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Sample records for 4-substituted pent-4-enylamines scope

  1. Expedient Organocatalytic Syntheses of 4-Substituted Pyrazolidines and Isoxazolidines

    Directory of Open Access Journals (Sweden)

    Tarek Yousfi

    2016-12-01

    Full Text Available The efficient organocatalytic synthesis of heterocyclic systems of biological relevance is a subject of growing interest. We have found that the pyrrolidine/benzoic acid-catalyzed reaction of α-substituted propenals such as methacrolein, 2-benzylpropenal and 2-(n-hexylpropenal with activated hydrazines takes place in very good yields (83%–99.6% under very mild conditions to afford 4-substituted pyrazolidin-3-ols (as diastereomer mixtures; subsequent oxidation with PCC affords the corresponding-4-substituted-3-pyrazolidinones in essentially quantitative yields. In a similar way, 4-substituted isoxazolidinones are obtained with N-Cbz-hydroxylamine as a reagent. The use of chiral diarylprolinol trimethylsilyl ethers as catalysts allows the synthesis of several of these compounds in optically active form, in some cases with excellent enantioselectivity (up to 96:4 er. A preliminary evaluation of the biological activity shows that some of these compounds exhibit interesting antibacterial and antifungal activities.

  2. Dihydroxylation of 4-substituted 1,2-dioxines

    DEFF Research Database (Denmark)

    Robinson, Tony V; Pedersen, Daniel Sejer; Taylor, Dennis K;

    2009-01-01

    The synthesis of 2-C-branched erythritol derivatives, including the plant sugar (+/-)-2-C-methylerythritol 2, was achieved through a dihydroxylation/reduction sequence on a series of 4-substituted 1,2-dioxines 3. The asymmetric dihydroxylation of 1,2-dioxines was examined, providing access to opt...

  3. Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines.

    Science.gov (United States)

    Rueping, Magnus; Theissmann, Thomas; Stoeckel, Mirjam; Antonchick, Andrey P

    2011-10-07

    A convenient protocol for the enantioselective synthesis of 4-substituted tetrahydroquinolines has been developed. Chiral BINOL phosphoric acids promote the reduction of a wide range of 4-substituted quinolines with Hantzsch esters with good to high levels of enantioselectivity.

  4. Antifungal activity of 4-substituted crotonic acid esters.

    Science.gov (United States)

    Gershon, H; Shanks, L; Gawiak, D E

    1976-08-01

    Twenty-three 4-substituted crotonic acid esters were tested for antifungal activity against Candida albicans, Aspergillus niger, Mucor mucedo, and Trichophyton mentagrophytes. For the analogues of the methyl ester containing substituents in the 4 position, the following order of fungitoxicity was observed: I greater than Br greater than Cl greater than CH3S greater than CH3O greater than F=H. Of the homologues of the esters of the 4-iodo and 4-bromo compounds which included methyl, ethyl, n-propyl, n-butyl, n-pentyl, and n-hexyl, ethyl 4-iodocrotonate was most toxic to the four fungi at pH 7.0 in the presence of 10% beef serum (C. albicans, 18mug/ml, A. niger, 40 mug/ml, M. mucedo, 5 mug/ml, T. mentagrophytes, 4 mug/ml). It is believed that the mechanism of fungitoxicity is due, in part, to a nucleophilic reaction involving SH-containing compounds. This is based on the correlation of fungitoxicity with the order of leaving groups in the nucleophilic reaction and the protection against the toxicity of the test compounds to the fungi by cysteine and glutathione.

  5. Chiral 4-substituted 2-oxetanones : catalytic stereoselective synthesis, properties and applications

    NARCIS (Netherlands)

    Staring, Aemilianus Gradus Johannes

    1985-01-01

    In this thesis the catalytic stereoselective synthesis of chiral 4-substituted 2-oxetanones described. Chiral 4-substituted 2-oxetanones are formed by a C,C-bond forming cycloaddition reaction of ketene and reactive, alfa-halogenated aldehydes and ketones. The cycloaddition reaction is catalyzed by

  6. Solid-state Synthesis of 1-Ethoxycarbonyl-4-substituted-semicarbazides

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    Hedayat A. Taghizadeh

    2003-04-01

    Full Text Available A rapid and simple method for the preparation of 1-ethoxycarbonyl-4-substituted-semicarbazides has been developed. As examples the reaction of six different isocyanates with ethyl carbazate under solvent-free conditions are reported.

  7. Synthesis of 4-substituted tetrahydropyridines by cross-coupling of enol phosphates

    DEFF Research Database (Denmark)

    Larsen, U.S.; Martiny, L.; Begtrup, M.

    2005-01-01

    Enol phosphates, synthesized from 4-piperidone, react by palladium catalyzed cross-coupling with arylboronic acids and by iron and palladium catalyzed cross-coupling with Grignard reagents to give 4-substituted tetrahydropyridines. (c) 2005 Elsevier Ltd. All rights reserved.......Enol phosphates, synthesized from 4-piperidone, react by palladium catalyzed cross-coupling with arylboronic acids and by iron and palladium catalyzed cross-coupling with Grignard reagents to give 4-substituted tetrahydropyridines. (c) 2005 Elsevier Ltd. All rights reserved....

  8. Synthesis of Novel 1-(4-Substituted pyridine-3-sulfonyl-3-phenylureas with Potential Anticancer Activity

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    Krzysztof Szafrański

    2015-07-01

    Full Text Available A series of novel 4-substituted-N-(phenylcarbamoyl-3-pyridinesulfonamides 11–27 have been synthesized by the reaction of 4-substituted pyridine-3-sulfonamides 2–10 with the appropriate aryl isocyanates in presence of potassium carbonate. The in vitro anticancer activity of compounds 11, 12, 14–21 and 24–26 was evaluated at the U.S. National Cancer Institute and in light of the results, some structure-activity relationships were discussed. The most prominent compound, N-[(4-chlorophenylcarbamoyl]-4-[4-(3,4-dichlorophenylpiperazin-1-yl]pyridine-3-sulfonamide (21 has exhibited a good activity profile and selectivity toward the subpanels of leukemia, colon cancer and melanoma, with average GI50 values ranging from 13.6 to 14.9 µM.

  9. Synthesis of 1S-ethyl-4-substituted quinolizidines and other potentially bioactive compounds

    OpenAIRE

    2012-01-01

    [eng] A dissertation submitted by Vladislav SEMAK to obtain a doctoral degree from University of Barcelona. This thesis was developed under the supervision of Dr. Carmen Escolano Mirón from Faculty of Pharmacy, University of Barcelona. This doctoral thesis is presented as a compendium of publications. The thesis is divided in four chapters: CHAPTER 1 – PART A: Enantioselective, Protecting Group-Free Synthesis of 1S-Ethyl-4-Substituted Quinolizidines (Amat, M.; Semak, V.; Escolano, C....

  10. Biological Activity of 4-Substituted Methoxybenzoyl-Aryl-Thiazole (SMART): An Active Microtubule Inhibitor

    OpenAIRE

    2010-01-01

    Formation of microtubules is a dynamic process that involves polymerization and depolymerization of αβ-tubulin heterodimers. Drugs that enhance or inhibit tubulin polymerization can destroy this dynamic process, arresting cells in the G2/M phase of the cell cycle. Although drugs that target tubulin generally demonstrate cytotoxic potency in the sub-nanomolar range, resistance due to drug efflux is a common phenomenon among the antitubulin agents. We recently reported a class of 4-Substituted ...

  11. Mössbauer spectral studies of Ti{sup 4+} substituted nickel ferrite

    Energy Technology Data Exchange (ETDEWEB)

    Kale, C.M., E-mail: cmk1973@rediffmail.com [Department of Physics, Indraraj Art, Commerce, and Science College, Sillod, Aurangabad (India); Bardapurkar, P.P. [S.N. Arts, D.J. Malpani Commerce and B.N. Sarda Science College, Sangamner (India); Shukla, S.J. [Department of Physics, P.G. Research Centre, Deogiri College, Aurangabad (India); Jadhav, K.M. [Department of Physics, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431001, M.S. (India)

    2013-04-15

    Polycrystalline ferrites with general formula Ni{sub 1+x}Ti{sub x}Fe{sub 2−2x}O{sub 4}, where 0.0≤x≤0.7 were prepared through double sintering ceramic technique using A.R. grade oxides of respective ions. The phase purity of all the samples was checked by X-ray diffraction (XRD) technique. The X-ray diffraction pattern shows all reflections belonging to cubic spinel structure. No extra peak other than cubic spinel was observed in the X-ray diffraction pattern. Using XRD data, the lattice constant was calculated for all the compositions. The lattice constant decreases linearly with Ti{sup 4+} substitutions and obeys Vegard's law. The magnetic properties (saturation magnetization, magneton number, coercivity) were investigated using pulse field hysteresis loop technique at room temperature. The values of coercivity decreases with Ti{sup 4+} content increases. The saturation magnetization and magneton number both significantly decreases with increase in Ti{sup 4+} substitution. Mössbauer spectra of all the samples exhibit sextet. The Mössbauer parameters obtained from Mössbauer spectrum revealed the influence of titanium substitution. -- Highlights: ► XRD synthesis of Ti{sup 4+} substituted spinel structure. ► Non-magnetic Ti{sup 4+} substitution is much effective on magnetic properties. ► Mössbauer spectrum at room temperature influence on hyperfine field for both (A) and [B] sites. ► Zeeman pattern with small isomer shift exhibits small hyperfine field.

  12. Synthesis and antitumor activities of novel 1,4-substituted phthalazine derivatives

    Institute of Scientific and Technical Information of China (English)

    Shu Lan Zhang; Ya Jing Liu; Yan Fang Zhao; Qiu Ting Guo; Ping Gong

    2010-01-01

    A series of 1,4-substituted phthalazine derivatives were designed and synthesized.All the prepared compounds were screened for their cytotoxic activities against A549,HT-29 and MDA-MB-231 cell lines in vitro.Among them,compounds 7a-7h showed excellent selectivity for MDA-MB-231 cell line with IC50 values from 1 nmol/L to 0.92 μmol/L.A preliminary SAR study of these derivatives was performed.

  13. Employing NMR Spectroscopy To Evaluate Transmission of Electronic Effects in 4-Substituted Chalcones

    Science.gov (United States)

    Wachter-Jurcsak, Nanette; Zamani, Hossein

    1999-05-01

    Described is an organic synthesis experiment that demonstrates the electronic transmission by substituents. The effect of substitution at the para-position of the styryl ring of 1,3-diphenyl-2-propenones (chalcones) by typical electron-donating or -accepting groups can be observed by proton and carbon-13 NMR spectroscopy. A linear correlation is observed when the differences in chemical shift measurements for H are plotted against the corresponding Hammett substituent constant values. Good correlation between carbon-13 chemical shifts of the alpha carbon are also observed. The syntheses of the 4-substituted chalcones is presented as well as a brief discussion of the theory.

  14. Reactivity and Regioselectivity in the Heck Reaction - A Hammett Study of 4-Substituted Styrenes

    DEFF Research Database (Denmark)

    Fristrup, Peter; Le Quement, Sebastian; Tanner, David Ackland

    2004-01-01

    The regioselectivity in the cationic Heck reaction of 4-substituted styrenes was addressed by a Hammett study. In this branching reaction, plots based on the substrate reactivity did not give meaningful data, whereas the product distribution was variable due to differing preferences for further...... substitution under the reaction conditions and, thus, unsuitable for Hammett plots. Mechanistically meaningful graphs were obtained by combination of the measured initial branching ratio with the approximately constant substrate reactivity. For the alpha-substitution a clear Hammett relation is observed......, whereas beta-substitution does not depend on electronic effects. This implies that, for alpha-substitution, the slow step of the addition is an electrophilic attack by Pd(II) on the double bond, followed by a rapid migratory insertion....

  15. Recent developments of C-4 substituted coumarin derivatives as anticancer agents.

    Science.gov (United States)

    Dandriyal, Jyoti; Singla, Ramit; Kumar, Manvendra; Jaitak, Vikas

    2016-08-25

    Cancer is a prominent cause of death in global. Currently, the numbers of drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect. Coumarin scaffold became an attractive subject due to their broad spectrum of pharmacological activities. Coumarin derivatives extensively explored for anticancer activities as it possesses minimum side effect along with multi-drug reversal activity. Coumarin derivatives can act by various mechanisms on different tumor cell lines depending on substitution pattern of the core structure of coumarin. Substitution on coumarin nucleus leads to the search for more potent compounds. In this review, we have made an effort to give a synthetic strategy for the preparation of C-4 substituted coumarin derivatives as anticancer agents based on their mechanism of action and also discuss the SAR of the most active compound.

  16. Novel 5-Fluorouracil Derivatives: Synthesis and Cytotoxic Activity of 2-Butoxy-4-Substituted 5-Fluoropyrimidines

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Jian; Zhou, Wei; Hu, Weixiao; Shan, Shang [Zhejiang Univ. of Technology, Hangzhou (China); Zhang, Shijie [Zhejiang Chinese Medical Univ., Hangzhou (China); Li, Haibo [Nantong Center for Disease Control and Prevention, Nantong (China)

    2013-05-15

    Twenty two new 5-fluorouracil (5-FU) derivatives, 2-butoxy-4-substituted 5-fluoropyrimidines, were synthesized and characterized by IR, {sup 1}H NMR, MS, HRMS. All compounds were preliminarily evaluated by MTT assay on human liver BEL-7402 cancer cell line in vitro. Ten compounds were selected to test their cytotoxic activity against A549, HL-60 and MCF-7 cancer cell lines in vitro. These compounds were more sensitive to BEL-7402 than other cell lines, particularly, cytotoxic activity of compounds 6b, 6d-f, 6p, 6s-u were in sub-micromolar scale. The highest cytotoxic potency against A549, HL-60 and MCF-7 was shown by 2-butoxy-4-chloro-5-fluoropyrimidine (5) with IC{sub 50} values of 0.10, 1.66 and 0.59 μM, respectively. Compounds 6d and 6e were effective against MCF-7 with IC{sub 50} 9.73 μM and HL-60 with IC{sub 50} 8.83 μM, respectively.

  17. Synthesis of C-4-Substituted Steviol Derivatives and Their Inhibitory Effects against Hepatitis B Virus.

    Science.gov (United States)

    Lin, Shwu-Jiuan; Su, Ta-Chi; Chu, Chin-Nan; Chang, Yi-Chih; Yang, Li-Ming; Kuo, Yu-Cheng; Huang, Tsurng-Juhn

    2016-12-23

    ent-13-Hydroxykaur-16-ene-19-N-butylureide (6) was one of 33 synthesized C-4-substituted steviol derivatives that were evaluated for their effects on hepatitis B virus (HBV) surface antigen (HBsAg) secretion. The IC50 (16.9 μM) and SI (57.7) values for inhibiting HBV DNA replication of compound 6 were greater than those of the reference compound, lamivudine (3-TC; IC50: 107.5 μM; SI: 22.0). Thus, the anti-HBV mechanism of 6 was investigated, and it specifically inhibited viral gene expression and reduced viral DNA levels, as well as potently attenuated all of the viral promoter activity of HBV-expressing Huh7 cells. Examination of cellular signaling pathways found that 6 inhibited the activities of the nuclear factor (NF)-κB- and activator protein (AP)-1 element-containing promoters, but had no effects on AP-2 or interferon-stimulated response element (ISRE)-containing promoters in HBV-expressing cells. Meanwhile, it significantly eliminated NF-κB and extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling-related protein levels and inhibited their phosphorylation in HBV-transfected Huh7 cells. The inhibitory potency of 6 against HBV DNA replication was reversed by cotransfecting the NF-κB p65 expression plasmid. Using the MAPK-specific activator anisomycin also reversed the inhibitory effect of 6 on viral DNA replication. The present findings suggest that the anti-HBV mechanism of 6 is partly mediated through the NF-κB and MAPK signaling pathways.

  18. Conformational analysis of some N,N-diethyl-2-[(4'-substituted) phenylthio] acetamides.

    Science.gov (United States)

    Vinhato, Elisângela; Olivato, Paulo R; Zukerman-Schpector, Julio; Dal Colle, Maurizio

    2013-11-01

    The conformational analysis of some N,N-diethyl-2[(4'-substituted)phenylthio]acetamides bearing the substituents OMe 1, Me 2, H 3, Cl 4, Br 5 and NO26, was performed by νCO IR analysis, along with B3LYP/6-311++G(d,p) and Polarisable Continuum Model (PCM) calculations, as well as NBO analysis for 1, 3, and 6 and X-ray diffraction for 4. The results of the calculations indicated the existence of two stable conformation pairs, i.e. gauche (anti; syn) (most stable) and cis (anti; syn) in the gas phase. The gauche conformers were less polar with respect to the cis ones for 1 and 3, but more polar for 6. The most intense IR carbonyl doublet component observed at the lower frequency can be ascribed to the gauche conformers g(anti; syn) for 3-6 in n-C6H14, which is in agreement with the gauche and cis relative stabilities and frequencies resulting from the PCM calculations. Similarly, the single IR band for 1 and 2 in n-hexane may be attributed to the gauche conformers. The PCM calculations compared well with the IR data for the compounds in solution, showing that there is a progressive increase of the cis/gauche population ratio as the solvent polarity increases. The NBO analysis indicated that the gauche(anti; syn) conformation in the gas phase was stabilized by the relevant LPS4→πC2O1(∗),πC2O1→σC3S4(∗),σC3S4→πC2O1(∗),πC2O1(∗)→σC3S4(∗), and LPO1→σ(∗)C11H28 orbital interactions, which were absent in the cis(anti; syn) conformer. On the contrary, the cis conformer for derivatives 1, 3, and 6 were stabilized by the σC3-S4(∗)→σ(∗)C2N5 orbital interaction (through bond coupling), along with the additional LPO1→σ(∗)S4C10 interaction for 6. Moreover, the electrostatic repulsion between the C(δ+)S(δ-) and C(δ+)O(δ-) dipoles (Repulsive Field Effect) contributed to both the larger destabilization and increase of the νCO frequency of the cis conformer with respect to the gauche conformer. X-ray single crystal analysis indicates that

  19. A tandem Mannich addition–palladium catalyzed ring-closing route toward 4-substituted-3(2H-furanones

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    Jubi John

    2014-06-01

    Full Text Available A facile route towards highly functionalized 3(2H-furanones via a sequential Mannich addition–palladium catalyzed ring closing has been elaborated. The reaction of 4-chloroacetoacetate esters with imines derived from aliphatic and aromatic aldehydes under palladium catalysis afforded 4-substituted furanones in good to excellent yields. 4-Hydrazino-3(2H-furanones could also be synthesized from diazo esters in excellent yields by utilising the developed strategy. We could also efficiently transform the substituted furanones to aza-prostaglandin analogues.

  20. Planar geometry of 4-substituted-2,2'-bipyridines synthesized by Sonogashira and Suzuki cross-coupling reactions

    Energy Technology Data Exchange (ETDEWEB)

    Luong Thi, T. T., E-mail: thuyltt@hnue.edu.vn; Nguyen Bich, N.; Nguyen, H. [Hanoi National University of Education, Chemistry Department (Viet Nam); Van Meervelt, L., E-mail: luc.vanmeervelt@chem.kuleuven.be [KU Leuven, Chemistry Department (Belgium)

    2015-12-15

    Two 4-substituted 2,2'-bipyridines, namely 4-(ferrocenylethynyl)-2,2'-bipyridine (I) and 4-ferrocenyl-2,2'-bipyridine (II) have been synthesized and fully characterized via single-crystal X-ray diffraction and {sup 1}H and {sup 13}C NMR analyses. The π-conjugated system designed from 2,2'-bipyridine modified with the ferrocenylethynyl and ferrocenyl groups shows the desired planarity. In the crystal packing of I and II, the molecules arrange themselves in head-to-tail and head-to-head motifs, respectively, resulting in consecutive layers of ferrocene and pyridine moieties.

  1. Design and synthesis of 4-substituted quinazolines as potent EGFR inhibitors with anti-breast cancer activity.

    Science.gov (United States)

    Ahmed, Marwa; Magdy, Naja

    2016-09-23

    Cancer is a major health problem to human beings around the world. Many quinazoline derivatives were reported to have potent cytotoxic activity. Our aim in this work is the discovery of potent epidermal growth factor receptor (EGFR) inhibitors with anti-breast cancer activity containing 4-substituted quinazoline pharmacophore. Novel series of 4-substituted 6,8-dibromo-2-(4-chlorophenyl)-quinazoline derivatives have been designed and synthesized. New derivatives were tested against MCF-7 (human breast carcinoma cell line) and screened for their inhibition activity against epidermal growth factor receptor tyrosine kinase (EGFR-TK). Most of the tested compounds show potent antiproliferative activity and EGFR-TK inhibitory activity. Compounds VIIIc and VIIIb exerted powerful cytotoxic activity (IC50 3.1 and 6.3 µM) with potent inhibitory percent (91.1 and 88.4%) against EGFR-TK. Compounds IX, VIIa, X, VIIb, VIc, V, IV, VIa and VIb showed promising cytotoxic effects with IC50 range (12-79 µM) with good activity against EGFR-TK with the inhibitory percent (85.4-60.8%). On the other hand, compounds VIIc, VIIIa exerted low cytotoxic effects as revealed from their IC50 value (124 and 144 µM) with low activity against EGFR-TK with inhibitory percent 30.6 and 29.1% respectively.

  2. ESI-MS spectra of 3-cyano-4-(substituted phenyl-6-phenyl-2(1H-pyridinones

    Directory of Open Access Journals (Sweden)

    BRATISLAV Ž. JOVANOVIĆ

    2009-03-01

    Full Text Available Twelve 3-cyano-4-(substituted phenyl-6-phenyl-2(1H-pyridinones were investigated by tandem mass spectrometry using positive as well as negative electrospray ionization. The influence of the electron affinity of the substituent and the steric effect on the fragmentation is discussed. Pyridinones with a substituent of low proton affinity show loss of water, HCN or benzene from the pyridinone ring in the first step of MS2 fragmentations. Oppositely, if a substituent with high proton affinity is present on the phenyl ring in the 4-position of pyridinone, the fragmentation paths are complex, depending mainly on the substituent proton acceptor ability. Elimination of neutral molecules CO, HCN, H2O, PhH (benzene or Ph and CN radicals are fragmentation processes common for all compounds in the subsequent steps of the fragmentations.

  3. Synthesis, structure characterization and antimicrobial evaluation of 4-(substituted phenylazo)-3,5-diacetamido-1H-pyrazoles.

    Science.gov (United States)

    Kinali-Demirci, Selin; Demirci, Serkan; Kurt, Mustafa

    2013-04-01

    The present article deals with the synthesis, spectral characterization and antimicrobial activity of phenylazo dyes. All of the synthesized phenylazo dyes were characterized using ATR-FTIR, FT-Raman, (1)H NMR, (13)C NMR, elemental analysis and mass spectroscopic techniques. Solvent effects on the UV-Vis absorption spectra of these phenylazo dyes were studied. Acid and base effects on the visible absorption maxima of the phenylazo dyes were also reported. The structural and spectroscopic analysis of the molecules were carried out using Density Functional Theory (DFT) employing the standard 6-31G(d) basis set, and the optimized geometries and calculated vibrational frequencies were evaluated via comparison with experimental values. The antimicrobial activity of 4-(substituted phenylazo)-3,5-diacetamido-1H-pyrazoles was reported against bacteria, including B. cereus (RSKK 863), S. aureus (ATCC 259231), M. luteus (NRRL B-4375), E. coli (ATCC 11230) and the yeast C. albicans (ATCC 10239).

  4. Synthesis, characterization and biological activity of new cyclization products of 3-(4-substituted benzylidene)-2-pyrido[1,2-]pyrimidine 2,4-(3)-diones

    Indian Academy of Sciences (India)

    Abha Bishnoi; Suruchi Singh; Anil K Tiwari; Krishna Srivastava; Ram Raghuvir; Chandrakant M Tripathi

    2013-03-01

    A method is presented for the synthesis of 4-(substituted phenyl)-3-(3-substituted phenyl)4-spiro[isoxazole-5,3'-pyrido[1,2-]pyrimidine]-2',4'-dione (3), 3-(4-substituted phenyl)-3-isoxazole[3, 4-]pyrido[1,2-]pyrimidin-4-(3a)-one (4) and 3-(4-substituted phenyl) 3,3a-dihydropyrazolo[3,4-]pyrido[1,2-]pyrimidin-4-(2)-one (5) which consists of the conversion of 2-pyrido[1,2-]pyrimidine-2,4(3)-dione (1) to chalcones (2) and their 1,3-dipolar cycloaddition with appropriate aldoximes to give spiro compounds and heterocyclization using amines to yield isoxazolines and pyrazolines. All the compounds were screened for their antimicrobial and antitubercular activity.

  5. In vitro cytotoxic, antibacterial, antifungal and urease inhibitory activities of some N4- substituted isatin-3-thiosemicarbazones.

    Science.gov (United States)

    Pervez, Humayun; Iqbal, Mohammad S; Tahir, Muhammad Younas; Nasim, Faiz-ul-Hassan; Choudhary, Muhammad Iqbal; Khan, Khalid Mohammed

    2008-12-01

    A series of 15 previously reported N(4)-substituted isatin-3-thiosemicarbazones 3a-o has been screened for cytotoxic, antibacterial, antifungal and urease inhibitory activities. Compounds 3b, 3e and 3n proved to be active in cytotoxicity assay; 3e exhibited a high degree of cytotoxic activity (LD(50) = 1.10 x 10(-5) M). Compound 3h exhibited significant antibacterial activity against B. subtilis, whereas compounds 3a, 3k and 3l displayed significant antifungal activity against one or more fungal strains i.e. T. longifusus, A. flavus and M. canis. In human urease enzyme inhibition assay, compounds 3g, 3k and 3m proved to be the most potent inhibitors, exhibiting relatively pronounced inhibition of the enzyme. These compounds, being non-toxic, could be potential candidates for orally effective therapeutic agents to treat certain clinical conditions induced by bacterial ureases like H. pylori urease. This study presents the first example of inhibition of urease by isatin-thiosemicarbazones and as such provides a solid basis for further research on such compounds to develop more potent inhibitors.

  6. Synthesis and antimicrobial activity of N1-(3-chloro-4-fluorophenyl-N4-substituted semicarbazone derivatives

    Directory of Open Access Journals (Sweden)

    Mohamed Jawed Ahsan

    2016-09-01

    Full Text Available A series of 16 N1-(3-chloro-4-fluorophenyl-N4-substituted semicarbazone derivatives were synthesized and subjected to computational pharmacokinetic studies to predict molecular properties. All the title compounds (4a–p followed the Lipinski “Rule of Five”. The synthesized compounds were characterized by elemental analyses and spectral data and the compounds (4a–p were evaluated for antimicrobial activities. Among them the compound 2-(4-hydroxybenzylidene-N-(3-chloro-4-fluorolphenylhydrazinecarboxamide (4f was found to be the most active compound that showed good antibacterial activity while the compound 2-(4-methoxybenzylidene-N-(3-chloro-4-fluorolphenylhydrazinecarboxamide (4g was moderately active against fungal strains. We have noticed that the compounds, (4f, 4k and 4d bearing OH and NO2 groups on the phenyl ring at position 4 exhibited good antibacterial activity while compound (4g bearing OCH3 on the phenyl ring at position 4 exhibited moderate antifungal activity.

  7. Synthesis and anticancer activities of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline derivatives.

    Science.gov (United States)

    Zhang, Ying; Huang, Yin-Jiu; Xiang, Hong-Mei; Wang, Pei-Yi; Hu, De-Yu; Xue, Wei; Song, Bao-An; Yang, Song

    2014-05-01

    A series of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline was prepared by conventional heating methods. Among these compounds, the crystal structure of compound 10o (CCDC: 916922) was determined by X-ray crystallography. Bioassay results showed that most target compounds had certain inhibition activities against proliferation of tumor cells, and some compounds even had good broad-spectrum inhibition activities. The ethoxyl series of compounds possessed higher inhibition activities against tumor cells than the methoxyl series of compounds. Bioactivity tests showed that the IC50 values of compound 10s against PC3, MGC803, A375, and A549 cells were 1.8, 2.8, 1.3, and 2.9 μΜ, respectively, which were much higher than those of commercial gefitinib (7.2, 7.6, 7.2, and 9.8 μM, respectively). Conversely, the IC50 values of compound 10s were very low against NH3T3, indicating only weak effect on normal cells as also proven by lactate dehydrogenase and acridine orange/ethidium bromide staining. Analyses of cell configuration and cell cycle revealed that compound 10s possibly caused cells to remain at G0/G1 phase by inhibiting cell proliferation for 24 h. Compound 10s also inhibited the phosphorylation of ERK1/2 and P38 with obvious concentration dependence. Thus, these compounds can inhibit the proliferation of A549 cells through the interruption of ERK1/2 and P38signaling pathways.

  8. Scope ambiguities and conditionals

    NARCIS (Netherlands)

    Over, David; Douven, Igor; Verbrugge, Sara

    2013-01-01

    Scope ambiguities in natural language have been much discussed by linguists and philosophers. There has been some psychological work on the scope ambiguities of negation, but we present the first experiments on modal scope ambiguities in conditionals, with special attention paid to the scope ambigui

  9. Identification and pharmacological characterization of a series of new 1H-4-substituted-imidazoyl histamine H3 receptor ligands.

    Science.gov (United States)

    Yates, S L; Phillips, J G; Gregory, R; Pawlowski, G P; Fadnis, L; Khan, M A; Ali, S M; Tedford, C E

    1999-05-01

    A new series of 1H-4-substituted imidazole compounds were synthesized and identified as potent and selective histamine (HA) H3 receptor ligands. These ligands establish that HA H3 antagonists exhibit stereoselective and conformational preferences in their binding to the HA H3 receptor. Structure-activity relationships were determined in vitro by HA H3 receptor-binding affinities using [3H]Nalpha-methylhistamine and rat cerebral cortical tissue homogenates. Several derivatives containing olefin, amide, and acetylene functional groups were identified as potent HA H3 receptor ligands. In the olefin series, GT-2227 (4-(6-cyclohexylhex-cis-3-enyl)imidazole) was identified as a potent HA H3 receptor ligand with a Ki of 4.2 +/- 0.6 nM, while the trans isomer (GT-2228) displayed a reduced potency (Ki = 15.2 +/- 2.4 nM). GT-2227 was also found to have excellent central nervous system penetration in an ex vivo binding paradigm (ED50 = 0.7 mg/kg i.p.). In the acetylene series, GT-2260 and GT-2286 both exhibited high affinity (Ki = 2.9 +/- 0.2 and 0.95 +/- 0.3 nM) and excellent central nervous system penetration profiles (ED50 = 0.43 and 0.48 mg/kg i.p., respectively). As a prototype for the series, GT-2227 showed high affinity for the human HA H3 receptor (3.2 nM) and minimal affinity for the human HA H1 (Ki = 13,407 +/- 540 nM) and H2 (Ki = 4,469 +/- 564 nM) receptor subtypes. GT-2227 also showed good selectivity for the HA H3 receptor over a broad spectrum of other neurotransmitter receptors (IC50 >/= 1 microM). Furthermore, GT-2227 improved acquisition in a cognitive paradigm without behavioral excitation or effect on spontaneous locomotor activity. In summary, the present studies demonstrate the development of novel HA H3-selective ligands, and lend support for the use of such agents in the treatment of disorders associated with cognitive or attentional deficits.

