FCM: Faecal Corticsol Metabolites) and dam calls the first week after separation. The two treatment...

  3. Medial orbital gyrus modulation during spatial perspective changes: Pre- vs. post-8 weeks mindfulness meditation.

    Science.gov (United States)

    Tomasino, Barbara; Campanella, Fabio; Fabbro, Franco

    2016-02-01

    Mindfulness meditation exercises the ability to shift to an "observer perspective". That means learning to observe internally and externally arising stimulations in a detached perspective. Both before and after attending a 8-weeks mindfulness training (MT) participants underwent an fMRI experiment (serving as their own internal control) and solved a own-body mental transformation task, which is used to investigate embodiment and perspective taking (and an non-bodily mental transformation task as control). We found a stimulus×time-points interaction: the own-body mental transformation task (vs. non-bodily) in the post (vs. pre-MT) significantly increased activations in the medial orbital gyrus. The signal change in the right medial orbital gyrus significantly correlated with changes in a self-maturity personality scale. A brief MT caused increased activation in areas involved in self related processing and person perspective changes, together with an increase in self-maturity, consistently with the aim of mindfulness meditation that is exercising change in self perspective. PMID:26821244

  4. Oral treatment of pressure ulcers with polaprezinc (zinc L-carnosine complex): 8-week open-label trial.

    Science.gov (United States)

    Sakae, Kensaku; Yanagisawa, Hiroyuki

    2014-06-01

    Polaprezinc (zinc L-carnosine complex) is a tablet commonly prescribed for gastric ulcers in Japan. Recently, we reported the effects of polaprezinc on pressure ulcer healing at 4-week follow-up. We aimed to further evaluate the efficacy and safety of polaprezinc in 8-week treatment for chronic pressure ulcers. Patients with stage II-IV pressure ulcers for ≥ 8 weeks received 150 mg/day polaprezinc (containing 116 mg L-carnosine and 34 mg zinc) per os for a maximum of 8 weeks. We measured the severity of pressure ulcers weekly using the Pressure Ulcer Scale for Healing (PUSH) score and monitored blood biochemistry. Fourteen patients (nine men; 68.4 ± 11.8 years) were enrolled. Pressure ulcer stages were II (one patient; 7 %), III (nine; 64 %), and IV (four; 29 %). The PUSH score improved significantly from 8.1 [95 % CI, 6.0-10.3] at baseline to -1.4 [-4.0 to 1.1] after 8 weeks (P zinc levels increased significantly (P zinc ratios (P < 0.001) decreased significantly. In one patient, preexisting copper deficiency deteriorated. These preliminary data suggest that polaprezinc may be effective and well-tolerated in 8-week treatment of pressure ulcers and could be a candidate for their oral treatment. PMID:24691900

  5. Effect of 8 weeks of pre-season training on body composition, physical fitness, anaerobic capacity, and isokinetic muscle strength in male and female collegiate taekwondo athletes.

    Science.gov (United States)

    Seo, Myong-Won; Jung, Hyun-Chul; Song, Jong-Kook; Kim, Hyun-Bae

    2015-04-01

    The purpose of the study was to determine the effect of 8 weeks pre-season training on body composition, physical fitness, anaerobic capacity, and isokinetic strength in collegiate taekwondo athletes. Thirty-four collegiate athletes (male: 22, female: 12) participated. Body composition, bone mineral density, physical fitness, anaerobic capacity, and isokinetic muscle strength were tested. After statistical analysis was performed the results indicated that there were significant decreases in body weight, percent body fat, and fat tissue after 8 weeks of pre-season training. Bone mineral density increased significantly only in males. There were significant improvements in the 50 m shuttle run and 20 m multistage endurance run in both males and females. The sit & reach test and standing long jump were not significantly changed after 8 weeks. Relative peak power and anaerobic capacity were significantly improved in males. Significant increases in angular velocity were observed for knee extension at both % BW 60°/sec and 180°/sec in both males and females. A significant increase in angular velocity was seen for right knee flexion at % BW 60°/sec for males, but it decreased at % BW 180°/sec for both males and females. In conclusion, this study suggests that 8 weeks of pre-season training has a positive effect on body composition, physical fitness, anaerobic capacity, isokinetic muscular strength, and endurance. Nevertheless, an exercise approach with the goal of increasing lean tissue, and improving power in knee flexors and flexibility of athletes, should be included in the training program.

  6. Effect of 8 weeks Resistance Training on BDNF and TrkB in the Hippocampus of Adult Male Rats

    Directory of Open Access Journals (Sweden)

    S Mojtahedi

    2014-08-01

    Full Text Available Background & aim: Exercise enhances the synaptic plasticity and neuroprotective effects in the adult brain. However, it remains unknown that how plasticity molecules change following types of training. The purpose of this study was to determine the effect of eight weeks resistance training on protein levels of Brain Derived Neurotrophic Factor(BDNF and receptor of TrkB, in the hippocampus of adult male rats. Methods: In this experimental study, twelve adult male rats, 8 weeks of age, with an average weight of 200 to 225 grams were randomly divided into two groups, control and exercise respectively. The exercise was to increase the weight on the ladder. 24 hours after their last training session. The animals were killed and the hippocampus was removed for further testing. ELISA determined changes in protein levels. Data were analyzed by independent t test. Results: There was a significant difference between train and control groups In protein level of variables statically (p≤0.05. In addition, protein levels of BDNF and TrkB in the hippocampus of rats increased. Conclusion: Resistance training is beneficial for promoting hippocampal plasticity associated with BDNF signaling and consequently functional and cognitive benefits.

  7. Effects of 8 weeks' specific physical training on the rotator cuff muscle strength and technique of javelin throwers.

    Science.gov (United States)

    Kim, Hyeyoung; Lee, Youngsun; Shin, Insik; Kim, Kitae; Moon, Jeheon

    2014-10-01

    [Purpose] For maximum efficiency and to prevent injury during javelin throwing, it is critical to maintain muscle balance and coordination of the rotator cuff and the glenohumeral joint. In this study, we investigated the change in the rotator cuff muscle strength, throw distance and technique of javelin throwers after they had performed a specific physical training that combined elements of weight training, function movement screen training, and core training. [Subjects] Ten javelin throwers participated in this study: six university athletes in the experimental group and four national-level athletes in the control group. [Methods] The experimental group performed 8 weeks of the specific physical training. To evaluate the effects of the training, measurements were performed before and after the training for the experimental group. Measurements comprised anthropometry, isokinetic muscle strength measurements, the function movement screen test, and movement analysis. [Results] After the specific physical training, the function movement screen score and external and internal rotator muscle strength showed statistically significant increases. Among kinematic factors, only pull distance showed improvement after training. [Conclusion] Eight weeks of specific physical training for dynamic stabilizer muscles enhanced the rotator cuff muscle strength, core stability, throw distance, and flexibility of javelin throwers. These results suggest that specific physical training can be useful for preventing shoulder injuries and improving the performance for javelin throwers. PMID:25364111

  8. Effects of 8 Weeks Aerobic Training on the Social-Physical Anxiety in Women with Multiple Sclerosis

    Directory of Open Access Journals (Sweden)

    Forough Rahmati

    2014-07-01

    Full Text Available Nowadays, ailments which are known as specific diseases make the society we live in suffer, and scientific researches pay much attention to the effect of sport and physical activity on these diseases and introduce sports as treatment for them. The purpose of this study was to check the effect of an aerobic training course on social-physical anxiety in women with Multiple Sclerosis (MS. The study population consisted of all inactive women reported by MS community of Tehran in 2012. Of them, 24 ones have been chosen at random (age 32±11 years old and selected in two groups of control and experimental at random. The social-physical anxiety scale (SPAS was used to measure the social-physical anxiety in these patients. The findings indicated a noticeable decrease in the amount of social-physical anxiety in women with MS after 8 weeks of aerobic training (P<0.001. Eventually, we can conclude that aerobic training are effective on decreasing the social-physical anxiety of patients suffering from MS, and it can, by its nature, decrease the social-physical anxiety in these people and promote health and participation in sports activities.

  9. The effects of honey supplementation on seminal plasma cytokines, oxidative stress biomarkers, and antioxidants during 8 weeks of intensive cycling training.

    Science.gov (United States)

    Tartibian, Bakhtyar; Maleki, Behzad Hajizadeh

    2012-01-01

    The purpose of this study was to examine the effects of natural honey supplementation on seminal plasma cytokines, oxidative stress biomarkers, and antioxidants during 8 weeks of intensive cycling training in male road cyclists. Thirty-nine healthy nonprofessional male road cyclists aged 18-28 years participated in this study. The participants were randomly assigned to exercise + supplement (E + S, n = 20) and exercise (E, n = 19) groups. All subjects participated in 8 weeks of intensive cycling training. Ninety minutes before each training session, subjects in the E + S group supplemented with 70 g of honey, whereas subjects in the E group received 70 g of an artificial sweetener. All subjects had an initial semen sampling at baseline (T(1)). The next 6 semen collections were collected immediately (T(2)) and 12 (T(3)) and 24 hours (T(4)) after the last training session in week 4, as well as immediately (T(5)) and 12 (T(6)) and 24 hours (T(7)) after the last training session in week 8, respectively. In the E group, 8 weeks of intensive cycling training significantly increased seminal interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, reactive oxygen species (ROS), and malondialdehyde (MDA) levels (P cycling training would be effective in attenuating the probable aggravating effects of intensive cycling training on spermatogenesis and fertility capacity in road cyclists.

  10. Seizures after stroke : a prospective clinical study.

    Directory of Open Access Journals (Sweden)

    Dhanuka A

    2001-01-01

    Full Text Available Stroke is one of the most common causes of epilepsy in elderly. However, there have been very few prospective studies to define the incidence, pattern and outcome of seizures in stroke. Most studies are based on retrospective analysis of hospital records. Hence, we planned this prospective study to see the clinical, radiological and electroencephalographic characteristics of seizures in stroke and their outcome, from a north Indian tertiary care centre. Over a span of approximately 6 years, 269 consecutive patients with stroke were studied and followed up. Thirty-five (13% of these developed seizures, primarily related to stroke, during mean follow up period of 15.9 months. Twenty of these had infarctions while 15 had haemorrhages. Involvement of the cortical region was seen in most of the patients with seizures. In these patients, 86% of the lesions involved cortical areas exclusively or in addition to subcortical areas on CT scan of the brain. Twenty-seven (77% developed early seizures, two third of them had immediate post-stroke seizures. None of the patients with early onset seizures developed recurrent seizures or epilepsy, while 50% of late onset seizures developed epilepsy. No specific EEG pattern was found in those who later developed epilepsy. In the present study, early onset seizures after stroke were rather common and did not affect outcome and did not recur even when not treated with anti-epileptics. Late onset seizures were less common but were associated with recurrent seizures.

  11. Effect of 8 Weeks of High Intensity Interval Training on Plasma Levels of Adiponectin and Leptin in Overweight Nurses

    Directory of Open Access Journals (Sweden)

    Sahar Avazpor

    2016-07-01

    Full Text Available Background: High intensity interval training (HIIT is a novel training method which has received most attention in recent years. The aim of this study was to examine the effect of 8 weeks of high intensity interval training (HIIT on plasma levels of adiponectin and leptin in overweight nurses.Materials and Methods: 27 nurses (mean age 25.81±60 years, height 158.01±67 cm and weight 69.41±25 kg were voluntarily selected and randomly assigned to three groups (each group 9 subjects: 1. HIIT (type 1 including 8 seconds of sprint running and 12 seconds of active recovery 2. HIIT (type 2 including 40-m shuttle run with maximum speed 3. Control group. HIIT (type 1 was performed for eight weeks, three sessions per week, each session 6-9 min. With more than 90% HRmax. HIIT (type 2 was applied for eight weeks, three sessions per week with more than 90% HRmax. The control group did not participate in any training protocol.Results: The data were analyzed by the dependent t test and ANOVA. The results showed that the HIIT (type 1 and (type 2 had significant effects on plasma leptin decrease and plasma adiponectin concentration increase in nurses. One-way analysis of variance (ANOVA was used to analyze the intergroup data at p˂0.05.Conclusion: The results showed a significant difference in the variables (leptin and adiponectin among HIIT (type 1, HIIT (type 2 and control.

  12. EFFECT OF 8 WEEKS OF AEROBIC OR RESISTANCE TRAINING ON BLOOD PRESSURE IN NON-PHYSICAL EDUCATION MALE STUDENTS

    Directory of Open Access Journals (Sweden)

    Rastegar Hoseini

    2014-01-01

    Full Text Available Aim : Nowadays increasing blood pressure is the most important risk factor of coronary, cerebral and renal vessel diseases. The benefits of aerobic exercise (AE training on blood pressure (BP but the effects of resistance training are less well delineated. The purpose of this study was to determine the impact of resistance or aerobic training on haemodynamics in non-physical education male students. Methods : The target population consisted entirely of male students of University of Guilan. Among them 40 male’s non- athlete were recruited and randomly assigned to 8 weeks of either resistance (RE or AE training. Before and after training, BP, were measured. Statistical analysis was performed by student t – test. Results : The results show that resting systolic BP (SBP decreased following both training modes (SBP: RE, pre 128±1.9 vs post 121±2.3; AE, pre 129±4.2 vs post 123±3.3 mm Hg, P=0.005; diastolic BP: RE, pre 77±2.4 vs post 73±2.1; AE, pre 78±3.4 vs post 74±2.9 mm Hg, P=0.001. Although both RE and AE training decreased BP; were not significant differences among RE and AE training decreased BP. Conclusion : Both RE and AE training decreased BP in non athlete males. Therefore, promotion in physical activity level could be an effective way to decrease hypertension in non-physical education males.

  13. Changes in cerebral blood flow and anxiety associated with an 8-week mindfulness programme in women with breast cancer.

    Science.gov (United States)

    Monti, Daniel A; Kash, Kathryn M; Kunkel, Elisabeth J S; Brainard, George; Wintering, Nancy; Moss, Aleezé S; Rao, Hengyi; Zhu, Senhua; Newberg, Andrew B

    2012-12-01

    This study employed functional magnetic resonance imaging to evaluate changes in cerebral blood flow (CBF) associated with the Mindfulness-based Art Therapy (MBAT) programme and correlate such changes to stress and anxiety in women with breast cancer. Eighteen breast cancer patients were randomized to the MBAT or education control group. The patients received the diagnosis of breast cancer between 6 months and 3 years prior to enrollment and were not in active treatment. The age of participants ranged from 52 to 77 years. A voxel-based analysis was performed to assess differences at rest, during meditation and during a stress task. The anxiety sub-scale of the Symptoms Checklist-90-Revised was compared with changes in resting CBF before and after the programmes. Subjects in the MBAT arm demonstrated significant increases in CBF at rest and during meditation in multiple limbic regions, including the left insula, right amygdala, right hippocampus and bilateral caudate. Patients in the MBAT programme also had a significant correlation between increased CBF in the left caudate and decreased anxiety scores. In the MBAT group, responses to a stressful cue resulted in reduced activation of the posterior cingulate. The results demonstrate that the MBAT programme was associated with significant changes in CBF, which correlated with decreased anxiety over an 8-week period.

  14. Prospective study of definite caterpillar exposures.

    Science.gov (United States)

    Balit, Corrine R; Geary, Merilyn J; Russell, Richard C; Isbister, Geoffrey K

    2003-11-01

    Exposure to caterpillars results in a variety of clinical effects depending on the species involved. The aim of this study was to describe the clinical effects from caterpillar exposures within Australia. Cases were recruited prospectively from calls to a poison information centre. Subjects were included if they had a definite exposure and they had collected the caterpillar or cocoon. The caterpillars were identified to genus and species level where possible. There were 36 included cases: two were contact exposures to caterpillar contents, one was an ingestion of a caterpillar and the remaining 33 patients had definite reactions from caterpillar or cocoon exposure. There were five families of caterpillars identified in the study: Arctiidae, Limacodidae, Anthelidae, Lymantriidae and Sphingidae, many of which occur worldwide. Clinical effects ranged from severe pain to an urticarial response depending on the species involved. There were no adverse effects following ingestion in this study. Treatment consisted primarily of removal of the caterpillar or cocoon. Other treatment measures consisted of symptomatic treatment such as ice packs and antihistamines. This is the first prospective study of caterpillar exposures within Australia and demonstrates that exposures can result in a variety of reactions depending on the family and species involved. PMID:14602121

  15. Changes in the latencies of visual-evoked potentials in people undergoing tennis training Dynamic comparison before and after 8 weeks training

    Institute of Scientific and Technical Information of China (English)

    Jingguo Zhao; Shujuan Pang

    2008-01-01

    BACKGROUND: Some previous studies have shown that exercise is an important factor that affects the latencies of visual-evoked potentials (VEPs).OBJECTIVE: To investigate the effects of spending a period of time undergoing tennis training on the latencies of VEPs by comparing the latencies of VEPs before tennis training with those after 8 weeks of tennis training.DESIGN, TIME AND SETTING: The non-randomly concurrent controlled experiment was performed in the Department of Human Movement Sciences, Physical Education College, Shandong Normal University from April to June 2007.PARTICIPANTS: In total, 45 healthy volunteers from Shandong Normal University were selected as subjects, including 31 students majoring in physical education (11 males and 5 females participated in the tennis training plan for 8 weeks), and 14 students from other subjects. Informed consent was obtained. According to whether they were majoring in physical education or not, and whether or not they took part in tennis training, the students were divided into 3 groups: a tennis group of physical education students (n =16), a non-tennis group of physical education students (n =15) and a non-tennis group of non-physical education students (n =14). METHODS: The subjects in the tennis group took part in a regular tennis training plan of 2 hours a day and 3 days per week, for 8 weeks, while the subjects in two non-tennis groups were not in the tennis training plan. The NDI-200 neural electricity tester (Shanghai Haishen Medical Electronic Instrument Co., Ltd.) was used to measure VEPs before and after the experiment in all three groups, and to compare the latencies of VEPs recorded before training with those recorded after training.MAIN OUTCOME MEASURES: Comparison of the changes in latencies of VEPs before and after 8 weeks of tennis training.RESULTS: All 45 subjects finished the test and datas from all were included in the statistical analysis. There were no significant differences among all the three

  16. Adjunctive Aripiprazole Treatment for Risperidone-Induced Hyperprolactinemia: An 8-Week Randomized, Open-Label, Comparative Clinical Trial.

    Directory of Open Access Journals (Sweden)

    Jingyuan Zhao

    Full Text Available The present study aimed to evaluate the efficacy and safety of adjunctive aripiprazole treatment in schizophrenia patients with risperidone-induced hyperprolactinemia.One hundred and thirteen patients who were receiving a stable dose of risperidone were randomly assigned to either adjunctive aripiprazole treatment (10 mg/day (aripiprazole group or no additional treatment (control group at a 1:1 ratio for 8 weeks. Schizophrenia symptoms were measured using the Positive and Negative Syndrome Scale (PANSS. Rating scales and safety assessments (RSESE, BARS, UKU were performed at baseline and at weeks 4 and 8. Serum levels of prolactin were determined at baseline and at weeks 2, 4, 6 and 8. Metabolic parameters were determined at baseline and again at weeks 4 and 8.One hundred and thirteen patients were enrolled in this study, and 107 patients completed the study (54 in the aripiprazole group, and 53 in the control group. PANSS-total scores in the aripiprazole group decreased significantly at week 4 (P = 0.003 and week 8 (P = 0.007 compared with the control group. PANSS-negative scores in the aripiprazole group also decreased significantly at week 4 (P = 0.005 and week 8 (P< 0.001 compared with the control group. Serum levels of prolactin in the aripiprazole group decreased significantly at week 2 (P< 0.001, week 4 (P< 0.001, week 6 (P< 0.001 and week 8 (P< 0.001 compared with the control group. There were no significant differences in changes of Fasting Plasma Glucose, Total cholesterol, Triglycerides and High Density Lipoprotein within each group at week 4 and 8 execpt low density lipoproteins. There was no significant difference in the incidence of adverse reactions between the two groups.Adjunctive aripiprazole treatment may be beneficial in reducing serum levels of prolactin and improving negative symptoms in schizophrenia patients with risperidone-induced hyperprolactinemia.chictr.org ChiCTR-IOR-15006278.

  17. Predicting residents' performance: A prospective study

    Directory of Open Access Journals (Sweden)

    Ozuah Philip O

    2002-07-01

    Full Text Available Abstract Background Objective criteria for predicting residents' performance do not exist. The purpose of this study was to test the hypothesis that global assessment by an intern selection committee (ISC would correlate with the future performance of residents. Methods A prospective study of 277 residents between 1992 and 1999. Global assessment at the time of interview was compared to subsequent clinical (assessed by chief residents and cognitive performance (assessed by the American Board of Pediatrics in-service training examination. Results ISC ratings correlated significantly with clinical performance at 24 and 36 months of training (r = 0.58, P st, 2nd, and 3rd years of training (r = 0.35, P = .0016; r = 0.39, P = 0.0003; r = 0.50, P = 0.005 respectively. Conclusions Global assessment by an ISC predicted residents' clinical and cognitive performances.

  18. An 8-week brain MRI follow-up analysis of rat eosinophilic meningitis caused by Angiostrongylus cantonensis infection.

    Science.gov (United States)

    Shyu, L Y; Tsai, H H; Lin, D P; Chang, H H; Tyan, Y S; Weng, J C

    2014-09-01

    Early differential diagnosis and timely follow-up are advantageous in the management of Angiostrongylus cantonensis infection. This study aimed to characterize angiostrongyliasis in the rat brain for an 8-week period using magnetic resonance imaging (MRI) with contrast-enhanced T1-weighted images (T1WI), T2-weighted imaging (T2WI), fluid attenuation inversion recovery (FLAIR) and R2 mapping sequences. The data were analysed with Mathematica and Matlab software programs for weekly changes in each brain following the infection of 20, 50, 100 and 300 third-stage larvae (L3), respectively. The results showed that the average subarachnoid space detected by T2WI technique was peaked up to 10% increase of original size on day 35 after 100 or 300 larvae infection, while those infected with 20 or 50 larvae showed less than 4% increase during the entire course of observation. This increase was relevant to the mortality of the infected rats, because those with 100 or 300 larvae infections showed a sharp decrease in survival rate before day 40. After day 40, the average subarachnoid space was decreased, but the average ventricle size was persistently increased, with the highest increase observed in the group infected with 300 larvae on day 56. Furthermore, the R2 mapping mean and R2 mapping size were significantly different between the brains with severe infection (100 and 300 larvae groups together) and those with mild infection (20 and 50 larvae groups together) on day 49, but not on day 35. Our results showed that diagnosis for different quantity of larvae infection using MRI is possible and follow-up characterization is informative in revealing the effects of angiostrongyliasis on different brain areas. In conclusion, our results support the use of MRI as a non-invasive diagnostic technique for eosinophilic meningitis caused by A. cantonensis infection.

  19. The Effect of 8 Weeks of HIT Workouts Plasma Levels of TNF-a, IL-6 and Lipid Profile in Overweight Children

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    Abdolrezareza Kazemi

    2016-03-01

    Full Text Available Introduction: The prevalence of obesity among children and adolescents around the world alarmingly are increasing. Regular exercise can reduce fat tissue and improve body composition. The aim of this study was the effect of the high intensity interval training (HIT on plasma levels of TNF-a, IL-6 and lipid profile in overweight children. Methods: The present study was semi experimental research that performed in Tehran at 2014 year.  In this study, 32 overweight students 8 to 11 divided in the experimental (n=16 and control (n=16 group. High intensity interval training including 30 seconds with maximum speed and 5.1 minutes rest was performed for 8 weeks and 3 sessions per week. The six HIT workouts in the first week increased to 10 to last week. Blood samples were collected from venous blood of right hand 48 hours last session. ANCOVA test performed for compared of variable mean (α=0.005. Results: The results of the present study showed that 8 weeks HIT significantly reduced level of IL-6 (P=0.001, TNF-a (P=0.001 and lipid profile. On the other hand, there was insignificantly change in TG (P=0.777, LDL (P=0.071 and HDL (P=0.693. Conclusion: The findings of this study showed that 8 weeks HIT reduces the plasma level of TNF-a and IL-6. Therefore, perform of high intensity interval training with observed necessaryw55 caution in obese children can have positive effects.

  20. The Effect of 8-week Aerobic and Concurrent (aerobic- resistance Exercise Training on Serum IL-6 Levels and Insulin Resistance in Type 2 Diabetic Patients

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    P Yousefipoor

    2013-12-01

    Full Text Available Introductoin: Increased level of serum IL-6 is related to development of type 2 diabetes and insulin resistance. The American Diabetes Association and the American College of Sports Medicine recommend that combination of resistance and aerobic exercise is favorable for patients with type 2 diabetes. The purpose of this study was to investigate the effect of 8 weeks of aerobic exercise and concurrent (aerobic-resistance exercise on serum IL-6 Levels and insulin resistance in Type 2 Diabetic patients. Methods: In this study, from patients referring to Kermanshah Diabetes Association, 24 volunteers participated in the study as subjects and were divided into aerobic (n=8, concurrent (n=8, and control group (n=8 randomly. Training program for the aerobic group included 3 sessions of running per week with 60 to 80% maximal heart rate for 8 weeks but the concurrent group in addition to running, performed resistance training of major muscles groups. Before and after the intervention, body weight, BMI, fasting blood glucose, serum IL-6 and HOMA-IR were measured. Results: HOMA-IR and fasting blood glucose were significantly decreased in both training groups after intervention, but showed no significant changes in the control group. No significant changes were observed for serum IL-6 levels, body weight or BMI. Conclusion: performing 8 weeks of aerobic or concurrent training with improvement of insulin resistance and fasting blood glucose could be helpful for type 2 diabetic patients; however, it cannot significantly affect serum IL-6 levels, body weight, or BMI in these patients.

  1. ADOLESCENT GYNAECOLOGICAL PROBLEMS: A PROSPECTIVE STUDY

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    Prakriti

    2015-12-01

    Full Text Available CONTEXT/BACKGROUND Adolescence, meaning “To grow up,” is a transitional stage of physical, sexual and mental human development occurring between puberty and legal adulthood. The Government of India in National Youth Policy defines adolescents as individuals between 13 to 19 yrs. of age. AIMS To study the magnitude of different adolescent gynecological problems in patients attending OPD of GRMC, Gwalior, MP. SETTINGS AND DESIGN Prospective study in patients attending gynecological OPD of GRMC, Gwalior, MP. SAMPLE SIZE: 75 METHODS AND MATERIALS Seventy five adolescent girls in the age group of 13-19 yrs. attending gynecological OPD of GRMC, Gwalior, from November 2013 to October 2014 were included in the study. Detailed history, general examinations and investigations were done to evaluate their health. STATISTICAL ANALYSIS Was done using Microsoft Excel. RESULTS Incidence of gynecological problem in our study was 3.33%. Different gynecological problems were menstrual disorders (60%, leucorrhoea (10.66%, infections (8%, ovarian cyst (5.33%, sexual assault (2.66%, teenage pregnancy (10.66% and infertility (2.66%. Majority of girls with menstrual disorders suffered from puberty menorrhagia (55.55%. Dysfunctional uterine bleeding was diagnosed in 96% of girls suffering from puberty menorrhagia. Pelvic Inflammatory Disease was exclusively seen in married adolescent girls. Vaginal atresia and imperforate hymen were causes of primary amenorrhoea. PCOD was commonest cause of secondary amenorrhoea amongst adolescents. CONCLUSION Menstrual abnormalities are the most common problems of adolescent girls. Setting up adolescent clinics is desirable.

  2. Ossiculoplasty: A Prospective Study of 80 Cases

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    Shrinivas Shripatrao Chavan

    2014-07-01

    Full Text Available Introduction: The use of ossicular graft material in ossicular chain reconstruction has significantly improved hearing results hearing after tympanoplasty and tympanomastoid surgery for chronic otitis media. Today, otologists have a wide array of tools from which to choose, but may find it difficult to know which middle ear implant works best.   Materials and Methods: A prospective study of 80 patients who underwent ossiculoplasty was performed in the ear, nose, and throat (ENT department at a tertiary health care facility from 2011 to 2013. Patients with chronic suppurative otitis media with an air-bone gap (ABG of >25 dB with ossicular involvement were included in the study. Total ossicular replacement prosthesis (TORP, partial ossicular replacement prosthesis (PORP, and refashioned incus were used. Success was defined as ABG   Results: The majority patients were of middle age with moderate conductive hearing loss. Incus was the most susceptible ossicle. Overall success rate in this study was 80.0% with an average change of 15.76 dB in ABG.   Conclusion:  With continuing advances in our understanding of middle ear mechanics, the results of ossiculoplasty are improving and results can be very rewarding in experienced hands. Severity of preoperative ear discharge, preoperative mastoid cellularity, presence of disease, and surgical procedure proved to be significant prognostic factors. Autograft incus and PORP fared better when the malleus handle was present while TORP gave better results when the malleus handle was eroded.

  3. Ossiculoplasty: A Prospective Study of 80 Cases

    Directory of Open Access Journals (Sweden)

    Shrinivas Shripatrao Chavan

    2014-07-01

    Full Text Available Introduction: The use of ossicular graft material in ossicular chain reconstruction has significantly improved hearing results hearing after tympanoplasty and tympanomastoid surgery for chronic otitis media. Today, otologists have a wide array of tools from which to choose, but may find it difficult to know which middle ear implant works best.   Materials and Methods: A prospective study of 80 patients who underwent ossiculoplasty was performed in the ear, nose, and throat (ENT department at a tertiary health care facility from 2011 to 2013. Patients with chronic suppurative otitis media with an air-bone gap (ABG of >25 dB with ossicular involvement were included in the study. Total ossicular replacement prosthesis (TORP, partial ossicular replacement prosthesis (PORP, and refashioned incus were used. Success was defined as ABG   Results: The majority patients were of middle age with moderate conductive hearing loss. Incus was the most susceptible ossicle. Overall success rate in this study was 80.0% with an average change of 15.76 dB in ABG.   Conclusion:  With continuing advances in our understanding of middle ear mechanics, the results of ossiculoplasty are improving and results can be very rewarding in experienced hands. Severity of preoperative ear discharge, preoperative mastoid cellularity, presence of disease, and surgical procedure proved to be significant prognostic factors. Autograft incus and PORP fared better when the malleus handle was present while TORP gave better results when the malleus handle was eroded.  

  4. EPR Dosimetry: an update and prospective studies

    International Nuclear Information System (INIS)

    kGy for thermal neutron flux. The radiation induced radical signal was found to be stable over a period of 300 days with marginal fading of 2C2O4: Na2C2O4 mixture as the potential neutron dosimeter for high range dosimetry. The effect of gamma dose irradiation on sodium succinate was studied by EPR technique. It was observed that the radiation induced CO3- radical (g = 2.00357) as linear in signal - dose response, in 35 Gy - 4.4 kGy. Thus, sodium succinate powder samples could be used in EPR dosimetry, since CO3- radicals have been found stable for more than 6 months, post-irradiation. Solid State Nuclear Track Detector (SSNTD) material Tuffak polycarbonate film was studied for prospective EPR dosimetry, feasibility studies were carried out on gamma irradiated SSNTD film. The first derivative EPR spectra of irradiated Tuffak polycarbonate samples contained a singlet, signal at g = 2.00415. The signal was identified as CO33- from earlier reports. The EPR signal intensity of CO33- (g = 2.00415) was found linear in signal - dose response in 10 - 80 kGy. The present paper gives an update of newer EPR dosimetric materials that have been investigated, after a brief introduction to the basic principles of EPR. Further, prospective dosimetric materials with their suitability for applications in EPR dosimetry have been discussed. (author)

  5. Prehospital airway management: A prospective case study.

    Science.gov (United States)

    Wilbers, N E R; Hamaekers, A E W; Jansen, J; Wijering, S C; Thomas, O; Wilbers-van Rens, R; van Zundert, A A J

    2011-01-01

    We conducted a one-year prospective study involving a prehospital Emergency Medical Service in the Netherlands to investigate the incidence of failed or difficult prehospital endotracheal intubation. During the study period the paramedics were asked to fill in a registration questionnaire after every endotracheal intubation. Of the 26,271 patient contacts, 256 endotracheal intubations were performed by paramedics in one year. Endotracheal intubation failed in 12 patients (4.8%). In 12.0% of 249 patients, a Cormack and Lehane grade III laryngoscopy was reported and a grade IV laryngoscopy was reported in 10.4%. The average number of endotracheal intubations per paramedic in one year was 4.2 and varied from zero to a maximum of 12. The median time between arrival on the scene and a positive capnograph was 7 min.38 s in the case of a Cormack and Lehane grade I laryngoscopy and 14 min.58 s in the case of a Cormack and Lehane grade 4 laryngoscopy. The incidence of endotracheal intubations performed by Dutch paramedics in one year was low, but endotracheal intubation was successful in 95.2%, which is comparable with findings in international literature. Early capnography should be used consistently in prehospital airway management. PMID:21612142

  6. Adjunctive Aripiprazole Treatment for Risperidone-Induced Hyperprolactinemia: An 8-Week Randomized, Open-Label, Comparative Clinical Trial

    Science.gov (United States)

    Zhao, Jingyuan; Song, Xueqin; Ai, Xiaoqing; Gu, Xiaojing; Huang, Guangbiao; Li, Xue; Pang, Lijuan; Ding, Minli; Ding, Shuang; Lv, Luxian

    2015-01-01

    Objective The present study aimed to evaluate the efficacy and safety of adjunctive aripiprazole treatment in schizophrenia patients with risperidone-induced hyperprolactinemia. Methods One hundred and thirteen patients who were receiving a stable dose of risperidone were randomly assigned to either adjunctive aripiprazole treatment (10 mg/day) (aripiprazole group) or no additional treatment (control group) at a 1:1 ratio for 8 weeks. Schizophrenia symptoms were measured using the Positive and Negative Syndrome Scale (PANSS). Rating scales and safety assessments (RSESE, BARS, UKU) were performed at baseline and at weeks 4 and 8. Serum levels of prolactin were determined at baseline and at weeks 2, 4, 6 and 8. Metabolic parameters were determined at baseline and again at weeks 4 and 8. Results One hundred and thirteen patients were enrolled in this study, and 107 patients completed the study (54 in the aripiprazole group, and 53 in the control group). PANSS-total scores in the aripiprazole group decreased significantly at week 4 (P = 0.003) and week 8 (P = 0.007) compared with the control group. PANSS-negative scores in the aripiprazole group also decreased significantly at week 4 (P = 0.005) and week 8 (P< 0.001) compared with the control group. Serum levels of prolactin in the aripiprazole group decreased significantly at week 2 (P< 0.001), week 4 (P< 0.001), week 6 (P< 0.001) and week 8 (P< 0.001) compared with the control group. There were no significant differences in changes of Fasting Plasma Glucose, Total cholesterol, Triglycerides and High Density Lipoprotein within each group at week 4 and 8 execpt low density lipoproteins. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusions Adjunctive aripiprazole treatment may be beneficial in reducing serum levels of prolactin and improving negative symptoms in schizophrenia patients with risperidone-induced hyperprolactinemia. Trial Registration chictr.org Chi

  7. Neurosurgery in rural Nigeria: A prospective study

    Science.gov (United States)

    Rabiu, Taopheeq Bamidele; Komolafe, Edward Oluwole

    2016-01-01

    Background: Africa has very few neurosurgeons. These are almost exclusively in urban centers. Consequently, people in rural areas, most of the African population, have poor or no access to neurosurgical care. We have recently pioneered rural neurosurgery in Nigeria. Objectives: This report details our initial experiences and the profile of neurosurgical admissions in our center. Methods: A prospective observational study of all neurosurgical patients managed at a rural tertiary health institution in Nigeria from December 2010 to May 2012 was done. Simple descriptive data analysis was performed. Results: A total of 249 males (75.2%) and 82 females (24.8%) were managed. The median age was 37 years (range: Day of birth – 94 years). Trauma was the leading cause of presentation with 225 (68.0%) and 35 (10.6%) having sustained head and spinal injuries, respectively. Operative intervention was performed in 54 (16.3%). Twenty-four (7.2%) patients discharged against medical advice, mostly for economic reasons. Most patients (208, 63.4%) had satisfactory outcome while 30 (9.1%) died. Conclusion: Trauma is the leading cause of rural neurosurgical presentations. There is an urgent need to improve access to adequate neurosurgical care in the rural communities.

  8. Child cyclist injuries: a prospective study.

    Science.gov (United States)

    Armson, C J; Pollard, C W

    1986-02-01

    A prospective study of pedalcycle accident morbidity and mortality was carried out from February to mid-November 1983 because of the high frequency of child cyclist injuries that were occurring on the relatively flat Redcliffe Peninsula. These injuries were apparently associated with the large number of young children who use a bicycle as their main mode of transport to and from school. The schools were surveyed for the extent of bicycle use and cyclists were surveyed for the amount of protective clothing that was worn while involved in cycling. It was found that a disturbingly large number of young children made regular bicycle trips on public roads with the minimal use of safety helmets or any other form of protective clothing. Nearly 40% of on-road accidents involved children of less than 12 years of age, and over 10% of these involved children of six years of age or less. No child in our series of on-road accidents was, at the time of injury, wearing a safety helmet or any other form of protective clothing. No bicycle accidents occurred on the exclusive cycle track of approximately 1 km in length on the Peninsula.

  9. The Effect of 8 Weeks Endurance Training on Serum Levels of IL-10 and IL-8, and White Blood Cell Count in Women with Breast Cancer

    Directory of Open Access Journals (Sweden)

    Abdolreza Kazemi

    2016-09-01

    Full Text Available Background & Objective: The regular exercise training is known as a preventive and adjuvant therapy in inflammatory diseases such as cancer. The aim of this study was to determine the effect of the aerobic training on IL-10 and IL-8 levels and the count of white blood cells (WBC in women with breast cancer. Material & Methods: The statistical society of the present study included Kerman women with breast cancer. Forty patients with breast cancer were randomly divided into two groups: exercise (n = 20 and control (n = 20. The exercise group performed the endurance training for 8 weeks with the intensity between 40 to 55 percent of the target heart rate. Twenty four hours before the first session and 48 hours after the last session of the exercise protocol, blood samples were taken from both groups and then IL-10 and IL-8 levels in serum were measured by ELISA via a Boster kit. Results: The results of the present study showed that 8 weeks of the endurance exercise training did not significantly increase the IL-10 (P=0.113 serum level, but increased the WBC count (p=0.019 and decreased the serum level of IL-8 (p=0.03 significantly. Conclusion: According to the results of the present study, regular endurance training via decreasing the inflammatory factors can be considered as an effective factor along with other therapies in improving breast cancer.

  10. Regular consumption of pulses for 8 weeks reduces metabolic syndrome risk factors in overweight and obese adults.

    Science.gov (United States)

    Mollard, R C; Luhovyy, B L; Panahi, S; Nunez, M; Hanley, A; Anderson, G H

    2012-08-01

    Pulses are low in energy density, supporting their inclusion in the diet for the management of risk factors of the metabolic syndrome (MetSyn). The aim of the present study was to describe the effects of frequent consumption (five cups/week over 8 weeks) of pulses (yellow peas, chickpeas, navy beans and lentils), compared with counselling to reduce energy intake by 2093 kJ/d (500 kcal/d), on risk factors of the MetSyn in two groups (nineteen and twenty-one subjects, respectively) of overweight or obese (mean BMI 32·8 kg/m2) adults. Body weight, waist circumference, blood pressure, fasting blood parameters and 24 h food intakes were measured at weeks 1, 4 and 8. Blood glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1) and ghrelin were measured after a 75 g oral glucose load at weeks 1 and 8. At week 8, both groups reported reductions in energy intake, waist circumference, systolic blood pressure, glycosylated Hb (HbA1c) and glucose AUC and homeostasis model of insulin resistance (HOMA-IR) following the glucose load (P < 0·05). However, HDL, fasting C-peptide and insulin AUC responses were dependent on diet (P < 0·05). HDL and C-peptide increased by 4·5 and 12·3 %, respectively, in the pulse group, but decreased by 0·8 and 7·6 %, respectively, in the energy-restricted group. Insulin AUC decreased in both females and males on the energy-restricted diet by 24·2 and 4·8 %, respectively, but on the pulse diet it decreased by 13·9 % in females and increased by 27·3 % in males (P < 0·05). In conclusion, frequent consumption of pulses in an ad libitum diet reduced risk factors of the MetSyn and these effects were equivalent, and in some instances stronger, than counselling for dietary energy reduction. PMID:22916807

  11. Positive Modulation Effect of 8-Week Consumption of Kaempferia parviflora on Health-Related Physical Fitness and Oxidative Status in Healthy Elderly Volunteers

    Directory of Open Access Journals (Sweden)

    Jintanaporn Wattanathorn

    2012-01-01

    Full Text Available Health-related physical fitness declines as the age advances. Oxidative stress is reported to contribute the crucial role on this phenomenon. This condition is also enhanced by antioxidant. Therefore, we aimed to determine the effect of Kaempferia parviflora, a plant reputed for antifatigue, longevity promotion, and antioxidant effects, on health-related quality physical fitness and oxidative status of the healthy elderly volunteers. Total 45 subjects had been randomized to receive placebo or K. parviflora extract at doses of 25 or 90 mg once daily for 8 weeks. They were determined baseline data of physical performance using 30 sec chair stand test, hand grip test, 6 min walk test, and tandem test. Serum oxidative stress markers including malondialdehde (MDA level and the activities of superoxide dismutase (SOD, catalase (CAT, and glutathione peroxidase (GSH-Px were also assayed. All assessments were performed every 4 weeks throughout the 8-week study period. The results showed that K. parviflora increased performance in 30-second chair stand test and 6 min walk test together with the increased all scavenger enzymes activities and the decreased MDA level. Therefore, K. parviflora can enhance physical fitness partly via the decreased oxidative stress. In conclusion, K. parviflora is the potential health supplement for elderly. However, further study is required.

  12. Positive Modulation Effect of 8-Week Consumption of Kaempferia parviflora on Health-Related Physical Fitness and Oxidative Status in Healthy Elderly Volunteers.

    Science.gov (United States)

    Wattanathorn, Jintanaporn; Muchimapura, Supaporn; Tong-Un, Terdthai; Saenghong, Narisara; Thukhum-Mee, Wipawee; Sripanidkulchai, Bungorn

    2012-01-01

    Health-related physical fitness declines as the age advances. Oxidative stress is reported to contribute the crucial role on this phenomenon. This condition is also enhanced by antioxidant. Therefore, we aimed to determine the effect of Kaempferia parviflora, a plant reputed for antifatigue, longevity promotion, and antioxidant effects, on health-related quality physical fitness and oxidative status of the healthy elderly volunteers. Total 45 subjects had been randomized to receive placebo or K. parviflora extract at doses of 25 or 90 mg once daily for 8 weeks. They were determined baseline data of physical performance using 30 sec chair stand test, hand grip test, 6 min walk test, and tandem test. Serum oxidative stress markers including malondialdehde (MDA) level and the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) were also assayed. All assessments were performed every 4 weeks throughout the 8-week study period. The results showed that K. parviflora increased performance in 30-second chair stand test and 6 min walk test together with the increased all scavenger enzymes activities and the decreased MDA level. Therefore, K. parviflora can enhance physical fitness partly via the decreased oxidative stress. In conclusion, K. parviflora is the potential health supplement for elderly. However, further study is required. PMID:22899957

  13. A prospective study of the incidence and nature of injuries to adult rugby players.

    Science.gov (United States)

    Clark, D R; Roux, C; Noakes, T D

    1990-06-01

    The incidence and nature of injuries occurring in 8 adult club rugby teams was followed prospectively during the 1988 rugby season. The findings were compared with those from two similar studies in schoolboy rugby players. A total of 114 injuries were sustained by 78 players; 85% of injuries occurred during matches. Injury was most prevalent during the first 8 weeks of the season and again after the mid-season break. Hookers (19%), wings (15%), fullbacks (11%) and centres (10%) were the players most often injured. Injury occurred most commonly when the player was tackled (26%), during open play (21%) and during the loose scrum (17%). Muscles (33%) and ligaments (32%) were the anatomical structures most often injured. Injury caused 35% of injured players to miss more than 35 days of rugby. Thirteen per cent of injured players did not play again for the rest of the season and only 14% of injured players returned to rugby after 7 days or less. Prolonged disability was associated with ligament injuries (57%), dislocations (17%) and fractures (10%). PMID:2345880

  14. A Prospective Study of Adolescent Pregnancy.

    Science.gov (United States)

    Hockaday, Cathy; Crase, Sedahlia Jasper; Shelley, Mack C., II; Stockdale, Dahlia F.

    2000-01-01

    Examines prospectively the characteristics contributing to adolescent pregnancy in a pregnant and comparison group of adolescents. Adolescent pregnancy in Blacks was predicted by approval of delaying a family and pursuing a career, aspirations of working, and lower educational expectations. Higher educational wishes, lower educational…

  15. Effects of dietary creatine supplementation for 8 weeks on neuromuscular coordination and learning in male albino mouse following neonatal hypoxic ischemic insult.

    Science.gov (United States)

    Iqbal, Shahid; Ali, Muhammad; Akbar, Atif; Iqbal, Furhan

    2015-05-01

    Creatine monohydrate (Cr) is a dietary supplement known to improve cognitive functions and has positive therapeutic results under various clinical conditions. The aim of this study was to determine the effect of 2 % Cr supplementation on learning, memory formation, neuromuscular coordination, exploratory and locomotory in male albino mice following hypoxic ischemic insult. At postnatal day, 10 male albino mice pups were subjected to right common carotid artery ligation followed by 8 % hypoxia for 25 min. On postnatal day 20, male mice were separated from the litter and divided into two groups on the basis of special diet supplementation. One group was supplemented with 2 % Cr in diet while the other group was raised on ordinary rodent chow for 8 weeks. Behavioral observations were made during rota rod, open field and Morris water maze test for both treatments. It was observed that supplementation with 2 % Cr for 8 weeks following neonatal brain damage resulted in enhanced muscular strength, neuromuscular coordination and improved body weight. In Morris water maze test, it was observed that Cr supplementation significantly improved mean swimming speed and mice on 2 % Cr diet covered more distance but the spatial memory was not improved significantly following hypoxia ischemia encephalopathy (HIE). Open field parameters and percentage of infarct volume remained unaffected following Cr supplementation. We concluded that 2 % dietary Cr supplementation has a potential to improve the muscle strength and body weight in male albino mice following (HIE) and should be considered for the treatment of neurological ailments. PMID:25511980

  16. Growth rate, health and welfare in a dairy herd with natural suckling until 6–8 weeks of age: a case report

    Directory of Open Access Journals (Sweden)

    Mejdell Cecilie

    2007-06-01

    Full Text Available Abstract Over a period of two years, growth rate and health were measured for dairy calves allowed to suckle their mothers up to 6–8 weeks of age. Thirty-one calves were weighted weekly, and the mean daily growth rate was 1.2 ± 0.03 kg from birth up to 13 weeks of age. Illness in calves and young stock was not observed. In the cows, the mean incidences of ketosis, displaced abomasum, puerperal paresis, mastitis, teat injury and retained placenta were 0, 0, 8, 22, 1 and 1%, respectively, during a 6-year period. The mean daily gain of 56 growing bulls was 1.4 kg when slaughtered at 15 months of age, which is higher than the mean daily gain of 0.95 kg in the population. Probiotics, hormones and vaccines were not used, and antibiotics were only used for treating illness. The present study indicates many advantages and few problems when dairy calves are penned together with the cows and allowed natural feeding up to 6–8 weeks of age. This production system was easy to manage, preferred by the farmer, and may satisfy the public concern regarding the practice of immediate separation of cow and calf in commercial milk production.

  17. Prospective Chemistry Teachers’ Understanding of Boiling: A Phenomenological Study

    OpenAIRE

    CANPOLAT, Nurtaç; PINARBAŞI, Tacettin

    2012-01-01

    This study investigates chemistry prospective teachers’ views regarding boiling phenomenon, and provides a concept analysis on the nature of boiling together with suggestions on how to teach boiling phenomenon in the light of literature and findings of this study. The sample of this study consists of 18 senior prospective chemistry teachers who attend chemistry teacher training program. Data were collected by discussions with the participants. The discussions were specifically focused on pros...

  18. A prospective study of predictors of depression symptoms in police

    OpenAIRE

    Wang, Zhen; Inslicht, Sabra S.; Metzler, Thomas J.; Henn-Haase, Clare; McCaslin, Shannon E.; Tong, Huiqi; Neylan, Thomas C.; Marmar, Charles R.

    2009-01-01

    Police work is one of the most stressful occupations. Previous research has indicated that work stress and trauma exposure may place individuals at heightened risk for the development of depression symptomatology. This prospective longitudinal study was designed to examine predictors of depression symptoms in police service.119 healthy police recruits from an ongoing prospective study were examined. Participants completed baseline measures of depression symptoms, childhood trauma exposure, ne...

  19. Reduction of abdominal fat accumulation in rats by 8-week ingestion of a newly developed sweetener made from high fructose corn syrup.

    Science.gov (United States)

    Iida, Tetsuo; Yamada, Takako; Hayashi, Noriko; Okuma, Kazuhiro; Izumori, Ken; Ishii, Reika; Matsuo, Tatsuhiro

    2013-06-01

    Many studies have shown that ingestion of high-fructose corn syrup (HFCS) may cause an increase in body weight and abdominal fat. We recently developed a new sweetener containing rare sugars (rare sugar syrup; RSS) by slight isomerization of HFCS. Here, the functional effects of RSS on body weight and abdominal fat, and biochemical parameters in Wistar rats were examined. Rats (n=30) were randomly divided into three groups and maintained for 8-weeks on starch, starch+HFCS (50:50), and starch+RSS (50:50) diets. Rats in the Starch and HFCS groups gained significantly more body weight and abdominal fat than the RSS group. Fasting serum insulin in the RSS group was significantly lower than in the Starch and HFCS groups, although serum glucose in the HFCS and RSS groups was significantly lower than that in the Starch group. Thus, the substitution of HFCS with RSS prevents obesity induced by the consumption of HFCS.

  20. Reduction of abdominal fat accumulation in rats by 8-week ingestion of a newly developed sweetener made from high fructose corn syrup.

