WorldWideScience

Sample records for 72 hour binge

  1. HUMAN METHAMPHETAMINE PHARMACOKINETICS SIMULATED IN THE RAT: BEHAVIORAL AND NEUROCHEMICAL EFFECTS OF A 72- HOUR BINGE

    Science.gov (United States)

    Kuczenski, Ronald; Segal, David S.; Melega, William P.; Lacan, Goran; McCunney, Stanley J.

    2009-01-01

    Bingeing is one pattern of high dose methamphetamine (METH) abuse which involves continuous drug taking over several days and can result in psychotic behaviors for which the brain pathology remains poorly-defined. A corresponding animal model of this type of METH exposure may provide novel insights into the neurochemical and behavioral sequelae associated with this condition. Accordingly, to simulate the pharmacokinetic profile of a human METH binge exposure in rats we used a computer-controlled, intravenous METH procedure (dynamic infusion) to overcome species differences in METH pharmacokinetics and to replicate the human 12-h plasma METH half-life. Animals were treated over 13 weeks with escalating METH doses, using dynamic infusion, and then exposed to a binge in which drug was administered every 3 h for 72h. Throughout the binge, behavioral effects included unabated intense oral stereotypies in the absence of locomotion and in the absence of sleep. Decrements in regional brain dopamine, norepinephrine and serotonin levels, measured at 1 and 10 h after the last injection of the binge, had, with the exception of caudate-putamen dopamine and frontal cortex serotonin, recovered by 48 h. At 10 h after the last injection of the binge, [3H]ligand binding to dopamine and vesicular monoamine transporters in caudate-putamen were reduced by 35% and 13%, respectively. In a separate METH binge treated cohort, post-binge behavioral alterations were apparent in an attenuated locomotor response to a METH challenge infusion at 24h after the last injection of the binge. Collectively, the changes we characterized during and following a METH binge suggest that for humans under similar exposure conditions, multiple time-dependent neurochemical deficits contribute to their behavioral profiles. PMID:19571794

  2. Human methamphetamine pharmacokinetics simulated in the rat: behavioral and neurochemical effects of a 72-h binge.

    Science.gov (United States)

    Kuczenski, Ronald; Segal, David S; Melega, William P; Lacan, Goran; McCunney, Stanley J

    2009-10-01

    Bingeing is one pattern of high-dose methamphetamine (METH) abuse, which involves continuous drug taking over several days and can result in psychotic behaviors for which the brain pathology remains poorly defined. A corresponding animal model of this type of METH exposure may provide novel insights into the neurochemical and behavioral sequelae associated with this condition. Accordingly, to simulate the pharmacokinetic profile of a human METH binge exposure in rats, we used a computer-controlled, intravenous METH procedure (dynamic infusion, DI) to overcome species differences in METH pharmacokinetics and to replicate the human 12-h plasma METH half-life. Animals were treated over 13 weeks with escalating METH doses, using DI, and then exposed to a binge in which drug was administered every 3 h for 72 h. Throughout the binge, behavioral effects included unabated intense oral stereotypies in the absence of locomotion and in the absence of sleep. Decrements in regional brain dopamine, norepinephrine, and serotonin levels, measured at 1 and 10 h after the last injection of the binge, had, with the exception of caudate-putamen dopamine and frontal cortex serotonin, recovered by 48 h. At 10 h after the last injection of the binge, [(3)H]ligand binding to dopamine and vesicular monoamine transporters in caudate-putamen were reduced by 35 and 13%, respectively. In a separate METH binge-treated cohort, post-binge behavioral alterations were apparent in an attenuated locomotor response to a METH challenge infusion at 24 h after the last injection of the binge. Collectively, the changes we characterized during and after a METH binge suggest that for human beings under similar exposure conditions, multiple time-dependent neurochemical deficits contribute to their behavioral profiles.

  3. Analysis of 72-hour sterility of common pediatric continuous intravenous infusions.

    Science.gov (United States)

    Piro, Christina C; Davis, Jennifer; Frelix, Arlesia; Grisso, Alison G; Sinclair-Pingel, Julie; Willingham, Harold; Wright, Lorianne; Potts, Amy L