  10. Synthesis and Antimicrobial Activity of 2-[4-(Substituted Benzylidenamino-5-(Substituted Phenoxymethyl-4H-1,2,4-Triazol-3-yl thio] Acetic Acid Derivatives

    Directory of Open Access Journals (Sweden)

    R. D. Hunashal

    2012-01-01

    Full Text Available 2-[4-(substituted benzylidenamino-5-(substituted phenoxymethyl-4H-1,2,4-triazol-3-yl thio] acetic acid (3a-j derivatives have been synthesized by the reaction between 4-(substituted benzylidenamino-5-(substituted phenoxymethyl-2H-1,2,4-triazol-3(4H-thiones (2a-j and chloroacetic acid containing catalytic amount of pyridine. All these compounds were screened for antimicrobial activity. The compounds 3h and 3j exhibited good antifungal activity against A. niger, C. Neoformans, and A. fumigatus at MIC of 0.25 μg/ml compared to standard drug fluconazole at MIC of 1 μg/mL.

  11. Gas chromatography/mass spectrometric study of non-commercial C-4-substituted 1,4-dihydropyridines and their oxidized derivatives.

    Science.gov (United States)

    López-Alarcón, C; Squella, J A; Núñez-Vergara, Luis J; Baez, H; Camargo, Cristián

    2002-01-01

    A gas chromatography/mass spectrometry (GC/MS) method for the qualitative and quantitative determination of the calcium-channel antagonists C-4-substituted 1,4-dihydropyridines, and their corresponding N-ethyl derivatives, is presented. Also, the electrochemical oxidation and the reactivity of the compounds with alkyl radicals derived from 2,2'-azobis-(2-amidinopropane) were monitored by GC/MS. Mass spectral fragmentation patterns for the C-4-substituted 1,4-dihydropy-ridine parent drugs were significantly different from those of their oxidation products, generated either by electrochemical oxidation or by reaction with alkyl radicals. However, for N-ethyl-1,4-dihydropyridine compounds it was not possible to detect the final products (pyridinium salts) using these experimental conditions. Copyright 2002 John Wiley & Sons, Ltd.

  12. Beta-hydroxyphosphonate ribonucleoside analogues derived from 4-substituted-1,2,3-triazoles as IMP/GMP mimics: synthesis and biological evaluation

    Science.gov (United States)

    Nguyen Van, Tai; Hospital, Audrey; Lionne, Corinne; Jordheim, Lars P; Dumontet, Charles; Périgaud, Christian; Chaloin, Laurent

    2016-01-01

    Summary A series of seventeen β-hydroxyphosphonate ribonucleoside analogues containing 4-substituted-1,2,3-triazoles was synthesized and fully characterized. Such compounds were designed as potential inhibitors of the cytosolic 5’-nucleotidase II (cN-II), an enzyme involved in the regulation of purine nucleotide pools. NMR and molecular modelling studies showed that a few derivatives adopted similar structural features to IMP or GMP. Five derivatives were identified as modest inhibitors with 53 to 64% of cN-II inhibition at 1 mM. PMID:27559400

  13. Regioselective synthesis and anti-HIV activity of the novel 2- and 4- substituted pyrazolo [4,5-e] [ 1,2,4]thiadiazines

    Institute of Scientific and Technical Information of China (English)

    Xin Yong Liu; Ren Zhang Yan; Nian Gen Chen; Wen Fang Xu

    2007-01-01

    The new regioisomer 7-methyl-pyrazolo[4,5-e] [1,2,4]thiadiazine nucleus (5) was synthesized, and its novel mono-N2- or N4-substituted pyrazolo[4,5-e][1,2,4]thiadiazines (6, 7) were regioselectively prepared by deprotonation of N2 or/and N4 atoms with different molar ratio of NaH and alkyl halides. Anti-HIV-1 screening tests showed some compounds to be potent as HIV-1 nonnucleoside reverse transcriptase inhibitors (HIV-1 NNRTIs).(C) 2006 Xin Yong Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  14. Synthesis of 4-substituted oxazolo[4,5-c]quinolines by direct reaction at the C-4 position of oxazoles.

    Science.gov (United States)

    Akula, Mahesh; Thigulla, Yadagiri; Davis, Connor; Jha, Mukund; Bhattacharya, Anupam

    2015-03-07

    A facile synthesis of 4-aryl substituted oxazolo[4,5-c]quinolines has been described via a modified Pictet-Spengler method and using Cu(TFA)2 as a catalyst. The developed methodology directly functionalizes the C-4 position of oxazoles without the aid of any prefunctionalization, in the presence of the more reactive C-2 position in good yields. The versatility of the established method has been demonstrated by its application in the synthesis of 4-substituted oxazolo-[1,8]naphthyridine ring systems.

  15. Synthesis of N1-3-{(4-Substituted aryl-3-chloro-2-oxo- azetidine)-iminocarbamyl}-propyl-6-nitroindazole Derivatives and Their Biological Significance%Synthesis of N1-3-{(4-Substituted aryl-3-chloro-2-oxo- azetidine)-iminocarbamyl}-propyl-6-nitroindazole Derivatives and Their Biological Significance

    Institute of Scientific and Technical Information of China (English)

    Samadhiya, Pushkal; Sharma, Ritu; Srivastava, Santosh K.; Srivastava, Savitri D.

    2011-01-01

    Synthesis of N1-3-{(4-substitute daryl-3-chloro-2-oxo-azetidine)-iminocarbamyl}-propyl-6-nitroindazole 4a-- 4s was conducted by a conventional method. All the compounds were synthesized and characterized by IR, 1H NMR, 13C NMR, FAB-Mass techniques and chemical methods. All the final synthesized compounds were evaluated for their antimicrobial activity and antitubercular activity with MIC values against some selected microorganisms.

  16. Scope Processing in Chinese

    Science.gov (United States)

    Zhou, Peng; Gao, Liqun

    2009-01-01

    The standard view maintains that quantifier scope interpretation results from an interaction between different modules: the syntax, the semantics as well as the pragmatics. Thus, by examining the mechanism of quantifier scope interpretation, we will certainly gain some insight into how these different modules interact with one another. To observe…

  17. Design, synthesis, pharmacological evaluation and computational studies of 1-(biphenyl-4-yl)-2-[4-(substituted phenyl)-piperazin-1-yl]ethanones as potential antipsychotics.

    Science.gov (United States)

    Bhosale, Sharad H; Kanhed, Ashish M; Dash, Radha Charan; Suryawanshi, Mugdha R; Mahadik, K R

    2014-03-03

    This article describes the design of biphenyl moiety linked with aryl piperazine and syntheses of fourteen 1-(biphenyl-4-yl)-2-[4-(substituted phenyl)-piperazin-1-yl]ethanone derivatives along with their pharmacological evaluation for antipsychotic activity and computational studies including quantitative structure activity relationship (QSAR) and descriptor based similarity study. All compounds were found to exhibit considerable anti-dopaminergic and anti-serotonergic activity in behavioural models. Among all derivatives, compound 1-(biphenyl-4-yl)-2-[4-(2-methoxyphenyl)-piperazin-1-yl]ethanone (3c) and 1-(biphenyl-4-yl)-2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]ethanone (3k) showed impressive antipsychotic profile with lower potency for catalepsy induction. These results were found to be sturdily matching with docking study in designing of compounds with homology model of human dopamine D2 receptor. Also the QSAR study strongly supports the obtained results.

  18. Spectroscopic and X-ray crystallographic evidence for electrostatic effects in 4-substituted cyclohexanone-derived hydrazones, imines, and corresponding salts.

    Science.gov (United States)

    Dibble, David J; Ziller, Joseph W; Woerpel, K A

    2011-10-07

    The axial conformer of several 4-substituted cyclohexanone hydrazone salts was found to predominate in solution. Changes in the charge of the molecule and the polarity of the solvent led to changes in the conformational preference of each molecule that were consistent with electrostatic stabilization of the axial conformer. (1)H NMR spectroscopic analysis was utilized to determine the structure of cyclohexanone-derived substrates by comparison to conformationally restricted trans-decalone derivatives and computational models. X-ray crystallography demonstrated that the axial configuration of a pendant benzyloxy group is the preferred conformation of an iminium ion in the solid state. The structure of a neutral hydrazone was also determined to favor the axial configuration for a pendant benzyloxy group in the solid state.

  19. Mass Spectrometric Fragmentation of 1,8-Bis[4-substituted-(oxazolin-2-yl)] anthracenes: Ring-contraction Rearrangement of Oxazoline Ring under Electron-Impact Ionization Conditions

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The mass spectrometric fragmentation of 1,8-bis[4-substituted(oxazolin-2-yl)] anthracenes(AnBOXes) was investigated by using mass-analyzed ion kinetic energy spectrometry under electron-impact ionization conditions. All the compounds could undergo a ring contraction by the loss of an RCH=CH2 molecule to form 1-oxazirinyl-8-(oxazolin-2-yl) anthracene ions, which could further lose an R radical, followed by the loss of oxazoline. These ions could also eliminate an R radical and subsequently undergo ring-contraction rearrangements to lose a CHCH2O fragment and an epoxide molecule, respectively. The ions that are formed could further lose CHCH2O and CH2=CH fragments. Several ring-contraction rearrangements of the oxazoline ring were observed under electron-impact ionization conditions.

  20. Design, Synthesis and Biological Evaluation of 6-(2,6-Dichloro-3,5-dimethoxyphenyl-4-substituted-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors

    Directory of Open Access Journals (Sweden)

    Zhen Zhang

    2016-10-01

    Full Text Available Tyrosine kinase fibroblast growth factor receptor (FGFR, which is aberrant in various cancer types, is a promising target for cancer therapy. Here we reported the design, synthesis, and biological evaluation of a new series of 6-(2,6-dichloro-3,5-dimethoxyphenyl-4-substituted-1H-indazole derivatives as potent FGFR inhibitors. The compound 6-(2,6-dichloro-3,5-dimethoxyphenyl-N-phenyl-1H-indazole-4-carboxamide (10a was identified as a potent FGFR1 inhibitor, with good enzymatic inhibition. Further structure-based optimization revealed that 6-(2,6-dichloro-3,5-dimethoxyphenyl-N-(3-(4-methylpiperazin-1-ylphenyl-1H-indazole-4-carboxamide (13a is the most potent FGFR1 inhibitor in this series, with an enzyme inhibitory activity IC50 value of about 30.2 nM.

  1. Design, Synthesis and Biological Evaluation of 6-(2,6-Dichloro-3,5-dimethoxyphenyl)-4-substituted-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors.

    Science.gov (United States)

    Zhang, Zhen; Zhao, Dongmei; Dai, Yang; Cheng, Maosheng; Geng, Meiyu; Shen, Jingkang; Ma, Yuchi; Ai, Jing; Xiong, Bing

    2016-10-23

    Tyrosine kinase fibroblast growth factor receptor (FGFR), which is aberrant in various cancer types, is a promising target for cancer therapy. Here we reported the design, synthesis, and biological evaluation of a new series of 6-(2,6-dichloro-3,5-dimethoxyphenyl)-4-substituted-1H-indazole derivatives as potent FGFR inhibitors. The compound 6-(2,6-dichloro-3,5-dimethoxyphenyl)-N-phenyl-1H-indazole-4-carboxamide (10a) was identified as a potent FGFR1 inhibitor, with good enzymatic inhibition. Further structure-based optimization revealed that 6-(2,6-dichloro-3,5-dimethoxyphenyl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-indazole-4-carboxamide (13a) is the most potent FGFR1 inhibitor in this series, with an enzyme inhibitory activity IC50 value of about 30.2 nM.

  2. Scope and Sequence.

    Science.gov (United States)

    Callison, Daniel

    2002-01-01

    Discusses scope and sequence plans for curriculum coordination in elementary and secondary education related to school libraries. Highlights include library skills; levels of learning objectives; technology skills; media literacy skills; and information inquiry skills across disciplines by grade level. (LRW)

  3. RADAR PPI Scope Overlay

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — RADAR PPI Scope Overlays are used to position a RADAR image over a station at the correct resolution. The archive maintains several different RADAR resolution types,...

  4. Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3

    DEFF Research Database (Denmark)

    Alaux, Sebastien; Kusk, Mie; Sagot, Emanuelle;

    2005-01-01

    compounds were evaluated as potential ligands for the glutamate transporters EAAT1, EAAT2, and EAAT3 (excitatory amino acid transporter, subtypes 1-3) in the FLIPR membrane potential (FMP) assay. We found a distinct change in the pharmacological profile when the 4-methyl group (compound 1a, an EAAT1......A series of nine L-2,4-syn-4-alkylglutamic acid analogues (1a-i) were synthesized in high yield and high enantiomeric excess (>99% ee) from their corresponding 4-substituted ketoglutaric acids (2a-i), using the enzyme aspartate aminotransferase (AAT) from pig heart or E. coli. The synthesized...... substrate and EAAT2,3 inhibitor) was extended to a 4-ethyl group, compound 1b, as this analogue is an inhibitor at all three subtypes, EAAT1-3. Furthermore, we conclude that both large and bulky hydrophobic substituents in the 4-position of L-2,4-syn Glu are allowed by all three glutamate transporter...

  5. Novel high-affinity and selective biaromatic 4-substituted gamma-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies.

    Science.gov (United States)

    Høg, Signe; Wellendorph, Petrine; Nielsen, Birgitte; Frydenvang, Karla; Dahl, Ivar F; Bräuner-Osborne, Hans; Brehm, Lotte; Frølund, Bente; Clausen, Rasmus P

    2008-12-25

    Gamma-hydroxybutyrate (GHB) is a metabolite of gamma-aminobutyric acid (GABA) and has been proposed to function as a neurotransmitter or neuromodulator. GHB is used in the treatment of narcolepsy and is a drug of abuse. GHB binds to both GABA(B) receptors and specific high-affinity GHB sites in brain, of which the latter have not been linked unequivocally to function, but are speculated to be GHB receptors. In this study, a series of biaromatic 4-substituted GHB analogues, including 4'-phenethylphenyl, 4'-styrylphenyl, and 4'-benzyloxyphenyl GHB analogues, were synthesized and characterized pharmacologically in a [3H](E,RS)-(6,7,8,9-tetrahydro-5-hydroxy-5H-benzocyclohept-6-ylidene)acetic acid ([3H]NCS-382) binding assay and in GABA(A) and GABA(B) receptor binding assays. The compounds were selective for the high-affinity GHB binding sites and several displayed Ki values below 100 nM. The affinity of the 4-[4'-(2-iodobenzyloxy)phenyl] GHB analogue 17b was shown to reside predominantly with the R-enantiomer (Ki = 22 nM), which has higher affinity than previously reported GHB ligands.

  6. Synthesis and antimosquito properties of 2,6-substituted benzo[d]thiazole and 2,4-substituted benzo[d]thiazole analogues against Anopheles arabiensis.

    Science.gov (United States)

    Venugopala, Katharigatta Narayanaswamy; Krishnappa, Manjula; Nayak, Susanta K; Subrahmanya, Bhat K; Vaderapura, Jayashankaragowda P; Chalannavar, Raju K; Gleiser, Raquel M; Odhav, Bharti

    2013-07-01

    A novel and efficient one pot synthesis was developed for 2,6-substituted-benzo[d]thiazole analogues 4a-k and 2,4-substituted-benzo[d]thiazole analogues 4l-pvia three component condensation reaction of substituted arylaldehyde, 2-amino-6-halo/4-methyl-benzo[d]thiazole and 2-naphthol or 6-hydroxyquinoline in presence of 10% w/v NaCl in water by microwave method. This method enabled for short reaction times, easy work-up and significant high yields. The title compound 4b was used for single crystal X-ray studies in order to understand its conformation and packing features. The title compounds 4a-p were screened for antimosquito properties such as repellency, insecticidal and larvicidal activity against Anopheles arabiensis by mosquito feeding-probing assay, cone bio-assay and standard WHO larvicidal assay, respectively. Among these analogous 4b, 4d and 4p exhibit the highest repellent activity comparable to the positive control DEET, and 4a and 4k knockdown most mosquitoes on repellent assays.

  7. ESR, electrochemical, molecular modeling and biological evaluation of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones as potential anti- Trypanosoma cruzi agents

    Science.gov (United States)

    Aguilera-Venegas, Benjamín; Olea-Azar, Claudio; Norambuena, Ester; Arán, Vicente J.; Mendizábal, Fernando; Lapier, Michel; Maya, Juan Diego; Kemmerling, Ulrike; López-Muñoz, Rodrigo

    2011-03-01

    Electrochemical and ESR studies were carried out in this work with the aim of characterizing the reduction mechanisms of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones by means of cyclic voltammetry in DMSO as aprotic solvent. Two reduction mechanisms were found for these compounds: the first, for compounds bearing a labile hydrogen by following a self-protonation mechanism (ECE steps), and the second, for compounds without labile hydrogen, based on a purely electrochemical reduction mechanism (typical of nitroheterocycles). The electrochemical results were corroborated using ESR spectroscopy allowing us to propose the hyperfine splitting pattern of the nitro-radical, which was later corroborated by the ESR simulation spectra. All these compounds were assayed as growth inhibitors against Trypanosoma cruzi: first, on the non-proliferative (and infective) form of the parasite (trypomastigote stage), and then, the ones that displayed activity, were assayed on the non-infective form (epimastigote stage). Thus, we found four new compounds highly active against T. cruzi. Finally, molecular modeling studies suggest the inhibition of the trypanothione reductase like one of the possible mechanisms involved in the trypanocidal action.

  8. Synthesis and potential antitumor activity of 7-(4-substituted piperazin-1-yl)-4-oxoquinolines based on ciprofloxacin and norfloxacin scaffolds: in silico studies.

    Science.gov (United States)

    Abdel-Aziz, Alaa A-M; El-Azab, Adel S; Alanazi, Amer M; Asiri, Yousif A; Al-Suwaidan, Ibrahim A; Maarouf, Azza R; Ayyad, Rezk R; Shawer, Taghreed Z

    2016-10-01

    The potential antitumor activities of a series of 7-(4-substituted piperazin-1-yl)fluoroquinolone derivatives (1-14a,b) using ciprofloxacin and norfloxacin as scaffolds are described. These compounds exhibit potent and broad spectrum antitumor activities using 60 human cell lines in addition to the inherent antibacterial activity. Compounds 1a, 2a, 3b, 6b and 7a were found to be the most potent, while 2b, 5b, and 6a were found to have an average activity. The results of this study demonstrated that compounds 1a, 2a, 3b, 6b and 7a (mean GI50; 2.63-3.09 µM) are nearly 7-fold more potent compared with the positive control 5-fluorouracil (mean GI50; 22.60 µM). More interestingly, compounds 1a, 2a, 3b, 6b and 7a have an almost antitumor activity similar to gefitinib (mean GI50; 3.24 µM) and are nearly 2-fold more potent compared to erlotinib (mean GI50; 7.29 µM). In silico study and ADME-Tox prediction methodology were used to study the antitumor activity of the most active compounds and to identify the structural features required for antitumor activity.

  9. Synthesis and anti-TMV activity of novel N-(3-alkyl-1H-pyrazol-4-yl)-3-alkyl-4-substituted- 1H-pyrazole-5-carboxamides

    Institute of Scientific and Technical Information of China (English)

    Da Qiang Zhang; Gao Fei Xu; Zhi Jin Fan; Dao Quan Wang; Xin Ling Yang; De Kai Yuan

    2012-01-01

    In oraer to investigate the biological activity of novel bis-pyrazole compounds,a series of N-(3-alkyl-5-(N-methylcarbamyl)-1H-pyrazol-4-yl)-3-alkyl-4-substituted-1H-pyrazole-5-carboxamides were designed and synthesized with ethyl 3-alkyl-1H-pyrazole-5-carboxylate 1 as starting materials.N-Methyl-3-alkyl-4-amino-1H-pyrazole-5-carboxamides 6 were obtained from 1 via 5 steps.3-Alkyl-4-substitued-1H-pyrazole-5-carboxyl chlorides 4a,4b,11a,11b,11c or 12 were also obtained from 1 via several steps.Target compounds 7a-7g were obtained after the reaction of 6 with the above 1H-pyrazole-5-carboxyl chlorides.Preliminary bioassay showed some compounds possessing good inactivation effect against TMV (tobacco mosaic virus).Compound 7a showed higher activity superior to ningnanmycin at a concentration of 5.0 × 10-4 g/mL and equal acdvity at 1.0 × 10-4 g/nL; 7b and 7c showed equal activity to virazole both at concentrations of 5.0 × 10-4 g/mL and 1.0 × 10-4 g/mL.

  10. Oxidizer Scoping Studies

    Energy Technology Data Exchange (ETDEWEB)

    Chancellor, Christopher John [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-11-07

    The purpose of this report is to present the results of the acceptable knowledge (AK) review of oxidizers present in active waste streams, provide a technical analysis of the oxidizers, and report the results of the scoping study testing. This report will determine the fastest burning oxidizer to be used in the development of a Test Plan for Preparation and Testing of Sorbents Mixed with Oxidizer found in Transuranic Waste (DWT-TP-001). The companion report, DWT-RPT-002, Sorbent Scoping Studies, contains similar information for sorbents identified during the AK review of TRU waste streams. The results of the oxidizer and sorbent scoping studies will be used to inform the QL1 test plan. The QL1 test results will support the development of a basis of knowledge document that will evaluate oxidizing chemicals and sorbents in TRU waste and provide guidance for treatment.

  11. 1, 3-Dipolar cycloaddition reactions: Synthesis of 5-benzyl-1-(2',4'-dibromophenyl)-3-(4"-substituted phenyl)-3a,4,6,6a-tetrahydro-1, 5-pyrrolo[3,4-]pyrazole-4,6-dione derivatives

    Indian Academy of Sciences (India)

    Manpreet Kaur; Baldev Singh; Baljit Singh

    2013-11-01

    1,3-Dipolar cycloaddition of nitrilimines 3 with -benzyl maleimide 4 has provided 5-benzyl-1-(2',4'-dibromophenyl)-3-(4"-substituted phenyl)-3a,4,6,6a-tetrahydro-1,5-pyrrolo[3,4-]pyrazole-4,6-dione derivatives 5 in excellent yield as the only isomer through a concerted pathway.

  12. Design, synthesis and in vitro antibacterial activities of methyl-4-((substituted phenyl) [6H-indolo (2,3-b)quinoxalin-6-yl]methyl-amino)benzoate derivatives

    Institute of Scientific and Technical Information of China (English)

    Yellajyosula Lakshmi Narasimha Murthy; Nagalakshmi Karthikeyan; Govindh Boddeti; Bhagavathula S. Diwakar; E. Rajendra Singh

    2011-01-01

    A series of new methyl-4-((substituted phenyl) [6H-indolo (2,3-b)quinoxalin-6yllmethylamino)benzoate derivatives have been synthesized and assayed for their antibacterial activity on 9 different bacterial strains. Among the screened compounds 2e-2g exhibited potent inhibitory activity compared to standard drug employed, worth further investigation.

  13. Anti-inflammatory and antinociceptive evaluation of newly synthesized 4-(substituted ethanoyl amino-3-mercapto-5-(4-methoxy phenyl-1,2,4-triazoles

    Directory of Open Access Journals (Sweden)

    Neeraj Upmanyu

    2011-01-01

    Full Text Available Introduction: 1,2,4-triazoles and its derivatives have been reported to possess anti-inflammatory, analgesic, antimicrobial, anticancer, antitumor, antitubercular, anticonvulsant, openers of Ca-activated potassium (Maxi-K channels, antiviral properties, hypoglycemic, anxiolytic and antidepressant activity. Therefore, 1,2,4-triazole seems to be an important pharmacophore. Materials and Methods: The synthesis of 4-(substituted ethanoyl amino-3-mercapto-5-(4-methoxy phenyl-1,2,4-triazoles (6a-o were prepared following six step starting 4-methoxy benzoic acid and using different secondary amines and were characterized with the help of FT-IR, 1 H, 13 C NMR, FAB Mass and nitrogen analysis. These synthesized compounds (6a-o were then evaluated for anti-inflammatory activity by carrageenan induced paw edema method.Out of these synthesized compounds, some (6f, i and k were evaluated for antinociceptive activity by Hot plate method and Tail immersion method. Results and Discussion: The synthesis of 4-(substituted amino-3-mercapto-5-(4-methoxy phenyl-1,2,4-triazoles (6a-o was accomplished. The IR spectra exhibited characteristic bands for C-N, C=N, SH and C=O at 1350-1360, 1511-1548, 2520-2594.3 and 1650-1719 cm -1 . The C-O-C asymmetric and symmetric str. was at 1250-1254 and 1027-1079.3 cm -1 respectively. In 1 H-NMR spectra, a singlet of CONH was found in the range of δ 9.92-10.18 ppm and another singlet of thiol group was observed in the range of δ 8.63-9.92 ppm. A singlet of Ar-OCH 3 was also found between δ 3.57-3.91 ppm. In 13 C- NMR spectra, C-3 and C-5 of the 1,2,4 - triazole nucleus were observed in the range of δ 147-166.9 ppm. Carbonyl carbon and methylene carbon of -NHCOCH 2 N< were found between δ 166.5-177.5 and δ 47.1-62 ppm respectively. Acute toxicity study was donr following OECD-423 and cut-off dose was found to be between 1000-1500 mg/kg body weight. At the dose level of 100 mg/kg, 6f, 6i and 6k exhibited appreciable inhibition

  14. Crystal structures of three 4-substituted-2,2′-bipyridines synthesized by Sonogashira and Suzuki–Miyaura cross-coupling reactions

    Directory of Open Access Journals (Sweden)

    Thuy Luong Thi Thu

    2017-04-01

    Full Text Available Facile synthetic routes for three 4-substituted 2,2′-bipyridine derivatives, 4-[2-(4-methylphenylethynyl]-2,2′-bipyridine, C19H14N2, (I, 4-[2-(pyridin-3-ylethynyl]-2,2′-bipyridine, C17H11N3, (II, and 4-(indol-4-yl-2,2′-bipyridine, C18H13N3, (III, via Sonogashira and Suzuki–Miyaura cross-coupling reactions, respectively, are described. As indicated by X-ray analysis, the 2,2′-bipyridine core, the ethylene linkage and the substituents of (I and (II are almost planar [dihedral angles between the two ring systems: 8.98 (5 and 9.90 (6° for the two molecules of (I in the asymmetric unit and 2.66 (14° for (II], allowing π-conjugation. On the contrary, in (III, the indole substituent ring is rotated significantly out of the bipyridine plane [dihedral angle = 55.82 (3°], due to steric hindrance. The crystal packings of (I and (II are dominated by π–π interactions, resulting in layers of molecules parallel to (30-2 in (I and columns of molecules along the a axis in (II. The packing of (III exhibits zigzag chains of molecules along the c axis interacting through N—H...N hydrogen bonds and π–π interactions. The contributions of unknown disordered solvent molecules to the diffraction intensities in (II were removed with the SQUEEZE [Spek (2015. Acta Cryst. C71, 9–18] algorithm of PLATON. The given chemical formula and other crystal data do not take into account these solvent molecules.

  15. Crystal and molecular structure studies of (Z)-N-methyl-C-4-substituted phenyl nitrones by XRD, DFT, FTIR and NMR methods

    Science.gov (United States)

    Lasri, Jamal; Eltayeb, Naser Eltaher; Haukka, Matti; Alghamdi, Yousef

    2017-01-01

    (Z)-N-methyl-C-4-substituted phenyl nitrones -O+N(Me)=C(H)R (Z-2a R = 4-ClC6H4, Z-2b R = 4-NO2C6H4, Z-2c R = 4-CH3OC6H4) were synthesized and characterized by elemental analyses, FTIR, 1H, 13C and DEPT-135 NMR spectroscopy and also by single crystal X-ray diffraction (in the case of Z-2a and Z-2b). The geometries of the nitrone molecules Z-2a, Z-2b and Z-2c and their E-isomers; (E)-N-methyl-C-4-chlorophenyl nitrone E-2a, (E)-N-methyl-C-4-nitrophenyl nitrone E-2b and (E)-N-methyl-C-4-methoxyphenyl nitrone E-2c were optimized using density functional theory (DFT) at the B3LYP/6-311++G(d,p) level of theory. The theoretical vibrational frequencies obtained by DFT calculations are in good agreement with the experimental values. The electronics structures were described in terms of the distribution of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO). Gauge independent atomic orbital (GIAO) method was used to calculate the NMR spectra, the correlation between the calculated and experimental chemical shifts is mostly in the range of 0.94-0.97 for 1H, whereas, the correlation for 13C is 0.99. Thermodynamics study showed that the Z-isomer is favoured than E-isomer with energy barrier of 7.1, 7.2 and 7.1 kcal/mol for Z-2a, Z-2b and Z-2c, respectively. The abundance of the most stable species Z-isomers is equal to 99.99% for all three compounds at 298 K in gas phase.

  16. Cosmetology: Scope and Sequence.

    Science.gov (United States)

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This scope and sequence guide, developed for a cosmetology vocational education program, represents an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System. It was developed as a result of needs expressed by teachers, parents, and the…

  17. Frozen Scope and Grammatical Optimization

    Science.gov (United States)

    Freedman, Michael

    2014-01-01

    The literature on quantifier scope has repeatedly observed that some otherwise expected permutations of scope taking elements are unavailable. Various methods have been proffered explaining these facts. This thesis aims to unify three disparate areas where the scope of operators seems to be frozen: the interaction of universal quantifiers with…

  18. Crystal structures of three 4-substituted-2,2′-bipyridines synthesized by Sonogashira and Suzuki–Miyaura cross-coupling reactions

    Science.gov (United States)

    Luong Thi Thu, Thuy; Nguyen Bich, Ngan; Nguyen, Hien

    2017-01-01

    Facile synthetic routes for three 4-substituted 2,2′-bi­pyridine derivatives, 4-[2-(4-methyl­phenyl)­ethyn­yl]-2,2′-bi­pyridine, C19H14N2, (I), 4-[2-(pyridin-3-yl)ethyn­yl]-2,2′-bi­pyridine, C17H11N3, (II), and 4-(indol-4-yl)-2,2′-bi­pyridine, C18H13N3, (III), via Sonogashira and Suzuki–Miyaura cross-coupling reactions, respect­ively, are described. As indicated by X-ray analysis, the 2,2′-bi­pyridine core, the ethyl­ene linkage and the substituents of (I) and (II) are almost planar [dihedral angles between the two ring systems: 8.98 (5) and 9.90 (6)° for the two mol­ecules of (I) in the asymmetric unit and 2.66 (14)° for (II)], allowing π-conjugation. On the contrary, in (III), the indole substituent ring is rotated significantly out of the bi­pyridine plane [dihedral angle = 55.82 (3)°], due to steric hindrance. The crystal packings of (I) and (II) are dominated by π–π inter­actions, resulting in layers of mol­ecules parallel to (30-2) in (I) and columns of mol­ecules along the a axis in (II). The packing of (III) exhibits zigzag chains of mol­ecules along the c axis inter­acting through N—H⋯N hydrogen bonds and π–π inter­actions. The contributions of unknown disordered solvent mol­ecules to the diffraction intensities in (II) were removed with the SQUEEZE [Spek (2015 ▸). Acta Cryst. C71, 9–18] algorithm of PLATON. The given chemical formula and other crystal data do not take into account these solvent mol­ecules. PMID:28435732

  19. Scoping studies: advancing the methodology

    Directory of Open Access Journals (Sweden)

    O'Brien Kelly K

    2010-09-01

    Full Text Available Abstract Background Scoping studies are an increasingly popular approach to reviewing health research evidence. In 2005, Arksey and O'Malley published the first methodological framework for conducting scoping studies. While this framework provides an excellent foundation for scoping study methodology, further clarifying and enhancing this framework will help support the consistency with which authors undertake and report scoping studies and may encourage researchers and clinicians to engage in this process. Discussion We build upon our experiences conducting three scoping studies using the Arksey and O'Malley methodology to propose recommendations that clarify and enhance each stage of the framework. Recommendations include: clarifying and linking the purpose and research question (stage one; balancing feasibility with breadth and comprehensiveness of the scoping process (stage two; using an iterative team approach to selecting studies (stage three and extracting data (stage four; incorporating a numerical summary and qualitative thematic analysis, reporting results, and considering the implications of study findings to policy, practice, or research (stage five; and incorporating consultation with stakeholders as a required knowledge translation component of scoping study methodology (stage six. Lastly, we propose additional considerations for scoping study methodology in order to support the advancement, application and relevance of scoping studies in health research. Summary Specific recommendations to clarify and enhance this methodology are outlined for each stage of the Arksey and O'Malley framework. Continued debate and development about scoping study methodology will help to maximize the usefulness and rigor of scoping study findings within healthcare research and practice.

