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Sample records for 52-week treatment period

  1. Long-Term Treatment Outcome in Adult Male Prisoners With Attention-Deficit/Hyperactivity Disorder: Three-Year Naturalistic Follow-Up of a 52-Week Methylphenidate Trial.

    Science.gov (United States)

    Ginsberg, Ylva; Långström, Niklas; Larsson, Henrik; Lindefors, Nils

    2015-10-01

    Despite high rates of attention-deficit/hyperactivity disorder (ADHD) among adult lawbreakers, particularly the long-term effects of ADHD pharmacotherapy remain unclear, not the least because of ethical challenges with preventing control subjects in randomized controlled trials from receiving medication over prolonged time. We followed up adult male prisoners with ADHD who completed a 5-week randomized, double-blind, placebo-controlled trial followed by a 47-week open-label extension of osmotic-release oral system methylphenidate in a Swedish high-security prison from 2007 to 2010 (ClinicalTrials.gov: NCT00482313). Twenty-five trial completers were prospectively followed up clinically 1 year (24/25, 96% participated fully or in part) and 3 years (20/25, 80% participation) after trial regarding ADHD symptoms (observer and self-reports), psychosocial functioning, substance misuse, and criminal reoffending. Methylphenidate-related improvements in ADHD symptoms and psychosocial functioning obtained during the 52-week trial were maintained at 1- and 3-year follow-ups. Specifically, after 3 years, 75% (15/20) of the respondents had been released from prison, and 67% of these (10/15) had employment, usually full time. In contrast, nonmedicated respondents at the 3-year follow-up (5/20) reported more ADHD symptoms, functional impairment, and substance misuse compared with currently medicated respondents (15/20). Further, 40% of the respondents self-reported reoffending, indicating a substantially lower relapse rate than expected (70%-80%).In summary, although these observations need validation from new and larger samples, positive effects were maintained after 4 years of methylphenidate treatment. Most study completers were employed and had no relapse in substance misuse or criminality. These results suggest that motivational support and continued medication are important for improved outcome in adult criminal offenders with ADHD. PMID:26284932

  2. Efficacy and safety of treatment with human insulin analogues in daily management of insulin naive patients with type 2 diabetes mellitus: results of multicenter 52-week observational study A1chive

    Directory of Open Access Journals (Sweden)

    Marina Vladimirovna Shestakova

    2012-12-01

    Full Text Available Modern insulin analogues allow safe improvement of glycemic control (not accompanied with increase in body mass or rate of severe hypoglycemic events and its efficient maintenance during long period of time. In this paper we present results of multicenter 52-week prospective observational study A1chive (Russian cohort, n=9342, designed to assess safety and efficacy of treatment with human insulin analogues (Levemir®, NovoMix® 30 and NovoRapid® (Novo Nordisk in daily management of insulin naive patients with type 2 diabetes mellitus. Prescription of human insulin analogues resulted in clinically and statistically significant improvement of glycemic control irrespective of initial insulin regimen. Therapy by various regimens (Levemir®, NovoMix® 30 or Levemir® + NovoRapid® under conditions of daily clinical practice leads to marked improvement in glycemic control as measured by HbA1c (-2.9% in 12 month with no evidence for negative influence on tolerability and short-term safety of the treatment. Furthermore, decrease in HbA1c levels was associated with pronounced and stable decrease in fasting and postprandial glucose levels (-5.0 mmol/L and -5.7 mmol/L, respectively. By the end of the follow-up all regimen groups reported improvement of QoL by treatment satisfaction criterion.

  3. Comparison of Different Treatment Modalities for Type 1 Diabetes, Including Sensor-Augmented Insulin Regimens, in 52 Weeks of Follow-Up: A COMISAIR Study

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    Petruželková, Lenka; Flekač, Milan; Pelcl, Tomáš; Matoulek, Martin; Daňková, Martina; Škrha, Jan; Svačina, Štěpán; Prázný, Martin

    2016-01-01

    Abstract Objective: To compare different treatment modalities for patients with type 1 diabetes (T1D) based on real-time continuous glucose monitoring (RT-CGM) or self-monitoring of blood glucose (SMBG) combined with multiple daily injections (MDIs) or continuous subcutaneous insulin infusion (CSII). Research Design and Methods: Sixty-five T1D patients were followed up for a year. Of these, 27 started RT-CGM as part of a sensor-augmented insulin regimen (SAIR); within this SAIR group, 15 subjects started sensor-augmented pump (SAP) therapy and the remaining 12 continued with MDIs (MDIs + RT-CGM). A second group of 20 patients initiated CSII without RT-CGM, while a third group of 18 subjects continued on MDIs and SMBG. The main endpoints were reduction of HbA1c, glycemic variability (GV), and incidence of hypoglycemia. Results: After a year, the baseline mean HbA1c in the SAIR group (8.3%) decreased to 7.1% (P < 0.0001); both SAIR subgroups, SAP and MDIs + RT-CGM, showed comparable improvement. The CSII group also had reduced HbA1c (8.4% ± 0.9% vs. 7.9% ± 0.7%; P < 0.05). Both SAIRs were superior to MDIs (P = 0.002) and CSII (P = 0.0032). GV was also lowered, both in the SAIR (P < 0.0001) and CSII (P < 0.05) groups. Reduced incidence of hypoglycemia was observed only with SAIR (8% ± 4% vs. 6% ± 3%; P < 0.01). Conclusion: Both SAIRs, SAP and MDIs + RT-CGM, provided significant and comparable decrease of HbA1c with concurrent reduction of hypoglycemia. This improvement was greater than that seen with CSII. The combination of RT-CGM and MDIs can be a suitable alternative to SAP for some patients. PMID:27482825

  4. Treatment for periodic paralysis

    NARCIS (Netherlands)

    Sansone, [No Value; Meola, G.; Links, T. P.; Panzeri, M.; Rose, M. R.

    2008-01-01

    Background Primary periodic paralyses are rare inherited muscle diseases characterised by episodes of flaccid weakness affecting one or more limbs, lasting several hours to several days, caused by mutations in skeletal muscle channel genes. Objectives The objective of this review was to systematical

  5. The Effects of 52 Weeks of Soccer or Resistance Training on Body Composition and Muscle Function in +65-Year-Old Healthy Males – A Randomized Controlled Trial

    Science.gov (United States)

    Andersen, Thomas Rostgaard; Schmidt, Jakob Friis; Pedersen, Mogens Theisen; Krustrup, Peter; Bangsbo, Jens

    2016-01-01

    The effects of 52 weeks of soccer or resistance training were investigated in untrained elderly men. The subjects aged 68.1±2.1 yrs were randomised into a soccer (SG; n = 9), a resistance (RG; n = 9) and a control group (CG; n = 8). The subjects in SG and RG, respectively, trained 1.7±0.3 and 1.8±0.3 times weekly on average during the intervention period. Muscle function and body composition were determined before and after 16 and 52 weeks of the intervention period. In SG, BMI was reduced by 1.5% and 3.0% (p<0.05) after 16 and 52 weeks, respectively, unchanged in RG and 2% higher (p<0.05) in CG after 52 weeks of the intervention period. In SG, the response to a glucose tolerance test was 16% lower (p<0.05) after 16 wks, but not after 52 wks, compared to before the intervention period, and unchanged in RG and CG. In SG, superoxide dismutase-2 expression was 59% higher (p<0.05) after 52 wks compared to before the intervention period, and unchanged in RG and CG. In RG, upper body lean mass was 3 and 2% higher (p<0.05) after 16 and 52 wks, respectively, compared to before the intervention period, and unchanged in SG and CG. In RG, Akt-2 expression increased by 28% (p<0.01) and follistatin expression decreased by 38% (p<0.05) during the 52-wk intervention period, and was unchanged in SG and CG. Thus, long-term soccer training reduces BMI and improves anti-oxidative capacity, while long-term resistance training impacts muscle protein enzyme expression and increases lean body mass in elderly men. Trial Registration ClinicalTrials.gov: NCT01530035 PMID:26886262

  6. The Effects of 52 Weeks of Soccer or Resistance Training on Body Composition and Muscle Function in +65-Year-Old Healthy Males--A Randomized Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Thomas Rostgaard Andersen

    Full Text Available The effects of 52 weeks of soccer or resistance training were investigated in untrained elderly men. The subjects aged 68.1±2.1 yrs were randomised into a soccer (SG; n = 9, a resistance (RG; n = 9 and a control group (CG; n = 8. The subjects in SG and RG, respectively, trained 1.7±0.3 and 1.8±0.3 times weekly on average during the intervention period. Muscle function and body composition were determined before and after 16 and 52 weeks of the intervention period. In SG, BMI was reduced by 1.5% and 3.0% (p<0.05 after 16 and 52 weeks, respectively, unchanged in RG and 2% higher (p<0.05 in CG after 52 weeks of the intervention period. In SG, the response to a glucose tolerance test was 16% lower (p<0.05 after 16 wks, but not after 52 wks, compared to before the intervention period, and unchanged in RG and CG. In SG, superoxide dismutase-2 expression was 59% higher (p<0.05 after 52 wks compared to before the intervention period, and unchanged in RG and CG. In RG, upper body lean mass was 3 and 2% higher (p<0.05 after 16 and 52 wks, respectively, compared to before the intervention period, and unchanged in SG and CG. In RG, Akt-2 expression increased by 28% (p<0.01 and follistatin expression decreased by 38% (p<0.05 during the 52-wk intervention period, and was unchanged in SG and CG. Thus, long-term soccer training reduces BMI and improves anti-oxidative capacity, while long-term resistance training impacts muscle protein enzyme expression and increases lean body mass in elderly men. Trial Registration: ClinicalTrials.gov: NCT01530035.

  7. Role of psychological reference points in mergers and acquisitions: 52-week high as a reference price in European takeover activity

    OpenAIRE

    Niinivaara, Timo

    2010-01-01

    This thesis examines the role of a target company’s 52-week high stock price as a psychological reference point in mergers and acquisitions. It builds on a new strand of M&A literature linking mergers and acquisitions to psychological considerations. The first objective of this thesis is to test whether the 52-week high acts a psychological reference point in European mergers and acquisitions. To provide added credibility to my findings and to alleviate any concerns for the results arising fr...

  8. Efficacy and Safety of Once-Daily Insulin Degludec/Insulin Aspart versus Insulin Glargine (U100) for 52 Weeks in Insulin-Naïve Patients with Type 2 Diabetes: A Randomized Controlled Trial

    Science.gov (United States)

    Kumar, Ajay; Franek, Edward; Wise, Jonathan; Niemeyer, Marcus; Mersebach, Henriette; Simó, Rafael

    2016-01-01

    Purpose The efficacy and safety of insulin degludec/insulin aspart (IDegAsp) once daily (OD) compared with insulin glargine U100 (IGlar) OD over 52 weeks in insulin-naïve adults with type 2 diabetes mellitus (T2DM) was investigated. Methods In this open-label, parallel-group treat-to-target trial, participants were randomized (1:1) to receive IDegAsp OD (breakfast, n = 266) or IGlar OD (as per label, n = 264). Participants then entered a 26-week extension phase (IDegAsp OD, n = 192; IGlar OD, n = 221). The primary endpoint was change from baseline to Week 26 in HbA1c. Results After 26 and 52 weeks, mean HbA1c decreased to similar levels in both groups. After 52 weeks, the mean estimated treatment difference was –0.08% (–0.26, 0.09 95%CI), confirming the non-inferiority of IDegAsp OD versus IGlar OD evaluated at Week 26. After 52 weeks, there was a similar reduction in mean fasting plasma glucose in both treatment groups. The rate of confirmed hypoglycemic episodes was 86% higher (p administration of IDegAsp with the main meal of the day, tailored to the individual patient’s needs. Trial Registration ClinicalTrials.gov: NCT01045707 [core]) and NCT01169766 [ext] PMID:27760129

  9. Adding 5-hydroxytryptamine receptor type 3 antagonists may reduce drug-induced nausea in poor insight obsessive-compulsive patients taking off-label doses of selective serotonin reuptake inhibitors: a 52-week follow-up case report

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    Martino Matteo

    2010-12-01

    Full Text Available Abstract Poor-insight obsessive-compulsive disorder (PI-OCD is a severe form of OCD where the 'typically obsessive' features of intrusive, 'egodystonic' feelings and thoughts are absent. PI-OCD is difficult to treat, often requiring very high doses of serotonergic drugs as well as antipsychotic augmentation. When this occurs, unpleasant side effects as nausea are common, eventually further reducing compliance to medication and increasing the need for pharmacological alternatives. We present the case of a PI-OCD patient who developed severe nausea after response to off-label doses of the selective serotonin reuptake inhibitor (SSRI, fluoxetine. Drug choices are discussed, providing pharmacodynamic rationales and hypotheses along with reports of rating scale scores, administered within a follow-up period of 52 weeks. A slight reduction of fluoxetine dose, augmentation with mirtazapine and a switch from amisulpride to olanzapine led to resolution of nausea while preserving the anti-OCD therapeutic effect. Mirtazapine and olanzapine have already been suggested for OCD treatment, although a lack of evidence exists about their role in the course of PI-OCD. Both mirtazapine and olanzapine also act as 5-hydroxytryptamine receptor type 3 (5-HT3 blockers, making them preferred choices especially in cases of drug-induced nausea.

  10. DURATION-1: Exenatide Once Weekly Produces Sustained Glycemic Control and Weight Loss Over 52 Weeks

    OpenAIRE

    Buse, John B.; Drucker, Daniel J.; Taylor, Kristin L.; Kim, Terri; Walsh, Brandon; Hu, Hao; Wilhelm, Ken; Trautmann, Michael; Shen, Larry Z.; Porter, Lisa E.; ,

    2010-01-01

    OBJECTIVE In the Diabetes Therapy Utilization: Researching Changes in A1C, Weight and Other Factors Through Intervention with Exenatide Once Weekly (DURATION-1) study, the safety and efficacy of 30 weeks of treatment with the glucagon-like peptide-1 receptor agonist exenatide once weekly (exenatide QW; 2 mg) was compared with exenatide BID in 295 patients with type 2 diabetes. We now report the safety and efficacy of exenatide QW in 1) patients who continued treatment for an additional 22 wee...

  11. A 52-week safety study in cynomolgus macaques for genetically modified rice expressing Cry1Ab/1Ac protein.

    Science.gov (United States)

    Mao, Jie; Sun, Xing; Cheng, Jian-Hua; Shi, Yong-Jie; Wang, Xin-Zheng; Qin, Jun-Jie; Sang, Zhi-Hong; He, Kun; Xia, Qing

    2016-09-01

    A 52-week feeding study in cynomolgus macaques was carried out to evaluate the safety of Bt rice Huahui 1 (HH1), a transgenic rice line expressing Cry1Ab/1Ac protein. Monkeys were fed a diet with 20% or 60% HH1 rice, 20% or 60% parental rice (Minghui 63, MH63), normal diet, normal diet spiked with purified recombinant Cry1Ab/1Ac fusion protein or bovine serum albumin (BSA) respectively. During the feeding trail, clinical observations were conducted daily, and multiple parameters, including body weight, body temperature, electrocardiogram, hematology, blood biochemistry, serum metabolome and gut microbiome were examined at regular intervals. Upon sacrifice, the organs were weighted, and the macroscopic, microscopic and electron microscopic examinations were performed. The results show no adverse or toxic effects of Bt rice HH1 or Cry1Ab/1Ac fusion protein on monkeys. Therefore, the present 52-week primate feeding study suggests that the transgenic rice containing Cry 1Ab/1Ac is equivalent to its parental rice line MH63.

  12. A 52-week safety study in cynomolgus macaques for genetically modified rice expressing Cry1Ab/1Ac protein.

    Science.gov (United States)

    Mao, Jie; Sun, Xing; Cheng, Jian-Hua; Shi, Yong-Jie; Wang, Xin-Zheng; Qin, Jun-Jie; Sang, Zhi-Hong; He, Kun; Xia, Qing

    2016-09-01

    A 52-week feeding study in cynomolgus macaques was carried out to evaluate the safety of Bt rice Huahui 1 (HH1), a transgenic rice line expressing Cry1Ab/1Ac protein. Monkeys were fed a diet with 20% or 60% HH1 rice, 20% or 60% parental rice (Minghui 63, MH63), normal diet, normal diet spiked with purified recombinant Cry1Ab/1Ac fusion protein or bovine serum albumin (BSA) respectively. During the feeding trail, clinical observations were conducted daily, and multiple parameters, including body weight, body temperature, electrocardiogram, hematology, blood biochemistry, serum metabolome and gut microbiome were examined at regular intervals. Upon sacrifice, the organs were weighted, and the macroscopic, microscopic and electron microscopic examinations were performed. The results show no adverse or toxic effects of Bt rice HH1 or Cry1Ab/1Ac fusion protein on monkeys. Therefore, the present 52-week primate feeding study suggests that the transgenic rice containing Cry 1Ab/1Ac is equivalent to its parental rice line MH63. PMID:27338709

  13. Early and Periodic Screening, Diagnosis and Treatment

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    U.S. Department of Health & Human Services — The Early and Periodic Screening, Diagnostic and Treatment (EPSDT) benefit provides comprehensive and preventive health care services for children under age 21 who...

  14. Characteristics and Experiences of Children and Young People with Severe Intellectual Disabilities and Challenging Behaviour Attending 52-Week Residential Special Schools

    Science.gov (United States)

    Pilling, N.; McGill, P.; Cooper, V.

    2007-01-01

    Background: This study sought to gather information about the characteristics and experiences of children and young people with severe intellectual disabilities and severe challenging behaviour attending 52-week residential special schools. Method: Staff of nine schools completed postal questionnaires on the characteristics and experiences of 156…

  15. Efficacy and safety characteristics of mometasone furoate/formoterol fumarate fixed-dose combination in subjects with moderate to very severe COPD: findings from pooled analysis of two randomized, 52-week placebo-controlled trials

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    Tashkin DP

    2012-02-01

    Full Text Available Donald P Tashkin1, Dennis E Doherty2, Edward Kerwin3, Carlos E Matiz-Bueno4, Barbara Knorr5, Tulin Shekar5, Davis Gates5, Heribert Staudinger51David Geffen School of Medicine at UCLA, Los Angeles, CA, 2Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky, Lexington, KY, 3Clinical Research Institute of Southern Oregon, Medford, OR, USA; 4Fundación Salud Bosque, Bogota, Colombia, 5Merck Sharp & Dohme Corp, Whitehouse Station, NJ, USABackground: The clinical efficacy and safety of a mometasone furoate/formoterol fumarate (MF/F fixed-dose combination formulation administered via a metered-dose inhaler was investigated in patients with moderate to very severe chronic obstructive pulmonary disease (COPD.Methods: Two 52-week, multicenter, double-blind, placebo-controlled trials with identical study designs were conducted in current or ex-smokers (aged ≥40 years, and pooled study results are presented herein. Subjects (n = 2251 were randomized to 26 weeks of twice-daily treatment with MF/F 400/10 µg, MF/F 200/10 µg, MF 400 µg, F 10 µg, or placebo. After the 26-week treatment period, placebo subjects completed the trial and 75% of subjects on active treatment entered a 26-week safety extension. Coprimary efficacy variables were mean changes in forced expiratory volume in one second (FEV1, area under the curve from 0 to 12 hours postdose (AUC0–12 h, and morning predose/trough FEV1 from baseline to the week 13 endpoint. Key secondary efficacy variables were St George’s Respiratory Questionnaire scores, symptom-free nights, time-to-first exacerbation, and partly stable COPD at the week 26 endpoint.Results: In the 26-week treatment period, significantly greater increases in FEV1 AUC0–12 h occurred with MF/F 400/10 versus MF 400 and placebo at the week 13 and week 26 endpoints (P ≤ 0.032. These increases were over three-fold greater with MF/F 400/10 than with MF 400. Also, significantly greater increases in morning

  16. Treatment delay period: the case of arsenicosis in rural Bangladesh.

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    Paul, Bimal Kanti; Brock, Vicki L Tinnon

    2006-12-01

    Arsenic concentrations of tubewell water that exceed acceptable limits poses a serious health problem in Bangladesh. Many Bangladeshis are now suffering from arsenic-related diseases. The objectives of this paper are to examine the extent of delay in seeking medical treatment by victims of arsenic poisoning and to identify factors contributing to this delay. Questionnaire survey successfully administered to 663 victims living in two rural areas of Bangladesh provided the major data source for this study. Analysis of survey data reveal that median delay period was 12 months, but the delay period ranged from 1 month to 18 years. Because of this extremely large range, the mean delay period was about 22 months. The study identified time of identification of symptoms of arsenicosis as the most significant determinant of treatment delay followed by treatment sought from members of mobile medical teams, perceived threat, and level of education. Based on the study findings, it is recommended that the Bangladesh government and NGOs involved in arsenic mitigation and prevention efforts should educate individuals at risk for arsenic poisoning about the benefits of seeking early treatment. This study also recommends to continue to dispatch mobile medical teams to the arsenic-impacted areas.

  17. Surgical treatment for thyrotoxic hypokalemic periodic paralysis: case report

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    Lin Yi-Chu

    2012-01-01

    Full Text Available Abstract Thyrotoxic hypokalemic periodic paralysis (THPP is a rare, potentially life-threatening endocrine emergency. It is characterized by recurrent muscle weakness and hypokalemia. Because many THPP patients do not have obvious symptoms and signs of hyperthyroidism, misdiagnosis may occur. The published studies revealed that definitive therapy for THPP is control of hyperthyroidism by medical therapy, radioactive iodine or surgery, but the long-term post-operative follow-up result was not observed. We reported two cases of medically refractory THPP with recurrent paralysis of extremities and hypokalemia, and both were combined with thyroid nodules. Both patients were treated with total thyroidectomy; the pathology revealed that one is Graves' disease with thyroid papillary carcinoma, and the other is adenomatous goiter with papillary hyperplasia. No episode of periodic paralysis was noted and laboratory evaluation revealed normal potassium level during the post-operative follow up. Our experience suggests that total thyroidectomy by experienced surgeon is an appropriate and definite treatment for medically refractory THPP, especially in cases combined with thyroid nodules.

  18. Periodization

    OpenAIRE

    Lorenz, Daniel S.; Reiman, Michael P.; Walker, John C.

    2010-01-01

    Background: Clinicians are constantly faced with the challenge of designing training programs for injured and noninjured athletes that maximize healing and optimize performance. Periodization is a concept of systematic progression—that is, resistance training programs that follow predictable patterns of change in training variables. The strength training literature is abundant with studies comparing periodization schemes on uninjured, trained, and untrained athletes. The rehabilitation litera...

  19. Alveolar proteinosis: diagnosis and treatment over a 10-year period.

    OpenAIRE

    du Bois, R M; McAllister, W A; Branthwaite, M A

    1983-01-01

    Ten years' experience of using bronchoalveolar lavage in the treatment of 10 patients with alveolar proteinosis is reported. The diagnosis was often missed. The interval between onset of symptoms and diagnosis varied from six weeks to six years (median 2 years), so that the start of treatment was often delayed. Some patients experienced severe progressive disability before they had treatment. Whole-lung lavage proved to be a safe, repeatable procedure which provided symptomatic, physiological...

  20. Familial gastric cancer : guidelines for diagnosis, treatment and periodic surveillance

    NARCIS (Netherlands)

    Kluijt, Irma; Sijmons, Rolf H.; Hoogerbrugge, Nicoline; Plukker, John T.; de Jong, Daphne; van Krieken, J. Han; van Hillegersberg, Richard; Ligtenberg, Marjolijn; Bleiker, Eveline; Cats, Anemieke

    2012-01-01

    Hereditary diffuse gastric cancer (HDGC) is a relatively rare disorder, with a mutated CDH1 gene as the only known cause. Carriers of a germline mutation in CDH1 have a lifetime risk of > 80% of developing diffuse gastric cancer. As periodic gastric surveillance is of limited value in detecting earl

  1. [Familial gastric cancer: diagnosis, treatment and periodic surveillance

    NARCIS (Netherlands)

    Kluijt, I.; Sijmons, R.H.; Hoogerbrugge, N.; Vasen, H.F.; Cats, A.

    2011-01-01

    The only known genetic causes of hereditary diffuse gastric cancer (HDGC) are germline mutations in the CDH1 gene.- CDH1 mutation carriers have a lifetime risk of 70-80% of developing diffuse gastric cancer. As periodic gastric surveillance is of limited value in detecting early stages of HDGC, prop

  2. Treatment with an orthopedic appliance system in relation to treatment intensity and growth periods. A study of initial effects.

    Science.gov (United States)

    Malmgren, O; Omblus, J; Hägg, U; Pancherz, H

    1987-02-01

    The study comprises an analysis of the effect of treatment with a modified activator combined with a high-pull headgear during a standardized observation period of the initial 6 months of treatment. All patients (24 girls and 32 boys, aged 8.5 to 15 years) had severe skeletal Class II malocclusion. In the first part of the study, the effect of treatment with the appliance both day and night is compared with the effect when it was worn only at night. Only a small and nonsignificant difference was found, but the patients tended to cooperate better if they were instructed to wear the appliance continuously. In the second part of the study, the effect of treatment is related to the somatic maturation of the patients. Longitudinal records of standing height were used to assess whether treatment had been performed before maximal pubertal growth (prepeak period), during maximal pubertal growth (peak period), or after maximal pubertal growth (postpeak period). The skeletal effect was significantly greater in boys treated during the peak period than in those treated during the prepeak period and a similar tendency, although not significant, was found among girls. The number of patients treated during the postpeak period was too small for statistical analysis.

  3. Periodicity in cell dynamics in some mathematical models for the treatment of leukemia

    Science.gov (United States)

    Halanay, A.

    2012-11-01

    A model for the evolution of short-term hematopoietic stem cells and of leukocytes in leucemia under periodic treatment is introduced. It consists of a system of periodic delay differential equations and takes into consideration the asymmetric division. A guiding function is used, together with a theorem of Krasnoselskii, to prove the existence of a strictly positive periodic solution and its stability is investigated.

  4. Fluctuations induced extinction and stochastic resonance effect in a model of tumor growth with periodic treatment

    Energy Technology Data Exchange (ETDEWEB)

    Li Dongxi, E-mail: lidongxi@mail.nwpu.edu.c [Department of Applied Mathematics, Northwestern Polytechnical University, Xi' an 710072 (China); Xu Wei; Guo, Yongfeng; Xu Yong [Department of Applied Mathematics, Northwestern Polytechnical University, Xi' an 710072 (China)

    2011-01-31

    We investigate a stochastic model of tumor growth derived from the catalytic Michaelis-Menten reaction with positional and environmental fluctuations under subthreshold periodic treatment. Firstly, the influences of environmental fluctuations on the treatable stage are analyzed numerically. Applying the standard theory of stochastic resonance derived from the two-state approach, we derive the signal-to-noise ratio (SNR) analytically, which is used to measure the stochastic resonance phenomenon. It is found that the weak environmental fluctuations could induce the extinction of tumor cells in the subthreshold periodic treatment. The positional stability is better in favor of the treatment of the tumor cells. Besides, the appropriate and feasible treatment intensity and the treatment cycle should be highlighted considered in the treatment of tumor cells.

  5. High-dose-rate interstitial brachytherapy for gynecologic malignancies. Dosimetric changes during treatment period

    International Nuclear Information System (INIS)

    The purpose of this study was to overcome cranio-caudal needle displacement in pelvic high-dose-rate interstitial brachytherapy (HDRIB), we have been utilizing a fullystretched elastic tape to thrust the template into the perineum. The purpose of the current study was to evaluate dosimetric changes during the treatment period using this thrusting method, and to explore reproducible planning methods based on the results of the dosimetric changes. Twenty-nine patients with gynecologic malignancies were treated with HDRIB at the Cancer Institute Hospital. Pre-treatment and post-treatment computed tomography (CT) scans were acquired and a virtual plan for post-treatment CT was produced by applying the dwell positions/times of the original plan. For the post-treatment plan, D90 for the clinical target volume (CTV) and D2cc for the rectum and bladder were assessed and compared with that for the original plan. Cranio-caudal needle displacement relative to CTV during treatment period was only 0.7±1.9 mm. The mean D90 values for the CTV in the pre- and post-treatment plans were stable (6.8 Gy vs. 6.8 Gy) and the post-treatment/pre-treatment D90 ratio was 1.00±0.08. The post-/pre-treatment D2cc ratio was 1.14±0.22 and the mean D2cc for the rectum increased for the post-treatment plan (5.4 Gy vs. 6.1 Gy), especially when parametrial infiltration was present. The mean D2cc for the bladder was stable (6.3 Gy vs. 6.6 Gy) and the ratio was 1.06±0.20. Our thrusting method achieved a stable D90 for the CTV, in contrast to previous prostate HDRIB reports displaying reductions of 35-40% for D90 during the treatment period. (author)

  6. Analysis of incidence and treatment of pneumothorax in five-year period in Kragujevac

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    Milisavljević Slobodan

    2012-01-01

    Full Text Available Introduction. Pneumothorax is a common clinical problem in thoracic surgery. Leading professional associations have adopted a number of guidelines and recommendations for the treatment of pneumothorax, but their clinical use is often insufficient. This study was aimed at analyzing the incidence of pneumothorax, profile of patients and surgical treatment of pneumothorax at the Clinical Center Kragujevac, in a five-year period. Material an methods. This retrospective, non-interventional study used data collected from the medical records and operative protocol of the Department of Thoracic Surgery, Clinical Centre Kragujevac in a fiveyear period. All data were statistically analyzed. Results. In the observed period, 492 patients with diagnosis of pneumothorax were hospitalized. The majority of patients were treated in 2009 (140, and the fewest in 2005 (68. Four-fifths of patients were male. Primary spontaneous pneumothorax was found in 25% and traumatic pneumothorax in 50%. Most patients were aged 21-30 years (83. The number of cases of secondary spontaneous and traumatic pneumothorax increased with the age of patients and the number of cases of primary and recurrent spontaneous pneumothorax decreased with their age. Drainage as a method of treatment was prevalent in all types of pneumothorax (p < 0.01. Conclusion. The results of study show similarities with other studies regarding both the incidence of certain forms of pneumothorax and the gender-age profile of patients and their treatment, taking into account the observed period and the target population.

  7. Effects of mometasone furoate/formoterol fumarate fixed-dose combination formulation on chronic obstructive pulmonary disease (COPD: results from a 52-week Phase III trial in subjects with moderate-to-very severe COPD

    Directory of Open Access Journals (Sweden)

    Doherty DE

    2012-02-01

    Full Text Available Dennis E Doherty1, Donald P Tashkin2, Edward Kerwin3, Barbara A Knorr4, Tulin Shekar4, Sibabrata Banerjee4, Heribert Staudinger41Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky, Lexington, KY, 2David Geffen School of Medicine at UCLA, Los Angeles, CA, 3Clinical Research Institute of Southern Oregon, Medford, OR, 4Merck Sharp & Dohme Corp, Whitehouse Station, NJ, USARationale: The purpose of this study was to investigate the clinical efficacy and safety of a fixed-dose combination of mometasone furoate/formoterol fumarate (MF/F administered via a metered-dose inhaler in subjects with moderate-to-very severe chronic obstructive pulmonary disease (COPD.Methods: This multicenter, double-blind, placebo-controlled trial had a 26-week treatment period and a 26-week safety extension. Subjects (n = 1196, at least 40 years old, were current or ex-smokers randomized to twice-daily inhaled MF/F 400/10 µg, MF/F 200/10 µg, MF 400 µg, F 10 µg, or placebo. The trial’s co-primary endpoints were mean changes from baseline, as area under the curve (AUC, in forced expiratory volume (FEV1 over 0–12 hours (AUC0-12 h FEV1 with MF/F versus MF, and in morning (AM pre-dose (trough FEV1 with MF/F versus F after 13 weeks of treatment. Key secondary endpoints were the effects of MF/F on respiratory health status using the Saint George’s Respiratory Questionnaire (SGRQ, symptom-free nights, partly stable COPD at 26 weeks, and time to first COPD exacerbation.Results: The largest improvements in AUC0-12 h FEV1 were observed with MF/F 400/10 µg and MF/F 200/10 µg. Serial spirometry results demonstrated that bronchodilator effects with MF/F occurred rapidly (within 5 minutes, persisted for 12 hours after dosing, and were sustained over the 26-week treatment period. Similar findings were observed for AM pre-dose FEV1, for which effects were further investigated, excluding subjects whose AM FEV1 data were incorrectly collected after 2

  8. Efficacy and safety of a fixed-dose combination of mometasone furoate and formoterol fumarate in subjects with moderate to very severe COPD: results from a 52-week Phase III trial

    Directory of Open Access Journals (Sweden)

    Tashkin DP

    2012-02-01

    Full Text Available Donald P Tashkin1, Dennis E Doherty2, Edward Kerwin3, Carlos E Matiz-Bueno4, Barbara Knorr5, Tulin Shekar5, Sibabrata Banerjee5, Heribert Staudinger51David Geffen School of Medicine at UCLA, Los Angeles, CA, 2Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky, Lexington, KY, 3Clinical Research Institute of Southern Oregon, Medford, OR USA; 4Fundación Salud Bosque, Bogota, Colombia; 5Merck Sharp & Dohme Corp, Whitehouse Station, NJ USABackground: A clinical trial of mometasone furoate/formoterol fumarate (MF/F administered via a metered-dose inhaler in subjects with moderate to very severe chronic obstructive pulmonary disease (COPD investigated the efficacy and safety of a fixed-dose combination of MF/F.Methods: This multicenter, double-blind, placebo-controlled trial had a 26-week treatment period and a 26-week safety extension. Subjects (n = 1055; ≥40 years were current or ex-smokers randomized to twice-daily treatment with inhaled MF/F 400/10 µg, MF/F 200/10 µg, MF 400 µg, F 10 µg, or placebo. The coprimary endpoints of the trial were mean changes from baseline in forced expiratory volume in 1 second (FEV1 over 0–12 hours (AUC0–12 FEV1 with MF/F versus MF, and in morning predose FEV1 with MF/F versus F. Key secondary endpoints were quality of life (Saint George’s Respiratory Questionnaire [SGRQ], symptom-free nights, and partly stable COPD at 26 weeks, as well as time to first COPD exacerbation.Results: Significant improvements in FEV1 AUC0–12 occurred at endpoint with MF/F 400/10 and MF/F 200/10 versus MF 400 (P ≤ 0.007. Significant bronchodilation occurred in 5 minutes with MF/F, and serial spirometry demonstrated sustained FEV1 improvements with MF/F over the treatment period. Significant improvements in morning predose FEV1 occurred with both MF/F doses, and these effects were further investigated by excluding results for subjects whose morning FEV1 data were collected >2 days after the last

  9. Stress perception among patients in pre-colonoscopy period and those undergoing chemotherapy treatment

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    Graziela de Souza Alves da Silva

    2015-05-01

    Full Text Available Objective: comparing the perception of stress among patients with colorectal cancer undergoing chemotherapy with those in pre-colonoscopy period. Methods: a comparative descriptive study developed with 144 people receiving chemotherapy and 100 patients in the pre-colonoscopy period, using biosocial and clinical data, Stress Assessment Tool and Perceived Stress Scale. Results: a predominance of females (73%, aged over 65 (50% were predominant for the pre-colonoscopy period patients. In patients receiving chemotherapy, gender parity with ages ranging from 40-64 years (68.1% was observed. Pre-colonoscopy patients showed higher perceived stress compared to those receiving chemotherapy (p <0.001. Conclusion: the phase of diagnostic definition represents greater stress to patients in comparison to period of treatment, even despite the characteristic manifestations of chemotherapy.

  10. Regeneration of Aqueous Periodate Solutions by Ozone Treatment: A Sustainable Approach for Dialdehyde Cellulose Production.

    Science.gov (United States)

    Koprivica, Slavica; Siller, Martin; Hosoya, Takashi; Roggenstein, Walter; Rosenau, Thomas; Potthast, Antje

    2016-04-21

    A method for easy and fast regeneration of aqueous periodate solutions from dialdehyde cellulose (DAC) production by ozone treatment is presented, along with a direct and reliable simultaneous quantification of iodate and periodate by reversed-phase HPLC. The influence of iodate and ozone concentration, solution pH, and reaction time on the regeneration efficiency was studied, as well as the reaction kinetics. Regeneration of spent periodate solutions by ozone was successfully performed in alkaline medium, which favors the formation of free (.) OH radicals, as supported by the addition of radical scavengers and quantum mechanical calculations. At pH 13 and an ozone concentration of approximately 150 mg L(-1) , periodate was completely regenerated from a 100 mm solution of iodate within 1 h at room temperature. A cyclic process of cellulose oxidation and subsequent regeneration of spent periodate with 90 % efficiency has been developed. So far, commercial applications of DAC have been hampered by difficulties in reusing the costly periodate. This work overcomes this hurdle and presents a highly efficient, clean, and low-cost protocol for the preparation of DAC with integrated periodate recycling, with the possibility of scaling the process up.

  11. Treatment of Class II, Division 2 in the late growth period.

    Science.gov (United States)

    Eberhard, H; Hirschfelder, U

    1998-01-01

    The "Deckbiss" with skeletal Class II jaw relationship sometimes presents a considerable therapeutic problem, particularly in the late growth period (DP3U), as regards the coordination of dental and skeletal treatment objectives. An effective treatment approach was demonstrated: a modified Herbst appliance used simultaneously with fixed appliances in the maxilla. The sample comprised 12 male (14.0 +/- 0.9 years old) and 10 female (12.3 +/- 0.4 years old) patients. Correction of the distal occlusion was achieved in all patients by means of the Herbst appliance, which was removed after an average time period of 6.4 +/- 0.2 months. In the mandible the multibracket appliances were then immediately inserted, and Class II elastics were used for retention. Maximum anchorage was required in the maxilla as well as in the mandible. Complete diagnostic records were made at the beginning of the treatment as well as 6 and 12 months later, in order to document skeletal and dental changes. A dental and skeletal Class I relationship was achieved in all cases. A significant improvement was recorded in the vertical jaw base relationship; this was still stable after a period of 12 months. In the dental area in particular, a so-called high-pull headgear effect (intrusion and distalization 16, 26) and intrusion of teeth 34, 44 were registered. Only a minor protrusion of the mandibular incisors was observed. Reinforcement of the bands reduced the failure rate significantly. The Herbst appliance does not represent a standard treatment for Class II. Its indication range is limited.

  12. APPLICATION OF PULSE-PERIODICAL MODE FOR IMPROVEMENT OF LASER TREATMENT EFFICIENCY

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    V. V. Apollonov

    2014-01-01

    Full Text Available The purpose of the paper is to estimate an application of pulse-periodical mode for improvement of laser treatment efficiency. Laser technologies have been widely used in the processes of material treatment with the purpose to provide them the required surface properties and also for high accuracy cutting of sheet materials. Application of complex treatment is of great interest and especially when it is used for worn-out surfaces with formation of a coating by gas-flame laying of powder mixture of specific composition and subsequent laser fusion.Increase of laser unit capacity is very important task for higher efficiency of laser technology application in mechanical engineering. Nowadays technological processes using lasers with high average power (more than 100 W have been applying only sources that are working in two modes, namely: continuous and pulse- periodical (P-P with pulse repetition rate from some units to several hundred hertz and pulse duration within dozens to hundreds of microseconds and even within milliseconds. On the other hand, in some cases shielding effect of plasma cloud formed during laser alloying, cladding or welding reduces the efficiency of laser treatment up to 50 % depending on plasma composition and laser beam length. High frequency P-P laser systems with high average power working in mode of Q-factor modulation allow to realize principally other mechanism of irradiation interaction with materials that is an ablation. In this case it is possible to provide local energy release both in space and time.The performed analysis has revealed that P-P mode of laser operation for a majority of treatment processes is much better and more efficient from energetic point of view in comparison with the continuous mode. On the basis of the developments it is possible to make a conclusion that there is a possibility to create laser systems working in high frequency P-P mode with high average power above hundreds watt.

  13. Combination quetiapine therapy in the long-term treatment of patients with bipolar I disorder

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    Calabrese JR

    2005-07-01

    Full Text Available Abstract Objective Determine the long-term effectiveness of quetiapine in combination with standard treatments in preventing relapses for patients with bipolar I disorders Method Twenty-one outpatients with type I bipolar disorder who had inadequate responses to ongoing standard therapies were treated with add-on quetiapine in an open-label study. The quetiapine dose was increased until clinical response occurred. Illness response was assessed using the Clinical Global Impression (CGI scale. Relapse rates before and during quetiapine treatment were compared by calculating incidence risk ratios. Results Quetiapine was added to ongoing standard therapy for 26 to 78 weeks. Thirteen patients received combination therapy for at least 52 weeks. The mean quetiapine dose received was 518 ± 244 mg/day. There were highly significant improvements in overall relapse rate, manic/mixed relapse rate, and depression relapse rate in the period during quetiapine treatment compared with the period before quetiapine was initiated. The calculated relative risk of relapse in the absence of quetiapine treatment was 2.9 overall (95% confidence interval, 1.5~5.6, 3.3 for manic/mixed relapse (95% confidence interval, 1.5~7.1, and 2.4 for depressive relapse (95% confidence interval, 1.3~4.4. The mean Clinical Global Impression scores improved significantly from baseline during 26 weeks of quetiapine treatment in 21 patients (p = 0.002 and remained significantly better during a 52-week treatment period in 13 patients (p = 0.036. Conclusion Long-term treatment with quetiapine combination therapy reduced the probability of manic/mixed and depressive relapses and improved symptoms in patients with bipolar I disorder who had inadequate responses to ongoing standard treatment.

  14. Meaning of leprosy for people who have experienced treatment during the sulfonic and multidrug therapy periods

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    Karen da Silva Santos

    2015-08-01

    Full Text Available AbstractObjective: to analyze the meanings of leprosy for people treated during the sulfonic and multidrug therapy periods.Method: qualitative nature study based on the Vigotski's historical-cultural approach, which guided the production and analysis of data. It included eight respondents who have had leprosy and were submitted to sulfonic and multidrug therapy treatments. The participants are also members of the Movement for Reintegration of People Affected by Leprosy.Results: the meanings were organized into three meaning cores: spots on the body: something is out of order; leprosy or hanseniasis? and leprosy from the inclusion in the Movement for Reintegration of People Affected by Leprosy.Conclusion: the meanings of leprosy for people submitted to both regimens point to a complex construction thereof, indicating differences and similarities in both treatments. Health professionals may contribute to the change of the meanings, since these are socially constructed and the changes are continuous.

  15. Evaluating the Efficacy of Primary Treatment for Graves’ Disease Complicated by Thyrotoxic Periodic Paralysis

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    Rita Yuk-Kwan Chang

    2014-01-01

    Full Text Available Objective. Thyrotoxic periodic paralysis (TPP is a potentially life-threatening complication of Graves’ disease (GD. The present study compared the long-term efficacy of antithyroid drugs (ATD, radioactive iodine (RAI, and surgery in GD/TPP. Methods. Sixteen patients with GD/TPP were followed over a 14-year period. ATD was generally prescribed upfront for 12–18 months before RAI or surgery was considered. Outcomes such as thyrotoxic or TPP relapses were compared between the three modalities. Results. Eight (50.0% patients had ATD alone, 4 (25.0% had RAI, and 4 (25.0% had surgery as primary treatment. Despite being able to withdraw ATD in all 8 patients for 37.5 (22–247 months, all subsequently developed thyrotoxic relapses and 4 (50.0% had ≥1 TPP relapses. Of the four patients who had RAI, two (50% developed thyrotoxic relapse after 12 and 29 months, respectively, and two (50.0% became hypothyroid. The median required RAI dose to render hypothyroidism was 550 (350–700 MBq. Of the 4 patients who underwent surgery, none developed relapses but all became hypothyroid. Conclusion. To minimize future relapses, more definitive primary treatment such as RAI or surgery is preferred over ATD alone. If RAI is chosen over surgery, a higher dose (>550 MBq is recommended.

  16. Treatment of bronchial asthma with low-level laser in attack-free period at children

    Science.gov (United States)

    Ailioaie, C.; Ailioaie, Laura

    2000-06-01

    Bronchial asthma is a common disease in both the pediatric and adult populations, characterized by wide variations over short periods of time in resistance to airflow in intrapulmonary airways. A primary goal in the use of low- level laser therapy (LLLT) was the safe, effective and rapid palliation of symptoms owing to tracheal or bronchial obstruction. We have investigated the effects of LLLT comparatively with other modality trials in children's asthma. In the study were included 98 patients aged 10-18 years diagnosed with moderate or severe asthma, in attack- free period. The patients were divided into 3 groups. Group 1 received only laser therapy using extra meridian acupuncture points and scanning technique. Group 2 was treated only with inhaled Serevent 2 X 25 micrometers , two times daily, 3 months. Group 3 was tread with Theophylline retard in dosage of 15-mg/kg/12 h, 3 months. At the end of treatment we remarked a noticeable improvement of the clinical, functional and immunological characteristics at 83 percent of patients in group 1, comparatively with only 70 percent (group 2) and 53 percent (group 3). The LLLT had a very good action on bronchial patency , displayed an immunocorrecting action and is recommended in attack-free periods at children.

  17. Obsessive-compulsive disorder in the perinatal period: epidemiology, phenomenology, pathogenesis, and treatment

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    Álvaro Frías

    2015-01-01

    Full Text Available The aim of this review is to describe the main theoretical findings and research conclusions about obsessive-compulsive disorder (OCD in the perinatal period. On one hand, epidemiological studies show that the risk of OCD onset and/or exacerbation could increase in this period, particularly in the puerperium. Phenomenologically, in this stage aggressive and contamination obsessions are very common and are related to the fetus or newborn. On the other hand, regarding OCD pathogenesis in this period, there is indirect evidence to suggest the participation of neuroendocrine (e.g. female gonadal steroids and oxytocin and cognitive behavioural variables (e.g. hyper-responsibility, threat overestimation, and mental control. In terms of research, more empirical studies are needed to contrast these specific vulnerability factors. Moreover, no empirically validated psychotherapeutic treatments (controlled trials adapted to this OCD sub-group were found, although some studies highlight the role of cognitive behavioural therapy (CBT as an effective intervention in the context of selective primary prevention.

  18. [Anemia and its treatment with peroral anti-anemia agents in women during the postpartum period].

    Science.gov (United States)

    Mára, M; Eretová, V; Zivný, J; Kvasnicka, J; Umlaufová, A; Márová, E

    1999-06-01

    The prevalence of anaemia during pregnancy and post partum is according to the literature and many years clinical experience high. In the submitted work we investigated the incidence of sideropenic anaemia in women during the first three months after a spontaneous delivery, changes of clinical and laboratory indicators of anaemia during this period and the possible effect exerted by administration of iron and iron plus folic acid resp. Ninety pregnant women in the 35th to 39th week of pregnancy were at random divided into three equally sized groups and the following were assessed: haemogram, indicators of iron reserves, serum concentrations of folic acid, vitamin B12, erythropoetin and soluble transferrin receptor, liver tests, total protein + electrophoresis, acute stage proteins. In the first group (T) the women were given, starting on the 4th day after delivery 1 tablet of Tardyferon per day for two months. To the second group (F) for an equal period 1 tablet of Tardyferon Fol per day was administered. Women in the control group (K) had no medication. In the investigation women with medium and severe pregnancy anaemia were not included nor women taking during pregnancy or previously iron preparations or those treated in the past by blood transfusion. After spontaneous delivery (women who had Caesarean section or forceps delivery were eliminated from the study) the women were subjected to the same examinations as before delivery. These examinations were made on the fourth day after delivery and then after monthly intervals for a period of three months. At the same time the subjective condition of the mothers was evaluated after delivery, focused on the development of symptoms typical for anaemia and the possible effect of administered treatment. The investigation was completed by 60 women. During treatment no allergic or other serious side-reactions to the administered drugs calling for discontinuation of treatment were recorded. The results of the investigation

  19. Induction of ovarian activity in Bulgarian Murrah buffaloes by hormonal treatment in the early postpartum period

    Institute of Scientific and Technical Information of China (English)

    Stanimir A Yotov; Anatoli S Atanasov; Yordanka Y Ilieva

    2013-01-01

    Objective: To determine the possibilities for induction of ovarian activity in Bulgarian Murrah buffaloes by hormonal treatment in the early postpartum period. Methods: Twenty six clinically healthy animals, weighing 480-520 kg, 3-5 years of age, with normal parturition, without clinical signs of endometritis during the entire experimental period were divided into 2 groups: control (n=10) and experimental (n=16). Primiparous and multiparous buffaloes were proportionally allotted into both groups. By 5, 21, and 28 postpartum days, control animals were intramuscularly treated with 2 mL physiological saline, whereas experimental buffaloes received 500 mg PGF2αby the 5th postpartum day, 100 μg GnRH by the 21st postpartum day and a second prostaglandin dose 7 days later. All buffaloes were submitted to transrectal ultrasound examination on days 5, 21 and 28 after calving. Evaluation of ovarian activity was made on the basis of follicle type and detection of a newly formed corpus luteum. The percentage of animals with small, medium or dominant follicle and corpus luteum after either spontaneous or induced ovulation was determined. Insemination management included introduction of two proven fertile bulls into the herd at the start of the treatment. Pregnancy ultrasound checks were performed on postpartum days 58, 68, 120 and 150. The proportion of buffaloes with clinical signs of spontaneous or induced oestrus until the 35th postpartum day, pregnancy rates by the 35th and 90th postpartum days and service periods 90 days were registered. Results: On the 5th day after calving, small follicles were predominating in the ovaries of buffaloes from both groups. Similar findings were established on the 21st day in the control group, whereas the share of experimental buffaloes with small follicles was significantly (P<0.01) lower. By the 21st day, there were no medium follicles in untreated animals, while in hormonally treated ones they were found out in 25% of cases. The

  20. Interleukin-1 antagonists in the treatment of autoinflammatory syndromes, including cryopyrin-associated periodic syndrome

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    Pierre Quartier

    2011-01-01

    Full Text Available Pierre QuartierUnité d'Immunologie-Hématologie et Rhumatologie pédiatriques, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, FranceAbstract: Cryopyrin-associated periodic syndrome (CAPS include a group of rare autoinflammatory disorders, the spectrum of which ranges from the mildest form, ie, familial cold autoinflammatory syndrome to more severe phenotypes, ie, Muckle-Wells syndrome, and chronic infantile neurological cutaneous and articular syndrome, also known as neonatal-onset multisystem inflammatory disease. Three interleukin (IL-1 antagonists have been tested in adults and children with CAPS, ie, anakinra, a recombinant homolog of the human IL-1 receptor antagonist; rilonacept, a fusion protein comprising the extracellular domains of IL-1 receptor I and the IL-1 adaptor protein, IL-1RAcP, attached to a human immunoglobulin G molecule; and canakinumab, the anti-IL-1β monoclonal antibody. Following rapid clinical development, rilonacept and canakinumab were approved by both the US Food and Drug Administration and the European Medicines Agency for use in adults and children. This review describes how the study of CAPS has helped us to understand better the way the innate immune system works, the pathogenesis of autoinflammatory syndromes, and the key role of IL-1. It also reviews the effects of IL-1 blockade in CAPS and other disorders, in particular systemic juvenile idiopathic arthritis, adult-onset Still's disease, and gout. Finally, this review covers some issues addressed by very recent and ongoing work regarding treatment indications, from orphan diseases to common disorders, continuous versus intermittent treatment, the pharmacokinetics, pharmacodynamics, and optimal dosages of the different drugs, as well as the need for Phase IV trials, exhaustive registries, and long-term follow-up of several patient cohorts.Keywords: inflammation, interleukin-1, cytokines, treatment

  1. Metabolic observations during the treatment of obese patients by periods of total starvation

    NARCIS (Netherlands)

    Riet, H.G. van; Schwarz, F.; Kinderen, P.J. der; Veeman, W.

    1964-01-01

    Ten very obese female patients were treated by periods of total starvation lasting 10 days each. In the interval between these starvation periods, a diet of 600 calories was given. Twenty-one periods were completed, 6 patients went through 3 periods each. The fasting was generally well tolerated; wi

  2. ANALYSIS OF RANGE CONDITIONS OF CHILDREN WITH SPEECH DIFFICULTIES WITH SPEECH THERAPY TREATMENT AT PRE-SCHOOL PERIOD

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    V. MIRAKOVSKA

    1997-12-01

    Full Text Available An analysis for range of children with speech difficulties in their development with speech therapy treatment is made for a period of 3 years ( 1993-1996 in the Institute for hearing, speech and voice in Skopje. The obtained results from the analysis show that “ for the time the children have to go to school, parent’s interest in their children’s speech is increased. About 90 % of the children ranged with speech therapy treatment, in that period they were at 5-7 years of age, and that shows that a part of the utmost period for development of the speech is missed.Also a great number of children with speech difficulties in their development were not ranged with speech therapy treatment. The reasons for that are the late directing of children, the social and cultural factor, economic condition of the family.

  3. Period of remission after treatment with UVA-1 in sclerodermic skin diseases.

    NARCIS (Netherlands)

    Kroft, E.B.M.; Kerkhof, P.C.M. van de; Gerritsen, M.J.P.; Jong, E.M.G.J. de

    2008-01-01

    BACKGROUND: Sclerodermic skin diseases can cause severe morbidity and disability. UVA-1 has shown to be an effective therapy for sclerodermic skin diseases. However, the period of remission in these patients is not clear. In this study, the effect and remission period of UVA-1 phototherapy in variou

  4. Use of antidepressants in the treatment of major depressive disorder in primary care during a period of economic crisis

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    Sicras-Mainar A

    2015-12-01

    Full Text Available Antoni Sicras-Mainar,1 Ruth Navarro-Artieda2 1Research Unit, Badalona Serveis Assistencials SA, 2Medical Documentation Unit, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain Objective: To describe antidepressant (AD use in the treatment of major depressive disorder during a period of economic crisis.Patients and methods: This was a retrospective, observational study using population-based databases. Two periods were considered: 1 2008–2009, precrisis, and 2 2012–2013, economic crisis. Certain inclusion/exclusion criteria were taken into account for the study (initiation of AD treatment. Patients were followed up for 12 months. The main measures were use (defined daily doses, epidemiologic measures, strategies used and treatment persistence, referrals, and use of resources. Statistical significance was set at P<0.05.Results: In the precrisis period, 3,662 patients were enrolled, and 5,722 were enrolled in the period of economic crisis. Average age was 58.8 years and 65.4% were women. Comparing the two periods, major depressive disorder prevalence was 5.4% vs 8.1%, P<0.001. During the period of economic crisis, AD use rose by 35.2% and drug expenditures decreased by 38.7%. Defined daily dose per patient per day was 10.0 mg vs 13.5 mg, respectively, P<0.001. At 12-month follow-up, the majority of patients (60.8% discontinued the treatment or continued on the same medication as before, and in 23.3% a change of AD was made.Conclusion: Primary health care professionals are highly involved in the management of the illness; in addition, during the period of economic crisis, patients with major depressive disorder showed higher rates of prevalence of the illness, with increased use of AD drugs. Keywords: consumption, antidepressants, economic crisis

  5. Short and long period optimization of drug doses in the treatment of AIDS

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    MARCO A. L. CAETANO

    2002-09-01

    Full Text Available Numerical optimization techniques are useful in solving problems of computing the best inputs for systems described by mathematical models and when the objectives can be stated in a quantitative form. This work concerns the problem of optimizing the drug doses in the treatment of AIDS in terms of achieving a balance between the therapeutic response and the side effects. A mathematical model describing the dynamics of HIV viruses and CD4 cells is used to compute the short term optimal drug doses in the treatments of patients with AIDS by a direct method of optimization using a cost function of Bolza type. The model parameters were fitted to actual published clinical data. In order to simplify the numerical procedures, the control law is expressed as a series and the sub-optimal control is obtained by truncating the higher terms. When the patient reaches a clinically satisfactory state, the LQR - Linear Quadratic Regulator technique is used to determine the long period maintenance doses for the drugs. The doses computed using the LQR technique tend to be smaller than equivalent constant-dose therapy in terms of increase in the counts of CD4+T cells and reduction of the density of free viruses.Técnicas de otimização numérica são úteis na solução de problemas de determinação da melhor entrada para sistemas descritos por modelos matemáticos e cujos objetivos podem ser expressos de uma maneira quantitativa. Este trabalho aborda o problema de otimizar as dosagens dos medicamentos no tratamento da AIDS em termos de um balanço entre a resposta terapêutica e os efeitos colaterais. Um modelo matemático para descrever a dinâmica do vírus HIV e células CD4 é utilizado para calcular a dosagem ótima do medicamento no tratamento a curto prazo de pacientes com AIDS por um método de otimização direta utilizando uma função custo do tipo Bolza. Os parâmetros do modelo foram ajustados com dados reais obtidos da literatura. Com o objetivo de

  6. The Effectiveness of Life Skills Training on Enhancement of Self-Esteem and Marital Satisfaction among Addicts in Treatment Period

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    R Nooripour

    2014-11-01

    Full Text Available Objective: This study has been done to determine the impact of life skills training on enhancement of self-esteem and marital satisfaction among addicts in treatment period. Method: The research design was semi experimental pretest-posttest with witness group. For each group 12men addicts in treatment period in Qazvin city were selected by available sampling. Rosenberg self-esteem and Enrich marital satisfaction questionnaires were administered among selected samples. Training workshop was conducted on role playing, questioning and answering which was taught by psychology professors in experimental group. Results: Results showed life skills training improved self-esteem and marital satisfaction of addicts in treatment period. Conclusion: Life skills training have a positive impact on self-esteem and marital satisfaction of individuals especially on addicts in treatment period, also life skills training in the field of smoking prevention enhances individuals’ skills (such as self-esteem, marital satisfaction, etc…. Life skills training empower person to actualize his knowledge, attitudes and values, and enable him to have motivation for healthy behavior which this will have significant impact on his relationship with his wife.

  7. Treatment of knee prosthesis infections: evaluation of 15 patients over a 5-year period.

    NARCIS (Netherlands)

    Kosters, K.; Crevel, R. van; Sturm, P.D.J.; Schreurs, B.W.; Waal Malefijt, M.C. de; Kampen, A. van; Kullberg, B.J.

    2009-01-01

    Our objective was to evaluate different treatment alternatives for total knee arthroplasty (TKA) infection and to compare outcomes depending on adherence to a current treatment algorithm. All patients treated for a first episode of TKA infection between January 2000 and July 2005 were included. Pati

  8. State estimation and optimal long period clinical treatment of HIV seropositive patients

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    Juliana M. Grégio

    2009-03-01

    Full Text Available Optimal control theory provides a very interesting quantitative method that can be used to assist the decision making process in several areas of application, such as engineering, biology, economics and sociology. The main idea is to determine the values of the manipulated variables, such as drug doses, so that some cost function is minimized, subject to physical constraints. In this work, the cost function reflects the number of CD4+T cells, viral particles and the drug doses. It is worth noticing that high drug doses are related to more intense side-effects, apart from the impact on the actual cost of the treatment. In a previous paper by the authors, the LQR - Linear Quadratic Regulator approach was proposed for the computation of long period maintenance doses for the drugs, which turns out to be of state feedback form. However, it is not practical to determine all the components of the state vector, due to the fact that infected and uninfected CD4+T cells are not microscopically distinguishable. In order to overcome this difficulty, this work proposes the use of Extended Kalman Filter to estimate the state, even though, because of the nonlinear nature of the involved state equations, the separation principle may not be valid. Extensive simulations were then carried out to investigate numerically if the control strategy consisting of the feedback of estimated states yielded satisfactory clinical results.A teoria de controle ótimo apresenta um método quantitativo muito interessante que pode ajudar no processo de tomada de decisão em algumas áreas de aplicação, tais como engenharia, biologia, economia e sociologia. A principal idéia é determinar os valores das variáveis controladas, tais como doses de medicamentos, onde alguma função-custo é minimizada, sujeito às restrições físicas. Neste trabalho, a função-custo reflete o número de células CD4+T, partículas virais e doses de medicamentos. É fato que altas dosagens de

  9. Undesirable financial effects of head and neck cancer radiotherapy during the initial treatment period

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    Helen Egestad

    2015-01-01

    Full Text Available Background: Healthcare cost and reforms are at the forefront of international debates. One of the current discussion themes in oncology is whether and how patients’ life changes due to costs of cancer care. In Norway, the main part of the treatment costs is supported by general taxpayer revenues. Objectives: The objective of this study was to clarify whether head and neck cancer patients (n=67 in northern Norway experienced financial health-related quality of life (HRQOL deterioration due to costs associated with treatment. Design: HRQOL was examined by the European Organization for Research and Treatment of Cancer (EORTC QLQ-C30 in the beginning and in the end of radiation treatment in patients treated at the University Hospital in Northern Norway. Changes in financial HRQOL were calculated and compared by paired sample T-tests. Multiple regression analyses were used to examine correlations among gender, marital status, age and treatment with or without additional chemotherapy and changes in the HRQOL domain of financial difficulties. Results: The majority of score results at both time points were in the lower range (mean 15–25, indicating limited financial difficulties. We observed no statistically significant differences by gender, marital status and age. Increasing financial difficulties during treatment were reported by male patients and those younger than 65, that is, patients who were younger than retirement age. The largest effect was seen in singles. However, differences were not statistically significant. Conclusions: During the initial phase of the disease trajectory, no significant increase in financial difficulties was found. This is in line with the aims of the Norwegian public healthcare model. However, long-term longitudinal studies should be performed, especially with regard to the trends we observed in single, male and younger patients.