    2009-01-01

    Patient morbidity and mortality associated with contaminated and improperly prepared sterile products has captured national attention. In response, both the United States Pharmacopeia (USP) and Centers for Disease Control (CDC) have published recommendations in an effort to minimize the risk of infection. While the CDC recommends that administration sets are not changed more frequently than every 72 hours, the USP recommends a maximum beyond use date of 48 hours. Neither organization provides specific guidance on expiration dating once the intravenous drug is dispensed. Likewise, neither addresses the length of time that a bag containing medication for continuous infusion may hang once administration to the patient has begun. We evaluated the sterility of medications that are commonly administered by continuous infusion to pediatric patients. Because frequent manipulation of infusion and administration sets may predispose the patient to adverse events, we evaluated sterility for extended beyond use dating up to 72 hours. Thirty-five common intravenous (IV) continuous infusions using 94 standard concentrations and diluents were identified. IV solutions were mixed using sterile technique in the laminar flow hood in accordance with USP guidelines. Medications were excluded for short stability, short durations of use or high cost. A sample from each solution was tested for contamination or bacterial growth at 72 hours. Any visible discoloration suggesting physical instability was also evaluated. None of the syringes or chambers resulted in contamination, bacterial growth or discoloration after 72 hours. This study provides sufficient data that these compounded sterile products may be stored using a beyond use date up to 72 hours for a number of commonly used continuous IV infusions in pediatric patients. In our institution, this allows for a more convenient and consistent change of both administration sets and continuous infusions at 72 hours to potentially minimize

  4. Change in the body temperature of healthy term infant over the first 72 hours of life

    Institute of Scientific and Technical Information of China (English)

    李萌霞; 孙革; NEUBAUERHenning

    2004-01-01

    Objective:To determine the range of body temperature in a group of healthy Chinese term neonates over the first 72 hours of life and to assess the influence of body weight, gestational age and route of delivery.Method: All 200 consecutive cases of neonates delivered at our hospital from March to August 2001 were included in this retrospective study.Temperatures were measured immediately after delivery, after 30 minutes, 1 hour, 2 hours, 8 hours and 15 hours and on the 2nd and 3rd day. Axillary temperatures ranging from 36.5℃ to 37℃ were regarded as normal. No cases of maternal fever or systemic infection of the newborns were discovered. All infants were discharged in good general condition. Results:The mean rectal temperature at birth was 37.19℃. The lowest average temperature was reached at 1 hour after delivery (36.54℃) with a significant difference between natural delivery (36.48℃) and section (36.59℃) (P<0.05).Temperature subsequently rose to 36.70℃ at 8 hours and 36.78℃ at 15 hours (P<0.05).Hypothermia was seen in 51.8% and hypothermia in 42.5% of the patients.On the 3rd day after delivery, 96% of all temperatures were in the normal range. A significant relation was found between hypothermia and both low birth weight (P<0.001) and low gestational age (P<0.05).Conclusion: The reference range presently used did not include all physiological temperatures in the first 72 hours of life. Considering other factors,such as birth weight, route of delivery,gestational age and body temperature on the 2nd and 3rd day of life, may help to correctly assess the significance of temperatures beyond the reference range.

  5. Change in the body temperature of healthy term infant over the first 72 hours of life

    Institute of Scientific and Technical Information of China (English)

    LI Meng-xia (李萌霞); SUN Ge (孙革); NEUBAUER Henning

    2004-01-01

    Objective: To determine the range of body temperature in a group of healthy Chinese term neonates over the first 72 hours of life and to assess the influence of body weight, gestational age and route of delivery. Method: All 200 consecutive cases of neonates delivered at our hospital from March to August 2001 were included in this retrospective study. Temperatures were measured immediately after delivery, after 30 minutes, 1 hour, 2 hours, 8 hours and 15 hours and on the 2nd and 3rd day. Axillary temperatures ranging from 36.5 oC to 37 oC were regarded as normal. No cases of maternal fever or systemic infection of the newborns were discovered. All infants were discharged in good general condition. Results: The mean rectal temperature at birth was 37.19 ℃. The lowest average temperature was reached at 1 hour after delivery (36.54 ℃) with a significant difference between natural delivery (36.48 ℃) and section (36.59 ℃) (P<0.05). Temperature subsequently rose to 36.70 ℃ at 8 hours and 36.78 ℃ at 15 hours (P<0.05). Hypothermia was seen in 51.8% and hypothermia in 42.5% of the patients. On the 3rd day after delivery, 96% of all temperatures were in the normal range. A significant relation was found between hypothermia and both low birth weight (P<0.001) and low gestational age (P<0.05). Conclusion: The reference range presently used did not include all physiological temperatures in the first 72 hours of life. Considering other factors, such as birth weight, route of delivery, gestational age and body temperature on the 2nd and 3rd day of life, may help to correctly assess the significance of temperatures beyond the reference range.