    Science.gov (United States)

    Iida, Tetsuo; Yamada, Takako; Hayashi, Noriko; Okuma, Kazuhiro; Izumori, Ken; Ishii, Reika; Matsuo, Tatsuhiro

    2013-06-01

    Many studies have shown that ingestion of high-fructose corn syrup (HFCS) may cause an increase in body weight and abdominal fat. We recently developed a new sweetener containing rare sugars (rare sugar syrup; RSS) by slight isomerization of HFCS. Here, the functional effects of RSS on body weight and abdominal fat, and biochemical parameters in Wistar rats were examined. Rats (n=30) were randomly divided into three groups and maintained for 8-weeks on starch, starch+HFCS (50:50), and starch+RSS (50:50) diets. Rats in the Starch and HFCS groups gained significantly more body weight and abdominal fat than the RSS group. Fasting serum insulin in the RSS group was significantly lower than in the Starch and HFCS groups, although serum glucose in the HFCS and RSS groups was significantly lower than that in the Starch group. Thus, the substitution of HFCS with RSS prevents obesity induced by the consumption of HFCS. PMID:23411176

  1. Dropout from exercise programs for seniors: A prospective cohort study

    NARCIS (Netherlands)

    Stiggelbout, M.; Hopman-Rock, M.; Tak, E.; Lechner, L.; Mechelen, W. van

    2005-01-01

    This study examines dropout incidence, moment of dropout, and switching behavior in organized exercise programs for seniors in the Netherlands, as determined in a prospective cohort study (with baseline measurements at the start of the exercise program and follow-up after 6 months; N = 1,725, respon

  2. Determinants of depression in chronic stroke : A prospective cohort study

    NARCIS (Netherlands)

    van de Port, Ingrid G. L.; Kwakkel, Gert; Bruin, Margje; Lindeman, Eline

    2007-01-01

    Purpose. The aim of the study was to identify factors that are significantly related to depression in chronic stroke patients. Methods. Prospective cohort study of stroke patients admitted for rehabilitation. A total of 165 first ever stroke patients over 18 years of age were assessed at one and thr

  3. Posttransfusion survival of red cells frozen for 8 weeks after 42-day liquid storage in AS-3

    International Nuclear Information System (INIS)

    Current standards recommend that red cells (RBCs) should be frozen within 6 days of donation. There are situations, however, in which it is desirable to freeze RBCs that are older than 6 days, such as for the salvage of rare or autologous units. To determine the therapeutic efficacy of RBCs frozen after prolonged liquid storage, standard units were drawn from nine normal donors and stored at 4 degrees C for 42 days in a nutrient-additive solution, AS-3. 51CrRBC survival assays were performed (24-hour survival: 78.2 +/- 12.4%; n = 8) and the units were frozen at -80 degrees C in glycerol for 8 weeks. After deglycerolization, the mean RBC recovery was 81.0 +/- 4.1 percent and the mean 24-hour 51Cr survival was 78.0 +/- 9.1 percent. The index of therapeutic effectiveness (ITE) was determined by multiplying the postdeglycerolization 24-hour 51Cr survival by the mean RBC recovery (63.3 +/- 9.2). ITE values greater than 60 percent (75% 51Cr survival x 80% RBC recovery) were considered acceptable. Mean adenosine triphosphate levels declined from an initial 3.81 +/- 0.56 micromol per g of hemoglobin to 2.33 +/- 0.55 micromol per g after frozen storage. These findings show that an acceptable percentage of RBCs survives frozen storage after maximum liquid storage (mean ITE greater than 60%). If necessary, RBCs stored in AS-3 can be frozen at any time before 42 days

  4. Personality and substance use disorders: a prospective study.

    Science.gov (United States)

    Sher, K J; Bartholow, B D; Wood, M D

    2000-10-01

    The personality systems of Cloninger (as measured by the Tridimensional Personality Questionnaire [TPQ]) and Eysenck (as measured by the Eysenck Personality Questionnaire [EPQ]) both have been linked to substance use and abuse. The current study examined the predictive utility of both systems for substance use disorder (SUD) diagnoses, both cross-sectionally and prospectively. Participants (N = 489 at baseline) completed the EPQ and TPQ and were assessed via structured diagnostic interview at baseline and 6 years later (N = 457 at follow-up). Both the EPQ and TPQ scales demonstrated bivariate cross-sectional and prospective associations with SUDs. Within each system, those dimensions marking a broad impulsive sensation-seeking or behavioral disinhibition trait were the best predictors prospectively, although the 2 systems were differentially sensitive to specific diagnoses. These relations remained significant even with autoregressivity, other concurrent SUD diagnoses, and multiple personality dimensions statistically controlled.

  5. Effect of levan supplement in orange juice on weight, gastrointestinal symptoms and metabolic profile of healthy subjects: results of an 8-week clinical trial.

    Science.gov (United States)

    Niv, Eva; Shapira, Yami; Akiva, Ira; Rokhkind, Evgenia; Naor, Etty; Arbiv, Mira; Vaisman, Nachum

    2012-07-01

    Levan is a commonly used dietary fiber of the fructans group. Its impact on health remains undetermined. This double blind controlled study aimed to investigate the effect of 8 weeks' daily consumption of 500 mL of natural orange juice enriched with 11.25 g of levan compared to the same amount of natural orange juice without levan on weight, gastrointestinal symptoms and metabolic profiles of 48 healthy volunteers. The statistical analyses compared between- and within-group findings at baseline, 4 weeks and study closure. The compared parameters were: weight, blood pressure, blood laboratory tests, daily number of defecations, scores of stool consistency, abdominal pain, bloating, gas, dyspepsia, vomiting and heartburn. Despite a higher fiber level recorded in the study group, there was no significant difference in the effect of the two kinds of juices on the studied parameters. Both juices decreased systolic and diastolic pressures, increased sodium level (within normal range), stool number, and bloating scores, and decreased gas scores. In conclusion, levan itself had no effect on weight, gastrointestinal symptoms or metabolic profile of healthy volunteers. Its possible effect on obese, hypertensive or hyperlipidemic patients should be investigated in further studies. PMID:22852055

  6. Unexpected allergic reactions to food, a prospective study

    NARCIS (Netherlands)

    Michelsen-Huisman, A.D.; Os-Medendorp, H. van; Versluis, A.; Kruizinga, A.G.; Castenmiller, J.J.M.; Noteborn, H.P.J.M.; Houben, G.F.; Knulst, A.C.

    2013-01-01

    Unexpected reactions occur in patients with food allergy, but frequency data are scare. This prospective study investigates the frequency, severity and causes of unexpected allergic reactions to food in adults with a doctor's diagnosed food allergy. Participants complete an online questionnaire afte

  7. A Prospective Study of Perception in Adolescent Smoking

    NARCIS (Netherlands)

    Otten, R.; Engels, R.C.M.E.; Prinstein, M.J.

    2009-01-01

    Purpose - This prospective study examined how environmental smoking affects the perception of lifetime smoking prevalence and thereby the likelihood of subsequent regular smoking. Methods - A longitudinal design (N = 6769) with three waves was used to test our research questions. Exposure to smoking

  8. Development in Children with Achondroplasia: A Prospective Clinical Cohort Study

    Science.gov (United States)

    Ireland, Penelope J.; Donaghey, Samantha; McGill, James; Zankl, Andreas; Ware, Robert S.; Pacey, Verity; Ault, Jenny; Savarirayan, Ravi; Sillence, David; Thompson, Elizabeth; Townshend, Sharron; Johnston, Leanne M.

    2012-01-01

    Aim: Achondroplasia is characterized by delays in the development of communication and motor skills. While previously reported developmental profiles exist across gross motor, fine motor, feeding, and communication skills, there has been no prospective study of development across multiple areas simultaneously. Method: This Australasian…

  9. Prospective Study of the Effectiveness of Coping in Pediatric Patients

    Science.gov (United States)

    Zehnder, Daniel; Prchal, Alice; Vollrath, Margarete; Landolt, Markus A.

    2006-01-01

    Findings about the influence of coping on psychological adjustment in children with different medical conditions are inconsistent and often based on cross-sectional data. This prospective study evaluated the effect of various coping strategies on children's post-traumatic stress symptoms and behavioral problems 1 month and 1 year after an…

  10. The Early Growth and Development Study: A Prospective Adoption Design

    OpenAIRE

    Leve, Leslie D; Neiderhiser, Jenae M.; Ge, Xiaojia; Scaramella, Laura V.; Conger, Rand D.; Reid, John B.; Shaw, Daniel S.; Reiss, David

    2007-01-01

    The Early Growth and Development Study is a prospective adoption study of birth parents, adoptive parents, and adopted children (N = 350 triads) that was initiated in 2003. The primary study aims are to examine how family processes mediate or moderate the expression of genetic influences in order to aid in the identification of specific family processes that could serve as malleable targets for intervention. Participants in the study were recruited following the birth of the child through ado...

  11. Statistical principles for prospective study protocols:

    DEFF Research Database (Denmark)

    Christensen, Robin; Langberg, Henning

    2012-01-01

    In the design of scientific studies it is essential to decide on which scientific questions one aims to answer, just as it is important to decide on the correct statistical methods to use to answer these questions. The correct use of statistical methods is crucial in all aspects of research to qu...

  12. Prostate, Lung, Colon, and Ovary Prospective Study

    Science.gov (United States)

    A large cohort study of etiologic determinants of cancer carried out within an NCI trial for the evaluation of screening procedures for the early detection of prostate, lung, colon, and ovarian cancer (the PLCO Trial) at 10 U.S. screening centers

  13. Migraine and Cognitive Decline Among Women: Prospective Cohort Study

    OpenAIRE

    Rist, Pamela Marie; Kang, Jae Hee Hee; Buring, Julie Elizabeth; Glymour, Maria Lee; Grodstein, Francine; Kurth, Tobias

    2012-01-01

    Objective: To evaluate the association between migraine and cognitive decline among women. Design Prospective cohort study. Setting Women’s Health Study, United States. Participants 6349 women aged 65 or older enrolled in the Women’s Health Study who provided information about migraine status at baseline and participated in cognitive testing during follow-up. Participants were classified into four groups: no history of migraine, migraine with aura, migraine without aura, and past history of m...

  14. Backache amongst soldiers: a prospective analytical study

    International Nuclear Information System (INIS)

    Objective: To investigate the occupational predispositions of low back pain in soldiers Study Design: Descriptive study. Place and Duration of Study: Combined Military Hospital, Bahawalpur, from June 2009 to Jan 2010. Patients and Methods: A questionnaire was developed to investigate the occupation-related issues in soldiers reporting with low backache in surgical OPD at CMH Bahawalpur. It included personal and occupational factors. The body mass index was also calculated. Of the 107 male soldiers assessed, 90 were enrolled into the study. The statistical analysis was performed by descriptive analysis of the data using SPSS 17.0. Results: Of all the soldiers evaluated (n=90), 32 (35.6%) were clerks/computer operators, 21 (23.1%) were drivers and 14(15.6%) were signal men. All were males (100%) and the average BMI was 24.8 kg/m2. The 69 (76.7%) patients who had backache had prolonged working hours (average 10.8 hours per day), 68 (75.6%) patients used to sleep over tape/nawar bed and only 12 (13.3%) had been sleeping on mattresses. The onset of pain was sudden in 58 (64.4%) patients. 27 (23.3%) had developed acute backache after prolonged sitting, 21 (30%) after lifting heavy objects. The pain was exaggerated by doing morning physical training 82 (91.1%), prolonged sitting 61 (67.8%) and standing with rifle 24 (26.7%). Conclusion: The prevalence of low back pain in sedentary occupation or soldiers on sitting jobs was higher 69 (76%). The number of working hours on these occupations was associated with occurrence as well as aggravation of low back pain. (author)

  15. The effects of an 8-week computer-based brain training programme on cognitive functioning, QoL and self-efficacy after stroke.

    Science.gov (United States)

    Wentink, M M; Berger, M A M; de Kloet, A J; Meesters, J; Band, G P H; Wolterbeek, R; Goossens, P H; Vliet Vlieland, T P M

    2016-10-01

    Cognitive impairment after stroke has a direct impact on daily functioning and quality of life (QoL) of patients and is associated with higher mortality and healthcare costs. The aim of this study was to determine the effect of a computer-based brain training programme on cognitive functioning, QoL and self-efficacy compared to a control condition in stroke patients. Stroke patients with self-perceived cognitive impairment were randomly allocated to the intervention or control group. The intervention consisted of an 8-week brain training programme (Lumosity Inc.®). The control group received general information about the brain weekly. Assessments consisted of a set of neuropsychological tests and questionnaires. In addition, adherence with trained computer tasks was recorded. No effect of the training was found on cognitive functioning, QoL or self-efficacy when compared to the control condition, except for very limited effects on working memory and speed. This study found very limited effects on neuropsychological tests that were closely related to trained computer tasks, but no transfers to other tests or self-perceived cognitive failures, QoL or self-efficacy. These findings warrant the need for further research into the value of computer-based brain training to improve cognitive functioning in the chronic phase after stroke.

  16. Effect of daily short bouts of trampoline exercise during 8 weeks on the pulmonary function and the maximal oxygen uptake of children with cystic fibrosis.

    Science.gov (United States)

    Stanghelle, J K; Hjeltnes, N; Bangstad, H J; Michalsen, H

    1988-02-01

    Six girls and two boys with cystic fibrosis (CF) 10-13.5 years of age (mean 11.5 years) participated in a prescribed exercise program on a mini-trampoline, maximum 109 min/week, during 8 weeks. The training consisted of three short bouts of trampoline exercise. The CF children were divided into two groups. The first group was a control as the other group exercised on the trampoline and vice versa. Three patients in each group completed the study. Pulmonary and exercise tests were performed before and after the exercise/control periods. The pulmonary tests (FVC, FEV1, and PEFR) showed minor changes during the exercise period, but a slight increase in FVC (P less than 0.05) during the total time of the study was found. The two patients with more advanced lung disease improved their spirometric results during the training period. The maximal oxygen uptake (VO2 max) improved from 45 to 49 ml/kg/min (P less than 0.025) during the exercise period. Trampoline exercise programs are suggested to supply other types of training to avoid monotony in the training for CF patients. PMID:3360541

  17. The effects of an 8-week computer-based brain training programme on cognitive functioning, QoL and self-efficacy after stroke.

    Science.gov (United States)

    Wentink, M M; Berger, M A M; de Kloet, A J; Meesters, J; Band, G P H; Wolterbeek, R; Goossens, P H; Vliet Vlieland, T P M

    2016-10-01

    Cognitive impairment after stroke has a direct impact on daily functioning and quality of life (QoL) of patients and is associated with higher mortality and healthcare costs. The aim of this study was to determine the effect of a computer-based brain training programme on cognitive functioning, QoL and self-efficacy compared to a control condition in stroke patients. Stroke patients with self-perceived cognitive impairment were randomly allocated to the intervention or control group. The intervention consisted of an 8-week brain training programme (Lumosity Inc.®). The control group received general information about the brain weekly. Assessments consisted of a set of neuropsychological tests and questionnaires. In addition, adherence with trained computer tasks was recorded. No effect of the training was found on cognitive functioning, QoL or self-efficacy when compared to the control condition, except for very limited effects on working memory and speed. This study found very limited effects on neuropsychological tests that were closely related to trained computer tasks, but no transfers to other tests or self-perceived cognitive failures, QoL or self-efficacy. These findings warrant the need for further research into the value of computer-based brain training to improve cognitive functioning in the chronic phase after stroke. PMID:27184585

  18. Statistical principles for prospective study protocols:

    DEFF Research Database (Denmark)

    Christensen, Robin; Langberg, Henning

    2012-01-01

    In the design of scientific studies it is essential to decide on which scientific questions one aims to answer, just as it is important to decide on the correct statistical methods to use to answer these questions. The correct use of statistical methods is crucial in all aspects of research...... (rigorous) protocol writing too troublesome, will realize that they have already written the first half of the final paper if they follow these recommendations; authors simply need to change the protocols future tense into past tense. Thus, the aim of this clinical commentary is to describe and explain...

  19. Puerperal endometritis: a prospective microbiologic study.

    Science.gov (United States)

    Gibbs, R S; O'DELL, T N; MacGregor, R R; Schwarz, R H; Morton, H

    1975-04-01

    This study was undertaken to determine the flora in the endometrial cavity of two groups of puerperal patients: 47 afebrile control subjects and 27 with endometritis. A transcervical culturing technique designed to avoid cervical contamination and to preserve aerobes, anaerobes, and mycoplasma was employed, and bacterial colony counts were reported semiquantitatively. No difference was found in the flora of these two groups. Furthermore, the most common pathogenic organisms (in decreasing order of frequency) were peptostreptococci, peptococci, Bacteroides sp., gamma-streptococci, enterococci, beta-streptococci, alpha-streptococci, and E. coli. PMID:1090177

  20. A prospective, randomized multicenter study comparing APD and CAPD treatment

    DEFF Research Database (Denmark)

    Bro, S; Bjorner, J B; Tofte-Jensen, P;

    2000-01-01

    OBJECTIVE: The goals for maintenance dialysis treatment are to improve patient survival, reduce patient morbidity, and improve patient quality of life. This is the first randomized prospective study comparing automated peritoneal dialysis (APD) and continuous ambulatory peritoneal dialysis (CAPD......) treatment with respect to quality of life and clinical outcomes in relation to therapy costs. DESIGN: A prospective, randomized multicenter study. SETTING: Three Danish CAPD units. PATIENTS: Thirty-four adequately dialyzed patients with high or high-average peritoneal transport characteristics were included...... in the study.Twenty-five patients completed the study. INTERVENTIONS: After randomization, 17 patients were allocated to APD treatment and 17 patients to CAPD treatment for a period of 6 months. Medical and biochemical parameters were evaluated at monthly controls in the CAPD units. Quality-of-life parameters...

  1. Nationwide Prospective Study of Outcomes after Elective Incisional Hernia Repair

    DEFF Research Database (Denmark)

    Helgstrand, Frederik; Rosenberg, Jacob; Kehlet, Henrik;

    2013-01-01

    BACKGROUND: Incisional hernia repair is a frequent surgical procedure, but perioperative risk factors and outcomes have not been prospectively assessed in large-scale studies. The aim of this nationwide study was to analyze surgical risk factors for early and late outcomes after incisional hernia...... in open repair were significant risk factors for poor late outcomes (p rates of readmission and reoperation for recurrence. Readmission and reoperation for recurrence were most pronounced after open repair and repair for hernia...... repair. STUDY DESIGN: We conducted a prospective nationwide study on all elective incisional hernia repairs registered in the Danish Ventral Hernia Database between January 1, 2007 and December 31, 2010. Main outcomes measures were surgical risk factors for 30-day readmission, reoperation (excluding...

  2. Remembering about Intended Actions: review of Studies on Prospective Memory.

    OpenAIRE

    Albiński, Rafał

    2009-01-01

    The aim of the article is to acquaint the reader with the subject of prospective memory, especially in its event-based form. Definition of prospective memory is presented in the text along with discussion concerning the place of prospective memory in the broadly understood memory research area. Critical features of prospective tasks and two types of processes (automatic and controlled) mediating prospective memory are described. Also presented is the multi-process framework of prospective mem...

  3. Vocal Cord Paralysis and its Etiologies: A Prospective Study

    OpenAIRE

    Seyed Javad Seyed Toutounchi; Mahmood Eydi; Samad EJ Golzari; Mohammad Reza Ghaffari; Nashmil Parvizian

    2014-01-01

    Introduction: Vocal cord paralysis is a common symptom of numerous diseases and it may be due to neurogenic or mechanical fixation of the cords. Paralysis of the vocal cords is just a symptom of underlying disease in some cases; so, clinical diagnosis of the underlying cause leading to paralysis of the vocal cords is important. This study evaluates the causes of vocal cord paralysis. Methods: In a prospective study, 45 patients with paralyzed vocal cord diagnosis were examined by tests such a...

  4. Urodynamic parameters and plasma LH/FSH in spayed Beagle bitches before and 8 weeks after GnRH depot analogue treatment.

    Science.gov (United States)

    Reichler, Iris Margaret; Barth, Andrea; Piché, Claude A; Jöchle, Wolfgang; Roos, Malgorzata; Hubler, Madeleine; Arnold, Susi

    2006-12-01

    The pathophysiology of urinary incontinence due to spaying remains unknown. Incontinent bitches can be treated successfully with depot preparations of GnRH-analogues and there are differences in plasma gonadotropin levels between continent and incontinent spayed bitches. It is therefore assumed that the supraordinated hormones, GnRH, FSH, and/or LH, have an effect on the urodynamic parameters. In this study, the potential influence of these hormones on the lower urinary tract was investigated by measuring urethral pressure profiles and cystometry. Simultaneously, plasma concentrations in 10 spayed Beagle bitches were determined 5 weeks prior to and 8 weeks after treatment with the GnRH analogue leuprolide. Within 1 week of GnRH analogue administration, plasma FSH and LH levels decreased from 72.5 and 7.7 to 7.75 and 0.72ng/mL, respectively. These plasma gonadotropin levels correspond with those of intact bitches during anoestrus. Urethral pressure profiles indicated that the treatment had no significant effect on maximum urethral closure pressure, functional and total length of the urethra, or area of the closure pressure curve. The data obtained by cystometry regarding mean bladder threshold volume showed a significant increase from 109 to 172mL. The improvement in bladder function after the application of GnRH-application is presumably a direct effect of the GnRH as a relationship between the plasma gonadotropin levels and the urodynamic parameters could not demonstrated. PMID:16876857

  5. The effects of 8 weeks of motor skill training on cardiorespiratory fitness and endurance performance in children with developmental coordination disorder.

    Science.gov (United States)

    Farhat, Faiçal; Masmoudi, Kaouthar; Hsairi, Ines; Smits-Engelsman, Bouwien C M; Mchirgui, Radhouane; Triki, Chahnez; Moalla, Wassim

    2015-12-01

    Interventions based on everyday motor skills have been developed to be effective in children with developmental coordination disorder (DCD). The purpose of the present study was to examine the effects of motor skill training on exercise tolerance and cardiorespiratory fitness in children with DCD. Children were assigned to 3 groups: an experimental training group comprising 14 children with DCD, a control nontraining group comprising 13 children with DCD, and a control nontraining group comprising 14 typically developed children. All participants were tested twice with an interval of 8-weeks on a cardiopulmonary exercise test, pulmonary function testing, and a 6-min walk test. After the training program the maximal power output was significantly increased for DCD group at anaerobic threshold (p Children with DCD that participated in the training program improved their walking distance (t (13) = -9.08, p developed group did not change on any of the measures. In conclusion, training delayed reaching the anaerobic threshold and improved aerobic endurance and exercise tolerance in children with DCD.

  6. Pros and cons of a wandering mind: a prospective study

    OpenAIRE

    Ottaviani, Cristina; Couyoumdjian, Alessandro

    2013-01-01

    Mind wandering (MW) has recently been associated with both adaptive (e.g., creativity enhancement) and maladaptive (e.g., mood worsening) consequences. This study aimed at investigating whether proneness to MW was prospectively associated with negative health outcomes. At time 0, 21 women, 19 men; mean age = 24.5 (4.9) underwent a 5-min baseline electrocardiogram (ECG), a 20-min laboratory tracking task with thought probes, and personality questionnaires. At time 1 (1 year follow-up), the sam...

  7. Risk of Complications in Spine Surgery: A Prospective Study

    OpenAIRE

    Reis, Rodolfo Casimiro; de Oliveira, Matheus Fernandes; Rotta, José Marcus; Botelho, Ricardo Vieira

    2015-01-01

    Purpose : Complications are the chief concern of patients and physicians when considering spine surgery. The authors seek to assess the incidence of complications in patients undergoing spine surgery and identify risk factors for their occurrence. Methods : Prospective study of patients undergoing spine surgery from 1 February 2013 to 1 February 2014. Epidemiological characteristics and complications during the surgical hospitalization were recorded and analyzed. Results : The sample comprise...

  8. Predictors of Remission From Body Dysmorphic Disorder: A Prospective Study

    OpenAIRE

    Phillips, Katharine A.; Pagano, Maria E.; Menard, William; Fay, Christina; Stout, Robert L.

    2005-01-01

    In the first naturalistic, prospective study of the course of body dysmorphic disorder (BDD), we examined predictors of remission in 161 subjects over 1 year of follow-up. Data were obtained on clinical characteristics at the intake interview and weekly BDD symptom severity over 1 year using the Longitudinal Interval Follow-Up Evaluation. More severe BDD at intake, longer BDD duration, and the presence of a comorbid personality disorder predicted a lower likelihood of partial or full remissio...

  9. Why qualified prospects decline timeshare sales presentations: a qualitative study

    OpenAIRE

    Johannsen, Ana Mafalda Gonçalves

    2013-01-01

    Mestrado em Gestão Hoteleira e Turismo/ JEL codes: L83; M31 This dissertation is a qualitative study about why qualified prospects decline timeshare sales presentation even though they earn a small incentive for doing so. The Hoffman and Bateson’s decision process model is used as a broad theoretical framework. On this basis and the inputs of managers and off-premise contact (OPC) representatives of a Marketing company located in Orlando, Florida, USA, five main lik...

  10. Evaluation of erectile function after urethral reconstruction: a prospective study

    OpenAIRE

    Xie, Hong; Xu, Yue-Min; XU Xiao-lin; Sa, Yin-Long; Wu, Deng-Long; Zhang, Xin-Chi

    2009-01-01

    We conducted a prospective study of erectile dysfunction (ED) after urethral reconstructive surgery, using the 5-item International Index of Erectile Function (IIEF-5), the Sexual Life Quality Questionnaire (SLQQ) and the Quality of Life Questionnaire (QoLQ). Between January 2003 and July 2007, 125 male patients with urethral strictures underwent urethroplasty, and pre- and post-surgery erectile function was assessed using these three questionnaires. A formula to predict the probability of ED...

  11. On Prospective Technology Studies. (KIT Scientific Reports ; 7599)

    OpenAIRE

    Banse, Gerhard; Grunwald, Armin; Hronszky, Imre; Nelson, Gordon [Hrsg.

    2011-01-01

    This volume includes papers to technological foresight, roadmapping and TA from two sources. On the one side it is based on a workshop in Budapest at the end of 2007, that was organized in the framework of the International Forum on Sustainable Technological Development. On the other side selected presentations from the symposium on History of Prospective Technology Studies, in the framework of the XXIII International Congress of History of Science and Technology, Budapest, July 2009.

  12. Surgical site infections in Italian Hospitals: a prospective multicenter study

    OpenAIRE

    Ippolito Giuseppe; Martini Lorena; Nicastri Emanuele; Drapeau Cecilia MJ; Petrosillo Nicola; Moro Maria

    2008-01-01

    Abstract Background Surgical site infections (SSI) remain a major clinical problem in terms of morbidity, mortality, and hospital costs. Nearly 60% of SSI diagnosis occur in the postdischarge period. However, literature provides little information on risk factors associated to in-hospital and postdischarge SSI occurrence. A national prospective multicenter study was conducted with the aim of assessing the incidence of both in-hospital and postdisharge SSI, and the associated risk factors. Met...

  13. Liver elasticity measurement before and after biliary drainage in patients with obstructive jaundice: a prospective cohort studya prospective cohort study

    OpenAIRE

    Kubo, Kimitoshi; Kawakami, Hiroshi; Kuwatani, Masaki; Nishida, Mutsumi; Kawakubo, Kazumichi; Kawahata, Shuhei; Taya, Yoko; Kubota, Yoshimasa; Amano, Toraji; Shirato, Hiroki; Sakamoto, Naoya

    2016-01-01

    Background Obstructive jaundice has been reported to influence liver elasticity, independent of liver fibrosis. The aim of our prospective study was to evaluate the changes in liver elasticity, before and after biliary drainage, in patients with obstructive jaundice, and to evaluate the correlation between elasticity measures and serum markers of liver fibrosis. Methods This is a prospective cohort study of 20 patients with obstructive jaundice. Liver elasticity was assessed by Transient Elas...

  14. Prospective economical study of the nuclear power file; Etude economique prospective de la filiere electrique nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Charpin, J.M. [Commissariat General du Plan, 75 - Paris (France); Dessus, B. [Ecodev-CNRS, 92 - Meudon (France); Pellat, R. [CEA, 75 - Paris (France)

    2000-07-01

    On May 7, 1999 an economical study of the overall nuclear file, and in particular, of the back-end part of the fuel cycle and including the reprocessing, was requested by the French Prime Minister. This study includes the cost comparisons with the other means of power production and takes into consideration the environmental costs. The study is shared into five chapters dealing with: 1 - the legacy of the past: todays park of nuclear plants, economical and material status; 2 - the international evolution: the dynamics of nuclear policies worldwide (existing parks and R and D programs), the rise of environmental problems worldwide (CO{sub 2} and the climate convention, nuclear risks, attempts of including environment in the power costs), the choices made for the management of spent fuels in the main countries; 3 - the technological prospects for the power production and use: technologies for the mastery of power demand (residential, industrial and tertiary sectors, power transportation), technologies of power production (production from nuclear, fossil and renewable energies); 4 - prospective scenarios for France: two demand scenarios at the year 2050 vista (energy, electric power), power supply (supply structure with respect to scenarios, nuclear parks, power capacities), environmental aspects (CO{sub 2} emissions, plutonium and minor actinides production); 5 - the economical status of the different scenarios: data preparation, fossil fuel price scenarios, investment and operation costs of the different power production means (nuclear, fossil and renewable energies, natural gas and power distribution networks), comparison between fluxes and cumulated economic costs linked with the different scenarios (investments, exploitation, fuels, R and D, status for 2000 to 2050), time structure of expenditures with respect to the different scenarios (chronology, statuses, kWh costs, sensitivity with respect to the rate of discount, valorization of existing parks in 2050

  15. Effect of Micronutrients on Behavior and Mood in Adults with ADHD: Evidence from an 8-Week Open Label Trial with Natural Extension

    Science.gov (United States)

    Rucklidge, Julia; Taylor, Mairin; Whitehead, Kathryn

    2011-01-01

    Objective: To investigate the effect of a 36-ingredient micronutrient formula consisting mainly of minerals and vitamins in the treatment of adults with both ADHD and severe mood dysregulation (SMD). Method: 14 medication-free adults (9 men, 5 women; 18-55 years) with ADHD and SMD completed an 8-week open-label trial. Results: A minority reported…

  16. Future prospects for studies in the VUV-SX region

    International Nuclear Information System (INIS)

    This book carries papers presented at a workshop 'Future Prospects for Studies in the VUV-SX Region' held on March 22 and 23, 1989. The workshop focussed particularly on the promotion of research in the VUV and soft X-ray regions. Three sessions were held: Session 1 for studies in peripheral areas, Session 2 for theoretical studies, and Session 3 for recent developments. Session 1 covered five studies: 'Laser Spectroscopy: High-Resolution Observation of Highly Electronically Excited Gaseous Molecule', 'High-Resolution Electron Spectroscopy: Surface Phonon Spectroscopy', 'Experimental Study on Atoms and Molecules through Ion Trap', 'Basic Mechanism of Photo-Induced CVD', and 'Application of Circularly Polarized Light'. Session 2 covered five studies: 'Electronic State of High Tc Superconducting Oxide', 'Surface Condition and Electronic State', 'XES and XAS Study of Rare Earth Compound', 'Resonance Photoelectric Spectroscopy on Strongly Correlated Electronic System', and 'Circularly Polarized Light and Atomic Process in Soft X-Ray Region'. Session 3 covered six studies: 'Prospects of Application of Supercritical Liquid to Research on Physical Characteristics', 'Application of Orbit Radiation to Polarization Spectroscopy', 'XES Research for La Compounds', 'Characteristics of Ultra-Fine Particles', 'Surface Study by Angular-Resolution Photoelectric Spectroscopy', and 'EXAFS Study of Light Element'. (N.K.)

  17. The 5- or 10-km Marikenloop Run: A Prospective Study of the Etiology of Running-Related Injuries in Women.

    Science.gov (United States)

    van der Worp, Maarten P; de Wijer, Anton; van Cingel, Robert; Verbeek, André L M; Nijhuis-van der Sanden, Maria W G; Staal, J Bart

    2016-06-01

    Study Design Prospective cohort. Background The popularity of running events is still growing, particularly among women; however, little is known about the risk factors for running-related injuries in female runners. Objectives The aims of this study were to determine the incidence and characteristics (site and recurrence) of running-related injuries and to identify specific risk factors for running-related injuries among female runners training for a 5- or 10-km race. Methods Four hundred thirty-five women registered for the Marikenloop run of 5 or 10 km were recruited. Follow-up data were collected over 12 weeks using questionnaires, starting 8 weeks before the event and ending 4 weeks after the event. Two orthopaedic tests (navicular drop test and extension of the first metatarsophalangeal joint) were performed in the 8 weeks before the event. Running-related injuries, defined as running-related pain of the lower back and/or the lower extremity that restricted running for at least 1 day, were assessed at 1-, 2-, and 3-month follow-ups. Results Of 417 female runners with follow-up data (96%), 93 runners (22.3%) reported 109 running-related injuries, mainly of the hip/groin, knee, and lower leg. Multivariable Cox regression analysis showed that a weekly training distance of more than 30 km (hazard ratio = 3.28; 95% confidence interval [CI]: 1.23, 8.75) and a previous running injury longer than 12 months prior (hazard ratio = 1.88; 95% CI: 1.03, 3.45) were associated with the occurrence of running-related injuries. Conclusion Hip/groin, knee, and lower-leg injuries were common among female runners. Only weekly training distance (greater than 30 km) and previous running injury (greater than 12 months prior) were associated with running-related injuries in female runners training for a 5- or 10-km event. Level of Evidence Etiology, 2b. J Orthop Sports Phys Ther 2016;46(6):462-470. Epub 26 Apr 2016. doi:10.2519/jospt.2016.6402. PMID:27117730

  18. Primary stapedotomy in children with otosclerosis : A prospective study of 41 consecutive cases

    NARCIS (Netherlands)

    Vincent, Robert; Wegner, Inge; Vonck, Bernard M D; Bittermann, Arnold J; Kamalski, Digna M A; Grolman, Wilko

    2016-01-01

    OBJECTIVES/HYPOTHESIS: To prospectively evaluate hearing outcomes in children with otosclerosis undergoing primary stapes surgery. STUDY DESIGN: A nonrandomized, nonblinded, prospective case series. METHODS: Thirty-four consecutive pediatric patients who underwent 41 primary stapedotomies for otoscl

  19. Role of different childbirth strategies on pelvic organ prolapse and stress urinary incontinence: a prospective study

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Background Traumatic damage to fascial and muscular support structures during childbirth may be a major factor of the development of stress urinary incontinence (SUI) and pelvic organ prolapse (POP).The aim of this study was to prospectively investigate the role of different childbirth strategies on POP and SUI.Methods A total of 120 selected pregnant women were recruited and divided into two groups:vaginal delivery group (n=72)and selective cesarean delivery group(n=48).The women were questioned with SUI sheet and estimated with POP quantification (POP-Q) within 6-8 weeks after delivery.The correlations of SUI and results of POP-Q with the strategies of delivery were analyzed.ttest,X2 test,and the Mann-Witney test were used for statistical analysis.Results Among the 120 women,SUI was developed during 29-30 gestational weeks in 20 patients (16.6%),of whom 14 (70%) had symptoms of SUI till 6 weeks postpartum. Totally 20 (16.6%) women had SUI symptoms after delivery.The prevalence of postpartum SUI was positively correlated with the occurrence of SUI during 29-30 gestational weeks (P<0.001).In the vaginal delivery group,100% of the women suffered form urinary prolapse 6 weeks postpartum,while 87.5% of those in the selective cesarean delivery group developed POP (P<0.01). The percentages of the first-and second-degree urinary prolapse in the vaginal delivery group were 20.8% and 79.2% respectively,which were significantly different from those in the selective cesarean delivery group (64.6% and 22.9%;both P=0.000).Conclusions Pregnancy and delivery play an etiologic role in the development of SUI and POP. The onset of SUI during late pregnancy implies a significant risk of postpartum SUI symptoms.The prevalence of POP is significantly higher after vaginal delivery than after cesarean delivery.

  20. A prospective study of urinary tract infection during pelvic radiotherapy

    International Nuclear Information System (INIS)

    The frequency of urinary tract infection before and during pelvic radiotherapy was studied prospectively in 172 patients who were not catherised and had not had instrumentation for at least 4 weeks prior to radiotherapy. The incidence of urinary tract infection prior to radiotherapy was 17% and a further 17% of patients develped a urinary tract infection during radiotherapy. Mid-stream specimens of urine (MSU) should be examined for infection on a weekly basis during pelvic radiotherapy not only to identify this additional 17% of patients but also to detect those patients who have persistent urinary tract infection in spite of treatment with appropriate antibiotics. (author). 6 refs.; 1 fig.; 4 tabs

  1. Psychological stress during pregnancy and stillbirth: prospective study

    DEFF Research Database (Denmark)

    Wisborg, K.; Barklin, A.; Hedegaard, M.;

    2008-01-01

    OBJECTIVE: To study the association between psychological stress during pregnancy and stillbirth. DESIGN: Prospective follow-up study. SETTING: Aarhus University Hospital, Skejby, Denmark,1989-98. POPULATION: A total of 19 282 singleton pregnancies in women with valid information about psychologi......OBJECTIVE: To study the association between psychological stress during pregnancy and stillbirth. DESIGN: Prospective follow-up study. SETTING: Aarhus University Hospital, Skejby, Denmark,1989-98. POPULATION: A total of 19 282 singleton pregnancies in women with valid information about...... psychological stress during pregnancy. METHODS: Information about psychological stress during pregnancy was obtained from questionnaires and measured by the 12-item General Health Questionnaires (GHQ). A score was generated by the sum of all the answers, each contributing a value between 0 (low psychological...... stress) and 3 (high psychological stress). Women with an intermediate level of psychological stress (scores of 7-11) were considered the reference group. Scores of 0-6 were defined as a low level of psychological stress and scores of 12-36 as the highest level. The association between psychological...

  2. Manipulation Therapy Relieved Pain More Rapidly Than Acupuncture among Lateral Epicondylalgia (Tennis Elbow Patients: A Randomized Controlled Trial with 8-Week Follow-Up

    Directory of Open Access Journals (Sweden)

    Chung-Yuan Hsu

    2016-01-01

    Full Text Available Radial bone adjustment manipulation treatment may be effective to reduce pain rapidly in lateral epicondylalgia patients and the pathological tension in the biceps brachii muscle is highly concerned. To prove this hypothesis, we conducted a randomized controlled trial and included 35 patients with lateral epicondylalgia for more than 2 months. Either manipulation treatment (n=16 or acupuncture (n=19 was given to these patients for 2 weeks and all patients’ symptoms were followed up for 8 weeks after treatment. Both groups demonstrated changes in pain VAS score, grip strength, and DASH questionnaire. Lateral epicondylalgia patients who received manipulation treatment felt pain relief sooner than those who had acupuncture treatments during the first few treatments. However, both acupuncture and manipulation are effective, while the difference has no significance at the 8-week follow-up. The trial was registered with Current Controlled Trials ISRCTN81308551 on 5 February 2016.

  3. Manipulation Therapy Relieved Pain More Rapidly Than Acupuncture among Lateral Epicondylalgia (Tennis Elbow) Patients: A Randomized Controlled Trial with 8-Week Follow-Up.

    Science.gov (United States)

    Hsu, Chung-Yuan; Lee, Ko-Hung; Huang, Hsin-Chia; Chang, Zi-Yu; Chen, Hsing-Yu; Yang, Tsung-Hsien

    2016-01-01

    Radial bone adjustment manipulation treatment may be effective to reduce pain rapidly in lateral epicondylalgia patients and the pathological tension in the biceps brachii muscle is highly concerned. To prove this hypothesis, we conducted a randomized controlled trial and included 35 patients with lateral epicondylalgia for more than 2 months. Either manipulation treatment (n = 16) or acupuncture (n = 19) was given to these patients for 2 weeks and all patients' symptoms were followed up for 8 weeks after treatment. Both groups demonstrated changes in pain VAS score, grip strength, and DASH questionnaire. Lateral epicondylalgia patients who received manipulation treatment felt pain relief sooner than those who had acupuncture treatments during the first few treatments. However, both acupuncture and manipulation are effective, while the difference has no significance at the 8-week follow-up. The trial was registered with Current Controlled Trials ISRCTN81308551 on 5 February 2016. PMID:27143983

  4. Community Water Fluoridation and Intelligence: Prospective Study in New Zealand.

    Science.gov (United States)

    Broadbent, Jonathan M; Thomson, W Murray; Ramrakha, Sandhya; Moffitt, Terrie E; Zeng, Jiaxu; Foster Page, Lyndie A; Poulton, Richie

    2015-01-01

    Objectives. This study aimed to clarify the relationship between community water fluoridation (CWF) and IQ. Methods. We conducted a prospective study of a general population sample of those born in Dunedin, New Zealand, between April 1, 1972, and March 30, 1973 (95.4% retention of cohort after 38 years of prospective follow-up). Residence in a CWF area, use of fluoride dentifrice and intake of 0.5-milligram fluoride tablets were assessed in early life (prior to age 5 years); we assessed IQ repeatedly between ages 7 to 13 years and at age 38 years. Results. No clear differences in IQ because of fluoride exposure were noted. These findings held after adjusting for potential confounding variables, including sex, socioeconomic status, breastfeeding, and birth weight (as well as educational attainment for adult IQ outcomes). Conclusions. These findings do not support the assertion that fluoride in the context of CWF programs is neurotoxic. Associations between very high fluoride exposure and low IQ reported in previous studies may have been affected by confounding, particularly by urban or rural status.

  5. Effects of an 8-Week Outdoor Brisk Walking Program on Fatigue in Hi-Tech Industry Employees: A Randomized Control Trial.

    Science.gov (United States)

    Wu, Li-Ling; Wang, Kuo-Ming; Liao, Po-I; Kao, Yu-Hsiu; Huang, Yi-Ching

    2015-10-01

    Over 73% of hi-tech industry employees in Taiwan lack regular exercise. They are exposed to a highly variable and stressful work environment for extended periods of time, and may subsequently experience depression, detrimental to workers' physiological and mental health. In this cross-sectional survey, the authors explored the effect of an 8-week brisk walking program on the fatigue of employees in the hi-tech industry. The participants, from a hi-tech company in northern Taiwan, were randomly assigned to an experimental group (EG; 41 subjects, Mage = 33.34 ± 6.40) or control group (CG; 45 subjects, Mage = 29.40 ± 3.60). Following the 8-week brisk walking program, the EG showed significantly lower scores for subjective fatigue, working motivation, attention, and overall fatigue. The authors confirmed that the 8-week outdoor brisk walking program significantly improved the level of fatigue among employees of the hi-tech industry. The finding serves as an important reference for health authorities in Taiwan and provides awareness of workplace health promotion in the hi-tech industry. PMID:26194655

  6. Cohort Profile: Golestan Hepatitis B Cohort Study- A Prospective Long Term Study in Northern Iran ​

    OpenAIRE

    Poustchi, Hossein; Katoonizadeh, Aezam; Ostovaneh, Mohammad Reza; Moossavi, Shirin; Sharafkhah, Maryam; Esmaili, Saeed; Pourshams, Akram; Mohamadkhani, Ashraf; Besharat, Sima; Merat, Shahin; Mohamadnejad, Mehdi; George, Jacob; Malekzadeh, Reza

    2014-01-01

    Hepatitis B virus (HBV) infection is the most common cause of end stage liver disease in Iran and in Golestan province. Large-scale population-based prospective cohort studies with long term follow-up are the method of choice to accurately understand the natural course of HBV infection. To date, several studies of HBV epidemiology, natural history, progression to cirrhosis and association with HCC have been reported from other countries. However, few of these are prospective and fewer still a...

  7. Prospect Theory: A Study of the Endowment Effect

    Directory of Open Access Journals (Sweden)

    Jurandir Sell Macedo

    2007-01-01

    Full Text Available Behavioral Finance is a recent field of study which contradicts the presupposition supported by Modern Finance that decision makers act rationally. Prospect Theory, developed by Kahneman and Tversky (1979, is presented as an alternative model to the Theory of Expected Utility in relation to the way people decide in face of possibilities of risk. According to Prospect Theory, people define gains and losses based on a given point of reference, which can be established on grounds of a given level of expected gain. This fact leads to the Endowment Effect - a behavioral trend investigated in this study – whereby investors are influenced by a portfolio which they have received as an inheritance or endowment. The reason this occurs is that individuals usually define their expectations of gain according to the future profitability of the portfolio received, and not according to the future profitability of the market. Using an investment simulation, the Endowment Effect was tested among 226 university students taking courses in the subject of capital markets. The results demonstrate that the students were influenced by the different initial portfolios, which were randomly assigned.

  8. A Prospective Study of Nonsuppurative Complications of Streptococcal Pharyngitis

    Directory of Open Access Journals (Sweden)

    Mesut Yılmaz

    2016-03-01

    Full Text Available Objective: Group A Streptococci (GAS are the most important bacterial cause of pharyngitis. Antibiotic therapy can be prescribed and failure to treat it is associated with suppurative and nonsuppurative complications. Nonsuppurative complications occur after a latency period of a few weeks and include acute rheumatic fever, scarlet fever, streptococcal toxic shock syndrome, acute glomerulonephritis, and pediatric autoimmune neuropsychiatric disorder associated with group A streptococci. The aim of this study is to investigate the frequency of nonsuppurative complications in properly treated children with GAS pharyngitis. Methods: We investigated the frequency of nonsuppurative complications in 1030 proven GAS pharyngitis patients between 5 and 15 years old, who were properly treated by a prospective observational study. All patients diagnosed with GAS pharyngitis were followed up prospectively using a standard form for six months made by monthly phone calls. Results: All the isolates recovered from the patients were susceptible to penicillin. Twentyseven (2.6% patients developed scarlet fever. No other nonsuppurative complications occured in our patient cohort. Conclusions: Penicillin remains the drug of choice for treatment of GAS pharyngitis. The rate of nonsuppurative complications of GAS pharyngitis has decreased significantly in the antibiotic era. J Microbiol Infect Dis 2016;6(1: 8-11

  9. A prospective study of pharyngocutaneous fistulas following total laryngectomy

    Directory of Open Access Journals (Sweden)

    Qureshi S

    2005-01-01

    Full Text Available Pharyngocutaneous (PC fistula is a common complication following laryngectomy. It leads to increased morbidity, delay in adjuvant treatment, prolonged hospitalization and an increase in treatment costs. Although a number of factors that result in PC fistula have been described, there is still no agreement on the most significant factors. We undertook a prospective study to critically analyze PC fistula and its association with various tumors, patient and treatment related factors. This was a prospective study that included 143 patients who underwent laryngeal surgery for squamous cell carcinoma of the larynx and pyriform sinus. Use of pectoralis major myocutaneous flap to reconstruct the neopharynx, primary disease in pyriform and extensive soft tissue infiltration were significantly associated with PC fistula. Prior treatment (radiotherapy and chemotherapy, type of closure (T closure, Y closure and vertical closure, Layers of closure (full thickness interrupted, submucosal interrupted, submucosal continuous type of suture material (silk, vicryl , age, sex, stage, preoperative tracheostomy, cut margin status, pre/postoperative hemoglobin and experience of surgeons did not relate significantly.

  10. A prospective study of spontaneous abortion: relation to amount and source of drinking water consumed in early pregnancy.

    Science.gov (United States)

    Swan, S H; Waller, K; Hopkins, B; Windham, G; Fenster, L; Schaefer, C; Neutra, R R

    1998-03-01

    In 1992, we published four retrospective studies, conducted primarily within a single California county, which found higher spontaneous abortion rates among women who drank more tapwater than bottled water in early pregnancy. The current prospective study extends that investigation to other water systems. Pregnant women from three regions in California were interviewed during their first trimester. Multivariate analyses modeled the amount and type of water consumed at 8 weeks' gestation in each region in relation to spontaneous abortion rate. In Region I, which was within the previous study area, the adjusted odds ratio (OR) comparing high (> or = 6 glasses per day) consumption of cold tapwater with none was 2.17 [95% confidence interval (CI) = 1.22-3.87]. Furthermore, when women with high cold tapwater and no bottled water consumption were compared with those with high bottled water and no cold tapwater consumption, the adjusted odds ratio was 4.58 (95% CI = 1.97-10.64). Conversely, women with high bottled water consumption and no tapwater had a reduced rate of spontaneous abortion compared with those drinking tapwater and no bottled water (adjusted OR = 0.22; 95% CI = 0.09-0.51). Neither tap nor bottled water consumption altered the risk of spontaneous abortion in Regions II and III. Although controlling for age, prior spontaneous abortion, race, gestational age at interview, and weight somewhat strengthened the association in Region I, the distribution of these confounders did not vary appreciably across regions. This study confirms the association between cold tapwater and spontaneous abortion first seen in this county in 1980. If causal, the agent(s) is not ubiquitous but is likely to have been present in Region I for some time. PMID:9504279

  11. Temporary loop ileostomy: prospective study of indications and complication

    International Nuclear Information System (INIS)

    To asses the indications and complications of temporary loop ileostomy. This was a prospective cohort study conducted at Isra University Hospital, Hyderabad, Pakistan between February 2003 and August 2006. All patients who had temporary loop ileostomy during that period were included in this study. The indications and various postoperative complications were noted during postoperative hospital stay and subsequently during follow up till stoma were closed. Fifty six patients fulfilled the selection criteria during the study period. Typhoid (enteric) perforation was the most common indication of loop ileostomy accounting for about two thirds of all cases. Other indications were iatrogenic, covering ileostomy for rectal cancers, following resection anastomosis, tuberculosis, blunt abdominal trauma, anastomosis leak and rectovaginal fistula. Post operative skin excoriation was the most common complication while poor siting, transient edema, retraction and high output were other less common complications. Temporary loop ileostomy is the stoma of choice for temporary faecal diversion as most of its complications are manageable conservatively. (author)

  12. Isoleucine and valine supplementation of crude protein-reduced diets for pigs aged 5-8 weeks

    DEFF Research Database (Denmark)

    Nørgaard, Jan Værum; Fernández, José Adalberto

    2009-01-01

    The present experiment had two purposes: (i) to study crystalline amino acid supplementation to crude protein-reduced diets, and (ii) to study the effect of different isoleucine (Ile) to lysine (Lys) and valine (Val) to Lys ratios in diets for young pigs. A total of 145 pigs were weaned at 28 days...

  13. A prospective study of occupation and prostate cancer risk.

    Science.gov (United States)

    Zeegers, Maurice P A; Friesema, Ingrid H M; Goldbohm, R Alexandra; van den Brandt, Piet A

    2004-03-01

    A wide variety of occupations has been associated with prostate cancer in previous retrospective studies. Most attention has been paid to farming, metal working, and the rubber industry. Today, these results cannot be affirmed with confidence, because many associations could be influenced by recall bias, have been inconsistent, or have not been confirmed satisfactory in subsequent studies. This study was conducted to investigate and confirm these important associations in a large prospective cohort study. The authors conducted a prospective cohort study among 58,279 men. In September 1986, the cohort members (55-69 years) completed a self-administered questionnaire on potential cancer risk factors, including job history. Related job codes were clustered in professional groups. These predefined clusters were investigated in 3 time windows: 1) profession ever performed, 2) longest profession ever held, and 3) last profession held at baseline. Follow up for incident prostate cancer was established by linkage to cancer registries until December 1993. A case-cohort approach was used based on 830 cases and 1525 subcohort members. To minimize false-positive results, 99% confidence intervals (99% CI) were calculated. Although moderately decreased prostate cancer risks were found for electricians, farmers, firefighters, woodworkers, textile workers, butchers, salesmen, teachers, and clerical workers, none of the relative risks (RR) were found to be statistically significant. For road transporters, metal workers, and managers, no association with prostate cancer risk was found. Although the RR for railway workers, mechanics, welders, chemists, painters, and cooks was moderately increased, these estimates were not statistically significant. For men who reported to have ever worked in the rubber industry, we found a substantially increased prostate cancer risk, but not statistically significant (RR, 4.18; 99% CI = 0.22-80.45). For policemen, we found a substantial and

  14. Premorbid personality in schizophrenia spectrum: a prospective study

    DEFF Research Database (Denmark)

    Ekstrøm, Morten; Lykke Mortensen, Erik; Sørensen, Holger J;

    2006-01-01

    to these three diagnostic categories. Twelve-year-old children destined to develop a disorder in the schizophrenia spectrum deviated significantly from healthy controls on a number of personality characteristics: they were rated significantly lower than controls on intelligence, concentration, maturity......, friendliness, cooperation, self-control and significantly higher on aggression. Non-significant trends indicated that this group displayed more deviant personality scores than psychiatric controls. Children who later develop schizophrenia spectrum disorder differed from normal controls with respect to a number......Schizophrenia has been linked with premorbid character anomalies since it was first described. However, few prospective studies of premorbid personality characteristics in schizophrenia and related disorders have been conducted. This study evaluates premorbid personality in children who developed...