  20. Sorbent Scoping Studies

    Energy Technology Data Exchange (ETDEWEB)

    Chancellor, Christopher John [Los Alamos National Lab. (LANL), Carlsbad, NM (United States). Difficult Waste Team

    2016-11-14

    The Los Alamos National Laboratory – Carlsbad Operations (LANL-CO) office was tasked by the DOE CBFO, Office of the Manager to: • Perform a review of the acceptable knowledge (AK) to identify the oxidizers and sorbents in transuranic (TRU) waste streams. • Conduct scoping studies on the oxidizers and sorbents identified in AK review to inform the Quality Level 1 (QL1) testing. • Conduct a series of QL1 tests to provide the scientific data to support a basis of knowledge document for determining the criteria for: 1) accepting waste at the Waste Isolation Pilot Plant (WIPP) without treatment, 2) determining waste that will require treatment, and 3) if treatment is required, how the treatment must be performed. The purpose of this report is to present the results of the AK review of sorbents present in active waste streams, provide a technical analysis of the sorbent list, report the results of the scoping studies for the fastest burning organic sorbent, and provide the list of organic and inorganic sorbents to be used in the development of a Test Plan for Preparation and Testing of Sorbents Mixed with Oxidizer found in Transuranic Waste (DWT-TP-001). The companion report, DWT-RPT-001, Oxidizer Scoping Studies, has similar information for oxidizers identified during the AK review of TRU waste streams. The results of the oxidizer and sorbent scoping studies will be used to inform the QL1 test plan. The QL1 test results will support the development of a basis of knowledge document that will evaluate oxidizing chemicals and sorbents in TRU waste and provide guidance for treatment.

  1. Scoping Agriculture, Wetland Interactions

    OpenAIRE

    2015-01-01

    Agriculture is identified as the main cause of wetland degradation and loss. Using a drivers, pressures, state changes, impacts and responses (DPSIR) framework to analyze 90 cases drawn from all parts of the world and all wetland types, this report assesses the character of agriculture - wetlands interactions (AWIs) and their impacts in socio-economic and ecosystem services terms. The report is a technical framework that is used to scope out the relevance and nature of AWIs, identify response...

  2. Scope of strategic marketing

    Directory of Open Access Journals (Sweden)

    Bradley Frank

    2004-01-01

    Full Text Available Marketing is a philosophy that leads to the process by which organizations, groups and individuals obtain what they need and want by identifying value, providing it, communicating it and delivering it to others. The core concepts of marketing are customers needs, wants and values; products, exchange, communications and relationships. Marketing is strategically concerned with the direction and scope of the long-term activities performed by the organization to obtain a competitive advantage. The organization applies its resources within a changing environment to satisfy customer needs while meeting stakeholder expectations. Implied in this view of strategic marketing is the requirement to develop a strategy to cope with competitors, identify market opportunities, develop and commercialize new products and services, allocate resources among marketing activities and design an appropriate organizational structure to ensure the perform once desired is achieved.

  3. Synthesis and Anti-inflammatory Activity of Some Novel 3-(6-Substituted-1, 3-benzothiazole-2-yl-2-[{(4-substituted phenyl amino} methyl] quinazolines-4 (3H-ones

    Directory of Open Access Journals (Sweden)

    Manish Srivastav

    2009-01-01

    Full Text Available A series of novel 3-(6-substituted-1, 3-benzothiazole-2-yl-2-[{(4-substituted phenyl amino} methyl] quinazolines-4(3H-ones were synthesized by treating 2-(chloromethyl-3-(6-substituted-1, 3-benzothiazole-2-yl quinazoline-4-(3H-one (IIa-d with various substituted amine. The compounds (IIa-d prepared by treating 2-[(chloroacetyl amino] benzoic acid with different 2-amino-6-substituted benzothiazole. Elemental analysis, IR, 1HNMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized quinazolines-4-one derivative were investigated for their anti-inflammatory and antibacterial activity.

  4. Synthesis and Antimicrobial Screening of Novel 4-Substituted Phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]-2H-1,2,4-triazole-3-thiones

    OpenAIRE

    Bhandari, Namratha; Santosh L. Gaonkar

    2014-01-01

    The paper describes a convenient method for the preparation of 4-substituted phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]-2H-1,2,4-triazole-3-thiones. The structures of the synthesized compounds are established by the results of LCMS, 1H NMR, 13C NMR, and IR and elemental analyses. The mercaptotriazoles are indicated to be in thione form by 1H NMR spectra. All the synthesized compounds have been screened for antibacterial and antifungal activities. Compounds 12d and 12h exhibit...

  5. Sustained metabolic scope.

    Science.gov (United States)

    Peterson, C C; Nagy, K A; Diamond, J

    1990-03-01

    Sustained metabolic rates (SusMR) are time-averaged metabolic rates that are measured in free-ranging animals maintaining constant body mass over periods long enough that metabolism is fueled by food intake rather than by transient depletion of energy reserves. Many authors have suggested that SusMR of various wild animal species are only a few times resting (basal or standard) metabolic rates (RMR). We test this conclusion by analyzing all 37 species (humans, 31 other endothermic vertebrates, and 5 ectothermic vertebrates) for which SusMR and RMR had both been measured. For all species, the ratio of SusMR to RMR, which we term sustained metabolic scope, is less than 7; most values fall between 1.5 and 5. Some of these values, such as those for Tour de France cyclists and breeding birds, are surely close to sustainable metabolic ceilings for the species studied. That is, metabolic rates higher than 7 times RMR apparently cannot be sustained indefinitely. These observations pose several questions: whether the proximate physiological causes of metabolic ceilings reside in the digestive tract's ability to process food or in each tissue's metabolic capacity; whether ceiling values are independent of the mode of energy expenditure; whether ceilings are set by single limiting physiological capacities or by coadjusted clusters of capacities (symmorphosis); what the ultimate evolutionary causes of metabolic ceilings are; and how metabolic ceilings may limit animals' reproductive effort, foraging behavior, and geographic distribution.

  6. Networked Microgrids Scoping Study

    Energy Technology Data Exchange (ETDEWEB)

    Backhaus, Scott N. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dobriansky, Larisa [General MicroGrids, San Diego, CA (United States); Glover, Steve [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Liu, Chen-Ching [Washington State Univ., Pullman, WA (United States); Looney, Patrick [Brookhaven National Lab. (BNL), Upton, NY (United States); Mashayekh, Salman [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Pratt, Annabelle [National Renewable Energy Lab. (NREL), Golden, CO (United States); Schneider, Kevin [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Stadler, Michael [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Starke, Michael [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wang, Jianhui [Argonne National Lab. (ANL), Argonne, IL (United States); Yue, Meng [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-12-05

    Much like individual microgrids, the range of opportunities and potential architectures of networked microgrids is very diverse. The goals of this scoping study are to provide an early assessment of research and development needs by examining the benefits of, risks created by, and risks to networked microgrids. At this time there are very few, if any, examples of deployed microgrid networks. In addition, there are very few tools to simulate or otherwise analyze the behavior of networked microgrids. In this setting, it is very difficult to evaluate networked microgrids systematically or quantitatively. At this early stage, this study is relying on inputs, estimations, and literature reviews by subject matter experts who are engaged in individual microgrid research and development projects, i.e., the authors of this study The initial step of the study gathered input about the potential opportunities provided by networked microgrids from these subject matter experts. These opportunities were divided between the subject matter experts for further review. Part 2 of this study is comprised of these reviews. Part 1 of this study is a summary of the benefits and risks identified in the reviews in Part 2 and synthesis of the research needs required to enable networked microgrids.

  7. Synthesis and antifungal activity of 1- ( 1 H-1, 2,4-triazol-1-yl) -2- (2,4-difluorophenyl)-3-(4-substituted acyl piperazin-1-yl)-2-propanols

    Institute of Scientific and Technical Information of China (English)

    LIANG Shuang; LIU Chao-mei; ZHU Jie; HE Qiu-qin; JIANG Yuan-ying; CAO Yong-bin

    2004-01-01

    Objective: To study the effect of fluconzole derivatives from a side chain containing 4-substituted acyl piperazin-1-yl on antifungal activity. Methods: Fourteen title compounds were synthesized and confirmed by the elementary analysis, 1HNMR and IR spectra. Five deep fungal strains and 3 shallow fungal strains were chosen as the experimental strains. Minimum inhibitory concentrations(MICs) of all title compounds were determined by the method recommended by the National Committee for Clinical Laboratory Standards (NCCLS) using RPMI 1640 test medium. Results: Among the 14title compounds, 12 were first reported. The results of preliminary antifungal test showed that all the title compounds exhibited potent antifungal activities to a certain extent. The activity of 4 compounds were more than 4 times as high as that of fluconazole and equal to that of ketoconazole against Candida albicans in vitro(MIC80 value≤0. 125 μg/ml). Conclusion:Introduction of a side chain containing 4-substituted acyl piperazin-l-yl into the main part of fluconazole has important influence on antifungal activities of title compounds.

  8. The Scope of Design Studying

    Institute of Scientific and Technical Information of China (English)

    JIN Yin; Ren Wenying

    2007-01-01

    This article trys to discuss the scope of design studying in two fields.Firstly, design has three meanings: wide design, art design and industrial design.Secondly, design studying has five contents: cultural, philosophical, methodological, produced and marketable trends.

  9. Residential ventilation standards scoping study

    Energy Technology Data Exchange (ETDEWEB)

    McKone, Thomas E.; Sherman, Max H.

    2003-10-01

    The goals of this scoping study are to identify research needed to develop improved ventilation standards for California's Title 24 Building Energy Efficiency Standards. The 2008 Title 24 Standards are the primary target for the outcome of this research, but this scoping study is not limited to that timeframe. We prepared this scoping study to provide the California Energy Commission with broad and flexible options for developing a research plan to advance the standards. This document presents the findings of a scoping study commissioned by the Public Interest Energy Research (PIER) program of the California Energy Commission to determine what research is necessary to develop new residential ventilation requirements for California. This study is one of three companion efforts needed to complete the job of determining the ventilation needs of California residences, determining the bases for setting residential ventilation requirements, and determining appropriate ventilation technologies to meet these needs and requirements in an energy efficient manner. Rather than providing research results, this scoping study identifies important research questions along with the level of effort necessary to address these questions and the costs, risks, and benefits of pursuing alternative research questions. In approaching these questions and corresponding levels of effort, feasibility and timing were important considerations. The Commission has specified Summer 2005 as the latest date for completing this research in time to update the 2008 version of California's Energy Code (Title 24).

  10. 2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies.

    Science.gov (United States)

    Yan, Gang; Hao, Lina; Niu, Yan; Huang, Wenjie; Wang, Wei; Xu, Fengrong; Liang, Lei; Wang, Chao; Jin, Hongwei; Xu, Ping

    2017-09-08

    In this work, a series of 2-substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamide derivatives were developed as β-secretase (BACE-1) inhibitors. Supported by docking study, a small library of derivatives were designed, synthesized and biologically evaluated in vitro. In addition, the selected compounds were tested with affinity (KD) towards BACE-1, blood brain barrier (BBB) permeability and cytotoxicity. The studies revealed that the most potent analog 41 (IC50 = 4.6 μM) with high predicted BBB permeability and low cellular cytotoxicity, could serve as a good lead structure for further optimization. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  11. Synthesis and antihyperlipidemic activity of some novel 4-substituted-2-substitutedmethyltriazino[6,1-b]quinazolin-10-ones and 2,4-disubstituted-6,7-dimethoxy quinazoline

    Directory of Open Access Journals (Sweden)

    M.K. Kathiravan

    2016-09-01

    Full Text Available The synthesis and antihyperlipidemic activity of some novel 4-substituted-2-substitutedmethyltriazino[6,1-b]quinazolin-10-ones and 2,4-disubstituted-6,7-dimethoxy quinazoline derivatives are described. Among the series 4-chloro-2-acetoxymethyl-3H,11H-[1,2,4]triazino[6,1-b] quinazoline-4,10-dione 5d has shown better activity in case of % reduction in serum cholesterol level while 4-chloro-10-oxo-10H-[1,2,4]triazino[6,1-b]quinazolin-2-yl benzoate 5f in reducing % serum triglyceride level than that of the standard. 4-Hydroxyquinazolin-2-yl nicotinate 6g has significantly increased serum HDL level. Among the series compound 6g has shown promising results over all in lipid profile. These molecules indeed have the potential to be developed as an antihyperlipaemic molecule.

  12. Synthesis and Antimicrobial Screening of Novel 4-Substituted Phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]-2H-1,2,4-triazole-3-thiones.

    Science.gov (United States)

    Bhandari, Namratha; Gaonkar, Santosh L

    2014-01-01

    The paper describes a convenient method for the preparation of 4-substituted phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]-2H-1,2,4-triazole-3-thiones. The structures of the synthesized compounds are established by the results of LCMS, (1)H NMR, (13)C NMR, and IR and elemental analyses. The mercaptotriazoles are indicated to be in thione form by (1)H NMR spectra. All the synthesized compounds have been screened for antibacterial and antifungal activities. Compounds 12d and 12h exhibit encouraging results, while the remaining compounds show moderate activities. On the basis of spectral studies, formation of 2-amino-1,3,4-thiadiazoles from the isobenzofuran acyl thiosemicarbazides 11(a-h) is ruled out.

  13. 7 CFR 1794.52 - Scoping meetings.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Scoping meetings. 1794.52 Section 1794.52 Agriculture....52 Scoping meetings. (a) Both RUS and the applicant shall have a notice published which announces a public scoping meeting is to be conducted, either in conjunction with the notice of intent or as...

  14. Scope: The Environmental Voice of World Science

    Science.gov (United States)

    Munn, R. E.; Cain, Melinda

    1977-01-01

    SCOPE is an international group that studies the effects of human activities on the environment and serves as a source of advice on environmental problems. Presently, SCOPE is involved with seven major projects that include biogeochemical cycles, ecotoxicology, and environmental monitoring. The structure and components of SCOPE are also discussed.…

  15. 36 CFR 223.130 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Scope. 223.130 Section 223... NATIONAL FOREST SYSTEM TIMBER Suspension and Debarment of Timber Purchasers § 223.130 Scope. (a) This... causes and procedures for debarment and suspension and for determining the scope, duration, and...

  16. 25 CFR 501.2 - Scope.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Scope. 501.2 Section 501.2 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS PURPOSE AND SCOPE OF THIS CHAPTER § 501.2 Scope. (a) Tribes and other operators of class II and class III gaming operations on Indian lands shall...

  17. 36 CFR 251.50 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Scope. 251.50 Section 251.50... § 251.50 Scope. (a) All uses of National Forest System lands, improvements, and resources, except those... routine operation or maintenance activity within the scope of a statutory right-of-way for a...

  18. 40 CFR 1508.25 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Scope. 1508.25 Section 1508.25 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.25 Scope. Scope... same impact statement. It should do so when the best way to assess adequately the combined impacts of...

  19. Making Patent Scopes Exceed the Technological Scopes of Scientific Inventions

    DEFF Research Database (Denmark)

    Beukel, Karin

    This paper presents the results of a grounded theory study of the transformation of scientific discoveries into patented inventions. Using an algebraic interpretive approach, the narratives collected during interviews are analyzed as Bayesian inferences and the developed theory is tested....... The findings recast the relationship between science and patents as a process in which the way the transformation of the scientific invention is handled has an effect on the breadth of the patent scope. Unleashing patent scope surplus is dependent on processes related to abstraction and cognitive variety......, which can be mobilized by patent experts with both an in-depth understanding of the scientific discovery, due to their educational background in the life sciences, and capabilities within the legal framework for patenting. More specifically, the findings reveal previously unreported aspects...

  20. Novel 1,5-diphenylpyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: lead identification and SAR of 3- and 4-substituted derivatives.

    Science.gov (United States)

    Genin, M J; Biles, C; Keiser, B J; Poppe, S M; Swaney, S M; Tarpley, W G; Yagi, Y; Romero, D L

    2000-03-09

    Through computationally directed broad screening, a novel 1, 5-diphenylpyrazole (DPP) class of HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) has been discovered. Compound 2 (PNU-32945) was found to have good activity versus wild-type (IC(50) = 2.3 microM) and delavirdine-resistant P236L (IC(50) = 1.1 microM) reverse transcriptase (RT). Also, PNU-32945 has an ED(50) for inhibition of viral replication in cell cultures of 0.1 microM and was shown to be noncytotoxic with a CC(50) > 10 microM. Structure-activity relationship studies on the 3- and 4-positions of PNU-32945 led to interesting selectivity and activity within the class. In particular, the 3-hydroxyethyl-4-ethyl congener 29 is a potent inhibitor of the P236L mutant (IC(50) = 0.65 microM), whereas it is essentially inactive versus the wild-type enzyme (IC(50) > 50 microM). Furthermore, this compound was significantly more active versus the P236L mutant than delavirdine. The synthesis and RT inhibitory activity of various 3- and 4-substituted analogues are discussed.

  1. Structure-property relationship of 3-(4-substituted benzyl)-1,3-diazaspiro[4.4]nonane-2,4-diones as new potentional anticonvulsant agents. An experimental and theoretical study

    Science.gov (United States)

    Lazić, Anita M.; Božić, Bojan Đ.; Vitnik, Vesna D.; Vitnik, Željko J.; Rogan, Jelena R.; Radovanović, Lidija D.; Valentić, Nataša V.; Ušćumlić, Gordana S.

    2017-01-01

    The structure-property relationship of newly synthesized 3-(4-substituted benzyl)-1,3-diazaspiro [4.4]nonane-2,4-diones was studied by experimental and calculated methods. The prepared compounds were characterized by UV-Vis, FT-IR, 1H NMR and 13C NMR spectroscopy and elemental analysis. The crystal structure was elucidated by single-crystal X-ray diffraction. The 3-benzyl-1,3-diazaspiro[4.4]nonane-2,4-dione crystallizes in triclinic P-1 space group, with two crystallographically independent molecules in the asymmetric unit. Cyclopentane ring adopts an envelope conformation. A three-dimensional crystal packing is governed by hydrogen N-H⋯O bonds, numerous C-H⋯O/N and C-H … π interactions between neighboring molecules. Density functional theory (DFT) calculations with B3LYP and M06-2X methods using 6-311++G(d,p) basis set were performed to provide structural and spectroscopic information. Comparisons between experimental and calculated UV-Vis spectral properties suggest that the monomeric form of the investigated spirohydantoins is dominant in all used solvents. The effects of substituents on the absorption spectra of spirohydantoins are interpreted by correlation of absorption frequencies with Hammett equation. The lipophilicities of the investigated molecules were estimated by calculation of their log P values. Some of the spirohydantoins synthesized in this work, exhibit the lipophilicities comparable to the standard medicine anticonvulsant drug Phenytoin. The results obtained in this investigation afford guidelines for the preparation of new derivatives of spirohydantoin as potential anticonvulsant agents and for better understanding the structure-activity relationship.

  2. Anticonvulsant Profiles of Certain New 6-Aryl-9-substituted-6,9-diazaspiro-[4.5]decane-8,10-diones and 1-Aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones

    Science.gov (United States)

    Aboul-Enein, Mohamed N.; El-Azzouny, Aida A.; Attia, Mohamed I.; Maklad, Yousreya A.; Aboutabl, Mona E.; Ragab, Fatma; El-Hamid, Walaa H. A. Abd

    2014-01-01

    Synthesis and anticonvulsant potential of certain new 6-aryl-9-substituted-6,9-diazaspiro[4.5]decane-8,10-diones (6a–l) and 1-aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones (6m–x) are reported. The intermediates 1-[(aryl)(cyanomethyl)amino]cycloalkanecarboxamides (3a–f) were prepared via adopting Strecker synthesis on the proper cycloalkanone followed by partial hydrolysis of the obtained nitrile functionality and subsequent N-cyanomethylation. Compounds 3a–f were subjected to complete nitrile hydrolysis to give the respective carboxylic acid derivatives 4a–f which were cyclized under mild conditions to give the spiro compounds 5a–f. Ultimately, compounds 5a–f were alkylated or aralkylated to give the target compounds 6a–i and 6m–u. On the other hand, compounds 6j–l and 6v–x were synthesized from the intermediates 5a–f through alkylation, dehydration and finally tetrazole ring formation. Anticonvulsant screening of the target compounds 6a–x revealed that compound 6g showed an ED50 of 0.0043 mmol/kg in the scPTZ screen, being about 14 and 214 fold more potent than the reference drugs, Phenobarbital (ED50 = 0.06 mmol/kg) and Ethosuximide (ED50 = 0.92 mmol/kg), respectively. Compound 6e exhibited an ED50 of 0.019 mmol/kg, being about 1.8 fold more potent than that of the reference drug, Diphenylhydantoin (ED50 = 0.034 mmol/kg) in the MES screen. Interestingly, all the test compounds 6a–x did not show any minimal motor impairment at the maximum administered dose in the neurotoxicity screen. PMID:25250910

  3. Anticonvulsant Profiles of Certain New 6-Aryl-9-substituted-6,9-diazaspiro-[4.5]decane-8,10-diones and 1-Aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones

    Directory of Open Access Journals (Sweden)

    Mohamed N. Aboul-Enein

    2014-09-01

    Full Text Available Synthesis and anticonvulsant potential of certain new 6-aryl-9-substituted-6,9-diazaspiro[4.5]decane-8,10-diones (6a–l and 1-aryl-4-substituted-1,4-diazaspiro[5.5] undecane-3,5-diones (6m–x are reported. The intermediates 1-[(aryl(cyanomethylamino] cycloalkanecarboxamides (3a–f were prepared via adopting Strecker synthesis on the proper cycloalkanone followed by partial hydrolysis of the obtained nitrile functionality and subsequent N-cyanomethylation. Compounds 3a–f were subjected to complete nitrile hydrolysis to give the respective carboxylic acid derivatives 4a–f which were cyclized under mild conditions to give the spiro compounds 5a–f. Ultimately, compounds 5a–f were alkylated or aralkylated to give the target compounds 6a–i and 6m–u. On the other hand, compounds 6j–l and 6v–x were synthesized from the intermediates 5a–f through alkylation, dehydration and finally tetrazole ring formation. Anticonvulsant screening of the target compounds 6a–x revealed that compound 6g showed an ED50 of 0.0043 mmol/kg in the scPTZ screen, being about 14 and 214 fold more potent than the reference drugs, Phenobarbital (ED50 = 0.06 mmol/kg and Ethosuximide (ED50 = 0.92 mmol/kg, respectively. Compound 6e exhibited an ED50 of 0.019 mmol/kg, being about 1.8 fold more potent than that of the reference drug, Diphenylhydantoin (ED50 = 0.034 mmol/kg in the MES screen. Interestingly, all the test compounds 6a–x did not show any minimal motor impairment at the maximum administered dose in the neurotoxicity screen.

  4. IDC Reengineering Phase 2 Project Scope.

    Energy Technology Data Exchange (ETDEWEB)

    Harris, James M.

    2015-02-01

    This report provides a brief description of the scope of the IDC Reengineering Phase 2 project. It describes the goals and objectives of reengineering, the system definition, and the technical scope of the system. REVISIONS Version Date Author/Team Revision Description Authorized by 1.0 9/25/2014 SNL IDC Reengineering Team Unlimited Release for I2 M. Harris 1.1 28/01/2015 IDC Reengineering Team Align with previous IDC scope document E. Tomuta

  5. 77 FR 63309 - Constitution Pipeline Company, LLC; Notice of Public Scoping Meeting and Extension of Scoping...

    Science.gov (United States)

    2012-10-16

    ... Energy Regulatory Commission Constitution Pipeline Company, LLC; Notice of Public Scoping Meeting and Extension of Scoping Period for the Planned Constitution Pipeline Project On October 24, 2012, the Federal... Constitution Pipeline Company's (Constitution) Constitution Pipeline Project. This notice also extends...

  6. A Scoping Review of Scoping Reviews: Advancing the Approach and Enhancing the Consistency

    Science.gov (United States)

    Pham, Mai T.; Rajic, Andrijana; Greig, Judy D.; Sargeant, Jan M.; Papadopoulos, Andrew; McEwen, Scott A.

    2014-01-01

    Background: The scoping review has become an increasingly popular approach for synthesizing research evidence. It is a relatively new approach for which a universal study definition or definitive procedure has not been established. The purpose of this scoping review was to provide an overview of scoping reviews in the literature. Methods: A…

  7. 12 CFR 19.241 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Scope. 19.241 Section 19.241 Banks and Banking..., and Debarment of Accountants From Performing Audit Services § 19.241 Scope. This subpart, which... their accounting firms from performing independent audit and attestation services required by section...

  8. 24 CFR 58.56 - Scoping process.

    Science.gov (United States)

    2010-04-01

    ... Process: Procedures for Draft, Final and Supplemental Environmental Impact Statements § 58.56 Scoping... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Scoping process. 58.56 Section 58.56 Housing and Urban Development Office of the Secretary, Department of Housing and Urban...

  9. 41 CFR 60-3.2 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Scope. 60-3.2 Section 60-3.2 Public Contracts and Property Management Other Provisions Relating to Public Contracts OFFICE OF... GUIDELINES ON EMPLOYEE SELECTION PROCEDURES (1978) General Principles § 60-3.2 Scope. A. Application...

  10. 12 CFR 700.1 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Scope. 700.1 Section 700.1 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS DEFINITIONS § 700.1 Scope. The definitions in § 700.2 apply to terms used in this chapter. Many additional definitions appear in the...

  11. 12 CFR 725.1 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Scope. 725.1 Section 725.1 Banks and Banking... ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.1 Scope. This part contains the regulations implementing the National Credit Union Central Liquidity Facility Act, subchapter III of the Federal Credit Union Act....

  12. 45 CFR 12.2 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Scope. 12.2 Section 12.2 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION DISPOSAL AND UTILIZATION OF SURPLUS REAL PROPERTY FOR PUBLIC HEALTH PURPOSES § 12.2 Scope. This part is applicable to surplus real property located within any State which is appropriate...

  13. Special Education in Indonesia (Scope and Development).

    Science.gov (United States)

    Semiawan, Conny

    The paper covers characteristics of Indonesia's special education program. Considered are the scope of special education, some viewpoints on the impact of culture on the perspective of special education in Indonesia (including programs, services, teacher training, and financial resources). The scope of special education is considered; and some…

  14. 21 CFR 1010.1 - Scope.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Scope. 1010.1 Section 1010.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) RADIOLOGICAL HEALTH PERFORMANCE STANDARDS FOR ELECTRONIC PRODUCTS: GENERAL General Provisions § 1010.1 Scope. The standards...

  15. 44 CFR 351.2 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Scope. 351.2 Section 351.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS RADIOLOGICAL EMERGENCY PLANNING AND PREPAREDNESS General § 351.2 Scope. The emergency planning...

  16. 12 CFR 7.5000 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Scope. 7.5000 Section 7.5000 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY BANK ACTIVITIES AND OPERATIONS Electronic Activities § 7.5000 Scope. This subpart applies to a national bank's use of technology to deliver services and...

  17. Common Cause Abduction : Its Scope and Limits

    NARCIS (Netherlands)

    Dziurosz-Serafinowicz, Patryk

    2012-01-01

    Patryk Dziurosz-Serafmowicz, Common Cause Abduction: Its Scope and Limits This article aims to analyze the scope and limits of common cause abduction which is a version of explanatory abduction based on Hans Reichenbach's Principle of the Common Cause. First, it is argued that common cause abduction

  18. 20 CFR 902.1 - Scope.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Scope. 902.1 Section 902.1 Employees' Benefits JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES RULES REGARDING AVAILABILITY OF INFORMATION § 902.1 Scope. This part is issued by the Joint Board for the Enrollment of Actuaries (the “Joint...

  19. 49 CFR 536.1 - Scope.

    Science.gov (United States)

    2010-10-01

    ... OF TRANSPORTATION TRANSFER AND TRADING OF FUEL ECONOMY CREDITS § 536.1 Scope. This part establishes... manufacturers wishing to transfer fuel economy credits between their fleets and for manufacturers and other... 49 Transportation 6 2010-10-01 2010-10-01 false Scope. 536.1 Section 536.1 Transportation...

  20. 21 CFR 860.1 - Scope.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Scope. 860.1 Section 860.1 Food and Drugs FOOD AND... CLASSIFICATION PROCEDURES General § 860.1 Scope. (a) This part implements sections 513, 514(b), 515(b), and 520(l) of the act with respect to the classification and reclassification of devices intended for human...

  1. 31 CFR 103.80 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Scope. 103.80 Section 103.80 Money and Finance: Treasury Regulations Relating to Money and Finance FINANCIAL RECORDKEEPING AND REPORTING OF CURRENCY AND FOREIGN TRANSACTIONS Administrative Rulings § 103.80 Scope. This subpart...

  2. Anger perceptually and conceptually narrows cognitive scope.

    Science.gov (United States)

    Gable, Philip A; Poole, Bryan D; Harmon-Jones, Eddie

    2015-07-01

    For the last 50 years, research investigating the effect of emotions on scope of cognitive processing was based on models proposing that affective valence determined cognitive scope. More recently, our motivational intensity model suggests that this past work had confounded valence with motivational intensity. Research derived from this model supports the idea that motivational intensity, rather than affective valence, explains much of the variance emotions have on cognitive scope. However, the motivational intensity model is limited in that the empirical work has examined only positive affects high in approach and negative affects high in avoidance motivation. Thus, perhaps only approach-positive and avoidance-negative states narrow cognitive scope. The present research was designed to clarify these conceptual issues by examining the effect of anger, a negatively valenced approach-motivated state, on cognitive scope. Results revealed that anger narrowed attentional scope relative to a neutral state and that attentional narrowing to anger was similar to the attentional narrowing caused by high approach-motivated positive affects (Study 1). This narrowing of attention was related to trait approach motivation (Studies 2 and Study 3). Anger also narrowed conceptual cognitive categorization (Study 4). Narrowing of categorization related to participants' approach motivation toward anger stimuli. Together, these results suggest that anger, an approach-motivated negative affect, narrows perceptual and conceptual cognitive scope. More broadly, these results support the conceptual model that motivational intensity per se, rather than approach-positive and avoidance-negative states, causes a narrowing of cognitive scope.

  3. 10 CFR 76.2 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Scope. 76.2 Section 76.2 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.2 Scope. The regulations in this part apply only to those portions of the Portsmouth and Paducah Gaseous Diffusion...

  4. 47 CFR 90.460 - Scope.

    Science.gov (United States)

    2010-10-01

    ... SERVICES Transmitter Control § 90.460 Scope. This subpart sets forth the provisions relating to permissible methods of transmitter control and interconnection (see the definition in § 90.7) of radio systems... 47 Telecommunication 5 2010-10-01 2010-10-01 false Scope. 90.460 Section 90.460 Telecommunication...

  5. 14 CFR 1203b.101 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Scope. 1203b.101 Section 1203b.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SECURITY PROGRAMS; ARREST AUTHORITY AND USE OF FORCE BY NASA SECURITY FORCE PERSONNEL § 1203b.101 Scope. This part applies to only those...

  6. 5 CFR 831.1101 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Scope. 831.1101 Section 831.1101 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Prohibition on Payments of Annuities § 831.1101 Scope. This subpart prescribes the procedures to be followed in determining whether...

  7. 16 CFR 1101.2. - Scope.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Scope. 1101.2. Section 1101.2. Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INFORMATION DISCLOSURE UNDER SECTION 6(b) OF THE CONSUMER PRODUCT SAFETY ACT Background § 1101.2. Scope. Section 6(b) and these rules apply to information...