  10. A new treatment for some periodic Schr\\"{o}dinger operators II: the wavefunction

    CERN Document Server

    He, Wei

    2016-01-01

    Following the approach of our previous paper we continue to study the asymptotic solution of periodic Schr\\"{o}dinger operators. Using the eigenvalues obtained earlier the corresponding asymptotic wavefunctions are derived. This gives further evidence in favor of the monodromy relations for the Floquet exponent proposed in the previous paper. In particular, the large energy asymptotic wavefunctions are related to the instanton partition function of N=2 supersymmetric gauge theory with surface operator. A relevant number theoretic dessert is appended.

  11. Spectroscopic characterization of bone tissue of experimental animals after glucocorticoid treatment and recovery period

    Science.gov (United States)

    Mitić, Žarko J.; Najman, Stevo J.; Cakić, Milorad D.; Ajduković, Zorica R.; Ignjatović, Nenad L.; Nikolić, Ružica S.; Nikolić, Goran M.; Stojanović, Sanja T.; Vukelić, Marija Đ.; Trajanović, Miroslav D.

    2014-09-01

    The influence of glucocorticoids on the composition and mineral/organic content of the mandible in tested animals after recovery and healing phase was investigated in this work. The results of FTIR analysis demonstrated that bone tissue composition was changed after glucocorticoid treatment. The increase of calcium, magnesium, phosphorus content and mineral part of bones was statistically significant in recovery phase and in treatment phase that included calcitonin and thymus extract. Some changes also happened in the organic part of the matrix, as indicated by intensity changes for already present IR bands and the appearance of new IR bands in the region 3500-1300 cm-1.

  12. Treatment for retinopathy of prematurity in Denmark in a ten-year period (1996-2005): Is the incidence increasing?

    DEFF Research Database (Denmark)

    Slidsborg, C.; Olesen, H.B.; Jensen, Peter Koch;

    2008-01-01

    contributed to the increased incidence in the latter half of the period. Of the study population, 0.6% were registered as visually impaired because of retinopathy of prematurity within 2 years after birth (early-detected visual impairment). The incidences were not significantly different between 1996 to 2000......OBJECTIVE. The objective of this study was to analyze the population incidence of retinopathy of prematurity treatment in Denmark in the 10-year period from 1996 to 2005. METHODS. Patient charts of infants treated for retinopathy of prematurity and the national birth registry provide information...... about neonatal parameters. These parameters, along with birth in the latter half of the period (2001-2005), were analyzed as risk factors for retinopathy of prematurity. The national registry for blind and visually impaired children was accessed to obtain information about visual impairment attributable...

  13. Comparison of the efficacy of dexmedetomidine and esmolol in the treatment of increased hemodynamic response during the recovery period

    OpenAIRE

    GÜNAY, Hülya; Moğol, Elif Başağan; Kaya, Fatma Nur; Türker, Gürkan; Yavaşcaoğlu, Belgin; Ahun, Filiz; Bebek, Ayşe Neslihan; Yeniaydoğmuş, Tuba

    2012-01-01

    Objectives: Our aim was to compare effectiveness of esmolol and dexmedetomidine in the treatment of increased hemodynamic response during anesthesia recovery period. Materials and methods: 60 ASA I-II patients whom scheduled for elective surgery with endotracheal intubation were randomized before extubation according to their hemodynamic parameters that were increased 20% of their baseline values in order to receive 1mg/kg esmolol (Group Esmolol, n= 30) or 0.5 µg/kg dexmedetomid...

  14. [Clinical and pharmacoeconomic peculiarities of the treatment with cerebrolysin in the period of rehabilitation of is ischemic stroke.].

    Science.gov (United States)

    Gusev, E I; Gekht, A B; Belousov, Iu B; Pavlov, N A; Galanov, D V; Popov, G R; Mil'chakova, L E

    2007-01-01

    The results of the clinical and pharmacoeconomic study of cerebrolysin in the rehabilitative therapy of ischemic stroke presented in the paper revealed the statistically significant regress of neurological disturbances in patients receiving cerebrolysin in daily dosages of 10 and 20 ml as compared to the control group. The rehabilitation of motor functions was more rapid than sensitive ones in patients receiving cerebrolysin comparing to those switched to the basic antihypertensive and antiaggregate therapy. The positive dynamics of speech rehabilitation was observed, the regress of aphatic disturbances being more significant for daily dosage of 20 ml. Rehabilitation rate in the period of treatment with cerebrolysin was higher for daily dosage of 20 ml than that of 10 ml. A prolonged effect of the drug during the long period after its withdrawal was found that resulted in higher rates of rehabilitation to the 11th week in patients receiving cerebrolysin as compared to the control group. Average total cost of direct medical expenses per a patient estimated in the pharmacoeconomic analysis for the groups receiving cerebrolysin and the control group was higher in the former groups, in particular in that with 20 ml dosage of cerebrolysin. A cost-efficacy analysis revealed that the cost of cerebrolysin treatment per effective unit (a cost of one score on the Lindmark scale and the Barthel scale) was less or comparable in patients receiving cerebrolysin comparing to the control group. The study suggests clinical and pharmacoeconomic expediency of cerebrolysin treatment in rehabilitative period of ischemic stroke.

  15. Clitoria ternatea (Linn) root extract treatment during growth spurt period enhances learning and memory in rats.

    Science.gov (United States)

    Rai, K S; Murthy, K D; Karanth, K S; Rao, M S

    2001-07-01

    Neonatal rat pups (7 days old) were intubated with either 50 mg/kg body weight or 100 mg/kg body weight of aqueous root extract of Clitoria ternatea (CTR) for 30 days. These rats were then subjected to open field, two compartment passive avoidance and spatial learning (T-Maze) tests (i) immediately after the treatment and (ii) 30 days after the treatment, along with age matched normal and saline control rats. Results showed no change in open field behaviour, but showed improved retention and spatial learning performance at both time points of behavioural tests, indicating the memory enhancing property of CTR which implicates a permanent change in the brain of CTR treated rats. PMID:11881569

  16. Vojta and Bobath combined treatment for high risk infants with brain damage at early period

    Institute of Scientific and Technical Information of China (English)

    Chunyan Wu; Xiaohui Peng; Xuesong Li; Qingling Niu; Hong Guo; Huitao Huang

    2007-01-01

    BACKGROUND: In the process of early screening and interventions to high risk infants with brain damage,the occasion and choosing methods of interventions and the combined application of different interventions are still at the exploratory phase.OBJECTIVE: To observe the efficacy of early intervention using Vojta and Bobath combined treatment in high risk infants with brain damage, and investigate the effect of early rehabilitation on the prognosis.DESIGN: A randomized controlled comparative observation.SETTING: Daqing Oil Field General Hospital of Heilongjiang Province.PARTICIPANTS: Eighty-four high risk infants younger than 1 year were selected from the Department of Pediatrics, Daqing Oil Field General Hospital of Heilongjiang Province from October 2005 to October 2006,including 52 boys (62%) and 32 girls (38%). The treatment started at the age of 0 - 3 months in 11 cases (13%), 4 - 6 months in 28 cases (33%), 7 - 9 months in 35 cases (42%), and 10 - 12 months in 10 cases (12%). Infants with at least two of the followings were enrolled, including 7 Vojta abnormal postural reflexes,slow or disorder of motor development, increase of muscular tension, postural abnormality, primary reflection residual and CT/MRI abnormalities. Informed consents were obtained from their guardians. The 84 infants were randomly divided into treatment group (n =42) and control group (n =42).METHODS: All the children were intravenously injected with cerebroprotein hydrolysate injection or cattle encephalon glycoside and ignotin injection, 10 times as a course for 2 - 5 courses; Besides, the infants in the treatment group also received early rehabilitative training of Vojta and Bobath combined treatment, once a day, 40 minutes per time, 5 times a week followed by a 2-day rest, 1 month as a course, and totally 2 - 5 courses. The Vojta method was to facilitate the automatic regulation by reflexlocomotion. Bobath method was to inhibit abnormal posture but facilitate the normal one, thus it is

  17. Open-Label, Long-Term Safety Study of Cevimeline in the Treatment of Postirradiation Xerostomia

    International Nuclear Information System (INIS)

    Purpose: To assess the safety of long-term cevimeline treatment of radiation-induced xerostomia in patients with head-and-neck cancer; and to assess the efficacy of cevimeline in these patients. Methods and Materials: A total of 255 adults with head-and-neck cancer who had received more than 40 Gy of radiation 4 months or more before entry and had clinically significant salivary gland dysfunction received cevimeline hydrochloride 45 mg t.i.d. orally for 52 weeks. Adverse events (AEs), their severity, and their relationship to the study medication were assessed by each investigator. The efficacy assessment was based on subjects' global evaluation of oral dryness on a scale of 0 (none) to 3 (severe). Results: Overall, 175 subjects (68.6%) experienced expected treatment-related AEs, most mild to moderate. The most frequent was increased sweating (47.5%), followed by dyspepsia (9.4%), nausea (8.2%), and diarrhea (6.3%). Fifteen subjects (5.9%) experienced Grade 3 treatment-related AEs, of which the most frequent was increased sweating. Eighteen subjects (7.1%) reported at least one serious AE, and 45 subjects (17.6%) discontinued study medication because of an AE. The global efficacy evaluation at the last study visit showed that cevimeline improved dry mouth in most subjects (59.2%). Significant improvement was seen at each study visit in the mean change from baseline of the numeric global evaluation score (p < 0.0001). Conclusions: Cevimeline 45 mg t.i.d. was generally well tolerated over a period of 52 weeks in subjects with xerostomia secondary to radiotherapy for cancer in the head-and-neck region

  18. A Case Report on Juvenile Neuromyelitis Optica: Early Onset, Long Remission Period, and Atypical Treatment Response.

    Science.gov (United States)

    Elpers, Christiane; Gross, Catharina C; Fiedler, Barbara; Meuth, Sven G; Kurlemann, Gerhard

    2015-08-01

    Neuromyelitis optica (NMO) is a severe inflammatory demyelinating disease of the central nervous system and preferentially targets the optic nerves and spinal cord. NMO is rare in children and clinical course of the disease is highly variable as described in studies. Here, we present a case report of a young girl presenting with a rare course of pediatric NMO with an early disease onset at the age of 12 years, a relapse free interval of 4 years, evidence of NMO immunoglobulin G (IgG) and an unusual response against immunosuppressive therapy. The aim of this report is to highlight the potentially long remission period between relapses complicating proper diagnosis despite well defined diagnostic criteria. In addition, we want to encourage the use of rituximab in pediatric NMO, although larger cohorts are warranted to establish B cell depleting therapies in juvenile NMO.

  19. Dark Period Following UV-C Treatment Enhances Killing of Botrytis cinerea Conidia and Controls Gray Mold of Strawberries.

    Science.gov (United States)

    Janisiewicz, Wojciech J; Takeda, Fumiomi; Glenn, D Michael; Camp, Mary J; Jurick, Wayne M

    2016-04-01

    Strawberries are available throughout the year either from production in the field or from high and low tunnel culture. Diversity of production conditions results in new challenges in controlling diseases before and after harvest. Fungicides have traditionally been used to control these diseases; however, their limitations necessitate a search for new approaches. We found that UV-C irradiation of Botrytis cinerea, a major pathogen of strawberry, can effectively kill this fungus if a dark period follows the treatment. The inclusion of a 4-h dark period resulted in almost complete kill of B. cinerea conidia on agar media at a dose of 12.36 J/m2. The UV-C dose did not cause a reduction in photosynthesis in strawberry leaves or discoloration of sepals, even after exposing plants repeatedly (twice a week) for 7 weeks. Although irradiation of dry conidia of B. cinerea with this dose resulted in some survival, the conidia were not infective and not able to cause decay even when inoculated onto a highly susceptible mature apple fruit. Irradiation of strawberry pollen at 12.36 J/m2 did not affect pollen germination, tube growth and length in vitro, or germination and tube growth in the style of hand-pollinated emasculated strawberry flowers. No negative effect of the UV-C treatment was observed on fruit yield and quality in high tunnel culture. In the fruit and flower petal inoculation tests, the UV-C treatment was highly effective in reducing fruit decay and petal infection. This UV-C treatment with an exposure time of 60 s may be useful in controlling gray mold in tunnel production of strawberries and may also have the potential for use in intensive field and indoor production of other fruits and vegetables providing that a 4-h dark period follows the irradiation. PMID:26714103

  20. Performance of wetland systems in the treatment of sewage generated at an educational institution, after a recession period

    Directory of Open Access Journals (Sweden)

    Paulo Fortes Neto

    2011-12-01

    Full Text Available Education institutions are potential generators of large volumes of domestic sewage. Studies of natural systems for effluent treatment have shown good efficiency and low cost compared to traditional systems. This makes them suitable for various segments of society, including educational institutions. A characteristic shared by most educational institutions is that they have the same academic calendars that include a long period of recess when, in many cases, the flow of sewage systems drops to almost zero, causing damage to both macrophytes in sewage bed and their associated microorganisms. This study aimed to evaluate the efficiency of a wetland system in an educational institution, after the recess period. It was observed for 45 days if there were signs of natural recovery, without any intervention. After this period, 15 seedlings of Thypha sp. were planted in the sewage bed, and analyses were performed for 45 additional days. The system efficiency in reducing turbidity, NH3, NO3- and phosphorus was, respectively, 63.0%, 21.7%, 31.1% and 20.3%, and for BOD, COD and thermotolerant coliforms, the average efficiency was 46.0%, 29.7% and 44.0%, respectively. If considered only the period after planting the results improved, with the following results: turbidity = 78.2%, 38.0% = NH3, NO3- = 53.2% = 25.6% phosphorus, BOD = 66, 2% = 36.5% COD and thermotolerant coliform = 60.7%. The results demonstrated the importance of vegetation bed for the efficiency of such treatment system.

  1. Fall in incidence of guinea-worm infection in western Nigeria after periodic treatment of infected persons

    OpenAIRE

    Kale, O. O.

    1982-01-01

    Between 1971 and 1974 a series of drug trials was conducted in 17 rural communities in western Nigeria where guinea-worm is endemic. During these trials and in subsequent years treatment, in the form of chemotherapy and/or dressing of ulcers, was given to all infected persons. A longitudinal study of infection in these villages showed a marked fall in the annual incidence over an 8-year period. The aggregate reduction in incidence in the three sectors surveyed was from 15.5% to 0.5% in sector...

  2. [Experience of systematization on the treatment of patients with upper jaws fractures, during the period 1991-2000].

    Science.gov (United States)

    Khinkov, D

    2005-01-01

    A retrospecive analysis was done of the 128 patients with fractures in a upper jaw, treated during the period 1991-2000. The treatment of the patients with partial fractures in a alveolar part of maxilla and frontal wall of maxillary sinus, consist of debridement on the open wound, primery stiched and stabilization by arch bar of perspective teeth. In the cases with fractures of tuber maxilla and opening of maxillary sinus they tray to clouse it by Rhermann technique, with or without radical antrothomy by Caldwell-Luc technique. On the patients by total upper jaw fractures they try lead by princip of duble stage fixation: from one side-of intact upper bone structures and the other side-on a mandible. On the cases of upper jaw fractures, combine with barain traums. was treated conservativly - the specialize treatment of facial injures was postpoun until stabilization of brain status.

  3. [Complex pathogenetic treatment schemes of vascular dyscirculatory disorders in the remote period after exposure to low dose radiation].

    Science.gov (United States)

    2013-01-01

    Complex studies including modern methods of investigation of structures and functions of nervous system: electroencephalograsphy (EEG), coherent analysis, neuropsychological study and methods of neuroimaging were performed in 517 participants in liquidation of consequences of the accident (LCA) at the Chernobyl NPP in 1986-1987. Dyscirculatory metabolic encephalopathy was revealed to be the main pathology with the etiological mechanism based on dyscirculatorhypoxic and metabolic disorders. Complexity of the revealed symptoms testified to an early organism aging in remote periods after exposure to low dose radiation. Pathogenetic schemes were developed for treatment of dyscirculatory encephalopathy in liquidators, which include drugs improving blood supply, antiaggregants, antioxidants and metabolites of the brains in various combinations. Taking into consideration that early appearance of vascular dyscirculatory disorders observed in liquidators is the sign of early aging of the organism, geroprotectors were added to treatment schemes. PMID:25507773

  4. The optimal period of Ca-EDTA treatment for parthenogenetic activation of porcine oocytes during maturation culture

    Science.gov (United States)

    MORITA, Yasuhiro; TANIGUCHI, Masayasu; TANIHARA, Fuminori; ITO, Aya; NAMULA, Zhao; DO, Lanh Thi Kim; TAKAGI, Mitsuhiro; TAKEMOTO, Tatsuya; OTOI, Takeshige

    2016-01-01

    The changes triggered by sperm-induced activation of oocytes, which are required for normal oocyte development, can be mediated by other agents, thereby inducing the parthenogenesis. In this study, we exposed porcine oocytes to 1 mM Ca-EDTA, a metal-ion chelator, at various intervals during 48 hr of in vitro maturation to determine the optimum period of Ca-EDTA treatment for parthenogenetic activation. When the oocytes were cultured with or without Ca-EDTA from 36 hr (post-12), 24 hr (post-24), 12 hr (post-36) and 0 hr (post-48) after the start of maturation culture, the blastocyst formation rates were significantly higher (P<0.05) in the post-24, post-36 and post-48 groups (3.3%, 4.0% and 2.6%, respectively) than those in the control group without treatment (0%). Furthermore, when the oocytes were cultured with Ca-EDTA for 0 hr (control), 12 hr (pre-12), 24 hr (pre-24), 36 hr (pre-36) and 48 hr (pre-48) from the start of maturation culture, the oocytes formed blastocysts only in the pre-36 and pre-48 groups (0.4% or 0.8%, respectively). Pronuclei (<66.7%) were observed only when the periods of Ca-EDTA treatment were more than 12 hr during maturation culture. In the control group, no pronuclei were detected. Our findings demonstrate that porcine immature oocytes can be parthenogenetically activated by Ca-EDTA treatment for at least 24 hr to 36 hr during maturation culture, leading to pronucleus formation followed by the formation of blastocysts. PMID:26947170

  5. Impact of periodic health examination on surgical treatment for uterine fibroids in Beijing: a case-control study

    Directory of Open Access Journals (Sweden)

    Yang Ling-Ling

    2010-12-01

    Full Text Available Abstract Background During the past 2 decades, there has been a rapid proliferation of "health examination center (HEC" across China. The effects of their services on public's health have not been systemically investigated. This study aimed to assess the impact of periodic health examination (PHE at HEC on surgical treatment for uterine fibroids in Beijing residents. Methods We identified 224 patients with a primary diagnosis of uterine fibroids who had surgical treatment at four Level-1 general hospitals in Beijing, from June 1, 2009 to October 20, 2009. Controls were women who did not have surgery for uterine fibroids, matched (1:1 ratio for age (within 2 years. A standard questionnaire was used to inquire about whether participants had PHE at HEC during the previous 2 years. Results PHE at HEC within 2 years were associated with surgical treatment for uterine fibroids. Odds ratios was 4.05 (95% CI, 2.61-6.29 P Conclusions Our study showed PHE currently provided at HEC in China were associated with significantly increased use of surgical treatment for uterine fibroids in women. Further studies are needed to assess the effects of PHE on clinical as well as on broad societal outcomes in Chinese in contemporary medical settings.

  6. Apomorphine Penject – Emerging Evidence and Treatment Strategies for Delayed on and off Periods in Parkinson’s disease

    Directory of Open Access Journals (Sweden)

    Olivier Rascol

    2014-07-01

    Full Text Available This educational symposium was held during the Joint Congress of European Neurology (EFNS–ENS, which took place from 31st May to 3rd June 2014 in Istanbul, Turkey, and was sponsored by Britannia Pharmaceuticals Limited. The symposium debated the problem of delayed ON and OFF periods in Parkinson’s disease that can occur even in patients optimised on oral medication. Emerging evidence for the rapid and effective resolution of such complications using apomorphine intermittent injection (penject was reviewed with particular reference to the positive results of the recent AM IMPAKT trial in patients with morning akinaesia. The discussions were illustrated with examples of ‘real life’ patient case studies to help determine which patients might be best suited for treatment with apomorphine injection.

  7. Comparison of the efficacy of dexmedetomidine and esmolol in the treatment of increased hemodynamic response during the recovery period

    Directory of Open Access Journals (Sweden)

    Ayşe Neslihan Bebek

    2012-03-01

    Full Text Available Objectives: Our aim was to compare effectiveness of esmololand dexmedetomidine in the treatment of increasedhemodynamic response during anesthesia recovery period.Materials and methods: 60 ASA I-II patients whomscheduled for elective surgery with endotracheal intubationwere randomized before extubation according to theirhemodynamic parameters that were increased 20% oftheir baseline values in order to receive 1mg/kg esmolol(Group Esmolol, n= 30 or 0.5 μg/kg dexmedetomidine(Group Dexmedetomidine, n= 30. Heart rate (HR, systolicand diastolic blood pressures (SBP,DBP, peripheral oxygensaturation (SpO2, end tidal carbon dioxide (ETCO2values, extubation time, recovery time were recorded. Theduration till having pain requiring analgesic was recordedand cognitive functions were evaluated with short memoryorientation concentration test at 20th and 50th minutes.Results: After drug, HR reductions were significant at allperiods in group Dexmedetomidine (Z2-Z10: p<0.001,Z11:p=0.001, Z12, p=0.006. In group DexmedetomidineSBP value was high at 3rd min after drug (p<0.001, andSBP values were lower in all periods before and after extubation(Z6- Z10: p<0.001, Z11: p=0.02, Z12: p=0.04.In group Dexmedetomidine DBP value was higher at 1stmin after drug (p=0.001, DBP values were lower at 10thmin after drug and before extubation (p= 0.045, p=0.001.The duration of pain requiring analgesic and recoveryperiod were longer in dexmedetomidine group (p<0.001,p<0.001.Conclusions: Although esmolol and dexmedetotimidineattenuated hemodynamic response during recovery period,dexmedetotimidine was more effective in hemodynamicstabilization and the duration of pain requiring analgesicwas longer. Esmolol provided faster recovery time. JClin Exp Invest 2012; 3(1: 53-60

  8. Planetary populations in the mass-period diagram: A statistical treatment of exoplanet formation and the role of planet traps

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Yasuhiro [Currently EACOA Fellow at Institute of Astronomy and Astrophysics, Academia Sinica (ASIAA), Taipei 10641, Taiwan. (China); Pudritz, Ralph E., E-mail: yasu@asiaa.sinica.edu.tw, E-mail: pudritz@physics.mcmaster.ca [Also at Origins Institute, McMaster University, Hamilton, ON L8S 4M1, Canada. (Canada)

    2013-11-20

    The rapid growth of observed exoplanets has revealed the existence of several distinct planetary populations in the mass-period diagram. Two of the most surprising are (1) the concentration of gas giants around 1 AU and (2) the accumulation of a large number of low-mass planets with tight orbits, also known as super-Earths and hot Neptunes. We have recently shown that protoplanetary disks have multiple planet traps that are characterized by orbital radii in the disks and halt rapid type I planetary migration. By coupling planet traps with the standard core accretion scenario, we showed that one can account for the positions of planets in the mass-period diagram. In this paper, we demonstrate quantitatively that most gas giants formed at planet traps tend to end up around 1 AU, with most of these being contributed by dead zones and ice lines. We also show that a large fraction of super-Earths and hot Neptunes are formed as 'failed' cores of gas giants—this population being constituted by comparable contributions from dead zone and heat transition traps. Our results are based on the evolution of forming planets in an ensemble of disks where we vary only the lifetimes of disks and their mass accretion rates onto the host star. We show that a statistical treatment of the evolution of a large population of planetary cores caught in planet traps accounts for the existence of three distinct exoplanetary populations—the hot Jupiters, the more massive planets around r = 1 AU, and the short-period super-Earths and hot Neptunes. There are very few populations that feed into the large orbital radii characteristic of the imaged Jovian planet, which agrees with recent surveys. Finally, we find that low-mass planets in tight orbits become the dominant planetary population for low-mass stars (M {sub *} ≤ 0.7 M {sub ☉}).

  9. CRYOGENIC TREATMENT FOR CANCER OF THE TONGUE AND ORAL CAVITY (ANALYSIS OF ITS EFFICIENCY ACCORDING TO SURVIVAL RATES IN THE PERIOD 1975–2009)

    OpenAIRE

    T. D. Tabolinovskaya

    2013-01-01

    Case histories of 366 patients with cancer of the oral mucosa, tongue, and oropharynx who had received cryogenic treatment at the N.N. Blokhin Russian Cancer Research Center in the period 1975 to 2009 served as the material for the investigation. Analysis of the longterm results of cryogenic treatment for primary and recurrent cancers and tumors untreated after traditional treatments showed the efficiency of this method in 75.8 and 48.2 % of primary and recurrent cancer patients, respectively...

  10. Secular, Spiritual and religious Existential concerns during final diagnostics and treatment period – The lived experiences of women undergoing ovarian cancer surgery

    DEFF Research Database (Denmark)

    Hounsgaard, Lise; Seibæk, L.; Hvidt, N. C.

    2013-01-01

    a woman with ovarian cancer during her first treatment period. Although the women experienced their health to be seriously threatened, they also felt hope, will, and courage. The diagnostic procedures and treatment had comprehensive impact on their lives. However, hope and spirituality were important......Introduction. This paper deals with secular, spiritual, and religious existential concerns during severe illness. Materials and Methods. Qualitative research interviews were made before and after surgery with women who underwent final diagnostics, surgery, and chemotherapy for ovarian cancer...

  11. Surgical treatment of partial atrioventricular septal defect: functional analysis of the mitral valve in the postoperative period

    Directory of Open Access Journals (Sweden)

    Josué Viana Castro Neto

    2002-11-01

    Full Text Available OBJECTIVE: To study mitral valve function in the postoperative period after correction of the partial form of atrioventricular septal defect. METHODS: Fifty patients underwent surgical correction of the partial form of atrioventricular septal defect. Their mean age was 11.8 years and 62% of the patients were males. Preoperative echocardiography showed moderate and severe mitral insufficiency in 44% of the patients. The mitral valve cleft was sutured in 45 (90% patients (group II - GII. Echocardiographies were performed in the early postoperative period, and 6 and 12 months after hospital discharge. RESULTS: The patients who had some type of arrhythmia in the postoperative period had ostium primum atrial septal defect of a larger size (2.74 x 2.08 cm. All 5 patients in group I (GI, who did not undergo closure of the cleft, had a competent mitral valve or mild mitral insufficiency in the preoperative period. One of these patients began to have moderate mitral insufficiency in the postoperative period. On the other hand, in GII, 88.8% and 82.2% of the patients had competent mitral valve or mild mitral insufficiency in the early and late postoperative periods, respectively. CONCLUSION: The mitral valve cleft was repaired in 90% of cases. Echocardiography revealed competent mitral valve or mild mitral insufficiency in 88.8% and 82.2% of GII patients in the early and late postoperative periods, respectively.

  12. Short-day treatment during the growing period limits shoot growth and increases frost hardiness of hybrid aspen plants in the nursery

    Institute of Scientific and Technical Information of China (English)

    Zhang Gang; Jaana Luoranen; Heikki Smolander

    2007-01-01

    In Finland, under nursery conditions hybrid aspen may continue their shoot growth until early September. Thus,frost hardening is usually delayed. To solve this problem, We used a three-week period of short-day (SD) treatment between late July and mid-August. During autumn after frost exposure,frost hardiness (FH) Was assessed three times with a stem-browning test. The resuits showed that after SD treatment shoot growth ceased and FH increased when compared to untreated hybrid aspen. Furthermore,the height of SD-treated hybrid aspen varied much less than that of the control plants. We conclude that SD treatment in the nursery during the growing period can be used as a supplementary method for producing well-hardened and uniform hybrid aspen plants.

  13. 经行风疹的中药周期性治疗%Periodical treatment of Chinese herbs for menstrual rubella

    Institute of Scientific and Technical Information of China (English)

    李凌

    2012-01-01

    The mechanism of menstrual rubella formed to be different shapes, characterized by itchy welts and attacked patient recurrently, they frequently came before menstruation and through the menstrual period. The mechanism of menstrual rubella in Chinese theory is heat accumulated in Yangming meridian and fur offended by wind-heat. The treatment for menstrual rubella is periodical treatment according to menstrual cycle. The basic principal is abreacting wind, nourishing Wood and eliminating heat in the premenstrual period, driving wind and removing heat in the menstrual period, nourishing blood and calming wind after menstruation. After the treatment, the chronic urticaria was cured and never attacked the patients before or during menstruation days any more.%经行风疹块,每值临经或行经期间,全身皮肤突起疹块,疹形大小不一,瘙痒异常,甚则融合成片,经净渐退,常反复发作,迁延不愈.若经行风疹为阳明积热于内,风热外侵皮毛;治疗可按月经周期性治疗,经前疏风养血,清热除湿;经期祛风清热;经后主要予以养血熄风治疗为基本治疗原则.

  14. High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period

    Directory of Open Access Journals (Sweden)

    W. Louis Cleveland

    2009-01-01

    Full Text Available This paper describes an individual who was diagnosed with obsessive-compulsive disorder (OCD and body dysmorphic disorder (BDD at age 17 when education was discontinued. By age 19, he was housebound without social contacts except for parents. Adequate trials of three selective serotonin reuptake inhibitors, two with atypical neuroleptics, were ineffective. Major exacerbations following ear infections involving Group A -hemolytic streptococcus at ages 19 and 20 led to intravenous immune globulin therapy, which was also ineffective. At age 22, another severe exacerbation followed antibiotic treatment for H. pylori. This led to a hypothesis that postulates deficient signal transduction by the N-methyl-D-aspartate receptor (NMDAR. Treatment with glycine, an NMDAR coagonist, over 5 years led to robust reduction of OCD/BDD signs and symptoms except for partial relapses during treatment cessation. Education and social life were resumed and evidence suggests improved cognition. Our findings motivate further study of glycine treatment of OCD and BDD.

  15. Effect of rehabilitation treatment during different period on recovery of patients with spinal cord injury%脊髓损伤患者不同时期介入康复治疗的效果观察

    Institute of Scientific and Technical Information of China (English)

    马春山; 秦四遥

    2001-01-01

    Objective To investigate efficacy of rehabilitation treatment for patients with spinal cord injury(SCI) during different period.Methods 108 patients received rehabiltiation treatment during different period after SCI.Comparision study was performed retrospectively.Results ADL of patients recepting rehabilitation treatment 3 months after SCI was increased significantly.Conclusion Early rehabilitation interventions significantly accelerate functional recovery of patients with SCI.

  16. Beneficial effects of a neurotrophic peptidergic mixture persist for a prolonged period following treatment interruption in a transgenic model of Alzheimer's disease.

    Science.gov (United States)

    Rockenstein, Edward; Ubhi, Kiren; Pham, Emiley; Michael, Sarah; Doppler, Edith; Novak, Philipp; Inglis, Chandra; Mante, Michael; Adame, Anthony; Alvarez, X Anton; Moessler, Herbert; Masliah, Eliezer

    2011-11-01

    Neurodegenerative disorders such as Alzheimer's disease (AD) are characterized by the loss of neurotrophic factors, and experimental therapeutical approaches to AD have investigated the efficacy of replacing or augmenting neurotrophic factor activity. Cerebrolysin, a peptide mixture with neurotrophic-like effects, has been shown to improve cognition in patients with AD and to reduce synaptic and behavioral deficits in transgenic (tg) mice overexpressing the amyloid precursor protein (APP). However, it is unclear how long-lasting the beneficial effects of Cerebrolysin are and whether or not behavioral and neuropathological alterations will reappear following treatment interruption. The objective of the present study was to investigate the consequences of interrupting Cerebrolysin treatment (washout effect) 3 and 6 months after the completion of a 3-month treatment period in APP tg mice. We demonstrate that, in APP tg mice, Cerebrolysin-induced amelioration of memory deficits in the water maze and reduction of neurodegenerative pathology persist for 3 months after treatment interruption; however, these effects dissipate 6 months following treatment termination. Immunohistochemical analysis demonstrated that the decrease in neocortical and hippocampal amyloid plaque load observed in Cerebrolysin-treated APP tg mice immediately after treatment was no longer apparent at 3 months after treatment interruption, indicating that the beneficial effects of Cerebrolysin at this time point were independent of its effect on amyloid-β deposition. In conclusion, the results demonstrate that the effects of Cerebrolysin persist for a significant period of time following treatment termination and suggest that this prolonged effect may involve the neurotrophic factor-like activity of Cerebrolysin. PMID:21793038

  17. 围生期出血的治疗和护理%Treatment and care of hemorrhage in the prenatal period

    Institute of Scientific and Technical Information of China (English)

    逯朝霞; 刘宽荣

    2014-01-01

    目的:探讨围生期出血的治疗和护理方法。方法回顾性分析2009年1月-2011年12月我院38例围生期出血患者的临床资料、治疗结果和护理方法。结果38例患者中急症子宫切除术3例,清宫术26例,剖宫产4例,助产分娩5例,6例输注血液制品。均痊愈出院。结论对孕产妇进行围生期全程心理干预和护理,能减少围生期出血的危险。%ObjectiveConclusion the treatment of hemorrhage in the perinatal period and nursing methods. MethodsOn between January 2009 and December 2009,the clinical data of 38 cases of hemorrhage in the perinatal period,the treatment and nursing methods were analyzed.ResultsEmergency hysterectomy 3 cases,26 cases of cesarean section 4 cases,the birth of midwifery in 5 cases. Infusion of 6 cases of blood products. Hospital were recovered.ConclusionTo the entire psychological intervention in the perinatal period and maternal care,can reduce the risk of hemorrhage in the perinatal period.

  18. Ultrasound surgery with a toric transducer allows the treatment of large volumes over short periods of time

    Science.gov (United States)

    Melodelima, David; N'Djin, William A.; Parmentier, Hubert; Chesnais, Sabrina; Rivoire, Michel; Chapelon, Jean-Yves

    2007-11-01

    Thermal ablation by physical agents is widely used in clinical settings, but it generally results in a small coagulated volume. Here, we report that a technologically advanced high intensity focused ultrasound transducer can significantly enlarge the coagulated volume over short periods of time. Eight ultrasound emitters were created by sectioning a single toric piezocomposite transducer. A single thermal lesion is created when the eight emitters perform alternative and consecutive 5s ultrasound exposures. This paper presents in vivo evidence that the coagulated volume obtained from a 40s total exposure in the liver was 8.6±4.8cm3.

  19. Treatment of relapsed acute myelocytic leukemia with a combination of aclarubicin and cytosine arabinoside.

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    Takahashi,Isao

    1982-02-01

    Full Text Available Relapses in nine patients with acute myelocytic leukemia were treated with a combination of aclarubicin (ACR and cytosine arabinoside (ara-C. ACR, 40 mg/m2/day, was administered daily by intravenous injection from day 1 to day 3 and ara-C, 60-80 mg/m2/day, divided into 2 doses, was given every 12 h by intravenous infusion from day 1 to day 7. Depending on the state of the bone marrow, ACR-ara-C regimen was modified in administration period and repeated after the resting periods of at least 7 days. Complete remission was obtained in 7 of 9 patients (77.8%. The time required for achieving the complete remission varied from 20 to 55 days with a median of 39 days. The duration of complete remission was from 8 to 52 weeks with a median of 22 weeks. Side effects on digestive system such as nausea, vomiting and anorexia, were seen in all patients, although they were managed by symptomatic treatment. The results indicate the effectiveness of this ACR-ara-C regimen in the clinical management of acute nonlymphocytic leukemia.

  20. Comparative evaluation of course and treatment of climacteric period in women living in radionuclide-contaminated territories

    International Nuclear Information System (INIS)

    The appearance of heavy forms of climacteric syndrome in territories with density of radioactive contamination up to 15 Ci/km2 is higher than in those living in territories with the level of contamination from 1 to 5 Ci/km2. At treatment of climacteric syndrome during menopause in women living in radionuclide-contaminated territory, preparations containing natural estrogen and gestagens are of higher priority. (Authors)

  1. Early exposure of infants to GI nematodes induces Th2 dominant immune responses which are unaffected by periodic anthelminthic treatment.

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    Victoria J Wright

    Full Text Available We have previously shown a reduction in anaemia and wasting malnutrition in infants <3 years old in Pemba Island, Zanzibar, following repeated anthelminthic treatment for the endemic gastrointestinal (GI nematodes Ascaris lumbricoides, hookworm and Trichuris trichiura. In view of the low intensity of worm infections in this age group, this was unexpected, and it was proposed that immune responses to the worms rather than their direct effects may play a significant role in morbidity in infants and that anthelminthic treatment may alleviate such effects. Therefore, the primary aims of this study were to characterise the immune response to initial/early GI nematode infections in infants and the effects of anthelminthic treatment on such immune responses. The frequency and levels of Th1/Th2 cytokines (IL-5, IL-13, IFN-gamma and IL-10 induced by the worms were evaluated in 666 infants aged 6-24 months using the Whole Blood Assay. Ascaris and hookworm antigens induced predominantly Th2 cytokine responses, and levels of IL-5 and IL-13 were significantly correlated. The frequencies and levels of responses were higher for both Ascaris positive and hookworm positive infants compared with worm negative individuals, but very few infants made Trichuris-specific cytokine responses. Infants treated every 3 months with mebendazole showed a significantly lower prevalence of infection compared with placebo-treated controls at one year following baseline. At follow-up, cytokine responses to Ascaris and hookworm antigens, which remained Th2 biased, were increased compared with baseline but were not significantly affected by treatment. However, blood eosinophil levels, which were elevated in worm-infected children, were significantly lower in treated children. Thus the effect of deworming in this age group on anaemia and wasting malnutrition, which were replicated in this study, could not be explained by modification of cytokine responses but may be related to

  2. Homeopathic treatment of elderly patients - a prospective observational study with follow-up over a two year period

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    Willich Stefan N

    2010-02-01

    Full Text Available Abstract Background Very little is known about the range of diagnoses, course of treatment and long-term outcome in elderly patients who choose to receive homeopathic medical treatment. We investigated homeopathic practice in an industrialised country under everyday conditions. The aim of the study was to determine the spectrum of diagnoses and treatments, as well as to describe the course of illness over time among older patients who chose to receive homeopathic treatment. Methods In this subgroup analysis of a prospective, multicentre cohort study totally including 3981 patients treated by homeopathic physicians in primary care practices in Germany and Switzerland, data was analysed from all patients > 70 years consulting the physician for the first time. The main outcome measures were: assessment by patient of the severity of complaints (numeric rating scales and quality of life (SF-36 and by the physician of the severity of diagnoses (numeric rating scales at baseline, and after 3, 12, and 24 months. Results A total of 83 patients were included in the subgroup analysis (41% men, mean age 73.2 ± (SD 3.1 years; 59% women, 74.3 ± 3.8 years. 98.6 percent of all diagnoses were chronic with an average duration of 11.5 ± 11.5 years. 82 percent of the patients were taking medication at baseline. The most frequent diagnoses were hypertension (20.5%, 11.1 ± 7.5 years and sleep disturbances (15.7%, 22.1 ± 25.8 years. The severity of complaints decreased significantly between baseline and 24 months in both patients (from 6.3 (95%CI: 5.7-6.8 to 4.6 (4.0-5.1, p Conclusion The severity of disease showed marked and sustained improvements under homeopathic treatment, but this did not lead to an improvement of quality of life. Our findings might indicate that homeopathic medical therapy may play a beneficial role in the long-term care of older adults with chronic diseases and studies on comparative effectiveness are needed to evaluate this hypothesis.

  3. Time trends of cannabis use among treatment-seeking individuals at government de-addiction centers across India over a period of 7 years

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    Yatan Pal Singh Balhara

    2016-01-01

    Full Text Available Background: Cannabis continues to be the most commonly used illicit psychoactive substance globally. The National Survey in India conducted in the year 2004 also reported it to be the most commonly used illicit substance in the country. Furthermore, it was reported to be the second most commonly used psychoactive substance by the treatment seekers at de-addiction centers in the country. Objectives: To assess time trends of cannabis use among treatment-seeking individuals at government de-addiction centers across India over a period of 7 years. Materials and Methods: The study utilized data collected through Drug Abuse Monitoring System across India. The data of treatment seekers from de-addiction centers established under the Drug De-addiction Program, Ministry of Health and Family Welfare, Government of India and supported by the Ministry of Social Justice and Empowerment, Government of India (122 in number across the country were analyzed. Results: A total of 107,469 individuals sought treatment from government de-addiction centers over the 7 years (2007–2013 period. With the exception of an aberration for the year 2012, there has been a steady decline in the proportion of treatment seekers who are not current cannabis users. A significantly greater proportion (Chi-square: 586.30, df: 1, P < 0.001 of individuals with current cannabis use alone or along with tobacco (20.4% tend to have a co-morbid psychiatric disorder as compared to treatment seekers with current use of substances other than cannabis (6.1%. Conclusions: It is important to focus on cannabis in clinical service delivery and research in the country.

  4. Mechanism of increasing the thermal effect zone thickness in pulse periodic treatment of a target by an electron beam

    International Nuclear Information System (INIS)

    The factors determining the layer thickness growth in the thermal effect zone of a target, made of steel 45, in pulse periodic impact by low-energy high-current electron beam in the mode of initial melting are analyzed on the basis of numerical modeling of temperature fields. Conclusion is made that thickness growth is conditioned by scattering of the energy pulse density from pulse to pulse and by the availability of individual pulses with increase in the energy value. It is shown that change of steel thermophysical properties occurring by irradiation on the account of saturation of target near-surface area by carbon leads to thickness growth only of those layers of thermal effect zone which are formed in the former melt area. The target temperature dependence on the irradiated pulse number is measured and numerically calculated

  5. Consistent treatment of charged systems within periodic boundary conditions: The Projector Augmented-Wave and pseudopotential methods revisited

    Science.gov (United States)

    Crocombette, Jean-Paul; Bruneval, Fabien; Gonze, Xavier; Dorado, Boris; Torrent, Marc; Jollet, Francois

    2014-03-01

    The ab initio calculation of charged defect properties in solids is not straightforward because of the delicate interplay between the long-range Coulomb interaction and the periodic boundary conditions. We derive the Projector Augmented-Wave (PAW) energy and hamiltonian with a special care on the potentials from Coulomb interaction. By explicitly treating the background compensation charge, we find a new term in the total energy of charged cells and in the potential. We show that this background term is needed to accurately reproduce all-electron calculations of the formation energy of a charged defect. In particular, the previous PAW expressions were spuriously sensitive to the pseudization conditions and this artifact is removed by the background term. This PAW derivation also provides insights into the norm-conserving pseudopotential framework. We propose then an alternative definition for the total energy of charged cells and for the potential within this framework.

  6. Prolonged urinary leakage in the postoperative period of renal hydatic cyst treatment with oral desmopressin: a case report

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    Ceylan Cavit

    2012-10-01

    Full Text Available Abstract Introduction Prolonged extravasation after renal and ureter surgeries is a bothersome situation for both the patient and the doctor. It is usually related to the suture line not being watertight. The contact between urine and the edges of the wound also delay healing of the wound. In this situation, the first thing to do is to break the contact between the wound and the urine by inserting an adequate stent. Sometimes, this process is not enough. We approached this problem with a different treatment method for a case involving prolonged drainage. Case presentation A 52-year-old Caucasian woman who presented at our clinic with right flank pain was operated on due to a renal hydatic cyst, and cyst removal was performed. On follow-up, prolonged urinary leakage was observed and a desmopressin treatment was started on the patient. Drainage was greatly reduced after desmopressin was started and there was no drainage on the fifth day. Conclusion Prolonged extravasation is a bothersome situation and there can be many reasons for this. Whenever traditional approaches are not enough, oral desmopressin therapy can be started reliably if there are no contraindications for the patient. Eventually, contact between urine and the suture site will cease and therefore the fever and healing time will be shortened.

  7. Cardiac atrial circadian rhythms in PERIOD2::LUCIFERASE and per1:luc mice: amplitude and phase responses to glucocorticoid signaling and medium treatment.

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    Daan R van der Veen

    Full Text Available Circadian rhythms in cardiac function are apparent in e.g., blood pressure, heart rate, and acute adverse cardiac events. A circadian clock in heart tissue has been identified, but entrainment pathways of this clock are still unclear. We cultured tissues of mice carrying bioluminescence reporters of the core clock genes, period 1 or 2 (per1(luc or PER2(LUC and compared in vitro responses of atrium to treatment with medium and a synthetic glucocorticoid (dexamethasone [DEX] to that of the suprachiasmatic nucleus (SCN and liver. We observed that PER2(LUC, but not per1(luc is rhythmic in atrial tissue, while both per1(luc and PER2(LUC exhibit rhythmicity in other cultured tissues. In contrast to the SCN and liver, both per1(luc and PER2(LUC bioluminescence amplitudes were increased in response to DEX treatment, and the PER2(LUC amplitude response was dependent on the time of treatment. Large phase-shift responses to both medium and DEX treatments were observed in the atrium, and phase responses to medium treatment were not attributed to serum content but the treatment procedure itself. The phase-response curves of atrium to both DEX and medium treatments were found to be different to the liver. Moreover, the time of day of the culturing procedure itself influenced the phase of the circadian clock in each of the cultured tissues, but the magnitude of this response was uniquely large in atrial tissue. The current data describe novel entrainment signals for the atrial circadian clock and specifically highlight entrainment by mechanical treatment, an intriguing observation considering the mechanical nature of cardiac tissue.

  8. Cardiac Atrial Circadian Rhythms in PERIOD2::LUCIFERASE and per1:luc Mice: Amplitude and Phase Responses to Glucocorticoid Signaling and Medium Treatment

    Science.gov (United States)

    Xi, Yang; Li, Lei; Duffield, Giles E.

    2012-01-01

    Circadian rhythms in cardiac function are apparent in e.g., blood pressure, heart rate, and acute adverse cardiac events. A circadian clock in heart tissue has been identified, but entrainment pathways of this clock are still unclear. We cultured tissues of mice carrying bioluminescence reporters of the core clock genes, period 1 or 2 (per1luc or PER2LUC) and compared in vitro responses of atrium to treatment with medium and a synthetic glucocorticoid (dexamethasone [DEX]) to that of the suprachiasmatic nucleus (SCN) and liver. We observed that PER2LUC, but not per1luc is rhythmic in atrial tissue, while both per1luc and PER2LUC exhibit rhythmicity in other cultured tissues. In contrast to the SCN and liver, both per1luc and PER2LUC bioluminescence amplitudes were increased in response to DEX treatment, and the PER2LUC amplitude response was dependent on the time of treatment. Large phase-shift responses to both medium and DEX treatments were observed in the atrium, and phase responses to medium treatment were not attributed to serum content but the treatment procedure itself. The phase-response curves of atrium to both DEX and medium treatments were found to be different to the liver. Moreover, the time of day of the culturing procedure itself influenced the phase of the circadian clock in each of the cultured tissues, but the magnitude of this response was uniquely large in atrial tissue. The current data describe novel entrainment signals for the atrial circadian clock and specifically highlight entrainment by mechanical treatment, an intriguing observation considering the mechanical nature of cardiac tissue. PMID:23110090

  9. Biomineralization of azo dye bearing wastewater in periodic discontinuous batch reactor: Effect of microaerophilic conditions on treatment efficiency.

    Science.gov (United States)

    Naresh Kumar, A; Nagendranatha Reddy, C; Venkata Mohan, S

    2015-01-01

    The present study illustrates the influence of microaerophilic condition on periodic discontinuous batch reactor (PDBR) operation in treating azo dye containing wastewater. The process performance was evaluated with the function of various dye load operations (50-750 mg/l) by keeping the organic load (1.6 kg COD/m(3)-day) constant. Initially, lower dye operation (50mg dye/l) resulted in higher dye [45 mg dye/l (90%)] and COD [SDR: 1.29 kg COD/m(3)-day (92%)] removal efficiencies. Higher dye load operation (750 mg dye/l) also showed non-inhibitory performance with respect to dye [600 mg dye/l (80%)] and COD [1.25 kg COD/m(3)-day (80%)] removal efficiencies. Increment in dye load showed increment in azo reductase and dehydrogenase activities (39.6 U; 4.96 μg/ml; 750 mg/l). UV-Vis spectroscopy (200-800 nm), FTIR and (1)H NMR studies revealed the disappearance of azo bond (-NN-). First derivative cyclic voltammogram supported the involvement of various membrane bound redox shuttlers, viz., cytochrome-C, cytochrome-bc1 and flavoproteins (FAD (H)).

  10. Administration of Mycobacterium phlei cell wall-nucleic acid complex in the immediate postoperative period for the treatment of non-muscle-invasive bladder cancer

    Science.gov (United States)

    Morales, Álvaro

    2016-01-01

    Introduction: This review sought to investigate the safety of intravesical administration of Mycobacterium phlei cell wall-nucleic acid (MCNA) in the immediate postoperative period after biopsy/resection for non-muscle-invasive bladder cancer (NMIBC). Methods: Patients with NMIBC who failed bacillus Calmette-Guérin (BCG) therapy and at high risk of recurrence and progression participated in this study. Treatment involved an induction phase of six weeks and maintenance of three weekly instillations every six months for two years. Biopsies were mandatory at six months and resections/biopsies as indicated. Of the 129 patients enrolled, 18 (14%) received one or more instillations of MCNA within 24 hours of an endoscopic procedure for a total of 32 instillations. Results: Fourteen patients (78%) received MCNA in the immediate postoperative period. Two (11%) received treatment the day after surgery, but a second treatment immediately after a transurethral resection of the bladder tumour (TURBT). The remaining two patients received an instillation each the day after surgery. Adverse events (AEs) occurred in 31.3% of those treated immediately after the procedure; they were mild, limited to the lower urinary tract, and not drug-related. Only one patient experienced systemic symptoms of moderate severity. None of the AEs resulted in postponement of treatment. There were no AEs among those receiving MCNA the day after surgery. Conclusions: The dual mechanism of action of MCNA suggests that early treatment would take advantage of its chemotherapeutic (pro-apoptotic) activity. Concerns about early administration due to the presence of live bacteria are circumvented with this sterile preparation. These preliminary results warrant further investigation to confirm the safety of perioperative administration of MCNA. PMID:27800054

  11. Case report: Successful treatment of recurrent chordoma and bilateral pulmonary metastases following an 11-year disease-free period

    Science.gov (United States)

    Erkmen, Cherie P.; Barth, Richard J.; Raman, Vignesh

    2014-01-01

    INTRODUCTION Chordomas are rare but aggressive tumors due to local recurrence and distant metastases. They originate commonly in the sphenooccipital and sacrococcygeal regions, and metastasize to the lungs, bone, skin, liver, and lymph nodes. They occur more frequently in men and people over the age of 40. PRESENTATION OF CASE A 28 year-old female presented with sacrococcygeal chordoma for which she received wide local excision and adjuvant radiation therapy. She enjoyed an unusual disease-free survival for 11 years until a routine surveillance scan of the pelvis identified local recurrence. Further work up revealed bilateral pulmonary metastases. She underwent local excision of the recurrent tumor and video-assisted thoracoscopic (VATS) wedge resection of pulmonary metastases. She also received adjuvant radiation therapy to the recurrent resection bed. Two years later, she remains free of disease and symptoms. DISCUSSION Chordomas are commonly insensitive to chemotherapy and radiation, making surgery the most successful therapeutic modality. However, there are few guidelines on the surveillance and treatment of recurrent chordoma. We report success with aggressive surgical resection of recurrence and metastasis as well as adjuvant radiation therapy. CONCLUSION The prolonged survival of our patient underscores the importance of (1) aggressive surgical resection of chordoma, whether primary, recurrent, or metastatic, with adjuvant radiation therapy, (2) minimization of surgical seeding of tumor, and (3) diligent cancer surveillance. PMID:24907541

  12. The course of pain drawings during a 10-week treatment period in patients with acute and sub-acute low back pain

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    Delaney Heléne

    2006-08-01

    Full Text Available Abstract Background Pain drawings are widely used as an assessment of patients' subjective pain in low back pain patients being considered for surgery. Less work has been done on primary health care patients. Moreover, the possible correlation between pain drawing modalities and other pain assessment methods, such as pain score and functional variables needs to be described. Thus, the objectives were to describe the course of pain drawings during treatment in primary health care for low back pain patients. Methods 160 primary health care outpatients with acute or sub-acute low back pain were studied during 10 weeks of a stay active concept versus manual therapy in addition to the stay active concept. The patients filled out 3 pain drawings each, at baseline and after 5 and 10 weeks of treatment. In addition the patients also reported pain and functional variables during the 3 measurement periods. Results The proportion of areas marked, the mean number of areas marked (pain drawing score, mean number of modalities used (area score, and the proportion of patients with pain radiation all decreased during the 10-week treatment period. Most of the improvement occurred during the first half of the period. The seven different pain modalities in the pain drawing were correlated to pain and functional variables. In case of no radiation some modalities were associated with more pain and disability than others, a finding that grew stronger over time. For patients with pain radiation, the modality differences were smaller and inconsistent. Conclusion Pain modalities are significantly correlated with pain and functional variables. There is a shift from painful modalities to less painful ones over time.

  13. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period

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    Maria-Angeliki Gkini

    2014-01-01

    Full Text Available Background: Platelet-rich plasma (PRP is defined as an autologous concentration of plasma with a greater count of platelets than that of whole blood. Its action depends on the released growth factors from platelets. It has been investigated and used in numerous fields of medicine. Recently, PRP has received growing attention as a potential therapeutic tool for hair loss. Aims: To evaluate the efficacy and safety of PRP injections in the scalp of patients with androgenetic alopecia. Settings and Design: Prospective cohort study. Materials and Methods: 20 patients, 18 males and 2 females, with androgenetic alopecia were enrolled in the study. PRP was prepared using a single spin method (Regenlab SA. Upon activation, it was injected in the androgen-related areas of scalp. Three treatment sessions were performed with an interval of 21 days and a booster session at 6 months following the onset of therapy. Statistical Analysis: Statistical analysis of the data was performed using the Statistical Package for the Social Sciences (SPSS, version 19.0 (IBM, NY, USA. Results: Hair loss reduced and at 3 months it reached normal levels. Hair density reached a peak at 3 months (170.70 ± 37.81, P < 0.001. At 6 months and at 1 year, it was significantly increased, 156.25 ± 37.75 (P < 0.001 and 153.70 ± 39.92 (P < 0.001 respectively, comparing to baseline. Patients were satisfied with a mean result rating of 7.1 on a scale of 1-10. No remarkable adverse effects were noted. Conclusions: Our data suggest that PRP injections may have a positive therapeutic effect on male and female pattern hair loss without remarkable major side effects. Further studies are needed to confirm its efficacy.

  14. Periodic functions with variable period

    OpenAIRE

    Pryjmak, M. V

    2010-01-01

    The examples of rhythmical signals with variable period are considered. The definition of periodic function with the variable period is given as a model of such signals. The examples of such functions are given and their variable periods are written in the explicit form. The system of trigonometric functions with the variable period is considered and its orthogonality is proved. The generalized system of trigonometric functions with the variable period is also suggested; some conditions of it...

  15. Mortality and loss-to-follow-up during the pre-treatment period in an antiretroviral therapy programme under normal health service conditions in Uganda

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    Levin Jonathan

    2009-08-01

    Full Text Available Abstract Background In many HIV programmes in Africa, patients are assessed clinically and prepared for antiretroviral treatment over a period of 4–12 weeks. Mortality rates following initiation of ART are very high largely because patients present late with advanced disease. The rates of mortality and retention during the pre-treatment period are not well understood. We conducted an observational study to determine these rates. Methods HIV-infected subjects presenting at The AIDS Support Clinic in Jinja, SE Uganda, were assessed for antiretroviral therapy (ART. Eligible subjects were given information and counselling in 3 visits done over 4–6 weeks in preparation for treatment. Those who did not complete screening were followed-up at home. Survival analysis was done using poisson regression. Results 4321 HIV-infected subjects were screened of whom 2483 were eligible for ART on clinical or immunological grounds. Of these, 637 (26% did not complete screening and did not start ART. Male sex and low CD4 count were associated independently with not completing screening. At follow-up at a median 351 days, 181 (28% had died, 189 (30% reported that they were on ART with a different provider, 158 (25% were alive but said they were not on ART and 109 (17% were lost to follow-up. Death rates (95% CI per 100 person-years were 34 (22, 55 (n.18 within one month and 37 (29, 48 (n.33 within 3 months. 70/158 (44% subjects seen at follow-up said they had not started ART because they could not afford transport. Conclusion About a quarter of subjects eligible for ART did not complete screening and pre-treatment mortality was very high even though patients in this setting were well informed. For many families, the high cost of transport is a major barrier preventing access to ART.

  16. Brain metastases of solid tumour. Treatment distribution and analysis of survival in the period 1/01/2004 to 31/12/2008

    International Nuclear Information System (INIS)

    Objective: To retrospectively analyze the characteristics, treatments and survival analysis in patients with solid tumors with brain metastases (E IV) assisted in Unit Neuro-Oncology over a period of five years. Patients and methods: The records of patients (pts) with diagnosis of brain metastases from solid tumors assisted in Neuro-Oncology Unit, from 1/01/2004 and 31/12/2008. Results: 51 new patients carriers of brain metastases were treated with solid tumors. The median age at diagnosis was 57 years, ranging from 30 to 75. They corresponded to the male 37 and female 14 ratio 2.5 / 1. The majority was presented as metastases 31/51. The location was in the supratentorial region in 27 cases, posterior fossa in 11 and 13 were supra and infratentorial. In only 5 patients cranial MRI was performed in only one case and it changed the therapeutical strategy. In 35 patients he corresponded to the lung primary tumor (CBP), following cancer renal (5/51). Within the CBP, the most common histologic subtypes were to large cells and adenocarcinomas, 11 and 10, respectively. In 32 patients were not found dissemination elsewhere. Surgery + RT was performed in 30 cases, in 11 exclusive RT, exclusive surgery in 4 and 3 patients symptomatic treatment. In 39 cases did not Systemic treatment diagnosis. When a progression was only diagnosed It could make systemic treatment 5 pts. The median survival was 15.4 weeks (1-301 weeks). Conclusions: Lung cancer is the most common source of metastases brain, with a poor survival. The results of other characteristics patients, systemic treatments performed and survival according to the treatments performed will be presented during the congresss

  17. Comparison of different combined treatment processes to address the source water with high concentration of natural organic matter during snowmelt period

    Institute of Scientific and Technical Information of China (English)

    Pengfei Lin; Xiaojian Zhang; Jun Wang; Yani Zeng; Shuming Liu; Chao Chen

    2015-01-01

    The source water in one forest region of the Northeast China had very high natural organic matter (NOM) concentration and heavy color during snowmelt period.The efficiency of five combined treatment processes was compared to address the high concentration of NOM and the mechanisms were also analyzed.Conventional treatment can hardly remove dissolved organic carbon (DOC) in the source water.KMnO4 pre-oxidization could improve the DOC removal to 22.0%.Post activated carbon adsorption improved the DOC removal of conventional treatment to 28.8%.The non-sufficient NOM removal could be attributed to the dominance of large molecular weight organic matters in raw water,which cannot be adsorbed by the micropore upon activated carbon.O3 + activated carbon treatment are another available technology for eliminating the color and UV254 in water.However,its performance of DOC removal was only 36.4%,which could not satisfy the requirement for organic matter.The limited ozone dosage is not sufficient to mineralize the high concentration of NOM.Magnetic ion-exchange resin combined with conventional treatment could remove 96.2% of color,96.0% of UV254 and 87.1% of DOC,enabling effluents to meet the drinking water quality standard.The high removal efficiency could be explained by the negative charge on the surface of NOM which benefits the static adsorption of NOM on the anion exchange resin.The results indicated that magnetic ion-exchange resin combined with conventional treatment is the best available technology to remove high concentration of NOM.

  18. GLP-1 receptor agonist treatment increases bone formation and prevents bone loss in weight-reduced obese women

    DEFF Research Database (Denmark)

    Iepsen, Eva Pers Winning; Lundgren, Julie Rehné; Hartmann, Bolette;

    2015-01-01

    markers (CTX-1 and P1NP) were investigated before, after weight loss and after 52 weeks weight maintenance. Primary end points: Change in BMC and bone markers after 52 weeks weight maintenance with or without GLP-1 RA treatment. RESULTS: Total, pelvic and arm-leg BMC decreased during weight maintenance....... In the liraglutide group, the bone formation marker P1NP increased by 16% (7±3 μg/L) vs a 2% (-1±4 μg/L) decrease in the control group (pmaintenance phase. CONCLUSIONS: Treatment with a long-acting GLP-1 RA increased bone formation by 16......% and prevented bone loss after weight loss obtained through a low calorie-diet, supporting its role as a safe weight-lowering agent....