  15. Prospective Clinical Study of Precision Oncology in Solid Tumors.

    Science.gov (United States)

    Sohal, Davendra P S; Rini, Brian I; Khorana, Alok A; Dreicer, Robert; Abraham, Jame; Procop, Gary W; Saunthararajah, Yogen; Pennell, Nathan A; Stevenson, James P; Pelley, Robert; Estfan, Bassam; Shepard, Dale; Funchain, Pauline; Elson, Paul; Adelstein, David J; Bolwell, Brian J

    2016-03-01

    Systematic studies evaluating clinical benefit of tumor genomic profiling are lacking. We conducted a prospective study in 250 patients with select solid tumors at the Cleveland Clinic. Eligibility required histopathologic diagnosis, age of 18 years or older, Eastern Cooperative Oncology Group performance status 0-2, and written informed consent. Tumors were sequenced using FoundationOne (Cambridge, MA). Results were reviewed at the Cleveland Clinic Genomics Tumor Board. Outcomes included feasibility and clinical impact. Colorectal (25%), breast (18%), lung (13%), and pancreatobiliary (13%) cancers were the most common diagnoses. Median time from consent to result was 25 days (range = 3-140). Of 223 evaluable samples, 49% (n = 109) of patients were recommended a specific therapy, but only 11% (n = 24) received such therapy: 12 on clinical trials, nine off-label, three on-label. Lack of clinical trial access (n = 49) and clinical deterioration (n = 29) were the most common reasons for nonrecommendation/nonreceipt of genomics-driven therapy.

  16. OPERATIVE TR EATMENT OF CLAVICULAR FRACTURES: A PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Timma Reddy

    2015-09-01

    Full Text Available BACKGROUND: Fractures of clavicle constitute one of the commonest fractures in orthopaedic practice and till recently most of these fractures were treated conservatively. The advent of various implants for the fixation of these fractures along with safe surgical practices made the surgery more widely accepted and the definite indications for open reduction and internal fixation were formulated. MATERIAL & METHODS: In this prospective study, conducted in the department of orthopedics and Traumatology of Osmania General Hospital, Hyderabad, 4o patients who were operated for fracture clavicle were included. The study period was from September 2012 to September 2014. CONCLUSIONS : Operative treatment of fractu re clavicle offers a definitive method of treatment in some specific instances. It reduces the time of union, stiffness of the adjoining joints and morbidity.

  17. A prospective clinical study of patients with hypernatraemic dehydration.

    Science.gov (United States)

    Eke, F; Nte, A

    1996-09-01

    In a clinical prospective 3-year study of 158 children aged 2 weeks to 14 years with hypernatraemic dehydration (serum sodium 150 mmol/l or more), infants predominated (61.4%). The 158 children with hypernatraemia accounted for 13.7% of all children admitted with gastroenteritis over the same period, and significant aetiological factors included the use of artificial feeds, differences between the children with hypernatraemia and those with normo- or hyponatraemia, P dehydration P dehydrated. There was also a significant difference between the presence of neurological features in hyper- and normonatraemic patients P Hypernatraemic dehydration remains an important and serious complication of childhood gastroenteritis in our area of study. The use of artificial milk feeds is contributory, and well-nourished babies appear more at risk. We recommend more liberal water intake during gastroenteritis and the public should also be educated on and made more aware of this condition.

  18. progress and prospects for studies on chinese amphibians

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    this work summarizes the history and progress of the studies on chinese amphibians since they first appeared in the chinese literature.a wide range of research has been carried out,including the history of the definition of amphibians,faunal surveys,systematic research,ecological research,biochemical research (isozyme and other proteins or peptides,chromosomes,dna),anatomical research,embryological research,phylogenetic and zoogeographical research,and many others such as ultrastructure of organs,crossbreeding test,regeneration of organs,abnormality survey,acoustics,fossils,sperm ultrastructure and parasites.in addition,the prospects for studies on chinese amphibians in future are proposed in this paper.

  19. Study of Tandem Accelerator Technology and Its Prospects

    International Nuclear Information System (INIS)

    Tandem accelerator is an ion acceleration tool in which negative ions injected in the accelerator tube and stripped to become positive ions, then accelerated by electrostatic high voltage such that its energy is multiplied. In this paper, we describe the prospect of accelerator application briefly in agriculture and biotechnology, industry, health and medicine, environment fields. Technical study on tandem accelerator included SNICS and alphatross ion sources, acceleration system and stripper system. The study result for many kinds of negative ions and its current which should be injected in the accelerator tube and the output of tandem accelerator H+, and the distribution of C+, Ni+, Au+, Br+ ion on varying charge state is shown. (author)

  20. The Copenhagen Prospective Study on Asthma in Childhood (COPSAC)

    DEFF Research Database (Denmark)

    Bisgaard, Hans

    2004-01-01

    BACKGROUND: The atopic diseases asthma, atopic dermatitis, and allergic rhinitis are the most common chronic diseases in children, and their prevalence has increased recently in industrialized nations. Little is known about the genetic-environmental interaction factors driving such proliferation....... OBJECTIVE: To investigate the relationships among genetic, environmental, and lifestyle factors in the development of atopic diseases in high-risk children with the aim of developing evidence-based prevention strategies. METHODS: The Copenhagen Prospective Study on Asthma in Childhood is a single......-center, birth cohort study of children of asthmatic mothers. Objective assessments begin at birth, with scheduled visits every 6 months and when acute symptoms manifest. Clinical outcomes comprise preasthma, asthma, atopic dermatitis, allergic rhinitis, allergy, lung function, and bronchial responsiveness...

  1. Prospects for quarkonia production studies in U+U collisions

    CERN Document Server

    Kikoła, Daniel; Vogt, Ramona

    2011-01-01

    Collisions of deformed uranium nuclei provide a unique opportunity to study the spatial dependence of charmonium in-medium effects. By selecting the orientations of the colliding nuclei, different path lengths through the nuclear medium could be selected within the same experimental environment. In addition, higher energy densities can be achieved in U+U collisions relative to Au+Au collisions. In this paper, we investigate the prospects for charmonium studies with U+U collisions. We discuss the effects of shadowing and nuclear absorption on the J/\\psi\\ yield. We introduce a new observable which could help distinguish between different types of J/\\psi\\ interactions in hot and dense matter.

  2. The effects of an 8-week multicomponent inpatient treatment program on body composition and anaerobic fitness in overweight and obese children and adolescents

    Directory of Open Access Journals (Sweden)

    Karner-Rezek K

    2013-03-01

    Full Text Available Klaus Karner-Rezek,1 Beat Knechtle,2,3 Matthias Fenzl,4 Christian Schlegel,4 Manuela Konrad,5 Thomas Rosemann2 1Private University of the Principality of Liechtenstein, Triesen, Principality of Liechtenstein, 2Institute of General Practice and for Health Services Research, University of Zurich, Zurich, Switzerland; 3Gesundheitszentrum St Gallen, St Gallen, Switzerland; 4Swiss Olympic Medical Center, Medizinisches Zentrum Bad Ragaz, Switzerland; 5University of Applied Sciences JOANNEUM, Bad Gleichenberg, Austria Background: High intensity exercise is considered as an effective means for reducing body fat. The aims of the present study were to investigate (1 whether body mass would be lost and body composition would change and (2 whether variables of anaerobic fitness prior to the intervention period would be related to loss of body mass and changes in body composition in overweight and obese children and adolescents. Methods: A total of 28 children and adolescents (19 boys, 9 girls attended an 8-week multicomponent inpatient program. Caloric intake was based on the subject's weight and a daily energy deficit of ~500 kcal was targeted. At the beginning and at the end of the program, variables of anaerobic fitness were assessed using Wingate tests. Body composition was measured before and after the program using dual-energy X-ray absorptiometry. Results: Body mass decreased by 11.4% ± 1.6% in boys and by 11.0% ± 2.8% in girls (P < 0.001. Fat mass decreased by 23.8% ± 6.1% in boys and by 21.5% ± 5.2% in girls (P < 0.001. The decrease in fat mass was associated with the decrease in body mass in boys (r = 0.54, P = 0.017 but not in girls (P > 0.05. The decrease in body mass and the decrease in fat mass were neither associated with overall energy expenditure nor with the energy deficit in both genders (P > 0.05. Mean power in W/kg increased in the Wingate tests by 95.4% ± 109.1% in boys and by 100.0% ± 119.9% in girls (P < 0.001. Conclusions

  3. A Model of Microteaching Lesson Study Implementation in the Prospective History Teacher Education

    Science.gov (United States)

    Utami, Indah Wahyu Puji; Mashuri; Nafi'ah, Ulfatun

    2016-01-01

    Microteaching lesson study is a model to improve prospective teacher quality by incorporating several element of microteaching and lesson study. This study concern on the implementation of microteaching lesson study in prospective history teacher education. Microteaching lesson study model implemented in this study consist of three stages: plan,…

  4. Early breastfeeding experiences of adolescent mothers: a qualitative prospective study

    Directory of Open Access Journals (Sweden)

    Smith Paige Hall

    2012-09-01

    Full Text Available Abstract Background Teen mothers face many challenges to successful breastfeeding and are less likely to breastfeed than any other population group in the U.S. Few studies have investigated this population; all prior studies are cross-sectional and collect breastfeeding data retrospectively. The purpose of our qualitative prospective study was to understand the factors that contribute to the breastfeeding decisions and practices of teen mothers. Methods This prospective study took place from January through December 2009 in Greensboro, North Carolina in the U.S. We followed the cohort from pregnancy until two weeks after they ceased all breastfeeding and milk expression. We conducted semi-structured interviews at baseline and follow-up, and tracked infant feeding weekly by phone. We analyzed the data to create individual life and breastfeeding journeys and then identified themes that cut across the individual journeys. Results Four of the five teenagers breastfed at the breast for nine days: in contrast, one teen breastfed exclusively for five months. Milk expression by pumping was associated with significantly longer provision of human milk. Breastfeeding practices and cessation were closely connected with their experiences as new mothers in the context of ongoing multiple roles, complex living situations, youth and dependency, and poor knowledge of the fundamentals of breastfeeding and infant development. Breastfeeding cessation was influenced by inadequate breastfeeding skill, physically unpleasant and painful early experiences they were unprepared to manage, and inadequate health care response to real problems. Conclusions Continued breastfeeding depends on a complex interplay of multiple factors, including having made an informed choice and having the skills, support and experiences needed to sustain the belief that breastfeeding is the best choice for them and their baby given their life situation. Teenagers in the US context need to have

  5. Harmonic scalpel tonsillectomy versus monopolar diathermy tonsillectomy: a prospective study.

    Science.gov (United States)

    Roth, Jason A; Pincock, Tobias; Sacks, Raymond; Forer, Martin; Boustred, Neil; Johnston, William; Bailey, Michael

    2008-06-01

    For tonsillectomy, the ultrasonic harmonic scalpel has been purported to cause less tissue injury and postoperative morbidity while providing adequate levels of hemostasis. We undertook a prospective study to compare outcomes in 162 patients who had undergone harmonic scalpel tonsillectomy and 40 patients who had undergone monopolar diathermy tonsillectomy over a 33-month period. We found that patients in the harmonic scalpel group experienced significantly less intraoperative bleeding (5.0 vs. 16.5 ml; p < 0.0001). There was no clinically significant difference between the groups with respect to (1) the amount of operating time, (2) the incidence of postoperative nausea and vomiting, dysphonia, and primary or secondary bleeding, and (3) the amount of time patients needed to resume normal diet and activities. PMID:18561118

  6. Prospective study of chronic pain after groin hernia repair

    DEFF Research Database (Denmark)

    Callesen, T; Bech, K; Kehlet, H

    1999-01-01

    BACKGROUND: The aim was to provide a detailed description of any residual pain 1 year after elective day-case open groin hernia repair under local anaesthesia. METHODS: This was a prospective consecutive case series study by questionnaire of 500 consecutive operations in 466 unselected adult...... severe pain 4 weeks after operation (24 versus 3 per cent; P < 0.001). CONCLUSION: Chronic pain is a significant problem after open groin hernia repair. It may be worse after surgery for a recurrent hernia and may be predicted by the intensity of early postoperative pain....... severe pain was higher after repair of recurrent than primary hernias (14 versus 3 per cent; P < 0.001). The risk of developing moderate or severe pain was increased in patients who had a high pain score 1 week after operation (9 versus 3 per cent; P < 0.05) and also in patients who had moderate or...

  7. Immediate postoperative complications in transsphenoidal pituitary surgery: A prospective study

    Directory of Open Access Journals (Sweden)

    Tumul Chowdhury

    2014-01-01

    Full Text Available Background: Considering the important role of pituitary gland in regulating various endocrine axes and its unique anatomical location, various postoperative complications can be anticipated resulting from surgery on pituitary tumors. We examined and categorized the immediate postoperative complications according to various tumor pathologies. Materials and Methods: We carried out a prospective study in 152 consecutive patients and noted various postoperative complications during neurosurgical intensive care unit stay (within 48 hrs of hospital stay in patients undergoing transsphenoidal removal of pituitary tumors. Results: In our series, various groups showed different postoperative complications out of which, cerebrospinal fluid leak was the commonest followed by diabetes insipidus, postoperative nausea and vomiting, and hematoma at operation site. Conclusion: Various immediate postoperative complications can be anticipated in transsphenoidal pituitary surgery even though, it is considered to be relatively safe.

  8. Incense use and respiratory tract carcinomas: a prospective cohort study

    DEFF Research Database (Denmark)

    Yuan, J.M.; Wang, R.; Koh, W.P.;

    2008-01-01

    BACKGROUND: Incense use is an integral part of daily life in large parts of Asia. The burning of incense is a powerful producer of particulate matter and the smoke contains a multitude of well-characterized carcinogens. However, to the authors' knowledge, no convincing association has been reported...... between exposure to incense smoke and the development of cancer. Therefore, the relation between incense use and the risk of respiratory tract carcinomas was analyzed in a prospective cohort study. METHODS: Between 1993 and 1998, a population-based cohort of 61,320 Singapore Chinese who were free...... with incense use was estimated using a Cox proportional hazards model. RESULTS: A total of 325 upper respiratory tract (UPT) carcinomas and 821 lung carcinomas were observed during follow-up. Incense use was associated with a significantly increased risk of UPT carcinomas other than nasopharyngeal, whereas...

  9. Prospective study on microscopic potential with Gogny interaction

    Energy Technology Data Exchange (ETDEWEB)

    Blanchon, G.; Dupuis, M. [DAM, DIF, CEA, Arpajon (France); Arellano, H.F. [University of Chile, Department of Physics - FCFM, Santiago (Chile); DAM, DIF, CEA, Arpajon (France)

    2015-12-15

    We present our current studies and future plans on microscopic potential based on effective nucleon-nucleon interaction and many-body theory. This framework treats in an unified way nuclear structure and reaction. It offers the opportunity to link the underlying effective interaction to nucleon scattering observables. The more consistently connected to a variety of reaction and structure experimental data the framework is, the more constrained the effective interaction will be. As a proof of concept, we present some recent results for both neutron and proton scattered from spherical target nucleus, namely {sup 40}Ca, using the Gogny D1S interaction. Possible fruitful cross-talks between microscopic potential, phenomenological potential and effective interaction are exposed. We then draw some prospective plans for the forthcoming years including scattering from spherical nuclei experiencing pairing correlations, scattering from axially deformed nuclei, and new effective interaction with reaction constraints. (orig.)

  10. Cognitive function in the affective disorders: a prospective study.

    Science.gov (United States)

    Bulbena, A; Berrios, G E

    1993-01-01

    A prospective, controlled study of 50 subjects confirmed claims that major depression or mania may cause temporary disorders of attention, memory, visuo-spatial function, and choice reaction time, and cause-independently of medication-the appearance of glabellar tap, positive hand-face test, nuchocephalic reflex, and graphesthesia. On follow-up, all these phenomena either disappeared or markedly improved. Age and age of onset, but not pre-morbid intelligence or history of ECT, seemed to modulate the severity of the cognitive impairment. Presence of delusions predicted poor (but reversible) visuo-spatial function. Cognitive impairment accompanied by reversible soft neurological signs was more marked but patients thus affected surprisingly showed lower depressive scores; this was interpreted as representing a secondary, 'organic' form of affective disorder (i.e. a behavioural phenocopy of depression) characterised by a reduced capacity to experience depressive symptoms and by little improvement at follow-up.

  11. Prospective study of strongyloidosis in patients with hematologic malignancies

    Directory of Open Access Journals (Sweden)

    Graeff-Teixeira Carlos

    1997-01-01

    Full Text Available Immunocompromised individuals infected with Strongyloides stercoralis may develop severe hyperinfection or disseminated disease with high mortality. Patients with hematological malignancies are at risk because of immunodepression produced either by the disease or its treatment. A prospective study was undertaken at the Hospital de Clínicas de Porto Alegre, from July 1994 to July 1995. Seventy-two (HIV negative, had 3 stool samples collected at different days and had not received recent anti-helmintic therapy. Larvae, isolated in a modified Baermann method, were found in 6 patients, with a resultant prevalence of 8.3%. No complicated strongyloidosis was documented. The positive result for S. stercoralis larvae was significantly associated (p < 0.001 with eosinophilia. Knowledge of prevalence figures and incidence of severe disease is important to adequate guidelines for empirical treatment besides the rigorous search for strongyloidosis in patients with hematological malignancies.

  12. Hysteroscopic evaluation in infertile patients: a prospective study

    Directory of Open Access Journals (Sweden)

    Latika Sahu

    2012-12-01

    Full Text Available Background: Hysteroscopy is the gold standard procedure for uterine cavity exploration. However, hysteroscopy is only recommended by the WHO when clinical or complementary exams (ultrasound, HSG suggest intrauterine abnormality or after in vitro fertilization failure. Nevertheless, many specialists feel that hysteroscopy is a more accurate tool. The aim of this prospective study is to assess the value of diagnostic hysteroscopy in a primary workup of infertility by describing hysteroscopy findings in a population of 324 infertile patients during 18 months (December 2010 - May 2012. Methods: We analysed prospectively 324 infertile patients in gynaecology OT setting. Diagnostic video-assisted hysteroscopy was performed using a flexible hysteroscope. Hysteroscopy was performed with a standard sequence, inspecting the endocervical canal, uterine cavity, endometrium, and tubal ostia and findings recorded. Results: Hysteroscopy was normal in 65.12% of patients. Cervico-isthmic abnormalities were present in 6.48% of patients with cervical stenosis being the major abnormality. Uterine cavity was normal in 86% of patients. Observed abnormalities were septate uterus in 10 cases, intrauterine synechiae in 16 cases, sub mucus myoma in 2 cases, deformed cavity in 10 cases and endometrial polyp in 2 cases. Ostial fibrosis was observed in 29 patients. Endometrial abnormalities (fibrosis, inflammation were observed in 30 patients. Seven patients turned out to be of genital tuberculosis with endometrial biopsy. No significance was found regarding the total number of intrauterine pathologies when comparing the groups of primary versus secondary infertility. Conclusions: Rates of abnormal findings in infertile patient who underwent diagnostic hysteroscopy was 34.88% in our study. Our data are an additional argument to suggest hysteroscopy as part of investigation in infertile woman. Routine diagnostic hysteroscopy should be part of an infertility workup in primary

  13. Barium swallow study in routine clinical practice: a prospective study in patients with chronic cough

    Directory of Open Access Journals (Sweden)

    Carlos Shuler Nin

    2013-12-01

    Full Text Available OBJECTIVE: To assess the routine use of barium swallow study in patients with chronic cough.METHODS: Between October of 2011 and March of 2012, 95 consecutive patients submitted to chest X-ray due to chronic cough (duration > 8 weeks were included in the study. For study purposes, additional images were obtained immediately after the oral administration of 5 mL of a 5% barium sulfate suspension. Two radiologists systematically evaluated all of the images in order to identify any pathological changes. Fisher's exact test and the chi-square test for categorical data were used in the comparisons.RESULTS: The images taken immediately after barium swallow revealed significant pathological conditions that were potentially related to chronic cough in 12 (12.6% of the 95 patients. These conditions, which included diaphragmatic hiatal hernia, esophageal neoplasm, achalasia, esophageal diverticulum, and abnormal esophageal dilatation, were not detected on the images taken without contrast. After appropriate treatment, the symptoms disappeared in 11 (91.6% of the patients, whereas the treatment was ineffective in 1 (8.4%. We observed no complications related to barium swallow, such as contrast aspiration.CONCLUSIONS: Barium swallow improved the detection of significant radiographic findings related to chronic cough in 11.5% of patients. These initial findings suggest that the routine use of barium swallow can significantly increase the sensitivity of chest X-rays in the detection of chronic cough-related etiologies.

  14. 75 FR 9902 - Proposed Collection; Comment Request; The Agricultural Health Study: A Prospective Cohort Study...

    Science.gov (United States)

    2010-03-04

    ... history information for respondents enrolled in the Agriculture Health Study. This represents a request to... Health Study: A Prospective Cohort Study of Cancer and Other Disease Among Men and Women in Agriculture... Disease Among Men and Women in Agriculture (NCI) (OMB : 0925-0406). Type of Information Collection...

  15. Kartini Research Reactor prospective studies for neutron scattering application

    Energy Technology Data Exchange (ETDEWEB)

    Widarto [Yogyakarta Nuclear Research Center, BATAN (Indonesia)

    1999-10-01

    The Kartini Research Reactor (KRR) is located in Yogyakarta Nuclear Research Center, Yogyakarta - Indonesia. The reactor is operated for 100 kW thermal power used for research, experiments and training of nuclear technology. There are 4 beam ports and 1 column thermal are available at the reactor. Those beam ports have thermal neutron flux around 10{sup 7} n/cm{sup 2}s each other and used for sub critical assembly, neutron radiography studies and Neutron Activation Analysis (NAA). Design of neutron collimator has been done for piercing radial beam port and the calculation result of collimated neutron flux is around 10{sup 9} n/cm{sup 2}s. This paper describes experiment facilities and parameters of the Kartini research reactor, and further more the prospective studies for neutron scattering application. The purpose of this paper is to optimize in utilization of the beam ports facilities and enhance the manpower specialty. The special characteristic of the beam ports and preliminary studies, pre activities regarding with neutron scattering studies for KKR is presented. (author)

  16. Early carotid endarterectomy after a nondisabling stroke: a prospective study.

    Science.gov (United States)

    Ricco, J B; Illuminati, G; Bouin-Pineau, M H; Demarque, C; Camiade, C; Blecha, L; Neau, J P

    2000-01-01

    On the recommendation of several studies, carotid endarterectomy (CEA) should be delayed for at least 6 weeks in patients suffering an acute nondisabling stroke. Our objective was to determine if these patients could be safely operated on earlier, thus decreasing the risk of a recurrent stroke prior to surgery. This prospective study, carried out from January 1990 to December 1997, included 72 consecutive patients having a nondisabling hemispheric stroke with severe ipsilateral carotid stenosis (NASCET 70-99%). All patients underwent CEA within 15 days of stroke onset. Patients were considered to have a nondisabling hemispheric stroke if (1) symptoms of hemispheric ischemia persisted longer than 24 hr and (2) the resulting deficit caused no major impairment in their everyday activities. All patients were examined by a neurologist prior to carotid angiography and contrast CT scan. Hemorrhage seen on the initial CT scan eliminated the patient from the study. If the CT scan with contrast injection was negative, patients underwent magnetic resonance imaging. CEA was performed under general anesthesia with intraluminal shunting. All patients had a postoperative duplex scan and yearly follow-up by a neurologist and a surgeon, with a duplex scan of the carotid arteries. Mean follow-up was 53 months. Our study shows that CEA can be performed relatively safely within 15 days following an acute nondisabling stroke. The arbitrary 6-week delay for CEA may unnecessarily expose patients with high-grade stenosis to a recurrent stroke, which could be prevented by earlier surgery. PMID:10629271

  17. Incidence of ulcerative colitis in Central Greece: A prospective study

    Institute of Scientific and Technical Information of China (English)

    Spiros D. Ladas; Elias Mallas; Konstantinos Giorgiotis; Georgios Karamanolis; Dimitrios Trigonis; Apostolos Markadas; Vana Sipsa; Sotirios A. Raptis

    2005-01-01

    AIM: To study the incidence of ulcerative colitis UC in the prefecture of Trikala, Central Greece.METHODS: A prospective and population basedepidemiological study of UC from 1990 to the end of 1994was conducted. Trikala is a semirural prefecture of Central Greece with a population of 138 946 (census 1991). Three gastroenterologists (one hospital based, two private doctors)of the prefecture participated in this study.RESULTS: During the study period, 66 new histologically verified cases of UC were recorded. The mean annual incidence of the disease in 1990-1994 was 11.2 per 105inhabitants (95%CI: 8.7-14.3). There was no difference between men and women (annual incidence: 10.5 and 12.0 per 105 inhabitants respectively), either among urban,semirural or rural populations (annual incidence: 11.7,17.1 and 9.9 per 105 inhabitants respectively). The majority (56%) of the patients never smoked and a quarter were ex-smokers. About a half of all cases had proctitis.CONCLUSION: UC is common in Central Greece and its incidence is similar to that in North-Western European countries.

  18. [Psychic changes in systemic lupus erythematosus: a multidisciplinary prospective study].

    Science.gov (United States)

    Miguel Filho, E C; Pereira, R M; Busatto Filho, G; Shavitt, R G; Hirsch, R; de Sá, L C; de Arruda, P C

    1990-01-01

    Despite the high prevalence of psychic symptoms in lupus patients, there are few systematic studies in this area. Through a multidisciplinary approach, the authors developed a prospective study to characterize and correlate psychopathological aspects with clinical and laboratory data concerning neural manifestations of the disease. Out of 23 patients studied, 12 showed psychic alterations, which were interpreted as primary manifestations of the disease. All of them presented organic mental syndromes (DSM-III-R) in which cognitive symptoms were the most prominent, followed by affective, catatonic and hallucinatory features. The neurologic findings (seizure, migraine and muscular atrophy), as well as the ophthalmologic alterations (hemorrhage and soft exudates) were frequent and concomitant with the psychic features. The laboratory findings were: LE cells 50%; anti-Sm: 16%; anti-U1 RNP: 50%; anti-Ro/SS-A: 50%; anti-nDNA: 58%; decreased CH50 or fractions (C3, C4): 67%; anti-P: 18%; antigangliosides IgG: 67%; antigangliosides IgM: 78%. The cerebrospinal fluid analysis showed: increased cellularity: 18%; elevated protein: 36%; antigangliosides IgG: 67%; antigangliosides IgM: 33%; immunocomplexes: 36%. In spite of the absence of an adequate control group and of the small number of patients, the multidisciplinary approach leads to a better characterization of the nervous system involvement in this disease. PMID:1965671

  19. Prospective study of nutritional support during pelvic irradiation

    International Nuclear Information System (INIS)

    A prospective study of nutritional support during pelvic irradiation was carried out in 32 patients with a primary pelvic malignancy and prior weight loss. Both curative and palliative patients were eligible for the study. Seventeen patients were randomized to receive intravenous hyperalimentation (IVH) and fifteen patients served as controls who were maintained on their regular diet. Patients were stratified by percent body weight loss. Tolerance to therapy was assessed by evaluation of functional status and by using nutritional parameters of body weight change, change in serum protein levels, and response to delayed hypersensitivity skin tests. The curative IVH group tolerated therapy well by both functional and nutritional measurements. All curative IVH patients completed the planned radiation therapy without a treatment break and were fully active following treatment. Patients gained an average of 4.0 kg body weight during irradiation, which was significantly different from the curative control patients. They demonstrated a significant increase in serum transferrin reflecting an improvement in visceral protein. In addition, all showed a positive response to delayed hypersensitivity skin tests at the completion of irradiation. The palliative IVH patients often did poorly because of progression of disease and demonstrated only an elevation of serum transferrin during treatment. The results in the curative IVH group suggest a potential adjunctive role for intravenous hyperalimentation in the malnourished cancer patient undergoing pelvic irradiation. Clearly, further study of nutritional support during pelvic irradiation is needed using curative patients with a single tumor type and significant prior weight loss

  20. Study of geothermal prospects in the western United States

    Energy Technology Data Exchange (ETDEWEB)

    1976-08-20

    The commercial development potential of 13 underdeveloped geothermal prospects in the Western United States has been examined and the prospects have been ranked in order of relative potential for development on the basis of investment considerations. The following were considered in the ranking: geotechnical and engineering data, energy market accessibility, administrative constraints, and environmental and socio-economic factors. The primary ranking criterion is the unit cost of energy production expected from each prospect. This criterion is obtained principally from expected reservoir temperatures and depths. Secondary criteria are administrative constraints, environmental factors and the quality of the geotechnical data. The Roosevelt, Utah, prospect ranks first in development potential followed in order by Beowawe, Nevada; Coso Hot Springs, California; Long Valley, California; and Brady's Hot Springs, Nevada.

  1. Study of geothermal prospects in the western United States

    Energy Technology Data Exchange (ETDEWEB)

    1975-01-01

    The commercial development potential of 13 underdeveloped geothermal prospects in the western United States has been examined and the prospects have been ranked in order of relative potential for development on the basis of investment considerations. The following were considered in the ranking: geotechnical and engineering data, energy market accessibility, administrative constraints, and environmental and socio-economic factors. The primary ranking criterion is the unit cost of energy production expected from each prospect. This criterion is obtained principally from expected reservoir temperatures and depths. Secondary criteria are administrative constraints, environmental factors and the quality of the geotechnical data. The Roosevelt, Utah, prospect ranks first in development potential followed in order by Beowawe, Nevada; Coso Hot Springs, California; Long Valley, California; and Brady's Hot Springs, Nevada.

  2. Hyperglycemia in bacterial meningitis: a prospective cohort study

    NARCIS (Netherlands)

    E.S. Schut; W.F. Westendorp; J. de Gans; N.D. Kruyt; L. Spanjaard; J.B. Reitsma; D. van de Beek

    2009-01-01

    ABSTRACT: BACKGROUND: Hyperglycemia has been associated with unfavorable outcome in several disorders, but few data are available in bacterial meningitis. We assessed the incidence and significance of hyperglycemia in adults with bacterial meningitis. METHODS: We collected data prospectively between

  3. Functional and structural vascular adaptations following 8 weeks of low volume high intensity interval training in lower leg of type 2 diabetes patients and individuals at high risk of metabolic syndrome

    DEFF Research Database (Denmark)

    Madsen, Søren Møller; Thorup, Anne Cathrine Sønderstgaard; Overgaard, Kristian;

    2015-01-01

    We wished to investigate the effects of 8 weeks of low volume high intensity interval training (HIIT) on endothelial function of popliteal artery and circulating cell adhesion molecules in type 2 diabetes (T2D) patients and matched controls (CON). Methods: Over 8 weeks, non-active T2D patients...

  4. Effect of an electronic nicotine delivery device (e-Cigarette on smoking reduction and cessation: a prospective 6-month pilot study

    Directory of Open Access Journals (Sweden)

    Papale Gabriella

    2011-10-01

    Full Text Available Abstract Background Cigarette smoking is a tough addiction to break. Therefore, improved approaches to smoking cessation are necessary. The electronic-cigarette (e-Cigarette, a battery-powered electronic nicotine delivery device (ENDD resembling a cigarette, may help smokers to remain abstinent during their quit attempt or to reduce cigarette consumption. Efficacy and safety of these devices in long-term smoking cessation and/or smoking reduction studies have never been investigated. Methods In this prospective proof-of-concept study we monitored possible modifications in smoking habits of 40 regular smokers (unwilling to quit experimenting the 'Categoria' e-Cigarette with a focus on smoking reduction and smoking abstinence. Study participants were invited to attend a total of five study visits: at baseline, week-4, week-8, week-12 and week-24. Product use, number of cigarettes smoked, and exhaled carbon monoxide (eCO levels were measured at each visit. Smoking reduction and abstinence rates were calculated. Adverse events and product preferences were also reviewed. Results Sustained 50% reduction in the number of cig/day at week-24 was shown in 13/40(32.5% participants; their median of 25 cigs/day decreasing to 6 cigs/day (p Conclusion The use of e-Cigarette substantially decreased cigarette consumption without causing significant side effects in smokers not intending to quit (http://ClinicalTrials.gov number NCT01195597.

  5. A prospective study of collapsing focal segmental glomerulosclerosis.

    Science.gov (United States)

    Raja, Ramachandran; Nada, Ritambhra; Yadav, Ashok K; Kumar, Ashwani; Goyal, Ajay; Kumar, Vivek; Rathi, Manish; Kohli, H S; Gupta, K L; Sakhuja, Vinay; Jha, Vivekanand

    2016-07-01

    Collapsing focal segmental glomerulosclerosis (cFSGS) is characterized by rapid progression to end-stage renal disease (ESRD). We evaluated the clinicopathological spectrum of cFSGS and compared its clinical behavior to steroid and tacrolimus (TAC)-resistant noncollapsing focal segmental glomerulosclerosis (FSGS). All patients (>14 years) diagnosed with cFSGS were enrolled in the study. Staining for differentiated podocyte markers such as WT 1, PAX and KI67 were performed in all patients. The outcome and histological features of cFSGS was compared with a prospectively followed cohort of steroid and TAC-resistant noncollapsing FSGS. The study included 22 cFSGS patients and 19 cases of steroid and TAC-resistant FSGS. Complete remission, partial remission, steroid resistance, progression to ESRD and death were observed in 13.6%, 4.5%, 27.3%, 36.4% and 18.2% patients, respectively. Patients with cFSGS had higher serum creatinine and more advanced tubulointerstitial changes compared to resistant FSGS. Twenty-six percent of therapy resistant noncollapsing FSGS progressed to ESRD after two years of stopping TAC. However, there was no difference in progression to ESRD between cFSGS and therapy-resistant noncollapsing FSGS at the end of two years. Glomerular collapse in the setting of FSGS is poorly responsive to treatment and has a high rate of progression to ESRD. The long-term prognosis of cFSGS and steroid and TAC-resistant FSGS are similar.

  6. Superficial dermatomycoses: a prospective clinico-mycological study

    Directory of Open Access Journals (Sweden)

    Surekha A

    2015-01-01

    Full Text Available Background: Dermatomycoses are more prevalent in India due to favourable climatic conditions, poverty, poor hygiene and overcrowding. Sparse published data are available regarding superficial dermatomycoses from India. Methods: In this prospective study, demographic characteristics, clinical spectrum and risk factors for the development were studied in 198 patients with superficial dermatomycoses. Results: Their mean age was 34.1 ± 15.3 years; there were 108 (54.5% males. Majority of the patients (50.5% belonged to upper-lower socio-economic status (Class IV as per modified Kuppuswamy’s classification. Most of the patients (69.7% had presented with dermatophytoses. Among superficial dermatomy-coses, tinea corporis was the most common (29.3% clinical type. Potassium hydroxide mount was positive in 77.7% and culture was positive in 30.8%. Trichophyton rubrum was the most common species isolated (64%. Multivariable analysis using logistic regression revealed older age (> 50 years to be an independent predictor for the development of tinea corporis (p<0.001. Conclusions: Our observations suggest that superficial dermatomycoses are an important cause of morbidity and should be carefully searched for especially in the elderly so that effective curative treatment can be instituted.

  7. Biomarkers in differentiating clinical dengue cases: A prospective cohort study

    Directory of Open Access Journals (Sweden)

    Gary Kim Kuan Low

    2015-12-01

    Full Text Available Objective: To evaluate five biomarkers (neopterin, vascular endothelial growth factor-A, thrombomodulin, soluble vascular cell adhesion molecule 1 and pentraxin 3 in differentiating clinical dengue cases. Methods: A prospective cohort study was conducted whereby the blood samples were obtained at day of presentation and the final diagnosis were obtained at the end of patients’ follow-up. All patients included in the study were 15 years old or older, not pregnant, not infected by dengue previously and did not have cancer, autoimmune or haematological disorder. Median test was performed to compare the biomarker levels. A subgroup Mann-Whitney U test was analysed between severe dengue and non-severe dengue cases. Monte Carlo method was used to estimate the 2-tailed probability (P value for independent variables with unequal number of patients. Results: All biomarkers except thrombomodulin has P value < 0.001 in differentiating among the healthy subjects, non-dengue fever, dengue without warning signs and dengue with warning signs/severe dengue. Subgroup analysis for all the biomarkers between severe dengue and non-severe dengue cases was not statistically significant except vascular endothelial growth factor-A (P < 0.05. Conclusions: Certain biomarkers were able to differentiate the clinical dengue cases. This could be potentially useful in classifying and determining the severity of dengue infected patients in the hospital.

  8. A prospective clinical study of polycarboxylate cement in periapical surgery

    Science.gov (United States)

    Ortega-Sánchez, Bárbara; García-Mira, Berta; Maestre-Ferrín, Laura; Peñarrocha-Oltra, David; Gay-Escoda, Cosme

    2012-01-01

    Objective: To evaluate the clinical efficacy of polycarboxylate cement as retrograde filling material. Design: A prospective clinical study was made of 25 patients subjected to periapical surgery with ultrasound and magnifying loupes, in which polycarboxylate cement was used as retrograde filling material. Measurements were made of the area and diameter of the lesions pre- and postoperatively, and 6 and 12 months after the operation. The apical resection and retrograde filling areas were also measured, and the prognosis following surgery was recorded. Results: A total of 23 patients with 31 apicoectomized teeth were studied (2 patients being lost to follow-up). The mean area of the periapical lesions before surgery was 52.25 mm2, with a mean major diameter of 6.1 mm and a mean lesser diameter of 4.8 mm. The success rate after 12 months was 54.7%, according to the criteria of Von Arx and Kurt. The prognosis was poorer in females, in larger lesions, and in cases with larger retrograde filling areas. Conclusions: Polycarboxylate cement offers good results, with important bone regeneration after periapical surgery. Key words: Periapical surgery, endodontic treatment, polycarboxylate cement. PMID:22143701

  9. Diurnal Glycemic Patterns during an 8-Week Open-Label Proof-of-Concept Trial of Empagliflozin in Type 1 Diabetes.

    Directory of Open Access Journals (Sweden)

    Bruce A Perkins

    Full Text Available We recently reported improved glycemic control with reduced insulin dose in subjects with type 1 diabetes treated with the sodium glucose co-transporter-2 inhibitor empagliflozin. To further characterize the effects, we analyzed diurnal glycemic patterns by continuous glucose monitoring (CGM.In an 8-week single-arm open-label pilot study of empagliflozin, we compared ambulatory glucose profiles produced from CGM data during 2-week intervals in a placebo run-in baseline period, end-of-treatment, and post-treatment. Change in glycemic exposure was evaluated by area under the median curve according to time of day (AUCTOTAL 12:00am-11:55pm; AUCDAY 7:05am-10:55pm, AUCNIGHT 11:00pm-7:00am, as well as glycemic variability, glycemic stability and time-in-target (≥70 to ≤140mg/dL.The 40 patients (26 on insulin pump were aged 24±5 years and BMI 24.5±3.2 kg/m2. Consistent with the observed HbA1c decrease (8.0±0.9% to 7.6±0.9%, p<0.0001, normalized AUCTOTAL CGM decreased from 153.7±25.4 to 149.0±30.2mg/dL∙h at end-of-treatment (p = 0.31, and significantly increased post-treatment (164.1±29.5mg/dL∙h, p = 0.02. The numerical decrease in normalized AUCNIGHT (152.0±36.6 to 141.9±34.4mg/dL∙h, p = 0.13 exceeded AUCDAY (154.5±24.5 to 152.6±30.4mg/dL∙h, p = 0.65. Trends toward lower glycemic variability (83.1±18.9 to 75.6±28.6mg/dL, p = 0.06 and little change in glycemic stability (10.8±3.6 to 10.3±4.5mg/dL/h, p = 0.51 were observed. When empagliflozin was discontinued, these worsened relative to baseline (89.3±19.3mg/dL, p = 0.04 and 11.8±3.7mg/dL/hr, p = 0.08. Time-in-target numerically increased (40.2±11.9 to 43.1±13.5%, p = 0.69 at end-of-treatment but reversed post-treatment. Findings were similar on stratification of pump and MDI subjects.We observed that empagliflozin was associated with patterns of improved nighttime glycemia more prominent than daytime.Clinicaltrials.gov NCT01392560.

  10. Differences in kinetic variables between injured and noninjured novice runners : A prospective cohort study

    NARCIS (Netherlands)

    Bredeweg, Steef W.; Kluitenberg, Bas; Bessem, Bram; Buist, Ida

    2013-01-01

    Objectives: This prospective study examined differences in kinetic variables between injured and noninjured novice female and male runners and their potential contribution to RRIs. Design: A prospective cohort study. Methods: At baseline vertical ground reaction forces were assessed with an instrume

  11. Optimizing the definition of intrauterine growth restriction: the multicenter prospective PORTO Study.

    LENUS (Irish Health Repository)

    Unterscheider, Julia

    2013-04-01

    The objective of the Prospective Observational Trial to Optimize Pediatric Health in Intrauterine Growth Restriction (IUGR) (PORTO Study), a national prospective observational multicenter study, was to evaluate which sonographic findings were associated with perinatal morbidity and mortality in pregnancies affected by growth restriction, originally defined as estimated fetal weight (EFW) <10th centile.

  12. The Limitations of a Prospective Study of Memories for Child Sexual Abuse

    Science.gov (United States)

    Cheit, Ross E.

    2003-01-01

    Prospective studies have been held out as a kind of Holy Grail in research about remembering or forgetting child sexual abuse. They seem to hold the perfect answer to the verification problems that plague retrospective self-reports in the clinical literature. Prospective studies begin with verified cases of abuse. Then they require detective work…

  13. Screening for gestational diabetes mellitus by a model based on risk indicators: a prospective study

    DEFF Research Database (Denmark)

    Jensen, Dorte; Mølsted-Pedersen, Lars; Beck-Nielsen, Henning;

    2003-01-01

    This study was performed to prospectively evaluate a screening model for gestational diabetes mellitus on the basis of clinical risk indicators.......This study was performed to prospectively evaluate a screening model for gestational diabetes mellitus on the basis of clinical risk indicators....

  14. A PROSPECTIVE STUDY OF NEPHROTIC SYNDROME IN CHILDREN

    Directory of Open Access Journals (Sweden)

    Vijayalakshmi

    2015-05-01

    Full Text Available AIM OF THE STUDY: To study the incidence, age and sex related demographics in children with Nephrotic Syndrome (NS and to find the aetiology in atypical cases of NS by renal biopsy. MATERIALS AND METHOD S: The present study was a single centre, descriptive, prospective and observational cross sectional study. All patients who were admitted in the department of paediatrics with Nephrotic syndrome during the study period of 2 years from July 2010 to June 2012 were included. The demographics and renal biopsy results were analys ed further. RESULTS : Total number of cases of NS was 44 against total Paediatric admissions of 4827. Incidence of NS was 0.91% (44/4827 among all paediatric admissions. Male to female ratio was 2.14:1. Majority of NS cases were 3 - 5 years old (36.36%, n=44 , followed by 5 - 7 years (29.55%, n=44, 7 - 9 years (18.18%, n=44 and 1 - 3 years (15.91%, n=44. Total number of renal biopsies done was 18, out of which 14 (77.78%, n=18 had minimal change disease (MCNS and 3 (16.67%, n=18 had Focal Segmental Glomerulos clerosis (FSGS and 1 (5.55%, n=18 had anti Glomerular Basement Membrane disease. CONCLUSION: The incidence of Nephrotic syndrome in children was 0.91% (44/4827 among total paediatric admissions, had male preponderance with ratio of males to females of 2 .14:1, most commonly affecting children of 3 - 5 years of age and the most common aetiology being Minimal Change Disease (MCD.

  15. 77 FR 48993 - Proposed Collection; Comment Request; The Sister Study: A Prospective Study of the Genetic and...

    Science.gov (United States)

    2012-08-15

    ... Proposed Collection; Comment Request; The Sister Study: A Prospective Study of the Genetic and... Prospective Study of the Genetic and Environmental Risk Factors for Breast Cancer. Type of Information...-up of the Sister Study--a study of genetic and environmental risk factors for the development...

  16. 77 FR 66851 - Submission for OMB Review; Comment Request The Sister Study: A Prospective Study of the Genetic...

    Science.gov (United States)

    2012-11-07

    ...: A Prospective Study of the Genetic and Environmental Risk Factors for Breast Cancer SUMMARY: Under... Collection: Title: The Sister Study: A Prospective Study of the Genetic and Environmental Risk Factors for...: This is to continue the Phase II follow-up of the Sister Study -- a study of genetic and...

  17. Prospective cohort study of comprehensive prevention to gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Hai-Qiang Guo; Peng Guan; Hai-Long Shi; Xuan Zhang; Bao-Sen Zhou; Yuan Yuan

    2003-01-01

    AIM: To evaluate the preliminary effects of comprehensive prevention of gastric cancer in Zhuanghe County epidemiologically.METHODS: Stratified sampling and cluster sampling were applied to define the intervention group and the control group. The prospective cohort study was used for evaluating the effect of preventing gastric cancer. The relative risk (RR)and attributable risk percent (AR %) of intervention on gastric cancer death were calculated. Potential years of life lost (PLYY) of the disease was analyzed, and the RR and AR %of PYLL were calculated. Survival analysis was applied among the screened patients.RESULTS: In the first 4 years after intervening, the relative risk (RR) of intervention on death was 0.5059 (95 % CI:0.3462~0.7392,P<0.05) with significance statistically. AR %of the intervention on death was 49.41%. The RR of intervention on cumulative PYLL was 0.6778 (95 % CI:0.5604~0.8198,P<0.05) with statistic significance. AR %of the intervention on cumulative PYLL was 30.32 %. The four-year survival rate of the screened patients was 0.6751(95 % CI: 0.5298~0.9047).CONCLUSION: The initiative intervention results showed that the intervention approach used in the trial was effective, it reduced mortality and increased survival rate, and alleviated the adverse effect of gastric cancer on the health and life of screened population.

  18. Vocal Cord Paralysis and its Etiologies: A Prospective Study

    Directory of Open Access Journals (Sweden)

    Seyed Javad Seyed Toutounchi

    2014-03-01

    Full Text Available Introduction: Vocal cord paralysis is a common symptom of numerous diseases and it may be due to neurogenic or mechanical fixation of the cords. Paralysis of the vocal cords is just a symptom of underlying disease in some cases; so, clinical diagnosis of the underlying cause leading to paralysis of the vocal cords is important. This study evaluates the causes of vocal cord paralysis.Methods: In a prospective study, 45 patients with paralyzed vocal cord diagnosis were examined by tests such as examination of the pharynx, larynx, esophagus, thyroid, cervical, lung, and mediastinum, brain and heart by diagnostic imaging to investigate the cause vocal cord paralysis. The study was ended by diagnosing the reason of vocal cord paralysis at each stage of the examination and the clinical studies.Results: The mean duration of symptoms was 18.95±6.50 months. The reason for referral was phonation changes (97.8% and aspiration (37.8% in the subjects. There was bilateral paralysis in 6.82%, left paralysis in 56.82% and right in 63.36% of subjects. The type of vocal cord placement was midline in 52.8%, paramedian in 44.4% and lateral in 2.8% of the subjects. The causes of vocal cords paralysis were idiopathic paralysis (31.11%, tumors (31.11%, surgery (28.89%, trauma, brain problems, systemic disease and other causes (2.2%.Conclusion: An integrated diagnostic and treatment program is necessary for patients with vocal cord paralysis. Possibility of malignancy should be excluded before marking idiopathic reason to vocal cord paralysis.

  19. A prospective study of neuroendocrine and immune alterations associated with the stress of an oral academic examination among graduate students.

    Science.gov (United States)

    Lacey, K; Zaharia, M D; Griffiths, J; Ravindran, A V; Merali, Z; Anisman, H

    2000-05-01

    Stressful experiences may influence neuroendocrine, immune and cytokine functioning, as well as physical and psychological well being. The present prospective investigation assessed physiological and behavioral variations in anticipation of a critical oral academic examination among graduate students (i.e. related to a dissertation or comprehensive defense). Relative to matched control subjects, plasma cortisol levels were elevated among graduate students, especially females, 1 h prior to the oral examination, but not 6-8 weeks earlier (at about the time of the submission of the written document). In contrast, mitogen-stimulated (Con-A) lymphocyte proliferation was only reduced 6-8 weeks before the examination. Neither adrenocorticotrophic hormone (ACTH), prolactin, serum interleukin-1beta (IL-1beta) nor mitogen stimulated IL-1beta production was influenced at any time. Although, graduate students did not differ from controls with respect to perceived stress and feelings of mastery, they reported more frequent malaise (e.g. headaches, sore throat, fatigue) than did controls. The present findings suggest that during the course of lengthy anticipatory periods preceding a scheduled stressor, different stress-sensitive, situation-dependent biological processes may be engendered. It is further suggested that cortisol release is most closely aligned with immediate threats, while the immune alterations are sensitive to more distal events, or are subject to adaptation in response to a protracted stressor.

  20. A PROSPECTIVE STUDY ON MANAGEMENT OF INCISIONAL HERNIAS

    Directory of Open Access Journals (Sweden)

    Deepak R

    2014-06-01

    Full Text Available OBJECTIVE: To study the age and sex incidence, various factors leading to incisional hernia, methods to control them and various types of surgical repair by mesh and their complications. BACKGROUND DATA: Incisional hernia is a common surgical condition with a reported incidence of 5-11% of patients subjected to abdominal operations. Many factors are associated with incisional hernia like age, sex, obesity, chest infections, type of suture material, type of incision and most important wound infection. All of them present a challenging problem to the surgeon. So this study has been undertaken to assess the magnitude of this condition and different modalities in surgical repair by mesh in our setup. MATERIALS & METHODS: This is a prospective study of 70 cases of incisional hernia who attended to OPD and emergency department of Sri B. M. Patil medical college Hospital & Research Centre from March 2012 to March 2014. Data were collected from the patients ie, clinical history, examination and appropriate investigations. Documentations of patients which include identification, history, clinical finding, investigative tests, operation findings, operative procedures and complications during the stay in hospital and during subsequent follow up period, were all recorded in a proforma specially prepared. RESULTS: In our series of 70 patients, clinical details of 70 patients were available. Females (80%, n=48 out- numbered males (20%, n=12 and the highest incidence was in the age group of 30 to 60 years with mean age of 45 years. Gynecological operation accounted for 73.3% (n=50 of the index operations, with lower midline incision resulting in 53.3%(n=44 of the incisional hernias. The polypropylene mesh placed overlay or inlay method. All patients attended our follow up ranging from 3 months to 2 year. Two recurrences were noticed in inlay mesh repair group. CONCLUSION: Based on our analysis, we believe that overlay mesh repair is superior to inlay mesh

  1. Influence of tacrolimus on glucose metabolism before and after renal transplantation : a prospective study

    NARCIS (Netherlands)

    Duijnhoven, E M; Boots, J M; Christiaans, M H; Wolffenbuttel, B H; Van Hooff, J P

    2001-01-01

    Most studies concerning the influence of tacrolimus on glucose metabolism have been performed either in animals or after organ transplantation. These clinical studies have largely been transversal with patients who were using steroids. Therefore, this prospective, longitudinal study investigated the

  2. Development of PROSPECT detectors for precision antineutrino studies

    CERN Document Server

    Norcini, Danielle

    2015-01-01

    PROSPECT, the Precision Reactor Oscillation and Spectrum Experiment, will use two segmented detectors positioned 7-20 m from the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory to measure the U-235 antineutrino spectrum and perform a search for short-baseline oscillations as a signature of eV-scale sterile neutrinos. PROSPECT has developed Li-6 loaded liquid scintillator detectors for efficient identification of reactor antineutrinos and has measured reactor and cosmogenic backgrounds in the HFIR reactor building. Multiple test detectors have been built, operated, and characterized at HFIR and elsewhere to understand the optical performance of the scintillator and pulse-shape discrimination capabilities for enhanced background rejection. The results from this R&D effort are discussed, in the context of the design and physics potential of PROSPECT.

  3. Injury Rates in Iranian Taekwondo Athletes; a Prospective Study

    Directory of Open Access Journals (Sweden)

    Ziaee

    2010-03-01

    Full Text Available Purpose Taekwondo, as the most popular martial art among Iranian sportsmen, might lead to injury for the athletes of this sport during competitions. We decided to report the incidence rate of injuries sustained by the athletes of this sport during national competitions. Methods All competitions of Iran national championship taekwondo league in 2006-2007 with 204 athletes were observed prospectively to detect the occurrence of injuries. The severity of injuries was classified into four groups (mild, moderate, severe, and critical according to the involvement of medical care team in the contest, ability of the athletes to resume and duration of probable absence of injured athletes from future competitions and training sessions. Athlete-Exposure (A-E was defined as the number of competitions multiplied by two. On this base, the rate of injury incidence per 1000 A-Es, the rate of injuries per time unit and the rate of injury occurred for each 100 athletes were considered as the major outcomes of this study. Results Of totally 1,338 A-Es, 93 injuries were recorded during the competitions. The rate of injury incidence was found to be 69.5 injuries per 1000 A-Es and the rate of injuries per minute of competitions was 0.023 which corresponded to 23.3 injuries per 1000 minutes of competitions. 45.6 injuries were occurred for each 100 athletes during the course of competitions. The most frequent injuries were mild (68.8% and critical injuries (24.7%, followed by moderate and severe injuries; 4.3% and 2.1%, respectively. Conclusion The rate of injury we found was lower than that of western countries. In spite of finding the lower limbs as the most frequent place of injuries in other studies, we found the upper limbs as the most predisposed place of injuries which might be due to difference in the method of combat of Iranian athletes with other athletes.

  4. A Prospective Cohort Study of Mineral Metabolism After Kidney Transplantation

    Science.gov (United States)

    Wolf, Myles; Weir, Matthew R.; Kopyt, Nelson; Mannon, Roslyn B.; Von Visger, Jon; Deng, Hongjie; Yue, Susan; Vincenti, Flavio

    2016-01-01

    Background Kidney transplantation corrects or improves many complications of chronic kidney disease, but its impact on disordered mineral metabolism is incompletely understood. Methods We performed a multicenter, prospective, observational cohort study of 246 kidney transplant recipients in the United States to investigate the evolution of mineral metabolism from pretransplant through the first year after transplantation. Participants were enrolled into 2 strata defined by their pretransplant levels of parathyroid hormone (PTH), low PTH (>65 to ≤300 pg/mL; n = 112), and high PTH (>300 pg/mL; n = 134) and underwent repeated, longitudinal testing for mineral metabolites. Results The prevalence of posttransplant, persistent hyperparathyroidism (PTH >65 pg/mL) was 89.5%, 86.8%, 83.1%, and 86.2%, at months 3, 6, 9, and 12, respectively, among participants who remained untreated with cinacalcet, vitamin D sterols, or parathyroidectomy. The results did not differ across the low and high PTH strata, and rates of persistent hyperparathyroidism remained higher than 40% when defined using a higher PTH threshold greater than 130 pg/mL. Rates of hypercalcemia peaked at 48% at week 8 in the high PTH stratum and then steadily decreased through month 12. Rates of hypophosphatemia (<2.5 mg/dL) peaked at week 2 and then progressively decreased through month 12. Levels of intact fibroblast growth factor 23 decreased rapidly during the first 3 months after transplantation in both PTH strata and remained less than 40 pg/mL thereafter. Conclusions Persistent hyperparathyroidism is common after kidney transplantation. Further studies should determine if persistent hyperparathyroidism or its treatment influences long-term posttransplantation clinical outcomes. PMID:26177089

  5. Sugammadex versus neostigmine in pediatric patients: a prospective randomized study

    Directory of Open Access Journals (Sweden)

    Turhan Kara

    2014-12-01

    Full Text Available Background and objectives: Acetylcholinesterase inhibitors may cause postoperative residual curarization when they are used for reversal of neuromuscular blockade. Sugammadex reverses neuromuscular blockade by chemical encapsulation and is not associated with the side effects that may occur with the use of anticholinesterase agents. Because of increased outpatient surgical procedures postoperative residual curarization and rapid postoperative recovery have a greater importance in the pediatric patient population. The aim of this study was to compare the efficacy of sugammadex and neostigmine on reversing neuromuscular blockade in pediatric patients undergoing outpatient surgical procedures. Methods: 80 patients, aged 2-12 years, scheduled for outpatient surgery were enrolled in this randomized prospective study. Neuromuscular blockade was achieved with 0.6 mgkg−1 rocuronium and monitorized with train-of-four. Group RN (n = 40 received 0.03 mgkg−1 neostigmine, Group RS (n = 40 received 2 mgkg−1 sugammadex for reversal of rocuronium. Extubation time (time from the reversal of neuromuscular blockade to extubation, train-of-four ratio during this time, time to reach train-of-four > 0.9, and probable complications were recorded. Results: There was no significant difference between the patients' characteristics. Extubation time and time to reach train-of-four > 0.9 were significantly higher in Group RN (p = 0.001, p = 0.002. Train-of-four at the time of neostigmine/sugammadex injection in Group RN were significantly higher than in the RS group (p = 0.020. Extubation train-of-four ratio was significantly lower in Group RN (p = 0.002. Conclusion: Sugammadex provides safer extubation with a shorter recovery time than neostigmine in pediatric patients undergoing outpatient surgical procedures.

  6. [Soccer injuries. A prospective epidemiological and socioeconomic study].

    Science.gov (United States)

    Jensen, K H; Lindblad, B E; Terkelsen, C J; Helleland, H E; Terkelsen, C J

    1993-11-01

    In one year 715 soccer injuries were registered and treated in the casualty ward of Randers City Hospital. We conducted a prospective study of these patients, using a questionnaire in order to determine the most common locations, types, mechanisms and treatments of injury. Financial costs to society and the individual were also examined. Finally, we compared the most common types of injury definition in sports medicine. According to the Abbreviated Injury Scale, A.I.S., 44% of the injuries were classified as minor, 46% as moderate injury and 9% as severe. Fractures accounted for 17% of all injuries. Sprains and contusions were the most frequent injuries, accounting for 46% and 25% respectively. Most injuries (63%) were treated in the casualty ward, whilst 20% were treated as outpatients. 7% were admitted to the hospital immediately, and a further 2% were later admitted from the outpatient clinic. A total of 88% of those hospitalized were treated as inpatients for 1-7 days, and 12% for more than two weeks. 31% of all the soccer players seen in the casualty ward were absent from work, and 12% were absent from work for more than three weeks. 8% of the injured soccer players suffered loss of income. 40% had financial losses between $0-250, 40% between $250-750, seven per cent between $750-1,250, and 14% more than $1,250. From the data presented in this study, we conclude that the injury rate among soccer players increases with age, and the severity of the injuries is greatest in the oldest age groups. Soccer injuries constitute the major part of sports injuries seen in the casualty ward.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8256352

  7. NEONATAL OUTCOME IN ANEMIC MOTHERS: A PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Nisha

    2013-10-01

    Full Text Available BACKGROUND: Sepsis is the commonest cause of neonatal mortality .It is responsible for 30 - 50% of neonatal deaths in developing countries. Anemia during pregnancy is highly prev alent in India. Anemia in pregnancy has adverse effects on maternal and fetal health. Obstetrical complications like low birth weight babies, IUGR, increased rate of preterm deliveries & increased perinatal mortality are known. OBJECTIVES: Primary: To find relation between maternal anemia and proven neonatal sepsis. Secondary: To find long term morbidity and mortality of babies born to anemic mother. METHODS: The study was carried out in the Department of Pediatrics and Obstetrics and Gynaecology, Dr. B. R. Ambedkar Medical College and Hospital, Bangalore for a period of two years. A prospective randomized study conducted on 200 pregnant women who were found to be anaemic. All subjects were analyzed in full details and hemoglobin estimation done during 1 st v isit, at 30 th week and 36 th week of gestation. Blood cultures were done in all the babies admitted to NICU for various reasons. RESULTS: The incidence of mild anaemia 29.5%, moderate anemia 53% and 17.5% severe anaemia was noted in mothers. Out of total 20 0, 194 were liveborn and met the inclusion criteria, 20% were preterm, 28% IUGR, 51 babies(25 % required NICU admission due to various reasons out of which 9% developed proven sepsis. CONCLUSION: Anaemia in pregnancy continues to be a major problem in dev eloping countries with maternal and fetal complications and neonatal sepsis was found to be indirectly associated with maternal anaemia.

  8. Psychological adaptation and social support of parents of pediatric cancer patients : A prospective longitudinal study

    NARCIS (Netherlands)

    Hoekstra-Weebers, JEHM; Jaspers, JPC; Kamps, WA; Klip, EC

    2001-01-01

    Objective: To investigate levels of support and the concurrent and prospective effects of support on the psychological functioning of parents of children with cancer in a prospective longitudinal study. Methods: Parents' (n = 128) self-perceived level of psychological distress, quantity of support,

  9. A prospective study of radioimmunoscintigraphy in ovarian cancer

    International Nuclear Information System (INIS)

    The aim of this first prospective study using a monoclonal antibody labelled with I-123 was to determine its clinical potential. 30 patients with pelvic tumour, diagnosis known only to the gynaecological oncologists were referred and imaged at 10 min, 4h and 22h using human milk fat globule monoclonal antibody HMFG2 labelled using the iodogen technique with pure I-123 (2.5mCi injected). Images were reported without clinical information as negative or positive for ovarian cancer OC and its distribution mapped. Surgery and histology were assessed independently by the oncologists and the patients finally classified into group I: 10 with benign or non ovarian malignant disease and group II: 20 with OC in whom the sites of biopsy positive disease were also mapped. In group 1 5/10 patients showed the pattern of OC indicating that the technique is unsuccessful as a screening test due to the lack of specificity - uptake by liver, stomach and colon metastases being seen. In group II the distribution of OC primary and metastases was correct in 18/20, 90%. A new technique based on the kinetics of antibody uptake by the tumour using an algorithm which converts the data to a probability map based on the significance of the differences in distribution between the early and later images, correctly localised two 0.5cm biopsy positive OC tumours in one of the failures in group II. These results slow that radioimmunoscintigraphy will contribute to staging and evaluating chemotherapy in known OC

  10. Pros and cons of a wandering mind: A prospective study

    Directory of Open Access Journals (Sweden)

    Cristina eOttaviani

    2013-08-01

    Full Text Available Mind wandering (MW has recently been associated with both adaptive (e.g., creativity enhancement and maladaptive (e.g., mood worsening consequences. This study aimed at investigating whether proneness to MW was prospectively associated with negative health outcomes. At time 0, 21 women, 19 men; mean age = 24.5 (4.9 underwent a 5-min baseline electrocardiogram (ECG, a 20-min laboratory tracking task with thought probes, and personality questionnaires. At time 1 (1 year follow-up, the same participants underwent a 24-hour Ecological Momentary Assessment characterized by ambulatory ECG recording and electronic diaries. First, we examined if the likelihood of being a ‘mind wanderer’ was associated with specific personality dispositions. Then, we tested if the occurrence of episodes of MW in the lab would be correlated with frequency of MW in daily life. Finally, multiple regression models were used to test if MW longitudinally acted as a risk factor for health, accounting for the effects of biobehavioral variables. Among dispositional traits, the frequency of MW episodes in daily life was inversely associated with the capacity of being mindful (i.e., aware of the present moment and non-judging. There was a positive correlation between frequency of MW in the lab and in daily life, suggesting that it is a stable disposition of the individual. When differentiated from perseverative cognition (i.e., rumination and worry, MW did not predict the presence of health risk factors one year later, however, a higher occurrence of episodes of MW was associated with short-term adverse consequences, such as increased 24-hour heart rate on the same day and difficulty falling asleep the subsequent night. Present findings suggest that MW may be associated with short term ‘side effects’ but argue against a long term dysfunctional view of this cognitive process.

  11. [Treatment of prostate cancer using cryoablation: a prospective study].

    Science.gov (United States)

    Govorov, A V; Vasil'ev, A O; Ivanov, V Iu; Kovylina, M V; Prilepskaia, E A; Pushkar', D Iu

    2014-01-01

    prostate cancer and achieve a high disease-free survival. Our prospective study was aimed to analyze our own results cryoablation of the prostate gland. PMID:25799731

  12. An international, multicenter, prospective, observational study of neutropenia in patients being treated with lenalidomide + dexamethasone for relapsed or relapsed/refractory multiple myeloma (RR-MM).

    Science.gov (United States)

    Leleu, Xavier; Terpos, Evangelos; Sanz, Ramón García; Cooney, Julian; O'Gorman, Peter; Minarik, Jiri; Greil, Richard; Williams, Catherine; Gray, Diep; Szabo, Zsolt

    2016-08-01

    Neutropenia is a well-known dose-limiting toxicity associated with lenalidomide plus dexamethasone treatment in patients with multiple myeloma; however, little is known about its management and associated outcomes in the real world setting. The present prospective, multicenter, observational study evaluated the incidence, management, and outcomes of grade 3/4 neutropenia in patients with relapsed or relapsed/refractory multiple myeloma who initiated treatment with lenalidomide plus dexamethasone. Of 198 patients, 62 (31%, 95% CI: 25, 38) experienced grade 3/4 neutropenia, and half of these patients experienced 3 or more events during the 12-month observational period. Grade 3/4 neutropenia occurred throughout lenalidomide treatment, with a median time to first event of 8.8 weeks (Q1, Q3: 5.9, 17.3). In a multivariate analysis, diagnosis of relapsed and refractory disease was associated with grade 3/4 neutropenia. Lenalidomide exposure reduction, use of G-CSF, unplanned hospitalization, and outpatient clinic visits were more common in patients who experienced grade 3/4 neutropenia than in those who did not. In conclusion, grade 3/4 neutropenia is a common toxicity and patients are at continued risk throughout treatment with lenalidomide and dexamethasone. Further efforts should be made to improve the recommendations for neutropenia management in this population. Am. J. Hematol. 91:806-811, 2016. © 2016 Wiley Periodicals, Inc. PMID:27169523

  13. EFFECTIVENESS OF OPEN DISCECTOMY FOR IVDP – A PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Ranganath

    2014-02-01

    Full Text Available BACKGROUND AND OBJECTIVES: Low back pain (LBP results in loss in productivity than any other medical condition. Approximately 70 - 80% of all people will develop LBP in their life . There are various causes of LBP , out of which the lumber disc herniation is one of the most frequent reason for physical , functional restriction in patients. Patients who have u ndergone surgical treatment are found to possess increased short term outcome instead of conservative treated patients. Surgically treated patients experienced fast pain relief , improvement of function & satisfaction in comparison to conservative patients. The comparative results of patients treated with surgery and conservatively treated patients have revealed that surgical treatment is much better at short term follow up (upto 1 year however no variations have been shown among treatment at long term foll ow up. Some patients operated for spine diseases are still left with poor results. The present study aims to evaluate the efficiency of open discectomy for L 4 – L 5 IVDP prospectively. METHODS : 30 cases of lumbar disc prolapse , above 18 years of age admitte d at KIMS hospital , Bangalore with MRI showing conclusive disc prolapsed were taken for the study. They were pre operatively evaluated for their ODI score. Only those patients who have scored 40% and above in ODI were included in the study. They underwent dis c ectomy. Methods of surgery used were fenestration , extended fenestration , hemilaminectomy & total laminectomy as per operative requirement. Follow - ups were carried out at 6 , 12 and 24weeks on selected areas. Pre and post of ODI total and sub scale scor es were compared at the end of 24 weeks. RESULTS : There was a significant reduction of post operative ODI score indicating good success rate in open disectomy. The pre operative mean ODI score was 58.28 , SD was 5.06 and the post operative mean ODI score wa s 15.28 and SD was 2.40 with t value of 38.56 and p value of

  14. Injuries at a Canadian National Taekwondo Championships: a prospective study

    Directory of Open Access Journals (Sweden)

    Pieter Willy

    2004-07-01

    Full Text Available Abstract Background The purpose of this prospective study was to assess the injury rates in male and female adult Canadian Taekwondo athletes relative to total number of injuries, type and body part injured. Methods Subjects (219 males, 99 females participated in the 1997 Canadian National Taekwondo Championships in Toronto, Canada. Injuries were recorded on an injury form to documents any injury seen and treatment provided by the health care team. These data were later used for this study. The injury form describes the athlete and nature, site, severity and mechanism of the injury. Results The overall rate of injuries was 62.9/1,000 athlete-exposures (A-E. The males (79.9/1,000 A-E sustained significantly more injuries than the females (25.3/1,000 A-E. The lower extremities were the most commonly injured body region in the men (32.0 /1,000 A-E, followed by the head and neck (18.3/1,000 A-E. Injuries to the spine (neck, upper back, low back and coccyx were the third most often injured body region in males (13.8/1,000 A-E. All injuries to the women were sustained to the lower extremities. The most common type of injury in women was the contusion (15.2/1,000 A-E. However, men's most common type of injury was the sprain (22.8/1,000 A-E followed by joint dysfunction (13.7/1,000A-E. Concussions were only reported in males (6.9/1,000 A-E. Compared to international counterparts, the Canadian men and women recorded lower total injury rates. However, the males incurred more cerebral concussions than their American colleagues (4.7/1,000 A-E. Conclusions Similar to what was found in previous studies, the current investigation seems to suggest that areas of particular concern for preventive measures involve the head and neck as well as the lower extremities. This is the first paper to identify spinal joint dysfunction.

  15. Work characteristics predict psychiatric disorder: prospective results from the Whitehall II Study

    OpenAIRE

    Stansfeld, S. A.; Fuhrer, R; Shipley, M J; Marmot, M G

    1999-01-01

    OBJECTIVES: The impact of work on the risk of future psychiatric disorder has been examined in few longitudinal studies. This was examined prospectively in a large epidemiological study of civil servants. METHODS: In the Whitehall II study, a longitudinal, prospective cohort study of 6895 male and 3413 female London based civil servants, work characteristics measured at baseline (phase 1: 1985-8) and first follow up (phase 2: 1989) were used to predict psychiatric disorder measured by a...

  16. Dietary fiber intake and mortality among survivors of myocardial infarction: prospective cohort study

    OpenAIRE

    Li, Shanshan; Flint, Alan; Pai, Jennifer K.; Forman, John P.; Hu, Frank B.; Willett, Walter C.; Rexrode, Kathryn M.; Mukamal, Kenneth J; Rimm, Eric B

    2014-01-01

    Objective To evaluate the associations of dietary fiber after myocardial infarction (MI) and changes in dietary fiber intake from before to after MI with all cause and cardiovascular mortality. Design Prospective cohort study. Setting Two large prospective cohort studies of US women and men with repeated dietary measurements: the Nurses’ Health Study and the Health Professionals Follow-Up Study. Participants 2258 women and 1840 men who were free of cardiovascular disease, stroke, or cancer at...

  17. Dietary fiber intake and mortality among survivors of myocardial infarction: prospective cohort study

    OpenAIRE

    Li, Shanshan; Flint, Alan; Pai, Jennifer K.; Forman, John P.; Hu, Frank B.; Willett, Walter C.; Rexrode, Kathryn M.; Mukamal, Kenneth J; Rimm, Eric B

    2014-01-01

    Objective: To evaluate the associations of dietary fiber after myocardial infarction (MI) and changes in dietary fiber intake from before to after MI with all cause and cardiovascular mortality. Design: Prospective cohort study. Setting: Two large prospective cohort studies of US women and men with repeated dietary measurements: the Nurses’ Health Study and the Health Professionals Follow-Up Study. Participants: 2258 women and 1840 men who were free of cardiovascular disease, stroke, or cance...

  18. Clinical and functional outcomes of the PCCP study : a multi-center prospective study in Italy

    OpenAIRE

    Antonini, G.; Giancola, R.; D. Berruti; E. Blanchietti; Pecchia, P.; Francione, V.; Greco, P.; T.C. Russo; L. Pietrogrande

    2013-01-01

    The standard surgical management of hip fractures is associated with tissue trauma and bleeding which are added to the fracture injury. The percutaneous compression plate (PCCP) is a minimally invasive device that has been demonstrated in previous studies to reduce postoperative complications and blood loss. This prospective, multi-center, observational study assessed clinical and functional outcomes with PCCP as treatment for trochanteric fractures. Patients with a stable or unstable proxima...

  19. Reproducing a Prospective Clinical Study as a Computational Retrospective Study in MIMIC-II

    OpenAIRE

    Kury, Fabrício S. P.; Huser, Vojtech; Cimino, James J.

    2015-01-01

    In this paper we sought to reproduce, as a computational retrospective study in an EHR database (MIMIC-II), a recent large prospective clinical study: the 2013 publication, by the Japanese Association for Acute Medicine (JAAM), about disseminated intravascular coagulation, in the journal Critical Care (PMID: 23787004). We designed in SQL and Java a set of electronic phenotypes that reproduced the study’s data sampling, and used R to perform the same statistical inference procedures. All produ...

  20. Sleep-disordered breathing and mortality: a prospective cohort study.

    Directory of Open Access Journals (Sweden)

    Naresh M Punjabi

    2009-08-01

    Full Text Available BACKGROUND: Sleep-disordered breathing is a common condition associated with adverse health outcomes including hypertension and cardiovascular disease. The overall objective of this study was to determine whether sleep-disordered breathing and its sequelae of intermittent hypoxemia and recurrent arousals are associated with mortality in a community sample of adults aged 40 years or older. METHODS AND FINDINGS: We prospectively examined whether sleep-disordered breathing was associated with an increased risk of death from any cause in 6,441 men and women participating in the Sleep Heart Health Study. Sleep-disordered breathing was assessed with the apnea-hypopnea index (AHI based on an in-home polysomnogram. Survival analysis and proportional hazards regression models were used to calculate hazard ratios for mortality after adjusting for age, sex, race, smoking status, body mass index, and prevalent medical conditions. The average follow-up period for the cohort was 8.2 y during which 1,047 participants (587 men and 460 women died. Compared to those without sleep-disordered breathing (AHI: or=30.0 events/h sleep-disordered breathing were 0.93 (95% CI: 0.80-1.08, 1.17 (95% CI: 0.97-1.42, and 1.46 (95% CI: 1.14-1.86, respectively. Stratified analyses by sex and age showed that the increased risk of death associated with severe sleep-disordered breathing was statistically significant in men aged 40-70 y (hazard ratio: 2.09; 95% CI: 1.31-3.33. Measures of sleep-related intermittent hypoxemia, but not sleep fragmentation, were independently associated with all-cause mortality. Coronary artery disease-related mortality associated with sleep-disordered breathing showed a pattern of association similar to all-cause mortality. CONCLUSIONS: Sleep-disordered breathing is associated with all-cause mortality and specifically that due to coronary artery disease, particularly in men aged 40-70 y with severe sleep-disordered breathing. Please see later in the

  1. A prospective study of faecal bile acids and colorectal cancer.

    Science.gov (United States)

    Haines, A; Hill, M J; Thompson, M H; Owen, R W; Williams, R E; Meade, T W; Wilkes, H; Griffin, M

    2000-10-01

    A prospective study of 7079 people aged 45-74 recruited through general practices in South Wales, Herefordshire and Edinburgh, Scotland was undertaken to test the hypothesis that faecal bile acids are implicated in the causation of large bowel cancer. The population was recruited between 1974 and 1980 and the response rate for stool collection was 67%. Bile acid analyses were performed on those cases that presented by 1990. It was decided in advance to examine the hypothesis separately for left- and right-sided bowel cancer because of known epidemiological differences between the two sites and to exclude the cases presenting within 2 years of the stool sample from the analyses because the cancer could have been present at recruitment and might have possibly affected faecal bile acid concentrations. Each case (n = 51 left-sided and 8 right-sided) was matched with three controls by age (within 5 years), sex, place of residence and time of providing the stool sample (within 3 months). Statistical analyses using conditional logistic regression showed no significant differences between the left-sided cases and controls for any of the concentrations of individual bile acids, total bile acid concentrations, faecal neutral steroids, percentage bacterial conversion and the ratio of lithocholic acid to deoxycholic acid concentrations. There was a statistically significant (P = 0.021) association of the presence of chenodeoxycholic acid (5/8 samples) in the right-sided cases compared with the controls (3/23), odds ratio 6.26 (95% confidence interval 1.19, 32.84). A high proportion of primary bile acids has also been found in other studies of patients with a genetic predisposition to proximal bowel cancer, however this pattern may also occur in low risk groups, such as Indian vegetarians, suggesting that they may predispose to right-sided bowel cancer only in the presence of other, as yet unknown factors. If bile acids are involved in the causation of large bowel cancer, they

  2. Effect of cholecystectomy on bowel function: a prospective, controlled study

    OpenAIRE

    Hearing, S; Thomas, L.; HEATON, K; Hunt, L.

    1999-01-01

    BACKGROUND—Published estimates of the prevalence of postcholecystectomy diarrhoea derive from retrospective or uncontrolled data. They ignore functional bowel syndromes and possible changes in diet and drug use.
AIMS—To determine prospectively whether and how often cholecystectomy leads to changes in bowel function and bowel symptoms, especially to liquid stools, over and above any non-specific effect of laparoscopic surgery.
SUBJECTS—Patients: 106 adults undergoing laparoscopic cholecystecto...

  3. Volleyball injuries presenting in casualty: a prospective study.

    OpenAIRE

    Solgård, L; Nielsen, A B; Møller-Madsen, B; Jacobsen, B W; Yde, J; Jensen, J

    1995-01-01

    During 1986, all sports injuries (n = 5222) were prospectively recorded at the two casualty departments in Arhus, Denmark. Volleyball injuries (n = 278) accounted for 5.3% of all sports injuries. An evaluation of the rehabilitation period and the consequences of the injuries was undertaken by questionnaire three years after the injury. The injury incidence was 1.9 injuries/1000 inhabitants/year. Hand, finger, and ankle sprains were the most frequent injuries. Female players had significantly ...

  4. Right heart in septic shock: prospective observational study

    OpenAIRE

    Singh, Ratender Kumar; Kumar, Sudeep; Nadig, Sreevatsa; Baronia, Arvind Kumar; Poddar, Banani; Azim, Afzal; Gurjar, Mohan

    2016-01-01

    Background The right heart often receives less attention during echocardiography. The situation is no different in septic shock. We prospectively investigated the echocardiographic indices of the right heart in septic shock adult patients. Methods Septic shock ICU patients within 24 h of admission were subjected to transthoracic echocardiography (TTE) as per the 2005 guidelines from the American Society of Echocardiography. Results Eighty-eight septic shock patients (M:F = 52:36) underwent TT...

  5. Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study

    OpenAIRE

    Gallo, V; Vanacore, N; Bueno-de-Mesquita, HB; Vermeulen, R.; Brayne, C.; Pearce, N.; Wark, PA; Ward, HA; P. Ferrari; Jenab, M; Andersen, PM; P. Wennberg; Wareham, N.; Katzke, V; Kaaks, R

    2016-01-01

    Previous case–control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included in the analysis, yielding 219 ALS deaths. At recruitment, information on PA was collected tho...

  6. Acquisition Study On Cawthorne Channel Prospect For SPDC

    International Nuclear Information System (INIS)

    The Cawthorne Channel prospect area lies in the Niger River Delta of South Central Nigeria. During 1987 to 1988, 3D seismic was conducted by Western Geophysical Company. According to SPDC's project plan, 4D seismic or 3D re-shoot program will be carried out in the year of 2002, in order to improve seismic data quality, monitor the variations of reservoir, and further to locate the infill wells for improvement of oil output in Cawthorne Channel prospect. From the knowledge of previous 3D, medium to deeper layer reflections show the lower resolution with poor S/N ratio due to lower coverage and limited maximum offset. The purpose of this paper is to introduce one way of optimizing the acquisition parameters such as trace interval, maximum offset, source array pattern and receiver pattern according to the requirement of vertical resolution, horizontal resolution, target depth and maximum frequency components to be protected. Finally the 4D/3D geometries are proposed from the geophysical parameters for Cawthorne Channel prospect

  7. A prospective study of tobacco smoking and mortality in Bangladesh.

    Directory of Open Access Journals (Sweden)

    Fen Wu

    Full Text Available BACKGROUND: Limited data are available on smoking-related mortality in low-income countries, where both chronic disease burden and prevalence of smoking are increasing. METHODS: Using data on 20,033 individuals in the Health Effects of Arsenic Longitudinal Study (HEALS in Bangladesh, we prospectively evaluated the association between tobacco smoking and all-cause, cancer, and cardiovascular disease mortality during ∼7.6 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs and their 95% confidence intervals (CIs for deaths from all-cause, cancer, CVD, ischemic heart disease (IHD, and stroke, in relation to status, duration, and intensity of cigarette/bidi and hookah smoking. RESULTS: Among men, cigarette/bidi smoking was positively associated with all-cause (HR 1.40, 95% CI 1.06 1.86 and cancer mortality (HR 2.91, 1.24 6.80, and there was a dose-response relationship between increasing intensity of cigarette/bidi consumption and increasing mortality. An elevated risk of death from ischemic heart disease (HR 1.87, 1.08 3.24 was associated with current cigarette/bidi smoking. Among women, the corresponding HRs were 1.65 (95% CI 1.16 2.36 for all-cause mortality and 2.69 (95% CI 1.20 6.01 for ischemic heart disease mortality. Similar associations were observed for hookah smoking. There was a trend towards reduced risk for the mortality outcomes with older age at onset of cigarette/bidi smoking and increasing years since quitting cigarette/bibi smoking among men. We estimated that cigarette/bidi smoking accounted for about 25.0% of deaths in men and 7.6% in women. CONCLUSIONS: Tobacco smoking was responsible for substantial proportion of premature deaths in the Bangladeshi population, especially among men. Stringent measures of tobacco control and cessation are needed to reduce tobacco-related deaths in Bangladesh.

  8. Prospective study of melanoma in the Paris Region in 2004

    International Nuclear Information System (INIS)

    %) and less trunk localisation (from 37% to 30%) and legs localisation (from 32 % to 24%). Melanoma are more often diagnosed at in situ stage but they are also more frequently diagnosed at a advanced stage (Table 2). Bibliography: Baccard M., Havard S., Souques M. et le Groupe Melanome de PETRI. Etude prospective de l incidence du melanome dans la region Ile de France en 1994. Annales de Dermatologie et de Venereologie, 1995, 122: S142-143. Baccard M., Havard S., Souques M. and the PETRI Melanoma Group. Prospective study of the incidence of melanoma in Paris region in 1994. Melanoma Research, 1997, 7: 335-338. (authors)

  9. Is Isolated Aphasia Associated with Atrial Fibrillation A Prospective Study

    Directory of Open Access Journals (Sweden)

    Carlijn P.A. Giesbers

    2014-07-01

    Full Text Available Background: A cardioembolic source, usually atrial fibrillation (AF, is detected in 14-30% of strokes. If AF is found, anticoagulation therapy provides a substantial decrease of the risk of recurrent cerebrovascular ischemic events. AF is often paroxysmal, and extensive diagnostic procedures may be necessary to detect it in patients. Considering cost-effectiveness and patient burden, however, not every suspected patient can be thoroughly screened. Therefore, the identification of risk factors for AF may be helpful. Previous studies have identified isolated aphasia as a risk factor for AF as the cause of the stroke. These studies, however, were performed with small population samples, in a retrospective setting or focused on a specific subtype of aphasia. The aim of this observational study is to prospectively evaluate whether there is a relation between isolated aphasia and AF as the cause of cerebrovascular ischemia. Methods: All patients admitted to the Atrium Medical Centre, Heerlen, the Netherlands, with cerebrovascular ischemia or transient ischemic attack in the period of August 2009 to March 2010 or October 2013 to January 2014 were included. The patients were evaluated by a neurologist and admitted to the Brain Care Unit for 24-48 h. Medical history, physical examination and diagnostic results were entered in a database. A diagnosis of isolated aphasia was assigned at admission using the National Institutes of Health Stroke Scale (NIHSS. Presence of AF was determined using a 12-lead electrocardiogram (ECG on admission and continuous ECG monitoring for 1-2 days. During admission, aphasia tests were done, notably the ScreeLing Test and the Boston Naming Test. Data were analyzed using Pearson's χ2 test, Fisher's exact test, the Mann-Whitney U test and univariate and multivariate logistic regression analyses. Results: A total of 347 patients were included, of which 115 (33.1% met the criteria for aphasia, with 26 (7.5% meeting the criteria

  10. Increases in the right dorsolateral prefrontal cortex and decreases the rostral prefrontal cortex activation after-8 weeks of focused attention based mindfulness meditation.

    Science.gov (United States)

    Tomasino, Barbara; Fabbro, Franco

    2016-02-01

    Mindfulness meditation is a form of attention control training. The training exercises the ability to repeatedly focus attention. We addressed the activation changes related to an 8-weeks mindfulness-oriented focused attention meditation training on an initially naïve subject cohort. Before and after training participants underwent an fMRI experiment, thus, although not strictly a cross over design, they served as their internal own control. During fMRI they exercised focused attention on breathing and body scan as compared to resting. We found increased and decreased activation in different parts of the prefrontal cortex (PFC) by comparing pre- vs. post-mindfulness training (MT) during breathing and body scan meditation exercises that were compared against their own resting state. In the post-MT (vs. pre-MT) meditation increased activation in the right dorsolateral PFC and in the left caudate/anterior insula and decreased activation in the rostral PFC and right parietal area 3b. Thus a brief mindfulness training caused increased activation in areas involved in sustaining and monitoring the focus of attention (dorsolateral PFC), consistent with the aim of mindfulness that is exercising focused attention mechanisms, and in the left caudate/anterior insula involved in attention and corporeal awareness and decreased activation in areas part of the "default mode" network and is involved in mentalizing (rostral PFC), consistent with the ability trained by mindfulness of reducing spontaneous mind wandering. PMID:26720411

  11. Increases in the right dorsolateral prefrontal cortex and decreases the rostral prefrontal cortex activation after-8 weeks of focused attention based mindfulness meditation.

    Science.gov (United States)

    Tomasino, Barbara; Fabbro, Franco

    2016-02-01

    Mindfulness meditation is a form of attention control training. The training exercises the ability to repeatedly focus attention. We addressed the activation changes related to an 8-weeks mindfulness-oriented focused attention meditation training on an initially naïve subject cohort. Before and after training participants underwent an fMRI experiment, thus, although not strictly a cross over design, they served as their internal own control. During fMRI they exercised focused attention on breathing and body scan as compared to resting. We found increased and decreased activation in different parts of the prefrontal cortex (PFC) by comparing pre- vs. post-mindfulness training (MT) during breathing and body scan meditation exercises that were compared against their own resting state. In the post-MT (vs. pre-MT) meditation increased activation in the right dorsolateral PFC and in the left caudate/anterior insula and decreased activation in the rostral PFC and right parietal area 3b. Thus a brief mindfulness training caused increased activation in areas involved in sustaining and monitoring the focus of attention (dorsolateral PFC), consistent with the aim of mindfulness that is exercising focused attention mechanisms, and in the left caudate/anterior insula involved in attention and corporeal awareness and decreased activation in areas part of the "default mode" network and is involved in mentalizing (rostral PFC), consistent with the ability trained by mindfulness of reducing spontaneous mind wandering.

  12. Epidemiology, severity classification, and outcome of moderate and severe traumatic brain injury: a prospective multicenter study

    NARCIS (Netherlands)

    Andriessen, T.M.J.C.; Horn, J.; Franschman, G.; Naalt, J. van der; Haitsma, I.; Jacobs, B.; Steyerberg, E.W.; Vos, P.E.

    2011-01-01

    Changes in the demographics, approach, and treatment of traumatic brain injury (TBI) patients require regular evaluation of epidemiological profiles, injury severity classification, and outcomes. This prospective multicenter study provides detailed information on TBI-related variables of 508 moderat

  13. Epidemiology, Severity Classification, and Outcome of Moderate and Severe Traumatic Brain Injury: A Prospective Multicenter Study

    NARCIS (Netherlands)

    T.M.J.C. Andriessen; J. Horn; G. Franschman; J. van der Naalt; I. Haitsma; B. Jacobs; E.W. Steyerberg; P.E. Vos

    2011-01-01

    Changes in the demographics, approach, and treatment of traumatic brain injury (TBI) patients require regular evaluation of epidemiological profiles, injury severity classification, and outcomes. This prospective multicenter study provides detailed information on TBI-related variables of 508 moderat

  14. Epidemiology, Severity Classification, and Outcome of Moderate and Severe Traumatic Brain Injury : A Prospective Multicenter Study

    NARCIS (Netherlands)

    Andriessen, Teuntje M. J. C.; Horn, Janneke; Franschman, Gaby; van der Naalt, Joukje; Haitsma, Iain; Jacobs, Bram; Steyerberg, Ewout W.; Vos, Pieter E.

    2011-01-01

    Changes in the demographics, approach, and treatment of traumatic brain injury (TBI) patients require regular evaluation of epidemiological profiles, injury severity classification, and outcomes. This prospective multicenter study provides detailed information on TBI-related variables of 508 moderat

  15. Family system characteristics and psychological adjustment to cancer susceptibility genetic testing : a prospective study

    NARCIS (Netherlands)

    van Oostrom, I.; Meijers-Heijboer, H.; Duivenvoorden, H. J.; Brocker-Vriends, A. H. J. T.; van Asperen, C. J.; Sijmons, R. H.; Seynaeve, C.; Van Gool, A. R.; Klijn, J. G. M.; Tibben, A.

    2007-01-01

    This study examined prospectively the contribution of family functioning, differentiation to parents, family communication and support from relatives to psychological distress in individuals undergoing genetic susceptibility testing for a known familial pathogenic BRCA1/2 or Hereditary nonpolyposis

  16. Levator hiatal area as a risk factor for cystocele recurrence after surgery: a prospective study

    NARCIS (Netherlands)

    Vergeldt, T.F.; Notten, K.; Weemhoff, M.; Kuijk, S. van; Mulder, F.; Beets-Tan, R.G.; Vliegen, R.; Gondrie, E.; Bergmans, M.; Roovers, J.; Kluivers, K.B.

    2015-01-01

    OBJECTIVE: To investigate whether increased levator hiatal area, measured preoperatively, was independently associated with anatom-ical cystocele recurrence 12 months after anterior colporrhaphy. DESIGN: Multicentre prospective cohort study. SETTING: Nine teaching hospitals in the Netherlands. POPUL

  17. The natural history of adult pulmonary Langerhans cell histiocytosis: a prospective multicentre study

    OpenAIRE

    Tazi, Abdellatif; de Margerie, Constance; Naccache, Jean Marc; Fry, Stéphanie; Dominique, Stéphane; Jouneau, Stéphane; Lorillon, Gwenaël; Bugnet, Emmanuelle; Chiron, Raphael; Wallaert, Benoit; Valeyre, Dominique; Chevret, Sylvie

    2015-01-01

    Background The natural history of pulmonary Langerhans cell histiocytosis (PLCH) has been unclear due to the absence of prospective studies. The rate of patients who experience an early progression of their disease is unknown. Additionally, conflicting effects of smoking cessation on the outcome of PLCH have been reported. Methods In this prospective, multicentre study, 58 consecutive patients with newly diagnosed PLCH were comprehensively evaluated over a two-year period. Our objectives were...

  18. The examination of the effects of 8-week plyometric training on some physical fitness parameters of women handball players aged between 12-16 years old8 haftalık pliometrik antrenmanın 12-16 yaş kadın hentbolcuların bazı fiziksel uygunluk parametrelerine etkisinin incelenmesi

    OpenAIRE

    Ali Ağılönü; Gani Kıratlı

    2015-01-01

    The aim of this study was to examine the impacts of 8-week plyometric exercise on some physical fitness parameters of women handball players aged 12-16 years old. 40 women athletes, 20-subject and 20-control group, participated in the study. While both group participated in the exercises regularly, subject group joined extra plyometric exercises twice a week. Before exercises pretest and posttest were applied.For statistical analysis, Wilcoxon test was used for comparison of intra-group; Mann...

  19. Isokinetic lifting strength and occupational injury. A prospective study.

    Science.gov (United States)

    Mostardi, R A; Noe, D A; Kovacik, M W; Porterfield, J A

    1992-02-01

    One hundred seventy-one nurses had their back strength evaluated on an isokinetic lifting device and filled out an epidemiologic questionnaire. They were then followed prospectively for 2 years to determine the incidence of job-related low-back injuries. The data were analyzed to determine if the injury incidence correlated with any of the strength or epidemiologic variables collected during the original evaluation. Average peak force measured during the isokinetic lift was 63.8 kg + 13.6 kg at a lift speed of 30.5 cm/sec and 59.1 kg + 14.9 kg at a lift speed of 45.7 cm/sec. Sixteen nurses reported an occurrence of job-related low-back pain or injury during the 2-year prospective period. Discriminate statistical techniques showed that none of the strength or epidemiologic variables correlated with the incidence of pain or injury or explained significant amounts of variance when the variables were regressed on strength or work calculated from the lift force/lift height data. It was concluded that in this high risk population, in which loads are heavy and lifting postures are variable, the use of low-back strength or prior history of pain or injury are poor predictors as to subsequent low-back pain or injury. PMID:1532461

  20. Self-rated health and mortality in individuals with diabetes mellitus: prospective cohort study

    OpenAIRE

    Wennberg, Patrik; Rolandsson, Olov; Jerden, Lars; Boeing, Heiner; Sluik, Diewertje; Kaaks, Rudolf; Teucher, Birgit; Spijkerman, Annemieke; de Mesquita, Bas Bueno; Dethlefsen, Claus; Nilsson, Peter; Noethlings, Ute

    2012-01-01

    Objectives: To investigate whether low self-rated health (SRH) is associated with increased mortality in individuals with diabetes. Design: Population-based prospective cohort study. Setting: Enrolment took place between 1992 and 2000 in four centres (Bilthoven, Heidelberg, Potsdam, Umea) in a subcohort nested in the European Prospective Investigation into Cancer and Nutrition. Participants: 3257 individuals (mean +/- SD age was 55.8 +/- 7.6 years and 42% women) with confirmed diagnosis of di...

  1. Does Sexual Victimization Predict Subsequent Alcohol Consumption? A Prospective Study among a Community Sample of Women

    OpenAIRE

    Testa, Maria; Livingston, Jennifer A.; Hoffman, Joseph H.

    2007-01-01

    Although rape and sexual victimization experiences have been hypothesized to contribute to subsequent heavy drinking and alcohol problems among women, little prospective evidence exists. The present prospective study examined whether sexual victimization contributes to subsequent heavy drinking among a community sample of women, 18 – 30 years of age (n = 927). Using three waves of data, 12 months apart, we examined the impact of T1 sexual victimization on T2 heavy drinking, and of T2 sexual v...

  2. The Examining of Prospective Teachers? Views about Renewable and Non-Renewable Energy Sources: A Case Study of Turkey

    Science.gov (United States)

    Hasiloglu, Mehmet Akif

    2014-01-01

    The aim of this study is to determine prospective teachers? views about renewable and non-renewable energy sources. To collect data, a questionnaire with 5 open-ended questions was conveyed to 463 prospective teachers selected from Agri Ibrahim Cecen University. The results showed that almost three fourths of the prospective teachers tend to…

  3. The WISTAH hand study: A prospective cohort study of distal upper extremity musculoskeletal disorders

    Directory of Open Access Journals (Sweden)

    Garg Arun

    2012-06-01

    Full Text Available Abstract Background Few prospective cohort studies of distal upper extremity musculoskeletal disorders have been performed. Past studies have provided somewhat conflicting evidence for occupational risk factors and have largely reported data without adjustments for many personal and psychosocial factors. Methods/design A multi-center prospective cohort study was incepted to quantify risk factors for distal upper extremity musculoskeletal disorders and potentially develop improved methods for analyzing jobs. Disorders to analyze included carpal tunnel syndrome, lateral epicondylalgia, medial epicondylalgia, trigger digit, deQuervain’s stenosing tenosynovitis and other tendinoses. Workers have thus far been enrolled from 17 different employment settings in 3 diverse US states and performed widely varying work. At baseline, workers undergo laptop administered questionnaires, structured interviews, two standardized physical examinations and nerve conduction studies to ascertain demographic, medical history, psychosocial factors and current musculoskeletal disorders. All workers’ jobs are individually measured for physical factors and are videotaped. Workers are followed monthly for the development of musculoskeletal disorders. Repeat nerve conduction studies are performed for those with symptoms of tingling and numbness in the prior six months. Changes in jobs necessitate re-measure and re-videotaping of job physical factors. Case definitions have been established. Point prevalence of carpal tunnel syndrome is a combination of paraesthesias in at least two median nerve-served digits plus an abnormal nerve conduction study at baseline. The lifetime cumulative incidence of carpal tunnel syndrome will also include those with a past history of carpal tunnel syndrome. Incident cases will exclude those with either a past history or prevalent cases at baseline. Statistical methods planned include survival analyses and logistic regression. Discussion A

  4. Orthodontics as a prospective career choice among undergraduate dental students: A prospective study

    OpenAIRE

    Sam, George

    2015-01-01

    Objectives: The purposes of this study were to investigate the factors influencing the career choice of dental students and to identify the future life plans of the students at Prince Sattam Bin Abdulaziz University Dental College who had chosen orthodontics as their future specialty. Materials and Methods: An epidemiological descriptive survey was conducted using a set of questionnaire among the second year to fourth year students at Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Ar...

  5. The Effects of Simultaneous 8 Weeks Astragalus sp/ Euphorbia Cheriradenia Honey Supplementation and Endurance Training on Membrane Lipid Peroxidation of Erythrocytes after a Bout Acute Exhaustive Treadmill Exercise in Rats

    Directory of Open Access Journals (Sweden)

    BIJAN GOODARZI

    2013-05-01

    Full Text Available Strenuous exercise is known to induce oxidative stress leading to the generation of free radicals. The purpose of the present study was to investigate the effects of honey, at a dose (1.5 g/kg weight per d on the MDA and SOD levels of plasma in rats after exhaustive exercise. Male rats (n=48 were divided into four groups, group 1, sedentary with distilled water (Sed -DW n=12, group 2, sedentary control with honey (Sed-H N=12, group 3, exercise trained with distilled water (ET-WD n=12, group 4, exercise trained with honey (ET- H n=12 groups. Four groups were further divided equally into two groups where the rats were studied at rest and immediately after exhaustive exercise. During the training period, groups 2‚4 were treated with 1.5 g/kg body weight honey, freshly diluted by distilled water to 50% and the other groups 1‚3 were treated with distilled water (1 ml just before each administration intragastrically tube daily at 8:00 to rats / once daily for 8 weeks. Endurance training consisted of treadmill running 1.5 h day-1, 5 days a week for 8 weeks, reaching the speed of 2.1 kmh-1at the fourth week. For acute exhaustive exercise, graded treadmill running was conducted reaching the speed of 2.1 km h-1 at the 95th min, 10% uphill, and was continued until exhaustion. Erythrocyte MDA level was significantly increased after exhaustion in groups 1‚3 but not in groups 2‚4 animals compared with the corresponding sedentary rest. Honey treatment caused a significant decrease in MDA levels of groups 2‚ 4 compared to the groups 1‚ 3 animals. While acute exhaustive exercise decreased erythrocyte SOD activity in subgroups 1‚ 3 rats, it increased the activity of this enzyme in groups 2‚ 4 rats. Treadmill training increased the endurance time in trained rats compared with sedentary rats. The results of this study suggest that honey supplementation may be useful to prevent acute exhaustive exercise-induced oxidative stress in erythrocytes by up

  6. A Prospecting Mineralogy Study:Arsenopyrite In Endogenetic Gold Deposits

    Institute of Scientific and Technical Information of China (English)

    LI Xiaomin; ZHANG Hongzhi

    2001-01-01

    Arsenopyrite is one of very important and common auriferous minerals in endogenetic gold deposits. In seven gold deposits, the prospecting typomorphic characteristics of arsenopyrite, such as morphological typomorphism, composition typomorphism, pyroelectricity typomorphism and so on, were established. The crystal form of arsenopyrite is simple, and the form symbols mainly are {101}, {120}, {210}, {140}, {230}, {012}, etc. The smaller groin and poor crystal form arsenopyrite indicates the better auriferous characteristics. The major elements (Fe, As and S) of gold- bearing arsenopyrite usually show Fe/As + S > 0.5, As/S< 1 which deviates from its theoretical value. The most important trace element is Au and next is Ag in arsenopyrite, and they often show the positive correlation. The pyroelectricity of arsenopyrite can reflect the mineralization epoch, and it also is related to the crystal form and granudarity.

  7. Intracranial hypotension accompanied by trauma. A prospective study in Japan

    International Nuclear Information System (INIS)

    To clarify the clinical characteristics of definite and non-definite diagnosis groups in intracranial hypotension accompanied by trauma (IHAT), we undertook investigations of registered patients (n=23) prospectively. The results revealed the following features of IHAT: definite diagnosis group, 4 cases; they had long periods from injury to onset (5.5±5.7 days), but these were markedly shorter than in the non-definite group; 75% of definite cases showed typical postural headache; 75% of definite cases showed dural enhancement on Gd-MRI; all 4 cases had confirmed cerebrospinal fluid (CFS) leakage based on imaging diagnosis with cervical lesions in 2 cases and cervical-thoracic lesions in 2 cases; and 6) good recovery was achieved in them by conservative therapy and blood patch, with a cure rate of 100%. These findings suggest that confirmed CFS leakage is indispensable for reaching definite diagnosis of IHAT. (author)

  8. Fatty liver: prospective comparative study with sonography and CT

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung Jin; Kim, Y. M.; Kim, W. S.; Choi, B. I.; Lee, J. S.; Han, C. K.; Kim, C. W. [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1990-12-15

    To identify the reasonable criteria in detection of the degree of Fatty liver, we prospectively evaluated sonograms and CT scans in 33 Patients With bright liver on sonography. On sonograms, we analyzed the echogenicity of the liver, acoustic attenuation, and visualization of the portal vein and the diaphragm, Each criterion was scored from 0 to 2. CT criterion for fatty liver was assessed by the attenuation difference between the liver and the spleen on nonocontrast CT scans, The average sonographic grade for CT Grade I was 1.3, Grade II was 2.1,and Grade III was 2.8. The accurate detection rate of each sonographic grade was as follows, Grade

  9. Cohort profile: golestan hepatitis B cohort study- a prospective long term study in northern iran ​.

    Science.gov (United States)

    Poustchi, Hossein; Katoonizadeh, Aezam; Ostovaneh, Mohammad Reza; Moossavi, Shirin; Sharafkhah, Maryam; Esmaili, Saeed; Pourshams, Akram; Mohamadkhani, Ashraf; Besharat, Sima; Merat, Shahin; Mohamadnejad, Mehdi; George, Jacob; Malekzadeh, Reza

    2014-10-01

    Hepatitis B virus (HBV) infection is the most common cause of end stage liver disease in Iran and in Golestan province. Large-scale population-based prospective cohort studies with long term follow-up are the method of choice to accurately understand the natural course of HBV infection. To date, several studies of HBV epidemiology, natural history, progression to cirrhosis and association with HCC have been reported from other countries. However, few of these are prospective and fewer still are population-based. Moreover, the underlying molecular mechanisms and immunogenetic determinants of the outcome of HBV infection especially in low and middle income countries remains largely unknown. Therefore, the hepatitis B cohort study (HBCS), nested as part of the Golestan Cohort Study (GCS), Golestan, Iran was established in 2008 with the objective to prospectively investigate the natural course of chronic hepatitis B with reference to its epidemiology, viral/host genetic interactions, clinical features and outcome in the Middle East where genotype D HBV accounts for >90% of infections. In 2008, a baseline measurement of HBV surface antigen (HBsAg) was performed on stored serum samples of all GCS participants. A sub-cohort of 3,505 individuals were found to be HBsAg positive and were enrolled in the Golestan HBCS. In 2011, all first degree relatives of HBsAg positive subjects including their children and spouses were invited for HBV serology screening and those who were positive for HBsAg were also included in the Golestan HBCS. PMID:25349681

  10. Lacerations in urban children. A prospective 12-January study.

    Science.gov (United States)

    Baker, M D; Selbst, S M; Lanuti, M

    1990-01-01

    We prospectively investigated the epidemiologic characteristics of all lacerations (N = 2834) repaired at the Children's Hospital of Philadelphia (Pa) during 1987 and identified common hazards and possible avenues of intervention. Two-year-old children incurred most injuries; males outnumbered females 2:1. Almost two thirds (61.8%) of all lacerations occurred from May through September, and 62.2% between 3 and 9 PM. Most injuries occurred indoors (47.0%), on the sidewalk or street (22.5%), or in the residential yard (13.0%). Injuries usually occurred during play (42.3%) or daily activity (32.1%); 1247 (44.0%) involved some sort of fall. Vectors most frequently causing injury were broken glass bottles (15.0%), wooden furniture (12.0%), and asphalt or concrete (11.0%). Broken glass bottles also most frequently inflicted injuries resulting in functional impairment (0.2%), hospitalization (0.9%), or both. Complications were seen in 8% of all lacerations. Our data confirm the importance of injury-prevention strategies aimed at reduction of discarded glass objects (ie, recycling legislation), improved furniture design, and improved municipal services (ie, street repair).