  8. 19 CFR 134.0 - Scope.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 134.0 Section 134.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING § 134.0 Scope. This part sets forth regulations implementing the country of origin...

  9. 49 CFR 192.501 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 192.501 Section 192.501 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Test Requirements § 192.501 Scope. This...

  10. 40 CFR 142.3 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Scope. 142.3 Section 142.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS IMPLEMENTATION General Provisions § 142.3 Scope. (a) Except...

  11. 42 CFR 423.150 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 423.150 Section 423.150 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE... § 423.150 Scope. This subpart sets forth the requirements relating to the following: (a)...

  12. 28 CFR 90.60 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Scope. 90.60 Section 90.60 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) VIOLENCE AGAINST WOMEN Arrest Policies in Domestic Violence Cases § 90.60 Scope. This subpart sets forth the statutory framework of the Violence Against Women...

  13. 40 CFR 81.11 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Scope. 81.11 Section 81.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) DESIGNATION OF AREAS FOR AIR QUALITY PLANNING PURPOSES Designation of Air Quality Control Regions § 81.11 Scope....

  14. 32 CFR 726.2 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Scope. 726.2 Section 726.2 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL PAYMENTS OF AMOUNTS DUE MENTALLY INCOMPETENT MEMBERS OF THE NAVAL SERVICE § 726.2 Scope. (a) The Secretary of the Navy has authority...

  15. 28 CFR 92.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Scope. 92.1 Section 92.1 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) OFFICE OF COMMUNITY ORIENTED POLICING SERVICES (COPS) Police Corps Eligibility and Selection Criteria § 92.1 Scope. This subpart sets forth guidance on...

  16. 49 CFR 191.1 - Scope.

    Science.gov (United States)

    2010-10-01

    ..., operation, and maintenance under 49 CFR 190.9. (3) Pipelines on the Outer Continental Shelf upstream of the... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 191.1 Section 191.1 Transportation Other...; ANNUAL REPORTS, INCIDENT REPORTS, AND SAFETY-RELATED CONDITION REPORTS § 191.1 Scope. (a) This...

  17. 40 CFR 79.30 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Scope. 79.30 Section 79.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGISTRATION OF FUELS AND FUEL ADDITIVES Designation of Fuels and Additives § 79.30 Scope. Fuels and...

  18. 49 CFR 190.301 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 190.301 Section 190.301 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PROCEDURES Procedures for Adoption of Rules § 190.301 Scope. This subpart prescribes general...

  19. 42 CFR 424.60 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 424.60 Section 424.60 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM CONDITIONS FOR MEDICARE PAYMENT To Whom Payment is Made in Special Situations § 424.60 Scope. (a)...

  20. 48 CFR 939.7000 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Scope. 939.7000 Section 939.7000 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Implementing DOE Policies and Procedures 939.7000 Scope. This part...

  1. 32 CFR 761.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Scope. 761.1 Section 761.1 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY ISLANDS UNDER NAVY JURISDICTION NAVAL DEFENSIVE SEA... PACIFIC ISLANDS Introduction § 761.1 Scope. (a) This part provides regulations governing the entry...

  2. 42 CFR 423.1968 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 423.1968 Section 423.1968 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE... Review § 423.1968 Scope. This subpart sets forth the requirements relating to the following: (a) Part...

  3. 36 CFR 261.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Scope. 261.1 Section 261.1 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS General Prohibitions § 261.1 Scope. (a) The prohibitions in this part apply, except as otherwise provided, when: (1)...

  4. 42 CFR 424.100 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 424.100 Section 424.100 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE... Nonparticipating Hospital § 424.100 Scope. This subpart sets forth procedures and criteria that are followed...

  5. 49 CFR 192.51 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 192.51 Section 192.51 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION...: MINIMUM FEDERAL SAFETY STANDARDS Materials § 192.51 Scope. This subpart prescribes minimum...

  6. 49 CFR 193.2051 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 193.2051 Section 193.2051 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY...: FEDERAL SAFETY STANDARDS Siting Requirements § 193.2051 Scope. Each LNG facility designed,...

  7. 49 CFR 192.101 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 192.101 Section 192.101 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Pipe Design § 192.101 Scope. This subpart...

  8. 49 CFR 195.48 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.48 Section 195.48 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION... Annual, Accident, and Safety-Related Condition Reporting § 195.48 Scope. This subpart...

  9. 40 CFR 80.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Scope. 80.1 Section 80.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES General Provisions § 80.1 Scope. (a) This part prescribes regulations for the control...

  10. 42 CFR 415.100 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 415.100 Section 415.100 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE... § 415.100 Scope. This subpart implements section 1887(a)(1)(A) of the Act by providing...

  11. 42 CFR 424.120 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 424.120 Section 424.120 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE....120 Scope. This subpart sets forth the conditions for payment for services furnished in a...

  12. 49 CFR 195.100 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.100 Section 195.100 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.100 Scope. This subpart prescribes minimum design requirements for...

  13. 42 CFR 415.150 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 415.150 Section 415.150 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE... RESIDENTS IN CERTAIN SETTINGS Physician Services in Teaching Settings § 415.150 Scope. This subpart...

  14. 49 CFR 195.300 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.300 Section 195.300 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Pressure Testing § 195.300 Scope. This subpart prescribes minimum requirements for the...

  15. 49 CFR 192.271 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 192.271 Section 192.271 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... Scope. (a) This subpart prescribes minimum requirements for joining materials in pipelines, other...

  16. 49 CFR 193.2701 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 193.2701 Section 193.2701 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY...: FEDERAL SAFETY STANDARDS Personnel Qualifications and Training § 193.2701 Scope. This subpart...

  17. 32 CFR 756.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Scope. 756.1 Section 756.1 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY CLAIMS PROCEDURES FOR PROCESSING CLAIMS INVOLVING NON-APPROPRIATED FUND ACTIVITIES AND THEIR EMPLOYEES § 756.1 Scope. This part explains how to...

  18. 49 CFR 195.200 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.200 Section 195.200 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.200 Scope. This subpart prescribes minimum requirements for constructing...

  19. 42 CFR 423.251 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 423.251 Section 423.251 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE...; Plan Approval § 423.251 Scope. This section sets forth the requirements and limitations on...

  20. 42 CFR 423.301 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 423.301 Section 423.301 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE... Prescription Drug Coverage § 423.301 Scope. This subpart sets forth rules for the calculation and payment...

  1. 36 CFR 228.2 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Scope. 228.2 Section 228.2 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE MINERALS Locatable Minerals § 228.2 Scope. These regulations apply to operations hereafter conducted under the United...

  2. 42 CFR 424.500 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 424.500 Section 424.500 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE... Privileges § 424.500 Scope. The provisions of this subpart contain the requirements for enrollment,...

  3. 32 CFR 734.2 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Scope. 734.2 Section 734.2 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL GARNISHMENT OF PAY OF NAVAL MILITARY AND CIVILIAN PERSONNEL FOR COLLECTION OF CHILD SUPPORT AND ALIMONY § 734.2 Scope. The provisions of this...

  4. 40 CFR 172.20 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Scope. 172.20 Section 172.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS EXPERIMENTAL USE PERMITS State Issuance of Experimental Use Permits § 172.20 Scope. This subpart sets forth...

  5. 32 CFR 755.2 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Scope. 755.2 Section 755.2 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY CLAIMS CLAIMS FOR INJURIES TO PROPERTY UNDER ARTICLE 139 OF THE UNIFORM CODE OF MILITARY JUSTICE § 755.2 Scope. This chapter provides for...

  6. 32 CFR 752.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Scope. 752.1 Section 752.1 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY CLAIMS ADMIRALTY CLAIMS § 752.1 Scope. This part applies to admiralty-tort claims. These include claims against the United States for damage caused by...

  7. 40 CFR 152.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Scope. 152.1 Section 152.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE REGISTRATION AND CLASSIFICATION PROCEDURES General Provisions § 152.1 Scope. (a) Part 152 sets forth...

  8. 49 CFR 199.1 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 199.1 Section 199.1 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY DRUG AND ALCOHOL TESTING General § 199.1 Scope....

  9. 49 CFR 193.2901 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 193.2901 Section 193.2901 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY...: FEDERAL SAFETY STANDARDS Security § 193.2901 Scope. This subpart prescribes requirements for security...

  10. 49 CFR 192.551 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 192.551 Section 192.551 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Uprating § 192.551 Scope. This subpart...

  11. 40 CFR 165.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Scope. 165.1 Section 165.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE MANAGEMENT AND DISPOSAL General § 165.1 Scope. The part 165 regulations establish standards and requirements...

  12. 40 CFR 152.100 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Scope. 152.100 Section 152.100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE REGISTRATION AND CLASSIFICATION PROCEDURES Agency Review of Applications § 152.100 Scope. (a) The Agency...

  13. 40 CFR 88.201-94 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Scope. 88.201-94 Section 88.201-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES California Pilot Test Program § 88.201-94 Scope. Applicability. The requirements of this...

  14. 40 CFR 180.2000 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Scope. 180.2000 Section 180.2000 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND... Exemption From a Tolerance § 180.2000 Scope. This subpart sets forth the pesticide chemicals for use...

  15. 31 CFR 1.8 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Scope. 1.8 Section 1.8 Money and Finance: Treasury Office of the Secretary of the Treasury DISCLOSURE OF RECORDS Other Disclosure Provisions § 1.8 Scope. The regulations in this subpart concern access to information and records other...

  16. 49 CFR 1151.1 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Scope. 1151.1 Section 1151.1 Transportation Other Regulations Relating to Transportation (Continued) SURFACE TRANSPORTATION BOARD, DEPARTMENT OF TRANSPORTATION RULES OF PRACTICE FEEDER RAILROAD DEVELOPMENT PROGRAM § 1151.1 Scope. This part governs...

  17. 42 CFR 424.50 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 424.50 Section 424.50 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM CONDITIONS FOR MEDICARE PAYMENT To Whom Payment Is Ordinarily Made § 424.50 Scope. (a) This subpart...

  18. 40 CFR 152.160 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Scope. 152.160 Section 152.160 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE REGISTRATION AND CLASSIFICATION PROCEDURES Classification of Pesticides § 152.160 Scope. (a) Types...

  19. 42 CFR 423.500 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 423.500 Section 423.500 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE... sponsors § 423.500 Scope. This subpart sets forth application procedures and contracts with Part D...

  20. 49 CFR 377.201 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Scope. 377.201 Section 377.201 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION... Forwarders § 377.201 Scope. (a) General. These regulations apply to the extension of credit in...

  1. 49 CFR 195.501 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.501 Section 195.501 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Qualification of Pipeline Personnel § 195.501 Scope. (a) This subpart prescribes the...

  2. 49 CFR 192.351 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 192.351 Section 192.351 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... § 192.351 Scope. This subpart prescribes minimum requirements for installing customer meters,...

  3. 31 CFR 8.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Scope. 8.1 Section 8.1 Money and Finance: Treasury Office of the Secretary of the Treasury PRACTICE BEFORE THE BUREAU OF ALCOHOL, TOBACCO AND FIREARMS General Requirements § 8.1 Scope. This part contains rules governing the recognition...

  4. 49 CFR 192.221 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 192.221 Section 192.221 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Welding of Steel in Pipelines § 192.221 Scope. (a)...

  5. 49 CFR 1118.1 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Scope. 1118.1 Section 1118.1 Transportation Other Regulations Relating to Transportation (Continued) SURFACE TRANSPORTATION BOARD, DEPARTMENT OF TRANSPORTATION RULES OF PRACTICE PROCEDURES IN INFORMAL PROCEEDINGS BEFORE EMPLOYEE BOARDS § 1118.1 Scope. The rules...

  6. 49 CFR 198.31 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 198.31 Section 198.31 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION... PROGRAMS Adoption of One-Call Damage Prevention Program § 198.31 Scope. This subpart implements parts...

  7. 40 CFR 81.400 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Scope. 81.400 Section 81.400 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) DESIGNATION OF... Visibility Is an Important Value § 81.400 Scope. Subpart D, §§ 81.401 through 81.437, lists those...

  8. 49 CFR 195.400 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.400 Section 195.400 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Operation and Maintenance § 195.400 Scope. This subpart prescribes minimum requirements...

  9. 49 CFR 192.301 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 192.301 Section 192.301 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... Lines and Mains § 192.301 Scope. This subpart prescribes minimum requirements for...

  10. 49 CFR 192.451 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 192.451 Section 192.451 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Requirements for Corrosion Control § 192.451 Scope....

  11. 42 CFR 423.851 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 423.851 Section 423.851 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE... Prescription Drug Plans) § 423.851 Scope. This subpart sets forth—the rights of beneficiaries to a choice of...

  12. 49 CFR 198.1 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 198.1 Section 198.1 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION... PROGRAMS General § 198.1 Scope. This part prescribes regulations governing grants-in-aid for State...

  13. 49 CFR 1121.1 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Scope. 1121.1 Section 1121.1 Transportation Other Regulations Relating to Transportation (Continued) SURFACE TRANSPORTATION BOARD, DEPARTMENT OF TRANSPORTATION RULES OF PRACTICE RAIL EXEMPTION PROCEDURES § 1121.1 Scope. These procedures generally govern...

  14. 25 CFR 571.1 - Scope.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Scope. 571.1 Section 571.1 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR COMPLIANCE AND ENFORCEMENT PROVISIONS MONITORING AND INVESTIGATIONS General § 571.1 Scope. This part sets forth general procedures governing Commission monitoring...

  15. 32 CFR 751.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Scope. 751.1 Section 751.1 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY CLAIMS PERSONNEL CLAIMS REGULATIONS Claims Against the United States § 751.1 Scope. This part prescribes procedures and substantive bases...

  16. 49 CFR 192.801 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 192.801 Section 192.801 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Qualification of Pipeline Personnel § 192.801 Scope....

  17. 31 CFR 15.737-1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Scope. 15.737-1 Section 15.737-1 Money and Finance: Treasury Office of the Secretary of the Treasury POST EMPLOYMENT CONFLICT OF INTEREST General Provisions § 15.737-1 Scope. This part contains rules governing discipline of a former officer...

  18. 42 CFR 424.30 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 424.30 Section 424.30 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM CONDITIONS FOR MEDICARE PAYMENT Claims for Payment § 424.30 Scope. This subpart sets forth the...

  19. 49 CFR 195.0 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.0 Section 195.0 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION... General § 195.0 Scope. This part prescribes safety standards and reporting requirements for...

  20. 49 CFR 192.601 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 192.601 Section 192.601 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Operations § 192.601 Scope. This subpart...

  1. 42 CFR 423.558 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 423.558 Section 423.558 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE..., and Reconsiderations § 423.558 Scope. (a) This subpart sets forth the requirements relating to...

  2. 49 CFR 396.1 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Scope. 396.1 Section 396.1 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS INSPECTION, REPAIR, AND MAINTENANCE § 396.1 Scope....

  3. 42 CFR 423.452 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 423.452 Section 423.452 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE... Drug Coverage § 423.452 Scope. This section sets forth the application of Part D rules to Part C...

  4. 28 CFR 92.7 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Scope. 92.7 Section 92.7 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) OFFICE OF COMMUNITY ORIENTED POLICING SERVICES (COPS) Police Recruitment Program Guidelines § 92.7 Scope. (a) The Police Recruitment program offers funds to...

  5. 49 CFR 192.141 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 192.141 Section 192.141 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of Pipeline Components § 192.141 Scope....

  6. 49 CFR 192.701 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 192.701 Section 192.701 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Maintenance § 192.701 Scope. This subpart...

  7. 49 CFR 1120.1 - Scope.

    Science.gov (United States)

    2010-10-01

    ... accounting instruction number 27 of the Board's Uniform System of Accounts (49 CFR Part 1207). ... 49 Transportation 8 2010-10-01 2010-10-01 false Scope. 1120.1 Section 1120.1 Transportation Other... RULES OF PRACTICE USE OF 1977-1978 STUDY OF MOTOR CARRIER PLATFORM HANDLING FACTORS § 1120.1 Scope....

  8. 48 CFR 970.1707-1 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Scope. 970.1707-1 Section 970.1707-1 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Special Contracting Methods 970.1707-1 Scope. Pursuant...

  9. 42 CFR 417.140 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Scope. 417.140 Section 417.140 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE... Application for Federal Qualification § 417.140 Scope. This subpart sets forth— (a) The requirements for—...

  10. 49 CFR 193.2601 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 193.2601 Section 193.2601 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY...: FEDERAL SAFETY STANDARDS Maintenance § 193.2601 Scope. This subpart prescribes requirements...

  11. 30 CFR 828.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Scope. 828.1 Section 828.1 Mineral Resources... PERFORMANCE STANDARDS SPECIAL PERMANENT PROGRAM PERFORMANCE STANDARDS-IN SITU PROCESSING § 828.1 Scope. This... situ processing activities....

  12. 21 CFR 866.1 - Scope.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Scope. 866.1 Section 866.1 Food and Drugs FOOD AND... MICROBIOLOGY DEVICES General Provisions § 866.1 Scope. (a) This part sets forth the classification of immunology and microbiology devices intended for human use that are in commercial distribution. (b)...

  13. Special Education in Indonesia (Scope and Development).

    Science.gov (United States)

    Semiawan, Conny

    The paper covers characteristics of Indonesia's special education program. Considered are the scope of special education, some viewpoints on the impact of culture on the perspective of special education in Indonesia (including programs, services, teacher training, and financial resources). The scope of special education is considered; and some…

  14. 18 CFR 1b.2 - Scope.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Scope. 1b.2 Section 1b.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.2 Scope. This part applies to...

  15. 10 CFR 850.1 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Scope. 850.1 Section 850.1 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM General Provisions § 850.1 Scope. This part provides for establishment of a chronic beryllium disease prevention program (CBDPP) that supplements and is deemed...

  16. 77 FR 52313 - Notice of Scope Rulings

    Science.gov (United States)

    2012-08-29

    ... rulings, the Department indicated it had completed the scope review of magnesia carbon bricks from Mexico...-910/C-570-911: Circular Welded Carbon Quality Steel Pipe from the People's Republic of China Requestor... ruling, finding Fedmet's magnesia alumina carbon bricks within the scope of the antidumping...

  17. 14 CFR 1221.100 - Scope.

    Science.gov (United States)

    2010-01-01

    ..., and the Agency's Unified Visual Communications System § 1221.100 Scope. This subpart sets forth the... Unified Visual Communications System and prescribes the policy and guidelines for implementation of...

  18. 46 CFR 61.30-1 - Scope.

    Science.gov (United States)

    2010-10-01

    ... Inspections of Fired Thermal Fluid Heaters § 61.30-1 Scope. The term thermal fluid heater as used in this part... °F) and 225 psig, respectively. Thermal fluid heaters having operating temperatures and...

  19. Scope of nanotechnology in modern textiles

    Science.gov (United States)

    This review article demonstrates the scope and applications of nanotechnology towards modification and development of advanced textile fibers, yarns and fabrics and their processing techniques. Basically, it summarizes the recent advances made in nanotechnology and its applications to cotton textil...

  20. 14 CFR 171.101 - Scope.

    Science.gov (United States)

    2010-01-01

    ... FACILITIES NON-FEDERAL NAVIGATION FACILITIES Simplified Directional Facility (SDF) § 171.101 Scope. This... Directional Facilities (SDF) that are to be involved in the approval of instrument flight rules and...

  1. 49 CFR 130.2 - Scope.

    Science.gov (United States)

    2010-10-01

    ... TRANSPORTATION OIL TRANSPORTATION OIL SPILL PREVENTION AND RESPONSE PLANS § 130.2 Scope. (a) The requirements of... 112, appendix A). (d) The requirements in § 130.31(b) of this part do not apply to mobile marine...

  2. 21 CFR 358.301 - Scope.

    Science.gov (United States)

    2010-04-01

    ... MISCELLANEOUS EXTERNAL DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE Ingrown Toenail Relief Drug Products § 358.301 Scope. (a) An over-the-counter ingrown toenail relief drug product in a form suitable for...

  3. 23 CFR 1350.1 - Scope.

    Science.gov (United States)

    2010-04-01

    ... TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INCENTIVE GRANT CRITERIA FOR MOTORCYCLIST SAFETY PROGRAM § 1350.1 Scope. This part establishes criteria, in accordance with section 2010 of the... single- and multi-vehicle crashes involving motorcyclists....

  4. 45 CFR 1000.1 - Scope.

    Science.gov (United States)

    2010-10-01

    ... AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIVIDUAL DEVELOPMENT ACCOUNT RESERVE FUNDS ESTABLISHED PURSUANT TO GRANTS FOR ASSETS FOR INDEPENDENCE § 1000.1 Scope. This part applies to the Office of Community Services' Assets for Independence Program....

  5. 48 CFR 23.1000 - Scope.

    Science.gov (United States)

    2010-10-01

    ... WORKPLACE Federal Compliance With Right-To-Know Laws and Pollution Prevention Requirements 23.1000 Scope...) Compliance with right-to-know laws and pollution prevention requirements; (b) Implementation of...

  6. 49 CFR 215.101 - Scope.

    Science.gov (United States)

    2010-10-01

    ... TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components § 215.101 Scope. This subpart contains safety requirements prohibiting a railroad from placing or continuing in service a freight car that has certain defective components. Suspension System...

  7. 45 CFR 673.2 - Scope.

    Science.gov (United States)

    2010-10-01

    ... of the Antarctic Treaty. ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Scope. 673.2 Section 673.2 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ANTARCTIC...

  8. 75 FR 38081 - Notice of Scope Rulings

    Science.gov (United States)

    2010-07-01

    ... Fold-Away Truck, Relius Tray-Shelf Utility Cart, Economical Steel Cart, Solid Platform Dolly and Flush Platform Dolly are all outside the scope of the antidumping duty order; December 3, 2009. A-570-901:...

  9. 75 FR 14138 - Notice of Scope Rulings

    Science.gov (United States)

    2010-03-24

    ... Truck, Relius Tray-Shelf Utility Cart, Economical Steel Cart, Solid Platform Dolly and Flush Platform Dolly are all outside the scope of the antidumping duty order; December 3, 2009. A-570-899:...

  10. 7 CFR 610.2 - Scope.

    Science.gov (United States)

    2010-01-01

    ... the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE CONSERVATION OPERATIONS TECHNICAL ASSISTANCE Conservation Operations § 610.2 Scope. (a) Conservation operations, including technical assistance, is the basic soil and water conservation program...

  11. 48 CFR 219.7100 - Scope.

    Science.gov (United States)

    2010-10-01

    ... DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Pilot Mentor-Protege Program 219.7100 Scope. This... protege firms in enhancing their capabilities and to increase participation of such firms in...

  12. 12 CFR 303.220 - Scope.

    Science.gov (United States)

    2010-01-01

    ... of the FDI Act (Consent to Service of Persons Convicted of Certain Criminal Offenses) § 303.220 Scope. This subpart covers applications under section 19 of the FDI Act (12 U.S.C. 1829). Pursuant to...

  13. 21 CFR 338.1 - Scope.

    Science.gov (United States)

    2010-04-01

    ... SLEEP-AID DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE General Provisions § 338.1 Scope. (a) An over-the-counter nighttime sleep-aid drug product in a form suitable for oral administration is generally... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Scope. 338.1 Section 338.1 Food and Drugs FOOD AND...

  14. Harry Potter and the sorcerer's scope: latent scope biases in explanatory reasoning.

    Science.gov (United States)

    Khemlani, Sangeet S; Sussman, Abigail B; Oppenheimer, Daniel M

    2011-04-01

    What makes a good explanation? We examine the function of latent scope, i.e., the number of unobserved phenomena that an explanation can account for. We show that individuals prefer narrow latent scope explanations-those that account for fewer unobserved effects-to broader explanations. In Experiments 1a-d, participants found narrow latent scope explanations to be both more satisfying and more likely. In Experiment 2 we directly manipulated base rate information and again found a preference for narrow latent scope explanations. Participants in Experiment 3 evaluated more natural explanations of unexpected observations, and again displayed a bias for narrow latent scope explanations. We conclude by considering what this novel bias tells us about how humans evaluate explanations and engage in causal reasoning.

  15. The ParaScope parallel programming environment

    Science.gov (United States)

    Cooper, Keith D.; Hall, Mary W.; Hood, Robert T.; Kennedy, Ken; Mckinley, Kathryn S.; Mellor-Crummey, John M.; Torczon, Linda; Warren, Scott K.

    1993-01-01

    The ParaScope parallel programming environment, developed to support scientific programming of shared-memory multiprocessors, includes a collection of tools that use global program analysis to help users develop and debug parallel programs. This paper focuses on ParaScope's compilation system, its parallel program editor, and its parallel debugging system. The compilation system extends the traditional single-procedure compiler by providing a mechanism for managing the compilation of complete programs. Thus, ParaScope can support both traditional single-procedure optimization and optimization across procedure boundaries. The ParaScope editor brings both compiler analysis and user expertise to bear on program parallelization. It assists the knowledgeable user by displaying and managing analysis and by providing a variety of interactive program transformations that are effective in exposing parallelism. The debugging system detects and reports timing-dependent errors, called data races, in execution of parallel programs. The system combines static analysis, program instrumentation, and run-time reporting to provide a mechanical system for isolating errors in parallel program executions. Finally, we describe a new project to extend ParaScope to support programming in FORTRAN D, a machine-independent parallel programming language intended for use with both distributed-memory and shared-memory parallel computers.

  16. Psycholinguistic Evidence for Inverse Scope in Korean.

    Science.gov (United States)

    Lee, Sunyoung; O'Grady, William

    2016-08-01

    We use experimental data to shed light on the ongoing question of whether Korean allows inverse scope interpretation in sentences containing an indefinite subject and a universally quantified direct object (e.g., 'Someone bought each loaf of bread at the bakery'). The results of an off-line acceptability judgment task (n = 38) and an online self-paced reading task (n [Formula: see text] 22) indicate that inverse scope interpretations are in fact permitted in Korean as a secondary option, as is also the case in English. We argue that the dispreference for the inverse scope reading reflects processing considerations related to burden on working memory.

  17. 宜丽客 Scope Node

    Institute of Scientific and Technical Information of China (English)

    老未

    2011-01-01

    话说美编卡卡入手了宜丽客(ELECOM)的握笔型镭射鼠Scope Node之后(见2010年最后一期的Gadget),对那玩意可谓是爱不释手,老朱屡次欲把她的爱鼠借来给各位童鞋做个试用报告,均遭到了卡卡无情的拒绝。终于有一天,老朱趁着卡卡吃饱了盖浇饭、趴在桌子上午睡的时候,才偷偷地把Scope Node“借”过来折腾了一番,至此Scope Node之谜才大白于天下。

  18. Scope of practice in renal nutrition.

    Science.gov (United States)

    Byham-Gray, Laura D; Wiesen, Karen; Goode, Jill

    2006-04-01

    Clinical standards for practice in renal nutrition can vary dramatically from region to region, state to state, and clinic to clinic, and are greatly affected by the policies of several governing bodies. This review explores the factors that influence practice patterns among renal dietitians and examines the current American Dietetic Association's Scope of Dietetics Practice Framework for its applicability to kidney disease. Lastly, this article discusses current strategies for establishing a scope of practice in renal nutrition and evaluates licensure and credentialing issues that impact standards for practice across the various regions of the United States.

  19. Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)

    Energy Technology Data Exchange (ETDEWEB)

    Tsoua, Hwei-Ru; MacEwana, Gloria; Birnberga, Gary; Grosua, George; Bursavicha, Matthew G.; Barda, Joel; Brooijmansa, Natasja; Toral-Barzab, Lourdes; Hollanderb, Irwin; Mansoura, Tarek S.; Ayral-Kaloustiana, Semiramis; Yub, Ker (Wyeth)

    2010-07-19

    We discovered 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). Since phenolic OH groups pose metabolic liability, one of the two hydroxyl groups was selectively removed. The SAR data showed the structural features necessary for subnanomolar inhibitory activity against mTOR kinase as well as selectivity over PI3K?. An X-ray co-crystal structure of one inhibitor with the mTOR-related PI3K? revealed the key hydrogen bonding interactions.

  20. SYNTHESIS, CHARACTERIZATION AND BIOCIDAL ACTIVITY OF NOVEL HALOGENATED - 4-[(SUBSTITUTED-BENZOTHIAZOL-2-YL HYDRAZONO]-2-(SUBSTITUTED-PHENYL-5-METHYL /ETHOXY -2,4-DIHYDRO-PYRAZOL-3-ONE DERIVATIVES Synthese, Charakterisierung und biozide Aktivität NOVEL HALOGENIERTEN - 4 - [(substituiertes-benzothiazol-2-YL hydrazono] -2 -(Substituiertes Phenyl-5-Methyl / ETHOXY -2,4-DIHYDRO-pyrazol-3-ONE DERIVATE

    Directory of Open Access Journals (Sweden)

    V. Khatri, K. Sharma, V. Sareen, D. Shinde and S. Sareen

    2012-04-01

    Full Text Available Some new 4-[(substituted-benzothiazol-2-ylhydrazono]-2-(substituted-phenyl-5- methyl/ethoxy-2,4-dihydro-pyrazol-3-one(4 have been synthesized by reacting substituted 2- amino benzothiazol (1 with acetoacetic ester and malonic ester (2. 2-[(substituted-benzothiazol- 2-ylhydrazono]-3-oxo-butyric acid ethyl ester and 2-[(substituted-benzothiazol-2- ylhydrazono]- malonic acid diethyl ester (3 react with different hydrazines to give the title compounds(4. These compounds are evaluated for their antifungal and insecticidal activity. The structures of all these compounds have been confirmed by IR, 1H NMR, mass spectra and elemental analysis data.

  1. 40 CFR 305.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND... (CERCLA) ADMINISTRATIVE HEARING PROCEDURES FOR CLAIMS AGAINST THE SUPERFUND General § 305.1 Scope. (a)(1) This part governs all administrative proceedings for the total or partial denial of response...

  2. 12 CFR 308.600 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Scope. 308.600 Section 308.600 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE RULES OF PRACTICE AND PROCEDURE Removal, Suspension, and Debarment of Accountants From Performing Audit Services § 308.600...

  3. 12 CFR 263.400 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Scope. 263.400 Section 263.400 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES OF PRACTICE FOR HEARINGS Removal, Suspension, and Debarment of Accountants From Performing Audit...

  4. 29 CFR 1450.19 - Scope.

    Science.gov (United States)

    2010-07-01

    ... prohibited by another statute (e.g., travel advances in 5 U.S.C. 5705 and employee training expenses in 5 U.S... STATES Salary Offset § 1450.19 Scope. (a) Coverage. This subpart applies to agencies and employees as... by offset, except where the employee consents to the recovery, from the current pay account of...

  5. 49 CFR 563.1 - Scope.

    Science.gov (United States)

    2010-10-01

    ... OF TRANSPORTATION EVENT DATA RECORDERS § 563.1 Scope. This part specifies uniform, national requirements for vehicles equipped with event data recorders (EDRs) concerning the collection, storage, and retrievability of onboard motor vehicle crash event data. It also specifies requirements for...

  6. 5 CFR 550.371 - Scope.

    Science.gov (United States)

    2010-01-01

    ...) Allotments From Federal Employees Foreign Affairs Agency Organizations § 550.371 Scope. If an agency permits an employee to make an allotment for dues to a foreign affairs agency organization, the agency must... dues withholding agreement between a foreign affairs agency and the organization is terminated or...

  7. 46 CFR 164.013-1 - Scope.

    Science.gov (United States)

    2010-10-01

    ... APPROVAL MATERIALS Foam, Unicellular Polyethylene (Buoyant, Slab, Slitted Trigonal Pattern) § 164.013-1 Scope. (a) This subpart contains performance requirements, acceptance tests, and production testing and inspection requirements for polyethylene foam used in the construction of personal flotation devices (PFDs...

  8. 34 CFR 668.1 - Scope.