  6. Prediction of outcome in neurogenic oropharyngeal dysphagia within 72 hours of acute stroke.

    Science.gov (United States)

    Ickenstein, Guntram W; Höhlig, Carolin; Prosiegel, Mario; Koch, Horst; Dziewas, Rainer; Bodechtel, Ulf; Müller, Rainer; Reichmann, Heinz; Riecker, Axel

    2012-10-01

    Stroke is the most frequent cause of neurogenic oropharyngeal dysphagia (NOD). In the acute phase of stroke, the frequency of NOD is greater than 50% and, half of this patient population return to good swallowing within 14 days while the other half develop chronic dysphagia. Because dysphagia leads to aspiration pneumonia, malnutrition, and in-hospital mortality, it is important to pay attention to swallowing problems. The question arises if a prediction of severe chronic dysphagia is possible within the first 72 hours of acute stroke. On admission to the stroke unit, all stroke patients were screened for swallowing problems by the nursing staff within 2 hours. Patients showing signs of aspiration were included in the study (n = 114) and were given a clinical swallowing examination (CSE) by the swallowing/speech therapist within 24 hours and a swallowing endoscopy within 72 hours by the physician. The primary outcome of the study was the functional communication measure (FCM) of swallowing (score 1-3, tube feeding dependency) on day 90. The grading system with the FCM swallowing and the penetration-aspiration scale (PAS) in the first 72 hours was tested in a multivariate analysis for its predictive value for tube feeding-dependency on day 90. For the FCM level 1 to 3 (P dysphagia scales to prevent aspiration pneumonia and malnutrition. A dysphagia program can lead to better communication within the stroke unit team to initiate the appropriate diagnostics and swallowing therapy as soon as possible. Copyright © 2012 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  7. Operational Solar Forecasting System for DNI and GHI for Horizons Covering 5 Minutes to 72 Hours

    Science.gov (United States)

    Coimbra, C. F.

    2014-12-01

    I will describe the methodology used to develop and deploy operationally a comprehensive solar forecasting system for both concentrated and non-concentrated solar technologies. This operational forecasting system ingests data from local telemetry, remote sensing and Numerical Weather Prediction (NWP) models, processes all the diferent types of data (time series, sky images, satellite images, gridded data, etc.) to produce concatenated solar forecasts from 5 minutes out to 72 hours into the future. Each forecast is optimized with stochastic learning techniques that include input selection, model topology optimization, model output statistics, metric fitness optimization and machine learning. These forecasts are used by solar generators (plant managers), utilities and independent system operators for operations, scheduling, dispatching and market participation.

  8. DNA degradation within mouse brain and dental pulp cells 72 hours postmortem

    Institute of Scientific and Technical Information of China (English)

    Jilong Zheng; Xiaona Li; Di Shan; Han Zhang; Dawei Guan

    2012-01-01

    In this study, we sought to elucidate the process of DNA degradation in brain and dental pulp cells of mice, within postmortem 0-72 hours, by using the single cell gel electrophoresis assay and professional comet image analysis and processing techniques. The frequency of comet-like cells, the percentage of tail DNA, tail length, tail moment, Olive moment and tail area increased in tandem with increasing postmortem interval. In contrast, the head radius, the percentage of head DNA and head area showed a decreasing trend. Linear regression analysis revealed a high correlation between these parameters and the postmortem interval. The findings suggest that the single cell gel electrophoresis assay is a quick and sensitive method to detect DNA degradation in brain and dental pulp cells, providing an objective and accurate new way to estimate postmortem interval.

  9. Same admission laparoscopic cholecystectomy for acute cholecystitis: is the "golden 72 hours" rule still relevant?

    Science.gov (United States)

    Tan, Jarrod K H; Goh, Joel C I; Lim, Janice W L; Shridhar, Iyer G; Madhavan, Krishnakumar; Kow, Alfred W C

    2017-01-01

    Studies have shown that same admission laparoscopic cholecystectomy (SALC) is superior to delayed laparoscopic cholecystectomy for acute cholecystitis (AC). While some proposed a"golden 72-hour" for SALC, the optimal timing remains controversial. The aim of the study was to compare the outcomes of SALC in AC patients with different time intervals from symptom onset. A retrospective analysis of 311 patients who underwent SALC for AC from June 2010-June 2015 was performed. Patients were divided into three groups based on the time interval between symptom onset and surgery: 7 (L-SALC). The mean duration of symptoms was 2(1-3), 5(4-7) and 9 (8-13) days for E-SALC, M-SALC and L-SALC, respectively (p < 0.001). Conversion rates were higher in the L-SALC group [E-SALC, 8.2% vs M-SALC, 9.6% vs L-SALC, 21.4%] (p = 0.048). The total length of stay was longer in patients with longer symptom duration [E-SALC, 4 (2-33) vs M-SALC, 2 (2-23) vs L-SALC, 7 (2-49)] (p < 0.001). Patients with AC presenting beyond 7 days of symptoms have higher conversion rates and longer length of stay associated with SALC. However, patients with less than a week of symptoms should be offered SALC. Copyright © 2016 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.