  19. ASME N511-19XX, Standard for periodic in-service testing of nuclear air treatment, heating, ventilating and air conditioning systems

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-08-01

    A draft version of the Standard is presented in this document. The Standard covers the requirements for periodic in-service testing of nuclear safety-related air treatment, heating, ventilating, and air conditioning systems in nuclear facilities. The Standard provides a basis for the development of test programs and does not include acceptance criteria, except in cases where the results of one test influence the performance of other tests. The Standard covers general inspection and test requirements, reference values, inspection and test requirements, generic tests, acceptance criteria, in-service test requirements, testing following an abnormal incident, corrective action requirements, and quality assurance. Mandatory appendices provide a visual inspection checklist and four test procedures. Non-mandatory appendices provide additional information and guidance on mounting frame pressure leak test procedure, corrective action, challenge gas substitute selection criteria, and test program development. 8 refs., 10 tabs.

  20. THE SUCCESSFUL TREATMENT OF A PERIPHERAL VENO-VENOUS EXTRACORPOREAL MEMBRANE OXYGENATION FOR SEVERE ACUTE RESPIRATORY FAILURE IN THE EARLY PERIOD AFTER ADULT LIVER TRANSPLANTATION

    Directory of Open Access Journals (Sweden)

    V. N. Poptsov

    2014-01-01

    Full Text Available Aim: of our clinical study was to present own experience of veno-venous extracorporeal membrane oxygenation (VV ECMO for the treatment of an adult patient (female, 28 yrs, 150 cm, 35 kg with acute respiratory distress syndrome (ARDS in the early period after liver transplantation against satisfactory liver graft function. Materials and methods. Double-lumen cannula 22 F was placed percutaneously in the right internal jugular vein. The ext- racorporeal contour reduced in length and the polymethylpeptene oxygenator (priming volume 175 ml were also. Results. In 1 hour after the beginning of VV ECMO, we registered the noted improvement of arterial blood gas and acid-base balance (regress of respiratory acidosis, improvement of arterial oxygenation which allowed us to use the «protective» mode of mechanical ventilation. Improvement of gas exchange and regress of clinical and radiological manifestations of ARDS allowed for VV ECMO weaning and decannulation on day 7. The patient was discharged from ICU and then from our Centre to a homestay respectively on the 9th and 16th day after VV ECMO weaning with the satisfactory liver graft and lungs function. Conclusion. VV ECMO can be successfully applied to correct the life-threatening acute respiratory failure in the early period after liver transplantation. 

  1. Reduced gastric acid production in burn shock period and its significance in the prevention and treatment of acute gastric mucosal lesions

    Institute of Scientific and Technical Information of China (English)

    Li Zhu; Zhong Cheng Yang; Ao Li; De Chang Cheng

    2000-01-01

    AIM To investigate the changes of gastric acid production and its mechanism in shock period of severe burn in rats.METHODS A rat model with 30% TBSA fullthickness burn injury was employed and the gastric acid production, together with gastric mucosal blood flow (GMBF) and energy charge ( EC ) were measured serially within 48h postburn.RESULTS The gastric acid production in the acute shock period was markedly inhibited after severe burn injury. At the 3rd h postburn, the gastric juice volume, total acidity and acid output were already significantly decreased (P<0.01), and reached the lowest point,0.63mL/L ± 0.20mL/L, 10.81mmol/L ±2.58mmol/L and 2.23 mmol/h ± 0.73mmol/h respectively, at the 12th h postburn. Although restored to some degree 24 h after thermal injury, the variables above were still statistically lower, compared with those of control animals at the 48th h postburn. The GMBF and EC were also significantly reduced after severe burns, consistent with the trend of gastric acid production changes.CONCLUSION Gastric acid production, as well as GMBF and EC was predominantly decreased in the early postburn stage, suggesting that gastric mucosal ischemia and hypoxia with resultant disturbance in energy metabolism, but not gastric acid proper, might be the decisive factor in the pathogenesis of AGML after thermal injury, and that the preventive use of anti-acid drugs during burn shock period was unreasonable in some respects. Therefore,taking effective measures to improve gastric mucosal blood perfusion as early as possible postburn might be more preferable for the AGML prevention and treatment.

  2. Positive performance and health effects of a football training program over 12 weeks can be maintained over a 1-year period with reduced training frequency

    DEFF Research Database (Denmark)

    Randers, Morten Bredsgaard; Nielsen, Jens Jung; Krustrup, Birgitte Rejkjær;

    2010-01-01

    unaltered for CG. In conclusion, positive adaptations in cardiovascular fitness obtained over 12 weeks of regular recreational football training can be maintained over a 1-year period with a reduced training frequency, with further development in musculo-skeletal fitness.......We examined whether improvements in the performance and health profile of an intensive 12-week football intervention could be maintained with a reduced training frequency. Seventeen healthy untrained males completed the study. Ten subjects trained 2.4 times/week for 12 weeks and another 52 weeks...... (Pmuscle mass (11%), mean fiber area (10%) and citrate synthase activity (18%) were higher (P

  3. Kerathocyst odontogenic tumor: Importance of selection the best treatment modality and a periodical follow-up to prevent from recurrence: A case report and literature review

    Directory of Open Access Journals (Sweden)

    Nasim Jafaripozve

    2013-01-01

    Full Text Available The keratocystic odontogenic tumor (KCOT is a relatively common oral and maxillofacial lesion with specific characteristics such us rapid growth, extension into the surrounding tissues and high rates of recurrence. Various treatment modalities have been reported. Due to the very thin and friable lining characteristic of the tumor, enucleation can be difficult undertaken and for this reason it is associated with the highest recurrence rates. A 22-year-old male referred to our clinic due to a slight expansion in the right mandible from 2 years ago. He has a history of occurrence of KCOT in this region that was treated surgically by enucleation and curettage 5 years ago. Cone beam computed tomography showed a multilocular radiolucent lesion that extended from the angle of the mandible to the symphysis. Incisional biopsy showed a KCOT recurrence that surgically treated with resection of the right mandible by continuity preservation. Selection of the best treatment modality and also a periodical lifelong follow-up is very important to reduce the rate of recurrence and morbidity of the patient.

  4. Surgical Treatment of 55 Patients with Pressure Ulcers at the Department of Plastic and Reconstructive Surgery Kosovo during the Period 2000–2010: A Retrospective Study

    Directory of Open Access Journals (Sweden)

    Shkelzen B. Duci

    2013-01-01

    Full Text Available Objective. The objective of this study is to determine the incidence of PUs, the distribution of PUs, common injuries contributing to the occurrence of PUs in patients admitted to the Department of Plastic and Reconstructive Surgery Kosovo for surgical interventions of PUs, localization of PUs in body, the topical treatment of pressure ulcers before surgical intervention, the methods of surgical interventions, number of surgical interventions, duration of treatment, complications, and mortality. Materials and Methods. This study includes 55 patients with PUs treated surgically in 2000–2010 period in the Department of Plastic and Reconstructive Surgery Kosovo. The data were collected and analyzed from the archives and protocols of the University Clinical Center of Kosovo. Data processing was done with the statistical package In Stat 3. From statistical parameters arithmetic median and standard deviation were calculated. Data testing is done with χ2-test and the difference is significant if P<0.05. Conclusion. Despite preventive measures against PUs, the incidence of Pus remains high.

  5. Treatment of Diabetic Foot Ulcer Using Matriderm In Comparison with a Skin Graf

    Directory of Open Access Journals (Sweden)

    Hyojin Jeon

    2013-07-01

    Full Text Available Background For patients with neuropathy, vasculopathy, and impairment of wound healing, treatment of a diabetic foot ulcer poses many challenges. A large number of dermal analogues have been invented in an effort to overcome these challenges. Matriderm, a dermal analogue, is made from bovine collagen and elastin. This study was conducted in order to evaluate the effectiveness of Matriderm for treatment of diabetic foot ulcers, in comparison with skin grafting.Methods Sixty patients with diabetic foot ulcer were included in this prospective study. The average age of the patients, who had type II diabetes mellitus, was 58 years old. The patients were allocated to an experimental or control group with their consents. The patients were selected with their consent for inclusion in an experimental group and a control group. Patients in the experimental group received a Matriderm appliance and a split-thickness skin graft, while those in the control group received only a split-thickness skin graft.Results A shorter hospitalization period (7.52 weeks was observed in the experimental group than in the control group (9.22 weeks, and a shorter period of time (8.61 weeks was required for complete healing, compared with the control group (12.94 weeks, with statistical significance (P<0.05. A higher elasticity ratio of the affected side to the non-affected side was observed in the experimental group, compared with the control group (P<0.01.Conclusions Matriderm enables effective healing and improves elasticity in treatment of patients with diabetic foot ulcer.

  6. Effect of estradiol, vitamin A, E and selenium treatment with varying sexual rest period on recovery rate in cross-bred cows with chronic endometritis

    Directory of Open Access Journals (Sweden)

    Dipyaman Sengupta

    2013-04-01

    Full Text Available Aim:This work was done to study the effect of vitamin A, E and Se with varying sexual rest period in cross-bred cows with chronic endometritis. Materials and Methods: Cross-bred cows (n=396 from different villages of West Bengal with purulent or muco-purulent discharge with a history of infertility and repeat breeding for 3 to 6 months were chosen for the present study. These cows received uterine wash with lugol's iodine, intra-uterine and parenteral antibiotics and de-worming as general treatment. They were then divided into six groups viz. SR12 × EV (n=59, SR12 × Control (n=67, SR21 × EV (n=65, SR21 × Control (n=70, SR24 × EV (n=66, SR24 × Control (n=69 receiving sexual rest of 12 (SR12, 21 (SR21 and 24 (SR24 days with (EV group or without (control estradiol + vitamin A, E and Se. Results: The results indicate that the recovery rate of EV and control group was 76.27 % and 37.31 % respectively (P<0.01 in SR 12, 72.31 % and 47.14 % respectively (P<0.01 in SR 21 and 92.41 % and 63.77 % respectively (P<0.01 in SR 24. SR 24 showed significantly better (P<0.01 recovery rate compared to SR 12 and SR 21. Lowest recovery and conception rate of EV and control group in SR 12 might be due to insufficient time for the recovery of endometrium. Conclusion: The results indicate that parenteral and intra-uterine antibiotics had synergistic effect with estradiol, vitamin A, E and Se treatment in recovery from endometritis, though a minimum time interval is required for complete recovery of the endometrium for best conception rate. [Vet World 2013; 6(2.000: 106-108

  7. Analysis of rehabilitation treatment and nursing of stroke recovery period%中风恢复期的康复治疗及护理分析

    Institute of Scientific and Technical Information of China (English)

    吴凤鸣

    2016-01-01

    目的:分析中风恢复期的康复治疗及护理方法。方法:选取我院在2012年3月~2014年3月收取的中风恢复期患者80例,并对其进行对应的康复治疗和护理。结果:康复治疗后,患者的生活自理能力明显提高,入院时患者生活自理能力评分是(1.3±1.1)分;入院后一个月,评分为(8.8±3.5)分;入院后半年,评分为(13.2±4.1)分。所以治疗的前后差异对比有统计学意义(P<0.05)。结论:对中风恢复期的患者实施对应的康复治疗和护理是必要的,可以加速提升患者的自理能力和生活质量。值得临床推广使用。%Objective To analyze the rehabilitation and nursing of stroke recovery. Methods Choose from March 2012 to March 2014 to collect 80 cases of patients with stroke recovery period, carry on the corresponding rehabilitation treatment and nursing.Results After rehabilitation, self-care ability of patients significantly improved patient admission daily living score was (1.3 ± 1.1) points; one month after admission, a score of (8.8 ± 3.5) points; six months after admission, scoring was (13.2 ± 4.1) points. So the difference before and after treatment was statistically significant comparison (P <0.05).Conclusion The implementation of recovery for stroke patients corresponding rehabilitation treatment and care is necessary, can be accelerated to enhance self-care ability and quality of life of patients. Worthy of clinical use.

  8. Randomized, observer-blind, split-face study to compare the irritation potential of 2 topical acne formulations over a 14-day treatment period.

    Science.gov (United States)

    Ting, William

    2012-08-01

    This randomized, observer-blind, split-face study assessed the irritation potential and likelihood of continued use of clindamycin phosphate 1.2%--benzoyl peroxide (BPO) 2.5% gel or adapalene 0.1%--BPO 2.5% gel once daily over a 14-day treatment period in 21 participants (11 males; 10 females) with acne who were 18 years or older. Investigator clinical assessment (erythema and dryness) and self-assessment (dryness and burning/stinging) were performed at baseline and each study visit (days 1-14) using a 4-point scale (O = none; 3 = severe). Transepidermal water loss (TEWL) and corneometry measurements were performed at baseline and days 3, 5, 7, 9, 11, and 14. Lesions were counted at baseline and on day 14. Participant satisfaction questionnaires were completed on days 7 and 14. At the end of the study, investigators reported none or only mild erythema in 86% (18/21) of participants treated with clindamycin phosphate 1.2%--BPO 2.5% gel compared with 62% (13/21) of participants treated with adapalene 0.1%--BPO 2.5% gel. No severe erythema was reported with clindamycin phosphate 1.2%--BPO 2.5% gel. Adapalene 0.1%--BPO 2.5% gel was prematurely discontinued due to severe erythema in 1 participant on day 5 and a second participant on day 9. Additionally, 2 more participants reported severe erythema on day 14. Mean erythema scores were 0.9 (mean change from baseline, 0.7) with clindamycin phosphate 1.2%--BPO 2.5% gel and 1.4 (mean change from baseline, 1.3) with adapalene 0. 1%--BPO 2.5% gel on day 14 (P BPO 2.5% gel. Continued use and efficacy results for the treatment of acne were influenced by the potential of the product to cause irritation and the participant preferences. Irritation potential was more pronounced and severe with adapalene 0.1%--BPO 2.5% gel. Undoubtedly, as a result more participants preferred treatment with clindamycin phosphate 1.2%--BPO 2.5% gel and were more likely to continue to use the product.

  9. Anti-infective treatment for the HIV-infected patient during perioperative period%围手术期HIV感染者的抗感染治疗

    Institute of Scientific and Technical Information of China (English)

    刘保池; 张磊; 李垒; 司炎辉; 宋言峥; 赵中辛

    2012-01-01

      Objective:To investigate anti-infective treatments in HIV-infected surgical patients during the perioperative period. Methods 〓 A retrospective study of sepsis and surgical site infections (SSIs) was conducted in 266 HIV-infected patients from January 2009 to December 2011 in Shanghai Public Health Clinical Center. The patients were divided into 3 groups based on CD4 cells counts in the preoperative period: group A (<200 cell/μl), group B (200-349 cell/μl) and group C (≥350 cell/μl). Highly active anti-retrovirus therapy (HAART) was started in group B. Preoperative antibiotic medication SMZ and fluconazole against Pneumocystis carinii pneumonia (PCP) and other fungal infection was started in group A. No special treatment in group C. Results〓There were only 6 patients dead at 30 days after surgery, with the death rate of 2.3%. Sepsis appeared in 110 patients (41.3%). Patients in group A were more likely to get sepsis than patients in the other two groups (P <0.01). Conclusion〓Complete evalua- tion of surgical risk and suitable perioperative anti-infective treatment may lead to better outcome for HIV-infected surgical patients.%  〓〓[]〓目的〓探讨 HIV 感染者围手术期合理的抗感染治疗.方法〓回顾性分析上海市公共卫生临床中心外科2009年1月至2011年12月救治的266例 HIV 感染患者围手术期临床资料,根据患者术前 CD4 T 淋巴细胞水平分 A 组<200 cell/μl,B 组200~349 cell/μl 和 C 组≥350 cell/μl 三组,对 B 组给予抗 HIV 病毒治疗,对 A 组给予抗 HIV 病毒、磺胺甲唑(SMZ)和氟康唑预防肺孢子虫和真菌感染,对已经合并结核、真菌等机会性感染者给予相应的抗感染治疗.对 C组无特殊处理.结果〓经适当的抗感染治疗,266例患者手术后30 d 内死亡6例,病死率2.3%.110例发生脓毒症,脓毒症发生率41.3%.A 组脓毒症发病率明显高于 B 组和 C 组(P <0.01).结论〓精细的手术与合理的围手术

  10. 针刺治疗周围性面瘫(急性期)的系统评价%Acupuncture Treatment of Peripheral Facial Paralysis(Acute Period)

    Institute of Scientific and Technical Information of China (English)

    潘江; 章薇; 陈武善; 石文英

    2011-01-01

    Objective :To systematically analyze the effectiveness of acupuncture for the treatment of peripheral facial paralysis at acute period.Methods:Through the VIP datebase, index.htm Shuofang doctoral dissertation,the national databases, Wanfang database electronic retrieval and refer to the relevant professional information and network information.The test data taken by the Cochrane pensonnel provide Revman4.2.7 on Meta analysis.Results:Through selecting, only eight articles which met criteria were chosen from total checked 79 related paper, using Jadad rating criteria for 8 articles methodological quality evaluation, including a literature which is of high quality and the rest are low quality documents.We can see that acupuncture trcatment of peripheral facial paralysis has a better efficacy.The difference was statistically significant( Z = 5.89, P < 0.00001 ).Conclusion:Using acupuncture treatment for peripheral facial paralysis at acute period is better, and it could shorten the time.However, the quality of RCT literatures is not high, and quantity is less.This study still needs further large - scale development to further improve the intensity of evidence.%目的:评价针刺治疗周围性面瘫急性期的疗效.方法:通过对维普网、中国知网、全国硕博士论文数据库、万方数据库进行电子检索以及查阅相关的专业资料和网络信息.试验数据采取由Cochrane协作网提供的Revman4.2.7进行Meta分析.结果:共查到79篇相关文献,经过筛选,只有8篇文章符合纳入标准,采用Jadad评分标准对8篇文献的方法学质量进行评价,其中1篇文献质量高,其余均是低质量文献.Meta分析显示,周围性面瘫急性期针刺治疗结果比不使用针刺治疗的效果好,其差异有统计学意义(P<0.01).结论:现有的临床证据表明,周围性面瘫的急性期应用针刺治疗比不使用针刺治疗更能改善病人的症状,提高治疗的效果,缩短面瘫恢复的时间.但是,由

  11. Surgical treatment of 137 cases with chronic subdural hematoma at the university clinical center of Kosovo during the period 2008-2012

    Directory of Open Access Journals (Sweden)

    Agon Y Mekaj

    2015-01-01

    Full Text Available Background: Chronic subdural hematoma (CSDH is frequent pathology in neurosurgical practice. The aim of this study is to present the first series of patients with CSDH, who got surgically treated in Clinic of Neurosurgery, University Clinical Center of Kosovo. Materials and Methods: This is a retrospective study that included 137 patients with CSDH who had been treated during the period 2008-2012. The data were collected and analyzed from the archives and protocols of the University Clinical Center of Kosovo. Patients were analyzed in many aspects such as age, gender, etiological factors, clinical features, localization, diagnoses, methods of surgical interventions, recurrences and mortality of patients. Results: From 137 patients with CSDH, 106 (77.3% were males and 31 (22.7% females. Average age of patients was 62.85 years. Analyzed according to the decades, the highest number of causes with CSDH was between 70 and 79 years (46%. The head trauma has been responsible for CSDH in 88 patients (64.3%, while the main symptom was headache (92 patients or 67.1%. One burr-hole trepanation with closed drainage system has been used in majority of cases (in 101 patients or 73.7%. The recurrence of CSDH was 6.5%, whereas mortality 2.9%. Conclusion: CSDH is more common in elderly patients. The male-female ratio is 3.4:1. Like other authors we also think that treatment with one burr-hole and drainage is a method of choice, because of its simplicity and safety.

  12. Radical hysterectomy in surgical treatment of invasive cervical cancer at the Department of gynecology and obstetrics in Novi Sad in the period 1993-2013.

    Directory of Open Access Journals (Sweden)

    Đurđević Srđan

    2015-01-01

    Full Text Available Introduction. During the period from 1993 - 2013, 175 women with invasive cervical cancer underwent radical hysterectomy sec. Wertheim-Meigs at the Department of Gynecology and Obstetrics, Clinical Center of Vojvodina in Novi Sad. Indications for radical hysterectomy comprise histopathologically confirmed invasive cervical cancer in stages I B 1 - II B according to the International Federation of Gynecology and Obstetrics. Material and Methods. Stage of the disease or extent of the disease spread to the adjacent structures was assessed in accordance with the International Federation of Gynecology and Obstetrics staging system from 2009. Exclusion criteria were all other stages of this disease: I A and stages higher than II B, as well as the absence of definite histological confirmation of the cervical cancer (primary endometrial or vaginal cancer which infiltrates the uterine cervix. Prior the operation, the following had to be done: the imaging of pelvis and abdomen, chest X-ray in two directions, electrocardiography, internist and anesthesiological examination. Results. The patients’ age ranged from 24-79 years (x : 46 years, and the operation duration was 120-300 minutes (x : 210 min.. Stage I B 1 was found in 64.6% of operated patients, 14.8% of the patients were in stage I B 2, 9.1% were in stage II A and 11.4 % were in stage II B. Blood loss during the operation ranged from 50-800 ml (on average 300 ml, and the number of removed lymph nodes per operation was 14-75 (x : 32. Intraoperative and postoperative complications developed in 6.8% of and 17.7% of patients, respectively. Recurrence was reported in 22 (12.5% patients, most often in paraaortic lymph nodes (3.4% and parametria (2.8%, while the overall 5-year survival rate was 87% until 2008. Concluision. Wertheim-Meigs radical hysterectomy is a basic surgical technique for the treatment of initial stages of invasive cervical cancer.

  13. Treatment of delocalized electron transfer in periodic and embedded cluster DFT calculations: The case of Cu on ZnO (10(1)0).

    Science.gov (United States)

    Hellström, Matti; Spångberg, Daniel; Hermansson, Kersti

    2015-12-15

    We assess the consequences of the interface model-embedded-cluster or periodic-slab model-on the ability of DFT calculations to describe charge transfer (CT) in a particularly challenging case where periodic-slab calculations indicate a delocalized charge-transfer state. Our example is Cu atom adsorption on ZnO(10(1)0), and in fact the periodic slab calculations indicate three types of CT depending on the adsorption site: full CT, partial CT, and no CT. Interestingly, when full CT occurs in the periodic calculations, the calculated Cu atom adsorption energy depends on the underlying ZnO substrate supercell size, since when the electron enters the ZnO it delocalizes over as many atoms as possible. In the embedded-cluster calculations, the electron transferred to the ZnO delocalizes over the entire cluster region, and as a result the calculated Cu atom adsorption energy does not agree with the value obtained using a large periodic supercell, but instead to the adsorption energy obtained for a periodic supercell of roughly the same size as the embedded cluster. Different density functionals (of GGA and hybrid types) and basis sets (local atom-centered and plane-waves) were assessed, and we show that embedded clusters can be used to model Cu adsorption on ZnO(10(1)0), as long as care is taken to account for the effects of CT. PMID:26525161

  14. The prevalence, prevention and treatment of cattle epidemic during the Han-Tang Period%汉唐时期牛疫的流行与防治

    Institute of Scientific and Technical Information of China (English)

    韩毅

    2013-01-01

    About 21 times of cattle epidemic with rather strong infectivity happened during the Han-Tang Period,including 6 in the Eastern Han Dynasty,2 in the Jin Dynasty,4 in the Southern and Northern Dynasties,8 in the Tang Dynasty and 1 in the Five Dynasty.Most of them were spread along the Yellow River and the northern region of the Huai River.The type of cattle epidemic included the acute cattle plague,cattle bovine mange,cattle yellow fever and cattle rotten hoof disease,etc.Its occurrence and prevalence brought a serious influentce on the society of the Han and Tang Dynasties,causing massive mortality of farm cattle,and then the shortage of animal power,and threatening the agriculture,which drew the attention of the governments,physicians,agriculturists,astrologists and Taoists.The medical measures and economic measures were adopted for the prevention and treatment of cattle epidemic.Especially,prescriptions in the books of medicine and agriculture exerted positive effects on the containment of cattle epidemic.On the other hand,its prevalence and the mass mortality of farm cattle,in a way,promoted,to certain extent,the improvement of the government's function of relief,the updating of the methods of agriculture and the creation of new farm tools,and being regarded as a main cause for the technological innovation of agriculture.%汉唐时期约发生了21次传染性较强的牛疫,其中东汉时期6次,两晋时期2次,南北朝时期4次,唐代8次,五代1次,大多分布在黄河流域和淮河以北地区.牛疫种类主要有急性牛疫、牛疥癣病、牛黄热病和牛漏蹄病等.牛疫的发生和流行对汉唐社会产生了严重影响,不仅引起耕牛的大量死亡,而且造成畜力短缺,威胁到农业生产的正常进行,从而引起历代政府、医学家、农学家、星占学家、道家等不同社会阶层的关注和重视.防治牛疫的措施主要有医学措施和经济措施两方面,尤其是医学本草、方书、农书等类著

  15. Postnatal development and neoplastic disease pattern in NMRI mice after combined treatment with ethylnitrosourea and X-irradiation on different days of the fetal period.

    Science.gov (United States)

    Wiggenhauser, A; Schmahl, W

    1987-06-01

    Mice were X-irradiated on day 14, 15 or 16 of gestation with 1.0 Gy. This did not result in an increased tumour frequency in the offspring until 12 months. Mice treated with ethylnitrosourea (ENU) (45 mg/kg) on these gestation days developed a significantly increased tumour frequency in the lungs and liver, and in the ovaries after treatment on day 15 of gestation. Additionally this experiment was the first to show that ENU treatment on gestation day 14, 15 or 16 results in haemangiosarcomas of the subcutis at a low incidence (2.0, 2.4, 2.6 per cent). After combined treatment with these two agents in the sequence X+ENU and an interval of 4 h, a significantly increased incidence rate of animals with tumours was observed in the offspring treated on gestation day 14 or 16. Moreover, the treatment on gestation day 16 exhibited the highest tumour frequency per examined animal (5.7) of all treatment groups. This result is due to a relatively uniform increase of all tumor types. Within this pattern, the frequency of liver tumours was most marked. The diagnosed liver tumours were significantly augmented after X+ENU treatment on day 16. In the reverse sequence (ENU+X), the total tumour outcome was not significantly altered compared with the effects of ENU alone. However, detailed analysis also showed a significant augmentation of the liver tumour frequency with treatment on day 15. PMID:3496295

  16. Postnatal development and neoplastic disease pattern in NMRI mice after combined treatment with ethylnitrosourea and X-irradiation on different days of the fetal period

    Energy Technology Data Exchange (ETDEWEB)

    Wiggenhauser, A.; Schmahl, W.

    1987-06-01

    Mice were X-irradiated on day 14, 15 or 16 of gestation with 1.0 Gy. This did not result in an increased tumour frequency in the offspring until 12 months. Mice treated with ethylnitrosourea (ENU) (45 mg/kg) on these gestation days developed a significantly increased tumour frequency in the lungs and liver, and in the ovaries after treatment on day 15 of gestation. Additionally this experiment was the first to show that ENU treatment on gestation day 14, 15 or 16 results in haemangiosarcomas of the subcutis at a low incidence (2.0, 2.4, 2.6%). After combined treatment with these two agents in the sequence X + ENU and an interval of 4 h, a significantly increased incidence rate of animals with tumours was observed in the offspring treated on gestation day 14 or 16. Moreover, the treatment on gestation day 16 exhibited the highest tumour frequency per examined animal (5.7) of all treatment groups. This result is due to a relatively uniform increase of all tumor types. Within this pattern, the frequency of liver tumours was most marked. The diagnosed liver tumours were significantly augmented after X + ENU treatment on day 16. In the reverse sequence (ENU + X), the total tumour outcome was not significantly altered compared with the effects of ENU alone. However, detailed analysis also showed a significant augmentation of the liver tumour frequency with treatment on day 15.

  17. Effect of 131I in the treatment of hyperthyroidism at Hospital San Juan de Dios for the period from January 1, 2005 to December 31, 2007

    International Nuclear Information System (INIS)

    Radioactive iodine 131 (131I) is used for the treatment of hyperthyroidism at Hospital San Juan de Dios. The most common causes of hyperthyroidism have been Graves disease or diffuse goiter, toxic multinodular goiter and toxic nodular goiter, among others; but, the results are unknown and factors that have influenced the treatment with 131I. The study has included only patients with these causes, and have been administered radioactive iodine 131 as treatment. 180 cases have been treated with radioactive iodine, 75.0% have presented diffuse goiter, 22.2% multinodular goiter and 2.8% nodular goiter, where were been 144 female patients (80%) and 36 male patients (20%). Women have had predominance in the three groups that were analyzed pathologies, according to medical literature, an approximate incidence of 0.4 cases has existed per thousand women to year. A proportional relationship between clinical size of goiter and failure of therapy with 131I has been in diffuse goiter for the handling of hyperthyroidism. Likewise, male sex has been risk factor in the failure of such therapy. Multinodular goiter and nodular goiter have not had difference between the results according to sex and size of goiter. Most hyperthyroid patients with diffuse goiter, nodular and multinodular have received 131I as treatment, and previously this, they have received propylthiouracil; treatment outcome was unaffected. Treatment with 131I in hyperthyroid patients has managed to be effective for reduction in size of the thyroid gland in diffuse goiter, nodular goiter and multinodular

  18. Change in the direct cost of treatment for children and adolescents with hyperkinetic disorder in Germany over a period of four years

    Directory of Open Access Journals (Sweden)

    Rothenberger Aribert

    2009-01-01

    Full Text Available Abstract Background In many developed countries, the treatment of hyperkinetic disorder (or ADHD consumes a considerable amount of resources. The primary aim of this study was to determine change in the direct cost of treatment for children and adolescents with hyperkinetic disorder in Germany over time, and compare the cost with the cost of treatment for two physical disorders: epilepsy and asthma. Methods The German Federal Statistical Office provided data on the direct cost of treating hyperkinetic disorder, epilepsy and asthma in Germany for 2002, 2004, and 2006. The direct costs of treatment incurred by hyperkinetic disorder in these years were compared with those incurred by epilepsy and asthma. Results The total direct cost of treatment for the hyperkinetic disorder was € 177 million in 2002, € 234 million in 2004, and € 341 million in 2006. The largest proportion of the cost was incurred by the age group Conclusion The direct cost of treatment for hyperkinetic disorder in the age group

  19. Heavy Slow Resistance Versus Eccentric Training as Treatment for Achilles Tendinopathy

    DEFF Research Database (Denmark)

    Beyer, Rikke; Kongsgaard, Mads; Hougs Kjær, Birgitte;

    2015-01-01

    BACKGROUND: Previous studies have shown that eccentric training has a positive effect on Achilles tendinopathy, but few randomized controlled trials have compared it with other loading-based treatment regimens. PURPOSE: To evaluate the effectiveness of eccentric training (ECC) and heavy slow...... resistance training (HSR) among patients with midportion Achilles tendinopathy. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. METHODS: A total of 58 patients with chronic (>3 months) midportion Achilles tendinopathy were randomized to ECC or HSR for 12 weeks. Function and symptoms...... tendinopathy and that the latter tends to be associated with greater patient satisfaction after 12 weeks but not after 52 weeks....

  20. Anaerobic treatment of tequila vinasses under seasonal operating conditions: start-up, normal operation and restart-up after a long stop and starvation period.

    Science.gov (United States)

    Jáuregui-Jáuregui, J A; Méndez-Acosta, H O; González-Álvarez, V; Snell-Castro, R; Alcaraz-González, V; Godon, J J

    2014-09-01

    This study examines the performance of an anaerobic fixed-film bioreactor under seasonal operating conditions prevailing in medium and small size Tequila factories: start-up, normal operation and particularly, during the restart-up after a long stop and starvation period. The proposed start-up procedure attained a stable biofilm in a rather short period (28 days) despite unbalanced COD/N/P ratio and the use of non-acclimated inoculum. The bioreactor was restarted-up after being shut down for 6 months during which the inoculum starved. Even when biofilm detachment and bioreactor clogging were detected at the very beginning of restart-up, results show that the bioreactor performed better as higher COD removal and methane yield were attained. CE-SSCP and Q-PCR analyses, conducted on the biofilm prokaryotic communities for each operating condition, confirmed that the high COD removal results after the bioreactor clogging and the severe starvation period were mainly due to the stable archaeal and resilient bacterial populations.

  1. Clinical diagnosis and treatment of hysteromyoma and ovarian neoplasms in gestation period%妊娠期子宫肌瘤与卵巢肿瘤的临床诊治

    Institute of Scientific and Technical Information of China (English)

    高玉霞

    2016-01-01

    Hysteromyoma and ovarian neoplasms were common complication in gestation period.Ultrasound examination had great significance in the diagnosis of hysteromyoma and ovarian neoplasms in gestation period.This paper summarized the clinical diagnosis and treatment experience of hysteromyoma and ovarian neoplasms in gestation period.%子宫肌瘤与卵巢肿瘤是妊娠期常见并发症。超声检查对妊娠期子宫肌瘤与卵巢肿瘤的诊断意义重大。本文总结了妊娠期子宫肌瘤与卵巢肿瘤的临床诊治经验。

  2. Postnatal development and neoplastic disease pattern in NMRI-mice after combined treatment with ethylnitrosourea and X-irradiation on different days of the fetal period

    International Nuclear Information System (INIS)

    Mice were X-irradiated on either day 14, 15, or 16 of gestation with 1,0 Gy. This did not result in an increased tumor frequency in offspring until 12 months. Mice treated parallelly with ENU (45 mg/kg) on the same gestation days developed a significantly increased tumor frequency of the lungs and the liver in all treated groups, and of the ovaries after treatment on day 15 of gestation. This experiment was the first to show that ENU-treatment resulted in hemangiosarcomas of the subcutis at a low incidence. After combined treatment in the sequence X+ENU and an interval of 4 hours, increased tumor frequency was observed only in the offspring treated on gestation day 16. The diagnoses liver tumors and hemangiosarcomas were significantly augmented after X+ENU-treatment on day 15 and 16 and day 14 and 16, respectively. In the reverse sequence (ENU+X) the total tumor outcome was not significantly altered in comparison with the effects of ENU alone. However, detailed analysis also showed a synergistic action on liver tumor frequency on days 15 and 16. (orig./ECB)

  3. Clinical efficacy of recombinant human endostatin combined with FOLFOX4 in the treatment of later period episode patients of colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    Jie Zhang; Juan Wen; Yong-Gang Lu

    2015-01-01

    Objective:To observe the effects of recombinant human endostatin (recombinant human endostatin, Endostar) combined with FOLFOX4 regimen in the treatment of advanced node rectal cancer (colon and as cancer, CRC) of clinical efficacy and adverse reactions.Methods:253 patients with advanced colorectal cancer were randomly divided into observation group and control group, 126 cases in observation group and 127 cases in control group. The control group was treated with FOLFOX4, and the observation group was treated with recombinant human endostatin combined with FOLFOX4 regimen. To compare the short-term efficacy, quality of life and adverse reactions of the two groups.Results:the observation group and the control group total effective rate (ORR) were 60.32% and 43.31%, the difference was statistically significant; group two, disease control rate (DCR) were 81.75% and 70.87%, the difference was statistically significant; the first CRC patients, the observation group and the control group the PR rate was statistically significant; relapse patients, observation group and control group CR, PD, ORR and DCR rate were statistically significant;Conclusion: the use of recombinant human endostatin combined with FOLFOX4 regimen in the treatment of first-episode patients with advanced colorectal cancer, not obvious to improve curative effect; for patients with advanced relapsed, combination therapy is better than pure FOLFOX4 treatment; combination therapy in improving the quality of life and chemotherapy combined treatment had no significant difference; no serious adverse reaction, good safety, and has potential clinical application.

  4. [Interdisciplinary treatment concepts in chronic wounds].

    Science.gov (United States)

    Coerper, S; Kerber, A; Schäffer, M; Becker, H D

    1998-01-01

    Interdisciplinary concepts for the treatment of chronic wounds are mandatory because of the multifactorial reasons causing ulceration. This is a report on 6 years' experience at the wound care unit in Tübingen. Patients with chronic wounds (mainly diabetic, venous, and ischemic ulcers) were treated primarily as outpatients according to a standardised and interdisciplinary wound care protocol. Quality control was guaranteed by a standardised wound documentation system. The evaluation of this data demonstrates an overall healing rate of 69% within 52 weeks (mean). Before patients were referred to Tübingen, unsuccessful therapy was characterised by a mean wound duration of 35 weeks. The results presented justify this interdisciplinary wound care unit. PMID:9931704

  5. The science conceptions of chemical textbooks addressed to the high school, in treatment of chemical kinetics during the period from 1929 to 2004

    Directory of Open Access Journals (Sweden)

    Maria Eunice Ribeiro Marcondes

    2009-12-01

    Full Text Available This text is a part of the work that was developed based on the chemical kinetic theme and the target was how the scientific knowledge in this subject was used for high school textbooks, identifying the possible ideas about science related to these books. For that, based on the research developed by Níaz (1994 that used categories to represent the philosophical perspectives: the empirical/inductive and the rationalist, verifying which and how the concepts of science was inserted in the 20 Brazilians textbooks, edited in the period from 1929 to 2004.

  6. Comparison of the Treatment Period and Individual Properties of Patients with Hypertension Followed Up in the Two Cottage Hospitals from the Different Social Cultural Subgroups

    Directory of Open Access Journals (Sweden)

    Ejder Kardesoglu

    2008-08-01

    Full Text Available BACKGROUND: Hypertension is a major risk factor and also a component of metabolic syndrome. Its prevalence is closely related with social-cultural levels of a society. In this study we aimed to evaluate the blood pressure control in populations from lower (LSC and higher social-cultural (HSC subgroups of our society. METHOD: 53 and 36 hypertensive patients from societies with high and low social-cultural level, respectively. Systolic (SBP and diastolic blood pressures (DBP, duration of the treatment, education and income levels of patients were recorded and analyzed. Independent samples t test and Pearson’s Chi-Square test were used for statistical analyses. RESULTS: Age (51,08±5,6 vs 55,5±5,9 <0,05, SBP (128,8±7,8 vs 142,8±15,11 <0,05, and DBP (81,6±6,3 vs 88,01±6,9, <0,05 were found significantly increased in LSC. Blood pressure was not under control in LSC. The education and income level were statistically lower in the patients with high blood pressures. Also, it was noticed that the onset of hypertension treatment was significantly delayed in LSC when compared to the HSC. CONCLUSION: Control of blood pressure could not be achieved by the current hypertension drug treatment in the patients living in lower social-cultural subgroup of our society. Hypertension should be more effectively treated and monitored in the patients living in rural areas in order to reduce the prevalence of stroke and cardiovascular disease. It should be one of the health policies in preventive health care. [TAF Prev Med Bull 2008; 7(4.000: 333-338

  7. Impact of progesterone and estradiol treatment before the onset of the breeding period on reproductive performance of Bos indicus beef heifers.

    Science.gov (United States)

    Sá Filho, M F; Nasser, L F T; Penteado, L; Prestes, R; Marques, M O; Freitas, B G; Monteiro, B M; Ferreira, R M; Gimenes, L U; Baruselli, P S

    2015-09-01

    The present aimed to develop a hormonal therapy based on the insertion of a progesterone (P4) insert (PI) during 10 d plus an estradiol injection (E2) at PI removal before the onset of breeding of beef heifers. In Exp. 1, the plasma P4 profile of prepubertal heifers showed that the insertion of a PI or 24 d previously used P4 insert (UPI) sustained plasma P4 above 1 ng/mL for at least the first 7 d of the treatment. In Exp. 2 there was no positive effect of additional estradiol benzoate (EB) administered at the insertion of UPI on the proportion of heifers with a corpus luteum (CL/Treated) 30 d after UPI removal [UPI + EB = 85.3%(a) (n = 134); EB + UPI + EB = 80.8%(a) (n = 125)]; however, both were greater (P < 0.0001) than the Control group [60.3%(b) (n = 129)]. In Exp. 3, a positive effect (P=0.01) of UPI treatment and both E2 supplementations [EB and estradiol cypionate (EC); P = 0.10] at the UPI removal was observed on CL/Treated [Control = 42.5%(b) (n = 94); UPI = 58.5%(a) (n= 130); UPI + EB = 64.0%(a) (n = 128); UPI + EC = 67.2%(a) (n = 128)]. However, greater pregnancy per treated heifer (P/Treated) following artificial insemination (AI) upon estrus detection was achieved when EC was applied [Control = 20.2%(b); UPI = 29.2%(ab); UPI + EB = 26.6%(b); UPI + EC = 36.7%(a)]. In Exp. 4, the treatment prior to the timed AI (TAI) tended to improve pregnancy per TAI [P/AI; Control 43.6% (n = 298) vs. UPI+EC 51.9% (n = 342); P = 0.08], but increased P/Treated [26.5% vs. 43.3%; P < 0.001]. Thus, UPI + EC treatment were efficient in increasing the CL/Treated, tended to improve the P/AI and consequently enhanced P/Treated of zebu beef heifers.

  8. Incidence of modifiable cardiovascular risk factors and treatment of persons suffering from diabetes in the Bjelovar-Bilogora County during the period from 2001 to 2012

    Directory of Open Access Journals (Sweden)

    Magas Sasa

    2013-07-01

    Full Text Available The aim of this article is to present the incidence of modifiable cardiovascular risk factors and types of applied diabetes therapy in outpatients in the Center for Diabetes in the Bjelovar-Bilogora County during the period from 2001 to 2012.The study involved 4,408 outpatients whose e-records are maintained by the national register of diabetic persons CroDiab NET. 93% of patients had type 2 diabetes, while type 1 diabetes was recorded in only 3% of patients. Hypertension was present in 51% of patients with an upward trend in the last three years. The highest rate of dyslipidemia was 39% in 2004, with a downward trend at about 25% in the last 3 years. The frequency of patients with myocardial infarction was stable at around 10%, with the lowest value of 7.4% in 2010. The prevalence of patients with stroke also showed a downward trend from 14.9% to 7.4%. Only 10% of patients had body mass index (BMI 30 kg/m2. Good disease control was achieved by only 18% of patients, a further 18% of them had borderline disease control. Less than 1% of patients were treated only by changes in lifestyle and diet, while 43% of them were treated by oral medications. The combination of oral medications with insulin was applied in 38% of patients, and only 15% of patients were treated by insulin.To conclude, the influx of patients in the Center for Diabetes of the Bjelovar-Bilogora County is rising. The values of BMI, Hba1c levels and the incidence of hypertension and dyslipidemia are worrisome. A decrease in Hba1c which is a result of pronounced insulinization, or the introduction of new drugs such as DPP 4 inhibitors and GLP 1 analogues is encouraging

  9. 小城镇水污染治理设施建设期监管指标体系%Supervision Index System for Water Pollution Treatment Facilities during Construction Period in Small Towns

    Institute of Scientific and Technical Information of China (English)

    方俊华; 陈薇; 邱忠莉

    2012-01-01

    With the increasing concerns of water pollution in small towns,the built rate of water pollution treatment facilities has increased in recent years,but the supervision of the water pollution treatment facilities during the construction period is often absent. Based on the analysis of the current situation and existing problems for the supervision of the water pollution treatment facilities, the paper developed the regulatory index system during the construction process using the empirical method, then determined the index system according to the expert advice, and finally obtained the order of the index weight using the analytic hierarchy process. The results showed that it is indispensable to conduct supervision during the construction period. Meanwhile, the development of the regulatory index system provides a definite supervision object for the water pollution treatment facilities during the construction period. The index weight provides guidance for determination of the key supervision object during the construction period.%随着我国小城镇水污染问题日趋严重,小城镇水污染治理设施的建成率在逐年提高,而对小城镇水污染治理设施建设过程的监管却存在缺失的问题.通过分析水污染治理设施监管现状及存在的问题,首先采用经验法对建设期监管指标体系进行构建,并通过征询专家意见确定指标体系,最后应用层次分析法确定各指标的权重排序.结果表明,对建设期进行监管是必要的,同时,监管指标体系的构建,使得水污染治理设施建设期的监管对象得以明确;指标权重的确定,对于管理者明确建设期的重点监管对象,具有一定的指导作用.

  10. 地榆粉辨证施治Ⅲ期压疮的效果分析%A clinical analysis of treating bedsore duringⅢ period by differential treatment with Diyu Fen

    Institute of Scientific and Technical Information of China (English)

    周琳

    2016-01-01

    Objective: Clinical effects of Diyu Fen on bedsore duringⅢ period were investigated. Methods: 65 cases were randomly divided into two groups; the experimental group received Diyu Fen based on differential treatment; the control group was given conventional treatment. Clinical effcacy, healing time and cost of treatment in groups were compared. Results: In the experimental group, the cured was higher; the healing time was shorter; cost of treatment was lower; there were signiifcantly statistical differences (P<0.05). Conclusion: Treating bedsore duringⅢ period with Diyu Fen showed a good effect, was simple, inexpensive and worthy of promotion.%目的:探讨中药地榆粉辨证施治Ⅲ期压疮的临床疗效。方法:将65例Ⅲ期压疮患者随机分成两组,实验组采用地榆粉辨证施治;对照组采用常规治疗,比较两组在同一时间内的疗效、治愈时间及治疗费用。结果:实验组较对照组的治愈率高,治愈时间短,治疗费用低,两组比较差异有统计学意义(P<0.05)。结论:中药地榆粉辨证施治Ⅲ期压疮疗效好、方法简单、费用低,值得临床推广使用。

  11. 中医周期疗法用于人工流产术后的疗效观察%On the therapeutic effect of the traditional Chinese medicine periodic treatment after the artifitial abortion

    Institute of Scientific and Technical Information of China (English)

    于广宇; 张蔚莉

    2010-01-01

    Objective This paper aims at the therapeutic effect aft er the artifitial abortion by employing the TCM periodic treatment with respect to shortening the vaginal bleeding time and accelerating the uterine lining recovery. Methods Sampling 280 cases of artifitial abortion in early pregnancy, the author divides them at random the testing and control groups with each of the membership of 140 cases. Given the Nifuratel perorally same as the control group, the testing group is additionally under the TCM periodic treatment, that is, dosing Chinese medicine with the purpose of eliminating blood stasis,promoting tissue regeneration as well as invigorating the vital energy and nourishing the blood during the 1 to 3 days'postoperation period, giving Chinese medicine with a view of strenthening liver and kidney together with activating vital energy during the 4 to 14 days' postoperation period, instructing Chinese medicine in order to nourish the spleen and kidney as well as regulate Chong and Ren Vessels during the 15 to 25 days' postoperation period perorally and respectivelly. In contrast, the control group is given Xuefuzhuyu Capsules after the whole postoperation period. Results In terms of the time of vaginal bleeding, menstrual recovery and the regenerating condition of the uterine lining, the result (except for 3 cases in testing group and 2 cases in control group quiting the experiment) shows that after treatment (9 days after the abortion) the testing group achieves the effect superior to that of control group (P<0.01). Conclusion The conclusion is that the TCM periodic therapy is effective in the aspect of shortening the vaginal bleeding time, accelerating the uterine lining recovery and regulating the menstrual circle.%目的 观察中医周期疗法对人工流产术后阴道流血时间、子宫内膜修复、月经周期恢复的临床疗效.方法 280例早期妊娠要求行人工流产术的患者,随机分为治疗组、对照组各140例,两组术后均

  12. C linical observation of allylestrenol drug treatment of recurrent spontaneous abortion during different periods%烯丙雌醇在不同时期用药治疗复发性自然流产的效果观察

    Institute of Scientific and Technical Information of China (English)

    叶飞雪; 田玉华

    2014-01-01

    Objective To analyze the clinical efficacy of allylestrenol treatment of recurrent spontaneous abortion during differ -ent periods .Mte hods Clinal data of 172 patients with recurrent spontaneous abortion were analyzed and the patients were divided into control group ( n =43 ) and the observation group ( n =129 ) according to different dosages .The control group was given ogesterone treatment,and the observation group was divided into three subgroups ( n =43,each)according to different drug treatment periods and received allylestrenol treatment .The drug giving periods of subgroup A , B, and C were after ovulation ,two weeks after conception ,three weeks after conception respectively .Clinical efficacy and term delivery rates of each group were compared .Results The total effective rate of observation subgroup A was higher than that of subgroup C ( P <0.01)and term delivery rates of observation group were higher than that of control group( P <0.01),term delivery rate of observation subgroup A was higher than that of subgroup B ( P <0.05)and C( P <0.01).Conclusion The best periods of allylestrenol treatment of recurrent spontaneous abortion is after ovulation ,which can improve clinical treatment outcomes and the success rate of term delivery .%目的:分析烯丙雌醇在不同时期用药治疗复发性自然流产的临床效果。方法选择172例复发性自然流产患者为研究对象,根据用药不同分为两组。对照组43例给予黄体酮治疗,观察组129例给予烯丙雌醇治疗。观察组又根据用药时间不同分为3组,各43例。观察A组、观察B组及观察 C组用药时间分别为排卵后、受孕后2周及受孕后3周。比较各组治疗效果及足月分娩率。结果观察A组总有效率高于对照组和观察C组( P <0.01);观察组足月分娩率高于对照组( P<0.01),其中观察A组足月分娩率高于观察B组( P <0.05)和观察C组( P <0.01)。结论烯丙雌醇治

  13. Dynamics of nitrifying bacterial communities in the Seine river and estuary as affected by changes in the treatment of Paris wastewater : a comparison of 2001-2003 vs 2012-2013 periods

    Science.gov (United States)

    Aissa Grouz, Najla; Billen, Gilles; Garnier, Josette; Mercier, Benjamin; Martinez, Anun

    2014-05-01

    The major branch of the Seine river from the confluence with the Marne river to the entrance of the estuary is deeply affected by the release of wastewater from the huge Paris agglomeration. In the first years of 2000, the largest part of the effluents were still discharged at the Seine-Aval (Achères) treatment plant with only a standard, low residence time, activated sludge treatment, thus releasing a high ammonium load. NH4 concentration as high as 7 mgN/l were frequently observed downstream from Paris agglomeration. Cébron et al. (2003, 2005) and Garnier et al. 2007 described in details how this massive reduced nitrogen concentrations triggered the growth of nitrifying bacteria, already present in the upstream Seine and Marne rivers, but also brought in large amount by the effluents of the wastewater treatment plant themselves. The decrease of ammonium concentration was slow, however, and was only completed 200 km downstream, in the upper estuarine area, where it causes a severe oxygen deficiency. Since 2007, important changes occurred in the treatment of nitrogen in the Parisian wastewater purification plants. In 2007, the Seine-Aval plant treated up to 90% of the ammonium contained in wastewater through nitrification, and 30% of the total supply of nitrates is treated by denitrification. These modifications have of course favorably affected the water quality of the Seine river: ammonium concentrations are reduced by a factor of 5 and the area of oxygen depletion in the upstream estuary is no more observed. However, nitrites, still released in the effluents, are a matter of concern for the water quality of the Seine downstream from Paris. Using measurements of potential microbial activities carried out with the same experimental protocol for the 2000-2003 and 2012-2013 periods, we here examine and model the dynamics of ammonium oxidizing and nitrite oxidizing microbial populations before and after the implementation of nitrification treatment of Paris

  14. Dysmenorrhea: Painful Periods

    Science.gov (United States)

    ... Management Education & Events Advocacy For Patients About ACOG Dysmenorrhea: Painful Periods Home For Patients Search FAQs Dysmenorrhea: ... Dysmenorrhea: Painful Periods FAQ046, January 2015 PDF Format Dysmenorrhea: Painful Periods Gynecologic Problems What is dysmenorrhea? How ...

  15. Long-term safety and efficacy of dutasteride in the treatment of male patients with androgenetic alopecia.

    Science.gov (United States)

    Tsunemi, Yuichiro; Irisawa, Ryokichi; Yoshiie, Hiromu; Brotherton, Betsy; Ito, Hisahiro; Tsuboi, Ryoji; Kawashima, Makoto; Manyak, Michael

    2016-09-01

    Androgenetic alopecia is an androgen-induced pattern of progressive hair loss, which occurs in genetically predisposed people. This study aimed to determine long-term safety, tolerability and efficacy of dutasteride 0.5 mg, an inhibitor of 5-α-reductase, in Japanese male patients with androgenetic alopecia. This was a multicenter, open-label, prospective outpatient study (clinicaltrials.gov NCT01831791, GSK identifier ARI114264) in which patients took dutasteride 0.5 mg p.o. once daily for 52 weeks. Primary end-points included adverse event assessment, incidence of drug-related adverse event and premature discontinuations. Secondary end-points included hair growth, hair restoration and global improvement in hair. A total of 120 patients were enrolled, of whom 110 completed 52 weeks of treatment. Nasopharyngitis, erectile dysfunction and decreased libido were the most frequently reported adverse events and most adverse events were mild. Drug-related adverse events were reported with an incidence of 17%, none of which led to study withdrawal. Hair growth (mean target area hair count at week 52), hair restoration (mean target area hair width at week 52) and global appearance of hair (mean of the median score at week 52) improved from baseline during the study. As a potential future treatment option for male androgenetic alopecia, dutasteride 0.5 mg exhibited long-term safety, tolerability and efficacy within this study population. PMID:26893187

  16. Foot orthoses and physiotherapy in the treatment of patellofemoral pain syndrome: A randomised clinical trial

    Directory of Open Access Journals (Sweden)

    Darnell Ross

    2008-02-01

    Full Text Available Abstract Background Patellofemoral pain syndrome is a highly prevalent musculoskeletal overuse condition that has a significant impact on participation in daily and physical activities. A recent systematic review highlighted the lack of high quality evidence from randomised controlled trials for the conservative management of patellofemoral pain syndrome. Although foot orthoses are a commonly used intervention for patellofemoral pain syndrome, only two pilot studies with short term follow up have been conducted into their clinical efficacy. Methods/design A randomised single-blinded clinical trial will be conducted to investigate the clinical efficacy and cost effectiveness of foot orthoses in the management of patellofemoral pain syndrome. One hundred and seventy-six participants aged 18–40 with anterior or retropatellar knee pain of non-traumatic origin and at least six weeks duration will be recruited from the greater Brisbane area in Queensland, Australia through print, radio and television advertising. Suitable participants will be randomly allocated to receive either foot orthoses, flat insoles, physiotherapy or a combined intervention of foot orthoses and physiotherapy, and will attend six visits with a physiotherapist over a 6 week period. Outcome will be measured at 6, 12 and 52 weeks using primary outcome measures of usual and worst pain visual analogue scale, patient perceived treatment effect, perceived global effect, the Functional Index Questionnaire, and the Anterior Knee Pain Scale. Secondary outcome measures will include the Lower Extremity Functional Scale, McGill Pain Questionnaire, 36-Item Short-Form Health Survey, Hospital Anxiety and Depression Scale, Patient-Specific Functional Scale, Physical Activity Level in the Previous Week, pressure pain threshold and physical measures of step and squat tests. Cost-effectiveness analysis will be based on treatment effectiveness against resource usage recorded in treatment logs and

  17. 3种处理方式对冬枣货架期品质的影响%Effects of Different Treatments on Storage Quality of Dongzao Jujube Fruits during Shelf-life Period

    Institute of Scientific and Technical Information of China (English)

    武杰; 张引成; 李梅玲; 钱金

    2012-01-01

    In order to prolong the shelf life of Dongzao jujube fruits,the effects of three treatments were studied.Through the determination of respiration intensity,firmness,total soluble solids,vitamin C,ethylene release amount and ethanol production,effects of hot-water treatment,1-MCP and nano-package on the storage quality of Dongzao jujube fruits were studied during the shelf-life period.The results showed that all treatments could keep the storage quality of Dongzao jujube in some degree during the shelf-life period.The nano-package revealed the best effect on maintaining firmness,vitamin C content and fruit color,increasing total soluble solid amount,and inhibiting respiration rate,ethylene release amount and ethanol production.Therefore,nano-package could extend the shelf life of Dongzao jujube fruits up to 15 days.%以冬枣为试材,研究3种处理方式对其货架期品质的影响。通过测定冬枣的呼吸强度、硬度、总可溶性固形物、VC、乙烯释放量、乙醇积累等指标,研究热水浸泡、1-MCP熏蒸、纳米袋包装3种处理对冬枣果实的保鲜效果。结果表明:3种处理方法均不同程度保持了枣果货架期品质,其中纳米袋包装保鲜效果最佳,有效维持了冬枣果肉硬度和VC含量,延缓其色泽由绿到红的转变和总可溶性固形物上升,抑制了冬枣的呼吸强度及乙烯和乙醇的产生,货架期15d后,仍具有商品价值。

  18. 高压氧治疗各期糖尿病足间歇性跛行的疗效观察%Hyperbaric Oxygen Treatment of Diabetic Foot Every Period Curative Effect Observation of Intermittent Claudication

    Institute of Scientific and Technical Information of China (English)

    于桂贤

    2015-01-01

    Objective To observe patients with hyperbaric oxygen treatment of diabetic foot every period of intermittent claudication.Methods Select 26 patients with diabetic foot, no burst but plantar skin dark purple 0 grade diabetic foot 7 cases, the foot has burst 19 cases, observation on foot pain. ResultsAfter hyperbaric oxygen therapy group, on foot pain signiifcantly prolong time data to compare the two groups have statistical signiifcance (P< 0.05). Ankle brachial index (ABI) and local skin temperature is improved. Blood glucose significantly lower after treatment. Ulcer healing in 11 cases, remaining signiifcant reduction, 8 cases of ulcer surface can avoid amputation. Resting at night sex signiifcantly reduce pain, show the sleep quality improved.Conclusion Hyperbaric oxygen treatment of diabetic foot every period all can obtain satisfactory curative effect.%目的:观测高压氧治疗各期糖尿病足患者间歇性跛行的疗效。方法选取糖尿病足患者26例,无破溃但足趾皮肤暗紫色的0级糖尿病足7例,足部破溃19例,观察步行引起疼痛的时间。结果经过高压氧治疗组,步行引起疼痛的时间明显延长,两组数据比较有统计学意义,P<0.05。踝肱指数(ABI)及局部皮温有所改善。治疗后血糖下降明显。溃疡面愈合11例,剩余8例溃疡面明显缩小,可以避免截肢。夜间静息性疼痛明显减轻,表现为睡眠质量改善。结论高压氧治疗各期糖尿病足均可获得满意疗效。

  19. Assessment of Schistosoma mansoni induced intestinal inflammation by means of eosinophil cationic protein, eosinophil protein X and myeloperoxidase before and after treatment with praziquantel

    DEFF Research Database (Denmark)

    Reimert, Claus Michael; Tukahebwa, Edridah M.; Kabatereine, Narcis B.;

    2008-01-01

    Western Uganda where Schistosoma mansoni is endemic. Samples were collected before treatment and 5, 15, 20 and 52 weeks after treatment with praziquantel. Significantly increased levels of faecal ECP and EPX were found in S. mansoni infected individuals (n=155) compared to the levels found in stools from...... found between faecal egg counts and faecal concentrations of ECP and EPX. Treatment with praziquantel induced a significant decline in both ECP and EPX, but only a non-significant reduction in faecal MPO. Following reinfection and despite of very low infection intensities, the protein levels increased...... significantly reaching the pre-treatment level (ECP and EPX) or levels significantly higher than the pre-treatment levels (MPO). This response pattern may imply a rebound effect during reinfection following treatment and resolution of immune regulatory immunosuppressive mechanisms in function during the chronic...