  11. AN OVERVIEW OF SINONASAL POLYPOSIS: A PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Kabikanta

    2016-03-01

    Full Text Available INTRODUCTION Sinonasal polyposis, one of the most common inflammatory mass lesions of the nose affecting up to 40% of the population. They present with nasal obstruction, anosmia, rhinorrhoea, post-nasal drip, and less commonly headache. Their aetiology remains unclear, but they are known to have associations with allergy, asthma, infection, fungus, cystic fibrosis, and aspirin sensitivity. Strong genetic factors are implicated in the pathogenesis of SNP, but genetic and molecular alterations required for its development and progression are still unclear. Management of SNP involves a combination of conservative treatment and surgical treatment. There is good evidence for the use of corticosteroids (systematic and topical, both as primary treatment and as postoperative prophylaxis against recurrence, but the prolonged course of the disease and adverse effect of systematic steroid limits their use. Surgical treatment has been refined significantly over the past 20 years with the advent of endoscopic sinus surgery and, in general, is reserved for cases refractory to medical treatment. Recurrence of the polyposis is common with severe disease recurring in up to 10% of patients. Over the last two decades, increasing insights in the pathophysiology of nasal polyposis opens prospective for new pharmacological treatment options, with eosinophilic inflammation, IgE, fungi and staphylococcus aureus as potential targets. A better understanding of the pathophysiology underlying the persistent inflammatory state in SNP is necessary to ultimately develop novel pharmacotherapeutic approaches. Here, we present the newer treatment options available for better control and possibly cure of the disease.

  12. 8周正念训练对负性情绪的改善效果%Effectiveness of 8-week mindfulness training improving negative emotions

    Institute of Scientific and Technical Information of China (English)

    徐慰; 王玉正; 刘兴华

    2015-01-01

    目的:考察正念训练改善负性情绪的效果以及正念水平提升对干预效果的中介作用。方法:采用随机对照实验设计。通过讲座的方式招募存在压力、负性情绪并愿意通过正念训练来缓解的个体参与研究,共招募90人,将其随机分为正念训练组与等待对照组。其中79人完成研究(正念训练组38人,等待对照组41人)。正念训练组参加8周正念训练,在此期间等待对照组不进行干预。采用五因素正念度量表(FFMQ)测量正念水平,简明心境量表(POMS)测量情绪。结果:8周训练后,正念训练组FFMQ总分高于基线[(125.9±11.9)vs.(121.2±12.5),P<0.01],POMS负性情绪总分及紧张焦虑、抑郁沮丧、疲劳维度得分均低于基线(均P<0.01);而对照组各项得分与基线差异均无统计学意义(均 P>0.05)。FFMQ总分的增加对干预所造成的POMS中负性情绪总分(95%CI=-6.24~-0.74)及紧张-焦虑(95%CI=-1.65~-0.12)、抑郁-沮丧(95%CI=-1.63~-0.14)、疲劳(95%CI=-1.72~-0.20)的减少存在中介作用。结论:正念训练可以有效改善参与者的负性情绪,正念水平的提升是干预造成情绪缓解的重要因素。%Objective:To investigate the effectiveness of mindfulness training improving negative emotions, furthering to explore the mediating effect of the improvement of mindfulness levels for the training effects.Methods:Randomized control trail was used in this research.Ninety participants who suffered negative e-motions and resolved to alleviate stress by mindfulness training were recruited by lecture.They were randomized in-to mindfulness training group or waitlist control group,and 79 of them completed the intervention (38 in mindful-ness training group and 41 in waitlist control group).Participants in mindfulness training group received an 8-week mindfulness training

  13. Effects of trans- and n-3 unsaturated fatty acids on cardiovascular risk markers in healthy males. An 8 weeks dietary intervention study

    DEFF Research Database (Denmark)

    Dyerberg, J; Eskesen, D C; Andersen, P W;

    2004-01-01

    of dietary enrichment with TFA or n-3 PUFA. DESIGN: Randomized, double-blind, parallel intervention trial. SETTING: Department of Human Nutrition, The Royal Veterinary and Agricultural University. SUBJECTS: In all, 87 healthy males included, 79 completed. INTERVENTION: Subjects were randomly assigned to 8...... pressure, heart rate variability (HRV), arterial dilatory capacity, compliance, and distensibility were recorded before and after intervention and at follow-up 12 weeks after the intervention. RESULTS: High-density lipoprotein cholesterol (HDL-C) decreased in the TFA group and triglycerides and mean...

  14. Prospective research on musculoskeletal disorders in office workers (PROMO) : Study protocol

    NARCIS (Netherlands)

    IJmker, S.; Blatter, B.M.; Beek, A.J. van der; Mechelen, W. van; Bongers, P.M.

    2006-01-01

    Background: This article describes the background and study design of the PROMO study (Prospective Research on Musculoskeletal disorders in Office workers). Few longitudinal studies have been performed to investigate the risk factors responsible for the incidence of hand, arm, shoulder and neck symp

  15. Decision Making and Response Inhibition as Predictors of Heavy Alcohol Use: A Prospective Study

    NARCIS (Netherlands)

    A.E. Goudriaan; E.R. Grekin; K.J. Sher

    2011-01-01

    Background: Very few studies have investigated the "real world" prospective, predictive value of behavioral instruments used in laboratory studies to test decision-making abilities or impulse control. The current study examines the degree to which 2 commonly used decision-making/impulse control meas

  16. Salt intake, cured meat consumption, refrigerator use and stomach cancer incidence: A prospective cohort study (Netherlands)

    NARCIS (Netherlands)

    Brandt, P.A. van den; Botterweck, A.A.M.; Goldbohm, R.A.

    2003-01-01

    Objective: Many case-control studies have reported that salt and cured meat intake are positively, and refrigerator use is inversely, associated with stomach cancer risk. In the current prospective study these associations were evaluated. Methods: The Netherlands Cohort Study consisted of 120,852 me

  17. Assessment of the effect of esterified propoxylated glycerol (EPG) on the status of fat-soluble vitamins and select water-soluble nutrients following dietary administration to humans for 8 weeks.

    Science.gov (United States)

    Davidson, Michael H; Bechtel, David H

    2014-12-01

    This double-blind, randomized, controlled study assessed the effect of esterified propoxylated glycerol (EPG) on fat-soluble vitamins and select nutrients in human subjects. For 8 weeks, 139 healthy volunteers consumed a core diet providing adequate caloric and nutrient intakes. The diet included items (spread, muffins, cookies, and biscuits) providing EPG (10, 25, and 40 g/day) vs. margarine alone (control). EPG did not significantly affect circulating retinol, α-tocopherol, or 25-OH D2, but circulating β-carotene and phylloquinone were lower in the EPG groups, and PIVKA-II levels were higher; 25-OH D3 increased but to a lesser extent than the control. The effect might be related to EPG acting as a lipid "sink" during gastrointestinal transit. No effects were seen in secondary endpoint measures (physical exam, clinical pathology, serum folate, RBC folate, vitamin B12, zinc, iron, calcium, phosphorus, osteocalcin, RBP, intact PTH, PT, PTT, cholesterol, HDL-C, LDL-C, triglycerides). Gastrointestinal adverse events (gas with discharge; diarrhea; oily spotting; oily evacuation; oily stool; liquid stool; soft stool) were reported more frequently by subjects receiving 25 or 40 g/day of EPG. In general, the incidence and duration of these symptoms correlated directly with EPG dietary concentration. The results suggest 10 g/day of EPG was reasonably well tolerated.

  18. Assessment of the effect of esterified propoxylated glycerol (EPG) on the status of fat-soluble vitamins and select water-soluble nutrients following dietary administration to humans for 8 weeks.

    Science.gov (United States)

    Davidson, Michael H; Bechtel, David H

    2014-12-01

    This double-blind, randomized, controlled study assessed the effect of esterified propoxylated glycerol (EPG) on fat-soluble vitamins and select nutrients in human subjects. For 8 weeks, 139 healthy volunteers consumed a core diet providing adequate caloric and nutrient intakes. The diet included items (spread, muffins, cookies, and biscuits) providing EPG (10, 25, and 40 g/day) vs. margarine alone (control). EPG did not significantly affect circulating retinol, α-tocopherol, or 25-OH D2, but circulating β-carotene and phylloquinone were lower in the EPG groups, and PIVKA-II levels were higher; 25-OH D3 increased but to a lesser extent than the control. The effect might be related to EPG acting as a lipid "sink" during gastrointestinal transit. No effects were seen in secondary endpoint measures (physical exam, clinical pathology, serum folate, RBC folate, vitamin B12, zinc, iron, calcium, phosphorus, osteocalcin, RBP, intact PTH, PT, PTT, cholesterol, HDL-C, LDL-C, triglycerides). Gastrointestinal adverse events (gas with discharge; diarrhea; oily spotting; oily evacuation; oily stool; liquid stool; soft stool) were reported more frequently by subjects receiving 25 or 40 g/day of EPG. In general, the incidence and duration of these symptoms correlated directly with EPG dietary concentration. The results suggest 10 g/day of EPG was reasonably well tolerated. PMID:25497998

  19. A prospective cohort study of the effects of adjuvant breast cancer chemotherapy on taste function, food liking, appetite and associated nutritional outcomes.

    Directory of Open Access Journals (Sweden)

    Anna Boltong

    Full Text Available 'Taste' changes are commonly reported during chemotherapy. It is unclear to what extent this relates to actual changes in taste function or to changes in appetite and food liking and how these changes affect dietary intake and nutritional status.This prospective, repeated measures cohort study recruited participants from three oncology clinics. Women (n = 52 prescribed adjuvant chemotherapy underwent standardised testing of taste perception, appetite and food liking at six time points to measure change from baseline. Associations between taste and hedonic changes and nutritional outcomes were examined.Taste function was significantly reduced early in chemotherapy cycles (p<0.05 but showed recovery by late in the cycle. Ability to correctly identify salty, sour and umami tastants was reduced. Liking of sweet food decreased early and mid-cycle (p<0.01 but not late cycle. Liking of savory food was not significantly affected. Appetite decreased early in the cycle (p<0.001. Reduced taste function was associated with lowest kilojoule intake (r = 0.31; p = 0.008 as was appetite loss with reduced kilojoule (r = 0.34; p = 0.002 and protein intake (r = 0.36; p = 0.001 early in the third chemotherapy cycle. Decreased appetite early in the third and final chemotherapy cycles was associated with a decline in BMI (p = <0.0005 over the study period. Resolution of taste function, food liking and appetite was observed 8 weeks after chemotherapy completion. There was no association between taste change and dry mouth, oral mucositis or nausea.The results reveal, for the first time, the cyclical yet transient effects of adjuvant chemotherapy on taste function and the link between taste and hedonic changes, dietary intake and nutritional outcomes. The results should be used to inform reliable pre-chemotherapy education.

  20. Hyperbilirubinemia after extracorporeal circulation surgery: A recent and prospective study

    Institute of Scientific and Technical Information of China (English)

    Yong An; Ying-Bin Xiao; Qian-Jin Zhong

    2006-01-01

    AIM: To clarify the incidence and nature of postoperative hyperbilirubinemia in patients after modern extracorporeal circulation, to analyze possible perioperative risk factors, and to elucidate the clinical significance of postoperative hyperbilirubinemia associated morality and morbidity.METHODS: Between March 2005 and May 2006, three hundred and eighty six consecutive patients undergoing extracorporeal circulation surgery due to a variety of cardiac lesions were investigated prospectively. The incidence of postoperative hyperbilirubinemia was defined as a serum total bilirubin concentration of more than 51 μmol/L. Several perioperative parameters were compared by logistic regression between hyperbilirubinemia and non-hyperbilirubinemia patients to determine possible risk factors contributing to postoperative hyperbilirubinemia and mortality.RESULTS: Overall incidence of postoperative hyperbilirubinemia was 25.3% (98/386). In patients with postoperative hyperbilirubinemia, 56.2%reached peak total bilirubin concentration on the first postoperative day, 33.5% on the second day, and 10.3%on the seventh day. Eighty percent of the increase of total bilirubin resulted from an increase of both conjugated and unconjugated bilirubin. Development of postoperative hyperbilirubinemia was associated with a higher mortality (P < 0.01), longer duration of mechanical ventilation (P < 0.05) and longer ICU stay time (P < 0.05). Preoperative total bilirubin concentration, preoperative right atrium pressure,numbers of valves replaced and of blood transfusion requirement were identified as important predictors for postoperative hyperbilirubinemia.CONCLUSION: Early postoperative hyperbilirubinemia after modern extracorporeal circulation is mainly caused by an increase in both conjugated and unconjugated bilirubin, and is associated with a high mortality.Important contributing factors are the preoperative total bilirubin concentration, preoperative severity of right atrial

  1. Toward Fully Automated Multicriterial Plan Generation: A Prospective Clinical Study

    Energy Technology Data Exchange (ETDEWEB)

    Voet, Peter W.J., E-mail: p.voet@erasmusmc.nl [Department of Radiation Oncology, Erasmus Medical Center–Daniel den Hoed Cancer Center, Groene Hilledijk 301, Rotterdam 3075EA (Netherlands); Dirkx, Maarten L.P.; Breedveld, Sebastiaan; Fransen, Dennie; Levendag, Peter C.; Heijmen, Ben J.M. [Department of Radiation Oncology, Erasmus Medical Center–Daniel den Hoed Cancer Center, Groene Hilledijk 301, Rotterdam 3075EA (Netherlands)

    2013-03-01

    Purpose: To prospectively compare plans generated with iCycle, an in-house-developed algorithm for fully automated multicriterial intensity modulated radiation therapy (IMRT) beam profile and beam orientation optimization, with plans manually generated by dosimetrists using the clinical treatment planning system. Methods and Materials: For 20 randomly selected head-and-neck cancer patients with various tumor locations (of whom 13 received sequential boost treatments), we offered the treating physician the choice between an automatically generated iCycle plan and a manually optimized plan using standard clinical procedures. Although iCycle used a fixed “wish list” with hard constraints and prioritized objectives, the dosimetrists manually selected the beam configuration and fine tuned the constraints and objectives for each IMRT plan. Dosimetrists were not informed in advance whether a competing iCycle plan was made. The 2 plans were simultaneously presented to the physician, who then selected the plan to be used for treatment. For the patient group, differences in planning target volume coverage and sparing of critical tissues were quantified. Results: In 32 of 33 plan comparisons, the physician selected the iCycle plan for treatment. This highly consistent preference for the automatically generated plans was mainly caused by the improved sparing for the large majority of critical structures. With iCycle, the normal tissue complication probabilities for the parotid and submandibular glands were reduced by 2.4% ± 4.9% (maximum, 18.5%, P=.001) and 6.5% ± 8.3% (maximum, 27%, P=.005), respectively. The reduction in the mean oral cavity dose was 2.8 ± 2.8 Gy (maximum, 8.1 Gy, P=.005). For the swallowing muscles, the esophagus and larynx, the mean dose reduction was 3.3 ± 1.1 Gy (maximum, 9.2 Gy, P<.001). For 15 of the 20 patients, target coverage was also improved. Conclusions: In 97% of cases, automatically generated plans were selected for treatment because of

  2. Prospective study of serum uric acid and risk of brain infarction

    Institute of Scientific and Technical Information of China (English)

    孟令民

    2014-01-01

    Objective To prospectively investigate the association between serum uric acid concentration and the risk of brain infarction in Chinese adults.Methods In this prospective cohort study,a total of 95 738 participants(aged 18-98 years old)were included and were categorized into sex-specific quintiles according to serum uric acid concentration which were collected during 2006—2007 by health examinations.The study was followed up for an average of 4 years.We used Cox regression models to

  3. Testosterone deficiency and quality of life in Australasian testicular cancer survivors: a prospective cohort study.

    Science.gov (United States)

    O'Carrigan, B; Fournier, M; Olver, I N; Stockler, M R; Whitford, H; Toner, G C; Thomson, D B; Davis, I D; Hanning, F; Singhal, N; Underhill, C; Clingan, P; McDonald, A; Boland, A; Grimison, P

    2014-08-01

    This is the first prospective study in a contemporary Australian/New Zealand population to determine the prevalence of testosterone deficiency in testicular cancer survivors at 12 months from treatment, and any association with poorer quality of life. Hormone assays from 54 evaluable patients in a prospective cohort study revealed biochemical hypogonadism in 18 patients (33%) and low-normal testosterone in 13 patients (24%). We found no association between testosterone levels and quality of life (all P > 0.05). Hypogonadal patients should be considered for testosterone replacement to prevent long-term morbidity. PMID:25081047

  4. Symptoms, treatment and "dying peacefully" in terminally ill cancer patients: a prospective study

    NARCIS (Netherlands)

    Georges, J.J.; Philipsen, B.D.; Heide, van der A.; Wal, van der G.; Maas, van der P.J.

    2005-01-01

    GOALS: The aims of this study were to describe the symptoms, their treatment during the final months of life of terminally ill cancer patients and to assess characteristics of the dying process. PATIENTS AND METHODS: We used a prospective study design. From a representative sample of physicians who

  5. The price of donation after cardiac death in liver transplantation : a prospective cost-effectiveness study

    NARCIS (Netherlands)

    van der Hilst, Christian S.; IJtsma, Alexander J. C.; Bottema, Jan T.; van Hoek, Bart; Dubbeld, Jeroen; Metselaar, Herold J.; Kazemier, Geert; van den Berg, Aad P.; Porte, Robert J.; Slooff, Maarten J. H.

    2013-01-01

    This study aims to perform a detailed prospective observational multicenter cost-effectiveness study by comparing liver transplantations with Donation after Brain Death (DBD) and Donation after Cardiac Death (DCD) grafts. All liver transplantations in the three Dutch liver transplant centers between

  6. Asthma and Attention-Deficit/Hyperactivity Disorder: A Nationwide Population-Based Prospective Cohort Study

    Science.gov (United States)

    Chen, Mu-Hong; Su, Tung-Ping; Chen, Ying-Sheue; Hsu, Ju-Wei; Huang, Kai-Lin; Chang, Wen-Han; Chen, Tzeng-Ji; Bai, Ya-Mei

    2013-01-01

    Background: Previous cross-sectional studies have suggested an association between asthma and attention-deficit/hyperactivity disorder (ADHD), but the temporal relationship was not determined. Using a nationwide population-based prospective case-control cohort study (1:4, age-/gender-matched), we hypothesized that asthma in infanthood or early…

  7. Progression of hepatic fibrosis in patients with hepatitis C: a prospective repeat liver biopsy study

    OpenAIRE

    Ryder, S. D.

    2004-01-01

    Background: The natural history of hepatitis C virus (HCV) infection remains uncertain. Previous data concerning rates of progression are from studies using estimated dates of infection and single liver biopsy scores. We prospectively studied the rate of progression of fibrosis in HCV infected patients by repeat liver biopsies without intervening treatment.

  8. Prenatal, Perinatal, and Neonatal Risk Factors for Specific Language Impairment: A Prospective Pregnancy Cohort Study

    Science.gov (United States)

    Whitehouse, Andrew J. O.; Shelton, W. M. R.; Ing, Caleb; Newnham, John P.

    2014-01-01

    Purpose: Although genetic factors are known to play a causal role in specific language impairment (SLI), environmental factors may also be important. This study examined whether there are prenatal, perinatal, and neonatal factors that are associated with childhood SLI. Method: Participants were members of the Raine Study, a prospective cohort…

  9. Sleep disturbances and fatigue : independent predictors of sickness absence? A prospective study among 6538 employees

    NARCIS (Netherlands)

    Bultmann, Ute; Nielsen, Maj Britt D.; Madsen, Ida E. H.; Burr, Hermann; Rugulies, Reiner

    2013-01-01

    Background: Although sleep disturbances and fatigue are common conditions, frequently shown to be associated with sickness absence, only a few studies have prospectively investigated their independent effects on sickness absence, while adjusting for depressive symptoms. This study aims (i) to examin

  10. A prospective study on cortisol, dehydroepiandrosterone sulfate, and cognitive function in the elderly

    NARCIS (Netherlands)

    Kalmijn, S; Launer, LJ; Stolk, RP; de Jong, FH; Pols, HAP; Hofman, A; Breteler, MMB; Lamberts, SWJ

    1998-01-01

    The objective of this study was to investigate the relation between the peripheral concentrations of the adrenal steroid hormones cortisol and dehydroepiandrosterone sulfate (DHEAS) and cognitive impairment and decline. A prospective study design was used. The setting was a suburb of Rotterdam, The

  11. Pre-diagnostic alcohol consumption and postmenopausal breast cancer survival: a prospective patient cohort study

    NARCIS (Netherlands)

    Vrieling, A.; Buck, K.; Heinz, J.; Obi, N.; Benner, A.; Flesch-Janys, D.; Chang-Claude, J.

    2012-01-01

    Study results on the association of alcohol consumption with breast cancer survival are inconsistent, partly due to the use of different survival outcomes. We assessed the association of pre-diagnostic alcohol consumption with survival and recurrence in a prospective cohort study in Germany includin

  12. The Intergenerational Continuity of Observed Early Parenting: A Prospective, Longitudinal Study

    Science.gov (United States)

    Kovan, Nikki M.; Chung, Alissa L.; Sroufe, L. Alan

    2009-01-01

    The authors report the results from a prospective, longitudinal study of cross-generational parenting quality in a lower socioeconomic status sample of moderate ethnic diversity (N = 61). The study extends previous research on intergenerational continuity of parenting in several significant ways: (a) Assessments in both generations were based on…

  13. Sustained Effects of Ecstasy on the Human Brain: A Prospective Neuroimaging Study in Novel Users

    Science.gov (United States)

    de Win, Maartje M. L.; Jager, Gerry; Booij, Jan; Reneman, Liesbeth; Schilt, Thelma; Lavini, Christina; Olabarriaga, Silvia D.; den Heeten, Gerard J.; van den Brink, Wim

    2008-01-01

    Previous studies have suggested toxic effects of recreational ecstasy use on the serotonin system of the brain. However, it cannot be excluded that observed differences between users and non-users are the cause rather than the consequence of ecstasy use. As part of the Netherlands XTC Toxicity (NeXT) study, we prospectively assessed sustained…

  14. Prospective Study on Physical Activity and Risk of In Situ Breast Cancer

    NARCIS (Netherlands)

    Steindorf, Karen; Ritte, Rebecca; Tjonneland, Anne; Johnsen, Nina Fons; Overvad, Kim; Ostergaard, Jane Nautrup; Clavel-Chapelon, Francoise; Fournier, Agnes; Dossus, Laure; Lukanova, Annekatrin; Chang-Claude, Jenny; Boeing, Heiner; Wientzek, Angelika; Trichopoulou, Antonia; Karapetyan, Tina; Trichopoulos, Dimitrios; Masala, Giovanna; Krogh, Vittorio; Mattiello, Amalia; Tumino, Rosario; Polidoro, Silvia; Ramon Quiros, Jose; Travier, Noemie; Sanchez, Maria-Jose; Navarro, Carmen; Ardanaz, Eva; Amiano, Pilar; Bueno-de-Mesguita, H. Bas; van Duijnhoven, Franzel J. B.; Monninkhof, Evelyn; May, Anne M.; Khaw, Kay-Tee; Wareham, Nick; Key, Tim J.; Travis, Ruth C.; Borch, Kristin Benjaminsen; Fedirko, Veronika; Rinaldi, Sabina; Romieu, Isabelle; Wark, Petra A.; Norat, Teresa; Riboli, Elio; Kaaks, Rudolf

    2012-01-01

    Background: Physical activity has been identified as protective factor for invasive breast cancer risk, whereas comparable studies on in situ carcinoma are rare. Methods: The study included data from 283,827 women of the multinational European Prospective Investigation into C7ancer and Nutrition (EP

  15. Prospective study on physical activity and risk of in situ breast cancer

    NARCIS (Netherlands)

    Steindorf, K.; Ritte, R.; Tjonneland, A.; Johnsen, N.F.; Overvad, K.; Ostergaard, J.N.; Boeing, H.; Trichopoulou, A.; Bueno de Mesquita, H.B.; Duijnhoven, van F.J.B.; Monninkhof, E.M.; Khaw, K.T.; Wareham, N.J.; Wark, P.A.; Riboli, E.; Kaaks, R.

    2012-01-01

    Background: Physical activity has been identified as protective factor for invasive breast cancer risk, whereas comparable studies on in situ carcinoma are rare. Methods: The study included data from 283,827 women of the multinational European Prospective Investigation into C7ancer and Nutrition (EP

  16. Susceptibility to deterioration of mobility long-term after stroke: a prospective cohort study.

    NARCIS (Netherlands)

    Port, I.G. van de; Kwakkel, G.; Wijk, I. van; Lindeman, E.

    2006-01-01

    BACKGROUND AND PURPOSE: The aim of the present study was to identify clinical determinants able to predict which individuals are susceptible to deterioration of mobility from 1 to 3 years after stroke. METHODS: Prospective cohort study of stroke patients consecutively admitted for inpatient rehabili

  17. Program specific admission testing and dropout for sports science students: a prospective cohort study

    DEFF Research Database (Denmark)

    O'Neill, Lotte; Christensen, Mette Krogh; Vonsild, Maria Cecilie;

    2014-01-01

    if admission strategy was also independently associated with dropout for sports science students in a university setting. The study design was a prospective cohort study with a 2 year follow-up. The population was 449 sports science students admitted to a university in the years 2002-2007. The analysis...

  18. Predictive factors of postpartum fatigue: a prospective cohort study among working women

    NARCIS (Netherlands)

    Bakker, M.; Beek, A.J. van der; Hendriksen, I.J.M.; Bruinvels, D.J.; Poppel, M.N. van

    2014-01-01

    Objectives The aim of this study was to investigate which prepartum determinants contribute to the development of postpartum (PP) fatigue among working women in the Netherlands. Methods A prospective cohort study in 15 Dutch companies was conducted to measure different potential predictors using sel

  19. Prediction of Participation and Sensory Modulation of Late Preterm Infants at 12 Months: A Prospective Study

    Science.gov (United States)

    Bart, O.; Shayevits, S.; Gabis, L. V.; Morag, I.

    2011-01-01

    The aim of the study was to prospectively assess the differences in participation and sensory modulation between late preterm infants (LPI) and term babies, and to predict it by LPI characteristics. The study population includes 124 late preterm infants at gestational age between 34 and 35 6/7 weeks who were born at the same medical center. The…

  20. Depression in older people after fall-related injuries: a prospective study

    NARCIS (Netherlands)

    Scaf-Klomp, W.; Sanderman, R.; Ormel, J.; Kempen, G.I J M

    2003-01-01

    Background: objectives of the study were i) to describe changes in depression in independently living people aged 57 or older with fall-related injuries, and ii) to examine the effect of incomplete recovery of physical functions on depression one year post-injury. Method: prospective cohort-study, i

  1. Ultrasonic root-end preparation in apical surgery : a prospective randomized study

    NARCIS (Netherlands)

    de Lange, Jan; Putters, Thomas; Baas, Erik M.; van Ingen, Johan M.

    2007-01-01

    Objective. The purpose of this study was to evaluate the potential benefit of an ultrasonic device in apical surgery on the outcome of treatment. Study design. A randomized prospective design was used in a standardized treatment protocol. Patients were allocated to treatment with an ultrasonic devic

  2. Trait Anger, Anger Expression, and Suicide Attempts among Adolescents and Young Adults: A Prospective Study

    Science.gov (United States)

    Daniel, Stephanie S.; Goldston, David B.; Erkanli, Alaattin; Franklin, Joseph C.; Mayfield, Andrew M.

    2009-01-01

    Previous studies of the relationship between anger, anger expression, and suicidal behavior have been largely cross-sectional and have yielded mixed findings. In a prospective, naturalistic study, we examined how trait anger and anger expression influenced the likelihood of suicide attempts among 180 adolescents followed for up to 13.3 years after…

  3. A prospective study of the influence of acute alcohol intoxication versus chronic alcohol consumption on outcome following traumatic brain injury.

    Science.gov (United States)

    Lange, Rael T; Shewchuk, Jason R; Rauscher, Alexander; Jarrett, Michael; Heran, Manraj K S; Brubacher, Jeffrey R; Iverson, Grant L

    2014-08-01

    The purpose of the study was to disentangle the relative contributions of day-of-injury alcohol intoxication and pre-injury alcohol misuse on outcome from TBI. Participants were 142 patients enrolled from a Level 1 Trauma Center (in Vancouver, Canada) following a traumatic brain injury (TBI; 43 uncomplicated mild TBI and 63 complicated mild-severe TBI) or orthopedic injury [36 trauma controls (TC)]. At 6-8 weeks post-injury, diffusion tensor imaging (DTI) of the whole brain was undertaken using a Phillips 3T scanner. Participants also completed neuropsychological testing, an evaluation of lifetime alcohol consumption (LAC), and had blood alcohol levels (BALs) taken at the time of injury. Participants in the uncomplicated mild TBI and complicated mild-severe TBI groups had higher scores on measures of depression and postconcussion symptoms (d = 0.45-0.83), but not anxiety, compared with the TC group. The complicated mild-severe TBI group had more areas of abnormal white matter on DTI measures (all p executive functioning abilities; however, the variance accounted for was small. LAC and BAL did not provide a unique and meaningful contribution toward the prediction of self-reported symptoms, DTI measures, or the majority of neurocognitive measures. In this study, BAL and LAC were not predictive of mental health symptoms, postconcussion symptoms, cognition, or white-matter changes at 6-8 weeks following TBI. PMID:24964748

  4. Prospective studies on children with sex chromosome aneuploidy

    Energy Technology Data Exchange (ETDEWEB)

    Ratcliffe, S.G.; Paul, N.

    1986-01-01

    This book contains 11 selections. Some of the titles are: Growth and Development from Early to Midadolescence of Children with X and Y Chromosome Aneuploidy: The Toronto Study; Sex Chromomal Aneuploidy: Perspective and Longitudinal Studies; Psychologic Study of XYY and XXY Men; and Cellular and Molecular Studies in Human Chromosomal Diseases.

  5. UK pneumonectomy outcome study (UKPOS: a prospective observational study of pneumonectomy outcome

    Directory of Open Access Journals (Sweden)

    Davies Paul

    2009-07-01

    Full Text Available Abstract Background In order to assess the short term risks of pneumonectomy for lung cancer in contemporary practice a one year prospective observational study of pneumonectomy outcome was made. Current UK practice for pneumonectomy was observed to note patient and treatment factors associated with major complications. Methods A multicentre, prospective, observational cohort study was performed. All 35 UK thoracic surgical centres were invited to submit data to the study. All adult patients undergoing pneumonectomy for lung cancer between 1 January and 31 December 2005 were included. Patients undergoing pleuropneumonectomy, extended pneumonectomy, completion pneumonectomy following previous lobectomy and pneumonectomy for benign disease, were excluded from the study. The main outcome measure was suffering a major complication. Major complications were defined as: death within 30 days of surgery; treated cardiac arrhythmia or hypotension; unplanned intensive care admission; further surgery or inotrope usage. Results 312 pneumonectomies from 28 participating centres were entered. The major complication incidence was: 30-day mortality 5.4%; treated cardiac arrhythmia 19.9%; unplanned intensive care unit admission 9.3%; further surgery 4.8%; inotrope usage 3.5%. Age, American Society of Anesthesiologists physical status ≥ P3, pre-operative diffusing capacity for carbon monoxide (DLCO and epidural analgesia were collectively the strongest risk factors for major complications. Major complications prolonged median hospital stay by 2 days. Conclusion The 30 day mortality rate was less than 8%, in agreement with the British Thoracic Society guidelines. Pneumonectomy was associated with a high rate of major complications. Age, ASA physical status, DLCO and epidural analgesia appeared collectively most associated with major complications.

  6. Chronic Stress is Prospectively Associated with Sleep in Midlife Women: The SWAN Sleep Study

    Science.gov (United States)

    Hall, Martica H.; Casement, Melynda D.; Troxel, Wendy M.; Matthews, Karen A.; Bromberger, Joyce T.; Kravitz, Howard M.; Krafty, Robert T.; Buysse, Daniel J.

    2015-01-01

    Study Objectives: Evaluate whether levels of upsetting life events measured over a 9-y period prospectively predict subjective and objective sleep outcomes in midlife women. Design: Prospective cohort study. Setting: Four sites across the United States. Participants: 330 women (46–57 y of age) enrolled in the Study of Women's Health Across the Nation (SWAN) Sleep Study. Interventions: N/A. Measurements and Results: Upsetting life events were assessed annually for up to 9 y. Trajectory analysis applied to life events data quantitatively identified three distinct chronic stress groups: low stress, moderate stress, and high stress. Sleep was assessed by self-report and in-home polysomnography (PSG) during the ninth year of the study. Multivariate analyses tested the prospective association between chronic stress group and sleep, adjusting for race, baseline sleep complaints, marital status, body mass index, symptoms of depression, and acute life events at the time of the Sleep Study. Women characterized by high chronic stress had lower subjective sleep quality, were more likely to report insomnia, and exhibited increased PSG-assessed wake after sleep onset (WASO) relative to women with low to moderate chronic stress profiles. The effect of chronic stress group on WASO persisted in the subsample of participants without baseline sleep complaints. Conclusions: Chronic stress is prospectively associated with sleep disturbance in midlife women, even after adjusting for acute stressors at the time of the sleep study and other factors known to disrupt sleep. These results are consistent with current models of stress that emphasize the cumulative effect of stressors on health over time. Citation: Hall MH, Casement MD, Troxel WM, Matthews KA, Bromberger JT, Kravitz HM, Krafty RT, Buysse DJ. Chronic stress is prospectively associated with sleep in midlife women: the SWAN Sleep Study. SLEEP 2015;38(10):1645–1654. PMID:26039965

  7. Fracture Risk Assessment in Chronic Kidney Disease, Prospective Testing Under Real World Environments (FRACTURE: a prospective study

    Directory of Open Access Journals (Sweden)

    West Sarah L

    2010-08-01

    Full Text Available Abstract Background Chronic kidney disease (CKD is associated with an increased risk of fracture. Decreased bone mass and disruption of microarchitecture occur early in the course of CKD and worsens with the progressive decline in renal function so that at the time of initiation of dialysis at least 50% of patients have had a fracture. Despite the excess fracture risk, and the associated increases in morbidity and mortality, little is known about the factors that are associated with an increase in fracture risk. Our study aims to identify prognostic factors for bone loss and fractures in patients with stages 3 to 5 CKD. Methods This prospective study aims to enroll two hundred and sixty men and women with stages 3 to 5 CKD. Subjects will be followed for 24 months and we will examine the ability of: 1 bone mineral density by dual x-ray absorptiometry at the spine, hip, and radius; 2 volumetric bone density by high resolution peripheral quantitated computed tomography at the radius and tibia; 3 serum markers of bone turnover; 4 bone formation rate by bone biopsy; and 5 muscle strength and balance to predict spine and non-spine fractures, identified by self-report and/or vertebral morphometry. All measurements will be obtained at baseline, at 12 and at 24 months with the exception of bone biopsy, which will be measured once at 12 months. Subjects will be contacted every 4 months to determine if there have been incident fractures or falls. Discussion This study is one of the first that aims to identify risk factors for fracture in early stage CKD patients. Ultimately, by identifying risk factors for fracture and targeting treatments in this group-before the initiation of renal replacement therapy - we will reduce the burden of disease due to fractures among patients with CKD.

  8. Cognitive Coping Strategies and Stress in Parents of Children with Down Syndrome: A Prospective Study

    Science.gov (United States)

    van der Veek, Shelley M. C.; Kraaij, Vivian; Garnefski, Nadia

    2009-01-01

    The purpose of this study was to explore the cross-sectional and prospective relationships between cognitive coping strategies and parental stress in parents of children with Down syndrome. A total of 621 participants filled out questionnaires, including the Cognitive Emotion Regulation Questionnaire to measure cognitive coping and the Nijmeegse…

  9. Work-site musculoskeletal pain risk estimates by trained observers - a prospective cohort study

    NARCIS (Netherlands)

    Coenen, P.; Kingma, I.; Boot, C.R.L.; Douwes, M.; Bongers, P.M.; Dieën, J.H. van

    2012-01-01

    Work-related musculoskeletal pain (MSP) risk assessments by trained observers are often used in ergonomic practice; however, the validity may be questionable. We investigated the predictive value of work-site MSP risk estimates in a prospective cohort study of 1745 workers. Trained observers estimat

  10. A Study of Prospective Turkish Science Teachers' Knowledge at the Popular Biotechnological Issues

    Science.gov (United States)

    Darcin, Emine Selcen; Turkmen, Lutfullah

    2006-01-01

    The purpose of this study was to determine the knowledge level of popular biotechnological issues of prospective Turkish science teachers. A questionnaire was administered during 2005-2006 academic year to 194 students in the Department of Science Education of a university in Turkey. The questionnaire covered six biotechnological issues such as…

  11. How distressing is referral to colposcopy in cervical cancer screening? : A prospective quality of life study

    NARCIS (Netherlands)

    I.J. Korfage (Ida); M.L.E. Essink-Bot (Marie-Louise); S.M. Westenberg (Steven); T.J.M. Helmerhorst (Theo); J.D.F. Habbema (Dik); M. van Ballegooijen (Marjolein)

    2014-01-01

    textabstractObjective Referral for colposcopy because of abnormal Pap test results is likely to be distressing, but the extent and duration of these effects are unknown. We aimed to fill this gap. Methods We conducted a prospective observational study at two departments of Obstetrics and Gynecology

  12. Digital protocol for reference-based guided surgery and immediate loading: a prospective clinical study

    NARCIS (Netherlands)

    A. Tahmaseb; R. de Clerck; I. Aartman; D. Wismeijer

    2012-01-01

    PURPOSE: To evaluate the performance of a computer-aided three-dimensional planning protocol in combination with previously inserted reference mini-implants and CAD/CAM technology to restore completely edentulous patients. The study evaluated implant and superstructure survival in a prospective clin

  13. A Bayesian hierarchical approach for combining case-control and prospective studies.

    Science.gov (United States)

    Müller, P; Parmigiani, G; Schildkraut, J; Tardella, L

    1999-09-01

    Motivated by the absolute risk predictions required in medical decision making and patient counseling, we propose an approach for the combined analysis of case-control and prospective studies of disease risk factors. The approach is hierarchical to account for parameter heterogeneity among studies and among sampling units of the same study. It is based on modeling the retrospective distribution of the covariates given the disease outcome, a strategy that greatly simplifies both the combination of prospective and retrospective studies and the computation of Bayesian predictions in the hierarchical case-control context. Retrospective modeling differentiates our approach from most current strategies for inference on risk factors, which are based on the assumption of a specific prospective model. To ensure modeling flexibility, we propose using a mixture model for the retrospective distributions of the covariates. This leads to a general nonlinear regression family for the implied prospective likelihood. After introducing and motivating our proposal, we present simple results that highlight its relationship with existing approaches, develop Markov chain Monte Carlo methods for inference and prediction, and present an illustration using ovarian cancer data. PMID:11315018

  14. Pooled analysis of prospective cohort studies on height, weight and breast cancer risk

    NARCIS (Netherlands)

    Brandt, P.A. van den; Spiegelman, D.; Yaun, S-S.; Adami, H-O.; Beeson, L.; Folsom, A.R.; Fraser, G.; Goldbohm, R.A.; Graham, S.; Kushi, L.; Marshall, J.R.; Miller, A.B.; Rohan, T.; Smith-Warner, S.A.; Speizer, F.E.; Willett, W.C.; Wolk, A.; Hunter, D.J.

    2000-01-01

    The association between anthropometric indices and the risk of breast cancer was analyzed using pooled data from seven prospective cohort studies. Together, these cohorts comprise 337,819 women and 4,385 incident invasive breast cancer cases. In multivariate analyses controlling for reproductive, di

  15. The Effects of Divorce and Parental Conflict on Children's Adjustment: A Prospective Study.

    Science.gov (United States)

    Shaw, Daniel

    Replicating the methodology used by Block, Block, and Gjerde (1986), a prospective, longitudinal examination was made of relations between divorce and children's adjustment. Data from the New York Longitudinal Study (NYLS), originally collected by Thomas, Chess, and Birch (1963, 1968, 1977, 1983, 1984) was analyzed. The NYLS assessed children's…

  16. Rumination and Depression in Adolescence: Investigating Symptom Specificity in a Multiwave Prospective Study

    Science.gov (United States)

    Hankin, Benjamin L.

    2008-01-01

    A ruminative response style has been shown to predict depressive symptoms among youth and adults, but it is unclear whether rumination is associated specifically with depression compared with co-occurring symptoms of anxiety and externalizing behaviors. This prospective, multiwave study investigated whether baseline rumination predicted…

  17. Dietary fiber intake and risk of colorectal cancer: A pooled analysis of prospective cohort studies

    NARCIS (Netherlands)

    Park, Y.; Hunter, D.J.; Spiegelman, D.; Bergkvist, L.; Berrino, F.; Brandt, P.A. van den; Buring, J.E.; Colditz, G.A.; Freudenheim, J.L.; Fuchs, C.S.; Giovannucci, E.; Goldbohm, R.A.; Graham, S.; Harnack, L.; Hartman, A.M.; Jacobs, D.R.; Kato, I.; Krogh, V.; Leitzmann, M.F.; McCullough, M.L.; Miller, A.B.; Pietinen, P.; Rohan, T.E.; Schatzkin, A.; Willett, W.C.; Wolk, A.; Zeleniuch-Jacquotte, A.; Zhang, S.M.; Smith-Warner, S.A.

    2005-01-01

    Context: Inconsistent findings from observational studies have continued the controversy over the effects of dietary fiber on colorectal cancer. Objective: To evaluate the association between dietary fiber intake and risk of colorectal cancer. Design, Setting, and Participants: From 13 prospective c

  18. Toenail selenium levels and the subsequent risk of prostate cancer: A prospective cohort study

    NARCIS (Netherlands)

    Brandt, P.A. van den; Zeegers, M.P.A.; Bode, P.; Goldbohm, R.A.

    2003-01-01

    Results of a randomized controlled trial have suggested a protective effect of selenium against prostate cancer. Few other prospective studies have been conducted to confirm or refute this. The association between prostate cancer and baseline toenail selenium level was evaluated in the Netherlands C

  19. Mouth opening in patients irradiated for head and neck cancer : A prospective repeated measures study

    NARCIS (Netherlands)

    Kamstra, J. I.; Dijkstra, P. U.; van Leeuwen, M.; Roodenburg, J. L. N.; Langendijk, J. A.

    2015-01-01

    Objectives: Aims of this prospective cohort study were (1) to analyze the course of mouth opening up to 48 months post-radiotherapy (RT), (2) to assess risk factors predicting decrease in mouth opening, and (3) to develop a multivariable prediction model for change in mouth opening in a large sample

  20. Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study

    NARCIS (Netherlands)

    A. Dubin; M.O. Pozo; C.A. Casabella; F.,Jr Pálizas; G. Murias; M.C. Moseinco; V.S. Kanoore Edul; F. Pálizas; E. Estenssoro; C. Ince

    2009-01-01

    Introduction Our goal was to assess the effects of titration of a norepinephrine infusion to increasing levels of mean arterial pressure (MAP) on sublingual microcirculation. Methods Twenty septic shock patients were prospectively studied in two teaching intensive care units. The patients were mecha

  1. How Can We Get the Information about Democracy? The Example of Social Studies Prospective Teachers

    Science.gov (United States)

    Tonga, Deniz

    2014-01-01

    In this research, the information about democracy, which social studies prospective teachers have, and interpretation of the information sources are aimed. The research was planned as a survey research methodology and the participants were determined with criterion sampling method. The data were collected through developed open-ended questions…

  2. Predicting mobility outcome one year after stroke: a prospective cohort study.

    NARCIS (Netherlands)

    Port, I.G. van de; Kwakkel, G.; Schepers, V.P.; Lindeman, E.

    2006-01-01

    OBJECTIVE: To develop a prognostic model to predict mobility outcome one year post-stroke. DESIGN: Prospective cohort study in patients with a first-ever stroke admitted for inpatient rehabilitation. PATIENTS: A total of 217 patients with stroke (mean age 58 years) following inpatient rehabilitation

  3. Prospective study of falls and risk factors for falls in adults with advanced cancer.

    LENUS (Irish Health Repository)

    Stone, Carol A

    2012-06-10

    Retrospective studies of inpatients with cancer suggest that a cancer diagnosis confers a high risk of falls. In adults with advanced cancer, we aimed to prospectively document the incidence of falls, identify the risk factors, and determine if falls in this population occur predominantly in older patients.

  4. Stressful life events and leukocyte telomere attrition in adulthood : a prospective population-based cohort study

    NARCIS (Netherlands)

    van Ockenburg, S. L.; Bos, E. H.; de Jonge, P.; van der Harst, P.; Gans, R. O. B.; Rosmalen, J. G. M.

    2015-01-01

    Background. Telomere attrition might be one of the mechanisms through which psychosocial stress leads to somatic disease. To date it is unknown if exposure to adverse life events in adulthood is associated with telomere shortening prospectively. In the current study we investigated whether life even

  5. Mediating Mechanisms for the Intergenerational Transmission of Constructive Parenting: A Prospective Longitudinal Study

    Science.gov (United States)

    Chen, Zeng-yin; Liu, Ruth X.; Kaplan, Howard B.

    2008-01-01

    Based on a prospective longitudinal panel data set that was collected at three developmental stages--early adolescence, young adulthood, and middle adulthood--this study investigates marital satisfaction and educational attainment as mediating mechanisms as well as gender's moderating effect for the intergenerational transmission of constructive…

  6. Do Specific Types of Networking Predict Specific Mobility Outcomes? A Two-Year Prospective Study

    Science.gov (United States)

    Wolff, Hans-Georg; Moser, Klaus

    2010-01-01

    Previous research has established a general relation between networking and career outcomes, as postulated by theories on protean careers and career self management. We suggest that specific facets of networking behavior differentially affect specific career mobility outcomes over time. In a 2-year prospective study, we examined the impact of six…

  7. Predictors and Health-Related Outcomes of Positive Body Image in Adolescent Girls: A Prospective Study

    Science.gov (United States)

    Andrew, Rachel; Tiggemann, Marika; Clark, Levina

    2016-01-01

    This study aimed to investigate prospective predictors and health-related outcomes of positive body image in adolescent girls. In so doing, the modified acceptance model of intuitive eating was also examined longitudinally. A sample of 298 girls aged 12 to 16 years completed a questionnaire containing measures of body appreciation, potential…

  8. Vitamin D deficiency and age at menarche: a prospective study123

    OpenAIRE

    Villamor, Eduardo; Marin, Constanza; Mora-Plazas, Mercedes; Baylin, Ana

    2011-01-01

    Background: Early menarche is a risk factor for cardiometabolic disease and cancer. Latitude, which influences sun exposure, is inversely related to age at menarche. This association might be related to vitamin D, but to our knowledge it has not been investigated in prospective epidemiologic studies.

  9. The Interpersonal Antecedents of Supportive Parenting: A Prospective, Longitudinal Study from Infancy to Adulthood

    Science.gov (United States)

    Raby, K. Lee; Lawler, Jamie M.; Shlafer, Rebecca J.; Hesemeyer, Paloma S.; Collins, W. Andrew; Sroufe, L. Alan

    2015-01-01

    This study drew on prospective, longitudinal data to test the hypothesis that the intergenerational transmission of positive parenting is mediated by competence in subsequent relationships with peers and romantic partners. Interview-based ratings of supportive parenting were completed with a sample of 113 individuals (46% male) followed from birth…

  10. A Prospective Study of Risk Factors for the Development of Depression and Disordered Eating in Adolescents

    Science.gov (United States)

    Ferreiro, Fatima; Seoane, Gloria; Senra, Carmen

    2011-01-01

    There is evidence that females display higher levels of depressive symptoms and disordered eating than males from adolescence onward. This study examined whether different risk factors and their interaction with sex (moderator effect) prospectively predicted depressive symptoms and disordered eating in adolescents. A total of 415 female…

  11. Beliefs of Applied Studio Faculty on Desirable Traits of Prospective Music Education Majors: A Pilot Study

    Science.gov (United States)

    Royston, Natalie Steele; Springer, D. Gregory

    2015-01-01

    The purpose of this pilot study was to examine the beliefs of applied music faculty on desirable traits of prospective music education majors. Researcher-designed surveys were sent electronically to applied music faculty at 12 National Association of Schools of Music-accredited institutions randomly selected from each of the four major divisions…

  12. A Prospective Longitudinal Study of High School Dropouts: Examining Multiple Predictors across Development.

    Science.gov (United States)

    Jimerson, Shane; Egeland, Byron; Sroufe, L. Alan; Carlson, Betty

    2000-01-01

    Utilizes data from a prospective longitudinal study of at-risk children to explore multiple predictors of high school dropouts across development. Results reveal association of early home environment, quality of early caregiving, socioeconomic status, IQ, behavior problems, academic achievement, peer relations, and parent involvement with dropping…

  13. First aid and basic life support of junior doctors: A prospective study in Nijmegen, the Netherlands.

    NARCIS (Netherlands)

    Tan, E.C.T.H.; Severien, I.; Metz, J.C.; Berden, H.J.J.M.; Biert, J.

    2006-01-01

    According to the Dutch medical education guidelines junior doctors are expected to be able to perform first aid and basic life support. A prospective study was undertaken to assess the level of first aid and basic life support (BLS) competence of junior doctors at the Radboud University Nijmegen Med

  14. Predicting Dyslexia in a Transparent Orthography from Grade 1 Literacy Skills: A Prospective Cohort Study

    Science.gov (United States)

    Bigozzi, Lucia; Tarchi, Christian; Pinto, Giuliana; Accorti Gamannossi, Beatrice

    2016-01-01

    We conducted this prospective cohort study to explore the predictability of dyslexia from 1st-grade literacy skills in Italian students. We followed 407 Italian students in primary school from the 1st through the 3rd grades. Students were diagnosed with dyslexia in the 3rd grade. We retrospectively tested participants' 1st-grade performance in…

  15. Maternal cortisol and offspring birthweight: Results from a large prospective cohort study

    NARCIS (Netherlands)

    G. Goedhart; T.G.M. Vrijkotte; T.J. Roseboom; M.F. van der Wal; P. Cuijpers; G.J. Bonsel

    2010-01-01

    Maternal psychosocial problems may affect fetal growth through maternal cortisol. This large prospective cohort study examined among 2810 women (1) the association of maternal cortisol levels with offspring birthweight and small for gestational age (SGA) risk and (2) the mediating role of maternal c

  16. Adverse drug reactions to tocolytic treatment for preterm labour : prospective cohort study

    NARCIS (Netherlands)

    de Heus, R.; Mol, B.W.; Erwich, J.J.H.M.; van Geijn, H.P.; Gyselaers, W.J.; Hanssens, M.; Harmark, L.; van Holsbeke, C.D.; Duvekot, J.J.; Schobben, F.F.A.M.; Wolf, Hans; Visser, G.H.A.

    2009-01-01

    Objective To evaluate the incidence of serious maternal complications after the use of various tocolytic drugs for the treatment of preterm labour in routine clinical situations. Design Prospective cohort study. Setting 28 hospitals in the Netherlands and Belgium. Participants 1920 consecutive women

  17. Adverse drug reactions to tocolytic treatment for preterm labour: prospective cohort study

    NARCIS (Netherlands)

    R. de Heus; B.W. Mol; J.J.H.M. Erwich; H.P. van Geijn; W.J. Gyselaers; M. Hanssens; L. Härmark; C.D. van Holsbeke; J.J. Duvekot; F.F.A.M. Schobben; H. Wolf; G.H.A. Visser

    2009-01-01

    Objective To evaluate the incidence of serious maternal complications after the use of various tocolytic drugs for the treatment of preterm labour in routine clinical situations. Design Prospective cohort study. Setting 28 hospitals in the Netherlands and Belgium. Participants 1920 consecutive women

  18. Adverse drug reactions to tocolytic treatment for preterm labour: prospective cohort study

    NARCIS (Netherlands)

    Heus, R.; Mol, B.W.; Erwich, J.J.; Geijn, van H.; Gyselaers, W.J.; Hanssens, M.; Harmark, L.; Holsbeke, van C.D.; Duvekot, J.J.; Schobben, F.F.; Wolf, de H.; Visser, G.H.A.

    2009-01-01

    OBJECTIVE: To evaluate the incidence of serious maternal complications after the use of various tocolytic drugs for the treatment of preterm labour in routine clinical situations. DESIGN: Prospective cohort study. SETTING: 28 hospitals in the Netherlands and Belgium. PARTICIPANTS: 1920 consecutive w

  19. A systematic review of prospective studies on attention problems and academic achievement

    NARCIS (Netherlands)

    T.J.C. Polderman; D.I. Boomsma; M. Bartels; F.C. Verhulst; A.C. Huizink

    2010-01-01

    Objective:  Our aim was to provide an overview of prospective studies that have addressed the association between attention problems (AP, i.e. symptoms of hyperactivity and inattentiveness) and academic achievement (AA). Method:  We conducted a systematic search in the literature. Normal population

  20. First-onset psychosis occurring in the postpartum period: A prospective cohort study

    NARCIS (Netherlands)

    V. Bergink (Veerle); M.P. Lambregtse-van den Berg (Mijke); K.M. Koorengevel (Kathelijne); R.W. Kupka (Ralph ); S.A. Kushner (Steven)

    2011-01-01

    textabstractObjective: To prospectively characterize a cohort of patients for whom first lifetime episode of psychosis occurs in the postpartum period. Method: Included in the study were 51 women admitted to an inpatient facility for postpartum psychosis and a population-based control group (n = 6,9

  1. Risk factors for congenital cryptorchidism in a prospective birth cohort study

    DEFF Research Database (Denmark)

    Damgaard, Ida N; Jensen, Tina K; Petersen, Jørgen H;

    2008-01-01

    BACKGROUND: Risk factors for congenital cryptorchidism were investigated in a prospective birth cohort study in Denmark and Finland from 1997 to 2001. METHODOLOGY AND PRINCIPAL FINDINGS: In total, 2,496 boys were examined for cryptorchidism at birth (cryptorchid/healthy: 128/2,368) and three mont...

  2. COLLABORATIVE PROSPECTIVE-STUDY OF THE FRAGILE-X SYNDROME - ONE-YEAR PROGRESS REPORT

    NARCIS (Netherlands)

    SHERMAN, SL; BARBI, G; BRONDUMNIELSEN, K; BROWN, WT; CARPENTER, NJ; CHUDLEY, AE; FERRAZ, OP; FERREIRA, P; GUSTAVSON, KH; HALLIDAY, J; HOCKEY, A; HOWARDPEEBLES, PN; JENKINS, E; KENNERKNECHT, [No Value; KAHKONEN, M; LADAIQUE, P; LEISTI, J; MADDALENA, A; MAZURCZAK, T; MATTEI, JF; MATTINA, T; MCKINLEY, MJ; MURPHY, P; PELLISSIER, MC; PURVISSMITH, S; ROBINSON, H; SCAPAGNINI, U; SCHAAP, T; SHAPIRO, LR; SMITS, APT; STEINBACH, P; TURNER, G; UCHIDA, IA; VANOOST, BA; VOELCKEL, MA; WEAVER, DD; WEBB, T

    1992-01-01

    A prospective study of the fragile X syndrome [fra(X)] was initiated one year ago to refine the estimates of recurrence risks based on the phenotype of the mother and the family history of the syndrome. The basic unit of data consists of the description of the conceptus of women known to carry the f

  3. Distress in suspected lung cancer patients following rapid and standard diagnostic programs: a prospective observational study

    NARCIS (Netherlands)

    Brocken, P.; Heijden, E.H. van der; Oud, K.T.; Bootsma, G.; Groen, H.J.M.; Donders, A.R.T.; Dekhuijzen, P.N.R.; Prins, J.B.

    2015-01-01

    OBJECTIVE: Timeliness may influence emotional distress during the diagnostic phase of suspected lung cancer patients. We performed a prospective observational study to compare distress and quality of life (QoL) in two medical centres with a Rapid Outpatient Diagnostic Program (RODP) and two using co

  4. Advanced Life Support in Obstetrics (ALSO) and postpartum hemorrhage: A prospective intervention study in Tanzania

    DEFF Research Database (Denmark)

    Sorensen, Bjarke Lund; Rasch, Vibeke; Massawe, Siriel;

    2011-01-01

    Objective. To evaluate the impact of Advanced Life Support in Obstetrics (ALSO) training on staff performance and the incidences of postpartum hemorrhage (PPH) at a regional hospital in Tanzania. Design. Prospective intervention study. Setting. A regional, referral hospital. Population. A total...

  5. Functional prognosis of dizziness in older adults in primary care: a prospective cohort study.

    NARCIS (Netherlands)

    Dros, J.; Maarsingh, O.R.; Beem, L.; Horst, H.E. van der; Riet, G. ter; Schellevis, F.G.; Weert, H.C.P.M. van

    2012-01-01

    Objectives: To investigate the 6-month functional prognosis of dizziness in older adults in primary care, to identify important predictors of dizziness-related impairment, and to construct a score to assist risk prediction. Design: Prospective cohort study with 6-month follow-up. Setting: Twenty-fou

  6. Prospective study on dietary intakes of folate, betaine, and choline and cardiovascular disease risk in women

    NARCIS (Netherlands)

    Dalmeijer, G.W.; Olthof, M.R.; Verhoef, P.; Bots, M.L.; Schouw, van der Y.T.

    2008-01-01

    Objective: To investigate the association between dietary intakes of folate, betaine and choline and the risk of cardiovascular disease (CVD). Design: Prospective cohort study. Subjects: A total of 16 165 women aged 49¿70 years without prior CVD. Subjects were breast cancer screening participants in

  7. Intake of nitrate and nitrite and the risk of gastric cancer: A prospective cohort study

    NARCIS (Netherlands)

    Loon, A.J.M. van; Botterweck, A.A.M.; Goldbohm, R.A.; Brants, H.A.M.; Klaveren, J.D. van; Brandt, P.A. van den

    1998-01-01

    The association between the intake of nitrate or nitrite and gastric cancer risk was investigated in a prospective cohort study started in 1986 in the Netherlands, of 120,852 men and women aged 55-69 years. At baseline, data on dietary intake, smoking habits and other covariates were collected by me

  8. A prospective study on parental coping 4 months after termination of pregnancy for fetal anomalies

    NARCIS (Netherlands)

    Korenromp, M. J.; Page-Christiaens, G. C. M. L.; van den Bout, J.; Mulder, E. J. H.; Hunfeld, J. A. M.; Potters, C. M. A. A.; Erwich, J. J. H. M.; van Binsbergen, C. J. M.; Brons, J. T. J.; Omtzigt, A. W. J.; Visser, G. H. A.; Beekhuis, J.R.

    2007-01-01

    Objective To identify short-term factors influencing psychological outcome of termination of pregnancy for fetal anomaly, in order to define those patients most vulnerable to psychopathology. Study Design A prospective cohort of 217 women and 169 men completed standardized questionnaires 4 months af

  9. Sociocultural and Individual Psychological Predictors of Body Image in Young Girls: A Prospective Study

    Science.gov (United States)

    Clark, Levina; Tiggemann, Marika

    2008-01-01

    This study investigated the prospective predictors of body image in 9- to 12-year-old girls. Participants were 150 girls in Grades 4-6 with a mean age of 10.3 years. Girls completed questionnaire measures of media and peer influences (television/magazine exposure, peer appearance conversations), individual psychological variables (appearance…

  10. Soccer injuries and recovery in dutch male amateur soccer players: Results of a prospective cohort study

    NARCIS (Netherlands)

    Beijsterveldt, A.M. van; Steffen, K.; Stubbe, J.H.; Frederiks, J.E.; Port, I.G.L. van de; Backx, F.J.G.

    2014-01-01

    OBJECTIVE:: To describe characteristics of outdoor soccer injury and recovery among Dutch soccer players. DESIGN:: Prospective cohort study. SETTING:: The 2009-2010 competitive season (33 weeks). PARTICIPANTS:: Four hundred fifty-six Dutch male soccer players of 23 amateur teams. MAIN OUTCOME MEASUR

  11. A prospective study on active and environmental tobacco smoking and bladder cancer risk (The Netherlands)

    NARCIS (Netherlands)

    Zeegers, M.P.A.; Goldbohm, R.A.; Brandt, P.A. van den

    2002-01-01

    Objective: In a prospective cohort study among 120,852 adult subjects the authors investigated the associations between cigarette, cigar, pipe, environmental tobacco smoking (ETS), and bladder cancer. Methods: In 1986 all subjects completed a questionnaire on cancer risk factors. Follow-up for incid

  12. Treatment of traumatic thoracolumbar spine fractures : A multicenter prospective randomized study of operative versus nonsurgical treatment

    NARCIS (Netherlands)

    Siebenga, Jan; Leferink, Vincent J. M.; Segers, Michiel J. M.; Elzinga, Matthijs J.; Bakker, Fred C.; Haarman, Henk J. Th. M.; Rommens, Pol M.; ten Duis, Henk-Jan; Patka, Peter

    2006-01-01

    Study Design. Multicenter prospective randomized trial. Objective. To test the hypotheses that thoracolumbar AO Type A spine fractures without neurologic deficit, managed with short-segment posterior stabilization will show an improved radiographic outcome and at least the same functional outcome as

  13. Outcome of HCV/HIV-coinfected liver transplant recipients: a prospective and multicenter cohort study.

    NARCIS (Netherlands)

    Miro, J.M.; Montejo, M.; Castells, L.; Rafecas, A.; Moreno, S.; Aguero, F.; Abradelo, M.; Miralles, P.; Torre-Cisneros, J.; Pedreira, J.D.; Cordero, E.; Rosa, G. De; Moyano, B.; Moreno, A.; Perez, I.; Rimola, A.; Barrera, P.

    2012-01-01

    Eighty-four HCV/HIV-coinfected and 252-matched HCV-monoinfected liver transplant recipients were included in a prospective multicenter study. Thirty-six (43%) HCV/HIV-coinfected and 75 (30%) HCV-monoinfected patients died, with a survival rate at 5 years of 54% (95% CI, 42-64) and 71% (95% CI, 66 to

  14. Does Attention Constrain Developmental Trajectories in Fragile X Syndrome? A 3-Year Prospective Longitudinal Study

    Science.gov (United States)

    Cornish, Kim; Cole, Victoria; Longhi, Elena; Karmiloff-Smith, Annette; Scerif, Gaia

    2012-01-01

    Basic attentional processes and their impact on developmental trajectories in fragile X syndrome were assessed in a 3-year prospective study. Although fragile X syndrome is a monogenic X-linked disorder, there is striking variability in outcomes even in young boys with the condition. Attention is a key factor constraining interactions with the…

  15. General practitioners' continuing medical education: A prospective study from the County of Aarhus

    DEFF Research Database (Denmark)

    Nielsen, Jan E.; Lous, Jørgen; Adeler, H.F.;

    2002-01-01

    Participation of Danish general practitioners (GPs) in continuing medical education (CME) has often been the subject of debate, although very little is known about the extent and content of activities. One-hundred-and-sixty-one Danish GPs participated in this one-year prospective study...

  16. Clinical Observed Performance Evaluation: A Prospective Study in Final Year Students of Surgery

    Science.gov (United States)

    Markey, G. C.; Browne, K.; Hunter, K.; Hill, A. D.

    2011-01-01

    We report a prospective study of clinical observed performance evaluation (COPE) for 197 medical students in the pre-qualification year of clinical education. Psychometric quality was the main endpoint. Students were assessed in groups of 5 in 40-min patient encounters, with each student the focus of evaluation for 8 min. Each student had a series…

  17. A Prospective Study of Pedometer-Determined Physical Activity and Physical Self-Perceptions in Children

    Science.gov (United States)

    Morgan, Charles F.; Graser, Susan Vincent; Pangrazi, Robert P.

    2008-01-01

    There have been limited prospective studies investigating physical activity and physical self-perceptions in children. In this investigation, mean steps/day did not significantly change from late elementary to junior high for either boys or girls; however, boys accumulated more steps both at baseline and follow-up. Physical self-perception…

  18. Asymptomatic spontaneous cerebral emboli and mood in a cohort of older people: a prospective study.

    NARCIS (Netherlands)

    Oude Voshaar, R.C.; Purandare, N.; Hardicre, J.; McCollum, C.N.; Burns, A.

    2007-01-01

    OBJECTIVE: To examine whether asymptomatic spontaneous cerebral emboli (SCE) predicts subsequent depression in older people. METHODS: Prospective cohort study with 2.5 years of follow-up including 96 nondepressed older subjects in primary care. Presence of SCE was measured at baseline by transcrania

  19. A systematic review of prospective studies on attention problems and academic achievement

    NARCIS (Netherlands)

    Polderman, T.J.C.; Boomsma, D.I.; Bartels, M.; Verhulst, F.C.; Huizink, A.C.

    2010-01-01

    Objective: Our aim was to provide an overview of prospective studies that have addressed the association between attention problems (AP, i.e. symptoms of hyperactivity and inattentiveness) and academic achievement (AA). Method: We conducted a systematic search in the literature. Normal population st

  20. Mandibular overdentures supported by two Branemark, IMZ or ITI implants : a 5-year prospective study

    NARCIS (Netherlands)

    Meijer, HJA; Batenburg, RHK; Raghoebar, GM; Vissink, A

    2004-01-01

    Objectives: The aim of this prospective comparative study was to evaluate the survival rate and the condition of the peri-implant tissues of the IMZ implant system (two-stage cylindertype), the Branemark implant system (two-stage screwtype) and the ITI implant system (one-stage screwtype) supporting

  1. The extremely resorbed mandible : A comparative prospective study of 2-year results with 3 treatment strategies

    NARCIS (Netherlands)

    Stellingsma, Kees; Raghoebar, Gerry M.; Meijer, Henny J.A.; Stegenga, Boudewijn

    2004-01-01

    Purpose: The aim of this prospective clinical study was to compare the clinical and radiographic results of 3 modes of implant treatment in combination with an overdenture in patients with extremely resorbed mandibles. The 3 treatment strategies used were a transmandibular implant, augmentation of t

  2. Dynasplint Trismus System exercises for trismus secondary to head and neck cancer : a prospective explorative study

    NARCIS (Netherlands)

    Kamstra, Jolanda I.; Reintsema, Harry; Roodenburg, Jan L. N.; Dijkstra, Pieter U.

    2016-01-01

    The Dynasplint Trismus System (DTS) can be used to treat trismus secondary to head and neck cancer. We conducted a prospective study with the following aims: (1) to determine the effects of DTS exercises on changes in mouth opening, pain, mandibular function, quality of life (QoL), and symptomatolog

  3. Antioxidants, oxidative stress, and cardiovascular diseases : cross-cultural comparisons and prospective cohort studies

    NARCIS (Netherlands)

    Buijsse, B.

    2008-01-01

    Background: Antioxidants in plant foods have been proposed to reduce the risk of cardiovascular diseases (CVD) by reducing oxidative stress. The objective was to confirm prospective studies on CVD and traditional antioxidants (beta-carotene, alpha-tocopherol), and to investigate emerging antioxidant

  4. The Short-Term Impact of Involuntary Migration in China's Three Gorges: A Prospective Study

    Science.gov (United States)

    Hwang, Sean-Shong; Cao, Yue; Xi, Juan

    2011-01-01

    The aim of this study is to measure the short-term impact of involuntary migration resulting from China's Three Gorges Dam project on the 1.3 million persons being displaced. We focus on the social, economic, and mental and physical health impact using three sets of indicators. Using a prospective research design, we gathered information about…

  5. Psychological and Behavioral Risk Factors for Obesity Onset in Adolescent Girls: A Prospective Study

    Science.gov (United States)

    Stice, Eric; Presnell, Katherine; Shaw, Heather; Rohde, Paul

    2005-01-01

    Because little is known about risk factors for obesity, the authors tested whether certain psychological and behavioral variables predicted future onset of obesity. The authors used data from a prospective study of 496 adolescent girls who completed a baseline assessment at age 11-15 years and 4 annual follow-ups. Self-reported dietary restraint,…

  6. The magic and menace of metagenomics: prospects for the study of plant growth-promoting rhizobacteria

    NARCIS (Netherlands)

    Leveau, J.H.J.

    2007-01-01

    This article aims to be a pragmatic primer into the field of metagenomics with special emphasis on the prospective contributions of metagenomics to the study of plant growth-promoting rhizobacteria (PGPR). After an introduction into the concepts and methodologies of metagenomics and a discussion of

  7. Arthritis in adults with community-acquired bacterial meningitis: a prospective cohort study

    NARCIS (Netherlands)

    M. Weisfelt; D. van de Beek; L. Spanjaard; J. de Gans

    2006-01-01

    Background: Although the coexistence of bacterial meningitis and arthritis has been noted in several studies, it remains unclear how often both conditions occur simultaneously. Methods: We evaluated the presence of arthritis in a prospective nationwide cohort of 696 episodes of community-acquired ba

  8. A prospective study of plasma exchange in the treatment of diffuse scleroderma.

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    A prospective randomized study to compare the efficacy between plasma exchange (PE) plus Dpenicillamine (13 cases) (group Ⅰ)and D-penicillamine alone (16 cases) (group Ⅱ) in the treatment of diffuse scleroderma was carried out. Total skin score, the distance between finger and palm the distance between

  9. Prospective study of exposure to environmental tobacco smoke and dysmenorrhea.

    OpenAIRE

    Chen, C.; Cho, S. I.; Damokosh, A I; Chen, D.; Li, G.; Wang, X.; Xu, X.

    2000-01-01

    Dysmenorrhea is a common gynecologic disorder in women of reproductive age. Previous studies have found an association between current cigarette smoking and prevalence of dysmenorrhea. This study investigated the association between exposure to environmental tobacco smoke (ETS) and the occurrence of dysmenorrhea among women without a history of this disorder. The study population consisted of 165 newly wed, nonsmoking Chinese women (in Shenyang, China), who intended to get pregnant and who ha...

  10. A prospective study on geriatric abdominal surgical emergencies

    OpenAIRE

    Deepak R. Chavan; Shailesh Kannur; B. B. Metan; Girish Kullolli

    2014-01-01

    Background: Geriatric population is a special subgroup of population undergoing emergency abdominal surgeries. Both higher age group and emergency surgical procedure are considered as high risk factors. In this study, we study the most common cause for geriatric population to undergo an emergency abdominal surgery and the therapeutic outcomes. Methods: All the patients aged more than 60 years coming to surgical department, BLDEU's hospital with acute abdominal conditions. Study period was ...

  11. Serum Taurine and Stroke Risk in Women: A Prospective, Nested Case-Control Study

    OpenAIRE

    Fen Wu; Koenig, Karen L; Anne Zeleniuch-Jacquotte; Saran Jonas; Yelena Afanasyeva; Wójcik, Oktawia P.; Max Costa; Yu Chen

    2016-01-01

    Background Taurine (2-aminoethanesulfonic acid), a conditionally essential sulfur-containing amino acid, is mainly obtained from diet in humans. Experimental studies have shown that taurine’s main biological actions include bile salt conjugation, blood pressure regulation, anti-oxidation, and anti-inflammation. Methods We conducted a prospective case-control study nested in the New York University Women’s Health Study, a cohort study involving 14,274 women enrolled since 1985. Taurine was mea...

  12. Effect of cold spells and their modifiers on cardiovascular disease events: evidence from two prospective studies

    OpenAIRE

    Sartini, Claudio; Barry, Sarah J. E.; Wannamethee, S Goya; Whincup, Peter H.; Lennon, Lucy; Ford, Ian; Morris, Richard W.

    2016-01-01

    Objective: To investigate effects of cold weather spells on incidence of cardiovascular disease (CVD), and potential effect modification of socio-demographic, clinical, behavioural and environmental exposures. Methods: Data from two prospective studies were analysed: the British Regional Heart Study (BRHS), a population-based study of British men aged 60–79 years, followed for CVD incidence from 1998–2000 to 2012; and the PROSPER study of men and women aged 70–82 recruited to a tr...

  13. Effect of cold spells and their modifiers on cardiovascular disease events: evidence from two prospective studies

    OpenAIRE

    Sartini, C.; Barry, S.J.E.; Wannamethee, S. G.; Whincup, P H; Lennon, L; Ford, I; Morris, R W

    2016-01-01

    Objective: To investigate effects of cold weather spells on incidence of cardiovascular disease (CVD), and potential effect modification of socio-demographic, clinical, behavioural and environmental exposures. / Methods: Data from two prospective studies were analysed: the British Regional Heart Study (BRHS), a population-based study of British men aged 60–79 years, followed for CVD incidence from 1998–2000 to 2012; and the PROSPER study of men and women aged 70–82 recruited to a trial of pra...

  14. A prospective study of nutritional status of hospitalised patients in urban corporate set up

    OpenAIRE

    Vijetha, B. V.; Mehra, Shikha; Swarupa, K.; Lakshman, K.

    2009-01-01

    Malnutrition is quite common in hospitalised patients, with most studies indicating a prevalence of 20–62%. It is associated with length of stay and morbidity in developed countries. This study was performed to identify nutritional status of hospitalised patients in urban corporate setting by using primarily, the Mini Nutritional Assessment tool. This is a prospective study conducted in an urban tertiary care centre. 304 consecutive patients admitted to the hospital were studied, between the ...

  15. Validation of the automatic image analyser to assess retinal vessel calibre (ALTAIR): a prospective study protocol

    OpenAIRE

    Garcia-Ortiz, Luis; Gómez-Marcos, Manuel A.; Recio-Rodríguez, Jose I; Maderuelo-Fernández, Jose A; Chamoso-Santos, Pablo; Rodríguez-González, Sara; de Paz-Santana, Juan F; Merchan-Cifuentes, Miguel A; Corchado-Rodríguez, Juan M

    2014-01-01

    Introduction The fundus examination is a non-invasive evaluation of the microcirculation of the retina. The aim of the present study is to develop and validate (reliability and validity) the ALTAIR software platform (Automatic image analyser to assess retinal vessel calibre) in order to analyse its utility in different clinical environments. Methods and analysis A cross-sectional study in the first phase and a prospective observational study in the second with 4 years of follow-up. The study ...

  16. Prospective study of ankle and foot fractures in elderly women

    Directory of Open Access Journals (Sweden)

    Yadagiri Surender Rao

    2015-01-01

    Full Text Available The epidemiology of ankle fractures in old people is changing as time passes on. The incidence of ankle fractures increases with advancing age. The study conducted was among a rural popula-tion which comprised of 68 women (32 women with ankle fractures & 36 women with foot fractures. Patients studied were in the age group more than 50 years. The study highlights the etiological & risk factors for fractures of ankle & foot. The commonest ankle fracture was the lateral malleolar fracture & the commonest foot fracture was the 5th Metatarsal fracture. Diabetes is a risk factor which increases the occurrence of ankle and foot injuries.

  17. DIAGNOSIS AND MANAGEMENT OF SUBACUTE INTESTINAL OBSTRUCTION: A PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Amit

    2014-06-01

    Full Text Available Intestinal obstruction can be defined as impairment to the abnormal passage of intestinal contents that may be due to either mechanical obstruction or failure of normal intestinal motility in the absence of an obstructing lesion. Intestinal obstruction is the most common surgical disorder of the small intestine. SAIO implies incomplete obstruction. It has been defined in a number of ways and there are many gray zones in the treatment protocols. It is characterized by continued passage of flatus and/or feces beyond 6-12 hrs. after onset of symptoms namely colicky abdominal pain, vomiting, and abdominal distension. The study was taken by considering the following aims and objectives: To study the clinical profile and clinical features of patients presenting with subacute intestinal obstruction (SAIO. To study the role of investigations in diagnosis of SAIO. To find out the underlying cause of SAIO in patients under study.

  18. Methadone and perinatal outcomes: a prospective cohort study.

    LENUS (Irish Health Repository)

    Cleary, Brian J

    2012-08-01

      Methadone use in pregnancy has been associated with adverse perinatal outcomes and neonatal abstinence syndrome (NAS). This study aimed to examine perinatal outcomes and NAS in relation to (i) concomitant drug use and (ii) methadone dose.

  19. An ecological approach to prospective and retrospective timing of long durations: a study involving gamers.

    Directory of Open Access Journals (Sweden)

    Simon Tobin

    Full Text Available To date, most studies comparing prospective and retrospective timing have failed to use long durations and tasks with a certain degree of ecological validity. The present study assessed the effect of the timing paradigm on playing video games in a "naturalistic environment" (gaming centers. In addition, as it involved gamers, it provided an opportunity to examine the effect of gaming profile on time estimation. A total of 116 participants were asked to estimate prospectively or retrospectively a video game session lasting 12, 35 or 58 minutes. The results indicate that time is perceived as longer in the prospective paradigm than in the retrospective one, although the variability of estimates is the same. Moreover, the 12-minute session was perceived as longer, proportionally, than the 35- and 58-minute sessions. The study also revealed that the number of hours participants spent playing video games per week was a significant predictor of time estimates. To account for the main findings, the differences between prospective and retrospective timing are discussed in quantitative terms using a proposed theoretical framework, which states that both paradigms use the same cognitive processes, but in different proportions. Finally, the hypothesis that gamers play more because they underestimate time is also discussed.

  20. Effects of aversive stimuli on prospective memory. An event-related fMRI study.

    Directory of Open Access Journals (Sweden)

    Massimiliano Rea

    Full Text Available Prospective memory (PM describes the ability to execute a previously planned action at the appropriate point in time. Although behavioral studies clearly showed that prospective memory performance is affected by the emotional significance attributed to the intended action, no study so far investigated the brain mechanisms subserving the modulatory effect of emotional salience on PM performance. The general aim of the present study was to explore brain regions involved in prospective memory processes when PM cues are associated with emotional stimuli. In particular, based on the hypothesised critical role of the prefrontal cortex in prospective memory in the presence of emotionally salient stimuli, we expected a stronger involvement of aPFC when the retrieval and execution of the intended action is cued by an aversive stimulus. To this aim BOLD responses of PM trials cued by aversive facial expressions were compared to PM trials cued by neutral facial expressions. Whole brain analysis showed that PM task cued by aversive stimuli is differentially associated with activity in the right lateral prefrontal area (BA 10 and in the left caudate nucleus. Moreover a temporal shift between the response of the caudate nucleus that preceded that of aPFC was observed. These findings suggest that the caudate nucleus might provide an early analysis of the affective properties of the stimuli, whereas the anterior lateral prefrontal cortex (BA10 would be involved in a slower and more deliberative analysis to guide goal-directed behaviour.

  1. Do affective attitudes predict organ donor registration? A prospective study

    OpenAIRE

    Shepherd, Lee; O'Carroll, Ronan

    2014-01-01

    This study assessed whether people's affective attitudes predicted organ donor registration at a later time. People who were not registered as an organ donor prior to completing the study (N = 150) first rated their affective attitudes towards organ donation. We then measured whether they clicked on a hyperlink to register as an organ donor. Believing that the body should be kept whole for burial (bodily integrity) was the only affective attitude to predict this organ donation behaviour. Futu...

  2. Causes of anorexia in untreated hyperthyroidism: a prospective study

    OpenAIRE

    Dai, W.; Meng, X

    2000-01-01

    Seventeen consecutive patients (mean (SD) 46 (11) years) with untreated hyperthyroidism and anorexia and 29 patients (35 (9) years) with untreated hyperthyroidism without anorexia were studied. The study was conducted at the thyroid clinic of the PUMC Hospital, Beijing, China from March to August 1997. The patients' ages, serum free calcium, liver function and emotional state, specifically the level of anxiety (using the self anxiety scale, Chinese version), were compared before and/or after ...

  3. Prospective, Controlled, Multicentre Study of Loperimide in Pregnancy

    Directory of Open Access Journals (Sweden)

    A Einarson

    2000-01-01

    Full Text Available BACKGROUND: Loperamide is a synthetic piperidine derivative used for the treatment of both acute and chronic diarrhea. Little is known about its safety and risk in pregnancy. Human data are limited to one surveillance study of Michigan Medicaid patients, with 108 women exposed in the first trimester. In this study there were six major birth defects, three of which were cardiovascular anomalies.

  4. Diet and kwashiorkor: a prospective study from rural DR Congo

    OpenAIRE

    Hallgeir Kismul; Jan Van den Broeck; Torleif Markussen Lunde

    2014-01-01

    The etiology of kwashiorkor remains enigmatic and longitudinal studies examining potential causes of kwashiorkor are scarce. Using historical, longitudinal study data from the rural area of Bwamanda, Democratic Republic of Congo, we investigated the potential causal association between diet and the development of kwashiorkor in 5 657 preschool children followed 3-monthly during 15 months. We compared dietary risk factors for kwashiorkor with those of marasmus. Kwashiorkor was diagnosed as pit...

  5. [Plant hydroponics and its application prospect in medicinal plants study].

    Science.gov (United States)

    Zeng, Yan; Guo, Lan-Ping; Huang, Lu-Qi; Sun, Yu-Zhang

    2007-03-01

    This article introduced the theorem and method of hydroponics. Some examples of studies in agriculture and forestry were presented, the effects of elements, environmental stress and hormones on physiology of medicinal plants by using hydroponics were analyzed. It also introduced the feasibility and advantage of hydroponics in intermediate propagation and allelopathy of medicinal plant. And finally it made the conclusion that the way of hydroponics would be widely used in medicinal plant study.

  6. Prospects for the study of evolution in the deep biosphere

    Directory of Open Access Journals (Sweden)

    Jennifer F Biddle

    2012-01-01

    Full Text Available Since the days of Darwin, scientists have used the framework of the theory of evolution to explore the interconnectedness of life on Earth and adaptation of organisms to the ever-changing environment. The advent of molecular biology has advanced and accelerated the study of evolution by allowing direct examination of the genetic material that ultimately determines the phenotypes upon which selection acts. The study of evolution has been furthered through examination of microbial evolution, with large population numbers, short generation times and easily extractable DNA. Such work has spawned the study of microbial biogeography, with the realization that concepts developed in population genetics may be applicable to microbial genomes (Manhes et al. 2011, Martiny et al. 2006. Microbial biogeography and adaptation has been examined in many different environments. Here we argue that the deep biosphere is a unique environment for the study of evolution and list specific factors that can be considered and where the studies may be performed. This publication is the result of the NSF-funded Center for Dark Energy Biosphere Investigations (C-DEBI theme team on Evolution (www.darkenergybiosphere.org.

  7. Prospects for the study of evolution in the deep biosphere.

    Science.gov (United States)

    Biddle, Jennifer F; Sylvan, Jason B; Brazelton, William J; Tully, Benjamin J; Edwards, Katrina J; Moyer, Craig L; Heidelberg, John F; Nelson, William C

    2011-01-01

    Since the days of Darwin, scientists have used the framework of the theory of evolution to explore the interconnectedness of life on Earth and adaptation of organisms to the ever-changing environment. The advent of molecular biology has advanced and accelerated the study of evolution by allowing direct examination of the genetic material that ultimately determines the phenotypes upon which selection acts. The study of evolution has been furthered through examination of microbial evolution, with large population numbers, short generation times, and easily extractable DNA. Such work has spawned the study of microbial biogeography, with the realization that concepts developed in population genetics may be applicable to microbial genomes (Martiny et al., 2006; Manhes and Velicer, 2011). Microbial biogeography and adaptation has been examined in many different environments. Here we argue that the deep biosphere is a unique environment for the study of evolution and list specific factors that can be considered and where the studies may be performed. This publication is the result of the NSF-funded Center for Dark Energy Biosphere Investigations (C-DEBI) theme team on Evolution (www.darkenergybiosphere.org).

  8. Status and prospects of frozen soil studies using CT technology

    Institute of Scientific and Technical Information of China (English)

    ShiJie Chen; ShuPing Zhao; Wei Ma; QianTao Zhu; LiLi Xing

    2014-01-01

    This paper introduces the characteristics of Computed Tomography (CT) technology and reviews its history, current situation, representative achievements, and use of using CT technology on frozen soil study, including auxiliary equipment specially de-signed for frozen soil studies. CT numbers are used to analyze frozen soil internal structure change, defining and exploring dam-age evolution, and use of CT images on observing soil mesostructure. Finally, this paper presents existing problems confronted by using CT in frozen soil studies, possible solutions and challenges, among which, we introduce high quality CT image processing for frozen soils, and relations between CT number change and each component change on frozen soil samples within the region of interest. It is shown that present CT technology is one of the most ideal and effective technology to study frozen soil mesostructure using non-destructive testing. CT technology will play a key role in the study and development in the field of frozen soil by means of auxiliary equipment and the digital imaging processing.

  9. A PROSPECTIVE STUDY OF ELECTROCARDIOGRAPHIC CHANGES IN COPD

    Directory of Open Access Journals (Sweden)

    Jimnaz

    2014-05-01

    Full Text Available OBJECTIVES OF STUDY: To study the electrocardiographic findings in Chronic obstructive pulmonary disease. To correlate these findings with duration, severity of the disease and pulmonary function test. MATERIALS AND METHODS: This study consists of 50 patients selected randomly from the cases admitted in the medical wards with symptoms suggestive of airway obstruction of more than 2 years duration, and in whom clinical diagnosis of chronic obstructive pulmonary disease was made. All these patients were subjected to Spirometric tests, the values of forced expiratory volume in first second (FEV1 less than 80% of the expected value, which does not alter significantly after bronchodilator inhalation (<200ml were included in this study. The cases like Bronchial asthma, Pulmonary tuberculosis, Bronchiectasis, Cor pulmonale in failure, Cardiac illness, hypertension, and diabetes mellitus were excluded from the study. RESULT: 50 patients of chronic obstructive pulmonary disease were studied Majority of patient had moderate airflow obstruction. The commonest ECG changes were P wave axis ≥+900, QRS axis ≥ + 90and P wave height in L2 ≥ 2.5mm. R wave in V6 < 5 mm and R/S ratio in V5 V6 ≤1 were seen less commonly. Unifocal right ventricular ectopics and RBBB were seen rarely. CONCLUSION: E.C.G. changes correlate significantly with low value of FEV1/FVC ratio. The commonest ECG changes were P wave axis ≥+900, QRS axis ≥ + 90 and P wave height in L2 ≥2.5mm. R wave in V6 <5 mm and R/S ratio in V5 V6 ≤1 were seen less commonly. Unifocal right ventricular ectopics and RBBB were seen rarely.

  10. PROSPECTIVE STUDY OF CYTO HISTOPATHOLOGICAL CORRELATION OF BREAST LESIONS

    Directory of Open Access Journals (Sweden)

    Vijayabharathi

    2015-06-01

    Full Text Available INTRODUCTION: Cancer of breast is the second most common cause of cancer in women. In the present era, late marriage, late child birth, shorter period of breast feeding and nulliparity or low parity have contributed to increase in the number of cases. Fine needle aspiration cytology (FNAC is a useful method for initial evaluation and diagnosis of breast cancers and it has the ability of providing necessary prognostic predictive information. AIMS AND OBJECTIVES: The aim of the present study is to evaluate t he accuracy of FNAC of breast lesions with histopathological correlation. To study the cytomorphological features of palpable breast lumps. To study the various cytological patterns in aspirates from breast lesions and to classify them into non - neoplastic, benign and malignant lesions. To correlate the cytology findings with subsequent histopathological diagnosis wherever possible. To establish accuracy and efficacy of aspiration cytology as an early and preoperative diagnostic aid. To compare the statistic al analysis of present study with other contemporary studies. MATERIALS AND METHODS: The present study includes the study of aspiration smears of all cases referred to the Department of Pathology, Andhra medical college, Visakhapatnam from various outpatient departments from King George Hospital, with a palpable breast lesion. True cut Biopsy and Mastectomy specimens for Histopathological correlation RESULTS: Out of 952 analyzed cases benign lesions were 691 (72.58%, malignant lesions were 146 (15. 33%,non - neoplastic lesions were common in the age group of 21 - 30 years, benign lesions in 21 - 30 years, and malignant lesions were common in the age group of 41 - 50 years. Majority of the patients were female with 913 (95.90% and male patents are 39 (4 .09%.The results of sensitivity (97.18%, specificity (98.74%, positive predictive value (97.18% and negative predictive value (98.74% with diagnostic accuracy of 98.26%. CONCLUSION: FNAC

  11. Swarna Bhasma in cancer: A prospective clinical study.

    Science.gov (United States)

    Das, Soumen; Das, Mangal C; Paul, Retina

    2012-07-01

    Despite the advances in the treatment of cancer, mortality is still high. Complementary and alternative medicine is emerging as a potent modality in cancer treatment. 'Swarna Bhasma' (SB), containing gold particles, is an ancient Indian medicine has shown its anticancer activity. This present study was conducted to detect the effect of SB on solid malignancies. A total of 43 patients were included in this study received SB for 1 year. Seventeen patients showed response. The response was best in rectal cancer group 70% (7/10). Nearly 41.02% patients survived for 1 year after treatment but after 5 years this came down to 15.38%.

  12. Extrapyramidal Symptoms During Risperidone Maintenance Treatment in Schizophrenia: A Prospective, Multicenter Study.

    Science.gov (United States)

    Bo, Qi-Jing; Li, Xian-Bin; Wang, Zhi-Min; Li, An-Ning; Ma, Xin; Wang, Chuan-Yue

    2016-04-01

    The risperidone maintenance treatment in schizophrenia study was designed to identify the duration of maintenance treatment required with an initial therapeutic dose in contrast to reducing the dose over time. This study investigated extrapyramidal symptoms (EPSs) in different risperidone maintenance treatment paradigms over 1 year. Clinically stabilized patients with schizophrenia (n = 374) were randomized to a no-dose-reduction group and 4-week and 26-week reduction groups, in which the dose was gradually reduced by 50% over 8 weeks and maintained. Extrapyramidal symptoms were assessed at baseline and monthly for 6 months, followed by every 2 months. The Simpson-Angus Scale of Extrapyramidal Symptoms-Chinese version assessed EPS severity. Data were analyzed by a generalized linear mixed model (GLMM). The frequency of EPS at baseline was 23.2%, 20.0%, and 21.3% in the 4-week, 26-week, and no-dose-reduction groups, respectively. Risperidone dosage, positive symptoms, and disorganized thoughts at baseline predicted development of EPS. The GLMM indicated that a significant decrease in EPS was maintained, and different trajectories occurred over time across groups. In the 235 patients who continued treatment after 1 year, the incidence of EPS decreased to 4.1%, 2.8%, and 10.0% in the 4-week, 26-week, and no-dose-reduction groups, respectively, whereas the numbers of dropouts because of intolerable EPS were not significantly different (4.8%, 6.7%, and 6.2%, respectively). These novel findings indicate EPSs were tolerable and differentially decreased depending on the dose paradigm during the 1-year treatment period. Future studies should implement a GLMM to investigate antipsychotic adverse effects during long-term treatment. PMID:26848792

  13. Social ties and risk for cancer - a prospective cohort study

    DEFF Research Database (Denmark)

    Bergelt, C.; Prescott, E.; Gronbaek, M.;

    2009-01-01

    Background. Poor social support and small social networks have been associated with increased risks for conditions such as coronary heart disease as well as with overall mortality. We investigated the association between social ties and risk for cancer. Material and methods. The study sample cons...

  14. Relationship between mechanical sensitivity and postamputation pain: A prospective study

    DEFF Research Database (Denmark)

    Nikolajsen, Lone; IlKjær, Susanne; Jensen, Troels Staehelin

    2000-01-01

    Limb amputation is followed by stump and phantom pain in a large proportion of amputees and postamputation pain may be associated with signs of hyperexcitability such as hyperalgesia to mechanical stimulation. The present study examined the possible relationship between mechanical pain threshold...

  15. Preschool Predictors of Childhood Anxiety Disorders: A Prospective Community Study

    Science.gov (United States)

    Wichstrøm, Lars; Belsky, Jay; Berg-Nielsen, Turid Suzanne

    2013-01-01

    Background: Anxiety disorders are often present at preschool age. Research on older children and studies contrasting preschoolers with high versus low behavioral inhibition (BI) highlight several risk factors, but these have not been investigated in community samples of young children. Child, parent, and peer factors at age 4 were therefore…

  16. Prospective study of bone marrow in haematological disorders

    Directory of Open Access Journals (Sweden)

    Bhagya Lakshmi Atla

    2015-08-01

    Conclusion: The present study showed the usefulness of bone marrow aspiration and trephine biopsy in evaluation of the bone marrow in routine haematological disorders and also for understanding disease progression, for diagnosis and therapeutic evaluation. These are also helpful in planning further investigation and management. [Int J Res Med Sci 2015; 3(8.000: 1917-1921

  17. Work schedules and fatigue: a prospective cohort study

    OpenAIRE

    Jansen, N; van Amelsvoort, L G P M; Kristensen, T; van den Brandt, P.A.; Kant, I.

    2003-01-01

    Aims: (1) To describe the prevalence of fatigue among employees in different work schedules (day work, three-shift, five-shift, and irregular shift work); (2) to investigate whether different work schedules are related to increasing fatigue over time, while taking into account job title and job characteristics; and (3) to study fatigue among shift workers changing to day work.

  18. A Prospective Study of Occupation and Prostate Cancer Risk

    NARCIS (Netherlands)

    Zeegers, M.P.A.; Friesema, I.H.M.; Goldbohm, R.A.; Brandt, P.A. van den

    2004-01-01

    A wide variety of occupations has been associated with prostate cancer in previous retrospective studies. Most attention has been paid to farming, metal working, and the rubber industry. Today, these results cannot be affirmed with confidence, because many associations could be influenced by recall

  19. Prognosis of coma after therapeutic hypothermia: a prospective cohort study.

    NARCIS (Netherlands)

    Bouwes, A.; Binnekade, J.M.; Kuiper, M.A.; Bosch, F.H.; Zandstra, D.F.; Toornvliet, A.C.; Biemond, H.S.; Kors, B.M.; Koelman, J.H.; Verbeek, M.M.; Weinstein, H.C.; Hijdra, A.; Horn, J.

    2012-01-01

    OBJECTIVE: This study was designed to establish the reliability of neurologic examination, neuron-specific enolase (NSE), and median nerve somatosensory-evoked potentials (SEPs) to predict poor outcome in patients treated with mild hypothermia after cardiopulmonary resuscitation (CPR). METHODS: This

  20. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies.

    NARCIS (Netherlands)

    Whitlock, G.; Lewington, S.; Sherliker, P.; Clarke, R.; Kromhout, D.

    2009-01-01

    Background - The main associations of body-mass index (BMI) with overall and cause-specific mortality can best be assessed by long-term prospective follow-up of large numbers of people. The Prospective Studies Collaboration aimed to investigate these associations by sharing data from many studies. M

  1. Integrated Database And Knowledge Base For Genomic Prospective Cohort Study In Tohoku Medical Megabank Toward Personalized Prevention And Medicine.

    Science.gov (United States)

    Ogishima, Soichi; Takai, Takako; Shimokawa, Kazuro; Nagaie, Satoshi; Tanaka, Hiroshi; Nakaya, Jun

    2015-01-01

    The Tohoku Medical Megabank project is a national project to revitalization of the disaster area in the Tohoku region by the Great East Japan Earthquake, and have conducted large-scale prospective genome-cohort study. Along with prospective genome-cohort study, we have developed integrated database and knowledge base which will be key database for realizing personalized prevention and medicine.

  2. A Study on Prospective Science Teachers' Knowledge and Achievement Levels in Mathematical Logic in Electricity-Related Subjects

    Science.gov (United States)

    Yilmaz, Ismail

    2012-01-01

    The purpose of this case study is to reveal prospective science teachers' knowledge and achievement levels in electricity-related subjects. The data for the study were collected from 44 prospective teachers using three measurement tools. The data were then analyzed using software developed for the Probability and Possibility Calculation Statistics…

  3. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies

    DEFF Research Database (Denmark)

    NN, NN; Whitlock, Gary; Lewington, Sarah;

    2009-01-01

    BACKGROUND: The main associations of body-mass index (BMI) with overall and cause-specific mortality can best be assessed by long-term prospective follow-up of large numbers of people. The Prospective Studies Collaboration aimed to investigate these associations by sharing data from many studies....

  4. A long hangover from party drugs: residual proteomic changes in the hippocampus of rats 8 weeks after γ-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination.

    Science.gov (United States)

    van Nieuwenhuijzen, Petra S; Kashem, Mohammed A; Matsumoto, Izuru; Hunt, Glenn E; McGregor, Iain S

    2010-07-01

    3,4-Methylenedioxymethamphetamine (MDMA) and gamma-hydroxybutyrate (GHB) are popular party drugs that are used for their euphoric and prosocial effects, and sometimes in combination. Both drugs increase markers of oxidative stress in the hippocampus and can cause lasting impairments in hippocampal-dependent forms of memory. To gain further information on the biochemical mechanisms underlying these effects, the current study examined residual changes in hippocampal protein expression measured 8 weeks after chronic administration of GHB (500mg/kg), MDMA (5mg/kg) or their combination (GHB/MDMA). The drugs were administered once a day for 10 days in an environment with an elevated ambient temperature of 28 degrees C. Results showed significant changes in protein expression, relative to controls, in all three groups: MDMA and GHB given alone caused residual changes in 8 and 5 proteins respectively, while the GHB/MDMA combination significantly changed 6 proteins. The altered proteins had roles in neuroplasticity, neuroprotection, intracellular signalling and cytoskeletal function. The largest change (-4.3-fold) was seen in the MDMA group with the protein C-crk: a protein implicated in learning-related neuroplasticity. The second largest change (3.0-fold) was seen in the GHB group in Glutathione-S-transferase (GST), a protein that protects against oxidative stress. Two cytoskeletal proteins (Tubulin Folding Cofactor B and Tropomyosin-alpha-3 chain) and one plasticity related protein (Neuronal Pentraxin-1 NP1) were similarly changed in both the MDMA and the GHB groups, while two intracellular signalling proteins (alpha-soluble NSF-attachment protein and subunits of the V-type proton ATPase) were changed in both the MDMA/GHB and the MDMA groups. These results provide some insight into the molecular pathways possibly underlying the lasting cognitive deficits arising from GHB and/or MDMA use.

  5. Gastroesophageal Reflux Disease and overall and Cause-specific Mortality: A Prospective Study of 50000 Individuals

    OpenAIRE

    Islami, Farhad; Pourshams, Akram; Nasseri-Moghaddam, Siavosh; Khademi, Hooman; Poutschi, Hossein; Khoshnia, Masoud; Norouzi, Alireza; Amiriani, Taghi; Sohrabpour, Amir Ali; Aliasgari, Ali; Jafari, Elham; Semnani, Shahryar; Abnet, Christian C.; Pharaoh, Paul D.; Brennan, Paul

    2014-01-01

    BACKGROUND Only a few studies in Western countries have investigated the association between gastroesophageal reflux disease (GERD) and mortality at the general population level and they have shown mixed results. This study investigated the association between GERD symptoms and overall and cause-specific mortality in a large prospective population-based study in Golestan Province, Iran. METHODS Baseline data on frequency, onset time, and patient-perceived severity of GERD symptoms were availa...

  6. Body mass index and obstetric outcomes in Saudi Arabia: a prospective cohort study

    OpenAIRE

    El-Gilany, Abdel-Hady; Hammad, Sabry

    2010-01-01

    BACKGROUND AND OBJECTIVES: We examined the effect of body mass index in early pregnancy on pregnancy outcome since no study in Saudi Arabia has addressed this question. METHODS: This prospective cohort study involved women registered for antenatal care during the first month of pregnancy at primary health care centers in Al-Hassa, Saudi Arabia. Data was collected from records and by direct interview. RESULTS: The study included 787 women. Compared to normal weight women (n=307), overweight (n...

  7. The association between antenatal anxiety and fear of childbirth in nulliparous women: a prospective study

    OpenAIRE

    Alipour, Zahra; Lamyian, Minoor; Hajizadeh, Ebrahim; Vafaei, Maryam Agular

    2011-01-01

    BACKGROUND: This study aimed to examine the association of state and trait anxiety with fear of childbirth to explore whether there was any support for the hypothesis that state and trait anxiety are risk factors for the fear of childbirth or not. METHODS: In this prospective study, 156 pregnant women referred to the health centers of Qom. The study samples selected using simple random sampling method. Anxiety and fear of the childbirth in nulliparous women were measured using Spielberger's s...

  8. High local unemployment and increased mortality in Danish adults; results from a prospective multilevel study

    OpenAIRE

    Osler, M; Christensen, U; Lund, R; Gamborg, M; Godtfredsen, N; Prescott, E

    2003-01-01

    Methods: Prospective cohort study with record linkage to mortality and unemployment registers. Data were pooled data from two population studies conducted in Copenhagen, Denmark. The association between unemployment at parish level and mortality was examined in Cox proportional hazard analysis. A total of 15 980 men and women, aged 20–67 years and employed at 1 January 1980, were studied. All-cause mortality was followed from January 1981 to December 1998.

  9. PROSPECTIVE STUDY OF CT IN ACUTE PANCREATITIS AND ITS COMPLICATIONS

    Directory of Open Access Journals (Sweden)

    Shivanand S .

    2015-09-01

    Full Text Available Visualization of the pancreas was far better by CT than b y ultrasound. Ultrasound had certain limitation. Due to bowel gas the pancreas may not be visualized. Extra pancreatic spread of inflammation and vascular complications was not always picked up by Ultrasonography. These limitations were overcome with the u se of CT which yielded more diagnostic information in the evaluation of acute pancreatitis. CT is a confirmative investigation in diagnosis and staging of acute pancreatitis. MCTSI is a very useful tool for the screening of patients with acute pancreatitis for the classification of severity accurately and to predict the clinical outcome. OBJECTIVES OF STUDY: To determine the value of computed tomography in evaluation of early diagnosis of acute pancreatitis. To evaluate the complications using computed tom ography severity index. MATERIAL AND METHODS: The study was conducted on 100 patients with clinical suspicion of acute pancreatitis, altered biochemical parameters (Serum amylase, Serum lipase in favor of acute pancreatitis, ultrasonography suggestive of acute pancreatitis and complications known case of chronic pancreatitis with features of acute symptoms who were referred to the department of Radiodiagnosis, Basaveshwar teaching & General Hospital, Kalaburagi. Before evaluating a patient by CT imaging, i nformed consent was obtained from the patient or guardian. The patient were informed about the radiation exposure in the examination. CT was carried out using Philips 6 slice scanner. Scan was obtained with both plain and contrast study. RESULT: 100 patien ts were included in the study. 83% patients were males and 17% patients were females. Majority of patients belonged to 31 - 40 yrs. of age group. Alcohol was the most common cause of acute pancreatitis. 73 patients had positive ultrasound finding while CT wa s positive in all cases. According to, MCTSI 63 patients had moderate, 26 patients had mild and 11 patients had severe

  10. Wife Battering: a Prospective Study in Sanandaj City, Iran

    OpenAIRE

    A Ghazizadeh

    2003-01-01

    To determine the prevalence of domestic physical violence against women and its associated factors in Sanandaj city, Iran, during the year 2000, this study was conducted. Random sampling of 1000 married women resident in Sanandaj city was conducted and underwent a standard interview as well as completed a 23-part questionnaire. 15 % and 38 % of the women had been assaulted by their husbands during the past year or in their marriage, respectively between 1 and 11 or more occasions. Economic pr...