    Science.gov (United States)

    2010-07-01

    .... 1087aa et seq.; 34 CFR parts 673 and 674); (11) The National Science and Mathematics Access to Retain... 34 Education 3 2010-07-01 2010-07-01 false Scope. 668.1 Section 668.1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT...

  9. 34 CFR 691.71 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Scope. 691.71 Section 691.71 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION ACADEMIC COMPETITIVENESS GRANT (ACG) AND NATIONAL SCIENCE AND MATHEMATICS ACCESS...

  10. 32 CFR 552.212 - Scope.

    Science.gov (United States)

    2010-07-01

    ... Installation of Aberdeen Proving Ground, Maryland § 552.212 Scope. (a) The provisions of this subpart apply to all elements of U.S. Army Garrison, Aberdeen Proving Ground (USAGAPG), and the supported organizations and activities on the Aberdeen and Edgewood Areas of Aberdeen Proving Ground. (b) The provisions...

  11. 12 CFR 370.1 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Scope. 370.1 Section 370.1 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY TEMPORARY LIQUIDITY..., requirements, and other provisions related to participation in the FDIC's temporary liquidity guarantee program....

  12. 45 CFR 5.3 - Scope.

    Science.gov (United States)

    2010-10-01

    ... § 5.3 Scope. These rules apply to all components of the Department. Some units may establish additional rules because of unique program requirements, but such rules must be consistent with these rules and must have the concurrence of the Assistant Secretary for Public Affairs. Existing...

  13. 40 CFR 300.3 - Scope.

    Science.gov (United States)

    2010-07-01

    ... Introduction § 300.3 Scope. (a) The NCP applies to and is in effect for: (1) Discharges of oil into or on the... and is in effect when the Federal Response Plan and some or all its Emergency Support Functions...

  14. 21 CFR 26.3 - Scope.

    Science.gov (United States)

    2010-04-01

    ... PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS, AND CERTAIN... Provisions for Pharmaceutical Good Manufacturing Practices § 26.3 Scope. (a) The provisions of this subpart... inspections and the good manufacturing practices (GMP's) requirements. (c) Appendix B of this subpart...

  15. 49 CFR 585.11 - Scope.

    Science.gov (United States)

    2010-10-01

    ... OF TRANSPORTATION (CONTINUED) PHASE-IN REPORTING REQUIREMENTS Advanced Air Bag Phase-in Reporting Requirements § 585.11 Scope. This subpart establishes requirements for manufacturers of passenger cars and... air bag requirements of Standard No. 208, Occupant crash protection (49 CFR 571.208). ...

  16. 32 CFR 516.27 - Scope.

    Science.gov (United States)

    2010-07-01

    ... proceeding. Examples of civil actions alleging individual liability include the following: a medical... Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION Individual Liability § 516.27 Scope. This subpart guidance when DA personnel, as a result of...

  17. Scope management in web application projects

    Directory of Open Access Journals (Sweden)

    Cristina Coelho de Abreu Pinna

    2008-07-01

    Full Text Available Software projects are subjected to certain risks and uncertainties, especially those that include Web applications, due to the fact that market competition aims to have electronic and virtual services available in a shorter and shorter period of time (also known as “Internet timing”. Another critical factor relates to the focus to be adopted into the management of Web application projects – should technology or business process be emphasized? This fact produces some difficulties in the acceptance of the software by the customer. This problem could be minimized by appropriate management of the project scope from its earliest phases (conception and planning. The article will present an approach that can be utilized on the management of Web applications projects for the minimization of uncertainties and risks when defining scope. A comparative and critical analysis will be carried out among several instruments and techniques that can be utilized on the definition of scope and priorities such as: QFD, Business Process Modeling and Partitioning. Key-words: Project Management, Scope Management, Web applications, QFD.

  18. Scope Management of Non-Functional Requirements

    NARCIS (Netherlands)

    Kassab, M.; Daneva, M.; Ormandjieva, O.; Mueller, P.; Lyggesmeyer, P.; Maehle, E.

    2007-01-01

    In order to meet commitments in software projects, a realistic assessment must be made of project scope. Such an assessment relies on the availability of knowledge on the user-defined project requirements and their effort estimates and priorities, as well as their risk. This knowledge enables analys

  19. 30 CFR 756.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR INDIAN LANDS PROGRAM INDIAN TRIBE ABANDONED MINE LAND RECLAMATION PROGRAMS § 756.1 Scope. This part implements the provisions in Pub. L. 100-71 which authorize the Crow, Hopi, and Navajo Tribes to obtain the Secretary's...

  20. 19 CFR 111.0 - Scope.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 111.0 Section 111.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS BROKERS... to, persons desiring to transact customs business as customs brokers, including the...

  1. 77 FR 9893 - Notice of Scope Rulings

    Science.gov (United States)

    2012-02-21

    ... Bearings from the People's Republic of China. Requestor: New Trend Engineering Limited; its wheel hub units... Ltd.; its wheel hub units are within the scope of the antidumping duty order; June 14, 2011. A-570-803...-570-868: Folding Metal Tables and Chairs from the People's Republic of China. Requestor:...

  2. Every document has a geographical scope

    NARCIS (Netherlands)

    Andogah, G.; Bouma, G.; Nerbonne, J.

    2012-01-01

    It is a useful premise to assume that every document in a collection and every query issued to an information retrieval (IR) system are geography-dependent. If one can determine what area an article is about (i.e., its geographical scope), this information can be used to improve the accuracy with wh

  3. Quantifier Scope in Categorical Compositional Distributional Semantics

    Directory of Open Access Journals (Sweden)

    Mehrnoosh Sadrzadeh

    2016-08-01

    Full Text Available In previous work with J. Hedges, we formalised a generalised quantifiers theory of natural language in categorical compositional distributional semantics with the help of bialgebras. In this paper, we show how quantifier scope ambiguity can be represented in that setting and how this representation can be generalised to branching quantifiers.

  4. 1 CFR 9.2 - Scope.

    Science.gov (United States)

    2010-01-01

    ... ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER THE UNITED STATES GOVERNMENT MANUAL § 9.2 Scope. (a) The Manual shall contain appropriate information about the Executive... interest to warrant inclusion shall also be published in the Manual. ...

  5. 18 CFR 401.71 - Scope.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Scope. 401.71 Section 401.71 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL... and issues arising as a result of administrative actions and decisions taken or rendered by the...

  6. 49 CFR 193.2501 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 193.2501 Section 193.2501 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY LIQUEFIED NATURAL GAS FACILITIES...

  7. 49 CFR 193.2401 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 193.2401 Section 193.2401 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY LIQUEFIED NATURAL GAS FACILITIES...

  8. 49 CFR 193.2301 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 193.2301 Section 193.2301 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY LIQUEFIED NATURAL GAS FACILITIES...

  9. 49 CFR 193.2101 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 193.2101 Section 193.2101 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY LIQUEFIED NATURAL GAS FACILITIES...

  10. 12 CFR 13.1 - Scope.

    Science.gov (United States)

    2010-01-01

    ... COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY GOVERNMENT SECURITIES SALES PRACTICES § 13.1 Scope..., government securities brokers or dealers pursuant to section 15C of the Securities Exchange Act (15 U.S.C. 78o-5) and Department of the Treasury rules under section 15C (17 CFR 400.1(d) and part 401)....

  11. 45 CFR 95.1 - Scope.

    Science.gov (United States)

    2010-10-01

    ... ASSISTANCE, MEDICAL ASSISTANCE AND STATE CHILDREN'S HEALTH INSURANCE PROGRAMS) Time Limits for States To File Claims § 95.1 Scope. (a) This subpart establishes a two year time limit (15 months in some cases) for a... Children (except for Section 402(a)(19)(G) of the Act). Title IV-B—Child Welfare Services. Title...

  12. 10 CFR 434.101 - Scope.

    Science.gov (United States)

    2010-01-01

    ... BUILDINGS Administration and Enforcement-General § 434.101 Scope. 101.1 This part provides design requirements for the building envelope, electrical distribution systems and equipment for electric power... (3) A substantial renovation of a building for which design for construction began before January...

  13. 32 CFR 775.8 - Scoping.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Scoping. 775.8 Section 775.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES PROCEDURES FOR IMPLEMENTING THE... to be addressed and to identify the significant issues to be analyzed in depth related to...

  14. 78 FR 42934 - Notice of Scope Rulings

    Science.gov (United States)

    2013-07-18

    ... curtain walls with non-Chinese extrusions are not within the scope of the antidumping duty and...-917: Laminated Woven Sacks from the People's Republic of China Requestor: Laminated Woven Sacks Committee and its individual members; laminated woven sacks produced with two ink colors printed in...

  15. Relevance Measures Using Geographic Scopes and Types

    NARCIS (Netherlands)

    Andogah, Geoffrey; Bouma, Gosse; Peters, C; Jikoun,; Mandl, T; Muller, H; Oard, DW; Penas, A; Petras,; Santos, D

    2008-01-01

    This paper proposes two kinds of relevance measures to rank documents by geographic restriction: scope-based and type-based. The non-geographic and geographic relevance scores are combined using a weighted harmonic mean. The proposed relevance measures and weighting schemes are evaluated on GeoCLEF

  16. 31 CFR 800.101 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Scope. 800.101 Section 800.101 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF INVESTMENT... when provisions of law other than section 721 and the International Emergency Economic Powers Act (50...

  17. 45 CFR 670.2 - Scope.

    Science.gov (United States)

    2010-10-01

    ..., exporting or having custody, control, or possession of any mammal, bird, or plant native to Antarctica that... ANIMALS AND PLANTS Introduction § 670.2 Scope. The regulations in this part apply to: (a) Taking mammals, birds, or plants native to Antarctica. (b) Engaging in harmful interference of mammals, birds...

  18. 21 CFR 868.1 - Scope.

    Science.gov (United States)

    2010-04-01

    ... DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES General Provisions § 868.1 Scope. (a) This part sets forth the classification of anesthesiology... equivalent to other devices, as required by § 807.87. (c) To avoid duplicative listings, an...

  19. 78 FR 32372 - Notice of Scope Rulings

    Science.gov (United States)

    2013-05-30

    ... calendar quarter. FOR FURTHER INFORMATION CONTACT: Jennifer Moats, AD/CVD Operations, China/NME Group... Brands, LLC; 17 of its birthday candles are within the scope of the antidumping duty order; five of its... Countries A-201-837/A-570-954/C-570-955: Certain Magnesia Carbon Bricks From the People's Republic of China...

  20. Two Objections to Wide-Scoping

    NARCIS (Netherlands)

    Evers, Daan

    2011-01-01

    Wide-scopers argue that the detachment of intuitively false ‘ought’ claims from hypothetical imperatives is blocked because ‘ought’ takes wide, as opposed to narrow, scope. I present two arguments against this view. The first questions the premise that natural language conditionals are true just in

  1. 41 CFR 105-70.000 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Scope. 105-70.000 Section 105-70.000 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services Administration...

  2. 30 CFR 702.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... COAL EXTRACTION INCIDENTAL TO THE EXTRACTION OF OTHER MINERALS § 702.1 Scope. This part implements the exemption contained in section 701(28) of the Act concerning the extraction of coal incidental to the extraction of other minerals where coal does not exceed 162/3 percent of the total tonnage of coal and other...

  3. 30 CFR 707.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... COAL EXTRACTION INCIDENT TO GOVERNMENT-FINANCED HIGHWAY OR OTHER CONSTRUCTION § 707.1 Scope. (a) This... which are exempt from the Act and this chapter because the extraction of coal is an incidental part of... extraction of coal which is incidental to government-financed construction from the requirements of the Act...

  4. 49 CFR 232.601 - Scope.

    Science.gov (United States)

    2010-10-01

    ... TRANSPORTATION BRAKE SYSTEM SAFETY STANDARDS FOR FREIGHT AND OTHER NON-PASSENGER TRAINS AND EQUIPMENT; END-OF-TRAIN DEVICES Electronically Controlled Pneumatic (ECP) Braking Systems § 232.601 Scope. This subpart contains specific requirements applicable to freight trains and freight cars equipped with ECP...

  5. Scope Management of Non-Functional Requirements

    NARCIS (Netherlands)

    Kassab, M.; Daneva, Maia; Ormandjieva, O.; Mueller, P.; Lyggesmeyer, P.; Maehle, E.

    2007-01-01

    In order to meet commitments in software projects, a realistic assessment must be made of project scope. Such an assessment relies on the availability of knowledge on the user-defined project requirements and their effort estimates and priorities, as well as their risk. This knowledge enables

  6. 45 CFR 95.503 - Scope.

    Science.gov (United States)

    2010-10-01

    ... ASSISTANCE, MEDICAL ASSISTANCE AND STATE CHILDREN'S HEALTH INSURANCE PROGRAMS) Cost Allocation Plans § 95.503... 45 Public Welfare 1 2010-10-01 2010-10-01 false Scope. 95.503 Section 95.503 Public Welfare... Refugee Act of 1980, title IV, Chapter 2 of the Immigration and Nationality Act (8 U.S.C. 1521 et seq...

  7. 47 CFR 90.31 - Scope.

    Science.gov (United States)

    2010-10-01

    ... FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Industrial/Business Radio Pool § 90.31 Scope. The Industrial/Business Radio Pool covers the licensing of the radio communications of entities engaged in commercial activities, engaged in...

  8. 40 CFR 263.10 - Scope.

    Science.gov (United States)

    2010-07-01

    ... Scope. (d) A transporter of hazardous waste subject to the Federal manifesting requirements of 40 CFR... hazardous waste within the United States if the transportation requires a manifest under 40 CFR part 262... water, a transporter who meets all applicable requirements of 49 CFR parts 171 through 179 and...

  9. 48 CFR 970.4400 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Scope. 970.4400 Section 970.4400 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Management and Operating Contractor Purchasing 970.4400...

  10. 48 CFR 970.0808-00 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Scope. 970.0808-00 Section 970.0808-00 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Required sources of supplies and services 970.0808-00...

  11. 16 CFR 1501.2 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Scope. 1501.2 Section 1501.2 Commercial... IDENTIFYING TOYS AND OTHER ARTICLES INTENDED FOR USE BY CHILDREN UNDER 3 YEARS OF AGE WHICH PRESENT CHOKING... by children under 3 years (36 months) of age that are introduced into interstate commerce after...

  12. Consumer Behavior: Its Scope and Boundary.

    Science.gov (United States)

    Sirgy, M. Joseph

    Consumer behavior can be conceptualized by introducing a theoretical framework which defines its scope and boundary and identifies six developmental levels. The infancy stage, Level I, is the study of consumer behavior referred to as the scientific study of psychological structure and process dynamics of individuals consuming an economic good…

  13. 75 FR 79339 - Notice of Scope Rulings

    Science.gov (United States)

    2010-12-20

    ...: Academy Sports & Outdoors; whether its bistro sets, consisting of two chairs and a table, are outside the...: Blackstone OTR LLC and OTR Wheel Engineering, Inc.; whether its wheel hub assemblies are within the scope of... People's Republic of China Requestor: New Trend Engineering Ltd.; whether certain of its wheel...

  14. 12 CFR 334.40 - Scope.

    Science.gov (United States)

    2010-01-01

    ... FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY FAIR CREDIT REPORTING Duties of Furnishers of Information § 334.40 Scope. This subpart applies to a financial institution or... subsidiary of such entities (except dealers, persons providing insurance, investment companies,...

  15. On the Scope of Egalitarian Justice

    Directory of Open Access Journals (Sweden)

    Joseph Heath

    2006-05-01

    Full Text Available It is not clear whether the social contract is supposed to merely supplement the unequal gains that individuals are able to make through the exercise of their natural endowments with a set of equal gains secured through social cooperation, or whether the social contract must also compensate individuals for the effects of these natural inequalities, so that they literally become all equal. The issue concerns, in effect, whether natural inequality falls within the scope of egalitarian justice. I think it is fair to say that the majority of egalitarians assume that the principle of equality imposes an obligation to redress natural inequality. Yet there is no consensus on this issue. David Gauthier has made the rejection of the principle of redress a central component of his project. It has often escaped notice that John Rawls also rejects the principle of redress. Thus it is not just anti-egalitarians who reject the principle of redress. There is a current of egalitarian thought– which we might call, for lack of a better term, narrow-scope egalitarianism – which also rejects this principle. In this paper, I would like to show that there is considerable wisdom in the narrow-scope egalitarian position. Many of the problems that lead theorists to reject egalitarianism in its entirety are a consequence, not of the principle of equality per se, but rather of the commitment to redress natural inequality. The narrow-scope view avoids all of these difficulties.

  16. 40 CFR 792.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Scope. 792.1 Section 792.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED... fate testing. This part is intended to ensure the quality and integrity of data submitted pursuant to...

  17. 14 CFR 171.21 - Scope.

    Science.gov (United States)

    2010-01-01

    ... FACILITIES NON-FEDERAL NAVIGATION FACILITIES Nondirectional Radio Beacon Facilities § 171.21 Scope. (a) This... radio beacon facilities that are to be involved in the approval of instrument flight rules and air traffic control procedures related to those facilities. (b) A nondirectional radio beacon (“H”...

  18. 47 CFR 15.601 - Scope.

    Science.gov (United States)

    2010-10-01

    ... FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Access Broadband Over Power Line (Access BPL) § 15.601 Scope. This subpart sets out the regulations for Access Broadband over Power Line (Access BPL) devices operating in the 1.705-80 MHz band over medium or low voltage lines....

  19. 12 CFR 313.1 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Scope. 313.1 Section 313.1 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE PROCEDURES FOR CORPORATE DEBT... apply: (1) To debts or claims arising under the Internal Revenue Code of 1986 (Title 26, U.S. Code), the...

  20. 12 CFR 313.40 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Scope. 313.40 Section 313.40 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE PROCEDURES FOR CORPORATE DEBT... arising under the Internal Revenue Code, the tariff laws of the United States or to any case where...

  1. 47 CFR 73.401 - Scope.

    Science.gov (United States)

    2010-10-01

    ... FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Digital Audio Broadcasting § 73.401 Scope. This subpart contains those rules which apply exclusively to the digital audio broadcasting (DAB) service, and are in addition to those rules in Subparts A, B, C, G and...

  2. 22 CFR 8.3 - Scope.

    Science.gov (United States)

    2010-04-01

    ... personnel); (4) Has an organizational structure (e.g., officers) and a staff. (c) Where a group provides... DEPARTMENT OF STATE GENERAL ADVISORY COMMITTEE MANAGEMENT § 8.3 Scope. (a) The Federal Advisory Committee Act... Office of Management and Budget, may establish a group which shall be known as an advisory committee...

  3. 47 CFR 68.2 - Scope.

    Science.gov (United States)

    2010-10-01

    ... EQUIPMENT TO THE TELEPHONE NETWORK General § 68.2 Scope. (a) Except as provided in paragraphs (b) and (c) of... public switched telephone network for use in conjunction with all services other than party line services... telephone company provided communications network without compliance with this part, provided that...

  4. 76 FR 31301 - Notice of Scope Rulings

    Science.gov (United States)

    2011-05-31

    ...; requested June 14, 2010; initiated September 13, 2010. A-570-937/C-570-938: Citric Acid and Certain Citrate... citric acid and blends of citrate salts are within the scope of the antidumping duty and countervailing...-the-Road Tires from the People's Republic of China. Requestor: Wide Open Cycles Inc.; whether custom...

  5. 7 CFR 622.2 - Scope.

    Science.gov (United States)

    2010-01-01

    ... proper utilization of land, flood prevention, agricultural water management including irrigation and... 7 Agriculture 6 2010-01-01 2010-01-01 false Scope. 622.2 Section 622.2 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT...

  6. 7 CFR 701.3 - Scope.

    Science.gov (United States)

    2010-01-01

    ... participants on eligible land for certain practices, to rehabilitate farmland damaged by floods, hurricanes... 7 Agriculture 7 2010-01-01 2010-01-01 false Scope. 701.3 Section 701.3 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE...

  7. Combined biomass inventory in the scope of REDD (Reducing ...

    African Journals Online (AJOL)

    Combined biomass inventory in the scope of REDD (Reducing Emissions from Deforestation and Forest Degradation) ... This paper presents an approach for combined biomass inventories in the scope of future REDD regimes ... Article Metrics.

  8. Dealing with Quantifier Scope Ambiguity in Natural Language Understanding

    Science.gov (United States)

    Hafezi Manshadi, Mohammad

    2014-01-01

    Quantifier scope disambiguation (QSD) is one of the most challenging problems in deep natural language understanding (NLU) systems. The most popular approach for dealing with QSD is to simply leave the semantic representation (scope-) underspecified and to incrementally add constraints to filter out unwanted readings. Scope underspecification has…

  9. SCOPE : an intelligent maintenance system for supporting crew operations

    NARCIS (Netherlands)

    Bos, A.; Breebaart, L.; Neerincx, M.A.; Wolff, M.

    2004-01-01

    This paper describes an intelligent maintenance system for Supporting Crew OPErations (SCOPE). SCOPE supports the astronauts onboard the ISS and helps them to maximize the availability of complex payload systems. SCOPE detects system failures, guides the isolation of the root causes of failure, and

  10. 45 CFR 703.3 - Scope of subject matter.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Scope of subject matter. 703.3 Section 703.3... AND FUNCTIONS OF STATE ADVISORY COMMITTEES § 703.3 Scope of subject matter. The scope of the subject matter to be dealt with by Advisory Committees shall be those subjects of inquiry or study with which...

  11. 29 CFR 2.10 - Scope and purpose.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Scope and purpose. 2.10 Section 2.10 Labor Office of the Secretary of Labor GENERAL REGULATIONS Audiovisual Coverage of Administrative Hearings § 2.10 Scope and purpose. This subpart defines the scope of audiovisual coverage of departmental administrative...

  12. Examining Young Students' Problem Scoping in Engineering Design

    Science.gov (United States)

    Watkins, Jessica; Spencer, Kathleen; Hammer, David

    2014-01-01

    Problem scoping--determining the nature and boundaries of a problem--is an essential aspect of the engineering design process. Some studies from engineering education suggest that beginning students tend to skip problem scoping or oversimplify a problem. However, the ways these studies often characterize students' problem scoping often do not…

  13. 76 FR 43678 - Notice of Public Scoping Meetings and Extension of Scoping Period for the U.S. Department of...

    Science.gov (United States)

    2011-07-21

    ..., development, and extraction of uranium and vanadium ores. The ULP includes tracts of land located in Mesa... of Public Scoping Meetings and Extension of Scoping Period for the U.S. Department of Energy Uranium... meetings in western Colorado to receive comments on the scope of the DOE Uranium Leasing Program...

  14. Reduced attentional scope in cocaine polydrug users.

    Directory of Open Access Journals (Sweden)

    Lorenza S Colzato

    Full Text Available Cocaine is Europe's second preferred recreational drug after cannabis but very little is known about possible cognitive impairments in the upcoming type of recreational cocaine user (monthly consumption. We asked whether recreational use of cocaine impacts early attentional selection processes. Cocaine-free polydrug controls (n = 18 and cocaine polydrug users (n = 18 were matched on sex, age, alcohol consumption, and IQ (using the Raven's progressive matrices, and were tested by using the Global-Local task to measure the scope of attention. Cocaine polydrug users attended significantly more to local aspects of attended events, which fits with the idea that a reduced scope of attention may be associated with the perpetuation of the use of the drug.

  15. Latin American forensic pathology: scope and needs

    Directory of Open Access Journals (Sweden)

    Gabriel M. Fonseca

    2012-10-01

    Full Text Available Pathology pertains to the study of a disease; from ancient times it has sought to explain the cause of death through postmortem examination. The advancement of science and technology has led to a greater definition of roles and has favored its development through different subspecialties among which we stands out forensic pathology. This discipline has its own characteristics, scope, case series, procedures and terminology. Likewise, although forensic pathology does not differ substantially from clinical pathology, significant differences can be found between the Anglo American approach and the Latin American approach. Beyond semantics of these alleged differences, the article reviews the concepts involved and discusses the scope and requirements needed to qualify experts, in the understanding that globalizing criteria should establish new paradigms and define the specific roles of the specialty.

  16. Nature and scope of public administration

    Directory of Open Access Journals (Sweden)

    Uchem, R.O.

    2013-03-01

    Full Text Available The success and survival of any organizations be they government or not is contingent upon group efforts and cooperation to achieve set goals. This paper discusses the nature and scope of public administration to say that in modern day societies, any administration in the public interest transcends beyond government circles and finds expression in other spheres of human endeavors including the church, mosques, postal services as well as international relations and diplomacy, respectively. The paper discusses the concepts of administration and public administration thereby creating a distinction between the two concepts. Furthermore, the understanding of the scope of administration through the various schools of thought have also been captured, the essence of which is to generate a clearer understanding of the discourse under review. The paper ends with conclusions.

  17. Expanding Scope of Practice for Ontario Optometrists

    Directory of Open Access Journals (Sweden)

    Emily Bray

    2017-06-01

    Full Text Available In 2011, The Optometry Act, 1991 was amended to include The Designated Drugs and Standards of Practice Regulation which expanded the scope of practice for Ontario optometrists to include prescribing privileges from a specific list of drugs. The goals of the optometry reform were to increase access to care, decrease burden on medical and hospital resources and allow optometrists to practice to their full scope. The policy response was spurred by a recommendation from the Health Professions Regulatory Advisory Council and the prescribing precedence in other Canadian jurisdictions. Bill 171, The Health Systems Improvement Act, amended The Optometry Act, 1991, Section 4 to include the authorized act of prescribing designated drugs, while The Designated Drugs and Standards of Practice, passed on 6 April 2011, listed the individual drugs optometrists are authorized to prescribe. The resulting response of a specific list of authorized drugs was seen as a limiting and inflexible system that will require changes as newer drugs are developed.

  18. 40 CFR 81.300 - Scope.

    Science.gov (United States)

    2010-07-01

    ... CFR 51.100 and § 81.1 (i) Early Action Compact. The term “early action compact” (“compact”) means an... Air Act (42 U.S.C. 7401 et seq.) codified at 40 CFR 50.10. (2) What Are Early Action Compact Areas... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Scope. 81.300 Section...

  19. Groundwater and climate change research scoping study

    OpenAIRE

    Jackson, C. R.; Cheetham, M.; Guha, P

    2006-01-01

    This scoping study has reviewed much of the published literature in the field of climate change and groundwater research. Whilst it is not exhaustive with regard to groundwater quality issues, most of the published literature relating to climate change and groundwater resources, particularly in the UK, is covered. Further work is required to identify current research needs relating to the effects of climate change on groundwater quality. The study of the effects of climate chan...

  20. How the Cloud Stretches the SOA Scope

    Directory of Open Access Journals (Sweden)

    Lakshmanan G

    2012-09-01

    Full Text Available In this article, we will describe how the enterprise serviceoriented-architecture (SOA scope is stretched with the advent of cloud computing. With the help of the case study of a fictitious global retailer, we will demonstrate the process for identifying cloud scenarios. Also, we will come across an emerging breed of distributed applications—both on-premise and in the Cloud—and discuss the integration considerations for building them.

  1. Revising the Complex Economics of Patent Scope

    DEFF Research Database (Denmark)

    Howells, John

    Merges and Nelson claim to have provided an empirically grounded argument that pioneer patents of 'broad' scope are used to block technological development. It is widely understood in both law and economics that they have, as they claim, faulted Kitch's 'prospect theory' of patents, a theory that...... of development. This interpretation restores the credibility of Kitch's prospect theory of patent function and emphasises that the administration of the patent institution should be designed to support the prospect function of patents.......Merges and Nelson claim to have provided an empirically grounded argument that pioneer patents of 'broad' scope are used to block technological development. It is widely understood in both law and economics that they have, as they claim, faulted Kitch's 'prospect theory' of patents, a theory...... that a function of patents is to enable the coordinated development of novel technical ideas. This article is a critical review of Merges and Nelson's historical empirical evidence. I find that, first, 'broad' scope is only implicated in one of the examples cited by Merges and Nelson as supportive evidence...

  2. Biomechanics of fencing sport: A scoping review

    Science.gov (United States)

    Chen, Tony Lin-Wei; Wong, Duo Wai-Chi; Wang, Yan; Ren, Sicong; Yan, Fei

    2017-01-01

    Objectives The aim of our scoping review was to identify and summarize current evidence on the biomechanics of fencing to inform athlete development and injury prevention. Design Scoping review. Method Peer-reviewed research was identified from electronic databases using a structured keyword search. Details regarding experimental design, study group characteristics and measured outcomes were extracted from retrieved studies, summarized and information regrouped under themes for analysis. The methodological quality of the evidence was evaluated. Results Thirty-seven peer-reviewed studies were retrieved, the majority being observational studies conducted with experienced and elite athletes. The methodological quality of the evidence was “fair” due to the limited scope of research. Male fencers were the prevalent group studied, with the lunge and use of a foil weapon being the principal movement evaluated. Motion capture and pedabarography were the most frequently used data collection techniques. Conclusions Elite fencers exhibited sequential coordination of upper and lower limb movements with coherent patterns of muscle activation, compared to novice fencers. These elite features of neuromuscular coordination resulted in higher magnitudes of forward linear velocity of the body center of mass and weapon. Training should focus on explosive power. Sex- and equipment-specific effects could not be evaluated based on available research. PMID:28187164

  3. The decision - identification tree: A new EIS scoping tool

    Energy Technology Data Exchange (ETDEWEB)

    Eccleston, C.H.

    1997-04-02

    No single methodology has been developed or universally accepted for determining the scope of an Environmental Impact Statement (EIS). Most typically, the scope is determined by first identifying actions and facilities to be analyzed. Yet, agencies sometimes complete an EIS, only to discover that the scope does not adequately address decisions that need to be made. Such discrepancies can often be traced to disconnects between the scoping process and the actual decision making that follows. A new tool, for use in a value engineering setting, provides an effective methodology for improving the EIS scoping process. Application of this tool is not limited to National Environmental Policy Act (NEPA) scoping efforts. This tool, could in fact, be used to map potential decision points for a range of diverse planning applications and exercises.

  4. Fuzzy decision analysis for project scope change management

    Directory of Open Access Journals (Sweden)

    Farshad Shirazi

    2017-09-01

    Full Text Available It is very important to manage and control projects with the consideration of the triple constraints; namely time, cost and scope. It is also extremely important to manage the scope and all the procurements needed to complete any project. During the project’s lifecycle many changes take place, either positively or negatively, which should be controlled. If the changes are not controlled we may have scope creep that has negative effect on the project. It is commonly considered a negative incident, and thus, should be kept away from the project. By considering this concept, in this paper, we discuss scope change and managing scope and fuzzy analytical hierarchy process is used in selecting the best strategy to manage scope change in projects.

  5. Definition and scope of health services administration.

    Science.gov (United States)

    Begun, James W; Kaissi, Amer

    2004-01-01

    The definition and scope of health services administration are important to public policy, educational programs, new entrants to the field, and practitioners. Formal definition of the field of health services administration has not received concerted attention since 1975. Significant changes in the field have occurred since that time, widening opportunities for graduates of educational programs and increasing interdependencies between health services organizations and public policy organizations, supplier organizations, insurers, and other businesses that are not involved directly in health services delivery. Stakeholders in the field of health services administration should consider a broadened definition of the field that would institutionalize and build on those increased opportunities and interdependencies.

  6. Tokamak Engineering Technology Facility scoping study

    Energy Technology Data Exchange (ETDEWEB)

    Stacey, W.M. Jr.; Abdou, M.A.; Bolta, C.C.

    1976-03-01

    A scoping study for a Tokamak Engineering Technology Facility (TETF) is presented. The TETF is a tokamak with R = 3 m and I/sub p/ = 1.4 MA based on the counterstreaming-ion torus mode of operation. The primary purpose of TETF is to demonstrate fusion technologies for the Experimental Power Reactor (EPR), but it will also serve as an engineering and radiation test facility. TETF has several technological systems (e.g., superconducting toroidal-field coil, tritium fuel cycle, impurity control, first wall) that are prototypical of EPR.