  20. 不同时间骨质疏松性椎体压缩骨折的经皮椎体成形治疗☆%Percutaneous vertebroplasty for the treatment of osteoporotic vertebral compression fractures with different fracture periods

    Institute of Scientific and Technical Information of China (English)

    张其亮; 王峻; 林勇

    2013-01-01

      背景:近年来应用经皮椎体成形治疗老年骨质疏松性椎体压缩骨折的技术正在逐步开展,但其治疗不同骨折时间患者的疗效还存在争议。目的:对比经皮椎体成形治疗不同骨折时间骨质疏松性椎体压缩骨折的临床疗效。方法:回顾性分析随访资料完整的行经皮椎体成形治疗的骨质疏松性椎体压缩骨折病例91例(127节椎体)。按照受伤或疼痛发生到手术时间将病例分为3组:伤后3周内组、伤后3周-6个月组、伤后6个月以上组,比较3组经皮椎体成形治疗后疼痛缓解、日常生活能力恢复及椎体高度恢复情况。结果与结论:①3组治疗后疼痛明显缓解,且随着时间的延长疼痛逐渐减轻(P 伤后3周-6个月组>伤后6个月以上组(P 伤后3周-6个月组>伤后6个月以上组(P <0.01)。治疗前及治疗后3d各组椎体后缘高度差异无显著性意义。表明经皮椎体成形治疗对于伤后6个月以上陈旧性骨折的疗效较差。%BACKGROUND: In recent years, the technique of percutaneous vertebroplasty for the treatment of osteoporotic vertebral compression fractures is gradual y developed, but there is a controversy of the clinical effectiveness of percutaneous vertebroplasty for the treatment of osteoporotic vertebral compression fractures with different fracture periods. OBJECTIVE: To compare the effectiveness of percutaneous vertebroplasty for the treatment of osteoporotic vertebral compression fractures with different fracture periods METHODS: A retrospective study was conducted to review 91 cases receiving percutaneous vertebroplasty on 127 vertebral compression fractures. The patients were divided into three groups according to the time from fracture or pain occurrence to surgery: < 3 weeks group, 3 weeks-6 months group, ≥ 6 months group. The visual analogue scale, the Activity of Daily Living Scale and the height of vertebras were recorded and analyzed in the three

  1. Treatment of diabetic polyneuropathy with the neurotrophic peptide ORG 2766.

    Science.gov (United States)

    Valk, G D; Kappelle, A C; Tjon-A-Tsien, A M; Bravenboer, B; Bakker, K; Michels, R P; Groenhout, C M; Bertelsmann, F W

    1996-03-01

    The efficacy of the neurotrophic peptide ORG 2766 in diabetic patients with polyneuropathy was evaluated in a double-blind, placebo-controlled, multicentre trial. One hundred and twenty four patients were randomised in five groups to receive 0.1, 0.4, 2 or 5 mg ORG 2766 or placebo, once daily, administered subcutaneously 52 weeks. Thermal discrimination thresholds (TDT) and vibration perception thresholds (VPT), motor and sensory nerve conduction velocity, Hoffmann reflex, heart rate variation during deep breathing and heart rate response after standing up, neurological examination score and neuropathic symptom score were determined at baseline and after 17, 34 and 52 weeks of treatment. Of the nerve function indices studied, at week 52 the TDTwarmth of the hand in the ORG 2766 0.1, 0.4 and 5 mg groups and the TDTcold of the foot in the ORG 2766 0.1 and 0.4 mg groups significantly improved compared with placebo. Further significant improvement as compared with placebo was observed in the paraesthesia score at week 34 and week 52 in the ORG 2766 2 mg group. Only at week 34 had both the heartbeat variation during deep breathing and the VPT of the foot in the ORG 2766 0.1 mg group improved significantly, compared with placebo. No further statistically significant differences were observed at time for the other measures. No adverse reactions were observed. The only recorded drug-induced side effect was pain at the injection site. Taking all measures of efficacy into account, the statistically significant results observed did not show consistency within each measure. Therefore, it is concluded that ORG 2766, in contrast to earlier reports, is not effective in treating diabetic polyneuropathy. PMID:8936356

  2. Comparison of Buprenorphine Treatment for Opioid Dependence in Three Settings

    Science.gov (United States)

    Hillhouse, Maureen; Donovick, Roger; Cunningham-Rathner, Jerry; Charuvastra, Charlie; Torrington, Matthew; Esagoff, Asher E.; Ling, Walter

    2011-01-01

    Although use of buprenorphine in the treatment of opioid dependence is expected to continue to increase, little is known about the optimal setting for providing the medical and psychosocial care required with buprenorphine pharmacotherapy. OBJECTIVE This study compared buprenorphine therapy delivered in three distinct treatment settings: an opioid-treatment program (OTP) offering individual counseling; a group counseling program utilizing the manualized Matrix Model (MMM) of cognitive-behavioral treatment; and a private clinic setting mirroring standard medical management for buprenorphine treatment provided specifically at a psychiatrist’s private practice (PCS). METHOD Participants were inducted on buprenorphine and provided with treatment over a 52-week study duration. All participants were scheduled for weekly treatment visits for the first 6 study weeks, and two sites reduced treatment to monthly visits for dispensing of medication and psychosocial counseling. Outcomes include opioid use, participant retention in treatment, and treatment participation. RESULTS Participants presenting for treatment at the sites differed only by race/ethnicity, and opioid use did not differ by site. Retention differed by treatment site, with the number of participants who stayed in the study until the end of 20 weeks significantly associated with treatment site. The mean number of minutes spent in each individual counseling session also differed by site. Although no difference in opioid use by treatment site was found, results document a significant association between opioid use and buprenorphine dose. DISCUSSION These results show some differences by treatment site, although the similarity and relative ease in which the sites were able to recruit participants for treatment with buprenorphine, and minor implementation problems reported suggests the feasibility of treatment with buprenorphine across various treatment settings. CONCLUSION Similar rates of continued opioid use

  3. Cause Analysis and Treatment Countermeasures of elderly women with postmenopausal period vaginal bleeding%老年妇女绝经后阴道流血的原因分析与治疗对策探讨

    Institute of Scientific and Technical Information of China (English)

    段小青

    2012-01-01

      目的探讨分析老年妇女绝经后阴道流血的原因及治疗方案。方法回顾分析2007年1月-2011年12月我院接收的211例绝经后阴道流血及血性白带为主要症状的女性患者,排除因妊娠引起流血的病例,对其余患者进行妇科检查、经阴或腹部B超检查、TCT检查及宫腔镜下病理活检。观察分析所有患者的阴道流血的病因及病变程度。结果依据本组患者的各项检查及病理报告可分为:生殖器官炎症125例,子宫肌瘤18例,恶性肿瘤53例,其他15例。结论绝经早期阴道流血多数患者由生殖器官良性病变引起的,但随着绝经时间的延长,恶性程度越高,针对病因选取恰当的治疗方式才是行之有效的方案。%  Objective To analyze the causes and study the treatment programme of vaginal bleeding of elderly women in postmenopausal period. Methods On the basis of 211 elderly women patients in postmenopausal period with the main symptoms as vaginal bleeding or bloody whites from January 2007 to December 2011 in our hospital, excluding the cases of bleeding due to pregnancy, a series of gynaecological examination on the remaining patients are done, such as vaginal or abdominal B ultrasound examination, examination of TCT and hysteroscopic biopsy. The cause and severity of vaginal bleeding of all the patients are observed and analyzed. Results Based on the examination and pathological report of this group of patients, the results are as follows: 125 cases of genital inflammation, 18 cases of uterine fibroids, 53 cases of malignant tumor, 15 cases of other reasons. Conclusion Vaginal bleeding in the early postmenopausal period of the majority of patients is caused by benign lesions of genital mutilation, but as the menopause is prolonged over time, malignancy becomes worse and worse. Therefore, appropriate treatment programmes based on the analysis of the casues should be selected to deal with these diseases.

  4. The Periodic Pyramid

    Science.gov (United States)

    Hennigan, Jennifer N.; Grubbs, W. Tandy

    2013-01-01

    The chemical elements present in the modern periodic table are arranged in terms of atomic numbers and chemical periodicity. Periodicity arises from quantum mechanical limitations on how many electrons can occupy various shells and subshells of an atom. The shell model of the atom predicts that a maximum of 2, 8, 18, and 32 electrons can occupy…

  5. Can persons with a history of multiple addiction treatment episodes benefit from technology delivered behavior therapy? A moderating role of treatment history at baseline.

    Science.gov (United States)

    Kim, Sunny Jung; Marsch, Lisa A; Acosta, Michelle C; Guarino, Honoria; Aponte-Melendez, Yesenia

    2016-03-01

    A growing line of research has shown positive treatment outcomes from technology-based therapy for substance use disorders (SUDs). However, little is known about the effectiveness of technology-based SUD interventions for persons who already had numerous prior SUD treatments. We conducted a secondary analysis on a 12-month trial with patients (N=160) entering methadone maintenance treatment (MMT). Patients were randomly assigned to either standard MMT treatment or a model in which half of standard counseling sessions were replaced with a computer-based intervention, called Therapeutic Education System (standard+TES). Four treatment history factors at baseline, the number of lifetime SUD treatment episodes, detoxification episodes, and inpatient/outpatient treatment episodes were categorized into three levels based on their tertile points, and analyzed as moderators. Dependent variables were urine toxicology results for opioid and cocaine abstinence for 52-weeks. The standard+TES condition produced significantly better opioid abstinence than standard treatment for participants with 1) a moderate or high frequency of lifetime SUD treatment episodes, and 2) those with all three levels (low, moderate and high) of detoxification and inpatient/outpatient treatment episodes, pshistory, pstechnology-based behavioral therapy as part of treatment can be more effective than MMT alone, even among patients with a history of multiple addiction treatment episodes.

  6. Research of quality change for different treatment alfalfa bale during storage period%不同处理苜蓿草捆贮藏期内品质变化研究

    Institute of Scientific and Technical Information of China (English)

    荣磊; 格根图; 尹强; 贾玉山

    2013-01-01

      文章以国家牧草体系宁夏综合试验站试验地所种植的第二茬紫花苜蓿(金皇后)为试验材料,在其初花期刈割,并按照不同含水量、不同密度、不同CaO添加量进行打捆,贮藏360 d,定期取样。对不同处理草捆各贮藏期的样品进行霉菌数量和降解率测定,从而确定最适含水量、打捆密度、CaO添加量,为苜蓿草捆安全贮藏提供可靠的试验依据。通过试验数据分析得知,处理5(含水量为20%,打捆密度为150 kg/m3,CaO添加量为2%)贮藏期内霉菌数量最少,消化特性最好。%This paper take the second crop grown alfalfa (gold queen) of the national grass sys⁃tem comprehensive test station as the test material and cut in its initial flowering cradles, Ac⁃cording to the different water content, different density and different additive amount of CaO for bundling, and storaging 360 days, then regular sampling. By dynamic measuring the mould quan⁃tity and digestive rate of different processing bale during the storage period to determine the opti⁃mum water content, bundling density, additive amount of CaO for alfalfa bundle of safety storage provide reliable experimental basis. The mould number of treatment 5(moisture conntent is 20%, bundling density for 150 kg/m3, adding 2% CaO) during processing storage period is the least.

  7. 40 CFR 264.96 - Compliance period.

    Science.gov (United States)

    2010-07-01

    ....96 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Releases From Solid Waste Management Units § 264.96 Compliance period. (a) The Regional Administrator...

  8. 腹腔镜Ⅰ期胆囊和肾囊肿联合手术治疗的临床研究%Laparoscopic Ⅰ period galbladder and renal cyst of surgical treatment of joint clinical research

    Institute of Scientific and Technical Information of China (English)

    李帅; 钟震海

    2012-01-01

      Objective:Explore laparoscopic surgery treatment galbladder disease clinical feasibility of merger renal cyst and curative effect.Methods:Of 32 cases with cystic and calculous and kidney cyst al for Ⅰ period line laparoscopy, The first retroperitoneal into the road, Separation to the top, renal cyst drainage, And then change any galbladder resection operation field of clinical data were retrospectively analyzed. Results:32 cases average operation time 80 minutes, 3 cases of postoperative concurrent urinary retention, 2 cases with incision infection, The average time in five days, With the 5 to 12 months without complications and relapse, Patients returned to normal. Conclusion:As long as the strict control in laparoscopy application indications, under the premise of reasonable implementation Ⅰ laparoscopic surgical treatment of galbladder disease and renal cyst coexistence disease, Have good clinical application.%  目的探讨腹腔镜手术治疗胆囊疾病合并肾囊肿的临床可行性和疗效。方法对32例胆囊结石并肾囊肿均进行Ⅰ期行腹腔镜联合手术,先行经腹膜后入路,分离肾囊肿去顶、引流,而后改变术野再行胆囊切除治疗的临床资料进行回顾性分析。结果32例平均手术时间80分钟,3例术后并发尿潴留,2例切口感染,术后住院时间平均5天,随防3~24个月,无手术并发症及复发,患者恢复良好。结论只要在严格掌握腹腔镜联合手术应用指征的前提下,合理实施腹腔镜Ⅰ期手术治疗胆囊疾病并肾囊肿共存疾病,会有很好的临床发展前景和价值。

  9. The epidemic of smallpox in Guangdong Province and its prevention and treatment in the Republican period%民国时期广东的天花流行与防治

    Institute of Scientific and Technical Information of China (English)

    陈丽楠; 刘玲娣

    2014-01-01

    民国时期,广东几乎每年都有天花疫情发生.为了应对传染病,广东省建立了卫生行政及传染病防治机构,并自制牛痘疫苗;相关机构按周、月、年对疫情进行统计,并定期上报,以了解疫情进展.同时,还成立了传染病医院收容天花患者.港口检疫则将天花列为重点检查对象.为了推广牛痘接种,政府与社会合作,组织大规模的“种痘运动”,以儿童、学生和年轻人作为主要接种对象,并借助媒体积极宣传天花防治知识.%During the Republican period,the smallpox broke out in high frequency almost annually in Guangdong.In response to infectious diseases,the Guangdong government established the Health Administration and institutions for infectious disease's prevention and treatment,and prepared smallpox vaccine by themselves.In order to grasp the situation of the epidenmic,related institutions collected epidemic data weekly,monthly,and annually with the statistics reported regularly.Meanwhile,infectious diseasc hospital was established for smallpox patients.Harbor quarantine put smallpox as a key target of inspection.With the joint effort of the government and social organizations,massive "vaccination campaigns" was organized to promote vaccination,in which children,students and young people were the main subjects for inoculations.Prevention knowledge and anti-epidemic concept towards smallpox have been actively publicized and improved by media.

  10. Periodicity of chaotic solutions

    CERN Document Server

    Berezowski, Marek

    2016-01-01

    The scope of the paper is the analysis of the impact of flow reversal on the dynamics of cascades of reactors. Periodic and chaotic oscillations occur in the analyzed system. There is a dependence between the oscillation period of the state variable of the system without flow reversal and the recurrence period of windows of chaos in the steady-state diagram of the system with flow reversal.

  11. 不同处理方式对牛干巴贮藏期品质的影响%Effects of different treatments on the quality of dry-cured beef during storage period

    Institute of Scientific and Technical Information of China (English)

    胡凯弟; 甘芳瑗; 刘书亮; 王成; 何利; 陈姝娟

    2015-01-01

    .Low nitrite content was showed in thermal combined chemical treatment.AV and TVBN of that group were 1.50 mg/g and 52.5 mg/kg respectively,both of them were the lowest among all treatments.Sensory scores of thermal and thermal combined chemical group were very close,but microorganisms decreased faster.The color of ultra-high pressure treated group was not good,while the sterilization effect was desirable.The nitrite content,AV,TVBN and biomass of microorganism of control group were higher than all treated groups after 35 days.The number of bacteria and yeast of four treated groups decreased during storage.The nitrite content was less than 1.5 mg/kg which was much lower than the national standard.No peroxide value and fungus were detected throughout the storage period.The thermal combined with chemical-treated was the optimal treatment.

  12. Investigation of periodic multilayers

    CERN Document Server

    Bodnarchuck, V; Ignatovich, V; Veres, T; Yaradaykin, S

    2009-01-01

    Periodic multilayers of various periods were prepared according to an algorithm proposed by the authors. The reflectivity properties of these systems were investigated using neutron reflectometry.The obtained experimental results were compared with the theoretical expectations. In first approximation, the results proved the main features of the theoretical predictions. These promising results initiate further research of such systems.

  13. The Living Periodic Table

    Science.gov (United States)

    Nahlik, Mary Schrodt

    2005-01-01

    To help make the abstract world of chemistry more concrete eighth-grade students, the author has them create a living periodic table that can be displayed in the classroom or hallway. This display includes information about the elements arranged in the traditional periodic table format, but also includes visual real-world representations of the…

  14. Historically defined autobiographical periods

    DEFF Research Database (Denmark)

    Brown, Norman R.; Hansen, Tia G. B.; Lee, Peter J.;

    2012-01-01

    The chapter reviews a research programme that has demonstrated the existence of historically defined autobiographical periods and identified the conditions that bring them about. Data from four samples of World War II-generation adults show that historically defined autobiographical periods endure...

  15. 腰椎间盘突出症围手术期功能锻炼的护理%Nursing care of functional exercise during the perioperative period of surgial treatment for lumbar disc herniation

    Institute of Scientific and Technical Information of China (English)

    植智云; 叶焕兰; 邓雪娇; 梁前芝

    2013-01-01

    Objective To explore the effect of nursing care of functional exercise during the perioperative period of surgial treatment for lumbar disc herniation.Methods 986 patients with lumbar disc hemiation who had been hospitalized during the period of January 2001 to December 2011 were included in this study.The patients in January 2001 to December 2006 were assigned to a control group and those in January 2007 to December 2011 were assigned to a study group.The study group received prone position training,back muscle exercise,and training for cough,expectoration,and bed excretion to adapt postoperative lying in bed for a long time and avoid the occurrence of complications.After anesthesia,the patients received instruction for straight leg raising and flexion of hip and knee exercises.They performed functional excerise of low back muscle according todifferent surgical procedures.Results During a follow-up of 1 to 10 years,the rate of patients who developed nerve root adhesion,muscle atrophy in the affected lower limbs,or phlebothrombosis in the lower limbs,and who needed repeated surgery due to recurrence were lowered and length of hospital stay was shorter in the study group than in the control group.Conclusions For the patients with lumbar disc herniation,perioperative functional exercise can prevent postoperative adhesion of the nerve root,lower limb muscle disuse atrophy,and deep venous thrombosis of the lower extremities,and shorten length of hospital stay.%目的 探讨腰椎间盘突出症围手术期功能锻炼护理的效果.方法 选取我院2001年1月至2011年12月986例腰椎间盘突出症患者为研究对象,其中2001年1月至2006年12月的493例为对照组,2007年1月至2011年12月的493例为观察组.对照组采用常规护理方法,观察组在手术前进行俯卧位训练、腰背肌训练及咳嗽、咳痰、床上排泄训练,以适应术后长时间卧床,避免发生不良的并发症.手术麻醉过后指导进行直腿抬高和屈髋

  16. 温度变化和1-MCP处理对青椒贮藏品质的影响%Effects of Temperature Variation and 1-MCP Treatment on Quality of Green Pepper during Storage Period

    Institute of Scientific and Technical Information of China (English)

    侯田莹; 王福东; 寇文丽; 王博华; 郑淑芳

    2012-01-01

    以丰田新秀青椒为试材,模拟贮运过程中温度的变化,研究其对青椒品质的影响以及1-MCP处理在此过程中的保鲜效果.结果表明,贮运环境温度的变化容易导致青椒果实呼吸作用增强,失重率增加,可溶性固形物、可滴定酸、VC等营养成分消耗过快,硬度下降,造成衰败和腐烂;1-MCP处理可以显著抑制青椒由于温度变化而产生的代谢增强,从而较好地保持其可溶性固形物、可滴定酸、VC等营养成分,减少质量损失和腐败的发生,延缓果实的成熟和转红.10℃恒温结合1-MCP处理贮藏35d的青椒商品率可达90%以上;模拟青椒贮运条件,采用1μL/L浓度的1-MCP熏蒸24h,在10℃贮藏6d后,取出,盖上保温被在室温25℃条件下放置24h,再重新放入10℃冷库中贮藏28d时,青椒果实的商品率可达70%以上.%The green peppers of cultivar ' Fengtianxinxiu' were used as material to investigate the effect of temperature variation and dealing with 1 -MCP on quality of green pepper during storage period. The results showed that, temperature variation promoted the increase of respiration rate, weight loss rate, the consumption of some nutrition, such as soluble solids, titratable acidity, VC and so on, and the reduce of hardness, and might cause decay. However, 1-MCP treatment could significantly inhibit the increase of metabolism resulted from temperature, variation, and the nutrition was well maintained, reduced weight loss and delay, thereby, the maturity process from green peppers to red ones were delayed. The commodity rate of green pepper treated with 1-MCP at 10 ℃ storage temperature for 35 d was above 90%. The green peppers dealing with 1 |xL/L concentration of 1-MCP for 24 h, were taken out from the cold store after 6 days storage at 10 ℃ and then coated with polyurethane insulation for 24 h at room temperature (25 ℃), afterwards given back into the 10 ℃ cold store once again for 28 days storage , after

  17. Mean-periodic functions

    Directory of Open Access Journals (Sweden)

    Carlos A. Berenstein

    1980-01-01

    Full Text Available We show that any mean-periodic function f can be represented in terms of exponential-polynomial solutions of the same convolution equation f satisfies, i.e., u∗f=0(μ∈E′(ℝn. This extends to n-variables the work of L. Schwartz on mean-periodicity and also extends L. Ehrenpreis' work on partial differential equations with constant coefficients to arbitrary convolutors. We also answer a number of open questions about mean-periodic functions of one variable. The basic ingredient is our work on interpolation by entire functions in one and several complex variables.

  18. Jehovah's Witnesses' three periods

    Directory of Open Access Journals (Sweden)

    Åke V. Ström

    1975-01-01

    Full Text Available Among modern formations of religion, arisen within Christendom, there is no one that has changed its doctrine and attitude so much as Jehovah's Witnesses, so that the religious content in the three periods can be labelled as new, newer, the newest. Each period is connected with and dependent upon the three presidents Charles Taze Russel, born in 1852, president 1881-1916, Joseph Franklin Rutherford, born in 1869, president 1916-1942, and Nathan Homer Knorr, born in 1905, president from 1942. The purpose here is to clarify some important differences between the three periods.

  19. On some periodicity effects

    DEFF Research Database (Denmark)

    Sorokin, Sergey V.

    2015-01-01

    . In each case, special attention is paid to eigenfrequencies and eigenmodes of a single periodicity cell with appropriate boundary conditions. The influence of the amount of periodicity cells in a finite compound structure on its eigenfrequency spectrum is analyzed. Several features common...... for the considered models are found and discussed in the context of the existing knowledge on the subject. Another issue addressed in the lecture is an influence of the corrugation shape and amplitude on the broadness and location of the stop- and pass-bands in an infinite periodic structure. Explicit asymptotic...

  20. Single center experience over a 5-year period with sequential Transarterial Chemoembolization (TACE) in the treatment of Hepatocellular Carcinoma (HCC); Sequentielle transarterielle Chemoembolisation (TACE) des hepatozellulaeren Karzinoms (HCC) - Erfahrungsbericht eines einzelnen Zentrums ueber 5 Jahre

    Energy Technology Data Exchange (ETDEWEB)

    Herber, S.C.; Schneider, J.; Kummer, I.; Manzl, N.; Dueber, C.; Pitton, M.B. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Diagnostische und Interventionelle Radiologie; Otto, G.; Moench, C. [Mainz Univ. (Germany). Transplantationschirurgie und Chirurgie von Leber, Gallenwegen, Pankreas; Woerns, M.; Kanzler, S.; Schuchmann, M. [Mainz Univ. (Germany). I. Medizinische Klinik; Junginger, T. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Allgemein- und Abdominalchirurgie

    2007-03-15

    Purpose: To analyze the course of disease of patients treated with sequential TACE and to evaluate the dependent and independent prognostic factors for patient survival using the Cox Proportional Hazard Model. Materials and Methods: 94 patients palliatively treated with TACE. Patients were selected if they had been treated at least 3 times. The TACE procedure was carried out at 8-week intervals using a suspension consisting of a fixed dosage of Mitomycin C (10 mg) and 10 ml Lipiodol. Follow-up investigations included contrast-enhanced multislice CT before and after TACE and assessment of the laboratory test results (i. e., blood count, liver enzymes, and coagulation). Results: In 66.7 % of the patients, multifocal tumors were found. In 16.0 % of the patients, the tumor load represented more then 50 % of the liver volume. In 23.4 % of the cases, a portal vein thrombosis was found in the initial CT scan. The mean survival for the total cohort was 24.1 months (95 %-CI 20.1 - 28.2). During the investigation period, 72/94 of the patients died. The cumulative 1-year, 2-year, and 3-year survival rates are 71.6 %, 33.9 %, und 17.2 %, respectively. A median of 6.0 {+-} 3.1 (range 14, n total = 612 TACE) was performed in each patient. A total of 62.5 % patients died because of tumor progression whereas 18.1 % died due to progressive liver failure. Patients in whom the tumor responded to the TACE treatment and who did not develop ascites or those with Okuda stage I or unifocal tumor growth showed a survival benefit whereas the presence of portal vein thrombosis was associated with a significantly poor outcome (p < 0.05). The Child-Pugh stage was not statistically significant for the disease course; the occurrence of new tumor lesions had no influence with regard to 1-year and 2-year survival but had a significant influence on long-term survival (p < 0,05). Independent prognostic factors are (multivariate analysis; p < 0.05): number of TACE performed, tumor type (i. e

  1. The Peri Operation Period Nursing of Umbilical Single Port Laparoscopic Treatment of Diseases of the Urinary System%经脐单孔腹腔镜治疗泌尿系疾病的围手术期护理

    Institute of Scientific and Technical Information of China (English)

    夏婷婷

    2014-01-01

    Objective To investigate the peri operation period nursing of single hole laparoscopic urology patients. Methods From June to 2013 in our department in 2012 December 20 patients underwent transumbilical single hole laparoscopic operation treatment, the patients psychological nursing before operation, postoperative complications in special care, guidance for patients. Results 20 cases of operation were successful, no 1 cases were converted to laparoscopic or open operation, postoperative wound healing, patients' satisfaction to nursing work, no complications, no obvious scar of umbilical operation, cosmetic ef ect is good. Conclusion According to the nursing needs of patients with umbilical single hole laparoscopic urologic operation, formulation of peri operation nursing, to carry out holistic nursing and " and " and the nursing service mode, ensure the operation effect, prevent or detect complications, it is of significance for the patients received operation therapy and surgery after rehabilitation.%目的探讨单孔腹腔镜泌尿科患者的围手术期护理。方法选取我科2012年6月~2013年12月20例住院患者行经脐单孔腹腔镜手术治疗,术前对患者进行心理护理,术后针对常见并发症进行特殊护理,出院时对患者进行指导。结果20例手术均获成功,无1例中转腹腔镜或开放式手术,术后伤口愈合良好,患者对护理工作满意,无并发症发生,脐部无明显手术疤痕,美容效果良好。结论针对经脐单孔腹腔镜行泌尿系手术患者的护理需求,制定围手术期护理措施,有针对性地开展整体护理及"身心"并护的护理服务模式,确保手术效果,预防或及时发现并发症,对患者接受手术治疗和术后康复均有一定意义。

  2. Setting the Periodic Table.

    Science.gov (United States)

    Saturnelli, Annette

    1985-01-01

    Examines problems resulting from different forms of the periodic table, indicating that New York State schools use a form reflecting the International Union of Pure and Applied Chemistry's 1984 recommendations. Other formats used and reasons for standardization are discussed. (DH)

  3. The Periodic Table CD.

    Science.gov (United States)

    Banks, Alton J.; Holmes, Jon L.

    1995-01-01

    Describes the characteristics of the digitized version of The Periodic Table Videodisc. Provides details about the organization of information and access to the data via Macintosh and Windows computers. (DDR)

  4. Painful periods (dysmenorrhea) (image)

    Science.gov (United States)

    Primary dysmenorrhea is a normal cramping of the lower abdomen caused by hormone-induced uterine contractions before the period. Secondary dysmenorrhea may be caused by abnormal conditions such as ...

  5. Optimal periodic control

    CERN Document Server

    Colonius, Fritz

    1988-01-01

    This research monograph deals with optimal periodic control problems for systems governed by ordinary and functional differential equations of retarded type. Particular attention is given to the problem of local properness, i.e. whether system performance can be improved by introducing periodic motions. Using either Ekeland's Variational Principle or optimization theory in Banach spaces, necessary optimality conditions are proved. In particular, complete proofs of second-order conditions are included and the result is used for various versions of the optimal periodic control problem. Furthermore a scenario for local properness (related to Hopf bifurcation) is drawn up, giving hints as to where to look for optimal periodic solutions. The book provides mathematically rigorous proofs for results which are potentially of importance in chemical engineering and aerospace engineering.

  6. Establishing contract periods

    International Nuclear Information System (INIS)

    The lead time for executing the Adjustable Fixed-Commitment (AFC) contract and exceptions which may be considered are discussed. The initial delivery period is also discussed. Delays, deferrals, and schedule adjustment charges are finally considered

  7. Periodic solutions of periodically harvested lotka-volterra systems

    OpenAIRE

    Hausrath, Alan R.; Manasevich, Raul F.

    2012-01-01

    We study a Lotka-Volterra system with periodic harvesting, find sufficient conditions for the existence of periodic solutions with the same period, and, under certain conditions, count the number of such periodic solutions.

  8. Spontaneous periodic hypothermia.

    Science.gov (United States)

    Kloos, R T

    1995-09-01

    Spontaneous periodic hypothermia is a rare syndrome of recurrent, centrally mediated hypothermia without an identifiable systemic cause or brain lesion. Most patients defend a temporarily lowered temperature "set point" during episodes of hypothermia, despite manifesting many well-known systemic consequences of core temperature hypothermia. No case of death directly attributable to an episode of spontaneous periodic hypothermia has been reported, although many of the serious systemic effects of hypothermia have been documented in these cases, so it is not unlikely that death may occur. The syndrome's cause, and that of Shapiro syndrome, remains unknown. Pharmacologic trials to date have been only modestly successful. Anticonvulsant agents, clonidine, and cyproheptadine appear the most likely to succeed, with cyproheptadine being a reasonable first choice. Given that the term "spontaneous periodic hypothermia" describes a syndrome, and not a pathophysiologic mechanism, it is likely to encompass a common eventuality, arrived at via several different pathways. One can postulate mechanisms such as structural abnormalities, trauma, infection, irritation, and degeneration involving strategic locations which create a focus for epileptic or other periodic dysfunction whose scope involves the centers for thermoregulation. The existence of 2 distinct, oppositional thermoregulatory centers would allow for speculation of similar mechanisms accounting for cases of both periodic hypo- and hyperthermia (61). Postmortem data regarding the hypothalamic and surrounding areas from future cases of Shapiro syndrome and spontaneous periodic hypothermia would be of great interest. Further, more sensitive in vivo testing methods are clearly needed. The role of PET or single photon emission computed tomography (SPECT) with technetium 99m-labeled hexamethylpropylene amine oxime (Tc 99m HMPAO) performed acutely during an episode remains to be characterized (64, 103, 105). The term

  9. Periodically kicked turbulence

    Science.gov (United States)

    Lohse

    2000-10-01

    Periodically kicked turbulence is theoretically analyzed within a mean-field theory. For large enough kicking strength A and kicking frequency f the Reynolds number grows exponentially and then runs into some saturation. The saturation level Re(sat) can be calculated analytically; different regimes can be observed. For large enough Re we find Re(sat) approximately Af, but intermittency can modify this scaling law. We suggest an experimental realization of periodically kicked turbulence to study the different regimes we theoretically predict and thus to better understand the effect of forcing on fully developed turbulence. PMID:11089041

  10. Periodic paralysis complicating malaria.

    OpenAIRE

    Senanayake, N; Wimalawansa, S J

    1981-01-01

    Episodic muscular weakness, commonly associated with alterations of serum potassium, is the cardinal feature of periodic paralysis. The combination of transient hyperkalaemia and rigors occurring during febrile episodes of malaria is suggested as the underlying cause which precipitated the muscular paralysis. Three patients with malaria who developed a similar paralysis during the paroxysms of fever are described to illustrate this.

  11. Periodic Table of Students.

    Science.gov (United States)

    Johnson, Mike

    1998-01-01

    Presents an exercise in which an eighth-grade science teacher decorated the classroom with a periodic table of students. Student photographs were arranged according to similarities into vertical columns. Students were each assigned an atomic number according to their placement in the table. The table is then used to teach students about…

  12. Scheduling: Seven Period Day

    Science.gov (United States)

    Williamson, Ronald

    2010-01-01

    Driven by stable or declining financial resources many school districts are considering the costs and benefits of a seven-period day. While there is limited evidence that any particular scheduling model has a greater impact on student learning than any other, it is clear that the school schedule is a tool that can significantly impact teacher…

  13. Studies on the effectiveness of oral pellet vaccine in improving egg production and egg quality in desi chicken

    Directory of Open Access Journals (Sweden)

    T. Lurthu Reetha

    2016-08-01

    Full Text Available Aim: To study the effect of Newcastle disease (ND oral pellet vaccine in egg production and egg quality in desi chicken. Materials and Methods: The study was conducted at Veterinary University Training and Research Centre, Tiruchirapalli, Tamil Nadu. A total of 48-day-old desi chicks obtained from a private hatchery in Namakkal, Tamil Nadu, were maintained under cage system of rearing up to 52 weeks of age as per standard management practices. All the 48 chicks were divided into six groups having eight chicks in each group were subjected to different treatment regimes. All the birds were challenged at 52 weeks of age with 0.5 ml dose of 104.0 egg infectious dose 50 virulent ND field virus. 10 eggs from each group were randomly collected during the last 3 days of 8 weeks interval period from 28 to 52 weeks of age and were used to measure the egg quality parameters. The production performance of each group was assessed at 4 weeks interval period from 25 to 52 weeks of age. Results: In all the six treatment groups with respect to egg production, no significant difference (p≥0.05 was noticed from 25 to 52 weeks of age. Similarly, in egg weight, egg shape index and specific gravity, no significant difference (p≥0.05 was noticed from 28 to 52 weeks of age. Conclusion: From this study, it is concluded that the administration of ND oral pellet vaccine to desi chicken does not affect the egg production performance, egg weight, egg shape index, and specific gravity of egg.

  14. Complications of the surgical treatment early and tardy of supracondylar fractures of the humerus in children: a retrospective study of 111 patients treated at the Hospital Nacional de Ninos Carlos Saenz Herrera in the period January 2010 to January 2011

    International Nuclear Information System (INIS)

    Supracondylar fractures of the humerus up much of the emergency consultation of any pediatric orthopedic service, of them, Gartland III fractures are usually treated by closed reduction and percutaneous fixation with nails smooth. Often treatment has been delayed by factors such as the unavailability of an orthopedic specialist or local anesthesia or an operating room. At other times, the patient has come belatedly to consult. This retrospective study has analyzed whether a delay greater than 12 hours in the surgical treatment of supracondylar fractures of the humerus in children is associated with an increased risk of perioperative complications. Of 111 children who have been treated surgical in national children's hospital, underwent 59 surgeries before 12 hours from the trauma and 52 underwent surgery after 12 hours of trauma. The groups have developed without significant differences in terms of iatrogenic neurological injury, tract infection of the nails, vascular complications and compartment syndrome. Surgical time and hospital stay neither have had differences. In 2 cases of the tardy treatment group has been necessary to perform a opened reduction. As for the bad union, 9 cases (8%) have been of elbow varus radiological and clinical, of these 5 cases (4.5%) have occurred in the tardy treatment group and 4 cases (3,5) in the group early treatment. Findings of similar studies are confirmed in which the rate of perioperative complications is significantly unchanged if the surgical treatment is carried out before 12 hours or after 12 hours after the trauma. (author)

  15. Treatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss

    DEFF Research Database (Denmark)

    Iepsen, E W; Lundgren, J; Dirksen, C;

    2015-01-01

    BACKGROUND: Recent studies indicate that glucagon-like peptide (GLP)-1 inhibits appetite in part through regulation of soluble leptin receptors. Thus, during weight loss maintenance, GLP-1 receptor agonist (GLP-1RA) administration may inhibit weight loss-induced increases in soluble leptin...... receptors thereby preserving free leptin levels and preventing weight regain. METHODS: In a randomized controlled trial, 52 healthy obese individuals were, after a diet-induced 12% body weight loss, randomized to treatment with or without administration of the GLP-1RA liraglutide (1.2 mg per day). In case...... of weight gain, low-calorie diet products were allowed to replace up to two meals per day to achieve equal weight maintenance. Glucose tolerance and hormone responses were investigated before and after weight loss and after 52 weeks weight maintenance. Primary end points: increase in soluble leptin receptor...

  16. Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis

    DEFF Research Database (Denmark)

    Hetland, Merete Lund; Stengaard-Pedersen, Kristian; Junker, Peter;

    2006-01-01

    OBJECTIVE: To investigate whether disease control can be achieved in early active rheumatoid arthritis (RA) by treatment with methotrexate and intraarticular betamethasone, and whether the addition of cyclosporine to the regimen has any additional effect. METHODS: Patients (n = 160) were randomized...... to receive methotrexate 7.5 mg/week plus cyclosporine 2.5 mg/kg of body weight/day (combination therapy) or methotrexate plus placebo-cyclosporine (monotherapy). At weeks 0, 2, 4, 6, and 8 and every 4 weeks thereafter, betamethasone was injected into swollen joints (maximum 4 joints or 4 ml per visit......). Beginning at week 8, if synovitis was present, the methotrexate dosage was increased stepwise up to 20 mg/week, with a subsequent stepwise increase in the cyclosporine or placebo-cyclosporine dosage up to 4 mg/kg. RESULTS: At 52 weeks, 20% improvement according to the American College of Rheumatology...

  17. Combination treatment with metrotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis

    DEFF Research Database (Denmark)

    Hetland, Merete; Stengaard-Pedersen, Kristian; Junker, Peter;

    2006-01-01

    OBJECTIVE: To investigate whether disease control can be achieved in early active rheumatoid arthritis (RA) by treatment with methotrexate and intraarticular betamethasone, and whether the addition of cyclosporine to the regimen has any additional effect. METHODS: Patients (n = 160) were randomized...... to receive methotrexate 7.5 mg/week plus cyclosporine 2.5 mg/kg of body weight/day (combination therapy) or methotrexate plus placebo-cyclosporine (monotherapy). At weeks 0, 2, 4, 6, and 8 and every 4 weeks thereafter, betamethasone was injected into swollen joints (maximum 4 joints or 4 ml per visit......). Beginning at week 8, if synovitis was present, the methotrexate dosage was increased stepwise up to 20 mg/week, with a subsequent stepwise increase in the cyclosporine or placebo-cyclosporine dosage up to 4 mg/kg. RESULTS: At 52 weeks, 20% improvement according to the American College of Rheumatology...

  18. Cells anticipate periodic events

    Science.gov (United States)

    Nakagaki, Toshiyuki

    2009-03-01

    We show that an amoeboid organism can anticipate the timing of periodic events. The plasmodium of the true slime mold Physarum polycephalum moves rapidly under favourable conditions, but stops moving when transferred to less-favourable conditions. Plasmodia exposed to unfavourable conditions, presented in three consecutive pulses at constant intervals, reduced their locomotive speed in response to each episode. When subsequently subjected to favourable conditions, the plasmodia spontaneously reduced their locomotive speed at the time point when the next unfavourable episode would have occurred. This implied anticipation of impending environmental change. After this behaviour had been evoked several times, the locomotion of the plasmodia returned to normal; however, the anticipatory response could subsequently be induced by a single unfavourable pulse, implying recall of the memorized periodicity. We explored the mechanisms underlying these behaviours from a dynamical systems perspective. Our results hint at the cellular origins of primitive intelligence and imply that simple dynamics might be sufficient to explain its emergence.

  19. Scattering of periodic solitons

    Energy Technology Data Exchange (ETDEWEB)

    Cova, R.J. [Carleton University, School of Mathematics and Statistics, 1125 Colonel by Drive, Ottawa, Ontario K1S 5B6 (Canada); Zakrzewski, W.J. [University of Durham, Dept. of Mathematical Sciences, Durham DH1 3LE (United Kingdom)]. e-mail: rcova@math.carleton.ca

    2004-07-01

    Through numerical simulations we study N-soliton scattering (N = 3, 4) in the (2 + 1)-dimensional CP{sup 1} model with periodic boundary conditions. Solitons colliding from symmetrical configurations scatter at {pi}/ N, as observed in the usual model with standard boundary conditions. When the initial configurations are not symmetric the angles differ from {pi}/ N. We describe our observed patterns based on a properly formulated geodesic approximation. (Author) 11 refs., 10 figs.

  20. Periodic minimal surfaces

    Science.gov (United States)

    Mackay, Alan L.

    1985-04-01

    A minimal surface is one for which, like a soap film with the same pressure on each side, the mean curvature is zero and, thus, is one where the two principal curvatures are equal and opposite at every point. For every closed circuit in the surface, the area is a minimum. Schwarz1 and Neovius2 showed that elements of such surfaces could be put together to give surfaces periodic in three dimensions. These periodic minimal surfaces are geometrical invariants, as are the regular polyhedra, but the former are curved. Minimal surfaces are appropriate for the description of various structures where internal surfaces are prominent and seek to adopt a minimum area or a zero mean curvature subject to their topology; thus they merit more complete numerical characterization. There seem to be at least 18 such surfaces3, with various symmetries and topologies, related to the crystallographic space groups. Recently, glyceryl mono-oleate (GMO) was shown by Longley and McIntosh4 to take the shape of the F-surface. The structure postulated is shown here to be in good agreement with an analysis of the fundamental geometry of periodic minimal surfaces.

  1. Polysheroidal periodic functions

    International Nuclear Information System (INIS)

    Separation of variables in the Helmholtz N-dimensional (N≥4) equation in polyspheroidal coordinate systems leads to the necessity of solving equations going over into equations for polyspheroidal periodic functions used for solving the two-centre problem in quantum mechanics, the three-body problem with Coulomb interaction, etc. For these functions the expansions are derived in terms of the Jacobi polynomials and Bessel functions. Their basic properties, asymptotics are considered. The algorithm of their computer calculations is developed. The results of numerical calculations are given

  2. Periodic Mesoporous Organosilica Nanorice

    Directory of Open Access Journals (Sweden)

    Mohanty Paritosh

    2008-01-01

    Full Text Available Abstract A periodic mesoporous organosilica (PMO with nanorice morphology was successfully synthesized by a template assisted sol–gel method using a chain-type precursor. The PMO is composed of D and T sites in the ratio 1:2. The obtained mesoporous nanorice has a surface area of 753 m2 g−1, one-dimensional channels, and a narrow pore size distribution centered at 4.3 nm. The nanorice particles have a length of ca. 600 nm and width of ca. 200 nm.

  3. On occult period maps

    CERN Document Server

    Kudla, Stephen

    2012-01-01

    We consider the "occult" period maps into ball quotients which exist for the moduli spaces of cubic surfaces, cubic threefolds, non-hyperelliptic curves of genus three and four. These were constructed in the work of Allcock/Carlson/Toledo, Looijenga/Swierstra, and Kondo. We interpret these maps as morphisms into moduli spaces of polarized abelian varieties of Picard type, and show that these morphisms, whose initial construction is transcendental, are defined over the natural field of definition of the spaces involved. This paper is extracted from section 15 of our paper arXiv:0912.3758, and differs from it only in some points of exposition.

  4. The postanesthetic period. Complications.

    Science.gov (United States)

    Malamed, S F

    1987-01-01

    Postanesthetic complications can occur even in the best of circumstances. Proper preparation of the staff, aggressive monitoring of the recovering patient, and early recognition and management of the complications are essential if the outcome is to be successful. In reviewing postanesthetic complications, two factors are present in the overwhelming majority of situations--hypoxia and hypercarbia--often the direct result of inadequate monitoring during the postanesthetic period. The anesthetic procedure is not over once the anesthetic agents are discontinued. The skillful anesthetist is aware of the possibilities of postoperative complications and prevents problems by employing enhanced monitoring techniques during the recovery phase.

  5. Scattering of periodic solitons

    CERN Document Server

    Cova, R J

    2003-01-01

    With the help of numerical simulations we study N-soliton scattering (N=3,4) in the (2+1)-dimensional CP^1 model with periodic boundary conditions. When the solitons are scattered from symmetrical configurations the scattering angles observed agree with the earlier \\pi/N predictions based on the model on R_2 with standard boundary conditions. When the boundary conditions are not symmetric the angles are different from \\pi/N. We present an explanation of our observed patterns based on a properly formulated geodesic approximation.

  6. 不同时期脑卒中后抑郁的心理分析治疗及护理对策%Psychoanalysis treatment on post-stroke depression in different periods and the nursing strategies

    Institute of Scientific and Technical Information of China (English)

    邓华; 段勇

    2013-01-01

    Objective To study the psychoanalysis treatment on post-stroke depression in different periodsand the nursing strategies. Methods36 cases of patients with post-stroke depression were treated and nursed with the method of psychoanalysis, and prescribed with appropriate antidepressant treatment. To compare the changes of pre and post treatment with the scores of Hamilton Depression Rating Scale (HAMD). Results23 cases were cured (63.89%), 11 cases were getting better (30.56%), and 2 cases were ineffective (5.55%). The total effective rate is 94.44%. ConclusionThe method of proper psychoanalysis treatment and nursing, accompanying with appropriate antidepressant treatment , can notably relieve the depressive symptoms and improve the patients’ activities of daily living.%目的:探讨不同时期脑卒中后抑郁的心理分析治疗及护理对策方法。方法对36例脑卒中后抑郁的病人进行心理分析治疗和护理,并且适当给予抗抑郁药物治疗,治疗前后用汉密尔顿抑郁量表(HAMD)评分对比变化。结果治愈23例(63.89%),好转11例(30.56%),无效2例(5.55%),总有效率94.44%。结论对脑卒中后抑郁的病人进行正确的心理分析治疗及护理,并适当抗抑郁药物治疗,能明显改善患者的抑郁症状,提高患者日常生活活动能力。

  7. Periods and Superstring Amplitudes

    CERN Document Server

    Stieberger, S

    2016-01-01

    Scattering amplitudes which describe the interaction of physical states play an important role in determining physical observables. In string theory the physical states are given by vibrations of open and closed strings and their interactions are described (at the leading order in perturbation theory) by a world-sheet given by the topology of a disk or sphere, respectively. Formally, for scattering of N strings this leads to N-3-dimensional iterated real integrals along the compactified real axis or N-3-dimensional complex sphere integrals, respectively. As a consequence the physical observables are described by periods on M_{0,N} - the moduli space of Riemann spheres of N ordered marked points. The mathematical structure of these string amplitudes share many recent advances in arithmetic algebraic geometry and number theory like multiple zeta values, single-valued multiple zeta values, Drinfeld, Deligne associators, Hopf algebra and Lie algebra structures related to Grothendiecks Galois theory. We review the...

  8. RESULTS OF TREATMENT OF ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: DATA OF A RETROSPECTIVE, SINGLE-CENTER STUDY (IN-HOSPITAL PERIOD

    Directory of Open Access Journals (Sweden)

    D. B. Nemick

    2015-12-01

    Full Text Available Myocardial infarction significantly contributes to mortality rates in patients with chronic obstructive pulmonary disease (COPD. The influence of COPD on the course of acute ST-segment elevation myocardial infarction (STEMI is controversial.Aim. To evaluate characteristics of coronary artery lesions and cardiovascular complications in STEMI patients with and without COPD depending on a reperfusion treatment method during in-hospital stay.Material and methods. A total of 1112 cases of STEMI treatment within the first 6 hours of the symptoms onset were analyzed. All of these patients have undergone reperfusion treatment: primary percutaneous coronary intervention (PPCI or pharmacoinvasive strategy (PIS methods. All the patients were divided into two groups: patients without COPD (952 persons; 83.2% and those with COPD (160 patients; 16.8%. COPD impact on in-hospital course of STEMI was assessed.Results. The presence of COPD had no influence on STEMI in-hospital mortality. Mortality rates in patients with COPD (12 subjects; 7.5% and without COPD (83 subjects; 8.7% did not differ significantly (p=0.2. The study has demonstrated the significant influence of COPD on the patients’ baseline characteristics and treatment results, which can have an impact on long-term prognosis. According to our data COPD presence was associated with more severe coronary artery lesions in both PPCI and PIS subgroups (p<0.001. This has determined more frequent transmural myocardial damage in STEMI patients with COPD regardless of reperfusion strategy and time factor (79% in patients with COPD and 50% in those without one, p<0.001. The incidence of hemorrhagic complications also didn’t depend on COPD presence and remained low in all groups.Conclusion. At COPD presence STEMI was associated with more severe coronary artery lesions and increased frequency of transmural myocardial damage and residual stenosis after thrombolytic therapy. COPD did not lead to the

  9. 中老年慢性骨病患者围手术期心理治疗的应用进展%The application and progress of psychological treatment for elderly patients with chronic osteopathia in perioperative period

    Institute of Scientific and Technical Information of China (English)

    何明; 仲霄鹏; 朱锦宇; 朱庆生

    2012-01-01

    The operation can have significant impact on patients' mental states. Patients with degenerative bone and joint diseases tend to exhibit symptoms such as anxiety, depression, fear, insomnia and so on before the operation. At the same time, patients' personality traits may also cause mental problems that affect preoperative preparation and postoperative recovery. Previous literature has failed to provide consistent findings regarding this issue, which may be due to the differences in terms of the specific sampling, measures, and patients. Depression and anxiety can be influenced by the type of bone disease, social support, level of education, and prior surgical treatment. In order to understand patients' mental states, we need to apply measures derived from psychology, which complies with the majority of current studies on this topic. Other scholars also examined the mechanisms through which psychological problems developed. This study reviewed previous literature applying psychology to the surgical treatment of bone diseases. We discussed methods that may relieve patients' anxiety and depression, including medical and non-medical treatment. We found that medical treatment and non-medical treatment can be applied simultaneously, which can lead to better postoperative rehabilitation and recovery.%@@ 手术作为一种应激事件严重地影响着患者的精神状态.长期饱受骨病(如髋、膝退行性骨关节病或脊柱疾病)的中老年患者在面临手术时会出现不同程度的抑郁、焦虑、恐惧、失眠等症状.同时患者的人格特征以及慢性疾病对患者心理的影响,使得患者术前的心理问题更为突出,进而影响到术前准备和术后康复.本文就心理学在骨病外科治疗中的研究和应用做一综述.

  10. Tolvaptan and its potential in the treatment of hyponatremia

    Directory of Open Access Journals (Sweden)

    Y Howard Lien

    2008-10-01

    Full Text Available Megan B Dixon, Y Howard LienDepartment of Medicine, University of Arizona, Arizona Kidney Disease and Hypertension Center, Tucson, Arizona, USAAbstract: Tolvaptan is a selective arginine vasopressin (AVP V2 receptor blocker used to induce free water diuresis in the treatment of euvolemic or hypervolemic hyponatremia. Currently the orally active medication is in the final stages prior to approval by the FDA for outpatient therapy. It appears to be safe and effective at promoting aquaresis and raising serum sodium levels in both short- and long-term studies. Tolvaptan is also effective for treatment of congestive heart failure (CHF exacerbation, but whether there are long standing beneficial effects on CHF is still controversial. Prolonged use of tolvaptan leads to increased endogenous levels of AVP and perhaps over-stimulation of V1A receptors. Theoretically this activation could lead to increased afterload and cardiac myocyte fibrosis, causing progression of CHF. However, after 52 weeks of tolvaptan therapy there was no worsening of left ventricular dilatation. In addition, tolvaptan is metabolized by the CYP3A4 system; thus physicians should be aware of the potential for increased interactions with other medications. Tolvaptan is a breakthrough in the therapy of hyponatremia as it directly combats elevated AVP levels associated with the syndrome of inappropriate secretion of antidiuretic hormone, congestive heart failure, and cirrhosis of the liver.Keywords: hyponatremia, arginine vasopressin, vasopressin receptors, syndrome of inappropriate antidiuretic hormone, congestive heart failure, liver cirrhosis

  11. 妊娠期贫血病因及治疗效果的临床分析%The Clinical Analysis of Anemic Cause and Treatment Result in Gestational Period

    Institute of Scientific and Technical Information of China (English)

    陈丽华; 胡美霞; 彭群英; 管建粉; 王宁宁; 杨舟

    2011-01-01

    Objective To design corresponding interventional strategies according to causes of anemia in gestational period. Methods We performed perspective study. All of gravidas were divided into 2 groups. 299 gravidas in our study group were undergone ethological diagnosis and corresponding therapeutically strategies were designed. 304 gravidas in control group were administrated experienced therapy. Results of 2 groups were analyzed and compared. Results The incidences of iron deficient anemia and megaloblastic anemia in our study group were 95.32% and 3.34 % ,respectively. Anemic status prior to delivery was significantly better than that in control group(P<0. 01) ;The incidences of premature delivery, postpartum hemorrhage, fetal distress and gestational hypertension in study group were significantly lower than that in control group(P< 0.05 or P<0. 01). Conclusion Iron deficient anemia mainly occurs in gestational period. To ameliorate prognosis of pregnancy and fetal, we should design corresponding therapeutically strategies according to causes of anemia in gestational period.%目的 针对本地区妊娠期贫血的原因,制定具体的干预措施.方法 采用前瞻性研究,对299例研究组贫血孕妇进行病因诊断,制定具体的治疗方案,同期304例贫血孕妇为对照组,采取经验治疗.对2组孕妇治疗方案的治疗效果进行比较分析.结果 研究组中缺铁性贫血达95.32%,巨幼红细胞性贫血3.34%.分娩前贫血状况改善明显优于对照组(P<0.01),研究组在早产、产后出血、胎儿窘迫、妊娠高血压的发生率明显低于对照组(P<0.05或P<0.01).结论 妊娠期贫血主要是缺铁性贫血,针对贫血原因制定具体治疗方案可有效纠正贫血状况,显著改善母儿结局.

  12. Periodic and limit-periodic discrete Schr\\"odinger operators

    OpenAIRE

    Krueger, Helge

    2011-01-01

    The theory of discrete periodic and limit-periodic Schr\\"odinger operators is developed. In particular, the Floquet--Bloch decomposition is discussed. Furthermore, it is shown that an arbitrarily small potential can add a gap for even periods. In dimension two, it is shown that for coprime periods small potential terms don't add gaps thus proving a Bethe--Sommerfeld type statement. Furthermore limit-periodic potentials whose spectrum is an interval are constructed.

  13. [THE ROLE OF MOTHER'S MILK AND BREAST FEEDING. MEDICAL PROBLEMS DURING THE LACTATION PERIOD LACTOBACILUS FERMENTUM--A NEW APPROACH TOWARDS THE PREVENTION AND THE TREATMENT OF ACUTE AND SUBACUTE MASTITIS].

    Science.gov (United States)

    Popova, B; Mitev, D; Nikolov, A

    2016-01-01

    Breast feeding provides a lot of short and long-term benefits for the mother and the baby. It prevents the baby of gastrointestinal, urinary and respiratory infections, atopical conditions and assures long-term protection of cardiovascular and metabolic diseases. The breast feeding decreases the risk for the mother of ovary and breast carcinoma and creates a positive emotional bond between the mother and the baby Mother's milk is a species specific; its content is relatively stable regardless of mother's age race, way and place of living. Mother's milk is not sterile. There is a 10 year international trial held in Spanish and Finnish universities. It has identified and count all microorganisms in mother's milk (more than 700) and proved that their content and quantity varies according the age of the baby. Mother's milk is a source of lactobacillus for baby's intestines and most of them have probiotic potential. Lactobacillus fermentum Lc40 (hereditum) is isolated from mother's milk. It has a good viability in gastrointestinal system, high level of adhesion to intestinal epithelium cells, produces glutation--strong antioxidant, good antibacterial activity to entero-pathogens and potential of increasing the immunologic response. Clinical trials reveal that Lactobacillus fermentum plays important role to microflora balance of mother's milk in mastitis during lactation. Many trials estimating the efficiency of lactobacillus fermentum in prevention and treatment of acute and subacute mastitis have been carried out. The results of them open a new door in front of us in the treatment of these conditions--treatment with probiotics instead of antibiotics. PMID:27514147

  14. The Lueneburg model - experience from a one-year operating period of the mechanic-biological waste pre-treatment plant; Modell Lueneburg - Erfahrungen aus einem Jahr Betrieb der MBV-Anlage

    Energy Technology Data Exchange (ETDEWEB)

    Tegtmeyer, E. [Gesellschaft fuer Abfallwirtschaft Lueneburg mbH, Bardowick (Germany)

    1997-12-31

    The Lueneburg plant is one of three demonstration plants for mechanic-biological pre-treatment of residual waste which receive considerable grants from the state of Niedersachsen. Whereas the other two plants, the one at Bassum (district of Diepholz) and the one at Wiefels (district of Friesland), are currently under construction, the Lueneburg plant has been officially inaugurated already in December 1995 and has since been in operation. (orig./SR) [Deutsch] Die Lueneburger Anlage ist eine von drei Demonstrationsanlagen zur mechanisch-biologischen Vorbehandlung von Restabfaellen, die durch das Land Niedersachsen in erheblichem Umfang anteilig gefoerdert werden. Waehrend die beiden anderen Anlagen in Bassum (Landkreis Diepholz) und Wiefels (Landkreis Friesland) sich zur Zeit in der Errichtungsphase befinden, ist die MBV-Anlage Lueneburg bereits im Dezember 1995 offiziell eingeweiht worden und verfuegt damit mittlerweile ueber eine etwa einjaehrige Betriebserfahrung. (orig./SR)

  15. A 4-day critical period in corticosteroids treatment for traumatic optic neuropathy%皮质类固醇治疗外伤性视神经病变的四天关键时期

    Institute of Scientific and Technical Information of China (English)

    Soon Lek Yap; Angeline Diong Ching Nga; Nadir Ah Mohamed AH; Visvaraj'a Subrayan

    2008-01-01

    目的:评估静脉注射甲基强的松龙(IVMP)对外伤性视神经病变患者的疗效.方法:回顾性分析2000-01至2007-06我院收治的16例外伤性视神经病变(TON)患者的临床资料.1g甲基强的松龙分3d静脉应用,然后口服泼尼松龙11d,并逐渐减量.记录从损伤开始到治疗开始的时间.视力变化是本研究结果的主要功能评价指标.在入院时,治疗后1,2,3d;1wk和1mo时,分别记录最佳矫正视力(BCVA).结果:共有16例患者纳入本研究,平均年龄为30岁,其中男性14例、女性2例.引起TON的主要原因有摩托车事故(占69%),打架斗殴(占19%)和体育运动(占12%).所有患者都表现有相对传入性瞳孔障碍.在损伤后4d内开始静脉注射甲基强的松龙,采用Snellen视力表检查视力,绝大部分(56%)患者视力提高超过3行或大于等于0.5(6/12).在损伤后5d以上才开始用类固醇治疗,视力则没有任何进步.结论:治疗TON,静脉注射中等到大剂量甲基强的松龙仍将起到重要作用.静脉注射甲基强的松龙治疗TON可能存在伤后4d的关键时期,超过了这个时期,该治疗可能就毫无效果.但还需要有更多的研究来为我们提供有明显统计学意义的数据.%·AIM: To evaluate the outcome of intravenous methyl-prednisolone ( IVMP) in patients with traumatic optic neuropathy (TON).·METHODS: Clinical data of 16 patients with TON who were admitted to our hospital from January 2000 to June 2006 were retrospectively analyzed. 1g of IVMP in divided doses for 3 days followed by a reducing dose of oral prednisolone for 11 days were given. Timing between the onset of injury and the initiation of treatment was noted.A change in visual acuity is the primary functional outcome measure of this study. Best corrected visual acuity (BCVA) was recorded at admission, on day 1, day 2, day 3, 1 week and 1 month after treatment.·RESULTS; Sixteen patients were included in this study with a mean age of 30. Fourteen of

  16. Photolysis of Periodate and Periodic Acid in Aqueous Solution

    DEFF Research Database (Denmark)

    Sehested, Knud; Kläning, U. K.

    1978-01-01

    The photochemistry of periodate and periodic acid in aqueous solution was studied (i) by quantum yield measurements at low light intensity (ii) by flash photolysis, and (iii) by photolysis of glassy samples at 77 K. The photochemical studies were supplemented with pulse radiolysis studies...... of aqueous periodate solutions and with kinetic studies using stopped-flow technique. In strongly alkaline solution the photodecomposition of periodate proceeds via formation of O– and IVI. At pH

  17. El tratamiento mediático del dopaje en el periodo de transición democrática = Media treatment of doping during the democratic transition period

    Directory of Open Access Journals (Sweden)

    Noemí García Arjona

    2013-04-01

    Full Text Available La actualidad deportiva no deja de mostrarnos el enorme impacto mediático del dopaje, y la importancia de cómo el deportista objeto de sospecha aparece expuesto, ya sea para alabarlo o para juzgarlo. Sin embargo, esta relación ya tiene sus precedentes en la historia reciente, siendo el periodo del tardofranquismo y la transición democrática clave para la sociedad y para el deporte en el contexto español, y que tomamos como referencia. A través de la prensa especializada (Marca, Mundo Deportivo, As, se va a analizar el papel histórico que los medios deportivos en España han desempeñado con relación al atleta sospechoso de dopaje: unas veces bajo la “ley del silencio”, otras bajo una aparente ingenuidad, y en ocasiones comprensivos con las vicisitudes del deportista.----------------------------------------------------------------------------Current sport situation continues to show the enormous media impact of doping, and the importance of how the athlete under suspicion appears exposed, either to praise or to judge. However, this relationship has its precedents in recent history, having as reference the period of the last years of Franco’s regime and early times of democratic transition, due to its importance for the society as well as for sport in the Spanish context. Through the specialized press (Marca, Mundo Deportivo, As, we will analyze the historical role played sports media in Spain related to the athlete suspected of doping: sometimes under the “law of silence”, sometimes under an apparent naivety, and in other cases, comprehensive to the difficulties of the athlete.