  11. Security for Future Networks : a Prospective Study of AAIs

    OpenAIRE

    Aissaoui, Hassane; URIEN, Pascal; Pujolle, Guy; Joni Da Silva, Fraga; Davi Da Silva, Böger

    2013-01-01

    The future Internet will rely heavily on virtualization and cloud networking. The project Security for Future Networks proposes the design of a framework providing secure identification and authentication, secure data transfer and secure virtualized infrastructure. In this paper, we present a comparative study should examine some models and frameworks of Identity Management (IdM). Initially, we had identified OpenID, Higgins and Shibboleth frameworks as those providing facilities that are the...

  12. Intergenerational Transmission of Relationship Aggression: A Prospective Longitudinal Study

    OpenAIRE

    Cui, Ming; Durtschi, Jared A.; Donnellan, M. Brent; Lorenz, Frederick O.; Conger, Rand D.

    2010-01-01

    The present study examined whether physical and verbal aggression in the family of origin were associated with similar patterns of aggression in young adult couples. Hypotheses were tested using a sample of 213 focal individuals who were followed from adolescence to adulthood. Results suggested that aggression in the family when focal participants were adolescents predicted aggression with romantic partners when participants were adults. The association between interparental aggression and la...

  13. Potentiometric study of antioxidant activity: development and prospects.

    Science.gov (United States)

    Ivanova, A V; Gerasimova, E L; Brainina, Kh Z

    2015-01-01

    The increasing interest in the study of the antioxidant activity of different objects is caused by an unbalance between the formation of reactive oxygen species (ROS) and the performance of the antioxidant system in humans under certain conditions, which leads to oxidative stress and pathological states of the organism. This article presents a brief critical review of the methods that are used to measure integrated antioxidant activity (AOA). It is shown that the most promising methods for measuring AOA are electrochemical ones, particularly potentiometry, as it best fits the nature of the processes causing oxidative stress. The article gives the theoretical rational for requirements that an oxidizer of antioxidants (AO) should meet. The work presents the thermodynamic grounds for the use of an earlier proposed mediator system, kinetics of chemical reactions between AO and the mediator system. In order to confirm reliability and accuracy of the results, numerous correlation studies were conducted, aiming to compare the data obtained with the use the proposed method and independent analytical methods. The article presents the results of the potentiometric study of AOA for a variety of objects, including individual antioxidant → nutritional supplements → food → blood and blood fractions.

  14. MANAGEMENT OF COMPLEX OPEN FRACTURES: A PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Satyanarayana

    2015-10-01

    Full Text Available BACKGROUND : The incidence of Open fractures is on the rise, due to the increasing Road Traffic Accidents in India. In fact accidents are the leading cause of death in young, healthy individuals now. As the number of compound fractures are flooding the outpatient departments of all the major hospitals a viable and effective strategy has to be in place to manage these patients. The various treatment options available to treat these fractures and t heir effectiveness is the basis for this study. MATERIAL & METHODS : This study was conducted by our unit, from Department of Orthopedics and Traumat ology, Osmania General Hospital /Medical College during September 2012 to September 2014. The study comprises of 40 patients who were treated during this period, the patients selected were with Compound fractures Grade III A and Grade III B of Femur , Tibia and fibula. Various modalities of fixation were used in the management of these patients depending upon the clinical condition of the patient . CONCLUSIONS : External fixation was the mainstay of these fractures. It may be a first aid procedure or a definitive treatment option. The other options like Primary Nailing, biological plating have their own ind ications . Secondary procedures do play their role in the effective management of these complex injuries. All in all the successful management of these limb / life threatening injuries lies in the initial management and early intervention , secure fixation of fractures , prevention of infection and reasonable covering of the wounds.

  15. Quality of Life after Stapled Hemorrhoidopexy: A Prospective Observational Study

    Directory of Open Access Journals (Sweden)

    Pankaj Kumar Garg

    2013-01-01

    Full Text Available Objective. The objective of the study was to assess the change in quality of life (QOL of patients undergoing stapled hemorrhoidopexy (SH using WHO Quality of Life-BREF (WHOQOL-BREF questionnaire. Methods. The study sample comprised patients with symptomatic II, III, and IV degree hemorrhoids, undergoing SH. The patients were asked to complete WHOQOL-BREF questionnaire before and one month following the surgery. Result. There were 20 patients in the study group. The postoperative pain score measured by visual analogue scale at six hours postoperatively was at 24 hours. The items in the WHOQOL-BREF had high-internal consistency or reliability as shown by high Cronbach's alpha coefficient which was 0.82 and 0.90 for pre- and postoperative questionnaires. There was significant improvement in the overall perception of QOL and health, and in physical and psychological domains. There was modest improvement in environmental domain, while no change was noted in social domain. Conclusion. SH improved the quality of life of patients treated for hemorrhoids.

  16. Prospects for Chronological Studies of Martian Rocks and Soils

    Science.gov (United States)

    Nyquist, L. E.; Shih, C-Y.; Reese, Y. D.

    2008-01-01

    Chronological information about Martian processes comes from two sources: Crater-frequency studies and laboratory studies of Martian meteorites. Each has limitations that could be overcome by studies of returned Martian rocks and soils. Chronology of Martian volcanism: The currently accepted chronology of Martian volcanic surfaces relies on crater counts for different Martian stratigraphic units [1]. However, there is a large inherent uncertainty for intermediate ages near 2 Ga ago. The effect of differing preferences for Martian cratering chronologies [1] is shown in Fig. 1. Stoeffler and Ryder [2] summarized lunar chronology, upon which Martian cratering chronology is based. Fig. 2 shows a curve fit to their data, and compares to it a corresponding lunar curve from [3]. The radiometric ages of some lunar and Martian meteorites as well as the crater-count delimiters for Martian epochs [4] also are shown for comparison to the craterfrequency curves. Scaling the Stoeffler-Ryder curve by a Mars/Moon factor of 1.55 [5] places Martian shergottite ages into the Early Amazonian to late Hesperian epochs, whereas using the lunar curve of [3] and a Mars/Moon factor 1 consigns the shergottites to the Middle-to-Late Amazonian, a less probable result. The problem is worsened if a continually decreasing cratering rate since 3 Ga ago is accepted [6]. We prefer the adjusted St ffler-Ryder curve because it gives better agreement with the meteorite ages (Fig.

  17. COMPARING STANDARD AND TOTALLY TUBELESS PCNL: A PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    L. N. Raj

    2016-07-01

    Full Text Available Percutaneous nephrolithotomy (PCNL was introduced in 1976, and rapidly evolved into the gold standard for treatment of large and complex renal stones. The procedure continues to evolve with an emphasis on maintaining a high success rate of stone treatment while improving patient outcome with decreased morbidity. With the improvement of instrumentation and experience of PCNL, several modifications to the procedure have taken place in order to reduce the morbidity & early return to normal lifestyle. First described by Wickham et al., another technical variation of tubeless PCNL is totally tubeless approach. The aim of this study is to compare standard and totally tubeless PCNL with respect to safety and efficacy. MATERIALS AND METHODS This study was performed in the Department of Urology, RajaRajeswari Medical College and Hospital, Bangalore from June 2015 to March 2016 after ethics committee clearance. Forty patients planned for PCNL and who gave informed written consent were included in the study. Patients were divided into two groups, standard PCNL (with a nephrostomy tube and totally tubeless PCNL (no ureter stents or ureteric catheters. RESULTS Both the groups were similar in terms of patient and stone characteristics. The mean operation time was slightly longer in the standard group (106.74 minutes than in the totally tubeless group (100.32 minutes, but there was no statistically significant difference. There was no significant difference between the two groups with regard to serum creatinine change or blood loss. However, hospital stay and analgesia requirement was significantly less in the totally tubeless group. CONCLUSION Totally tubeless PCNL leads to shorter hospital stays and less postoperative pain. It can be used with a favourable outcome in selected patients (stone burden <2 cm, single tract access, no significant residual stones, minimal bleeding, and no requirement for a secondary procedure.

  18. Religious Confession and Symptom Severity: A Prospective Comparative Study.

    Science.gov (United States)

    Rana, Madiha; Rana, Majeed; Herzberg, Philipp Y; Krause, Christin

    2015-12-01

    Little research has been done on comparing confessions regarding mental health. In the present study, 320 people (78 Buddhists, 77 Catholics, 89 Protestants and 79 Muslims) were compared in terms of their symptom severity. Buddhists and Protestants had lower scores than Catholics and Muslims for obsessive-compulsive behavior and hostility. Muslim group had the highest comparative scores for psychoticism. Buddhists and Protestants had comparatively low scores for paranoid ideation and overall symptom severity, with Catholics and Muslims having high ones. Results reveal that confession should be taken in account in psychological research and diagnosis, since it is explicitly associated with psychological well-being. PMID:25204789

  19. Wife Battering: a Prospective Study in Sanandaj City, Iran

    Directory of Open Access Journals (Sweden)

    A Ghazizadeh

    2003-08-01

    Full Text Available To determine the prevalence of domestic physical violence against women and its associated factors in Sanandaj city, Iran, during the year 2000, this study was conducted. Random sampling of 1000 married women resident in Sanandaj city was conducted and underwent a standard interview as well as completed a 23-part questionnaire. 15 % and 38 % of the women had been assaulted by their husbands during the past year or in their marriage, respectively between 1 and 11 or more occasions. Economic problems were the most frequent cause of domestic quarrel, while there was a significant association between the husband’s educational level and the violence against their wives (P=0.001.The physical violence against housewives was significantly more frequent than the employed ones .The husbands job was also significantly associated with their violence The existence of child or daughter in the family had a preventive role in domestic physical violence against women. Logit Regression Model for prediction of physical violence against women (Y during the marriage was: "Y=0.014- 0.029 woman’s age +0.199 numbers of children -0.238 man’s education +0.589 woman’s job ". This study confirms for Sanandaj city of Iran, the high frequency of physical violence against women by their husbands. Cultural education and supportive measures are essential to control that. Screening protocol for the detection of domestic violence in family planning Health Care System is recommended.

  20. Helminthic infestation in children of Kupwara district: A prospective study

    Directory of Open Access Journals (Sweden)

    Wani S

    2007-01-01

    Full Text Available The present study deals with the investigation of the frequency of intestinal helminth parasites in children of Kupwara, Kashmir, India. Three hundred and twelve children in the age group of 4-15 years were examined for different intestinal helminths in three schools located in rural areas. Two hundred and twenty two of 312 (71.15% tested positive for various intestinal helminths. The various helminth parasites included Ascaris lumbricoides , Trichuris trichiura , Enterobius vermicularis and Taenia saginata . By far, the highest frequency of 69.23% (216/312 was noted for Ascaris lumbricoides followed by Trichuris trichiura 30.76% (96/312, Enterobius vermicularis 7.69% (24/312 and Taenia saginata 7.69% (24/312. Single infection was found in 33.65% (105/312 and mixed infection was seen in 37.5% (117/312 children. This study emphasizes the need for improved environmental conditions, i.e., clean water supplies, enhanced sanitation and chemotherapy of school-age children in rural areas.

  1. Bulbar dysfunction in normal pressure hydrocephalus: a prospective study.

    Science.gov (United States)

    Chankaew, Ekawut; Srirabheebhat, Prajak; Manochiopinig, Sriwimon; Witthiwej, Theerapol; Benjamin, Itsara

    2016-09-01

    OBJECTIVE Normal pressure hydrocephalus (NPH) is clinically characterized by gait disturbance, cognitive impairment, and urinary incontinence, as well as enlargement of the ventricles. To the best of the authors' knowledge, there have been no previous publications regarding the correlation between bulbar dysfunction and NPH. The primary objective of this study was to compare preoperative and postoperative prevalence of bulbar dysfunction in patients with NPH. Secondary objectives included assessing the results of surgery for swallowing, speech, gait, cognition, and urination, and evaluating the correlation between bulbar dysfunction and triad symptoms. METHODS Fifty-three patients with NPH who underwent shunt placement surgery at Siriraj Hospital were included in the study. Patients were evaluated for gait, cognition, urination, swallowing, and speech before and 6 months after shunt placement. Triad symptoms were assessed using standard methods. Bulbar dysfunctions were assessed using the Swallowing Problem Questionnaire, Thai Articulation Test, Resonation Screening Test (RST), and Thai Nasality Test. The Thai Speech Assessment Program and nasometer were used for objective speech measurement. RESULTS Preoperatively, 86% (43/50) of patients had swallowing problems and 75% (37/49) had speech problems, as measured by the RST. Postoperatively, there was significant improvement in swallowing (p management of NPH. PMID:27581311

  2. Glove failure in elective thyroid surgery: A prospective randomized study

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    Dariusz Timler

    2015-06-01

    Full Text Available Objectives: To analyze perforation rate in sterile gloves used by surgeons in the operating theatre of the Department of Endocrinological and General Surgery of Medical University of Lodz. Material and Methods: Randomized and controlled trial. This study analyses the incidents of tears in sterile surgical gloves used by surgeons during operations on 3 types of thyroid diseases according to the 10th revision of International Statistical Classification of Diseases and Related Health Problems (ICD-10 codes. Nine hundred seventy-two pairs (sets of gloves were collected from 321 surgical procedures. All gloves were tested immediately following surgery using the water leak test (EN455-1 to detect leakage. Results: Glove perforation was detected in 89 of 972 glove sets (9.2%. Statistically relevant more often glove tears occurred in operator than the 1st assistant (p < 0.001. The sites of perforation were localized mostly on the middle finger of the non-dominant hand (22.5%, and the non-dominant ring finger (17.9%. Conclusions: This study has proved that the role performed by the surgeon during the procedure (operator, 1st assistant has significant influence on the risk of glove perforations. Nearly 90% of glove perforations are unnoticed during surgery.

  3. Prospects for Pulsar Studies with the GLAST Large Area Telescope

    Science.gov (United States)

    Harding, Alice K.

    2007-01-01

    The Large Area Telescope (LAT) on the Gamma-ray Large Area Space Telescope (GLAST), due to launch in November 2007, will have unprecedented sensitivity and energy resolution for gamma-rays in the range of 30 MeV to 200 GeV. GLAST is therefore expected to provide major advances in the understanding of high-energy emission from rotation-powered pulsars. As the only presently known galactic GeV source class; pulsars will be one of the most important sources for study with GLAST. The main science goals of the LAT for pulsar studies include an increase in the number of detected radio-loud and radio-quiet gamma-ray pulsars, including millisecond pulsars, giving much better statistics for elucidating population characteristics, measurement of the high-energy spectrum and the shape of spectral cutoffs and determining pulse profiles for a variety of pulsars of different age. Further, measurement of phase-resolved spectra and energy dependent pulse profiles of the brighter pulsars should allow detailed tests of magnetospheric particle acceleration and radiation mechanisms, by comparing data with theoretical models that have been developed. Additionally, the LAT will have the sensitivity to allow blind pulsation searches of nearly all unidentified EGRET sources, to possibly uncover more radio-quiet Geminga-like pulsars.

  4. Implant-supported overdentures: a longitudinal prospective study.

    Science.gov (United States)

    Bergendal, T; Engquist, B

    1998-01-01

    The aim of this study was to evaluate the clinical function and long-term prognosis of overdentures retained by a small number of implants in the maxilla and mandible using one of two different attachment systems. Included in the study were all patients referred to specialty clinics in Jönköping and Linköping, Sweden, during the treatment period who needed an overdenture and could be provided with a minimum number of two bilaterally-placed implants. Excluded were patients with bone-grafted jaws, irradiated cancer patients, heavy bruxers, and patients who had lost a fixed prosthesis because of implant losses. The patients were randomly assigned to receive one retentive system, either a round 2-mm-diameter bar with clips or ball attachments (Nobel Biocare). Eighteen overdentures were placed in maxillae and 32 in mandibles, supported by a total of 115 Brånemark implants. Of the implants placed, 86.1% were continuously osseointegrated. The cumulative implant survival rates after 7 years of loading were 75.4% in the maxillae and 100% in the mandibles. There was no difference in implant survival rate between the attachment systems. Patients with implant losses were characterized by severely resorbed maxillary ridges and inferior bone quality, together with unfavorable loading circumstances such as short implants combined with long leverages. Complications and prosthetic adjustments were mostly resolved early and easily. PMID:9581412

  5. Diet and kwashiorkor: a prospective study from rural DR Congo

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    Hallgeir Kismul

    2014-04-01

    Full Text Available The etiology of kwashiorkor remains enigmatic and longitudinal studies examining potential causes of kwashiorkor are scarce. Using historical, longitudinal study data from the rural area of Bwamanda, Democratic Republic of Congo, we investigated the potential causal association between diet and the development of kwashiorkor in 5 657 preschool children followed 3-monthly during 15 months. We compared dietary risk factors for kwashiorkor with those of marasmus. Kwashiorkor was diagnosed as pitting oedema of the ankles; marasmus as abnormal visibility of skeletal structures and palpable wasting of the gluteus muscle. A 24-h recall was administered 3-monthly to record the consumption of the 41 locally most frequent food items. We specified Hanley–Miettinen smooth-in-time risk models containing potential causal factors, including food items, special meals prepared for the child, breastfeeding, disease status, nutritional status, birth rank, age, season and number of meals. Bayesian Information Criteria identified the most plausible causal model of why some children developed kwashiorkor. In a descriptive analysis of the diet at the last dietary assessment prior to development of kwashiorkor, the diet of children who developed kwashiorkor was characterized by low consumption of sweet potatoes, papaya and “other vegetables” [0.0% , 2.3% (95% CI [0.4, 12.1] and 2.3% (95% CI [0.4, 12.1

  6. Retinal detachment in southwest Ethiopia: a hospital based prospective study.

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    Tsedeke Asaminew

    Full Text Available PURPOSE: The incidence of retinal detachment in Blacks is generally considered to be low though there are few supporting studies in Africa. This study, thus, aimed at describing the clinical profile of patients with retinal detachment in Southwest Ethiopia. METHODS: A hospital-based study was done on all consecutive retinal detachment patients who presented to Jimma University Hospital over six months period. A semi-structured questionnaire was used to collect patients' sociodemographic characteristics and clinical history. Comprehensive anterior and posterior segment eye examinations were done and risk factors were sought for. Statistical tests were considered significant if P < 0.05. RESULTS: A total of 94 eyes of 80 patients (1.5% had retinal detachment (RD and about 69% of patients were symptomatic for over a month before presentation. The mean age was 41.4 years (SD ±16.5. Fourteen patients (17.5% had bilateral RD. At presentation, 61 eyes (64.9% were blind from RD and 11 (13.8% patients were bilaterally blind from RD. Rhegmatogenous RD was seen in 55 eyes (58.5% and tractional RD in 22 eyes (23.4%. The most common risk factors were ocular trauma (32 eyes, 34.0%, myopia (23 eyes, 24.5%, posterior uveitis (13 eyes, 13.8% and diabetic retinopathy (9 eyes, 9.6%. Most retinal breaks (25 eyes, 43.1% were superotemporal and horse-shoe tear was the most common (19 eyes, 20.2%. Macula was off in 77 eyes (81.9% and 38 eyes (69.1% of RRD eyes had grade C proliferative vitreoretinopathy (PVR. Macular status was significantly associated with PVR (P=0.011, and duration of symptoms (RR=1.25, 95%CI: 1.059-1.475, P=0.040. CONCLUSIONS: A significant numbers of patients with ocular problem had retinal detachment, and nearly two third of the patients presented late. Trauma and myopia were the most important risk factors. People should be educated to improve their health seeking behavior and use eye safety precautions to prevent ocular trauma.

  7. Retinal Detachment in Southwest Ethiopia: A Hospital Based Prospective Study

    Science.gov (United States)

    Asaminew, Tsedeke; Gelaw, Yeshigeta; Bekele, Sisay; Solomon, Berhan

    2013-01-01

    Purpose The incidence of retinal detachment in Blacks is generally considered to be low though there are few supporting studies in Africa. This study, thus, aimed at describing the clinical profile of patients with retinal detachment in Southwest Ethiopia. Methods A hospital-based study was done on all consecutive retinal detachment patients who presented to Jimma University Hospital over six months period. A semi-structured questionnaire was used to collect patients’ sociodemographic characteristics and clinical history. Comprehensive anterior and posterior segment eye examinations were done and risk factors were sought for. Statistical tests were considered significant if P < 0.05. Results A total of 94 eyes of 80 patients (1.5%) had retinal detachment (RD) and about 69% of patients were symptomatic for over a month before presentation. The mean age was 41.4 years (SD ±16.5). Fourteen patients (17.5%) had bilateral RD. At presentation, 61 eyes (64.9%) were blind from RD and 11 (13.8%) patients were bilaterally blind from RD. Rhegmatogenous RD was seen in 55 eyes (58.5%) and tractional RD in 22 eyes (23.4%). The most common risk factors were ocular trauma (32 eyes, 34.0%), myopia (23 eyes, 24.5%), posterior uveitis (13 eyes, 13.8%) and diabetic retinopathy (9 eyes, 9.6%). Most retinal breaks (25 eyes, 43.1%) were superotemporal and horse-shoe tear was the most common (19 eyes, 20.2%). Macula was off in 77 eyes (81.9%) and 38 eyes (69.1% of RRD eyes) had grade C proliferative vitreoretinopathy (PVR). Macular status was significantly associated with PVR (P=0.011), and duration of symptoms (RR=1.25, 95%CI: 1.059-1.475, P=0.040). Conclusions A significant numbers of patients with ocular problem had retinal detachment, and nearly two third of the patients presented late. Trauma and myopia were the most important risk factors. People should be educated to improve their health seeking behavior and use eye safety precautions to prevent ocular trauma. PMID:24086614

  8. Diet and kwashiorkor: a prospective study from rural DR Congo.

    Science.gov (United States)

    Kismul, Hallgeir; Van den Broeck, Jan; Lunde, Torleif Markussen

    2014-01-01

    The etiology of kwashiorkor remains enigmatic and longitudinal studies examining potential causes of kwashiorkor are scarce. Using historical, longitudinal study data from the rural area of Bwamanda, Democratic Republic of Congo, we investigated the potential causal association between diet and the development of kwashiorkor in 5 657 preschool children followed 3-monthly during 15 months. We compared dietary risk factors for kwashiorkor with those of marasmus. Kwashiorkor was diagnosed as pitting oedema of the ankles; marasmus as abnormal visibility of skeletal structures and palpable wasting of the gluteus muscle. A 24-h recall was administered 3-monthly to record the consumption of the 41 locally most frequent food items. We specified Hanley-Miettinen smooth-in-time risk models containing potential causal factors, including food items, special meals prepared for the child, breastfeeding, disease status, nutritional status, birth rank, age, season and number of meals. Bayesian Information Criteria identified the most plausible causal model of why some children developed kwashiorkor. In a descriptive analysis of the diet at the last dietary assessment prior to development of kwashiorkor, the diet of children who developed kwashiorkor was characterized by low consumption of sweet potatoes, papaya and "other vegetables" [0.0% , 2.3% (95% CI [0.4, 12.1]) and 2.3% (95% CI [0.4, 12.1])] in comparison with children who did not develop kwashiorkor [6.8% (95% CI [6.4, 7.2]), 15.5% (95% CI [15, 16.1]) and 15.1% (95% CI [14.6, 15.7])] or children who developed marasmus [4.5% (95% CI [2.6, 7.5]) 11.8% (95% CI [8.5, 16.0]) and 17.6% (95% CI [13.7, 22.5])]. Sweet potatoes and papayas have high β-carotene content and so may some of "the other vegetables". We found that a risk model containing an age function, length/height-for age Z-score, consumption of sweet potatoes, papaya or other vegetables, duration of this consumption and its interaction term, was the most plausible

  9. Psychosocial work environment and antidepressant medication: a prospective cohort study

    DEFF Research Database (Denmark)

    Bonde, Jens Peter; Munch-Hansen, T.; Wieclaw, J.;

    2009-01-01

    alone. None of the measured psychosocial work environment factors were consistently related to prescription of antidepressant drugs during the follow-up period. CONCLUSION: The study does not indicate that a poor psychosocial work environment among public service employees is related to prescription......BACKGROUND: Adverse psychosocial work environments may lead to impaired mental health, but it is still a matter of conjecture if demonstrated associations are causal or biased. We aimed at verifying whether poor psychosocial working climate is related to increase of redeemed subscription...... of antidepressant medication. METHODS: Information on all antidepressant drugs (AD) purchased at pharmacies from 1995 through 2006 was obtained for a cohort of 21,129 Danish public service workers that participated in work climate surveys carried out during the period 2002-2005. Individual self...

  10. Coping with a breast cancer diagnosis: a prospective study.

    Science.gov (United States)

    Stanton, A L; Snider, P R

    1993-01-01

    Employing the stress and coping theory of Lazarus and Folkman, this study followed 117 women age 40 or over regarding personality, cognitive appraisal, coping, and mood variables before breast biopsy, after diagnosis, and, for those who had cancer, after surgery. Upon biopsy, 36 received a cancer diagnosis, and 81 received a benign diagnosis. The 2 groups did not differ on appraisals, coping, or affect before diagnosis. With prebiopsy affect controlled, cancer patients reported more negative affect postbiopsy than did benign patients. Postsurgery, cancer patients expressed less vigor and more fatigue than benign patients, but the groups did not differ on other negative emotions. Prebiopsy, psychosocial predictors accounted for 54% and 29% of the variance in negative and positive emotion, respectively. Prebiopsy variables also predicted postbiopsy and postsurgery mood; cognitive avoidance coping was a particularly important predictor of high distress and low vigor.

  11. A prospective study on geriatric abdominal surgical emergencies

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    Deepak R. Chavan

    2014-06-01

    Results: 128 patients aged 60 years or more who presented with abdominal emergency surgical conditions were studied. Most common cause for emergency abdominal surgery was perforated peptic ulcer (38% followed by intestinal obstruction (17%. The most common post-operative complication was surgical site infection (29%. Mortality rate was 17%. Most common cause of death was septic shock with multi organ dysfunction. Conclusion: Geriatric population is an important subgroup of population undergoing emergency abdominal surgeries. Most common cause is peptic ulcer perforation followed by intestinal obstruction due to adhesions. More than the age per say, the delay in presentation may be the cause for mortality in this age group. The therapeutic outcome in patients with co morbid factors like hypertension and diabetes mellitus in control, were similar to other patients. [Int J Res Med Sci 2014; 2(3.000: 963-971

  12. A Prospective Study of Villous Capillary Lesions in Complicated Pregnancies

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    Anu Priyadharshini Srinivasan

    2014-01-01

    Full Text Available The vascularity of placental tissue is dependent on various factors of which fetomaternal hypoxia plays a major role. Hypoxia can be of different types and each type influences the vascularity of the villi, especially terminal villi, in its own way. In this study, we attempted to identify villous vascular changes in a group of term placentae from mothers with diseases complicating pregnancy. Chorangiosis was the most frequently identified lesion while chorangioma was found in only 2 cases. There were no cases of chorangiomatosis. A few cases had normal villous vasculature. Maternal diseases have a major role in disrupting the placental vasculogenesis and angiogenesis by creating a hypoxic environment that may affect the fetus adversely. Hence, such conditions need to be identified early in pregnancy and managed appropriately as it is possible to maintain a normal vasculature and prevent neonatal mortality and morbidity if prompt intervention is done.

  13. Ultrasound-guided transrectal extended prostate biopsy: a prospective study

    Institute of Scientific and Technical Information of China (English)

    Mohammed Ahmed Al-Ghazo; Ibrahim Fathi Ghalayini; Ismail Ibrahim Matalka

    2005-01-01

    Aim: To evaluate the diagnostic value of the 10 systematic transrectal ultrasound-guided (TRUS) prostate biopsy compared with the sextant biopsy technique for patients with suspected prostate cancer. Methods: One hundred and fifty-two patients with suspected prostate cancer were included in the study. Patients were entered in the study because they presented with high levels of prostate specific antigen (PSA) (over 4 ng/mL) and/or had undergone an abnormal digital rectal examination (DRE). In addition to sextant prostate biopsy cores, four more biopsies were obtained from the lateral peripheral zone with additional cores from each suspicious area revealed by transrectal ultrasound. Sextant, lateral peripheral zone and suspicious area biopsy cores were submitted separately to the pathological department. Results: Cancer detection rates were 27.6% (42/152) and 19.7% (30/152) for the 10-core and sextant core biopsy protocols, respectively. Adding the lateral peripheral zone (PZ) to the sextant prostate biopsy showed a 28.6% (12/42) increase in the cancer detection rate in patients with positive prostate cancer (P < 0.01).The cancer detection rate in patients who presented with elevated PSA was 29.3% (34/116). When serum PSA was 4-10 ng/mL TRUS-guided biopsy detected cancer in 20.6%, while the detection rate was 32.4% and 47.0% when serum PSA was 10-20 ng/mL and above 20 ng/mL, respectively. Conclusion: The 10 systematic TRUS-guided prostate biopsy improves the detection rate of prostate cancer by 28.6% when compared with the sextant biopsy technique alone, without increase in the morbidity. We therefore recommend the 10-core biopsy protocol to be the preferred method for early detection of prostate cancer.

  14. Possibilities of preventing traumatic dental injuries: A prospective study

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    Blagojević Duška

    2005-01-01

    Full Text Available Introduction The aim of this study was to investigate the most important etiological factors related to traumatic dental injuries, type of required treatment, period from injury to initial treatment and Frequency of recall appointments. Material and methods The sample consisted of 283 children with dental injuries managed at the Department of Dentistry of the Faculty of Medicine in Novi Sad. during the last 7 years. Retrospective data relied on trauma protocols of this department, whereas collected data referred to etiological factors, type of initial treatment, period from injury to initial treatment, recall appointments and complications of traumatic dental injuries. These results were compared with other similar national and international studies, in order to promote implementation of preventive strategies that would reduce the increasing frequency of dental trauma. Results Fall accidents were the most common cause of dental trauma. Injuries were most frequent in autumn, in the street, and in the afternoon hours. Single tooth injury was predominant, while the injured mostly denied previous injuries. Almost half of the injured patients did not seek professional help in the first 24 hours after the injury. 40% of treated patients missed their recall appointment. Conclusion Knowledge of the etiology is important for planning preventive, measures, but because of the complexity of etiological factors, it is difficult to prevent traumatic dental injuries. It is also important to underline the importance of immediate initial treatment of traumatized patients, and significance of their regular professional supervision. Generally speaking, almost all treatment procedures in management of traumatic dental injuries include preventive component.

  15. Seroprevalence of pertussis in Senegal: a prospective study.

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    Lobna Gaayeb

    Full Text Available BACKGROUND: Pertussis, also known as whooping cough, is a vaccine-preventable respiratory disease caused by Bordetella pertussis infection, against which Senegalese children are immunized with the diphtheria-tetanus-whole cell pertussis vaccine (DTwP. Seroepidemiology of pertussis has been widely described in industrialized countries, but rare are the studies referring to it in developing countries. METHODS: We conducted a longitudinal survey in Northern Senegal to investigate the epidemiology of B. pertussis by evaluating the IgG antibody (Ab response against pertussis toxin (PT. A cohort of 410 children aged 1 to 9 from five villages in the Middle Senegal River Valley were followed-up for 18 months. During that period, five visits were made to assess the immunological status of the children. PRINCIPAL FINDINGS: PT-specific IgG responses were significantly different according to age. Until the age of 3, there was a decrease in the Ab response, which then increased in the older groups. Assessment of IgG antibodies to PT (IgG-PT suggested evidence of recent exposures to the pathogen. Surprisingly, in one of the five villages the average Ab response to PT was very low at all ages during the first 6 months of the study. At the third visit, IgG-PT concentrations peaked to very high levels, to slightly decline at the end of the survey. This indicates an outbreak of B. pertussis, whereas in the other villages a pertussis endemic profile could be observed. CONCLUSIONS: Pertussis is endemic in Northern Senegal despite the introduction of vaccination. The circulation of the bacteria seems to differ between geographic locations and over time. A more complete understanding of the epidemiology of pertussis and its environmental determinants could provide information to adapt vaccination programs.

  16. Community paediatric respiratory infection surveillance study protocol: a feasibility, prospective inception cohort study

    Science.gov (United States)

    Anderson, Emma C; Ingle, Suzanne Marie; Muir, Peter; Beck, Charles; Finn, Adam; Leeming, John Peter; Cabral, Christie; Kesten, Joanna May; Hay, Alastair D

    2016-01-01

    Introduction Paediatric respiratory tract infections (RTIs) are common reasons for primary care consultations and antibiotic prescribing. Locally relevant syndromic and microbiological surveillance information has the potential to improve the care of children with RTIs by normalising illness (parents) and reducing uncertainty (clinicians). Currently, most RTI studies are conducted at the point of healthcare service consultation, leaving the community burden, microbiology, symptom duration and proportion consulting largely unknown. This study seeks to establish the feasibility of (mainly online) participant recruitment and retention, and the acceptability/comparability of parent versus nurse-collected microbiological sampling, to inform the design of a future surveillance intervention study. Evidence regarding consultation rates and symptom duration is also sought. Methods and analysis A community-based, feasibility prospective inception cohort study, recruiting children aged ≥3 months and rates. Feasibility will be assessed using recruitment and retention rates, data completeness; and acceptability by quantitative survey and qualitative interviews. Symptomatic parent and nurse swab pairs will be compared for microbe isolation. PMID:27580839

  17. Postoperative Complications Following Gingival Grafts: A Prospective Cohort Study

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    Alexandra ROMAN

    2011-12-01

    Full Text Available Aim: Treating gingival recessions (GRs is a challenge for the practitioner who must take into consideration objective clinical factors, subjective symptoms and also factors related to the patient’s expectations. The aim of this study was to evaluate the postoperative complications associated with connective tissue graft (CTG plus coronally advanced flap (CAF and free gingival graft (FGG used to cover GRs and to compare post-operative morbidities for the two groups of procedures. Material and Methods: A total of 17 patients diagnosed with Miller class 1 to 3 GRs ≥2mm were surgically treated using CTG plus CAF or FGG. When minimum 2 mm of keratinized gingiva was present apically to GR, CTG plus CAF was used. FGG was chosen to cover GRs when keratinized gingiva was absent. Post-operative complications were evaluated with a questionnaire with six questions given to the patients at 14 days follow-up visit. The study used a 1 to 10 visual analogic scale (VAS and the levels of outcomes were classified as “none to minimum” “moderate” and “very important/severe”. Results: A total of 21 procedures, 10 CTG plus CAG and 11 FGG were included in the analysis. No palatal bleeding and no severe pain or swelling were recorded. The patients experienced more pain in the grafted area than in the donor area, for both surgical techniques, with a mean value of 3.09 (1.3 standard deviation sd versus 2.27 (1.4 sd for CTG plus CAF group and of 3.7 (2.21 sd versus 2.9 (1.7 sd for FGG group, respectively. CTG plus CAF generated significantly higher scores of tumefaction than FGG, the mean values being 2.45 (0.93 sd and 4 (2.21 sd (t-value=2.12, p<0.05 respectively. Conclusion: The complications associated with the two periodontal surgical approaches seem manageable and clinically acceptable.

  18. Predictors and health-related outcomes of positive body image in adolescent girls: A prospective study.

    Science.gov (United States)

    Andrew, Rachel; Tiggemann, Marika; Clark, Levina

    2016-03-01

    This study aimed to investigate prospective predictors and health-related outcomes of positive body image in adolescent girls. In so doing, the modified acceptance model of intuitive eating was also examined longitudinally. A sample of 298 girls aged 12 to 16 years completed a questionnaire containing measures of body appreciation, potential predictors, and a range of health outcomes, at 2 time points separated by 1 year. Longitudinal change regression models showed that perceived body acceptance by others (positively), self-objectification and social comparison (negatively), and body appreciation (positively) prospectively predicted intuitive eating 1 year later, consistent with the acceptance model of intuitive eating. Perceived body acceptance by others was the only proposed predictor to prospectively predict an increase in body appreciation over time. Time 1 body appreciation prospectively predicted a decrease in dieting, alcohol, and cigarette use, and an increase in physical activity 1 year later. In particular, girls with low body appreciation were more likely than girls with high body appreciation to take up alcohol and cigarette use between time points. The results highlight body appreciation as an important target for interventions designed to prevent or delay the uptake of alcohol and cigarette consumption among girls. More broadly, they suggest that a positive body image can confer considerable benefit for adolescent girls. PMID:26727595

  19. High local unemployment and increased mortality in Danish adults; results from a prospective multilevel study

    DEFF Research Database (Denmark)

    Osler, M; Christensen, Ulla; Lund, Rikke;

    2003-01-01

    registers. Data were pooled data from two population studies conducted in Copenhagen, Denmark. The association between unemployment at parish level and mortality was examined in Cox proportional hazard analysis. A total of 15 980 men and women, aged 20-67 years and employed at 1 January 1980, were studied......AIMS: To examine the relation between unemployment rates in area of residence and all-cause mortality, taking the individuals' unemployment experience and a number of social and behavioural factors into account. METHODS: Prospective cohort study with record linkage to mortality and unemployment...... gradually with increasing age. CONCLUSION: This prospective study suggests that high local unemployment and individuals' experience of unemployment increase mortality risk, even after adjustment for other social and behavioural factors....

  20. Etiology of epilepsy a prospective study of 210 cases

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    Walter Oleschko Arruda

    1991-09-01

    Full Text Available The objective of this study was to establish the etiology of epilepsy in 210 chronic epileptics (110 female, 100 male, aged 14-82 years (34.2±13.3. Patients less than 10 years-old and alcoholism were excluded. All underwent neurological examination, routine blood tests, EEG and CT-scan. Twenty patients (10.5% were submitted to spinal tap for CSF examination. Neurological examination was abnormal in 26 (12.4%, the EEG in 68 (45.5%, and CT-scan in 93 (44.3%. According to the International Classification of Epileptic Seizures (1981, 101 (48.1% have generalized seizures, 66 (31.4% partial seizures secondarily generalized, 25 (11.8% simple partial and complex partial seizures, and 14 (6.6% generalized and partial seizures. Four patients (2.0% could not be classified. In 125 (59.5% patients the etiology was unknown. Neurocysticercosis accounted for 57 (27.1% of cases, followed by cerebrovascular disease 8 (3.8%, perinatal damage 5 (2.4%, familial epilepsy 4 (1.9%, head injury 4 (1.9%, infective 1 (0.5%, and miscelanea 6 (2.8%.

  1. A randomized, prospective study of adjunctive Ampicillin in preterm labor

    Directory of Open Access Journals (Sweden)

    Tehranian A

    1999-09-01

    Full Text Available Acute amniotic fluid infection has emerged as a possible cause of many heretofore unexplained preterm births. Our purpose was to determine the effect of ampicillin in the prolongation of pregnancies receiving tocolysis for preterm labor. A blinded, placebo-controlled, randomized trial was conducted to study ampicillin in women hospitalized for preterm labor between 24 and 37 weeks' gestation. A total of 60 patients with intact membranes and without chorioamnionitis who were receiving magnesium sulfate were screened. Thirty women with preterm labor received ampicillin, and 30 received placebos. The primary end point was prolongation of gestation. There was no difference in age of delivery (37.6±9.7 days vs 36.08±3.9 days, P=0.085 and no difference in retardation of delivery (4.7±3.1 vs 4.1±2.1, P=0.39. The mean degree of preterm delivery were 0.62±1.93 and 1.8±3.3 weeks in ampicillin and placebo groups, respectively (not significant, P>0.1. Conclusions: Ampicillin had no effect on interval to delivery or duration of pregnancy in women treated for preterm labor. So rotine clinical use of ampicillin during tocolysis should not be recommended.

  2. Radiosurgical treatment of sporadic vestibular schwannomas: A prospective cohort study

    International Nuclear Information System (INIS)

    Objective: To analyze the preliminary experience of radiosurgery for Vestibular Schwannomas at the Pontificia Universidad Catolica de Chile. Material and methods: The first 17 patients with sporadic Vestibular Schwannomas treated by radiosurgery at our institution are reported. The marginal dose used was 12 to 12.5 Gy. prescribed at the 70 or 80 isodose fine. Patients were controlled at 6, 12 and 24 months with magnetic resonance, audiometric study and clinical examination. Results: In all of the 17 patients treated a decrease tumor enhancement on MR was demonstrated. In 16 patients (94%) a pattern of central tumor necrosis was observed during the firs year Actuarial useful hearing was maintained in 62.5% at 2 year after treatment. Facial nerve function was maintained in all of the 15 patients with normal function at treatment (100%). Trigeminal function was maintained in ah of the 14 patients (100%) with previous normal trigeminal function. The mean time to return to work or normal activities was 11.5 days after treatment. Conclusions: These preliminary results are comparable with results published in the literature and reinforce the demonstrate role of radiosurgery in the management of vestibular schwannomas

  3. Studying Linguistic and Cultural Contact in Borneo: Prospects and Challenges

    Directory of Open Access Journals (Sweden)

    Antonia Soriente

    2014-11-01

    Full Text Available In the variegated landscape of languages and cultures of Borneo, the study of languages is a powerful tool to shed light on the intricate history of relations that has long been obscured by the polarization between ‘Dayak’ and ‘Malay’. This article looks at some of the features of Lebu’ Kulit Kenyah, Penan Benalui, Punan Tubu’ and Ma’ Pnaan (Punan Malinau/Segah languages to clarify the linguistic and cultural affiliations among groups that were otherwise lumped together in vague classifications. It demonstrates what is to follow: according to a number of phonological, morphological and lexical evidence, and other historical evidence, Lebu’ Kulit has to be listed among the Kayanic languages. Penan Benalui, like the other Penan languages, is not a Kenyah language, whereas Punan Tubu’, despite the alleged cultural and social similarity with other Punan groups, cannot be classified within the Penan branch nor with other Punan languages. Ma’ Pnaan or Punan Malinau/Segah is not a Punan language and is linguistically classified within the Kayanic branch of the Kayan-Kenyah subgroup.

  4. Family origin and mortality: prospective Finnish cohort study

    Directory of Open Access Journals (Sweden)

    Finnäs Fjalar

    2011-05-01

    Full Text Available Abstract Background Death rates are notably higher in eastern Finland than in western Finland, and life expectancy of Finnish speakers shorter than that of Swedish speakers. The mortality differences correspond to recent genetic mappings of the population and are prominent for causes of death that are known to be associated with genetic risk factors. Methods Using intergenerational data, we studied the impact of parental birth area on all-cause mortality risks of middle-aged men in Finland 1985-2003, assuming that geographic family origin reflects genetic predisposition to complex disorders. Relative death risks at ages 30-49 years were estimated by parental birth region and ethnicity, according to Cox regressions standardised for own education, family type at childhood, and year of birth. Results The death risk of Finnish speakers born in eastern Finland was 1.13 (95% confidence interval 1.01 to 1.26 that of Finnish speakers born in western Finland, whereas that of Swedish speakers was only 0.60 (0.52 to 0.71. In Finnish speakers, the effects of own birth area and area of residence disappeared when parental birth area was accounted for. The death risk of persons with at least one parent born in eastern Finland was 1.23 (1.09 to 1.39 that of people with both parents born in western Finland. Conclusions Parental birth area is the driving force behind the regional mortality difference in Finland. The findings highlight and give further support for the potentially important role of genetic risk factors in mortality. Close monitoring of persons' geographic and ethnic ancestry may promote public health and avoid many early deaths.

  5. Psychosocial work environment and antidepressant medication: a prospective cohort study

    Directory of Open Access Journals (Sweden)

    Westergaard-Nielsen Niels

    2009-07-01

    Full Text Available Abstract Background Adverse psychosocial work environments may lead to impaired mental health, but it is still a matter of conjecture if demonstrated associations are causal or biased. We aimed at verifying whether poor psychosocial working climate is related to increase of redeemed subscription of antidepressant medication. Methods Information on all antidepressant drugs (AD purchased at pharmacies from 1995 through 2006 was obtained for a cohort of 21,129 Danish public service workers that participated in work climate surveys carried out during the period 2002–2005. Individual self-reports of psychosocial factors at work including satisfaction with the work climate and dimensions of the job strain model were obtained by self-administered questionnaires (response rate 77,2%. Each employee was assigned the average score value for all employees at his/her managerial work unit [1094 units with an average of 18 employees (range 3–120]. The risk of first-time AD prescription during follow-up was examined according to level of satisfaction and psychosocial strain by Cox regression with adjustment for gender, age, marital status, occupational status and calendar year of the survey. Results The proportion of employees that received at least one prescription of ADs from 1995 through 2006 was 11.9% and prescriptions rose steadily from 1.50% in 1996 to the highest level 6.47% in 2006. ADs were prescribed more frequent among women, middle aged, employees with low occupational status and those living alone. None of the measured psychosocial work environment factors were consistently related to prescription of antidepressant drugs during the follow-up period. Conclusion The study does not indicate that a poor psychosocial work environment among public service employees is related to prescription of antidepressant pharmaceuticals. These findings need cautious interpretation because of lacking individual exposure assessments.

  6. SENILE DEGENERATIVE CHANGES IN ADULT LUMBAR SPINE! - A PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Garjesh Singh

    2015-11-01

    Full Text Available : BACKGROUND: Low back pain (LBP is a common presenting complaint affecting mostly middle aged and older person and traditionally considered as ageing process, but now-a-days large number of younger people are also affected by this debilitating chronic disorder. The cause of early onset of degenerative spine disease is multifactorial, but genetical predisposition plays very important role. AIMS AND OBJECTIVE: To find out association between genetic predisposition and degenerative spine disease in adult patients and to assess the pattern of MRI findings of various degenerative diseases in lumbo-sacral spine. MATERIAL AND METHOD: The present cross-sectional study had been performed among 100 selected patients in 1yr period, who presented with chief complaint of chronic low back pain. After taking detailed clinical and professional history, MRI of lumbosacral spine had been performed. Total 100 patients were divided in two groups on the basis of genetical predisposition. Prevalence and spectrum of degenerative changes were compared between both groups. RESULTS: Hundred patients of 20 to 35-year age had been selected with mean age of 27yr. Out of 100 patients; 47 were male and 53 were female. The most common degenerative findings were desiccation of disc (95% followed by disc bulge, herniation, spinal canal stenosis, ligamentum flavum hypertrophy, facet joint hypertrophy and modic changes. L4-L5 and L5- S1 were the most commonly involved spinal levels for any degenerative pathology. CONCLUSION: Good association is seen between early onset of degenerative spine disease and genetical predisposition in patients who have history of similar type degenerative spine disease in one or more first degree relatives in comparison to those patients who do not have any genetical predisposition. So it can be concluded that heredity play important role in early onset of degenerative spine disease in adults.

  7. Prospective study in 142 cases of hepatitis C virus infection

    Institute of Scientific and Technical Information of China (English)

    Wen-Mei Fan; Wan-Fu Zhu; Li-Min Yin; Lai Wei; Xiao-Yuan Xu; Hui Zhuang

    2004-01-01

    AIM: There is limited information on the natural history of HCV infection in China. We investigated the outcome of HCV infection after nine-year follow-up and the risk factors in blood donors in China in order to provide the foundation for prevention and therapy.METHODS: A total of 172 cases of HCV infection with antiHCV positive and ALT abnormality were enrolled in the archives when was screened blood in Hebei Province in 1993. In them 142 blood donors were followed up till July 2002. No antiviral treatment was applied to them during the period of infection. In the present study, anti-HCV, HCVRNA and aminotransferase were detected and genotyping was conducted by the method of restriction fragment length polymorphism(RFLP). B-type ultrasound detection was performed in all the patients. Age, sex, alcohol consumption and clinical symptoms were questioned.RESULTS: After nine years' follow-up, 10.56% (15/142)of the cases were negative for anti-HCV and 16.42% (12/134)of them were negative for HCV-RNA. The genotypes 1b,2a and 1b/2a were 91.07%, 6.25% and 2.68% respectively.Twelve cases (8.45%) were negative for both HCV RNA and anti-HCV. The rate of chronicity in this group was 83.58% (112/134), and the rate of viral spontaneous resolution was 16.42% (22/134). The mean level of ALT,AST, γ-GT in HCV RNA positive cases was significantly higher than that in HCV RNA negative cases (P<0.001).The abnormal rate of ALT and/or AST in male donors was significantly higher than that in female donors (P = 0.005).The rate of progression to liver cirrhosis from chronic hepatitis C was significantly higher in the cases of super-infection with HBV than that in the cases of single HCV infection.Overdose alcohol consumption promoted the progression to chronicity.CONCLUSION: This area (Hebei Province) has a higher rate of chronicity in HCV infection, and measures should be taken to prevent its progression to serious liver diseases,especially for patients super-infected with HCV and HBV.

  8. O9.09EFFICACY AND TOLERABILITY OF LACOSAMIDE IN PATIENTS WITH GLIOMA: A PROSPECTIVE STUDY

    OpenAIRE

    Pellerino, A.; Bertero, L.; Trevisan, E.; Magistrello, M.; R. Soffietti; Rudà, R.

    2014-01-01

    BACKGROUND: Lacosamide (LCM) has been suggested in some retrospective studies to improve seizure control as an add-on treatment in brain tumor patients. We present here the preliminary results of a prospective study focused on a cohort of patients with gliomas and active epilepsy who received LCM. METHODS: Eligibility criteria were as follows: 1) biopsy-proven grade II or III or IV gliomas according to WHO 2007; 2) persisting seizures (seizure frequency > 1 per month) despite a treatment with...

  9. Treatment outcomes in patients with multiple brain metastases: A prospective randomized study

    OpenAIRE

    Animesh Saha; Sajal Kumar Ghosh; Chhaya Roy; Priyanjit Kayal

    2014-01-01

    Context: There is controversy regarding the radiotherapeutic dose fractionation in brain metastases (bm). Aims: The aim of this study is to analyze the treatment outcomes in patients with multiple bm. Settings and Design: Prospective, randomized study. Subjects and Methods: Patients with multiple bm with Eastern Cooperative Oncology Group performance status ≤2 were included. In arm-A patient received whole brain radiotherapy (WBRT) 30 GY in 10# over 2 weeks and in arm-B patients received 20 G...

  10. Factors affecting success of intrauterine insemination: a 3 year prospective study

    OpenAIRE

    Jayakrishnan K.; Sneha Ann Abraham; Divya Nambiar

    2016-01-01

    Background: Intrauterine insemination (IUI) is the therapeutic process of placing washed spermatozoa transcervically into the uterine cavity for the treatment of infertility. The aim of this study is to analyze the variables that contribute to the success of stimulated IUI cycles. A prospective study was done to identify the most important parameters with regard to IUI success that would provide important data for predicting the success of therapy and further help in planning sub fertility tr...

  11. Major dietary patterns and risk of frailty in older adults: a prospective cohort study

    OpenAIRE

    León-Muñoz, Luz M.; García-Esquinas, Esther; López-García, Esther; Banegas, José R; Rodríguez-Artalejo, Fernando

    2015-01-01

    Background There is emerging evidence of the role of certain nutrients as risk factors for frailty. However, people eat food, rather than nutrients, and no previous study has examined the association between dietary patterns empirically derived from food consumption and the risk of frailty in older adults. Methods This is a prospective cohort study of 1,872 non-institutionalized individuals aged ≥60 years recruited between 2008 and 2010. At baseline, food consumption was obtained with a valid...