  10. Examining Duration of Binge Eating Episodes in Binge Eating Disorder

    Science.gov (United States)

    Schreiber-Gregory, Deanna N.; Lavender, Jason M.; Engel, Scott G.; Wonderlich, Steve A.; Crosby, Ross D.; Peterson, Carol B.; Simonich, Heather; Crow, Scott; Durkin, Nora; Mitchell, James E.

    2013-01-01

    Objective The primary goal of this paper is to examine and clarify characteristics of binge eating in individuals with binge eating disorder (BED), particularly the duration of binge eating episodes, as well as potential differences between individuals with shorter compared to longer binge eating episodes. Method Two studies exploring binge eating characteristics in BED were conducted. Study 1 examined differences in clinical variables among individuals (N = 139) with BED who reported a short (binge duration. Study 2 utilized an ecological momentary assessment (EMA) design to examine the duration and temporal pattern of binge eating episodes in the natural environment in a separate sample of nine women with BED. Results Participants in Study 1 who were classified as having long duration binge eating episodes displayed greater symptoms of depression and lower self-esteem, but did not differ on other measures of eating disorder symptoms, compared to those with short duration binge eating episodes. In Study 2, the average binge episode duration was approximately 42 minutes, and binge eating episodes were most common during the early afternoon and evening hours, as well as more common on weekdays versus weekends. Discussion Past research on binge episode characteristics, particularly duration, has been limited to studies of binge eating episodes in BN. This study contributes to the existing literature on characteristics of binge eating in BED. PMID:23881639

  11. Binge Drinking

    Medline Plus

    Full Text Available ... Chronic Disease Prevention and Health Promotion (NCCDPHP) Injury, Violence & Safety Featured Videos Binge Drinking Binge Drinking A ... Safe Teen Drivers Break the Silence: Stop the Violence Break the Silence: Stop the Violence Binge Drinking ...

  12. Binge Drinking

    Medline Plus

    Full Text Available ... children, parents, and public health professionals. More > Binge Drinking (4:23) Recommend on Facebook Tweet Share Compartir Binge Drinking Binge Drinking Transcript [23 KB, 2 pages] High resolution [27. ...

  13. Exercise attenuates negative effects of abstinence during 72 hours of smoking deprivation.

    Science.gov (United States)

    Conklin, Cynthia A; Soreca, Isabella; Kupfer, David J; Cheng, Yu; Salkeld, Ronald P; Mumma, Joel M; Jakicic, John M; Joyce, Christopher J

    2017-08-01

    Exercise is presumed to be a potentially helpful smoking cessation adjunct reputed to attenuate the negative effects of deprivation. The present study examined the effectiveness of moderate within-session exercise to reduce 4 key symptoms of smoking deprivation during 3 72-hr nicotine abstinence blocks in both male and female smokers. Forty-nine (25 male, 24 female) sedentary smokers abstained from smoking for 3 consecutive days on 3 separate occasions. At each session, smokers' abstinence-induced craving, cue-induced craving, negative mood, and withdrawal symptom severity were assessed prior to and after either exercise (a.m. exercise, p.m. exercise) or a sedentary control activity (magazine reading). Abstinence-induced craving and negative mood differed as a function of condition, F(2, 385) = 21, p effect size Cohen's d = 0.64; and negative mood, t(385) = 2.25, p = .03, d = 0.23. Overall exercise also led to a larger pre-post reduction in cue-induced craving in response to smoking cues, F(2, 387) = 8.94, p = .0002; and withdrawal severity, F(2, 385) = 3.8, p = .02. Unlike the other 3 measures, p.m. exercise reduced withdrawal severity over control, t(385) = 2.64, p = .009, d = 0.27, whereas a.m. exercise did not. The results support the clinical potential of exercise to assist smokers in managing common and robust negative symptoms experienced during the first 3 days of abstinence. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  14. Predicting Factors and Risk Stratification for Return Visits to the Emergency Department Within 72 Hours in Pediatric Patients.