  18. 妊娠期输尿管结石并发顽固性肾绞痛的微创治疗%Minimally invasive treatment of ureteral calculi with period of refractory renal colic during pregnancy

    Institute of Scientific and Technical Information of China (English)

    卢文武; 张建育; 刘榕臻; 李毅宁; 王明镑; 洪传芳

    2014-01-01

    Objective To evaluate the safety and efifcacy of treatment of refractory renal colic due to ureteric calculi during pregnancy. Methods In our hospital in September 2009 to June 2014, clinical data of 18 pregnant women with refractory renal colic due to ureteric calculi in my hospital were collected and retrospectively analyzed.13 cases received intra-ureteral double-J cannula alone. 5 cases received intra-ureteral double-J cannula after ureteroscopic pneumatic lithotripsy. Results Renal colic was relieved in 18 cases after operation. All the pregnant women had normal delivery and gave birth to healthy babies. Conclusion For pregnant women with refractory renal colic due to ureteric calculi, intra-ureteral cannula alone and intra-ureteral double-J cannula after ureteroscopic pneumatic lithotripsy treatment are safe and effective.%目的:探讨妊娠期输尿管结石并发顽固性肾绞痛的微创治疗的安全性及疗效。方法对我院2009年9月~2014年6月,共18例妊娠期输尿管结石并发顽固性肾绞痛的患者,进行回顾性分析。13例患者采用输尿管置管术,5例患者采用输尿管镜气压弹道碎石+输尿管置管术治疗。结果18例患者肾绞痛都得到有效缓解,均顺利生产,婴儿健康。结论对妊娠期输尿管结石并发顽固性肾绞痛患者采用输尿管置管术、输尿管镜气压弹道碎石+输尿管置管术等微创外科治疗技术,是安全有效的。

  19. Observation of clinical effect of routine atomization combined massage treatment of children bronchial asthma at chronic persistent period%常规雾化联合推拿疗法治疗小儿支气管哮喘慢性持续期临床效果观察

    Institute of Scientific and Technical Information of China (English)

    张宝珍; 裴竹英

    2015-01-01

    ObjectiveTo study and analyze the clinical treatment effect of routine atomization combined massage in the treatment of children bronchial asthma at chronic persistent period.Methods 100 children patients with chronic persistent asthmatics, who were received and treated in clinic of our hospital from October 2012 to November 2014, were selected and were divided into treatment group and control group according to different treatment methods, with 50 cases in each group. The control group was treated with routine atomization, while the treatment group was treat with routine atomization combined massage, the treatment cycle were all 8 weeks. To observe and compare the effective rate of clinical treatment of children patients between the two groups, to analyze the change levels of intracorporal inflammatory factors of children patients by peripheral blood. Results After 8 weeks treatment, the effective rate of clinical treatment in treatment group was better than which in control group(P<0.05), the change levels of intracorporal inflammatory factors of children patients of IL-17, IL-33, IL-6 in treatment group were statistical significance compared with which in control group(P<0.05).Conclusion Routine atomization combined with massage in the treatment of children bronchial asthma at chronic persistent period is effective, could improve children immunological function meanwhile to treat the symptoms of asthma, has higher popularization and application value in clinical treatment.%目的:研究分析常规雾化联合推拿疗法对小儿支气管哮喘慢性持续期的临床治疗效果。方法选择2012年10月~2014年11月期间我院门诊收治入院的100例慢性持续期哮喘患儿,按照治疗方法不同分为治疗组和对照组,每组患儿50例。对照组运用常规雾化疗法进行治疗,治疗组运用常规雾化联合推拿疗法进行治疗,治疗周期均为8周。观察比较两组患儿临床治疗有效

  20. The redoubtable ecological periodic table

    Science.gov (United States)

    Ecological periodic tables are repositories of reliable information on quantitative, predictably recurring (periodic) habitat–community patterns and their uncertainty, scaling and transferability. Their reliability derives from their grounding in sound ecological principle...

  1. A new characterization of periodic oscillations in periodic difference equations

    Energy Technology Data Exchange (ETDEWEB)

    Al-Salman, Ahmad [Department of Mathematics and Statistics, Sultan Qaboos University, P.O. Box 36, PC 123, Al-Khod (Oman); AlSharawi, Ziyad, E-mail: alsha1zm@alsharawi.info [Department of Mathematics and Statistics, Sultan Qaboos University, P.O. Box 36, PC 123, Al-Khod (Oman)

    2011-11-15

    Highlights: > A characterization of periodic solutions of periodic difference equations is given. > The periods are classified as multiples and non-multiples of the phase-period. > Non-multiples of the phase-period depend on the intersections between the maps. > A refinement of Sharkovsky's theorem for periodic difference equations is given. - Abstract: In this paper, we characterize periodic solutions of p-periodic difference equations. We classify the periods into multiples of p and nonmultiples of p. We show that the elements of the set of multiples of p follow the well-known Sharkovsky's ordering multiplied by p. On the other hand, we show that the elements of the set {Gamma}{sub p} of nonmultiples of p are independent in their existence. Moreover, we show the existence of a p-periodic difference equation with infinite {Gamma}{sub p}-set in which the maps are defined on a compact domain and agree exactly on a countable set. Based on the proposed classification, we give a refinement of Sharkovsky's theorem for periodic difference equations.

  2. Periods and elementary real numbers

    OpenAIRE

    Yoshinaga, Masahiko

    2008-01-01

    The periods, introduced by Kontsevich and Zagier, form a class of complex numbers which contains all algebraic numbers and several transcendental quantities. Little has been known about qualitative properties of periods. In this paper, we compare the periods with hierarchy of real numbers induced from computational complexities. In particular we prove that periods can be effectively approximated by elementary rational Cauchy sequences. As an application, we exhibit a computable real number wh...

  3. 丁丙诺啡舌下含片与美沙酮用于海洛因依赖门诊稽延期治疗的对照研究%Control study of buprenorphine sublingual tablets and methadone for heroin addicts on out patients treatment during recovery period

    Institute of Scientific and Technical Information of China (English)

    牛光胜; 杜万君; 王玉明; 郑杰

    2011-01-01

    目的 观察丁丙诺啡舌下含片与美沙酮用于海洛因依赖者稽延期治疗的价值。方法 对完成脱毒治疗患者,依先后次序交叉纳入观察组与对照组,分别给予丁丙诺啡舌下含片和美沙酮治疗6个月,观察操守时间,并于入组前后做焦虑量表评分。结果 丁丙诺啡舌下含片组比美沙酮组的操守时间长(P<0.01),焦虑评分低(P<0.05)。结论 丁丙诺啡舌下含片于海洛因依赖门诊稽延期治疗能更好地缓解焦虑情绪并延长操守时间。%Objective To observe the effect of buprenorphine sublingual tablets (Bup) and methadone for heroin addicts on out patients treatment during recovery period. Methods Heroin addicts who completed acute drug detoxification treatment were assigned in the order of cross to the observation group and control group. The observation group and the control group were treated with Bup and methadone, respectively for six months. Both groups were observed on the time of keeping heroin abstinence during the treatment and were assessed with Anxiety Scale before and after Bup or methadone treatment. Results Bup group kept abstinence from heroin longer than methadone group ( P <0.01 ) ,and had lower anxiety scores( P <0.05). Conclusion Bupernorphine sublingual tablets used for out patients at recovery period could better alleviate heroin addicts' anxiety and prolong their abstinence time.

  4. Periodic waves in nonlinear metamaterials

    International Nuclear Information System (INIS)

    Periodic waves are presented in this Letter. With symbolic computation, equations for monochromatic waves are studied, and analytic periodic waves are obtained. Factors affecting properties of periodic waves are analyzed. Nonlinear metamaterials, with the continuous distribution of the dielectric permittivity obtained, are different from the ones with the discrete distribution. -- Highlights: ► Equations for the monochromatic waves in transverse magnetic polarization have been studied. ► Analytic periodic waves for the equations have been obtained. ► Periodic waves are theoretically presented and studied in the nonlinear metamaterials.

  5. 两种术式治疗婴幼儿期舌系带过短的效果比较%Comparison of the Effects of Two Surgical Treatments on Short Lingual Frenulum in Infantile Period

    Institute of Scientific and Technical Information of China (English)

    于在湖; 胡青芳; 杜衍晓

    2014-01-01

    目的:在临床上比较舌系带剪断术和舌系带矫正术治疗舌系带过短患儿的效果。方法选择的研究对象为在2007年2月-2014年2月期间,该院收治的200例舌系带过短的患儿,将这200例患儿随机分为给予舌系带矫正术治疗的对照组和给予舌系带剪断术实验组,每组100例,然后将对照组患儿与实验组患儿术后出血、感染以及发音等情况进行比较。结果实验组患儿在术后出现出血、感染发生率明显低于对照组患儿,组间差异有统计学意义(P0.05)。结论两种手术均可应用于舌系带过短的治疗,应用舌系带剪断术治疗舌系带过短的患儿,在术后出血、感染以及肿胀等方面的发生率上低于舌系带矫正术,但在患儿发音的改善上弱于上舌系带矫正术。%Objective To compare the clinical effect of treating children with too short tongue tie with tongue tie cut surgery and surgical correction of lingual frenum. Methods 200 children with too short lingual frenulum admitted in our hospital from February 2007 to February 2014 were selected as the subjects and randomly divided into two groups, the control group was treated by surgi-cal correction of lingual frenum, and the experimental group was treated by tongue tie cut surgery. Both groups had 100 children. And then the children in the control group and the experimental group were compared by postoperative bleeding, infection, and pronunciation and so on. Results The incidence of postoperative bleeding and infection of the experimental group was significantly lower than that of the control group, the difference between the groups was statistically significant (P0.05). Conclusion Both surgeries can be applied to the treatment of short tongue tie. Compared with surgical correc-tion of lingual frenum, children treated by tongue tie cut surgery have lower incidence of postoperative bleeding, infection and swelling, but weaker improvement of

  6. The B-VITAGE trial: A randomized trial of homocysteine lowering treatment of depression in later life

    Directory of Open Access Journals (Sweden)

    van Bockxmeer Frank

    2010-01-01

    Full Text Available Abstract Background Depression is a leading cause of disability worldwide and depressive symptoms are common in later life. Observational evidence suggests that depression is more prevalent among people with high plasma homocysteine (tHcy, but the results of randomized trials to date have been unable to show that lowering tHcy through the supplementation of vitamins B6, B12 and folate benefits depressive symptoms. We designed the B-VITAGE trial to determine whether adjunctive treatment with vitamins B6, B12 and folate increases the efficacy of standard antidepressant treatment. Methods/Design The B-VITAGE trial is a 12-month randomized, double-blind, placebo-controlled trial of daily citalopram (20 to 40 mg plus B12(0.4 mg, B6 (25 mg and folic acid (2 mg or citalopram (20 to 40 mg plus placebo for the treatment of depression in later life. The trial aims to recruit over 300 older adults with major depression (DSM-IV and has been powered to detect the impact of an intervention associated with moderate effect size. Depressive symptoms will be rated with the Montgomery-Åsberg Depression Rating Scale (MADRS. The trial has two main outcomes of interest: a reduction of 50% or more in the MADRS total score between baseline and week 12 and the remission of the depressive episode at weeks 12, 26 and 52 according to DSM-IV criteria. We hypothesize that subjects randomly allocated to the vitamin arm of the study will be more likely to show a clinically significant improvement and achieve and maintain remission of symptoms at 12, 26 and 52 weeks. Secondary outcomes of interest include compliance with treatment, reduction in the severity of depressive symptoms, switching to different antidepressants, the use of non-pharmacological antidepressant treatments, response to treatment according to MTHFRC677T genotype, and changes in cognitive function over 52 weeks. Conclusions The results of this trial will clarify whether the systematic use of B

  7. Nonparametric Inference for Periodic Sequences

    KAUST Repository

    Sun, Ying

    2012-02-01

    This article proposes a nonparametric method for estimating the period and values of a periodic sequence when the data are evenly spaced in time. The period is estimated by a "leave-out-one-cycle" version of cross-validation (CV) and complements the periodogram, a widely used tool for period estimation. The CV method is computationally simple and implicitly penalizes multiples of the smallest period, leading to a "virtually" consistent estimator of integer periods. This estimator is investigated both theoretically and by simulation.We also propose a nonparametric test of the null hypothesis that the data have constantmean against the alternative that the sequence of means is periodic. Finally, our methodology is demonstrated on three well-known time series: the sunspots and lynx trapping data, and the El Niño series of sea surface temperatures. © 2012 American Statistical Association and the American Society for Quality.

  8. Positive periodic solutions of delayed periodic Lotka-Volterra systems

    Energy Technology Data Exchange (ETDEWEB)

    Lin Wei [Laboratory of Nonlinear Mathematics Science, Institute of Mathematics, Fudan University, Shanghai 200433 (China)]. E-mail: weilin@fudan.edu.cn; Chen Tianping [Laboratory of Nonlinear Mathematics Science, Institute of Mathematics, Fudan University, Shanghai 200433 (China)]. E-mail: tchen@fudan.edu.cn

    2005-01-17

    In this Letter, for a general class of delayed periodic Lotka-Volterra systems, we prove some new results on the existence of positive periodic solutions by Schauder's fixed point theorem. The global asymptotical stability of positive periodic solutions is discussed further, and conditions for exponential convergence are given. The conditions we obtained are weaker than the previously known ones and can be easily reduced to several special cases.

  9. Positive periodic solutions of delayed periodic Lotka-Volterra systems

    Science.gov (United States)

    Lin, Wei; Chen, Tianping

    2005-01-01

    In this Letter, for a general class of delayed periodic Lotka-Volterra systems, we prove some new results on the existence of positive periodic solutions by Schauder's fixed point theorem. The global asymptotical stability of positive periodic solutions is discussed further, and conditions for exponential convergence are given. The conditions we obtained are weaker than the previously known ones and can be easily reduced to several special cases.

  10. Fractional-period excitations in continuum periodic systems

    International Nuclear Information System (INIS)

    We investigate the generation of fractional-period states in continuum periodic systems. As an example, we consider a Bose-Einstein condensate confined in an optical-lattice potential. We show that when the potential is turned on nonadiabatically, the system explores a number of transient states whose periodicity is a fraction of that of the lattice. We illustrate the origin of fractional-period states analytically by treating them as resonant states of a parametrically forced Duffing oscillator and discuss their transient nature and potential observability

  11. Clinical effect of trichosanthes arctium lappa decoction combined with external application of mirabilite in the treatment of acute mastitis stagnation period%瓜蒌牛蒡汤加减联合芒硝外敷治疗急性乳腺炎郁滞期的临床观察

    Institute of Scientific and Technical Information of China (English)

    李幸运

    2014-01-01

    目的:探讨瓜蒌牛蒡汤加减联合芒硝外敷治疗急性乳腺炎郁滞期的临床效果,进一步指导临床。方法选取2012年1月~2014年1月在本院门诊治疗的急性乳腺炎郁滞期患者60例,按照随机对照的原则,将患者分为观察组和对照组,每组各30例,观察组30例患者给予瓜蒌牛蒡汤加减联合芒硝外敷治疗,对照组30例患者给予单纯的硫酸镁湿热敷治疗,观察对比两组的临床治疗效果以及治疗时间。结果观察组治疗总有效率明显优于对照组,差异具有统计学意义(P<0.05),观察组的治疗时间明显少于对照组,差异具有统计学意义(P<0.05)。结论瓜蒌牛蒡汤加减联合芒硝外敷治疗急性乳腺炎郁滞期临床疗效显著,降低了脓肿的形成,有效的减轻患者的痛苦,保证母乳喂养率。%Objective To discuss the clinical effect of trichosanthes arctium lappa decoction combined with external application of mirabilite in the treatment of acute mastitis stagnation period for further clinical guide. Methods Choosing 60 patients with acute mastitis stagnation period from January 2012 to January 2014 in our hospital, outpatient treatment of patients, according to the principle of randomized controlled, the patients were divided into observation group and control group, 30 cases in each group, the observation group of 30 cases were treated with trichosanthes arctium lappa decoction combined with external application of mirabilite treatment, 30 cases in the control group were treated with magnesium sulfate wet compress simple treatment, the clinical therapeutic effect of two groups were compared and the treatment time. Results In observation group, the total efficiency of treatment was better than the control group, the difference was significant, with statistical significance(P<0.05), the treatment time of observation group was less than that of control group, the difference was significant, with

  12. Dynamics of Coulombic and gravitational periodic systems

    Science.gov (United States)

    Kumar, Pankaj; Miller, Bruce N.

    2016-04-01

    We study the dynamics and the phase-space structures of Coulombic and self-gravitating versions of the classical one-dimensional three-body system with periodic boundary conditions. We demonstrate that such a three-body system may be reduced isomorphically to a spatially periodic system of a single particle experiencing a two-dimensional potential on a rhombic plane. For the case of both Coulombic and gravitational versions, exact expressions of the Hamiltonian have been derived in rhombic coordinates. We simulate the phase-space evolution through an event-driven algorithm that utilizes analytic solutions to the equations of motion. The simulation results show that the motion exhibits chaotic, quasiperiodic, and periodic behaviors in segmented regions of the phase space. While there is no evidence of global chaos in either the Coulombic or the gravitational system, the former exhibits a transition from a completely nonchaotic phase space at low energies to a mixed behavior. Gradual yet striking transitions from mild to intense chaos are indicated with changing energy, a behavior that differentiates the spatially periodic systems studied in this Rapid Communication from the well-understood free-boundary versions of the three-body problem. Our treatment of the three-body systems opens avenues for analysis of the dynamical properties exhibited by spatially periodic versions of various classes of systems studied in plasma and gravitational physics as well as in cosmology.

  13. Repelling periodic points of given periods of rational functions

    Institute of Scientific and Technical Information of China (English)

    CHANG; Jianming; FANG; Mingliang

    2006-01-01

    Let R(z) be a rational function of degree d ≥ 2. Then R(z) has at least one repelling periodic point of given period k ≥ 2, unless k = 4 and d=2, or k= 3 and d ≤ 3, or k=2 and d≤8. Examples show that all exceptional cases occur.

  14. From Periodic Properties to a Periodic Table Arrangement

    Science.gov (United States)

    Besalú, Emili

    2013-01-01

    A periodic table is constructed from the consideration of periodic properties and the application of the principal components analysis technique. This procedure is useful for objects classification and data reduction and has been used in the field of chemistry for many applications, such as lanthanides, molecules, or conformers classification.…

  15. Ap stars with variable periods

    OpenAIRE

    Mikulášek, Zdeněk; Krtička, Jiří; Janík, Jan; Zejda, Miloslav; Henry, Gegory W.; Paunzen, Ernst; Žižňovský, Jozef; Zverko, Juraj

    2013-01-01

    The majority of magnetic chemically peculiar (mCP) stars exhibit periodic light, magnetic, radio, and spectroscopic variations that can be adequately modelled as a rigidly-rotating main-sequence star with persistent surface structures. Nevertheless, there is a small sample of diverse mCP stars whose rotation periods vary on timescales of decades while the shapes of their phase curves remain unchanged. Alternating period increases and decreases have been suspected in the hot CP stars CU Vir an...

  16. 脊柱术后新斯的明对治疗老年患者卧床期腹胀的疗效观察%Neostigmine for treatment of spinal postoperative elderly patients lie in bed period curative effect observation of abdominal distension

    Institute of Scientific and Technical Information of China (English)

    李青梅; 郑光峰

    2015-01-01

    ObjectiveTo observe the neostigmine treatment of spinal postoperative elderly patients lie in bed period abdominal distension abdominal distension and other three kinds of commonly used clinical treatment method curative effect comparison.Method To our department from January 2012 to December 2012 treated 160 cases of elderly patients, postoperative for neostigmine, application, increased gastrointestinal medicine Pan Li methadone, 2% more soapy water enema, open plug plug anal and anal exhaust four ways to treat spinal abdominal distension postoperative elderly patients lie in bed.Result After treatment for 2 h. Neostigmine treatment group soon exhaust and defecate, and can normal sense no abdominal distention after eating, the effect is better than the other three groups (P<0.05). Neostigmine.ConclusionTreatment of spinal postoperative elderly patients lie in bed period abdominal distension, quick effect, operation is simple, safe, and reduce the patients pain caused by recurrent abdominal distension.%目的:观察新斯的明治疗脊柱术后老年患者卧床期出现腹胀及其它三种临床常用治疗腹胀方法的疗效比较。方法:将我科从2013年4月至2014年4月收治的160例老年患者,术后分别进行新斯的明、应用增加胃肠动力药多潘立酮、2%肥皂水灌肠、开塞露塞肛加肛管排气四种方法治疗脊柱术后老年患者卧床期腹胀。结果:经治疗2h后观察疗效。新斯的明治疗组很快排气、排便,且能正常进食后无腹胀感,效果明显优于其他三组(P<0.05)。结论:新斯的明治疗脊柱术后老年患者卧床期出现的腹胀,见效快,操作简单、安全,减轻了患者因反复腹胀引起的痛苦。

  17. The Clinical Observation of Naoxinkang Capsule in the Treatment of Qi Deficiency,Blood and Phlegm Stagnation Syndrome of Ischemic Stroke Recovery Period of 56 Cases%脑欣康胶囊治疗气虚血瘀痰阻型缺血性中风恢复期56例疗效观察

    Institute of Scientific and Technical Information of China (English)

    孙玉勇

    2014-01-01

    Objective:To observe the clinical effect of Naoxinkang Capsule in the treatment of qi deficiency,blood and phlegm stagnation syndrome of ischemic stroke recovery period.Method:107 stroke patients with condition tends to be stable in our hospital from January 2011 to December 2012 were selected,using randomized,double-blind,double-dummy,parallel control study method,they were divided into the experimental group for 56 cases and the control group for 51 cases.The experimental group was given Naoxinkang Capsule for treatment,the control group was given Xuesaitong Tablets for treatment.The clinical efficacy and the changes of hemodynamics before and after treatment between the two groups were observed and compared.Result:After treatment,the total effective rate of experimental group was 87.50%(49/56),it was significantly higher than 70.59%(36/51) of control group,the difference was statistically significant(χ2=4.674,P=0.031).The hemodynamic indexes of the two groups after treatment were significantly lower than before treatment,and the hemodynamic indexes of experimental group after treatment were significantly lower than control group,the differences were statistically significant(P<0.05). Conclusion:Naoxinkang Capsule in the treatment of qi deficiency,blood and phlegm stagnation syndrome of ischemic stroke recovery period has the remarkable curative effect,safety and effectiveness,easy to use,is worthy of clinical promotion.%目的:观察脑欣康胶囊治疗气虚血瘀痰阻型缺血性中风恢复期的临床疗效。方法:选取2011年1月-2012年12月笔者所在医院收治的107例病情趋于稳定的中风患者作为研究对象,采用随机双盲、双模拟、平行对照研究方法将其分为试验组56例和对照组51例。试验组给予脑欣康胶囊治疗,对照组给予血塞通片治疗,观察比较两组患者的中医症候疗效及治疗前后血液动力学变化情况。结果:经治疗后,试验组的治疗总有效率87

  18. Randomised controlled trial of counseling sessions, antidepressant medication, and combined treatment for major depression in primary care setting

    International Nuclear Information System (INIS)

    The study was made to determine whether counseling sessions using Egan's model combined with antidepressant medication is more effective than either treatment alone in the management of major depression in primary care. Patient aged 18 years and above with major depression on the research diagnostic criteria - a score of 13 or more on the 17 items. Hamilton rating scale for depression and a minimum duration of 4 weeks. Counseling sessions based on Egan's Model by research family physician or antidepressant medication or combination of both was performed. Hamilton rating scale for depression, Beck depression inventory, clinical interview schedule, and modified social adjustment schedule were used and assessed at 6 , 12 and 52 weeks. Patients in all groups showed a clear improvement after 12 weeks. The combination of counseling sessions and antidepressant medication is more effective than either treatment alone. Counseling sessions used by a trained family physician is an effective treatment for depressive disorders in primary care. The combination of this treatment with antidepressant medication is more effective than either treatment alone. (author)

  19. Latino Periodicals: A Selection Guide.

    Science.gov (United States)

    Guerena, Salvador, Ed.; Pisano, Vivian M., Ed.

    This guide is a collection development tool of national scope for librarians who need in-depth coverage of Latino periodicals suitable for public, school, and academic libraries. Periodicals evaluated include general interest and popular magazines and newspapers that appeal to Spanish-speaking, bilingual, and English-speaking library patrons and…

  20. Clinical Observation of Low-dosage and Long-period Xeloda in Treatment of Advanced Triple Negative Breast Cancer%低剂量长周期希罗达治疗复发晚期三阴性乳腺癌的临床研究

    Institute of Scientific and Technical Information of China (English)

    容景瑜; 张少贤; 黄景彬; 林清; 陈雁秋

    2015-01-01

    目的:观察低剂量长周期希罗达治疗复发晚期三阴性乳腺癌的有效性和安全性。方法将60例经含希罗达联合化疗8个周期后疾病达缓解或稳定的复发晚期三阴性乳腺癌患者随机分为两组,治疗组继续接受低剂量长周期希罗达维持治疗,期间进展或不能耐受毒副反应者停止化疗,对照组予以观察随诊。结果低剂量长周期希罗达维持治疗复发晚期三阴性乳腺癌有效率为73.3%,中位无进展生存期为413.7天,半数患者生存期为466.3天,化疗有效维持时间为209.3天;1年生存率70.0%,2年生存率46.6%;患者生存质量提高,肿瘤指标下降,与对照组比较,有显著性差异。主要毒副反应为手足综合征(36.67%),多为Ⅰ-Ⅱ度,其次为消化道反应(26.67%)及白细胞下降(23.3%),患者可耐受。结论低剂量长周期希罗达治疗复发晚期三阴性乳腺癌,患者的耐受性好,不良反应程度低,治疗有效,为治疗复发性三阴性乳腺癌的有效、低毒的可选方案。%Objective To observe the therapeutic effects, toxicity and side effects of low-dosage and long-period xeloda in the treatment of advanced triple negative breast cancer. Methods Sixty patients with advanced triple negative breast cancer were divided into two groups after treatment of 8 cycles’combination regimen including xeloda. 30 patients in control group then got no xeloda but follow-up clinic, and another 30 in treatment group were still treated by low-dosage and long-period xeloda. Results In the treatment group, the short-term therapeutic effect rate was 73.3%, the median progression-free sur-vival (PFS) was 413.7 days. The median survival time was 466.3 days, the effective chemotherapy-maintained time was 209.3 days, with 1-year survival of 70.0%, 2-year survival of 46.6%. The life quality of patients was improved and the level of tumor marker was decreased with

  1. Transition Period and Immunosuppression: Critical Period of Dairy Cattle Reproduction

    OpenAIRE

    K. Simenew; M. Wondu

    2013-01-01

    This seminar study is prepared on the objectives of: revising important aspects of transition period of dairy cattle and highlighting some potential areas of research and challenges for the future. It has sufficiently been discussed that improved understanding of this frontier of the biology, immunology, nutrition and management of cows during the transition period will provide the largest gains in productivity and profitability of dairy farms. In the manuscript under each specific topic, tra...

  2. Optical Periodicity Analysis of 3C 446 using Period04

    Indian Academy of Sciences (India)

    Fei Guo; Hao Jing Zhang

    2014-09-01

    All the data of the blazar 3C446 at 8, 4.8, 14 and 22 GHz, presented in publications from 1977 to 2006, have been compiled to generate light curves. The light curves show violent activity of 3C446. Using Period04 analysis method, we have found that there is a period of 7.2 yr, which is consistent with the results that we found using wavelet analysis method. We get the instability region as = 123.83.

  3. Obesity and exercise in adoloscent period

    Directory of Open Access Journals (Sweden)

    Eda Mendeş

    2011-10-01

    Full Text Available Adolescence period is a special period during which fastest growth and development occur in humans and which includes transition from childhood to adulthood. World Health Organization (WHO define 10-19 age-group individuals as adolescence and 15- 24 age-group individuals as youthood. That today’s community lacks knowledge of workout, inadequate awareness of the benefits of workout to human health and acceptance of the continuity of sedentary life gives rise to the incidence of lots of chronic diseases such as high-blood pressure, cardio-pulmonary diseases, obesity and diabetes.In recent years, childhood and adolescence obesity has become an important health problem as a result of the decline in physical activities. In this context, workout along with balanced diet is one of the precautions that can be suggested in terms of the prevention of obesity. The purpose of this study (compilation is to provide information on keeping human health by means of an awareness of workout in adolescence period which is the most important stage preceding adulthood; to summarize the issue in relation to the written documents existing in the relevant literature, and to make suggestions about healthy future generations through workout in adolescence period.In conclusion, successful results regarding the treatment of obesity in adolescence can be achieved through aerobics along with low-calorie diet.

  4. The Periodic Table in Croatia

    Directory of Open Access Journals (Sweden)

    Raos, N.

    2011-12-01

    Full Text Available The Croatian (Yugoslav Academy of Sciences and Arts was the first academy to elect D. I. Mendeleev as its honorary member (1882, whereas the periodic table of the elements has been taught regularly at the Zagreb University since 1888. The early interest of Croatian chemists in the periodic table should be attributed primarily to their pan-Slavic attitude, particularly as proof that Slavic people were able to produce "their own Newtons" (M. V. Lomonosov and D. I. Mendeleev. Such enthusiastic views, however, did not help in analyzing the contribution of Mendeleev and other scientists to the discovery and development of the periodic table of the elements.

  5. Entanglement Entropy of Periodic Sublattices

    CERN Document Server

    He, Temple; Vandoren, Stefan

    2016-01-01

    We study the entanglement entropy (EE) of Gaussian systems on a lattice with periodic boundary conditions, both in the vacuum and at nonzero temperatures. By restricting the reduced subsystem to periodic sublattices, we can compute the entanglement spectrum and EE exactly. We illustrate this for a free (1+1)-dimensional massive scalar field at a fixed temperature. Consistent with previous literature, we demonstrate that for a sufficiently large periodic sublattice the EE grows extensively, even in the vacuum. Furthermore, the analytic expression for the EE allows us probe its behavior both in the massless limit and in the continuum limit at any temperature.

  6. Clinical research of hypnotic therapy in treatment of patients with mental disorders due to alcohol in convalescent period%催眠疗法在酒精所致精神障碍患者康复期治疗中的临床研究

    Institute of Scientific and Technical Information of China (English)

    王伟; 张撰荣; 冯合星; 王晨光; 白萍; 殷文英; 王艳

    2014-01-01

    目的:观察催眠疗法对酒精所致精神障碍患者康复期的作用,探讨治疗酒精所致精神障碍的新疗法。方法:通过前瞻性对照研究,将酒精所致精神障碍患者随机分为研究组和对照组,研究组患者在常规戒酒治疗的基础上,利用催眠疗法进行干预,对照组患者单用常规戒酒治疗。治疗1个月前后分别采用明尼苏达个性量表( MMPI)、汉密尔顿焦虑量表( HAMA)和汉密尔顿抑郁量表(HAMD)作为测查工具,进行回顾性分析。结果:研究组酒精所致精神障碍患者除 Sc、Si 量表外,其他 MMPI 量表的 t 分均比治疗前显著降低(P 均<0.05)。研究组治疗前后 Hs、D、Hy、Pd、Mf、Pa、Pt、Ma 量表的 t 分减分值与对照组比较,差异有统计学意义(P 均<0.05)。治疗前后两组患者 HAMA、HAMD减分均显著降低(P 均<0.05),研究组患者减分率与对照组比较差异有统计学意义(P 均<0.05)。结论:综合运用催眠疗法对酒精所致精神障碍患者的治疗效果显著,无不良反应,值得临床推广。%Objective:To explore effects of hypnotic therapy in treatment of patients with mental disorders due to alcohol in convalescent period and explore new therapies for the treatment of mental disorders due to alcohol. Methods:Through a prospective control study, the patients with mental disorders due to alcohol were selected and randomly divided into research group and control group, wherein the cases in research group were given the hypnosis intervention on the basis of the conventional alcohol withdrawal treatment, whereas those in control group were only given the conventional alcohol withdrawal treatment. Before and 1 month after the treatment, Minnesota personality inventory (MMPI), Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) were used for the retrospective analysis. Results: For research group, except Sc and Si scales, the other T points in MMPI scale

  7. Periodicities in photospheric magnetic flux

    Institute of Scientific and Technical Information of China (English)

    SONG; Wenbin; WANG; Jingxiu

    2006-01-01

    Magnetic field plays an important role in solar structure and activity. In principle, the determination of magnetic flux would provide the best general-purpose index of solar activity. Currently, the periodicity studies corresponding to photospheric magnetic flux (PMF) are very few possibly due to the absence of a uniform flux sequence. In this paper, by using 383 NSO/Kitt Peak magnetic synoptic charts we reconstruct a flux sequence from February 1975 to August 2003 and perform a relatively systemic periodicity analysis with two methods of the Scargle periodogram and the Morlet wavelet transform. As a result, four periods are found at around 1050, 500, 300 and 160 days. We analyze these periods' temporal variabilities in detail and discuss their respective origins briefly.

  8. Periodicities in Aerosol Optical Depths

    CERN Document Server

    Ramachandran, S; Verma, Amit; Panigrahi, Prasanta K

    2011-01-01

    We investigate the temporal and spatial variability in aerosol optical depth (AOD) over different geographic locations in India due to their important role in the earth-atmosphere radiation budget. The use of continuous wavelet transform pinpoints the spatio-temporal non-stationarity of the periodic variations in the AOD depending on local factors. The optimal time-frequency localization ability of Morlet wavelet accurately isolates the periodic features in the different frequency domains, to study the variations in the dominant periods due to local effects. The origin of the effects on the periodic modulations is then related to physical phenomena of regional nature, which throws considerable light on the observed variations in aerosol optical depths. We also find the phase relationship between different locations and to identify the possible correlations between different geographic locations and related environmental variations.

  9. 75 FR 65593 - Periodic Reporting

    Science.gov (United States)

    2010-10-26

    ... Rules Concerning Periodic Reporting of Service Performance Measurements and Customer Satisfaction, May... From the Federal Register Online via the Government Publishing Office POSTAL REGULATORY COMMISSION... waiver request. SUMMARY: The Commission is establishing a docket to address a recent Postal...

  10. Measuring Scars of Periodic Orbits

    CERN Document Server

    Kaplan, L

    1999-01-01

    The phenomenon of periodic orbit scarring of eigenstates of classically chaotic systems is attracting increasing attention. Scarring is one of the most important ``corrections'' to the ideal random eigenstates suggested by random matrix theory. This paper discusses measures of scars and in so doing also tries to clarify the concepts and effects of eigenfunction scarring. We propose a new, universal scar measure which takes into account an entire periodic orbit and the linearized dynamics in its vicinity. This measure is tuned to pick out those structures which are induced in quantum eigenstates by unstable periodic orbits and their manifolds. It gives enhanced scarring strength as measured by eigenstate overlaps and inverse participation ratios, especially for longer orbits. We also discuss off-resonance scars which appear naturally on either side of an unstable periodic orbit.

  11. Prime numbers: periodicity, chaos, noise

    OpenAIRE

    Bershadskii, A.

    2011-01-01

    Logarithmic gaps have been used in order to find a periodic component of the sequence of prime numbers, hidden by a random noise (stochastic or chaotic). The recovered period for the sequence of the first 10000 prime numbers is equal to 8\\pm1 (subject to the prime number theorem). For small and moderate values of the prime numbers (first 2000 prime numbers) this result has been directly checked using the twin prime killing method.

  12. Cohort postponement and period measures

    OpenAIRE

    Joshua R. Goldstein; Thomas Cassidy

    2010-01-01

    We introduce a new class of models in which demographic behavior such as fertility is postponed by differing amounts depending only on cohort membership. We show how this model fits into a general framework of period and cohort postponement that includes the existing models in the literature, notably those of Bongaarts and Feeney and Kohler and Philipov. The cohort-based model shows the effects of cohort shifts on period fertility measures and provides an accompanying tempo-adjusted measure o...

  13. Periodic billiard trajectories in polyhedra

    CERN Document Server

    Bedaride, Nicolas

    2011-01-01

    We consider the billiard map inside a polyhedron. We give a condition for the stability of the periodic trajectories. We apply this result to the case of the tetrahedron. We deduce the existence of an open set of tetrahedra which have a periodic orbit of length four (generalization of Fagnano's orbit for triangles), moreover we can study completly the orbit of points along this coding.

  14. Period Integrals and Tautological Systems

    CERN Document Server

    Lian, Bong H; Yau, Shing-Tung

    2011-01-01

    We study period integrals of CY hypersurfaces in a partial flag variety. We construct a holonomic system of differential equations which govern the period integrals. By means of representation theory, a set of generators of the system can be described explicitly. The results are also generalized to CY complete intersections. The construction of these new systems of differential equations have lead us to the notion of a tautological system.

  15. Dyes Waste Treatments

    Directory of Open Access Journals (Sweden)

    Siew-Teng Ong

    2011-02-01

    Full Text Available Dyes waste represent one of the problematic groups of pollutants because their presence can be easily identified by the human eye and they are not easily biodegradable. This literature review paper highlights and provides an overview of dyes waste treatments for 3 years period, from 2008–2010. The noteworthy treatment processes for dyes waste include biological treatment, catalytic oxidation, filtration, sorption process and combination treatments.

  16. Substance Use in the Perinatal Period.

    Science.gov (United States)

    Forray, Ariadna; Foster, Dawn

    2015-11-01

    Perinatal substance use remains a major public health problem and is associated with a number of deleterious maternal and fetal effects. Polysubstance use in pregnancy is common and can potentiate adverse maternal and fetal outcomes. Tobacco is the most commonly used substance in pregnancy, followed by alcohol and illicit substances. The treatments for perinatal substance use are limited and consist mostly of behavioral and psychosocial interventions. Of these, contingency management has shown the most efficacy. More recently, novel interventions such as progesterone for postpartum cocaine use have shown promise. The purpose of this review is to examine the recent literature on the use of tobacco, alcohol, cannabis, stimulants, and opioids in the perinatal period, their effects on maternal and fetal health, and current treatments. PMID:26386836

  17. Baseline study of methane emission from anaerobic ponds of palm oil mill effluent treatment.

    Science.gov (United States)

    Yacob, Shahrakbah; Ali Hassan, Mohd; Shirai, Yoshihito; Wakisaka, Minato; Subash, Sunderaj

    2006-07-31

    The world currently obtains its energy from the fossil fuels such as oil, natural gas and coal. However, the international crisis in the Middle East, rapid depletion of fossil fuel reserves as well as climate change have driven the world towards renewable energy sources which are abundant, untapped and environmentally friendly. Malaysia has abundant biomass resources generated from the agricultural industry particularly the large commodity, palm oil. This paper will focus on palm oil mill effluent (POME) as the source of renewable energy from the generation of methane and establish the current methane emission from the anaerobic treatment facility. The emission was measured from two anaerobic ponds in Felda Serting Palm Oil Mill for 52 weeks. The results showed that the methane content was between 35.0% and 70.0% and biogas flow rate ranged between 0.5 and 2.4 L/min/m(2). Total methane emission per anaerobic pond was 1043.1 kg/day. The total methane emission calculated from the two equations derived from relationships between methane emission and total carbon removal and POME discharged were comparable with field measurement. This study also revealed that anaerobic pond system is more efficient than open digesting tank system for POME treatment. Two main factors affecting the methane emission were mill activities and oil palm seasonal cropping. PMID:16125215

  18. Baseline study of methane emission from anaerobic ponds of palm oil mill effluent treatment.

    Science.gov (United States)

    Yacob, Shahrakbah; Ali Hassan, Mohd; Shirai, Yoshihito; Wakisaka, Minato; Subash, Sunderaj

    2006-07-31

    The world currently obtains its energy from the fossil fuels such as oil, natural gas and coal. However, the international crisis in the Middle East, rapid depletion of fossil fuel reserves as well as climate change have driven the world towards renewable energy sources which are abundant, untapped and environmentally friendly. Malaysia has abundant biomass resources generated from the agricultural industry particularly the large commodity, palm oil. This paper will focus on palm oil mill effluent (POME) as the source of renewable energy from the generation of methane and establish the current methane emission from the anaerobic treatment facility. The emission was measured from two anaerobic ponds in Felda Serting Palm Oil Mill for 52 weeks. The results showed that the methane content was between 35.0% and 70.0% and biogas flow rate ranged between 0.5 and 2.4 L/min/m(2). Total methane emission per anaerobic pond was 1043.1 kg/day. The total methane emission calculated from the two equations derived from relationships between methane emission and total carbon removal and POME discharged were comparable with field measurement. This study also revealed that anaerobic pond system is more efficient than open digesting tank system for POME treatment. Two main factors affecting the methane emission were mill activities and oil palm seasonal cropping.

  19. Effect of Simo decoction,Clostridium butyricnm powder in treatment of neonatal asphyxia during perinatal period after feeding intolerance%四磨汤与酪酸梭菌活菌散治疗新生儿围生期窒息后喂养不耐受的观察

    Institute of Scientific and Technical Information of China (English)

    卓文娟

    2012-01-01

    [目的]观察四磨汤、酪酸梭菌活菌散治疗新生儿围生期窒息后喂养不耐受的情况. [方法]选择本院有围生期窒息后喂养不耐受的新生儿68例为实验对象,并随机分为对照组(n=36)和治疗组(n=32),羊水有胎粪污染者,两组均予洗胃,洗胃后禁食6h才开奶,对照组予枯草杆菌二联活菌颗粒治疗,治疗组予四磨汤、酪酸梭菌活菌散治疗.每天记录呕吐的次数、呕吐量、进食的奶量、大便次数、腹胀消失的日龄、恢复出生体重的日龄等. [结果]实验组呕吐次数减少、呕吐及腹胀消失时间提前、达50 kCal/(kg·d)日龄,恢复出生体重的日龄均提前,差异有统计学意义(P<0.05).[结论]四磨汤、酪酸梭菌活菌散治疗新生儿围生期窒息后喂养不耐受,能促进胃肠功能成熟,提高喂养的耐受性,而且安全.%[Objective] To observe the effect of Simo decoction,the condition of intolerant infants under Clostridium butyricum powder in treatment of neonatal asphyxia during perinatal period after feeding. [Methods] 68 infants selected as cases and were randomly divided into the control group (n=36) and treatment group (n = 32) cases with amniotic fluid meconium pollution in two groups were treated with gastric lav-age,after gastric lavage they could not open the milk until fasting for 6 hours. The control group received the treatment of Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines,Live,and the treatment group was treated with the Simo decoction,Clostridium bulyricutn powder treatment,daily record of vomiting,amount of milk,stool frequency,abdominal distention disappeared days of age,the days of birth weight,such as age of recovery. [Results] The experimental group reduced frequency of vomiting ,and vomiting, abdominal distension disappeared ahead of time,up to 50 kCal/Ckg·) days in advance, to restore the birth weight of the days in advance,with statistically significant (P<0. 05

  20. Ap stars with variable periods

    CERN Document Server

    Mikulášek, Zdeněk; Janík, Jan; Zejda, Miloslav; Henry, Gegory W; Paunzen, Ernst; Žižňovský, Jozef; Zverko, Juraj

    2013-01-01

    The majority of magnetic chemically peculiar (mCP) stars exhibit periodic light, magnetic, radio, and spectroscopic variations that can be adequately modelled as a rigidly-rotating main-sequence star with persistent surface structures. Nevertheless, there is a small sample of diverse mCP stars whose rotation periods vary on timescales of decades while the shapes of their phase curves remain unchanged. Alternating period increases and decreases have been suspected in the hot CP stars CU Vir and V901 Ori, while rotation in the moderately cool star BS Cir has been decelerating. These examples bring new insight into this theoretically unpredicted phenomenon. We discuss possible causes of such behaviour and propose that dynamic interactions between a thin, outer, magnetically-confined envelope braked by the stellar wind, and an inner faster-rotating stellar body are able to explain the observed rotational variability

  1. Periodicity, the Canon and Sport

    Directory of Open Access Journals (Sweden)

    Thomas F. Scanlon

    2015-10-01

    Full Text Available The topic according to this title is admittedly a broad one, embracing two very general concepts of time and of the cultural valuation of artistic products. Both phenomena are, in the present view, largely constructed by their contemporary cultures, and given authority to a great extent from the prestige of the past. The antiquity of tradition brings with it a certain cachet. Even though there may be peripheral debates in any given society which question the specifics of periodization or canonicity, individuals generally accept the consensus designation of a sequence of historical periods and they accept a list of highly valued artistic works as canonical or authoritative. We will first examine some of the processes of periodization and of canon-formation, after which we will discuss some specific examples of how these processes have worked in the sport of two ancient cultures, namely Greece and Mesoamerica.

  2. On composites with periodic structure

    Science.gov (United States)

    Nemat-Nasser, S.; Iwakuma, T.; Hejazi, M.

    1982-01-01

    The overall moduli of a composite with an isotropic elastic matrix containing periodically distributed (anisotropic) inclusions or voids, can be expressed in terms of several infinite series which only depend on the geometry of the inclusions or voids, and hence can be computed once and for all for given geometries. For solids with periodic structures these infinite series play exactly the same role as does Eshelby's tensor for a single inclusion or void in an unbounded elastic medium. For spherical and circular-cylindrical geometries, the required infinite series are calculated and the results are tabulated. These are then used to estimate the overall elastic moduli when either the overall strains or the overall stresses are prescribed, obtaining the same results. These results are compared with other estimates and with experimental data. It is found that the model of composites with periodic structure yields estimates in excellent agreement with the experimental observations.

  3. Profit optimization during crisis periods

    Directory of Open Access Journals (Sweden)

    Sorin BRICIU

    2013-06-01

    Full Text Available This article highlights the authors’ attempt to identify a simple and effective calculation method for profit optimization in crisis periods. This method was identified based on the analysis of a representative sample of professionals working in both state-owned and private bakery companies in Romania. The article also presents methodological case studies for three bakery products aimed to highlight the changes in results according to changes of variables in the current business environment. The results obtained are presented and analysed by the authors. The article ends with the authors’ conclusions on the benefits of the Direct-Costing Method and profit optimisation in crisis periods.

  4. The study protocol of the Norwegian randomized controlled trial of electroconvulsive therapy in treatment resistant depression in bipolar disorder

    Directory of Open Access Journals (Sweden)

    Oedegaard Ketil J

    2010-02-01

    Full Text Available Abstract Background The treatment of depressive phases of bipolar disorder is challenging. The effects of the commonly used antidepressants in bipolar depression are questionable. Electroconvulsive therapy is generally considered to be the most effective treatment even if there are no randomized controlled trials of electroconvulsive therapy in bipolar depression. The safety of electroconvulsive therapy is well documented, but there are some controversies as to the cognitive side effects. The aim of this study is to compare the effects and side effects of electroconvulsive therapy to pharmacological treatment in treatment resistant bipolar depression. Cognitive changes and quality of life during the treatment will be assessed. Methods/Design A prospective, randomised controlled, multi-centre six- week acute treatment trial with seven clinical assessments. Follow up visit at 26 weeks or until remission (max 52 weeks. A neuropsychological test battery designed to be sensitive to changes in cognitive function will be used. Setting: Nine study centres across Norway, all acute psychiatric departments. Sample: n = 132 patients, aged 18 and over, who fulfil criteria for treatment resistant depression in bipolar disorder, Montgomery Åsberg Depression Rating Scale Score of at least 25 at baseline. Intervention: Intervention group: 3 sessions per week for up to 6 weeks, total up to 18 sessions. Control group: algorithm-based pharmacological treatment as usual. Discussion This study is the first randomized controlled trial that aims to investigate whether electroconvulsive therapy is better than pharmacological treatment as usual in treatment resistant bipolar depression. Possible long lasting cognitive side effects will be evaluated. The study is investigator initiated, without support from industry. Trial registration NCT00664976

  5. Glass Waveguides for Periodic Poling

    DEFF Research Database (Denmark)

    Fage-Pedersen, Jacob; Jacobsen, Rune Shim; Kristensen, Martin

    2005-01-01

    Planar silica-based waveguide devices have been developed for second-harmonic generation by poling with periodic electrodes. We show that detrimental charge transport can occur along interfaces, but with proper choice of fabrication, high-quality devices are obtained....

  6. Periodic progress report, 6 months

    DEFF Research Database (Denmark)

    Juhl, Thomas Winther; Nielsen, Jakob Skov

    This is the first progress report of the BriteEuram project named "High Power Laser Cutting for Heavy Industry" ("Powercut"). The report contains a summary of the objectives of the first period, an overview of the technical progress, a comparison between the planed and the accomplished work...

  7. Pairs of dual periodic frames

    DEFF Research Database (Denmark)

    Christensen, Ole; Goh, Say Song

    2012-01-01

    is needed. The purpose of the present paper is to provide constructions of dual pairs of frames in the setting of the Hilbert space of periodic functions L2(0,2π). The frames constructed are given explicitly as trigonometric polynomials, which allows for an efficient calculation of the coefficients...

  8. Rotational Period of 2770 Tsvet

    Science.gov (United States)

    Franco, Lorenzo; Papini, Riccardo

    2014-07-01

    Photometric observations of main-belt asteroid 2770 Tsvet were made over three nights during 2014 March. Lightcurve analysis shows a synodic period P = 7.82 ± 0.01 h with an amplitude A = 0.47 ± 0.03 mag.

  9. Shanghai's Fashion During Republic Period

    Institute of Scientific and Technical Information of China (English)

    卞向阳

    2004-01-01

    The goal of this research is to describe and analyze Shanghai's fashion during Republic Period. Shanghai's fashion during Republic Period plays a special role in fashion history of China and Shanghai history. In the paper, three aspects including the fashion centre of China as well as Far East, men's fashion and women's fashion in Shanghai are discussed. The style, textiles, color, decoration and combination of clothing are described. Many costumes from the Clothing Museum at Donghua University and private collections as well as some historical writings, photographs and publications are elucidated and corroborated to give a more detailed description about Shanghai's fashion during that period.Here are some tentative conclusions. Firstly, Shanghai had always been the fashion center in China even Far East during Republic Period. Modeng was the main reflection of Shanghai fashion. Secondly, the traditional clothing exerted less influence and was less widely used, some kinds and combinations were out of fashion gradually. The fashion was described to be highly stylized, exquisite and concise. Thirdly, the influence of Western Style was further greater. The fashion in Shanghai was almost synchronous with fashion of Paris. Some western clothing was directly used in daily life and the elements of Western Style had an increasingly wide utilization. Fourthly, the New Chinese Style whose representatives were Qipao and Zhongshan Zhuang appeared and popularized in Shanghai. The fashion of Qipao changed frequently. Finally, the fashion in Shanghai called Shanghai Style could be summarized fashionable, exquisite, rapidly changeable, which is harmonious of both ancient and modern, Chinese and foreign.

  10. Portfolio Selection and Insurance Period

    OpenAIRE

    Aoba, Nobuko

    2001-01-01

    This paper examines market risks, portfolio selection and period of insurance in a life insurance market. Date from many countries indicate that over ninety percent of bankruptcies of life insurers are due of failures in financial risk management. Financial risk management is therefore central. ...

  11. Periodic solutions and slow manifolds

    NARCIS (Netherlands)

    Verhulst, F.

    2006-01-01

    After reviewing a number of results from geometric singular perturbation theory, we give an example of a theorem for periodic solutions in a slow manifold. This is illustrated by examples involving the van der Pol-equation and a modified logistic equation. Regarding nonhyperbolic transitions we disc

  12. PERIODIC COMPLEMENTARY BINARY SEQUENCE PAIRS

    Institute of Scientific and Technical Information of China (English)

    XuChengqian; ZhaoXiaoqun

    2002-01-01

    A new set of binary sequences-Periodic Complementary Binary Sequence Pair (PCSP)is proposed .A new class of block design-Difference Family Pair (DFP)is also proposed .The relationship between PCSP and DFP,the properties and exising conditions of PCSP and the recursive constructions for PCSP are given.

  13. PERIODIC COMPLEMENTARY BINARY SEQUENCE PAIRS

    Institute of Scientific and Technical Information of China (English)

    Xu Chengqian; Zhao Xiaoqun

    2002-01-01

    A new set of binary sequences-Periodic Complementary Binary Sequence Pair (PCSP) is proposed. A new class of block design-Difference Family Pair (DFP) is also proposed.The relationship between PCSP and DFP, the properties and existing conditions of PCSP and the recursive constructions for PCSP are given.

  14. Soliton Management in Periodic Systems

    CERN Document Server

    Malomed, Boris A

    2006-01-01

    During the past ten years, there has been intensive development in theoretical and experimental research of solitons in periodic media. This book provides a unique and informative account of the state-of-the-art in the field. The volume opens with a review of the existence of robust solitary pulses in systems built as a periodic concatenation of very different elements. Among the most famous examples of this type of systems are the dispersion management in fiber-optic telecommunication links, and (more recently) photonic crystals. A number of other systems belonging to the same broad class of spatially periodic strongly inhomogeneous media (such as the split-step and tandem models) have recently been identified in nonlinear optics, and transmission of solitary pulses in them was investigated in detail. Similar soliton dynamics occurs in temporal-domain counterparts of such systems, where they are subject to strong time-periodic modulation (for instance, the Feshbach-resonance management in Bose-Einstein conde...

  15. Model selection in periodic autoregressions

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans); R. Paap (Richard)

    1994-01-01

    textabstractThis paper focuses on the issue of period autoagressive time series models (PAR) selection in practice. One aspect of model selection is the choice for the appropriate PAR order. This can be of interest for the valuation of economic models. Further, the appropriate PAR order is important

  16. 76 FR 8325 - Periodic Reporting

    Science.gov (United States)

    2011-02-14

    ... Service Performance Measurements and Customer Satisfaction, May 25, 2010, at 22-24 (Order No. 465). Order... From the Federal Register Online via the Government Publishing Office POSTAL REGULATORY COMMISSION... certain temporary waivers from periodic reporting of service performance measurement. Establishing...

  17. A Study on the Treatment of Gynecological Disease during the Post-menstruation Period through the Method of Regulating Menstru-ation Cycle Advocated by National TCM Master XIA Guicheng%国医大师夏桂成教授调周法经后期证治探析

    Institute of Scientific and Technical Information of China (English)

    钱菁; 卢苏

    2016-01-01

    ABSTRAT:To treat the gynecological disease,national TCM master Xia Guicheng advocates the method of regulating menstru-ation cycle.He believes that kidney yin and essence are developing during the post-menstruation period which is of vital impor-tance to menstruation.The main methods of treatment of gynecological disease are nourishing yin and blood accompanied by reinforcing yang,and taking peaceful mind into value for its benefit for the production of kidney yin and tranquilizing mind.Ac-cording to the yin-yang waxing and waning circular motion cycle theory,post-menstruation period was divided into early,mid-dle,and terminal stages.On the basis of this stage-classification type,He put forward a body of methodologies for diagnosis and treatment:nourishing yin and blood and allowing patients to maintain calm minds during the early stage,nourishing yin to reinforcing yang and reinforcing yin from yang in the middle stage and regulating yin and yang at the terminal stage.%国医大师夏桂成教授倡导调周法治疗妇科疾病,认为经后期是肾阴天癸滋长的时期,对奠定月经物质基础至关重要。其治疗以滋阴养血,佐以助阳为主,并强调静能生水、宁心安神。根据阴阳消长转化圆运动周期理论,将经后期再分为初、中、末3个时期,提出了经后初期血中养阴、以静为主;经后中期滋阴助阳,静中有动;经后末期阴阳并调,动静结合的诊疗方法。

  18. Vertebrate fauna of the Roman period, migrations period and Medieval period in Vojvodina (Serbia

    Directory of Open Access Journals (Sweden)

    Radmanović Darko P.

    2014-01-01

    Full Text Available Based on current published and unpublished research results, a total of 16 vertebrate species members of mammal (Mammalia, bird (Aves and osteichthyes (Osteichthyes classes have been registered at 11 archaeological sites from the Roman Period in Vojvodina. Mammals dominate with 12 species and one genus, birds are present with 3 species, and osteichthyes with one. From the Migration Period, at 9 sites, 22 vertebrate species have been registered, of which 13 species and one genus of mammals, 4 species and one genus of birds, and 5 species from the Osteichthyes class. At 8 sites from the Medieval Period, 16 vertebrate species have been registered. Mammals are the most numerous class with 10 species and one genus, while birds are present with 4 species and one genus. Furthermore, two species of osteichthyes have also been registered.

  19. Transition Period and Immunosuppression: Critical Period of Dairy Cattle Reproduction

    Directory of Open Access Journals (Sweden)

    K. Simenew

    2013-04-01

    Full Text Available This seminar study is prepared on the objectives of: revising important aspects of transition period of dairy cattle and highlighting some potential areas of research and challenges for the future. It has sufficiently been discussed that improved understanding of this frontier of the biology, immunology, nutrition and management of cows during the transition period will provide the largest gains in productivity and profitability of dairy farms. In the manuscript under each specific topic, transition cow program and reproductive performance, immunosuppressant effect of transition period, early predictors of disorders and major abnormalities are discussed in an informative way. Future potential areas of research and possible challenges are also indicated briefly. Finally, it is concluded that despite decades of research in the area of transition cow health and management the high incidence of health disorders around calving continues to negatively affect milk production and reproductive performance; and as recommendation, implementing a transition nutrition program with the help of nutritionists can help dairy herd avoid most of the costly problems and molecular level research studies should get due attention to further understand the situation and devise proper intervention techniques.

  20. Clinical Practice Guidelines for postoperative period of thoracic surgery.

    Directory of Open Access Journals (Sweden)

    Frank Carlos Alvarez Li

    2009-03-01

    Full Text Available Clinical Practice Guidelines for postoperative period of thoracic surgery. It is the period between the suture of the surgical wound and the total rehabilitation of the patient, which usually occurs in the Intensive Care Unit. This document includes a review and update of the main aspects such as classification, postoperative treatment, stressing the actions to face any complication. It includes assessment guidelines focused on the most important aspects to be accomplished.

  1. Geopulsation, Volcanism and Astronomical Periods

    Institute of Scientific and Technical Information of China (English)

    Yang Xuexiang; Chen Dianyou; Yang Xiaoying; Yang Shuchen

    2000-01-01

    Volcanism is mainly controlled by the intermittent release of energy in the earth. As far as the differential rotation of the earth's inner core is concerned, the Galactic Year may change the gravitational constant G, the solar radiative quantity and the moving speed of the solar system and affect the exchange of angular momentum between core and mantle as well as the energy exchange between crust and mantle. As a result, this leads to eruptions of superplumes and magma, and controls the energy flow from core - mantle boundary (CMB) to crust. When the earth' s speed decreases, it will release a huge amount of energy. They are the reason of the correspondence of the volcanic cycles one by one with the astronomical periods one by one. According to the astronomical periods, volcanic eruptions may possibly be predicted in the future.

  2. Social Research On Renaissance Period

    Institute of Scientific and Technical Information of China (English)

    张蕾蕾

    2009-01-01

    The historical period known as the Renaissance spans the fifteenth and siXteenth centuries. ‘Renaissance'means‘re-birth'in French and during this time Europe left behind the mindset of the Midge Ages and created the beginnings of the modern world.This thesis mainly rotates on the background,the main features and significance of Renaissance,especially focuses on the discovery of man and the humanism and the detailed unfolding of the society on several aspect in Renaissance.

  3. 重型颅脑损伤行亚低温治疗早期肠内营养的护理研究%Study of nursing methods of enteral nutrition during earlier period subhypothermic treatment of patients with severe head injury

    Institute of Scientific and Technical Information of China (English)

    李志华; 孙建; 张建芳

    2009-01-01

    Objective To study the nursing methods of enteral nutrition during earlier period treatment of patients with severe head injury. Methods 72 patients were divided into EN and PN groups randomly. Two groups had accepted treatment of subhypethermic afte 24 hours they were injuried. In the same time, EN group pa-tients were accepted enterul nutrition and PN group patients were accepted parenterul nutrition. Results (1) There no significant deviation of nutritional state between the patients of two groups after they accepted treatment of nutritional support. (2) Enteral nutrition can prevent the occurrence of stress ulcer and cut down the merbitity of phlebitis. (3) The blood sugar level of patients of group EN was stable and there was no disadvantage of hepatic function. But there were high morbilities of disadvantage of hepatic function and high blood Sugar level in the pa-tients group PN. Conclusions There are more advantages such as security, utility, low price, low complications and so on. Enteral nutrition can substitute for parenteral nutrition.%目的 探讨重型颅脑损伤亚低温期间早期肠内营养的护理方法.方法 将72例重型颅脑损伤的患者随机分成EN、PN两组,均在伤后12 h内行亚低温治疗,同时行肠内营养及肠外营养.结果 ①两组病人营养支持前后的营养状况无明显改变(P>0.05);②与肠外营养相比,肠内营养可有效预防应激性溃疡的发生,大大降低静脉炎的发生;③肠内营养组血糖水平较稳定,且对肝功能无损害.而肠外营养组有明显的肝功能损害且易产生高葡萄糖血症.结论 重型颅脑损伤亚低温治疗期间早期行肠内营养具有安全有效、费用低、并发症少等优点,可替代肠外营养.

  4. 对内观疗法辅助治疗精神分裂症疗效的1年随访:一项单盲、随机对照研究%Single-blind, randomized controlled trial of effecitveness of Naikan therapy as an adjuncitve treatment for schizophrenia over a one-year follow-up period

    Institute of Scientific and Technical Information of China (English)

    张红; 李晨虎; 赵立宇; 占归来

    2015-01-01

    Background:Current treatments for schizophrenia are otfen only paritally effecitve. Aim:Assess the possible benefit of using adjunctive Naikan therapy, a cognitive approach based on self-relfeciton that originated in Japan for the treatment of schizophrenia. Methods:Atfer resoluiton of acute psychoitc symptoms, 235 psychiatric inpaitents with schizophrenia who had a middle school educaiton or higher were randomly assigned to a control group (n=112) that received routine medication and inpatient rehabilitative treatment or an intervention group (n=123) that also received adjunctive Naikan therapy for 2 hours daily, 5 days a week for 4 weeks. The patients were then discharged and followed up for 12 months. The Posiitve and Negaitve Syndrome Scale (PANSS), Personal and Social Performance scale (PSP), and Insight and Atttude Quesitonnaire (ITAQ) were used to assess paitents at enrollment, atfer the 1-month interveniton, and atfer the 12-month follow-up. Evaluators were blind to the group assignment of paitents. Results:Only 13(10.6%) of the interveniton group paritcipants relapsed over the 12-month follow-up, but 23 (20.5%)control group paritcipants relapsed (X2=4.50,p=0.034). Using a modiifed inteniton-to-treat analysis and a repeated measure analysis of variance, the PANSS, PSP, and ITAQ total scores all showed signiifcantly greater improvement over the 12-month follow-up in the Naikan group than in the control group. The drop in mean chlorpromazine-equivalent dosage from enrollment to the end of follow-up was signiifcantly different in the intervention group but not in the control group, though the change in dosage over time between groups was not staitsitcally signiifcant. Conclusions:This study provides robust support for the effecitveness of Naikan therapy as an adjuncitve treatment during the recovery period of schizophrenia. Compared to treatment as usually, adjuncitve Naikan therapy can sustain the improvement in psychotic symptoms achieved during acute

  5. Pegylated interferon in HBeAg-positive and -negative chronic hepatitis B patients: post-treatment 1-year results of three Turkish centres.