  12. Venous Thromboembolism following Elective Aesthetic Plastic Surgery: A Longitudinal Prospective Study in 1254 Patients

    OpenAIRE

    Denis Souto Valente; Lauro Aita Carvalho; Rafaela Koehler Zanella; Sibelie Valente

    2014-01-01

    Background. Venous thromboembolism (VTE) is a disorder with short-term mortality and long-term morbidity. Healthy patients submitted to elective aesthetic plastic surgeries (EAPS) have risk factors to develop VTE not well established yet. The objective of this study was to examine the incidence and risk factors for VTE in these patients. Methods. Longitudinal, prospective (minimum follow-up of 3 months), observational study. Comprehensive information on patient characteristics and surgeries p...

  13. Brain computer tomography in critically ill patients -- a prospective cohort study

    OpenAIRE

    Purmer Ilse M; van Iperen Erik P; Beenen Ludo F M; Kuiper Michael J; Binnekade Jan M; Vandertop Peter W; Schultz Marcus J; Horn Janneke

    2012-01-01

    Abstract Background Brain computer tomography (brain CT) is an important imaging tool in patients with intracranial disorders. In ICU patients, a brain CT implies an intrahospital transport which has inherent risks. The proceeds and consequences of a brain CT in a critically ill patient should outweigh these risks. The aim of this study was to critically evaluate the diagnostic and therapeutic yield of brain CT in ICU patients. Methods In a prospective observational study data were collected ...

  14. Impact of musculoskeletal pain on insomnia onset: a prospective cohort study

    OpenAIRE

    Tang, Nicole K. Y.; McBeth, John; Jordan, Kelvin P; Blagojevic-Bucknall, Milisa; Croft, Peter; Wilkie, Ross

    2014-01-01

    Objective. Pain, the most common manifestation of rheumatological conditions, is highly prevalent among older adults, with worse health outcomes found in those with co-morbid insomnia. Proactive prevention of insomnia may reduce the overall disease burden of pain and rheumatological conditions. To inform such development, this study examined the role of pain, physical limitation and reduced social participation in predicting and mediating insomnia onset. Methods. A prospective cohort study wa...

  15. Phenotypes of severe asthma among children and adolescents in Brazil: a prospective study

    OpenAIRE

    Andrade, Wenderson Clay Correia de; Lasmar, Laura Maria de Lima Belizário Facury; Ricci, Cristiane de Abreu Tonelli; Camargos, Paulo Augusto Moreira; Álvaro A Cruz

    2015-01-01

    Background The morbidity associated with severe uncontrolled asthma is disproportionately higher in low- and middle-income countries than in high-income countries. The aim of this study was to describe the phenotypic characteristics of difficult-to-treat severe asthma and treatment-resistant severe asthma in a sample of children and adolescents in Brazil. Methods This was a prospective study, conducted between 2010 and 2014, following 61 patients (6–18 years of age) who had been diagnosed wit...

  16. Occupational exposure to noise in maxillofacial operating theatres: an initial prospective study.

    Science.gov (United States)

    Tay, Brian Diaz; Prabhu, I S; Cousin, C H S; Cousin, G C S

    2016-01-01

    Exposure to excessive noise could impair surgical performance and communication, and lead to long-term hearing loss, but it is only recently that studies on occupational exposure to noise in operating theatres have been published. The aim of this prospective study was to assess mean and peak levels of noise during maxillofacial operations. We found that both were comparable to those in other surgical specialties such as orthopaedics in which power tools are used.

  17. Comparison of parenteral tramadol and epidural ropivacaine for labour analgesia: a prospective clinical study

    OpenAIRE

    Akanksha Lamba; Priya Sardana; Ramanjeet Kaur

    2016-01-01

    Background: The pain of childbirth is one of the most severe types of pain that a woman experiences in her lifetime. Adequate analgesia during labour has a positive influence on the course of labour. For labor analgesia several non-pharmacologic and pharmacologic methods are adopted. The objective of the study is to compare parenteral tramadol and epidural ropivacaine with regard to maternal and labour outcome. Methods: This prospective, comparative, interventional clinical study was condu...

  18. Nutritional status predicts preterm death in older people : a prospective cohort study

    OpenAIRE

    Söderström, Lisa; Rosenblad, Andreas; Adolfsson, Eva Thors; Saletti, Anja; Bergkvist, Leif

    2014-01-01

    Background & aims: There is an association between malnutrition and mortality. However, it is uncertain whether this association is independent of confounders. The aim of the present study was to examine whether nutritional status, defined according to the three categories in the full Mini Nutritional Assessment (MNA) instrument, is an independent predictor of preterm death in people 65 years and older. Methods: This prospective cohort study included individuals aged >= 65 years who we...

  19. Perceived work ability and turnover intentions: a prospective study among Belgian healthcare workers

    OpenAIRE

    Derycke, Hanne; Clays, Els; Vlerick, Peter; D'hoore, William; Hasselhorn, Hans Martin; Braeckman, Lutgart

    2012-01-01

    AIM: To report a study exploring prospective relations between nurses' perceived work ability and three forms of turnover intentions, respectively, intent to leave the ward, organization and profession. BACKGROUND: Turnover of nursing staff is a major challenge for healthcare settings and for healthcare in general, urging the need to improve retention. DESIGN: Survey. METHODS: Based on the longitudinal data of the Belgian sample from the European Nurses' Early Exit study, a total of 1531 heal...

  20. Ascorbic acid is lower during pregnancy in diabetic women compared to controls: A prospective study

    DEFF Research Database (Denmark)

    Juhl, B.; Lauszus, Finn; Lykkesfeldt, Jens

    2016-01-01

    Few studies have examined how vitamin C status is affected in diabetic pregnancy and no comparison between normal and diabetic pregnancies has been found. This study evaluated vitamin C status prospectively during pregnancy in women with type 1 diabetes mellitus (n=76), in non-diabetic women (n=60...... were lower in 3rd trimester compared to 1st and 2nd trimester (both ppregnancy. Umbilical cord vitamin C levels were higher than...

  1. Prevalence of exclusive breastfeeding and its determinants in first 6 months of life: A prospective study

    OpenAIRE

    Chudasama, Rajesh K; Chikitsa D. Amin; Yogesh N Parikh

    2009-01-01

    Background: Exclusive breastfeeding for first 6 months of life is recommended under Infant and Young Child Feeding practices in India. The objective of present study was to estimate the prevalence of exclusive breastfeeding during first 6 months of life of babies and to identify factors that interfere with the practice in the study area. Methods: A prospective cohort of 462 women who delivered at maternity unit of Government Medical College & Hospital, Rajkot, which is a tertiary care centre ...

  2. Mental health and aggression strategies – A prospective study of Norwegian women

    OpenAIRE

    Bø, Anniken Lervik

    2015-01-01

    Psychiatric symptoms and aggressive communication between partners tend to coexist. However, the majority of studies on the relation between couples’ aggressive communication and psychiatric disorders are cross-sectional and often report on how one partner’s aggression may affect symptoms of psychiatric disorders in the other partner, so-called partner effects of aggression. The impact of third variables notwithstanding, prospective studies is needed to disentangle potential ca...

  3. The relationship between water intake and foetal growth and preterm delivery in a prospective cohort study

    OpenAIRE

    Wright J Michael; Hoffman Caroline S; Savitz David A

    2010-01-01

    Abstract Background Interpretation of previous associations between water intake and adverse birth outcomes is challenging given that amount and type of water consumed can be non-specific markers of exposure or underlying behavioural characteristics. We examined the relationship between water intake measures and adverse birth outcomes in participants from three study sites in the United States. Methods Using a prospective cohort study, we examined daily intake of bottled, cold tap, total tap,...

  4. Medication prescribing errors in a public teaching hospital in India: A prospective study.

    OpenAIRE

    Pote S; Tiwari P; D’Cruz S

    2007-01-01

    Background: To prevent medication errors in prescribing, one needs to know their types and relative occurrence. Such errors are a great cause of concern as they have the potential to cause patient harm. The aim of this study was to determine the nature and types of medication prescribing errors in an Indian setting.Methods: The medication errors were analyzed in a prospective observational study conducted in 3 medical wards of a public teaching hospital in India. The medication errors were an...

  5. Gestational influenza and risk of hypomania in young adulthood: prospective birth cohort study

    OpenAIRE

    Anderson, Jana J; Hoath, Sean; Zammit, Stanley; Meyer, Thomas D.; Pell, Jill P.; Mackay, Daniel; Smith, Daniel J

    2016-01-01

    BACKGROUND: Previous studies have suggested a possible link between exposure to influenza in utero and bipolar disorder in adulthood. Using data from a prospective birth cohort, we aimed to test for an association between exposure to gestational influenza and the experience of hypomania assessed in early adulthood.METHODS: We used data on 2957 participants from the Avon Longitudinal Study of Parents and Children (ALSPAC). The two main outcomes of interest were hypomania, assessed using the Hy...

  6. Do double gloves protect against contamination during cannulation of blood vessels? A prospective randomized study

    OpenAIRE

    Łukasz Szarpak; Andrzej Kurowski

    2014-01-01

    Background: Undamaged medical gloves protect medical personnel from contact with physiological fluids of the patient. Thus they protect the assistance provider from hand skin contamination with potentially infectious biological material. The aim of the study was to evaluate the occurrence of pierce, perforations or damage of medical gloves during cannulation of blood vessels. Materials and Methods: In the prospective randomized study 303 pairs of gloves, used during cannulation of blood vesse...

  7. Efficacy and Safety of Propofol Sedation During Urgent Upper Gastrointestinal Endoscopy – A Prospective Study

    OpenAIRE

    Ljubičić, Neven; Supanc, Vladimir; Roić, Goran; Sharma, Mirella

    2003-01-01

    The aim of this study was to investigate both the efficacy and safety of sedation with propofol during urgent therapeutic gastroscopy in patients with upper gastrointestinal bleeding. This prospective study included a total of 110 patients. Propofol was administered intravenously at the starting dose of 1 mg/kg body weight and was followed by repeated doses. Oxygen saturation and heart rate were monitored by pulse oxymetry. The mean dose of propofol administered was 161 49 mg....

  8. Survival of immediately versus delayed loaded short implants: a prospective case series study

    OpenAIRE

    Alvira González, Joaquín; Díaz Campos, Erick; Sánchez Garcés, María Angeles; Gay Escoda, Cosme

    2015-01-01

    Background To assess and compare survival rates of immediately and delayed loaded short implants (7 mm) in free ends of a partially edentulous jaw with moderate-severe alveolar bone resorption. Material and Methods 24 patients with atrophic edentulous free-ends were included in this prospective study. Four study groups were monitored monthly and their behavior was evaluated: bridges supported only by short implants and mixed short and long implant bridge groups, both with immediate and delaye...

  9. The Moderating Effects of Explanatory Style in Physical Education Performance: A Prospective Study

    OpenAIRE

    Martin-Krumm, Charles; Sarrazin, Philippe; Peterson, Christopher

    2005-01-01

    Explanatory style (ES) reflects the way people usually explain disparate bad or good events involving the self. The purpose of this study was twofold: (a) to test whether ES moderates the effect of perceived ability on students' expectancies and subjective task value, and (b) to explore the mediating effects of success expectancies and subjective task value in the relationships between ES and students' grades in physical education classes (GPEC). A one-year prospective study was conducted wit...

  10. Prospective Comparative Study of ACL Reconstruction Between Using Hamstring Autograft and Soft Tissue Allograft

    OpenAIRE

    Song, Eun Kyoo; Seon, Jong Keun; Kim, Hasung

    2014-01-01

    Objectives: Nowadays, two most commonly used grafts in the anterior cruciate ligament reconstruction are hamstring autograft and soft tissue allograft. Although the short-term clinical outcomes between two grafts were similar, only a few studies reported mid-term clinical outcomes. The purpose of this prospective study was to compare clinical outcomes of ACL reconstruction between using hamstring autograft and soft tissue allograft after mid-term follow-up. Methods: One-hundred sixty-one pati...

  11. Enhancing life prospects of socially vulnerable youth through sport participation: a mixed methods study

    Science.gov (United States)

    2014-01-01

    Background Sport participation has been associated with improved life prospects such as academic performance and employability prospects. As such, promoting sport participation might be a way to increase life prospects, especially for socially vulnerable youth because they are less physically active than their peers. However, the evidence for the causal effect of sport participation on these outcomes is still limited and little is known about factors that play a role in this possible effect. The aim of this study is four-fold. First, the causal effect of sport participation on life prospects is studied and the underlying mechanisms of this relation are explored. Secondly, the life experiences of the youngsters in the sport context, that may contribute to skill development, are studied. Thirdly, social conditions for a positive effect are explored, as sport is likely to have a positive effect under specific conditions. Fourthly, this study aims to provide insights on the elements of successful partnerships between youth care organisations and local sport clubs. Methods and design This protocol reports on a mixed method study. An intervention that aims to increase the sport participation of socially vulnerable youth, between 12–23 years old, is implemented in three regions of a Rotterdam youth care organisation. The youngsters in the two control regions receive care-as-usual. The main outcome variables, collected via questionnaires, are the life prospect, sense of coherence and self-regulation skills of the youngsters after 6 and 18 months of follow-up. The Motivational Climate Scale is administered to explore the social conditions for a positive effect and interviews are conducted with sport coaches to explore their role in skill development. Interviews with the youngsters are conducted to gain insight on the life experiences that may lead to skill development. The elements of successful partnerships are collected during interviews with youth care professionals

  12. Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study.

    Science.gov (United States)

    Gallo, Valentina; Vanacore, Nicola; Bueno-de-Mesquita, H Bas; Vermeulen, Roel; Brayne, Carol; Pearce, Neil; Wark, Petra A; Ward, Heather A; Ferrari, Pietro; Jenab, Mazda; Andersen, Peter M; Wennberg, Patrik; Wareham, Nicholas; Katzke, Verena; Kaaks, Rudolf; Weiderpass, Elisabete; Peeters, Petra H; Mattiello, Amalia; Pala, Valeria; Barricante, Aurelio; Chirlaque, Maria-Dolores; Travier, Noémie; Travis, Ruth C; Sanchez, Maria-Jose; Pessah-Rasmussen, Hélène; Petersson, Jesper; Tjønneland, Anne; Tumino, Rosario; Quiros, Jose Ramon; Trichopoulou, Antonia; Kyrozis, Andreas; Oikonomidou, Despoina; Masala, Giovanna; Sacerdote, Carlotta; Arriola, Larraitz; Boeing, Heiner; Vigl, Matthaeus; Claver-Chapelon, Francoise; Middleton, Lefkos; Riboli, Elio; Vineis, Paolo

    2016-03-01

    Previous case-control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included in the analysis, yielding 219 ALS deaths. At recruitment, information on PA was collected thorough standardised questionnaires. Total PA was expressed by the Cambridge Physical Activity Index (CPAI) and analysed in relation to ALS mortality, using Cox hazard models. Interactions with age, sex, and anthropometric measures were assessed. Total PA was weakly inversely associated with ALS mortality with a borderline statistically significant trend across categories (p = 0.042), with those physically active being 33 % less likely to die from ALS compared to those inactive: HR = 0.67 (95 % CI 0.42-1.06). Anthropometric measures, sex, and age did not modify the association with CPAI. The present study shows a slightly decreased-not increased like in case-control studies-risk of dying from ALS in those with high levels of total PA at enrolment. This association does not appear confounded by age, gender, anthropometry, smoking, and education. Ours was the first prospective cohort study on ALS and physical activity. PMID:26968841

  13. Uranium project. Geochemistry prospection

    International Nuclear Information System (INIS)

    Geochemistry studies the distribution of the chemicals elements in the terrestrial crust and its ways to migrate. The terminology used in this report is the following one: 1) Principles of the prospection geochemistry 2) Stages of the prospection geochemistry 3)utility of the prospection geochemistry 4) geochemistry of uranium 5) procedures used within the framework of uranium project 6) Average available 7) Selection of the zones of prospection geochemistry 8) Stages of the prospection, Sample preparation and analisis 9) Presentation of the results

  14. Nosocomial infection in a Danish Neonatal Intensive Care Unit: a prospective study

    DEFF Research Database (Denmark)

    Olsen, Anne L; Reinholdt, Jes; Jensen, Anders Mørup;

    2009-01-01

    AIM: The aim of this study was to estimate the incidence and identify independent risk factors for nosocomial infections in a Danish Neonatal Intensive Care Unit and to compare these findings with international results. METHODS: The study was performed prospectively from January 1, 2005 to December...... 31, 2005 in the Neonatal Intensive Care Unit at Rigshospitalet, Copenhagen. Specific criteria for blood stream infection and respiratory tract infection adapted for neonates in our ward were worked out. RESULTS: Six hundred and eighty-three patients were included. The overall incidence of nosocomial...... and respiratory tract infection, and central venous catheter and parenteral nutrition risk factors for first time blood stream infection. CONCLUSION: This first prospective study of nosocomial infection in a Danish Neonatal Intensive Care Unit found an overall incidence of 8.8/1000 hospital days, which is low...

  15. Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis

    NARCIS (Netherlands)

    Cooper, A.J.; Forouhi, N.G.; Ye, Z.; Buijsse, B.; Feskens, E.J.M.

    2012-01-01

    Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated meta-analysis. In the European Prospective Investigation into Cancer

  16. Coping and its effect on psychological distress of parents of pediatric cancer patients : a longitudinal prospective study

    NARCIS (Netherlands)

    Hoekstra-Weebers, Josette E. H. M.; Wijnberg-Williams, Barbara J.; Jaspers, Jan P. C.; Kamps, Willem A.; van de Wiel, Harry B. M.

    2012-01-01

    Objective This prospective 5-year longitudinal study examined the use of coping styles of fathers and mothers of pediatric cancer patients over time and the prospective effects of coping on distress. Methods Psychological distress (General Health Questionnaire) and the use of seven coping styles (Ut

  17. A prospective population study of resting heart rate and peak oxygen uptake (the HUNT Study, Norway.

    Directory of Open Access Journals (Sweden)

    Javaid Nauman

    Full Text Available OBJECTIVES: We assessed the prospective association of resting heart rate (RHR at baseline with peak oxygen uptake (VO(2peak 23 years later, and evaluated whether physical activity (PA could modify this association. BACKGROUND: Both RHR and VO(2peak are strong and independent predictors of cardiovascular morbidity and mortality. However, the association of RHR with VO(2peak and modifying effect of PA have not been prospectively assessed in population studies. METHODS: In 807 men and 810 women free from cardiovascular disease both at baseline (1984-86 and follow-up 23 years later, RHR was recorded at both occasions, and VO(2peak was measured by ergospirometry at follow-up. We used Generalized Linear Models to assess the association of baseline RHR with VO(2peak, and to study combined effects of RHR and self-reported PA on later VO(2peak. RESULTS: There was an inverse association of RHR at baseline with VO(2peak (p<0.01. Men and women with baseline RHR greater than 80 bpm had 4.6 mL.kg(-1.min(-1 (95% confidence interval [CI], 2.8 to 6.3 and 1.4 mL.kg(-1.min(-1 (95% CI, -0.4 to 3.1 lower VO(2peak at follow-up compared with men and women with RHR below 60 bpm at baseline. We found a linear association of change in RHR with VO(2peak (p=0.03, suggesting that a decrease in RHR over time is likely to be beneficial for cardiovascular fitness. Participants with low RHR and high PA at baseline had higher VO(2peak than inactive people with relatively high RHR. However, among participants with relatively high RHR and high PA at baseline, VO(2peak was similar to inactive people with relatively low RHR. CONCLUSION: RHR is an important predictor of VO(2peak, and serial assessments of RHR may provide useful and inexpensive information on cardiovascular fitness. The results suggest that high levels of PA may compensate for the lower VO(2peak associated with a high RHR.

  18. Effect of Collaborative Studies on Prospective Teachers’ Creative Thinking Skills while Designing Computer Based Material

    Directory of Open Access Journals (Sweden)

    Salih BİRİŞÇİ

    2011-06-01

    Full Text Available The purpose of this study to examine effect of collaborative studies on prospective teachers‟ creative thinking skills while designing computer based materials. One group pre-test and post-test design of the pre-experimental model was used to achieve the objectives of the study. This experimental study have been applied to 34 prospective teachers who studied at Artvin Coruh University Facult of Education Primary Education Department in 2009-2010 spring term within the context of “Computer-II” course. “Creative Thinking Skill Scale” was applied at two different stages as pre-test and post-test and opinions of students were gathered about the method in research via interview forms. As a result, it was found that there was a significant difference between the prospective teachers‟ creative thinking skills and scores taken from scale were increased in favor of post-test. Collaborative group works have a great importance in occurrence of this increase was revealed from student views.

  19. Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH: study protocol

    Directory of Open Access Journals (Sweden)

    Ennis Sarah

    2007-08-01

    Full Text Available Abstract Background Young women presenting with breast cancer are more likely to have a genetic predisposition to the disease than breast cancer patients in general. A genetic predisposition is known to increase the risk of new primary breast (and other cancers. It is unclear from the literature whether genetic status should be taken into consideration when planning adjuvant treatment in a young woman presenting with a first primary breast cancer. The primary aim of the POSH study is to establish whether genetic status influences the prognosis of primary breast cancer independently of known prognostic factors. Methods/design The study is a prospective cohort study recruiting 3,000 women aged 40 years or younger at breast cancer diagnosis; the recruiting period covers 1st June 2001 to 31st December 2007. Written informed consent is obtained at study entry. Family history and known epidemiological risk data are collected by questionnaire. Clinical information about diagnosis, treatment and clinical course is collected and blood is stored. Follow up data are collected annually after the first year. An additional recruitment category includes women aged 41 to 50 years who are found to be BRCA1 or BRCA2 gene carriers and were diagnosed with their first breast cancer during the study recruiting period. Discussion Power estimates were based on 10% of the cohort carrying a BRCA1 gene mutation. Preliminary BRCA1 and BRCA2 mutation analysis in a pilot set of study participants confirms we should have 97% power to detect a difference of 10% in event rates between gene carriers and sporadic young onset cases. Most of the recruited patients (>80% receive an anthracycline containing adjuvant chemotherapy regimen making planned analyses more straightforward.

  20. Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH): study protocol

    International Nuclear Information System (INIS)

    Young women presenting with breast cancer are more likely to have a genetic predisposition to the disease than breast cancer patients in general. A genetic predisposition is known to increase the risk of new primary breast (and other) cancers. It is unclear from the literature whether genetic status should be taken into consideration when planning adjuvant treatment in a young woman presenting with a first primary breast cancer. The primary aim of the POSH study is to establish whether genetic status influences the prognosis of primary breast cancer independently of known prognostic factors. The study is a prospective cohort study recruiting 3,000 women aged 40 years or younger at breast cancer diagnosis; the recruiting period covers 1st June 2001 to 31st December 2007. Written informed consent is obtained at study entry. Family history and known epidemiological risk data are collected by questionnaire. Clinical information about diagnosis, treatment and clinical course is collected and blood is stored. Follow up data are collected annually after the first year. An additional recruitment category includes women aged 41 to 50 years who are found to be BRCA1 or BRCA2 gene carriers and were diagnosed with their first breast cancer during the study recruiting period. Power estimates were based on 10% of the cohort carrying a BRCA1 gene mutation. Preliminary BRCA1 and BRCA2 mutation analysis in a pilot set of study participants confirms we should have 97% power to detect a difference of 10% in event rates between gene carriers and sporadic young onset cases. Most of the recruited patients (>80%) receive an anthracycline containing adjuvant chemotherapy regimen making planned analyses more straightforward

  1. Living with diabetes: rationale, study design and baseline characteristics for an Australian prospective cohort study

    Directory of Open Access Journals (Sweden)

    Donald Maria

    2012-01-01

    Full Text Available Abstract Background Diabetes mellitus is a major global public health threat. In Australia, as elsewhere, it is responsible for a sizeable portion of the overall burden of disease, and significant costs. The psychological and social impact of diabetes on individuals with the disease can be severe, and if not adequately addressed, can lead to the worsening of the overall disease picture. The Living With Diabetes Study aims to contribute to a holistic understanding of the psychological and social aspects of diabetes mellitus. Methods/Design The Living With Diabetes Study is a 5-year prospective cohort study, based in Queensland, Australia. The first wave of data, which was collected via a mailed self-report survey, was gathered in 2008, with annual collections thereafter. Measurements include: demographic, lifestyle, health and disease characteristics; quality of life (EQ-5D, ADDQoL; emotional well-being (CES-D, LOT-R, ESSI; disease self-management (PAM; and health-care utilisation and patient-assessed quality of care (PACIC. 29% of the 14,439 adults who were invited to participate in the study agreed to do so, yielding a sample size of 3,951 people. Discussion The data collected by the Living With Diabetes Study provides a good representation of Australians with diabetes to follow over time in order to better understand the natural course of the illness. The study has potential to further illuminate, and give a comprehensive picture of the psychosocial implications of living with diabetes. Data collection is ongoing.

  2. High local unemployment and increased mortality in Danish adults; results from a prospective multilevel study

    DEFF Research Database (Denmark)

    Osler, M; Christensen, U; Lund, R;

    2003-01-01

    AIMS: To examine the relation between unemployment rates in area of residence and all-cause mortality, taking the individuals' unemployment experience and a number of social and behavioural factors into account. METHODS: Prospective cohort study with record linkage to mortality and unemployment...... was also a risk factor (hazard ratio(yes/no) 1.38:1.16-1.64). These estimates attenuated somewhat when other social and behavioural covariates were taken into account. The effects were similar in men and women, but the influence of individuals' unemployment experience during one and five years decreased...... gradually with increasing age. CONCLUSION: This prospective study suggests that high local unemployment and individuals' experience of unemployment increase mortality risk, even after adjustment for other social and behavioural factors....

  3. Trunk and hip muscle recruitment patterns during the prone leg extension following a lateral ankle sprain: A prospective case study pre and post injury

    Directory of Open Access Journals (Sweden)

    Lehman Gregory J

    2006-02-01

    Full Text Available Abstract Background and case presentation The prone leg extension (PLE is commonly used to identify dysfunction of muscle recruitment patterns. The prone leg extension is theorized to identify proximal muscle disturbances which are a result of distal injury or dysfunction (i.e. an ankle sprain. This case study compares the trunk and hip muscle (bilateral lower erector spine, ipsilateral hamstring and ipsilateral gluteus maximus timing during a PLE of a 27 year old female runner during a healthy state (pre ankle sprain and 2 and 8 weeks post ankle sprain. Results and discussion The gluteus maximus muscle onsets at 8 weeks post injury appeared to occur earlier compared with 2 weeks post injury. The Right Erector Spinae at 8 weeks post injury was also active earlier compared with the participant's non-injured state. A large degree of variability can be noted within trials on the same day for all muscle groups. Conclusion An acute ankle injury did not result in a delay in gluteus maximus muscle activation. The utility of the prone leg extension as a clinical and functional test is questionable due to the normal variability seen during the test and our current inability to determine what is normal and what is dysfunctional.

  4. A Prospective Study of Dairy Consumption in Relation to Changes in Metabolic Risk Factors: The Hoorn Study

    NARCIS (Netherlands)

    Snijder, M.B.; Dam, van R.M.; Stehouwer, C.D.A.; Hiddink, G.J.; Heine, R.J.; Dekker, J.M.

    2008-01-01

    Objective: Higher dairy consumption has been suggested to reduce the risk of obesity and metabolic disturbances. The aim of our study was to investigate the prospective association between dairy consumption and changes in weight and metabolic disturbances. Methods and Procedures: Baseline dairy inta

  5. Association between -T786C NOS3 polymorphism and resistant hypertension: a prospective cohort study

    OpenAIRE

    Martín-Luengo Cándido; Sánchez-Rodríguez Angel; Sánchez-Ledesma María; Corral Esther; Cruz-González Ignacio; González-Sarmiento Rogelio

    2009-01-01

    Abstract Background It is estimated that 5% of the hypertensive patients are resistant to conventional antihypertensive therapy. Polymorphisms in the endothelial nitric oxide synthase (NOS3) gene have been associated with high blood pressure levels, but not with resistant hypertension. The aim of the present study was to investigate if the -786T>C and G894T (Glu298Asp) polymorphisms of the NOS3 gene were associated with resistant hypertension. Methods A prospective case-control observational ...

  6. Spreading of chronic pain between body regions: Prospective cohort study among health care workers

    OpenAIRE

    Andersen, LL; Clausen, T; Carneiro, IG; Holtermann, A.

    2012-01-01

    Objective To estimate the prognostic value of pain in one body region on the risk for developing chronic pain in other body regions. Methods Prospective cohort study among 5052 Danish female health care workers responding to a baseline and follow-up questionnaire in 2005 and 2006, respectively. Using adjusted logistic regression analysis, the risk for developing chronic pain (>30 days last year) at follow-up in the low back (among those without low back pain during the last year at baseline) ...

  7. Incidence of pain flare following palliative radiotherapy for symptomatic bone metastases: multicenter prospective observational study

    OpenAIRE

    Gomez-Iturriaga, Alfonso; Cacicedo, Jon; Navarro, Arturo; Morillo, Virginia; Willisch, Patricia; Carvajal, Claudia; Hortelano, Eduardo; Lopez-Guerra, Jose Luis; Illescas, Ana; Casquero, Francisco; del Hoyo, Olga; Ciervide, Raquel; Irasarri, Ana; Pijoan, Jose Ignacio; Bilbao, Pedro

    2015-01-01

    Background Palliative radiotherapy (RT) is an effective treatment for symptomatic bone metastases. Pain flare, a transient worsening of the bone pain after RT, has been described in previous reports with different incidence rates. The aim of the study was to prospectively evaluate the incidence of pain flare following RT for painful bone metastases and evaluate its effects on pain control and functionality of the patients. Methods Between June 2010 and June 2014, 204 patients were enrolled in...

  8. Association between Sleep Duration and Cancer Risk: A Meta-Analysis of Prospective Cohort Studies

    OpenAIRE

    Yan Lu; Nong Tian; Jie Yin; Yuhua Shi; Zhenping Huang

    2013-01-01

    BACKGROUND: Sleep duration has been shown to play an important role in the development of cancer. However, the results have been inconsistent. A meta-analysis with prospective cohort studies was performed to clarify the association between short or long sleep duration and cancer risk. METHODS: PubMed and Embase databases were searched for eligible publications. Pooled relative risk (RR) with 95% confidence interval (CI) was calculated using random- or fixed- model. RESULTS: A total of 10 pros...

  9. Non-alcoholic fatty liver disease and mortality among US adults: prospective cohort study

    OpenAIRE

    Lazo, Mariana; Hernaez, Ruben; Bonekamp, Susanne; Kamel, Ihab R.; Frederick L Brancati; Guallar, Eliseo; Clark, Jeanne M.

    2011-01-01

    Objective To evaluate the association between non-alcoholic fatty liver disease and all cause and cause specific mortality in a representative sample of the US general population. Design Prospective cohort study. Setting US Third National Health and Nutrition Examination Survey (NHANES III: 1988-94) with follow-up of mortality to 2006. Participants 11 371 adults aged 20-74 participating in the Third National Health and Nutrition Examination Survey, with assessment of hepatic steatosis. Main o...

  10. Prevalence of iron deficiency on ICU discharge and its relation with fatigue: a multicenter prospective study

    OpenAIRE

    Lasocki, Sigismond; Chudeau, Nicolas; Papet, Thibaut; Tartiere, Deborah; Roquilly, Antoine; Carlier, Laurence; Mimoz, Olivier; Seguin, Philippe; Malledant, Yannick; Asehnoune, Karim; Hamel, Jean François; ,

    2014-01-01

    Introduction Prevalence of iron deficiency (ID) at intensive care (ICU) admission is around 25 to 40%. Blood losses are important during ICU stay, leading to iron losses, but prevalence of ID at ICU discharge is unknown. ID has been associated with fatigue and muscular weakness, and may thus impair post-ICU rehabilitation. This study assessed ID prevalence at ICU discharge, day 28 (D28) and six months (M6) after and its relation with fatigue. Methods We conducted this prospective, multicenter...

  11. Performance evaluation of a new rapid urine test for chlamydia in men: prospective cohort study

    OpenAIRE

    Nadala, Elpidio-Cesar; Goh, Beng T; Magbanua, Jose-Paolo; Barber, Penelope; Swain, Alison; Alexander, Sarah; Laitila, Vivian; Michel, Claude-Edouard; Mahilum-Tapay, Lourdes; Ushiro-Lumb, Ines; Ison, Catherine; Lee, Helen H.

    2009-01-01

    Objective To evaluate the performance of a rapid test for chlamydia with first void male urine samples as a potential tool for diagnosis and screening of chlamydial infection in men. Design Evaluation of test performance in prospective cohort study. Settings A young people’s sexual health centre (site 1) and a genitourinary medicine clinic (site 2) in the United Kingdom. Participants 1211 men aged 16-73 attending either of the two sites. Main outcome measures Sensitivity, specificity, positiv...

  12. A prospective study of the causes of febrile illness requiring hospitalization in children in Cambodia.

    OpenAIRE

    Chheng, K; Carter, MJ; Emary, K; Chanpheaktra, N; Moore, CE; Stoesser, N.; Putchhat, H.; Sona, S; Reaksmey, S; Kitsutani, P; Sar, B.; van Doorn, HR; Uyen, NH; Tan, L.; Paris, D.

    2013-01-01

    Febrile illnesses are pre-eminent contributors to morbidity and mortality among children in South-East Asia but the causes are poorly understood. We determined the causes of fever in children hospitalised in Siem Reap province, Cambodia. A one-year prospective study of febrile children admitted to Angkor Hospital for Children, Siem Reap. Demographic, clinical, laboratory and outcome data were comprehensively analysed. Between October 12(th) 2009 and October 12(th) 2010 there were 1225 e...

  13. A Prospective, Multinational Pharmacoepidemiological Study of Clinical Conversion to Sirolimus Immunosuppression after Renal Transplantation

    OpenAIRE

    Kasiske, Bertram L.; Bjorn Nashan; Maria Del Carmen Rial; Pablo Raffaele; Graeme Russ; Josep Campistol; Pescovitz, Mark D.; Paul A Keown

    2012-01-01

    This prospective pharmacoepidemiological study examined treatment and outcomes in patients converted to sirolimus (SRL) after renal transplantation. 484 subjects in 36 centres in 7 countries were followed for up to 5 years. Principal reasons for conversion were declining graft function (146/484, 30%) and side effects of prior therapy (144/484, 30%) and the major treatment combinations after conversion were SRL ± MMF (62%), SRL + TAC (21.5%), SRL + CSA (16.5%). The cumulative probability of bi...

  14. Patient-matched instruments versus standard instrumentation in total knee arthroplasty: a prospective randomized study

    OpenAIRE

    Molicnik, Andrej; Naranda, Jakob; Dolinar, Drago

    2015-01-01

    Summary Background Optimal positioning of implants and restoration of neutral mechanical axis are two primary surgical goals in total knee arthroplasty (TKA). Despite modern instruments and improved surgical techniques, malalignment remains an important cause of early failure after TKA. The aim of this prospective randomized study was to compare the value of a new patient-matched instrument system (PMI) (SignatureTM; Biomet, Inc, Warsaw, Indiana) to that of standard TKA surgical instrumentati...

  15. Routine calcium measurement is not necessary after most thyroid surgeries: a prospective clinical study.

    LENUS (Irish Health Repository)

    Quinn, E M

    2010-12-01

    Calcium levels are often measured to diagnose postoperative hypocalcaemia following thyroidectomy. The aims of this study were to (i) prospectively determine the incidence of symptomatic and biochemical hypocalcaemia following thyroidectomy, (ii) to identify if any associations exist between hypocalcaemia, type of surgery, histological diagnosis, specimen size\\/weight and the presence of histological parathyroid tissue and (iii) to evaluate the necessity of routine measurement of calcium levels following all thyroidectomies.

  16. Differential impairment of semantic and episodic memory in Alzheimer's and Huntington's diseases: a controlled prospective study.

    OpenAIRE

    Hodges, J R; Salmon, D P.; Butters, N

    1990-01-01

    A controlled prospective study compared the performance of 14 patients with dementia of Alzheimer type (DAT) and 14 patients with Huntington's Disease (HD), who were matched for overall level of dementia, on a battery of semantic and episodic memory tests. The DAT patients were significantly more impaired on measures of delayed verbal and figural episodic memory, and in addition showed a more rapid rate of decline on tests which depend upon the integrity of semantic knowledge (naming, number ...

  17. A 5 year prospective study of patient-relevant outcomes after total knee replacement

    DEFF Research Database (Denmark)

    Nilsdotter, A-K; Toksvig-Larsen, S; Roos, E M

    2008-01-01

    OBJECTIVE: To prospectively describe self-reported outcomes up to 5 years after total knee replacement (TKR) in Osteoarthritis (OA) and to study which patient-relevant factors may predict outcomes for pain and physical function (PF). METHODS: 102 consecutive patients with knee OA, 63 women and 39...... postoperatively. RESULTS: Response rate at 5 years was 86%. At 6 months significant improvement was seen in all KOOS and SF-36 scores (P

  18. Intrinsic risk factors for acute ankle injuries among male soccer players : a prospective cohort study

    OpenAIRE

    Engebretsen, Anders Hauge; Myklebust, Grethe; Holme, Ingar Morten K.; Engebretsen, Lars; Bahr, Roald

    2009-01-01

    This prospective cohort study was conducted to identify risk factors for acute ankle injuries among male soccer players. A total of 508 players representing 31 amateur teams were tested during the 2004 pre-season through a questionnaire on previous injury and function score (foot and ankle outcome score; FAOS), functional tests (balance tests on the floor and a balance mat) and a clinical examination of the ankle. Generalized estimating equations were used in univariate analyses to identify c...

  19. A prospective study of nutrition education and oral nutritional supplementation in patients with Alzheimer's disease

    OpenAIRE

    Brant César Q; Okamoto Ivan H.; Novo Neil F.; Juliano Yara; da Silva Rosimeire V; Pivi Glaucia AK; Bertolucci Paulo HF

    2011-01-01

    Abstract Background Weight loss in patients with Alzheimer's disease (AD) is a common clinical manifestation that may have clinical significance. Objectives To evaluate if there is a difference between nutrition education and oral nutritional supplementation on nutritional status in patients with AD. Methods A randomized, prospective 6-month study which enrolled 90 subjects with probable AD aged 65 years or older divided into 3 groups: Control Group (CG) [n = 27], Education Group (EG) [n = 25...

  20. Suction drain tip culture in orthopaedic surgery: a prospective study of 214 clean operations

    OpenAIRE

    Sankar, B.; Ray, P.; Rai, J.

    2004-01-01

    We conducted a prospective cohort study in order to determine whether suction drain specimen cultures from orthopaedic surgery predicted an early wound infection. We included 218 consecutive clean orthopaedic operations requiring drains in one unit over a period of 1 year. The suction drain tip, drain fluid and wound discharge specimens were cultured, and the surgical wound was followed up for 3 months. There were six deep and two superficial wound infections. Wound infection was significantl...

  1. Prospective Clinical Study of 551 Cases of Liposuction and Abdominoplasty Performed Individually and in Combination

    OpenAIRE

    Eric Swanson, MD

    2013-01-01

    Background: Despite the popularity of these procedures, there are limited published prospective studies evaluating liposuction and abdominoplasty. Lipoabdominoplasty is a subject of recent attention. Several investigators have recommended alternative techniques that preserve the Scarpa fascia in an effort to reduce complications, particularly the risk of seromas. Methods: Over a 5-year period, 551 consecutive patients were treated with ultrasonic liposuction alone (n = 384), liposuction/ab...

  2. Risk of Pre-Eclampsia in First and Subsequent Pregnancies: Prospective Cohort Study

    OpenAIRE

    Cnattingius, Sven; Toh, Sengwee; Hernández-Díaz, Sonia

    2009-01-01

    Objective: To investigate whether pre-eclampsia is more common in first pregnancies solely because fewer affected women, who presumably have a higher risk of recurrence, go on to have subsequent pregnancies. Design: Prospective cohort study. Setting: Swedish Medical Birth Register. Participants: 763 795 primiparous mothers who had their first births in Sweden, 1987-2004. Main outcome measures: Pre-eclampsia. Results: The risk of pre-eclampsia was 4.1% in the first pregnancy and 1.7% in later ...

  3. Functional prognosis of dizziness in older adults in primary care: a prospective cohort study.

    OpenAIRE

    Dros, J.; Maarsingh, O.R.; Beem, L.; van der Horst, H.E.; Riet, G. ter; Schellevis, F G; van Weert, H.C.P.M.

    2012-01-01

    Objectives: To investigate the 6-month functional prognosis of dizziness in older adults in primary care, to identify important predictors of dizziness-related impairment, and to construct a score to assist risk prediction. Design: Prospective cohort study with 6-month follow-up. Setting: Twenty-four primary care practices in the Netherlands. Participants: Four hundred seventeen older adults (mean age 78.5, range 65–95, 74% female) presenting consecutively to primary care with dizziness. Meas...

  4. Prospective comparative study of spiral computer tomography and magnetic resonance imaging or detection of hepatocellular carcinoma

    OpenAIRE

    Stoker, J; Romijn, M.G.; Man, de, J.G.; Brouwer, J.T.; Weverling, G.J.; Muiswinkel, van, W.B.; Zondervan, P E; Laméris, J S; Ijzermans, J. N.

    2002-01-01

    textabstractBACKGROUND: Hepatocellular carcinoma (HCC) is often detected at a relatively late stage when tumour size prohibits curative surgery. Screening to detect HCC at an early stage is performed for patients at risk. AIM: The aim of this study was to compare prospectively the diagnostic accuracy and classification for management of the two state of the art secondline imaging techniques: triphasic spiral computer tomography (CT) and super paramagnetic iron oxide (SPIO) enhanced magnetic r...

  5. A prospective study of risk factors for pain persisting 4 months after hysterectomy

    DEFF Research Database (Denmark)

    Brandsborg, Birgitte; Dueholm, Margit; Nikolajsen, Lone;

    2009-01-01

    OBJECTIVES: Chronic pain after hysterectomy is reported by 5% to 32% of women, but it is unknown whether the pain is a result of surgery or can be attributable to other factors such as preoperative and postoperative pain, physical, and psychosocial status. The aim of this prospective study was...... most often related to preoperative factors and acute postoperative pain. The relative contribution of surgery itself is small....

  6. The Interpersonal Antecedents of Supportive Parenting: A Prospective, Longitudinal Study from Infancy to Adulthood

    OpenAIRE

    Raby, K. Lee; Lawler, Jamie M.; Shlafer, Rebecca J.; Hesemeyer, Paloma S.; Collins, W. Andrew; Sroufe, L. Alan

    2014-01-01

    This study drew on prospective, longitudinal data to test the hypothesis that the intergenerational transmission of positive parenting is mediated by competence in subsequent relationships with peers and romantic partners. Interview-based ratings of supportive parenting were completed with a sample of 113 individuals (46% male) followed from birth to age 32. Results indicated that supportive parenting during adulthood was predicted by observed maternal sensitivity during the first three years...

  7. Comparison of Invasive and Noninvasive Mechanical Ventilation for Patients with COPD:Randomised Prospective Study

    OpenAIRE

    Ivo Matic; Visnja Majeric-Kogler; Katarina Sakic-Zdravcevic; Matija Jurjevic; Ivan Mirkovic; Zlatko Hrgovic

    2008-01-01

    Acute respiratory failure due to chronic obstructive pulmonary disease presents an increasing problem for both health and economics in the modern world. The goal of this study was to compare invasive and noninvasive mechani-cal ventilation for patients with COPD. A prospective, randomized trial was performed in a multidisciplinary intensive care unit. Of 614 patients requiring mechanical ventilation (MV) longer than 24h, after excluding those who didn′t meet the inclusion criteria, 72 patient...

  8. Predicting reading and spelling disorders: a 4-year prospective cohort study.

    OpenAIRE

    Bigozzi, Lucia; Tarchi, Christian; Caudek, Corrado; Pinto, Giuliana

    2016-01-01

    In this 4-year prospective cohort study, children with a reading and spelling disorder, children with a spelling impairment, and children without a reading and/or spelling disorder (control group) in a transparent orthography were identified in third grade, and their emergent literacy performances in kindergarten compared retrospectively. Six hundred and forty-two Italian children participated. This cohort was followed from the last year of kindergarten to third grade. In kindergarten, the ch...

  9. Prospective cohort study of predictors of incident low back pain in nurses.

    OpenAIRE

    Smedley, J.; Egger, P.; Cooper, C.; Coggon, D

    1997-01-01

    OBJECTIVE: To assess the impact of handling patients and indicators of individual susceptibility on risk of low back pain in nurses. DESIGN: Prospective cohort study with follow up by repeated self administered every three months over two years. SETTING: NHS university hospital trust. SUBJECTS: 961 female nurses who had been free from low back pain for at least one month at the time of completing a baseline questionnaire. MAIN OUTCOME MEASURES: Incidence of new low back pain during follow up ...

  10. Opportunities and prospects of studying empathy in persons with sexual attraction anomalies

    OpenAIRE

    Demidova L.Yu.; Sheryagina E.V.

    2013-01-01

    The article provides an analysis of the techniques most often used to diagnose empathic ability in sex offenders, and discusses the prospects of using a new projective technique for studying empathy in patients with abnormalities of sexual desire. The analysis showed that the widespread questionnaires have drawbacks that hamper their use in the forensic psychology. A new projective technique for the diagnosis of empathy is proposed, discussing the results of its application on a sample of 47 ...

  11. Inconvenience due to travelers' diarrhea: a prospective follow-up study

    OpenAIRE

    Soonawala Darius; Vlot Jessica A; Visser Leo G

    2011-01-01

    Abstract Background Limited data exist documenting the degree to which travelers are inconvenienced by travelers' diarrhea (TD). We performed a prospective follow-up study at the travel clinic of Leiden University Medical Center in The Netherlands to determine the degree of inconvenience and to determine how experiencing TD affects travelers' perception. Methods Healthy adults who intended to travel to the (sub)tropics for less than two months were invited to take part. Participants filled ou...

  12. A prospective study assessing patient satisfaction at a large tertiary gynecologic oncology/dysplasia unit

    OpenAIRE

    Pather, Selvan

    2010-01-01

    Selvan Pather1, Davina Tai2, Shannon Philp1, Kathryn Nattress1, Jonathan Carter1, Christopher Dalrymple1, Ken Atkinson11The Sydney Gynaecologic Oncology Group, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, Australia; 2Department of Obstetrics and Gynaecology, Royal Prince Alfred Hospital, University of Sydney, Sydney, AustraliaBackground: Patient satisfaction is an important quality assurance measure in the delivery of health care. We conducted a prospective study to assess pati...

  13. Psychosexual outcome after labiaplasty:a prospective case-comparison study

    OpenAIRE

    Veale, David; Naismith, Iona; Eshkevari, Ertiniss; Ellison, Nell; Costa, Ana; Robinson, Dudley; Abeywickrama, Lanka; KAVOUNI, ANGELICA; Cardozo, Linda

    2014-01-01

    Introduction and hypothesisOur goal was to determine psychosexual outcome after labiaplasty in the long-term with specific measures of genital body image and sexual dysfunction.MethodWe conducted a prospective study with a matched-comparison group of women not wanting labiaplasty. Forty-nine women were compared against a group of 39 women matched for age, sexual orientation, ethnicity, and marital status. The labiaplasty group was assessed before, 3 months after and between 11 and 42 months a...

  14. Psychological problems associated with diagnosis and treatment of lymphomas. II: Prospective study.

    OpenAIRE

    Devlen, J; Maguire, P; Phillips, P.(Particle Physics Department, Rutherford Appleton Laboratory, Didcot, United Kingdom); Crowther, D.

    1987-01-01

    A prospective study of 120 patients newly diagnosed as having Hodgkin's disease and non-Hodgkin's lymphoma was conducted to determine the nature, extent, and timing of the psychiatric and social morbidity associated with the diagnosis and treatment. Patients were interviewed at diagnosis and two, six, and 12 months later by trained interviewers using standardised questionnaires. Psychiatric morbidity was greatest in the three months before treatment, but new episodes of anxiety and depression...

  15. Stability of DREEM in a Sample of Medical Students: A Prospective Study

    OpenAIRE

    Muhamad Saiful Bahri Yusoff

    2012-01-01

    Background. Over the last 15 year, DREEM was applied in various educational settings to appraise educational climate. So far, none of article reported its stability in Malaysian medical students. Objective. To determine stability of the DREEM to measure educational climate at different time and occasions using a sample of medical students. Methodology. A prospective cohort study was done on 196 first year medical students. It was administered to the medical students at four different interval...

  16. Early Bactericidal Activity of Moxifloxacin in Treatment of Pulmonary Tuberculosis: a Prospective, Randomized Study

    OpenAIRE

    Pletz, Mathias W. R.; De Roux, Andres; Roth, Andreas; NEUMANN, Karl-Heinz; Mauch, Harald; Lode, Hartmut

    2004-01-01

    Moxifloxacin is the most active fluoroquinolone against Mycobacterium tuberculosis in vitro. However, data about the efficacy in patients are not available. We enrolled 17 patients with tuberculosis in a prospective, randomized study. After 5 days of monotherapy with either moxifloxacin or isoniazid, we detected significant decreases in mean CFU per milliliter in sputum in both groups. The calculated early bactericidal activities for isoniazid and moxifloxacin were 0.209 and 0.273 log10 CFU p...

  17. Predictors of Sexual Hookups: A Theory-Based, Prospective Study of First-Year College Women

    OpenAIRE

    Fielder, Robyn L.; Walsh, Jennifer L.; Carey, Kate B.; Carey, Michael P.

    2013-01-01

    Hooking up, or engaging in sexual interactions outside of committed relationships, has become increasingly common among college students. This study sought to identify predictors of sexual hookup behavior among first-year college women using a prospective longitudinal design. We used problem behavior theory (Jessor, 1991) as an organizing conceptual framework and examined risk and protective factors for hooking up from three domains: personality, behavior, and perceived environment. Participa...

  18. Inflammatory bowel disease in Estonia: a prospective epidemiologic study 1993-1998

    Institute of Scientific and Technical Information of China (English)

    Riina Salupere

    2001-01-01

    @@ INTRODUCTION The incidence of ulcerative colitis (UC) and Crohn,s disease (CD)in Estonia 1993-1998 was investigated prospectively .The mean annual incidence of UC was 1.7 per 100 000,and that of CD1.4 per 100 000.This population-based study showed much lower incidence of UC and CD than those reported for western and northern Europe .

  19. Predictive factors for pregnancy after intrauterine insemination: A prospective study of factors affecting outcome

    OpenAIRE

    Kamath, Mohan S; Priya Bhave; T K Aleyamma; Raju Nair; A Chandy; Mangalaraj, Ann M; Muthukumar, K.; Korula George

    2010-01-01

    Objective : To determine the predictive factors for pregnancy after controlled ovarian hyperstimulation (COH)/intrauterine insemination (IUI). Design : Prospective observational study. Setting : University-level tertiary care center. Patients and Methods : 366 patients undergoing 480 stimulated IUI cycles between November 2007 and December 2008. Interventions : Ovarian stimulation with gonadotrophins was initiated and a single IUI was performed 36 h after triggering ovulation. Main Outcome Me...

  20. Association between dietary patterns and coronary heart disease: a meta-analysis of prospective cohort studies

    OpenAIRE

    Hou, Lina; LI Fei; Wang, Yuanyuan; Ou, Zejin; Xu, Dingli; Tan, Wanlong; Dai, Meng

    2015-01-01

    The associations of dietary patterns with coronary heart disease (CHD) risk remain unclear. Thereby, a meta-analysis was conducted to examine potential relations between dietary patterns and CHD. PubMed and EMBASE databases were searched up to March 2014 for eligible prospective cohort studies regarding the relationships between common dietary patterns and CHD. Random-effects models were applied to calculate the summary relative risk estimates (SRRE) for the highest versus the lowest category...