    Science.gov (United States)

    Sung, Sheng-Feng; Liu, Kang Ernest; Chen, Solomon Chih-Cheng; Lo, Chia-Lun; Lin, Kuei-Chih; Hu, Ya-Han

    2015-12-01

    A return visit (RV) to the emergency department (ED) is usually used as a quality indicator for EDs. A thorough comprehension of factors affecting RVs is beneficial to enhancing the quality of emergency care. We performed this study to identify pediatric patients at high risk of RVs using readily available characteristics during an ED visit. We retrospectively collected data of pediatric patients visiting 6 branches of an urban hospital during 2007. Potential variables were analyzed using a multivariable logistic regression analysis to determine factors associated with RVs and a classification and regression tree technique to identify high-risk groups. Of the 35,435 visits from which patients were discharged home, 2291 (6.47%) visits incurred an RV within 72 hours. On multivariable analysis, younger age, weekday visits, diagnoses belonging to the category of symptoms, signs, and ill-defined conditions, and being seen by a female physician were associated with a higher probability of RVs. Children younger than 6.5 years who visited on weekdays or between midnight and 8:00 AM on weekends or holidays had the highest probability of returning to the ED within 72 hours. Our study reexamined several important factors that could affect RVs of pediatric patients to the ED and identified high-risk groups of RVs. Further intervention studies or qualitative research could be targeted on these at-risk groups.

  15. Hypoglycemia Secondary to Sulfonylurea Ingestion in a Patient with End Stage Renal Disease: Results from a 72-Hour Fast

    Directory of Open Access Journals (Sweden)

    Alice Abraham

    2015-01-01

    Full Text Available Insulin, proinsulin, and C-peptide levels increase with sulfonylurea exposure but the acuity of increase has not been described in dialysis patients. We present a case of a dialysis patient who presented with hypoglycemia and was found to have accidental sulfonylurea ingestion. This is a 73-year-old man with ESRD on peritoneal dialysis, without history of diabetes, who presented with hypoglycemia. Past medical history includes multiple myeloma, congestive heart failure, and hypertension. At initial presentation, his blood glucose was 47 mg/dL, with concomitant elevations in the following: C-peptide 30.5 (nl: 0.8–3.5 ng/mL, insulin 76 (nl: 3–19 μIU/mL, and proinsulin 83.3 (nl: ≤8.0 pmol/L. During the 72-hour fast, which he completed without hypoglycemia, insulin declined to be within normal limits (to 12 μIU/mL; proinsulin (to 12.1 pmol/L and C-peptide (to 7.2 ng/mL levels decreased but remained elevated. The sulfonylurea screen ultimately returned positive for glipizide, clinching the diagnosis. This is the first reported case which characterizes the chronic elevation of proinsulin in a patient with ESRD, as well as its dramatic increase after a presumed solitary exposure to sulfonylurea. The 72-hour fast conducted gives insight into the clearance of insulin, proinsulin, and C-peptide after sulfonylurea ingestion in ESRD.

  16. Repeated Intra-Arterial Thrombectomy within 72 Hours in a Patient with a Clear Contraindication for Intravenous Thrombolysis

    Directory of Open Access Journals (Sweden)

    Mona Laible

    2015-01-01

    Full Text Available Introduction. Treating patients with acute ischemic stroke, proximal arterial vessel occlusion, and absolute contraindication for administering intravenous recombinant tissue plasminogen activator (rtPA poses a therapeutic challenge. Intra-arterial thrombectomy constitutes an alternative treatment option. Materials and Methods. We report a case of a 57-year-old patient with concomitant gastric adenocarcinoma, who received three intra-arterial thrombectomies in 72 hours due to repeated occlusion of the left medial cerebral artery (MCA. Findings. Intra-arterial recanalization of the left medial cerebral artery was performed three times with initially good success. However, two days later, the right medial cerebral artery became occluded. Owing to the overall poor prognosis at that time and knowing the wishes of the patient, we decided not to perform another intra-arterial recanalization procedure. Conclusion. To our knowledge, this is the first case illustrating the use of repeated intra-arterial recanalization in early reocclusion of intracranial vessels.

  17. Binge Drinking

    Medline Plus

    Full Text Available ... Chronic Disease Prevention and Health Promotion (NCCDPHP) Injury, Violence & Safety Featured Videos Binge Drinking A Time To ... Safe Teen Drivers Break the Silence: Stop the Violence More Information Vital Signs Binge Drinking Information Alcohol & ...

  18. Binge Drinking

    Medline Plus

    Full Text Available ... A Time To Act Binge Drinking Break the Silence: Stop the Violence Injury Prevention Research In the ... Swim of Things Safe Teen Drivers Break the Silence: Stop the Violence More Information Vital Signs Binge ...

  19. Binge Drinking

    Medline Plus

    Full Text Available ... discusses effective community prevention strategies such as increasing alcohol excise taxes. The video also features experts who ... Violence More Information Vital Signs Binge Drinking Information Alcohol & Public Health Binge Drinking Factsheet Effective Prevention Strategies ...