  7. Probiotics in 2015: Their Scope and Use.

    Science.gov (United States)

    Sanders, Mary Ellen

    2015-01-01

    The field of probiotics continues to evolve and progress. This paper reviews several situations within the probiotic field that are of current interest, including review of the scope of the proper use of the term "probiotic," use of systematic reviews and meta-analyses for probiotics, regulatory challenges to doing human research on probiotics in the United States, medical recommendations for probiotic use, and safety assurance for probiotics used for vulnerable populations. The greatest need in the probiotic field remains well-conducted and well-reported human trials, to better define the functionality of probiotics for different indications and populations.

  8. What We Mean by Scope and Methods: A Survey of Undergraduate Scope and Methods Courses

    Science.gov (United States)

    Turner, Charles C.; Thies, Cameron G.

    2009-01-01

    Self-reflective political scientists have extensively reviewed the history of the discipline and argued over its future, but to date there has been little effort to systematically survey undergraduate scope and methods courses (for an exception see Thies and Hogan 2005). This lack of data leaves the discipline unable to assess how much we are…

  9. Prioritising Project Scope Definition Elements in Public Building Projects

    Directory of Open Access Journals (Sweden)

    Mohammed K Fageha

    2014-09-01

    Full Text Available A complete definition of the scope of a project upfront during early stages ensures smooth and successful implementation during the project execution. This research identifies and prioritises project scope definition elements for public buildings in Saudi Arabia. Elements that could significantly contribute to complete project scope definition package at pre-project planning stage are identified and their interrelationship determined and prioritised. Using the Project Definition Rating Index (PDRI as a basis, the study uses analytical network process (ANP technique based on data obtained from project managers who have been involved in public sector projects in Saudi Arabia. Data collection and analysis was conducted in three steps. The first step involved identification of scope definition elements while the second involved an investigation into interrelationships among the elements. In the third step, ANP was used to determine the weight of the elements’ importance in terms of contribution to project scope definition completeness. Finally, Pareto analysis was used to prioritise and assess the distribution pattern of the elements. The outcome from this research is the prioritisation of project scope definition elements for public building projects in Saudi Arabia. The prioritised list developed indicates the importance of project scope definition elements. It should help project management teams identify elements to consider when evaluating project scope definition for completeness at the pre-project planning stage. Keywords: Project scope definition, pre-project planning, prioritising, public building projects, Saudi Arabia, Analytical Network Process (ANP

  10. 48 CFR 225.7500 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Balance of Payments Program 225.7500 Scope of subpart. This subpart provides policies and procedures implementing the Balance of Payments Program....

  11. EarthScope Education and Outreach: Accomplishments and Emerging Opportunities

    Science.gov (United States)

    Robinson, S.; Ellins, K. K.; Semken, S. C.; Arrowsmith, R.

    2014-12-01

    EarthScope's Education and Outreach (E&O) program aims to increase public awareness of Earth science and enhance geoscience education at the K-12 and college level. The program is distinctive among major geoscience programs in two ways. First, planning for education and public engagement occurred in tandem with planning for the science mission. Second, the NSF EarthScope program includes funding support for education and outreach. In this presentation, we highlight key examples of the program's accomplishments and identify emerging E&O opportunities. E&O efforts have been collaboratively led by the EarthScope National Office (ESNO), IRIS, UNAVCO, the EarthScope Education and Outreach Subcommittee (EEOSC) and PI-driven EarthScope projects. Efforts by the EEOSC, guided by an EarthScope Education and Outreach Implementation Plan that is periodically updated, focus EarthScope E&O. EarthScope demonstrated early success in engaging undergraduate students (and teachers) in its mission through their involvement in siting USArray across the contiguous U.S. Funded E&O programs such as TOTLE, Illinois EarthScope, CEETEP (for K-12), InTeGrate and GETSI (for undergraduates) foster use of freely available EarthScope data and research findings. The Next Generation Science Standards, which stress science and engineering practices, offer an opportunity for alignment with existing EarthScope K-12 educational resources, and the EEOSC recommends focusing efforts on this task. The EEOSC recognizes the rapidly growing use of mobile smart devices by the public and in formal classrooms, which bring new opportunities to connect with the public and students. This will capitalize on EarthScope's already prominent social media presence, an effort that developed to accomplish one of the primary goals of the EarthScope E&O Implementation Plan to "Create a high-profile public identity for EarthScope" and to "Promote science literacy and understanding of EarthScope among all audiences through

  12. CMS Phase II Upgrade Scope Document

    CERN Document Server

    Butler, J; Klute, M; Mans, J; Silvestris, L; on behalf of the CMS, Collaboration; CERN. Geneva. The LHC experiments Committee; LHCC

    2015-01-01

    The High-Luminosity LHC (HL-LHC) has been identified as the highest priority program in High Energy Physics by both the European Strategy Group and the US Particle Physics Project Prioritization Panel. To fulfil the full potential of this program, which includes the study of the nature of the Higgs boson, the investigation of the properties of any newly discovered particles in the upcoming LHC runs, and the extension of the mass reach for further discoveries, an integrated luminosity of 3000 fb-1 will have to be accumulated by the end of the program. In preparation for operation at the HL-LHC , CMS has documented the necessary upgrades and their expected costs in a Technical Proposal submitted to the CERN LHC Committee (LHCC) in mid-2015. The material presented in the current “Scope Document” provides additional information to assist the LHCC and the CERN Resource Review Board (RRB) in their review of the CMS upgrade. The document commences with a summary of the process followed to develop the scope of t...

  13. Medicinal chemistry of 2,2,4-substituted morpholines.

    Science.gov (United States)

    Rekka, E A; Kourounakis, P N

    2010-01-01

    We have designed a number of 2-hydroxy (alkoxy)-2-aryl-4-alkyl-(5,6-alkyl)-morpholines with interesting biological activities, i.e. sympathomimetic, analgesic, drug metabolizing enzyme modulating ability, antioxidant potential, anti-inflammatory and anti-dyslipidemic properties. They are synthesised by reaction of the proper 2-aminoethanol with aryl-bromomethyl-ketone. The intermediate hydroxyaminoketone is spontaneously cyclised to form the tetrahydro-1,4-oxazine ring. The produced 2-hydroxy substituted morpholines form the 2-alkoxy derivatives. The 2-hydroxy or 2-alkoxy-1,4-oxazine derivatives can lose water or alcohol, to give styrene-type products. The conditions for oxazine ring formation and water or alcohol abstraction are investigated. Ionisation constants and partition coefficients have been determined and related to structure and activity. The biological activities of these compounds are quite interesting: The 2-phenyl analogues acquire the structural requirements for sympathomimetic amines, and present a structure related to the pethidine-type analgesics. Indeed, they show central dopaminergic and analgesic, antagonized by naloxone, activities. They also affect drug metabolising enzymes. The 2- phenyl and especially the 2-biphenyl derivatives are good antioxidants, also possessing anti-inflammatory and immunomodulating action. The later class of compounds reduces remarkably plasma triglycerides, total cholesterol and LDL-cholesterol in hyperlipidemic rats. Since NO plays a multiple role in atheromatosis and inflammation, some 2-nitroxy-alkoxy derivatives are synthesized and their NO-liberating ability assessed. These nitric esters are also found to be potent hypolipidemic-hypocholesterolemic agents. In a mechanism elucidation attempt, it is indicated that these derivatives may act as squalene synthase inhibitors.

  14. Synthesis and Bioassay of 4-Substituted 2-Oxoglutaric Acids

    Institute of Scientific and Technical Information of China (English)

    Qiu Yun CHEN; Qing Shan LIU; Christopher J. SCHOFIELD

    2006-01-01

    Three 2-oxoglutaric acid analogues were synthesized. Their interaction with factorinhibiting hypoxia-inducible factor (FIH) was studied using LC-MS method. The results show that hydrophobic substitutes of 2-oxoglutaric acids have great influence on their inhibitor activity.

  15. 12 CFR 715.1 - Scope of this part.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Scope of this part. 715.1 Section 715.1 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS SUPERVISORY COMMITTEE AUDITS AND VERIFICATIONS § 715.1 Scope of this part. This part implements section 202(a)(6)(D)...

  16. 42 CFR 403.200 - Basis and scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Basis and scope. 403.200 Section 403.200 Public... PROVISIONS SPECIAL PROGRAMS AND PROJECTS Medicare Supplemental Policies § 403.200 Basis and scope. (a... intent of that section is to enable Medicare beneficiaries to identify Medicare supplemental...

  17. 16 CFR 1209.1 - Scope and application.

    Science.gov (United States)

    2010-01-01

    ... SAFETY STANDARD FOR CELLULOSE INSULATION The Standard § 1209.1 Scope and application. (a) Scope. This... requirements for cellulose insulation that is a consumer product. These requirements are intended to reduce or eliminate an unreasonable risk of injury to consumers from flammable and corrosive cellulose insulation. The...

  18. 16 CFR 1404.1 - Scope, application, and effective date.

    Science.gov (United States)

    2010-01-01

    ... REGULATIONS CELLULOSE INSULATION § 1404.1 Scope, application, and effective date. (a) Scope. This part 1404 establishes a requirement for manufacturers, including importers, of cellulose insulation to notify (1... exists where cellulose insulation is installed too close to the sides or over the top of a recessed...

  19. 48 CFR 927.200 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Scope of subpart. 927.200 Section 927.200 Federal Acquisition Regulations System DEPARTMENT OF ENERGY GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patents 927.200 Scope of subpart. When consulting 48 CFR part...

  20. 41 CFR 101-27.201 - Scope of subpart.

    Science.gov (United States)

    2010-07-01

    ...-Management of Shelf-Life Materials § 101-27.201 Scope of subpart. This subpart provides for the... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Scope of subpart. 101-27.201 Section 101-27.201 Public Contracts and Property Management Federal Property Management...

  1. 29 CFR 552.2 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... FAIR LABOR STANDARDS ACT TO DOMESTIC SERVICE General Regulations § 552.2 Purpose and scope. (a) This... accordance with the following amendments made by the Fair Labor Standards Amendments of 1974, 88 Stat. 55, et... 29 Labor 3 2010-07-01 2010-07-01 false Purpose and scope. 552.2 Section 552.2 Labor Regulations...

  2. 29 CFR 531.2 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Purpose and scope. 531.2 Section 531.2 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS WAGE PAYMENTS UNDER THE FAIR LABOR STANDARDS ACT OF 1938 Preliminary Matters § 531.2 Purpose and scope. (a) Section 3(m...

  3. Radiological Scoping Survey of the Scotia Depot Scotia, New York

    Energy Technology Data Exchange (ETDEWEB)

    E. N. Bailey

    2005-02-05

    At the request of the Defense Logistics Agency, the Oak Ridge Institute for Science and Education conducted radiological scoping surveys of the Scotia Depot during the period of September 24 through 27, 2007. The scoping survey included visual inspections and limited radiological surveys performed in accordance with area classification that included surface scans, total and removable activity measurements, and soil sampling.

  4. 39 CFR 262.1 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Purpose and scope. 262.1 Section 262.1 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.1 Purpose and scope. This part contains the official definition of those basic records...

  5. 10 CFR 63.201 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Purpose and scope. 63.201 Section 63.201 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Preclosure Public Health and Environmental Standards § 63.201 Purpose and scope....

  6. 10 CFR 63.301 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Purpose and scope. 63.301 Section 63.301 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Postclosure Public Health and Environmental Standards § 63.301 Purpose and scope....

  7. 42 CFR 410.1 - Basis and scope.

    Science.gov (United States)

    2010-10-01

    ... SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS General Provisions § 410.1 Basis and scope. (a) Statutory basis...—Scope of benefits furnished under the Medicare Part B supplementary medical insurance (SMI) program. (2) Section 1833 through 1835 and 1862—Amounts of payment for SMI services, the conditions for payment,...

  8. 12 CFR 343.10 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Purpose and scope. 343.10 Section 343.10 Banks... CONSUMER PROTECTION IN SALES OF INSURANCE § 343.10 Purpose and scope. This part establishes consumer protections in connection with retail sales practices, solicitations, advertising, or offers of any...

  9. 14 CFR 437.7 - Scope of an experimental permit.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Scope of an experimental permit. 437.7..., DEPARTMENT OF TRANSPORTATION LICENSING EXPERIMENTAL PERMITS General Information § 437.7 Scope of an experimental permit. An experimental permit authorizes launch or reentry of a reusable suborbital rocket....

  10. 7 CFR 1773.38 - Scope of engagement.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Scope of engagement. 1773.38 Section 1773.38 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF... § 1773.38 Scope of engagement. (a) RUS requires that the audit procedures set forth in §§ 1773.39...

  11. 10 CFR 2.1200 - Scope of subpart L.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Scope of subpart L. 2.1200 Section 2.1200 Energy NUCLEAR... Hearing Procedures for NRC Adjudications § 2.1200 Scope of subpart L. The provisions of this subpart... and request the application of Subpart L procedures, and proceedings for the direct or indirect...

  12. 48 CFR 29.000 - Scope of part.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Scope of part. 29.000 Section 29.000 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS TAXES 29.000 Scope of part. This part prescribes policies and procedures for (a) using tax...

  13. 32 CFR 536.119 - Scope for maritime claims.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Scope for maritime claims. 536.119 Section 536.119 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY CLAIMS AND ACCOUNTS CLAIMS AGAINST THE UNITED STATES Maritime Claims § 536.119 Scope for maritime claims. The AMCSA applies worldwide and includes claims that arise on...

  14. 28 CFR 512.10 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Purpose and scope. 512.10 Section 512.10 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE GENERAL MANAGEMENT AND ADMINISTRATION RESEARCH Research § 512.10 Purpose and scope. General provisions for the protection of human...

  15. 10 CFR 2.1000 - Scope of subpart J.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Scope of subpart J. 2.1000 Section 2.1000 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Procedures... Geologic Repository § 2.1000 Scope of subpart J. The rules in this subpart, together with the rules...

  16. 24 CFR 17.60 - Scope and definitions.

    Science.gov (United States)

    2010-04-01

    ... § 17.60 Scope and definitions. (a) Scope. This subpart sets forth the regulations of the Secretary of... Federal Debt Collection Act of 1982 (31 U.S.C. 3701 et seq.) (the Act), in conformity with the standards... the Social Security Act where the withholding is required by law; (8) Amounts mandatorily withheld for...

  17. Internationalization of the Counseling Profession: Meaning, Scope and Concerns

    Science.gov (United States)

    Ng, Kok-Mun; Noonan, Brigid M.

    2012-01-01

    The present study sought to clarify the meaning and delineate the scope of internationalization of the counseling profession. Using a qualitative approach, the study recruited a panel of eight experts to help generate a consensus statement on the meaning of internationalization to the counseling profession and to delineate a five-theme scope of…

  18. Literacy Teaching Aids from High/Scope Educational Research Foundation

    Science.gov (United States)

    Science Activities: Classroom Projects and Curriculum Ideas, 2005

    2005-01-01

    High/Scope's approach to education is a blend of Jean Piaget's constructivist theory of child development and the best of traditional teacher experience. The High/Scope approach is about helping students gain knowledge and skills in important content areas, such as language and literacy, initiative and social relations, movement, music, and…

  19. 40 CFR 710.4 - Scope of the inventory.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Scope of the inventory. 710.4 Section... ACT TSCA CHEMICAL INVENTORY REGULATIONS General Provisions § 710.4 Scope of the inventory. (a... is extracted from air by any means, will automatically be included in the inventory under...

  20. 42 CFR 403.800 - Basis and scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Basis and scope. 403.800 Section 403.800 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... Program § 403.800 Basis and scope. (a) Basis. This subpart is based on section 1860D-31 of the...

  1. 45 CFR 150.403 - Scope of ALJ's authority.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Scope of ALJ's authority. 150.403 Section 150.403 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.403 Scope of...

  2. 10 CFR 2.1300 - Scope of subpart M.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Scope of subpart M. 2.1300 Section 2.1300 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Procedures for Hearings on License Transfer Applications § 2.1300 Scope of subpart M. The provisions of...

  3. 48 CFR 4.800 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Scope of subpart. 4.800 Section 4.800 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Government Contract Files 4.800 Scope of subpart. This subpart prescribes requirements...

  4. Scope insensitivity in contingent valuation of complex environmental amenities.

    Science.gov (United States)

    Veisten, Knut; Fredrik Hoen, Hans; Navrud, Ståle; Strand, Jon

    2004-12-01

    It has been argued that respondents in contingent valuation (CV) surveys, asked to value complex environmental amenities, will state willingness to pay (WTP) independently of the scope of the project. Such insensitivity to scope would be at odds with rational choice, and could therefore imply that CV is not a theoretically valid method for biodiversity valuation. The scope test in the present CV study was applied to endangered species preservation. Respondents were split in four sub-samples facing different scopes of endangered species preservation. The design allowed for both external and internal scope tests. Furthermore, the tests were split according to elicitation format. Of four external tests of insensitivity to scope, one was rejected, two gave mixed results, depending on either the type of test or elicitation format, and for the last one the null hypothesis could not be rejected. Of five internal tests, insensitivity to scope was rejected in three cases, one test gave mixed results, and one could not be rejected. Survey design features of the CV study, especially an unfamiliar sub-group of endangered species, could explain the apparent insensitivity to scope observed.

  5. 10 CFR 2.1103 - Scope of subpart K.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Scope of subpart K. 2.1103 Section 2.1103 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Hybrid... § 2.1103 Scope of subpart K. The provisions of this subpart, together with subpart C and applicable...

  6. 27 CFR 479.81 - Scope of tax.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Scope of tax. 479.81... EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN OTHER FIREARMS Transfer Tax § 479.81 Scope of tax. Except as otherwise provided in this part,...

  7. 41 CFR 105-1.000-50 - Scope of part.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Scope of part. 105-1.000-50 Section 105-1.000-50 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION § 105-1.000-50 Scope of part...

  8. 12 CFR 339.1 - Authority, purpose, and scope.

    Science.gov (United States)

    2010-01-01

    ... POLICY LOANS IN AREAS HAVING SPECIAL FLOOD HAZARDS § 339.1 Authority, purpose, and scope. (a) Authority... Flood Disaster Protection Act of 1973, as amended (42 U.S.C. 4001-4129). (c) Scope. This part, except... in areas determined by the Director of the Federal Emergency Management Agency to have special flood...

  9. 12 CFR 1101.1 - Scope and purpose.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Scope and purpose. 1101.1 Section 1101.1 Banks and Banking FEDERAL FINANCIAL INSTITUTIONS EXAMINATION COUNCIL DESCRIPTION OF OFFICE, PROCEDURES, PUBLIC INFORMATION § 1101.1 Scope and purpose. This part implements the Freedom of Information Act (FOIA), 5 U.S.C. 552, with respect to the...

  10. 41 CFR 101-28.000 - Scope of part.

    Science.gov (United States)

    2010-07-01

    ... Scope of part. This part prescribes policy and procedures for the economical and efficient management of... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Scope of part. 101-28.000 Section 101-28.000 Public Contracts and Property Management Federal Property Management Regulations...

  11. 11 CFR 9008.50 - Scope and definitions.

    Science.gov (United States)

    2010-01-01

    ... encouragement of commerce in the convention city, as well as the projection of a favorable image of the city to... Representing a Convention City § 9008.50 Scope and definitions. (a) Scope. This subpart B governs registration and reporting by host committees and municipal funds representing convention cities....

  12. 29 CFR 547.0 - Scope and effect of part.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Scope and effect of part. 547.0 Section 547.0 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS REQUIREMENTS OF A âBONA FIDE THRIFT OR SAVINGS PLANâ § 547.0 Scope and effect of part. (a) The regulations in this...

  13. 31 CFR 203.9 - Scope of the subpart.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Scope of the subpart. 203.9 Section 203.9 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE... LOAN PROGRAM Electronic Federal Tax Payments § 203.9 Scope of the subpart. This subpart prescribes...

  14. Literacy Teaching Aids from High/Scope Educational Research Foundation

    Science.gov (United States)

    Science Activities: Classroom Projects and Curriculum Ideas, 2005

    2005-01-01

    High/Scope's approach to education is a blend of Jean Piaget's constructivist theory of child development and the best of traditional teacher experience. The High/Scope approach is about helping students gain knowledge and skills in important content areas, such as language and literacy, initiative and social relations, movement, music, and…

  15. 40 CFR 716.1 - Scope and compliance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Scope and compliance. 716.1 Section 716.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT HEALTH AND SAFETY DATA REPORTING General Provisions § 716.1 Scope and compliance. (a) This subpart...

  16. 40 CFR 791.1 - Scope and authority.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Scope and authority. 791.1 Section 791.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) DATA REIMBURSEMENT General Provisions § 791.1 Scope and authority. (a) This part establishes...

  17. 12 CFR 41.20 - Scope and definitions.

    Science.gov (United States)

    2010-01-01

    ... Affiliate Marketing § 41.20 Scope and definitions. (a) Scope. This subpart applies to national banks...-existing business relationship. (i) In general. The term “pre-existing business relationship” means a relationship between a person, or a person's licensed agent, and a consumer based on— (A) A financial...

  18. 18 CFR 1b.3 - Scope of investigations.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Scope of investigations. 1b.3 Section 1b.3 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.3 Scope of investigations....

  19. 5 CFR 179.301 - Scope of regulations.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Scope of regulations. 179.301 Section 179.301 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS Administrative Offset § 179.301 Scope of regulations. These regulations apply to...

  20. Using SCOPE to identify potential regulatory motifs in coregulated genes.

    Science.gov (United States)

    Martyanov, Viktor; Gross, Robert H

    2011-05-31

    SCOPE is an ensemble motif finder that uses three component algorithms in parallel to identify potential regulatory motifs by over-representation and motif position preference. Each component algorithm is optimized to find a different kind of motif. By taking the best of these three approaches, SCOPE performs better than any single algorithm, even in the presence of noisy data. In this article, we utilize a web version of SCOPE to examine genes that are involved in telomere maintenance. SCOPE has been incorporated into at least two other motif finding programs and has been used in other studies. The three algorithms that comprise SCOPE are BEAM, which finds non-degenerate motifs (ACCGGT), PRISM, which finds degenerate motifs (ASCGWT), and SPACER, which finds longer bipartite motifs (ACCnnnnnnnnGGT). These three algorithms have been optimized to find their corresponding type of motif. Together, they allow SCOPE to perform extremely well. Once a gene set has been analyzed and candidate motifs identified, SCOPE can look for other genes that contain the motif which, when added to the original set, will improve the motif score. This can occur through over-representation or motif position preference. Working with partial gene sets that have biologically verified transcription factor binding sites, SCOPE was able to identify most of the rest of the genes also regulated by the given transcription factor. Output from SCOPE shows candidate motifs, their significance, and other information both as a table and as a graphical motif map. FAQs and video tutorials are available at the SCOPE web site which also includes a "Sample Search" button that allows the user to perform a trial run. Scope has a very friendly user interface that enables novice users to access the algorithm's full power without having to become an expert in the bioinformatics of motif finding. As input, SCOPE can take a list of genes, or FASTA sequences. These can be entered in browser text fields, or read from

  1. Insensitivity to Scope in Contingent Valuation Studies

    DEFF Research Database (Denmark)

    Søgaard, Rikke; Lindholt, Jes Sanddal; Gyrd-Hansen, Dorte

    2012-01-01

    insensitivity and to assess the relevance of potential explanations that may help to shed light on how to appropriately handle this problem in contingent valuation studies. Methods: We surveyed a sample of 2004 men invited for cardiovascular disease screening. Each respondent had three contingent valuation...... tasks from which their sensitivity to larger risk reductions (test 1) and to change in travel costs associated with participation (test 2) could be assessed. Participants were surveyed while waiting for their screening session. Non-participants were surveyed by postal questionnaire. Results: The sample...... was overall found to be sensitive to scope, testing at the conventional sample-mean level. At the individual respondent level, however, more than half of the respondents failed the tests. Potential determinants for failing the tests were examined in alternative regression models but few consistent...

  2. Scope of algae as third generation biofuels

    Directory of Open Access Journals (Sweden)

    Shuvashish eBehera

    2015-02-01

    Full Text Available An initiative has been taken to develop different solid, liquid and gaseous biofuels as the alternative energy resources. The current research and technology based on the third generation biofuels derived from algal biomass have been considered as the best alternative bioresource that avoids the disadvantages of first and second generation biofuels. Algal biomass have been investigated for the implementation of economic conversion processes producing different biofuels such as biodiesel, bioethanol, biogas, biohydrogen and other valuable co-products. In the present review, the recent findings and advance developments in algal biomass for improved biofuel production. This review discusses about the importance of the algal cell contents, various strategies for product formation through various conversion technologies, and its future scope as an energy security.

  3. Scope of algae as third generation biofuels.

    Science.gov (United States)

    Behera, Shuvashish; Singh, Richa; Arora, Richa; Sharma, Nilesh Kumar; Shukla, Madhulika; Kumar, Sachin

    2014-01-01

    An initiative has been taken to develop different solid, liquid, and gaseous biofuels as the alternative energy resources. The current research and technology based on the third generation biofuels derived from algal biomass have been considered as the best alternative bioresource that avoids the disadvantages of first and second generation biofuels. Algal biomass has been investigated for the implementation of economic conversion processes producing different biofuels such as biodiesel, bioethanol, biogas, biohydrogen, and other valuable co-products. In the present review, the recent findings and advance developments in algal biomass for improved biofuel production have been explored. This review discusses about the importance of the algal cell contents, various strategies for product formation through various conversion technologies, and its future scope as an energy security.

  4. REBUILD AMERICA PROGRAM SCOPE OF WORK

    Energy Technology Data Exchange (ETDEWEB)

    Jeffrey Brown; Bruce Exstrum

    2004-12-01

    This report summarizes the activities carried out by Aspen Systems Corporation in support of the Department of Energy's Rebuild America program during the period from October 9, 1999 to October 31, 2004. These activities were in accordance with the Scope of Work contained in a GSA MOBIS schedule task order issued by the National Energy Technology Laboratory. This report includes descriptions of activities and results in the following areas: deployment/delivery model; program and project results; program representative support activities; technical assistance; web site development and operation; business/strategic partners; and training/workshop activities. The report includes conclusions and recommendations. Five source documents are also provided as appendices.

  5. The AuScope Geodetic VLBI Array

    CERN Document Server

    Lovell, J E J; Reid, P B; McCulloch, P M; Baynes, B E; Dickey, J M; Shabala, S S; Watson, C S; Titov, O; Ruddick, R; Twilley, R; Reynolds, C; Tingay, S J; Shield, P; Adada, R; Ellingsen, S P; Morgan, J S; Bignall, H E; 10.1007/s00190-013-0626-3

    2013-01-01

    The AuScope geodetic Very Long Baseline Interferometry array consists of three new 12 m radio telescopes and a correlation facility in Australia. The telescopes at Hobart (Tasmania), Katherine (Northern Territory) and Yarragadee (Western Australia) are co-located with other space geodetic techniques including Global Navigation Satellite Systems (GNSS) and gravity infrastructure, and in the case of Yarragadee, Satellite Laser Ranging (SLR) and Doppler Orbitography and Radiopositioning Integrated by Satellite (DORIS) facilities. The correlation facility is based in Perth (Western Australia). This new facility will make significant contributions to improving the densification of the International Celestial Reference Frame in the Southern Hemisphere, and subsequently enhance the International Terrestrial Reference Frame through the ability to detect and mitigate systematic error. This, combined with the simultaneous densification of the GNSS network across Australia will enable the improved measurement of intrapl...

  6. Global Carriers’ Governance and Business Scope

    Directory of Open Access Journals (Sweden)

    Taylor Tae Hwee Lee

    2016-09-01

    Full Text Available Recent structural changes to the shipping industry triggered severe liquidity risks for not only small and medium-sized shipping lines but also global lines. Despite a severe downturn in the industry, a few lines have shown stable performance their finances. This study thus raises two research questions. Why do a few shipping lines maintain stable financial performance (FP? How much does the governance feature (GVF and the business scope (BSC influence FP? To answer these questions, this research uses regression analysis (RA to verify the relationships among the variables, GVF, BSC, and FP. The result of the RA showed a positive relationship between BSC and FP, but slight relationship between BSC and GVF and between knowledge and FP.

  7. Hardware Support for Safety-critical Java Scope Checks

    DEFF Research Database (Denmark)

    Rios Rivas, Juan Ricardo; Schoeberl, Martin

    2012-01-01

    Memory management in Safety-Critical Java (SCJ) is based on time bounded, non garbage collected scoped memory regions used to store temporary objects. Scoped memory regions may have different life times during the execution of a program and hence, to avoid leaving dangling pointers, it is necessary...... between threads and any other scoped region is thread private. In this paper we present how, due to this simplified model, a single scope nesting level can be used to check the legality of every reference assignment. We also show that with simple hardware extensions a processor can see some improvement...... in terms of execution time for applications where cross-scope references are frequent. Our proposal was implemented and tested on the Java Optimized Processor (JOP)....

  8. EarthScope's Transportable Array in Alaska

    Science.gov (United States)

    Busby, R. W.; Woodward, R.; Hafner, K.

    2013-12-01

    Since 2003, EarthScope has been installing a network of seismometers, known as the Transportable Array-across the continental United States and southern Canada. The station deployments will be completed in the Conterminous US in the fall of 2013. Beginning in October, 2013, and continuing for 5 years, EarthScope's Transportable Array plans to create a grid of seismic sensors in approximately 300 locations In Alaska and Western Canada. The proposed station grid is 85 km, and target locations will supplement or enhance existing seismic stations operating in Alaska. When possible, they will also be co-located with existing GPS stations constructed by the Plate Boundary Observatory. We review the siting plans for stations, the progress towards reconnaissance and permitting, and detail the engineering concept of the stations. In order to be able to determine the required site conditions and descriptions of installation methods to the permitting agencies, the National Science Foundation (NSF) has been supporting exploratory work on seismic station design, sensor emplacement and communication concepts appropriate for the challenging high-latitude environment that is proposed for deployment. IRIS has installed several experimental stations to evaluate different sensor emplacement schemes both in Alaska and the lower-48 U.S. The goal of these tests is to maintain or enhance a station's noise performance while minimizing its footprint and the equipment, materials, and overall expense required for its construction. Motivating this approach are recent developments in posthole broadband seismometer design and the unique conditions for operating in Alaska, where most areas are only accessible by small plane or helicopter, and permafrost underlies much of the region. IRIS has experimented with different portable drills and drilling techniques to create shallow holes (1-5M) in permafrost and rock outcrops. Seasonal changes can affect the performance of seismometers in different

  9. Defining food literacy: A scoping review.

    Science.gov (United States)

    Truman, Emily; Lane, Daniel; Elliott, Charlene

    2017-09-01

    The term "food literacy" describes the idea of proficiency in food related skills and knowledge. This prevalent term is broadly applied, although its core elements vary from initiative to initiative. In light of its ubiquitous use-but varying definitions-this article establishes the scope of food literacy research by identifying all articles that define 'food literacy', analysing its key conceptualizations, and reporting outcomes/measures of this concept. A scoping review was conducted to identify all articles (academic and grey literature) using the term "food literacy". Databases included Medline, Pubmed, Embase, CAB Abstracts, CINAHL, Scopus, JSTOR, and Web of Science, and Google Scholar. Of 1049 abstracts, 67 studies were included. From these, data was extracted on country of origin, study type (methodological approach), primary target population, and the primary outcomes relating to food literacy. The majority of definitions of food literacy emphasize the acquisition of critical knowledge (information and understanding) (55%) over functional knowledge (skills, abilities and choices) (8%), although some incorporate both (37%). Thematic analysis of 38 novel definitions of food literacy reveals the prevalence of six themes: skills and behaviours, food/health choices, culture, knowledge, emotions, and food systems. Study outcomes largely focus on knowledge generating measures, with very few focusing on health related outcome measures. Current definitions of food literacy incorporate components of six key themes or domains and attributes of both critical and functional knowledge. Despite this broad definition of the term, most studies aiming to improve food literacy focus on knowledge related outcomes. Few articles address health outcomes, leaving an important gap (and opportunity) for future research in this field. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Scoping Review of the Zika Virus Literature.

    Directory of Open Access Journals (Sweden)

    Lisa A Waddell

    Full Text Available The global primary literature on Zika virus (ZIKV (n = 233 studies and reports, up to March 1, 2016 has been compiled using a scoping review methodology to systematically identify and characterise the literature underpinning this broad topic using methods that are documented, updateable and reproducible. Our results indicate that more than half the primary literature on ZIKV has been published since 2011. The articles mainly covered three topic categories: epidemiology of ZIKV (surveillance and outbreak investigations 56.6% (132/233, pathogenesis of ZIKV (case symptoms/ outcomes and diagnosis 38.2% (89/233 and ZIKV studies (molecular characterisation and in vitro evaluation of the virus 18.5% (43/233. There has been little reported in the primary literature on ZIKV vectors (12/233, surveillance for ZIKV (13/233, diagnostic tests (12/233 and transmission (10/233. Three papers reported on ZIKV prevention/control strategies, one investigated knowledge and attitudes of health professionals and two vector mapping studies were reported. The majority of studies used observational study designs, 89.7% (209/233, of which 62/233 were case studies or case series, while fewer (24/233 used experimental study designs. Several knowledge gaps were identified by this review with respect to ZIKV epidemiology, the importance of potential non-human primates and other hosts in the transmission cycle, the burden of disease in humans, and complications related to human infection with ZIKV. Historically there has been little research on ZIKV; however, given its current spread through Australasia and the Americas, research resources are now being allocated to close many of the knowledge gaps identified in this scoping review. Future updates of this project will probably demonstrate enhanced evidence and understanding of ZIKV and its impact on public health.

  11. Scoping Review of the Zika Virus Literature.

    Science.gov (United States)

    Waddell, Lisa A; Greig, Judy D

    2016-01-01

    The global primary literature on Zika virus (ZIKV) (n = 233 studies and reports, up to March 1, 2016) has been compiled using a scoping review methodology to systematically identify and characterise the literature underpinning this broad topic using methods that are documented, updateable and reproducible. Our results indicate that more than half the primary literature on ZIKV has been published since 2011. The articles mainly covered three topic categories: epidemiology of ZIKV (surveillance and outbreak investigations) 56.6% (132/233), pathogenesis of ZIKV (case symptoms/ outcomes and diagnosis) 38.2% (89/233) and ZIKV studies (molecular characterisation and in vitro evaluation of the virus) 18.5% (43/233). There has been little reported in the primary literature on ZIKV vectors (12/233), surveillance for ZIKV (13/233), diagnostic tests (12/233) and transmission (10/233). Three papers reported on ZIKV prevention/control strategies, one investigated knowledge and attitudes of health professionals and two vector mapping studies were reported. The majority of studies used observational study designs, 89.7% (209/233), of which 62/233 were case studies or case series, while fewer (24/233) used experimental study designs. Several knowledge gaps were identified by this review with respect to ZIKV epidemiology, the importance of potential non-human primates and other hosts in the transmission cycle, the burden of disease in humans, and complications related to human infection with ZIKV. Historically there has been little research on ZIKV; however, given its current spread through Australasia and the Americas, research resources are now being allocated to close many of the knowledge gaps identified in this scoping review. Future updates of this project will probably demonstrate enhanced evidence and understanding of ZIKV and its impact on public health.

  12. Scoping Review of the Zika Virus Literature

    Science.gov (United States)

    2016-01-01

    The global primary literature on Zika virus (ZIKV) (n = 233 studies and reports, up to March 1, 2016) has been compiled using a scoping review methodology to systematically identify and characterise the literature underpinning this broad topic using methods that are documented, updateable and reproducible. Our results indicate that more than half the primary literature on ZIKV has been published since 2011. The articles mainly covered three topic categories: epidemiology of ZIKV (surveillance and outbreak investigations) 56.6% (132/233), pathogenesis of ZIKV (case symptoms/ outcomes and diagnosis) 38.2% (89/233) and ZIKV studies (molecular characterisation and in vitro evaluation of the virus) 18.5% (43/233). There has been little reported in the primary literature on ZIKV vectors (12/233), surveillance for ZIKV (13/233), diagnostic tests (12/233) and transmission (10/233). Three papers reported on ZIKV prevention/control strategies, one investigated knowledge and attitudes of health professionals and two vector mapping studies were reported. The majority of studies used observational study designs, 89.7% (209/233), of which 62/233 were case studies or case series, while fewer (24/233) used experimental study designs. Several knowledge gaps were identified by this review with respect to ZIKV epidemiology, the importance of potential non-human primates and other hosts in the transmission cycle, the burden of disease in humans, and complications related to human infection with ZIKV. Historically there has been little research on ZIKV; however, given its current spread through Australasia and the Americas, research resources are now being allocated to close many of the knowledge gaps identified in this scoping review. Future updates of this project will probably demonstrate enhanced evidence and understanding of ZIKV and its impact on public health. PMID:27244249

  13. A test of reactive scope: Reducing reactive scope causes delayed wound healing.

    Science.gov (United States)

    DuRant, S E; Arciniega, M L; Bauer, C M; Romero, L M

    2016-09-15

    Reactive scope predicts that all animals have an adaptive ability to respond to stressors in their environment, termed reactive homeostasis, and that only when an animal's response to stressful stimuli exceeds a certain threshold (homeostatic overload) will stress have pathological effects. While this framework has successfully helped interpret effects of stressors on wildlife, no study has designed an experiment to directly test this framework. This study was designed to expose house sparrows (Passer domesticus) to treatments that would result in varying ranges of reactive homeostasis during chronic stress, which based on the reactive scope model should cause birds with the lowest reactive homeostasis range to exhibit signs of pathology during a subsequent challenge. To modulate the reactive homeostasis range, we altered allostatic load of birds by exposing them to chronic stress while either elevating, blocking, or not manipulating corticosterone. After concluding chronic stress treatments, birds were exposed to the subsequent challenge of a superficial wound. Individuals treated with corticosterone during chronic stress (high allostatic load) experienced the most pathology, including both weight loss and slower wound healing. Unmanipulated birds (medium allostatic load) also experienced weight loss but had normal healing rates, while birds with blocked corticosterone (low allostatic load) had minimal weight loss and normal healing rates. Our results indicate that increased allostatic load reduces the reactive homeostasis range, thereby causing individuals to cross the homeostatic overload threshold sooner, and thus support the reactive scope framework.

  14. The Impact of Consumer Knowledge Bias on Narrow-Scope Trust, Broad-Scope Trust, and Relationship Satisfaction

    DEFF Research Database (Denmark)

    Hansen, Torben; Grønholdt, Lars; Josiassen, Alexander

    2016-01-01

    This study investigates how consumer knowledge bias - defined as knowledge over/underconfidence (O/U) - influences two types of trust (broad-scope trust and narrow-scope trust) and consumer relationship satisfaction. Based on a survey comprising 756 mutual fund investors, the contribution of this...

  15. A global attentional scope setting prioritizes faces for conscious detection.

    Science.gov (United States)

    Sun, Sol Z; Cant, Jonathan S; Ferber, Susanne

    2016-01-01

    The scope of visual attention is known to affect conscious object perception, with recent studies showing that a global attentional scope boosts holistic face processing, relative to a local scope. Here we show that attentional scope settings can also modulate the availability of information for conscious visual awareness. In an initial experiment, we show that adopting a global attentional scope accelerates conscious detection of initially invisible faces, presented under continuous flash suppression (CFS). Furthermore, face detection time was not modulated by attentional scope in a nonrivalrous control condition, which emulated the experience of CFS without inducing binocular rivalry. In a follow-up experiment, we report an exact replication of the original effect, as well as data suggesting that this effect is specific to upright faces, and is abolished when using both inverted faces and images of houses in an otherwise identical task. Thus, attentional scope settings can modulate the availability of information to conscious awareness, fundamentally altering the contents of our subjective visual experience.

  16. Cross-linguistic scope ambiguity: When two systems meet

    Directory of Open Access Journals (Sweden)

    Gregory Scontras

    2017-04-01

    Full Text Available Accurately recognizing and resolving ambiguity is a hallmark of linguistic ability. English is a language with scope ambiguities in doubly-quantified sentences like 'A shark ate every pirate'; this sentence can either describe a scenario with a single shark eating all of the pirates, or a scenario with many sharks—a potentially-different one eating each pirate. In Mandarin Chinese, the corresponding sentence is unambiguous, as it can only describe the single-shark scenario. We present experimental evidence to this effect, comparing native speakers of English with native speakers of Mandarin in their interpretations of doubly-quantified sentences. Having demonstrated the difference between these two languages in their ability for inverse scope interpretations, we then probe the robustness of the grammar of scope by extending our experiments to English-dominant adult heritage speakers of Mandarin. Like native speakers of Mandarin, heritage Mandarin speakers lack inverse scope in Mandarin. Crucially, these speakers also lack inverse scope in English, their dominant language in adulthood. We interpret these results as evidence for the pressure to simplify the grammar of scope, decreasing ambiguity when possible. In other words, when two systems meet—as in the case of heritage speakers—the simpler system prevails. This article is part of the special collection: Quantifier Scope

  17. Digital DNA of economy of scale and scope

    OpenAIRE

    Ledenyov, Dimitri O.; Ledenyov, Viktor O.

    2016-01-01

    The research article aims to create a general fundamental theory on the Digital DNA of the modern digital creative economy of the scale and scope. In the frames of our theory, we define the Digital DNA of the modern digital creative economy of the scale and scope, making the following theoretical assumptions: 1) Digital DNA exists in the modern digital creative economy of the scale and scope; 2) Digital DNA consists of a chain of the knowledge with all the information on the modern digital cr...

  18. The optical characteristics of aiming scopes in archery.

    Science.gov (United States)

    Long, W F; Haywood, K M

    1990-10-01

    Technical advancements in target archery have been extended to widespread use of "scopes" which magnify the target. In fact, these optical devices are simple converging lenses used at an arm's length from the eye. They produce a magnified image, but it is an image that suffers from significant dioptric blur, diminished somewhat by use of a peep sight in the bowstring which functions as an aperture stop. Visual acuities were taken with these scopes and, as might be expected, it was found that subjects saw no better with them. With the highest power scopes, acuity actually decreased. Experienced archers did slightly better with these aids than those with no archery experience.

  19. AuScope VLBI Project and Hobart 26-m Antenna

    Science.gov (United States)

    Lovell, Jim; Dickey, John; Reid, Brett; McCallum, Jamie; Shabala, Stas; Watson, Christopher; Ellingsen, Simon; Memin, Anthony

    2013-01-01

    This is a report on the activities carried out at the three AuScope VLBI observatories and the Hobart 26-m antenna. In 2012 the three AuScope 12-m antennas at Hobart (Hb), Katherine (Ke), and Yarragadee (Yg) completed their first full year of operations as an array. The Hobart 26-m antenna (Ho) continued to make a contribution to IVS, providing overlap with the Hb time series. In total the AuScope antennas and the Hobart 26 m observed for 146 antenna days in 2012. In this report we also briefly highlight our research activities during 2012 and our plans for 2013.

  20. Cementitious waste option scoping study report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, A.E.; Taylor, D.D.

    1998-02-01

    A Settlement Agreement between the Department of Energy (DOE) and the State of Idaho mandates that all high-level radioactive waste (HLW) now stored at the Idaho Chemical Processing Plant (ICPP) on the Idaho National Engineering and Environmental Laboratory (INEEL) will be treated so that it is ready to be moved out of Idaho for disposal by a target date of 2035. This study investigates the nonseparations Cementitious Waste Option (CWO) as a means to achieve this goal. Under this option all liquid sodium-bearing waste (SBW) and existing HLW calcine would be recalcined with sucrose, grouted, canisterized, and interim stored as a mixed-HLW for eventual preparation and shipment off-Site for disposal. The CWO waste would be transported to a Greater Confinement Disposal Facility (GCDF) located in the southwestern desert of the US on the Nevada Test Site (NTS). All transport preparation, shipment, and disposal facility activities are beyond the scope of this study. CWO waste processing, packaging, and interim storage would occur over a 5-year period between 2013 and 2017. Waste transport and disposal would occur during the same time period.

  1. Magnetotactic bacteria and magnetosomes - Scope and challenges.

    Science.gov (United States)

    Jacob, Jobin John; Suthindhiran, K

    2016-11-01

    Geomagnetism aided navigation has been demonstrated by certain organisms which allows them to identify a particular location using magnetic field. This attractive technique to recognize the course was earlier exhibited in numerous animals, for example, birds, insects, reptiles, fishes and mammals. Magnetotactic bacteria (MTB) are one of the best examples for magnetoreception among microorganisms as the magnetic mineral functions as an internal magnet and aid the microbe to move towards the water columns in an oxic-anoxic interface (OAI). The ability of MTB to biomineralize the magnetic particles (magnetosomes) into uniform nano-sized, highly crystalline structure with uniform magnetic properties has made the bacteria an important topic of research. The superior properties of magnetosomes over chemically synthesized magnetic nanoparticles made it an attractive candidate for potential applications in microbiology, biophysics, biochemistry, nanotechnology and biomedicine. In this review article, the scope of MTB, magnetosomes and its challenges in research and industrial application have been discussed in brief. This article mainly focuses on the application based on the magnetotactic behaviour of MTB and magnetosomes in different areas of modern science.

  2. Probiotics: definition, scope and mechanisms of action.

    Science.gov (United States)

    Reid, Gregor

    2016-02-01

    For a subject area of science, medicine and commerce to be so recently defined and investigated, few can compare to probiotics for the controversy they have incited. Barely a paper is published without the use of a different definition, or challenging the most used one, or proposing a different nuance of it. The situation has become even more surreal with the European Food and Safety Authority banning the word probiotic for use on labels. The reiteration of the FAO/WHO definition by the world's leading group of probiotic experts, should provide relative consistency in the near future, but what are the causes of these aberrations? This review will discuss the rationale for the definition, and the scope of the subject area and why alternatives emerge. While mechanisms of action are not widely proven, in vitro and some in vivo experiments support several. Ultimately, the goal of any field or product is to be understood by lay people and experts alike. Probiotics have come a long way in 100 years since Metchnikoff and 10 years since their globalization, but their evolution is far from over.

  3. The Scope of Numeracy after Five Years

    Directory of Open Access Journals (Sweden)

    H.L. Vacher

    2013-01-01

    Full Text Available The purpose of this editorial is to provide an efficient way for readers and potential authors to see (a what type of papers are published in this journal and (b what subjects are appropriate. The editorial consists mainly of about a dozen pages of tables including live links to the papers’ access/abstract pages to facilitate easy browsing. In the first table, the 85 papers that have been published in the journal’s first five years are classified into: review papers; research papers; case studies; essays; book reviews; columns; and editorials about the journal. In the second table, the papers are inventoried into overlapping sets on: assessment; QL and writing; the construct of QL; focused QL courses and curricula; QL across the curriculum; QL centers; algebra and calculus education; statistics education; intersections with science and engineering; intersections with social sciences; financial numeracy; health numeracy; math anxiety; and cognition. Browsing these links confirms what we said in the first editorial: the scope of Numeracy is huge.

  4. Economies of scope in Danish primary care practices

    DEFF Research Database (Denmark)

    Kristensen, Troels; Rose Olsen, Kim

    2011-01-01

    Aim: We analyze total operating costs and activities in Danish General Practice units to assess whether there are unexploited economies of scope in the production of primary care services. Methods: We apply stochastic frontier analysis to derive cost functions and associated cost complementarities...... between GP services and overall economies of scope. Data: Cross-section data for a sample of 331 primary care practices with 1-8 GPs from the year 2006. This is a unique combined dataset consisting of survey and register data. Results: We find a trend towards cost complementarities between the production...... economies of scope in the production of GP services. Conclusions: Our preliminary results show that there were overall economies of scope associated with the joint production of a) standard consultations, b) email/phone consultations and c) home visits. Cost complementarities between standard consultations...

  5. 12 CFR 28.50 - Authority, purpose, and scope.

    Science.gov (United States)

    2010-01-01

    ... subpart implements the requirements of the International Lending Supervision Act of 1983 (12 U.S.C. 3901 et seq.), (c) Scope. This subpart requires national banks to establish reserves against the risks... banks when making international loans. ...

  6. 42 CFR 410.3 - Scope of benefits.

    Science.gov (United States)

    2010-10-01

    ... SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS General Provisions § 410.3 Scope of benefits. (a) Covered services. The SMI program helps pay for the following: (1) Medical and other health services such...

  7. 49 CFR 1180.0 - Scope and purpose.

    Science.gov (United States)

    2010-10-01

    ... OF TRANSPORTATION RULES OF PRACTICE RAILROAD ACQUISITION, CONTROL, MERGER, CONSOLIDATION PROJECT, TRACKAGE RIGHTS, AND LEASE PROCEDURES General Acquisition Procedures § 1180.0 Scope and purpose. (a... followed in control, merger, acquisition, lease, trackage rights, and any other consolidation...

  8. 14 CFR 1204.400 - Scope of subpart.

    Science.gov (United States)

    2010-01-01

    ... Business Policy § 1204.400 Scope of subpart. This subpart establishes NASA's small business policy and outlines the delegation of authority in implementing this policy as required by Federal law....

  9. Credit Suisse , Regulatory Immunity, and the Shrinking Scope of Antitrust

    OpenAIRE

    Keith Sharfman

    2007-01-01

    Credit Suisse has important implications for antitrust practice. The decision’s effect is to narrow the scope of antitrust law and to invite efforts by regulated industries to narrow it still further.

  10. 28 CFR 551.20 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... Birth Control, Pregnancy, Child Placement, and Abortion § 551.20 Purpose and scope. The Bureau of Prisons provides an inmate with medical and social services related to birth control, pregnancy, child...

  11. 16 CFR 1031.16 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION PARTICIPATION AND COMMISSION EMPLOYEE INVOLVEMENT IN VOLUNTARY STANDARDS ACTIVITIES Public Participation and Comment § 1031.16 Purpose and scope. (a) This subpart sets forth the Consumer Product Safety Commission's criteria...

  12. 16 CFR 1031.1 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION PARTICIPATION AND COMMISSION EMPLOYEE INVOLVEMENT IN VOLUNTARY STANDARDS ACTIVITIES General Policies § 1031.1 Purpose and scope. (a) This part 1031 sets forth the Consumer Product Safety Commission's guidelines and requirements...

  13. 16 CFR 1031.9 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION PARTICIPATION AND COMMISSION EMPLOYEE INVOLVEMENT IN VOLUNTARY STANDARDS ACTIVITIES Employee Involvement § 1031.9 Purpose and scope. (a) This subpart sets forth the Consumer Product Safety Commission's criteria and requirements...

  14. 48 CFR 36.300 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Two-Phase Design-Build Selection Procedures 36.300 Scope of subpart. This subpart prescribes policies and procedures for the use of the two-phase...

  15. Scope of Collections Statement Ohio River Islands National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Scope of Collections Statement serves to define the holdings, present and future, of museum property that contributes directly to the mission of Ohio River...

  16. 48 CFR 4.500 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... MATTERS Electronic Commerce in Contracting 4.500 Scope of subpart. This subpart provides policy and procedures for the establishment and use of electronic commerce in Federal acquisition as required by...

  17. 28 CFR 549.60 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... Hunger Strikes, Inmate § 549.60 Purpose and scope. The Bureau of Prisons provides guidelines for the medical and administrative management of inmates who engage in hunger strikes. It is the responsibility...

  18. Use of YouScope to implement systematic microscopy protocols.

    Science.gov (United States)

    Lang, Moritz; Rudolf, Fabian; Stelling, Jörg

    2012-04-01

    Complex microscopy protocols, e.g., to dynamically track multiple signals in living cells under different conditions, are becoming more common. However, the implementation of complex protocols on modern, motorized microscopes often requires their reformulation into low-level machine language. This recoding is a time-consuming and error-prone task that often requires advanced programming skills. This unit describes how to use the high level, open-source microscope control platform YouScope to implement complex measurement protocols. Three protocols detail how to install and configure YouScope on a motorized microscope, how to use YouScope to quickly assess the quality of a sample, and how to set up imaging protocols for cells in a microplate. In addition to these protocols, descriptions are given for the use of various other tools YouScope provides to successfully accomplish various microscopy tasks.

  19. 48 CFR 919.7001 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... BUSINESS PROGRAMS The Department of Energy Mentor-Protege Program 919.7001 Scope of subpart. The Department of Energy (DOE) Mentor-Protege Program is designed to encourage DOE prime contractors to assist...

  20. 50 CFR 654.1 - Purpose and scope.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF COMMERCE STONE CRAB FISHERY OF THE GULF OF MEXICO General Measures § 654.1 Purpose and scope... of the Gulf of Mexico, prepared by the Gulf of Mexico Fishery Management Council under the...

  1. 48 CFR 2110.7000 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... GROUP LIFE INSURANCE FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING SPECIFICATIONS, STANDARDS, AND OTHER PURCHASE DESCRIPTIONS Contract Specifications 2110.7000 Scope of subpart. This subpart prescribes mandatory specifications for performance under FEGLI Program contracts....

  2. Meta-Research: Broadening the Scope of PLOS Biology.

    Science.gov (United States)

    Kousta, Stavroula; Ferguson, Christine; Ganley, Emma

    2016-01-01

    In growing recognition of the importance of how scientific research is designed, performed, communicated, and evaluated, PLOS Biology announces a broadening of its scope to cover meta-research articles.

  3. 45 CFR 63.16 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... OFFICE OF THE ASSISTANT SECRETARY FOR PLANNING AND EVALUATION Financial Provisions § 63.16 Scope of subpart. This subpart sets forth supplemental financial provisions which apply to all grants awarded...

  4. 32 CFR 537.16 - Scope for maritime claims.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Scope for maritime claims. 537.16 Section 537.16 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY CLAIMS AND ACCOUNTS CLAIMS ON BEHALF OF THE UNITED STATES § 537.16 Scope for maritime claims. The Army Maritime Claims Settlement Act (10 U.S.C. 4803-4804) applies...

  5. Spread Too Thin: Uncertainty Shocks and Diseconomies of Scope

    OpenAIRE

    Gabriel Natividad; Olav Sorenson

    2011-01-01

    Although many streams of literature have recognized that firms with broader scope often underperform those with greater focus, relatively little research has examined the mechanisms that might account for these diseconomies of scope. One potential mechanism is that uncertainty shocks -- events or short-term periods that upset the normal course of business -- place unusual demands on the limited attention of managers. When managers of larger, more diverse firms allocate their time and organiza...

  6. Knowledge Syntheses in Medical Education: Demystifying Scoping Reviews.

    Science.gov (United States)

    Thomas, Aliki; Lubarsky, Stuart; Durning, Steven J; Young, Meredith E

    2017-02-01

    An unprecedented rise in health professions education (HPE) research has led to increasing attention and interest in knowledge syntheses. There are many different types of knowledge syntheses in common use, including systematic reviews, meta-ethnography, rapid reviews, narrative reviews, and realist reviews. In this Perspective, the authors examine the nature, purpose, value, and appropriate use of one particular method: scoping reviews. Scoping reviews are iterative and flexible and can serve multiple main purposes: to examine the extent, range, and nature of research activity in a given field; to determine the value and appropriateness of undertaking a full systematic review; to summarize and disseminate research findings; and to identify research gaps in the existing literature. Despite the advantages of this methodology, there are concerns that it is a less rigorous and defensible means to synthesize HPE literature. Drawing from published research and from their collective experience with this methodology, the authors present a brief description of scoping reviews, explore the advantages and disadvantages of scoping reviews in the context of HPE, and offer lessons learned and suggestions for colleagues who are considering conducting scoping reviews. Examples of published scoping reviews are provided to illustrate the steps involved in the methodology.

  7. Scoping review report: obesity in older adults.

    Science.gov (United States)

    Decaria, J E; Sharp, C; Petrella, R J

    2012-09-01

    Obesity is associated with an increased risk for early death, heart disease and stroke, disability and several other comorbidities. Although there is concern about the potential burden on health-care services with the aging demographic and the increasing trend of obesity prevalence in older adults, evidence on which to base management strategies is conflicting for various reasons. The analytic framework for this review is based on a scoping review methodology, and was conducted to examine what is known about the diagnosis, treatment and management of obesity in older adults. A total of 492 relevant research articles were identified using PubMed, Scirus, EBSCO, Clinicaltrials.gov, Cochrane Reviews and Google Scholar. The findings of this review indicate that the current WHO (World Health Organization)-recommended body mass index, waist circumference and waist-to-hip ratio obesity thresholds for the general adult population may not be appropriate for older adults. Alternatively, weight change or physical fitness may be more useful measures of mortality and health risk in obese older adults. Furthermore, although obesity in older adults is associated with several disorders that increase functional disability, epidemiological evidence suggests that obesity is protective against mortality in seniors. Consequently, the trend toward increasing prevalence of obesity in older adults will lead to an increase in unhealthy life years and health-care costs. The findings from this review also suggest that treatment strategies for obese older adults should focus on maintaining body weight and improving physical fitness and function rather than weight loss, and that a combination of aerobic and resistance exercise appears to be the most effective strategy. In conclusion, this review demonstrates the need for more research to clarify the definition of obesity in older adults, to establish criteria for evaluating when to treat older adults for obesity, and to develop effective

  8. Developing Authentic Research Experiences Using EarthScope Data

    Science.gov (United States)

    Hall-Wallace, M. K.

    2003-12-01

    EarthScope, a decade-long experiment to understand the formation, structure, and evolution of the North American continent, will carry-out active investigations in nearly every county in the US. The excitement of a huge science experiment in one's own backyard piques interest, but teachers need resources and professional development experiences to capitalize upon this excitement and create opportunities for their students' learning. The EarthScope Education and Outreach Network will provide the interface to make EarthScope science, and the advanced technology and modern approaches used to understand Earth, relevant and beneficial to K-16 educators vested in advancing Earth science education. Three obstacles must be overcome for success in carrying out authentic EarthScope research in the classroom. First, scientists and teachers must work together to identify relevant and developmentally appropriate research questions for the target audience. Second, teachers will need professional development experiences that engage them in authentic research and that provide support for introducing a similar research experience in their own classroom. Third, the outcome of the research experience must have value to the scientist, teacher and student to motivate sustained participation by all. The dense array of seismometers being deployed in the USArray component of EarthScope will permit students and the public to see first-hand Earth's dynamic response to both human and natural events in their hometown and around the country. Targeted local experiments will make EarthScope's scientific investigations and discoveries relevant for educational efforts on a region-by-region basis. Combining the real-time seismic data streams from USArray with data and instrumentation from the growing US Educational Seismic Network (USESN) opens up endless possibilities for student-centered research. In this paper, I will discuss the lessons learned from eight years of leading a high school

  9. Automated scoping methodology for liquid metal natural circulation small reactor

    Energy Technology Data Exchange (ETDEWEB)

    Son, Hyung M.; Suh, Kune Y., E-mail: kysuh@snu.ac.kr

    2014-07-01

    Highlights: • Automated scoping methodology for natural circulation small modular reactor is developed. • In-house code is developed to carry out system analysis and core geometry generation during scoping. • Adjustment relations are obtained to correct the critical core geometry out of diffusion theory. • Optimized design specification is found using objective function value. • Convex hull volume is utilized to quantify the impact of different constraints on the scope range. - Abstract: A novel scoping method is proposed that can automatically generate design variable range of the natural circulation driven liquid metal cooled small reactor. From performance requirements based upon Generation IV system roadmap, appropriate structure materials are selected and engineering constraints are compiled based upon literature. Utilizing ASME codes and standards, appropriate geometric sizing criteria on constituting components are developed to ensure integrity of the system during its lifetime. In-house one dimensional thermo-hydraulic system analysis code is developed based upon momentum integral model and finite element methods to deal with non-uniform descritization of temperature nodes for convection and thermal diffusion equation of liquid metal coolant. In order to quickly generate critical core dimensions out of given unit cell information, an adjustment relation that relates the critical geometry estimated from one-group diffusion and that from MCNP code is constructed and utilized throughout the process. For the selected unit cell dimension ranges, burnup calculations are carried out to check the cores can generate energy over the reactor lifetime. Utilizing random method, sizing criteria, and in-house analysis codes, an automated scoping methodology is developed. The methodology is applied to nitride fueled integral type lead cooled natural circulation reactor concept to generate design scopes which satisfies given constraints. Three dimensional convex

  10. USArray Siting Outreach: Telling the EarthScope Story

    Science.gov (United States)

    Dorr, P. M.; Taber, J. J.; McQuillan, P.; Busby, R. W.; Woodward, R.

    2013-12-01

    USArray has engaged in a variety of activities that involve students in and inform the general public about EarthScope. Examples include the highly successful Transportable Array Student Siting Program that employed students and faculty from colleges and universities in the identification of sites for future Transportable Array stations in their region, and a range of informal education and media opportunities where information about EarthScope and its discoveries are shared with educators and the public. During the course of eight summers, more than 135 students from about 55 institutions conducted site reconnaissance for nearly 1375 sites from the West Coast to the East Coast, and from the Gulf of Mexico to the Great Lakes and southern Canada. While telling the EarthScope story, students who participated in the program increased their professional skills and deepened their personal growth. Other students had opportunities to engage in EarthScope-related research as part of the Research Experiences for Undergraduates program. Several EarthScope-focused outreach products for the public and educational audiences have been developed including Ground Motion Visualizations, EarthScope-centric and regional content sets for the IRIS Active Earth Monitor (AEM), and animations of earth processes. A kiosk loan program has helped to broadly disseminate the AEM displays. There have also been articles published in university, local and regional newspapers; stories appearing in national and international print and broadcast media; and documentaries produced by some of the world's most respected scientific and educational production companies that have included a segment about EarthScope and the Transportable Array. Over the next five years, USArray will be deploying and operating Transportable Array stations in Alaska and western Canada. This challenging environment will offer new opportunities to connect with communities throughout the region including native populations.

  11. Scope Complexity Options Risks Excursions (SCORE) Factor Mathematical Description.

    Energy Technology Data Exchange (ETDEWEB)

    Gearhart, Jared Lee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Samberson, Jonell Nicole [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Shettigar, Subhasini [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jungels, John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Welch, Kimberly M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Dean A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-03-01

    The purpose of the Scope, Complexity, Options, Risks, Excursions (SCORE) model is to estimate the relative complexity of design variants of future warhead options, resulting in scores. SCORE factors extend this capability by providing estimates of complexity relative to a base system (i.e., all design options are normalized to one weapon system). First, a clearly defined set of scope elements for a warhead option is established. The complexity of each scope element is estimated by Subject Matter Experts (SMEs), including a level of uncertainty, relative to a specific reference system. When determining factors, complexity estimates for a scope element can be directly tied to the base system or chained together via comparable scope elements in a string of reference systems that ends with the base system. The SCORE analysis process is a growing multi-organizational Nuclear Security Enterprise (NSE) effort, under the management of the NA-12 led Enterprise Modeling and Analysis Consortium (EMAC). Historically, it has provided the data elicitation, integration, and computation needed to support the out-year Life Extension Program (LEP) cost estimates included in the Stockpile Stewardship Management Plan (SSMP).

  12. Visualizing Data from EarthScope's USArray

    Science.gov (United States)

    Woodward, R.; Frassetto, A.; Adinolfi, A.

    2012-12-01

    The EarthScope USArray program has generated a large volume of data from across the North American continent. The Transportable Array (TA) component of USArray has deployed over 400 seismic stations in a grid with 70 km spacing between stations. The TA has rolled the array across the contiguous US states over a ten-year period, and will have occupied over 1600 distinct sites from the Pacific Ocean to the Atlantic Ocean by the end of 2013. All stations transmit multiple channels of 40 samples per second data continuously, in near real time. Each station records and transmits seismic, barometric pressure, and infrasound data, as well as various state-of-health data streams. All data are immediately open and unrestricted. The TA provides a unique tool for visualizing large-scale seismic wave phenomena. The power of this tool is particularly apparent when displaying simultaneous signals from all stations as a function of time, as well as rendering multiple channels of data from each station. In this situation it is challenging to convey the 3D motion at each station as well as the aggregate 3D motion across the entire set of 400 stations. Creating movies of the data becomes essential to illustrate the time dependence of the observations. Typically the rendering of such movies requires the use of programming language that is suitable for both data analysis and graphics, as it is essential to explore different data pre-processing strategies (often filtering, but also including other pre-processing steps). Different visualization strategies provide a means for dealing with the very large volume of data generated by the TA. Typical data review strategies include a survey mode to scan large volumes of data for signals of interest, or zooming in on fine features using combinations of specialized data processing and frame-by-frame time-steps, or going back and forth between the two modes. The data visualizations are continuously evolving to explore new ideas. The movie

  13. Creating the Individual Scope of Practice (I-SOP) scale.

    Science.gov (United States)

    O'Neill, Thomas; Peabody, Michael R; Blackburn, Brenna E; Peterson, Lars E

    2014-01-01

    Research indicates that the scope of practice for primary care physicians has been shrinking (Tong, Makaroff, Xierali, Parhat, Puffer, Newton, et al., 2012; Xierali, Puffer, Tong, Bazemore, and Green, 2012; and Bazemore, Makaroff, Puffer, Parhat, Phillips, Xierali, et al., 2012) despite research showing that areas with robust primary care services have better population health outcomes at lower costs (Starfield, Shi, and Macinko, 2005). Examining issues related to the scope of practice for primary care physicians has wide-ranging implications for both patient health outcomes and related healthcare costs. This article describes the development and use of a scale intended to measure the breath of the individual physician's scope of practice using 22 self-reported, dichotomous indicators obtained from a physician survey.

  14. Scale and scope economies among health maintenance organizations.

    Science.gov (United States)

    Wholey, D; Feldman, R; Christianson, J B; Engberg, J

    1996-12-01

    We examine scale and scope economics among Group and IPA Health Maintenance Organizations (HMOs) over the period 1988 to 1991 using a national sample of HMOs. We allow for the multiproduct nature of HMO production by estimating the cost of producing a member month of non-Medicare and Medicare coverage, and we examine the effect of HMO market structure on costs. We find that HMOs benefit from scale economies. There are scope diseconomies associated with providing both non-Medicare and Medicare products. Group HMOs in more competitive markets have lower costs but IPA costs are not affected by competition.

  15. The Scope of Gene Patent Protection and the TRIPS Agreement

    DEFF Research Database (Denmark)

    Sommer, Tine

    2007-01-01

    The Scope of Gene Patent Protection and the TRIPS Agreement - An Exclusively Nondiscriminatory Approach?   Gene patenting in Europe has provoked much debate both before and since the adoption of Directive 98/44/EC on the legal protection of biotechnological inventions. Some of the major points...... of discussion have been focused on the scope of protection (e.g. purpose-bound protection) and gene patents being subject to a specific DNA regime on patent rights. The Directive can be interpreted as favouring such a solution, but so far the European Commission has decided neither to support nor reject...

  16. Practical Limits to the Scope of Digital Preservation

    Directory of Open Access Journals (Sweden)

    Mike Kastellec

    2012-06-01

    Full Text Available This paper examines factors that limit the ability of institutions to digitally preserve the cultural heritage of the modern era. The author takes a wide-ranging approach to shed light on limitations to the scope of digital preservation.  The author finds that technological limitations to digital preservation have been addressed but still exist, and that non-technical aspects—access, selection, law, and finances—move into the foreground as technological limitations recede.  The author proposes a nested model of constraints to the scope of digital preservation and concludes that costs are digital preservation’s most pervasive limitation.

  17. The Impact of Consumer Knowledge Bias on Narrow-Scope Trust, Broad-Scope Trust, and Relationship Satisfaction

    DEFF Research Database (Denmark)

    Hansen, Torben; Grønholdt, Lars; Josiassen, Alexander

    2016-01-01

    This study investigates how consumer knowledge bias - defined as knowledge over/underconfidence (O/U) - influences two types of trust (broad-scope trust and narrow-scope trust) and consumer relationship satisfaction. Based on a survey comprising 756 mutual fund investors, the contribution...... is low compared to high. Notably, the study findings strongly suggest that marketing managers should carry out their relationship satisfaction and trust improvement efforts relative to the combination of customers‟ subjective and objective knowledge....... of this study to the marketing literature is twofold. First, taking a marketing relationship approach this study suggests and demonstrates that knowledge O/U positively influences relationship satisfaction and narrow-scope trust such that the more knowledge O/U a customer becomes, the higher/lower the level...

  18. Double-Scope Peroral Endoscopic Myotomy (POEM) for Esophageal Achalasia: The First Trial of a New Double-Scope POEM.

    Science.gov (United States)

    Hong, Hee Jin; Song, Ga Won; Ko, Weon Jin; Kim, Won Hee; Hahm, Ki Baik; Hong, Sung Pyo; Cho, Joo Young

    2016-07-01

    With the accumulation of clinical trials demonstrating its efficacy and safety, peroral endoscopic myotomy (POEM) has emerged as a less invasive treatment option for esophageal achalasia compared with laparoscopic Heller myotomy. However, the difficulty in determining the exact extent of myotomy, a critical factor associated with the success and safety of the procedure, remains a limitation. Although the various endoscopic landmarks and ancillary techniques have been applied, none of these has been proven sufficient. As a solution for this limitation, the double-scope POEM technique with a second endoscope to assure the exact length of the submucosal tunnel has been applied since 2014. Before double-scope POEM was introduced, the second endoscope was applied only to confirm the accuracy of the procedure. In the present study, we performed double-scope POEM in the treatment of esophageal achalasia through a novel procedure of simultaneous application of the second endoscope to assist in the conventional POEM procedure.

  19. Scoping of flood hazard mapping needs for Somerset County, Maine

    Science.gov (United States)

    Dudley, Robert W.; Schalk, Charles W.

    2006-01-01

    This report was prepared by the U.S. Geological Survey (USGS) Maine Water Science Center as the deliverable for scoping of flood hazard mapping needs for Somerset County, Maine, under Federal Emergency Management Agency (FEMA) Inter-Agency Agreement Number HSFE01-05-X-0018. This section of the report explains the objective of the task and the purpose of the report. The Federal Emergency Management Agency (FEMA) developed a plan in 1997 to modernize the FEMA flood mapping program. FEMA flood maps delineate flood hazard areas in support of the National Flood Insurance Program (NFIP). FEMA's plan outlined the steps necessary to update FEMA's flood maps for the nation to a seamless digital format and streamline FEMA's operations in raising public awareness of the importance of the maps and responding to requests to revise them. The modernization of flood maps involves conversion of existing information to digital format and integration of improved flood hazard data as needed. To determine flood mapping modernization needs, FEMA has established specific scoping activities to be done on a county-by-county basis for identifying and prioritizing requisite flood-mapping activities for map modernization. The U.S. Geological Survey (USGS), in cooperation with FEMA and the Maine State Planning Office Floodplain Management Program, began scoping work in 2005 for Somerset County. Scoping activities included assembling existing data and map needs information for communities in Somerset County (efforts were made to not duplicate those of pre-scoping completed in March 2005), documentation of data, contacts, community meetings, and prioritized mapping needs in a final scoping report (this document), and updating the Mapping Needs Update Support System (MNUSS) Database or its successor with information gathered during the scoping process. The average age of the FEMA floodplain maps in Somerset County, Maine is 18.1 years. Most of these studies were in the late 1970's to the mid 1980

  20. 46 CFR 53.01-5 - Scope (modifies HG-100).

    Science.gov (United States)

    2010-10-01

    ... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING HEATING BOILERS General Requirements § 53.01-5 Scope (modifies HG-100). (a) The regulations in this part apply to steam heating boilers, hot water boilers (which include hot water heating boilers and hot water supply...

  1. 7 CFR 271.1 - General purpose and scope.

    Science.gov (United States)

    2010-01-01

    ..., in part: Congress hereby finds that the limited food purchasing power of low-income households... households to obtain a more nutritious diet through normal channels of trade by increasing food purchasing power for all eligible households who apply for participation. (b) Scope of the regulations. Part 271...

  2. 48 CFR 25.400 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... PROGRAMS FOREIGN ACQUISITION Trade Agreements 25.400 Scope of subpart. (a) This subpart provides policies... of 1993 (19 U.S.C. 3301 note)); (ii) Chile FTA (the United States-Chile Free Trade Agreement, as approved by Congress in the United States-Chile Free Trade Agreement Implementation Act (Pub. L. 108-77...

  3. 12 CFR 204.1 - Authority, purpose and scope.

    Science.gov (United States)

    2010-01-01

    ....1 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RESERVE REQUIREMENTS OF DEPOSITORY INSTITUTIONS (REGULATION D) § 204.1 Authority, purpose and scope. (a) Authority... the Federal Reserve Act and of section 7 of the International Banking Act of 1978 (12 U.S.C. 3105). (b...

  4. 12 CFR 201.1 - Authority, purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... applies to United States branches and agencies of foreign banks that are subject to reserve requirements....1 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM EXTENSIONS OF CREDIT BY FEDERAL RESERVE BANKS (REGULATION A) § 201.1 Authority, purpose and scope. (a...

  5. 12 CFR 1102.300 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... and functions. Section 1102.303 describes the ASC's organization and methods of operation. Section... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Purpose and scope. 1102.300 Section 1102.300... does not apply to the Federal Financial Institutions Examination Council. Section 1102.301 sets...

  6. 50 CFR 17.2 - Scope of regulations.

    Science.gov (United States)

    2010-10-01

    ... Convention on International Trade in Endangered Species of Wild Fauna and Flora. The importation, exportation... PLANTS (CONTINUED) ENDANGERED AND THREATENED WILDLIFE AND PLANTS Introduction and General Provisions § 17.2 Scope of regulations. (a) The regulations of this part apply only to endangered and...

  7. 16 CFR 1616.65 - Policy scope of the standard.

    Science.gov (United States)

    2010-01-01

    ... advertise, promote, or sell as an item of children's sleepwear any item which a manufacturer, importer, or... STANDARD FOR THE FLAMMABILITY OF CHILDREN'S SLEEPWEAR: SIZES 7 THROUGH 14 (FF 5-74) Interpretations and Policies § 1616.65 Policy scope of the standard. (a) The Standard for the Flammability of...

  8. Economies of Scale and Scope in Australian Higher Education

    Science.gov (United States)

    Worthington, A. C.; Higgs, H.

    2011-01-01

    This paper estimates economies of scale and scope for 36 Australian universities using a multiple-input, multiple-output cost function over the period 1998-2006. The three inputs included in the analysis are full-time equivalent academic and non-academic staff and physical capital. The five outputs are undergraduate, postgraduate and PhD…

  9. Economies of scale and scope in mental health care

    NARCIS (Netherlands)

    Wilschut, J.A.; Van Hulst, B.L.; Blank, J.L.T.

    2012-01-01

    Economies of scale and scope are usually derived under the assumption that the set of production possibilities are shared by all firms in an industry irrespective of whether they specialize in a single output or not. Mental health care institutions in the Netherlands vary substantially in the scale

  10. Do Liberal Arts Colleges Exhibit Economies of Scale and Scope?

    Science.gov (United States)

    Koshal, Rajindar K.; Koshal, Manjulika

    2000-01-01

    Empirically estimates a multiple-product fixed total cost function and output relationship for 295 U.S. private liberal-arts colleges. Statistical results suggest that there are economies of scale and scope in higher education. Research at such colleges is not cost-effective. (Contains 31 references.) (MLH)

  11. 28 CFR 505.1 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Purpose and scope. 505.1 Section 505.1 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE GENERAL MANAGEMENT AND ADMINISTRATION COST... and collection of a fee to cover the cost of incarceration. The Director of the Bureau of Prisons...

  12. 48 CFR 1819.7301 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs 1819.7301 Scope of subpart. The Small Business Innovation Research (SBIR... of the Small Business Act codified at 15 U.S.C. 631, as amended, and the Small Business...

  13. 39 CFR 3030.2 - Scope and nature of complaints.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Scope and nature of complaints. 3030.2 Section 3030.2 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL RULES FOR COMPLAINTS General § 3030.2... if that person believes that the Postal Service is not operating in conformance with: (a) The...

  14. 13 CFR 306.1 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ...) Provide management and operational assistance; (7) Establish business outreach centers; (8) Disseminate... business. (c) EDA may identify specific training, research or technical assistance Projects it will fund... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Purpose and scope. 306.1...

  15. 12 CFR 604.410 - Scope of application.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Scope of application. 604.410 Section 604.410 Banks and Banking FARM CREDIT ADMINISTRATION ADMINISTRATIVE PROVISIONS FARM CREDIT ADMINISTRATION BOARD... not apply to conferences or other gatherings of employees of the Farm Credit Administration who...

  16. 24 CFR 3282.551 - Scope and purpose.

    Science.gov (United States)

    2010-04-01

    ..., PIAs and SAAs as part of the system of enforcement established under these regulations. Additional... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Scope and purpose. 3282.551 Section 3282.551 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued...

  17. 29 CFR 570.70 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Purpose and scope. 570.70 Section 570.70 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS CHILD LABOR... “provisions of section 12 relating to child labor shall apply to an employee below the age of 16 employed in...

  18. 29 CFR 510.2 - Purpose and scope of regulations.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Purpose and scope of regulations. 510.2 Section 510.2 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS IMPLEMENTATION OF THE MINIMUM WAGE PROVISIONS OF THE 1989 AMENDMENTS TO THE FAIR LABOR STANDARDS ACT IN PUERTO...

  19. 29 CFR 2570.96 - Scope of discovery.

    Science.gov (United States)

    2010-07-01

    ... section shall apply in lieu of 29 CFR 18.14. (a) A party may file a motion to conduct discovery with the... 29 Labor 9 2010-07-01 2010-07-01 false Scope of discovery. 2570.96 Section 2570.96 Labor... ADMINISTRATION AND ENFORCEMENT UNDER THE EMPLOYEE RETIREMENT INCOME SECURITY ACT OF 1974 PROCEDURAL...

  20. 13 CFR 303.1 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... PLANNING INVESTMENTS AND COMPREHENSIVE ECONOMIC DEVELOPMENT STRATEGIES § 303.1 Purpose and scope. The purpose of EDA Planning Investments is to provide support to Planning Organizations for the development, implementation, revision or replacement of Comprehensive Economic Development Strategies, and for related short...

  1. 42 CFR 424.70 - Basis and scope.

    Science.gov (United States)

    2010-10-01

    ... violates the conditions to which it agreed in accepting assignment from the individual; and (3) Specifies...) MEDICARE PROGRAM CONDITIONS FOR MEDICARE PAYMENT Limitations on Assignment and Reassignment of Claims § 424... services or a beneficiary. (b) Scope. This subpart— (1) Prohibits the assignment, reassignment, or...

  2. 36 CFR 251.80 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... scope. (a) This subpart provides a process by which those who hold or, in certain instances, those who apply for written authorizations to occupy and use National Forest System lands, may appeal a written...) The rules in this subpart seek to offer appellants a fair and deliberate process for appealing...

  3. 10 CFR 474.1 - Purpose and Scope.

    Science.gov (United States)

    2010-01-01

    ... PROGRAM; PETROLEUM-EQUIVALENT FUEL ECONOMY CALCULATION § 474.1 Purpose and Scope. This part contains procedures for calculating a value for the petroleum-equivalent fuel economy of electric vehicles, as required by 49 U.S.C. 32904(a)(2). The petroleum-equivalent fuel economy value is intended to be used...

  4. 41 CFR 101-1.100 - Scope of subpart.

    Science.gov (United States)

    2010-07-01

    ... Management Regulations System: its content, types, publication, authority, applicability, numbering... System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1-Regulation System § 101-1.100... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Scope of subpart....

  5. Agricultural pricing policy in Kenya : scope and impact

    NARCIS (Netherlands)

    Meilink, H.A.

    1985-01-01

    Reviews the findings of available studies and reports thought to be of relevance to policy makers. A discussion of the institutional framework, of criteria used in price-setting procedures, and of scope and objectives of the agricultural pricing policies is folowed by an examination of what these po

  6. 29 CFR 2570.166 - Scope of discovery.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Scope of discovery. 2570.166 Section 2570.166 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... impressions, conclusions, opinions, or legal theories of an attorney or other representatives of a party...

  7. 29 CFR 2570.66 - Scope of discovery.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Scope of discovery. 2570.66 Section 2570.66 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... impressions, conclusions, opinions, or legal theories of an attorney or other representatives of a party...

  8. 29 CFR 2570.136 - Scope of discovery.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Scope of discovery. 2570.136 Section 2570.136 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... impressions, conclusions, opinions, or legal theories of an attorney or other representatives of a party...

  9. 29 CFR 2570.116 - Scope of discovery.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Scope of discovery. 2570.116 Section 2570.116 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... impressions, conclusions, opinions, or legal theories of an attorney or other representatives of a party...

  10. 29 CFR 18.14 - Scope of discovery.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Scope of discovery. 18.14 Section 18.14 Labor Office of the Secretary of Labor RULES OF PRACTICE AND PROCEDURE FOR ADMINISTRATIVE HEARINGS BEFORE THE OFFICE OF..., conclusions, opinions, or legal theories of an attorney or other representative of a party concerning the...

  11. 29 CFR 2570.7 - Scope of discovery.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Scope of discovery. 2570.7 Section 2570.7 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR ADMINISTRATION... impressions, conclusions, opinions, or legal theories of an attorney or other representative of a party...

  12. 5 CFR 9901.104 - Scope of authority.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Scope of authority. 9901.104 Section 9901.104 Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS... with performance appraisal systems; (b) Chapter 51, dealing with General Schedule job...

  13. 42 CFR 407.1 - Basis and scope.

    Science.gov (United States)

    2010-10-01

    ... SUPPLEMENTARY MEDICAL INSURANCE (SMI) ENROLLMENT AND ENTITLEMENT General Provisions § 407.1 Basis and scope. (a) Statutory basis. The supplementary medical insurance (SMI) program is authorized by Part B of title XVIII of... pay the SMI premiums for, eligible individuals who are also eligible for cash assistance or...

  14. 16 CFR 1303.1 - Scope and application.

    Science.gov (United States)

    2010-01-01

    ... of the dried paint film (which paint and similar surface-coating materials are referred to hereafter... content of over 0.06 percent in paints and coatings to which children have access and that no feasible...-CONTAINING PAINT AND CERTAIN CONSUMER PRODUCTS BEARING LEAD-CONTAINING PAINT § 1303.1 Scope and application...

  15. A Definition of the Scope of Environmental Management.

    Science.gov (United States)

    Dreyfus, Daniel A.

    This report is a condensation of an unpublished paper by Daniel Dreyfus, a member of the professional staff of the Committee on Interior and Insular Affairs. Dreyfus develops a classification system of environmental management activities which has as its purpose to partially remove the present disagreement upon the scope of environmental…

  16. 5 CFR 890.1001 - Scope and purpose.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Scope and purpose. 890.1001 Section 890.1001 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Administrative Sanctions Imposed Against Health Care...

  17. 12 CFR 210.25 - Authority, purpose, and scope.

    Science.gov (United States)

    2010-01-01

    ... incorporated herein, shall not apply. (c) Operating Circulars. Each Federal Reserve Bank shall issue an... organization; (3) A foreign central bank; and (4) A department, agency, instrumentality, independent... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Authority, purpose, and scope. 210.25...

  18. The scope for policy reforms in rural microfinance

    OpenAIRE

    Sharma, Manohar

    2000-01-01

    This brief considers the scope for policy action in seven areas: (1) regulation of microfinance institutions, (2) provision of saving services, (3) product innovation, (4) organizational issues in microfinance, (5) poverty impact of microfinance, (6) agricultural finance, and (7) subsidy and sustainability issues.

  19. 5 CFR 293.101 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... RECORDS Basic Policies on Maintenance of Personnel Records § 293.101 Purpose and scope. (a) This subpart..., dissemination, and safeguarding of personnel records which the Office of Personnel Management requires agencies to maintain in the personnel management or personnel policy setting process. (b) Agencies in...

  20. 44 CFR 6.1 - Purpose and scope of part.

    Science.gov (United States)

    2010-10-01

    ... records maintained by the Federal Emergency Management Agency (FEMA) which are subject to the provision of...). These policies and procedures govern only those records as defined in § 6.2. Policies and procedures... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Purpose and scope of part....

  1. 42 CFR 485.601 - Basis and scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Basis and scope. 485.601 Section 485.601 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION CONDITIONS OF PARTICIPATION: SPECIALIZED PROVIDERS Conditions of...

  2. 42 CFR 485.50 - Basis and scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Basis and scope. 485.50 Section 485.50 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION CONDITIONS OF PARTICIPATION: SPECIALIZED PROVIDERS Conditions of...

  3. Agricultural pricing policy in Kenya : scope and impact

    NARCIS (Netherlands)

    Meilink, H.A.

    1985-01-01

    Reviews the findings of available studies and reports thought to be of relevance to policy makers. A discussion of the institutional framework, of criteria used in price-setting procedures, and of scope and objectives of the agricultural pricing policies is folowed by an examination of what these

  4. 32 CFR 155.2 - Applicability and scope.

    Science.gov (United States)

    2010-07-01

    ... National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY DEFENSE INDUSTRIAL PERSONNEL SECURITY CLEARANCE PROGRAM § 155.2 Applicability and scope. This part: (a) Applies to the Office.... (20) United States Trade Representative. (c) Applies to cases that the Defense Industrial Security...

  5. 28 CFR 1100.27 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... protections provided to victims and witnesses in federal victims' rights legislation as defined in this... Victims of Severe Forms of Trafficking in Persons § 1100.27 Purpose and scope. (a) Under section 107(c) of..., to the extent practicable, that victims of severe forms of trafficking in persons are housed in a...

  6. 44 CFR 352.20 - Purpose and scope.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Purpose and scope. 352.20 Section 352.20 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS COMMERCIAL NUCLEAR POWER PLANTS: EMERGENCY PREPAREDNESS PLANNING...

  7. 44 CFR 352.2 - Scope, purpose and applicability.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Scope, purpose and applicability. 352.2 Section 352.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS COMMERCIAL NUCLEAR POWER PLANTS: EMERGENCY PREPAREDNESS...

  8. 44 CFR 351.3 - Limitation of scope.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Limitation of scope. 351.3 Section 351.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS RADIOLOGICAL EMERGENCY PLANNING AND PREPAREDNESS General § 351.3...

  9. 41 CFR 60-50.1 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... 50-GUIDELINES ON DISCRIMINATION BECAUSE OF RELIGION OR NATIONAL ORIGIN § 60-50.1 Purpose and scope... performing under federally assisted construction contracts, without regard to religion or national origin. (b... religion and/or national origin. These guidelines are intended to remedy such unfair treatment. (c)...

  10. Industrial Cooperative Education Co-op: Scope and Sequence.

    Science.gov (United States)

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This guide, which was written as an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System, outlines the suggested scope and sequence of a 2-year cooperative program in industrial education. The guide consists of a course description;…

  11. 40 CFR 725.300 - Scope and purpose.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Scope and purpose. 725.300 Section 725.300 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Exemptions for Test Marketing § 725.300...

  12. 40 CFR 160.1 - Scope and applicability.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Scope and applicability. 160.1 Section 160.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS GOOD... for research or marketing permits for pesticide products regulated by the EPA. This part is...

  13. 10 CFR 455.72 - Scope of the grant.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Scope of the grant. 455.72 Section 455.72 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION GRANT PROGRAMS FOR SCHOOLS AND HOSPITALS AND BUILDINGS OWNED BY... installation of energy conservation measures to reduce energy consumption or measures to allow the use...

  14. 49 CFR 193.2001 - Scope of part.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY LIQUEFIED NATURAL GAS FACILITIES... LNG facilities used in the transportation of gas by pipeline that is subject to the pipeline safety... 49 Transportation 3 2010-10-01 2010-10-01 false Scope of part. 193.2001 Section 193.2001...

  15. 42 CFR 431.954 - Basis and scope.

    Science.gov (United States)

    2010-10-01

    ... Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... Improper Payments in Medicaid and CHIP § 431.954 Basis and scope. (a) Basis. The statutory bases for this... or child health assistance under CHIP; and State-specific sample sizes for application of the PERM...

  16. 12 CFR 308.500 - Basis, purpose, and scope.

    Science.gov (United States)

    2010-01-01

    ....500 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE RULES OF PRACTICE AND PROCEDURE Program Fraud Civil Remedies and Procedures § 308.500 Basis, purpose, and scope. (a) Basis. This subpart implements the Program Fraud Civil Remedies Act, Pub. L. 99-509, sections 6101-6104...

  17. 41 CFR 105-62.000 - Scope of part.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Scope of part. 105-62.000 Section 105-62.000 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services...

  18. Places for active outdoor recreation – a scoping review

    DEFF Research Database (Denmark)

    Andkjær, Søren; Arvidsen, Jan

    2015-01-01

    The focus of the paper is on places and facilities for physical activity in nature and reports on a scoping literature review. The study aims to bring together research from several research areas, and the perspective is both of conceptual and systematic character. The purpose is to provide an ov...

  19. 31 CFR 29.201 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Purpose and scope. 29.201 Section 29.201 Money and Finance: Treasury Office of the Secretary of the Treasury FEDERAL BENEFIT PAYMENTS UNDER CERTAIN DISTRICT OF COLUMBIA RETIREMENT PROGRAMS Coordination With the District Government §...

  20. 34 CFR 668.230 - Scope and purpose.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Scope and purpose. 668.230 Section 668.230 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION STUDENT ASSISTANCE GENERAL PROVISIONS Financial Assistance for Students...

  1. 16 CFR 260.2 - Scope of guides.

    Science.gov (United States)

    2010-01-01

    ... through any other means, including marketing through digital or electronic means, such as the Internet or... ENVIRONMENTAL MARKETING CLAIMS § 260.2 Scope of guides. (a) These guides apply to environmental claims included in labeling, advertising, promotional materials and all other forms of marketing, whether...

  2. 12 CFR 25.11 - Authority, purposes, and scope.

    Science.gov (United States)

    2010-01-01

    ... bank's record of helping to meet the credit needs of its entire community, including low- and moderate...), and banks that engage only in one or more of the following activities: providing cash management... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Authority, purposes, and scope. 25.11...

  3. De betekenis van marktstructuren voor de scope van de onderneming

    NARCIS (Netherlands)

    H.R. Commandeur (Harry)

    2003-01-01

    textabstractDifferent market structures and value systems give insight into the changing environment in which companies operate. In this inaugural address the central question is: What is the influence of market structures on the scope of the firm?The objective is to give meaningful contributions to

  4. 20 CFR 903.1 - Purpose and scope of regulations.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Purpose and scope of regulations. 903.1 Section 903.1 Employees' Benefits JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES ACCESS TO RECORDS Records... all records maintained by the Joint Board for the Enrollment of Actuaries (Joint Board) which...

  5. 42 CFR 403.500 - Basis, scope, and definition.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Basis, scope, and definition. 403.500 Section 403.500 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Beneficiary Counseling and Assistance Grants §...

  6. 10 CFR 490.200 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Purpose and scope. 490.200 Section 490.200 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet... duty motor vehicles acquired for State fleets be alternative fueled vehicles....

  7. 10 CFR 490.500 - Purpose and Scope.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Purpose and Scope. 490.500 Section 490.500 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle... 508 of the Act, which provides for the allocation of credits to fleets or covered persons who...

  8. 31 CFR 29.301 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... retirement benefits under the Police and Firefighters Plan or the Teachers Plan. (2) This subpart provides... problems. (b)(1) This subpart applies only to benefits under the Police and Firefighters Plan or the... determination and review of eligibility and payments, and financial management, are beyond the scope of...

  9. 48 CFR 3.700 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... source selection information in exchange for a thing of value or to give anyone a competitive advantage... BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Voiding and Rescinding Contracts 3.700 Scope of... information has been disclosed or received in exchange for a thing of value, or for the purpose of obtaining...

  10. 5 CFR 1201.72 - Explanation and scope of discovery.

    Science.gov (United States)

    2010-01-01

    ... location of persons with knowledge of relevant facts. Discovery requests that are directed to nonparties... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Explanation and scope of discovery. 1201... PROCEDURES PRACTICES AND PROCEDURES Procedures for Appellate Cases Discovery § 1201.72 Explanation and...

  11. 41 CFR 109-1.5300 - Scope of subpart.

    Science.gov (United States)

    2010-07-01

    ....53-Management of High Risk Personal Property § 109-1.5300 Scope of subpart. (a) This subpart provides identification, accounting, control, and disposal policy guidance for the following categories of high risk... categories of high risk personal property are controlled by other life cycle management programs...

  12. Understanding, scoping and defining user experience: A survey approach

    NARCIS (Netherlands)

    Law, E.L.C.; Roto, V.; Hassenzahl, M.; Vermeeren, A.P.O.S.; Kort, J.

    2009-01-01

    Despite the growing interest in user experience (UX), it has been hard to gain a common agreement on the nature and scope of UX. In this paper, we report a survey that gathered the views on UX of 275 researchers and practitioners from academia and industry. Most respondents agree that UX is dynamic,

  13. 42 CFR 402.1 - Basis and scope.

    Science.gov (United States)

    2010-10-01

    ... any outpatient therapy services or comprehensive outpatient rehabilitation services on other than an... 42 Public Health 2 2010-10-01 2010-10-01 false Basis and scope. 402.1 Section 402.1 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CIVIL...

  14. 42 CFR 411.20 - Basis and scope.

    Science.gov (United States)

    2010-10-01

    ... virtue of his or her current employment status or the current employment status of a family member. (2... 42 Public Health 2 2010-10-01 2010-10-01 false Basis and scope. 411.20 Section 411.20 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM...

  15. 42 CFR 411.100 - Basis and scope.

    Science.gov (United States)

    2010-10-01

    ... by virtue of the individual's or a family member's current employment status with an employer... 42 Public Health 2 2010-10-01 2010-10-01 false Basis and scope. 411.100 Section 411.100 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM...

  16. Understanding the Code: scope of the duty of confidentiality.

    Science.gov (United States)

    Griffith, Richard

    2015-06-01

    In a series explaining the law underpinning the Nursing and Midwifery Council's revised Code (2015), this month's article considers the scope of a district nurse's duty of confidence. The article explains how three areas of law are drawn together to provide maximum protection against inappropriate disclosure of sensitive health information.

  17. 28 CFR 524.70 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... TRANSFER CLASSIFICATION OF INMATES Central Inmate Monitoring (CIM) System § 524.70 Purpose and scope. The... monitoring (CIM) cases, require a higher level of review which may include Central Office and/or Regional... preclude a CIM case from such activities, when the inmate is otherwise eligible, but rather is to...

  18. 42 CFR 410.68 - Antigens: Scope and conditions.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Antigens: Scope and conditions. 410.68 Section 410.68 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Medical and Other Health Services §...

  19. 14 CFR 1207.201 - Scope of subpart.

    Science.gov (United States)

    2010-01-01

    ... who are subject to the restrictions of Title V of the Ethics of Government Act of 1978, as amended... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Scope of subpart. 1207.201 Section 1207.201 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION STANDARDS OF CONDUCT...

  20. 30 CFR 206.150 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... PRODUCT VALUATION Federal Gas § 206.150 Purpose and scope. (a) This subpart is applicable to all gas production from Federal oil and gas leases. The purpose of this subpart is to establish the value of production for royalty purposes consistent with the mineral leasing laws, other applicable laws and...