    Science.gov (United States)

    Yamazhan, Tansu; Kurtaran, Behice; Pullukçu, Hüsnü; Yüksel, Esma; Özkaya, Deniz; Taşbakan, Meltem Işıkgöz; Sipahi, Oğuz Reşat; Durusoy, Raika; Aksu, Hasan Salih Zeki

    2014-12-01

    In this study, we aimed to evaluate the 1-year post-treatment follow-up results of 112 patients who received pegylated interferon (PEG-IFN) for 52 weeks. HBeAg negativity/seroconversion and/or negative HBV-DNA at the end of the treatment were considered as response. Patients who had response at the end of treatment but had HBV-DNA breakthrough during 1-year follow-up were considered as relapse. The study group comprised 112 cases (34 HBeAg-positive, 78 HBeAg-negative). In HBeAg-positive and -negative cases, end-of-treatment response rates were 2·9% and 60·2%, whereas 1-year sustained virological response rates were 0 and 33·3%, respectively. When we compared relapse cases versus cases with response at the end of 1-year follow-up, being female and having low viral load were the two parameters associated with higher response rates (Chi-square, P  =  0·028; Mann-Whitney U test, P  =  0·023). Overall non-response rates to PEG-IFN were high (57·1%). Results in HBeAg-positive cases were disappointing.

  6. Role of sublingual asenapine in treatment of schizophrenia

    Directory of Open Access Journals (Sweden)

    Citrome L

    2011-05-01

    Full Text Available Leslie CitromeNew York University School of Medicine, Department of Psychiatry, New York, NY, USAAbstract: Asenapine tablets are a new option for the treatment of schizophrenia. Sublingual administration is essential because bioavailability if ingested is less than 2%. Efficacy is supported by acute and long-term randomized controlled studies conducted by the manufacturer, with asenapine 5 mg twice daily evidencing superiority over placebo in six-week studies of acute schizophrenia, and flexibly-dosed asenapine (modal dose 10 mg twice daily superior to placebo in a 26-week maintenance of response study. Tolerability advantages over some second-generation antipsychotics, such as olanzapine, include a relatively favorable weight and metabolic profile, as demonstrated in a 52-week randomized, head-to-head, double-blind clinical trial. Although dose-related extrapyramidal symptoms and akathisia can be present, the frequency of these effects is lower than that for haloperidol and risperidone. Somnolence may also occur, and appears to be somewhat dose-dependent when examining rates of this among patients receiving asenapine for schizophrenia and bipolar disorder. Prolactin elevation can occur, but at a rate lower than that observed for haloperidol or risperidone. Unique to asenapine is the possibility of oral hypoesthesia, occurring in about 5% of participants in the clinical trials. Obstacles to the use of asenapine are the recommendations for twice-daily dosing and the need to avoid food or liquids for 10 minutes after administration, although the bioavailability is only minimally reduced if food or liquids are avoided for only two minutes.Keywords: antipsychotic, asenapine, clinical trials, schizophrenia

  7. Clinical Genetic Testing of Periodic Fever Syndromes

    Directory of Open Access Journals (Sweden)

    Annalisa Marcuzzi

    2013-01-01

    Full Text Available Periodic fever syndromes (PFSs are a wide group of autoinflammatory diseases. Due to some clinical overlap between different PFSs, differential diagnosis can be a difficult challenge. Nowadays, there are no universally agreed recommendations for most PFSs, and near half of patients may remain without a genetic diagnosis even after performing multiple-gene analyses. Molecular analysis of periodic fevers’ causative genes can improve patient quality of life by providing early and accurate diagnosis and allowing the administration of appropriate treatment. In this paper we focus our discussion on effective usefulness of genetic diagnosis of PFSs. The aim of this paper is to establish how much can the diagnostic system improve, in order to increase the success of PFS diagnosis. The mayor expectation in the near future will be addressed to the so-called next generation sequencing approach. Although the application of bioinformatics to high-throughput genetic analysis could allow the identification of complex genotypes, the complexity of this definition will hardly result in a clear contribution for the physician. In our opinion, however, to obtain the best from this new development a rule should always be kept well in mind: use genetics only to answer specific clinical questions.

  8. Permeability relation for periodic structures.

    Science.gov (United States)

    Dunn, K J; LaTorraca, G A; Bergman, D J

    1998-01-01

    The permeability relation for periodic porous media is studied with respect to other petrophysical parameters such as formation factor, porosity, surface-to-volume ratio, and nuclear magnetic resonance (NMR) relaxation time. All these quantities were computed for periodic structures of simple, body-centered, and face-centered cubic arrays of touching and overlapping spheres. The formation factors were calculated by using a method which is based on a Fourier-space representation of an integral equation for the electric potential in a two-component composite. The nuclear magnetic resonance relaxation time for the case where surface-enchanced relaxation plays a dominant role is known to be V P/rho S (VP is the pore volume, S is the pore surface, is the surface relaxation strength) when rho is not too large. Previously calculated permeabilities for these structures from the literature were used for correlation studies with other petrophysical parameters. Various correlation schemes among these quantities, such as k = aTbFc, and k = aTb phi c, were investigated, where k is permeability, T is the NMR relaxation time, phi is the porosity, and F is the formation factor. PMID:9803908

  9. A Periodic Lotka-Volterra System

    OpenAIRE

    Tsvetkov, D.

    1996-01-01

    In this paper periodic time-dependent Lotka-Volterra systems are considered. It is shown that such a system has positive periodic solutions. It is done without constructive conditions over the period and the parameters.

  10. Psychiatric disorders in chronic periodic haemodialysis

    Directory of Open Access Journals (Sweden)

    Paraskevi Theofilou

    2010-10-01

    Full Text Available The progress in Medical and Nursing Science has contributed significantly to the lengthening of life expectancy regarding several categories of ill people with chronic diseases. However, when the quality of life depends on the periodic correction of biological parameters, as with people with chronic renal failure, this situation affects both the patient and the environment. The aim of the present study is the evaluation of psychiatric disorders which are presented in haemodialysis patients as well as the influence of these disorders on their quality of life. Material and method: Review of relative bibliography was made in electronic basis of Medline (1980‐2009 using as key words haemodialysis, chronic renal failure, quality of life, psychiatric disorders. Complementary bibliography was found through other electronic search engines. Results: The chronic character and the frequency of renal failure, the possible dysfunction in the movement as well as the necessary long treatment cause problems, which extend the disease beyond the medical area offering socioeconomic dimensions, which complicate the associated psychiatric disorders. Conclusions: These patients suffer from the disease as well as from the treatment and at the same time they are faced with the number of the accompanying and interrelated problems, which come up in their everyday living and prescribe restrictively their way of life.

  11. The clinical research of tension-free repair treatment inguinal hernia without use of antibiotics in the perioperative period%无张力腹股沟疝修补术在围术期不使用抗生素的临床研究

    Institute of Scientific and Technical Information of China (English)

    罗国德; 曹永宽; 张林; 张国虎; 王培红; 龚加庆; 王永华

    2013-01-01

    Objective To explore the feasibility and safety of tension-free repair treatment of inguinal hernia no use of antibiotics in the perioperative period. Methods The same including standards and double-blind randomized control study were carried out to compare the postoperative hospital stay and condition of operative incision in 59 patients who underwent tension-free hernia repair for inguinal hernia from February 2011 to October 2011. Among them, 29 patients without use of antibiotics were included in study group, and 30 patients who use of antibiotics were included in control group. Results All cases were cured completely. Compared with the control group, postoperative hospital stay was not significantly different between the two groups (P >0.05). Postoperative follow-up from 5 to 15 days, 3 cases lost to follow-up, 1 case appear fat liquefaction and surgical site infection in incision for per group, and are cured by change a medical prescription at outpatient department (P > 0.05) were not significantly different between the two groups. Operative incision class A healing were 27 cases vs 28 cases (P > 0.05) and were not significantly different between the two groups. Conclusion It is safety and feasible fortension-free hernia repair treatment inguinal hernia which may not use of antibiotics in the perioperative period, but should pay attention to the choice of case.%目的 探讨无张力疝修补术治疗腹股沟疝在围术期不使用抗生素的可行性和安全性.方法 采用统一入组标准,同期临床对比研究方法,对应用无张力疝修补术治疗59例腹股沟疝临床资料进行分析,其中以围术期未使用抗生素29例作为观察组,在围术期常规使用抗生素30例作为对照组,比较术后住院时间及手术切口愈合情况.结果 两组病例全部治愈,观察组术后住院时间为(3.41±0.94)d,对照组术后住院时间为(3.27±0.68)d,组间差异无统计学意义(P>0.05);术后5~15d随访,3例失访,观

  12. Structural Group Psychotherapy in the Treatment of Schizophrenia During Rehabilitation Period:Clinical Observation of 82 Cases%82例结构式团体心理治疗在精神分裂症康复期的效果观察

    Institute of Scientific and Technical Information of China (English)

    陈波; 张集慧; 鲁建瑞

    2015-01-01

    目的:进一步对结构式团体心理治疗在精神分裂症康复期的效果进行观察。方法:选取我院于2012年至2014年期间收治的164例精神分裂症,分成对照组和观察组,每组各82例,对照组患者采用药物治疗,同时进行适当的康复训练,观察组患者在对照组的基础上联合结构式团体心理治疗,采用住院慢性精神病患者社会功能评定量表、自尊量表、自我和谐量表对两组患者的治疗效果进行检验。结果:经过治疗后,观察组社会功能评定量表得分以及自我和谐量表得分均低于对照组,自尊量表得分明显高于对照组,两组差异明显(P<0.05),具有统计学意义。结论:在精神分裂症康复期患者的治疗过程中,结构式团体心理治疗法能够有效改善患者的社会功能,有利于患者的康复,具有极为重要的意义,今后值得推广和应用。%Objective: To further explore the clinical effects of structural group psychotherapy in patients with schizophrenia during rehabilitation period. Methods: 164 cases that were diagnosed with schizophrenia from 2012 to 2014 were randomly di-vided into a control group and an observation group, with 82 in each group each. Besides the drug therapy and appropriate reha-bilitation training which were implemented with the control group, structural group psychotherapy was also carried out on the ob-servation group. Social function assessment table, self-esteem volume table and self-harmony volume table were used for the testing of the clinical effects of hospitalized chronic psychiatric patients in the two groups. Results:After treatment, the scores of social function assessment table and self-harmony volume table in the observation group were lower than those of the control group. However, the self-esteem scale score of the observation group is significantly higher than that of the control group. Sig-nificant difference was observed in both

  13. A model for periodic blazars

    CERN Document Server

    Sobacchi, Emanuele; Stamerra, Antonio

    2016-01-01

    We describe a scenario to explain blazar periodicities with timescales of $\\sim$ few years. The scenario is based on a binary super-massive black hole (SMBH) system in which one of the two SMBH carries a jet. We discuss the various mechanisms that can cause the jet to precess and produce corkscrew patterns through space with a scale of $\\sim$ few pc. It turns out that the dominant mechanism responsible for the precession is simply the imprint of the jet-carrying SMBH orbital speed on the jet. Gravitational deflection and Lense-Thirring precession (due to the gravitational field of the other SMBH) are second order effects. We complement the scenario with a kinematical jet model which is inspired to the spine-sheath structure observed in M87. One of the main advantages of such a structure is that it allows the peak of the synchrotron emission to scale with frequency according to $\

  14. The periodically oscillating plasma sphere

    International Nuclear Information System (INIS)

    A new method of operating an inertial electrostatic confinement (IEC) device is proposed, and its performance is evaluated. The scheme involved an oscillating thermal cloud of ions immersed in a bath of electrons that form a harmonic oscillator potential. The scheme is called the periodically oscillating plasma sphere, and it appears to solve many of the problems that may limit other IEC systems to low gain. A set of self-similar solutions to the ion fluid equations is presented, and plasma performance is evaluated. Results indicate that performance enhancement of gridded IEC systems such as the Los Alamos intense neutron source device is possible as well as high-performance operation for low-loss systems such as the Penning trap experiment. Finally, a conceptual idea for a massively modular Penning trap reactor is also presented

  15. Spontaneous periodic hypothermia and hyperhidrosis.

    Science.gov (United States)

    Dundar, Nihal Olgac; Boz, Adil; Duman, Ozgur; Aydin, Funda; Haspolat, Senay

    2008-12-01

    We present a patient diagnosed with Shapiro syndrome without corpus callosum agenesis. A 4-year-old-girl was admitted to the hospital with complaints of sweating, cooling, and drowsiness that continued during the last week of her admission. Attacks occurred almost daily, and lasted for about 1 hour. All laboratory findings, as well as Holter and echocardiography results, were normal. Cranial magnetic resonance imaging demonstrated an intact corpus callosum, and electroencephalography obtained during an attack revealed normal findings. However, technetium 99m-labeled hexamethylpropylene amine oxime brain single-photon emission computed tomography indicated increased perfusion in the right thalamus, basal ganglia, and inferior frontal areas during a hypothermic period. Although oxcarbazepine reduced the frequency of attacks, they were not halted completely. The patient responded better to carbamazepine. PMID:19027594

  16. Quasi Periodic Oscillations in Blazars

    Indian Academy of Sciences (India)

    Alok C. Gupta

    2014-09-01

    Here we report our recent discoveries of Quasi-Periodic Oscillations (QPOs) in blazars time series data in X-ray and optical electromagnetic bands. Any such detection can give important clues of the location and nature of the processes of emission mechanism. In the case of radio-quiet AGN, the detected QPOs are very likely to be associated with the accretion disk. But in the case of blazars, it may be associated with jets in the high and outburst states, and in the low-state, it is probably associated with the accretion disk. In this brief review, I summarize the recent QPO detections in blazars. There is one strong evidence of QPO detection in XMM–Newton time series data of narrow line Seyfert 1 galaxy RE J1034+396 about which we will also discuss briefly.

  17. Double-blind evaluation of clonazepam on periodic leg movements in sleep.

    OpenAIRE

    Peled, R.; Lavie, P.

    1987-01-01

    Treatment with clonazepam was studied in a group of 20 patients suffering from periodic movements in sleep, in a double-blind parallel group design. Eleven complained of excessive daytime sleepiness, and nine complained of insomnia. Ten patients received clonazepam, and 10 received placebo, over a period of 1 month. Clonazepam (0.5-2 mg per night) proved to be an effective treatment of periodic movements in sleep. Polysomnographic recordings demonstrated a significant decrease in the number o...

  18. Controlling Subclinical Mastitis by Antibiotic Application during Dry Period of Dairy Cow

    OpenAIRE

    Imas Sri Nurhayati; E Martindah

    2015-01-01

    Prevention of mastitis is essential, as one of the efforts to control disease in dairy cow. Dry period has implications to understand the mastitis and its control strategies. The udder is very susceptible to be infected both at the beginning and towards the end of dry period. This is linked to physiological changes in udder. Treatment with antibiotics during the dry period can reduce new infection about 82% and has several advantages. The success rate of subclinical mastitis treatment is much...

  19. Impact of dietary plane of energy during the dry period on lipoprotein parameters in the transition period in dairy cattle.

    Science.gov (United States)

    Newman, A; Mann, S; Nydam, D V; Overton, T R; Behling-Kelly, E

    2016-02-01

    The high energy demands of dairy cows during the transition period from late gestation into early lactation can place them at an increased risk for the development of metabolic and infectious diseases. Modification of the dry period diet has been investigated as a preventive means to minimize the detrimental aspects of metabolic shifts during the transition period. Studies investigating the impact of dry period diet on lipid parameters during the transition period have largely focused on markers of lipolysis and ketogenesis. Total cholesterol declines during the periparturient period and increases in early lactation. The impact total energy in the dry period diet has on the ability of the cow to maintain total serum cholesterol, as well as its natural high-density lipoprotein-rich status, during this metabolically challenging window is not clear. The impact of lipoproteins on inflammation and immune function may have a clinical impact on the cow's ability to ward off production-related diseases. In this study, we hypothesized that the provision of adequate, but not excessive, total metabolizable energy, would better allow the cow to maintain total cholesterol and a higher relative proportion of HDL throughout the transition period. Cows were allocated to one of three dry period dietary treatment groups following a randomized block design. Total serum triglycerides, cholesterol and lipoprotein fractions were measured on a weekly basis from approximately 7 weeks pre-calving to 6 weeks post-calving. The cows on the high energy diet maintained total serum cholesterol as compared to the cows provided a lower energy diet, but there was no significant increase in the LDL fraction of lipoproteins between diet treatment groups. PMID:25958934

  20. 46 CFR 9.8 - Broken periods.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Broken periods. 9.8 Section 9.8 Shipping COAST GUARD... § 9.8 Broken periods. In computing extra compensation where the services rendered are in broken periods and less than 2 hours intervene between such broken periods the time served should be...

  1. Time—periodic weak solutions

    Directory of Open Access Journals (Sweden)

    Eliana Henriques de Brito

    1990-01-01

    Full Text Available In continuing from previous papers, where we studied the existence and uniqueness of the global solution and its asymptotic behavior as time t goes to infinity, we now search for a time-periodic weak solution u(t for the equation whose weak formulation in a Hilbert space H isddt(u′,v+δ(u′,v+αb(u,v+βa(u,v+(G(u,v=(h,vwhere: ′=d/dt; (′ is the inner product in H; b(u,v, a(u,v are given forms on subspaces U⊂W, respectively, of H; δ>0, α≥0, β≥0 are constants and α+β>0; G is the Gateaux derivative of a convex functional J:V⊂H→[0,∞ for V=U, when α>0 and V=W when α=0, hence β>0; v is a test function in V; h is a given function of t with values in H.

  2. Periodical plane puzzles with numbers

    CERN Document Server

    Rezende, Jorge

    2011-01-01

    Consider a periodical (in two independent directions) tiling of the plane with polygons (faces). In this article we shall only give examples using squares, regular hexagons, equilateral triangles and parallelograms ("unions" of two equilateral triangles). We shall call some "multiple" of the fundamental region "the board". We naturally identify pairs of corresponding edges of the the board. Figures 9 and 19-29, in this article, show different boards. The "border" of the board is represented by a yellow thick line, unless part of it or all of it is the edge of a face. The board is tiled by a finite number of polygons. Construct polygonal plates in the same number, shape and size as the polygons of the board. Adjacent to each side of each plate draw a number, or two numbers, like it is shown in Figures 1 and 18-29. Figure 1 shows the obvious possibility of having plates with simple drawings, coloured drawings, etc. Now the game is to put the plates over the board polygons in such a way that the numbers near eac...

  3. Periodic and Almost Periodic Solutions of Functional Difference Equations with Finite Delay

    OpenAIRE

    Yihong Song

    2007-01-01

    For periodic and almost periodic functional difference equations with finite delay, the existence of periodic and almost periodic solutions is obtained by using stability properties of a bounded solution.

  4. Critical Period of Weed Control in Aerobic Rice

    Directory of Open Access Journals (Sweden)

    M. P. Anwar

    2012-01-01

    Full Text Available Critical period of weed control is the foundation of integrated weed management and, hence, can be considered the first step to design weed control strategy. To determine critical period of weed control of aerobic rice, field trials were conducted during 2010/2011 at Universiti Putra Malaysia. A quantitative series of treatments comprising two components, (a increasing duration of weed interference and (b increasing length of weed-free period, were imposed. Critical period was determined through Logistic and Gompertz equations. Critical period varied between seasons; in main season, it started earlier and lasted longer, as compared to off-season. The onset of the critical period was found relatively stable between seasons, while the end was more variable. Critical period was determined as 7–49 days after seeding in off-season and 7–53 days in main season to achieve 95% of weed-free yield, and 23–40 days in off-season and 21–43 days in main season to achieve 90% of weed-free yield. Since 5% yield loss level is not practical from economic view point, a 10% yield loss may be considered excellent from economic view point. Therefore, aerobic rice should be kept weed-free during 21–43 days for better yield and higher economic return.

  5. Incontinence Treatment: Newer Treatment Options

    Science.gov (United States)

    ... Bowel Incontinence Signs & Symptoms Symptoms of Incontinence Diarrhea Treatment Lifestyle Changes Dietary Tips Medication Bowel Management Biofeedback Surgical Treatments Newer Treatment Options Tips on Finding a Doctor ...

  6. Periodic Poisson Solver for Particle Tracking

    CERN Document Server

    Dohlus, M

    2015-01-01

    A method is described to solve the Poisson problem for a three dimensional source distribution that is periodic into one direction. Perpendicular to the direction of periodicity a free space (or open) boundary is realized. In beam physics, this approach allows to calculate the space charge field of a continualized charged particle distribution with periodic pattern. The method is based on a particle mesh approach with equidistant grid and fast convolution with a Green's function. The periodic approach uses only one period of the source distribution, but a periodic extension of the Green's function. The approach is numerically efficient and allows the investigation of periodic- and pseudo-periodic structures with period lengths that are small compared to the source dimensions, for instance of laser modulated beams or of the evolution of micro bunch structures. Applications for laser modulated beams are given.

  7. Controlling Subclinical Mastitis by Antibiotic Application during Dry Period of Dairy Cow

    Directory of Open Access Journals (Sweden)

    Imas Sri Nurhayati

    2015-06-01

    Full Text Available Prevention of mastitis is essential, as one of the efforts to control disease in dairy cow. Dry period has implications to understand the mastitis and its control strategies. The udder is very susceptible to be infected both at the beginning and towards the end of dry period. This is linked to physiological changes in udder. Treatment with antibiotics during the dry period can reduce new infection about 82% and has several advantages. The success rate of subclinical mastitis treatment is much higher (80-90% compared to the treatment during lactation (30-40%; the doses of antibiotic can be higher and safer, due to its retention time in udder becomes longer; the risk of antibiotic contamination in milk can be avoided because the udder is not milked. Antibiotic application during dry period is the best way to treat subclinical and chronic mastitis. Treatment during dry period is a specific mastitis control for intramammary infection to avoid economic losses.

  8. Crystallography beyond periodic Crystal perfection

    International Nuclear Information System (INIS)

    Full text: The discovery of the quasi-crystals [D. Schechtman et. Al., Phys.] Rev. Lett. [53, 1951-1953 (1984)] made very narrow definition of the crystalline state based on the periodicity of a local arrangement of atoms. Since the definition of this State has been a matter of much controversy [G.R. Desiraju, Nature 423, 485 (2003); S. van Smaalen, IUCR Aperiodic Commission Reports. August 7, 2002; International Union of Crystallography. Report of the Executive Committee for 1991; ACTA Cryst. A48, 922-946 (1992)]. We will make a presentation of the current time of the crystallography in this regard from the conceptual point of view. We show the use of the formalism of algorithmic complexity or Kolmogorov [M. Li and P. Vitanyi, An Introduction to Kolmogorov Complexity and Its Applications (Springer Verlag, Heidelberg, 1993), W.H. Zurek, Phys.] Rev. 40, 4731 (1989); Nature 341, 119-124 (1989)] provides a different perspective on the nature of the Crystallographic order. Infinite crystals can be considered solid with zero algorithmic complexities by atom. Show statistical analysis of inorganic compounds [J.L.C. Daams et al., Atlas of Crystal Structure Types for Intermetallic Phases (ASM International, Ohio, 1991), Fachinformationszentrum/NIST Inorganic Crystal Structure Database, Karlsruhe (2003) icsd.fkf.mpg.de] demonstrating that the minimization of complexity is a trend in the crystalline arrangement. We will then compare the degree of disorder of some typical solids according to their algorithmic complexity. Finally, space diffraction will be studied from this same perspective and will be discussed that zero algorithmic complexities by point in space of diffraction does not necessarily imply the same thing for the Atomic arrangement. The discrete portion of the diffraction pattern is a fingerprint of the underlying order but not the actual existence of long-range order. Experimental results will be showcased [E. Estévez-Rams et al., Physical Review B, 63 (2001

  9. Thyrotoxic Periodic Paralysis: A Case Report and Literature Review

    Science.gov (United States)

    Barahona, M. J.; Vinagre, I.; Sojo, L.; Cubero, J. M.; Pérez, Antonio

    2009-01-01

    We describe a 37-year-old man with a 4-month history of episodic muscular weakness, involving mainly lower-limbs. Hypokalemia was documented in one episode and managed with intravenous potassium chloride. Hyperthyroidism was diagnosed 4 months after onset of attacks because of mild symptoms. The patient was subsequently diagnosed as having thyrotoxic periodic paralysis associated with Graves’ disease. Treatment with propranolol and methimazol was initiated and one year later he remains euthyroid and symptom free. Thyrotoxic periodic paralysis is a rare disorder, especially among Caucasians, but it should always be considered in patients with acute paralysis and hypokalemia, and thyroid function should be evaluated. PMID:19625499

  10. Safety and efficacy of ospemifene for the treatment of dyspareunia associated with vulvar and vaginal atrophy due to menopause.

    Science.gov (United States)

    Wurz, Gregory T; Kao, Chiao-Jung; DeGregorio, Michael W

    2014-01-01

    During the menopausal transition, women experience a number of symptoms due to declining estrogen levels, including vasomotor symptoms and vulvar and vaginal atrophy (VVA). Unlike vasomotor symptoms, vaginal dryness and dyspareunia, the main symptoms of VVA, typically worsen without treatment and can significantly impact the quality of life. Up to 60% of postmenopausal women may be affected by VVA, but many women unfortunately do not seek treatment due to embarrassment or other factors. After 20+ years in development, ospemifene (Osphena™) was approved by the US Food and Drug Administration in 2013 for treatment of moderate-to-severe dyspareunia associated with VVA due to menopause. As the first non-hormonal alternative to estrogen-based products for this indication, the approval of ospemifene represents a significant milestone in postmenopausal women's health. Ospemifene is a non-steroidal estrogen receptor agonist/antagonist, also known as a selective estrogen receptor modulator (SERM), from the same chemical class as the breast cancer drugs tamoxifen and toremifene. Unlike other selective estrogen receptor modulators, ospemifene exerts a strong, nearly full estrogen agonist effect in the vaginal epithelium, making it well suited for the treatment of dyspareunia in postmenopausal women. Results of Phase III clinical trials showed that ospemifene significantly improved the vaginal maturation index (decreased parabasal cells and increased superficial cells), decreased vaginal pH, and decreased severity of the self-identified most bothersome symptom (dyspareunia or vaginal dryness) compared to placebo. Long-term safety studies revealed that 60 mg ospemifene given daily for 52 weeks was well tolerated and was not associated with any endometrium or breast-related safety concerns. This review discusses the preclinical and clinical data supporting the use of ospemifene for the treatment of dyspareunia associated with VVA due to menopause and provides an overview of

  11. Effects of synaptophysin on plasticity of visual cortex neurons after rich environment and reverse suture treatment in critical period%丰富环境及反转缝合治疗后突触素对关键期内视皮质神经元可塑性的影响

    Institute of Scientific and Technical Information of China (English)

    蔺静静; 刘向玲; 王圆月; 宋子宣; 李靳; 张锐

    2015-01-01

    Objective To investigate the expression of synaptophysin (SYP) and its effects on plasticity of neurous in the visual cortex of monocularly deprived rats before and after reverse suture combined with enriched environment treatment in the critical period.Methods Thirty-six 14-day-old rats were randomly divided into six groups,6 cases in each group,in which normal control group I (NCI group) and normal control group Ⅱ (NCII group) were the normal control group,the right eyelid of rats in monocular deprivation group Ⅰ (MDI group),monocular deprivation group Ⅱ (MDII group),reverse suture group (RS group) and RS + enriched environment group (RS + EE group) were sutured,the eyelid of 28-day-old rats in RS group and RS + EE group were opened,then the other side eyelid were sutured.The rats in RS group were bred in the normal environment,and RS + EE group bred in EE.The pattern visual evoked potential of 28-day-old rats in NCI group and MDI group,42-day-old rats in NCII group,MDII group,RS group and RS + EE group were measured,and the expression of SYP protein in the visual cortex of the different groups were detected by immunohistochemistry staining and HE staining.Results The pattern visual evoked potential showed that the stability of P100 wave in the deprived eye was poor,the latency was increased,and the amplitude was decreased.The HE staining showed that the visual cortex neurons of rats in each group unchanged.The immunohistochemical staining showed that:The density of positive neurons of SYP in the visual cortex of RS group was significantly higher than those in MDII group,RS + EE group was higher than MDII group and RS group,MDII group was lower than NCI group,MDII group and RS group were lower than MDII group and RS + EE group; The quantitative analysis showed that,except for NCII group and RS + EE group,there were statistical differences in density of positive neurons between each other two groups (all P < 0.05).Conclusion SYP affect the plasticity of

  12. Influences of different control periods and coexistence with weed in eucalyptus

    Directory of Open Access Journals (Sweden)

    Eduardo Kneipp Londero

    2012-09-01

    Full Text Available This work studied the periods of control and coexistence of weeds with eucalyptus culture. The experiment was led in Candiota, RS, in the period from January to December, 2006. The treatments consisted of different control times and coexistence of the culture, these periods were divided in two groups; one was to determine the Period Previous to the Interference (PPI and the other to define the Total Period of Prevention of the Interference (TPFI. In the two groups the tested periods were: 00, 28, 56, 84, 112, 140, 168, 210, 252, 294 and 336 days. The young trees of eucalyptus were susceptible to weed, presenting a period previous to the interference of 56 days. In order to guarantee its largest production, the total period of prevention of the interference was 140 days and the period previous to the interference was of 56 days.

  13. 7 CFR 1205.20 - Representative period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Representative period. 1205.20 Section 1205.20 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... period means the 2006 calendar year....

  14. Financial Innovation in Multi-Period Economies

    OpenAIRE

    Enrique Kawamura

    2003-01-01

    I present an attempt to construct multi-period, finite horizon extensions to the well -known two- period financial innovations literature. I first extend the definition of competitive equilibrium with innovations. It is shown that, with a dominating house

  15. Periodic solutions of nonlinear vibrating beams

    Directory of Open Access Journals (Sweden)

    J. Berkovits

    2003-01-01

    Full Text Available The aim of this paper is to prove new existence and multiplicity results for periodic semilinear beam equation with a nonlinear time-independent perturbation in case the period is not prescribed. Since the spectrum of the linear part varies with the period, the solvability of the equation depends crucially on the period which can be chosen as a free parameter. Since the period of the external forcing is generally unknown a priori, we consider the following natural problem. For a given time-independent nonlinearity, find periods T for which the equation is solvable for any T-periodic forcing. We will also deal with the existence of multiple solutions when the nonlinearity interacts with the spectrum of the linear part. We show that under certain conditions multiple solutions do exist for any small forcing term with suitable period T. The results are obtained via generalized Leray-Schauder degree and reductions to invariant subspaces.

  16. US Forest Service Periodical Cicada Broods

    Data.gov (United States)

    US Forest Service, Department of Agriculture — A map service on the www depicting periodical cicada distribution and expected year of emergence by cicada brood and county. The periodical cicada emerges in...

  17. Genetics Home Reference: hypokalemic periodic paralysis

    Science.gov (United States)

    ... paralysis Patient Support and Advocacy Resources (2 links) Muscular Dystrophy Association Resource list from the University of Kansas Medical Center GeneReviews (1 link) Hypokalemic Periodic Paralysis Genetic Testing Registry (3 links) Hypokalemic periodic paralysis Hypokalemic ...

  18. Periodic Solution of the Hematopoiesis Equation

    Directory of Open Access Journals (Sweden)

    Ji-Huan He

    2013-01-01

    Full Text Available Wu and Liu (2012 presented some results for the existence and uniqueness of the periodic solutions for the hematopoiesis model. This paper gives a simple approach to find an approximate period of the model.

  19. The Middle Islamic and Crusader Periods

    DEFF Research Database (Denmark)

    Walmsley, Alan George

    2008-01-01

    The book chapter presents a critical review of the archaeology of Jordan in the middle Islamic periods (8th - 17th centuries CE), presenting a new evaluation of settlement and culture in the period, and assesses the errors of past appraoches.......The book chapter presents a critical review of the archaeology of Jordan in the middle Islamic periods (8th - 17th centuries CE), presenting a new evaluation of settlement and culture in the period, and assesses the errors of past appraoches....

  20. The period functions' higher order derivatives

    CERN Document Server

    Sabatini, Marco

    2012-01-01

    We prove a formula for the $n$-th derivative of the period function $T$ in a period annulus of a planar differential system. For $n = 1$, we obtain Freire, Gasull and Guillamon formula for the period's first derivative \\cite{FGG}. We apply such a result to hamiltonian systems with separable variables and other systems. We give some sufficient conditions for the period function of conservative second order O.D.E.'s to be convex.

  1. 27 CFR 70.244 - Payroll period.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Payroll period. 70.244... Excise and Special (Occupational) Tax Limitations § 70.244 Payroll period. For purpose of determining the... established calendar period regularly used by the employer or other person levied upon for payroll or...

  2. 12 CFR 226.7 - Periodic statement.

    Science.gov (United States)

    2010-01-01

    ... and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM TRUTH... periodic rates apply to different types of transactions, the types of transactions to which the periodic... amount(s) of any other type of finance charge. If there is more than one periodic rate, the amount of...

  3. 32 CFR 552.80 - Suspension period.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Suspension period. 552.80 Section 552.80 National... Suspension period. All solicitation privileges suspended by installation commanders will be for a specific time. Normally, it will not exceed 2 years. When the suspension period expires, the agent may...

  4. 21 CFR 573.240 - Calcium periodate.

    Science.gov (United States)

    2010-04-01

    ... with calcium hydroxide or calcium oxide to form a substance consisting of not less than 60 percent by... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Calcium periodate. 573.240 Section 573.240 Food... Additive Listing § 573.240 Calcium periodate. The food additive calcium periodate may be safely used...

  5. 49 CFR 236.588 - Periodic test.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Periodic test. 236.588 Section 236.588..., Train Control and Cab Signal Systems Inspection and Tests; Locomotive § 236.588 Periodic test. Except as provided in § 236.586, periodic test of the automatic train stop, train control, or cab signal...

  6. 77 FR 73452 - Grace Period Study

    Science.gov (United States)

    2012-12-10

    ... Patent and Trademark Office Grace Period Study ACTION: Proposed collection; comment request. SUMMARY: The...Collection@uspto.gov . Include ``0651- 00xx Grace Period Study comment'' in the subject line of the message... are not fully understood. Few studies in the past ten years have dealt with the grace period, and...

  7. 5 CFR 9901.411 - Appraisal period.

    Science.gov (United States)

    2010-01-01

    ....411 Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS... PERSONNEL SYSTEM (NSPS) Performance Management § 9901.411 Appraisal period. (a) Except as provided in... period, an employee has not met the minimum period of performance, management may extend the...

  8. Local Extrema of Periodic Function's Wavelet Transform

    Institute of Scientific and Technical Information of China (English)

    FAN Qi-bin; SONG Xiao-yan

    2005-01-01

    The theory of detecting ridges in the modulus of the continuous wavelet transform is presented as well as reconstructing signal by using information on ridges. To periodic signal we suppose Morlet wavelet as basic wavelet, and research the local extreme point and extrema of the wavelet transform on periodic function for the collection of signal's instantaneous amplitude and period.

  9. 32 CFR 37.1325 - Periodic audit.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Periodic audit. 37.1325 Section 37.1325 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1325 Periodic audit. An audit of... awards. Appendix C to this part describes what such an audit may cover. A periodic audit of a...

  10. 10 CFR 603.1295 - Periodic audit.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Periodic audit. 603.1295 Section 603.1295 Energy... Used in this Part § 603.1295 Periodic audit. An audit of a participant, performed at an agreed-upon... an audit may cover. A periodic audit of a participant differs from an award-specific audit of...

  11. Second-order Green's function perturbation theory for periodic systems

    CERN Document Server

    Rusakov, Alexander A

    2015-01-01

    Despite recent advances, systematic quantitative treatment of the electron correlation problem in extended systems remains a formidable task. Systematically improvable Green's function methods capable of quantitatively describing weak and at least qualitatively strong correlations appear promising candidates for computational treatment of periodic systems. We present a periodic implementation of temperature-dependent self-consistent 2nd-order Green's function method (GF2), where the self-energy is evaluated in the basis of atomic orbitals. Evaluating the real-space self-energy in atomic orbitals and solving the Dyson equation in $\\mathbf{k}$-space are the key components of a computationally feasible algorithm. We apply this technique to the 1D hydrogen lattice - a prototypical crystalline system with a realistic Hamiltonian. By analyzing the behavior of the spectral functions, natural occupations, and self-energies, we claim that GF2 is able to recover metallic, band insulating, and at least qualitatively Mot...

  12. Suicide During Perinatal Period: Epidemiology, Risk Factors and Clinical Correlates

    Directory of Open Access Journals (Sweden)

    Laura Orsolini

    2016-08-01

    Full Text Available Perinatal period may pose a great challenge for the clinical management and treatment of psychiatric disorders in women. In fact, several mental illnesses can arise during pregnancy and/or following childbirth. Suicide and infanticide have been considered relatively rare events during the perinatal period. However, in some mental disorders (i.e. postpartum depression, bipolar disorder, postpartum psychosis, etc. have been reported a higher risk of suicidal ideation, suicide attempt or suicide. Therefore, a complete screening of mothers’ mental health should also take into account thoughts of suicide and thoughts about harming infants as well. Clinicians should carefully monitor and early identify related clinical manifestations, potential risk factors and alarm symptoms related to suicide. The present paper aims at providing a focused review about epidemiological data, risk and protective factors and an overview about the main clinical correlates associated with the suicidal behaviour during the pregnancy and postpartum period.

  13. Suicide during Perinatal Period: Epidemiology, Risk Factors, and Clinical Correlates.

    Science.gov (United States)

    Orsolini, Laura; Valchera, Alessandro; Vecchiotti, Roberta; Tomasetti, Carmine; Iasevoli, Felice; Fornaro, Michele; De Berardis, Domenico; Perna, Giampaolo; Pompili, Maurizio; Bellantuono, Cesario

    2016-01-01

    Perinatal period may pose a great challenge for the clinical management and treatment of psychiatric disorders in women. In fact, several mental illnesses can arise during pregnancy and/or following childbirth. Suicide has been considered a relatively rare event during the perinatal period. However, in some mental disorders (i.e., postpartum depression, bipolar disorder, postpartum psychosis, etc.) have been reported a higher risk of suicidal ideation, suicide attempt, or suicide. Therefore, a complete screening of mothers' mental health should also take into account thoughts of suicide and thoughts about harming infants as well. Clinicians should carefully monitor and early identify related clinical manifestations, potential risk factors, and alarm symptoms related to suicide. The present paper aims at providing a focused review about epidemiological data, risk factors, and an overview about the main clinical correlates associated with the suicidal behavior during the pregnancy and postpartum period. Practical recommendations have been provided as well. PMID:27570512

  14. A rare case of thyrotoxic periodic paralysis precipitated by hydrocortisone

    OpenAIRE

    Chakrabarti, Subrata

    2015-01-01

    Thyrotoxic periodic paralysis (TPP) is a rare, but serious condition characterized by acute paralytic attacks and hypokalemia in association with thyrotoxicosis. Although carbohydrate rich meals, strenuous exercise, alcohol, emotional stress are known precipitants of TPP, steroid treatment has rarely been reported to induce TPP. We report a case in which a patient with previously untreated Grave's disease developed TPP following administration of Intravenous hydrocortisone for control of seve...

  15. Baseline study of methane emission from open digesting tanks of palm oil mill effluent treatment.

    Science.gov (United States)

    Yacob, Shahrakbah; Hassan, Mohd Ali; Shirai, Yoshihito; Wakisaka, Minato; Subash, Sunderaj

    2005-06-01

    Anthropogenic release of greenhouse gases, especially CO2 and CH4 has been recognized as one of the main causes of global warming. Several measures under the Kyoto Protocol 1997 have been drawn up to reduce the greenhouse gases emission. One of the measures is Clean Development Mechanisms (CDM) that was created to enable developed countries to cooperate with developing countries in emission reduction activities. In Malaysia, palm oil industry particularly from palm oil mill effluent (POME) anaerobic treatment has been identified as an important source of CH4. However, there is no study to quantify the actual CH4 emission from the commercial scale wastewater treatment facility. Hence, this paper shall address the CH4 emission from the open digesting tanks in Felda Serting Hilir Palm Oil Mill. CH4 emission pattern was recorded for 52 weeks from 3600 m3 open digesting tanks. The findings indicated that the CH4 content was between 13.5% and 49.0% which was lower than the value of 65% reported earlier. The biogas flow rate ranged between 0.8l min(-1)m(-2) and 9.8l min(-1)m(-2). Total CH4 emission per open digesting tank was 518.9 kgday(-1). Relationships between CH4 emission and total carbon removal and POME discharged were also discussed. Fluctuation of biogas production was observed throughout the studies as a result of seasonal oil palm cropping, mill activities, variation of POME quality and quantity discharged from the mill. Thus only through long-term field measurement CH4 emission can be accurately estimated. PMID:15894045

  16. Clinical utility of dronabinol in the treatment of weight loss associated with HIV and AIDS

    Directory of Open Access Journals (Sweden)

    Badowski ME

    2016-02-01

    Full Text Available Melissa E Badowski,1 Sarah E Perez2 1Department of Pharmacy Practice, Section of Infectious Diseases Pharmacotherapy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA; 2Infectious Diseases Clinic, Tufts Medical Center, Boston, MA, USA Abstract: Since the beginning of the HIV/AIDS epidemic, weight loss has been a common complaint for patients. The use of various definitions defining HIV wasting syndrome has made it difficult to determine its actual prevalence. Despite the use of highly active antiretroviral therapy, it is estimated that the prevalence of HIV wasting syndrome is between 14% and 38%. HIV wasting syndrome may stem from conditions affecting chewing, swallowing, or gastrointestinal motility, neurologic disease affecting food intake or the perception of hunger or ability to eat, psychiatric illness, food insecurity generated from psychosocial or economic concerns, or anorexia due to medications, malabsorption, infections, or tumors. Treatment of HIV wasting syndrome may be managed with appetite stimulants (megestrol acetate or dronabinol, anabolic agents (testosterone, testosterone analogs, or recombinant human growth hormone, or, rarely, cytokine production modulators (thalidomide. The goal of this review is to provide an in-depth evaluation based on existing clinical trials on the clinical utility of dronabinol in the treatment of weight loss associated with HIV/AIDS. Although total body weight gain varies with dronabinol use (–2.0 to 3.2 kg, dronabinol is a well-tolerated option to promote appetite stimulation. Further studies are needed with standardized definitions of HIV-associated weight loss and clinical outcomes, robust sample sizes, safety and efficacy data on chronic use of dronabinol beyond 52 weeks, and associated virologic and immunologic outcomes. Keywords: dronabinol, weight loss, HIV/AIDS, HIV wasting syndrome, cachexia

  17. Baseline study of methane emission from open digesting tanks of palm oil mill effluent treatment.

    Science.gov (United States)

    Yacob, Shahrakbah; Hassan, Mohd Ali; Shirai, Yoshihito; Wakisaka, Minato; Subash, Sunderaj

    2005-06-01

    Anthropogenic release of greenhouse gases, especially CO2 and CH4 has been recognized as one of the main causes of global warming. Several measures under the Kyoto Protocol 1997 have been drawn up to reduce the greenhouse gases emission. One of the measures is Clean Development Mechanisms (CDM) that was created to enable developed countries to cooperate with developing countries in emission reduction activities. In Malaysia, palm oil industry particularly from palm oil mill effluent (POME) anaerobic treatment has been identified as an important source of CH4. However, there is no study to quantify the actual CH4 emission from the commercial scale wastewater treatment facility. Hence, this paper shall address the CH4 emission from the open digesting tanks in Felda Serting Hilir Palm Oil Mill. CH4 emission pattern was recorded for 52 weeks from 3600 m3 open digesting tanks. The findings indicated that the CH4 content was between 13.5% and 49.0% which was lower than the value of 65% reported earlier. The biogas flow rate ranged between 0.8l min(-1)m(-2) and 9.8l min(-1)m(-2). Total CH4 emission per open digesting tank was 518.9 kgday(-1). Relationships between CH4 emission and total carbon removal and POME discharged were also discussed. Fluctuation of biogas production was observed throughout the studies as a result of seasonal oil palm cropping, mill activities, variation of POME quality and quantity discharged from the mill. Thus only through long-term field measurement CH4 emission can be accurately estimated.

  18. Rest versus exercise as treatment for patients with low back pain and Modic changes. a randomized controlled clinical trial

    Directory of Open Access Journals (Sweden)

    Jensen Rikke K

    2012-02-01

    Full Text Available Abstract Background Clinical experience suggests that many patients with Modic changes have relatively severe and persistent low back pain (LBP, which typically appears to be resistant to treatment. Exercise therapy is the recommended treatment for chronic LBP, however, due to their underlying pathology, Modic changes might be a diagnostic subgroup that does not benefit from exercise. The objective of this study was to compare the current state-of-the art treatment approach (exercise and staying active with a new approach (load reduction and daily rest for people with Modic changes using a randomized controlled trial design. Methods Participants were patients from an outpatient clinic with persistent LBP and Modic changes. They were allocated using minimization to either rest therapy for 10 weeks with a recommendation to rest for two hours daily and the option of using a flexible lumbar belt or exercise therapy once a week for 10 weeks. Follow-up was at 10 weeks after recruitment and 52 weeks after intervention and the clinical outcome measures were pain, disability, general health and global assessment, supplemented by weekly information on low back problems and sick leave measured by short text message (SMS tracking. Results In total, 100 patients were included in the study. Data on 87 patients at 10 weeks and 96 patients at one-year follow-up were available and were used in the intention-to-treat analysis. No statistically significant differences were found between the two intervention groups on any outcome. Conclusions No differences were found between the two treatment approaches, 'rest and reduced load' and 'exercise and staying active', in patients with persistent LBP and Modic changes. Trial Registration ClinicalTrials.gov: NCT00454792

  19. The Cervical Cerclage Treatment of Cervical Insufficiency during Different Pregnancy Periods and the Impact on Pregnant Outcomes%不同孕期和不同治疗时机行宫颈环扎术治疗宫颈机能不全患者的效果及妊娠结局研究

    Institute of Scientific and Technical Information of China (English)

    王虹

    2016-01-01

    目的:探讨不同孕期和不同治疗时机行宫颈环扎术治疗宫颈机能不全患者的效果及妊娠结局。方法回顾性分析2010年3月至2014年10月安塞县人民医院收治的119例宫颈机能不全患者的临床资料,其中孕14~16周66例为妊娠早期组,孕17~28周53例为妊娠中期组;又根据入院后待择期行宫颈环扎术治疗78例为非紧急组,入院后行紧急手术治疗41例为紧急组。比较不同孕期、不同治疗时机行宫颈环扎术对妊娠结果的影响。结果妊娠早期组患者手术干预后足月生产率显著高于妊娠中期组[83.3%(55/66)比20.8%(11/53)],晚期流产率和宫内感染率显著低于妊娠中期组[10.0%(6/66)比68.0%(36/53),7.6%(5/66)比64.2%(34/53)],差异有统计学意义(P<0.05)。非紧急组手术干预治疗后足月生产率显著高于紧急组[71.8%(56/78)比24.4%(10/41)],晚期流产率和宫内感染率显著低于紧急组[20.5%(16/78)比63.4%(26/41),18.0%(14/78)比(61.0%(25/41)],差异有统计学意义(P <0.05)。妊娠早期组住院时间短于妊娠晚期组[(7.3±1.4) d 比(11.2±3.5) d],差异有统计学意义(P<0.05)。结论宫颈机能不全患者,应于妊娠14~16周择期行宫颈环扎术治疗;对于孕前宫颈机能不全诊断不明患者,伴早产史或晚期流产史的高危孕妇,在孕中期通过B型超声发现宫颈机能不全,应行紧急宫颈环扎治疗术,术后加强监测,预防感染,从而降低宫内感染率及晚期流产率;提高胎儿足月生产机会,最终达到改善妊娠结局的目的。%Objective To analyze the cervical cerclage treatment of cervical insufficiency during differ-ent pregnancy periods and the impact on pregnant outcomes.Methods One hundred and nineteen patients who had received cervical cerclage for cervical incompetence in

  20. 围手术期口服西地那非治疗成人先天性心脏病重度肺动脉高压%Treatment of severe pulmonary arterial hypertension with oral sildenafil in patients with congenital heart disease during perioperative period

    Institute of Scientific and Technical Information of China (English)

    刘洋; 陆方林; 蒋庚西; 李白翎; 李莉; 陈金强; 徐志云

    2014-01-01

    Objective To study the effects of oral sildenafil for the treatment of severe pulmonary arterial hypertension (PAH) in patients with congenital heart disease during perioperative period .Methods From August 2010 to August 2013, 42 patients (mean age of 31.2 ±16.1 years old) with congenital heart disease and severe PAH confirmed by base line assessment of cardiac cathe -terization, and with mean pulmonary artery pressure (MPAP)≥45mmHg, were chosen for the study.Of all the cases, 22 were atrial septal defect(ASD)cases, 12 were ventricular septal defect(VSD)cases and 8 were patent ductus arteriossus(PDA)cases.Oral silde-nafil at a dosage of 0.5mg/kg, 3 times a day, was administered to all the patients , 2 to 3 weeks before surgery .Then, changes in the hemodynamic parameters were observed and compared before and after medication .All the patients resumed medication , after circulato-ry stability was achieved.Then, 19 patients were placed Swan -Ganz catheter following anesthesia .Changes in mean pulmonary artery pressure (MPAP), mean artery pressure (MAP), MPAP/MAP, cardiac index (CI), pulmonary vascular resistance index (PVRI) and systemic vascular resistance index (SVRI) were observed and compared 0.5 h, 1h, 4h and 24h after medication following anesthe-sia.Results For the 42 patients, who received medication for (17.51 ±7.29) days before surgery , color cardiac ultrasonography indi-cated that systolic pulmonary artery pressure (SPAP) was (80.13 ±15.41)mmHg, which was significantly lower than that before medi-cation [(87.71 ±14.68)mmHg], with statistical significance(P <0.05).In the 19 patients who received floating catheter, MPAP and PVRI decreased significantly, 0.5 h, 1 h, 4 h and 24 h after medication, also with statistical significance(P <0.05).MAP was lower 0.5h after medication, when it was compared with that before medication , also with statistical significance(P <0.05).No statis-tical significance could be noted in SVRI and CI , when they were

  1. Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome.

    Science.gov (United States)

    Ali, Nora S; Sartori-Valinotti, Julio C; Bruce, Alison J

    2016-01-01

    Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome, the most common periodic disorder of childhood, presents with the cardinal symptoms of periodic fever, aphthous stomatitis, pharyngitis, and adenitis typically before age 5. This review presents the recent literature on PFAPA and summarizes key findings in the pathogenesis, evaluation, and treatment of the disease. Theories surrounding the pathogenesis of PFAPA include a faulty innate immunologic response in conjunction with dysregulated T-cell activation. A potential genetic link is also under consideration. Mediterranean fever (MEFV) gene variants have been implicated and appear to modify disease severity. In individuals with the heterozygous variant, PFAPA episodes are milder and shorter in duration. Diagnostic criteria include the traditional clinical signs, in addition to the following biomarkers: elevated C-reactive protein in the absence of elevated procalcitonin, vitamin D, CD64, mean corpuscular volume, and other nonspecific inflammatory mediators in the absence of an infectious explanation for fever. Treatment of PFAPA includes tonsillectomy, a single dose of corticosteroids, and, most recently, interleukin 1 blockers such as anakinra, rilonacept, and canakinumab. Tonsillectomy remains the only permanent treatment modality. PMID:27343963

  2. A highly specific test for periodicity

    Energy Technology Data Exchange (ETDEWEB)

    Ansmann, Gerrit, E-mail: gansmann@uni-bonn.de [Department of Epileptology, University of Bonn, Sigmund-Freud-Straße 25, 53105 Bonn (Germany); Helmholtz Institute for Radiation and Nuclear Physics, University of Bonn, Nussallee 14–16, 53115 Bonn (Germany); Interdisciplinary Center for Complex Systems, University of Bonn, Brühler Straße 7, 53175 Bonn (Germany)

    2015-11-15

    We present a method that allows to distinguish between nearly periodic and strictly periodic time series. To this purpose, we employ a conservative criterion for periodicity, namely, that the time series can be interpolated by a periodic function whose local extrema are also present in the time series. Our method is intended for the analysis of time series generated by deterministic time-continuous dynamical systems, where it can help telling periodic dynamics from chaotic or transient ones. We empirically investigate our method's performance and compare it to an approach based on marker events (or Poincaré sections). We demonstrate that our method is capable of detecting small deviations from periodicity and outperforms the marker-event-based approach in typical situations. Our method requires no adjustment of parameters to the individual time series, yields the period length with a precision that exceeds the sampling rate, and its runtime grows asymptotically linear with the length of the time series.

  3. Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites: A One-Year-Period Study in Rabbit Trochlea

    Directory of Open Access Journals (Sweden)

    Weijie Zhang

    2014-01-01

    Full Text Available Increasing evidences show that subchondral bone may play a significant role in the repair or progression of cartilage damage in situ. However, the exact change of subchondral bone during osteochondral repair is still poorly understood. In this paper, biphasic osteochondral composite scaffolds were fabricated by 3D printing technology using PEG hydrogel and β-TCP ceramic and then implanted in rabbit trochlea within a critical size defect model. Animals were euthanized at 1, 2, 4, 8, 16, 24, and 52 weeks after implantation. Histological results showed that hyaline-like cartilage formed along with white smooth surface and invisible margin at 24 weeks postoperatively, typical tidemark formation at 52 weeks. The repaired subchondral bone formed from 16 to 52 weeks in a “flow like” manner from surrounding bone to the defect center gradually. Statistical analysis illustrated that both subchondral bone volume and migration area percentage were highly correlated with the gross appearance Wayne score of repaired cartilage. Therefore, subchondral bone migration is related to cartilage repair for critical size osteochondral defects. Furthermore, the subchondral bone remodeling proceeds in a “flow like” manner and repaired cartilage with tidemark implies that the biphasic PEG/β-TCP composites fabricated by 3D printing provides a feasible strategy for osteochondral tissue engineering application.

  4. Cartilage repair and subchondral bone migration using 3D printing osteochondral composites: a one-year-period study in rabbit trochlea.

    Science.gov (United States)

    Zhang, Weijie; Lian, Qin; Li, Dichen; Wang, Kunzheng; Hao, Dingjun; Bian, Weiguo; He, Jiankang; Jin, Zhongmin

    2014-01-01

    Increasing evidences show that subchondral bone may play a significant role in the repair or progression of cartilage damage in situ. However, the exact change of subchondral bone during osteochondral repair is still poorly understood. In this paper, biphasic osteochondral composite scaffolds were fabricated by 3D printing technology using PEG hydrogel and β-TCP ceramic and then implanted in rabbit trochlea within a critical size defect model. Animals were euthanized at 1, 2, 4, 8, 16, 24, and 52 weeks after implantation. Histological results showed that hyaline-like cartilage formed along with white smooth surface and invisible margin at 24 weeks postoperatively, typical tidemark formation at 52 weeks. The repaired subchondral bone formed from 16 to 52 weeks in a "flow like" manner from surrounding bone to the defect center gradually. Statistical analysis illustrated that both subchondral bone volume and migration area percentage were highly correlated with the gross appearance Wayne score of repaired cartilage. Therefore, subchondral bone migration is related to cartilage repair for critical size osteochondral defects. Furthermore, the subchondral bone remodeling proceeds in a "flow like" manner and repaired cartilage with tidemark implies that the biphasic PEG/β-TCP composites fabricated by 3D printing provides a feasible strategy for osteochondral tissue engineering application.

  5. Gabor systems on discrete periodic sets

    Institute of Scientific and Technical Information of China (English)

    LI YunZhang; LIAN QiaoFang

    2009-01-01

    Due to its good potential for digital signal processing,discrete Gabor analysis has inter ested some mathematicians.This paper addresses Gabor systems on discrete periodic sets,which can model signals to appear periodically but intermittently.Complete Gabor systems and Gabor frames on discrete periodic sets are characterized; a sufficient and necessary condition on what periodic sets admit complete Gabor systems is obtained; this condition is also proved to be sufficient and necessary for the existence of sets E such that the Gabor systems generated by XE are tight frames on these periodic sets; our proof is constructive,and all tight frames of the above form with a special frame bound can be obtained by our method; periodic sets admitting Gabor Riesz bases are characterized;some examples are also provided to illustrate the general theory.

  6. Gabor systems on discrete periodic sets

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Due to its good potential for digital signal processing, discrete Gabor analysis has interested some mathematicians. This paper addresses Gabor systems on discrete periodic sets, which can model signals to appear periodically but intermittently. Complete Gabor systems and Gabor frames on discrete periodic sets are characterized; a sufficient and necessary condition on what periodic sets admit complete Gabor systems is obtained; this condition is also proved to be sufficient and necessary for the existence of sets E such that the Gabor systems generated by χE are tight frames on these periodic sets; our proof is constructive, and all tight frames of the above form with a special frame bound can be obtained by our method; periodic sets admitting Gabor Riesz bases are characterized; some examples are also provided to illustrate the general theory.

  7. Periodic boundary conditions on the pseudosphere

    OpenAIRE

    Sausset, François; Tarjus, Gilles

    2007-01-01

    30 pages, minor corrections, accepted to J. Phys. A International audience We provide a framework to build periodic boundary conditions on the pseudosphere (or hyperbolic plane), the infinite two-dimensional Riemannian space of constant negative curvature. Starting from the common case of periodic boundary conditions in the Euclidean plane, we introduce all the needed mathematical notions and sketch a classification of periodic boundary conditions on the hyperbolic plane. We stress the ...

  8. Cyclical period changes in Z Chamaeleontis

    CERN Document Server

    Baptista, R; Oliveira, E; Vrielmann, S; Woudt, P A; Catalan, M S

    2002-01-01

    We report the identification of cyclical changes in the orbital period of the eclipsing dwarf nova Z Cha. We used times of mid-eclipse collected from the literature and our new eclipse timings to construct an observed-minus-calculated diagram covering 30 years of observations (1972-2002). The data present cyclical variations that can be fitted by a linear plus sinusoidal function with period 28+/-2 yr and amplitude 1.0+/-0.2 minute. The statistical significance of this period by an F-test is larger than 99.9%. The derived fractional period change, Delta P/P= 4.4 x 10^{-7}, is comparable to that of other short-period cataclysmic variables (CVs), but is one order of magnitude smaller than those of the long-period CVs. Separate fits to the first and second half of the data lead to ephemerides with quite different cycle periods and amplitudes, indicating that the variation is not sinusoidal or, most probably, is not strictly periodic. The observed cyclical period change is possibly caused by a solar-type magnetic...

  9. Measuring Stellar Rotation Periods with Kepler

    DEFF Research Database (Denmark)

    Nielsen, M. B.; Gizon, L.; Schunker, H.;

    2012-01-01

    We measure rotation periods for 12151 stars in the Kepler field, based on photometric variability caused by stellar activity. Our analysis returns stable rotation periods over at least six out of eight quarters of Kepler data. This large sample of stars enables us to study rotation periods as a...... function of spectral type. We find good agreement with previous studies and v sin i measurements for F, G, and K stars. Combining rotation periods, (B-V) color, and gyrochronology relations, we find that cool stars in our sample are predominantly younger than ˜ 1 Gyr....

  10. Periodic boundary conditions on the pseudosphere

    Energy Technology Data Exchange (ETDEWEB)

    Sausset, F; Tarjus, G [Laboratoire de Physique Theorique de la Matiere Condensee, Universite Pierre et Marie Curie, Paris 6, UMR CNRS 7600, 4 place Jussieu, 75252 Paris Cedex 05 (France)

    2007-10-26

    We provide a framework for building periodic boundary conditions on the pseudosphere (or hyperbolic plane), the infinite two-dimensional Riemannian space of constant negative curvature. Starting from the common case of periodic boundary conditions in the Euclidean plane, we introduce all the required mathematical notions and sketch a classification of periodic boundary conditions on the hyperbolic plane. We stress the possible applications in statistical mechanics for studying the bulk behavior of physical systems, and illustrate how to implement such periodic boundary conditions in two examples, the dynamics of particles on the pseudosphere and the study of classical spins on hyperbolic lattices.

  11. Exact analysis of bi-periodic structures

    CERN Document Server

    Cai, C W; Chan, H C

    2002-01-01

    By using the U-transformation method, it is possible to uncouple linear simultaneous equations, either algebraic or differential, with cyclic periodicity. This book presents a procedure for applying the U-transformation technique twice to uncouple the two sets of unknown variables in a doubly periodic structure to achieve an analytical exact solution. Explicit exact solutions for the static and dynamic analyses for certain engineering structures with doubly periodic properties - such as a continuous truss with any number of spans, cable network and grillwork on supports with periodicity, and g

  12. The Prevalence and Incidence of Glaucoma in Denmark in a Fifteen Year Period

    DEFF Research Database (Denmark)

    Kolko, Miriam; Horwitz, Anna; Thygesen, John;

    2015-01-01

    PURPOSE: The purpose of the present study was to describe the prevalence, incidence and geographic variation of glaucoma in Denmark in the period from 1996 to 2011. Moreover, the aim was to identify the treatment patterns of glaucoma within the studied period. METHODS: All Danish citizens were in...

  13. 76 FR 31349 - Determination of Regulatory Review Period for Purposes of Patent Extension; ACTEMRA

    Science.gov (United States)

    2011-05-31

    ... treatment of rheumatoid arthritis. Subsequent to this approval, the Patent and Trademark Office received... HUMAN SERVICES Food and Drug Administration Determination of Regulatory Review Period for Purposes of... and Drug Administration (FDA) has determined the regulatory review period for ACTEMRA and...

  14. 20 CFR 404.321 - When a period of disability begins and ends.

    Science.gov (United States)

    2010-04-01

    ... period described in § 404.1592a, the last month for which you received benefits. (d) When drug addiction... the number of entitlement periods you may have had based on disability where drug addiction or... are months in which treatment for your drug addiction or alcoholism is not available, months...

  15. 77 FR 27125 - Periodicals-Recognition of Distribution of Periodicals via Electronic Copies

    Science.gov (United States)

    2012-05-09

    ... via Electronic Copies (77 FR 5470-5471) revising DMM 707.6 by adding optional reporting of electronic... 111 Periodicals--Recognition of Distribution of Periodicals via Electronic Copies AGENCY: Postal... copies of Periodicals publications to satisfy the circulation standards for Periodicals...

  16. 77 FR 5470 - Periodicals-Recognition of Distribution of Periodicals via Electronic Copies

    Science.gov (United States)

    2012-02-03

    ... 111 Periodicals--Recognition of Distribution of Periodicals via Electronic Copies AGENCY: Postal... the conditions that would allow electronic copies of Periodicals (e-pubs) to be counted with other... traditional printed copies of Periodicals to electronic copies of the same publications has grown....

  17. Competition and critical periods in spring sugar beet cultivation

    Directory of Open Access Journals (Sweden)

    Mansilla Martínez José

    2015-12-01

    Full Text Available High yields with low costs require that sugar beets be kept free of weeds, during critical periods, using labor or chemical treatments. Since the critical periods for this crop in Castilla - La Mancha (Spain are unknown, the first goal of this study was to determine the effect of early and late competition on yield. The second goal was to determine the critical periods, while taking into consideration the semiarid climatic conditions of this region. Two irrigation farms located in the province of Albacete are dedicated to sugar beet cultivation. These two farms were chosen to carry out the tests March (140,000-150,000 seeds ∙ ha-1 and harvested in October. Two simultaneous and complementary experiments were carried out in each year and farm. Two scenarios were considered with eight different treatments each. In the first one (With Weeds Until - WWU, plots were infested by weeds up to a certain date. In the second one (Free of Weeds Until - FWU, plots were kept free of weeds up to a certain date. For each test, a randomised experimental blocked field was designed and there were four repetitions, each of them containing eight elemental plots (12 m2. Each plot was weeded by hand or weeds were left to grow till a definite date.The results indicated that a 1% loss of yield was reached in the early competition after 14 days, while a loss of 5% was reached after a period of 41 days after it was infested. The results also indicated that in late competition, if a crop is kept clean for 124 days and it is infested afterwards, a 1% loss is reached. However, the loss increases to 5% if the plot is kept clean for 111 days. For a 1% loss the critical period is 110 days and 70 days for a 5% loss.

  18. Long-term efficacy and safety of ramosetron in the treatment of diarrhea-predominant irritable bowel syndrome

    Directory of Open Access Journals (Sweden)

    Chiba T

    2013-07-01

    Full Text Available Toshimi Chiba, Kazunari Yamamoto, Shoko Sato, Kazuyuki Suzuki Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Iwate, Japan Abstract: Irritable bowel syndrome (IBS is a functional disease with persisting gastrointestinal symptoms that has been classified into four subtypes. Serotonin (5-hydroxytryptamine [5-HT] plays important physiological roles in the contraction and relaxation of smooth muscle. Intraluminal distension of the intestine is known to stimulate the release of endogenous 5-HT from enterochromaffin cells, activating 5-HT3 receptors located on primary afferent neurons and leading to increases in intestinal secretions and peristaltic activity. Ramosetron, a potent and selective 5-HT3-receptor antagonist, has been in development for use in patients suffering from diarrhea-predominant IBS. In a double-blind, placebo-controlled, parallel-group study of 418 patients with diarrhea-predominant IBS-D, once-daily 5 µg and 10 µg doses of ramosetron increased the monthly responder rates of IBS symptoms compared to placebo. In a 12-week randomized controlled trial of 539 patients, a positive response to treatment was reported by 47% of a once-daily 5 µg dose of ramosetron-treated individuals compared to 27% of patients receiving placebo (P<0.001. Furthermore, the responder rate was increased in the oral administration of 5 µg of ramosetron for at least 28 weeks (up to 52 weeks, and long-term efficacy for overall improvement of IBS symptoms was also demonstrated. The rate was further increased subsequently. Adverse events were reported by 7% in ramosetron treatment. No serious adverse events, eg, severe constipation or ischemic colitis, were reported for long-term treatment with ramosetron. In conclusion, further studies to evaluate the long-term efficacy and safety of ramosetron are warranted in the form of randomized controlled trials. Keywords: long

  19. Vilazodone for the treatment of major depressive disorder: an evidence-based review of its place in therapy

    Directory of Open Access Journals (Sweden)

    Hellerstein DJ

    2015-04-01

    Full Text Available David J Hellerstein,1,2 Joseph Flaxer11Department of Psychiatry, Columbia University, 2New York State Psychiatric Institute, New York, NY, USAIntroduction: It has clearly been demonstrated that depressive disorders constitute a major worldwide public health problem, with massive economic and quality-of-life consequences. Existing pharmacological treatments have limited efficacy, with only about a third of patients achieving remission on any one medication. Delayed onset of action and variable tolerability contribute to this limited efficacy. Vilazodone, introduced in the US in 2011, has been described as the first member of the serotonin partial agonist-reuptake inhibitor (SPARI class of medications, combining serotonin-reuptake inhibition with 5-HT1A partial agonism. This agent could potentially have benefits for subgroups of depressed patients, including depressed patients with comorbid anxiety and patients with anxiety disorders, and might have fewer sexual side effects than selective serotonin-reuptake inhibitors (SSRIs.Aims: We reviewed existing clinical trials that assess the benefits of vilazodone for treatment of major depression.Evidence review: In clinical trials, including two Phase III studies and two Phase IV studies, vilazodone has been shown to have efficacy greater than placebo on the Montgomery–Åsberg Depression Rating Scale, comparable efficacy to citalopram, and continued benefit after 52 weeks of treatment. The safety profile for vilazodone is comparable to other SSRI medications, and tolerability also appears generally comparable to other SSRI medications.Place in therapy: Vilazodone, which has been described as the first-of-class SPARI medication, may potentially have benefits for subgroups of patients, particularly those depressed individuals with coexisting anxiety symptoms or anxiety disorders. However, convincing evidence for these benefits has as yet not been published.Keywords: vilazodone, antidepressant

  20. Profile of saxagliptin in the treatment of type 2 diabetes: focus on Japanese patients

    Directory of Open Access Journals (Sweden)

    Konya H

    2014-07-01

    Full Text Available Hiroyuki Konya,1 Yuzo Yano,1 Satoshi Matsutani,1 Taku Tsunoda,2 Takashi Ikawa,2 Yoshiki Kusunoki,2 Toshihiro Matsuo,2 Masayuki Miuchi,2 Tomoyuki Katsuno,3 Tomoya Hamaguchi,4 Jun-ichiro Miyagawa,2 Mitsuyoshi Namba21Department of Internal Medicine, Ashiya Municipal Hospital, Ashiya, 2Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, 3Division of Innovative Diabetes Treatment, Hyogo College of Medicine, Nishinomiya, 4Division of Diabetes, Department of Internal Medicine, Itami City Hospital, Itami, Hyogo, JapanAbstract: Saxagliptin is a selective and potent dipeptidyl peptidase (DPP-4 inhibitor, approved as an adjunct to diet and exercise to improve glycemic control in type 2 diabetes mellitus (T2DM in the USA on July 2009, and had been launched globally in over 86 countries by September 2013. In patients with T2DM, once-daily administration of saxagliptin before breakfast achieves sustained inhibition of plasma DPP-4 activity and reduction of postprandial hyperglycemia, including after dinner, associated with an increase in plasma glucagon-like peptide-1 levels. This paper reviews the safety and efficacy of saxagliptin in Japanese patients with T2DM. The clinical development study in Japan supported its usefulness for the disease. Saxagliptin 1, 2.5, and 5 mg led to significant improvements in glycated hemoglobin (HbA1c, and was generally well tolerated. Treatment with saxagliptin 5 mg induced a sustained reduction in HbA1c over 52 weeks. Long-term combination therapy with saxagliptin and other oral hypoglycemic agents also provided sustained glycemic control and was well tolerated for up to 52 weeks. Saxagliptin as add-on to sulfonylureas or glinides has a tendency to increase hypoglycemia, but not with other oral antidiabetic agents, such as α-glucosidase inhibitors, metformin, or thiazolidinediones. The results of clinical trials have confirmed the long-term efficacy and safety of saxagliptin monotherapy as

  1. 42 CFR 409.60 - Benefit periods.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Benefit periods. 409.60 Section 409.60 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM HOSPITAL INSURANCE BENEFITS Scope of Hospital Insurance Benefits § 409.60 Benefit periods. (a) When...

  2. How Sensitively Timed Are Sensitive Periods?

    Science.gov (United States)

    Zener, Rita Schaefer

    2003-01-01

    Reviews Maria Montessori's view of sensitive periods and examines the kinds of help needed from adults: an open mind, specific help from a prepared learning environment, and challenges presented at the right time. Stresses the universality of sensitive periods and their connection to brain development. Focuses on the unconscious nature and…

  3. 28 CFR 524.75 - Periodic review.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Periodic review. 524.75 Section 524.75... TRANSFER CLASSIFICATION OF INMATES Central Inmate Monitoring (CIM) System § 524.75 Periodic review. The Warden shall ensure that the status of an inmate's CIM assignment is considered at each program...

  4. 20 CFR 655.205 - Recruitment period.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Recruitment period. 655.205 Section 655.205... Agricultural Employment § 655.205 Recruitment period. (a) If the OFLC Administrator determines that the... carry out the assurances contained in § 655.203 with respect to the recruitment of U.S. workers....

  5. Short Periodicities in Latitudinal Variation of Sunspots

    Science.gov (United States)

    Kim, Bang-Yeop; Chang, Heon-Young

    2011-06-01

    The latitudinal variation of sunspots appearing during the period from 1874 to 2009 has been studied in terms of centerof- latitude (COL). The butterfly diagram has been used to study the evolution of the magnetic field and the dynamics at the bottom of the solar convection zone. Short-term periodicities have been of particular interest, in that they are somehow related to the structure and dynamics of the solar interior. We thus have focused our investigation on shortterm periodicities. We first calculated COL by averaging the latitude of sunspots with the weight function in area. Then, we analyzed the time series of COL using the wavelet transform technique. We found that a periodicity of ~5 years is the most dominant feature in the time series of COL, with the exception of the ~11 year solar cycle itself. This periodicity can be easily understood by considering small humps between the minima in the area-weighted butterfly diagram. However, we find that periodicities of ~1.3 (0.064), ~1.5 (0.056), or ~1.8 (0.046) years ( 1/ month ), which have been previously suggested as evidence of links between the changing structure of the sunspot zone and the tachocline rotation rate oscillations, are insignificant and inconsistent. We therefore conclude that the only existing short-term periodicity is of ~5 years, and that periodicities of ~1.3, ~1.5, or ~1.8 years are likely to be artifacts due to random noise of small sunspots.

  6. Lightcurve and period determination for 582 Olympia

    Science.gov (United States)

    Higgins, David; Menke, John; Pozzoli, Valentino; Sheridan, Edwin; Dymock, Roger

    2004-03-01

    Minor planet 582 Olympia was observed over a period of 40 days from 9 February to 20 March 2003. More than 3000 data points from 42 sessions were obtained by 5 observers. The lightcurve obtained shows a rotational (synodic) period of 72.0 ± 0.5 hrs with amplitude of 0.20 ± 0.05 mag.

  7. Online Periodic Table: A Cautionary Note

    Science.gov (United States)

    Izci, Kemal; Barrow, Lloyd H.; Thornhill, Erica

    2013-01-01

    The purpose of this study was (a) to evaluate ten online periodic table sources for their accuracy and (b) to compare the types of information and links provided to users. Limited studies have been reported on online periodic table (Diener and Moore 2011; Slocum and Moore in "J Chem Educ" 86(10):1167, 2009). Chemistry students'…

  8. Hiss emissions during quiet and disturbed periods

    Indian Academy of Sciences (India)

    D K Singh; R P Singh

    2002-10-01

    The characteristic features of VLF hiss emissions during quiet and disturbed conditions observed at ground stations and on-board satellites are summarized. The increased intensity of the hiss emissions during magnetic storm period is explained by considering the enhanced flux of energetic electrons during magnetic storm period. The generation and propagation mechanism of VLF hiss are also briefly discussed.

  9. Discontinuous Spirals of Stable Periodic Oscillations

    DEFF Research Database (Denmark)

    Sack, Achim; Freire, Joana G.; Lindberg, Erik;

    2013-01-01

    We report the experimental discovery of a remarkable organization of the set of self-generated periodic oscillations in the parameter space of a nonlinear electronic circuit. When control parameters are suitably tuned, the wave pattern complexity of the periodic oscillations is found to increase ...

  10. 24 CFR 221.775 - Option period.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Option period. 221.775 Section 221.775 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... § 221.775 Option period. The mortgagee may exercise its option to assign within one year following...

  11. 14 CFR 23.49 - Stalling period.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Stalling period. 23.49 Section 23.49... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Flight Performance § 23.49 Stalling period. (a) VSOand VS1are the stalling speeds or the minimum steady flight speeds, in knots (CAS),...

  12. BIVARIATE REAL-VALUED ORTHOGONAL PERIODIC WAVELETS

    Institute of Scientific and Technical Information of China (English)

    Qiang Li; Xuezhang Liang

    2005-01-01

    In this paper, we construct a kind of bivariate real-valued orthogonal periodic wavelets. The corresponding decomposition and reconstruction algorithms involve only 8 terms respectively which are very simple in practical computation. Moreover, the relation between periodic wavelets and Fourier series is also discussed.

  13. Nonlinear quasimodes near elliptic periodic geodesics

    CERN Document Server

    Albin, Pierre; Marzuola, Jeremy L; Thomann, Laurent

    2011-01-01

    We consider the nonlinear Schr\\"odinger equation on a compact manifold near an elliptic periodic geodesic. Using a geometric optics construction, we construct quasimodes to a nonlinear stationary problem which are highly localized near the periodic geodesic. We show the nonlinear Schr\\"odinger evolution of such a quasimode remains localized near the geodesic, at least for short times.

  14. Local field effects in periodic metamaterials

    Science.gov (United States)

    Porvatkina, O. V.; Tishchenko, A. A.; Strikhanov, M. N.

    2016-08-01

    In this article we investigate dielectric and magnetic properties of periodic metamaterials taking into account the so-called local field effect, caused by interaction between single particles the material consists of. We also consider the spatial dispersion effects. As a result, generalized Clausius-Mossotti techniques have been extended to the case of periodic metamaterials; permittivity tensor and permeability tensor were obtained.

  15. Automatically identifying periodic social events from Twitter

    NARCIS (Netherlands)

    Kunneman, F.A.; Bosch, A.P.J. van den

    2015-01-01

    Many events referred to on Twitter are of a periodic nature, characterized by roughly constant time intervals in between occurrences. Examples are annual music festivals, weekly television programs, and the full moon cycle. We propose a system that can automatically identify periodic events from Twi

  16. Studying the Nazi Period: Some Considerations.

    Science.gov (United States)

    Molnar, Alex; And Others

    1984-01-01

    Students should be taught how to make well-reasoned and analytic judgments about the Nazis. The process of arriving at judgments about the Nazi period should be characterized by a factual knowledge of the Nazi era within a general historical knowledge of the period, sympathy, and an open mind. (RM)

  17. 18 CFR 367.5 - Accounting period.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Accounting period. 367.5 Section 367.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Instructions § 367.5 Accounting period. Each service company must keep its books on a monthly basis so that...

  18. 46 CFR 403.115 - Accounting period.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Accounting period. 403.115 Section 403.115 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE UNIFORM ACCOUNTING SYSTEM General § 403.115 Accounting period. Each Association subject to this part shall...

  19. Periodicity of d-cluster-tilted algebras

    CERN Document Server

    Dugas, Alex

    2010-01-01

    It is well-known that any maximal Cohen-Macaulay module over a hypersurface has a periodic free resolution of period 2. Auslander, Reiten and Buchweitz have used this periodicity to explain the existence of periodic projective resolutions over certain finite-dimensional algebras which arise as stable endomorphism rings of Cohen-Macaulay modules. These algebras are in fact periodic, meaning that they have periodic projective resolutions as bimodules and thus periodic Hochschild cohomology as well. The goal of this article is to generalize this construction of periodic algebras to the context of Iyama's higher AR-theory. We start by considering projective resolutions of functors on a maximal (d-1)-orthogonal subcategory C of an exact Frobenius category B. If C is fixed by the d-th syzygy functor of B, then we show that this d-th syzygy functor induces the (2+d)-th syzygy on the category of finitely presented functors on the stable category of C. If C has finite type, i.e., if C = add(T) for a d-cluster tilting ...

  20. 42 CFR 441.58 - Periodicity schedule.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Periodicity schedule. 441.58 Section 441.58 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... schedule. The agency must implement a periodicity schedule for screening services that— (a)...

  1. Current Film Periodicals in English. Revised Edition.

    Science.gov (United States)

    Reilly, Adam, Comp.

    This bibliography of about 200 periodicals dealing with film covers several types of magazine: scholarly journals on film aesthetics, like "The Film Journal"; news notes for movie fans, like "Film Nut News"; magazines which cover films as well as the other arts, like "Cue" and "After Dark"; film education periodicals, like "Media and Methods";…

  2. Numerical bifurcation of Hamiltonian relative periodic orbits

    DEFF Research Database (Denmark)

    Wulff, Claudia; Schilder, Frank

    2009-01-01

    -breaking bifurcations of RPOs in Hamiltonian systems with compact symmetry group and show how they can be detected and computed numerically. These are turning points of RPOs and relative period-doubling and relative period-halving bifurcations along branches of RPOs. In a comoving frame the latter correspond...... to symmetry-breaking/symmetry-increasing pitchfork bifurcations or to period-doubling/period-halving bifurcations. We apply our methods to the family of rotating choreographies which bifurcate from the famous figure eight solution of the three-body problem as angular momentum is varied. We find...... that the family of choreographies rotating around the $e^2$-axis bifurcates to the family of rotating choreographies that connects to the Lagrange relative equilibrium. Moreover, we compute several relative period-doubling bifurcations and a turning point of the family of planar rotating choreographies, which...

  3. Bounded Correctors in Almost Periodic Homogenization

    Science.gov (United States)

    Armstrong, Scott; Gloria, Antoine; Kuusi, Tuomo

    2016-10-01

    We show that certain linear elliptic equations (and systems) in divergence form with almost periodic coefficients have bounded, almost periodic correctors. This is proved under a new condition we introduce which quantifies the almost periodic assumption and includes (but is not restricted to) the class of smooth, quasiperiodic coefficient fields which satisfy a Diophantine-type condition previously considered by Kozlov (Mat Sb (N.S), 107(149):199-217, 1978). The proof is based on a quantitative ergodic theorem for almost periodic functions combined with the new regularity theory recently introduced by Armstrong and Shen (Pure Appl Math, 2016) for equations with almost periodic coefficients. This yields control on spatial averages of the gradient of the corrector, which is converted into estimates on the size of the corrector itself via a multiscale Poincaré-type inequality.

  4. On Orbital Period Changes in Nova Outbursts

    CERN Document Server

    Martin, Rebecca G; Schaefer, Bradley E

    2011-01-01

    We propose a new mechanism that produces an orbital period change during a nova outburst. When the ejected material carries away the specific angular momentum of the white dwarf, the orbital period increases. A magnetic field on the surface of the secondary star forces a fraction of the ejected material to corotate with the star, and hence the binary system. The ejected material thus takes angular momentum from the binary orbit and the orbital period decreases. We show that for sufficiently strong magnetic fields on the surface of the secondary star, the total change to the orbital period could even be negative during a nova outburst, contrary to previous expectations. Accurate determinations of pre- and post-outburst orbital periods of recurrent nova systems could test the new mechanism, in addition to providing meaningful constraints on otherwise difficult to measure physical quantities. We apply our mechanism to outbursts of the recurrent nova U Sco.

  5. New Realization of Periodic Cycled Separation

    DEFF Research Database (Denmark)

    Toftegard, Bjarne; Clausen, Charlotte H.; Jørgensen, Sten B.;

    2016-01-01

    A new realization of periodic cycled gas/liquid separation is presented. Separation factors and column efficiencies are compared for a column stripping ammonia from water with air, using three different sets of internals: conventional sieve trays, Sulzer BX gauze packings, and periodically cycled...... trays. The proposed new periodic trays are shown to be advantageous compared to their continuous alternatives. It is demonstrated experimentally that periodic tray efficiencies of up to 300% are achievable. With the proposed new tray design, a new operation form is also introduced in which the trays...... are drained sequentially rather than simultaneously, such that the vapor flow is not interrupted during the liquid drainage. For different ratios of counter-current vapor/liquid flow rates, column efficiencies for periodically cycled columns are shown experimentally to be two times greater than those...

  6. Sensitivity analysis of periodic matrix population models.

    Science.gov (United States)

    Caswell, Hal; Shyu, Esther

    2012-12-01

    Periodic matrix models are frequently used to describe cyclic temporal variation (seasonal or interannual) and to account for the operation of multiple processes (e.g., demography and dispersal) within a single projection interval. In either case, the models take the form of periodic matrix products. The perturbation analysis of periodic models must trace the effects of parameter changes, at each phase of the cycle, on output variables that are calculated over the entire cycle. Here, we apply matrix calculus to obtain the sensitivity and elasticity of scalar-, vector-, or matrix-valued output variables. We apply the method to linear models for periodic environments (including seasonal harvest models), to vec-permutation models in which individuals are classified by multiple criteria, and to nonlinear models including both immediate and delayed density dependence. The results can be used to evaluate management strategies and to study selection gradients in periodic environments. PMID:23316494

  7. Period meter output during startup transients

    International Nuclear Information System (INIS)

    The time response of a period meter whose input signal comes from an ionization chamber may be calculated using a Ferranti Mercury digital computer programme. Details of the programme are given. The type of period meter considered is the one for which the input time constant is determined by the input capacity and the logarithmic element. The input excitation is a terminated ramp of reactivity. Other reactivity inputs may be treated. In particular the step change of reactivity may be used as the input excitation. Allowance is taken of the power dependent time constant associated with the logarithmic element and of the differentiating and integrating time constants in the period meter. The programme may be used by period meter designers to assess the performance of their instruments and may also be used by those carrying out safety and operations studies on reactors which use this type of period meter. An example of the use of the programme is given. (author)

  8. Periodicity of the earth's magnetic reversals

    Science.gov (United States)

    Stothers, R. B.

    1986-01-01

    Results are presented from an attempt to perform a relatively comprehensive analysis of the evidence for a periodicity, with harmonics, of the observed regular reversals of the earth's magnetic field. The database considered covers 296 reversals over the past 165 Myr. Histograms with bins 1 Myr apart reveal only 30 Myr reversal patterns. The reversal dates are fitted to a linear periodic function and a spectrum is computed for the residuals at the adopted dates. The possible presence of multiple periodicities is evaluated and over various time intervals. The analysis shows that a recently observed 15 Myr periodicity is probably a harmonic of the 29.5-30.5 Myr period. The calculations do not confirm an inherent magnetic reversal property of the earth. The reversals may arise from tectonic events or from impacts from extraterrestrial objects.

  9. Yougui Pill with the Treatment of Pulmonary Heart Disease Complicated with Chronic Obstructive Pulmonary Disease Re-mission Period of Curative Effect Observation Transfer Factor Capsules%右归丸配合转移因子胶囊治疗慢阻肺合并肺心病缓解期的疗效观察

    Institute of Scientific and Technical Information of China (English)

    赵兵; 周燕

    2015-01-01

    目的:观察右归丸配合转移因子胶囊治疗慢阻肺合并肺心病缓解期的临床疗效.方法:将92例慢性肺心病患者随机分为治疗组48例和对照组44例.治疗组在肺心病缓解期基础治疗 ,加用右归丸、转移因子胶囊口服 ,2周为1个疗程.休息3~5d ,进行下1个疗程 ,长期规律治疗.对照组给予慢性肺心病缓解期基础治疗.结果:治疗组症状评分较治疗前明显改善 ,治疗组总显效率为70 .8% ,对照组为45 .5% ,两组比较差异具有统计学意义( P<0 .05 ).治疗后治疗组平均急性发作次数为2 .4次/年 ,对照组为4.2次/年 ,两组比较结果有显著差异(P<0 .05).结论:右归丸配合转移因子胶囊治疗慢阻肺合并肺心病缓解期可显著减少急性发作次数.%Objective:To observe the Yougui Pill combined with Transfer Factor Capsules treatment of pulmonary heart disease complicated with chronic obstructive pulmonary disease clinical remission .Methods:92 patients with chro-nic pulmonary heart disease were randomly divided into treatment group 48 cases and control group with 44 cases .The treatment group remission therapy in pulmonary heart disease ,with Transfer Factor Capsules Yougui Pill ,oral ,2 weeks as a course of treatment .Rest 3~5 days ,proceed to the next course ,long-term regular treatment .The control group was treated with chronic cor pulmonale foundation treatment .Results:In treatment group ,the symptom score significantly improved compared with before treatment ,the total obvious effective rate of the treatment group was 70.8% ,the control group was 45 .5% efficiency .Results there were significant differences between the two groups (P<0 .05) .The treatment group the number of acute attack for an average of 2 .4 times per year ,controls the number of acute attack on average 4 .2 times per year .Results there were significant differences between the two groups (P<0.05) .Conclusion:Yougui Pill combined with

  10. Periodicity of extinction: A 1988 update

    Science.gov (United States)

    Sepkowski, J. John, Jr.

    1988-01-01

    The hypothesis that events of mass extinction recur periodically at approximately 26 my intervals is an empirical claim based on analysis of data from the fossil record. The hypothesis has become closely linked with catastrophism because several events in the periodic series are associated with evidence of extraterrestrial impacts, and terrestrial forcing mechanisms with long, periodic recurrences are not easily conceived. Astronomical mechanisms that have been hypothesized include undetected solar companions and solar oscillation about the galactic plane, which induce comet showers and result in impacts on Earth at regular intervals. Because these mechanisms are speculative, they have been the subject of considerable controversy, as has the hypothesis of periodicity of extinction. In response to criticisms and uncertainties, a data base was developed on times of extinction of marine animal genera. A time series is given and analyzed with 49 sample points for the per-genus extinction rate from the Late Permian to the Recent. An unexpected pattern in the data is the uniformity of magnitude of many of the periodic extinction events. Observations suggest that the sequence of extinction events might be the result of two sets of mechanisms: a periodic forcing that normally induces only moderate amounts of extinction, and independent incidents or catastrophes that, when coincident with the periodic forcing, amplify its signal and produce major-mass extinctions.

  11. Treatment of autoinflammatory diseases

    DEFF Research Database (Denmark)

    Ter Haar, Nienke; Lachmann, Helen; Özen, Seza;

    2013-01-01

    OBJECTIVE: To evaluate the response to treatment of autoinflammatory diseases from an international registry and an up-to-date literature review. METHODS: The response to treatment was studied in a web-based registry in which clinical information on anonymised patients with autoinflammatory...... diseases was collected retrospectively as part of the Eurofever initiative. Participating hospitals included paediatric rheumatology centres of the Paediatric Rheumatology International Trial Organisation network and adult centres with a specific interest in autoinflammatory diseases. The following...... diseases were included: familial Mediterranean fever (FMF), cryopyrin-associated periodic syndromes (CAPS), tumour necrosis factor (TNF)-receptor associated periodic syndrome (TRAPS), mevalonate kinase deficiency (MKD), pyogenic arthritis pustulosis acne (PAPA) syndrome, deficiency of interleukin-1...

  12. Fully automated period detection from variable stars' time series data

    CERN Document Server

    Shaju, K Y; Thayyullathil, Ramesh Babu

    2010-01-01

    We propose a fully automated method of period determination for the time series data of variable stars. For convenience the discussions in this paper are done in terms of frequency instead of period. Relying on the SigSpec technique (Reegen 2007), it employs a statistically unbiased treatment of frequency-domain noise and avoids spurious (i. e. noise induced) and alias peaks to the highest possible extent without any human intervention. From the output file produced by SigSpec, the frequency with maximum significance is chosen as the genuine frequency. We present tests on ASAS data and the results show that SigSpec can be effectively used for fully automated frequency detection from variable stars' time series data.

  13. Compensating for Quasi-periodic Motion in Robotic Radiosurgery

    CERN Document Server

    Ernst, Floris

    2012-01-01

    Compensating for Quasi-periodic Motion in Robotic Radiosurgery outlines the techniques needed to accurately track and compensate for respiratory and pulsatory motion during robotic radiosurgery. The algorithms presented within the book aid in the treatment of tumors that move during respiration. In Chapters 1 and 2,  the book introduces the concept of stereotactic body radiation therapy, motion compensation strategies and the clinical state-of-the-art. In Chapters 3 through 5, the author describes and evaluates new methods for motion prediction, for correlating external motion to internal organ motion, and for the evaluation of these algorithms’ output based on an unprecedented amount of real clinical data. Finally, Chapter 6 provides a brief introduction into currently investigated, open questions and further fields of research. Compensating for Quasi-periodic Motion in Robotic Radiosurgery targets researchers working in the related fields of surgical oncology, artificial intelligence, robotics and more. ...

  14. Alternative Treatments

    Science.gov (United States)

    ... Find your chapter: search by state Home > Alzheimer's Disease > Treatments > Alternative Treatments Overview What Is Dementia? What Is Alzheimer's? Younger/Early Onset Facts and Figures Know the 10 Signs Stages Inside the Brain: ...

  15. Stroke Treatments

    Science.gov (United States)

    ... T. Quiz 5 Things to Know About Stroke Stroke Treatments A stroke occurs when a vessel in ... Busting Clots to Save Lives Hemorrhagic Stroke Treatment Stroke Prevention The good news is that 80 percent ...

  16. The Jovian period in the Sun?

    Science.gov (United States)

    Kotov, V. A.

    2015-09-01

    The 41-year measurements of the Doppler effect of the photosphere performed at the Crimean Astrophysical Observatory, discovered two periods of global oscillations of the Sun: 9600.606(12) s and 9597.929(15) s. Their beat period, 398.4(2.9) d, well agrees with a synodic orbital period of Jupiter, PJ = 398.9 d, raising a new problem for solar physics, cosmogony and cosmology. A hypothesis is advanced that the PJ beating of the Sun is induced by gravitation of Jupiter, revolving in a privileged reference system "the Sun - the Earth".

  17. Optimal glucose management in the perioperative period.

    Science.gov (United States)

    Evans, Charity H; Lee, Jane; Ruhlman, Melissa K

    2015-04-01

    Hyperglycemia is a common finding in surgical patients during the perioperative period. Factors contributing to poor glycemic control include counterregulatory hormones, hepatic insulin resistance, decreased insulin-stimulated glucose uptake, use of dextrose-containing intravenous fluids, and enteral and parenteral nutrition. Hyperglycemia in the perioperative period is associated with increased morbidity, decreased survival, and increased resource utilization. Optimal glucose management in the perioperative period contributes to reduced morbidity and mortality. To readily identify hyperglycemia, blood glucose monitoring should be instituted for all hospitalized patients. PMID:25814110

  18. On the periods of generalized Fibonacci recurrences

    Science.gov (United States)

    Brent, Richard P.

    We give a simple condition for a linear recurrence (mod 2^w) of degree r to have the maximal possible period 2^(w-1).(2^r-1). It follows that the period is maximal in the cases of interest for pseudo-random number generation, i.e. for 3-term linear recurrences defined by trinomials which are primitive (mod 2) and of degree r > 2. We consider the enumeration of certain exceptional polynomials which do not give maximal period, and list all such polynomials of degree less than 15.

  19. Diffraction Theory and Almost Periodic Distributions

    Science.gov (United States)

    Strungaru, Nicolae; Terauds, Venta

    2016-09-01

    We introduce and study the notions of translation bounded tempered distributions, and autocorrelation for a tempered distribution. We further introduce the spaces of weakly, strongly and null weakly almost periodic tempered distributions and show that for weakly almost periodic tempered distributions the Eberlein decomposition holds. For translation bounded measures all these notions coincide with the classical ones. We show that tempered distributions with measure Fourier transform are weakly almost periodic and that for this class, the Eberlein decomposition is exactly the Fourier dual of the Lebesgue decomposition, with the Fourier-Bohr coefficients specifying the pure point part of the Fourier transform. We complete the project by looking at few interesting examples.

  20. Attractors of the periodically forced Rayleigh system

    Directory of Open Access Journals (Sweden)

    Petre Bazavan

    2011-07-01

    Full Text Available The autonomous second order nonlinear ordinary differential equation(ODE introduced in 1883 by Lord Rayleigh, is the equation whichappears to be the closest to the ODE of the harmonic oscillator withdumping.In this paper we present a numerical study of the periodic andchaotic attractors in the dynamical system associated with the generalized Rayleigh equation. Transition between periodic and quasiperiodic motion is also studied. Numerical results describe the system dynamics changes (in particular bifurcations, when the forcing frequency is varied and thus, periodic, quasiperiodic or chaotic behaviour regions are predicted.

  1. Clinical Efficacy Observation of the Treatment for Patients with Vulvovagi-nal Candidiasis during Pregnancy Period by Using Honghefujie Lotion%红核妇洁洗液治疗妊娠合并外阴阴道假丝酵母菌病的临床疗效探讨

    Institute of Scientific and Technical Information of China (English)

    蔡婷婷; 沈娟娟

    2015-01-01

    目的:探讨红核妇洁洗液治疗妊娠合并外阴阴道假丝酵母菌病的临床疗效和安全性评价,探讨临床价值。方法整群选择2011年6月—2014年6该院收治的妊娠合并外阴阴道假丝酵母菌病患者150例,随机分为研究组和对照组各75例,研究组应用红核妇洁洗液,对照组应用碘化钾及过氧化氢混合溶液进行治疗。疗程结束后对比两组的疗效。结果红核妇洁洗液组治疗总有效率达94.0%,对照组总有效率为66.0%,两组比较差异有统计学意义。结论妊娠合并外阴阴道假丝酵母菌病的治疗,应用红核妇洁洗液效果显著,治愈率高,使用安全、方便、疗程短,值得临床医师推广应用。%Objective To evaluate the efficacy and safety of Honghefujie lotion for the treatment of vulvovaginal candidiasis during pregnancy. Methods 150 cases of patients from 2011 June to 2014 June with vulvovaginal candidiasis in pregnancy, were divided into study group and control group with 75 cases in each group randomly, the research group used honghefujie lotion, treatment control group application of potassium iodide and hydrogen peroxide mixture solution. Compared the efficacy of the two groups be-fore and after treatment. Results The total effective rate of Honghefujie lotion treatment group reached 94%,and the control group’ s total effective rate was 66%, the difference between two groups was significant. Conclusion The combined treatment of vulvo-vaginal candidiasis in pregnancy,application of honghefujie lotion remarkable effect, high cure rate, safe and convenient use, short course of treatment, and is worthy of popularization and application of clinicians.

  2. Oral health: orthodontic treatment.

    Science.gov (United States)

    Martonffy, Andrea Ildiko

    2015-01-01

    Improper tooth alignment due to crowding, malocclusion, and missing teeth can cause difficulties with eating and speech, and premature wear. It is estimated that more than 20% of children would benefit from orthodontic treatment to correct these conditions, many of which will persist into adulthood if not corrected. Orthodontic care is gaining popularity among adults for similar concerns, as well as for correction of cosmetic issues. The psychological effects of malocclusion should not be ignored. The American Association of Orthodontists recommends that all children undergo evaluation at the first recognition of an orthodontic condition and no later than age 7 years. Some children will need early treatment to help eliminate developing conditions and improve the foundations of the bite, which can ease later treatment in adolescence. For others, treatment in adolescence without early treatment is recommended. Standard cemented braces or clear, removable aligners may be used, depending on the patient's corrective needs. Average treatment time is approximately 2 years; this may be shortened by the use of accelerative techniques. Routine preventive dental care should be continued during the treatment period. PMID:25594451

  3. Infinte Periodic Structure of Lightweight Elements

    DEFF Research Database (Denmark)

    Domadiya, Parthkumar Gandalal; Andersen, Lars Vabbersgaard; Sorokin, Sergey

    2013-01-01

    for proper dynamic assessment of lightweight buildings. Instead, this paper discusses and compares the use of finite element analysis and a wave approach based on Floquet theory. The present analysis has focus on the effect of periodicity on vibration transmission within semi-infinite beam structures. Two...... models of a semi-infinite Euler-Bernoulli and Timoshenko beam structure with periodic variation of the cross-sectional properties are analyzed. In case of the Euler-Bernoulli beam, vibrational behavior is studied in two dimensions by finite element analysis and Floquet theory. Wave propagation within...... the two-dimensional periodic Timoshenko beam structure is studied with a finite-element approach and compared with the periodic Euler-Bernoulli beam. The computations are carried out in frequency domain with the load acting as an impact load at the end of a semi-infinite beam. Results of various beam...

  4. A method to compute periodic sums

    CERN Document Server

    Gumerov, Nail A

    2013-01-01

    In a number of problems in computational physics, a finite sum of kernel functions centered at $N$ particle locations located in a box in three dimensions must be extended by imposing periodic boundary conditions on box boundaries. Even though the finite sum can be efficiently computed via fast summation algorithms, such as the fast multipole method (FMM), the periodized extension is usually treated via a different algorithm, Ewald summation, accelerated via the fast Fourier transform (FFT). A different approach to compute this periodized sum just using a blackbox finite fast summation algorithm is presented in this paper. The method splits the periodized sum in to two parts. The first, comprising the contribution of all points outside a large sphere enclosing the box, and some of its neighbors, is approximated inside the box by a collection of kernel functions ("sources") placed on the surface of the sphere or using an expansion in terms of spectrally convergent local basis functions. The second part, compri...

  5. UNVEILING THE PHENOMENON OF DOUBLE PERIODIC VARIABLES

    Directory of Open Access Journals (Sweden)

    R. E. Mennickent

    2009-01-01

    Full Text Available In this paper we give a brief report of our recent research on Double Periodic Variables (DPVs, including the discovery of DPVs in the Galaxy and some insights on the nature of their long-cycle variability.

  6. Subcortical cytoskeleton periodicity throughout the nervous system.

    Science.gov (United States)

    D'Este, Elisa; Kamin, Dirk; Velte, Caroline; Göttfert, Fabian; Simons, Mikael; Hell, Stefan W

    2016-03-07

    Superresolution fluorescence microscopy recently revealed a ~190 nm periodic cytoskeleton lattice consisting of actin, spectrin, and other proteins underneath the membrane of cultured hippocampal neurons. Whether the periodic cytoskeleton lattice is a structural feature of all neurons and how it is modified when axons are ensheathed by myelin forming glial cells is not known. Here, STED nanoscopy is used to demonstrate that this structure is a commonplace of virtually all neuron types in vitro. To check how the subcortical meshwork is modified during myelination, we studied sciatic nerve fibers from adult mice. Periodicity of both actin and spectrin was uncovered at the internodes, indicating no substantial differences between unmyelinated and myelinated axons. Remarkably, the actin/spectrin pattern was also detected in glial cells such as cultured oligodendrocyte precursor cells. Altogether our work shows that the periodic subcortical cytoskeletal meshwork is a fundamental characteristic of cells in the nervous system and is not a distinctive feature of neurons, as previously thought.

  7. Subcortical cytoskeleton periodicity throughout the nervous system.

    Science.gov (United States)

    D'Este, Elisa; Kamin, Dirk; Velte, Caroline; Göttfert, Fabian; Simons, Mikael; Hell, Stefan W

    2016-01-01

    Superresolution fluorescence microscopy recently revealed a ~190 nm periodic cytoskeleton lattice consisting of actin, spectrin, and other proteins underneath the membrane of cultured hippocampal neurons. Whether the periodic cytoskeleton lattice is a structural feature of all neurons and how it is modified when axons are ensheathed by myelin forming glial cells is not known. Here, STED nanoscopy is used to demonstrate that this structure is a commonplace of virtually all neuron types in vitro. To check how the subcortical meshwork is modified during myelination, we studied sciatic nerve fibers from adult mice. Periodicity of both actin and spectrin was uncovered at the internodes, indicating no substantial differences between unmyelinated and myelinated axons. Remarkably, the actin/spectrin pattern was also detected in glial cells such as cultured oligodendrocyte precursor cells. Altogether our work shows that the periodic subcortical cytoskeletal meshwork is a fundamental characteristic of cells in the nervous system and is not a distinctive feature of neurons, as previously thought. PMID:26947559

  8. The Detection of Hidden Periodicities in EEG

    Institute of Scientific and Technical Information of China (English)

    YOU Rong-yi

    2007-01-01

    Abstract.A novel method for detecting the hidden periodicities in EEG is proposed.By using a width-varying window in the time domain, the structure function of EEG time series is defined. It is found that the minima of the structure function, within a finite window width, can be found regularly, which indicate that there are some certain periodicities associated with EEG time series. Based on the structure function, a further quadratic structure function of EEG time series is defined. By quadratic structure function, it can be seen that the periodicities of EEG become more obvious, moreover, the period of EEG can be determined accurately. These results will be meaningful for studying the neuron activity inside the human brain.

  9. Unveiling the phenomenon of Double Periodic Variables

    CERN Document Server

    Mennickent, R E

    2009-01-01

    In this paper we give a brief report of our recent research on Double Periodic Variables (DPVs), including the discovery of DPVs in the Galaxy and some insights on the nature of their long-cycle variability.

  10. Global bioevents and the question of periodicity

    Science.gov (United States)

    Sepkoski, J. John

    The hypothesis of periodicity in extinction is an empirical claim that extinction events, while variable in magnitude, are regular in timing and therefore are serially dependent upon some single, ultimate cause with clocklike behavior. This hypothesis is controversal, in part because of questions regarding the identity and timing of certain extinction events and because of speculations concerning possible catastrophic extraterrestrial forcing mechanisms. New data on extinctions of marine animal genera are presented that display a high degree of periodicity in the Mesozoic and Cenozoic as well as a suggestion of nonstationary periodicity in the late Paleozoic. However, no periodicity is evident among the as yet poorly documented extinction events of the early and middle Paleozoic.

  11. Broiler adaptation to post-hatching period

    Directory of Open Access Journals (Sweden)

    Maiorka Alex

    2006-01-01

    Full Text Available In the latest years more attention has been given to mechanisms for bird adaptation at post-hatching period by management of environmental conditions and formulations of diets offered during this period when digestive, immune, and thermo-regulating systems suffer slight changes. In post-hatching period, digestive system is anatomically complete, but its functionality is still immature in relation to adult birds. The chick immunity depends on maternal antibodies transferred to egg just before laying. In addition, variations within thermal comfort zone might affect initial development of chick. For example, high temperatures may induce hyperthermia with dehydration, while low temperatures may lead to hypothermia responsible by pulmonary hypertension syndrome. In conclusion, productivity might be enhanced when good conditions are offered to chicks during the period from last embryo development to first days after hatching.

  12. Transversally periodic solitary gravity-capillary waves.

    Science.gov (United States)

    Milewski, Paul A; Wang, Zhan

    2014-01-01

    When both gravity and surface tension effects are present, surface solitary water waves are known to exist in both two- and three-dimensional infinitely deep fluids. We describe here solutions bridging these two cases: travelling waves which are localized in the propagation direction and periodic in the transverse direction. These transversally periodic gravity-capillary solitary waves are found to be of either elevation or depression type, tend to plane waves below a critical transverse period and tend to solitary lumps as the transverse period tends to infinity. The waves are found numerically in a Hamiltonian system for water waves simplified by a cubic truncation of the Dirichlet-to-Neumann operator. This approximation has been proved to be very accurate for both two- and three-dimensional computations of fully localized gravity-capillary solitary waves. The stability properties of these waves are then investigated via the time evolution of perturbed wave profiles. PMID:24399922

  13. A new pattern of the periodic table

    Directory of Open Access Journals (Sweden)

    Brajendra Nath Tripathi

    1962-07-01

    Full Text Available A new pattern of the Periodic Table is described which incorporates all the points for which various models of two or three dimensional tables have been proposed from time to time.

  14. Let Us Make the Table Periodic.

    Science.gov (United States)

    Campbell, J. Arthur

    1989-01-01

    An approach to teaching the properties of the elements and their arrangement in the periodic table is suggested. Discussed are symbols for the elements, format of the table, and coding the properties of the elements on the table. (CW)

  15. Ecological periodic tables: In principle and practice

    Science.gov (United States)

    The chemical periodic table, the Linnaean system of classification and the Hertzsprung-Russell diagram are iconic information organizing structure in chemistry, biology and astronomy, respectively, because they are simple, exceptionally useful and they foster the expansion of sci...

  16. Neutron transport with periodic boundary conditions

    Energy Technology Data Exchange (ETDEWEB)

    Angelescu, N.; Marinescu, N.; Protopopescu, V.

    1976-01-01

    The initial value problem for monoenergetic neutron transport in homogeneous nonmultiplying, nonabsorbing medium with isotropic scattering and periodic boundary conditions. One completely determines the structure of the spectrum of the transport operator both in plane and parallelepipedic geometries.

  17. Extracting periodic driving signal from chaotic noise

    Institute of Scientific and Technical Information of China (English)

    MU Jing; TAO Chao; DU Gonghuan

    2003-01-01

    After periodic signals pass through some nonlinear systems, they are usually transformed into noise-like and wide-band chaotic signals. The discrete spectrums of the original periodic signals are often covered by the chaotic spectrums. Recovering the periodic driving signals from the chaotic signals is important not only in theory but also in practical applications. Based on the modeling theory of nonlinear dynamic system, a "polynomial-simple harmonic drive" non-autonomous equation (P-S equation) to approximate the original system is proposed and the approximation error between P-S equation and the original system is obtained. By changing the drive frequency, we obtain the curve of the approximation error vs. drive frequency. Based on the relation between this curve and the spectrums of the original periodic signals, the spectrum of the original driving signal is extracted and the original signal is recovered.

  18. Stability of Periodic Locomotion in Potential Flow

    CERN Document Server

    Jing, Fangxu

    2013-01-01

    Most aquatic vertebrates swim by lateral flapping of their bodies and caudal fins. While much effort has been devoted to understanding the flapping kinematics and its influence on the swimming efficiency, little is known about the stability (or lack of) of periodic swimming. In this paper, we examine the stability of periodic locomotion due to sideways flapping in unbounded potential flow. It is believed that stability limits maneuverability and body designs/flapping motions that are adapted for stable swimming are not suitable for high maneuverability and vice versa. Here, we consider a simplified model where the swimmer is a planar elliptic body undergoing prescribed periodic heaving and pitching. We show that periodic locomotion can be achieved due to the resulting hydrodynamic forces, and its value depends on several parameters including the aspect ratio of the body, the amplitudes and phases of the prescribed flapping. We obtain closed-form solutions for the locomotion and efficiency for small flapping a...

  19. Periodic words connected with the Fibonacci words

    Directory of Open Access Journals (Sweden)

    G. M. Barabash

    2016-06-01

    Full Text Available In this paper we introduce two families of periodic words (FLP-words of type 1 and FLP-words of type 2 that are connected with the Fibonacci words and investigated their properties.

  20. Coping with Common Period Problems (For Teens)

    Science.gov (United States)

    ... and your period — is excessive exercising , usually distance running, ballet, or gymnastics, combined with a poor diet. For exercise to be excessive, it means more than just playing soccer a few times a week or working out ...

  1. DOREMI - Interim Progress Report (Period 2)

    OpenAIRE

    Rial, Michela; Benvenuti, Chiara; Vozzi, Federico; Parodi, Oberdan; Fortunati, Luigi; Palumbo, Filippo

    2015-01-01

    The DOREMI Scientific and Technological objectives of this period is: 1.2 . Development of preliminary version for the WSN environment, smart environment for context awareness and gamified environment (MS4, M18)

  2. [Homeostasis changes during rehabilitation period after acute chemical poisoning].

    Science.gov (United States)

    Badalian, A V; Luzhnikov, E A; Gol'dfarb, Iu S; Godkov, M A; Khvatov, V B; Bitkova, E E; El'kov, A N; Il'iashenko, K K; Nikulina, V P; Matveev, S B

    2013-01-01

    The article deals with review of 78 patients of rehabilitation toxicological unit. The patients received resuscitation and detoxification. All patients were divided into three groups; 1st group--patients after poisoning with psychopharmaceuticals, 2nd group--patients after poisoning with cauterizing liquids and 3rd group--patients with encephalopathy after poisoning with neurotoxin (psychopharmaceuticals, narcotics and ethanol). Disorders of rheology, haemostasis and endotoxicosis accrued in all groups. These disorders were a signs of the erythrocytes and platelets aggregation developing and viscoelasticity disorder. Homeostasis changes during rehabilitation period need an accurate diagnostics for purposeful treatment of the defined disorders.

  3. Periodic boundary conditions for dislocation dynamics simulations in three dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Bulatov, V V; Rhee, M; Cai, W

    2000-11-20

    This article presents an implementation of periodic boundary conditions (PBC) for Dislocation Dynamics (DD) simulations in three dimensions (3D). We discuss fundamental aspects of PBC development, including preservation of translational invariance and line connectivity, the choice of initial configurations compatible with PBC and a consistent treatment of image stress. On the practical side, our approach reduces to manageable proportions the computational burden of updating the long-range elastic interactions among dislocation segments. The timing data confirms feasibility and practicality of PBC for large-scale DD simulations in 3D.

  4. Positive periodic solutions of periodic neutral Lotka-Volterra system with state dependent delays

    Science.gov (United States)

    Li, Yongkun

    2007-06-01

    By using a fixed point theorem of strict-set-contraction, some new criteria are established for the existence of positive periodic solutions of the following periodic neutral Lotka-Volterra system with state dependent delays where (i,j=1,2,...,n) are [omega]-periodic functions and (i=1,2,...,n) are [omega]-periodic functions with respect to their first arguments, respectively.

  5. Periodicity and Immortality in Reversible Computing

    OpenAIRE

    Kari, Jarkko; Ollinger, Nicolas

    2008-01-01

    Additional material available on the web at http://www.lif.univ-mrs.fr/~nollinge/rec/gnirut/ We investigate the decidability of the periodicity and the immortality problems in three models of reversible computation: reversible counter machines, reversible Turing machines and reversible one-dimensional cellular automata. Immortality and periodicity are properties that describe the behavior of the model starting from arbitrary initial configurations: immortality is the property of having at ...

  6. IUPAC Periodic Table of the Isotopes

    Science.gov (United States)

    Holden, N.E.; Coplen, T.B.; Böhlke, J.K.; Wieser, M.E.; Singleton, G.; Walczyk, T.; Yoneda, S.; Mahaffy, P.G.; Tarbox, L.V.

    2011-01-01

    For almost 150 years, the Periodic Table of the Elements has served as a guide to the world of elements by highlighting similarities and differences in atomic structure and chemical properties. To introduce students, teachers, and society to the existence and importance of isotopes of the chemical elements, an IUPAC Periodic Table of the Isotopes (IPTI) has been prepared and can be found as a supplement to this issue.

  7. Perturbed period-doubling bifurcation. I. Theory

    DEFF Research Database (Denmark)

    Svensmark, Henrik; Samuelsen, Mogens Rugholm

    1990-01-01

    The influence of perturbations (a small, near-resonant signal and noise) on a driven dissipative dynamical system that is close to undergoing a period-doubling bifurcation is investigated. It is found that the system is very sensitive, and that periodic perturbations change its stability in a wel...... of a microwave-driven Josephson junction confirm the theory. Results should be of interest in parametric-amplification studies....

  8. Family of almost periodic Schroedinger operators

    International Nuclear Information System (INIS)

    Bellisard et al., introduced a one-dimensional, almost-periodic, discrete Schroedinger operator which is defined by a parameter lambda. We allow this parameter to become complex and develop a geometric formalism to control the operator. The support of the spectrum of this operator is the Julia set of the mapping x2 - lambda → x. We prove that the almost-periodicity holds over wide regions of the complex lambda-plane, even though Hermiticity fails. 14 references

  9. Discrete periodic geodesics in a surface

    OpenAIRE

    Linnér, Anders; Renka, Robert

    2005-01-01

    An alternative to the traditional curve-straightening flow on periodic curves in surfaces is introduced. The implementation of this flow produces periodic geodesics in minutes rather than hours. The flow is also simpler to initiate since its use of a penalty method permits initial curves that are not necessarily in the surface. Compact and noncompact examples are provided as well as examples with trivial and nontrivial free homotopy classes. The explicit curve-straightening flow on circles in...

  10. Periodic Exponential Shear of Complex Fluids

    OpenAIRE

    Kalelkar, Chirag; McKinley, Gareth

    2012-01-01

    We define a class of flows with exponential kinematics termed Periodic Exponential Shear (PES) flow which involve periodic exponential stretching of fluid elements along with their rotation. We exhibit analytical and numerical results for PES flow by using the Oldroyd-B model for viscoelastic fluids. We calculate the growth in the shear and the normal stresses analytically as well as demonstrate that repeated application of the flow leads to stable oscillatory shear and normal stresses. We de...

  11. How periodic orbit bifurcations drive multiphoton ionization

    OpenAIRE

    Huang, S.; Chandre, C; Uzer, T.

    2006-01-01

    The multiphoton ionization of hydrogen by a strong bichromatic microwave field is a complex process prototypical for atomic control research. Periodic orbit analysis captures this complexity: Through the stability of periodic orbits we can match qualitatively the variation of experimental ionization rates with a control parameter, the relative phase between the two modes of the field. Moreover, an empirical formula reproduces quantum simulations to a high degree of accuracy. This quantitative...

  12. Ground states for nonuniform periodic Ising chains

    OpenAIRE

    Martínez-Garcilazo, J. P.; Ramírez, C.

    2014-01-01

    We give a generalization of Morita's works on ground states of Ising chains, for chains with a periodic structure with different spins, and distant neighbor interactions. The main assumption is translational invariance. The length of the irreducible blocks is a multiple of the period of the chain. In the case of parity invariance, it restricts the length in general only in the diatomic case. There are degenerated states and under certain circumstances there could be nonregular ground states. ...

  13. Energy minimization, periodic sets and spherical designs

    CERN Document Server

    Coulangeon, Renaud

    2010-01-01

    We study energy minimization for pair potentials among periodic sets in Euclidean spaces. We derive some sufficient conditions under which a point lattice locally minimizes the energy associated to a large class of potential functions. This allows in particular to prove a local version of Cohn and Kumar's conjecture that $\\mathsf{A}_2$, $\\mathsf{D}_4$, $\\mathsf{E}_8$ and the Leech lattice are globally universally optimal, regarding energy minimization, and among periodic sets of fixed point density.

  14. Reducing or enhancing chaos using periodic orbits.

    Science.gov (United States)

    Bachelard, R; Chandre, C; Leoncini, X

    2006-06-01

    A method to reduce or enhance chaos in Hamiltonian flows with two degrees of freedom is discussed. This method is based on finding a suitable perturbation of the system such that the stability of a set of periodic orbits changes (local bifurcations). Depending on the values of the residues, reflecting their linear stability properties, a set of invariant tori is destroyed or created in the neighborhood of the chosen periodic orbits. An application on a paradigmatic system, a forced pendulum, illustrates the method.

  15. Electrons and photons in periodic structures

    DEFF Research Database (Denmark)

    Pedersen, Jesper Goor

    This thesis concerns various theoretical proposals for engineering dispersion relations of photons and electrons for particular applications. The common concept is the use of a periodic modulation to induce new phenomena on length scales comparable with the periodicity of the modulation. In parti......This thesis concerns various theoretical proposals for engineering dispersion relations of photons and electrons for particular applications. The common concept is the use of a periodic modulation to induce new phenomena on length scales comparable with the periodicity of the modulation...... periodic modulation of an electron gas leads to the emergence of localized defect states with energies within the band gap, where no propagating modes exist. Secondly, the divergence of the photonic density of states near a photonic band gap leads to strongly modified light-matter interactions, which has...... the way for graphene transistors. Photonic band gaps can be engineered using structures with a periodic modulations of the refractive index, commonly referred to as photonic crystal. We discuss the application of photonic crystals to slow light phenomena, where advantage is taken of the divergence...

  16. STEREO observations of long period variables

    CERN Document Server

    Wraight, K T; White, Glenn J; Nowotny, W; Norton, A J; Paladini, C

    2012-01-01

    Observations from the Heliospheric Imagers (HI-1) on both the STEREO spacecraft have been analysed to search for very long period large amplitude stellar variability, finding 6 new candidates. A total of 85 objects, mostly previously known Mira variables, were found to show convincing variability on time scales of over a hundred days. These objects range in peak brightness from about 4th magnitude to 10th magnitude in R and have periods between about 170 days and 490 days. There is a period gap between 200 and 300 days where no objects were found and this is discussed. 15 of the Miras in the sample are previously recorded as having variable periods and the possibility for these and 2 other stars to have undergone a period change or to be irregular is discussed. In addition to the 6 stars in the sample not previously recorded as variable, another 7 are recorded as variable but with no classification. Our period determination is the first to be made for 19 of these 85 stars. The sample represents a set of very ...

  17. The Catalina Surveys Periodic Variable Star Catalog

    CERN Document Server

    Drake, A J; Djorgovski, S G; Catelan, M; Mahabal, A A; Torrealba, G; Garcia-Alvarez, D; Donalek, C; Prieto, J L; Williams, R; Larson, S; Christensen, E; Belokurov, V; Koposov, S E; Beshore, E; Boattini, A; Gibbs, A; Hill, R; Kowalski, R; Johnson, J; Shelly, F

    2014-01-01

    We present ~47,000 periodic variables found during the analysis of 5.4 million variable star candidates within a 20,000 square degree region covered by the Catalina Surveys Data Release-1 (CSDR1). Combining these variables with type-ab RR Lyrae from our previous work, we produce an on-line catalog containing periods, amplitudes, and classifications for ~61,000 periodic variables. By cross-matching these variables with those from prior surveys, we find that > 90% of the ~8,000 known periodic variables in the survey region are recovered. For these sources we find excellent agreement between our catalog and prior values of luminosity, period and amplitude, as well as classification. We investigate the rate of confusion between objects classified as contact binaries and type-c RR Lyrae (RRc's) based on periods, colours, amplitudes, metalicities, radial velocities and surface gravities. We find that no more than few percent of these variables in these classes are misidentified. By deriving distances for this clean...

  18. 15. 7-min periodicity in OJ287

    Energy Technology Data Exchange (ETDEWEB)

    Valtaoja, E.; Lehto, H.; Teerikorpi, P.; Korhonen, T.; Valtonen, M.; Teraesranta, H.; Salonen, E.; Urpo, S.; Tiuri, M.; Piirola, V.; Saslaw, W.C.

    1985-03-14

    The BL Lac-type object OJ287, with a redshift z = 0.306 and a luminosity exceeding 10/sup 47/ erg s/sup -1/ at maximum light, is among the brightest and most violently variable objects of its class. Rapid variations, with timescales of a few hours or less, have been reported over a wide range of wavelengths and also in polarization, imposing strong constraints on the size and dynamics of the source. The detection of periodic variations in OJ287, or in any other compact extragalactic source, would be even more important, as these could be related to rotation or orbital motion in the source. So far the only searches sensitive to periodic variations shorter than 1 h are the photometric observations of Visvanathan and Elliot, Frohlich et al. and Kiplinger, in which a 40-min period in OJ287 was respectively found, confirmed and not detected. Here the detection of a 15.7-min periodic flux variation in OJ287 in April 1981 at 37 GHz is reported. The source has been subsequently monitored for 265 h at 22 and 37 GHz, as well as in optical photometry, and the same period has been seen in simultaneous observations. The peak-peak amplitude of the variation is 1-10% of the total intensity. Other periods may also exist. 17 references, 3 figures.

  19. The periodicity of the eta Carinae events

    CERN Document Server

    Damineli, A; Hillier, D J; Stahl, O; Levenhagen, R S; Leister, N V; Groh, J H; Teodoro, M; Colombo, J F Albacete; Gonzalez, F; Arias, J; Levato, H; Grosso, M; Morrell, N; Gamen, R; Wallerstein, G; Niemela, V

    2007-01-01

    Extensive spectral observations of eta Carinae over the last cycle, and particularly around the 2003.5 low excitation event, have been obtained. The variability of both narrow and broad lines, when combined with data taken from two earlier cycles, reveal a common and well defined period. We have combined the cycle lengths derived from the many lines in the optical spectrum with those from broad-band X-rays, optical and near-infrared observations, and obtained a period length of 2022.7+-1.3 d. Spectroscopic data collected during the last 60 years yield an average period of 2020+-4 d, consistent with the present day period. The period cannot have changed by more than $\\Delta$P/P=0.0007 since 1948. This confirms the previous claims of a true, stable periodicity, and gives strong support to the binary scenario. We have used the disappearance of the narrow component of HeI 6678 to define the epoch of the Cycle 11 minimum, T_0=JD 2,452,819.8. The next event is predicted to occur on 2009 January 11 (+-2 days). The d...

  20. Periodic Table Target: A Game that Introduces the Biological Significance of Chemical Element Periodicity

    Science.gov (United States)

    Sevcik, Richard S.; McGinty, Ragan L.; Schultz, Linda D.; Alexander, Susan V.

    2008-01-01

    Periodic Table Target, a game for middle school or high school students, familiarizes students with the form of the periodic table and the biological significance of different elements. The Periodic Table Target game board is constructed as a class project, and the game is played to reinforce the content. Students are assigned several elements…

  1. Treatment Effects

    DEFF Research Database (Denmark)

    Heckman, James J.; Lopes, Hedibert F.; Piatek, Rémi

    2014-01-01

    This paper contributes to the emerging Bayesian literature on treatment effects. It derives treatment parameters in the framework of a potential outcomes model with a treatment choice equation, where the correlation between the unobservable components of the model is driven by a low-dimensional v......This paper contributes to the emerging Bayesian literature on treatment effects. It derives treatment parameters in the framework of a potential outcomes model with a treatment choice equation, where the correlation between the unobservable components of the model is driven by a low...... observe the same person in both the treated and untreated states, but it also turns out to be straightforward to implement. Formulae are provided to compute mean treatment effects as well as their distributional versions. A Monte Carlo simulation study is carried out to illustrate how the methodology can...

  2. Adding 5-hydroxytryptamine receptor type 3 antagonists may reduce drug-induced nausea in poor insight obsessive-compulsive patients taking off-label doses of selective serotonin reuptake inhibitors: a 52-week follow-up case report

    OpenAIRE

    Martino Matteo; Fornaro Michele

    2010-01-01

    Abstract Poor-insight obsessive-compulsive disorder (PI-OCD) is a severe form of OCD where the 'typically obsessive' features of intrusive, 'egodystonic' feelings and thoughts are absent. PI-OCD is difficult to treat, often requiring very high doses of serotonergic drugs as well as antipsychotic augmentation. When this occurs, unpleasant side effects as nausea are common, eventually further reducing compliance to medication and increasing the need for pharmacological alternatives. We present ...

  3. The Discrete Beverton-Holt Model with Periodic Harvesting in a Periodically Fluctuating Environment

    Directory of Open Access Journals (Sweden)

    Ziyad AlSharawi

    2010-01-01

    Full Text Available We investigate the effect of constant and periodic harvesting on the Beverton-Holt model in a periodically fluctuating environment. We show that in a periodically fluctuating environment, periodic harvesting gives a better maximum sustainable yield compared to constant harvesting. However, if one can also fix the environment, then constant harvesting in a constant environment can be a better option, especially for sufficiently large initial populations. Also, we investigate the combinatorial structure of the periodic sequence of carrying capacities and its effect on the maximum sustainable yield. Finally, we leave some questions worth further investigations.

  4. Comparison of Single Periodical Control With Multiple-Periodical Sporadic Control Using Wavelet Feedback

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    It should be pointed out that there are two ways of applying nonlinear control using the wavelet-based feedback control: the single periodical (ΔP =1) control and multiple-periodical sporadic (interval)(ΔP≥2) control for controlling beam halo-chaos.Table 1 shows a comparison of results obtained before and after wavelet-based feedback controller at the 1 800th period. It is seen from table 1 that multiple-periodical sporadic (interval) control can also reach the same good results as the single periodical control, but it has much higher economic impact on practical application.

  5. Comparison of Characteristics of Periodic and Non-Periodic Defected Ground Structures

    Institute of Scientific and Technical Information of China (English)

    LI Yuan; LI Huancai; DING Ronglin

    2006-01-01

    The filter characteristic of defected ground structure(DGS)is analyzed and the equivalent circuit of C-shaped DGS is extracted. The characteristics of non-periodic and periodic DGS with different dimensions are compared. Then the DGS is simulated and optimized with software, and the circuit board is manufactured and measured. The non-periodic structure is simple in structure and small in size and ripple compared with the periodic structure. Though the stop band of the non-periodic structure is narrow, it can meet the requirement of application. The C-shaped structure with two stop bands can select frequency in a special band.

  6. THE CATALINA SURVEYS PERIODIC VARIABLE STAR CATALOG

    Energy Technology Data Exchange (ETDEWEB)

    Drake, A. J.; Graham, M. J.; Djorgovski, S. G.; Mahabal, A. A.; Donalek, C.; Williams, R. [California Institute of Technology, 1200 East California Boulevard, CA 91225 (United States); Catelan, M.; Torrealba, G. [Pontificia Universidad Católica de Chile, Instituto de Astrofísica, Facultad de Física, Av. Vicuña Mackena 4860, 782-0436 Macul, Santiago (Chile); García-Álvarez, D. [Instituto de Astrofísica de Canarias, Avenida Vía Láctea, E-38205 La Laguna, Tenerife (Spain); Prieto, J. L.; Beshore, E. [Department of Astronomy, Princeton University, 4 Ivy Ln., Princeton, NJ 08544 (United States); Larson, S.; Christen sen, E.; Boattini, A.; Gibbs, A.; Hill, R.; Kowalski, R.; Johnson, J. [Department of Planetary Sciences, Lunar and Planetary Laboratory, The University of Arizona, 1629 East University Boulevard, Tucson, AZ 85721 (United States); Belokurov, V.; Koposov, S. E. [Institute of Astronomy, Madingley Road, Cambridge CB3 0HA (United Kingdom); and others

    2014-07-01

    We present ∼47,000 periodic variables found during the analysis of 5.4 million variable star candidates within a 20,000 deg{sup 2} region covered by the Catalina Surveys Data Release-1 (CSDR1). Combining these variables with type ab RR Lyrae from our previous work, we produce an online catalog containing periods, amplitudes, and classifications for ∼61,000 periodic variables. By cross-matching these variables with those from prior surveys, we find that >90% of the ∼8000 known periodic variables in the survey region are recovered. For these sources, we find excellent agreement between our catalog and prior values of luminosity, period, and amplitude as well as classification. We investigate the rate of confusion between objects classified as contact binaries and type c RR Lyrae (RRc's) based on periods, colors, amplitudes, metallicities, radial velocities, and surface gravities. We find that no more than a few percent of the variables in these classes are misidentified. By deriving distances for this clean sample of ∼5500 RRc's, we trace the path of the Sagittarius tidal streams within the Galactic halo. Selecting 146 outer-halo RRc's with SDSS radial velocities, we confirm the presence of a coherent halo structure that is inconsistent with current N-body simulations of the Sagittarius tidal stream. We also find numerous long-period variables that are very likely associated within the Sagittarius tidal stream system. Based on the examination of 31,000 contact binary light curves we find evidence for two subgroups exhibiting irregular light curves. One subgroup presents significant variations in mean brightness that are likely due to chromospheric activity. The other subgroup shows stable modulations over more than a thousand days and thereby provides evidence that the O'Connell effect is not due to stellar spots.

  7. Auditory sustained field responses to periodic noise

    Directory of Open Access Journals (Sweden)

    Keceli Sumru

    2012-01-01

    Full Text Available Abstract Background Auditory sustained responses have been recently suggested to reflect neural processing of speech sounds in the auditory cortex. As periodic fluctuations below the pitch range are important for speech perception, it is necessary to investigate how low frequency periodic sounds are processed in the human auditory cortex. Auditory sustained responses have been shown to be sensitive to temporal regularity but the relationship between the amplitudes of auditory evoked sustained responses and the repetitive rates of auditory inputs remains elusive. As the temporal and spectral features of sounds enhance different components of sustained responses, previous studies with click trains and vowel stimuli presented diverging results. In order to investigate the effect of repetition rate on cortical responses, we analyzed the auditory sustained fields evoked by periodic and aperiodic noises using magnetoencephalography. Results Sustained fields were elicited by white noise and repeating frozen noise stimuli with repetition rates of 5-, 10-, 50-, 200- and 500 Hz. The sustained field amplitudes were significantly larger for all the periodic stimuli than for white noise. Although the sustained field amplitudes showed a rising and falling pattern within the repetition rate range, the response amplitudes to 5 Hz repetition rate were significantly larger than to 500 Hz. Conclusions The enhanced sustained field responses to periodic noises show that cortical sensitivity to periodic sounds is maintained for a wide range of repetition rates. Persistence of periodicity sensitivity below the pitch range suggests that in addition to processing the fundamental frequency of voice, sustained field generators can also resolve low frequency temporal modulations in speech envelope.

  8. Color Changes of Package Silage In Period of Aerobic Stability

    Directory of Open Access Journals (Sweden)

    F. Toruk

    2010-01-01

    Full Text Available In this study, changes on color of the silage surface, chemical and microbiological parameters in six days period of aerobic stability of package silage were investigated. For this purpose, the effect of the silage additive materials and treatments dose also were examined. Treatments were determined as Control (C, Silo-king firm dose (FD, Silo-King double dose (D2, Sim-Silage firm dose (SF, and Sim-Silage double dose (S2.Maize was ensiled using a package silage machine. The package silages opened after three months storage was analyzed for colors during aerobic exposure. In this research, yellowness (yı* indicates were also measured to show the effect of fermentation process on the silage color properties. As the result of experiment, it was found that aerobic stability have significant effects on color of the silage surface (all parameters statistically (p<0.05. The lowest color alteration (ΔE was estimated as 8.96 in S2 treatment. The color alteration also was increased 96 h when increased at pH and temperature. The highest CO2 values were found at firm dose treatments.

  9. Dipole interactions in doubly-periodic domains

    CERN Document Server

    Tsang, Alan Cheng Hou

    2013-01-01

    We consider the interactions of finite dipoles in a doubly-periodic domain. A finite dipole is a pair of equal and opposite strength point vortices separated by a finite distance. The dynamics of multiple finite dipoles in an unbounded inviscid uid was first proposed by Tchieu, Kanso & Newton in [1] as a model that captures the "far- field" hydrodynamic interactions in fish schools. In this paper, we formulate the equations of motion governing the dynamics of finite-dipoles in a doubly-periodic domain. We show that a single dipole in a doubly-periodic domain exhibits periodic and aperiodic behavior, in contrast to a single dipole in an unbounded domain. In the case of two dipoles in doubly-periodic domain, we identify a number of interesting trajectories including collision, collision avoidance, and passive synchronization of the dipoles. We then examine two types of dipole lattices: rectangular and diamond. We verify that these lattices are in a state of relative equilibrium and show that the rectangular...

  10. Visible periodicity of strong nucleosome DNA sequences.

    Science.gov (United States)

    Salih, Bilal; Tripathi, Vijay; Trifonov, Edward N

    2015-01-01

    Fifteen years ago, Lowary and Widom assembled nucleosomes on synthetic random sequence DNA molecules, selected the strongest nucleosomes and discovered that the TA dinucleotides in these strong nucleosome sequences often appear at 10-11 bases from one another or at distances which are multiples of this period. We repeated this experiment computationally, on large ensembles of natural genomic sequences, by selecting the strongest nucleosomes--i.e. those with such distances between like-named dinucleotides, multiples of 10.4 bases, the structural and sequence period of nucleosome DNA. The analysis confirmed the periodicity of TA dinucleotides in the strong nucleosomes, and revealed as well other periodic sequence elements, notably classical AA and TT dinucleotides. The matrices of DNA bendability and their simple linear forms--nucleosome positioning motifs--are calculated from the strong nucleosome DNA sequences. The motifs are in full accord with nucleosome positioning sequences derived earlier, thus confirming that the new technique, indeed, detects strong nucleosomes. Species- and isochore-specific variations of the matrices and of the positioning motifs are demonstrated. The strong nucleosome DNA sequences manifest the highest hitherto nucleosome positioning sequence signals, showing the dinucleotide periodicities in directly observable rather than in hidden form.

  11. The Last Element of Mendeleev's Periodic Table

    Science.gov (United States)

    Khazan, Albert

    2010-02-01

    Despite much achievements of the synthesis for super-heavy elements (10 new elements were obtained during the last 25 years), the experts in Mendeleev's Periodic Table have not answered the most fundamental question: where the Table ends? The calculations produced on the basis of Quantum Mechanics (the physical conditions in micro-scales) do not not answer this question till now. In my study of chemical compounds, I focused onto the physical conditions observed in macro-scales (the subjects of the regular physics and chemistry). Thus, the Law of Hyperboles was discovered in the Periodic Table: given any chemical compound, the contents of any element in it (per 1 gram-atom), including the contents of unknown elements, whose atomic masses can be set up arbitrarily, is described by the equation of a equilateral hyperbola Y=K/X. The tops of all the arcs are distributed along a real axis crossing the line Y=1 in the point of abscissa 411.66, which manifests the actual atomic mass of the last (heaviest) element of the Periodic Table: its location is Period 8, Group 1; its atomic mass is 411.66, its number is 155 (Khazan A. Upper Limit in Mendeleev's Periodic Table --- Element No.155. Svenska fysikarkivet, 2009). )

  12. Dietary treatments of obesity.

    Science.gov (United States)

    Bennett, W

    1987-01-01

    Dietary treatment of obesity is based on one or another of two premises: that the obese eat too much or that they eat the wrong things. The first is a tautology lacking explanatory power. The second is a meaningful and promising hypothesis but has yet to be effectively applied. At present, virtually all outpatient treatments of obesity, including behavior modification, are based on the first premise and consist of strategies for reducing the subject's caloric intake. Most such interventions produce short-term weight loss. Regain after the end of treatment remains the usual outcome. A survey of studies published in the period 1977-1986 and reporting on dietary or behavioral treatment of obesity reveals that the maximum percentage of body weight lost is, on average, 8.5 percent--no different from the value, 8.9%, in similar studies from 1966-1976, as reviewed by Wing and Jeffery. The principal determinant of success in such programs appears to be the intake weight of the subjects: the higher the intake weight, the more successful the intervention will appear to be. The goals and research methods of studies on dietary treatments for obesity are overdue for ethical as well as scientific reevaluation. The same may be said for the numerous programs providing such treatment outside the context of research.

  13. Osteoporosis treatment

    DEFF Research Database (Denmark)

    Pazianas, Michael; Abrahamsen, Bo

    2016-01-01

    The findings of the Women's Health Initiative study in 2002 marginalized the use of hormone replacement therapy and established bisphosphonates as the first line of treatment for osteoporosis. Denosumab could be used in selected patients. Although bisphosphonates only maintain the structure of bone...... to their benefits/harm ratio. Treatment of osteoporosis is a long process, and many patients will require treatment with more than one type of drug over their lifetime....

  14. NOSOCOMIAL INFECTIONS IN PATIENTS WITH UROLITHIASIS IN THE POSTOPERATIVE PERIOD

    Directory of Open Access Journals (Sweden)

    F. S. Sadulloev

    2015-01-01

    Full Text Available Abstract:Objective: To determine the most frequent causative agents of nosocomial infection in patients with urolithiasis in the postoperative period.Material and Methods. The study is based on the results of comprehensive studies conducted in 122 patients with nosocomial urinary tract infection, detected in 823 patients with urolithiasis treated by various methods. A cohort of 823 patients is isolated from 2688 patients treated without at admission signs of infections in the urinary tract for the period 2011–2014. All patients were treated at the Urological department of Avicenna Tajik State Medical University in the Republican Clinical Center of Urology. Main results. By the method of randomly selected 823 medical records of patients with urolithiasis various operations we carried out with 122 patients revealed cases of nosocomial infections. The diagnosis of nosocomial infections on the basis of established symptomatic urinary tract infection, asymptomatic bacteriuria or the presence of wound infection, use during the hospital stay for treatment of antibiotics, antiseptics, physiotherapy and other therapies. The incidence of nosocomial infections was studied in dependence with the severity of the underlying disease, the volume of surgical, invasive, endoscopic and other urological procedures, the timing and frequency of tests, the proportion of individual clinical manifestations in the overall structure of urinary tract infections, sex and age of patients.Conclusions. The leading microflora causing nosocomial infection in patients with urolithiasis in all treatments are gram-negative microorganisms, including prevailing E.coli (24,0%.

  15. Planar glass devices for efficient periodic poling

    DEFF Research Database (Denmark)

    Fage-Pedersen, Jacob; Jacobsen, Rune Shim; Kristensen, Martin

    2005-01-01

    We demonstrate that frequency-converting devices of high quality can be realised with glass poling. The devices, made with silica-on-silicon technology, are poled with periodic, embedded electrodes, and used for second-harmonic generation. We obtain precise control of the quasi phase-matching wav......We demonstrate that frequency-converting devices of high quality can be realised with glass poling. The devices, made with silica-on-silicon technology, are poled with periodic, embedded electrodes, and used for second-harmonic generation. We obtain precise control of the quasi phase......-matching wavelength and bandwidth, and a normalised conversion efficiency of 1.4×10-3 %/W/cm2 which, to our knowledge, is the highest obtained so far with periodic glass poling....

  16. Policy Uncertainty, Investment and Commitment Periods

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    Today's investment decisions in key sectors such as energy, forestry or transport have significant impacts on the levels of greenhouse gas (GHG) emissions over the coming decades. Given the economic and environmental long-term implications of capital investment and retirement, a climate mitigation regime should aim to encourage capital investment in climate-friendly technologies. Many factors affect technology choice and the timing of investment, including investor expectations about future prices and policies. Recent international discussions have focused on the importance of providing more certainty about future climate policy stringency. The design of commitment periods can play a role in creating this environment. This paper assesses how the length of commitment periods influences policy uncertainty and investment decisions. In particular, the paper analyses the relationship between commitment period length and near term investment decisions in climate friendly technology.

  17. Krsko NPP Periodic Safety Review program

    International Nuclear Information System (INIS)

    The need for conducting a Periodic Safety Review for the Krsko NPP has been clearly recognized both by the NEK and the regulator (SNSA). The PSR would be highly desirable both in the light of current trends in safety oversight practices and because of many benefits it is capable to provide. On January 11, 2001 the SNSA issued a decision requesting the Krsko NPP to prepare a program and determine a schedule for the implementation of the program for 'Periodic Safety Review of NPP Krsko'. The program, which is required to be in accordance with the IAEA safety philosophy and with the EU practice, was submitted for the approval to the SNSA by the end of March 2001. The paper summarizes Krsko NPP Periodic Safety Review Program [1] including implemented SNSA and IAEA Expert Mission comments.(author)

  18. Intermittence and roughening of periodic elastic media

    International Nuclear Information System (INIS)

    We analyze intermittence and roughening of an elastic interface or domain wall pinned in a periodic potential, in the presence of random-bond disorder in 1+1 and 2+1 dimensions. Though the ensemble average behavior is smooth, the typical behavior of a large sample is intermittent, and does not self-average to a smooth behavior. Instead, large fluctuations occur in the mean location of the interface and the onset of interface roughening is via an extensive fluctuation which leads to a jump in the roughness of order λ, the period of the potential. Analytical arguments based on extreme statistics are given for the number of the minima of the periodicity visited by the interface and for the roughening crossover, which is confirmed by extensive exact ground state calculations

  19. Periodic and Chaotic Flapping of Insectile Wings

    CERN Document Server

    Huang, Yangyang

    2015-01-01

    Insects use flight muscles attached at the base of the wings to produce impressive wing flapping frequencies. The maximum power output of these flight muscles is insufficient to maintain such wing oscillations unless there is good elastic storage of energy in the insect flight system. Here, we explore the intrinsic self-oscillatory behavior of an insectile wing model, consisting of two rigid wings connected at their base by an elastic torsional spring. We study the wings behavior as a function of the total energy and spring stiffness. Three types of behavior are identified: end-over-end rotation, chaotic motion, and periodic flapping. Interestingly, the region of periodic flapping decreases as energy increases but is favored as stiffness increases. These findings are consistent with the fact that insect wings and flight muscles are stiff. They further imply that, by adjusting their muscle stiffness to the desired energy level, insects can maintain periodic flapping mechanically for a range of operating condit...

  20. Electromagnetic Radiation of Electrons in Periodic Structures

    CERN Document Server

    Potylitsyn, Alexander Petrovich

    2011-01-01

    Periodic magnetic structures (undulators) are widely used in accelerators to generate monochromatic undulator radiation (UR) in the range from far infrared to the hard X-ray region. Another periodic crystalline structure is used to produce quasimonochromatic polarized photon beams via the coherent bremsstrahlung mechanism (CBS). Due to such characteristics as monochromaticity, polarization and adjustability, these types of radiation is of large interest for applied and basic research of accelerator-emitted radiation. The book provides a detailed overview of the fundamental principles behind electromagnetic radiation emitted from accelerated charged particles (e.g. UR, CBS, radiation of fast electrons in Laser flash fields) as well as a unified description of relatively new radiation mechanisms which attracted great interest in recent years. This are the so-called polarization radiation excited by the Coulomb field of incident particles in periodic structures, parametric X-rays, resonant transition radiation a...

  1. The incubation periods of Dengue viruses.

    Directory of Open Access Journals (Sweden)

    Miranda Chan

    Full Text Available Dengue viruses are major contributors to illness and death globally. Here we analyze the extrinsic and intrinsic incubation periods (EIP and IIP, in the mosquito and human, respectively. We identified 146 EIP observations from 8 studies and 204 IIP observations from 35 studies. These data were fitted with censored Bayesian time-to-event models. The best-fitting temperature-dependent EIP model estimated that 95% of EIPs are between 5 and 33 days at 25°C, and 2 and 15 days at 30°C, with means of 15 and 6.5 days, respectively. The mean IIP estimate was 5.9 days, with 95% expected between days 3 and 10. Differences between serotypes were not identified for either incubation period. These incubation period models should be useful in clinical diagnosis, outbreak investigation, prevention and control efforts, and mathematical modeling of dengue virus transmission.

  2. Local electrostatic moments and periodic boundary conditions

    Energy Technology Data Exchange (ETDEWEB)

    Schultz, P.A. [Sandia National Laboratories, Albuquerque, New Mexico 87185 (United States)

    1999-07-01

    Electronic structure calculations frequently invoke the supercell approximation and solve for electrostatic potentials within periodic boundary conditions. For systems that are electronically charged, or contain dipole (or higher) moments, this artifice introduces spurious potentials due to interactions between the system and multipole moments of its periodic images in aperiodic directions. I describe a method to handle properly the multipole moments of the electron density in electronic structure calculations using supercells. The density is divided into two pieces. A model local density is constructed to match multipole moments of the full density. The potential from this piece is obtained treating this density as isolated. With the density of this local-moment countercharge removed from the full density, the remainder density no longer contains moments with long-range potentials, and its electrostatic potential can be evaluated accurately using periodic boundary conditions. {copyright} {ital 1999} {ital The American Physical Society}

  3. Periodicity in Delta-modulated feedback control

    Institute of Scientific and Technical Information of China (English)

    Xiaohua XIA; Guanrong CHEN; Rudong GAI; Alan S. I. ZINOBER

    2008-01-01

    The Delta-modulated feedback control of a linear system introduces nonlinearity into the system through switchings between two input values. It has been found that Delta-modulation gives rise to periodic orbits. The existence of periodic points of all orders of Sigma-Delta modulation with "leaky" integration is completely characterized by some interesting groups of polynomials with "sign" coefficients. The results are naturally generalized to Sigma-Delta modulations with multiple delays, Delta-modulations in the "downlink", unbalanced Delta-modulations and systems with two-level quantized feedback. Further extensions relate to the existence of periodic points arising from Delta-modulated feedback control of a stable linear system in an arbitrary direction, for which some necessary and sufficient conditions are given.

  4. Effective propagation in a perturbed periodic structure

    International Nuclear Information System (INIS)

    In a recent paper [D. Torrent, A. Hakansson, F. Cervera, and J. Sanchez-Dehesa, Phys. Rev. Lett. 96, 204302 (2006)] inspected the effective parameters of a cluster containing an ensemble of scatterers with a periodic or a weakly disordered arrangement. A small amount of disorder is shown to have a small influence on the characteristics of the acoustic wave propagation with respect to the periodic case. In this Brief Report, we inspect further the effect of a deviation in the scatterer distribution from the periodic distribution. The quasicrystalline approximation is shown to be an efficient tool to quantify this effect. An analytical formula for the effective wave number is obtained in one-dimensional acoustic medium and is compared with the Berryman result in the low-frequency limit. Direct numerical calculations show a good agreement with the analytical predictions

  5. Long-period cascaded fiber taper filters.

    Science.gov (United States)

    Martinez-Rios, A; Salceda-Delgado, G; Guerrero-Viramontes, J A

    2014-02-10

    Fiber filters based on periodic cascaded tapered fiber sections are demonstrated. The filters consist of up to seven tapered sections separated periodically by more than 3 mm from center to center, with nominal tapered sections of 1  mm×1  mm×1  mm longitudinal dimensions. The transmission spectrum consists of discrete notches, resembling those observed in long-period fiber gratings, which differs from the observed spectrum in Mach-Zender interferometers based on cascaded tapers. Its sensitivity to external perturbations, such as refractive index or mechanical stress, made the device potentially very useful as a sensor or tunable filter. PMID:24663276

  6. Quantum periods of Calabi-Yau fourfolds

    CERN Document Server

    Gerhardus, Andreas

    2016-01-01

    In this work we study the quantum periods together with their Picard-Fuchs differential equations of Calabi-Yau fourfolds. In contrast to Calabi-Yau threefolds, we argue that the large volume points of Calabi-Yau fourfolds generically are regular singular points of the Picard-Fuchs operators of non-maximally unipotent monodromy. We demonstrate this property in explicit examples of Calabi-Yau fourfolds with a single Kahler modulus. For these examples we construct integral quantum periods and study their global properties in the quantum Kahler moduli space with the help of numerical analytic continuation techniques. Furthermore, we determine their genus zero Gromov-Witten invariants, their Klemm-Pandharipande meeting invariants, and their genus one BPS invariants. In our computations we emphasize the features attributed to the non-maximally unipotent monodromy property. For instance, it implies the existence of integral quantum periods that at large volume are purely worldsheet instanton generated. To verify ou...

  7. Detecting series periodicity with horizontal visibility graphs

    CERN Document Server

    Núñez, Angel M; Valero, Eusebio; Gómez, Jose Patricio; Luque, Bartolo

    2011-01-01

    The horizontal visibility algorithm has been recently introduced as a mapping between time series and networks. The challenge lies in characterizing the structure of time series (and the processes that generated those series) using the powerful tools of graph theory. Recent works have shown that the visibility graphs inherit several degrees of correlations from their associated series, and therefore such graph theoretical characterization is in principle possible. However, both the mathematical grounding of this promising theory and its applications are on its infancy. Following this line, here we address the question of detecting hidden periodicity in series polluted with a certain amount of noise. We first put forward some generic properties of horizontal visibility graphs which allow us to define a (graph theoretical) noise reduction filter. Accordingly, we evaluate its performance for the task of calculating the period of noisy periodic signals, and compare our results with standard time domain (autocorre...

  8. Short-Term Periodicities in Solar Indices

    Science.gov (United States)

    Kane, R. P.

    2005-03-01

    The purpose of the present communication is to identify the short-term (few tens of months) periodicities of several solar indices (sunspot number, Caii area and K index, Lyman α, 2800 MHz radio emission, coronal green-line index, solar magnetic field). The procedure used was: from the 3-month running means (3m) the 37-month running means (37m) were subtracted, and the factor (3m - 37m) was examined for several parameters. For solar indices, considerable fluctuations were seen during the ± 4 years around sunspot maxima of cycles 18-23, and virtually no fluctuations were seen in the ± 2 years around sunspot minima. The spacings between successive peaks were irregular but common for various solar indices. Assuming that there are stationary periodicities, a spectral analysis was carried out which indicated periodicities of months: 5.1 5.7, 6.2 7.0, 7.6 7.9, 8.9 9.6, 10.4 12.0, 12.8 13.4, 14.5 17.5, 22 25, 28 (QBO), 31 36 (QBO), 41 47 (QTO). The periodicities of 1.3 year (15.6 months) and 1.7 years (20.4 months) often mentioned in the literature were seen neither often nor prominently. Other periodicities occurred more often and more prominently. For the open magnetic flux estimated by Wang, Lean, and Sheeley (2000) and Wang and Sheeley (2002), it was noticed that the variations were radically different at different solar latitudes. The open flux for 45∘ solar latitudes had variations anti-parallel to the sunspot cycle. The open fluxes, interplanetary magnetic field and cosmic rays, all showed periodicities similar to those of solar indices. Many peaks (but not all) matched, indicating that the open flux for < 45∘ solar latitudes was at least partially an adequate carrier of the solar characteristics to the interplanetary space and thence for galactic cosmic ray modulation.

  9. Periodic paralysis: An unusual presentation of drug-induced hyperkalemia

    Directory of Open Access Journals (Sweden)

    Poonam Agrawal

    2014-01-01

    Full Text Available Hyperkalemia is a life-threatening electrolyte abnormality. The most common cause of hyperkalemia includes renal disease and ingestion of medications. Drug-induced hyperkalemia may develop in patients with underlying renal impairment, disturbed cellular uptake of potassium load, excessive ingestion or infusion of potassium-containing substances. We report a case of "drug-induced severe hyperkalemia" presenting as periodic paralysis. A 67-year-old diabetic and hypertensive woman presented to emergency department with the complaint of intermittent episode of inability to walk for the past 5 days. Each episode lasted for 15-20 minutes and was associated with breathlessness and restlessness. There was no family history of periodic paralysis and drug history revealed that the patient was onolmesartan 20 mg per day (for past 2 years, perindopril 4 mg per day (for past 16 months, and torsemide 10 mg/day. On examination patient was found to be conscious, alert, and afebrile. Vitals were normal. Examination of cardiovascular and respiratory system did not reveal any significant finding. Blood report of the patient showed serum K+ level 8.6 mmol/l. All other investigations were within normal limits. A diagnosis of drug-induced hyperkalemia was made. Patient responded well to the symptomatic treatment. To the best of the author′s knowledge, this is the first case report of drug-induced hyperkalemia presenting as periodic paralysis.

  10. Electrostatics of solvated systems in periodic boundary conditions

    Science.gov (United States)

    Andreussi, Oliviero; Marzari, Nicola

    2014-12-01

    Continuum solvation methods can provide an accurate and inexpensive embedding of quantum simulations in liquid or complex dielectric environments. Notwithstanding a long history and manifold applications to isolated systems in open boundary conditions, their extension to materials simulations, typically entailing periodic boundary conditions, is very recent, and special care is needed to address correctly the electrostatic terms. We discuss here how periodic boundary corrections developed for systems in vacuum should be modified to take into account solvent effects, using as a general framework the self-consistent continuum solvation model developed within plane-wave density-functional theory [O. Andreussi et al., J. Chem. Phys. 136, 064102 (2012), 10.1063/1.3676407]. A comprehensive discussion of real- and reciprocal-space corrective approaches is presented, together with an assessment of their ability to remove electrostatic interactions between periodic replicas. Numerical results for zero- and two-dimensional charged systems highlight the effectiveness of the different suggestions, and underline the importance of a proper treatment of electrostatic interactions in first-principles studies of charged systems in solution.

  11. Periodic orbits near a bifurcating slow manifold

    DEFF Research Database (Denmark)

    Kristiansen, Kristian Uldall

    2015-01-01

    This paper studies a class of $1\\frac12$-degree-of-freedom Hamiltonian systems with a slowly varying phase that unfolds a Hamiltonian pitchfork bifurcation. The main result of the paper is that there exists an order of $\\ln^2\\epsilon^{-1}$-many periodic orbits that all stay within an $\\mathcal O......(\\epsilon^{1/3})$-distance from the union of the normally elliptic slow manifolds that occur as a result of the bifurcation. Here $\\epsilon\\ll 1$ measures the time scale separation. These periodic orbits are predominantly unstable. The proof is based on averaging of two blowup systems, allowing one to estimate...

  12. Kepler RR Lyrae stars: beyond period doubling

    CERN Document Server

    Molnár, L; Szabó, R; Kolláth, Z

    2013-01-01

    We examined the complete short cadence sample of Kepler RR Lyrae stars to further investigate the recently discovered dynamical effects such as period doubling and additional modes. Here we present the findings on four stars. V450 Lyr may be a non-classical double-mode RR Lyrae star pulsating in the fundamental mode and the second overtone. In three cases we observe the interaction of three different modes. Since the period ratios are close to resonant values, we observe quasi-repetiting patterns in the pulsation cycles in the stars. These findings support the mode-resonance explanations of the Blazhko effect.

  13. Reconstruction of periodic signals using neural networks

    Directory of Open Access Journals (Sweden)

    José Danilo Rairán Antolines

    2014-01-01

    Full Text Available In this paper, we reconstruct a periodic signal by using two neural networks. The first network is trained to approximate the period of a signal, and the second network estimates the corresponding coefficients of the signal's Fourier expansion. The reconstruction strategy consists in minimizing the mean-square error via backpro-pagation algorithms over a single neuron with a sine transfer function. Additionally, this paper presents mathematical proof about the quality of the approximation as well as a first modification of the algorithm, which requires less data to reach the same estimation; thus making the algorithm suitable for real-time implementations.

  14. Stochastic dynamics of a periodical reactor

    International Nuclear Information System (INIS)

    The dynamics of a pulsed periodical reactor (PPR) are analyzed beyond the region of stability on the basis of a discrete model is analyzed. It is shown that at a certain power lewel PPR with negative temperature coefficient will inevitably feature the stochastic behaviour of power pulse energy, the so called determinated chaos. The nature of transition to the chaos depends on the nature of feedback and specific model of dynamics. Feingenbaum transition in the most likely one when the random motion occurs after an infinite sequence of bifureations of oscillation period doubling. It also shown that PPR transition to chaos may be considered as a safe one. 16 refs.; 10 figs

  15. Periodicity in bimodal atomic force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Lai, Chia-Yun; Santos, Sergio, E-mail: santos-en@yahoo.com; Chiesa, Matteo [Laboratory for Energy and NanoScience (LENS), Institute Center for Future Energy (iFES), Masdar Institute of Science and Technology, Abu Dhabi (United Arab Emirates); Barcons, Victor [Departament de Disseny i Programació de Sistemes Electrònics, UPC - Universitat Politècnica de Catalunya, Av. Bases, 61, 08242 Manresa (Barcelona) (Spain)

    2015-07-28

    Periodicity is fundamental for quantification and the application of conservation principles of many important systems. Here, we discuss periodicity in the context of bimodal atomic force microscopy (AFM). The relationship between the excited frequencies is shown to affect and control both experimental observables and the main expressions quantified via these observables, i.e., virial and energy transfer expressions, which form the basis of the bimodal AFM theory. The presence of a fundamental frequency further simplifies the theory and leads to close form solutions. Predictions are verified via numerical integration of the equation of motion and experimentally on a mica surface.

  16. Periodic optimization of continuous microbial growth processes.

    Science.gov (United States)

    Abulesz, E M; Lyberatos, G

    1987-06-01

    Steady-state operation of continuous bioreactors is not necessarily the optimum type of operation. The method of pi-criterion is used in this work to determine whether periodic variation of the dilution rate can enhance the performance of continuous fermentation processes. It is found that the presence of time delay in the dynamic response of the chemostat renders a periodic operation of bioreactors, used for biomass production, superior to any steady-state operation. Also, employing Williams' structured model it is shown that cycling improves the average protein productivity. PMID:18576558

  17. Treatment of pemphigus vulgaris and pemphigus foliaceus: experience with 71 patients over a 20 year period Tratamento do pênfigo vulgar e pênfigo foliáceo: experiência com 71 pacientes no período de 20 anos

    Directory of Open Access Journals (Sweden)

    Nurimar C. FERNANDES

    2001-02-01

    Full Text Available Forty one cases of pemphigus vulgaris and thirty cases of pemphigus foliaceus were investigated at Hospital Universitário Clementino Fraga Filho from 1978 to 1999. They were divided into two treatment groups: one group received up to 100 mg of oral prednisone daily and the other group received >120 mg daily. The dose up to 100 mg provided good initial control of pemphigus vulgaris and pemphigus foliaceus and did not increase the mortality rate associated to disease. The dose >120 mg induced higher morbidity. These data allowed us to establish a regimen of oral prednisone (1-2 mg/kg/daily with maximum of 120 mg daily in the treatment of pemphigus vulgaris and pemphigus foliaceus.Quarenta e um casos de pênfigo vulgar e trinta casos de pênfigo foliáceo foram investigados no Hospital Universitário Clementino Fraga Filho, no período 1978-1999. Os pacientes foram divididos em dois grupos de tratamento: um recebendo até 100 mg/dia de prednisona e o outro grupo >120 mg diariamente. Com o primeiro esquema, houve bom controle inicial dos pênfigos sem aumento da taxa de mortalidade associada às doenças. A dose acima de 120 mg induziu maior morbidade. Os resultados permitiram estabelecer um esquema de prednisona (1-2 mg/kg/dia com dose máxima de 120 mg diários no tratamento dos pênfigos vulgar e foliáceo.

  18. Periodic leg movements in prepubertal children with sleep disturbance.

    Science.gov (United States)

    Martinez, Sandra; Guilleminault, Christian

    2004-11-01

    This study's aims were to determine: (1) prevalence of periodic leg movements (PLMs) in walking prepubertal children consulting a sleep clinic for any sleep disorder; (2) associations between PLMs and other sleep and medical disorders; and (3) the response of other sleep disorders to treatment with the dopamine agonist pramipexol. Clinical evaluation and polysomnography were carried out for a period of 12 months on 252 consecutively seen, prepubertal children with sleep disorders (156 males, 96 females; aged 15mo to 11y, mean 7y 1mo, SD3y 10mo). Sleep disorders unrelated to PLMs were treated, and six children received pramipexol for PLMs. Follow-up included clinical evaluation and polysomnography. Twenty-three per cent of children were diagnosed with PLMs on the basis of polysomnography. The presence of PLMs had usually been unrecognized clinically. The only clinical symptom that could be related to periodic limb movement disorder was a report of leg pains at morning awakening. Only two of 58 children had PLMs without other clinical or polysomnographic findings. Comorbidity seen with PLMs included neuropsychiatric syndromes (n=20), isolated sleep disordered breathing (SDB; n=29), and several other comorbid conditions (n=7). Seven of 11 children seen with attention-deficit-hyperactivity disorder also had PLMs. Surgery for SDB was associated with subsequent cessation of PLMs in 15 of 29 children. Five out of six children with PLMs who received pramipexol were able to tolerate the drug and experienced a complete disappearance of their PLMs. Presence of chronic fatigue, sleepiness, disrupted nocturnal sleep, and difficulties in falling asleep should lead to a systematic search for PLMs that is independent of associated syndromes. Isolated treatment of SDB might help eliminate some, but not all, PLMs. PMID:15540638

  19. A new method for calculating the average period of current assets turnover in the analyzed period

    OpenAIRE

    Kulakova Julija Nikolaevna; Kulakov Andrej Borisovich

    2015-01-01

    The aim of this study is to develop a new method for calculating the average period of current assets turnover during the analyzed period without using of financial results (revenue, cost, etc.). To prove the advantages of the proposed method in comparison with the traditional method of calculating turnover the example of estimating the mean residence time in the analyzed period of working capital in the form of receivables is developed.

  20. A new method for calculating the average period of current assets turnover in the analyzed period

    Directory of Open Access Journals (Sweden)

    Kulakova Julija Nikolaevna

    2015-05-01

    Full Text Available The aim of this study is to develop a new method for calculating the average period of current assets turnover during the analyzed period without using of financial results (revenue, cost, etc.. To prove the advantages of the proposed method in comparison with the traditional method of calculating turnover the example of estimating the mean residence time in the analyzed period of working capital in the form of receivables is developed.

  1. Comparative study of thyrotoxic periodic paralysis from idiopathic hypokalemic periodic paralysis: An experience from India

    OpenAIRE

    Kalita, J; G Goyal; Bhoi, S. K.; Chandra, S.; Misra, U K

    2012-01-01

    Objective: There is paucity of reports on thyrotoxic periodic paralysis (TPP) from India. We report the patients with TPP and compare them with idiopathic hypokalemic periodic paralysis (IHPP). Materials and Methods: Patients with hypokalemic periodic paralysis (HPP) treated during the past 11 years were evaluated retrospectively. Their demographic parameters, family history, clinical features, precipitating factors, severity of weakness, laboratory parameters and rapidity of recovery were re...

  2. Competing periodicities in a convecting system

    International Nuclear Information System (INIS)

    In this study, a variety of novel phases was discovered in a nonequilibrium system that has undergone an instability. These phases are closely related to commensurate and incommensurate states found in many solid state materials. It is widely recognized that this behavior is a general phenomenon resulting from the presence of two competing lengths. To study the effects of competing periodicities in a nonequilibrium system, a convective flow was subjected to spatially periodic forcing with a period different from the naturally chosen one. For reasons of experimental convenience, an electrohydrodynamic instability in a thin layer of nematic liquid crystal was utilized. Samples containing several hundred rolls are easily obtained and visualized; thus, phenomena occurring in an effectively infinite layer could be studied. The periodic forcing is imposed by using a specially designed interdigitated electrode. The author found, both commensurate and incommensurate states of several distinct types, and used digital image analysis to study their structure. In a separate investigation, the first direct observation was made of the Eckhaus instability, a phenomenon characterized by long wavelength modulations of a primary roll structure

  3. Periodic orbits in hyperchaotic Chen systems

    Directory of Open Access Journals (Sweden)

    Susanna Maza

    2015-08-01

    Full Text Available In this work, we show a zero-Hopf bifurcation in a Hyperchaotic Chen system. Using averaging theory, we prove the existence of two periodic orbits bifurcating from the zero-Hopf equilibria located at the origin of the Hyperchaotic Chen system.

  4. China's Economy Enters Key Period of Softlanding

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

      China's economy is now at a key period for softlanding in light of growing investment, the driving force of its fast economic expansion,according to a report by a task force for the State Development and Reform Commission(SDRC).……

  5. China's Economy Enters Key Period of Softlanding

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ China's economy is now at a key period for softlanding in light of growing investment, the driving force of its fast economic expansion,according to a report by a task force for the State Development and Reform Commission(SDRC).

  6. PHYSICAL EDUCATION AND SPORTS IN PRESCHOOL PERIOD

    OpenAIRE

    Arzu ÖZYÜREK; ÖZKAN, İsa; Zuhal BEGDE; N. Ferah YAVUZ

    2015-01-01

    Early childhood is known as a critical period for development and fundamental movement skills. Growing and development of children have an effect on gaining fundamental movement skills. Besides, the opportu nities and movement education provided for the students play an essential role on developing fundamental movement skills poisedly. In preschool education, physical training is the leading activity given the least i...

  7. Theory of Periodic Conjugate Heat Transfer

    CERN Document Server

    Zudin, Yuri B

    2012-01-01

    This book presents the theory of periodic conjugate heat transfer in a detailed way. The effects of thermophysical properties and geometry of a solid body on the commonly used and experimentally determined heat transfer coefficient are analytically presented from a general point of view. The main objective of the book is a simplified description of the interaction between a solid body and a fluid as a boundary value problem of the heat conduction equation for the solid body. At the body surface, the true heat transfer coefficient is composed of two parts: the true mean value resulting from the solution of the steady state heat transfer problem and a periodically variable part, the periodic time and length to describe the oscillatory hydrodynamic effects. The second edition is extended by (i) the analysis of stability boundaries in helium flow at supercritical conditions in a heated channel with respect to the interaction between a solid body and a fluid; (ii) a periodic model and a method of heat transfer sim...

  8. Periodically forced ferrofluid pendulum: effect of polydispersity

    CERN Document Server

    Leschhorn, A

    2006-01-01

    We investigate a torsional pendulum containing a ferrofluid that is forced periodically to undergo small-amplitude oscillations. A homogeneous magnetic field is applied perpendicular to the pendulum axis. We give an analytical formula for the ferrofluid-induced ``selfenergy'' in the pendulum's dynamic response function for monodisperse as well as for polydisperse ferrofluids.

  9. 49 CFR 232.611 - Periodic maintenance.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Periodic maintenance. 232.611 Section 232.611 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... maintenance. (a) In addition to the maintenance requirements contained in § 232.303(b) through (d), a...

  10. 75 FR 41989 - Content of Periodicals Mail

    Science.gov (United States)

    2010-07-20

    ... published a final rule in the Federal Register (60 FR 10021-10029) revising the standards. Since that time... design. The sentence ``Not all elements that make up a multilayer page must be printed'' is added to 3.3... (CSR) PS- 234, titled ``Multilayer pages in Periodicals Publications.'' Finally, the sentence...

  11. PERIODIC SOLUTIONS OF ASYMPTOTICALLY LINEAR HAMILTONIAN SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    FEIGUIHUA; QIUQINGJIU

    1997-01-01

    The authors establish the existence of nontrival periodic solutions of the asymptotically linear Hamiltomian systems in the general case that the asymptotic matrix may be degenerate and time-dependent.This is done by using the critical point theory,Galerkin approximation procedure and the Maslov-type index theory introduced and generalized by Conley,Zehnder and Long.

  12. Rotational Period Determination for (8563) 1995 US

    Science.gov (United States)

    Papini, Riccardo; Marchini, Alessandro; Marullo, Sara; Salvaggio, Fabio

    2016-01-01

    Analysis of photometric observations in 2015 August of the main-belt asteroid (8563) 1995 US found the most likely synodic period to be 3.197 ± 0.001 hours with a lightcurve amplitude of 0.56 ± 0.03 mag.

  13. Rotation Period Determination for 5401 Minamioda

    Science.gov (United States)

    Marchini, Alessandro; Franco, Lorenzo; Papini, Riccardo; Salvaggio, Fabio

    2016-04-01

    Photometric observations of the main-belt asteroid 5401 Minamioda in 2015 November revealed a monomodal lightcurve phased to 3.949 ± 0.001 hours as the more likely solution for the synodic rotation period of the asteroid, although a bimodal solution phased to 7.897 ± 0.003 hours cannot be ruled out completely.

  14. Rotation Period Determination for 671 Carnegia

    Science.gov (United States)

    Benishek, Vladimir; Papini, Riccardo

    2014-10-01

    Analysis of photometric observations of the main-belt asteroid 671 Carnegia from 2014 January-March revealed a bimodal lightcurve with a period of 8.332 ± 0.001 hours as the most likely solution. However, a trimodal solution of 12.50 hours still could not be formally ruled out.

  15. Ecological periodic tables for estuarine habitats

    Science.gov (United States)

    Southwood (1977; J Anim Ecol 46: 337-365) compared the situation in ecology to that in chemistry before the development of the periodic table when each fact, for example, the solubility or reactivity of a chemical element, had to be discovered independently and remembered in isol...

  16. Relating Functional Groups to the Periodic Table

    Science.gov (United States)

    Struyf, Jef

    2009-01-01

    An introduction to organic chemistry functional groups and their ionic variants is presented. Functional groups are ordered by the position of their specific (hetero) atom in the periodic table. Lewis structures are compared with their corresponding condensed formulas. (Contains 5 tables.)

  17. The Different Periodic Tables of Dmitrii Mendeleev

    Science.gov (United States)

    Laing, Michael

    2008-01-01

    Between 1869 and 1905 the Russian chemist Dmitrii Mendeleev published several tables with different arrangements of the chemical elements. Four of these are compared with periodic tables by Russian scientists from 1934 and 1969. The difficulties caused by the lanthanoid elements are clearly seen in the table of 1905, which satisfactorily includes…

  18. Amorites in the Early Old Babylonian Period

    NARCIS (Netherlands)

    Boer, Rients de

    2014-01-01

    The Amorites are known throughout the history of the Ancient Near East: they occur in texts from the Ur III empire (2100–2000 bc), but also in the Bible. In the Old Babylonian period (2000–1600 bc), several dynasties of Amorite kings ruled all over the Middle East. They came to power in the early Ol

  19. Quantum fields, periods and algebraic geometry

    OpenAIRE

    Kreimer, Dirk

    2014-01-01

    We discuss how basic notions of graph theory and associated graph polynomials define questions for algebraic geometry, with an emphasis given to an analysis of the structure of Feynman rules as determined by those graph polynomials as well as algebraic structures of graphs. In particular, we discuss the appearance of renormalization scheme independent periods in quantum field theory.

  20. Mental Illness in the Peripartum Period

    Science.gov (United States)

    Ostler, Teresa

    2009-01-01

    Women are particularly vulnerable in the peripartum period for either developing a mental illness or suffering symptom exacerbation. These illnesses are often experienced covertly, however, and women may not seek out professional help, even though their symptoms may be seriously affecting their well-being and parenting. This article provides an…

  1. PERIODIC-SOLUTIONS IN SPONTANEOUSLY BROKEN THEORIES

    NARCIS (Netherlands)

    BRIHAYE, Y; KUNZ, J

    1992-01-01

    A class of spontaneously broken field theories is proposed, and the occurrence of their periodic, classical solutions is investigated in detail. The emergence of multiple solutions is observed, their normal modes of oscillation are studied, and the bifurcations of the classical energy functional are

  2. The electrostatic potential of a periodic lattice

    CERN Document Server

    Vaman, G

    2014-01-01

    We calculate the electrostatic potential of a periodic lattice of arbitrary extended charges by using the Cartesian multipole formalism. This method allows the separation of the long-range potential from the contact potential (potential on the source). We write both the electrostatic potential and the interaction energy as convergent sums in the reciprocal space.

  3. 7 CFR 1280.224 - Periodic evaluation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Periodic evaluation. 1280.224 Section 1280.224 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE LAMB PROMOTION, RESEARCH,...

  4. Hyperinflation in periodic and quasiperiodic chains

    Science.gov (United States)

    Odagaki, Takashi; Aoyama, Hideaki

    1988-08-01

    A hyperinflation rule is found, which relates one-dimensional systems with different periodicity or quasiperiodicity determined by a parameter α. Physical systems described by transfer matrices are analyzed and the hyperinflation rule is shown to give rise to self-similarity in the space spanned by parameters of the system and α.

  5. On Burnett coefficients in periodic media

    Science.gov (United States)

    Conca, Carlos; Orive, Rafael; Vanninathan, Muthusamy

    2006-03-01

    The aim of this work is to demonstrate a curious property of general periodic structures. It is well known that the corresponding homogenized matrix is positive definite. We calculate here the next order Burnett coefficients associated with such structures. We prove that these coefficients form a tensor which is negative semidefinite. We also provide some examples showing degeneracy in multidimension.

  6. On the Spectrum of Periodic Signals

    Science.gov (United States)

    Al-Smadi, Adnan

    2004-01-01

    In theory, there are many methods for the representation of signals. In practice, however, Fourier analysis involving the resolution of signals into sinusoidal components is used widely. There are several methods for Fourier analysis available for representation of signals. If the signal is periodic, then the Fourier series is used to represent…

  7. Symmetry and resonance in periodic FPU chains

    NARCIS (Netherlands)

    Rink, B.

    2001-01-01

    The symmetry and resonance properties of the Fermi Pasta Ulam chain with periodic boundary conditions are exploited to construct a nearidentity transformation bring ing this Hamiltonian system into a particularly simple form This BirkhoGustavson normal form retains the symmetries of the original sy

  8. Quantum Transport Calculations Using Periodic Boundary Conditions

    OpenAIRE

    Wang, Lin-Wang

    2004-01-01

    An efficient new method is presented to calculate the quantum transports using periodic boundary conditions. This method allows the use of conventional ground state ab initio programs without big changes. The computational effort is only a few times of a normal ground state calculations, thus is makes accurate quantum transport calculations for large systems possible.

  9. Periodic and in-service inspection programs

    International Nuclear Information System (INIS)

    Periodic and in-service inspection programs for Cernavoda NPP consists of periodic inspections of CANDU NPP components CSAN N-285.4 and CSAN N-285.4, in-service inspections and repair and modifications general inspection. Periodic inspection program document (PIPD) determines the systems and components subject to inspection, the category of the inspection, techniques, areas and other details.The current status of the inspection programs is presented, including containment , erosion/corrosion, pressure vessel support and snubbers, main steam lines inspection programs. Qualification program in Cernavoda NPP involves equipment qualification in the on-site laboratory, yearly certification, special equipment qualification in the National Institute of Metrology. All procedures are approved by the ISCIR (regulatory body for pressure vessel and lifting equipment) and CNCAN (National Commission on Nuclear Activities Control). Qualification of the personnel is performed according to the ISCIR Technical prescription CR 11/82 for up to 3 year period. Final qualification and licensing is performed by CNCAN

  10. Culture and Cooperation during the Interwar Period

    OpenAIRE

    Anişoara Popa

    2015-01-01

    Starting from the most important Publications of the International Institute for Intellectual Cooperation (1925-1946) we will explore the ideas concerning culture and personalities involved in the intellectual cooperation during the Interwar Period. Pointing out the role that the International Institute of Intellectual Cooperation had and the Romanian contribution to this cooperation is another purpose of this article.

  11. A Compact Expression for Periodic Instantons

    CERN Document Server

    Cherkis, Sergey A; Zaitsev, Dmitri

    2015-01-01

    Instantons on various spaces can be constructed via a generalization of the Fourier transform called the ADHM-Nahm transform. An explicit use of this construction, however, involves rather tedious calculations. Here we derive a simple formula for instantons on a space with one periodic direction. It simplifies the ADHM-Nahm machinery and can be generalized to other spaces.

  12. Teaching the Hitler Period: History and Morality.

    Science.gov (United States)

    Mork, Gordon R.

    1980-01-01

    Outlines six approaches used in a university history course which address the problems of teaching the Hitler period. The assumption underlying all the approaches is that Americans are not entirely different from Germans and that they may be faced with similar moral choices. The approaches avoid the didactic moralism often taught about this era.…

  13. Modulational instability in periodic quadratic nonlinear materials

    DEFF Research Database (Denmark)

    Corney, Joel Frederick; Bang, Ole

    2001-01-01

    We investigate the modulational instability of plane waves in quadratic nonlinear materials with linear and nonlinear quasi-phase-matching gratings. Exact Floquet calculations, confirmed by numerical simulations, show that the periodicity can drastically alter the gain spectrum but never complete...

  14. Multiwavelength periodicity study of Markarian 501

    CERN Document Server

    Roedig, Constanze; Elbracht, Oliver; Spanier, Felix

    2009-01-01

    Context: Active Galactic Nuclei are highly variable emitters of electromagnetic waves from the radio to the gamma-ray regime. This variability may be periodic, which in turn could be the signature of a binary black hole. Systems of black holes are strong emitters of gravitational waves whose amplitude depends on the binary orbital parameters as the component mass, the orbital semi-major-axis and eccentricity. Aims: It is our aim to prove the existence of periodicity of the AGN Markarian 501 from several observations in different wavelengths. A simultaneous periodicity in different wavelengths provides evidence for bound binary black holes in the core of AGN. Methods: Existing data sets from observations by Whipple, SWIFT, RXTE, VERITAS and MAGIC have been analysed with the Lomb-Scargle method, the epoch folding technique and the SigSpec software. Results: Our analysis shows a 72-day period, which could not be seen in previous works due to the limited length of observations. This does not contradict a 23-day p...

  15. Multispacecraft observations of quasi-periodic emissions

    Science.gov (United States)

    Nemec, Frantisek; Picket, Jolene S.; Santolik, Ondrej

    2014-05-01

    Quasi-periodic (QP) emissions are VLF electromagnetic waves in the frequency range of about 0.5-5 kHz which exhibit a periodic time modulation of the wave intensity. The modulation period is usually on the order of a few tens of seconds. The generation mechanism of these emissions is still not understood, but at least in some cases it appears to be related to ULF magnetic field pulsations which result in periodic modifications of the resonant conditions in the source region. We use multipoint measurements of QP emissions by the 4 Cluster spacecraft. The observations are obtained close to the equatorial region at radial distances of about 4 Earth radii, i.e. close to a possible generation region. A combined analysis of the high resolution data obtained by the WBD instruments and the ULF magnetic field data obtained by the FGM instruments allows for a detailed case-study analysis of these unique emissions. The presented analysis benefits from the recent close-separation configuration of three of the Cluster spacecraft (≡20-100 km) and a related timing analysis, which would be impossible otherwise.

  16. Six Online Periodical Databases: A Librarian's View.

    Science.gov (United States)

    Willems, Harry

    1999-01-01

    Compares the following World Wide Web-based periodical databases, focusing on their usefulness in K-12 school libraries: EBSCO, Electric Library, Facts on File, SIRS, Wilson, and UMI. Search interfaces, display options, help screens, printing, home access, copyright restrictions, database administration, and making a decision are discussed. A…

  17. 34 CFR 668.4 - Payment period.

    Science.gov (United States)

    2010-07-01

    ... periods for an eligible program that measures progress in credit hours and uses standard terms or... measures progress in credit hours and uses standard terms (semesters, trimesters, or quarters), or for a student enrolled in an eligible program that measures progress in credit hours and uses nonstandard...

  18. Localization length of nearly periodic layered metamaterials

    CERN Document Server

    del Barco, O

    2015-01-01

    We have analyzed numerically the localization length of light $\\xi$ for nearly periodic arrangements of homogeneous stacks (formed exclusively by right-handed materials) and mixed stacks (with alternating right and left-handed metamaterials). Layers with index of refraction $n_1$ and thickness $L_1$ alternate with layers of index of refraction $n_2$ and thickness $L_2$. Positional disorder has been considered by shifting randomly the positions of the layer boundaries with respect to periodic values. For homogeneous stacks, we have shown that the localization length is modulated by the corresponding bands and that $\\xi$ is enhanced at the center of each allowed band. In the limit of long-wavelengths $\\lambda$, the parabolic behavior previously found in purely disordered systems is recovered, whereas for $\\lambda \\ll L_1 + L_2$ a saturation is reached. In the case of nearly periodic mixed stacks with the condition $|n_1 L_1|=|n_2 L_2|$, instead of bands there is a periodic arrangement of Lorenztian resonances, ...

  19. Oral phenoxymethylpenicillin treatment during pregnancy

    DEFF Research Database (Denmark)

    Czeizel, A.E.; Rockenbauer, M.; Olsen, Jørn;

    2000-01-01

    The objective of the study was to examine the human teratogenic potential of oral penicillin V: phenoxymethylpenicillin treatment during pregnancy in the large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980–1996. The dataset included 22......, i.e. in the critical period for most major congenital abnormalities in case-matched control pairs. Thus, treatment with oral phenoxymethylpenicillin during pregnancy presents very little if any teratogenic risk to the fetus....

  20. Clinical Study of Tuina Combined with Exercise Therapy in Treatment of Periarthritis of Shoulder in Adhesion Period%推拿配合运动疗法治疗粘连期肩关节周围炎的临床研究

    Institute of Scientific and Technical Information of China (English)

    彭程; 王燕飞

    2012-01-01

    Objective;To study the curative effect and the functional mechanism of treating periarthritis scapulohumera-lis by Tuina and therapeutic exercise. Methods:60 patients were randomly divided into treatment group and control group, 30 in treatment group and others of control group. The treatment group was treated by Tuina and therapeutic exercise, while the control group used pure Tuina manipulation. A comprehensive evaluation on the integral changes of symptoms and physical signs were set up. Results:The Tuina and therapeutic exercise group had a remarkable curative effect compared with the pure Tuina manipulation group. The improvement of the patients'symptoms and physical signs was superior to that of using pure Tuina manipulation ( P < 0. 05 ). Conclusion; Clinical study shows that Tuina combined with therapeutic exercise has a remarkable curative effect. Combined with local anatomy, physiology, pathology and modern research, the functional mechanism may include: releasing muscle and dredging meridians, promoting the circulation of qi and blood, removing spasm and reducing pain. Also, therapeutic exercise can restore the flexibility of interrelated muscles, and plays a role of self adjustment. Two methods complement each other, reflecting the Chinese holism concepts and treating disease roots,making an active role in the curative effect and recurrence for periarthritis scapulohumeralis.%目的:通过临床观察,以探讨推拿配合运动疗法治疗粘连期肩关节周围炎的临床疗效和作用机理.方法:将入选的60例患者随机分为治疗组和对照组,其中治疗组30例,对照组30例.治疗组采用“推拿配合运动疗法”进行治疗,对照组采用单纯推拿治疗.治疗后根据两组症状、体征前后积分值的变化进行综合评价.结果:“推拿配合运动疗法”治疗比单纯手法治疗在疗效和缩短病程方面优势明显;在症状、体征方面改善显著(P<0.05).结论:“推拿配合运动疗法