  20. Binge Drinking

    Medline Plus

    Full Text Available ... for Chronic Disease Prevention and Health Promotion (NCCDPHP) Injury, Violence & Safety Featured Videos Binge Drinking Binge Drinking A Time To Act A Time To Act Injury Prevention Research Injury Prevention Research In the Swim ...

  1. Improved detection of silent atrial fibrillation using 72-hour Holter ECG in patients with ischemic stroke: a prospective multicenter cohort study.

    Science.gov (United States)

    Grond, Martin; Jauss, Marek; Hamann, Gerhard; Stark, Erwin; Veltkamp, Roland; Nabavi, Darius; Horn, Markus; Weimar, Christian; Köhrmann, Martin; Wachter, Rolf; Rosin, Ludger; Kirchhof, Paulus

    2013-12-01

    Adequate diagnosis of atrial fibrillation (AF), including paroxysmal AF, is an important part of stroke workup. Prolonged ECG monitoring may improve the detection of paroxysmal, previously undiagnosed AF (unknown AF). Therefore, we evaluated systematic 72-hour Holter ECG monitoring to detect unknown AF for the workup of patients with stroke. Unselected survivors of a stroke or transient ischemic attack (TIA) without known AF were enrolled in a prospective, multicenter cohort study of 72-hour Holter ECG monitoring in 9 German secondary and tertiary stroke centers between May 2010 and January 2011. In addition to standardized workup of stroke pathogenesis according to the German Stroke Unit protocol, all patients underwent 72-hour Holter ECG monitoring directly after admission. All ECGs were centrally analyzed by 2 independent observers. We determined the proportion of unknown AF and compared the detection rates of 72- and 24-hour monitoring. A total of 1135 patients were enrolled (mean age, 67 years [SD, 13.1 years], 45% women, 29% TIA). Unknown AF was detected in 49 out of 1135 patients (4.3%, [95% confidence interval, 3.4-5.2%]) by 72-hour ECG monitoring. Unknown AF was diagnosed in 29 patients (2.6%) within the first 24 hours of ECG monitoring, and in 20 more patients only by 72 hours of ECG monitoring. The number needed to screen by 72-hour ECG was 55 patients (95% confidence interval [35-123]) for each additional AF diagnosis. Patients with unknown AF were significantly older and had more often a history of previous stroke. Patients with unknown AF were equally distributed within categories of pathogenesis according to Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification. In unselected survivors of stroke or TIA, 72-hour ECG monitoring is feasible and improves the detection rate of silent paroxysmal AF.

  2. Optimal concentration and time window for proliferation and differentiation of neural stem cells from embryonic cerebral cortex:5% oxygen preconditioning for 72 hours

    Institute of Scientific and Technical Information of China (English)

    Li-li Yuan; Ying-jun Guan; Deng-dian Ma; Hong-mei Du

    2015-01-01

    Hypoxia promotes proliferation and differentiation of neural stem cells from embryonic day 12 rat brain tissue, but the concentration and time of hypoxic preconditioning are controversial. To address this, we cultured neural stem cells isolated from embryonic day 14 rat cerebral cortex in 5% and 10% oxygenin vitro. MTT assay, neurosphere number, and immunolfuorescent staining found that 5% or 10% oxygen preconditioning for 72 hours improved neural stem cell viability and proliferation. With prolonged hypoxic duration (120 hours), the proportion of apoptotic cells increased. Thus, 5% oxygen preconditioning for 72 hours promotes neural stem cell prolif-eration and neuronal differentiation. Our ifndings indicate that the optimal concentration and duration of hypoxic preconditioning for promoting proliferation and differentiation of neural stem cells from the cerebral cortex are 5% oxygen for 72 hours.

  3. Examination of why some community pharmacists do not provide 72-hour emergency prescription drugs to Medicaid patients when prior authorization is not available.

    Science.gov (United States)

    Shepherd, Marvin D

    2013-09-01

    Existing federal law requires that a 72-hour emergency supply of a prescription drug be dispensed to Medicaid patients when prior authorization (PA) is not available and the medication is needed without delay. The pharmacist's role is to contact prescribers and inform them that PA is needed. If the prescriber cannot be reached, the pharmacist can dispense a 72-hour emergency supply. To determine (a) the reasons why some community pharmacy owners/managers, staff pharmacists, and technicians are not compliant with the law; (b) how often the decision is made; and (c) estimate how often pharmacies do not dispense the 72-hour emergency supply when PA is not available. A questionnaire was mailed to selected Texas community pharmacies. The instrument was developed by the researcher and reviewed by the Texas Medicaid Vendor Drug Program staff. The University of Texas, Office of Survey Research collected the data in September and October of 2011 by mail and online. The data were forwarded to the researcher for analyses. A total of 788 identified community pharmacies were mailed a packet containing 3 questionnaires to be completed by the pharmacist-in-charge, a staff pharmacist, and a pharmacy technician. There were 2 mailings of the questionnaire packet and follow-up telephone calls to nonrespondents. A total of 653 questionnaires were completed and returned from 288 community pharmacies (36.7%) out of 788 pharmacies that were mailed the questionnaire packets. A total of 368 (57.5%) completed questionnaires came from chain store pharmacy respondents and 272 (42.5%) questionnaires from independent pharmacy respondents. A total of 21.3% (n = 134) of the respondents indicated that they were not aware of the federal and state requirement to dispense a 72-hour emergency supply of a prescription drug to Medicaid patients when prior authorization (PA) is not available. A greater proportion of the chain store respondents (26.6%) were unaware of the requirement compared with the

  4. Dynamic Changes of Pulmonary Arterial Pressure and Ductus Arteriosus in Human Newborns From Birth to 72 Hours of Age

    OpenAIRE

    2016-01-01

    Abstract Normal pulmonary artery pressure and pulmonary hypertension assessment of newborns is rarely reported. The aim of the study is to explore dynamic changes of pulmonary arterial pressure and ductus arteriosus in human newborns from birth to 72 h of age with echocardiography. A total of 76 cases of normal newborns were prospectively detected by echocardiography after birth of 2 h, 6 h, 12 h, 24 h, 48 h, and 72 h, respectively. Ductus arteriosus diameter, blood shunt direction, blood flo...

  5. Binge Drinking

    Medline Plus

    Full Text Available ... problem among youth. Release Date: 4/13/2010 Source: National Center for Chronic Disease Prevention and Health Promotion ... More Information Vital Signs Binge Drinking Information Alcohol & Public Health ...

  6. Binge Drinking

    Medline Plus

    Full Text Available ... Drivers Life Stages & Populations A Killer in Indian Country Baby Steps: Learn the Signs. Act Early. Dangerous ... allowfullscreen> The video explores the health risks of binge drinking – including unintended pregnancy, sexually transmitted ...

  7. Binge Drinking

    Medline Plus

    Full Text Available ... the health risks of binge drinking – including unintended pregnancy, sexually transmitted diseases, injury, car crashes, violence and HIV/AIDS – and discusses effective community prevention strategies such ...

  8. Binge Drinking

    Medline Plus

    Full Text Available ... car crashes, violence and HIV/AIDS – and discusses effective community prevention strategies such as increasing alcohol excise ... Drinking Information Alcohol & Public Health Binge Drinking Factsheet Effective Prevention Strategies Send Us Feedback What do you ...

  9. Binge Drinking

    Medline Plus

    Full Text Available ... 27.9 MB] Open Captioned [12.6 MB] Request a higher resolution file Copy the code below ... Drivers Break the Silence: Stop the Violence More Information Vital Signs Binge Drinking Information Alcohol & Public Health ...

  10. Binge Drinking

    Medline Plus

    Full Text Available ... captioning. Videos are prepared for different audiences including, children, parents, and public health professionals. More > Binge Drinking ( ... captioning. Videos are prepared for different audiences including, children, parents, and public health professionals. More > File Formats ...

  11. Binge Drinking

    Medline Plus

    Full Text Available ... Improve Systemic Analysis (10:45) Take 3 Teen Pregnancy The Immunization Baby Book The Story of Folic ... the health risks of binge drinking - including unintended pregnancy, sexually transmitted diseases, injury, car crashes, violence and ...

  12. Binge Drinking

    Medline Plus

    Full Text Available ... Way to Go Way to Go: Many Healthy Returns (4:00) Way to Go: Passport To Health ( ... allowfullscreen> The video explores the health risks of binge drinking – including unintended pregnancy, sexually transmitted ...

  13. Binge Drinking

    Medline Plus

    Full Text Available ... Break the Silence: Stop the Violence Injury Prevention Research In the Swim of Things Safe Teen Drivers ... Binge Drinking A Time To Act Injury Prevention Research In the Swim of Things Safe Teen Drivers ...

  14. Binge Drinking

    Medline Plus

    Full Text Available ... for Chronic Disease Prevention and Health Promotion (NCCDPHP) Injury, Violence & Safety Featured Videos Binge Drinking A Time To Act Injury Prevention Research In the Swim of Things Safe ...

  15. Binge Drinking

    Medline Plus

    Full Text Available ... To Health (4:17) Vital Signs High Blood Pressure Spanish Diseases & Conditions Hablemos de la Influenza Influenza ... Videos are prepared for different audiences including, children, parents, and public health professionals. More > Binge Drinking (4: ...

  16. Binge Drinking

    Medline Plus

    Full Text Available ... and HIV/AIDS – and discusses effective community prevention strategies such as increasing alcohol excise taxes. The video ... Alcohol & Public Health Binge Drinking Factsheet Effective Prevention Strategies Send Us Feedback What do you think of ...

  17. Binge Drinking

    Medline Plus

    Full Text Available ... Please Parents Want To Do What′s Best The Obesity Epidemic Outbreaks CDC: Protecting Americans through Global Health ... captioning. Videos are prepared for different audiences including, children, parents, and public health professionals. More > Binge Drinking ( ...

  18. Binge Drinking

    Medline Plus

    Full Text Available ... and HIV/AIDS - and discusses effective community prevention strategies such as increasing alcohol excise taxes. The video ... Alcohol & Public Health Binge Drinking Factsheet Effective Prevention Strategies Send Us Feedback What do you think of ...

  19. Binge Drinking

    Medline Plus

    Full Text Available ... Passport To Health (4:17) Vital Signs High Blood Pressure Spanish ... video explores the health risks of binge drinking – including unintended pregnancy, sexually transmitted ...

  20. Binge Drinking

    Medline Plus

    Full Text Available ... Streep (:30) Version B Your Wake-Up Call Common Conditions A Change for Life Arthritis Pain Reliever ... taxes. The video also features experts who debunk common myths including the belief that binge drinking is ...

  1. GABA-BZD Receptor Modulating Mechanism of Panax quinquefolius against 72-hours Sleep Deprivation Induced Anxiety like Behavior: Possible Roles of Oxidative Stress, Mitochondrial Dysfunction and Neuroinflammation

    Directory of Open Access Journals (Sweden)

    Priyanka eChanana

    2016-03-01

    Full Text Available ABSTRACTRationale- Panax quinquefolius (American Ginseng is known for its therapeutic potential against various neurological disorders, but its plausible mechanism of action still remains undeciphered. GABA (Gamma Amino Butyric Acid plays an important role in sleep wake cycle homeostasis. Thus there exists rationale in exploring the GABA-ergic potential of Panax quinquefolius as neuroprotective strategy in sleep deprivation induced secondary neurological problems.Objective- The present study was designed to explore the possible GABA-ergic mechanism in the neuro-protective effect of Panax quinquefolius against 72-hours sleep deprivation induced anxiety like behaviour, oxidative stress, mitochondrial dysfunction, HPA-axis activation and neuroinflammation.Materials and Methods- Male laca mice were sleep deprived for 72-hours by using Grid suspended over water method. Panax quinquefolius (American Ginseng 50, 100 and 200 mg/kg was administered alone and in combination with GABA modulators (GABA Cl- channel inhibitor, GABA-benzodiazepine receptor inhibitor and GABAA agonist for 8 days, starting five days prior to 72-hours sleep deprivation period. Various behavioural (locomotor activity, mirror chamber test, biochemical (lipid peroxidation, reduced glutathione, catalase, nitrite levels, mitochondrial complexes, neuroinflammation marker (Tumour Necrosis Factor, TNF-alpha, serum corticosterone, and histopathological sections of brains were assessed. Results- 72-hours sleep deprivation significantly impaired locomotor activity, caused anxiety-like behaviour, conditions of oxidative stress, alterations in mitochondrial enzyme complex activities, raised serum corticosterone levels, brain TNFα levels and led to neuroinflammation like signs in discrete brain areas as compared to naive group. Panax quinquefolius (100 and 200 mg/kg treatment restored the behavioural, biochemical, mitochondrial, molecular and histopathological alterations. Pre-treatment of

  2. Binge Drinking

    Medline Plus

    Full Text Available ... to Improve Systemic Analysis (10:45) Take 3 Teen Pregnancy The Immunization Baby Book The Story of Folic ... the health risks of binge drinking - including unintended pregnancy, sexually transmitted diseases, injury, car ... Teen Drivers Safe Teen Drivers Break the Silence: Stop ...

  3. Binge Drinking

    Medline Plus

    Full Text Available ... Go: Passport To Health (4:17) Vital Signs High Blood Pressure Spanish Diseases & Conditions Hablemos de la Influenza Influenza ... allowfullscreen> The video explores the health risks of binge drinking – including unintended pregnancy, sexually transmitted ...

  4. Binge Drinking

    Centers for Disease Control (CDC) Podcasts

    2010-04-13

    This podcast explores the health risks of binge drinking and discusses effective community strategies to prevent it.  Created: 4/13/2010 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 4/13/2010.

  5. Binge Drinking

    Medline Plus

    Full Text Available ... this video: