WorldWideScience

Sample records for 3d computational multiscale

  1. Fatigue of multiscale composites with secondary nanoplatelet reinforcement: 3D computational analysis

    DEFF Research Database (Denmark)

    Dai, Gaoming; Mishnaevsky, Leon, Jr.

    2014-01-01

    3D numerical simulations of fatigue damage of multiscale fiber reinforced polymer composites with secondary nanoclay reinforcement are carried out. Macro–micro FE models of the multiscale composites are generated automatically using Python based software. The effect of the nanoclay reinforcement...... (localized in the fiber/matrix interface (fiber sizing) and distributed throughout the matrix) on the crack path, damage mechanisms and fatigue behavior is investigated in numerical experiments. It was observed that the composites with secondary nanoreinforcement localized in the fiber sizing ensure higher...

  2. Quasi-3D Multi-scale Modeling Framework Development

    Science.gov (United States)

    Arakawa, A.; Jung, J.

    2008-12-01

    When models are truncated in or near an energetically active range of the spectrum, model physics must be changed as the resolution changes. The model physics of GCMs and that of CRMs are, however, quite different from each other and at present there is no unified formulation of model physics that automatically provides transition between these model physics. The Quasi-3D (Q3D) Multi-scale Modeling Framework (MMF) is an attempt to bridge this gap. Like the recently proposed Heterogeneous Multiscale Method (HMM) (E and Engquist 2003), MMF combines a macroscopic model, GCM, and a microscopic model, CRM. Unlike the traditional multiscale methods such as the multi-grid and adapted mesh refinement techniques, HMM and MMF are for solving multi-physics problems. They share the common objective "to design combined macroscopic-microscopic computational methods that are much more efficient than solving the full microscopic model and at the same time give the information we need" (E et al. 2008). The question is then how to meet this objective in practice, which can be highly problem dependent. In HHM, the efficiency is gained typically by localization of the microscale problem. Following the pioneering work by Grabowski and Smolarkiewicz (1999) and Grabowski (2001), MMF takes advantage of the fact that 2D CRMs are reasonably successful in simulating deep clouds. In this approach, the efficiency is gained by sacrificing the three-dimensionality of cloud-scale motion. It also "localizes" the algorithm through embedding a CRM in each GCM grid box using cyclic boundary condition. The Q3D MMF is an attempt to reduce the expense due to these constraints by partially including the cloud-scale 3D effects and extending the CRM beyond individual GCM grid boxes. As currently formulated, the Q3D MMF is a 4D estimation/prediction framework that combines a GCM with a 3D anelastic cloud-resolving vector vorticity equation model (VVM) applied to a network of horizontal grids. The network

  3. 3D surface reconstruction multi-scale hierarchical approaches

    CERN Document Server

    Bellocchio, Francesco; Ferrari, Stefano; Piuri, Vincenzo

    2012-01-01

    3D Surface Reconstruction: Multi-Scale Hierarchical Approaches presents methods to model 3D objects in an incremental way so as to capture more finer details at each step. The configuration of the model parameters, the rationale and solutions are described and discussed in detail so the reader has a strong understanding of the methodology. Modeling starts from data captured by 3D digitizers and makes the process even more clear and engaging. Innovative approaches, based on two popular machine learning paradigms, namely Radial Basis Functions and the Support Vector Machines, are also introduced

  4. A study of different approaches for multi-scale sensitivity analysis of the TALL-3D experiment using thermal-hydraulic computer codes

    International Nuclear Information System (INIS)

    In the context of the FP7 European THINS Project, complex thermal-hydraulic phenomena relevant for the Generation IV of nuclear reactors are investigated. KTH (Sweden) built the TALL-3D facility to investigate the transition from forced to natural circulation of the Lead-Bismuth Eutectic (LBE) in a pool connected to a 3-leg primary circuit with two heaters and a heat exchanger. The simulation of such 3D phenomena is a challenging task. GRS (Germany) developed the coupling between the Computational Fluid Dynamics (CFD) code ANSYS CFX and the System Analysis code ATHLET. Such coupled codes combine the advantages of CFD, which allow a fine resolution of 3D phenomena, and of System Analysis codes, which are fast running. TUM (Germany) is responsible for the Uncertainty and Sensitivity Analysis of the coupled ATHLET-CFX model in the THINS Project. The influence of modeling uncertainty on simulation results needs to be assessed to characterize and to improve the model and, eventually, to assess its performance against experimental data. TUM has developed a computational framework capable of propagating model input uncertainty through coupled codes. This framework can also be used to apply different approaches for the assessment of the influence of the uncertain input parameters on the model output (Sensitivity Analysis). The work reported in this paper focuses on three methods for the assessment of the sensitivity of the results to the modeling uncertainty. The first method (Morris) allows for the computation of the Elementary Effects resulting from the input parameters. This method is widely used to perform Screening Analysis. The second method (Spearman's rank correlation) relies on regression-based non-parametric measures. This method is suitable if the relation between the input and the output variables is at least monotonic, with the advantage of a low computational cost. The last method (Sobol') computes so-called total effect indices which account for

  5. 3D Multiscale Modelling of Angiogenesis and Vascular Tumour Growth

    KAUST Repository

    Perfahl, H.

    2012-11-01

    We present a three-dimensional, multiscale model of vascular tumour growth, which couples nutrient/growth factor transport, blood flow, angiogenesis, vascular remodelling, movement of and interactions between normal and tumour cells, and nutrient-dependent cell cycle dynamics within each cell. We present computational simulations which show how a vascular network may evolve and interact with tumour and healthy cells. We also demonstrate how our model may be combined with experimental data, to predict the spatio-temporal evolution of a vascular tumour.

  6. Parametrizable cameras for 3D computational steering

    NARCIS (Netherlands)

    Mulder, J.D.; Wijk, J.J. van

    1997-01-01

    We present a method for the definition of multiple views in 3D interfaces for computational steering. The method uses the concept of a point-based parametrizable camera object. This concept enables a user to create and configure multiple views on his custom 3D interface in an intuitive graphical man

  7. Multiscale 3-D shape representation and segmentation using spherical wavelets.

    Science.gov (United States)

    Nain, Delphine; Haker, Steven; Bobick, Aaron; Tannenbaum, Allen

    2007-04-01

    our multiscale prior and 2) a segmentation task. In the reconstruction task, our results show that for a given training set size, our algorithm significantly improves the approximation of shapes in a testing set over the Point Distribution Model, which tends to oversmooth data. In the segmentation task, our validation shows our algorithm is computationally efficient and outperforms the Active Shape Model algorithm, by capturing finer shape details. PMID:17427745

  8. Multiscale 3D bioimaging: from cell, tissue to whole organism

    Science.gov (United States)

    Lau, S. H.; Wang, Ge; Chandrasekeran, Margam; Fan, Victor; Nazrul, Mohd; Chang, Hauyee; Fong, Tiffany; Gelb, Jeff; Feser, Michael; Yun, Wenbing

    2009-05-01

    While electron microscopes and AFMs are capable of high resolution imaging to molecular levels, there is an ongoing problem in integrating these results into the larger scale structure and functions of tissue and organs within a complex organism. Imaging biological samples with optical microscopy is predominantly done with histology and immunohistochemistry, which can take up to a several weeks to prepare, are artifact prone and only available as individual 2D images. At the nano resolution scale, the higher resolution electron microscopy and AFM are used, but again these require destructive sample preparation and data are in 2D. To bridge this gap, we describe a rapid non invasive hierarchical bioimaging technique using a novel lab based x-ray computed tomography to characterize complex biological organism in multiscale- from whole organ (mesoscale) to calcified and soft tissue (microscale), to subcellular structures, nanomaterials and cellular-scaffold interaction (nanoscale). While MicroCT (micro x-ray computed tomography) is gaining in popularity for non invasive bones and tissue imaging, contrast and resolution are still vastly inadequate compared to histology. In this study we will present multiscale results from a novel microCT and nanoCT (nano x-ray tomography system). The novel MicroCT can image large specimen and tissue sample at histology resolution of submicron voxel resolution, often without contrast agents, while the nanoCT using x-ray optics similar to those used in synchrotron radiation facilities, has 20nm voxel resolution, suitable for studying cellular, subcellular morphology and nanomaterials. Multiscale examples involving both calcified and soft tissue will be illustrated, which include imaging a rat tibia to the individual channels of osteocyte canaliculli and lacunae and an unstained whole murine lung to its alveoli. The role of the novel CT will also be discussed as a possible means for rapid virtual histology using a biopsy of a human

  9. Computer Modelling of 3D Geological Surface

    CERN Document Server

    Kodge, B G

    2011-01-01

    The geological surveying presently uses methods and tools for the computer modeling of 3D-structures of the geographical subsurface and geotechnical characterization as well as the application of geoinformation systems for management and analysis of spatial data, and their cartographic presentation. The objectives of this paper are to present a 3D geological surface model of Latur district in Maharashtra state of India. This study is undertaken through the several processes which are discussed in this paper to generate and visualize the automated 3D geological surface model of a projected area.

  10. Towards distributed multiscale computing for the VPH

    NARCIS (Netherlands)

    A.G. Hoekstra; P. Coveney

    2010-01-01

    Multiscale modeling is fundamental to the Virtual Physiological Human (VPH) initiative. Most detailed three-dimensional multiscale models lead to prohibitive computational demands. As a possible solution we present MAPPER, a computational science infrastructure for Distributed Multiscale Computing o

  11. Infra Red 3D Computer Mouse

    DEFF Research Database (Denmark)

    Harbo, Anders La-Cour; Stoustrup, Jakob

    2000-01-01

    The infra red 3D mouse is a three dimensional input device to a computer. It works by determining the position of an arbitrary object (like a hand) by emitting infra red signals from a number of locations and measuring the reflected intensities. To maximize stability, robustness, and use...

  12. 3D Cameras: 3D Computer Vision of Wide Scope

    OpenAIRE

    May, Stefan; Pervoelz, Kai; Surmann, Hartmut

    2007-01-01

    First of all, a short comparison of range sensors and their underlying principles was given. The chapter further focused on 3D cameras. The latest innovations have given a significant improvement for the measurement accuracy, wherefore this technology has attracted attention in the robotics community. This was also the motivation for the examination in this chapter. On this account, several applications were presented, which represents common problems in the domain of autonomous robotics. For...

  13. Multiscale Computing with the Multiscale Modeling Library and Runtime Environment

    OpenAIRE

    Borgdorff J.; Mamonski M.; Bosak B.; Groen D.; Ben Belgacem M.; Kurowski K.; Hoekstra A.G.

    2013-01-01

    We introduce a software tool to simulate multiscale models: The Multiscale Coupling Library and Environment 2 (MUSCLE 2). MUSCLE 2 is a component-based modeling tool inspired by the multiscale modeling and simulation framework, with an easy-to-use API which supports Java, C++, C, and Fortran. We present MUSCLE 2's runtime features, such as its distributed computing capabilities, and its benefits to multiscale modelers. We also describe two multiscale models that use MUSCLE 2 to do distributed...

  14. [Computer-assisted 3D phonetography].

    Science.gov (United States)

    Neuschaefer-Rube, C; Klajman, S

    1996-10-01

    Profiles of fundamental frequency sound pressure levels and voice duration are measured separately in clinical practice. It was the aim of the present study to combine the two examinations, in order to estimate the relationship between pitch, sound pressure level and voice duration and to develop a new computer-assisted graph. A three-dimensional (3D) wireframe phonogram was constructed based on SPL profiles to obtain a general view of the parameters recorded. We have termed this "phonetography". Variable further projections were selected for the analysis of different aspects of parametric relationships. The results in 21 healthy volunteers and 4 patients with hyperfunctional dysphonias demonstrated that there were three typical figures of the 3D phonograms produced, depending on the relationship between voice duration when soft ("piano") compared to loud ("forte"). In one-third of the healthy volunteers, the values of the piano voice duration were greater than those of forte for almost all pitches examined. In two-thirds of the healthy subjects the values of forte voice duration were partly greater, as were those of piano voice duration. All of the patients showed voice duration values greater for forte than for piano. The results of the study demonstrate that the 3D phonogram is a useful tool for obtaining new insights into various relationships of voice parameters.

  15. Practical algorithms for 3D computer graphics

    CERN Document Server

    Ferguson, R Stuart

    2013-01-01

    ""A valuable book to accompany any course that mixes the theory and practice of 3D graphics. The book's web site has many useful programs and code samples.""-Karen Rafferty, Queen's University, Belfast""The topics covered by this book are backed by the OpenFX modeling and animation software. This is a big plus in that it provides a practical perspective and encourages experimentation. … [This] will offer students a more interesting and hands-on learning experience, especially for those wishing to pursue a career in computer game development.""-Naganand Madhavapeddy, GameDeveloper>

  16. Meanie3D - a mean-shift based, multivariate, multi-scale clustering and tracking algorithm

    Science.gov (United States)

    Simon, Jürgen-Lorenz; Malte, Diederich; Silke, Troemel

    2014-05-01

    Project OASE is the one of 5 work groups at the HErZ (Hans Ertel Centre for Weather Research), an ongoing effort by the German weather service (DWD) to further research at Universities concerning weather prediction. The goal of project OASE is to gain an object-based perspective on convective events by identifying them early in the onset of convective initiation and follow then through the entire lifecycle. The ability to follow objects in this fashion requires new ways of object definition and tracking, which incorporate all the available data sets of interest, such as Satellite imagery, weather Radar or lightning counts. The Meanie3D algorithm provides the necessary tool for this purpose. Core features of this new approach to clustering (object identification) and tracking are the ability to identify objects using the mean-shift algorithm applied to a multitude of variables (multivariate), as well as the ability to detect objects on various scales (multi-scale) using elements of Scale-Space theory. The algorithm works in 2D as well as 3D without modifications. It is an extension of a method well known from the field of computer vision and image processing, which has been tailored to serve the needs of the meteorological community. In spite of the special application to be demonstrated here (like convective initiation), the algorithm is easily tailored to provide clustering and tracking for a wide class of data sets and problems. In this talk, the demonstration is carried out on two of the OASE group's own composite sets. One is a 2D nationwide composite of Germany including C-Band Radar (2D) and Satellite information, the other a 3D local composite of the Bonn/Jülich area containing a high-resolution 3D X-Band Radar composite.

  17. Numerical Analysis of Multiscale Computations

    CERN Document Server

    Engquist, Björn; Tsai, Yen-Hsi R

    2012-01-01

    This book is a snapshot of current research in multiscale modeling, computations and applications. It covers fundamental mathematical theory, numerical algorithms as well as practical computational advice for analysing single and multiphysics models containing a variety of scales in time and space. Complex fluids, porous media flow and oscillatory dynamical systems are treated in some extra depth, as well as tools like analytical and numerical homogenization, and fast multipole method.

  18. 3D Vectorial Time Domain Computational Integrated Photonics

    Energy Technology Data Exchange (ETDEWEB)

    Kallman, J S; Bond, T C; Koning, J M; Stowell, M L

    2007-02-16

    The design of integrated photonic structures poses considerable challenges. 3D-Time-Domain design tools are fundamental in enabling technologies such as all-optical logic, photonic bandgap sensors, THz imaging, and fast radiation diagnostics. Such technologies are essential to LLNL and WFO sponsors for a broad range of applications: encryption for communications and surveillance sensors (NSA, NAI and IDIV/PAT); high density optical interconnects for high-performance computing (ASCI); high-bandwidth instrumentation for NIF diagnostics; micro-sensor development for weapon miniaturization within the Stockpile Stewardship and DNT programs; and applications within HSO for CBNP detection devices. While there exist a number of photonics simulation tools on the market, they primarily model devices of interest to the communications industry. We saw the need to extend our previous software to match the Laboratory's unique emerging needs. These include modeling novel material effects (such as those of radiation induced carrier concentrations on refractive index) and device configurations (RadTracker bulk optics with radiation induced details, Optical Logic edge emitting lasers with lateral optical inputs). In addition we foresaw significant advantages to expanding our own internal simulation codes: parallel supercomputing could be incorporated from the start, and the simulation source code would be accessible for modification and extension. This work addressed Engineering's Simulation Technology Focus Area, specifically photonics. Problems addressed from the Engineering roadmap of the time included modeling the Auston switch (an important THz source/receiver), modeling Vertical Cavity Surface Emitting Lasers (VCSELs, which had been envisioned as part of fast radiation sensors), and multi-scale modeling of optical systems (for a variety of applications). We proposed to develop novel techniques to numerically solve the 3D multi-scale propagation problem for both the

  19. Fusing Multiscale Charts into 3D ENC Systems Based on Underwater Topography and Remote Sensing Image

    Directory of Open Access Journals (Sweden)

    Tao Liu

    2015-01-01

    Full Text Available The purpose of this study is to propose an approach to fuse multiscale charts into three-dimensional (3D electronic navigational chart (ENC systems based on underwater topography and remote sensing image. This is the first time that the fusion of multiscale standard ENCs in the 3D ENC system has been studied. First, a view-dependent visualization technology is presented for the determination of the display condition of a chart. Second, a map sheet processing method is described for dealing with the map sheet splice problem. A process order called “3D order” is designed to adapt to the characteristics of the chart. A map sheet clipping process is described to deal with the overlap between the adjacent map sheets. And our strategy for map sheet splice is proposed. Third, the rendering method for ENC objects in the 3D ENC system is introduced. Fourth, our picking-up method for ENC objects is proposed. Finally, we implement the above methods in our system: automotive intelligent chart (AIC 3D electronic chart display and information systems (ECDIS. And our method can handle the fusion problem well.

  20. Percolation properties of 3-D multiscale pore networks: how connectivity controls soil filtration processes

    Directory of Open Access Journals (Sweden)

    E. M. A. Perrier

    2010-04-01

    Full Text Available Quantifying the connectivity of pore networks is a key issue not only for modelling fluid flow and solute transport in porous media but also for assessing the ability of soil ecosystems to filter bacteria, viruses and any type of living microorganisms as well inert particles which pose a contamination risk. Straining is the main mechanical component of filtration processes: it is due to size effects, when a given soil retains a conveyed entity larger than the pores through which it is attempting to pass. We postulate that the range of sizes of entities which can be trapped inside soils has to be associated with the large range of scales involved in natural soil structures and that information on the pore size distribution has to be complemented by information on a Critical Filtration Size (CFS delimiting the transition between percolating and non percolating regimes in multiscale pore networks. We show that the mass fractal dimensions which are classically used in soil science to quantify scaling laws in observed pore size distributions can also be used to build 3-D multiscale models of pore networks exhibiting such a critical transition. We extend to the 3-D case a new theoretical approach recently developed to address the connectivity of 2-D fractal networks (Bird and Perrier, 2009. Theoretical arguments based on renormalisation functions provide insight into multi-scale connectivity and a first estimation of CFS. Numerical experiments on 3-D prefractal media confirm the qualitative theory. These results open the way towards a new methodology to estimate soil filtration efficiency from the construction of soil structural models to be calibrated on available multiscale data.

  1. Percolation properties of 3-D multiscale pore networks: how connectivity controls soil filtration processes

    Directory of Open Access Journals (Sweden)

    E. M. A. Perrier

    2010-10-01

    Full Text Available Quantifying the connectivity of pore networks is a key issue not only for modelling fluid flow and solute transport in porous media but also for assessing the ability of soil ecosystems to filter bacteria, viruses and any type of living microorganisms as well inert particles which pose a contamination risk. Straining is the main mechanical component of filtration processes: it is due to size effects, when a given soil retains a conveyed entity larger than the pores through which it is attempting to pass. We postulate that the range of sizes of entities which can be trapped inside soils has to be associated with the large range of scales involved in natural soil structures and that information on the pore size distribution has to be complemented by information on a critical filtration size (CFS delimiting the transition between percolating and non percolating regimes in multiscale pore networks. We show that the mass fractal dimensions which are classically used in soil science to quantify scaling laws in observed pore size distributions can also be used to build 3-D multiscale models of pore networks exhibiting such a critical transition. We extend to the 3-D case a new theoretical approach recently developed to address the connectivity of 2-D fractal networks (Bird and Perrier, 2009. Theoretical arguments based on renormalisation functions provide insight into multi-scale connectivity and a first estimation of CFS. Numerical experiments on 3-D prefractal media confirm the qualitative theory. These results open the way towards a new methodology to estimate soil filtration efficiency from the construction of soil structural models to be calibrated on available multiscale data.

  2. CASTLE3D - A Computer Aided System for Labelling Archaeological Excavations in 3D

    Science.gov (United States)

    Houshiar, H.; Borrmann, D.; Elseberg, J.; Nüchter, A.; Näth, F.; Winkler, S.

    2015-08-01

    Documentation of archaeological excavation sites with conventional methods and tools such as hand drawings, measuring tape and archaeological notes is time consuming. This process is prone to human errors and the quality of the documentation depends on the qualification of the archaeologist on site. Use of modern technology and methods in 3D surveying and 3D robotics facilitate and improve this process. Computer-aided systems and databases improve the documentation quality and increase the speed of data acquisition. 3D laser scanning is the state of the art in modelling archaeological excavation sites, historical sites and even entire cities or landscapes. Modern laser scanners are capable of data acquisition of up to 1 million points per second. This provides a very detailed 3D point cloud of the environment. 3D point clouds and 3D models of an excavation site provide a better representation of the environment for the archaeologist and for documentation. The point cloud can be used both for further studies on the excavation and for the presentation of results. This paper introduces a Computer aided system for labelling archaeological excavations in 3D (CASTLE3D). Consisting of a set of tools for recording and georeferencing the 3D data from an excavation site, CASTLE3D is a novel documentation approach in industrial archaeology. It provides a 2D and 3D visualisation of the data and an easy-to-use interface that enables the archaeologist to select regions of interest and to interact with the data in both representations. The 2D visualisation and a 3D orthogonal view of the data provide cuts of the environment that resemble the traditional hand drawings. The 3D perspective view gives a realistic view of the environment. CASTLE3D is designed as an easy-to-use on-site semantic mapping tool for archaeologists. Each project contains a predefined set of semantic information that can be used to label findings in the data. Multiple regions of interest can be joined under

  3. Computer animation for articulated 3D characters

    NARCIS (Netherlands)

    Kiss, S.

    2002-01-01

    We present a review of the computer animation literature, mainly concentrating on articulated characters and at least some degree of interactivity or real time simulation. Advances in dierent techniques such as key-frame, motion capture (also known as mocap), dynamics, inverse kinematics (IK), contr

  4. Distributed infrastructure for multiscale computing

    NARCIS (Netherlands)

    S.J. Zasada; M. Mamonski; D. Groen; J. Borgdorff; I. Saverchenko; T. Piontek; K. Kurowski; P.V. Coveney

    2012-01-01

    Today scientists and engineers are commonly faced with the challenge of modelling, predicting and controlling multiscale systems which cross scientific disciplines and where several processes acting at different scales coexist and interact. Such multidisciplinary multiscale models, when simulated in

  5. Multi-scale modelling of strongly heterogeneous 3D composite structures using spatial Voronoi tessellation

    Science.gov (United States)

    El Said, Bassam; Ivanov, Dmitry; Long, Andrew C.; Hallett, Stephen R.

    2016-03-01

    3D composite materials are characterized by complex internal yarn architectures, leading to complex deformation and failure development mechanisms. Net-shaped preforms, which are originally periodic in nature, lose their periodicity when the fabric is draped, deformed on a tool, and consolidated to create geometrically complex composite components. As a result, the internal yarn architecture, which dominates the mechanical behaviour, becomes dependent on the structural geometry. Hence, predicting the mechanical behaviour of 3D composites requires an accurate representation of the yarn architecture within structural scale models. When applied to 3D composites, conventional finite element modelling techniques are limited to either homogenised properties at the structural scale, or the unit cell scale for a more detailed material property definition. Consequently, these models fail to capture the complex phenomena occurring across multiple length scales and their effects on a 3D composite's mechanical response. Here a multi-scale modelling approach based on a 3D spatial Voronoi tessellation is proposed. The model creates an intermediate length scale suitable for homogenisation to deal with the non-periodic nature of the final material. Information is passed between the different length scales to allow for the effect of the structural geometry to be taken into account on the smaller scales. The stiffness and surface strain predictions from the proposed model have been found to be in good agreement with experimental results. The proposed modelling framework has been used to gain important insight into the behaviour of this category of materials. It has been observed that the strain and stress distributions are strongly dependent on the internal yarn architecture and consequently on the final component geometry. Even for simple coupon tests, the internal architecture and geometric effects dominate the mechanical response. Consequently, the behaviour of 3D woven

  6. Design for scalability in 3D computer graphics architectures

    DEFF Research Database (Denmark)

    Holten-Lund, Hans Erik

    2002-01-01

    This thesis describes useful methods and techniques for designing scalable hybrid parallel rendering architectures for 3D computer graphics. Various techniques for utilizing parallelism in a pipelines system are analyzed. During the Ph.D study a prototype 3D graphics architecture named Hybris has...... been developed. Hybris is a prototype rendering architeture which can be tailored to many specific 3D graphics applications and implemented in various ways. Parallel software implementations for both single and multi-processor Windows 2000 system have been demonstrated. Working hardware...

  7. A multi-scale controlled tissue engineering scaffold prepared by 3D printing and NFES technology

    Science.gov (United States)

    Yan, Feifei; Liu, Yuanyuan; Chen, Haiping; Zhang, Fuhua; Zheng, Lulu; Hu, Qingxi

    2014-03-01

    The current focus in the field of life science is the use of tissue engineering scaffolds to repair human organs, which has shown great potential in clinical applications. Extracellular matrix morphology and the performance and internal structure of natural organs are required to meet certain requirements. Therefore, integrating multiple processes can effectively overcome the limitations of the individual processes and can take into account the needs of scaffolds for the material, structure, mechanical properties and many other aspects. This study combined the biological 3D printing technology and the near-field electro-spinning (NFES) process to prepare a multi-scale controlled tissue engineering scaffold. While using 3D printing technology to directly prepare the macro-scaffold, the compositing NFES process to build tissue micro-morphology ultimately formed a tissue engineering scaffold which has the specific extracellular matrix structure. This scaffold not only takes into account the material, structure, performance and many other requirements, but also focuses on resolving the controllability problems in macro- and micro-forming which further aim to induce cell directed differentiation, reproduction and, ultimately, the formation of target tissue organs. It has in-depth immeasurable significance to build ideal scaffolds and further promote the application of tissue engineering.

  8. A multi-scale controlled tissue engineering scaffold prepared by 3D printing and NFES technology

    Directory of Open Access Journals (Sweden)

    Feifei Yan

    2014-03-01

    Full Text Available The current focus in the field of life science is the use of tissue engineering scaffolds to repair human organs, which has shown great potential in clinical applications. Extracellular matrix morphology and the performance and internal structure of natural organs are required to meet certain requirements. Therefore, integrating multiple processes can effectively overcome the limitations of the individual processes and can take into account the needs of scaffolds for the material, structure, mechanical properties and many other aspects. This study combined the biological 3D printing technology and the near-field electro-spinning (NFES process to prepare a multi-scale controlled tissue engineering scaffold. While using 3D printing technology to directly prepare the macro-scaffold, the compositing NFES process to build tissue micro-morphology ultimately formed a tissue engineering scaffold which has the specific extracellular matrix structure. This scaffold not only takes into account the material, structure, performance and many other requirements, but also focuses on resolving the controllability problems in macro- and micro-forming which further aim to induce cell directed differentiation, reproduction and, ultimately, the formation of target tissue organs. It has in-depth immeasurable significance to build ideal scaffolds and further promote the application of tissue engineering.

  9. A MULTISCALE APPROACH TO THE REPRESENTATION OF 3D IMAGES, WITH APPLICATION TO POLYMER SOLAR CELLS

    Directory of Open Access Journals (Sweden)

    Ralf Thiedmann

    2011-03-01

    Full Text Available A multiscale approach to the description of geometrically complex 3D image data is proposed which distinguishes between morphological features on a ‘macro-scale’ and a ‘micro-scale’. Since our method is mainly tailored to nanostructures observed in composite materials consisting of two different phases, an appropriate binarization of grayscale images is required first. Then, a morphological smoothing is applied to extract the structural information from binarized image data on the ‘macro-scale’. A stochastic algorithm is developed for the morphologically smoothed images whose goal is to find a suitable representation of the macro-scale structure by unions of overlapping spheres. Such representations can be interpreted as marked point patterns. They lead to an enormous reduction of data and allow the application of well-known tools from point-process theory for their analysis and structural modeling. All those voxels which have been ‘misspecified’ by the morphological smoothing and subsequent representation by unions of overlapping spheres are interpreted as ‘micro-scale’ structure. The exemplary data sets considered in this paper are 3D grayscale images of photoactive layers in hybrid solar cells gained by electron tomography. These composite materials consist of two phases: a polymer phase and a zinc oxide phase. The macro-scale structure of the latter is represented by unions of overlapping spheres.

  10. Multi-Scale Characterization of the PEPCK-Cmus Mouse through 3D Cryo-Imaging

    Directory of Open Access Journals (Sweden)

    Debashish Roy

    2010-01-01

    Full Text Available We have developed, for the Case 3D Cryo-imaging system, a specialized, multiscale visualization scheme which provides color-rich volume rendering and multiplanar reformatting enabling one to visualize an entire mouse and zoom in to organ, tissue, and microscopic scales. With this system, we have anatomically characterized, in 3D, from whole animal to tissue level, a transgenic mouse and compared it with its control. The transgenic mouse overexpresses the cytosolic form of phosphoenolpyruvate carboxykinase (PEPCK-C in its skeletal muscle and is capable of greatly enhanced physical endurance and has a longer life-span and reproductive life as compared to control animals. We semiautomatically analyzed selected organs such as kidney, heart, adrenal gland, spleen, and ovaries and found comparatively enlarged heart, much less visceral, subcutaneous, and pericardial adipose tissue, and higher tibia-to-femur ratio in the transgenic animal. Microscopically, individual skeletal muscle fibers, fine mesenteric blood vessels, and intestinal villi, among others, were clearly seen.

  11. Practical rendering and computation with Direct3D 11

    CERN Document Server

    Zink, Jason; Hoxley, Jack

    2011-01-01

    Practical Rendering and Computation with Direct3D 11 packs in documentation and in-depth coverage of basic and high-level concepts related to using Direct 3D 11 and is a top pick for any serious programming collection. … perfect for a wide range of users. Any interested in computation and multicore models will find this packed with examples and technical applications.-Midwest Book Review, October 2011The authors have generously provided us with an optimal blend of concepts and philosophy, illustrative figures to clarify the more difficult points, and source code fragments to make the ideas con

  12. Education System Using Interactive 3D Computer Graphics (3D-CG) Animation and Scenario Language for Teaching Materials

    Science.gov (United States)

    Matsuda, Hiroshi; Shindo, Yoshiaki

    2006-01-01

    The 3D computer graphics (3D-CG) animation using a virtual actor's speaking is very effective as an educational medium. But it takes a long time to produce a 3D-CG animation. To reduce the cost of producing 3D-CG educational contents and improve the capability of the education system, we have developed a new education system using Virtual Actor.…

  13. Advanced computational tools for 3-D seismic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Barhen, J.; Glover, C.W.; Protopopescu, V.A. [Oak Ridge National Lab., TN (United States)] [and others

    1996-06-01

    The global objective of this effort is to develop advanced computational tools for 3-D seismic analysis, and test the products using a model dataset developed under the joint aegis of the United States` Society of Exploration Geophysicists (SEG) and the European Association of Exploration Geophysicists (EAEG). The goal is to enhance the value to the oil industry of the SEG/EAEG modeling project, carried out with US Department of Energy (DOE) funding in FY` 93-95. The primary objective of the ORNL Center for Engineering Systems Advanced Research (CESAR) is to spearhead the computational innovations techniques that would enable a revolutionary advance in 3-D seismic analysis. The CESAR effort is carried out in collaboration with world-class domain experts from leading universities, and in close coordination with other national laboratories and oil industry partners.

  14. 3D multiscale micromechanical model of wood: From annual rings to microfibrils

    DEFF Research Database (Denmark)

    Qing, Hai; Mishnaevsky, Leon

    2010-01-01

    A 3D micromechanical analytical-computational model of softwood, which takes into account the wood microstructures at four scale levels, from microfibrils to annual rings, is developed. For the analysis of the effect of the annual rings structure on the properties of softwood, an improved rule......-of-mixture model, based on 3D orthotropic stress–strain relations and taking into account the compatibility of deformations at the interface of two phases and equilibrium of tractions at phase boundaries, is proposed. The improved rule of mixture model (IRoM) was compared with the classical rule-of-mixture (Ro......, 2009a) and (Qing and Mishnaevsky, 2009b). Using the combined four-level model, the effect of wood density, microfibril angle (MFA) and cell shape angle (CSA) on the Young’s moduli, Poisson’s ratios and shrinkage properties of softwood has been investigated in numerical experiments. The simulations were...

  15. Cardiac Multi-detector CT Segmentation Based on Multiscale Directional Edge Detector and 3D Level Set.

    Science.gov (United States)

    Antunes, Sofia; Esposito, Antonio; Palmisano, Anna; Colantoni, Caterina; Cerutti, Sergio; Rizzo, Giovanna

    2016-05-01

    Extraction of the cardiac surfaces of interest from multi-detector computed tomographic (MDCT) data is a pre-requisite step for cardiac analysis, as well as for image guidance procedures. Most of the existing methods need manual corrections, which is time-consuming. We present a fully automatic segmentation technique for the extraction of the right ventricle, left ventricular endocardium and epicardium from MDCT images. The method consists in a 3D level set surface evolution approach coupled to a new stopping function based on a multiscale directional second derivative Gaussian filter, which is able to stop propagation precisely on the real boundary of the structures of interest. We validated the segmentation method on 18 MDCT volumes from healthy and pathologic subjects using manual segmentation performed by a team of expert radiologists as gold standard. Segmentation errors were assessed for each structure resulting in a surface-to-surface mean error below 0.5 mm and a percentage of surface distance with errors less than 1 mm above 80%. Moreover, in comparison to other segmentation approaches, already proposed in previous work, our method presented an improved accuracy (with surface distance errors less than 1 mm increased of 8-20% for all structures). The obtained results suggest that our approach is accurate and effective for the segmentation of ventricular cavities and myocardium from MDCT images. PMID:26319010

  16. Dynamic 3D computed tomography scanner for vascular imaging

    Science.gov (United States)

    Lee, Mark K.; Holdsworth, David W.; Fenster, Aaron

    2000-04-01

    A 3D dynamic computed-tomography (CT) scanner was developed for imaging objects undergoing periodic motion. The scanner system has high spatial and sufficient temporal resolution to produce quantitative tomographic/volume images of objects such as excised arterial samples perfused under physiological pressure conditions and enables the measurements of the local dynamic elastic modulus (Edyn) of the arteries in the axial and longitudinal directions. The system was comprised of a high resolution modified x-ray image intensifier (XRII) based computed tomographic system and a computer-controlled cardiac flow simulator. A standard NTSC CCD camera with a macro lens was coupled to the electro-optically zoomed XRII to acquire dynamic volumetric images. Through prospective cardiac gating and computer synchronized control, a time-resolved sequence of 20 mm thick high resolution volume images of porcine aortic specimens during one simulated cardiac cycle were obtained. Performance evaluation of the scanners illustrated that tomographic images can be obtained with resolution as high as 3.2 mm-1 with only a 9% decrease in the resolution for objects moving at velocities of 1 cm/s in 2D mode and static spatial resolution of 3.55 mm-1 with only a 14% decrease in the resolution in 3D mode for objects moving at a velocity of 10 cm/s. Application of the system for imaging of intact excised arterial specimens under simulated physiological flow/pressure conditions enabled measurements of the Edyn of the arteries with a precision of +/- kPa for the 3D scanner. Evaluation of the Edyn in the axial and longitudinal direction produced values of 428 +/- 35 kPa and 728 +/- 71 kPa, demonstrating the isotropic and homogeneous viscoelastic nature of the vascular specimens. These values obtained from the Dynamic CT systems were not statistically different (p less than 0.05) from the values obtained by standard uniaxial tensile testing and volumetric measurements.

  17. Multiscale computation from a chemical engineering perspective

    Institute of Scientific and Technical Information of China (English)

    Li Jinghai

    2014-01-01

    This-paper-mainly-discusses-the-multiscale-computation-from-a-chemical-engineering-perspective.-From-the-application-designer’s-perspective,we-propose-a-new-approach-to-investigate-and-develop-both-flexi-ble-and-efficient-computer-architectures.-Based-on-the-requirements-of-applications-within-one-category,we-first-induce-and-extract-some-inherent-computing-patterns-or-core-computing-kernels-from-the-applications.-Some-computing-models-and-innovative-computing-architectures-will-then-be-developed-for-these-patterns-or-kernels,as-well-as-the-software-mapping-techniques.-Finally-those-applications-which-can-share-and-utilize-those-computing-patterns-or-kernels-can-be-executed-very-efficiently-on-those-novel-computing-architectures.-We-think-that-the-proposed-approach-may-not-be-achievable-within-the-existing-technology.-However,we-believe-that-it-will-be-available-in-the-near-future.-Hence,we-will-describe-this-approach-from-the-following-four-as-pects:multiscale-environment-in-the-world,-mesoscale-as-a-key-scale,-energy-minimization-multiscale-(EMMS)paradigm-and-our-perspective.

  18. Computing Radiative Transfer in a 3D Medium

    Science.gov (United States)

    Von Allmen, Paul; Lee, Seungwon

    2012-01-01

    A package of software computes the time-dependent propagation of a narrow laser beam in an arbitrary three- dimensional (3D) medium with absorption and scattering, using the transient-discrete-ordinates method and a direct integration method. Unlike prior software that utilizes a Monte Carlo method, this software enables simulation at very small signal-to-noise ratios. The ability to simulate propagation of a narrow laser beam in a 3D medium is an improvement over other discrete-ordinate software. Unlike other direct-integration software, this software is not limited to simulation of propagation of thermal radiation with broad angular spread in three dimensions or of a laser pulse with narrow angular spread in two dimensions. Uses for this software include (1) computing scattering of a pulsed laser beam on a material having given elastic scattering and absorption profiles, and (2) evaluating concepts for laser-based instruments for sensing oceanic turbulence and related measurements of oceanic mixed-layer depths. With suitable augmentation, this software could be used to compute radiative transfer in ultrasound imaging in biological tissues, radiative transfer in the upper Earth crust for oil exploration, and propagation of laser pulses in telecommunication applications.

  19. 3D artefact for concurrent scale calibration in Computed Tomography

    DEFF Research Database (Denmark)

    Stolfi, Alessandro; De Chiffre, Leonardo

    2016-01-01

    A novel artefact for calibration of the scale in 3D X-ray Computed Tomography (CT) is presented. The artefact comprises a carbon fibre tubular structure on which a number of reference ruby spheres are glued. The artefact is positioned and scanned together with the workpiece inside the CT scanner...... providing a reference system for measurement. The artefact allows a considerable reduction of time by compressing the full process of calibration, scanning, measurement, and re-calibration, into a single process. The method allows a considerable reduction of the amount of data generated from CT scanning...

  20. Multiscale Computing with the Multiscale Modeling Library and Runtime Environment

    NARCIS (Netherlands)

    J. Borgdorff; M. Mamonski; B. Bosak; D. Groen; M. Ben Belgacem; K. Kurowski; A.G. Hoekstra

    2013-01-01

    We introduce a software tool to simulate multiscale models: the Multiscale Coupling Library and Environment 2 (MUSCLE 2). MUSCLE 2 is a component-based modeling tool inspired by the multiscale modeling and simulation framework, with an easy-to-use API which supports Java, C++, C, and Fortran. We pre

  1. 3D ultrasound computer tomography: update from a clinical study

    Science.gov (United States)

    Hopp, T.; Zapf, M.; Kretzek, E.; Henrich, J.; Tukalo, A.; Gemmeke, H.; Kaiser, C.; Knaudt, J.; Ruiter, N. V.

    2016-04-01

    Ultrasound Computer Tomography (USCT) is a promising new imaging method for breast cancer diagnosis. We developed a 3D USCT system and tested it in a pilot study with encouraging results: 3D USCT was able to depict two carcinomas, which were present in contrast enhanced MRI volumes serving as ground truth. To overcome severe differences in the breast shape, an image registration was applied. We analyzed the correlation between average sound speed in the breast and the breast density estimated from segmented MRIs and found a positive correlation with R=0.70. Based on the results of the pilot study we now carry out a successive clinical study with 200 patients. For this we integrated our reconstruction methods and image post-processing into a comprehensive workflow. It includes a dedicated DICOM viewer for interactive assessment of fused USCT images. A new preview mode now allows intuitive and faster patient positioning. We updated the USCT system to decrease the data acquisition time by approximately factor two and to increase the penetration depth of the breast into the USCT aperture by 1 cm. Furthermore the compute-intensive reflectivity reconstruction was considerably accelerated, now allowing a sub-millimeter volume reconstruction in approximately 16 minutes. The updates made it possible to successfully image first patients in our ongoing clinical study.

  2. Computation of 3D form factors in complex environments

    International Nuclear Information System (INIS)

    The calculation of radiant interchange among opaque surfaces in a complex environment poses the general problem of determining the visible and hidden parts of the environment. In many thermal engineering applications, surfaces are separated by radiatively non-participating media and may be idealized as diffuse emitters and reflectors. Consenquently the net radiant energy fluxes are intimately related to purely geometrical quantities called form factors, that take into account hidden parts: the problem is reduced to the form factor evaluation. This paper presents the method developed for the computation of 3D form factors in the finite-element module of the system TRIO, which is a general computer code for thermal and fluid flow analysis. The method is derived from an algorithm devised for synthetic image generation. A comparison is performed with the standard contour integration method also implemented and suited to convex geometries. Several illustrative examples of finite-element thermal calculations in radiating enclosures are given

  3. Computational Modelling of Piston Ring Dynamics in 3D

    Directory of Open Access Journals (Sweden)

    Dlugoš Jozef

    2014-12-01

    Full Text Available Advanced computational models of a piston assembly based on the level of virtual prototypes require a detailed description of piston ring behaviour. Considering these requirements, the piston rings operate in regimes that cannot, in general, be simplified into an axisymmetric model. The piston and the cylinder liner do not have a perfect round shape, mainly due to machining tolerances and external thermo-mechanical loads. If the ring cannot follow the liner deformations, a local loss of contact occurs resulting in blow-by and increased consumption of lubricant oil in the engine. Current computational models are unable to implement such effects. The paper focuses on the development of a flexible 3D piston ring model based on the Timoshenko beam theory using the multibody system (MBS. The MBS model is compared to the finite element method (FEM solution.

  4. Laser Scanning Holographic Lithography for Flexible 3D Fabrication of Multi-Scale Integrated Nano-structures and Optical Biosensors.

    Science.gov (United States)

    Yuan, Liang Leon; Herman, Peter R

    2016-01-01

    Three-dimensional (3D) periodic nanostructures underpin a promising research direction on the frontiers of nanoscience and technology to generate advanced materials for exploiting novel photonic crystal (PC) and nanofluidic functionalities. However, formation of uniform and defect-free 3D periodic structures over large areas that can further integrate into multifunctional devices has remained a major challenge. Here, we introduce a laser scanning holographic method for 3D exposure in thick photoresist that combines the unique advantages of large area 3D holographic interference lithography (HIL) with the flexible patterning of laser direct writing to form both micro- and nano-structures in a single exposure step. Phase mask interference patterns accumulated over multiple overlapping scans are shown to stitch seamlessly and form uniform 3D nanostructure with beam size scaled to small 200 μm diameter. In this way, laser scanning is presented as a facile means to embed 3D PC structure within microfluidic channels for integration into an optofluidic lab-on-chip, demonstrating a new laser HIL writing approach for creating multi-scale integrated microsystems.

  5. Laser Scanning Holographic Lithography for Flexible 3D Fabrication of Multi-Scale Integrated Nano-structures and Optical Biosensors

    Science.gov (United States)

    Yuan, Liang (Leon); Herman, Peter R.

    2016-02-01

    Three-dimensional (3D) periodic nanostructures underpin a promising research direction on the frontiers of nanoscience and technology to generate advanced materials for exploiting novel photonic crystal (PC) and nanofluidic functionalities. However, formation of uniform and defect-free 3D periodic structures over large areas that can further integrate into multifunctional devices has remained a major challenge. Here, we introduce a laser scanning holographic method for 3D exposure in thick photoresist that combines the unique advantages of large area 3D holographic interference lithography (HIL) with the flexible patterning of laser direct writing to form both micro- and nano-structures in a single exposure step. Phase mask interference patterns accumulated over multiple overlapping scans are shown to stitch seamlessly and form uniform 3D nanostructure with beam size scaled to small 200 μm diameter. In this way, laser scanning is presented as a facile means to embed 3D PC structure within microfluidic channels for integration into an optofluidic lab-on-chip, demonstrating a new laser HIL writing approach for creating multi-scale integrated microsystems.

  6. Glasses for 3D ultrasound computer tomography: phase compensation

    Science.gov (United States)

    Zapf, M.; Hopp, T.; Ruiter, N. V.

    2016-03-01

    Ultrasound Computer Tomography (USCT), developed at KIT, is a promising new imaging system for breast cancer diagnosis, and was successfully tested in a pilot study. The 3D USCT II prototype consists of several hundreds of ultrasound (US) transducers on a semi-ellipsoidal aperture. Spherical waves are sequentially emitted by individual transducers and received in parallel by many transducers. Reflectivity volumes are reconstructed by synthetic aperture focusing (SAFT). However, straight forward SAFT imaging leads to blurred images due to system imperfections. We present an extension of a previously proposed approach to enhance the images. This approach includes additional a priori information and system characteristics. Now spatial phase compensation was included. The approach was evaluated with a simulation and clinical data sets. An increase in the image quality was observed and quantitatively measured by SNR and other metrics.

  7. Quantifying Multiscale Habitat Structural Complexity: A Cost-Effective Framework for Underwater 3D Modelling

    Directory of Open Access Journals (Sweden)

    Renata Ferrari

    2016-02-01

    Full Text Available Coral reef habitat structural complexity influences key ecological processes, ecosystem biodiversity, and resilience. Measuring structural complexity underwater is not trivial and researchers have been searching for accurate and cost-effective methods that can be applied across spatial extents for over 50 years. This study integrated a set of existing multi-view, image-processing algorithms, to accurately compute metrics of structural complexity (e.g., ratio of surface to planar area underwater solely from images. This framework resulted in accurate, high-speed 3D habitat reconstructions at scales ranging from small corals to reef-scapes (10s km2. Structural complexity was accurately quantified from both contemporary and historical image datasets across three spatial scales: (i branching coral colony (Acropora spp.; (ii reef area (400 m2; and (iii reef transect (2 km. At small scales, our method delivered models with <1 mm error over 90% of the surface area, while the accuracy at transect scale was 85.3% ± 6% (CI. Advantages are: no need for an a priori requirement for image size or resolution, no invasive techniques, cost-effectiveness, and utilization of existing imagery taken from off-the-shelf cameras (both monocular or stereo. This remote sensing method can be integrated to reef monitoring and improve our knowledge of key aspects of coral reef dynamics, from reef accretion to habitat provisioning and productivity, by measuring and up-scaling estimates of structural complexity.

  8. Protein 3D structure computed from evolutionary sequence variation.

    Directory of Open Access Journals (Sweden)

    Debora S Marks

    Full Text Available The evolutionary trajectory of a protein through sequence space is constrained by its function. Collections of sequence homologs record the outcomes of millions of evolutionary experiments in which the protein evolves according to these constraints. Deciphering the evolutionary record held in these sequences and exploiting it for predictive and engineering purposes presents a formidable challenge. The potential benefit of solving this challenge is amplified by the advent of inexpensive high-throughput genomic sequencing.In this paper we ask whether we can infer evolutionary constraints from a set of sequence homologs of a protein. The challenge is to distinguish true co-evolution couplings from the noisy set of observed correlations. We address this challenge using a maximum entropy model of the protein sequence, constrained by the statistics of the multiple sequence alignment, to infer residue pair couplings. Surprisingly, we find that the strength of these inferred couplings is an excellent predictor of residue-residue proximity in folded structures. Indeed, the top-scoring residue couplings are sufficiently accurate and well-distributed to define the 3D protein fold with remarkable accuracy.We quantify this observation by computing, from sequence alone, all-atom 3D structures of fifteen test proteins from different fold classes, ranging in size from 50 to 260 residues, including a G-protein coupled receptor. These blinded inferences are de novo, i.e., they do not use homology modeling or sequence-similar fragments from known structures. The co-evolution signals provide sufficient information to determine accurate 3D protein structure to 2.7-4.8 Å C(α-RMSD error relative to the observed structure, over at least two-thirds of the protein (method called EVfold, details at http://EVfold.org. This discovery provides insight into essential interactions constraining protein evolution and will facilitate a comprehensive survey of the universe of

  9. Computational and methodological developments towards 3D full waveform inversion

    Science.gov (United States)

    Etienne, V.; Virieux, J.; Hu, G.; Jia, Y.; Operto, S.

    2010-12-01

    Full waveform inversion (FWI) is one of the most promising techniques for seismic imaging. It relies on a formalism taking into account every piece of information contained in the seismic data as opposed to more classical techniques such as travel time tomography. As a result, FWI is a high resolution imaging process able to reach a spatial accuracy equal to half a wavelength. FWI is based on a local optimization scheme and therefore the main limitation concerns the starting model which has to be closed enough to the real one in order to converge to the global minimum. Another counterpart of FWI is the required computational resources when considering models and frequencies of interest. The task becomes even more tremendous when one tends to perform the inversion using the elastic equation instead of using the acoustic approximation. This is the reason why until recently most studies were limited to 2D cases. In the last few years, due to the increase of the available computational power, FWI has focused a lot of interests and continuous efforts towards inversion of 3D models, leading to remarkable applications up to the continental scale. We investigate the computational burden induced by FWI in 3D elastic media and propose some strategic features leading to the reduction of the numerical cost while providing a great flexibility in the inversion parametrization. First, in order to release the memory requirements, we developed our FWI algorithm in the frequency domain and take benefit of the wave-number redundancy in the seismic data to process a quite reduced number of frequencies. To do so, we extract frequency solutions from time marching techniques which are efficient for 3D structures. Moreover, this frequency approach permits a multi-resolution strategy by proceeding from low to high frequencies: the final model at one frequency is used as the starting model for the next frequency. This procedure overcomes partially the non-linear behavior of the inversion

  10. A distributed multiscale computation of a tightly coupled model using the Multiscale Modeling Language

    OpenAIRE

    Borgdorff, J.; Bona-Casas, C.; Mamonski, M.; Kurowski, K.; Piontek, T.; Bosak, B.; Rycerz, K.; Ciepiela, E.; Gubala, T.; Harezlak, D.; Bubak, M.; Lorenz, E.; Hoekstra, A.G.

    2012-01-01

    Nature is observed at all scales; with multiscale modeling, scientists bring together several scales for a holistic analysis of a phenomenon. The models on these different scales may require significant but also heterogeneous computational resources, creating the need for distributed multiscale computing. A particularly demanding type of multiscale models, tightly coupled, brings with it a number of theoretical and practical issues. In this contribution, a tightly coupled model of in-stent re...

  11. Interactive 3D computer model of the human corneolimbal region

    DEFF Research Database (Denmark)

    Molvaer, Rikke Kongshaug; Andreasen, Arne; Heegaard, Steffen;

    2013-01-01

    in the superior limbal region and one LEC, six LCs and 12 FSPs in the inferior limbal region. Only few LECs, LCs and FSPs were localized nasally and temporally. CONCLUSION: Interactive 3D models are a powerful tool that may help to shed more light on the existence and spatial localization of the different stem...... at low and high magnification, aligned, 3D reconstructed and visualized using interactive 3D visualization software. The visualization software has interactive tools that make free rotations in all directions possible and makes it possible to create virtual sections independent of the original cutting...... plan. In all, one low-magnification and 24 high-magnification interactive 3D models were created. Immunohistochemistry against stem cell markers p63 and ΔNp63α was performed as a supplement to the 3D models. RESULTS: Using the interactive 3D models, we identified three types of stem cell niches...

  12. Multiscale analysis of replication technique efficiency for 3D roughness characterization of manufactured surfaces

    Science.gov (United States)

    Jolivet, S.; Mezghani, S.; El Mansori, M.

    2016-09-01

    The replication of topography has been generally restricted to optimizing material processing technologies in terms of statistical and single-scale features such as roughness. By contrast, manufactured surface topography is highly complex, irregular, and multiscale. In this work, we have demonstrated the use of multiscale analysis on replicates of surface finish to assess the precise control of the finished replica. Five commercial resins used for surface replication were compared. The topography of five standard surfaces representative of common finishing processes were acquired both directly and by a replication technique. Then, they were characterized using the ISO 25178 standard and multiscale decomposition based on a continuous wavelet transform, to compare the roughness transfer quality at different scales. Additionally, atomic force microscope force modulation mode was used in order to compare the resins’ stiffness properties. The results showed that less stiff resins are able to replicate the surface finish along a larger wavelength band. The method was then tested for non-destructive quality control of automotive gear tooth surfaces.

  13. 3D Multiscale Integrated Modeling Approach of Complex Rock Mass Structures

    OpenAIRE

    Mingchao Li; Yanqing Han; Gang Wang; Fugen Yan

    2014-01-01

    Based on abundant geological data of different regions and different scales in hydraulic engineering, a new approach of 3D engineering-scale and statistical-scale integrated modeling was put forward, considering the complex relationships among geological structures and discontinuities and hydraulic structures. For engineering-scale geological structures, the 3D rock mass model of the study region was built by the exact match modeling method and the reliability analysis technique. For statisti...

  14. 3D Printing device adaptable to Computer Numerical Control (CNC)

    OpenAIRE

    Gardan, Julien; DANESI, Frédéric; Roucoules, Lionel; Schneider, A

    2014-01-01

    This article presents the development of a 3D printing device for the additive manufacturing adapted to a CNC machining. The application involves the integration of a specific printing head. Additive manufacturing technology is most commonly used for modeling, prototyping, tooling through an exclusive machine or 3D printer. A global review and analysis of technologies show the additive manufacturing presents little independent solutions [6][9]. The problem studied especially the additive manu...

  15. COMPUTER AIDED DESIGN IN URBAN ARHITECTURE 3D MODELING

    OpenAIRE

    Nicolae Radu MARSANU; Silvia Mihaela RUSU

    2010-01-01

    The gap from the PC made sketches with the help of the china ink pen and ruler to the digitised drawing boards, high diagonal monitors and 3D projecting is truly spectacular. The increasingly efficient and more specialized programs allow the architects a whole range of facilities providing drawing commands and changes very easy to use, automatic rating, operating simultaneously in multiple windows, building sections and extracts of the plan, 3D views design and even projecting in virtual real...

  16. A computational library for multiscale modeling of material failure

    Science.gov (United States)

    Talebi, Hossein; Silani, Mohammad; Bordas, Stéphane P. A.; Kerfriden, Pierre; Rabczuk, Timon

    2014-05-01

    We present an open-source software framework called PERMIX for multiscale modeling and simulation of fracture in solids. The framework is an object oriented open-source effort written primarily in Fortran 2003 standard with Fortran/C++ interfaces to a number of other libraries such as LAMMPS, ABAQUS, LS-DYNA and GMSH. Fracture on the continuum level is modeled by the extended finite element method (XFEM). Using several novel or state of the art methods, the piece software handles semi-concurrent multiscale methods as well as concurrent multiscale methods for fracture, coupling two continuum domains or atomistic domains to continuum domains, respectively. The efficiency of our open-source software is shown through several simulations including a 3D crack modeling in clay nanocomposites, a semi-concurrent FE-FE coupling, a 3D Arlequin multiscale example and an MD-XFEM coupling for dynamic crack propagation.

  17. 3D Multiscale Integrated Modeling Approach of Complex Rock Mass Structures

    Directory of Open Access Journals (Sweden)

    Mingchao Li

    2014-01-01

    Full Text Available Based on abundant geological data of different regions and different scales in hydraulic engineering, a new approach of 3D engineering-scale and statistical-scale integrated modeling was put forward, considering the complex relationships among geological structures and discontinuities and hydraulic structures. For engineering-scale geological structures, the 3D rock mass model of the study region was built by the exact match modeling method and the reliability analysis technique. For statistical-scale jointed rock mass, the random network simulation modeling method was realized, including Baecher structure plane model, Monte Carlo simulation, and dynamic check of random discontinuities, and the corresponding software program was developed. Finally, the refined model was reconstructed integrating with the engineering-scale model of rock structures, the statistical-scale model of discontinuities network, and the hydraulic structures model. It has been applied to the practical hydraulic project and offers the model basis for the analysis of hydraulic rock mass structures.

  18. Distributed multiscale computing with MUSCLE 2, the Multiscale Coupling Library and Environment

    NARCIS (Netherlands)

    J. Borgdorff; M. Mamonski; B. Bosak; K. Kurowski; M. Ben Belgacem; B. Chopard; D. Groen; P.V. Coveney; A.G. Hoekstra

    2014-01-01

    We present the Multiscale Coupling Library and Environment: MUSCLE 2. This multiscale component-based execution environment has a simple to use Java, C++, C, Python and Fortran API, compatible with MPI, OpenMP and threading codes. We demonstrate its local and distributed computing capabilities and c

  19. A distributed multiscale computation of a tightly coupled model using the Multiscale Modeling Language

    NARCIS (Netherlands)

    J. Borgdorff; C. Bona-Casas; M. Mamonski; K. Kurowski; T. Piontek; B. Bosak; K. Rycerz; E. Ciepiela; T. Gubala; D. Harezlak; M. Bubak; E. Lorenz; A.G. Hoekstra

    2012-01-01

    Nature is observed at all scales; with multiscale modeling, scientists bring together several scales for a holistic analysis of a phenomenon. The models on these different scales may require significant but also heterogeneous computational resources, creating the need for distributed multiscale comp

  20. A 3D Multiscale Modelling of Cortical Bone Structure, Using the Inverse Identification Method: Microfibril Scale Study

    CERN Document Server

    Barkaoui, Abdelwahed

    2011-01-01

    Complexity and heterogeneity of bone tissue require a multiscale modelling to understand their mechanical behaviour and their remodelling mechanism. Human cortical bone structure consists of six structural scale levels which are the (macroscopic) cortical bone, osteonal, lamellar, fibrous, fibril and microfibril. In this paper, a 3D model based on finite elements method was achieved to study the nanomechanical behaviour of collagen Microfibril. The mechanical properties and the geometry (gap, overlap and diameter) of both tropocollagen and mineral were taken into consideration as well as the effects of cross-links. An inverse identification method has been applied to determine equivalent averaged properties in order to link up these nanoscopic characteristics to the macroscopic mechanical behaviour of bone tissue. Results of nanostructure modelling of the nanomechanical properties of strain deformation under varying cross-links were investigated in this work.

  1. Multiscale modeling of mechanosensing channels on vesicles and cell membranes in 3D constricted flows and shear flows

    Science.gov (United States)

    Peng, Zhangli; Pak, On Shun; Young, Yuan-Nan; Liu, Allen; Stone, Howard

    2015-11-01

    We investigate the gating of mechanosensing channels (Mscls) on vesicles and cell membranes under different flow conditions using a multiscale approach. At the cell level (microns), the membrane tension is calculated using a 3D two-component whole-cell membrane model based on dissipative particle dynamics (DPD), including the cortex cytoskeleton and its interactions with the lipid bilayer. At the Mscl level (nanometers), we predict the relation between channel gating and the membrane tension obtained from a cell-level model using a semi-analytical model based on the bilayer hydrophobic mismatch energy. We systematically study the gating of Mscls of vesicles and cell membranes in constricted channel flows and shear flows, and explore the dependence of the gating on flow rate, cell shape and size. The results provide guidance for future experiments in inducing Mscl opening for various purposes such as drug delivery.

  2. 3D Visualization of Hydrological Model Outputs For a Better Understanding of Multi-Scale Phenomena

    Science.gov (United States)

    Richard, J.; Schertzer, D. J. M.; Tchiguirinskaia, I.

    2014-12-01

    During the last decades, many hydrological models has been created to simulate extreme events or scenarios on catchments. The classical outputs of these models are 2D maps, time series or graphs, which are easily understood by scientists, but not so much by many stakeholders, e.g. mayors or local authorities, and the general public. One goal of the Blue Green Dream project is to create outputs that are adequate for them. To reach this goal, we decided to convert most of the model outputs into a unique 3D visualization interface that combines all of them. This conversion has to be performed with an hydrological thinking to keep the information consistent with the context and the raw outputs.We focus our work on the conversion of the outputs of the Multi-Hydro (MH) model, which is physically based, fully distributed and with a GIS data interface. MH splits the urban water cycle into 4 components: the rainfall, the surface runoff, the infiltration and the drainage. To each of them, corresponds a modeling module with specific inputs and outputs. The superimposition of all this information will highlight the model outputs and help to verify the quality of the raw input data. For example, the spatial and the time variability of the rain generated by the rainfall module will be directly visible in 4D (3D + time) before running a full simulation. It is the same with the runoff module: because the result quality depends of the resolution of the rasterized land use, it will confirm or not the choice of the cell size.As most of the inputs and outputs are GIS files, two main conversions will be applied to display the results into 3D. First, a conversion from vector files to 3D objects. For example, buildings are defined in 2D inside a GIS vector file. Each polygon can be extruded with an height to create volumes. The principle is the same for the roads but an intrusion, instead of an extrusion, is done inside the topography file. The second main conversion is the raster

  3. Software-based geometry operations for 3D computer graphics

    NARCIS (Netherlands)

    Sima, M.; Iancu, D.; Glossner, J.; Schulte, M.; Mamidi, S.

    2006-01-01

    In order to support a broad dynamic range and a high degree of precision, many of 3D renderings fundamental algorithms have been traditionally performed in floating-point. However, fixed-point data representation is preferable over floatingpoint representation in graphics applications on embedded de

  4. From Digital to Physical: Computational Aspects of 3D Manufacturing

    OpenAIRE

    Baecher, Moritz Niklaus

    2013-01-01

    The desktop publishing revolution of the 1980s is currently repeating itself in 3D, referred to as desktop manufacturing. Online services such as Shapeways have become available, making personalized manufacturing on cutting edge additive manufacturing (AM) technologies accessible to a broad audience. Affordable desktop printers will soon take over, enabling people to fabricate

  5. Expression-robust 3D face recognition via weighted sparse representation of multi-scale and multi-component local normal patterns

    KAUST Repository

    Li, Huibin

    2014-06-01

    In the theory of differential geometry, surface normal, as a first order surface differential quantity, determines the orientation of a surface at each point and contains informative local surface shape information. To fully exploit this kind of information for 3D face recognition (FR), this paper proposes a novel highly discriminative facial shape descriptor, namely multi-scale and multi-component local normal patterns (MSMC-LNP). Given a normalized facial range image, three components of normal vectors are first estimated, leading to three normal component images. Then, each normal component image is encoded locally to local normal patterns (LNP) on different scales. To utilize spatial information of facial shape, each normal component image is divided into several patches, and their LNP histograms are computed and concatenated according to the facial configuration. Finally, each original facial surface is represented by a set of LNP histograms including both global and local cues. Moreover, to make the proposed solution robust to the variations of facial expressions, we propose to learn the weight of each local patch on a given encoding scale and normal component image. Based on the learned weights and the weighted LNP histograms, we formulate a weighted sparse representation-based classifier (W-SRC). In contrast to the overwhelming majority of 3D FR approaches which were only benchmarked on the FRGC v2.0 database, we carried out extensive experiments on the FRGC v2.0, Bosphorus, BU-3DFE and 3D-TEC databases, thus including 3D face data captured in different scenarios through various sensors and depicting in particular different challenges with respect to facial expressions. The experimental results show that the proposed approach consistently achieves competitive rank-one recognition rates on these databases despite their heterogeneous nature, and thereby demonstrates its effectiveness and its generalizability. © 2014 Elsevier B.V.

  6. Multiscale simulation of mixing processes using 3D-parallel, fluid-structure interaction techniques

    OpenAIRE

    Valette, Rudy; Vergnes, Bruno; Coupez, Thierry

    2008-01-01

    International audience This work focuses on the development of a general finite element code, called Ximex®, devoted to the three-dimensional direct simulation of mixing processes of complex fluids. The code is based on a simplified fictitious domain method coupled with a "level-set" approach to represent the rigid moving boundaries, such as screws and rotors, as well as free surfaces. These techniques, combined with the use of parallel computing, allow computing the time-dependent flow of...

  7. Multi-scale 3D simulation of lightning and thunderstorm electrodynamics

    Science.gov (United States)

    Kabirzadeh, R.; Lehtinen, N. G.; Liang, C.; Cohen, M.; Inan, U.

    2014-12-01

    Despite centuries studying thunderstorm electrodynamics, our understanding of these phenomena remains limited. The difficulty lies partly in the large number of processes and their mutual dependency and the wide range of temporal and the spatial scales involved. In this study we combine two numerical models to move toward a simulation that addresses these broad scales. First, we use a 3D numerical model to calculate the large scale quasi-electrostatic (QES) fields and charge distributions built up by updrafts in the thundercloud. This model self-consistently accounts for the conductivities, particle densities, large scale currents and charging mechanisms inside a thundercloud in the atmosphere. Second, we use a time-domain fractal lightning (TDFL) model developed that takes into account both the thermodynamics and electrodynamics of leader development and the return stroke on small time and spatial scales (Liang et al. 2014). The QES model simulates slow thunderstorm charging dynamics, and then passes the state to the TDFL model when a flash is ready to trigger. Using this combined simulation, we explain some recently observed patterns of lightning inside a thunderstorm and within a flash (e.g. Zoghzoghy et al. 2013, 2014). We attempt to constrain properties of the thundercloud like the size and shape of the charge pockets removed from the thundercloud, the flash rate and updraft currents, the relative occurrence rate of different types of lightning, and the cloud charge distribution structure effects on the lightning type.

  8. Computer-assisted three-dimensional surgical planning and simulation: 3D virtual osteotomy.

    Science.gov (United States)

    Xia, J; Ip, H H; Samman, N; Wang, D; Kot, C S; Yeung, R W; Tideman, H

    2000-02-01

    A computer-assisted three-dimensional virtual osteotomy system for orthognathic surgery (CAVOS) is presented. The virtual reality workbench is used for surgical planning. The surgeon immerses in a virtual reality environment with stereo eyewear, holds a virtual "scalpel" (3D Mouse) and operates on a "real" patient (3D visualization) to obtain pre-surgical prediction (3D bony segment movements). Virtual surgery on a computer-generated 3D head model is simulated and can be visualized from any arbitrary viewing point in a personal computer system.

  9. The 3d International Workshop on Computational Electronics

    Science.gov (United States)

    Goodnick, Stephen M.

    1994-09-01

    The Third International Workshop on Computational Electronics (IWCE) was held at the Benson Hotel in downtown Portland, Oregon, on May 18, 19, and 20, 1994. The workshop was devoted to a broad range of topics in computational electronics related to the simulation of electronic transport in semiconductors and semiconductor devices, particularly those which use large computational resources. The workshop was supported by the National Science Foundation (NSF), the Office of Naval Research and the Army Research Office, as well as local support from the Oregon Joint Graduate Schools of Engineering and the Oregon Center for Advanced Technology Education. There were over 100 participants in the Portland workshop, of which more than one quarter represented research groups outside of the United States from Austria, Canada, France, Germany, Italy, Japan, Switzerland, and the United Kingdom. There were a total 81 papers presented at the workshop, 9 invited talks, 26 oral presentations and 46 poster presentations. The emphasis of the contributions reflected the interdisciplinary nature of computational electronics with researchers from the Chemistry, Computer Science, Mathematics, Engineering, and Physics communities participating in the workshop.

  10. Multi-scale analysis of lung computed tomography images

    OpenAIRE

    Gori, I.; Bagagli, F.; Fantacci, M. E.; Martinez, A. Preite; Retico, A.; De Mitri, I.; Donadio, S.; Fulcheri, C.; Gargano, G; Magro, R.; Santoro, M; Stumbo, S

    2009-01-01

    A computer-aided detection (CAD) system for the identification of lung internal nodules in low-dose multi-detector helical Computed Tomography (CT) images was developed in the framework of the MAGIC-5 project. The three modules of our lung CAD system, a segmentation algorithm for lung internal region identification, a multi-scale dot-enhancement filter for nodule candidate selection and a multi-scale neural technique for false positive finding reduction, are described. The results obtained on...

  11. Computational 3-D Model of the Human Respiratory System

    Science.gov (United States)

    We are developing a comprehensive, morphologically-realistic computational model of the human respiratory system that can be used to study the inhalation, deposition, and clearance of contaminants, while being adaptable for age, race, gender, and health/disease status. The model ...

  12. Multi-scale uncertainty and sensitivity analysis of the TALL-3D experiment using thermal-hydraulic coupled codes

    International Nuclear Information System (INIS)

    The simulation of complex thermal-hydraulic phenomena is a challenging task. On one hand Computational Fluid Dynamics (CFD) codes allow a fine resolution of 3D phenomena but have a computational cost which is still prohibitive for some applications. On the other hand, System Analysis codes are fast running but cannot account for 3D phenomena. The coupling of these two approaches provides a tool which combines their advantages. In the context of the European THINS Project (7th Framework Program) the Gesellschaft für Anlagen- und Reaktorsicherheit mbH (GRS) developed a coupling between ANSYS CFX and ATHLET. The validation of this coupled code is to be performed with the help of experimental data provided by KTH (Sweden), which has built the TALL-3D facility for this purpose. This facility investigates the transition from forced to natural circulation of the Lead-Bismuth Eutectic (LBE) in a pool connected to a 3-leg primary circuit with two heaters and a heat exchanger. TUM is responsible for the Uncertainty and Sensitivity Analysis (USA) of the coupled ATHLET-CFX simulations in the THINS Project. The influence of modeling uncertainty on the simulation results needs to be assessed because it can significantly impair their accuracy. USA is a powerful tool to assess the model output variability resulting from modeling uncertainty (Uncertainty Analysis) and to identify and rank the influential model input parameters (Sensitivity Analysis). TUM has developed a computational framework to propagate modeling uncertainty through coupled Systems Analysis – Computational Fluid Dynamics (CFD) codes. This framework is being applied to the simulation of the experiments performed on the TALL-3D facility. The uncertainty methodology used is based on the statistical sampling of the uncertain inputs and models used by the two codes, its propagation through coupled calculations, and the final processing of the output sample of variables of interest with non-parametric statistical

  13. 3D neutron computed tomography. Requirements and applications

    International Nuclear Information System (INIS)

    Other than X-rays, neutrons can penetrate most metals easily while delivering a high contrast for many light-weight elements. Especially their high sensitivity for hydrogen makes them a valuable tool for the detection of organic materials like lubricants, plastics or sealants within metal housings. Neutron radiography and tomography complement the application of X-ray for the inspection of complex and critical components like in automotive and aerospace applications. An overview about the technical and mathematical differences between neutron and X-ray tomography is given and the imperfections and limitations of a neutron setup are shown. Several examples of technical neutron computed tomography are given. (author)

  14. Computation of Electrostatic Properties of 3D MEMS Structures

    CERN Document Server

    Majumdar, N

    2006-01-01

    Micro-Electro-Mechanical Systems (MEMS) normally have fixed or moving structures with cross-sections of the order of microns ($\\mu m$) and lengths of the order of tens or hundreds of microns. These structures are often plates or array of thin beams which, owing to their smallness, can be moved or deflected easily through the application of low voltages. Since electrostatic forces play a very major role in maneuvering these devices, a thorough understanding of the electrostatic properties of these structures is of critical importance, especially in the design phase of MEMS. In many cases, the electrostatic analysis of MEMS is carried out using boundary element method (BEM), while the structural analysis is carried out using finite element method (FEM). In this paper, we focus on accurate electrostatic analysis of MEMS using BEM. In particular, we consider the problem of computing the charge distribution and capacitance of thin conducting plates relevant to the numerical simulation of MEMS. The reason behind th...

  15. CudaPre3D: An Alternative Preprocessing Algorithm for Accelerating 3D Convex Hull Computation on the GPU

    Directory of Open Access Journals (Sweden)

    MEI, G.

    2015-05-01

    Full Text Available In the calculating of convex hulls for point sets, a preprocessing procedure that is to filter the input points by discarding non-extreme points is commonly used to improve the computational efficiency. We previously proposed a quite straightforward preprocessing approach for accelerating 2D convex hull computation on the GPU. In this paper, we extend that algorithm to being used in 3D cases. The basic ideas behind these two preprocessing algorithms are similar: first, several groups of extreme points are found according to the original set of input points and several rotated versions of the input set; then, a convex polyhedron is created using the found extreme points; and finally those interior points locating inside the formed convex polyhedron are discarded. Experimental results show that: when employing the proposed preprocessing algorithm, it achieves the speedups of about 4x on average and 5x to 6x in the best cases over the cases where the proposed approach is not used. In addition, more than 95 percent of the input points can be discarded in most experimental tests.

  16. 3D Computational Simulation of Calcium Leaching in Cement Matrices

    Directory of Open Access Journals (Sweden)

    Gaitero, J. J.

    2014-12-01

    Full Text Available Calcium leaching is a degradation process consisting in progressive dissolution of the cement paste by migration of calcium atoms to the aggressive solution. It is therefore, a complex phenomenon involving several phases and dissolution and diffusion processes simultaneously. Along this work, a new computational scheme for the simulation of the degradation process in three dimensions was developed and tested. The toolkit was used to simulate accelerated calcium leaching by a 6M ammonium nitrate solution in cement matrices. The obtained outputs were the three dimensional representation of the matrix and the physicochemical properties of individual phases as a consequence of the degradation process. This not only makes it possible to study the evolution of such properties as a function of time but also as a function of the position within the matrix. The obtained results are in good agreement with experimental values of the elastic modulus in degraded and undegraded samples.El lixiviado de calcio es un proceso de degradación consistente en la disolución progresiva de la pasta de cemento por la migración de los átomos de calcio a la disolución agresiva. Se trata por tanto de un fenómeno complejo que involucra simultáneamente diferentes fases y procesos de disolución y difusión. En este trabajo se desarrolló y probó una nueva herramienta computacional para la simulación del proceso de degradación en tres dimensiones. Para ello se simuló el lixiviado de calcio acelerado provocado por una disolución de nitrato amónico 6M en matrices de cemento. Como resultado se obtuvieron la representación tridimensional de la matriz y las propiedades físico-químicas sus fases a lo largo del tiempo. Esto permitió estudiar la evolución de dichas propiedades a lo largo del proceso de degradación así como en función de su posición dentro de la matriz. Los resultados obtenidos coinciden con los valores experimentales del módulo elástico tanto

  17. Practical limitations of cone-beam computed tomography in 3D cephalometry%Practical limitations of cone-beam computed tomography in3D cephalometry

    Institute of Scientific and Technical Information of China (English)

    Janalt Damstra; Zacharias Fourie; Yijin Ren

    2011-01-01

    3D cone beam computed tomography (CBCT) images offer a unique and new appreciation of the anatomical structures and underlying anomalies not possible with conventional radiographs.However,in almost all aspects of CBCT imaging,from utilization to application,inherent limitations and pitfalls exist.Importantly,these inherent limitations and pitfalls have practical implications which need to be addressed before the potential of this technology can be fully realized.The purpose of this review was to explore the current limitations and pitfalls associated with CBCT imaging to allow for better and more accurate understanding of the possibilities this imaging modality could offer,particularly pertaining to 3D cephalometry.

  18. Effect of coordinate rotation on 3D molecular descriptors computed by DragonX

    CERN Document Server

    Hechinger, Manuel

    2012-01-01

    Quantitative structure-property relations (QSPR) employing descriptors derived from the 3D molecular structure are frequently applied for property prediction in various fields of research. In particular, DragonX is one of the most widely used software packages for descriptor calculation. The reliability of 3D molecular descriptors computed by DragonX has lately been investigated, thereby focusing on the effect of computational methods used for molecular structure optimization on the accuracy of the resulting molecular descriptors. The present contribution extends the analysis to a more intrinsic problem of DragonX descriptor evaluation resulting from the sensitivity of the computed 3D descriptors on the coordinate system used for molecule description. Evaluating several 3D descriptors for converged molecular structures rotated around all 3 spatial axes (affine coordinate transformations) yields systematically varying descriptor values. Since this unphysical behavior severely affects the descriptor reliability...

  19. An Approach to Computer Modeling of Geological Faults in 3D and an Application

    Institute of Scientific and Technical Information of China (English)

    ZHU Liang-feng; HE Zheng; PAN Xin; WU Xin-cai

    2006-01-01

    3D geological modeling, one of the most important applications in geosciences of 3D GIS, forms the basis and is a prerequisite for visualized representation and analysis of 3D geological data. Computer modeling of geological faults in 3D is currently a topical research area. Structural modeling techniques of complex geological entities containing reverse faults are discussed and a series of approaches are proposed. The geological concepts involved in computer modeling and visualization of geological fault in 3D are explained, the type of data of geological faults based on geological exploration is analyzed, and a normative database format for geological faults is designed. Two kinds of modeling approaches for faults are compared: a modeling technique of faults based on stratum recovery and a modeling technique of faults based on interpolation in subareas. A novel approach, called the Unified Modeling Technique for stratum and fault, is presented to solve the puzzling problems of reverse faults, syn-sedimentary faults and faults terminated within geological models. A case study of a fault model of bed rock in the Beijing Olympic Green District is presented in order to show the practical result of this method. The principle and the process of computer modeling of geological faults in 3D are discussed and a series of applied technical proposals established. It strengthens our profound comprehension of geological phenomena and the modeling approach, and establishes the basic techniques of 3D geological modeling for practical applications in the field of geosciences.

  20. Distributed multiscale computing with MUSCLE 2, the Multiscale Coupling Library and Environment

    OpenAIRE

    Borgdorff, J.; Mamonski, M.; Bosak, B.; Kurowski, K.; Ben Belgacem, M.; Chopard, B.; Groen, D; Coveney, P. V.; Hoekstra, A.G.

    2014-01-01

    We present the Multiscale Coupling Library and Environment: MUSCLE 2. This multiscale component-based execution environment has a simple to use Java, C++, C, Python and Fortran API, compatible with MPI, OpenMP and threading codes. We demonstrate its local and distributed computing capabilities and compare its performance to MUSCLE 1, file copy, MPI, MPWide, and GridFTP. The local throughput of MPI is about two times higher, so very tightly coupled code should use MPI as a single submodel of M...

  1. Assembly of a 3D Cellular Computer Using Folded E-Blocks

    Directory of Open Access Journals (Sweden)

    Shivendra Pandey

    2016-04-01

    Full Text Available The assembly of integrated circuits in three dimensions (3D provides a possible solution to address the ever-increasing demands of modern day electronic devices. It has been suggested that by using the third dimension, devices with high density, defect tolerance, short interconnects and small overall form factors could be created. However, apart from pseudo 3D architecture, such as monolithic integration, die, or wafer stacking, the creation of paradigms to integrate electronic low-complexity cellular building blocks in architecture that has tile space in all three dimensions has remained elusive. Here, we present software and hardware foundations for a truly 3D cellular computational devices that could be realized in practice. The computing architecture relies on the scalable, self-configurable and defect-tolerant cell matrix. The hardware is based on a scalable and manufacturable approach for 3D assembly using folded polyhedral electronic blocks (E-blocks. We created monomers, dimers and 2 × 2 × 2 assemblies of polyhedral E-blocks and verified the computational capabilities by implementing simple logic functions. We further show that 63.2% more compact 3D circuits can be obtained with our design automation tools compared to a 2D architecture. Our results provide a proof-of-concept for a scalable and manufacture-ready process for constructing massive-scale 3D computational devices.

  2. 3D Terrestrial LiDAR data classification of complex natural scenes using a multi-scale dimensionality criterion: applications in geomorphology

    CERN Document Server

    Brodu, Nicolas

    2011-01-01

    3D point clouds of natural environments relevant to geomorphology problems (rivers, cliffs...) often require to classify the data into elementary relevant classes. A typical example is the separation of riparian vegetation from soil in fluvial environments, the distinction between fresh surfaces and rockfall in cliff environments, or more generally the classification of surfaces according to their morphology (ripples, grain size...). Natural surfaces are very heterogeneous and their distinctive properties are seldom defined at a unique scale. We have thus defined a multi-scale measure of the point cloud dimensionality around each point. The dimensionality characterizes the local 3D organization of the point cloud and varies from being 1D (points set along a line) to really taking all 3D volume, at each scale. We present the technique and illustrate its efficiency in separating riparian vegetation from ground and classifying a mountain stream in vegetation, rock, gravel and water surface. The superiority of th...

  3. Multi-scale analysis of lung computed tomography images

    CERN Document Server

    Gori, I; Fantacci, M E; Martinez, A Preite; Retico, A; De Mitri, I; Donadio, S; Fulcheri, C; Gargano, G; Magro, R; Santoro, M; Stumbo, S; 10.1088/1748-0221/2/09/P09007

    2009-01-01

    A computer-aided detection (CAD) system for the identification of lung internal nodules in low-dose multi-detector helical Computed Tomography (CT) images was developed in the framework of the MAGIC-5 project. The three modules of our lung CAD system, a segmentation algorithm for lung internal region identification, a multi-scale dot-enhancement filter for nodule candidate selection and a multi-scale neural technique for false positive finding reduction, are described. The results obtained on a dataset of low-dose and thin-slice CT scans are shown in terms of free response receiver operating characteristic (FROC) curves and discussed.

  4. Multi-scale analysis of lung computed tomography images

    CERN Document Server

    Gori, I; Fantacci, M E; Preite Martinez, A; Retico, A; De Mitri, I; Donadio, S; Fulcheri, C

    2007-01-01

    A computer-aided detection (CAD) system for the identification of lung internal nodules in low-dose multi-detector helical Computed Tomography (CT) images was developed in the framework of the MAGIC-5 project. The three modules of our lung CAD system, a segmentation algorithm for lung internal region identification, a multi-scale dot-enhancement filter for nodule candidate selection and a multi-scale neural technique for false positive finding reduction, are described. The results obtained on a dataset of low-dose and thin-slice CT scans are shown in terms of free response receiver operating characteristic (FROC) curves and discussed.

  5. Computer-Designed Splints for Surgical Transfer of 3D Orthognathic Planning.

    Science.gov (United States)

    Zinser, Max; Zoeller, Joachim

    2015-10-01

    Advances in computers and imaging have permitted the adoption of three-dimensional (3D) planning protocols in orthognathic surgery, which may allow a paradigm shift when the computer-assisted planning can be transferred properly. The purpose of this investigation was to introduce an innovative clinical protocol using computer-aided designed and computer-aided manufactured (CAD/CAM) surgical splints for surgical transfer of 3D orthognathic planning compared with the classic technique using arbitrary occlusal splints. The clinical protocols consisted of computed tomography (CT) or cone-beam CT (CBCT) maxillofacial imaging, bone segmentation, 3D diagnosis, computer-assisted surgical treatment planning, and CAD/CAM surgical splints (group A) and manufacture of arbitrary occlusal splints (group B) for intraoperative surgical planning transfer. The observed patients underwent bimaxillary osteotomies and, if necessary, an additional genioplasty. Both techniques were evaluated by applying 13 hard tissue parameters to compare the 3D orthognathic planning (T0) with the postoperative result (T1) using 3D cephalometry. The CAD/CAM splints showed significant better precision for the maxilla (ΔT orthognathic planning, which is more precise compared with the conventional arbitrary occlusal splints.

  6. Final technical report for DOE Computational Nanoscience Project: Integrated Multiscale Modeling of Molecular Computing Devices

    Energy Technology Data Exchange (ETDEWEB)

    Cummings, P. T.

    2010-02-08

    This document reports the outcomes of the Computational Nanoscience Project, "Integrated Multiscale Modeling of Molecular Computing Devices". It includes a list of participants and publications arising from the research supported.

  7. 3D SPIRAL COMPUTED TOMOGRAPHY FOR THE DIAGNOSIS OF AN ABDOMINAL TUMOUR

    OpenAIRE

    R.C. Tiutiuca; Iuliana Eva

    2006-01-01

    Patients with digestive illnesses requires a full exploration, cases where imagistic assets support (echographic examination, radiological data, computed tomography, magnetic resonance) are very usefully. Computed tomography, in this process, has a special value. The results from axial images are sustained by the informations supplied from three-dimensional reconstruction processes (3D reconstruction) with relevant importance in establishment of diagnosis and therapeutic plan.

  8. Ground truth evaluation of computer vision based 3D reconstruction of synthesized and real plant images

    DEFF Research Database (Denmark)

    Nielsen, Michael; Andersen, Hans Jørgen; Slaughter, David;

    2007-01-01

    There is an increasing interest in using 3D computer vision in precision agriculture. This calls for better quantitative evaluation and understanding of computer vision methods. This paper proposes a test framework using ray traced crop scenes that allows in-depth analysis of algorithm performanc...

  9. 3D-SoftChip: A Novel Architecture for Next-Generation Adaptive Computing Systems

    Directory of Open Access Journals (Sweden)

    Lee Mike Myung-Ok

    2006-01-01

    Full Text Available This paper introduces a novel architecture for next-generation adaptive computing systems, which we term 3D-SoftChip. The 3D-SoftChip is a 3-dimensional (3D vertically integrated adaptive computing system combining state-of-the-art processing and 3D interconnection technology. It comprises the vertical integration of two chips (a configurable array processor and an intelligent configurable switch through an indium bump interconnection array (IBIA. The configurable array processor (CAP is an array of heterogeneous processing elements (PEs, while the intelligent configurable switch (ICS comprises a switch block, 32-bit dedicated RISC processor for control, on-chip program/data memory, data frame buffer, along with a direct memory access (DMA controller. This paper introduces the novel 3D-SoftChip architecture for real-time communication and multimedia signal processing as a next-generation computing system. The paper further describes the advanced HW/SW codesign and verification methodology, including high-level system modeling of the 3D-SoftChip using SystemC, being used to determine the optimum hardware specification in the early design stage.

  10. 3D COMPUTER SIMULATION FOR LIGNIFICATION OF ANCIENT CHINESE TIMBER BUILDINGS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A pioneer research work was carried out by investigators engaged in surveying and mapping for describing ancient Chinese timber buildings by 3D frame graphs w ith a computer.Users can know the structural layers and the assembly process of the se buildings if the frame graphs are processed further with a computer model.Th is can be implemented by computer simulation technique.This technique display t he raw data on the screen of a computer and interactively manage them by combini ng technologies from computer graphics and image processing,multi-media technol ogy,artificial intelligence,highly parallel real-time computation technique an d human behavior science.This paper presents the implementing procedure of ligni fi cation simulation for large-sized wooden buildings as well as 3D dynamic assembl y of these buildings under the 3DS MAX environment.The results from computer sim ulation are also shown in the paper.

  11. Computer-aided microtomography with true 3-D display in electron microscopy.

    Science.gov (United States)

    Nelson, A C

    1986-01-01

    A novel research system has been designed to permit three-dimensional (3-D) viewing of high resolution image data from transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The system consists of front-end primary data acquisition devices, such as TEM and SEM machines, which are equipped with computer-controlled specimen tilt stages. The output from these machines is in analogue form, where a video camera attached to the TEM provides the sequential analogue image output while the SEM direct video output is utilized. A 10 MHz digitizer transforms the video image to a digital array of 512 X 512 pixel units of 8 bits deep-stored in a frame buffer. Digital images from multiple projections are reconstructed into 3-D image boxes in a dedicated computer. Attached to the computer is a powerful true 3-D display device which has hardware for graphic manipulations including tilt and rotate on any axis and for probing the image with a 3-D cursor. Data editing and automatic contouring functions are used to enhance areas of interest, and specialized software is available for measurement of numbers, distances, areas, and volumes. With proper archiving of reconstructed image sequences, a dynamic 3-D presentation is possible. The microtomography system is highly versatile and can process image data on-line or from remote sites from which data records would typically be transported on computer tape, video tape, or floppy disk. PMID:3753610

  12. Enhancement of 3D modeling and classification of microcalcifications in breast computed tomography (BCT)

    Science.gov (United States)

    Alquran, Hiam; Shaheen, Eman; O'Connor, J. Michael; Mahd, Mufeed

    2014-03-01

    Current computer aided diagnosis (CADx) software for digital mammography relies mainly on 2D techniques. With the emergence of three-dimensional (3D) breast imaging modalities such as breast Computed Tomography (BCT), there is an opportunity to analyze 3D features in the classification of calcifications. We previously reported our initial work on automated 3D feature detection and classification based on morphological descriptions for single microcalcifications within clusters [1]. In this work, we propose the expansion of the 3D classification methods to include novel microcalcification morphological feature detection such as including more morphological classes and replacing the 2D Radon transform by a 3D Radon transform. Results show that the classification rate improved compared to the previously reported results from a total of 546 to 559 consistently classified calcifications out of 635 total calcifications. This slight improvement is due to the use of the 3D Radon transform and incorporating methods to detect two classes not previously implemented. Future work will focus on adding feature detection and classification of cluster patterns.

  13. Meta!Blast computer game: a pipeline from science to 3D art to education

    Science.gov (United States)

    Schneller, William; Campbell, P. J.; Bassham, Diane; Wurtele, Eve Syrkin

    2012-03-01

    Meta!Blast (http://www.metablast.org) is designed to address the challenges students often encounter in understanding cell and metabolic biology. Developed by faculty and students in biology, biochemistry, computer science, game design, pedagogy, art and story, Meta!Blast is being created using Maya (http://usa.autodesk.com/maya/) and the Unity 3D (http://unity3d.com/) game engine, for Macs and PCs in classrooms; it has also been exhibited in an immersive environment. Here, we describe the pipeline from protein structural data and holographic information to art to the threedimensional (3D) environment to the game engine, by which we provide a publicly-available interactive 3D cellular world that mimics a photosynthetic plant cell.

  14. Efficient computation of steady, 3D water-wave patterns, application to hovercraft-type flows

    OpenAIRE

    Lewis, M. R.; Koren, Barry

    2002-01-01

    Numerical methods for the computation of stationary free surfaces is the subject of much current research in computational engineering. The present report is directed towards free surfaces in maritime engineering. Of interest here are the long steady waves generated by hovercraft and ships, the gravity waves. In the present report an existing 2D iterative method for the computation of stationary gravity-wave solutions is extended to 3D, numerically investigated, and improved. The method emplo...

  15. Multiscale modeling of complex materials phenomenological, theoretical and computational aspects

    CERN Document Server

    Trovalusci, Patrizia

    2014-01-01

    The papers in this volume deal with materials science, theoretical mechanics and experimental and computational techniques at multiple scales, providing a sound base and a framework for many applications which are hitherto treated in a phenomenological sense. The basic principles are formulated of multiscale modeling strategies towards modern complex multiphase materials subjected to various types of mechanical, thermal loadings and environmental effects. The focus is on problems where mechanics is highly coupled with other concurrent physical phenomena. Attention is also focused on the historical origins of multiscale modeling and foundations of continuum mechanics currently adopted to model non-classical continua with substructure, for which internal length scales play a crucial role.

  16. 3-D Multiphase Segmentation of X-Ray Micro Computed Tomography Data of Geologic Materials

    Science.gov (United States)

    Tuller, M.; Kulkarni, R.; Fink, W.

    2011-12-01

    Advancements of noninvasive imaging methods such as X-Ray Computed Tomography (CT) led to a recent surge of applications in Geoscience. While substantial efforts and resources have been devoted to advance CT technology and micro-scale analysis, the development of a stable 3-D multiphase image segmentation method applicable to large datasets is lacking. To eliminate the need for wet/dry or dual energy scans, image alignment, and subtraction analysis, commonly applied in synchrotron X-Ray micro CT, a segmentation method based on a Bayesian Markov Random Field (MRF) framework amenable to true 3-D multiphase processing was developed and evaluated. Furthermore, several heuristic and deterministic combinatorial optimization schemes required to solve the labeling problem of the MRF image model were implemented and tested for computational efficiency and their impact on segmentation results. Test results for natural and artificial porous media datasets demonstrate great potential of the MRF image model for 3-D multiphase segmentation.

  17. Computer-Assisted Hepatocellular Carcinoma Ablation Planning Based on 3-D Ultrasound Imaging.

    Science.gov (United States)

    Li, Kai; Su, Zhongzhen; Xu, Erjiao; Guan, Peishan; Li, Liu-Jun; Zheng, Rongqin

    2016-08-01

    To evaluate computer-assisted hepatocellular carcinoma (HCC) ablation planning based on 3-D ultrasound, 3-D ultrasound images of 60 HCC lesions from 58 patients were obtained and transferred to a research toolkit. Compared with virtual manual ablation planning (MAP), virtual computer-assisted ablation planning (CAP) consumed less time and needle insertion numbers and exhibited a higher rate of complete tumor coverage and lower rate of critical structure injury. In MAP, junior operators used less time, but had more critical structure injury than senior operators. For large lesions, CAP performed better than MAP. For lesions near critical structures, CAP resulted in better outcomes than MAP. Compared with MAP, CAP based on 3-D ultrasound imaging was more effective and achieved a higher rate of complete tumor coverage and a lower rate of critical structure injury; it is especially useful for junior operators and with large lesions, and lesions near critical structures. PMID:27126243

  18. Novel fully integrated computer system for custom footwear: from 3D digitization to manufacturing

    Science.gov (United States)

    Houle, Pascal-Simon; Beaulieu, Eric; Liu, Zhaoheng

    1998-03-01

    This paper presents a recently developed custom footwear system, which integrates 3D digitization technology, range image fusion techniques, a 3D graphical environment for corrective actions, parametric curved surface representation and computer numerical control (CNC) machining. In this system, a support designed with the help of biomechanics experts can stabilize the foot in a correct and neutral position. The foot surface is then captured by a 3D camera using active ranging techniques. A software using a library of documented foot pathologies suggests corrective actions on the orthosis. Three kinds of deformations can be achieved. The first method uses previously scanned pad surfaces by our 3D scanner, which can be easily mapped onto the foot surface to locally modify the surface shape. The second kind of deformation is construction of B-Spline surfaces by manipulating control points and modifying knot vectors in a 3D graphical environment to build desired deformation. The last one is a manual electronic 3D pen, which may be of different shapes and sizes, and has an adjustable 'pressure' information. All applied deformations should respect a G1 surface continuity, which ensure that the surface can accustom a foot. Once the surface modification process is completed, the resulting data is sent to manufacturing software for CNC machining.

  19. Practical limitations of cone-beam computed tomography in 3D cephalometry

    NARCIS (Netherlands)

    Damstra, Janalt; Fourie, Zacharias; Ren, Yijin

    2011-01-01

    3D cone beam computed tomography (CBCT) images offer a unique and new appreciation of the anatomical structures and underlying anomalies not possible with conventional radiographs. However, in almost all aspects of CBCT imaging, from utilization to application, inherent limitations and pitfalls exis

  20. The Effects of 3D Computer Simulation on Biology Students' Achievement and Memory Retention

    Science.gov (United States)

    Elangovan, Tavasuria; Ismail, Zurida

    2014-01-01

    A quasi experimental study was conducted for six weeks to determine the effectiveness of two different 3D computer simulation based teaching methods, that is, realistic simulation and non-realistic simulation on Form Four Biology students' achievement and memory retention in Perak, Malaysia. A sample of 136 Form Four Biology students in Perak,…

  1. Computer assisted determination of acetabular cup orientation using 2D-3D image registration

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Guoyan; Zhang, Xuan [University of Bern, Institute for Surgical Technology and Biomechanics, Bern (Switzerland)

    2010-09-15

    2D-3D image-based registration methods have been developed to measure acetabular cup orientation after total hip arthroplasty (THA). These methods require registration of both the prosthesis and the CT images to 2D radiographs and compute implant position with respect to a reference. The application of these methods is limited in clinical practice due to two limitations: (1) the requirement of a computer-aided design (CAD) model of the prosthesis, which may be unavailable due to the proprietary concerns of the manufacturer, and (2) the requirement of either multiple radiographs or radiograph-specific calibration, usually unavailable for retrospective studies. In this paper, we propose a new method to address these limitations. A new formulation for determination of post-operative cup orientation, which couples a radiographic measurement with 2D-3D image matching, was developed. In our formulation, the radiographic measurement can be obtained with known methods so that the challenge lies in the 2D-3D image matching. To solve this problem, a hybrid 2D-3D registration scheme combining a landmark-to-ray 2D-3D alignment with a robust intensity-based 2D-3D registration was used. The hybrid 2D-3D registration scheme allows computing both the post-operative cup orientation with respect to an anatomical reference and the pelvic tilt and rotation with respect to the X-ray imaging table/plate. The method was validated using 2D adult cadaver hips. Using the hybrid 2D-3D registration scheme, our method showed a mean accuracy of 1.0 {+-} 0.7 (range from 0.1 to 2.0 ) for inclination and 1.7 {+-} 1.2 (range from 0.0 to 3.9 ) for anteversion, taking the measurements from post-operative CT images as ground truths. Our new solution formulation and the hybrid 2D-3D registration scheme facilitate estimation of post-operative cup orientation and measurement of pelvic tilt and rotation. (orig.)

  2. Biotemplate synthesis of polyaniline@cellulose nanowhiskers/natural rubber nanocomposites with 3D hierarchical multiscale structure and improved electrical conductivity.

    Science.gov (United States)

    Wu, Xiaodong; Lu, Canhui; Xu, Haoyu; Zhang, Xinxing; Zhou, Zehang

    2014-12-10

    Development of novel and versatile strategies to construct conductive polymer composites with low percolation thresholds and high mechanical properties is of great importance. In this work, we report a facile and effective strategy to prepare polyaniline@cellulose nanowhiskers (PANI@CNs)/natural rubber (NR) nanocomposites with 3D hierarchical multiscale structure. Specifically, PANI was synthesized in situ on the surface of CNs biotemplate to form PANI@CNs nanohybrids with high aspect ratio and good dispersity. Then NR latex was introduced into PANI@CNs nanohybrids suspension to enable the self-assembly of PANI@CNs nanohybrids onto NR latex microspheres. During cocoagulation process, PANI@CNs nanohybrids selectively located in the interstitial space between NR microspheres and organized into a 3D hierarchical multiscale conductive network structure in NR matrix. The combination of the biotemplate synthesis of PANI and latex cocoagulation method significantly enhanced the electrical conductivity and mechanical properties of the NR-based nanocomposites simultaneously. The electrical conductivity of PANI@CNs/NR nanocomposites containing 5 phr PANI showed 11 orders of magnitude higher than that of the PANI/NR composites at the same loading fraction,; meanwhile, the percolation threshold was drastically decreased from 8.0 to 3.6 vol %.

  3. Biotemplate synthesis of polyaniline@cellulose nanowhiskers/natural rubber nanocomposites with 3D hierarchical multiscale structure and improved electrical conductivity.

    Science.gov (United States)

    Wu, Xiaodong; Lu, Canhui; Xu, Haoyu; Zhang, Xinxing; Zhou, Zehang

    2014-12-10

    Development of novel and versatile strategies to construct conductive polymer composites with low percolation thresholds and high mechanical properties is of great importance. In this work, we report a facile and effective strategy to prepare polyaniline@cellulose nanowhiskers (PANI@CNs)/natural rubber (NR) nanocomposites with 3D hierarchical multiscale structure. Specifically, PANI was synthesized in situ on the surface of CNs biotemplate to form PANI@CNs nanohybrids with high aspect ratio and good dispersity. Then NR latex was introduced into PANI@CNs nanohybrids suspension to enable the self-assembly of PANI@CNs nanohybrids onto NR latex microspheres. During cocoagulation process, PANI@CNs nanohybrids selectively located in the interstitial space between NR microspheres and organized into a 3D hierarchical multiscale conductive network structure in NR matrix. The combination of the biotemplate synthesis of PANI and latex cocoagulation method significantly enhanced the electrical conductivity and mechanical properties of the NR-based nanocomposites simultaneously. The electrical conductivity of PANI@CNs/NR nanocomposites containing 5 phr PANI showed 11 orders of magnitude higher than that of the PANI/NR composites at the same loading fraction,; meanwhile, the percolation threshold was drastically decreased from 8.0 to 3.6 vol %. PMID:25384188

  4. Histomorphometric quantification of human pathological bones from synchrotron radiation 3D computed microtomography

    International Nuclear Information System (INIS)

    Conventional bone histomorphometry is an important method for quantitative evaluation of bone microstructure. X-ray computed microtomography is a noninvasive technique, which can be used to evaluate histomorphometric indices in trabecular bones (BV/TV, BS/BV, Tb.N, Tb.Th, Tb.Sp). In this technique, the output 3D images are used to quantify the whole sample, differently from the conventional one, in which the quantification is performed in 2D slices and extrapolated for 3D case. In this work, histomorphometric quantification using synchrotron 3D X-ray computed microtomography was performed to quantify pathological samples of human bone. Samples of human bones were cut into small blocks (8 mm x 8 mm x 10 mm) with a precision saw and then imaged. The computed microtomographies were obtained at SYRMEP (Synchrotron Radiation for MEdical Physics) beamline, at ELETTRA synchrotron radiation facility (Italy). The obtained 3D images yielded excellent resolution and details of intra-trabecular bone structures, including marrow present inside trabeculae. Histomorphometric quantification was compared to literature as well. (author)

  5. Using the CAVE virtual-reality environment as an aid to 3-D electromagnetic field computation

    International Nuclear Information System (INIS)

    One of the major problems in three-dimensional (3-D) field computation is visualizing the resulting 3-D field distributions. A virtual-reality environment, such as the CAVE, (CAVE Automatic Virtual Environment) is helping to overcome this problem, thus making the results of computation more usable for designers and users of magnets and other electromagnetic devices. As a demonstration of the capabilities of the CAVE, the elliptical multipole wiggler (EMW), an insertion device being designed for the Advanced Photon Source (APS) now being commissioned at Argonne National Laboratory (ANL), wa made visible, along with its fields and beam orbits. Other uses of the CAVE in preprocessing and postprocessing computation for electromagnetic applications are also discussed

  6. Multiscale methods for computational RNA enzymology

    Science.gov (United States)

    Panteva, Maria T.; Dissanayake, Thakshila; Chen, Haoyuan; Radak, Brian K.; Kuechler, Erich R.; Giambaşu, George M.; Lee, Tai-Sung; York, Darrin M.

    2016-01-01

    RNA catalysis is of fundamental importance to biology and yet remains ill-understood due to its complex nature. The multi-dimensional “problem space” of RNA catalysis includes both local and global conformational rearrangements, changes in the ion atmosphere around nucleic acids and metal ion binding, dependence on potentially correlated protonation states of key residues and bond breaking/forming in the chemical steps of the reaction. The goal of this article is to summarize and apply multiscale modeling methods in an effort to target the different parts of the RNA catalysis problem space while also addressing the limitations and pitfalls of these methods. Classical molecular dynamics (MD) simulations, reference interaction site model (RISM) calculations, constant pH molecular dynamics (CpHMD) simulations, Hamiltonian replica exchange molecular dynamics (HREMD) and quantum mechanical/molecular mechanical (QM/MM) simulations will be discussed in the context of the study of RNA backbone cleavage transesterification. This reaction is catalyzed by both RNA and protein enzymes, and here we examine the different mechanistic strategies taken by the hepatitis delta virus ribozyme (HDVr) and RNase A. PMID:25726472

  7. Population Estimation Using a 3D City Model: A Multi-Scale Country-Wide Study in the Netherlands.

    Science.gov (United States)

    Biljecki, Filip; Arroyo Ohori, Ken; Ledoux, Hugo; Peters, Ravi; Stoter, Jantien

    2016-01-01

    The remote estimation of a region's population has for decades been a key application of geographic information science in demography. Most studies have used 2D data (maps, satellite imagery) to estimate population avoiding field surveys and questionnaires. As the availability of semantic 3D city models is constantly increasing, we investigate to what extent they can be used for the same purpose. Based on the assumption that housing space is a proxy for the number of its residents, we use two methods to estimate the population with 3D city models in two directions: (1) disaggregation (areal interpolation) to estimate the population of small administrative entities (e.g. neighbourhoods) from that of larger ones (e.g. municipalities); and (2) a statistical modelling approach to estimate the population of large entities from a sample composed of their smaller ones (e.g. one acquired by a government register). Starting from a complete Dutch census dataset at the neighbourhood level and a 3D model of all 9.9 million buildings in the Netherlands, we compare the population estimates obtained by both methods with the actual population as reported in the census, and use it to evaluate the quality that can be achieved by estimations at different administrative levels. We also analyse how the volume-based estimation enabled by 3D city models fares in comparison to 2D methods using building footprints and floor areas, as well as how it is affected by different levels of semantic detail in a 3D city model. We conclude that 3D city models are useful for estimations of large areas (e.g. for a country), and that the 3D approach has clear advantages over the 2D approach. PMID:27254151

  8. 多比例尺下的三维GIS细节层次可视化技术%Visualization with Level of Dettail at Multi-Scale in 3D G1S

    Institute of Scientific and Technical Information of China (English)

    李军; 景宁; 孙茂印

    2000-01-01

    In this paper.by investigating leve of detail in 3D GIS,we integrate generalization techniques with 3D visualization techniques on the basis of object oriented database. In order to improve the perfornuance of database access,we investigate thc access structure based on modified reactive tree and analyze the detailed method of representing level of detail. This approach visualizes 3D object with object-oriented database and integrates generalization with 3D visuahzation techniques,3D GIS is expected to achieve etter performance of query and photo-realistic visualization at multi-scale.

  9. A Computer Vision Method for 3D Reconstruction of Curves-Marked Free-Form Surfaces

    Institute of Scientific and Technical Information of China (English)

    Xiong Hanwei; Zhang Xiangwei

    2001-01-01

    Visual method is now broadly used in reverse engineering for 3D reconstruction. Thetraditional computer vision methods are feature-based, i.e., they require that the objects must revealfeatures owing to geometry or textures. For textureless free-form surfaces, dense feature points areadded artificially. In this paper, a new method is put forward combining computer vision with CAGD.The surface is subdivided into N-side Gregory patches using marked curves, and a stereo algorithm isused to reconstruct the curves. Then, the cross boundary tangent vector is computed throughreflectance analysis. At last, the whole surface can be reconstructed by jointing these patches withG1 continuity.

  10. Multiscale computer modeling in biomechanics and biomedical engineering

    CERN Document Server

    2013-01-01

    This book reviews the state-of-the-art in multiscale computer modeling, in terms of both accomplishments and challenges. The information in the book is particularly useful for biomedical engineers, medical physicists and researchers in systems biology, mathematical biology, micro-biomechanics and biomaterials who are interested in how to bridge between traditional biomedical engineering work at the organ and tissue scales, and the newer arenas of cellular and molecular bioengineering.

  11. The computer simulation of 3d gas dynamics in a gas centrifuge

    Science.gov (United States)

    Borman, V. D.; Bogovalov, S. V.; Borisevich, V. D.; Tronin, I. V.; Tronin, V. N.

    2016-09-01

    We argue on the basis of the results of 2D analysis of the gas flow in gas centrifuges that a reliable calculation of the circulation of the gas and gas content in the gas centrifuge is possible only in frameworks of 3D numerical simulation of gas dynamics in the gas centrifuge (hereafter GC). The group from National research nuclear university, MEPhI, has created a computer code for 3D simulation of the gas flow in GC. The results of the computer simulations of the gas flows in GC are presented. A model Iguassu centrifuge is explored for the simulations. A nonaxisymmetric gas flow is produced due to interaction of the hypersonic rotating flow with the scoops for extraction of the product and waste flows from the GC. The scoops produce shock waves penetrating into a working camera of the GC and form spiral waves there.

  12. Gust Acoustics Computation with a Space-Time CE/SE Parallel 3D Solver

    Science.gov (United States)

    Wang, X. Y.; Himansu, A.; Chang, S. C.; Jorgenson, P. C. E.; Reddy, D. R. (Technical Monitor)

    2002-01-01

    The benchmark Problem 2 in Category 3 of the Third Computational Aero-Acoustics (CAA) Workshop is solved using the space-time conservation element and solution element (CE/SE) method. This problem concerns the unsteady response of an isolated finite-span swept flat-plate airfoil bounded by two parallel walls to an incident gust. The acoustic field generated by the interaction of the gust with the flat-plate airfoil is computed by solving the 3D (three-dimensional) Euler equations in the time domain using a parallel version of a 3D CE/SE solver. The effect of the gust orientation on the far-field directivity is studied. Numerical solutions are presented and compared with analytical solutions, showing a reasonable agreement.

  13. Sand transverse dune aerodynamics: 3D Coherent Flow Structures from a computational study

    CERN Document Server

    Bruno, Luca

    2015-01-01

    The engineering interest about dune fields is dictated by the their interaction with a number of human infrastructures in arid environments. The aerodynamic behaviour of sand dunes in atmospheric boundary layer belongs to the class of bluff bodies. Because of their simple geometry and their frequent occurrence in desert area, transverse sand dunes are usually adopted in literature as a benchmark to investigate dune aerodynamics by means of both computational or experimental approach, usually in nominally 2D setups. The writers suspect the flow in the wake is characterised by 3D features and affected by wind tunnel setup - e.g. blockage effect, duct side wall boundary layer, incoming velocity profile - when experimental studies are carried out. The present study aims at evaluating the 3D flow features of an idealised transverse dune under different setup conditions by means of computational simulations and to compare the obtained results with experimental measurements.

  14. Confocal 3D DNA Cytometry: Assessment of Required Coefficient of Variation by Computer Simulation

    Directory of Open Access Journals (Sweden)

    Lennert S. Ploeger

    2004-01-01

    Full Text Available Background: Confocal Laser Scanning Microscopy (CLSM provides the opportunity to perform 3D DNA content measurements on intact cells in thick histological sections. So far, sample size has been limited by the time consuming nature of the technology. Since the power of DNA histograms to resolve different stemlines depends on both the sample size and the coefficient of variation (CV of histogram peaks, interpretation of 3D CLSM DNA histograms might be hampered by both a small sample size and a large CV. The aim of this study was to analyze the required CV for 3D CLSM DNA histograms given a realistic sample size. Methods: By computer simulation, virtual histograms were composed for sample sizes of 20000, 10000, 5000, 1000, and 273 cells and CVs of 30, 25, 20, 15, 10 and 5%. By visual inspection, the histogram quality with respect to resolution of G0/1 and G2/M peaks of a diploid stemline was assessed. Results: As expected, the interpretability of DNA histograms deteriorated with decreasing sample sizes and higher CVs. For CVs of 15% and lower, a clearly bimodal peak pattern with well distinguishable G0/1 and G2/M peaks were still seen at a sample size of 273 cells, which is our current average sample size with 3D CLSM DNA cytometry. Conclusions: For unambiguous interpretation of DNA histograms obtained using 3D CLSM, a CV of at most 15% is tolerable at currently achievable sample sizes. To resolve smaller near diploid stemlines, a CV of 10% or better should be aimed at. With currently available 3D imaging technology, this CV is achievable.

  15. Integration of 3D anatomical data obtained by CT imaging and 3D optical scanning for computer aided implant surgery

    Directory of Open Access Journals (Sweden)

    Paoli Alessandro

    2011-02-01

    Full Text Available Abstract Background A precise placement of dental implants is a crucial step to optimize both prosthetic aspects and functional constraints. In this context, the use of virtual guiding systems has been recognized as a fundamental tool to control the ideal implant position. In particular, complex periodontal surgeries can be performed using preoperative planning based on CT data. The critical point of the procedure relies on the lack of accuracy in transferring CT planning information to surgical field through custom-made stereo-lithographic surgical guides. Methods In this work, a novel methodology is proposed for monitoring loss of accuracy in transferring CT dental information into periodontal surgical field. The methodology is based on integrating 3D data of anatomical (impression and cast and preoperative (radiographic template models, obtained by both CT and optical scanning processes. Results A clinical case, relative to a fully edentulous jaw patient, has been used as test case to assess the accuracy of the various steps concurring in manufacturing surgical guides. In particular, a surgical guide has been designed to place implants in the bone structure of the patient. The analysis of the results has allowed the clinician to monitor all the errors, which have been occurring step by step manufacturing the physical templates. Conclusions The use of an optical scanner, which has a higher resolution and accuracy than CT scanning, has demonstrated to be a valid support to control the precision of the various physical models adopted and to point out possible error sources. A case study regarding a fully edentulous patient has confirmed the feasibility of the proposed methodology.

  16. 3D animation of facial plastic surgery based on computer graphics

    Science.gov (United States)

    Zhang, Zonghua; Zhao, Yan

    2013-12-01

    More and more people, especial women, are getting desired to be more beautiful than ever. To some extent, it becomes true because the plastic surgery of face was capable in the early 20th and even earlier as doctors just dealing with war injures of face. However, the effect of post-operation is not always satisfying since no animation could be seen by the patients beforehand. In this paper, by combining plastic surgery of face and computer graphics, a novel method of simulated appearance of post-operation will be given to demonstrate the modified face from different viewpoints. The 3D human face data are obtained by using 3D fringe pattern imaging systems and CT imaging systems and then converted into STL (STereo Lithography) file format. STL file is made up of small 3D triangular primitives. The triangular mesh can be reconstructed by using hash function. Top triangular meshes in depth out of numbers of triangles must be picked up by ray-casting technique. Mesh deformation is based on the front triangular mesh in the process of simulation, which deforms interest area instead of control points. Experiments on face model show that the proposed 3D animation facial plastic surgery can effectively demonstrate the simulated appearance of post-operation.

  17. 3D fast adaptive correlation imaging for large-scale gravity data based on GPU computation

    Science.gov (United States)

    Chen, Z.; Meng, X.; Guo, L.; Liu, G.

    2011-12-01

    In recent years, large scale gravity data sets have been collected and employed to enhance gravity problem-solving abilities of tectonics studies in China. Aiming at the large scale data and the requirement of rapid interpretation, previous authors have carried out a lot of work, including the fast gradient module inversion and Euler deconvolution depth inversion ,3-D physical property inversion using stochastic subspaces and equivalent storage, fast inversion using wavelet transforms and a logarithmic barrier method. So it can be say that 3-D gravity inversion has been greatly improved in the last decade. Many authors added many different kinds of priori information and constraints to deal with nonuniqueness using models composed of a large number of contiguous cells of unknown property and obtained good results. However, due to long computation time, instability and other shortcomings, 3-D physical property inversion has not been widely applied to large-scale data yet. In order to achieve 3-D interpretation with high efficiency and precision for geological and ore bodies and obtain their subsurface distribution, there is an urgent need to find a fast and efficient inversion method for large scale gravity data. As an entirely new geophysical inversion method, 3D correlation has a rapid development thanks to the advantage of requiring no a priori information and demanding small amount of computer memory. This method was proposed to image the distribution of equivalent excess masses of anomalous geological bodies with high resolution both longitudinally and transversely. In order to tranform the equivalence excess masses into real density contrasts, we adopt the adaptive correlation imaging for gravity data. After each 3D correlation imaging, we change the equivalence into density contrasts according to the linear relationship, and then carry out forward gravity calculation for each rectangle cells. Next, we compare the forward gravity data with real data, and

  18. Computation of 3D steady Navier-Stokes flow with free-surface gravity waves

    OpenAIRE

    Lewis, M. R.; Koren, Barry; Raven, H.C.

    2003-01-01

    In this paper an iterative method for the computation of stationary gravity-wave solutions is investigated, using a novel formulation of the free-surface (FS) boundary-value problem. This method requires the solution of a sequence of stationary Reynolds-Averaged Navier-Stokes subproblems employing the so-called quasi free-surface condition. The numerical performance of this new approach is investigated for two test cases. The first test case involves the computation of the 3D gravity-wave pat...

  19. THERM3D -- A boundary element computer program for transient heat conduction problems

    Energy Technology Data Exchange (ETDEWEB)

    Ingber, M.S. [New Mexico Univ., Albuquerque, NM (United States). Dept. of Mechanical Engineering

    1994-02-01

    The computer code THERM3D implements the direct boundary element method (BEM) to solve transient heat conduction problems in arbitrary three-dimensional domains. This particular implementation of the BEM avoids performing time-consuming domain integrations by approximating a ``generalized forcing function`` in the interior of the domain with the use of radial basis functions. An approximate particular solution is then constructed, and the original problem is transformed into a sequence of Laplace problems. The code is capable of handling a large variety of boundary conditions including isothermal, specified flux, convection, radiation, and combined convection and radiation conditions. The computer code is benchmarked by comparisons with analytic and finite element results.

  20. Multiscale approach for bone remodeling simulation based on finite element and neural network computation

    CERN Document Server

    Hambli, Ridha

    2011-01-01

    The aim of this paper is to develop a multiscale hierarchical hybrid model based on finite element analysis and neural network computation to link mesoscopic scale (trabecular network level) and macroscopic (whole bone level) to simulate bone remodelling process. Because whole bone simulation considering the 3D trabecular level is time consuming, the finite element calculation is performed at macroscopic level and a trained neural network are employed as numerical devices for substituting the finite element code needed for the mesoscale prediction. The bone mechanical properties are updated at macroscopic scale depending on the morphological organization at the mesoscopic computed by the trained neural network. The digital image-based modeling technique using m-CT and voxel finite element mesh is used to capture 2 mm3 Representative Volume Elements at mesoscale level in a femur head. The input data for the artificial neural network are a set of bone material parameters, boundary conditions and the applied str...

  1. Engineering Multi-scale Electrospun Structure for Integration into Architected 3-D Nanofibers for Cimex Annihilation: Fabrication and Mechanism Study

    Science.gov (United States)

    He, Shan; Zhang, Linxi; Liu, Ying; Rafailovich, Miriam; Garcia Center for Polymers at Engineered Interfaces Team

    In this study, engineered electrospun scaffolds with fibers oriented with designed curvature in three dimensions (3D) including the looped structure were developed based on the principle of electrostatic repulsion. Here we illustrate that 3D electrospun recycled polystyrene fibers could closely mimic the unique architectures of multi-direction and multi-layer nano-spiderweb. In contrast to virgin PS, the recycled PS (Dart Styrofoam) are known to contain zinc stearate which acts as a surfactant resulting in higher electrical charge and larger fiber curvature, hence, lower modulus. The surfactant, which is known to decrease the surface tension, may have also been effective at decreasing the confinement of the PS, where chain stretching was shown to occur, in response to the high surface tension at the air interface. Three dimensional flexible architecture with complex structures are shown to be necessary in order to block the motion of Cimex lectularius. Here we show how an engineered electrospun network of surfactant modified polymer fibers with calculated dimensions can be used to immobilize the insects. The mechanical response of the fibers has to be specifically tailored so that it is elastically deformed, without fracturing or flowing. Carefully controlling and tailoring the electrospinning parameters we can now utilize architected 3D nanofiber to create an environmental-friendly Cimex immobilization device which can lead to annihilation solution for all the other harmful insects.

  2. Automatic procedure for realistic 3D finite element modelling of human brain for bioelectromagnetic computations

    Energy Technology Data Exchange (ETDEWEB)

    Aristovich, K Y; Khan, S H, E-mail: kirill.aristovich.1@city.ac.u [School of Engineering and Mathematical Sciences, City University London, Northampton Square, London EC1V 0HB (United Kingdom)

    2010-07-01

    Realistic computer modelling of biological objects requires building of very accurate and realistic computer models based on geometric and material data, type, and accuracy of numerical analyses. This paper presents some of the automatic tools and algorithms that were used to build accurate and realistic 3D finite element (FE) model of whole-brain. These models were used to solve the forward problem in magnetic field tomography (MFT) based on Magnetoencephalography (MEG). The forward problem involves modelling and computation of magnetic fields produced by human brain during cognitive processing. The geometric parameters of the model were obtained from accurate Magnetic Resonance Imaging (MRI) data and the material properties - from those obtained from Diffusion Tensor MRI (DTMRI). The 3D FE models of the brain built using this approach has been shown to be very accurate in terms of both geometric and material properties. The model is stored on the computer in Computer-Aided Parametrical Design (CAD) format. This allows the model to be used in a wide a range of methods of analysis, such as finite element method (FEM), Boundary Element Method (BEM), Monte-Carlo Simulations, etc. The generic model building approach presented here could be used for accurate and realistic modelling of human brain and many other biological objects.

  3. A hybrid method for the computation of quasi-3D seismograms.

    Science.gov (United States)

    Masson, Yder; Romanowicz, Barbara

    2013-04-01

    The development of powerful computer clusters and efficient numerical computation methods, such as the Spectral Element Method (SEM) made possible the computation of seismic wave propagation in a heterogeneous 3D earth. However, the cost of theses computations is still problematic for global scale tomography that requires hundreds of such simulations. Part of the ongoing research effort is dedicated to the development of faster modeling methods based on the spectral element method. Capdeville et al. (2002) proposed to couple SEM simulations with normal modes calculation (C-SEM). Nissen-Meyer et al. (2007) used 2D SEM simulations to compute 3D seismograms in a 1D earth model. Thanks to these developments, and for the first time, Lekic et al. (2011) developed a 3D global model of the upper mantle using SEM simulations. At the local and continental scale, adjoint tomography that is using a lot of SEM simulation can be implemented on current computers (Tape, Liu et al. 2009). Due to their smaller size, these models offer higher resolution. They provide us with images of the crust and the upper part of the mantle. In an attempt to teleport such local adjoint tomographic inversions into the deep earth, we are developing a hybrid method where SEM computation are limited to a region of interest within the earth. That region can have an arbitrary shape and size. Outside this region, the seismic wavefield is extrapolated to obtain synthetic data at the Earth's surface. A key feature of the method is the use of a time reversal mirror to inject the wavefield induced by distant seismic source into the region of interest (Robertsson and Chapman 2000). We compute synthetic seismograms as follow: Inside the region of interest, we are using regional spectral element software RegSEM to compute wave propagation in 3D. Outside this region, the wavefield is extrapolated to the surface by convolution with the Green's functions from the mirror to the seismic stations. For now, these

  4. A Computational Model for Suspended Large Rigid Bodies in 3D Unsteady Viscous Flows

    Science.gov (United States)

    Xiao, Feng

    1999-11-01

    A 3D numerical model for computing large rigid objects suspended in fluid flow has been developed. Rather than calculating the surface pressure upon the solid body, we evaluate the net force and torque based on a volume force formulation. The total effective force is obtained by summing up the forces at the Eulerian grids occupied by the rigid body. The effects of the moving bodies are coupled to the fluid flow by imposing the velocity field of the bodies to the fluid. A Poisson equation is used to compute the pressure over the whole domain. The objects are identified by color functions and calculated by the PPM scheme and a tangent function transformation which scales the transition region of the computed interface to a compact thickness. The model is then implemented on a parallel computer of distributed memory and validated with Stokes and low Reynolds number flows.

  5. COMPUTATION OF MINKOWSKI MEASURES ON 2D AND 3D BINARY IMAGES

    Directory of Open Access Journals (Sweden)

    David Legland

    2011-05-01

    Full Text Available Minkowski functionals encompass standard geometric parameters such as volume, area, length and the Euler-Poincaré characteristic. Software tools for computing approximations of Minkowski functionals on binary 2D or 3D images are now available based on mathematical methods due to Serra, Lang and Ohser. Minkowski functionals can not be used to describe spatial heterogeneity of structures. This description can be performed by using Minkowski measures, which are local versions of Minkowski functionals. In this paper, we discuss how to extend the computation of Minkowski functionals to the computation of Minkowski measures. Approximations of Minkowski measures are computed using fltering and look-up table transformations. The final result is represented as a grey-level image. Approximation errors are investigated based on numerical examples. Convergence and non convergence of the measure approximations are discussed. The measure of surface area is used to describe spatial heterogeneity of a synthetic structure, and of an image of tomato pericarp.

  6. Computational fluid dynamics simulations of blood flow regularized by 3D phase contrast MRI

    DEFF Research Database (Denmark)

    Rispoli, Vinicius C; Nielsen, Jon; Nayak, Krishna S;

    2015-01-01

    BACKGROUND: Phase contrast magnetic resonance imaging (PC-MRI) is used clinically for quantitative assessment of cardiovascular flow and function, as it is capable of providing directly-measured 3D velocity maps. Alternatively, vascular flow can be estimated from model-based computation fluid...... approach in regularizing 3D flow fields is evaluated. METHODS: The proposed algorithm incorporates both a Newtonian fluid physics model and a linear PC-MRI signal model. The model equations are solved numerically using a modified CFD algorithm. The numerical solution corresponds to the optimal solution of...... dynamics (CFD) calculations. CFD provides arbitrarily high resolution, but its accuracy hinges on model assumptions, while velocity fields measured with PC-MRI generally do not satisfy the equations of fluid dynamics, provide limited resolution, and suffer from partial volume effects. The purpose of this...

  7. Computer-assisted three-dimensional surgical planning: 3D virtual articulator: technical note.

    Science.gov (United States)

    Ghanai, S; Marmulla, R; Wiechnik, J; Mühling, J; Kotrikova, B

    2010-01-01

    This study presents a computer-assisted planning system for dysgnathia treatment. It describes the process of information gathering using a virtual articulator and how the splints are constructed for orthognathic surgery. The deviation of the virtually planned splints is shown in six cases on the basis of conventionally planned cases. In all cases the plaster models were prepared and scanned using a 3D laser scanner. Successive lateral and posterior-anterior cephalometric images were used for reconstruction before surgery. By identifying specific points on the X-rays and marking them on the virtual models, it was possible to enhance the 2D images to create a realistic 3D environment and to perform virtual repositioning of the jaw. A hexapod was used to transfer the virtual planning to the real splints. Preliminary results showed that conventional repositioning could be replicated using the virtual articulator.

  8. Computation of Edge-Edge-Edge Events Based on Conicoid Theory for 3-D Object Recognition

    Institute of Scientific and Technical Information of China (English)

    WU Chenye; MA Huimin

    2009-01-01

    The availability of a good viewpoint space partition is crucial in three dimensional (3-D) object rec-ognition on the approach of aspect graph. There are two important events depicted by the aspect graph ap-proach, edge-edge-edge (EEE) events and edge-vertex (EV) events. This paper presents an algorithm to compute EEE events by characteristic analysis based on conicoid theory, in contrast to current algorithms that focus too much on EV events and often overlook the importance of EEE events. Also, the paper provides a standard flowchart for the viewpoint space partitioning based on aspect graph theory that makes it suitable for perspective models. The partitioning result best demonstrates the algorithm's efficiency with more valu-able viewpoints found with the help of EEE events, which can definitely help to achieve high recognition rate for 3-D object recognition.

  9. Parallel Adaptive Computation of Blood Flow in a 3D ``Whole'' Body Model

    Science.gov (United States)

    Zhou, M.; Figueroa, C. A.; Taylor, C. A.; Sahni, O.; Jansen, K. E.

    2008-11-01

    Accurate numerical simulations of vascular trauma require the consideration of a larger portion of the vasculature than previously considered, due to the systemic nature of the human body's response. A patient-specific 3D model composed of 78 connected arterial branches extending from the neck to the lower legs is constructed to effectively represent the entire body. Recently developed outflow boundary conditions that appropriately represent the downstream vasculature bed which is not included in the 3D computational domain are applied at 78 outlets. In this work, the pulsatile blood flow simulations are started on a fairly uniform, unstructured mesh that is subsequently adapted using a solution-based approach to efficiently resolve the flow features. The adapted mesh contains non-uniform, anisotropic elements resulting in resolution that conforms with the physical length scales present in the problem. The effects of the mesh resolution on the flow field are studied, specifically on relevant quantities of pressure, velocity and wall shear stress.

  10. Computational 3D reconstructions by optimization for cryo-electron microscopy

    Science.gov (United States)

    Yin, Zhye; Zheng, Yili; Doerschuk, Peter C.; Johnson, John E.

    2003-06-01

    An algorithm for the simultaneous 3-D reconstruction of several types of object, where each type of object may possibly have a rotational symmetry, from 2-D projection images, where for each image the type of object imaged, the projection orientation used to create the image, and the location of the object in the image are unknown, is described. The motivating application is the determination of the 3-D structure of small spherical viruses from cryo electron microscopy images. The algorithm is a maximum likelihood estimator which is computed by expectation maximization (EM). Due to the structure of the statistical model, the maximization step of EM can be easily computed but the expectation step requires 5-D numerical quadrature. The computational burden of the quadratures necessitates parallel computation and three different implementations of two different types of parallelism have been developed using pthreads (for shared memory processors) and MPI (for distributed memory processors). An example applying one of the MPI implementations, running on a 32 node PC cluster, to experimental images of Flock House Virus with comparison to the x-ray crystal diffraction structure of the virus is described.

  11. A versatile pipeline for the multi-scale digital reconstruction and quantitative analysis of 3D tissue architecture

    Science.gov (United States)

    Morales-Navarrete, Hernán; Segovia-Miranda, Fabián; Klukowski, Piotr; Meyer, Kirstin; Nonaka, Hidenori; Marsico, Giovanni; Chernykh, Mikhail; Kalaidzidis, Alexander; Zerial, Marino; Kalaidzidis, Yannis

    2015-01-01

    A prerequisite for the systems biology analysis of tissues is an accurate digital three-dimensional reconstruction of tissue structure based on images of markers covering multiple scales. Here, we designed a flexible pipeline for the multi-scale reconstruction and quantitative morphological analysis of tissue architecture from microscopy images. Our pipeline includes newly developed algorithms that address specific challenges of thick dense tissue reconstruction. Our implementation allows for a flexible workflow, scalable to high-throughput analysis and applicable to various mammalian tissues. We applied it to the analysis of liver tissue and extracted quantitative parameters of sinusoids, bile canaliculi and cell shapes, recognizing different liver cell types with high accuracy. Using our platform, we uncovered an unexpected zonation pattern of hepatocytes with different size, nuclei and DNA content, thus revealing new features of liver tissue organization. The pipeline also proved effective to analyse lung and kidney tissue, demonstrating its generality and robustness. DOI: http://dx.doi.org/10.7554/eLife.11214.001 PMID:26673893

  12. Multi-Scale Modeling of the Basilica of San Pietro in Tuscania (Italy. From 3D Data to 2D Representation

    Directory of Open Access Journals (Sweden)

    Filiberto Chiabrando

    2011-12-01

    Full Text Available The Basilica of San Pietro is a Romanic architecture located in the municipality of Tuscania in the Lazio Region about 100 km far from Rome. In 1971 the apse dome collapsed during the earthquake and the important fresco of a Christ Pantocrator was destroyed. In 1975 the dome was reconstructed using reinforced concrete.In 2010 an integrated survey of the Church has been performed using LiDAR techniques integrated with photogrammetric and topographic methodologies in order to realize a complete 2D documentation of the Basilica of San Pietro. Thanks to the acquired data a complete multi-scale 3D model of the Church and of the surroundings was realized.The aim of this work is to present different strategies in order to realize correct documentations for Cultural Heritage knowledge, using typical 3D survey methodologies (i. e. LiDAR survey and photogrammetry.After data acquisition and processing, several 2D representations were realized in order to carry out traditional supports for the different actors involved in the conservation plans; moreover, starting from the 2D drawing a simplified 3D modeling methodology has been followed in order to define the fundamental geometry of the Basilica and the surroundings: the achieved model could be useful for a small architectural scale description of the structure and for the documentation of the surroundings. For the aforementioned small architectural scale model, the 3D modeling was realized using the information derived from the 2D drawings with an approach based on the Constructive Solid Geometry. Using this approach the real shape of the object is simplified. This methodology is employed in particular when the shape of the structures is simple or to communicate new project ideas of when, as in our case, the aim is to give an idea of the complexity of an architectural Cultural Heritage. In order to follow this objective, a small architectural scale model was realized: the area of the Civita hill was

  13. Multiscale computational modelling of the heart

    Science.gov (United States)

    Smith, N. P.; Nickerson, D. P.; Crampin, E. J.; Hunter, P. J.

    A computational framework is presented for integrating the electrical, mechanical and biochemical functions of the heart. Finite element techniques are used to solve the large-deformation soft tissue mechanics using orthotropic constitutive laws based in the measured fibre-sheet structure of myocardial (heart muscle) tissue. The reaction-diffusion equations governing electrical current flow in the heart are solved on a grid of deforming material points which access systems of ODEs representing the cellular processes underlying the cardiac action potential. Navier-Stokes equations are solved for coronary blood flow in a system of branching blood vessels embedded in the deforming myocardium and the delivery of oxygen and metabolites is coupled to the energy-dependent cellular processes. The framework presented here for modelling coupled physical conservation laws at the tissue and organ levels is also appropriate for other organ systems in the body and we briefly discuss applications to the lungs and the musculo-skeletal system. The computational framework is also designed to reach down to subcellular processes, including signal transduction cascades and metabolic pathways as well as ion channel electrophysiology, and we discuss the development of ontologies and markup language standards that will help link the tissue and organ level models to the vast array of gene and protein data that are now available in web-accessible databases.

  14. Multiscale modeling of lithium-ion battery electrodes based on nano-scale X-ray computed tomography

    Science.gov (United States)

    Kashkooli, Ali Ghorbani; Farhad, Siamak; Lee, Dong Un; Feng, Kun; Litster, Shawn; Babu, Siddharth Komini; Zhu, Likun; Chen, Zhongwei

    2016-03-01

    A multiscale platform has been developed to model lithium ion battery (LIB) electrodes based on the real microstructure morphology. This multiscale framework consists of a microscale level where the electrode microstructure architecture is modeled and a macroscale level where discharge/charge is simulated. The coupling between two scales are performed in real time unlike using common surrogate based models for microscale. For microscale geometry 3D microstructure is reconstructed based on the nano-scale X-ray computed tomography data replacing typical computer generated microstructure. It is shown that this model can predict the experimental performance of LiFePO4 (LFP) cathode at different discharge rates more accurate than the conventional homogenous models. The approach employed in this study provides valuable insight into the spatial distribution of lithium -ion inside the real microstructure of LIB electrodes. The inhomogenous microstructure of LFP causes a wider range of physical and electrochemical properties in microscale compared to homogenous models.

  15. Using 2D and 3D Computer Games to Detect Colorblindness – a Comparative Study

    Directory of Open Access Journals (Sweden)

    Laskowski Maciej

    2015-12-01

    Full Text Available Computer games have accompanied the development of computer technologies since the very beginning. Despite their basic, purely entertainment-targeted appliance, games can also be used for many other purposes. Medical applications are especially interesting, as games (especially different kinds of simulations are widely used for training personnel, e.g. to perform certain procedures or in learning to use equipment. This allows the trainees to gain knowledge and proper habits, as well as test themselves in different situations without any risk. Computer games can also be used as a diagnostic tool, although this topic is still insufficiently researched. This paper discusses the possibility of using serious games for diagnosing color vision disorders, focusing especially on two problems: differences in diagnosing colorblindness using 2D and 3D environments, and the influence of individual features, such as reflex or agility, on the diagnostic process.

  16. Computational Analysis of the Transonic Dynamics Tunnel Using FUN3D

    Science.gov (United States)

    Chwalowski, Pawel; Quon, Eliot; Brynildsen, Scott E.

    2016-01-01

    This paper presents results from an exploratory two-year effort of applying Computational Fluid Dynamics (CFD) to analyze the empty-tunnel flow in the NASA Langley Research Center Transonic Dynamics Tunnel (TDT). The TDT is a continuous-flow, closed circuit, 16- x 16-foot slotted-test-section wind tunnel, with capabilities to use air or heavy gas as a working fluid. In this study, experimental data acquired in the empty tunnel using the R-134a test medium was used to calibrate the computational data. The experimental calibration data includes wall pressures, boundary-layer profiles, and the tunnel centerline Mach number profiles. Subsonic and supersonic flow regimes were considered, focusing on Mach 0.5, 0.7 and Mach 1.1 in the TDT test section. This study discusses the computational domain, boundary conditions, and initial conditions selected and the resulting steady-state analyses using NASA's FUN3D CFD software.

  17. Coronary computed tomography angiography with 320-row detector and using the AIDR-3D: initial experience

    International Nuclear Information System (INIS)

    Coronary computed tomography angiography (coronary CTA) is a powerful non-invasive imaging method to evaluate coronary artery disease. Nowadays, coronary CTA estimated effective radiation dose can be dramatically reduced using state-of-the-art scanners, such as 320-row detector CT (320-CT), without changing coronary CTA diagnostic accuracy. To optimize and further reduce the radiation dose, new iterative reconstruction algorithms were released recently by several CT manufacturers, and now they are used routinely in coronary CTA. This paper presents our first experience using coronary CTA with 320-CT and the Adaptive Iterative Dose Reduction 3D (AIDR-3D). In addition, we describe the current indications for coronary CTA in our practice as well as the acquisition standard protocols and protocols related to CT application for radiation dose reduction. In conclusion, coronary CTA radiation dose can be dramatically reduced following the 'as low as reasonable achievable' principle by combination of exam indication and well-documented technics for radiation dose reduction, such as beta blockers, low-kV, and also the newest iterative dose reduction software as AIDR-3D. (author)

  18. 3D-CANVENT : an integrated computer package for simulating the underground mine ventilation systems

    Energy Technology Data Exchange (ETDEWEB)

    Li, G.; Kocsis, C.; Hardcastle, S. [Natural Resources Canada, Sudbury, ON (Canada). CANMET Mining and Mineral Sciences Laboratories

    2009-07-01

    Cool, fresh air is needed in the working areas of underground mines in order to remove pollutants created during mining operations and to create satisfactory air quality conditions. 3D-CANVENT is a computer package for simulating difficult underground ventilation systems that comprise airways, fans and control devices. The package has been recently upgraded and enhanced with several new features and capabilities. This paper discussed the advanced features and capabilities of 3D-CANVENT, as well as the improvements within its solver and the utilities that greatly enhanced data entry and processing. These features include fan libraries for archiving and retrieving fan data; auto-backup of ventilation models and simulation results; animation of airflow through ventilation networks; and integrated 3D processor for editing ventilation models and viewing simulation results in different windows and orientations. The paper also outlined and discussed the technology that incorporated the air density and natural ventilation pressure in ventilation analysis. A verification example was also provided. A new tool for sensitivity study on ventilation parameter changes was also proposed to further enhance the software. 7 refs., 7 figs.

  19. Generic camera model and its calibration for computational integral imaging and 3D reconstruction.

    Science.gov (United States)

    Li, Weiming; Li, Youfu

    2011-03-01

    Integral imaging (II) is an important 3D imaging technology. To reconstruct 3D information of the viewed objects, modeling and calibrating the optical pickup process of II are necessary. This work focuses on the modeling and calibration of an II system consisting of a lenslet array, an imaging lens, and a charge-coupled device camera. Most existing work on such systems assumes a pinhole array model (PAM). In this work, we explore a generic camera model that accommodates more generality. This model is an empirical model based on measurements, and we constructed a setup for its calibration. Experimental results show a significant difference between the generic camera model and the PAM. Images of planar patterns and 3D objects were computationally reconstructed with the generic camera model. Compared with the images reconstructed using the PAM, the images present higher fidelity and preserve more high spatial frequency components. To the best of our knowledge, this is the first attempt in applying a generic camera model to an II system.

  20. High-performance computational and geostatistical experiments for testing the capabilities of 3-d electrical tomography

    Energy Technology Data Exchange (ETDEWEB)

    Carle, S. F. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Daily, W. D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Newmark, R. L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Ramirez, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Tompson, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    1999-01-19

    This project explores the feasibility of combining geologic insight, geostatistics, and high-performance computing to analyze the capabilities of 3-D electrical resistance tomography (ERT). Geostatistical methods are used to characterize the spatial variability of geologic facies that control sub-surface variability of permeability and electrical resistivity Synthetic ERT data sets are generated from geostatistical realizations of alluvial facies architecture. The synthetic data sets enable comparison of the "truth" to inversion results, quantification of the ability to detect particular facies at particular locations, and sensitivity studies on inversion parameters

  1. Fatigue of hybrid glass/carbon composites: 3D computational studies

    DEFF Research Database (Denmark)

    Dai, Gaoming; Mishnaevsky, Leon

    2014-01-01

    3D computational simulations of fatigue of hybrid carbon/glass fiber reinforced composites is carried out using X-FEM and multifiber unit cell models. A new software code for the automatic generation of unit cell multifiber models of composites with randomly misaligned fibers of various properties...... cyclic loading effects) on fatigue behavior of the materials are carried out. It was demonstrated that the higher fraction of carbon fibers in hybrid composites is beneficial for the fatigue lifetime of the composites under tension-tension cyclic loading, but might have negative effect on the lifetime...

  2. The history of visual magic in computers how beautiful images are made in CAD, 3D, VR and AR

    CERN Document Server

    Peddie, Jon

    2013-01-01

    If you have ever looked at a fantastic adventure or science fiction movie, or an amazingly complex and rich computer game, or a TV commercial where cars or gas pumps or biscuits behaved liked people and wondered, ""How do they do that?"",  then you've experienced the magic of 3D worlds generated by a computer.3D in computers began as a way to represent automotive designs and illustrate the construction of molecules. 3D graphics use evolved to visualizations of simulated data and artistic representations of imaginary worlds. In order to overcome the processing limitations of the computer, graph

  3. Integrated Multiscale Modeling of Molecular Computing Devices

    Energy Technology Data Exchange (ETDEWEB)

    Jerzy Bernholc

    2011-02-03

    Nanoscience has been one of the major research focuses of the U.S. and much of the world for the past decade, in part because of its promise to revolutionize many fields, including materials, medicine, and electronics. At the heart of this promise is the fact that nanostructured materials can behave radically differently than their macroscopic counterparts (e.g., bulk gold is such an inert metal that it has found applications in such diverse fields as jewelry, biomedical implants and dentistry, whereas gold nanoparticles are highly reactive and are thus useful as nanocatalysts) and have properties that are tunable due to a strong dependence on the size and surface area of the nanostructure. Thus, nanoscience offers a remarkable opportunity to develop new functional systems built around nanostructured materials with unusual and tunable properties and functionality. The transition from nanoscience to nanotechnology becomes possible when nanostructured systems can be made reproducibly by processes that can be implemented on a large scale. The microelectronics industry is one example of an industry that has evolved into the realm of nanotechnology, since the exponential reduction in feature size in computer chips has resulted in feature sizes now under 50nm (45nm in production, 32nm demonstrated; feature size has been going down by a factor of approximately 1/{radical}2 every 18 months as chip density has doubled every 18 months according to Moore's law). Silicon-based microelectronics relies on etching features into a single-crystal silicon substrate by photolithography. As the feature size of silicon-based microelectronics continues to decrease, the continuation of Moore's law to below 20nm feature sizes is being questioned, due to limitations in both the physics of the transistors (leading to unacceptable power dissipation) and doubts about the scalability of top-down photolithography-based manufacturing to such small sizes. There is no doubt that

  4. Integrated Multiscale Modeling of Molecular Computing Devices

    Energy Technology Data Exchange (ETDEWEB)

    Gregory Beylkin

    2012-03-23

    Significant advances were made on all objectives of the research program. We have developed fast multiresolution methods for performing electronic structure calculations with emphasis on constructing efficient representations of functions and operators. We extended our approach to problems of scattering in solids, i.e. constructing fast algorithms for computing above the Fermi energy level. Part of the work was done in collaboration with Robert Harrison and George Fann at ORNL. Specific results (in part supported by this grant) are listed here and are described in greater detail. (1) We have implemented a fast algorithm to apply the Green's function for the free space (oscillatory) Helmholtz kernel. The algorithm maintains its speed and accuracy when the kernel is applied to functions with singularities. (2) We have developed a fast algorithm for applying periodic and quasi-periodic, oscillatory Green's functions and those with boundary conditions on simple domains. Importantly, the algorithm maintains its speed and accuracy when applied to functions with singularities. (3) We have developed a fast algorithm for obtaining and applying multiresolution representations of periodic and quasi-periodic Green's functions and Green's functions with boundary conditions on simple domains. (4) We have implemented modifications to improve the speed of adaptive multiresolution algorithms for applying operators which are represented via a Gaussian expansion. (5) We have constructed new nearly optimal quadratures for the sphere that are invariant under the icosahedral rotation group. (6) We obtained new results on approximation of functions by exponential sums and/or rational functions, one of the key methods that allows us to construct separated representations for Green's functions. (7) We developed a new fast and accurate reduction algorithm for obtaining optimal approximation of functions by exponential sums and/or their rational representations.

  5. Quick, Accurate, Smart: 3D Computer Vision Technology Helps Assessing Confined Animals’ Behaviour

    Science.gov (United States)

    Calderara, Simone; Pistocchi, Simone; Cucchiara, Rita; Podaliri-Vulpiani, Michele; Messori, Stefano; Ferri, Nicola

    2016-01-01

    Mankind directly controls the environment and lifestyles of several domestic species for purposes ranging from production and research to conservation and companionship. These environments and lifestyles may not offer these animals the best quality of life. Behaviour is a direct reflection of how the animal is coping with its environment. Behavioural indicators are thus among the preferred parameters to assess welfare. However, behavioural recording (usually from video) can be very time consuming and the accuracy and reliability of the output rely on the experience and background of the observers. The outburst of new video technology and computer image processing gives the basis for promising solutions. In this pilot study, we present a new prototype software able to automatically infer the behaviour of dogs housed in kennels from 3D visual data and through structured machine learning frameworks. Depth information acquired through 3D features, body part detection and training are the key elements that allow the machine to recognise postures, trajectories inside the kennel and patterns of movement that can be later labelled at convenience. The main innovation of the software is its ability to automatically cluster frequently observed temporal patterns of movement without any pre-set ethogram. Conversely, when common patterns are defined through training, a deviation from normal behaviour in time or between individuals could be assessed. The software accuracy in correctly detecting the dogs’ behaviour was checked through a validation process. An automatic behaviour recognition system, independent from human subjectivity, could add scientific knowledge on animals’ quality of life in confinement as well as saving time and resources. This 3D framework was designed to be invariant to the dog’s shape and size and could be extended to farm, laboratory and zoo quadrupeds in artificial housing. The computer vision technique applied to this software is innovative in non

  6. Quick, Accurate, Smart: 3D Computer Vision Technology Helps Assessing Confined Animals' Behaviour.

    Directory of Open Access Journals (Sweden)

    Shanis Barnard

    Full Text Available Mankind directly controls the environment and lifestyles of several domestic species for purposes ranging from production and research to conservation and companionship. These environments and lifestyles may not offer these animals the best quality of life. Behaviour is a direct reflection of how the animal is coping with its environment. Behavioural indicators are thus among the preferred parameters to assess welfare. However, behavioural recording (usually from video can be very time consuming and the accuracy and reliability of the output rely on the experience and background of the observers. The outburst of new video technology and computer image processing gives the basis for promising solutions. In this pilot study, we present a new prototype software able to automatically infer the behaviour of dogs housed in kennels from 3D visual data and through structured machine learning frameworks. Depth information acquired through 3D features, body part detection and training are the key elements that allow the machine to recognise postures, trajectories inside the kennel and patterns of movement that can be later labelled at convenience. The main innovation of the software is its ability to automatically cluster frequently observed temporal patterns of movement without any pre-set ethogram. Conversely, when common patterns are defined through training, a deviation from normal behaviour in time or between individuals could be assessed. The software accuracy in correctly detecting the dogs' behaviour was checked through a validation process. An automatic behaviour recognition system, independent from human subjectivity, could add scientific knowledge on animals' quality of life in confinement as well as saving time and resources. This 3D framework was designed to be invariant to the dog's shape and size and could be extended to farm, laboratory and zoo quadrupeds in artificial housing. The computer vision technique applied to this software is

  7. Quick, Accurate, Smart: 3D Computer Vision Technology Helps Assessing Confined Animals' Behaviour.

    Science.gov (United States)

    Barnard, Shanis; Calderara, Simone; Pistocchi, Simone; Cucchiara, Rita; Podaliri-Vulpiani, Michele; Messori, Stefano; Ferri, Nicola

    2016-01-01

    Mankind directly controls the environment and lifestyles of several domestic species for purposes ranging from production and research to conservation and companionship. These environments and lifestyles may not offer these animals the best quality of life. Behaviour is a direct reflection of how the animal is coping with its environment. Behavioural indicators are thus among the preferred parameters to assess welfare. However, behavioural recording (usually from video) can be very time consuming and the accuracy and reliability of the output rely on the experience and background of the observers. The outburst of new video technology and computer image processing gives the basis for promising solutions. In this pilot study, we present a new prototype software able to automatically infer the behaviour of dogs housed in kennels from 3D visual data and through structured machine learning frameworks. Depth information acquired through 3D features, body part detection and training are the key elements that allow the machine to recognise postures, trajectories inside the kennel and patterns of movement that can be later labelled at convenience. The main innovation of the software is its ability to automatically cluster frequently observed temporal patterns of movement without any pre-set ethogram. Conversely, when common patterns are defined through training, a deviation from normal behaviour in time or between individuals could be assessed. The software accuracy in correctly detecting the dogs' behaviour was checked through a validation process. An automatic behaviour recognition system, independent from human subjectivity, could add scientific knowledge on animals' quality of life in confinement as well as saving time and resources. This 3D framework was designed to be invariant to the dog's shape and size and could be extended to farm, laboratory and zoo quadrupeds in artificial housing. The computer vision technique applied to this software is innovative in non

  8. Computer-controlled dynamic mode multidirectional UV lithography for 3D microfabrication

    International Nuclear Information System (INIS)

    Computer-controlled dynamic mode multidirectional ultraviolet (UV) lithography has been demonstrated using a collimated UV light source, a substrate-holding stage equipped with two stepper motors (one for tilting and the other for rotation), a controller with programming software and a laptop computer. The tilting and rotational angles of the stage in motion are accurately controlled during UV exposure as programmed by the user to produce complex three-dimensional (3D) microstructures. Process parameters include the initial and final tilting and rotational angles of the stage, and the relative angular velocities of the two motors in addition to the normal fabrication process parameters of UV lithography such as optical dose, baking time, and developing time and condition. Symmetric patterns can be generated by a simple synchronous mode dynamic operation, where both the angular velocities of the tilting motion and the rotating motion are set equal or harmonically related. More complex and non-symmetric patterns can be obtained using a piecewise synchronous mode, where the relationship between the angular velocities of the two motors is described not with a single coefficient but with a set of coefficients. 3D structures fabricated from the synchronous mode operation include the four-leaf clover horn and the cardiac horn while the ones from the piecewise synchronous mode are a vertical triangular slab, a screwed wind vane and arbitrary shape horns. Ray trace simulation has been performed using a mathematical tool in a spherical coordinate system and the simulated 3D patterns show good agreement with the fabricated ones.

  9. 3D modeling method for computer animate based on modified weak structured light method

    Science.gov (United States)

    Xiong, Hanwei; Pan, Ming; Zhang, Xiangwei

    2010-11-01

    A simple and affordable 3D scanner is designed in this paper. Three-dimensional digital models are playing an increasingly important role in many fields, such as computer animate, industrial design, artistic design and heritage conservation. For many complex shapes, optical measurement systems are indispensable to acquiring the 3D information. In the field of computer animate, such an optical measurement device is too expensive to be widely adopted, and on the other hand, the precision is not as critical a factor in that situation. In this paper, a new cheap 3D measurement system is implemented based on modified weak structured light, using only a video camera, a light source and a straight stick rotating on a fixed axis. For an ordinary weak structured light configuration, one or two reference planes are required, and the shadows on these planes must be tracked in the scanning process, which destroy the convenience of this method. In the modified system, reference planes are unnecessary, and size range of the scanned objects is expanded widely. A new calibration procedure is also realized for the proposed method, and points cloud is obtained by analyzing the shadow strips on the object. A two-stage ICP algorithm is used to merge the points cloud from different viewpoints to get a full description of the object, and after a series of operations, a NURBS surface model is generated in the end. A complex toy bear is used to verify the efficiency of the method, and errors range from 0.7783mm to 1.4326mm comparing with the ground truth measurement.

  10. Multiscale Computation. Needs and Opportunities for BER Science

    Energy Technology Data Exchange (ETDEWEB)

    Scheibe, Timothy D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Smith, Jeremy C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-01-01

    The Environmental Molecular Sciences Laboratory (EMSL), a scientific user facility managed by Pacific Northwest National Laboratory for the U.S. Department of Energy, Office of Biological and Environmental Research (BER), conducted a one-day workshop on August 26, 2014 on the topic of “Multiscale Computation: Needs and Opportunities for BER Science.” Twenty invited participants, from various computational disciplines within the BER program research areas, were charged with the following objectives; Identify BER-relevant models and their potential cross-scale linkages that could be exploited to better connect molecular-scale research to BER research at larger scales and; Identify critical science directions that will motivate EMSL decisions regarding future computational (hardware and software) architectures.

  11. Compute extremely low-frequency electromagnetic field exposure by 3-D impendance method

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A 3-D impedance method has been introduced to compute the electric currents induced in a human body exposed to extremely low-frequency electromagnetic field.The 3-D impedance method has been deduced from Maxwell equations and is put into the computation and simulation effectively to the visible human body model, which has 196×114×626 cells and more than 40 types of tissues.As the result, two representative cases are investigated.One is exposure of the human body to 100 μT (1 000 mG), the limit recommended by the International Commission on Non-Ionizing Radiation Protection for the public and the other one is the exposure of human body to 0.4 μT (4 mG), the level at which a statistical link appears with a doubled risk of development of childhood leukaemia.The distribution of induced current density can be obtained and the maximum of induced current are found to be 16 mA/m2 and 0.07 mA/m2.

  12. Using Computer-Aided Design Software and 3D Printers to Improve Spatial Visualization

    Science.gov (United States)

    Katsio-Loudis, Petros; Jones, Millie

    2015-01-01

    Many articles have been published on the use of 3D printing technology. From prefabricated homes and outdoor structures to human organs, 3D printing technology has found a niche in many fields, but especially education. With the introduction of AutoCAD technical drawing programs and now 3D printing, learners can use 3D printed models to develop…

  13. Fast computation of scattering from 3D complex structures by MLFMA

    Institute of Scientific and Technical Information of China (English)

    Hu Jun; Nie Zaiping; Que Xiaofeng; Meng Min

    2008-01-01

    This paper introduces the research work on the extension of multilevel fast multipole algorithm (MLFMA) to 3D complex structures including coating object,thin dielectric sheet,composite dielectric and conductor,cavity.The impedance boundary condition is used for scattering from the object coated by thin lossy material.Instead of volume integral equation,surface integral equation is applied in case of thin dielectric sheet through resistive sheet boundary condition.To realize the fast computation of scattering from composite homogeneous dielectric and conductor,the surface integral equation based on equivalence principle is used.Compared with the traditional volume integral equation,the surface integral equation reduces greatly the number of unknowns.To compute conducting cavity with electrically large aperture,an electric field integral equation is applied.Some numerical results are given to demonstrate the validity and accuracy of the present methods.

  14. Computational Approach to 3D Modeling of the Lymph Node Geometry

    Directory of Open Access Journals (Sweden)

    Alexey Kislitsyn

    2015-05-01

    Full Text Available In this study we present a computational approach to the generation of the major geometric structures of an idealized murine lymph node (LN. In this generation, we consider the major compartments such as the subcapsular sinus, B cell follicles, trabecular and medullar sinuses, blood vessels and the T cell zone with a primary focus on the fibroblastic reticular cell (FRC network. Confocal microscopy data of LN macroscopic structures and structural properties of the FRC network have been generated and utilized in the present model. The methodology sets a library of modules that can be used to assemble a solid geometric LN model and subsequently generate an adaptive mesh model capable of implementing transport phenomena. Overall, based on the use of high-resolution confocal microscopy and morphological analysis of cell 3D reconstructions, we have developed a computational model of the LN geometry, suitable for further investigation in studies of fluid transport and cell migration in this immunologically essential organ.

  15. A review of automated image understanding within 3D baggage computed tomography security screening.

    Science.gov (United States)

    Mouton, Andre; Breckon, Toby P

    2015-01-01

    Baggage inspection is the principal safeguard against the transportation of prohibited and potentially dangerous materials at airport security checkpoints. Although traditionally performed by 2D X-ray based scanning, increasingly stringent security regulations have led to a growing demand for more advanced imaging technologies. The role of X-ray Computed Tomography is thus rapidly expanding beyond the traditional materials-based detection of explosives. The development of computer vision and image processing techniques for the automated understanding of 3D baggage-CT imagery is however, complicated by poor image resolutions, image clutter and high levels of noise and artefacts. We discuss the recent and most pertinent advancements and identify topics for future research within the challenging domain of automated image understanding for baggage security screening CT.

  16. Multiscale modeling and computation of optically manipulated nano devices

    Science.gov (United States)

    Bao, Gang; Liu, Di; Luo, Songting

    2016-07-01

    We present a multiscale modeling and computational scheme for optical-mechanical responses of nanostructures. The multi-physical nature of the problem is a result of the interaction between the electromagnetic (EM) field, the molecular motion, and the electronic excitation. To balance accuracy and complexity, we adopt the semi-classical approach that the EM field is described classically by the Maxwell equations, and the charged particles follow the Schrödinger equations quantum mechanically. To overcome the numerical challenge of solving the high dimensional multi-component many-body Schrödinger equations, we further simplify the model with the Ehrenfest molecular dynamics to determine the motion of the nuclei, and use the Time-Dependent Current Density Functional Theory (TD-CDFT) to calculate the excitation of the electrons. This leads to a system of coupled equations that computes the electromagnetic field, the nuclear positions, and the electronic current and charge densities simultaneously. In the regime of linear responses, the resonant frequencies initiating the out-of-equilibrium optical-mechanical responses can be formulated as an eigenvalue problem. A self-consistent multiscale method is designed to deal with the well separated space scales. The isomerization of azobenzene is presented as a numerical example.

  17. "Let's get physical": advantages of a physical model over 3D computer models and textbooks in learning imaging anatomy.

    Science.gov (United States)

    Preece, Daniel; Williams, Sarah B; Lam, Richard; Weller, Renate

    2013-01-01

    Three-dimensional (3D) information plays an important part in medical and veterinary education. Appreciating complex 3D spatial relationships requires a strong foundational understanding of anatomy and mental 3D visualization skills. Novel learning resources have been introduced to anatomy training to achieve this. Objective evaluation of their comparative efficacies remains scarce in the literature. This study developed and evaluated the use of a physical model in demonstrating the complex spatial relationships of the equine foot. It was hypothesized that the newly developed physical model would be more effective for students to learn magnetic resonance imaging (MRI) anatomy of the foot than textbooks or computer-based 3D models. Third year veterinary medicine students were randomly assigned to one of three teaching aid groups (physical model; textbooks; 3D computer model). The comparative efficacies of the three teaching aids were assessed through students' abilities to identify anatomical structures on MR images. Overall mean MRI assessment scores were significantly higher in students utilizing the physical model (86.39%) compared with students using textbooks (62.61%) and the 3D computer model (63.68%) (P computer model groups (P = 0.685). Student feedback was also more positive in the physical model group compared with both the textbook and 3D computer model groups. Our results suggest that physical models may hold a significant advantage over alternative learning resources in enhancing visuospatial and 3D understanding of complex anatomical architecture, and that 3D computer models have significant limitations with regards to 3D learning.

  18. Multiscale analysis and computation for flows in heterogeneous media

    Energy Technology Data Exchange (ETDEWEB)

    Efendiev, Yalchin [Texas A & M Univ., College Station, TX (United States); Hou, T. Y. [California Inst. of Technology (CalTech), Pasadena, CA (United States); Durlofsky, L. J. [Stanford Univ., CA (United States); Tchelepi, H. [Stanford Univ., CA (United States)

    2016-08-04

    Our work in this project is aimed at making fundamental advances in multiscale methods for flow and transport in highly heterogeneous porous media. The main thrust of this research is to develop a systematic multiscale analysis and efficient coarse-scale models that can capture global effects and extend existing multiscale approaches to problems with additional physics and uncertainties. A key emphasis is on problems without an apparent scale separation. Multiscale solution methods are currently under active investigation for the simulation of subsurface flow in heterogeneous formations. These procedures capture the effects of fine-scale permeability variations through the calculation of specialized coarse-scale basis functions. Most of the multiscale techniques presented to date employ localization approximations in the calculation of these basis functions. For some highly correlated (e.g., channelized) formations, however, global effects are important and these may need to be incorporated into the multiscale basis functions. Other challenging issues facing multiscale simulations are the extension of existing multiscale techniques to problems with additional physics, such as compressibility, capillary effects, etc. In our project, we explore the improvement of multiscale methods through the incorporation of additional (single-phase flow) information and the development of a general multiscale framework for flows in the presence of uncertainties, compressible flow and heterogeneous transport, and geomechanics. We have considered (1) adaptive local-global multiscale methods, (2) multiscale methods for the transport equation, (3) operator-based multiscale methods and solvers, (4) multiscale methods in the presence of uncertainties and applications, (5) multiscale finite element methods for high contrast porous media and their generalizations, and (6) multiscale methods for geomechanics. Below, we present a brief overview of each of these contributions.

  19. Soft computing approach to 3D lung nodule segmentation in CT.

    Science.gov (United States)

    Badura, P; Pietka, E

    2014-10-01

    This paper presents a novel, multilevel approach to the segmentation of various types of pulmonary nodules in computed tomography studies. It is based on two branches of computational intelligence: the fuzzy connectedness (FC) and the evolutionary computation. First, the image and auxiliary data are prepared for the 3D FC analysis during the first stage of an algorithm - the masks generation. Its main goal is to process some specific types of nodules connected to the pleura or vessels. It consists of some basic image processing operations as well as dedicated routines for the specific cases of nodules. The evolutionary computation is performed on the image and seed points in order to shorten the FC analysis and improve its accuracy. After the FC application, the remaining vessels are removed during the postprocessing stage. The method has been validated using the first dataset of studies acquired and described by the Lung Image Database Consortium (LIDC) and by its latest release - the LIDC-IDRI (Image Database Resource Initiative) database.

  20. Creating computer aided 3D model of spleen and kidney based based on Visible Human Project

    International Nuclear Information System (INIS)

    To investigate the efficacy of computer aided 3-dimensional (3D) reconstruction technique on visualization and modeling of gross anatomical structures with an affordable methodology applied on the spleen and kidney. From The Visible Human Project Dataset cryosection images, developed by the National Library of Medicine, the spleen and kidney sections were preferred to be used due to their highly distinct contours. The software used for the reconstruction were Surf Driver 3.5.3 for Mac and Cinema 4D X L version 7.1 for Mac OS X. This study was carried out in May 2004 at the Department of Anatomy, Hacettepe University, Ankara, Turkey. As a result of this study, it is determined that these 2 programs could be effectively used both for 3D modeling of the mentioned organs and volumetric analyses on these models. It is also seen that it is possible to hold the physical models of these gross anatomical digital ones with stereolithography technique by means of the data exchange file format provided by the program and present such images as anaglyph. Surf Driver 3.5.3 for Mac OS and Cinema 4 DXL version 7.1 for Mac OS X can be used effectively for reconstruction of gross anatomical structures from serial parallel sections with distinct contours such as spleen and kidney and the animation of models. These software constitute a highly effective way of getting volumetric calculations, spatial relations and morphometrical measurements of reconstructed structures. (author)

  1. A 3-D Computational Study of a Variable Camber Continuous Trailing Edge Flap (VCCTEF) Spanwise Segment

    Science.gov (United States)

    Kaul, Upender K.; Nguyen, Nhan T.

    2015-01-01

    Results of a computational study carried out to explore the effects of various elastomer configurations joining spanwise contiguous Variable Camber Continuous Trailing Edge Flap (VCCTEF) segments are reported here. This research is carried out as a proof-of-concept study that will seek to push the flight envelope in cruise with drag optimization as the objective. The cruise conditions can be well off design such as caused by environmental conditions, maneuvering, etc. To handle these off-design conditions, flap deflection is used so when the flap is deflected in a given direction, the aircraft angle of attack changes accordingly to maintain a given lift. The angle of attack is also a design parameter along with the flap deflection. In a previous 2D study,1 the effect of camber was investigated and the results revealed some insight into the relative merit of various camber settings of the VCCTEF. The present state of the art has not advanced sufficiently to do a full 3-D viscous analysis of the whole NASA Generic Transport Model (GTM) wing with VCCTEF deployed with elastomers. Therefore, this study seeks to explore the local effects of three contiguous flap segments on lift and drag of a model devised here to determine possible trades among various flap deflections to achieve desired lift and drag results. Although this approach is an approximation, it provides new insights into the "local" effects of the relative deflections of the contiguous spanwise flap systems and various elastomer segment configurations. The present study is a natural extension of the 2-D study to assess these local 3-D effects. Design cruise condition at 36,000 feet at free stream Mach number of 0.797 and a mean aerodynamic chord (MAC) based Reynolds number of 30.734x10(exp 6) is simulated for an angle of attack (AoA) range of 0 to 6 deg. In the previous 2-D study, the calculations revealed that the parabolic arc camber (1x2x3) and circular arc camber (VCCTEF222) offered the best L

  2. An improved version of NCOREL: A computer program for 3-D nonlinear supersonic potential flow computations

    Science.gov (United States)

    Siclari, Michael J.

    1988-01-01

    A computer code called NCOREL (for Nonconical Relaxation) has been developed to solve for supersonic full potential flows over complex geometries. The method first solves for the conical at the apex and then marches downstream in a spherical coordinate system. Implicit relaxation techniques are used to numerically solve the full potential equation at each subsequent crossflow plane. Many improvements have been made to the original code including more reliable numerics for computing wing-body flows with multiple embedded shocks, inlet flow through simulation, wake model and entropy corrections. Line relaxation or approximate factorization schemes are optionally available. Improved internal grid generation using analytic conformal mappings, supported by a simple geometric Harris wave drag input that was originally developed for panel methods and internal geometry package are some of the new features.

  3. Computer-aided detection of clustered microcalcifications in digital breast tomosynthesis: A 3D approach

    Science.gov (United States)

    Sahiner, Berkman; Chan, Heang-Ping; Hadjiiski, Lubomir M.; Helvie, Mark A.; Wei, Jun; Zhou, Chuan; Lu, Yao

    2012-01-01

    Purpose: To design a computer-aided detection (CADe) system for clustered microcalcifications in reconstructed digital breast tomosynthesis (DBT) volumes and to perform a preliminary evaluation of the CADe system. Methods: IRB approval and informed consent were obtained in this study. A data set of two-view DBT of 72 breasts containing microcalcification clusters was collected from 72 subjects who were scheduled to undergo breast biopsy. Based on tissue sampling results, 17 cases had breast cancer and 55 were benign. A separate data set of two-view DBT of 38 breasts free of clustered microcalcifications from 38 subjects was collected to independently estimate the number of false-positives (FPs) generated by the CADe system. A radiologist experienced in breast imaging marked the biopsied cluster of microcalcifications with a 3D bounding box using all available clinical and imaging information. A CADe system was designed to detect microcalcification clusters in the reconstructed volume. The system consisted of prescreening, clustering, and false-positive reduction stages. In the prescreening stage, the conspicuity of microcalcification-like objects was increased by an enhancement-modulated 3D calcification response function. An iterative thresholding and 3D object growing method was used to detect cluster seed objects, which were used as potential centers of microcalcification clusters. In the cluster detection stage, microcalcification candidates were identified using a second iterative thresholding procedure, which was applied to the signal-to-noise ratio (SNR) enhanced image voxels with a positive calcification response. Starting with each cluster seed object as the initial cluster center, a dynamic clustering algorithm formed a cluster candidate by including microcalcification candidates within a 3D neighborhood of the cluster seed object that satisfied the clustering criteria. The number, size, and SNR of the microcalcifications in a cluster candidate and the

  4. The NCOREL computer program for 3D nonlinear supersonic potential flow computations

    Science.gov (United States)

    Siclari, M. J.

    1983-01-01

    An innovative computational technique (NCOREL) was established for the treatment of three dimensional supersonic flows. The method is nonlinear in that it solves the nonconservative finite difference analog of the full potential equation and can predict the formation of supercritical cross flow regions, embedded and bow shocks. The method implicitly computes a conical flow at the apex (R = 0) of a spherical coordinate system and uses a fully implicit marching technique to obtain three dimensional cross flow solutions. This implies that the radial Mach number must remain supersonic. The cross flow solutions are obtained by using type dependent transonic relaxation techniques with the type dependency linked to the character of the cross flow velocity (i.e., subsonic/supersonic). The spherical coordinate system and marching on spherical surfaces is ideally suited to the computation of wing flows at low supersonic Mach numbers due to the elimination of the subsonic axial Mach number problems that exist in other marching codes that utilize Cartesian transverse marching planes.

  5. 3-D reconstruction of an ancient Egyptian mummy using X-ray computer tomography.

    Science.gov (United States)

    Baldock, C; Hughes, S W; Whittaker, D K; Taylor, J; Davis, R; Spencer, A J; Tonge, K; Sofat, A

    1994-12-01

    Computer tomography has been used to image and reconstruct in 3-D an Egyptian mummy from the collection of the British Museum. This study of Tjentmutengebtiu, a priestess from the 22nd dynasty (945-715 BC) revealed invaluable information of a scientific, Egyptological and palaeopathological nature without mutilation and destruction of the painted cartonnage case or linen wrappings. Precise details on the removal of the brain through the nasal cavity and the viscera from the abdominal cavity were obtained. The nature and composition of the false eyes were investigated. The detailed analysis of the teeth provided a much closer approximation of age at death. The identification of materials used for the various amulets including that of the figures placed in the viscera was graphically demonstrated using this technique.

  6. 3D FEA Computation of the CLIC Machine Detector Interface Magnets

    CERN Document Server

    Bartalesi, A

    2012-01-01

    A critical aspect of the Compact Linear Collider (CLIC) design is represented by the Accelerator/Experiment interface (called Machine Detector Interface or MDI). In the 3 TeV CLIC layout, the final focus QD0 quadrupole will be located inside the end-cap of the detector itself. This complex MDI scenario required to be simulated with a full 3D-FE analysis. This study was critical to check and control the magnetic cross-talk between the detector solenoid and the final focus magnet and therefore to optimize the design of an “antisolenoids” system needed to shield the QD0 and the e-/e+ beams from the detector magnetic field. In this paper the development and evolution of the computational FE model is presented together with the results obtained and their implication on the CLIC MDI design.

  7. Computational ghost imaging versus imaging laser radar for 3D imaging

    CERN Document Server

    Hardy, Nicholas D

    2012-01-01

    Ghost imaging has been receiving increasing interest for possible use as a remote-sensing system. There has been little comparison, however, between ghost imaging and the imaging laser radars with which it would be competing. Toward that end, this paper presents a performance comparison between a pulsed, computational ghost imager and a pulsed, floodlight-illumination imaging laser radar. Both are considered for range-resolving (3D) imaging of a collection of rough-surfaced objects at standoff ranges in the presence of atmospheric turbulence. Their spatial resolutions and signal-to-noise ratios are evaluated as functions of the system parameters, and these results are used to assess each system's performance trade-offs. Scenarios in which a reflective ghost-imaging system has advantages over a laser radar are identified.

  8. A 3D computer-aided design system applied to diagnosis and treatment planning in orthodontics and orthognathic surgery.

    Science.gov (United States)

    Motohashi, N; Kuroda, T

    1999-06-01

    The purpose of this article is to describe a newly developed 3D computer-aided design (CAD) system for the diagnostic set-up of casts in orthodontic diagnosis and treatment planning, and its preliminary clinical applications. The system comprises a measuring unit which obtains 3D information from the dental model using laser scanning, and a personal computer to generate the 3D graphics. When measuring the 3D shape of the model, to minimize blind sectors, the model is scanned from two different directions with the slit-ray laser beam by rotating the mounting angle of the model on the measuring device. For computed simulation of tooth movement, the representative planes, defined by the anatomical reference points, are formed for each individual tooth and are arranged along a guideline descriptive of the individual arch form. Subsequently, the 3D shape is imparted to each of the teeth arranged on the representative plane to form an arrangement of the 3D profile. When necessary, orthognathic surgery can be simulated by moving the mandibular dental arch three-dimensionally to establish the optimum occlusal relationship. Compared with hand-made set-up models, the computed diagnostic cast has advantages such as high-speed processing and quantitative evaluation on the amount of 3D movement of the individual tooth relative to the craniofacial plane. Trial clinical applications demonstrated that the use of this system facilitated the otherwise complicated and time-consuming mock surgery for treatment planning in orthognathic surgery.

  9. Analysis of bite marks in foodstuffs by computer tomography (cone beam CT)--3D reconstruction.

    Science.gov (United States)

    Marques, Jeidson; Musse, Jamilly; Caetano, Catarina; Corte-Real, Francisco; Corte-Real, Ana Teresa

    2013-12-01

    The use of three-dimensional (3D) analysis of forensic evidence is highlighted in comparison with traditional methods. This three-dimensional analysis is based on the registration of the surface from a bitten object. The authors propose to use Cone Beam Computed Tomography (CBCT), which is used in dental practice, in order to study the surface and interior of bitten objects and dental casts of suspects. In this study, CBCT is applied to the analysis of bite marks in foodstuffs, which may be found in a forensic case scenario. 6 different types of foodstuffs were used: chocolate, cheese, apple, chewing gum, pizza and tart (flaky pastry and custard). The food was bitten into and dental casts of the possible suspects were made. The dental casts and bitten objects were registered using an x-ray source and the CBCT equipment iCAT® (Pennsylvania, EUA). The software InVivo5® (Anatomage Inc, EUA) was used to visualize and analyze the tomographic slices and 3D reconstructions of the objects. For each material an estimate of its density was assessed by two methods: HU values and specific gravity. All the used materials were successfully reconstructed as good quality 3D images. The relative densities of the materials in study were compared. Amongst the foodstuffs, the chocolate had the highest density (median value 100.5 HU and 1,36 g/cm(3)), while the pizza showed to have the lowest (median value -775 HU and 0,39 g/cm(3)), on both scales. Through tomographic slices and three-dimensional reconstructions it was possible to perform the metric analysis of the bite marks in all the foodstuffs, except for the pizza. These measurements could also be obtained from the dental casts. The depth of the bite mark was also successfully determined in all the foodstuffs except for the pizza. Cone Beam Computed Tomography has the potential to become an important tool for forensic sciences, namely for the registration and analysis of bite marks in foodstuffs that may be found in a crime

  10. Enabling 3D-Liver Perfusion Mapping from MR-DCE Imaging Using Distributed Computing

    Directory of Open Access Journals (Sweden)

    Benjamin Leporq

    2013-01-01

    Full Text Available An MR acquisition protocol and a processing method using distributed computing on the European Grid Infrastructure (EGI to allow 3D liver perfusion parametric mapping after Magnetic Resonance Dynamic Contrast Enhanced (MR-DCE imaging are presented. Seven patients (one healthy control and six with chronic liver diseases were prospectively enrolled after liver biopsy. MR-dynamic acquisition was continuously performed in free-breathing during two minutes after simultaneous intravascular contrast agent (MS-325 blood pool agent injection. Hepatic capillary system was modeled by a 3-parameters one-compartment pharmacokinetic model. The processing step was parallelized and executed on the EGI. It was modeled and implemented as a grid workflow using the Gwendia language and the MOTEUR workflow engine. Results showed good reproducibility in repeated processing on the grid. The results obtained from the grid were well correlated with ROI-based reference method ran locally on a personal computer. The speed-up range was 71 to 242 with an average value of 126. In conclusion, distributed computing applied to perfusion mapping brings significant speed-up to quantification step to be used for further clinical studies in a research context. Accuracy would be improved with higher image SNR accessible on the latest 3T MR systems available today.

  11. FURN3D: A computer code for radiative heat transfer in pulverized coal furnaces

    Energy Technology Data Exchange (ETDEWEB)

    Ahluwalia, R.K.; Im, K.H.

    1992-08-01

    A computer code FURN3D has been developed for assessing the impact of burning different coals on heat absorption pattern in pulverized coal furnaces. The code is unique in its ability to conduct detailed spectral calculations of radiation transport in furnaces fully accounting for the size distributions of char, soot and ash particles, ash content, and ash composition. The code uses a hybrid technique of solving the three-dimensional radiation transport equation for absorbing, emitting and anisotropically scattering media. The technique achieves an optimal mix of computational speed and accuracy by combining the discrete ordinate method (S{sub 4}), modified differential approximation (MDA) and P, approximation in different range of optical thicknesses. The code uses spectroscopic data for estimating the absorption coefficients of participating gases C0{sub 2}, H{sub 2}0 and CO. It invokes Mie theory for determining the extinction and scattering coefficients of combustion particulates. The optical constants of char, soot and ash are obtained from dispersion relations derived from reflectivity, transmissivity and extinction measurements. A control-volume formulation is adopted for determining the temperature field inside the furnace. A simple char burnout model is employed for estimating heat release and evolution of particle size distribution. The code is written in Fortran 77, has modular form, and is machine-independent. The computer memory required by the code depends upon the number of grid points specified and whether the transport calculations are performed on spectral or gray basis.

  12. FURN3D: A computer code for radiative heat transfer in pulverized coal furnaces

    Energy Technology Data Exchange (ETDEWEB)

    Ahluwalia, R.K.; Im, K.H.

    1992-08-01

    A computer code FURN3D has been developed for assessing the impact of burning different coals on heat absorption pattern in pulverized coal furnaces. The code is unique in its ability to conduct detailed spectral calculations of radiation transport in furnaces fully accounting for the size distributions of char, soot and ash particles, ash content, and ash composition. The code uses a hybrid technique of solving the three-dimensional radiation transport equation for absorbing, emitting and anisotropically scattering media. The technique achieves an optimal mix of computational speed and accuracy by combining the discrete ordinate method (S[sub 4]), modified differential approximation (MDA) and P, approximation in different range of optical thicknesses. The code uses spectroscopic data for estimating the absorption coefficients of participating gases C0[sub 2], H[sub 2]0 and CO. It invokes Mie theory for determining the extinction and scattering coefficients of combustion particulates. The optical constants of char, soot and ash are obtained from dispersion relations derived from reflectivity, transmissivity and extinction measurements. A control-volume formulation is adopted for determining the temperature field inside the furnace. A simple char burnout model is employed for estimating heat release and evolution of particle size distribution. The code is written in Fortran 77, has modular form, and is machine-independent. The computer memory required by the code depends upon the number of grid points specified and whether the transport calculations are performed on spectral or gray basis.

  13. 3D Animation Essentials

    CERN Document Server

    Beane, Andy

    2012-01-01

    The essential fundamentals of 3D animation for aspiring 3D artists 3D is everywhere--video games, movie and television special effects, mobile devices, etc. Many aspiring artists and animators have grown up with 3D and computers, and naturally gravitate to this field as their area of interest. Bringing a blend of studio and classroom experience to offer you thorough coverage of the 3D animation industry, this must-have book shows you what it takes to create compelling and realistic 3D imagery. Serves as the first step to understanding the language of 3D and computer graphics (CG)Covers 3D anim

  14. A Fast Full Tensor Gravity computation algorithm for High Resolution 3D Geologic Interpretations

    Science.gov (United States)

    Jayaram, V.; Crain, K.; Keller, G. R.

    2011-12-01

    We present an algorithm to rapidly calculate the vertical gravity and full tensor gravity (FTG) values due to a 3-D geologic model. This algorithm can be implemented on single, multi-core CPU and graphical processing units (GPU) architectures. Our technique is based on the line element approximation with a constant density within each grid cell. This type of parameterization is well suited for high-resolution elevation datasets with grid size typically in the range of 1m to 30m. The large high-resolution data grids in our studies employ a pre-filtered mipmap pyramid type representation for the grid data known as the Geometry clipmap. The clipmap was first introduced by Microsoft Research in 2004 to do fly-through terrain visualization. This method caches nested rectangular extents of down-sampled data layers in the pyramid to create view-dependent calculation scheme. Together with the simple grid structure, this allows the gravity to be computed conveniently on-the-fly, or stored in a highly compressed format. Neither of these capabilities has previously been available. Our approach can perform rapid calculations on large topographies including crustal-scale models derived from complex geologic interpretations. For example, we used a 1KM Sphere model consisting of 105000 cells at 10m resolution with 100000 gravity stations. The line element approach took less than 90 seconds to compute the FTG and vertical gravity on an Intel Core i7 CPU at 3.07 GHz utilizing just its single core. Also, unlike traditional gravity computational algorithms, the line-element approach can calculate gravity effects at locations interior or exterior to the model. The only condition that must be met is the observation point cannot be located directly above the line element. Therefore, we perform a location test and then apply appropriate formulation to those data points. We will present and compare the computational performance of the traditional prism method versus the line element

  15. Computer-Aided Multiscale Modelling for Chemical Process Engineering

    DEFF Research Database (Denmark)

    Morales Rodriguez, Ricardo; Gani, Rafiqul

    2007-01-01

    Chemical processes are generally modeled through monoscale approaches, which, while not adequate, satisfy a useful role in product-process design. In this case, use of a multi-dimensional and multi-scale model-based approach has importance in product-process development. A computer-aided framework......T) for model translation, analysis and solution. The integration of ModDev, MoT and ICAS or any other external software or process simulator (using COM-Objects) permits the generation of different models and/or process configurations for purposes of simulation, design and analysis. Consequently, it is possible...... for model generation, analysis, solution and implementation is necessary for the development and application of the desired model-based approach for product-centric process design/analysis. This goal is achieved through the combination of a system for model development (ModDev), and a modelling tool (Mo...

  16. Simulation of a simple RCCS experiment with RELAP5-3D system code and computational fluid dynamics computer program

    International Nuclear Information System (INIS)

    A small scale experimental facility was designed to study the thermal hydraulic phenomena in the Reactor Cavity Cooling System (RCCS). The facility was scaled down from the full scale RCCS system by applying scaling laws. A set of RELAP5-3D simulations were performed to confirm the scaling calculations, and to refine and optimize the facility's configuration, instrumentation selection, and layout. Computational Fluid Dynamics (CFD) calculations using StarCCM+ were performed in order to study the flow patterns and two-phase water behavior in selected locations of the facility where expected complex flow structure occurs. (author)

  17. Application of computer-aided multi-scale modelling framework - Aerosol case study

    DEFF Research Database (Denmark)

    Heitzig, Martina; Gregson, Christopher; Sin, Gürkan;

    2011-01-01

    A computer-aided modelling tool for efficient multi-scale modelling has been developed and is applied to solve a multi-scale modelling problem related to design and evaluation of fragrance aerosol products. The developed modelling scenario spans three length scales and describes how droplets...

  18. 3-D Computational Modelling of Oblique Continental Collision near South Island, New Zealand

    Science.gov (United States)

    Karatun, L.; Pysklywec, R. N.

    2015-12-01

    The research explores the highly oblique continental convergence at the South Island of New Zealand, considering the fundamental geodynamic mechanisms of sub-crustal lithospheric deformation during the orogenesis. In addition to the high velocity of along-strike plate motion, the oppositely verging subduction zones bounding the collision make the problem inherently three-dimensional. To study such factors during orogenesis, we conduct 3D computational modelling and present the results of a series of new experiments configured for the oblique South Island collision. The geodynamic modelling uses ASPECT - a robust highly-scalable and extendable geodynamic code featuring adaptive mesh refinement and complex rheologies. The model domain is defined by a box with prescribed velocities on the left and right faces with varied ratio of convergent versus strike-slip components, periodic boundary conditions for the front and back faces, free surface on top, and free slip at the bottom. Two different rheology types are used: brittle (pressure-, strain rate-, and material strength-dependent) for crust and visco-plastic (temperature-, pressure- and strain rate-dependent) for mantle. The obtained results provide insight into the behaviour of the lithosphere under the situation of young oblique convergence. We focus on the development of the mantle lithosphere, considering how the morphology of the sub-crustal orogenic root evolves during the convergent/strike-slip plate motions. The numerical experiments explore the dependence of this process on such factors as ratio of convergent versus strike-slip motion at the plate boundary, and rheological parameters of crust and mantle. The behaviour of the crust is also tracked to determine how the deep 3D tectonics may manifest at the surface.

  19. Multislice computed tomography angiography in the diagnosis of cardiovascular disease: 3D visualizations

    Institute of Scientific and Technical Information of China (English)

    Zhonghua Sun

    2011-01-01

    Multislice computed tomography (CT) has been widely used in clinical practice for the diagnosis of cardiovascular disease due to its reduced invasiveness and high spatial and temporal resolution.As a reliable alternative to conventional angiography,multislice CT angiography has been recognized as the method of choice for detecting and diagnosing head and neck vascular disease,abdominal aortic aneurysm,aortic dissection,and pulmonary embolism.In patients with suspected coronary artery disease,although invasive coronary angiography still remains as the gold standard technique,multislice CT angiography demonstrates high diagnostic accuracy; in selected patients,it is considered as the first-line technique.The imaging diagnosis of cardiovascular disease is based on a combination of two-dimensional (2D) and three-dimensional (3D) visualization tools to enhance the diagnostic value.This is facilitated by reconstructed visualizations which provide additional information about the extent of the disease,an accurate assessment of the spatial relationship between normal structures and pathological changes,and pre-operative planning and post-procedure follow-up.The aim of the present article is to present an overview of the diagnostic performance of various 2D and 3D CT visualizations in cardiovascular disease,including multiplanar reformation,maximum intensity projection,volume rendering,and virtual intravascular endoscopy.The recognition of the potential value of these visualizations will assist clinicians in efficiently using the muitislice CT imaging modality for the diagnostic management of patients with cardiovascular disease.

  20. Potential hazards of viewing 3-D stereoscopic television, cinema and computer games: a review.

    Science.gov (United States)

    Howarth, Peter A

    2011-03-01

    The visual stimulus provided by a 3-D stereoscopic display differs from that of the real world because the image provided to each eye is produced on a flat surface. The distance from the screen to the eye remains fixed, providing a single focal distance, but the introduction of disparity between the images allows objects to be located geometrically in front of, or behind, the screen. Unlike in the real world, the stimulus to accommodation and the stimulus to convergence do not match. Although this mismatch is used positively in some forms of Orthoptic treatment, a number of authors have suggested that it could negatively lead to the development of asthenopic symptoms. From knowledge of the zone of clear, comfortable, single binocular vision one can predict that, for people with normal binocular vision, adverse symptoms will not be present if the discrepancy is small, but are likely if it is large, and that what constitutes 'large' and 'small' are idiosyncratic to the individual. The accommodation-convergence mismatch is not, however, the only difference between the natural and the artificial stimuli. In the former case, an object located in front of, or behind, a fixated object will not only be perceived as double if the images fall outside Panum's fusional areas, but it will also be defocused and blurred. In the latter case, however, it is usual for the producers of cinema, TV or computer game content to provide an image that is in focus over the whole of the display, and as a consequence diplopic images will be sharply in focus. The size of Panum's fusional area is spatial frequency-dependent, and because of this the high spatial frequencies present in the diplopic 3-D image will provide a different stimulus to the fusion system from that found naturally. PMID:21309798

  1. Potential hazards of viewing 3-D stereoscopic television, cinema and computer games: a review.

    Science.gov (United States)

    Howarth, Peter A

    2011-03-01

    The visual stimulus provided by a 3-D stereoscopic display differs from that of the real world because the image provided to each eye is produced on a flat surface. The distance from the screen to the eye remains fixed, providing a single focal distance, but the introduction of disparity between the images allows objects to be located geometrically in front of, or behind, the screen. Unlike in the real world, the stimulus to accommodation and the stimulus to convergence do not match. Although this mismatch is used positively in some forms of Orthoptic treatment, a number of authors have suggested that it could negatively lead to the development of asthenopic symptoms. From knowledge of the zone of clear, comfortable, single binocular vision one can predict that, for people with normal binocular vision, adverse symptoms will not be present if the discrepancy is small, but are likely if it is large, and that what constitutes 'large' and 'small' are idiosyncratic to the individual. The accommodation-convergence mismatch is not, however, the only difference between the natural and the artificial stimuli. In the former case, an object located in front of, or behind, a fixated object will not only be perceived as double if the images fall outside Panum's fusional areas, but it will also be defocused and blurred. In the latter case, however, it is usual for the producers of cinema, TV or computer game content to provide an image that is in focus over the whole of the display, and as a consequence diplopic images will be sharply in focus. The size of Panum's fusional area is spatial frequency-dependent, and because of this the high spatial frequencies present in the diplopic 3-D image will provide a different stimulus to the fusion system from that found naturally.

  2. Parallel computing simulation of electrical excitation and conduction in the 3D human heart.

    Science.gov (United States)

    Di Yu; Dongping Du; Hui Yang; Yicheng Tu

    2014-01-01

    A correctly beating heart is important to ensure adequate circulation of blood throughout the body. Normal heart rhythm is produced by the orchestrated conduction of electrical signals throughout the heart. Cardiac electrical activity is the resulted function of a series of complex biochemical-mechanical reactions, which involves transportation and bio-distribution of ionic flows through a variety of biological ion channels. Cardiac arrhythmias are caused by the direct alteration of ion channel activity that results in changes in the AP waveform. In this work, we developed a whole-heart simulation model with the use of massive parallel computing with GPGPU and OpenGL. The simulation algorithm was implemented under several different versions for the purpose of comparisons, including one conventional CPU version and two GPU versions based on Nvidia CUDA platform. OpenGL was utilized for the visualization / interaction platform because it is open source, light weight and universally supported by various operating systems. The experimental results show that the GPU-based simulation outperforms the conventional CPU-based approach and significantly improves the speed of simulation. By adopting modern computer architecture, this present investigation enables real-time simulation and visualization of electrical excitation and conduction in the large and complicated 3D geometry of a real-world human heart.

  3. Computer-assisted diagnostic system for neurodegenerative dementia using brain SPECT and 3D-SSP

    Energy Technology Data Exchange (ETDEWEB)

    Ishii, Kazunari; Kanda, Tomonori; Uemura, Takafumi; Miyamoto, Naokazu; Yoshikawa, Toshiki [Hyogo Brain and Heart Center, Department of Radiology and Nuclear Medicine, Himeji, Hyogo (Japan); Shimada, Kenichi; Ohkawa, Shingo [Hyogo Brain and Heart Center, Institute for Aging Brain and Cognitive Disorders, Himeji, Hyogo (Japan); Minoshima, Satoshi [University of Washington, Radiology and Bioengineering, Department of Radiology, Seattle, WA (United States)

    2009-05-15

    To develop a computer-assisted automated diagnostic system to distinguish among Alzheimer disease (AD), dementia with Lewy bodies (DLB), and other degenerative disorders in patients with mild dementia. Single photon emission computed tomography (SPECT) images with injection of N-Isopropyl-p-[{sup 123}I]iodoamphetamine (IMP) were obtained from patients with mild degenerative dementia. First, datasets from 20 patients mild AD, 15 patients with dementia with DLB, and 17 healthy controls were used to develop an automated diagnosing system based on three-dimensional stereotactic surface projections (3D-SSP). AD- and DLB-specific regional templates were created using 3D-SSP, and critical Z scores in the templates were established. Datasets from 50 AD patients, 8 DLB patients, and 10 patients with non-AD/DLB type degenerative dementia (5 with frontotemporal dementia and 5 with progressive supranuclear palsy) were then used to test the diagnostic accuracy of the optimized automated system in comparison to the diagnostic interpretation of conventional IMP-SPECT images. These comparisons were performed to differentiate AD and DLB from non-AD/DLB and to distinguish AD from DLB. A receiver operating characteristic (ROC) analysis was performed. The area under the ROC curve (Az) and the accuracy of the automated diagnosis system were 0.89 and 82%, respectively, for AD/DLB vs. non-AD/DLB patients, and 0.70 and 65%, respectively, for AD vs. DLB patients. The mean Az and the accuracy of the visual inspection were 0.84 and 77%, respectively, for AD/DLB vs. non-AD/DLB patients, and 0.70 and 65%, respectively, for AD vs. DLB patients. The mean Az and the accuracy of the combination of visual inspection and this system were 0.96 and 91%, respectively, for AD/DLB vs. non-AD/DLB patients, and 0.70 and 66%, respectively, for AD vs. DLB patients. The system developed in the present study achieved as good discrimination of AD, DLB, and other degenerative disorders in patients with mild

  4. Computer-assisted diagnostic system for neurodegenerative dementia using brain SPECT and 3D-SSP

    International Nuclear Information System (INIS)

    To develop a computer-assisted automated diagnostic system to distinguish among Alzheimer disease (AD), dementia with Lewy bodies (DLB), and other degenerative disorders in patients with mild dementia. Single photon emission computed tomography (SPECT) images with injection of N-Isopropyl-p-[123I]iodoamphetamine (IMP) were obtained from patients with mild degenerative dementia. First, datasets from 20 patients mild AD, 15 patients with dementia with DLB, and 17 healthy controls were used to develop an automated diagnosing system based on three-dimensional stereotactic surface projections (3D-SSP). AD- and DLB-specific regional templates were created using 3D-SSP, and critical Z scores in the templates were established. Datasets from 50 AD patients, 8 DLB patients, and 10 patients with non-AD/DLB type degenerative dementia (5 with frontotemporal dementia and 5 with progressive supranuclear palsy) were then used to test the diagnostic accuracy of the optimized automated system in comparison to the diagnostic interpretation of conventional IMP-SPECT images. These comparisons were performed to differentiate AD and DLB from non-AD/DLB and to distinguish AD from DLB. A receiver operating characteristic (ROC) analysis was performed. The area under the ROC curve (Az) and the accuracy of the automated diagnosis system were 0.89 and 82%, respectively, for AD/DLB vs. non-AD/DLB patients, and 0.70 and 65%, respectively, for AD vs. DLB patients. The mean Az and the accuracy of the visual inspection were 0.84 and 77%, respectively, for AD/DLB vs. non-AD/DLB patients, and 0.70 and 65%, respectively, for AD vs. DLB patients. The mean Az and the accuracy of the combination of visual inspection and this system were 0.96 and 91%, respectively, for AD/DLB vs. non-AD/DLB patients, and 0.70 and 66%, respectively, for AD vs. DLB patients. The system developed in the present study achieved as good discrimination of AD, DLB, and other degenerative disorders in patients with mild dementia

  5. 3D printing meets computational astrophysics: deciphering the structure of η Carinae's inner colliding winds

    Science.gov (United States)

    Madura, T. I.; Clementel, N.; Gull, T. R.; Kruip, C. J. H.; Paardekooper, J.-P.

    2015-06-01

    We present the first 3D prints of output from a supercomputer simulation of a complex astrophysical system, the colliding stellar winds in the massive (≳120 M⊙), highly eccentric (e ˜ 0.9) binary star system η Carinae. We demonstrate the methodology used to incorporate 3D interactive figures into a PDF (Portable Document Format) journal publication and the benefits of using 3D visualization and 3D printing as tools to analyse data from multidimensional numerical simulations. Using a consumer-grade 3D printer (MakerBot Replicator 2X), we successfully printed 3D smoothed particle hydrodynamics simulations of η Carinae's inner (r ˜ 110 au) wind-wind collision interface at multiple orbital phases. The 3D prints and visualizations reveal important, previously unknown `finger-like' structures at orbital phases shortly after periastron (φ ˜ 1.045) that protrude radially outwards from the spiral wind-wind collision region. We speculate that these fingers are related to instabilities (e.g. thin-shell, Rayleigh-Taylor) that arise at the interface between the radiatively cooled layer of dense post-shock primary-star wind and the fast (3000 km s-1), adiabatic post-shock companion-star wind. The success of our work and easy identification of previously unrecognized physical features highlight the important role 3D printing and interactive graphics can play in the visualization and understanding of complex 3D time-dependent numerical simulations of astrophysical phenomena.

  6. A new approach of building 3D visualization framework for multimodal medical images display and computed assisted diagnosis

    Science.gov (United States)

    Li, Zhenwei; Sun, Jianyong; Zhang, Jianguo

    2012-02-01

    As more and more CT/MR studies are scanning with larger volume of data sets, more and more radiologists and clinician would like using PACS WS to display and manipulate these larger data sets of images with 3D rendering features. In this paper, we proposed a design method and implantation strategy to develop 3D image display component not only with normal 3D display functions but also with multi-modal medical image fusion as well as compute-assisted diagnosis of coronary heart diseases. The 3D component has been integrated into the PACS display workstation of Shanghai Huadong Hospital, and the clinical practice showed that it is easy for radiologists and physicians to use these 3D functions such as multi-modalities' (e.g. CT, MRI, PET, SPECT) visualization, registration and fusion, and the lesion quantitative measurements. The users were satisfying with the rendering speeds and quality of 3D reconstruction. The advantages of the component include low requirements for computer hardware, easy integration, reliable performance and comfortable application experience. With this system, the radiologists and the clinicians can manipulate with 3D images easily, and use the advanced visualization tools to facilitate their work with a PACS display workstation at any time.

  7. Front-end vision and multi-scale image analysis multi-scale computer vision theory and applications, written in Mathematica

    CERN Document Server

    Romeny, Bart M Haar

    2008-01-01

    Front-End Vision and Multi-Scale Image Analysis is a tutorial in multi-scale methods for computer vision and image processing. It builds on the cross fertilization between human visual perception and multi-scale computer vision (`scale-space') theory and applications. The multi-scale strategies recognized in the first stages of the human visual system are carefully examined, and taken as inspiration for the many geometric methods discussed. All chapters are written in Mathematica, a spectacular high-level language for symbolic and numerical manipulations. The book presents a new and effective

  8. Detectability of hepatic tumors during 3D post-processed ultrafast cone-beam computed tomography

    Science.gov (United States)

    Paul, Jijo; Vogl, Thomas J.; Chacko, Annamma

    2015-10-01

    To evaluate hepatic tumor detection using ultrafast cone-beam computed tomography (UCBCT) cross-sectional and 3D post-processed image datasets. 657 patients were examined using UCBCT during hepatic transarterial chemoembolization (TACE), and data were collected retrospectively from January 2012 to September 2014. Tumor detectability, diagnostic ability, detection accuracy and sensitivity were examined for different hepatic tumors using UCBCT cross-sectional, perfusion blood volume (PBV) and UCBCT-MRI (magnetic resonance imaging) fused image datasets. Appropriate statistical tests were used to compare collected sample data. Fused image data showed the significantly higher (all P  color display. Fused image data produced 100% tumor sensitivity due to the simultaneous availability of MRI and UCBCT information during tumor diagnosis. Fused image data produced excellent hepatic tumor sensitivity, detectability and diagnostic ability compared to other datasets assessed. Fused image data is extremely reliable and useful compared to UCBCT cross-sectional or PBV image datasets to depict hepatic tumors during TACE. Partial anatomical visualization on cross-sectional images was compensated by fused image data during tumor diagnosis.

  9. High resolution 3D imaging of bump-bonds by means of synchrotron radiation computed laminography

    Science.gov (United States)

    Cecilia, A.; Hamann, E.; Koenig, T.; Xu, F.; Cheng, Y.; Helfen, L.; Ruat, M.; Scheel, M.; Zuber, M.; Baumbach, T.; Fauler, A.; Fiederle, M.

    2013-12-01

    During the flip-chip bonding process of a semiconductor sensor onto readout electronics, a formation of defects may take place, like solder joint displacements, voids, cracks, pores and bridges. This may result in blind spots on the detector, which are insensitive to photons and thus reduce the detector performance. In this work, the flip-chip interconnections of selected CdTe and GaAs Medipix detectors were investigated by synchrotron radiation computed laminography at a micrometer scale. The analysis of the volume rendering proved the presence of voids in the CdTe sensor flip-chip interconnections, with sizes between 3 μm and 9 μm. These voids can be harmful for the long term use of the device, because their presence weakens the adhesive strength between a contact and the readout electronics. Consequently, their formation needs to be avoided. The GaAs Medipix detectors investigated include two sensors that were produced with different flip-chip methods. The comparison of the 3D renderings of the bump-bond interconnections in the two GaAs sensors demonstrated the presence of a misalignment in the range of 5-12 μm between pixel passivation and bump-bonds in the detector produced with an older technique. In contrast to this, no misalignment was observed for the most recently produced detector. The only remarkable observation is the presence of ``satellites'' of solder that do not compromise the detector operation.

  10. Computer-assisted 3D kinematic analysis of all leg joints in walking insects.

    Directory of Open Access Journals (Sweden)

    John A Bender

    Full Text Available High-speed video can provide fine-scaled analysis of animal behavior. However, extracting behavioral data from video sequences is a time-consuming, tedious, subjective task. These issues are exacerbated where accurate behavioral descriptions require analysis of multiple points in three dimensions. We describe a new computer program written to assist a user in simultaneously extracting three-dimensional kinematics of multiple points on each of an insect's six legs. Digital video of a walking cockroach was collected in grayscale at 500 fps from two synchronized, calibrated cameras. We improved the legs' visibility by painting white dots on the joints, similar to techniques used for digitizing human motion. Compared to manual digitization of 26 points on the legs over a single, 8-second bout of walking (or 106,496 individual 3D points, our software achieved approximately 90% of the accuracy with 10% of the labor. Our experimental design reduced the complexity of the tracking problem by tethering the insect and allowing it to walk in place on a lightly oiled glass surface, but in principle, the algorithms implemented are extensible to free walking. Our software is free and open-source, written in the free language Python and including a graphical user interface for configuration and control. We encourage collaborative enhancements to make this tool both better and widely utilized.

  11. Real-time 3D computed tomographic reconstruction using commodity graphics hardware

    Science.gov (United States)

    Xu, Fang; Mueller, Klaus

    2007-07-01

    The recent emergence of various types of flat-panel x-ray detectors and C-arm gantries now enables the construction of novel imaging platforms for a wide variety of clinical applications. Many of these applications require interactive 3D image generation, which cannot be satisfied with inexpensive PC-based solutions using the CPU. We present a solution based on commodity graphics hardware (GPUs) to provide these capabilities. While GPUs have been employed for CT reconstruction before, our approach provides significant speedups by exploiting the various built-in hardwired graphics pipeline components for the most expensive CT reconstruction task, backprojection. We show that the timings so achieved are superior to those obtained when using the GPU merely as a multi-processor, without a drop in reconstruction quality. In addition, we also show how the data flow across the graphics pipeline can be optimized, by balancing the load among the pipeline components. The result is a novel streaming CT framework that conceptualizes the reconstruction process as a steady flow of data across a computing pipeline, updating the reconstruction result immediately after the projections have been acquired. Using a single PC equipped with a single high-end commodity graphics board (the Nvidia 8800 GTX), our system is able to process clinically-sized projection data at speeds meeting and exceeding the typical flat-panel detector data production rates, enabling throughput rates of 40-50 projections s-1 for the reconstruction of 5123 volumes.

  12. Real-time 3D computed tomographic reconstruction using commodity graphics hardware

    Energy Technology Data Exchange (ETDEWEB)

    Xu Fang; Mueller, Klaus [Center for Visual Computing, Computer Science Department, Stony Brook University, Stony Brook, NY 11794-4400 (United States)

    2007-07-21

    The recent emergence of various types of flat-panel x-ray detectors and C-arm gantries now enables the construction of novel imaging platforms for a wide variety of clinical applications. Many of these applications require interactive 3D image generation, which cannot be satisfied with inexpensive PC-based solutions using the CPU. We present a solution based on commodity graphics hardware (GPUs) to provide these capabilities. While GPUs have been employed for CT reconstruction before, our approach provides significant speedups by exploiting the various built-in hardwired graphics pipeline components for the most expensive CT reconstruction task, backprojection. We show that the timings so achieved are superior to those obtained when using the GPU merely as a multi-processor, without a drop in reconstruction quality. In addition, we also show how the data flow across the graphics pipeline can be optimized, by balancing the load among the pipeline components. The result is a novel streaming CT framework that conceptualizes the reconstruction process as a steady flow of data across a computing pipeline, updating the reconstruction result immediately after the projections have been acquired. Using a single PC equipped with a single high-end commodity graphics board (the Nvidia 8800 GTX), our system is able to process clinically-sized projection data at speeds meeting and exceeding the typical flat-panel detector data production rates, enabling throughput rates of 40-50 projections s{sup -1} for the reconstruction of 512{sup 3} volumes.

  13. Performance Assessment of Three Rendering Engines in 3D Computer Graphics Software

    Directory of Open Access Journals (Sweden)

    Žan Vidmar

    2015-03-01

    Full Text Available The aim of the research was the determination of testing conditions and visual and numerical evaluation of renderings made with three different rendering engines in Maya software, which is widely used for educational and computer art purposes. In the theoretical part the overview of light phenomena and their simulation in virtual space is presented. This is followed by a detailed presentation of the main rendering methods and the results and limitations of their applications to 3D objects. At the end of the theoretical part the importance of a proper testing scene and especially the role of Cornell box are explained. In the experimental part the terms and conditions as well as hardware and software used for the research are presented. This is followed by a description of the procedures, where we focused on the rendering quality and time, which enabled the comparison of settings of different render engines and determination of conditions for further rendering of testing scenes. The experimental part continued with rendering a variety of simple virtual scenes including Cornell box and virtual object with different materials and colours. Apart from visual evaluation, which was the starting point for comparison of renderings, a procedure for numerical estimation and colour deviations of renderings using the selected regions of interest in the final images is presented.

  14. Craniosynostosis: prenatal diagnosis by 2D/3D ultrasound, magnetic resonance imaging and computed tomography.

    Science.gov (United States)

    Helfer, Talita Micheletti; Peixoto, Alberto Borges; Tonni, Gabriele; Araujo Júnior, Edward

    2016-09-01

    Craniosynostosis is defined as the process of premature fusion of one or more of the cranial sutures. It is a common condition that occurs in about 1 to 2,000 live births. Craniosynostosis may be classified in primary or secondary. It is also classified as nonsyndromic or syndromic. According to suture commitment, craniosynostosis may affect a single suture or multiple sutures. There is a wide range of syndromes involving craniosynostosis and the most common are Apert, Pffeifer, Crouzon, Shaethre-Chotzen and Muenke syndromes. The underlying etiology of nonsyndromic craniosynostosis is unknown. Mutations in the fibroblast growth factor (FGF) signalling pathway play a crucial role in the etiology of craniosynostosis syndromes. Prenatal ultrasound`s detection rate of craniosynostosis is low. Nowadays, different methods can be applied for prenatal diagnosis of craniosynostosis, such as two-dimensional (2D) and three-dimensional (3D) ultrasound, magnetic resonance imaging (MRI), computed tomography (CT) scan and, finally, molecular diagnosis. The presence of craniosynostosis may affect the birthing process. Fetuses with craniosynostosis also have higher rates of perinatal complications. In order to avoid the risks of untreated craniosynostosis, children are usually treated surgically soon after postnatal diagnosis. PMID:27622416

  15. Detectability of hepatic tumors during 3D post-processed ultrafast cone-beam computed tomography

    International Nuclear Information System (INIS)

    To evaluate hepatic tumor detection using ultrafast cone-beam computed tomography (UCBCT) cross-sectional and 3D post-processed image datasets.657 patients were examined using UCBCT during hepatic transarterial chemoembolization (TACE), and data were collected retrospectively from January 2012 to September 2014. Tumor detectability, diagnostic ability, detection accuracy and sensitivity were examined for different hepatic tumors using UCBCT cross-sectional, perfusion blood volume (PBV) and UCBCT–MRI (magnetic resonance imaging) fused image datasets. Appropriate statistical tests were used to compare collected sample data.Fused image data showed the significantly higher (all P  <  0.05) diagnostic ability for hepatic tumors compared to UCBCT or PBV image data. The detectability of small hepatic tumors (<5 mm) was significantly reduced (all P  <  0.05) using UCBCT cross-sectional images compared to MRI or fused image data; however, PBV improved tumor detectability using a color display. Fused image data produced 100% tumor sensitivity due to the simultaneous availability of MRI and UCBCT information during tumor diagnosis.Fused image data produced excellent hepatic tumor sensitivity, detectability and diagnostic ability compared to other datasets assessed. Fused image data is extremely reliable and useful compared to UCBCT cross-sectional or PBV image datasets to depict hepatic tumors during TACE. Partial anatomical visualization on cross-sectional images was compensated by fused image data during tumor diagnosis. (paper)

  16. Algorithms for Fast Computing of the 3D-DCT Transform

    Directory of Open Access Journals (Sweden)

    S. Hanus

    2003-04-01

    Full Text Available The algorithm for video compression based on the Three-DimensionalDiscrete Cosine Transform (3D-DCT is presented. The original algorithmof the 3D-DCT has high time complexity. We propose several enhancementsto the original algorithm and make the calculation of the DCT algorithmfeasible for future real-time video compression.

  17. Conversion and improvement of the Rutherford Laboratory's magnetostatic computer code GFUN3D to the NMFECC CDC 7600

    International Nuclear Information System (INIS)

    The implementation of a version of the Rutherford Laboratory's magnetostatic computer code GFUN3D on the CDC 7600 at the National Magnetic Fusion Energy Computer Center is reported. A new iteration technique that greatly increases the probability of convergence and reduces computation time by about 30% for calculations with nonlinear, ferromagnetic materials is included. The use of GFUN3D on the NMFE network is discussed, and suggestions for future work are presented. Appendix A consists of revisions to the GFUN3D User Guide (published by Rutherford Laboratory( that are necessary to use this version. Appendix B contains input and output for some sample calculations. Appendix C is a detailed discussion of the old and new iteration techniques

  18. 3D Printing Meets Computational Astrophysics: Deciphering the Structure of Eta Carinae's Inner Colliding Winds

    CERN Document Server

    Madura, Thomas I; Gull, Theodore R; Kruip, Chael J H; Paardekooper, Jan-Pieter

    2015-01-01

    We present the first 3D prints of output from a supercomputer simulation of a complex astrophysical system, the colliding stellar winds in the massive (>120 M_Sun), highly eccentric (e ~ 0.9) binary star system Eta Carinae. We demonstrate the methodology used to incorporate 3D interactive figures into a PDF journal publication and the benefits of using 3D visualization and 3D printing as tools to analyze data from multidimensional numerical simulations. Using a consumer-grade 3D printer (MakerBot Replicator 2X), we successfully printed 3D smoothed particle hydrodynamics (SPH) simulations of Eta Carinae's inner (r ~ 110 au) wind-wind collision interface at multiple orbital phases. The 3D prints and visualizations reveal important, previously unknown 'finger-like' structures at orbital phases shortly after periastron (phi ~ 1.045) that protrude radially outward from the spiral wind-wind collision region. We speculate that these fingers are related to instabilities (e.g. thin-shell, Rayleigh-Taylor) that arise a...

  19. Multi-scale computational framework for evaluating of the performance of molecular based flash cells

    OpenAIRE

    Georgiev, Vihar; Asenov, Asen

    2015-01-01

    In this work we present a multi-scale computational framework for evaluation of statistical variability in a molecular based non-volatile memory cell. As a test case we analyse a BULK flash cell with polyoxometalates (POM) inorganic molecules used as storage centres. We focuse our discussions on the methodology and development of our innovative and unique computational framework. The capability of the discussed multi-scale approach is demonstrated by establishing a link between the threshold ...

  20. Lagrangian Finite Element Method for 3D Time-Dependent Viscoelastic Flow Computations using Integral Models

    DEFF Research Database (Denmark)

    Rasmussen, Henrik Koblitz

    2000-01-01

    The 3D-LIM has as yet been used to simulate the following two three-dimensional problems. First, the method has been used to simulete for viscoelastic end-plate instability that occurs under certain conditions in the transient filament stretching apparatus for pressure sensitive adhesives...... (polymeric melts) and polymeric solutions. Secondly, the 3D-LIM has also been applied to calculate the inflation of a thick sheet of a polymer melt into an elliptic cylinder. These problems all include free surfaces. As the governing equations are solved for the particle positions, the motion of surfaces can...... be followed easily even in 3D viscoelastic flow....

  1. Computer numerical control (CNC) lithography: light-motion synchronized UV-LED lithography for 3D microfabrication

    International Nuclear Information System (INIS)

    This paper presents a computer-numerical-controlled ultraviolet light-emitting diode (CNC UV-LED) lithography scheme for three-dimensional (3D) microfabrication. The CNC lithography scheme utilizes sequential multi-angled UV light exposures along with a synchronized switchable UV light source to create arbitrary 3D light traces, which are transferred into the photosensitive resist. The system comprises a switchable, movable UV-LED array as a light source, a motorized tilt-rotational sample holder, and a computer-control unit. System operation is such that the tilt-rotational sample holder moves in a pre-programmed routine, and the UV-LED is illuminated only at desired positions of the sample holder during the desired time period, enabling the formation of complex 3D microstructures. This facilitates easy fabrication of complex 3D structures, which otherwise would have required multiple manual exposure steps as in the previous multidirectional 3D UV lithography approach. Since it is batch processed, processing time is far less than that of the 3D printing approach at the expense of some reduction in the degree of achievable 3D structure complexity. In order to produce uniform light intensity from the arrayed LED light source, the UV-LED array stage has been kept rotating during exposure. UV-LED 3D fabrication capability was demonstrated through a plurality of complex structures such as V-shaped micropillars, micropanels, a micro-‘hi’ structure, a micro-‘cat’s claw,’ a micro-‘horn,’ a micro-‘calla lily,’ a micro-‘cowboy’s hat,’ and a micro-‘table napkin’ array. (paper)

  2. Computer numerical control (CNC) lithography: light-motion synchronized UV-LED lithography for 3D microfabrication

    Science.gov (United States)

    Kim, Jungkwun; Yoon, Yong-Kyu; Allen, Mark G.

    2016-03-01

    This paper presents a computer-numerical-controlled ultraviolet light-emitting diode (CNC UV-LED) lithography scheme for three-dimensional (3D) microfabrication. The CNC lithography scheme utilizes sequential multi-angled UV light exposures along with a synchronized switchable UV light source to create arbitrary 3D light traces, which are transferred into the photosensitive resist. The system comprises a switchable, movable UV-LED array as a light source, a motorized tilt-rotational sample holder, and a computer-control unit. System operation is such that the tilt-rotational sample holder moves in a pre-programmed routine, and the UV-LED is illuminated only at desired positions of the sample holder during the desired time period, enabling the formation of complex 3D microstructures. This facilitates easy fabrication of complex 3D structures, which otherwise would have required multiple manual exposure steps as in the previous multidirectional 3D UV lithography approach. Since it is batch processed, processing time is far less than that of the 3D printing approach at the expense of some reduction in the degree of achievable 3D structure complexity. In order to produce uniform light intensity from the arrayed LED light source, the UV-LED array stage has been kept rotating during exposure. UV-LED 3D fabrication capability was demonstrated through a plurality of complex structures such as V-shaped micropillars, micropanels, a micro-‘hi’ structure, a micro-‘cat’s claw,’ a micro-‘horn,’ a micro-‘calla lily,’ a micro-‘cowboy’s hat,’ and a micro-‘table napkin’ array.

  3. Conceptual detector development and Monte Carlo simulation of a novel 3D breast computed tomography system

    Science.gov (United States)

    Ziegle, Jens; Müller, Bernhard H.; Neumann, Bernd; Hoeschen, Christoph

    2016-03-01

    A new 3D breast computed tomography (CT) system is under development enabling imaging of microcalcifications in a fully uncompressed breast including posterior chest wall tissue. The system setup uses a steered electron beam impinging on small tungsten targets surrounding the breast to emit X-rays. A realization of the corresponding detector concept is presented in this work and it is modeled through Monte Carlo simulations in order to quantify first characteristics of transmission and secondary photons. The modeled system comprises a vertical alignment of linear detectors hold by a case that also hosts the breast. Detectors are separated by gaps to allow the passage of X-rays towards the breast volume. The detectors located directly on the opposite side of the gaps detect incident X-rays. Mechanically moving parts in an imaging system increase the duration of image acquisition and thus can cause motion artifacts. So, a major advantage of the presented system design is the combination of the fixed detectors and the fast steering electron beam which enable a greatly reduced scan time. Thereby potential motion artifacts are reduced so that the visualization of small structures such as microcalcifications is improved. The result of the simulation of a single projection shows high attenuation by parts of the detector electronics causing low count levels at the opposing detectors which would require a flat field correction, but it also shows a secondary to transmission ratio of all counted X-rays of less than 1 percent. Additionally, a single slice with details of various sizes was reconstructed using filtered backprojection. The smallest detail which was still visible in the reconstructed image has a size of 0.2mm.

  4. 3D printing of preclinical X-ray computed tomographic data sets.

    Science.gov (United States)

    Doney, Evan; Krumdick, Lauren A; Diener, Justin M; Wathen, Connor A; Chapman, Sarah E; Stamile, Brian; Scott, Jeremiah E; Ravosa, Matthew J; Van Avermaete, Tony; Leevy, W Matthew

    2013-03-22

    Three-dimensional printing allows for the production of highly detailed objects through a process known as additive manufacturing. Traditional, mold-injection methods to create models or parts have several limitations, the most important of which is a difficulty in making highly complex products in a timely, cost-effective manner.(1) However, gradual improvements in three-dimensional printing technology have resulted in both high-end and economy instruments that are now available for the facile production of customized models.(2) These printers have the ability to extrude high-resolution objects with enough detail to accurately represent in vivo images generated from a preclinical X-ray CT scanner. With proper data collection, surface rendering, and stereolithographic editing, it is now possible and inexpensive to rapidly produce detailed skeletal and soft tissue structures from X-ray CT data. Even in the early stages of development, the anatomical models produced by three-dimensional printing appeal to both educators and researchers who can utilize the technology to improve visualization proficiency. (3, 4) The real benefits of this method result from the tangible experience a researcher can have with data that cannot be adequately conveyed through a computer screen. The translation of pre-clinical 3D data to a physical object that is an exact copy of the test subject is a powerful tool for visualization and communication, especially for relating imaging research to students, or those in other fields. Here, we provide a detailed method for printing plastic models of bone and organ structures derived from X-ray CT scans utilizing an Albira X-ray CT system in conjunction with PMOD, ImageJ, Meshlab, Netfabb, and ReplicatorG software packages.

  5. A new cone-beam computed tomography system for dental applications with innovative 3D software

    Energy Technology Data Exchange (ETDEWEB)

    Pasini, Alessandro; Bianconi, D.; Rossi, A. [University of Bologna, Department of Physics, Bologna (Italy); NECTAR Imaging srl Imola (Italy); Casali, F. [University of Bologna, Department of Physics, Bologna (Italy); Bontempi, M. [CEFLA Dental Group Imola (Italy)

    2007-02-15

    Objective Cone beam computed tomography (CBCT) is an important image technique for oral surgery (dentoalveolar surgery and dental implantology) and maxillofacial applications. This technique requires compact sized scanners with a relatively low radiation dosage, which makes them suitable for imaging of the craniofacial region. This article aims to present the concept and the preliminary findings obtained with the prototype of a new CBCT scanner with dedicated 3D software, specifically designed for dental imaging. Methods The prototype implements an X-ray tube with a nominal focal spot of 0.5 mm operating at 70-100 kVp and 1-4 mA. The detector is a 6 in. image intensifier coupled with a digital CCD camera. Dosimetry was performed on a RANDO anthropomorphic phantom using Beryllium Oxide thermo-luminescent dosimeters positioned in the phantom in the following site: eyes, thyroid, skin (lips, cheeks, back of the neck), brain, mandible, maxilla and parotid glands. Doses were measured using four configurations, changing the field-of-view (4'' and 6'') and acquisition time (10 and 20 s) of the CBCT. Acquisitions were performed with different parameters regarding the x-ray tube, pixel size and acquisition geometries to evaluate image quality in relation to modulation transfer function (MTF), noise and geometric accuracy. Results The prototype was able to acquire a complete maxillofacial scan in 10-15 s. The CT reconstruction algorithm delivered images that were judged to have high quality, allowing for precise volume rendering. The radiation dose was determined to be 1-1.5 times that of the dose applied during conventional dental panoramic studies. Conclusion Preliminary studies using the CBCT prototype indicate that this device provides images with acceptable diagnostic content at a relatively low radiation dosage, if compared to systems currently available on the market. (orig.)

  6. A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

    OpenAIRE

    Nowell, Mark; Rodionov, Roman; Zombori, Gergely; Sparks, Rachel; Rizzi, Michele; Ourselin, Sebastien; Miserocchi, Anna; McEvoy, Andrew; Duncan, John

    2016-01-01

    Epilepsy surgery is challenging and the use of 3D multimodality image integration (3DMMI) to aid presurgical planning is well-established. Multimodality image integration can be technically demanding, and is underutilised in clinical practice. We have developed a single software platform for image integration, 3D visualization and surgical planning. Here, our pipeline is described in step-by-step fashion, starting with image acquisition, proceeding through image co-registration, manual segmen...

  7. VELOCITY FIELD COMPUTATION IN VIBRATED GRANULAR MEDIA USING AN OPTICAL FLOW BASED MULTISCALE IMAGE ANALYSIS METHOD

    Directory of Open Access Journals (Sweden)

    Johan Debayle

    2011-05-01

    Full Text Available An image analysis method has been developed in order to compute the velocity field of a granular medium (sand grains, mean diameter 600 μm submitted to different kinds of mechanical stresses. The differential method based on optical flow conservation consists in describing a dense motion field with vectors associated to each pixel. A multiscale, coarse-to-fine, analytical approach through tailor sized windows yields the best compromise between accuracy and robustness of the results, while enabling an acceptable computation time. The corresponding algorithmis presented and its validation discussed through different tests. The results of the validation tests of the proposed approach show that the method is satisfactory when attributing specific values to parameters in association with the size of the image analysis window. An application in the case of vibrated sand has been studied. An instrumented laboratory device provides sinusoidal vibrations and enables external optical observations of sand motion in 3D transparent boxes. At 50 Hz, by increasing the relative acceleration G, the onset and development of two convective rolls can be observed. An ultra fast camera records the grain avalanches, and several pairs of images are analysed by the proposed method. The vertical velocity profiles are deduced and allow to precisely quantify the dimensions of the fluidized region as a function of G.

  8. Development, Verification and Use of Gust Modeling in the NASA Computational Fluid Dynamics Code FUN3D

    Science.gov (United States)

    Bartels, Robert E.

    2012-01-01

    This paper presents the implementation of gust modeling capability in the CFD code FUN3D. The gust capability is verified by computing the response of an airfoil to a sharp edged gust. This result is compared with the theoretical result. The present simulations will be compared with other CFD gust simulations. This paper also serves as a users manual for FUN3D gust analyses using a variety of gust profiles. Finally, the development of an Auto-Regressive Moving-Average (ARMA) reduced order gust model using a gust with a Gaussian profile in the FUN3D code is presented. ARMA simulated results of a sequence of one-minus-cosine gusts is shown to compare well with the same gust profile computed with FUN3D. Proper Orthogonal Decomposition (POD) is combined with the ARMA modeling technique to predict the time varying pressure coefficient increment distribution due to a novel gust profile. The aeroelastic response of a pitch/plunge airfoil to a gust environment is computed with a reduced order model, and compared with a direct simulation of the system in the FUN3D code. The two results are found to agree very well.

  9. KNOW-BLADE task-3.3 report: Rotor blade computations with 3D vortex generators

    DEFF Research Database (Denmark)

    Johansen, J.; Sørensen, Niels N.; Reck, M.;

    2005-01-01

    of the partners have modelled the airfoil section as a thin airfoil section with symmetry boundary conditions in the span wise direction to simulate anarray of VGs. The wind turbine blade is the LM19.1 blade equipped with one pair of VGs placed at radius = 8.5 m. In general all partners have successfully modelled...... vortex generators in 3D, which eventually generates vortices and mixes the boundary layer.A large effort has been on generating the numerical meshes since this is a relatively complex configuration and a large variation of length and time scales is present. Even though the quantitative agreement......The present report describes the work done in work package WP3.3: Aerodynamic Accessories in 3D in the EC project KNOW-BLADE. Vortex generators (VGs) are modelled in 3D Navier-Stokes solvers and applied on the flow around an airfoil and a wind turbineblade. Three test cases have been investigated...

  10. A collaborative computing framework of cloud network and WBSN applied to fall detection and 3-D motion reconstruction.

    Science.gov (United States)

    Lai, Chin-Feng; Chen, Min; Pan, Jeng-Shyang; Youn, Chan-Hyun; Chao, Han-Chieh

    2014-03-01

    As cloud computing and wireless body sensor network technologies become gradually developed, ubiquitous healthcare services prevent accidents instantly and effectively, as well as provides relevant information to reduce related processing time and cost. This study proposes a co-processing intermediary framework integrated cloud and wireless body sensor networks, which is mainly applied to fall detection and 3-D motion reconstruction. In this study, the main focuses includes distributed computing and resource allocation of processing sensing data over the computing architecture, network conditions and performance evaluation. Through this framework, the transmissions and computing time of sensing data are reduced to enhance overall performance for the services of fall events detection and 3-D motion reconstruction.

  11. Accuracy and reliability of measurements obtained from computed tomography 3D volume rendered images.

    Science.gov (United States)

    Stull, Kyra E; Tise, Meredith L; Ali, Zabiullah; Fowler, David R

    2014-05-01

    Forensic pathologists commonly use computed tomography (CT) images to assist in determining the cause and manner of death as well as for mass disaster operations. Even though the design of the CT machine does not inherently produce distortion, most techniques within anthropology rely on metric variables, thus concern exists regarding the accuracy of CT images reflecting an object's true dimensions. Numerous researchers have attempted to validate the use of CT images, however the comparisons have only been conducted on limited elements and/or comparisons were between measurements taken from a dry element and measurements taken from the 3D-CT image of the same dry element. A full-body CT scan was performed prior to autopsy at the Office of the Chief Medical Examiner for the State of Maryland. Following autopsy, the remains were processed to remove all soft tissues and the skeletal elements were subject to an additional CT scan. Percent differences and Bland-Altman plots were used to assess the accuracy between osteometric variables obtained from the dry skeletal elements and from CT images with and without soft tissues. An additional seven crania were scanned, measured by three observers, and the reliability was evaluated by technical error of measurement (TEM) and relative technical error of measurement (%TEM). Average percent differences between the measurements obtained from the three data sources ranged from 1.4% to 2.9%. Bland-Altman plots illustrated the two sets of measurements were generally within 2mm for each comparison between data sources. Intra-observer TEM and %TEM for three observers and all craniometric variables ranged between 0.46mm and 0.77mm and 0.56% and 1.06%, respectively. The three-way inter-observer TEM and %TEM for craniometric variables was 2.6mm and 2.26%, respectively. Variables that yielded high error rates were orbital height, orbital breadth, inter-orbital breadth and parietal chord. Overall, minimal differences were found among the

  12. Evaluation of the durability of 3D printed keys produced by computational processing of image data

    Science.gov (United States)

    Straub, Jeremy; Kerlin, Scott

    2016-05-01

    Possession of a working 3D printed key can, for most practical purposes, convince observers that an illicit attempt to gain premises access is authorized. This paper seeks to assess three things. First, work has been performed to determine how easily the data for making models of keys can be obtained through manual measurement. It then presents work done to create a model of the key and determine how easy key modeling could be (particularly after a first key of a given key `blank' has been made). Finally, it seeks to assess the durability of the keys produced using 3D printing.

  13. 3D Printing Meets Computational Astrophysics: Deciphering the Structure of Eta Carinae’s Colliding Winds Using 3D Prints of Smoothed Particle Hydrodynamics Simulations

    Science.gov (United States)

    Madura, Thomas; Gull, Theodore R.; Clementel, Nicola; Paardekooper, Jan-Pieter; Kruip, Chael; Corcoran, Michael F.; Hamaguchi, Kenji; Teodoro, Mairan

    2015-01-01

    We present the first 3D prints of output from a supercomputer simulation of a complex astrophysical system, the colliding stellar winds in the massive (>120 MSun), highly eccentric (e ~ 0.9) binary Eta Carinae. Using a consumer-grade 3D printer (Makerbot Replicator 2X), we successfully printed 3D smoothed particle hydrodynamics simulations of Eta Carinae's inner (r ~110 AU) wind-wind collision interface at multiple orbital phases. These 3D prints reveal important, previously unknown 'finger-like' structures at orbital phases shortly after periastron (φ ~1.045) that protrude radially outward from the spiral wind-wind collision region. We speculate that these fingers are related to instabilities (e.g. Rayleigh-Taylor) that arise at the interface between the radiatively-cooled layer of dense post-shock primary-star wind and the hot, adiabatic post-shock companion-star wind. The success of our work and easy identification of previously unknown physical features highlight the important role 3D printing can play in the visualization and understanding of complex 3D time-dependent numerical simulations of astrophysical phenomena.

  14. TBIEM3D: A Computer Program for Predicting Ducted Fan Engine Noise. Version 1.1

    Science.gov (United States)

    Dunn, M. H.

    1997-01-01

    This document describes the usage of the ducted fan noise prediction program TBIEM3D (Thin duct - Boundary Integral Equation Method - 3 Dimensional). A scattering approach is adopted in which the acoustic pressure field is split into known incident and unknown scattered parts. The scattering of fan-generated noise by a finite length circular cylinder in a uniform flow field is considered. The fan noise is modeled by a collection of spinning point thrust dipoles. The program, based on a Boundary Integral Equation Method (BIEM), calculates circumferential modal coefficients of the acoustic pressure at user-specified field locations. The duct interior can be of the hard wall type or lined. The duct liner is axisymmetric, locally reactive, and can be uniform or axially segmented. TBIEM3D is written in the FORTRAN programming language. Input to TBIEM3D is minimal and consists of geometric and kinematic parameters. Discretization and numerical parameters are determined automatically by the code. Several examples are presented to demonstrate TBIEM3D capabilities.

  15. Computer system to manage information rigs by 3D electronic models; Sistema computacional para administrar la informacion de plataformas petroleras mediante modelos electronicos 3D

    Energy Technology Data Exchange (ETDEWEB)

    Vazquez Bustos, Jesus; Segura Ozuna, Victor Octavio [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)

    2012-06-22

    The evolution and incorporation of new hardware technologies, as well as recent advances in computer systems have enabled the development of applications of computer aided design of most complete scope, such as those used for the design of industrial process plants. This article describes a software system developed to complement the capabilities of one of these systems for the design of process plants. A 3D electronic model is generated through the user interface of the design system that at the same time gives the user the ability to generate, publish, review and control the engineering document that are generated during the entire life cycle of a marine oil platform, a very particular type of industrial process plant. This way, the user obtains not only a tool for the design of an industrial plant, but also a system for managing information and engineering documents that are developed. This allows the user to do a more efficient job by putting at his disposal and in the same system, all documents and information required to perform his duty. [Spanish] La evolucion e incorporacion de nuevas tecnologias de hardware, junto con los avances recientes en sistemas de computo ha permitido el desarrollo de aplicaciones de interesante diseno de computo de mayor alcance, tales como los que se emplean en las plantas de procesos industriales. Este articulo describe un sistema de software desarrollado para complementar las capacidades de uno de estos sistemas para el diseno de proceso. Un modelo electronico se genera por medio de la interfaz de usuario del sistema de diseno, que al mismo tiempo da al usuario la capacidad para crear, publicar, revisar y controlar los documentos de ingenieria que se producen durante el ciclo de vida completo de una plataforma marina petrolera, un tipo muy particular de planta de proceso industrial. De este modo, el usuario no solo obtiene una herramienta para el diseno de una planta industrial, sino tambien un sistema para manejar informacion y

  16. Computer-aided diagnosis of pulmonary nodules on CT scans: Segmentation and classification using 3D active contours

    International Nuclear Information System (INIS)

    We are developing a computer-aided diagnosis (CAD) system to classify malignant and benign lung nodules found on CT scans. A fully automated system was designed to segment the nodule from its surrounding structured background in a local volume of interest (VOI) and to extract image features for classification. Image segmentation was performed with a three-dimensional (3D) active contour (AC) method. A data set of 96 lung nodules (44 malignant, 52 benign) from 58 patients was used in this study. The 3D AC model is based on two-dimensional AC with the addition of three new energy components to take advantage of 3D information: (1) 3D gradient, which guides the active contour to seek the object surface (2) 3D curvature, which imposes a smoothness constraint in the z direction, and (3) mask energy, which penalizes contours that grow beyond the pleura or thoracic wall. The search for the best energy weights in the 3D AC model was guided by a simplex optimization method. Morphological and gray-level features were extracted from the segmented nodule. The rubber band straightening transform (RBST) was applied to the shell of voxels surrounding the nodule. Texture features based on run-length statistics were extracted from the RBST image. A linear discriminant analysis classifier with stepwise feature selection was designed using a second simplex optimization to select the most effective features. Leave-one-case-out resampling was used to train and test the CAD system. The system achieved a test area under the receiver operating characteristic curve (Az) of 0.83±0.04. Our preliminary results indicate that use of the 3D AC model and the 3D texture features surrounding the nodule is a promising approach to the segmentation and classification of lung nodules with CAD. The segmentation performance of the 3D AC model trained with our data set was evaluated with 23 nodules available in the Lung Image Database Consortium (LIDC). The lung nodule volumes segmented by the 3D AC

  17. Generating 3D anatomically detailed models of the retina from OCT data sets: implications for computational modelling

    Science.gov (United States)

    Shalbaf, Farzaneh; Dokos, Socrates; Lovell, Nigel H.; Turuwhenua, Jason; Vaghefi, Ehsan

    2015-12-01

    Retinal prosthesis has been proposed to restore vision for those suffering from the retinal pathologies that mainly affect the photoreceptors layer but keep the inner retina intact. Prior to costly risky experimental studies computational modelling of the retina will help to optimize the device parameters and enhance the outcomes. Here, we developed an anatomically detailed computational model of the retina based on OCT data sets. The consecutive OCT images of individual were subsequently segmented to provide a 3D representation of retina in the form of finite elements. Thereafter, the electrical properties of the retina were modelled by implementing partial differential equation on the 3D mesh. Different electrode configurations, that is bipolar and hexapolar configurations, were implemented and the results were compared with the previous computational and experimental studies. Furthermore, the possible effects of the curvature of retinal layers on the current steering through the retina were proposed and linked to the clinical observations.

  18. Computer-aided multiple-head 3D printing system for printing of heterogeneous organ/tissue constructs

    Science.gov (United States)

    Jung, Jin Woo; Lee, Jung-Seob; Cho, Dong-Woo

    2016-02-01

    Recently, much attention has focused on replacement or/and enhancement of biological tissues via the use of cell-laden hydrogel scaffolds with an architecture that mimics the tissue matrix, and with the desired three-dimensional (3D) external geometry. However, mimicking the heterogeneous tissues that most organs and tissues are formed of is challenging. Although multiple-head 3D printing systems have been proposed for fabricating heterogeneous cell-laden hydrogel scaffolds, to date only the simple exterior form has been realized. Here we describe a computer-aided design and manufacturing (CAD/CAM) system for this application. We aim to develop an algorithm to enable easy, intuitive design and fabrication of a heterogeneous cell-laden hydrogel scaffolds with a free-form 3D geometry. The printing paths of the scaffold are automatically generated from the 3D CAD model, and the scaffold is then printed by dispensing four materials; i.e., a frame, two kinds of cell-laden hydrogel and a support. We demonstrated printing of heterogeneous tissue models formed of hydrogel scaffolds using this approach, including the outer ear, kidney and tooth tissue. These results indicate that this approach is particularly promising for tissue engineering and 3D printing applications to regenerate heterogeneous organs and tissues with tailored geometries to treat specific defects or injuries.

  19. Use of micro computed-tomography and 3D printing for reverse engineering of mouse embryo nasal capsule

    International Nuclear Information System (INIS)

    Imaging of increasingly complex cartilage in vertebrate embryos is one of the key tasks of developmental biology. This is especially important to study shape-organizing processes during initial skeletal formation and growth. Advanced imaging techniques that are reflecting biological needs give a powerful impulse to push the boundaries of biological visualization. Recently, techniques for contrasting tissues and organs have improved considerably, extending traditional 2D imaging approaches to 3D . X-ray micro computed tomography (μCT), which allows 3D imaging of biological objects including their internal structures with a resolution in the micrometer range, in combination with contrasting techniques seems to be the most suitable approach for non-destructive imaging of embryonic developing cartilage. Despite there are many software-based ways for visualization of 3D data sets, having a real solid model of the studied object might give novel opportunities to fully understand the shape-organizing processes in the developing body. In this feasibility study we demonstrated the full procedure of creating a real 3D object of mouse embryo nasal capsule, i.e. the staining, the μCT scanning combined by the advanced data processing and the 3D printing

  20. A computational model that recovers the 3D shape of an object from a single 2D retinal representation.

    Science.gov (United States)

    Li, Yunfeng; Pizlo, Zygmunt; Steinman, Robert M

    2009-05-01

    Human beings perceive 3D shapes veridically, but the underlying mechanisms remain unknown. The problem of producing veridical shape percepts is computationally difficult because the 3D shapes have to be recovered from 2D retinal images. This paper describes a new model, based on a regularization approach, that does this very well. It uses a new simplicity principle composed of four shape constraints: viz., symmetry, planarity, maximum compactness and minimum surface. Maximum compactness and minimum surface have never been used before. The model was tested with random symmetrical polyhedra. It recovered their 3D shapes from a single randomly-chosen 2D image. Neither learning, nor depth perception, was required. The effectiveness of the maximum compactness and the minimum surface constraints were measured by how well the aspect ratio of the 3D shapes was recovered. These constraints were effective; they recovered the aspect ratio of the 3D shapes very well. Aspect ratios recovered by the model were compared to aspect ratios adjusted by four human observers. They also adjusted aspect ratios very well. In those rare cases, in which the human observers showed large errors in adjusted aspect ratios, their errors were very similar to the errors made by the model. PMID:18621410

  1. Identification and classification in le fort type fractures by using 2D and 3D computed tomography

    Institute of Scientific and Technical Information of China (English)

    CHEN We-jian; YANG Yun-jun; FANG Yi-ming; XU Fang-hong; ZHANG Lin; CAO Guo-quan

    2006-01-01

    Objective:To evaluate the usefulness of twodimensional (2D) and three-dimensional (3D) computed tomography (CT) in the identification and classification of Le Fort type fractures.Methods: Sixty-two patients with different types of Le Fort fractures underwent CT scanning and 3D-CT reconstruction. The data were analyzed by multiplanar reconstruction (MPR), surface shaded display (SSD) and volume rendering (VR) respectively.Results: The patients with Le Fort Ⅰ , Le Fort Ⅱfracture and Le Fort Ⅲ fracture accounted for 16.1%,14.5 % and 12.9 % respectively. The compound fractures were the most common type and accounted for 56.5 % ( n =35, 18 cases with Le Fort Ⅰ + Ⅱ fracture, 10 cases with Le Fort Ⅱ + Ⅲ fracture and 7 cases with Le Fort Ⅰ + Ⅱ + Ⅲfracture). Fifty-five cases coexisted with other fractures in maxillofacial region. 2D-CT could be used to define the tiny fractures and the deep-structure fractures more accurately compared with 3D-CT, but the real impression of Le Fort type fractures could not be correctly evaluated on 2D-CT.3D-CT could clearly demonstrate the whole shape of Le Fort type fractures and identify the classification of Le Fort fractures.Conclusions: 3D-CT is the best imaging method for the diagnosis of Le Fort type fractures and can provide valuable information of space relationship, especially for the design of treatment plan before operation.

  2. Use of micro computed-tomography and 3D printing for reverse engineering of mouse embryo nasal capsule

    Science.gov (United States)

    Tesařová, M.; Zikmund, T.; Kaucká, M.; Adameyko, I.; Jaroš, J.; Paloušek, D.; Škaroupka, D.; Kaiser, J.

    2016-03-01

    Imaging of increasingly complex cartilage in vertebrate embryos is one of the key tasks of developmental biology. This is especially important to study shape-organizing processes during initial skeletal formation and growth. Advanced imaging techniques that are reflecting biological needs give a powerful impulse to push the boundaries of biological visualization. Recently, techniques for contrasting tissues and organs have improved considerably, extending traditional 2D imaging approaches to 3D . X-ray micro computed tomography (μCT), which allows 3D imaging of biological objects including their internal structures with a resolution in the micrometer range, in combination with contrasting techniques seems to be the most suitable approach for non-destructive imaging of embryonic developing cartilage. Despite there are many software-based ways for visualization of 3D data sets, having a real solid model of the studied object might give novel opportunities to fully understand the shape-organizing processes in the developing body. In this feasibility study we demonstrated the full procedure of creating a real 3D object of mouse embryo nasal capsule, i.e. the staining, the μCT scanning combined by the advanced data processing and the 3D printing.

  3. Computer-aided multiple-head 3D printing system for printing of heterogeneous organ/tissue constructs.

    Science.gov (United States)

    Jung, Jin Woo; Lee, Jung-Seob; Cho, Dong-Woo

    2016-02-22

    Recently, much attention has focused on replacement or/and enhancement of biological tissues via the use of cell-laden hydrogel scaffolds with an architecture that mimics the tissue matrix, and with the desired three-dimensional (3D) external geometry. However, mimicking the heterogeneous tissues that most organs and tissues are formed of is challenging. Although multiple-head 3D printing systems have been proposed for fabricating heterogeneous cell-laden hydrogel scaffolds, to date only the simple exterior form has been realized. Here we describe a computer-aided design and manufacturing (CAD/CAM) system for this application. We aim to develop an algorithm to enable easy, intuitive design and fabrication of a heterogeneous cell-laden hydrogel scaffolds with a free-form 3D geometry. The printing paths of the scaffold are automatically generated from the 3D CAD model, and the scaffold is then printed by dispensing four materials; i.e., a frame, two kinds of cell-laden hydrogel and a support. We demonstrated printing of heterogeneous tissue models formed of hydrogel scaffolds using this approach, including the outer ear, kidney and tooth tissue. These results indicate that this approach is particularly promising for tissue engineering and 3D printing applications to regenerate heterogeneous organs and tissues with tailored geometries to treat specific defects or injuries.

  4. Computational Approach in Formulating Mechanical Characteristics of 3D Star Honeycomb Auxetic Structure

    Directory of Open Access Journals (Sweden)

    Mozafar Shokri Rad

    2015-01-01

    Full Text Available Auxetic materials exhibit a unique characteristic due to the altered microstructure. Different structures have been used to model these materials. This paper treats a development of finite element model and theoretical formulation of 3D star honeycomb structure of these materials. Various shape parameters of the structural cell were evaluated with respect to the basic mechanical properties of the cell. Finite element and analytical approach for various geometrical parameters were numerically used to formulate the characteristics of the material. The study aims at quantifying mechanical properties for any domain in which auxetic material is of interest for variations in geometrical parameters. It is evident that mechanical properties of the material could be controlled by changing the base wall angle of the configuration. The primary outcome of the study is a design guideline for the use of 3D star honeycomb auxetic cellular structure in structural applications.

  5. Computer-aided diagnosis for osteoporosis using chest 3D CT images

    Science.gov (United States)

    Yoneda, K.; Matsuhiro, M.; Suzuki, H.; Kawata, Y.; Niki, N.; Nakano, Y.; Ohmatsu, H.; Kusumoto, M.; Tsuchida, T.; Eguchi, K.; Kaneko, M.

    2016-03-01

    The patients of osteoporosis comprised of about 13 million people in Japan and it is one of the problems the aging society has. In order to prevent the osteoporosis, it is necessary to do early detection and treatment. Multi-slice CT technology has been improving the three dimensional (3-D) image analysis with higher body axis resolution and shorter scan time. The 3-D image analysis using multi-slice CT images of thoracic vertebra can be used as a support to diagnose osteoporosis and at the same time can be used for lung cancer diagnosis which may lead to early detection. We develop automatic extraction and partitioning algorithm for spinal column by analyzing vertebral body structure, and the analysis algorithm of the vertebral body using shape analysis and a bone density measurement for the diagnosis of osteoporosis. Osteoporosis diagnosis support system obtained high extraction rate of the thoracic vertebral in both normal and low doses.

  6. Reliability of clinically relevant 3D foot bone angles from quantitative computed tomography

    OpenAIRE

    Gutekunst, David J; Liu, Lu; Ju, Tao; Prior, Fred W.; Sinacore, David R

    2013-01-01

    Background Surgical treatment and clinical management of foot pathology requires accurate, reliable assessment of foot deformities. Foot and ankle deformities are multi-planar and therefore difficult to quantify by standard radiographs. Three-dimensional (3D) imaging modalities have been used to define bone orientations using inertial axes based on bone shape, but these inertial axes can fail to mimic established bone angles used in orthopaedics and clinical biomechanics. To provide improved ...

  7. KNOW-BLADE task-3.3 report. Rotor blade computations with 3D vortex generators

    Energy Technology Data Exchange (ETDEWEB)

    Johansen, J.; Soerensen, N.N.; Reck, M. (and others)

    2005-01-01

    The present report describes the work done in work package WP3.3: Aerodynamic Accessories in 3D in the EC project KNOW-BLADE. Vortex generators (VGs) are modelled in 3D Navier-Stokes solvers and applied on the flow around an airfoil and a wind turbine blade. Three test cases have been investigated. They are: 1) A non-rotating airfoil section with VGs. 2) A rotating airfoil section with VGs. 3) A non-rotating wind turbine blade with VGs. The airfoil section was the FFA-W3-241 airfoil, which has been measured in the VELUX wind tunnel with and without VGs placed at different chord wise positions. Three of the partners have modelled the airfoil section as a thin airfoil section with symmetry boundary conditions in the span wise direction to simulate an array of VGs. The wind turbine blade is the LM19.1 blade equipped with one pair of VGs placed at radius = 8.5 m. In general all partners have successfully modelled vortex generators in 3D, which eventually generates vortices and mixes the boundary layer. A large effort has been on generating the numerical meshes since this is a relatively complex configuration and a large variation of length and time scales is present. Even though the quantitative agreement with measurements is not acceptable the effort spend in the present project indicate that it is possible to investigate the effect of vortex generators on wind turbine blades using 3D Navier-Stokes solvers. Much further work within independence of mesh resolution and time step as well as turbulence modelling has to be carried out in future projects before parametric variations can be investigated. (au)

  8. A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery.

    Science.gov (United States)

    Nowell, Mark; Rodionov, Roman; Zombori, Gergely; Sparks, Rachel; Rizzi, Michele; Ourselin, Sebastien; Miserocchi, Anna; McEvoy, Andrew; Duncan, John

    2016-01-01

    Epilepsy surgery is challenging and the use of 3D multimodality image integration (3DMMI) to aid presurgical planning is well-established. Multimodality image integration can be technically demanding, and is underutilised in clinical practice. We have developed a single software platform for image integration, 3D visualization and surgical planning. Here, our pipeline is described in step-by-step fashion, starting with image acquisition, proceeding through image co-registration, manual segmentation, brain and vessel extraction, 3D visualization and manual planning of stereoEEG (SEEG) implantations. With dissemination of the software this pipeline can be reproduced in other centres, allowing other groups to benefit from 3DMMI. We also describe the use of an automated, multi-trajectory planner to generate stereoEEG implantation plans. Preliminary studies suggest this is a rapid, safe and efficacious adjunct for planning SEEG implantations. Finally, a simple solution for the export of plans and models to commercial neuronavigation systems for implementation of plans in the operating theater is described. This software is a valuable tool that can support clinical decision making throughout the epilepsy surgery pathway.

  9. A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

    Science.gov (United States)

    Nowell, Mark; Rodionov, Roman; Zombori, Gergely; Sparks, Rachel; Rizzi, Michele; Ourselin, Sebastien; Miserocchi, Anna; McEvoy, Andrew; Duncan, John

    2016-01-01

    Epilepsy surgery is challenging and the use of 3D multimodality image integration (3DMMI) to aid presurgical planning is well-established. Multimodality image integration can be technically demanding, and is underutilised in clinical practice. We have developed a single software platform for image integration, 3D visualization and surgical planning. Here, our pipeline is described in step-by-step fashion, starting with image acquisition, proceeding through image co-registration, manual segmentation, brain and vessel extraction, 3D visualization and manual planning of stereoEEG (SEEG) implantations. With dissemination of the software this pipeline can be reproduced in other centres, allowing other groups to benefit from 3DMMI. We also describe the use of an automated, multi-trajectory planner to generate stereoEEG implantation plans. Preliminary studies suggest this is a rapid, safe and efficacious adjunct for planning SEEG implantations. Finally, a simple solution for the export of plans and models to commercial neuronavigation systems for implementation of plans in the operating theater is described. This software is a valuable tool that can support clinical decision making throughout the epilepsy surgery pathway. PMID:27286266

  10. 2nd International Conference on Multiscale Computational Methods for Solids and Fluids

    CERN Document Server

    2016-01-01

    This volume contains the best papers presented at the 2nd ECCOMAS International Conference on Multiscale Computations for Solids and Fluids, held June 10-12, 2015. Topics dealt with include multiscale strategy for efficient development of scientific software for large-scale computations, coupled probability-nonlinear-mechanics problems and solution methods, and modern mathematical and computational setting for multi-phase flows and fluid-structure interaction. The papers consist of contributions by six experts who taught short courses prior to the conference, along with several selected articles from other participants dealing with complementary issues, covering both solid mechanics and applied mathematics. .

  11. Tuneable resolution as a systems biology approach for multi-scale, multi-compartment computational models.

    Science.gov (United States)

    Kirschner, Denise E; Hunt, C Anthony; Marino, Simeone; Fallahi-Sichani, Mohammad; Linderman, Jennifer J

    2014-01-01

    The use of multi-scale mathematical and computational models to study complex biological processes is becoming increasingly productive. Multi-scale models span a range of spatial and/or temporal scales and can encompass multi-compartment (e.g., multi-organ) models. Modeling advances are enabling virtual experiments to explore and answer questions that are problematic to address in the wet-lab. Wet-lab experimental technologies now allow scientists to observe, measure, record, and analyze experiments focusing on different system aspects at a variety of biological scales. We need the technical ability to mirror that same flexibility in virtual experiments using multi-scale models. Here we present a new approach, tuneable resolution, which can begin providing that flexibility. Tuneable resolution involves fine- or coarse-graining existing multi-scale models at the user's discretion, allowing adjustment of the level of resolution specific to a question, an experiment, or a scale of interest. Tuneable resolution expands options for revising and validating mechanistic multi-scale models, can extend the longevity of multi-scale models, and may increase computational efficiency. The tuneable resolution approach can be applied to many model types, including differential equation, agent-based, and hybrid models. We demonstrate our tuneable resolution ideas with examples relevant to infectious disease modeling, illustrating key principles at work.

  12. Computation of thermal properties via 3D homogenization of multiphase materials using FFT-based accelerated scheme

    CERN Document Server

    Lemaitre, Sophie; Choi, Daniel; Karamian, Philippe

    2015-01-01

    In this paper we study the thermal effective behaviour for 3D multiphase composite material consisting of three isotropic phases which are the matrix, the inclusions and the coating media. For this purpose we use an accelerated FFT-based scheme initially proposed in Eyre and Milton (1999) to evaluate the thermal conductivity tensor. Matrix and spherical inclusions media are polymers with similar properties whereas the coating medium is metallic hence better conducting. Thus, the contrast between the coating and the others media is very large. For our study, we use RVEs (Representative volume elements) generated by RSA (Random Sequential Adsorption) method developed in our previous works, then, we compute effective thermal properties using an FFT-based homogenization technique validated by comparison with the direct finite elements method. We study the thermal behaviour of the 3D-multiphase composite material and we show what features should be taken into account to make the computational approach efficient.

  13. Implementation of Grid-computing Framework for Simulation in Multi-scale Structural Analysis

    Directory of Open Access Journals (Sweden)

    Data Iranata

    2010-05-01

    Full Text Available A new grid-computing framework for simulation in multi-scale structural analysis is presented. Two levels of parallel processing will be involved in this framework: multiple local distributed computing environments connected by local network to form a grid-based cluster-to-cluster distributed computing environment. To successfully perform the simulation, a large-scale structural system task is decomposed into the simulations of a simplified global model and several detailed component models using various scales. These correlated multi-scale structural system tasks are distributed among clusters and connected together in a multi-level hierarchy and then coordinated over the internet. The software framework for supporting the multi-scale structural simulation approach is also presented. The program architecture design allows the integration of several multi-scale models as clients and servers under a single platform. To check its feasibility, a prototype software system has been designed and implemented to perform the proposed concept. The simulation results show that the software framework can increase the speedup performance of the structural analysis. Based on this result, the proposed grid-computing framework is suitable to perform the simulation of the multi-scale structural analysis.

  14. Implementation of Headtracking and 3D Stereo with Unity and VRPN for Computer Simulations

    Science.gov (United States)

    Noyes, Matthew A.

    2013-01-01

    This paper explores low-cost hardware and software methods to provide depth cues traditionally absent in monocular displays. The use of a VRPN server in conjunction with a Microsoft Kinect and/or Nintendo Wiimote to provide head tracking information to a Unity application, and NVIDIA 3D Vision for retinal disparity support, is discussed. Methods are suggested to implement this technology with NASA's EDGE simulation graphics package, along with potential caveats. Finally, future applications of this technology to astronaut crew training, particularly when combined with an omnidirectional treadmill for virtual locomotion and NASA's ARGOS system for reduced gravity simulation, are discussed.

  15. World's first ABWR start-up test analysis with 3-D transient computational code

    International Nuclear Information System (INIS)

    The Kashiwazaki-Kariwa Nuclear Power Station Unit 6, the world's first Advanced BWR (ABWR), began commercial operation from November 1996 following one year of start-up tests. A large number of variables which may be used to validate the advanced design features were obtained from transient tests. These test data are now being used for the qualification of TRACG, a BWR 3-D transient analysis code. Calculated results show that TRACG is fully capable of accurately predicting ABWR transient response and will be useful for application to future plant designs

  16. Computer Simulation of Flow in CSO “OK3D Evropská”

    OpenAIRE

    Pollert, J

    2000-01-01

    During the last 30 years, a number of devices has been developed for dynamic separation of settle able solids in wastewaters. Initially, these separators were used for control of Combined Sewer Overflow (CSO) pollution by retaining the bulk of solids in the underflow, directed to the sewage treatment plant (STP), and allowing combined sewage with reduced pollutant loads to overflow from the sewer systém. This paper is describing CSO “OK 3D Evropská” in Prague 6 on Evropská Street. Inlet...

  17. Isoparametric 3-D Finite Element Mesh Generation Using Interactive Computer Graphics

    Science.gov (United States)

    Kayrak, C.; Ozsoy, T.

    1985-01-01

    An isoparametric 3-D finite element mesh generator was developed with direct interface to an interactive geometric modeler program called POLYGON. POLYGON defines the model geometry in terms of boundaries and mesh regions for the mesh generator. The mesh generator controls the mesh flow through the 2-dimensional spans of regions by using the topological data and defines the connectivity between regions. The program is menu driven and the user has a control of element density and biasing through the spans and can also apply boundary conditions, loads interactively.

  18. Numerical computation of critical properties and atomic basins from 3D grid electron densities

    CERN Document Server

    Katan, C; Lecomte, C; Guezo, M; Oison, V; Souhassou, M

    2003-01-01

    InteGriTy is a software package that performs topological analysis following AIM approach on electron densities given on 3D grids. Use of tricubic interpolation is made to get the density, its gradient and hessian matrix at any required position. Critical points and integrated atomic properties have been derived from theoretical densities calculated for the compounds NaCl and TTF-2,5Cl2BQ, thus covering the different kinds of chemical bonds: ionic, covalent, hydrogen bonds and other intermolecular contacts.

  19. 3D game engine design a practical approach to real-time computer graphics

    CERN Document Server

    Eberly, David H

    2006-01-01

    A major revision of the international bestseller on game programming!Graphics hardware has evolved enormously in the last decade. Hardware can now be directly controlled through techniques such as shader programming, which requires an entirely new thought process of a programmer. 3D Game Engine Design, Second Edition shows step-by-step how to make a shader-based graphics engine and how to tame the new technology. Much new material has been added, including more than twice the coverage of the essential techniques of scene graph management, as well as new methods for manag

  20. The role of computer-aided design in the learning of practical 3D-descriptive geometry: a case study

    OpenAIRE

    Edwards, Geoffrey Alan

    1988-01-01

    There are a number of problems surrounding the teaching of practical 3-D descriptive geometry to children in secondary education, notably the difficulty pupils have with visualising an object's form from orthographic views, and the interpretation of an object's geometric attributes into the descriptive geometry representation. The purpose of the current research is to evaluate the use of computer-aided design in this area of the curriculum and is based upon work under...

  1. 3-D computational model of poly (lactic acid)/halloysite nanocomposites: Predicting elastic properties and stress analysis

    DEFF Research Database (Denmark)

    De Silva, R. T.; Pasbakhsh, Pooria; Goh, K. L.;

    2014-01-01

    A real-structure based 3-D micromechanical computational model of poly (lactic acid) nanocomposites reinforced by randomly oriented halloysite nanotubes (HNTs) was developed and compared with an idealized model (conventional model) and experimental results. The developed idealized model consists ...... and aspect ratios. Numerical studies were validated with experimental investigations and the developed real-structure based model gave more accurate results than idealized and analytical models. (C) 2014 Elsevier Ltd. All rights reserved....

  2. Linking Microscopic Spatial Patterns of Tissue Destruction in Emphysema to Macroscopic Decline in Stiffness Using a 3D Computational Model

    OpenAIRE

    Parameswaran, Harikrishnan; Majumdar, Arnab; Suki, Béla

    2011-01-01

    Pulmonary emphysema is a connective tissue disease characterized by the progressive destruction of alveolar walls leading to airspace enlargement and decreased elastic recoil of the lung. However, the relationship between microscopic tissue structure and decline in stiffness of the lung is not well understood. In this study, we developed a 3D computational model of lung tissue in which a pre-strained cuboidal block of tissue was represented by a tessellation of space filling polyhedra, with e...

  3. Linking microscopic spatial patterns of tissue destruction in emphysema to macroscopic decline in stiffness using a 3D computational model.

    OpenAIRE

    Harikrishnan Parameswaran; Arnab Majumdar; Béla Suki

    2011-01-01

    Pulmonary emphysema is a connective tissue disease characterized by the progressive destruction of alveolar walls leading to airspace enlargement and decreased elastic recoil of the lung. However, the relationship between microscopic tissue structure and decline in stiffness of the lung is not well understood. In this study, we developed a 3D computational model of lung tissue in which a pre-strained cuboidal block of tissue was represented by a tessellation of space filling polyhedra, with e...

  4. Scanning transmission and computer-aided volumic electron microscopy: 3-D modeling of entire cells by electronic imaging

    Science.gov (United States)

    Bron, Christophe; Gremillet, Philip; Launay, D.; Jourlin, Michel; Gautschi, H. P.; Baechi, Thomas; Schuepbach, Joerg

    1990-05-01

    The digital processing of electron microscopic images from serial sections containing laser-induced topographical references allows a 3-D reconstruction at a depth resolution of 30 to 40 nm of entire cells by the use of image analysis methods, as already demonstrated for Transmission Electron Microscopy (TEM) coupled with a video camera. We decided to use a Scanning Transmission Electron Microscope (STEM) to get higher contrast and better resolution at medium magnification. The scanning of our specimens at video frequencies is an attractive and easy way to link a STEM with an image processing system but the hysteresis of the electronic spools responsible for the magnetic deviation of the scanning electron beam induces deformations of images which have to be modelized and corrected before registration. Computer algorithms developed for image analysis and treatment correct the artifacts caused by the use of STEM and by serial sectioning to automatically reconstruct the third dimension of the cells. They permit the normalization of the images through logarithmic processing of the original grey level infonnation. The automatic extraction of cell limits allows to link the image analysis and treatments with image synthesis methods by minimal human intervention. The surface representation and the registered images provide an ultrastructural data base from which quantitative 3-D morphological parameters, as well as otherwise impossible visualizations, can be computed. This 3-D image processing named C.A.V.U.M. for Computer Aided Volumic Ultra-Microscopy offers a new tool for the documentation and analysis of cell ultrastructure and for 3-D morphometric studies at EM magnifications. Further, a virtual observer can be computed in such a way as to simulate a visit of the reconstructed object.

  5. Sentinel Lymph Node Detection by 3D Freehand Single-Photon Emission Computed Tomography in Early Stage Breast Cancer

    OpenAIRE

    Salih Sinan Gültekin; Ahmet Oğuz Hasdemir; Emine Öztürk

    2016-01-01

    We herein present our first experience obtained by 3D freehand single-photon emission computed tomography (SPECT) (F-SPECT) guidance for sentinel lymph node detection (SLND) in two patients with early stage breast cancer. F-SPECT guidance was carried out using one-day protocol in one case and by the two-day protocol in the other one. SLND was performed successfully in both patients. Histopathologic evaluation showed that the excised nodes were tumor negative. Thus, patients underw...

  6. Computing and monitoring potential of public spaces by shading analysis using 3d lidar data and advanced image analysis

    Science.gov (United States)

    Zwolinski, A.; Jarzemski, M.

    2015-04-01

    The paper regards specific context of public spaces in "shadow" of tall buildings located in European cities. Majority of tall buildings in European cities were built in last 15 years. Tall buildings appear mainly in city centres, directly at important public spaces being viable environment for inhabitants with variety of public functions (open spaces, green areas, recreation places, shops, services etc.). All these amenities and services are under direct impact of extensive shading coming from the tall buildings. The paper focuses on analyses and representation of impact of shading from tall buildings on various public spaces in cities using 3D city models. Computer environment of 3D city models in cityGML standard uses 3D LiDAR data as one of data types for definition of 3D cities. The structure of cityGML allows analytic applications using existing computer tools, as well as developing new techniques to estimate extent of shading coming from high-risers, affecting life in public spaces. These measurable shading parameters in specific time are crucial for proper functioning, viability and attractiveness of public spaces - finally it is extremely important for location of tall buildings at main public spaces in cities. The paper explores impact of shading from tall buildings in different spatial contexts on the background of using cityGML models based on core LIDAR data to support controlled urban development in sense of viable public spaces. The article is prepared within research project 2TaLL: Application of 3D Virtual City Models in Urban Analyses of Tall Buildings, realized as a part of Polish-Norway Grants.

  7. Novel low-cost 2D/3D switchable autostereoscopic system for notebook computers and other portable devices

    Science.gov (United States)

    Eichenlaub, Jesse B.

    1995-03-01

    Mounting a lenticular lens in front of a flat panel display is a well known, inexpensive, and easy way to create an autostereoscopic system. Such a lens produces half resolution 3D images because half the pixels on the LCD are seen by the left eye and half by the right eye. This may be acceptable for graphics, but it makes full resolution text, as displayed by common software, nearly unreadable. Very fine alignment tolerances normally preclude the possibility of removing and replacing the lens in order to switch between 2D and 3D applications. Lenticular lens based displays are therefore limited to use as dedicated 3D devices. DTI has devised a technique which removes this limitation, allowing switching between full resolution 2D and half resolution 3D imaging modes. A second element, in the form of a concave lenticular lens array whose shape is exactly the negative of the first lens, is mounted on a hinge so that it can be swung down over the first lens array. When so positioned the two lenses cancel optically, allowing the user to see full resolution 2D for text or numerical applications. The two lenses, having complementary shapes, naturally tend to nestle together and snap into perfect alignment when pressed together--thus obviating any need for user operated alignment mechanisms. This system represents an ideal solution for laptop and notebook computer applications. It was devised to meet the stringent requirements of a laptop computer manufacturer including very compact size, very low cost, little impact on existing manufacturing or assembly procedures, and compatibility with existing full resolution 2D text- oriented software as well as 3D graphics. Similar requirements apply to high and electronic calculators, several models of which now use LCDs for the display of graphics.

  8. Classification and quantification of pore shapes in sandstone reservoir rocks with 3-D X-ray micro-computed tomography

    Science.gov (United States)

    Schmitt, Mayka; Halisch, Matthias; Müller, Cornelia; Peres Fernandes, Celso

    2016-02-01

    Recent years have seen a growing interest in the characterization of the pore morphologies of reservoir rocks and how the spatial organization of pore traits affects the macro behavior of rock-fluid systems. With the availability of 3-D high-resolution imaging, such as x-ray micro-computed tomography (µ-CT), the detailed quantification of particle shapes has been facilitated by progress in computer science. Here, we show how the shapes of irregular rock particles (pores) can be classified and quantified based on binary 3-D images. The methodology requires the measurement of basic 3-D particle descriptors (length, width, and thickness) and a shape classification that involves the similarity of artificial objects, which is based on main pore network detachments and 3-D sample sizes. Two main pore components were identified from the analyzed volumes: pore networks and residual pore ganglia. A watershed algorithm was applied to preserve the pore morphology after separating the main pore networks, which is essential for the pore shape characterization. The results were validated for three sandstones (S1, S2, and S3) from distinct reservoirs, and most of the pore shapes were found to be plate- and cube-like, ranging from 39.49 to 50.94 % and from 58.80 to 45.18 % when the Feret caliper descriptor was investigated in a 10003 voxel volume. Furthermore, this study generalizes a practical way to correlate specific particle shapes, such as rods, blades, cuboids, plates, and cubes to characterize asymmetric particles of any material type with 3-D image analysis.

  9. Computer Simulation of Flow in CSO “OK3D Evropská”

    Directory of Open Access Journals (Sweden)

    J. Pollert

    2000-01-01

    Full Text Available During the last 30 years, a number of devices has been developed for dynamic separation of settle able solids in wastewaters. Initially, these separators were used for control of Combined Sewer Overflow (CSO pollution by retaining the bulk of solids in the underflow, directed to the sewage treatment plant (STP, and allowing combined sewage with reduced pollutant loads to overflow from the sewer systém. This paper is describing CSO “OK 3D Evropská” in Prague 6 on Evropská Street. Inlet to CSO is 3 m diameter tube collecting water from location of Oepy, Vokovice, Liboc and Ruzyně. The outflow throttle pipe is 1.1 m in diameter and continues to central wastewater treatment plant and overflow is ending in Šárecký creek. Šárecký creek flows through the Šárka valley which is environmentally protected area. CSO “OK 3D Evropská" has high overflow crest and probability of the function is 0.44 per year.

  10. 3D Quantification of Mandibular Asymmetry through Cone Beam Computed Tomography

    Science.gov (United States)

    Cevidanes, Lucia H.S.; Alhadidi, Abeer; Paniagua, Beatriz; Styner, Martin; Ludlow, John; Mol, Andre; Turvey, Timothy; Proffit, William R.; Rossouw, Paul Emile

    2011-01-01

    Objective To determine if 3D shape analysis precisely diagnoses right and left differences in asymmetry patients Study Design Cone-beam CT data was acquired pretreatment from 20 patients with mandibular asymmetry. 3D shape analysis was used to localize and quantify the extent of virtually simulated asymmetry. Two approaches were used: (1) mirroring on the midsagittal plane determined from landmarks and (2) mirroring on an arbitrary plane, then registering on the cranial base of the original image. The validation presented in this study used simulated data and has been applied to three clinical cases. Results For mirroring on the midsagittal plane there was a >99% probability that the difference between measured and simulated asymmetry was less than 0.5 mm. For mirroring with cranial base registration, there was a >84% probability of differences less than 0.5 mm. Conclusions Mandibular asymmetry can be precisely quantified with both mirroring methods. Cranial base registration has the potential to be used for patients with trauma situations or when key landmarks are unreliable or absent. PMID:21497527

  11. Fabrication of computationally designed scaffolds by low temperature 3D printing

    International Nuclear Information System (INIS)

    The development of artificial bone substitutes that mimic the properties of bone and simultaneously promote the desired tissue regeneration is a current issue in bone tissue engineering research. An approach to create scaffolds with such characteristics is based on the combination of novel design and additive manufacturing processes. The objective of this work is to characterize the microstructural and the mechanical properties of scaffolds developed by coupling both topology optimization and a low temperature 3D printing process. The scaffold design was obtained using a topology optimization approach to maximize the permeability with constraints on the mechanical properties. This procedure was studied to be suitable for the fabrication of a cage prototype for tibial tuberosity advancement application, which is one of the most recent and promising techniques to treat cruciate ligament rupture in dogs. The microstructural and mechanical properties of the scaffolds manufactured by reacting α/β-tricalcium phosphate with diluted phosphoric acid were then assessed experimentally and the scaffolds strength reliability was determined. The results demonstrate that the low temperature 3D printing process is a reliable option to create synthetic scaffolds with tailored properties, and when coupled with topology optimization design it can be a powerful tool for the fabrication of patient-specific bone implants. (paper)

  12. Advanced Multi-modal User Interfaces in 3D Computer Graphics and Virtual Reality

    OpenAIRE

    Chen, Yenan

    2012-01-01

    Computers are developed continuously to satisfy the human demands, and typical tools used everywhere for ranging from daily life usage to all kinds of research. Virtual Reality (VR), a virtual environment simulated to present physical presence in the real word and imaginary worlds, has been widely applied to simulate the virtual environment. People’s feeling is limited to visual perception when only computers are applied for simulations, since computers are limited to display visualization of...

  13. Casting directly from a computer model by using advanced simulation software FLOW-3D Cast ®

    Directory of Open Access Journals (Sweden)

    M. Sirviö

    2009-01-01

    Full Text Available ConiferRob - A patternless casting technique, originally conceived at VTT Technical Research Centre of Finland and furtherdeveloped at its spin-off company, Simtech Systems, offers up to 40% savings in product development costs, and up to two months shorterdevelopment times compared to conventional techniques. Savings of this order can be very valuable on today's highly competitivemarkets. Casting simulation is commonly used for designing of casting systems. However, most of the software are today old fashioned and predicting just shrinkage porosity. Flow Science, VTT and Simtech have developed new software called FLOW-3D Cast ® , whichcan simulate surface defects, air entrainment, filters, core gas problems and even a cavitation.

  14. Computational Finite Element Software Assisted Development of a 3D Inductively Coupled Power Transfer System

    Directory of Open Access Journals (Sweden)

    Pratik Raval

    2014-02-01

    Full Text Available To date inductively coupled power transfer (ICPT systems have already found many practical applications including battery charging pads. In fact, current charging platforms tend to largely support only one- or two-dimensional planar movement in load. This paper proposes a new concept of extending the aspect ratios of the operating power transfer volume of ICPT systems to support arbitrary three dimensional load movements with respect to the primary coils. This is done by use of modern finite element method analysis software to propose the primary and secondary magnetic structures of such an ICPT system. Firstly, two primary magnetic structures are proposed based on contrasting modes of operation and different field directions. This includes a single-phase and multi-phase current model. Next, a secondary magnetic structure is customized to be compatible with both primary structures. The resulting system is shown to produce a 3D power transfer volume for battery cell charging applications.

  15. Factors Affecting the Precision of Electrostatic Computation of 3D MEMS Structures

    CERN Document Server

    Majumdar, N

    2006-01-01

    Micro-Electro-Mechanical Systems (MEMS) normally have fixed or moving structures (plates or array of thin beams) with cross-sections of the order of microns and lengths of the order of tens or hundreds of microns. Electrostatic forces play a very major role in maneuvering these devices, and hence, a thorough understanding of the electrostatic properties of these structures is of critical importance. Recently, a nearly exact boundary element method (neBEM) solver has been developed and used to solve difficult problems related to electrostatics of various devices. Because of the exact foundation expressions, this solver has been found to be very accurate while solving critical problems which normally necessitate special formulations involving elegant, but difficult mathematics. In this work, we investigate the effects of various possible approximations on the 3D electrostatic solutions obtained for MEMS structures. In particular, we investigate the effects of discretization, omission of surfaces with small amou...

  16. A novel structured dictionary for fast processing of 3D medical images, with application to computed tomography restoration and denoising

    Science.gov (United States)

    Karimi, Davood; Ward, Rabab K.

    2016-03-01

    Sparse representation of signals in learned overcomplete dictionaries has proven to be a powerful tool with applications in denoising, restoration, compression, reconstruction, and more. Recent research has shown that learned overcomplete dictionaries can lead to better results than analytical dictionaries such as wavelets in almost all image processing applications. However, a major disadvantage of these dictionaries is that their learning and usage is very computationally intensive. In particular, finding the sparse representation of a signal in these dictionaries requires solving an optimization problem that leads to very long computational times, especially in 3D image processing. Moreover, the sparse representation found by greedy algorithms is usually sub-optimal. In this paper, we propose a novel two-level dictionary structure that improves the performance and the speed of standard greedy sparse coding methods. The first (i.e., the top) level in our dictionary is a fixed orthonormal basis, whereas the second level includes the atoms that are learned from the training data. We explain how such a dictionary can be learned from the training data and how the sparse representation of a new signal in this dictionary can be computed. As an application, we use the proposed dictionary structure for removing the noise and artifacts in 3D computed tomography (CT) images. Our experiments with real CT images show that the proposed method achieves results that are comparable with standard dictionary-based methods while substantially reducing the computational time.

  17. Efficient computation of steady, 3D water-wave patterns, application to hovercraft-type flows

    NARCIS (Netherlands)

    Lewis, M.R.; Koren, B.

    2002-01-01

    Numerical methods for the computation of stationary free surfaces is the subject of much current research in computational engineering. The present report is directed towards free surfaces in maritime engineering. Of interest here are the long steady waves generated by hovercraft and ships, the grav

  18. 3D CFD computations of trasitional flows using DES and a correlation based transition model

    DEFF Research Database (Denmark)

    Sørensen, Niels N.; Bechmann, Andreas; Zahle, Frederik

    2011-01-01

    The present article describes the application of the correlation based transition model of Menter et al. in combination with the Detached Eddy Simulation (DES) methodology to two cases with large degree of flow separation typically considered difficult to compute. Firstly, the flow is computed over...

  19. 3-D parallel program for numerical calculation of gas dynamics problems with heat conductivity on distributed memory computational systems (CS)

    Energy Technology Data Exchange (ETDEWEB)

    Sofronov, I.D.; Voronin, B.L.; Butnev, O.I. [VNIIEF (Russian Federation)] [and others

    1997-12-31

    The aim of the work performed is to develop a 3D parallel program for numerical calculation of gas dynamics problem with heat conductivity on distributed memory computational systems (CS), satisfying the condition of numerical result independence from the number of processors involved. Two basically different approaches to the structure of massive parallel computations have been developed. The first approach uses the 3D data matrix decomposition reconstructed at temporal cycle and is a development of parallelization algorithms for multiprocessor CS with shareable memory. The second approach is based on using a 3D data matrix decomposition not reconstructed during a temporal cycle. The program was developed on 8-processor CS MP-3 made in VNIIEF and was adapted to a massive parallel CS Meiko-2 in LLNL by joint efforts of VNIIEF and LLNL staffs. A large number of numerical experiments has been carried out with different number of processors up to 256 and the efficiency of parallelization has been evaluated in dependence on processor number and their parameters.

  20. Final Report for Integrated Multiscale Modeling of Molecular Computing Devices

    Energy Technology Data Exchange (ETDEWEB)

    Glotzer, Sharon C.

    2013-08-28

    In collaboration with researchers at Vanderbilt University, North Carolina State University, Princeton and Oakridge National Laboratory we developed multiscale modeling and simulation methods capable of modeling the synthesis, assembly, and operation of molecular electronics devices. Our role in this project included the development of coarse-grained molecular and mesoscale models and simulation methods capable of simulating the assembly of millions of organic conducting molecules and other molecular components into nanowires, crossbars, and other organized patterns.

  1. 3D hierarchical computational model of wood as a cellular material with fibril reinforced, heterogeneous multiple layers

    DEFF Research Database (Denmark)

    Qing, Hai; Mishnaevsky, Leon

    2009-01-01

    is presented as a 3D hexagon-shape-tube with multilayered walls. The layers in the softwood cell are considered as considered as composite reinforced by microfibrils (celluloses). The elastic properties of the layers are determined with Halpin–Tsai equations, and introduced into mesoscale finite element......A 3D hierarchical computational model of deformation and stiffness of wood, which takes into account the structures of wood at several scale levels (cellularity, multilayered nature of cell walls, composite-like structures of the wall layers) is developed. At the mesoscale, the softwood cell...... cellular model. With the use of the developed hierarchical model, the influence of the microstructure, including microfibril angles (MFAs, which characterizes the orientation of the cellulose fibrils with respect to the cell axis), the thickness of the cell wall, the shape of the cell cross...

  2. Progress in off-plane computer-generated waveguide holography for near-to-eye 3D display

    Science.gov (United States)

    Jolly, Sundeep; Savidis, Nickolaos; Datta, Bianca; Bove, V. Michael; Smalley, Daniel

    2016-03-01

    Waveguide holography refers to the use of holographic techniques for the control of guided-wave light in integrated optical devices (e.g., off-plane grating couplers and in-plane distributed Bragg gratings for guided-wave optical filtering). Off-plane computer-generated waveguide holography (CGWH) has also been employed in the generation of simple field distributions for image display. We have previously depicted the design and fabrication of a binary-phase CGWH operating in the Raman-Nath regime for the purposes of near-to-eye 3-D display and as a precursor to a dynamic, transparent flat-panel guided-wave holographic video display. In this paper, we describe design algorithms and fabrication techniques for multilevel phase CGWHs for near-to-eye 3-D display.

  3. A 3D edge detection technique for surface extraction in computed tomography for dimensional metrology applications

    DEFF Research Database (Denmark)

    Yagüe-Fabra, J.A.; Ontiveros, S.; Jiménez, R.;

    2013-01-01

    Many factors influence the measurement uncertainty when using computed tomography for dimensional metrology applications. One of the most critical steps is the surface extraction phase. An incorrect determination of the surface may significantly increase the measurement uncertainty. This paper...

  4. Petascale computation performance of lightweight multiscale cardiac models using hybrid programming models.

    Science.gov (United States)

    Pope, Bernard J; Fitch, Blake G; Pitman, Michael C; Rice, John J; Reumann, Matthias

    2011-01-01

    Future multiscale and multiphysics models must use the power of high performance computing (HPC) systems to enable research into human disease, translational medical science, and treatment. Previously we showed that computationally efficient multiscale models will require the use of sophisticated hybrid programming models, mixing distributed message passing processes (e.g. the message passing interface (MPI)) with multithreading (e.g. OpenMP, POSIX pthreads). The objective of this work is to compare the performance of such hybrid programming models when applied to the simulation of a lightweight multiscale cardiac model. Our results show that the hybrid models do not perform favourably when compared to an implementation using only MPI which is in contrast to our results using complex physiological models. Thus, with regards to lightweight multiscale cardiac models, the user may not need to increase programming complexity by using a hybrid programming approach. However, considering that model complexity will increase as well as the HPC system size in both node count and number of cores per node, it is still foreseeable that we will achieve faster than real time multiscale cardiac simulations on these systems using hybrid programming models. PMID:22254341

  5. Petascale computation performance of lightweight multiscale cardiac models using hybrid programming models.

    Science.gov (United States)

    Pope, Bernard J; Fitch, Blake G; Pitman, Michael C; Rice, John J; Reumann, Matthias

    2011-01-01

    Future multiscale and multiphysics models must use the power of high performance computing (HPC) systems to enable research into human disease, translational medical science, and treatment. Previously we showed that computationally efficient multiscale models will require the use of sophisticated hybrid programming models, mixing distributed message passing processes (e.g. the message passing interface (MPI)) with multithreading (e.g. OpenMP, POSIX pthreads). The objective of this work is to compare the performance of such hybrid programming models when applied to the simulation of a lightweight multiscale cardiac model. Our results show that the hybrid models do not perform favourably when compared to an implementation using only MPI which is in contrast to our results using complex physiological models. Thus, with regards to lightweight multiscale cardiac models, the user may not need to increase programming complexity by using a hybrid programming approach. However, considering that model complexity will increase as well as the HPC system size in both node count and number of cores per node, it is still foreseeable that we will achieve faster than real time multiscale cardiac simulations on these systems using hybrid programming models.

  6. Computed tomography study of VAPEX process in laboratory 3D model

    Energy Technology Data Exchange (ETDEWEB)

    Wu, G.Q.; Kantzas, A. [Calgary Univ., AB (Canada). Tomographic Imaging and Porous Media Laboratory; Salama, D. [Nexen Inc., Calgary, AB (Canada)

    2008-07-01

    This paper provided details of a 3-D laboratory model of the VAPEX process that used computerized tomography (CT) to examine vapour chamber expansion behaviour in longitudinal and radial directions. The model was comprised of an aluminum cylinder with 2 slotted tubes installed inside to act as injection and production wells. Propane was used as a solvent with heavy oil. The results of experiments conducted with the model showed that the V shape vapour chamber expansion pattern predicted by the 2-D model was a localized phenomenon. The dominant characteristic of the vapour chamber was an overriding of the injected solvent at the top of the model. The overriding was attributed to gravity segregation. The study also showed that longitudinal expansion was more significant than upwards expansion during the early stages of the VAPEX process. Oil production performance was then examined using different solvent injection rates. An analysis of the CT images was conducted to obtain model porosity, density, and oil saturation profiles. The study demonstrated that pressure cycles caused oil to be produced intermittently. Oil swelling by solvent gas dissolution was an important recovery mechanism. It was concluded that solvent soaking can be used to recover additional residual oil during the VAPEX process. 19 refs., 1 tab., 24 figs.

  7. Geometric Neural Computing for 2D Contour and 3D Surface Reconstruction

    Science.gov (United States)

    Rivera-Rovelo, Jorge; Bayro-Corrochano, Eduardo; Dillmann, Ruediger

    In this work we present an algorithm to approximate the surface of 2D or 3D objects combining concepts from geometric algebra and artificial neural networks. Our approach is based on the self-organized neural network called Growing Neural Gas (GNG), incorporating versors of the geometric algebra in its neural units; such versors are the transformations that will be determined during the training stage and then applied to a point to approximate the surface of the object. We also incorporate the information given by the generalized gradient vector flow to select automatically the input patterns, and also in the learning stage in order to improve the performance of the net. Several examples using medical images are presented, as well as images of automatic visual inspection. We compared the results obtained using snakes against the GSOM incorporating the gradient information and using versors. Such results confirm that our approach is very promising. As a second application, a kind of morphing or registration procedure is shown; namely the algorithm can be used when transforming one model at time t 1 into another at time t 2. We include also examples applying the same procedure, now extended to models based on spheres.

  8. 3-D Computer Animation vs. Live-Action Video: Differences in Viewers' Response to Instructional Vignettes

    Science.gov (United States)

    Smith, Dennie; McLaughlin, Tim; Brown, Irving

    2012-01-01

    This study explored computer animation vignettes as a replacement for live-action video scenarios of classroom behavior situations previously used as an instructional resource in teacher education courses in classroom management strategies. The focus of the research was to determine if the embedded behavioral information perceived in a live-action…

  9. Soft Computing Based Point Correspondence Matching for Automatic 3D Reconstruction

    Directory of Open Access Journals (Sweden)

    Annamária R. Várkonyi-Kóczy

    2005-06-01

    Full Text Available In computer vision image point correspondence matching plays an importantrole. With the help of the point correspondence matching algorithms for example some ofmethods concerning the field of stereo vision can be automatized. This paper presents amethod for quickly and reliably selecting and matching of the most interesting image points(feature points.

  10. Noise reduction in computed tomography scans using 3-d anisotropic hybrid diffusion with continuous switch.

    NARCIS (Netherlands)

    Mendrik, A.M.; Vonken, E.J.; Rutten, A.; Viergever, M.A.; Ginneken, B. van

    2009-01-01

    Noise filtering techniques that maintain image contrast while decreasing image noise have the potential to optimize the quality of computed tomography (CT) images acquired at reduced radiation dose. In this paper, a hybrid diffusion filter with continuous switch (HDCS) is introduced, which exploits

  11. A computational model for estimating tumor margins in complementary tactile and 3D ultrasound images

    Science.gov (United States)

    Shamsil, Arefin; Escoto, Abelardo; Naish, Michael D.; Patel, Rajni V.

    2016-03-01

    Conventional surgical methods are effective for treating lung tumors; however, they impose high trauma and pain to patients. Minimally invasive surgery is a safer alternative as smaller incisions are required to reach the lung; however, it is challenging due to inadequate intraoperative tumor localization. To address this issue, a mechatronic palpation device was developed that incorporates tactile and ultrasound sensors capable of acquiring surface and cross-sectional images of palpated tissue. Initial work focused on tactile image segmentation and fusion of position-tracked tactile images, resulting in a reconstruction of the palpated surface to compute the spatial locations of underlying tumors. This paper presents a computational model capable of analyzing orthogonally-paired tactile and ultrasound images to compute the surface circumference and depth margins of a tumor. The framework also integrates an error compensation technique and an algebraic model to align all of the image pairs and to estimate the tumor depths within the tracked thickness of a palpated tissue. For validation, an ex vivo experimental study was conducted involving the complete palpation of 11 porcine liver tissues injected with iodine-agar tumors of varying sizes and shapes. The resulting tactile and ultrasound images were then processed using the proposed model to compute the tumor margins and compare them to fluoroscopy based physical measurements. The results show a good negative correlation (r = -0.783, p = 0.004) between the tumor surface margins and a good positive correlation (r = 0.743, p = 0.009) between the tumor depth margins.

  12. A continuation method for computing non-linear 3-D free surface flows

    Energy Technology Data Exchange (ETDEWEB)

    Petersson, N.A.

    1993-01-01

    The subject of this paper is a pseudo-arclength continuation method for computing non-linear three-dimensional steady potential flow around a submerged body moving in a infinitely deep liquid at constant speed and distance below the free surface.

  13. Computational 3D structures of drug-targeting proteins in the 2009-H1N1 influenza A virus

    Science.gov (United States)

    Du, Qi-Shi; Wang, Shu-Qing; Huang, Ri-Bo; Chou, Kuo-Chen

    2010-01-01

    The neuraminidase (NA) and M2 proton channel of influenza virus are the drug-targeting proteins, based on which several drugs were developed. However these once powerful drugs encountered drug-resistant problem to the H5N1 and H1N1 flu. To address this problem, the computational 3D structures of NA and M2 proteins of 2009-H1N1 influenza virus were built using the molecular modeling technique and computational chemistry method. Based on the models the structure features of NA and M2 proteins were analyzed, the docking structures of drug-protein complexes were computed, and the residue mutations were annotated. The results may help to solve the drug-resistant problem and stimulate designing more effective drugs against 2009-H1N1 influenza pandemic.

  14. On the computation of long period seismograms in a 3-D earth using normal mode based approximations

    Science.gov (United States)

    Romanowicz, Barbara A.; Panning, Mark P.; Gung, Yuancheng; Capdeville, Yann

    2008-11-01

    Tomographic inversions for large-scale structure of the earth's mantle involve a forward modelling step of wave propagation through 3-D heterogeneity. Until now, most investigators have worked in the framework of the simplest theoretical assumptions, namely the infinite frequency `ray theory' in the case of body wave traveltime inversions, or the `path-average' approximation (PAVA) to normal mode perturbation theory, in the case of surface waves and long-period waveforms. As interest is shifting to mapping shorter wavelength structures, the need for a more accurate theoretical account of the interaction of seismic waves with mantle heterogeneity, coupled with improvements in path coverage, has been realized. Here we discuss different levels of approximations used in the context of normal mode perturbation theory, when modelling time domain seismic waveforms. We compare the performance of asymptotic approximations, which collapse the effects of 3-D structure onto the great circle vertical plane: the 1-D PAVA and a 2-D approximation called non-linear asymptotic coupling theory (NACT), which both are zeroth order asymptotic approximations. We then discuss how off-vertical plane effects can be introduced using higher order asymptotics. These computationally efficient approximations are compared to the linear Born formalism (BORN), which computes scattering integrals over the entire surface of the sphere. We point out some limitations of this linear formalism in the case of spatially extended anomalies, and show how that can be remedied through the introduction of a non-linear term (NBORN). All these approximations are referenced to a precise 3-D numerical computation afforded by the spectral element method. We discuss simple geometries, and explore a range of sizes of anomalies compared to the wavelength of the seismic waves considered, thus illustrating the range of validity and limitations of the various approximations considered.

  15. Sentinel Lymph Node Detection by 3D Freehand Single-Photon Emission Computed Tomography in Early Stage Breast Cancer

    Directory of Open Access Journals (Sweden)

    Salih Sinan Gültekin

    2016-06-01

    Full Text Available We herein present our first experience obtained by 3D freehand single-photon emission computed tomography (SPECT (F-SPECT guidance for sentinel lymph node detection (SLND in two patients with early stage breast cancer. F-SPECT guidance was carried out using one-day protocol in one case and by the two-day protocol in the other one. SLND was performed successfully in both patients. Histopathologic evaluation showed that the excised nodes were tumor negative. Thus, patients underwent breast-conserving surgery alone.

  16. How computer science can help in understanding the 3D genome architecture.

    Science.gov (United States)

    Shavit, Yoli; Merelli, Ivan; Milanesi, Luciano; Lio', Pietro

    2016-09-01

    Chromosome conformation capture techniques are producing a huge amount of data about the architecture of our genome. These data can provide us with a better understanding of the events that induce critical regulations of the cellular function from small changes in the three-dimensional genome architecture. Generating a unified view of spatial, temporal, genetic and epigenetic properties poses various challenges of data analysis, visualization, integration and mining, as well as of high performance computing and big data management. Here, we describe the critical issues of this new branch of bioinformatics, oriented at the comprehension of the three-dimensional genome architecture, which we call 'Nucleome Bioinformatics', looking beyond the currently available tools and methods, and highlight yet unaddressed challenges and the potential approaches that could be applied for tackling them. Our review provides a map for researchers interested in using computer science for studying 'Nucleome Bioinformatics', to achieve a better understanding of the biological processes that occur inside the nucleus.

  17. High-Performance Computation of Distributed-Memory Parallel 3D Voronoi and Delaunay Tessellation

    Energy Technology Data Exchange (ETDEWEB)

    Peterka, Tom; Morozov, Dmitriy; Phillips, Carolyn

    2014-11-14

    Computing a Voronoi or Delaunay tessellation from a set of points is a core part of the analysis of many simulated and measured datasets: N-body simulations, molecular dynamics codes, and LIDAR point clouds are just a few examples. Such computational geometry methods are common in data analysis and visualization; but as the scale of simulations and observations surpasses billions of particles, the existing serial and shared-memory algorithms no longer suffice. A distributed-memory scalable parallel algorithm is the only feasible approach. The primary contribution of this paper is a new parallel Delaunay and Voronoi tessellation algorithm that automatically determines which neighbor points need to be exchanged among the subdomains of a spatial decomposition. Other contributions include periodic and wall boundary conditions, comparison of our method using two popular serial libraries, and application to numerous science datasets.

  18. Computer-aided determination of occlusal contact points for dental 3-D CAD.

    Science.gov (United States)

    Maruyama, Tomoaki; Nakamura, Yasuo; Hayashi, Toyohiko; Kato, Kazumasa

    2006-05-01

    Present dental CAD systems enable us to design functional occlusal tooth surfaces which harmonize with the patient's stomatognathic function. In order to avoid occlusal interferences during tooth excursions, currently available systems usually use the patient's functional occlusal impressions for the design of occlusal contact points. Previous interfere-free design, however, has been done on a trial-and-error basis by using visual inspection. To improve this time-consuming procedure, this paper proposes a computer-aided system for assisting in the determination of the occlusal contact points by visualizing the appropriate regions of the opposing surface. The system can designate such regions from data of the opposing occlusal surfaces and their relative movements can be simulated by using a virtual articulator. Experiments for designing the crown of a lower first molar demonstrated that all contact points selected within the designated regions completely satisfied the required contact or separation during tooth excursions, confirming the effectiveness of our computer-aided procedure.

  19. Accurate computation of Galerkin double surface integrals in the 3-D boundary element method

    CERN Document Server

    Adelman, Ross; Duraiswami, Ramani

    2015-01-01

    Many boundary element integral equation kernels are based on the Green's functions of the Laplace and Helmholtz equations in three dimensions. These include, for example, the Laplace, Helmholtz, elasticity, Stokes, and Maxwell's equations. Integral equation formulations lead to more compact, but dense linear systems. These dense systems are often solved iteratively via Krylov subspace methods, which may be accelerated via the fast multipole method. There are advantages to Galerkin formulations for such integral equations, as they treat problems associated with kernel singularity, and lead to symmetric and better conditioned matrices. However, the Galerkin method requires each entry in the system matrix to be created via the computation of a double surface integral over one or more pairs of triangles. There are a number of semi-analytical methods to treat these integrals, which all have some issues, and are discussed in this paper. We present novel methods to compute all the integrals that arise in Galerkin fo...

  20. EVALUATION OF THE LIVER METASTASIS BY 3D-COMPUTED TOMOGRAPHY

    OpenAIRE

    Iuliana Eva; R.C. Tiutiuca

    2005-01-01

    Abdominal spiral computed tomography is the method of choice for the diagnosis of hepatic metastasis, evaluating lesions even under 10 mm. Treatment depends of the hepatic and extrahepatic spread of disease. Therapeutical options include surgical ablation (resection, enucleation, crioablation, radiofrequency, liver transplant) or non-surgical (embolization or chemoembolization, therapeutic aproach through the hepatic artery). Precise diagnostic and evaluation of the extension of the disease...

  1. 3-D finite element computation and dynamic modal analysis on ultrasonic vibration systems

    Institute of Scientific and Technical Information of China (English)

    倪金刚; 张学仁; 聂景旭(Department of Jet Propulsion 405; Beijing University of Aeronautics and Astronautics; Beijing 100083; China)

    1996-01-01

    Stress and modal analyses are performed on an ultrasonic vibration system by means of a 3-dimensional finite element computation and dynamic modal analysis code "Algor" The system consists of an edge-cracked specimen linked elastically with one or two amplifying horns which come into resonant longitudinal vibration at 20kHz.Operating principle of the ultrasonic fatigue machines and experimental procedures for ultrasonic fatigue crack growth studies are briefly presented.

  2. Computation of stationary 3D halo currents in fusion devices with accuracy control

    Science.gov (United States)

    Bettini, Paolo; Specogna, Ruben

    2014-09-01

    This paper addresses the calculation of the resistive distribution of halo currents in three-dimensional structures of large magnetic confinement fusion machines. A Neumann electrokinetic problem is solved on a geometry so complicated that complementarity is used to monitor the discretization error. An irrotational electric field is obtained by a geometric formulation based on the electric scalar potential, whereas three geometric formulations are compared to obtain a solenoidal current density: a formulation based on the electric vector potential and two geometric formulations inspired from mixed and mixed-hybrid Finite Elements. The electric vector potential formulation is usually considered impractical since an enormous computing power is wasted by the topological pre-processing it requires. To solve this challenging problem, we present novel algorithms based on lazy cohomology generators that enable to save orders of magnitude computational time with respect to all other state-of-the-art solutions proposed in literature. Believing that our results are useful in other fields of scientific computing, the proposed algorithm is presented as a detailed pseudocode in such a way that it can be easily implemented.

  3. Linearity of patient positioning detection. A phantom study of skin markers, cone beam computed tomography, and 3D ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    Ballhausen, Hendrik; Hieber, Sheila; Li, Minglun; Belka, Claus; Reiner, Michael [University Hospital of LMU, Department of Radiation Oncology, Munich (Germany); Parodi, Katia [Ludwig-Maximilian-University, Department of Experimental Physics - Medical Physics, Munich (Germany)

    2015-05-01

    Three-dimensional ultrasound (3D-US) is a modality complementary to kilovoltage cone beam computed tomography (kV-CBCT) and skin markers for patient positioning detection. This study compares the linearity of evaluations based on measurements using a modern 3D-US system (Elekta Clarity {sup registered}; Elekta, Stockholm, Sweden), a kV-CBCT system (Elekta iView {sup registered}), and skin markers. An investigator deliberately displaced a multimodal phantom by up to ± 30 mm along different axes. The following data points were acquired: 27 along the lateral axis, 29 along the longitudinal axis, 27 along the vertical axis, and 27 along the space diagonal. At each of these 110 positions, the displacements according to skin' markers were recorded and scans were performed using both 3D-US and kV-CBCT. Shifts were detected by matching bony anatomy or soft tissue density to a reference planning CT in the case of kV-CBCT and for 3D-US, by matching ultrasound volume data to a reference planning volume. A consensus value was calculated from the average of the four modalities. With respect to this consensus value, the linearity (offset and regression coefficient, i.e., slope), average offset, systematic error, and random error of all four modalities were calculated for each axis. Linearity was similar for all four modalities, with regression coefficients between 0.994 and 1.012, and all offsets below 1 mm. The systematic errors of skin markers and 3D-US were higher than for kV-CBCT, but random errors were similar. In particular, 3D-US demonstrated an average offset of 0.36 mm to the right, 0.08 mm inferiorly, and 0.15 mm anteriorly; the systematic error was 0.36 mm laterally, 0.35 mm longitudinally, and 0.22 mm vertically; the random error was 0.15 mm laterally, 0.30 mm longitudinally, and 0.12 mm vertically. A total of 109 out of 110 (99 %) 3D-US measurements were within 1 mm of the consensus value on either axis. The linearity of 3D-US was no worse than that of skin

  4. Simplified 3D model of a PWR reactor vessel using fluid dynamics code ANSYS CFX computational; Modelo simplificado 3D de la vasija de un reactor PWR mediante el codigo de dinamica de fluidos computacional ANSYS CFX

    Energy Technology Data Exchange (ETDEWEB)

    Martinez, M.; Miro, R.; Barrachina, T.; Verdu, G.

    2011-07-01

    This paper presents the results from the calculation of the steady state simulation with model of CFD (computational fluid dynamic) operating under conditions of operation at full power (Hot Full Power). Development and the CFD model results show the usefulness of these codes for calculating 3D of the variable thermohydraulics of these reactors.

  5. 3-D Cartesian Geometric Moment Computation using Morphological Operations and its Application to Object Classification

    OpenAIRE

    H. Sossa Azuela; F.J. Cuevas; C. Aguilar Ibañez; H. Benítez Muñoz

    2007-01-01

    Use of network al location costs by shift factors and MW-Mile method is re ported in this pa -per. Conventional shift factors are computed based on DC power flow. DC power flow re quires to selecting a slack busin order to avoid matrix singularity. There fore, shift fac tors are slack bus de pendent. In order to evade slack bus dependency, two approaches are considered Use of network al location costs by shift factors and MW-Mile method is reported in this paper. Conventional shift factors ar...

  6. ALGEBRAIC TURBULENCE MODEL WITH MEMORY FOR COMPUTATION OF 3-D TURBULENT BOUNDARY LAYERS WITH VALIDATION

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Additional equations were found based on experiments for an algebraic turbulence model to improve the prediction of the behavior of three dimensional turbulent boundary layers by taking account of the effects of pressure gradient and the historical variation of eddy viscosity, so the model is with memory. Numerical calculation by solving boundary layer equations was carried out for the five pressure driven three dimensional turbulent boundary layers developed on flat plates, swept-wing, and prolate spheroid in symmetrical plane. Comparing the computational results with the experimental data, it is obvious that the prediction will be more accurate if the proposed closure equations are used, especially for the turbulent shear stresses.

  7. Computer simulation of 2-D and 3-D ion beam extraction and acceleration

    Energy Technology Data Exchange (ETDEWEB)

    Ido, Shunji; Nakajima, Yuji [Saitama Univ., Urawa (Japan). Faculty of Engineering

    1997-03-01

    The two-dimensional code and the three-dimensional code have been developed to study the physical features of the ion beams in the extraction and acceleration stages. By using the two-dimensional code, the design of first electrode(plasma grid) is examined in regard to the beam divergence. In the computational studies by using the three-dimensional code, the axis-off model of ion beam is investigated. It is found that the deflection angle of ion beam is proportional to the gap displacement of the electrodes. (author)

  8. Computational studies of hard-body and 3-D effects in plume flows

    Science.gov (United States)

    Venkatapathy, Ethiraj; Feiereisen, William J.; Obayashi, Shigeru

    1989-01-01

    Axisymmetric and three-dimensional, multi-nozzle plume flows around generic rocket geometries are investigated with a three-dimensional Navier-Stokes solver to study the interactive effects between hard body and the plume. Time-asymptotic, laminar, ideal-gas solutions obtained with a two-factor, flux-split scheme and a diagonal, upwind scheme are presented. Computed solutions to three-dimensional, multi-nozzle problems and single-nozzle, axisymmetric problems demonstrate flow field features including three-dimensionality and hard-body effects. Geometry and three-dimensional effects are shown to be significant in multi-nozzle flows.

  9. Comparison of predicting drag methods using computational fluid dynamics in 2d/3d viscous flow

    Institute of Scientific and Technical Information of China (English)

    ZHU; ZiQiang; WANG; XiaoLu; LIU; Jie; LIU; Zhou

    2007-01-01

    As a result of the necessity of aircraft engineering design and the progress of computational fluid dynamics (CFD), techniques of accurately predicting aerodynamic drag are being increasingly explored. According to the momentum balance, the drag can be represented by an integral over a cross-flow plane (called wake integration method) at an arbitrary distance behind the configuration. A formulation to reduce the size of the wake cross plane region required for calculating the drag is developed by using cutoff parameters of vorticity and entropy. This increases the calculation accuracy and decreases the computation time required. Numerical experiments are made to obtain the threshold values of these cutoff parameters. The wake integration method is applied to predict drags of some examples including airfoil, a variety of wings and wing-body combination. Numerical results are compared with those of traditional surface integration method, showing that the predicting drag values with the wake integration method are closer to the experimental data. The results also show that drag prediction within engineering accuracy is possible by using CFD and the numerical drag optimization of complex aircraft configurations is possible, too.

  10. Performance of hybrid programming models for multiscale cardiac simulations: preparing for petascale computation.

    Science.gov (United States)

    Pope, Bernard J; Fitch, Blake G; Pitman, Michael C; Rice, John J; Reumann, Matthias

    2011-10-01

    Future multiscale and multiphysics models that support research into human disease, translational medical science, and treatment can utilize the power of high-performance computing (HPC) systems. We anticipate that computationally efficient multiscale models will require the use of sophisticated hybrid programming models, mixing distributed message-passing processes [e.g., the message-passing interface (MPI)] with multithreading (e.g., OpenMP, Pthreads). The objective of this study is to compare the performance of such hybrid programming models when applied to the simulation of a realistic physiological multiscale model of the heart. Our results show that the hybrid models perform favorably when compared to an implementation using only the MPI and, furthermore, that OpenMP in combination with the MPI provides a satisfactory compromise between performance and code complexity. Having the ability to use threads within MPI processes enables the sophisticated use of all processor cores for both computation and communication phases. Considering that HPC systems in 2012 will have two orders of magnitude more cores than what was used in this study, we believe that faster than real-time multiscale cardiac simulations can be achieved on these systems. PMID:21768044

  11. On a 3-D singularity element for computation of combined mode stress intensities

    Science.gov (United States)

    Atluri, S. N.; Kathiresan, K.

    1976-01-01

    A special three-dimensional singularity element is developed for the computation of combined modes 1, 2, and 3 stress intensity factors, which vary along an arbitrarily curved crack front in three dimensional linear elastic fracture problems. The finite element method is based on a displacement-hybrid finite element model, based on a modified variational principle of potential energy, with arbitrary element interior displacements, interelement boundary displacements, and element boundary tractions as variables. The special crack-front element used in this analysis contains the square root singularity in strains and stresses, where the stress-intensity factors K(1), K(2), and K(3) are quadratically variable along the crack front and are solved directly along with the unknown nodal displacements.

  12. 3D CFD computations of transitional flows using DES and a correlation based transition model

    DEFF Research Database (Denmark)

    Sørensen, Niels N.

    process can be important for the aerodynamic performance. Today, the most widespread approach is to use fully turbulent computations, where the transitional process is ignored and the entire boundary layer on the wings or airfoils is handled by the turbulence model. The correlation based transition model......The report describes the application of the correlation based transition model of of Menter et. al. [1, 2] to the cylinder drag crisis and the stalled flow over an DU-96-W-351 airfoil using the DES methodology. When predicting the flow over airfoils and rotors, the laminar-turbulent transition...... has lately shown promising results, and the present paper describes the application of the model to predict the drag and shedding frequency for flow around a cylinder from sub to super-critical Reynolds numbers. Additionally, the model is applied to the flow around the DU-96 airfoil, at high angles...

  13. Multiscale stochastic finite element method on random field modeling of geotechnical problems- a fast computing procedure

    Institute of Scientific and Technical Information of China (English)

    Xi F. XU

    2015-01-01

    The Green-function-based multiscale stochastic finite element method (MSFEM) has been formulated based on the stochastic variational principle. In this study a fast computing procedure based on the MSFEM is developed to solve random field geotechnical problems with a typical coefficient of variance less than 1. A unique fast computing advantage of the procedure enables computation performed only on those locations of interest, therefore saving a lot of computation. The numerical example on soil settlement shows that the procedure achieves significant computing efficiency compared with Monte Carlo method.

  14. Final Report. DOE Computational Nanoscience Project DE-FG02-03ER46096: Integrated Multiscale Modeling of Molecular Computing Devices

    Energy Technology Data Exchange (ETDEWEB)

    Cummings, Peter [Vanderbilt University

    2009-11-15

    The document is the final report of the DOE Computational Nanoscience Project DE-FG02-03ER46096: Integrated Multiscale Modeling of Molecular Computing Devices. It included references to 62 publications that were supported by the grant.

  15. Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study

    Directory of Open Access Journals (Sweden)

    Soojin Kang

    2015-01-01

    Full Text Available A cochlear implant (CI is an auditory prosthesis that enables hearing by providing electrical stimuli through an electrode array. It has been previously established that the electrode position can influence CI performance. Thus, electrode position should be considered in order to achieve better CI results. This paper describes how the electrode position influences the auditory nerve fiber (ANF response to either a single pulse or low- (250 pulses/s and high-rate (5,000 pulses/s pulse-trains using a computational model. The field potential in the cochlea was calculated using a three-dimensional finite-element model, and the ANF response was simulated using a biophysical ANF model. The effects were evaluated in terms of the dynamic range, stochasticity, and spike excitation pattern. The relative spread, threshold, jitter, and initiated node were analyzed for single-pulse response; and the dynamic range, threshold, initiated node, and interspike interval were analyzed for pulse-train stimuli responses. Electrode position was found to significantly affect the spatiotemporal pattern of the ANF response, and this effect was significantly dependent on the stimulus rate. We believe that these modeling results can provide guidance regarding perimodiolar and lateral insertion of CIs in clinical settings and help understand CI performance.

  16. Large-scale computer-generated absorption holograms of 3D objects: II. Practical methodology

    Science.gov (United States)

    Phillips, Nicholas J.; Cameron, Colin D.; Dodd, Adrian K.; Payne, Douglas A.; Sheerin, David T.; Slinger, Christopher W.

    1999-03-01

    As a support to the advances in theoretical understanding and computational methods, we describe a new laser plotter technique that enables, in principle, an unlimited size of pixel array to be plotted efficiently with a rigorous estimate of duration of the plot run time. Developments in laser plotter design are presented that allow the formation of pixellated holographic structures of high precision (c. 1 - 10 micron pixel dia.) with an accompanying high pixel count (e.g. at least up to, and beyond, 104 per side within a square array). The case of absorption holograms offers an easy route to a good quality result. We can then exploit the many tricks of amplitude holography borrowed from lithographic and holographic experience using ultra-fine grain silver halide materials. The problem of exposure quantization and linearization is addressed in a pragmatic fashion. The central issue of why such holograms can tolerate intrinsic diffraction artifacts within each pixel is considered along with the exposure level quantization -- it is difficult to print individual pixels within which the optical density is clinically uniform. We cannot over-estimate the reliability difficulties that can arise in a system designed to print massive arrays of pixels in a serial fashion. The electronic testing involved has to be associated with error-free repeatability and high accompanying switching speeds. This may look easy but it is the major issue that distinguishes serially printed digital holography from the simple one-step parallel process of forming the ordinary hologram.

  17. 3-D computational method of wave loads on turret moored FPSO tankers

    Institute of Scientific and Technical Information of China (English)

    REN Hui-long; ZHANG Hai-bin; DAI Yu-zhi; SONG Jing-zheng

    2003-01-01

    A three-dimensional method of calculating wave loads of turret moored FPSO (Floating Production Storage and Offloading) tankers is presented. The linearized restoring forces acting on the ship hull by the mooring system are calculated according to the catenary theory, which are expressed as the function of linear stiffness coefficients and the displacements of the upper ends of mooring chains. The hydrodynamic coefficients of the ship are calculated by the three-dimensional potential flow theory of the linear hydrodynamic problem for ships with a low forward speed. The equations of ship motions are established with the effect of the restoring forces from the mooring system included as linear stiffness coefficients. The equations of motions are solved in frequency domain, and the responses of wave-induced motions and loads on the ship can be obtained. A computer program based on this method has been developed,and some calculation examples are illustrated. Analysis results show that the method can give satisfying prediction of wave loads.

  18. 3D Reconstruction of Intricate Archean Microbial Structures Using Neutron Computed Tomography and Serial Sectioning

    Science.gov (United States)

    Huerta, N. J.; Murphy, M. A.; Natarajan, V.; Weber, G.; Hamann, B.; Sumner, D. Y.

    2005-12-01

    Three-dimensional visualization of intricate microbial structures in rocks is essential to understand the growth of ancient microbial communities. We have imaged and reconstructed the three-dimensional morphology of 2.5-2.6 billion year old intricate microbialites preserved in carbonate using both serial sectioning and neutron computed tomography (NCT). Reconstruction techniques vary with data type and sample preservation. NCT is a non-destructive technique for imaging organic-containing samples with sufficiently high hydrogen concentrations. The resolution of reconstruction is finer than 500 microns. We reconstructed microbialites preserved as organic inclusions in calcite using NCT. Reconstructions are interpreted using volume rendering, segmentation, and an interactive Matlab/visualization environment. Visualizations demonstrate the intricacy of the structures. Noise currently limits automatic growth surface extraction, but growth of structures can be qualitatively evaluated. One of the largest obstacles to date is efficient manipulation of large data sets. Our current visualization approach always renders the supplied data set at full resolution, which requires down-sampling of datasets larger than 256 pixels3 (acquired volume data consists of up to 2048 pixels3) to isolate regions of interest and extract important features. We are exploring the use of multi-resolution techniques that store a dataset at different levels of detail and chose an appropriate resolution during user-interaction. Such an approach will allow us to visualize raw data at full resolution. Serial sectioning and scanning successive horizons provides reconstructions of samples lacking sufficient hydrogen for NCT. This technique destroys the sample and has a lower resolution than NCT. However, intricate networks of microbial laminae surrounded by cement-filled voids can be characterized using this technique. After microbial surfaces are manually interpreted on slices, the images lack noise

  19. Efficient computational methods for electromagnetic imaging with applications to 3D magnetotellurics

    Science.gov (United States)

    Kordy, Michal Adam

    The motivation for this work is the forward and inverse problem for magnetotellurics, a frequency domain electromagnetic remote-sensing geophysical method used in mineral, geothermal, and groundwater exploration. The dissertation consists of four papers. In the first paper, we prove the existence and uniqueness of a representation of any vector field in H(curl) by a vector lying in H(curl) and H(div). It allows us to represent electric or magnetic fields by another vector field, for which nodal finite element approximation may be used in the case of non-constant electromagnetic properties. With this approach, the system matrix does not become ill-posed for low-frequency. In the second paper, we consider hexahedral finite element approximation of an electric field for the magnetotelluric forward problem. The near-null space of the system matrix for low frequencies makes the numerical solution unstable in the air. We show that the proper solution may obtained by applying a correction on the null space of the curl. It is done by solving a Poisson equation using discrete Helmholtz decomposition. We parallelize the forward code on multicore workstation with large RAM. In the next paper, we use the forward code in the inversion. Regularization of the inversion is done by using the second norm of the logarithm of conductivity. The data space Gauss-Newton approach allows for significant savings in memory and computational time. We show the efficiency of the method by considering a number of synthetic inversions and we apply it to real data collected in Cascade Mountains. The last paper considers a cross-frequency interpolation of the forward response as well as the Jacobian. We consider Pade approximation through model order reduction and rational Krylov subspace. The interpolating frequencies are chosen adaptively in order to minimize the maximum error of interpolation. Two error indicator functions are compared. We prove a theorem of almost always lucky failure in the

  20. 3D periodic multiscale TiO2 architecture: a platform decorated with graphene quantum dots for enhanced photoelectrochemical water splitting

    Science.gov (United States)

    Xu, Zhen; Yin, Min; Sun, Jing; Ding, Guqiao; Lu, Linfeng; Chang, Paichun; Chen, Xiaoyuan; Li, Dongdong

    2016-03-01

    Micropatterned TiO2 nanorods (TiO2NRs) via three-dimensional (3D) geometry engineering in both microscale and nanoscale decorated with graphene quantum dots (GQDs) have been demonstrated successfully. First, micropillar (MP) and microcave (MC) arrays of anatase TiO2 films are obtained through the sol-gel based thermal nanoimprinting method. Then they are employed as seed layers in hydrothermal growth to fabricate the 3D micropillar/microcave arrays of rutile TiO2NRs (NR), which show much-improved photoelectrochemical water-splitting performance than the TiO2NRs grown on flat seed layer. The zero-dimensional GQDs are sequentially deposited onto the surfaces of the microscale patterned nanorods. Owing to the fast charge separation that resulted from the favorable band alignment of the GQDs and rutile TiO2, the MP-NR-GQDs electrode achieves a photocurrent density up to 2.92 mA cm-2 under simulated one-sun illumination. The incident-photon-to-current-conversion efficiency (IPCE) value up to 72% at 370 nm was achieved on the MP-NR-GQDs electrode, which outperforms the flat-NR counterpart by 69%. The IPCE results also imply that the improved photocurrent mainly benefits from the distinctly enhanced ultraviolet response. The work provides a cost-effective and flexible pathway to develop periodic 3D micropatterned photoelectrodes and is promising for the future deployment of high performance optoelectronic devices.

  1. Computational hologram synthesis and representation on spatial light modulators for real-time 3D holographic imaging

    International Nuclear Information System (INIS)

    In dynamic computer-generated holography that utilizes spatial light modulators, both hologram synthesis and hologram representation are essential in terms of fast computation and high reconstruction quality. For hologram synthesis, i.e. the computation step, Fresnel transform based or point-source based raytracing methods can be applied. In the encoding step, the complex wave-field has to be optimally represented by the SLM with its given modulation capability. For proper hologram reconstruction that implies a simultaneous and independent amplitude and phase modulation of the input wave-field by the SLM. In this paper, we discuss full complex hologram representation methods on SLMs by considering inherent SLM parameter such as modulation type and bit depth on their reconstruction performance such as diffraction efficiency and SNR. We review the three implementation schemes of Burckhardt amplitude-only representation, phase-only macro-pixel representation, and two-phase interference representation. Besides the optical performance we address their hardware complexity and required computational load. Finally, we experimentally demonstrate holographic reconstructions of different representation schemes as obtained by functional prototypes utilizing SeeReal's viewing-window holographic display technology. The proposed hardware implementations enable a fast encoding of complex-valued hologram data and thus will pave the way for commercial real-time holographic 3D imaging in the near future.

  2. Petrophysical analysis of limestone rocks by nuclear logging and 3D high-resolution X-ray computed microtomography

    International Nuclear Information System (INIS)

    This study presents the pore-space system analysis of the 2-ITAB-1-RJ well cores, which were drilled in the Sao Jose do Itaborai Basin, in the state of Rio de Janeiro, Brasil. The analysis presented herein has been developed based on two techniques: nuclear logging and 3D high-resolution X-ray computed microtomography. Nuclear logging has been proven to be the technique that provides better quality and more quantitative information about the porosity using radioactive sources. The Density Gamma Probe and the Neutron Sonde used in this work provide qualitative information about bulk density variations and compensated porosity of the geological formation. The samples obtained from the well cores were analyzed by microtomography. The use of this technique in sedimentary rocks allows quantitative evaluation of pore system and generates high-resolution 3D images (∼microns order). The images and data obtained by microtomography were integrated with the response obtained by nuclear logging. The results obtained by these two techniques allow the understanding of the pore-size distribution and connectivity, as well as the porosity values. Both techniques are important and they complement each other.

  3. Development of a three dimensional multiscale computational model of the human epidermis.

    Directory of Open Access Journals (Sweden)

    Salem Adra

    Full Text Available Transforming Growth Factor (TGF-beta1 is a member of the TGF-beta superfamily ligand-receptor network. and plays a crucial role in tissue regeneration. The extensive in vitro and in vivo experimental literature describing its actions nevertheless describe an apparent paradox in that during re-epithelialisation it acts as proliferation inhibitor for keratinocytes. The majority of biological models focus on certain aspects of TGF-beta1 behaviour and no one model provides a comprehensive story of this regulatory factor's action. Accordingly our aim was to develop a computational model to act as a complementary approach to improve our understanding of TGF-beta1. In our previous study, an agent-based model of keratinocyte colony formation in 2D culture was developed. In this study this model was extensively developed into a three dimensional multiscale model of the human epidermis which is comprised of three interacting and integrated layers: (1 an agent-based model which captures the biological rules governing the cells in the human epidermis at the cellular level and includes the rules for injury induced emergent behaviours, (2 a COmplex PAthway SImulator (COPASI model which simulates the expression and signalling of TGF-beta1 at the sub-cellular level and (3 a mechanical layer embodied by a numerical physical solver responsible for resolving the forces exerted between cells at the multi-cellular level. The integrated model was initially validated by using it to grow a piece of virtual epidermis in 3D and comparing the in virtuo simulations of keratinocyte behaviour and of TGF-beta1 signalling with the extensive research literature describing this key regulatory protein. This research reinforces the idea that computational modelling can be an effective additional tool to aid our understanding of complex systems. In the accompanying paper the model is used to explore hypotheses of the functions of TGF-beta1 at the cellular and subcellular level on

  4. Steady-State VEP-Based Brain-Computer Interface Control in an Immersive 3D Gaming Environment

    Directory of Open Access Journals (Sweden)

    Burke R

    2005-01-01

    Full Text Available This paper presents the application of an effective EEG-based brain-computer interface design for binary control in a visually elaborate immersive 3D game. The BCI uses the steady-state visual evoked potential (SSVEP generated in response to phase-reversing checkerboard patterns. Two power-spectrum estimation methods were employed for feature extraction in a series of offline classification tests. Both methods were also implemented during real-time game play. The performance of the BCI was found to be robust to distracting visual stimulation in the game and relatively consistent across six subjects, with 41 of 48 games successfully completed. For the best performing feature extraction method, the average real-time control accuracy across subjects was 89%. The feasibility of obtaining reliable control in such a visually rich environment using SSVEPs is thus demonstrated and the impact of this result is discussed.

  5. The DANTE Boltzmann transport solver: An unstructured mesh, 3-D, spherical harmonics algorithm compatible with parallel computer architectures

    International Nuclear Information System (INIS)

    A spherical harmonics research code (DANTE) has been developed which is compatible with parallel computer architectures. DANTE provides 3-D, multi-material, deterministic, transport capabilities using an arbitrary finite element mesh. The linearized Boltzmann transport equation is solved in a second order self-adjoint form utilizing a Galerkin finite element spatial differencing scheme. The core solver utilizes a preconditioned conjugate gradient algorithm. Other distinguishing features of the code include options for discrete-ordinates and simplified spherical harmonics angular differencing, an exact Marshak boundary treatment for arbitrarily oriented boundary faces, in-line matrix construction techniques to minimize memory consumption, and an effective diffusion based preconditioner for scattering dominated problems. Algorithm efficiency is demonstrated for a massively parallel SIMD architecture (CM-5), and compatibility with MPP multiprocessor platforms or workstation clusters is anticipated

  6. Mechanical integrity of a carbon nanotube/copper-based through-silicon via for 3D integrated circuits: a multi-scale modeling approach.

    Science.gov (United States)

    Awad, Ibrahim; Ladani, Leila

    2015-12-01

    Carbon nanotube (CNT)/copper (Cu) composite material is proposed to replace Cu-based through-silicon vias (TSVs) in micro-electronic packages. The proposed material is believed to offer extraordinary mechanical and electrical properties and the presence of CNTs in Cu is believed to overcome issues associated with miniaturization of Cu interconnects, such as electromigration. This study introduces a multi-scale modeling of the proposed TSV in order to evaluate its mechanical integrity under mechanical and thermo-mechanical loading conditions. Molecular dynamics (MD) simulation was used to determine CNT/Cu interface adhesion properties. A cohesive zone model (CZM) was found to be most appropriate to model the interface adhesion, and CZM parameters at the nanoscale were determined using MD simulation. CZM parameters were then used in the finite element analysis in order to understand the mechanical and thermo-mechanical behavior of composite TSV at micro-scale. From the results, CNT/Cu separation does not take place prior to plastic deformation of Cu in bending, and separation does not take place when standard thermal cycling is applied. Further investigation is recommended in order to alleviate the increased plastic deformation in Cu at the CNT/Cu interface in both loading conditions. PMID:26559788

  7. MULTI-SCALE FE COMPUTATION FOR THE STRUCTURES OF COMPOSITE MATERIALS WITH SMALL PERIODIC CONFIGURATION UNDER CONDITION OF COUPLED THERMOELASTICITY

    Institute of Scientific and Technical Information of China (English)

    FENG Yongping; CUI Junzhi

    2004-01-01

    In this paper, the multi-scale computational method for a structure of composite materials with a small periodic configuration under the coupled thermoelasticity condition is presented.The two-scale asymptotic (TSA) expression of the displacement and the increment of temperature for composite materials with a small periodic configuration under the condition of thermoelasticity are briefly shown at first, then the multi-scale finite element algorithms based on TSA are discussed. Finally the numerical results evaluated by the multi-scale computational method are shown. It demonstrates that the basic configuration and the increment of temperature strongly influence the local strains and local stresses inside a basic cell.

  8. Voxelization algorithms for geospatial applications: Computational methods for voxelating spatial datasets of 3D city models containing 3D surface, curve and point data models.

    Science.gov (United States)

    Nourian, Pirouz; Gonçalves, Romulo; Zlatanova, Sisi; Ohori, Ken Arroyo; Vu Vo, Anh

    2016-01-01

    Voxel representations have been used for years in scientific computation and medical imaging. The main focus of our research is to provide easy access to methods for making large-scale voxel models of built environment for environmental modelling studies while ensuring they are spatially correct, meaning they correctly represent topological and semantic relations among objects. In this article, we present algorithms that generate voxels (volumetric pixels) out of point cloud, curve, or surface objects. The algorithms for voxelization of surfaces and curves are a customization of the topological voxelization approach [1]; we additionally provide an extension of this method for voxelization of point clouds. The developed software has the following advantages:•It provides easy management of connectivity levels in the resulting voxels.•It is not dependant on any external library except for primitive types and constructs; therefore, it is easy to integrate them in any application.•One of the algorithms is implemented in C++ and C for platform independence and efficiency.

  9. Voxelization algorithms for geospatial applications: Computational methods for voxelating spatial datasets of 3D city models containing 3D surface, curve and point data models.

    Science.gov (United States)

    Nourian, Pirouz; Gonçalves, Romulo; Zlatanova, Sisi; Ohori, Ken Arroyo; Vu Vo, Anh

    2016-01-01

    Voxel representations have been used for years in scientific computation and medical imaging. The main focus of our research is to provide easy access to methods for making large-scale voxel models of built environment for environmental modelling studies while ensuring they are spatially correct, meaning they correctly represent topological and semantic relations among objects. In this article, we present algorithms that generate voxels (volumetric pixels) out of point cloud, curve, or surface objects. The algorithms for voxelization of surfaces and curves are a customization of the topological voxelization approach [1]; we additionally provide an extension of this method for voxelization of point clouds. The developed software has the following advantages:•It provides easy management of connectivity levels in the resulting voxels.•It is not dependant on any external library except for primitive types and constructs; therefore, it is easy to integrate them in any application.•One of the algorithms is implemented in C++ and C for platform independence and efficiency. PMID:27408832

  10. Modified multiscale sample entropy computation of laser speckle contrast images and comparison with the original multiscale entropy algorithm.

    Science.gov (United States)

    Humeau-Heurtier, Anne; Mahé, Guillaume; Abraham, Pierre

    2015-12-01

    Laser speckle contrast imaging (LSCI) enables a noninvasive monitoring of microvascular perfusion. Some studies have proposed to extract information from LSCI data through their multiscale entropy (MSE). However, for reaching a large range of scales, the original MSE algorithm may require long recordings for reliability. Recently, a novel approach to compute MSE with shorter data sets has been proposed: the short-time MSE (sMSE). Our goal is to apply, for the first time, the sMSE algorithm in LSCI data and to compare results with those given by the original MSE. Moreover, we apply the original MSE algorithm on data of different lengths and compare results with those given by longer recordings. For this purpose, synthetic signals and 192 LSCI regions of interest (ROIs) of different sizes are processed. Our results show that the sMSE algorithm is valid to compute the MSE of LSCI data. Moreover, with time series shorter than those initially proposed, the sMSE and original MSE algorithms give results with no statistical difference from those of the original MSE algorithm with longer data sets. The minimal acceptable length depends on the ROI size. Comparisons of MSE from healthy and pathological subjects can be performed with shorter data sets than those proposed until now. PMID:26220209

  11. A relocalization technique for the multiscale computation of delamination in composite structures

    CERN Document Server

    Allix, Olivier; Gosselet, Pierre

    2011-01-01

    In this article, we present numerical enhancements of a multiscale domain decomposition strategy based on a LaTIn solver and dedicated to the computation of the debounding in laminates. We show that the classical scale separation is irrelevant in the process zones, which results in a drop in the convergence rate of the strategy. The scalability is restored by performing nonlinear subresolutions in the vincinity of the front of the crack, at each prediction stage of the iterative solver.

  12. Exact Computation of the Topology and Geometric Invariants of the Voronòi Diagram of Spheres in 3D

    Institute of Scientific and Technical Information of China (English)

    Fran(c)ois Anton; Darka Mioc; Marcelo Santos

    2013-01-01

    In this paper,we are addressing the exact computation of the Delaunay graph (or quasi-triangulation) and the Voronoi diagram of spheres using Wu's algorithm.Our main contributions are first a methodology for automated derivation of invariants of the Delaunay empty circumsphere predicate for spheres and the Voronoi vertex of four spheres,then the application of this methodology to get all geometrical invariants that intervene in this problem and the exact computation of the Delaunay graph and the Voronoi diagram of spheres.To the best of our knowledge,there does not exist a comprehensive treatment of the exact computation with geometrical invariants of the Delaunay graph and the Voronoi diagram of spheres.Starting from the system of equations defining the zero-dimensional algebraic set of the problem,we are applying Wu's algorithm to transform the initial system into an equivalent Wu characteristic (triangular) set.In the corresponding system of algebraic equations,in each polynomial (except the first one),the variable with higher order from the preceding polynomial has been eliminated (by pseudo-remainder computations) and the last polynomial we obtain is a polynomial of a single variable.By regrouping all the formal coefficients for each monomial in each polynomial,we get polynomials that are invariants for the given problem.We rewrite the original system by replacing the invariant polynomials by new formal coefficients.We repeat the process until all the algebraic relationships (syzygies) between the invariants have been found by applying Wu's algorithm on the invariants.Finally,we present an incremental algorithm for the construction of Voronoi diagrams and Delaunay graphs of spheres in 3D and its application to Geodesy.

  13. Modeling warm dense matter experiments using the 3D ALE-AMR code and the move toward exascale computing

    Directory of Open Access Journals (Sweden)

    Koniges Alice

    2013-11-01

    Full Text Available The Neutralized Drift Compression Experiment II (NDCX II is an induction accelerator planned for initial commissioning in 2012. The final design calls for a 3 MeV, Li+ ion beam, delivered in a bunch with characteristic pulse duration of 1 ns, and transverse dimension of order 1 mm. The NDCX II will be used in studies of material in the warm dense matter (WDM regime, and ion beam/hydrodynamic coupling experiments relevant to heavy ion based inertial fusion energy. We discuss recent efforts to adapt the 3D ALE-AMR code to model WDM experiments on NDCX II. The code, which combines Arbitrary Lagrangian Eulerian (ALE hydrodynamics with Adaptive Mesh Refinement (AMR, has physics models that include ion deposition, radiation hydrodynamics, thermal diffusion, anisotropic material strength with material time history, and advanced models for fragmentation. Experiments at NDCX-II will explore the process of bubble and droplet formation (two-phase expansion of superheated metal solids using ion beams. Experiments at higher temperatures will explore equation of state and heavy ion fusion beam-to-target energy coupling efficiency. Ion beams allow precise control of local beam energy deposition providing uniform volumetric heating on a timescale shorter than that of hydrodynamic expansion. We also briefly discuss the effects of the move to exascale computing and related computational changes on general modeling codes in fusion.

  14. Study of Propagation Mechanisms in Dynamical Railway Environment to Reduce Computation Time of 3D Ray Tracing Simulator

    Directory of Open Access Journals (Sweden)

    Siham Hairoud

    2013-01-01

    Full Text Available In order to better assess the behaviours of the propagation channel in a confined environment such as a railway tunnel for subway application, we present an optimization method for a deterministic channel simulator based on 3D ray tracing associated to the geometrical optics laws and the uniform theory of diffraction. This tool requires a detailed description of the environment. Thus, the complexity of this model is directly bound to the complexity of the environment and specifically to the number of facets that compose it. In this paper, we propose an algorithm to identify facets that have no significant impact on the wave propagation. This allows us to simplify the description of the geometry of the modelled environment by removing them and by this way, to reduce the complexity of our model and therefore its computation time. A comparative study between full and simplified environment is led and shows the impact of this proposed method on the characteristic parameters of the propagation channel. Thus computation time obtained from the simplified environment is 6 times lower than the one of the full model without significant degradation of simulation accuracy.

  15. Demonstration of a Novel, Integrated, Multi-Scale Procedure for High-Resolution 3D Reservoir Characterization and Improved CO2-EOR/Sequestration Management, SACROC Unit

    Energy Technology Data Exchange (ETDEWEB)

    Scott R. Reeves

    2007-09-30

    The primary goal of this project was to demonstrate a new and novel approach for high resolution, 3D reservoir characterization that can enable better management of CO{sub 2} enhanced oil recovery (EOR) projects and, looking to the future, carbon sequestration projects. The approach adopted has been the subject of previous research by the DOE and others, and relies primarily upon data-mining and advanced pattern recognition approaches. This approach honors all reservoir characterization data collected, but accepts that our understanding of how these measurements relate to the information of most interest, such as how porosity and permeability vary over a reservoir volume, is imperfect. Ideally the data needed for such an approach includes surface seismic to provide the greatest amount of data over the entire reservoir volume of interest, crosswell seismic to fill the resolution gap between surface seismic and wellbore-scale measurements, geophysical well logs to provide the vertical resolution sought, and core data to provide the tie to the information of most interest. These data are combined via a series of one or more relational models to enable, in its most successful application, the prediction of porosity and permeability on a vertical resolution similar to logs at each surface seismic trace location. In this project, the procedure was applied to the giant (and highly complex) SACROC unit of the Permian basin in West Texas, one of the world's largest CO{sub 2}-EOR projects and a potentially world-class geologic sequestration site. Due to operational scheduling considerations on the part of the operator of the field, the crosswell data was not obtained during the period of project performance (it is currently being collected however as part of another DOE project). This compromised the utility of the surface seismic data for the project due to the resolution gap between it and the geophysical well logs. An alternative approach was adopted that utilized a

  16. 3-D Reconstruction of Medical Image Using Wavelet Transform and Snake Model

    Directory of Open Access Journals (Sweden)

    Jinyong Cheng

    2009-12-01

    Full Text Available Medical image segmentation is an important step in 3-D reconstruction, and 3-D reconstruction from medical images is an important application of computer graphics and biomedicine image processing. An improved image segmentation method which is suitable for 3-D reconstruction is presented in this paper. A 3-D reconstruction algorithm is used to reconstruct the 3-D model from medical images. Rough edge is obtained by multi-scale wavelet transform at first. With the rough edge, improved gradient vector flow snake model is used and the object contour in the image is found. In the experiments, we reconstruct 3-D models of kidney, liver and brain putamen. The performances of the experiments indicate that the new algorithm can produce accurate 3-D reconstruction.

  17. The Intercomparison of 3D Radiation Codes (I3RC): Showcasing Mathematical and Computational Physics in a Critical Atmospheric Application

    Science.gov (United States)

    Davis, A. B.; Cahalan, R. F.

    2001-05-01

    The Intercomparison of 3D Radiation Codes (I3RC) is an on-going initiative involving an international group of over 30 researchers engaged in the numerical modeling of three-dimensional radiative transfer as applied to clouds. Because of their strong variability and extreme opacity, clouds are indeed a major source of uncertainty in the Earth's local radiation budget (at GCM grid scales). Also 3D effects (at satellite pixel scales) invalidate the standard plane-parallel assumption made in the routine of cloud-property remote sensing at NASA and NOAA. Accordingly, the test-cases used in I3RC are based on inputs and outputs which relate to cloud effects in atmospheric heating rates and in real-world remote sensing geometries. The main objectives of I3RC are to (1) enable participants to improve their models, (2) publish results as a community, (3) archive source code, and (4) educate. We will survey the status of I3RC and its plans for the near future with a special emphasis on the mathematical models and computational approaches. We will also describe some of the prime applications of I3RC's efforts in climate models, cloud-resolving models, and remote-sensing observations of clouds, or that of the surface in their presence. In all these application areas, computational efficiency is the main concern and not accuracy. One of I3RC's main goals is to document the performance of as wide a variety as possible of three-dimensional radiative transfer models for a small but representative number of ``cases.'' However, it is dominated by modelers working at the level of linear transport theory (i.e., they solve the radiative transfer equation) and an overwhelming majority of these participants use slow-but-robust Monte Carlo techniques. This means that only a small portion of the efficiency vs. accuracy vs. flexibility domain is currently populated by I3RC participants. To balance this natural clustering the present authors have organized a systematic outreach towards

  18. Modification of a Colliculo-thalamocortical Mouse Brain Slice, Incorporating 3-D printing of Chamber Components and Multi-scale Optical Imaging.

    Science.gov (United States)

    Slater, Bernard J; Fan, Anthony Y; Stebbings, Kevin A; Saif, M Taher A; Llano, Daniel A

    2015-01-01

    The ability of the brain to process sensory information relies on both ascending and descending sets of projections. Until recently, the only way to study these two systems and how they interact has been with the use of in vivo preparations. Major advances have been made with acute brain slices containing the thalamocortical and cortico-thalamic pathways in the somatosensory, visual, and auditory systems. With key refinements to our recent modification of the auditory thalamocortical slice(1), we are able to more reliably capture the projections between most of the major auditory midbrain and forebrain structures: the inferior colliculus (IC), medial geniculate body (MGB), thalamic reticular nucleus (TRN), and the auditory cortex (AC). With portions of all these connections retained, we are able to answer detailed questions that complement the questions that can be answered with in vivo preparations. The use of flavoprotein autofluorescence imaging enables us to rapidly assess connectivity in any given slice and guide the ensuing experiment. Using this slice in conjunction with recording and imaging techniques, we are now better equipped to understand how information processing occurs at each point in the auditory forebrain as information ascends to the cortex, and the impact of descending cortical modulation. 3-D printing to build slice chamber components permits double-sided perfusion and broad access to networks within the slice and maintains the widespread connections key to fully utilizing this preparation. PMID:26437382

  19. Enhanced methods for computing spectra from CO5BOLD models using Linfor3D. Molecular bands in metal-poor stars

    CERN Document Server

    Gallagher, A J; Caffau, E; Bonifacio, P; Ludwig, H -G; Freytag, B

    2016-01-01

    Molecular features such as the G-band, CN-band and NH-band are important diagnostics for measuring a star's carbon and nitrogen abundances, especially in metal-poor stars where atomic lines are no longer visible in stellar spectra. Unlike atomic transitions, molecular features tend to form in bands, which cover large wavelength regions in a spectrum. While it is a trivial matter to compute carbon and nitrogen molecular bands under the assumption of 1D, it is extremely time consuming in 3D. In this contribution to the 2016 CO5BOLD workshop we review the improvements made to the 3D spectral synthesis code Linfor3D, and discuss the new challenges found when computing molecular features in 3D.

  20. Multi-level 3D non-LTE computations of lithium lines in the metal-poor halo stars HD140283 and HD84937

    OpenAIRE

    Asplund, M.; Carlsson, M; Botnen, A

    2003-01-01

    The lithium abundances in metal-poor halo stars are of importance for cosmology, galaxy evolution and stellar structure. In an attempt to study possible systematic errors in the derived Li abundances, the line formation of LiI lines has been investigated by means of realistic 3D hydrodynamical model atmospheres of halo stars and 3D non-LTE radiative transfer calculations. These are the first detailed 3D non-LTE computations reported employing a multi-level atomic model showing that such probl...

  1. A Real-Time Magnetoencephalography Brain-Computer Interface Using Interactive 3D Visualization and the Hadoop Ecosystem

    Science.gov (United States)

    McClay, Wilbert A.; Yadav, Nancy; Ozbek, Yusuf; Haas, Andy; Attias, Hagaii T.; Nagarajan, Srikantan S.

    2015-01-01

    Ecumenically, the fastest growing segment of Big Data is human biology-related data and the annual data creation is on the order of zetabytes. The implications are global across industries, of which the treatment of brain related illnesses and trauma could see the most significant and immediate effects. The next generation of health care IT and sensory devices are acquiring and storing massive amounts of patient related data. An innovative Brain-Computer Interface (BCI) for interactive 3D visualization is presented utilizing the Hadoop Ecosystem for data analysis and storage. The BCI is an implementation of Bayesian factor analysis algorithms that can distinguish distinct thought actions using magneto encephalographic (MEG) brain signals. We have collected data on five subjects yielding 90% positive performance in MEG mid- and post-movement activity. We describe a driver that substitutes the actions of the BCI as mouse button presses for real-time use in visual simulations. This process has been added into a flight visualization demonstration. By thinking left or right, the user experiences the aircraft turning in the chosen direction. The driver components of the BCI can be compiled into any software and substitute a user’s intent for specific keyboard strikes or mouse button presses. The BCI’s data analytics of a subject’s MEG brainwaves and flight visualization performance are stored and analyzed using the Hadoop Ecosystem as a quick retrieval data warehouse. PMID:26437432

  2. A Real-Time Magnetoencephalography Brain-Computer Interface Using Interactive 3D Visualization and the Hadoop Ecosystem.

    Science.gov (United States)

    McClay, Wilbert A; Yadav, Nancy; Ozbek, Yusuf; Haas, Andy; Attias, Hagaii T; Nagarajan, Srikantan S

    2015-01-01

    Ecumenically, the fastest growing segment of Big Data is human biology-related data and the annual data creation is on the order of zetabytes. The implications are global across industries, of which the treatment of brain related illnesses and trauma could see the most significant and immediate effects. The next generation of health care IT and sensory devices are acquiring and storing massive amounts of patient related data. An innovative Brain-Computer Interface (BCI) for interactive 3D visualization is presented utilizing the Hadoop Ecosystem for data analysis and storage. The BCI is an implementation of Bayesian factor analysis algorithms that can distinguish distinct thought actions using magneto encephalographic (MEG) brain signals. We have collected data on five subjects yielding 90% positive performance in MEG mid- and post-movement activity. We describe a driver that substitutes the actions of the BCI as mouse button presses for real-time use in visual simulations. This process has been added into a flight visualization demonstration. By thinking left or right, the user experiences the aircraft turning in the chosen direction. The driver components of the BCI can be compiled into any software and substitute a user's intent for specific keyboard strikes or mouse button presses. The BCI's data analytics OPEN ACCESS Brain. Sci. 2015, 5 420 of a subject's MEG brainwaves and flight visualization performance are stored and analyzed using the Hadoop Ecosystem as a quick retrieval data warehouse. PMID:26437432

  3. Rational Design of Prevascularized Large 3D Tissue Constructs Using Computational Simulations and Biofabrication of Geometrically Controlled Microvessels.

    Science.gov (United States)

    Arrigoni, Chiara; Bongio, Matilde; Talò, Giuseppe; Bersini, Simone; Enomoto, Junko; Fukuda, Junji; Moretti, Matteo

    2016-07-01

    A major challenge in the development of clinically relevant 3D tissue constructs is the formation of vascular networks for oxygenation, nutrient supply, and waste removal. To this end, this study implements a multimodal approach for the promotion of vessel-like structures formation in stiff fibrin hydrogels. Computational simulations have been performed to identify the easiest microchanneled configuration assuring normoxic conditions throughout thick cylindrical hydrogels (8 mm height, 6 mm ∅), showing that in our configuration a minimum of three microchannels (600 μm ∅), placed in a non-planar disposition, is required. Using small hydrogel bricks with oxygen distribution equal to the microchanneled configuration, this study demonstrates that among different culture conditions, co-culture of mesenchymal and endothelial cells supplemented with ANG-1 and VEGF leads to the most developed vascular network. Microchanneled hydrogels have been then cultured in the same conditions both statically and in a bioreactor for 7 d. Unexpectedly, the combination between shear forces and normoxic conditions is unable to promote microvascular networks formation in three-channeled hydrogels. Differently, application of either shear forces or normoxic conditions alone results in microvessels outgrowth. These results suggest that to induce angiogenesis in engineered constructs, complex interactions between several biochemical and biophysical parameters have to be modulated.

  4. Rational Design of Prevascularized Large 3D Tissue Constructs Using Computational Simulations and Biofabrication of Geometrically Controlled Microvessels.

    Science.gov (United States)

    Arrigoni, Chiara; Bongio, Matilde; Talò, Giuseppe; Bersini, Simone; Enomoto, Junko; Fukuda, Junji; Moretti, Matteo

    2016-07-01

    A major challenge in the development of clinically relevant 3D tissue constructs is the formation of vascular networks for oxygenation, nutrient supply, and waste removal. To this end, this study implements a multimodal approach for the promotion of vessel-like structures formation in stiff fibrin hydrogels. Computational simulations have been performed to identify the easiest microchanneled configuration assuring normoxic conditions throughout thick cylindrical hydrogels (8 mm height, 6 mm ∅), showing that in our configuration a minimum of three microchannels (600 μm ∅), placed in a non-planar disposition, is required. Using small hydrogel bricks with oxygen distribution equal to the microchanneled configuration, this study demonstrates that among different culture conditions, co-culture of mesenchymal and endothelial cells supplemented with ANG-1 and VEGF leads to the most developed vascular network. Microchanneled hydrogels have been then cultured in the same conditions both statically and in a bioreactor for 7 d. Unexpectedly, the combination between shear forces and normoxic conditions is unable to promote microvascular networks formation in three-channeled hydrogels. Differently, application of either shear forces or normoxic conditions alone results in microvessels outgrowth. These results suggest that to induce angiogenesis in engineered constructs, complex interactions between several biochemical and biophysical parameters have to be modulated. PMID:27191352

  5. A Real-Time Magnetoencephalography Brain-Computer Interface Using Interactive 3D Visualization and the Hadoop Ecosystem

    Directory of Open Access Journals (Sweden)

    Wilbert A. McClay

    2015-09-01

    Full Text Available Ecumenically, the fastest growing segment of Big Data is human biology-related data and the annual data creation is on the order of zetabytes. The implications are global across industries, of which the treatment of brain related illnesses and trauma could see the most significant and immediate effects. The next generation of health care IT and sensory devices are acquiring and storing massive amounts of patient related data. An innovative Brain-Computer Interface (BCI for interactive 3D visualization is presented utilizing the Hadoop Ecosystem for data analysis and storage. The BCI is an implementation of Bayesian factor analysis algorithms that can distinguish distinct thought actions using magneto encephalographic (MEG brain signals. We have collected data on five subjects yielding 90% positive performance in MEG mid- and post-movement activity. We describe a driver that substitutes the actions of the BCI as mouse button presses for real-time use in visual simulations. This process has been added into a flight visualization demonstration. By thinking left or right, the user experiences the aircraft turning in the chosen direction. The driver components of the BCI can be compiled into any software and substitute a user’s intent for specific keyboard strikes or mouse button presses. The BCI’s data analytics OPEN ACCESS Brain. Sci. 2015, 5 420 of a subject’s MEG brainwaves and flight visualization performance are stored and analyzed using the Hadoop Ecosystem as a quick retrieval data warehouse.

  6. A Real-Time Magnetoencephalography Brain-Computer Interface Using Interactive 3D Visualization and the Hadoop Ecosystem.

    Science.gov (United States)

    McClay, Wilbert A; Yadav, Nancy; Ozbek, Yusuf; Haas, Andy; Attias, Hagaii T; Nagarajan, Srikantan S

    2015-09-30

    Ecumenically, the fastest growing segment of Big Data is human biology-related data and the annual data creation is on the order of zetabytes. The implications are global across industries, of which the treatment of brain related illnesses and trauma could see the most significant and immediate effects. The next generation of health care IT and sensory devices are acquiring and storing massive amounts of patient related data. An innovative Brain-Computer Interface (BCI) for interactive 3D visualization is presented utilizing the Hadoop Ecosystem for data analysis and storage. The BCI is an implementation of Bayesian factor analysis algorithms that can distinguish distinct thought actions using magneto encephalographic (MEG) brain signals. We have collected data on five subjects yielding 90% positive performance in MEG mid- and post-movement activity. We describe a driver that substitutes the actions of the BCI as mouse button presses for real-time use in visual simulations. This process has been added into a flight visualization demonstration. By thinking left or right, the user experiences the aircraft turning in the chosen direction. The driver components of the BCI can be compiled into any software and substitute a user's intent for specific keyboard strikes or mouse button presses. The BCI's data analytics OPEN ACCESS Brain. Sci. 2015, 5 420 of a subject's MEG brainwaves and flight visualization performance are stored and analyzed using the Hadoop Ecosystem as a quick retrieval data warehouse.

  7. Rapid Reconstitution Packages (RRPs) implemented by integration of computational fluid dynamics (CFD) and 3D printed microfluidics.

    Science.gov (United States)

    Chi, Albert; Curi, Sebastian; Clayton, Kevin; Luciano, David; Klauber, Kameron; Alexander-Katz, Alfredo; D'hers, Sebastian; Elman, Noel M

    2014-08-01

    Rapid Reconstitution Packages (RRPs) are portable platforms that integrate microfluidics for rapid reconstitution of lyophilized drugs. Rapid reconstitution of lyophilized drugs using standard vials and syringes is an error-prone process. RRPs were designed using computational fluid dynamics (CFD) techniques to optimize fluidic structures for rapid mixing and integrating physical properties of targeted drugs and diluents. Devices were manufactured using stereo lithography 3D printing for micrometer structural precision and rapid prototyping. Tissue plasminogen activator (tPA) was selected as the initial model drug to test the RRPs as it is unstable in solution. tPA is a thrombolytic drug, stored in lyophilized form, required in emergency settings for which rapid reconstitution is of critical importance. RRP performance and drug stability were evaluated by high-performance liquid chromatography (HPLC) to characterize release kinetics. In addition, enzyme-linked immunosorbent assays (ELISAs) were performed to test for drug activity after the RRPs were exposed to various controlled temperature conditions. Experimental results showed that RRPs provided effective reconstitution of tPA that strongly correlated with CFD results. Simulation and experimental results show that release kinetics can be adjusted by tuning the device structural dimensions and diluent drug physical parameters. The design of RRPs can be tailored for a number of applications by taking into account physical parameters of the active pharmaceutical ingredients (APIs), excipients, and diluents. RRPs are portable platforms that can be utilized for reconstitution of emergency drugs in time-critical therapies.

  8. The 3D MHD code GOEMHD3 for astrophysical plasmas with large Reynolds numbers. Code description, verification, and computational performance

    Science.gov (United States)

    Skála, J.; Baruffa, F.; Büchner, J.; Rampp, M.

    2015-08-01

    Context. The numerical simulation of turbulence and flows in almost ideal astrophysical plasmas with large Reynolds numbers motivates the implementation of magnetohydrodynamical (MHD) computer codes with low resistivity. They need to be computationally efficient and scale well with large numbers of CPU cores, allow obtaining a high grid resolution over large simulation domains, and be easily and modularly extensible, for instance, to new initial and boundary conditions. Aims: Our aims are the implementation, optimization, and verification of a computationally efficient, highly scalable, and easily extensible low-dissipative MHD simulation code for the numerical investigation of the dynamics of astrophysical plasmas with large Reynolds numbers in three dimensions (3D). Methods: The new GOEMHD3 code discretizes the ideal part of the MHD equations using a fast and efficient leap-frog scheme that is second-order accurate in space and time and whose initial and boundary conditions can easily be modified. For the investigation of diffusive and dissipative processes the corresponding terms are discretized by a DuFort-Frankel scheme. To always fulfill the Courant-Friedrichs-Lewy stability criterion, the time step of the code is adapted dynamically. Numerically induced local oscillations are suppressed by explicit, externally controlled diffusion terms. Non-equidistant grids are implemented, which enhance the spatial resolution, where needed. GOEMHD3 is parallelized based on the hybrid MPI-OpenMP programing paradigm, adopting a standard two-dimensional domain-decomposition approach. Results: The ideal part of the equation solver is verified by performing numerical tests of the evolution of the well-understood Kelvin-Helmholtz instability and of Orszag-Tang vortices. The accuracy of solving the (resistive) induction equation is tested by simulating the decay of a cylindrical current column. Furthermore, we show that the computational performance of the code scales very

  9. 3D computed tomographic evaluation of the upper airway space of patients undergoing mandibular distraction osteogenesis for micrognathia.

    Science.gov (United States)

    Bianchi, A; Betti, E; Badiali, G; Ricotta, F; Marchetti, C; Tarsitano, A

    2015-10-01

    Mandibular distraction osteogenesis (MDO) is currently an accepted method of treatment for patients requiring reconstruction of hypoplastic mandibles. To date one of the unsolved problems is how to assess the quantitative increase of mandible length needed to achieve a significant change in the volume of the posterior airway space (PAS) in children with mandibular micrognathia following distraction osteogenesis. The purpose of this study is to present quantitative volumetric evaluation of PAS in young patients having distraction osteogenesis for micrognathia using 3D-CT data sets and compare it with pre-operative situation. In this observational retrospective study, we report our experience in five consecutive patients who underwent MDO in an attempt to relieve severe upper airway obstruction. Each patient was evaluated before treatment (T0) and at the end of distraction procedure (T1) with computer tomography (CT) in axial, coronal, and sagittal planes and three-dimensional CT of the facial bones and upper airway. Using parameters to extract only data within anatomic constraints, a digital set of the edited upper airway volume was obtained. The volume determination was used for volumetric qualification of upper airway. The computed tomographic digital data were used to evaluate the upper airway volumes both pre-distraction and post-distraction. The mean length of distraction was 23 mm. Quantitative assessment of upper airway volume before and after distraction demonstrated increased volumes ranging from 84% to 3,087% with a mean of 536%. In conclusion, our study seems to show that DO can significantly increase the volume of the PAS in patients with upper airway obstruction following micrognathia, by an average of 5 times. Furthermore, the worse is the starting volume, the greater the increase in PAS to equal distraction.

  10. Coronary computed tomography angiography with 320-row detector and using the AIDR-3D: initial experience; Angiotomografia computadorizada de coronarias com tomografo com 320 fileiras de detectores e utilizando o AIDR-3D: experiencia inicial

    Energy Technology Data Exchange (ETDEWEB)

    Sasdelli Neto, Roberto; Nomura, Cesar Higa; Macedo, Ana Carolina Sandoval; Bianco, Danilo Perussi; Kay, Fernando Uliana; Szarf, Gilberto; Teles, Gustavo Borges da Silva; Shoji, Hamilton; Santana Netto, Pedro Vieira; Passos, Rodrigo Bastos Duarte; Chate, Rodrigo Caruso; Ishikawa, Walther Yoshiharu; Lima, Joao Paulo Bacellar Costa; Rocha, Marcelo Assis; Marcos, Vinicius Neves; Funari, Marcelo Buarque de Gusmao, E-mail: roberto.neto@einstein.br [Hospital Israelita Albert Einstein, Sao Paulo, SP (Brazil); Failla, Bruna Bonaventura [Universidade Metodista de Sao Paulo, Sao Bernardo do Campo, SP (Brazil)

    2013-07-01

    Coronary computed tomography angiography (coronary CTA) is a powerful non-invasive imaging method to evaluate coronary artery disease. Nowadays, coronary CTA estimated effective radiation dose can be dramatically reduced using state-of-the-art scanners, such as 320-row detector CT (320-CT), without changing coronary CTA diagnostic accuracy. To optimize and further reduce the radiation dose, new iterative reconstruction algorithms were released recently by several CT manufacturers, and now they are used routinely in coronary CTA. This paper presents our first experience using coronary CTA with 320-CT and the Adaptive Iterative Dose Reduction 3D (AIDR-3D). In addition, we describe the current indications for coronary CTA in our practice as well as the acquisition standard protocols and protocols related to CT application for radiation dose reduction. In conclusion, coronary CTA radiation dose can be dramatically reduced following the 'as low as reasonable achievable' principle by combination of exam indication and well-documented technics for radiation dose reduction, such as beta blockers, low-kV, and also the newest iterative dose reduction software as AIDR-3D. (author)

  11. Examining the effect of pore size distribution and shape on flow through unsaturated peat using 3-D computed tomography

    Directory of Open Access Journals (Sweden)

    F. Rezanezhad

    2009-05-01

    Full Text Available The hydraulic conductivity of unsaturated peat soils is controlled by the peat structure which affects the air-filled porosity, pore size distribution and shape. This study investigates how the size and shape of pores affects the flow of water through peat soils. In this study we used X-ray Computed Tomography (CT, at 45 µm resolution under 5 specific soil-water pressure head levels to provide 3-D, high-resolution images that were used to detect the inner pore structure of peat samples under a changing water regime. Pore structure and configuration were found to be irregular, which affected the rate of water transmission through peat soils. The 3-D analysis suggested that pore distribution is dominated by a single large pore-space. At low pressure head, this single large air-filled pore imparted a more effective flowpath compared to smaller pores. Smaller pores were disconnected and the flowpath was more tortuous than in the single large air-filled pore, and their contribution to flow was negligible when the single large pore was active. We quantify the pore structure of peat soil that affects the hydraulic conductivity in the unsaturated condition, and demonstrate the validity of our estimation of peat unsaturated hydraulic conductivity by making a comparison with a standard permeameter-based method. Estimates of unsaturated hydraulic conductivities were made for the purpose of testing the sensitivity of pore shape and geometry parameters on the hydraulic properties of peats and how to evaluate the structure of the peat and its affects on parameterization. We also studied the ability to quantify these factors for different soil moisture contents in order to define how the factors controlling the shape coefficient vary with changes in soil water pressure head. The relation between measured and estimated unsaturated hydraulic conductivity at various heads shows that rapid initial drainage, that changes the air-filled pore properties, creates a

  12. Multiscale analysis of nonlinear systems using computational homology

    Energy Technology Data Exchange (ETDEWEB)

    Konstantin Mischaikow; Michael Schatz; William Kalies; Thomas Wanner

    2010-05-24

    This is a collaborative project between the principal investigators. However, as is to be expected, different PIs have greater focus on different aspects of the project. This report lists these major directions of research which were pursued during the funding period: (1) Computational Homology in Fluids - For the computational homology effort in thermal convection, the focus of the work during the first two years of the funding period included: (1) A clear demonstration that homology can sensitively detect the presence or absence of an important flow symmetry, (2) An investigation of homology as a probe for flow dynamics, and (3) The construction of a new convection apparatus for probing the effects of large-aspect-ratio. (2) Computational Homology in Cardiac Dynamics - We have initiated an effort to test the use of homology in characterizing data from both laboratory experiments and numerical simulations of arrhythmia in the heart. Recently, the use of high speed, high sensitivity digital imaging in conjunction with voltage sensitive fluorescent dyes has enabled researchers to visualize electrical activity on the surface of cardiac tissue, both in vitro and in vivo. (3) Magnetohydrodynamics - A new research direction is to use computational homology to analyze results of large scale simulations of 2D turbulence in the presence of magnetic fields. Such simulations are relevant to the dynamics of black hole accretion disks. The complex flow patterns from simulations exhibit strong qualitative changes as a function of magnetic field strength. Efforts to characterize the pattern changes using Fourier methods and wavelet analysis have been unsuccessful. (4) Granular Flow - two experts in the area of granular media are studying 2D model experiments of earthquake dynamics where the stress fields can be measured; these stress fields from complex patterns of 'force chains' that may be amenable to analysis using computational homology. (5) Microstructure

  13. Multiscale analysis of nonlinear systems using computational homology

    Energy Technology Data Exchange (ETDEWEB)

    Konstantin Mischaikow, Rutgers University/Georgia Institute of Technology, Michael Schatz, Georgia Institute of Technology, William Kalies, Florida Atlantic University, Thomas Wanner,George Mason University

    2010-05-19

    This is a collaborative project between the principal investigators. However, as is to be expected, different PIs have greater focus on different aspects of the project. This report lists these major directions of research which were pursued during the funding period: (1) Computational Homology in Fluids - For the computational homology effort in thermal convection, the focus of the work during the first two years of the funding period included: (1) A clear demonstration that homology can sensitively detect the presence or absence of an important flow symmetry, (2) An investigation of homology as a probe for flow dynamics, and (3) The construction of a new convection apparatus for probing the effects of large-aspect-ratio. (2) Computational Homology in Cardiac Dynamics - We have initiated an effort to test the use of homology in characterizing data from both laboratory experiments and numerical simulations of arrhythmia in the heart. Recently, the use of high speed, high sensitivity digital imaging in conjunction with voltage sensitive fluorescent dyes has enabled researchers to visualize electrical activity on the surface of cardiac tissue, both in vitro and in vivo. (3) Magnetohydrodynamics - A new research direction is to use computational homology to analyze results of large scale simulations of 2D turbulence in the presence of magnetic fields. Such simulations are relevant to the dynamics of black hole accretion disks. The complex flow patterns from simulations exhibit strong qualitative changes as a function of magnetic field strength. Efforts to characterize the pattern changes using Fourier methods and wavelet analysis have been unsuccessful. (4) Granular Flow - two experts in the area of granular media are studying 2D model experiments of earthquake dynamics where the stress fields can be measured; these stress fields from complex patterns of 'force chains' that may be amenable to analysis using computational homology. (5) Microstructure

  14. A comparative evaluation of Cone Beam Computed Tomography (CBCT) and Multi-Slice CT (MSCT). Part II: On 3D model accuracy

    Energy Technology Data Exchange (ETDEWEB)

    Liang Xin, E-mail: Xin.Liang@med.kuleuven.b [Oral Imaging Centre, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, Catholic University of Leuven (Belgium); College of Stomatology, Dalian Medical University (China); Lambrichts, Ivo, E-mail: Ivo.Lambrichts@uhasselt.b [Department of Basic Medical Sciences, Histology and Electron Microscopy, Faculty of Medicine, University of Hasselt, Diepenbeek (Belgium); Sun Yi, E-mail: Sunyihello@hotmail.co [Oral Imaging Centre, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, Catholic University of Leuven (Belgium); Denis, Kathleen, E-mail: kathleen.denis@groept.b [Department of Industrial Sciences and Techology-Engineering (IWT), XIOS Hogeschool Limburg, Hasselt (Belgium); Hassan, Bassam, E-mail: b.hassan@acta.n [Department of Oral Radiology, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam (Netherlands); Li Limin, E-mail: Limin.Li@uz.kuleuven.b [Department of Paediatric Dentistry and Special Dental Care, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, Catholic University of Leuven (Belgium); Pauwels, Ruben, E-mail: Ruben.Pauwels@med.kuleuven.b [Oral Imaging Centre, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, Catholic University of Leuven (Belgium); Jacobs, Reinhilde, E-mail: Reinhilde.Jacobs@uz.kuleuven.b [Oral Imaging Centre, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, Catholic University of Leuven (Belgium)

    2010-08-15

    Aim: The study aim was to compare the geometric accuracy of three-dimensional (3D) surface model reconstructions between five Cone Beam Computed Tomography (CBCT) scanners and one Multi-Slice CT (MSCT) system. Materials and methods: A dry human mandible was scanned with five CBCT systems (NewTom 3G, Accuitomo 3D, i-CAT, Galileos, Scanora 3D) and one MSCT scanner (Somatom Sensation 16). A 3D surface bone model was created from the six systems. The reference (gold standard) 3D model was obtained with a high resolution laser surface scanner. The 3D models from the five systems were compared with the gold standard using a point-based rigid registration algorithm. Results: The mean deviation from the gold standard for MSCT was 0.137 mm and for CBCT were 0.282, 0.225, 0.165, 0.386 and 0.206 mm for the i-CAT, Accuitomo, NewTom, Scanora and Galileos, respectively. Conclusion: The results show that the accuracy of CBCT 3D surface model reconstructions is somewhat lower but acceptable comparing to MSCT from the gold standard.

  15. Enveloped viruses understood via multiscale simulation: computer-aided vaccine design

    Science.gov (United States)

    Shreif, Z.; Adhangale, P.; Cheluvaraja, S.; Perera, R.; Kuhn, R.; Ortoleva, P.

    Enveloped viruses are viewed as an opportunity to understand how highly organized and functional biosystems can emerge from a collection of millions of chaotically moving atoms. They are an intermediate level of complexity between macromolecules and bacteria. They are a natural system for testing theories of self-assembly and structural transitions, and for demonstrating the derivation of principles of microbiology from laws of molecular physics. As some constitute threats to human health, a computer-aided vaccine and drug design strategy that would follow from a quantitative model would be an important contribution. However, current molecular dynamics simulation approaches are not practical for modeling such systems. Our multiscale approach simultaneously accounts for the outer protein net and inner protein/genomic core, and their less structured membranous material and host fluid. It follows from a rigorous multiscale deductive analysis of laws of molecular physics. Two types of order parameters are introduced: (1) those for structures wherein constituent molecules retain long-lived connectivity (they specify the nanoscale structure as a deformation from a reference configuration) and (2) those for which there is no connectivity but organization is maintained on the average (they are field variables such as mass density or measures of preferred orientation). Rigorous multiscale techniques are used to derive equations for the order parameters dynamics. The equations account for thermal-average forces, diffusion coefficients, and effects of random forces. Statistical properties of the atomic-scale fluctuations and the order parameters are co-evolved. By combining rigorous multiscale techniques and modern supercomputing, systems of extreme complexity can be modeled.

  16. A Stochastic Quality Metric for Optimal Control of Active Camera Network Configurations for 3D Computer Vision Tasks

    OpenAIRE

    Ilie, Adrian; Welch, Greg; Macenko, Marc

    2008-01-01

    International audience We present a stochastic state-space quality metric for use in controlling active camera networks aimed at 3D vision tasks such as surveillance, motion tracking, and 3D shape/appearance reconstruction. Specifically, the metric provides an estimate of the aggregate steady-state uncertainty of the 3D resolution of the objects of interest, as a function of camera parameters such as pan, tilt, and zoom. The use of stochastic state-space models for the quality metric resul...

  17. Stem cell competition in the gut: insights from multi-scale computational modelling.

    Science.gov (United States)

    Thalheim, Torsten; Buske, Peter; Przybilla, Jens; Rother, Karen; Loeffler, Markus; Galle, Joerg

    2016-08-01

    Three-dimensional (3D) computational tissue models can provide a comprehensive description of tissue dynamics at the molecular, cellular and tissue level. Moreover, they can support the development of hypotheses about cellular interactions and about synergies between major signalling pathways. We exemplify these capabilities by simulation of a 3D single-cell-based model of mouse small intestinal crypts. We analyse the impact of lineage specification, distribution and cellular lifespan on clonal competition and study effects of Notch- and Wnt activation on fixation of mutations within the tissue. Based on these results, we predict that experimentally observed synergistic effects between autonomous Notch- and Wnt signalling in triggering intestinal tumourigenesis originate in the suppression of Wnt-dependent secretory lineage specification by Notch, giving rise to an increased fixation probability of Wnt-activating mutations. Our study demonstrates that 3D computational tissue models can support a mechanistic understanding of long-term tissue dynamics under homeostasis and during transformation. PMID:27534699

  18. Automatic reconstruction of 3D urban landscape by computing connected regions and assigning them an average altitude from LiDAR point cloud image

    Science.gov (United States)

    Kawata, Yoshiyuki; Koizumi, Kohei

    2014-10-01

    The demand of 3D city modeling has been increasing in many applications such as urban planing, computer gaming with realistic city environment, car navigation system with showing 3D city map, virtual city tourism inviting future visitors to a virtual city walkthrough and others. We proposed a simple method for reconstructing a 3D urban landscape from airborne LiDAR point cloud data. The automatic reconstruction method of a 3D urban landscape was implemented by the integration of all connected regions, which were extracted and extruded from the altitude mask images. These mask images were generated from the gray scale LiDAR image by the altitude threshold ranges. In this study we demonstrated successfully in the case of Kanazawa city center scene by applying the proposed method to the airborne LiDAR point cloud data.

  19. Multiscale mechanobiology: computational models for integrating molecules to multicellular systems.

    Science.gov (United States)

    Mak, Michael; Kim, Taeyoon; Zaman, Muhammad H; Kamm, Roger D

    2015-10-01

    Mechanical signals exist throughout the biological landscape. Across all scales, these signals, in the form of force, stiffness, and deformations, are generated and processed, resulting in an active mechanobiological circuit that controls many fundamental aspects of life, from protein unfolding and cytoskeletal remodeling to collective cell motions. The multiple scales and complex feedback involved present a challenge for fully understanding the nature of this circuit, particularly in development and disease in which it has been implicated. Computational models that accurately predict and are based on experimental data enable a means to integrate basic principles and explore fine details of mechanosensing and mechanotransduction in and across all levels of biological systems. Here we review recent advances in these models along with supporting and emerging experimental findings.

  20. Lagrangian Finite Element Method for 3D time-dependent viscoelastic flow computation using integral constitutive models

    DEFF Research Database (Denmark)

    Rasmussen, Henrik Koblitz

    2000-01-01

    A new technique for the numerical 3D simulation of time dependent flow of viscoelastic fluid is presented. The technique is based on a Lagrangian kinematics description of the fluid flow. The fluid is described by the Rivlin Sawyer integral constitutive equation. The method (referred to as the 3D...... Lagrangian Integral Method) is a finite element method where Galerkons method is used for solving the governing equation in rectangular coordinates numerically. In the present implementation the velocity and pressure fields are approximated with tri-linear and constant shape functions, respectivly.The 3D LIM......) and polymeric solutions. Secondly, the 3D-LIM has also been applied to calculate the inflation of a thick sheet of a polymeric melt into a elliptic cylinder. These problems all include free surfaces. As the governing equations are solved for the particle positions, the motion of surfaces can be followed easily...

  1. Linking microscopic spatial patterns of tissue destruction in emphysema to macroscopic decline in stiffness using a 3D computational model.

    Directory of Open Access Journals (Sweden)

    Harikrishnan Parameswaran

    2011-04-01

    Full Text Available Pulmonary emphysema is a connective tissue disease characterized by the progressive destruction of alveolar walls leading to airspace enlargement and decreased elastic recoil of the lung. However, the relationship between microscopic tissue structure and decline in stiffness of the lung is not well understood. In this study, we developed a 3D computational model of lung tissue in which a pre-strained cuboidal block of tissue was represented by a tessellation of space filling polyhedra, with each polyhedral unit-cell representing an alveolus. Destruction of alveolar walls was mimicked by eliminating faces that separate two polyhedral either randomly or in a spatially correlated manner, in which the highest force bearing walls were removed at each step. Simulations were carried out to establish a link between the geometries that emerged and the rate of decline in bulk modulus of the tissue block. The spatially correlated process set up by the force-based destruction lead to a significantly faster rate of decline in bulk modulus accompanied by highly heterogeneous structures than the random destruction pattern. Using the Karhunen-Loève transformation, an estimator of the change in bulk modulus from the first four moments of airspace cell volumes was setup. Simulations were then obtained for tissue destruction with different idealized alveolar geometry, levels of pre-strain, linear and nonlinear elasticity assumptions for alveolar walls and also mixed destruction patterns where both random and force-based destruction occurs simultaneously. In all these cases, the change in bulk modulus from cell volumes was accurately estimated. We conclude that microscopic structural changes in emphysema and the associated decline in tissue stiffness are linked by the spatial pattern of the destruction process.

  2. Linking microscopic spatial patterns of tissue destruction in emphysema to macroscopic decline in stiffness using a 3D computational model.

    Science.gov (United States)

    Parameswaran, Harikrishnan; Majumdar, Arnab; Suki, Béla

    2011-04-01

    Pulmonary emphysema is a connective tissue disease characterized by the progressive destruction of alveolar walls leading to airspace enlargement and decreased elastic recoil of the lung. However, the relationship between microscopic tissue structure and decline in stiffness of the lung is not well understood. In this study, we developed a 3D computational model of lung tissue in which a pre-strained cuboidal block of tissue was represented by a tessellation of space filling polyhedra, with each polyhedral unit-cell representing an alveolus. Destruction of alveolar walls was mimicked by eliminating faces that separate two polyhedral either randomly or in a spatially correlated manner, in which the highest force bearing walls were removed at each step. Simulations were carried out to establish a link between the geometries that emerged and the rate of decline in bulk modulus of the tissue block. The spatially correlated process set up by the force-based destruction lead to a significantly faster rate of decline in bulk modulus accompanied by highly heterogeneous structures than the random destruction pattern. Using the Karhunen-Loève transformation, an estimator of the change in bulk modulus from the first four moments of airspace cell volumes was setup. Simulations were then obtained for tissue destruction with different idealized alveolar geometry, levels of pre-strain, linear and nonlinear elasticity assumptions for alveolar walls and also mixed destruction patterns where both random and force-based destruction occurs simultaneously. In all these cases, the change in bulk modulus from cell volumes was accurately estimated. We conclude that microscopic structural changes in emphysema and the associated decline in tissue stiffness are linked by the spatial pattern of the destruction process. PMID:21533072

  3. Multi-level 3D non-LTE computations of lithium lines in the metal-poor halo stars HD140283 and HD84937

    CERN Document Server

    Asplund, M; Botnen, A

    2003-01-01

    The lithium abundances in metal-poor halo stars are of importance for cosmology, galaxy evolution and stellar structure. In an attempt to study possible systematic errors in the derived Li abundances, the line formation of LiI lines has been investigated by means of realistic 3D hydrodynamical model atmospheres of halo stars and 3D non-LTE radiative transfer calculations. These are the first detailed 3D non-LTE computations reported employing a multi-level atomic model showing that such problems are now computationally tractable. The detailed computations reveal that the LiI population has a strong influence from the radiation field rather than the local gas temperature, indicating that the low derived Li abundances found by Asplund et al. (1999) are an artifact of their assumption of LTE. Relative to 3D LTE, the detailed calculations show pronounced over-ionization. In terms of abundances the 3D non-LTE values are within 0.05 dex of the 1D non-LTE results for the particular cases of HD140283 and HD84937, whi...

  4. Multiscale approach including microfibril scale to assess elastic constants of cortical bone based on neural network computation and homogenization method

    CERN Document Server

    Barkaoui, Abdelwahed; Tarek, Merzouki; Hambli, Ridha; Ali, Mkaddem

    2014-01-01

    The complexity and heterogeneity of bone tissue require a multiscale modelling to understand its mechanical behaviour and its remodelling mechanisms. In this paper, a novel multiscale hierarchical approach including microfibril scale based on hybrid neural network computation and homogenisation equations was developed to link nanoscopic and macroscopic scales to estimate the elastic properties of human cortical bone. The multiscale model is divided into three main phases: (i) in step 0, the elastic constants of collagen-water and mineral-water composites are calculated by averaging the upper and lower Hill bounds; (ii) in step 1, the elastic properties of the collagen microfibril are computed using a trained neural network simulation. Finite element (FE) calculation is performed at nanoscopic levels to provide a database to train an in-house neural network program; (iii) in steps 2 to 10 from fibril to continuum cortical bone tissue, homogenisation equations are used to perform the computation at the higher s...

  5. Audio-visual perception of 3D cinematography: an fMRI study using condition-based and computation-based analyses.

    Directory of Open Access Journals (Sweden)

    Akitoshi Ogawa

    Full Text Available The use of naturalistic stimuli to probe sensory functions in the human brain is gaining increasing interest. Previous imaging studies examined brain activity associated with the processing of cinematographic material using both standard "condition-based" designs, as well as "computational" methods based on the extraction of time-varying features of the stimuli (e.g. motion. Here, we exploited both approaches to investigate the neural correlates of complex visual and auditory spatial signals in cinematography. In the first experiment, the participants watched a piece of a commercial movie presented in four blocked conditions: 3D vision with surround sounds (3D-Surround, 3D with monaural sound (3D-Mono, 2D-Surround, and 2D-Mono. In the second experiment, they watched two different segments of the movie both presented continuously in 3D-Surround. The blocked presentation served for standard condition-based analyses, while all datasets were submitted to computation-based analyses. The latter assessed where activity co-varied with visual disparity signals and the complexity of auditory multi-sources signals. The blocked analyses associated 3D viewing with the activation of the dorsal and lateral occipital cortex and superior parietal lobule, while the surround sounds activated the superior and middle temporal gyri (S/MTG. The computation-based analyses revealed the effects of absolute disparity in dorsal occipital and posterior parietal cortices and of disparity gradients in the posterior middle temporal gyrus plus the inferior frontal gyrus. The complexity of the surround sounds was associated with activity in specific sub-regions of S/MTG, even after accounting for changes of sound intensity. These results demonstrate that the processing of naturalistic audio-visual signals entails an extensive set of visual and auditory areas, and that computation-based analyses can track the contribution of complex spatial aspects characterizing such life

  6. Audio-visual perception of 3D cinematography: an fMRI study using condition-based and computation-based analyses.

    Science.gov (United States)

    Ogawa, Akitoshi; Bordier, Cecile; Macaluso, Emiliano

    2013-01-01

    The use of naturalistic stimuli to probe sensory functions in the human brain is gaining increasing interest. Previous imaging studies examined brain activity associated with the processing of cinematographic material using both standard "condition-based" designs, as well as "computational" methods based on the extraction of time-varying features of the stimuli (e.g. motion). Here, we exploited both approaches to investigate the neural correlates of complex visual and auditory spatial signals in cinematography. In the first experiment, the participants watched a piece of a commercial movie presented in four blocked conditions: 3D vision with surround sounds (3D-Surround), 3D with monaural sound (3D-Mono), 2D-Surround, and 2D-Mono. In the second experiment, they watched two different segments of the movie both presented continuously in 3D-Surround. The blocked presentation served for standard condition-based analyses, while all datasets were submitted to computation-based analyses. The latter assessed where activity co-varied with visual disparity signals and the complexity of auditory multi-sources signals. The blocked analyses associated 3D viewing with the activation of the dorsal and lateral occipital cortex and superior parietal lobule, while the surround sounds activated the superior and middle temporal gyri (S/MTG). The computation-based analyses revealed the effects of absolute disparity in dorsal occipital and posterior parietal cortices and of disparity gradients in the posterior middle temporal gyrus plus the inferior frontal gyrus. The complexity of the surround sounds was associated with activity in specific sub-regions of S/MTG, even after accounting for changes of sound intensity. These results demonstrate that the processing of naturalistic audio-visual signals entails an extensive set of visual and auditory areas, and that computation-based analyses can track the contribution of complex spatial aspects characterizing such life-like stimuli. PMID

  7. A Computational Investigation of the Finite-Time Blow-Up of the 3D Incompressible Euler Equations Based on the Voigt Regularization

    CERN Document Server

    Larios, Adam; Titi, Edriss S; Wingate, Beth

    2015-01-01

    We report the results of a computational investigation of two recently proved blow-up criteria for the 3D incompressible Euler equations. These criteria are based on an inviscid regularization of the Euler equations known as the 3D Euler-Voigt equations. The latter are known to be globally well-posed. Moreover, simulations of the 3D Euler-Voigt equations also require less resolution than simulations of the 3D Euler equations for fixed values of the regularization parameter $\\alpha>0$. Therefore, the new blow-up criteria allow one to gain information about possible singularity formation in the 3D Euler equations indirectly; namely, by simulating the better-behaved 3D Euler-Voigt equations. The new criteria are only known to be sufficient criteria for blow-up. Therefore, to test the robustness of the inviscid-regularization approach, we also investigate analogous criteria for blow-up of the 1D Burgers equation, where blow-up is well-known to occur.

  8. COMPUTATIONAL FLUID DYNAMICS FOR DENSE GAS-SOLID FLUIDIZED BEDS: A MULTI-SCALE MODELING STRATEGY

    Institute of Scientific and Technical Information of China (English)

    M. A. van der Hoef; M. van Sint Annaland; J. A. M. Kuipers

    2005-01-01

    Dense gas-particle flows are encountered in a variety of industrially important processes for large scale production of fuels, fertilizers and base chemicals. The scale-up of these processes is often problematic and is related to the intrinsic complexities of these flows which are unfortunately not yet fully understood despite significant efforts made in both academic and industrial research laboratories. In dense gas-particle flows both (effective) fluid-particle and (dissipative) particle-particle interactions need to be accounted for because these phenomena to a large extent govern the prevailing flow phenomena, i.e. the formation and evolution of heterogeneous structures. These structures have significant impact on the quality of the gas-solid contact and as a direct consequence thereof strongly affect the performance of the process. Due to the inherent complexity of dense gas-particles flows, we have adopted a multi-scale modeling approach in which both fluid-particle and particle-particle interactions can be properly accounted for. The idea is essentially that fundamental models, taking into account the relevant details of fluid-particle (lattice Boltzmann model) and particle-particle (discrete particle model) interactions, are used to develop closure laws to feed continuum models which can be used to compute the flow structures on a much larger (industrial) scale. Our multi-scale approach (see Fig. 1 ) involves the lattice Boltzmann model, the discrete particle model, the continuum model based on the kinetic theory of granular flow,and the discrete bubble model. In this paper we give an overview of the multi-scale modeling strategy, accompanied by illustrative computational results for bubble formation. In addition, areas which need substantial further attention will be highlighted.

  9. A comparative evaluation of Cone Beam Computed Tomography (CBCT) and Multi-Slice CT (MSCT). Part II: On 3D model accuracy

    NARCIS (Netherlands)

    X. Liang; I. Lambrichts; Y. Sun; K. Denis; B. Hassan; L. Li; R. Pauwels; R. Jacobs

    2010-01-01

    Aim: The study aim was to compare the geometric accuracy of three-dimensional (3D) surface model reconstructions between five Cone Beam Computed Tomography (CBCT) scanners and one Multi-Slice CT (MSCT) system. Materials and methods: A dry human mandible was scanned with five CBCT systems (NewTom 3G,

  10. Computational design of soft materials for the capture of Cs-137 in contaminated environments: From 2D covalent cucurbituril networks to 3D supramolecular materials

    Science.gov (United States)

    Pichierri, Fabio

    2016-08-01

    Using computational quantum chemistry methods we design novel 2D and 3D soft materials made of cucurbituril macrocycles covalently connected with each other via rigid linkers. Such covalent cucurbituril networks might be useful for the capture of radioactive Cs-137 (present as Cs+) in the contaminated environment.

  11. Stereological measures of trabecular bone structure: comparison of 3D micro computed tomography with 2D histological sections in human proximal tibial bone biopsies

    DEFF Research Database (Denmark)

    Thomsen, Jesper Skovhus; Laib, A.; Koller, B.;

    2005-01-01

    tibial metaphysis. The biopsies were embedded in methylmetacrylate before microCT scanning in a Scanco microCT 40 scanner at a resolution of 20 x 20 x 20 microm3, and the 3D data sets were analysed with a computer program. After microCT scanning, 16 sections were cut from the central 2 mm of each biopsy...

  12. Conformal-Based Surface Morphing and Multi-Scale Representation

    Directory of Open Access Journals (Sweden)

    Ka Chun Lam

    2014-05-01

    Full Text Available This paper presents two algorithms, based on conformal geometry, for the multi-scale representations of geometric shapes and surface morphing. A multi-scale surface representation aims to describe a 3D shape at different levels of geometric detail, which allows analyzing or editing surfaces at the global or local scales effectively. Surface morphing refers to the process of interpolating between two geometric shapes, which has been widely applied to estimate or analyze deformations in computer graphics, computer vision and medical imaging. In this work, we propose two geometric models for surface morphing and multi-scale representation for 3D surfaces. The basic idea is to represent a 3D surface by its mean curvature function, H, and conformal factor function λ, which uniquely determine the geometry of the surface according to Riemann surface theory. Once we have the (λ, H parameterization of the surface, post-processing of the surface can be done directly on the conformal parameter domain. In particular, the problem of multi-scale representations of shapes can be reduced to the signal filtering on the λ and H parameters. On the other hand, the surface morphing problem can be transformed to an interpolation process of two sets of (λ, H parameters. We test the proposed algorithms on 3D human face data and MRI-derived brain surfaces. Experimental results show that our proposed methods can effectively obtain multi-scale surface representations and give natural surface morphing results.

  13. High-throughput analysis of horse sperms' 3D swimming patterns using computational on-chip imaging.

    Science.gov (United States)

    Su, Ting-Wei; Choi, Inkyum; Feng, Jiawen; Huang, Kalvin; Ozcan, Aydogan

    2016-06-01

    Using a high-throughput optical tracking technique that is based on partially-coherent digital in-line holography, here we report a detailed analysis of the statistical behavior of horse sperms' three-dimensional (3D) swimming dynamics. This dual-color and dual-angle lensfree imaging platform enables us to track individual 3D trajectories of ∼1000 horse sperms at sub-micron level within a sample volume of ∼9μL at a frame rate of 143 frames per second (FPS) and collect thousands of sperm trajectories within a few hours for statistical analysis of their 3D dynamics. Using this high-throughput imaging platform, we recorded >17,000 horse sperm trajectories that can be grouped into six major categories: irregular, linear, planar, helical, ribbon, and hyperactivated, where the hyperactivated swimming patterns can be further divided into four sub-categories, namely hyper-progressive, hyper-planar, hyper-ribbon, and star-spin. The large spatio-temporal statistics that we collected with this 3D tracking platform revealed that irregular, planar, and ribbon trajectories are the dominant 3D swimming patterns observed in horse sperms, which altogether account for >97% of the trajectories that we imaged in plasma-free semen extender medium. Through our experiments we also found out that horse seminal plasma in general increases sperms' straightness in their 3D trajectories, enhancing the relative percentage of linear swimming patterns and suppressing planar swimming patterns, while barely affecting the overall percentage of ribbon patterns. PMID:26826909

  14. Bootstrapping 3D fermions

    Science.gov (United States)

    Iliesiu, Luca; Kos, Filip; Poland, David; Pufu, Silviu S.; Simmons-Duffin, David; Yacoby, Ran

    2016-03-01

    We study the conformal bootstrap for a 4-point function of fermions in 3D. We first introduce an embedding formalism for 3D spinors and compute the conformal blocks appearing in fermion 4-point functions. Using these results, we find general bounds on the dimensions of operators appearing in the ψ × ψ OPE, and also on the central charge C T . We observe features in our bounds that coincide with scaling dimensions in the GrossNeveu models at large N . We also speculate that other features could coincide with a fermionic CFT containing no relevant scalar operators.

  15. TRIO a general computer code for reactor 3-D flows analysis. Application to a LMFBR hot plenum

    International Nuclear Information System (INIS)

    TRIO is a code developed at CEA to investigate general incompressible 2D and 3D viscous flows. Two calculations are presented: the lid driven cubic cavity at Re=400; steady state (velocity and temperature field) of a LMFBR hot plenum, carried out in order to prepare the calculation of a cold shock consecutive to a reactor scram. 8 refs., 26 figs.

  16. Equation-Free Multiscale Computation enabling microscopic simulators to perform system-level tasks

    CERN Document Server

    Kevrekidis, Yu G; Hyman, J M; Kevrekidis, P G; Runborg, O; Theodoropoulos, C; Kevrekidis, Ioannis G.; Hyman, James M.; Kevrekidis, Panagiotis G.; Runborg, Olof; Theodoropoulos, Constantinos

    2002-01-01

    We present and discuss a framework for computer-aided multiscale analysis, which enables models at a "fine" (microscopic/stochastic) level of description to perform modeling tasks at a "coarse" (macroscopic, systems) level. These macroscopic modeling tasks, yielding information over long time and large space scales, are accomplished through appropriately initialized calls to the microscopic simulator for only short times and small spatial domains. Our equation-free (EF) approach, when successful, can bypass the derivation of the macroscopic evolution equations when these equations conceptually exist but are not available in closed form. We discuss how the mathematics-assisted development of a computational superstructure may enable alternative descriptions of the problem physics (e.g. Lattice Boltzmann (LB), kinetic Monte Carlo (KMC) or Molecular Dynamics (MD) microscopic simulators, executed over relatively short time and space scales) to perform systems level tasks (integration over relatively large time an...

  17. Development of a stereolithography (STL input and computer numerical control (CNC output algorithm for an entry-level 3-D printer

    Directory of Open Access Journals (Sweden)

    Brown, Andrew

    2014-08-01

    Full Text Available This paper presents a prototype Stereolithography (STL file format slicing and tool-path generation algorithm, which serves as a data front-end for a Rapid Prototyping (RP entry- level three-dimensional (3-D printer. Used mainly in Additive Manufacturing (AM, 3-D printers are devices that apply plastic, ceramic, and metal, layer by layer, in all three dimensions on a flat surface (X, Y, and Z axis. 3-D printers, unfortunately, cannot print an object without a special algorithm that is required to create the Computer Numerical Control (CNC instructions for printing. An STL algorithm therefore forms a critical component for Layered Manufacturing (LM, also referred to as RP. The purpose of this study was to develop an algorithm that is capable of processing and slicing an STL file or multiple files, resulting in a tool-path, and finally compiling a CNC file for an entry-level 3- D printer. The prototype algorithm was implemented for an entry-level 3-D printer that utilises the Fused Deposition Modelling (FDM process or Solid Freeform Fabrication (SFF process; an AM technology. Following an experimental method, the full data flow path for the prototype algorithm was developed, starting with STL data files, and then processing the STL data file into a G-code file format by slicing the model and creating a tool-path. This layering method is used by most 3-D printers to turn a 2-D object into a 3-D object. The STL algorithm developed in this study presents innovative opportunities for LM, since it allows engineers and architects to transform their ideas easily into a solid model in a fast, simple, and cheap way. This is accomplished by allowing STL models to be sliced rapidly, effectively, and without error, and finally to be processed and prepared into a G-code print file.

  18. Hybrid 3-D rocket trajectory program. Part 1: Formulation and analysis. Part 2: Computer programming and user's instruction. [computerized simulation using three dimensional motion analysis

    Science.gov (United States)

    Huang, L. C. P.; Cook, R. A.

    1973-01-01

    Models utilizing various sub-sets of the six degrees of freedom are used in trajectory simulation. A 3-D model with only linear degrees of freedom is especially attractive, since the coefficients for the angular degrees of freedom are the most difficult to determine and the angular equations are the most time consuming for the computer to evaluate. A computer program is developed that uses three separate subsections to predict trajectories. A launch rail subsection is used until the rocket has left its launcher. The program then switches to a special 3-D section which computes motions in two linear and one angular degrees of freedom. When the rocket trims out, the program switches to the standard, three linear degrees of freedom model.

  19. Multiscale approach including microfibril scale to assess elastic constants of cortical bone based on neural network computation and homogenization method

    OpenAIRE

    Barkaoui, Abdelwahed; Chamekh, Abdessalem; Tarek, Merzouki; Hambli, Ridha; Ali, Mkaddem

    2013-01-01

    The complexity and heterogeneity of bone tissue require a multiscale modelling to understand its mechanical behaviour and its remodelling mechanisms. In this paper, a novel multiscale hierarchical approach including microfibril scale based on hybrid neural network computation and homogenisation equations was developed to link nanoscopic and macroscopic scales to estimate the elastic properties of human cortical bone. The multiscale model is divided into three main phases: (i) in step 0, the e...

  20. Cardiac C-arm computed tomography using a 3D + time ROI reconstruction method with spatial and temporal regularization

    Energy Technology Data Exchange (ETDEWEB)

    Mory, Cyril, E-mail: cyril.mory@philips.com [Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1044, INSA-Lyon, Université Lyon 1, F-69621 Villeurbanne Cedex (France); Philips Research Medisys, 33 rue de Verdun, 92156 Suresnes (France); Auvray, Vincent; Zhang, Bo [Philips Research Medisys, 33 rue de Verdun, 92156 Suresnes (France); Grass, Michael; Schäfer, Dirk [Philips Research, Röntgenstrasse 24–26, D-22335 Hamburg (Germany); Chen, S. James; Carroll, John D. [Department of Medicine, Division of Cardiology, University of Colorado Denver, 12605 East 16th Avenue, Aurora, Colorado 80045 (United States); Rit, Simon [Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1044, INSA-Lyon, Université Lyon 1 (France); Centre Léon Bérard, 28 rue Laënnec, F-69373 Lyon (France); Peyrin, Françoise [Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1044, INSA-Lyon, Université Lyon 1, F-69621 Villeurbanne Cedex (France); X-ray Imaging Group, European Synchrotron, Radiation Facility, BP 220, F-38043 Grenoble Cedex (France); Douek, Philippe; Boussel, Loïc [Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1044, INSA-Lyon, Université Lyon 1 (France); Hospices Civils de Lyon, 28 Avenue du Doyen Jean Lépine, 69500 Bron (France)

    2014-02-15

    Purpose: Reconstruction of the beating heart in 3D + time in the catheter laboratory using only the available C-arm system would improve diagnosis, guidance, device sizing, and outcome control for intracardiac interventions, e.g., electrophysiology, valvular disease treatment, structural or congenital heart disease. To obtain such a reconstruction, the patient's electrocardiogram (ECG) must be recorded during the acquisition and used in the reconstruction. In this paper, the authors present a 4D reconstruction method aiming to reconstruct the heart from a single sweep 10 s acquisition. Methods: The authors introduce the 4D RecOnstructiOn using Spatial and TEmporal Regularization (short 4D ROOSTER) method, which reconstructs all cardiac phases at once, as a 3D + time volume. The algorithm alternates between a reconstruction step based on conjugate gradient and four regularization steps: enforcing positivity, averaging along time outside a motion mask that contains the heart and vessels, 3D spatial total variation minimization, and 1D temporal total variation minimization. Results: 4D ROOSTER recovers the different temporal representations of a moving Shepp and Logan phantom, and outperforms both ECG-gated simultaneous algebraic reconstruction technique and prior image constrained compressed sensing on a clinical case. It generates 3D + time reconstructions with sharp edges which can be used, for example, to estimate the patient's left ventricular ejection fraction. Conclusions: 4D ROOSTER can be applied for human cardiac C-arm CT, and potentially in other dynamic tomography areas. It can easily be adapted to other problems as regularization is decoupled from projection and back projection.

  1. Computational technology for analysis of 3D meso-structure effects on damage and failure of concrete

    OpenAIRE

    Wang, X.; Zhang, M.; Jivkov, A. P.

    2016-01-01

    Methodology for analysis of meso-structure effects on longer-scale mechanical response of concrete is developed. Efficient algorithms for particle generation and packing are proposed to represent 3D meso-structures as collections of discrete features distributed randomly in a continuous phase. Specialised to concrete, the continuous phase represents mortar, while the features are aggregates and voids. Intra- and inter-phase cohesive zones are used for failure initiation and crack propagation....

  2. A survey on stochastic multi-scale modeling in biomechanics: computational challenges

    CERN Document Server

    Favino, Marco; Pivkin, Igor

    2016-01-01

    During the last decade, multi-scale models in mechanics, bio-mechanics and life sciences have gained increasing attention. Using multi-scale approaches, effects on different time and length scales, such as, e.g., cellular and organ scale, can be coupled and their interaction can be studied. Clearly, this requires the development of new mathematical models and numerical methods for multi-scale problems, in order to provide reliable and efficient tools for the investigation of multi-scale effects. Here, we give an overview on existing numerical approaches for multi-scale simulations in bio-mechanics with particular emphasis on stochastic effects.

  3. Application of computer-aided multi-scale modelling framework – Aerosol case study

    DEFF Research Database (Denmark)

    Heitzig, Martina; Sin, Gürkan; Glarborg, Peter;

    the second part supports the modeller during the multi-scale scenario development and comparison. The second part of the modelling framework manages different multi-scale scenarios, supports in the systematic derivation of a new scenario and links the modelsfor the different scales according to the linking...... scheme of the multi-scale scenario. This is where the single-scale model development part is connected to the multi-scale scenario development part because it assists the modeller in providing the single-scale models that are being linked to form the multi-scale scenario. The single-scale model...

  4. Validity of computational hemodynamics in human arteries based on 3D time-of-flight MR angiography and 2D electrocardiogram gated phase contrast images

    Science.gov (United States)

    Yu, Huidan (Whitney); Chen, Xi; Chen, Rou; Wang, Zhiqiang; Lin, Chen; Kralik, Stephen; Zhao, Ye

    2015-11-01

    In this work, we demonstrate the validity of 4-D patient-specific computational hemodynamics (PSCH) based on 3-D time-of-flight (TOF) MR angiography (MRA) and 2-D electrocardiogram (ECG) gated phase contrast (PC) images. The mesoscale lattice Boltzmann method (LBM) is employed to segment morphological arterial geometry from TOF MRA, to extract velocity profiles from ECG PC images, and to simulate fluid dynamics on a unified GPU accelerated computational platform. Two healthy volunteers are recruited to participate in the study. For each volunteer, a 3-D high resolution TOF MRA image and 10 2-D ECG gated PC images are acquired to provide the morphological geometry and the time-varying flow velocity profiles for necessary inputs of the PSCH. Validation results will be presented through comparisons of LBM vs. 4D Flow Software for flow rates and LBM simulation vs. MRA measurement for blood flow velocity maps. Indiana University Health (IUH) Values Fund.

  5. Computational Biomodelling and Analysis of 3D Structure of HUMAN Proto-oncogene c-Rel: A Tumorigenesis Activator Protein

    Directory of Open Access Journals (Sweden)

    Atala Bihari Jena

    2013-09-01

    Full Text Available With the advent of biomedical research in the field of human science several protein are found in human body acts s a health hazard. The proto-oncogene c-Rel protein is mostly found in human is encoded by the REL gene and belongs to the Rel/NF- kB transcription factor family, which regulates a large variety of cellular functions. Proto-oncogene involved and plays a great role in differentiation and lymphopoiesis. Proto-oncogene may be harmful and cause cancer when they are mutated. To understand the operational mechanism of HUMAN Proto-oncogene c-Rel protein, it is imperative to understand the structural model of that particular protein but the three dimensional (3D structure has not yet been reported in Protein Data Bank (PDB. In the present study a complete structural analysis and 3-D modelling of HUMAN Proto-oncogene c-Rel of Homosapiens.Based on the PDB Blast report three dimensional structure of the Proto-oncogenec-Rel protein, was predicted by using the SWISS MODEL. Predicted model was further assessed by SAVES (PROCHEK, VERIFY 3D, ERRAT and Ramachandran Server, which show with acceptable scores and the reliability of final refined model. The overall result provides the evidence of good quality of model and furnishes an adequate foundation for functional analysis of experimentally derived crystal structures and also helps in cancer research with furnishes a novel starting point for structure based drug design of proto-oncogene c-Rel protein.

  6. A 3-D CE/SE Navier-Stokes Solver With Unstructured Hexahedral Grid for Computation of Near Field Jet Screech Noise

    Science.gov (United States)

    Loh, Ching Y.; Himansu, Ananda; Hultgren, Lennart S.

    2003-01-01

    A 3-D space-time CE/SE Navier-Stokes solver using an unstructured hexahedral grid is described and applied to a circular jet screech noise computation. The present numerical results for an underexpanded jet, corresponding to a fully expanded Mach number of 1.42, capture the dominant and nonaxisymmetric 'B' screech mode and are generally in good agreement with existing experiments.

  7. Multi-scale computation methods: Their applications in lithium-ion battery research and development

    Science.gov (United States)

    Siqi, Shi; Jian, Gao; Yue, Liu; Yan, Zhao; Qu, Wu; Wangwei, Ju; Chuying, Ouyang; Ruijuan, Xiao

    2016-01-01

    Based upon advances in theoretical algorithms, modeling and simulations, and computer technologies, the rational design of materials, cells, devices, and packs in the field of lithium-ion batteries is being realized incrementally and will at some point trigger a paradigm revolution by combining calculations and experiments linked by a big shared database, enabling accelerated development of the whole industrial chain. Theory and multi-scale modeling and simulation, as supplements to experimental efforts, can help greatly to close some of the current experimental and technological gaps, as well as predict path-independent properties and help to fundamentally understand path-independent performance in multiple spatial and temporal scales. Project supported by the National Natural Science Foundation of China (Grant Nos. 51372228 and 11234013), the National High Technology Research and Development Program of China (Grant No. 2015AA034201), and Shanghai Pujiang Program, China (Grant No. 14PJ1403900).

  8. A variational multiscale finite element method for monolithic ALE computations of shock hydrodynamics using nodal elements

    Science.gov (United States)

    Zeng, X.; Scovazzi, G.

    2016-06-01

    We present a monolithic arbitrary Lagrangian-Eulerian (ALE) finite element method for computing highly transient flows with strong shocks. We use a variational multiscale (VMS) approach to stabilize a piecewise-linear Galerkin formulation of the equations of compressible flows, and an entropy artificial viscosity to capture strong solution discontinuities. Our work demonstrates the feasibility of VMS methods for highly transient shock flows, an area of research for which the VMS literature is extremely scarce. In addition, the proposed monolithic ALE method is an alternative to the more commonly used Lagrangian+remap methods, in which, at each time step, a Lagrangian computation is followed by mesh smoothing and remap (conservative solution interpolation). Lagrangian+remap methods are the methods of choice in shock hydrodynamics computations because they provide nearly optimal mesh resolution in proximity of shock fronts. However, Lagrangian+remap methods are not well suited for imposing inflow and outflow boundary conditions. These issues offer an additional motivation for the proposed approach, in which we first perform the mesh motion, and then the flow computations using the monolithic ALE framework. The proposed method is second-order accurate and stable, as demonstrated by extensive numerical examples in two and three space dimensions.

  9. Sectional depiction of the pelvic floor by CT, MR imaging and sheet plastination: computer-aided correlation and 3D model

    International Nuclear Information System (INIS)

    The structures of the pelvic floor are clinically important but difficult to assess. To facilitate the understanding of the complicated pelvic floor anatomy on sectional images obtained by CT and MR imaging, and to make the representation more vivid, a computer-aided 3D model was created from a male and a female torso to develop a teaching tool. A male and a female cadaver torso were investigated by means of CT, MR imaging, and serial-section sheet plastination. A 3D reconstruction of the pelvic floor and adjacent structures was performed by fusion of CT and MR imaging data sets with sheet plastination sections. Corresponding sections from all three methods could be compared and visualized in their 3D context. Sheet plastination allows distinction of connective tissue, muscles, and pelvic organs down to a microscopic level. In combination with CT, MR imaging, and sheet plastination a 3D model of the pelvic floor offers a better understanding of the complex pelvic anatomy. This knowledge may be applied in the diagnostic imaging of urinary incontinence or prolapse and prior to prostate surgery. (orig.)

  10. Sectional depiction of the pelvic floor by CT, MR imaging and sheet plastination: computer-aided correlation and 3D model

    Energy Technology Data Exchange (ETDEWEB)

    Beyersdorff, D.; Taupitz, M.; Hamm, B. [Dept. of Radiology, Humboldt Univ., Berlin (Germany); Schiemann, T. [Inst. for Mathematics and Computer Science in Medicine, University of Hamburg (Germany); Kooijman, H. [Philips Medical Systems, Hamburg (Germany); Nicolas, V. [Dept. of Radiology and Nuclear Medicine, BG Kliniken Bergmannsheil, Bochum (Germany)

    2001-04-01

    The structures of the pelvic floor are clinically important but difficult to assess. To facilitate the understanding of the complicated pelvic floor anatomy on sectional images obtained by CT and MR imaging, and to make the representation more vivid, a computer-aided 3D model was created from a male and a female torso to develop a teaching tool. A male and a female cadaver torso were investigated by means of CT, MR imaging, and serial-section sheet plastination. A 3D reconstruction of the pelvic floor and adjacent structures was performed by fusion of CT and MR imaging data sets with sheet plastination sections. Corresponding sections from all three methods could be compared and visualized in their 3D context. Sheet plastination allows distinction of connective tissue, muscles, and pelvic organs down to a microscopic level. In combination with CT, MR imaging, and sheet plastination a 3D model of the pelvic floor offers a better understanding of the complex pelvic anatomy. This knowledge may be applied in the diagnostic imaging of urinary incontinence or prolapse and prior to prostate surgery. (orig.)

  11. Teaching Reform and Practice in Engineering Drawing Based on 3D Modeling with Computer%Teaching Reform and Practice in Engineering Drawing Based on 3D Modeling with Computer

    Institute of Scientific and Technical Information of China (English)

    WANG Jian-hua; HAO Yu-xin

    2011-01-01

    Based on the necessity of three dimensional modeling with computer in teaching reform, this paper is the summarization of reform practice of teaching engineering drawing in our institute. The teaching reform begins with three dimensional modeling that used computer instead of board. On the basis of target of teaching reform, set of teaching content, arrangement of class hour and teaching method, the research of teaching practice have been done, and very good effects in teaching of engineering drawing have been achieved.

  12. Simulation of dynamic behaviour of a digital displacement motor using transient 3d computational fluid dynamics analysis

    DEFF Research Database (Denmark)

    Rømer, Daniel; Johansen, Per; Pedersen, Henrik C.;

    2013-01-01

    A fast rotating 1500 rpm radial piston digital displacement motor connected to a 350 bar high pressure manifold is simulated by means of transient 3D CFD analysis of a single pressure chamber. The analysis includes dynamic piston and valve movement, influencing the boundaries of the fluid domain...... of the CFD analysis, the dynamic response of the pressure chamber and valve movement of a digital displacement motor is presented, along with the total efficiency of a multi-chamber motor at full and partial displacement. Simulation predicts that pressure over- and undershoot may be reduced to a few percent....... Movement of the low and high pressure valves is coupled to fluid forces and valve actuation is included to control the valve movement according to the pressure cycle of the digital displacement motor. The fluid domain is meshed using a structured/unstructured non-conformal mesh, which is updated throughout...

  13. Using 3D in Visualization

    DEFF Research Database (Denmark)

    Wood, Jo; Kirschenbauer, Sabine; Döllner, Jürgen;

    2005-01-01

    to display 3D imagery. The extra cartographic degree of freedom offered by using 3D is explored and offered as a motivation for employing 3D in visualization. The use of VR and the construction of virtual environments exploit navigational and behavioral realism, but become most usefil when combined...... with abstracted representations embedded in a 3D space. The interactions between development of geovisualization, the technology used to implement it and the theory surrounding cartographic representation are explored. The dominance of computing technologies, driven particularly by the gaming industry...

  14. Multiscale modeling and distributed computing to predict cosmesis outcome after a lumpectomy

    Science.gov (United States)

    Garbey, M.; Salmon, R.; Thanoon, D.; Bass, B. L.

    2013-07-01

    Surgery for early stage breast carcinoma is either total mastectomy (complete breast removal) or surgical lumpectomy (only tumor removal). The lumpectomy or partial mastectomy is intended to preserve a breast that satisfies the woman's cosmetic, emotional and physical needs. But in a fairly large number of cases the cosmetic outcome is not satisfactory. Today, predicting that surgery outcome is essentially based on heuristic. Modeling such a complex process must encompass multiple scales, in space from cells to tissue, as well as in time, from minutes for the tissue mechanics to months for healing. The goal of this paper is to present a first step in multiscale modeling of the long time scale prediction of breast shape after tumor resection. This task requires coupling very different mechanical and biological models with very different computing needs. We provide a simple illustration of the application of heterogeneous distributed computing and modular software design to speed up the model development. Our computational framework serves currently to test hypothesis on breast tissue healing in a pilot study with women who have been elected to undergo BCT and are being treated at the Methodist Hospital in Houston, TX.

  15. Towards an integrated multiscale simulation of turbulent clouds on PetaScale computers

    International Nuclear Information System (INIS)

    The development of precipitating warm clouds is affected by several effects of small-scale air turbulence including enhancement of droplet-droplet collision rate by turbulence, entrainment and mixing at the cloud edges, and coupling of mechanical and thermal energies at various scales. Large-scale computation is a viable research tool for quantifying these multiscale processes. Specifically, top-down large-eddy simulations (LES) of shallow convective clouds typically resolve scales of turbulent energy-containing eddies while the effects of turbulent cascade toward viscous dissipation are parameterized. Bottom-up hybrid direct numerical simulations (HDNS) of cloud microphysical processes resolve fully the dissipation-range flow scales but only partially the inertial subrange scales. it is desirable to systematically decrease the grid length in LES and increase the domain size in HDNS so that they can be better integrated to address the full range of scales and their coupling. In this paper, we discuss computational issues and physical modeling questions in expanding the ranges of scales realizable in LES and HDNS, and in bridging LES and HDNS. We review our on-going efforts in transforming our simulation codes towards PetaScale computing, in improving physical representations in LES and HDNS, and in developing better methods to analyze and interpret the simulation results.

  16. Multiscale Computational Analysis of Nitrogen and Oxygen Gas-Phase Thermochemistry in Hypersonic Flows

    Science.gov (United States)

    Bender, Jason D.

    Understanding hypersonic aerodynamics is important for the design of next-generation aerospace vehicles for space exploration, national security, and other applications. Ground-level experimental studies of hypersonic flows are difficult and expensive; thus, computational science plays a crucial role in this field. Computational fluid dynamics (CFD) simulations of extremely high-speed flows require models of chemical and thermal nonequilibrium processes, such as dissociation of diatomic molecules and vibrational energy relaxation. Current models are outdated and inadequate for advanced applications. We describe a multiscale computational study of gas-phase thermochemical processes in hypersonic flows, starting at the atomic scale and building systematically up to the continuum scale. The project was part of a larger effort centered on collaborations between aerospace scientists and computational chemists. We discuss the construction of potential energy surfaces for the N4, N2O2, and O4 systems, focusing especially on the multi-dimensional fitting problem. A new local fitting method named L-IMLS-G2 is presented and compared with a global fitting method. Then, we describe the theory of the quasiclassical trajectory (QCT) approach for modeling molecular collisions. We explain how we implemented the approach in a new parallel code for high-performance computing platforms. Results from billions of QCT simulations of high-energy N2 + N2, N2 + N, and N2 + O2 collisions are reported and analyzed. Reaction rate constants are calculated and sets of reactive trajectories are characterized at both thermal equilibrium and nonequilibrium conditions. The data shed light on fundamental mechanisms of dissociation and exchange reactions -- and their coupling to internal energy transfer processes -- in thermal environments typical of hypersonic flows. We discuss how the outcomes of this investigation and other related studies lay a rigorous foundation for new macroscopic models for

  17. The advantage of the three dimensional computed tomographic (3 D-CT for ensuring accurate bone incision in sagittal split ramus osteotomy

    Directory of Open Access Journals (Sweden)

    Coen Pramono D

    2005-03-01

    Full Text Available Functional and aesthetic dysgnathia surgery requires accurate pre-surgical planning, including the surgical technique to be used related with the difference of anatomical structures amongst individuals. Programs that simulate the surgery become increasingly important. This can be mediated by using a surgical model, conventional x-rays as panoramic, cephalometric projections and another sophisticated method such as a three dimensional computed tomography (3 D-CT. A patient who had undergone double jaw surgeries with difficult anatomical landmarks was presented. In this case the mandible foramens were seen highly relatively related to the sigmoid notches. Therefore, ensuring the bone incisions in sagittal split was presumed to be difficult. A 3D-CT was made and considered to be very helpful in supporting the pre-operative diagnostic.

  18. Automated detection of pulmonary embolism (PE) in computed tomographic pulmonary angiographic (CTPA) images: multiscale hierachical expectation-maximization segmentation of vessels and PEs

    Science.gov (United States)

    Zhou, Chuan; Chan, Heang-Ping; Hadjiiski, Lubomir M.; Chughtai, Aamer; Patel, Smita; Cascade, Philip N.; Sahiner, Berkman; Wei, Jun; Ge, Jun; Kazerooni, Ella A.

    2007-03-01

    CT pulmonary angiography (CTPA) has been reported to be an effective means for clinical diagnosis of pulmonary embolism (PE). We are developing a computer-aided detection (CAD) system to assist radiologist in PE detection in CTPA images. 3D multiscale filters in combination with a newly designed response function derived from the eigenvalues of Hessian matrices is used to enhance vascular structures including the vessel bifurcations and suppress non-vessel structures such as the lymphoid tissues surrounding the vessels. A hierarchical EM estimation is then used to segment the vessels by extracting the high response voxels at each scale. The segmented vessels are pre-screened for suspicious PE areas using a second adaptive multiscale EM estimation. A rule-based false positive (FP) reduction method was designed to identify the true PEs based on the features of PE and vessels. 43 CTPA scans were used as an independent test set to evaluate the performance of PE detection. Experienced chest radiologists identified the PE locations which were used as "gold standard". 435 PEs were identified in the artery branches, of which 172 and 263 were subsegmental and proximal to the subsegmental, respectively. The computer-detected volume was considered true positive (TP) when it overlapped with 10% or more of the gold standard PE volume. Our preliminary test results show that, at an average of 33 and 24 FPs/case, the sensitivities of our PE detection method were 81% and 78%, respectively, for proximal PEs, and 79% and 73%, respectively, for subsegmental PEs. The study demonstrates the feasibility that the automated method can identify PE accurately on CTPA images. Further study is underway to improve the sensitivity and reduce the FPs.

  19. PLOT3D user's manual

    Science.gov (United States)

    Walatka, Pamela P.; Buning, Pieter G.; Pierce, Larry; Elson, Patricia A.

    1990-01-01

    PLOT3D is a computer graphics program designed to visualize the grids and solutions of computational fluid dynamics. Seventy-four functions are available. Versions are available for many systems. PLOT3D can handle multiple grids with a million or more grid points, and can produce varieties of model renderings, such as wireframe or flat shaded. Output from PLOT3D can be used in animation programs. The first part of this manual is a tutorial that takes the reader, keystroke by keystroke, through a PLOT3D session. The second part of the manual contains reference chapters, including the helpfile, data file formats, advice on changing PLOT3D, and sample command files.

  20. Design, Fabrication and Computational Characterization of a 3D Micro-Valve Built by Multi-Photon Polymerization

    Directory of Open Access Journals (Sweden)

    Stratos Galanopoulos

    2014-08-01

    Full Text Available We report on the design, modeling and fabrication by multi-photon polymerization of a complex medical fluidic device. The physical dimensions of the built micro-valve prototype are compared to those of its computer-designed model. Important fabrication issues such as achieving high dimensional resolution and ability to control distortion due to shrinkage are presented and discussed. The operational performance of both multi-photon and CAD-created models under steady blood flow conditions was evaluated and compared through computational fluid dynamics analysis.

  1. An eye model for computational dosimetry using a multi-scale voxel phantom

    International Nuclear Information System (INIS)

    The lens of the eye is a radiosensitive tissue with cataract formation being the major concern. Recently reduced recommended dose limits to the lens of the eye have made understanding the dose to this tissue of increased importance. Due to memory limitations, the voxel resolution of computational phantoms used for radiation dose calculations is too large to accurately represent the dimensions of the eye. A revised eye model is constructed using physiological data for the dimensions of radiosensitive tissues, and is then transformed into a high-resolution voxel model. This eye model is combined with an existing set of whole body models to form a multi-scale voxel phantom, which is used with the MCNPX code to calculate radiation dose from various exposure types. This phantom provides an accurate representation of the radiation transport through the structures of the eye. Two alternate methods of including a high-resolution eye model within an existing whole body model are developed. When the Lattice Overlay method, the simpler of the two to define, is utilized, the computational penalty in terms of speed is noticeable and the figure of merit for the eye dose tally decreases by as much as a factor of two. When the Voxel Substitution method is applied, the penalty in speed is nearly trivial and the impact on the tally figure of merit is comparatively smaller. The origin of this difference in the code behavior may warrant further investigation

  2. Computational study on 3D structure of L-aspartic acid and L-glutamic acid: molecular descriptors and properties

    Directory of Open Access Journals (Sweden)

    Stefaniu Amalia

    2016-06-01

    Full Text Available The aim of this work is to provide a comprehensive and complex analysis of molecular descriptors and properties of two similar amino acids, L-Aspartic acid and L-Glutamic acid, using a software tool for calculations and properties predictions. As amino acids are model compounds for predicting the physical-chemical properties and behavior of biological, larger molecules as peptides or proteins, researches were focused on providing accurate mechanical calculations using: molecular/mechanical methods. Our study aims to initiate a linear scaling approach, by dividing a large system into small subsystems and performing the calculations for each, individually, then, embedding and correcting the information globally. The calculations were performed on the 3D structure of the studied amino acids that were first generated, as CPK model, and optimized by energy minimization. A comparative assay on their topological, molecular descriptors and properties was conducted, in vacuum and in water, using the Hartree-Fock model and second-order Møller-Plesset perturbation theory MP2 for predicting structure, energy and property calculations with Spartan’14 software. Values of molecular properties such as area, volume, polar surface area, polarizability, ovality, logP, dipole moment, HOMO-LUMO gap, distances and angles between atoms, were obtained. The results have been interpreted in terms of electronic effects of side chain groups, molecular deformability, steric factors and reactivity. This approach can be extended to other amino acids in order to predict protein-ligand interactions, important aspects in drug design studies and protein engineering.

  3. 3D video

    CERN Document Server

    Lucas, Laurent; Loscos, Céline

    2013-01-01

    While 3D vision has existed for many years, the use of 3D cameras and video-based modeling by the film industry has induced an explosion of interest for 3D acquisition technology, 3D content and 3D displays. As such, 3D video has become one of the new technology trends of this century.The chapters in this book cover a large spectrum of areas connected to 3D video, which are presented both theoretically and technologically, while taking into account both physiological and perceptual aspects. Stepping away from traditional 3D vision, the authors, all currently involved in these areas, provide th

  4. Computer simulation of 3D steady and 2D transient loading of CASTOR 440/84 using FEM

    International Nuclear Information System (INIS)

    The system of computer codes, developed at the NRI Rez, plc. for the CEZ a.s. company, is described, aimed to the realistic best estimate evaluations of the temperature field in the CASTOR 440/84 container, which is used for the Dukovany NPP spent fuel. (author)

  5. A New Energy-Based Method for 3-D Finite-Element Nonlinear Flux Linkage computation of Electrical Machines

    DEFF Research Database (Denmark)

    Lu, Kaiyuan; Rasmussen, Peter Omand; Ritchie, Ewen

    2011-01-01

    introduced in this paper is much easier to use and is computational faster. This method is derived based on the “apparent energy.” Calculation of the nonlinear flux linkage from this energy avoids numerical differentiation, which is sensitive to numerical errors but is required in the traditional energy...

  6. Reducing computational costs in large scale 3D EIT by using a sparse Jacobian matrix with block-wise CGLS reconstruction

    International Nuclear Information System (INIS)

    Electrical impedance tomography (EIT) is a fast and cost-effective technique to provide a tomographic conductivity image of a subject from boundary current–voltage data. This paper proposes a time and memory efficient method for solving a large scale 3D EIT inverse problem using a parallel conjugate gradient (CG) algorithm. The 3D EIT system with a large number of measurement data can produce a large size of Jacobian matrix; this could cause difficulties in computer storage and the inversion process. One of challenges in 3D EIT is to decrease the reconstruction time and memory usage, at the same time retaining the image quality. Firstly, a sparse matrix reduction technique is proposed using thresholding to set very small values of the Jacobian matrix to zero. By adjusting the Jacobian matrix into a sparse format, the element with zeros would be eliminated, which results in a saving of memory requirement. Secondly, a block-wise CG method for parallel reconstruction has been developed. The proposed method has been tested using simulated data as well as experimental test samples. Sparse Jacobian with a block-wise CG enables the large scale EIT problem to be solved efficiently. Image quality measures are presented to quantify the effect of sparse matrix reduction in reconstruction results. (paper)

  7. Development and evaluation of a new 3-D digitization and computer graphic system to study the anatomic tissue and restoration surfaces.

    Science.gov (United States)

    Dastane, A; Vaidyanathan, T K; Vaidyanathan, J; Mehra, R; Hesby, R

    1996-01-01

    It is necessary to visualize and reconstruct tissue anatomic surfaces accurately for a variety of oral rehabilitation applications such as surface wear characterization and automated fabrication of dental restorations, accuracy of reproduction of impression and die materials, etc. In this investigation, a 3-D digitization and computer-graphic system was developed for surface characterization. The hardware consists of a profiler assembly for digitization in an MTS biomechanical test system with an artificial mouth, an IBM PS/2 computer model 70 for data processing and a Hewlett-Packard laser printer for hardcopy outputs. The software used includes a commercially available Surfer 3-D graphics package, a public domain data-fitting alignment software and an inhouse Pascal program for intercommunication plus some other limited tasks. Surfaces were digitized before and after rotation by angular displacement, the digital data were interpolated by Surfer to provide a data grid and the surfaces were computer graphically reconstructed: Misaligned surfaces were aligned by the data-fitting alignment software under different choices of parameters. The effect of different interpolation parameters (e.g. grid size, method of interpolation) and extent of rotation on the alignment accuracy was determined. The results indicate that improved alignment accuracy results from optimization of interpolation parameters and minimization of the initial misorientation between the digitized surfaces. The method provides important advantages for surface reconstruction and visualization, such as overlay of sequentially generated surfaces and accurate alignment of pairs of surfaces with small misalignment.

  8. The use of 3D computed tomography reconstruction in medico-legal testimony regarding injuries in living victims - Risks and benefits.

    Science.gov (United States)

    Borowska-Solonynko, Aleksandra; Solonynko, Bohdan

    2015-02-01

    Forensic pathologists are often called upon to determine the mechanism and severity of injuries in living individuals. Such expert testimony is often based solely on hand-written clinical notes. The victims' injuries may also be visualized via three-dimensional (3D) reconstruction of computed tomography (CT) images. This method has certain benefits but is not free from limitations. This paper presents two case reports. The first case is that of a female who was brought to the hospital with a knife thrust into her body. The prosecutor's questions focused on the wound channel. The information obtained from the patient's medical records was very general with many contradictory statements. A re-evaluation of the available CT scan data and a subsequent 3D reconstruction helped determine the exact course of the wound channel. The other case was that of a young male, hospitalized based on CT evidence of bilateral rib fractions, who claimed to have been assaulted by police officers. Court expert witnesses were already in possession of a 3D reconstruction showing symmetrical fractures of the patient's lower ribs with bone fragment displacement. An expert witness in radiology definitively excluded the presence of any actual fractures, and explained their apparent visibility in the three-dimensionally reconstructed image as a motion artifact. These two cases suggest that a professionally conducted 3D CT reconstruction is a very useful tool in providing expert testimony on injuries in living victims. However, the deceptive simplicity of conducting such a reconstruction may encourage inexperienced individuals to undertake it, and thus lead to erroneous conclusions. PMID:25623187

  9. A computer-assisted 3D model for analyzing the aggregation of tumorigenic cells reveals specialized behaviors and unique cell types that facilitate aggregate coalescence.

    Directory of Open Access Journals (Sweden)

    Amanda Scherer

    Full Text Available We have developed a 4D computer-assisted reconstruction and motion analysis system, J3D-DIAS 4.1, and applied it to the reconstruction and motion analysis of tumorigenic cells in a 3D matrix. The system is unique in that it is fast, high-resolution, acquires optical sections using DIC microscopy (hence there is no associated photoxicity, and is capable of long-term 4D reconstruction. Specifically, a z-series at 5 μm increments can be acquired in less than a minute on tissue samples embedded in a 1.5 mm thick 3D Matrigel matrix. Reconstruction can be repeated at intervals as short as every minute and continued for 30 days or longer. Images are converted to mathematical representations from which quantitative parameters can be derived. Application of this system to cancer cells from established lines and fresh tumor tissue has revealed unique behaviors and cell types not present in non-tumorigenic lines. We report here that cells from tumorigenic lines and tumors undergo rapid coalescence in 3D, mediated by specific cell types that we have named "facilitators" and "probes." A third cell type, the "dervish", is capable of rapid movement through the gel and does not adhere to it. These cell types have never before been described. Our data suggest that tumorigenesis in vitro is a developmental process involving coalescence facilitated by specialized cells that culminates in large hollow spheres with complex architecture. The unique effects of select monoclonal antibodies on these processes demonstrate the usefulness of the model for analyzing the mechanisms of anti-cancer drugs.

  10. Exact computation of the Voronoi Diagram of spheres in 3D, its topology and its geometric invariants

    DEFF Research Database (Denmark)

    Anton, François; Mioc, Darka; Santos, Marcelo

    2011-01-01

    regrouping all the formal coefficients for each monomial in each polynomial, we get polynomials that are invariants for the given problem. We rewrite the original system by replacing the invariant polynomials by new formal coefficients. We repeat the process until all the algebraic relationships (syzygies...... treatment of the exact computation with geometrical invariants of the Delaunay graph and the Voronoi diagram of spheres. Starting from the system of equations defining the zero-dimensional algebraic set of the problem, we are following Wu’s algorithm to transform the initial system into an equivalent Wu...... characteristic (triangular) set. In the corresponding system of algebraic equations, in each polynomial (except the first one), the variable with higher order from the preceding polynomial has been eliminated (by pseudo-remainder computations) and the last polynomial is a polynomial of a single variable. By...

  11. 3-D components of a biological neural network visualized in computer generated imagery. II - Macular neural network organization

    Science.gov (United States)

    Ross, Muriel D.; Meyer, Glenn; Lam, Tony; Cutler, Lynn; Vaziri, Parshaw

    1990-01-01

    Computer-assisted reconstructions of small parts of the macular neural network show how the nerve terminals and receptive fields are organized in 3-dimensional space. This biological neural network is anatomically organized for parallel distributed processing of information. Processing appears to be more complex than in computer-based neural network, because spatiotemporal factors figure into synaptic weighting. Serial reconstruction data show anatomical arrangements which suggest that (1) assemblies of cells analyze and distribute information with inbuilt redundancy, to improve reliability; (2) feedforward/feedback loops provide the capacity for presynaptic modulation of output during processing; (3) constrained randomness in connectivities contributes to adaptability; and (4) local variations in network complexity permit differing analyses of incoming signals to take place simultaneously. The last inference suggests that there may be segregation of information flow to central stations subserving particular functions.

  12. An adaptive grid method for computing the high speed 3D viscous flow about a re-entry vehicle

    Science.gov (United States)

    Bockelie, Michael J.; Smith, Robert E.

    1992-01-01

    An algebraic solution adaptive grid generation method that allows adapting the grid in all three coordinate directions is presented. Techniques are described that maintain the integrity of the original vehicle definition for grid point movement on the vehicle surface and that avoid grid cross over in the boundary layer portion of the grid lying next to the vehicle surface. The adaptive method is tested by computing the Mach 6 hypersonic three dimensional viscous flow about a proposed Martian entry vehicle.

  13. Comparative evaluation of the accuracy of linear measurements between cone beam computed tomography and 3D microtomography

    OpenAIRE

    Francesca Mangione; Deborah Meleo; Marco Talocco; Raffaella Pecci; Luciano Pacifici; Rossella Bedini

    2013-01-01

    OBJECTIVE: The aim of this study was to evaluate the influence of artifacts on the accuracy of linear measurements estimated with a common cone beam computed tomography (CBCT) system used in dental clinical practice, by comparing it with microCT system as standard reference. MATERIALS AND METHODS: Ten bovine bone cylindrical samples containing one implant each, able to provide both points of reference and image quality degradation, have been scanned by CBCT and microCT systems. Thanks to the ...

  14. Multiscale paradigms in integrated computational materials science and engineering materials theory, modeling, and simulation for predictive design

    CERN Document Server

    Runge, Keith; Muralidharan, Krishna

    2016-01-01

    This book presents cutting-edge concepts, paradigms, and research highlights in the field of computational materials science and engineering, and provides a fresh, up-to-date perspective on solving present and future materials challenges. The chapters are written by not only pioneers in the fields of computational materials chemistry and materials science, but also experts in multi-scale modeling and simulation as applied to materials engineering. Pedagogical introductions to the different topics and continuity between the chapters are provided to ensure the appeal to a broad audience and to address the applicability of integrated computational materials science and engineering for solving real-world problems.

  15. A Multiscale Bidirectional Coupling Framework

    Energy Technology Data Exchange (ETDEWEB)

    Kabilan, Senthil; Kuprat, Andrew P.; Hlastala, Michael P.; Corley, Richard A.; Einstein, Daniel R.

    2011-12-01

    The lung is geometrically articulated across multiple scales from the trachea to the alveoli. A major computational challenge is to tightly link ODEs that describe lower scales to 3D finite element or finite volume models of airway mechanics using iterative communication between scales. In this study, we developed a novel multiscale computational framework for bidirectionally coupling 3D CFD models and systems of lower order ODEs. To validate the coupling framework, a four and eight generation Weibel lung model was constructed. For the coupled CFD-ODE simulations, the lung models were truncated at different generations and a RL circuit represented the truncated portion. The flow characteristics from the coupled models were compared to untruncated full 3D CFD models at peak inhalation and peak exhalation. Results showed that at no time or simulation was the difference in mass flux and/or pressure at a given location between uncoupled and coupled models was greater than 2.43%. The flow characteristics at prime locations for the coupled models showed good agreement to uncoupled models. Remarkably, due to reuse of the Krylov subspace, the cost of the ODE coupling is not much greater than uncoupled full 3D-CFD computations with simple prescribed pressure values at the outlets.

  16. Development of a computational program for fuel management in a 3-D, two energy groups nuclear reactor core

    International Nuclear Information System (INIS)

    Full text: A computational program was developed for reactor fuel management in three dimensional Cartesian coordinates using two-group neutron diffusion theory (fast neutron and thermal neutron energy group). Three fuel loading patterns were considered as follow: 1. uniform loading, 2. out-in loading and 3. in-scatter loading. Criticality, peak power distribution and loaded fuel depletion measured in megawatt-day per kilogram (MW d/kg) of uranium were also calculated by the developed program. The results showed that the in-scatter loading pattern gave the best power peaking for fuel management

  17. 3-D components of a biological neural network visualized in computer generated imagery. I - Macular receptive field organization

    Science.gov (United States)

    Ross, Muriel D.; Cutler, Lynn; Meyer, Glenn; Lam, Tony; Vaziri, Parshaw

    1990-01-01

    Computer-assisted, 3-dimensional reconstructions of macular receptive fields and of their linkages into a neural network have revealed new information about macular functional organization. Both type I and type II hair cells are included in the receptive fields. The fields are rounded, oblong, or elongated, but gradations between categories are common. Cell polarizations are divergent. Morphologically, each calyx of oblong and elongated fields appears to be an information processing site. Intrinsic modulation of information processing is extensive and varies with the kind of field. Each reconstructed field differs in detail from every other, suggesting that an element of randomness is introduced developmentally and contributes to endorgan adaptability.

  18. 3D printing in dentistry.

    Science.gov (United States)

    Dawood, A; Marti Marti, B; Sauret-Jackson, V; Darwood, A

    2015-12-01

    3D printing has been hailed as a disruptive technology which will change manufacturing. Used in aerospace, defence, art and design, 3D printing is becoming a subject of great interest in surgery. The technology has a particular resonance with dentistry, and with advances in 3D imaging and modelling technologies such as cone beam computed tomography and intraoral scanning, and with the relatively long history of the use of CAD CAM technologies in dentistry, it will become of increasing importance. Uses of 3D printing include the production of drill guides for dental implants, the production of physical models for prosthodontics, orthodontics and surgery, the manufacture of dental, craniomaxillofacial and orthopaedic implants, and the fabrication of copings and frameworks for implant and dental restorations. This paper reviews the types of 3D printing technologies available and their various applications in dentistry and in maxillofacial surgery. PMID:26657435

  19. 3D printing in dentistry.

    Science.gov (United States)

    Dawood, A; Marti Marti, B; Sauret-Jackson, V; Darwood, A

    2015-12-01

    3D printing has been hailed as a disruptive technology which will change manufacturing. Used in aerospace, defence, art and design, 3D printing is becoming a subject of great interest in surgery. The technology has a particular resonance with dentistry, and with advances in 3D imaging and modelling technologies such as cone beam computed tomography and intraoral scanning, and with the relatively long history of the use of CAD CAM technologies in dentistry, it will become of increasing importance. Uses of 3D printing include the production of drill guides for dental implants, the production of physical models for prosthodontics, orthodontics and surgery, the manufacture of dental, craniomaxillofacial and orthopaedic implants, and the fabrication of copings and frameworks for implant and dental restorations. This paper reviews the types of 3D printing technologies available and their various applications in dentistry and in maxillofacial surgery.

  20. A Multiscale Computational Model of the Response of Swine Epidermis After Acute Irradiation

    Science.gov (United States)

    Hu, Shaowen; Cucinotta, Francis A.

    2012-01-01

    Radiation exposure from Solar Particle Events can lead to very high skin dose for astronauts on exploration missions outside the protection of the Earth s magnetic field [1]. Assessing the detrimental effects to human skin under such adverse conditions could be predicted by conducting territorial experiments on animal models. In this study we apply a computational approach to simulate the experimental data of the radiation response of swine epidermis, which is closely similar to human epidermis [2]. Incorporating experimentally measured histological and cell kinetic parameters into a multiscale tissue modeling framework, we obtain results of population kinetics and proliferation index comparable to unirradiated and acutely irradiated swine experiments [3]. It is noted the basal cell doubling time is 10 to 16 days in the intact population, but drops to 13.6 hr in the regenerating populations surviving irradiation. This complex 30-fold variation is proposed to be attributed to the shortening of the G1 phase duration. We investigate this radiation induced effect by considering at the sub-cellular level the expression and signaling of TGF-beta, as it is recognized as a key regulatory factor of tissue formation and wound healing [4]. This integrated model will allow us to test the validity of various basic biological rules at the cellular level and sub-cellular mechanisms by qualitatively comparing simulation results with published research, and should lead to a fuller understanding of the pathophysiological effects of ionizing radiation on the skin.

  1. A Multi-Scale Computational Study on the Mechanism of Streptococcus pneumoniae Nicotinamidase (SpNic

    Directory of Open Access Journals (Sweden)

    Bogdan F. Ion

    2014-09-01

    Full Text Available Nicotinamidase (Nic is a key zinc-dependent enzyme in NAD metabolism that catalyzes the hydrolysis of nicotinamide to give nicotinic acid. A multi-scale computational approach has been used to investigate the catalytic mechanism, substrate binding and roles of active site residues of Nic from Streptococcus pneumoniae (SpNic. In particular, density functional theory (DFT, molecular dynamics (MD and ONIOM quantum mechanics/molecular mechanics (QM/MM methods have been employed. The overall mechanism occurs in two stages: (i formation of a thioester enzyme-intermediate (IC2 and (ii hydrolysis of the thioester bond to give the products. The polar protein environment has a significant effect in stabilizing reaction intermediates and in particular transition states. As a result, both stages effectively occur in one step with Stage 1, formation of IC2, being rate limiting barrier with a cost of 53.5 kJ•mol−1 with respect to the reactant complex, RC. The effects of dispersion interactions on the overall mechanism were also considered but were generally calculated to have less significant effects with the overall mechanism being unchanged. In addition, the active site lysyl (Lys103 is concluded to likely play a role in stabilizing the thiolate of Cys136 during the reaction.

  2. Computational multiscale toxicodynamic modeling of silver and carbon nanoparticle effects on mouse lung function.

    Directory of Open Access Journals (Sweden)

    Dwaipayan Mukherjee

    Full Text Available A computational, multiscale toxicodynamic model has been developed to quantify and predict pulmonary effects due to uptake of engineered nanomaterials (ENMs in mice. The model consists of a collection of coupled toxicodynamic modules, that were independently developed and tested using information obtained from the literature. The modules were developed to describe the dynamics of tissue with explicit focus on the cells and the surfactant chemicals that regulate the process of breathing, as well as the response of the pulmonary system to xenobiotics. Alveolar type I and type II cells, and alveolar macrophages were included in the model, along with surfactant phospholipids and surfactant proteins, to account for processes occurring at multiple biological scales, coupling cellular and surfactant dynamics affected by nanoparticle exposure, and linking the effects to tissue-level lung function changes. Nanoparticle properties such as size, surface chemistry, and zeta potential were explicitly considered in modeling the interactions of these particles with biological media. The model predictions were compared with in vivo lung function response measurements in mice and analysis of mice lung lavage fluid following exposures to silver and carbon nanoparticles. The predictions were found to follow the trends of observed changes in mouse surfactant composition over 7 days post dosing, and are in good agreement with the observed changes in mouse lung function over the same period of time.

  3. Quantitative comparison of hemodynamics in simulated and 3D angiography models of cerebral aneurysms by use of computational fluid dynamics.

    Science.gov (United States)

    Saho, Tatsunori; Onishi, Hideo

    2015-07-01

    In this study, we evaluated hemodynamics using simulated models and determined how cerebral aneurysms develop in simulated and patient-specific models based on medical images. Computational fluid dynamics (CFD) was analyzed by use of OpenFOAM software. Flow velocity, stream line, and wall shear stress (WSS) were evaluated in a simulated model aneurysm with known geometry and in a three-dimensional angiographic model. The ratio of WSS at the aneurysm compared with that at the basilar artery was 1:10 in simulated model aneurysms with a diameter of 10 mm and 1:18 in the angiographic model, indicating similar tendencies. Vortex flow occurred in both model aneurysms, and the WSS decreased in larger model aneurysms. The angiographic model provided accurate CFD information, and the tendencies of simulated and angiographic models were similar. These findings indicate that hemodynamic effects are involved in the development of aneurysms. PMID:25911446

  4. Development of microgravity, full body functional reach envelope using 3-D computer graphic models and virtual reality technology

    Science.gov (United States)

    Lindsey, Patricia F.

    1994-01-01

    In microgravity conditions mobility is greatly enhanced and body stability is difficult to achieve. Because of these difficulties, optimum placement and accessibility of objects and controls can be critical to required tasks on board shuttle flights or on the proposed space station. Anthropometric measurement of the maximum reach of occupants of a microgravity environment provide knowledge about maximum functional placement for tasking situations. Calculations for a full body, functional reach envelope for microgravity environments are imperative. To this end, three dimensional computer modeled human figures, providing a method of anthropometric measurement, were used to locate the data points that define the full body, functional reach envelope. Virtual reality technology was utilized to enable an occupant of the microgravity environment to experience movement within the reach envelope while immersed in a simulated microgravity environment.

  5. Role of volume rendered 3-D computed tomography in conservative management of trauma-related thoracic injuries.

    LENUS (Irish Health Repository)

    OʼLeary, Donal Peter

    2012-09-01

    Pneumatic nail guns are a tool used commonly in the construction industry and are widely available. Accidental injuries from nail guns are common, and several cases of suicide using a nail gun have been reported. Computed tomographic (CT) imaging, together with echocardiography, has been shown to be the gold standard for investigation of these cases. We present a case of a 55-year-old man who presented to the accident and emergency unit of a community hospital following an accidental pneumatic nail gun injury to his thorax. Volume-rendered CT of the thorax allowed an accurate assessment of the thoracic injuries sustained by this patient. As there was no evidence of any acute life-threatening injury, a sternotomy was avoided and the patient was observed closely until discharge. In conclusion, volume-rendered 3-dimensional CT can greatly help in the decision to avoid an unnecessary sternotomy in patients with a thoracic nail gun injury.

  6. Computer-assisted three-dimensional surgical planing and simulation. 3D soft tissue planning and prediction.

    Science.gov (United States)

    Xia, J; Samman, N; Yeung, R W; Wang, D; Shen, S G; Ip, H H; Tideman, H

    2000-08-01

    The purpose of this paper is to report a new technique for three-dimensional facial soft-tissue-change prediction after simulated orthognathic surgical planning. A scheme for soft tissue deformation, "Computer-assisted three-dimensional virtual reality soft tissue planning and prediction for orthognathic surgery (CASP)", is presented. The surgical planning was based on three-dimensional reconstructed CT visualization. Soft tissue changes were predicted by two newly devised algorithms: Surface Normal-based Model Deformation Algorithm and Ray Projection-based Model Deformation Algorithm. A three-dimensional color facial texture-mapping technique was also used for generating the color photo-realistic facial model. As a final result, a predicted and simulated patient's color facial model can be visualized from arbitrary viewing points.

  7. Confirmatory analysis of the AP1000 passive residual heat removal heat exchanger with 3-D computational fluid dynamic analysis

    International Nuclear Information System (INIS)

    The AP1000 is an 1100 MWe advanced nuclear power plant that uses passive safety features to enhance plant safety and to provide significant and measurable improvements in plant simplification, reliability, investment protection and plant costs. The AP1000 received final design approval from the US-NRC in 2004. The AP1000 design is based on the AP600 design that received final design approval in 1999. Wherever possible, the AP1000 plant configuration and layout was kept the same as AP600 to take advantage of the maturity of the design and to minimize new design efforts. As a result, the two-loop configuration was maintained for AP1000, and the containment vessel diameter was kept the same. It was determined that this significant power up-rate was well within the capability of the passive safety features, and that the safety margins for AP1000 were greater than those of operating PWRs. A key feature of the passive core cooling system is the passive residual heat removal heat exchanger (PRHR HX) that provides decay heat removal for postulated LOCA and non-LOCA events. The PRHR HX is a C-tube heat exchanger located in the in-containment refueling water storage tank (IRWST) above the core promoting natural circulation heat removal between the reactor cooling system and the tank. Component testing was performed for the AP600 PRHR HX to determine the heat transfer characteristics and to develop correlations to be used for the AP1000 safety analysis codes. The data from these tests were confirmed by subsequent integral tests at three separate facilities including the ROSA facility in Japan. Owing to the importance of this component, an independent analysis has been performed using the ATHOS-based computational fluid dynamics computer code PRHRCFD. Two separate models of the PRHR HX and IRWST have been developed representing the ROSA test geometry and the AP1000 plant geometry. Confirmation of the ROSA test results were used to validate PRHRCFD, and the AP1000 plant model

  8. Creating PWMs of transcription factors using 3D structure-based computation of protein-DNA free binding energies

    Directory of Open Access Journals (Sweden)

    Stegmaier Philip

    2010-05-01

    Full Text Available Abstract Background Knowledge of transcription factor-DNA binding patterns is crucial for understanding gene transcription. Numerous DNA-binding proteins are annotated as transcription factors in the literature, however, for many of them the corresponding DNA-binding motifs remain uncharacterized. Results The position weight matrices (PWMs of transcription factors from different structural classes have been determined using a knowledge-based statistical potential. The scoring function calibrated against crystallographic data on protein-DNA contacts recovered PWMs of various members of widely studied transcription factor families such as p53 and NF-κB. Where it was possible, extensive comparison to experimental binding affinity data and other physical models was made. Although the p50p50, p50RelB, and p50p65 dimers belong to the same family, particular differences in their PWMs were detected, thereby suggesting possibly different in vivo binding modes. The PWMs of p63 and p73 were computed on the basis of homology modeling and their performance was studied using upstream sequences of 85 p53/p73-regulated human genes. Interestingly, about half of the p63 and p73 hits reported by the Match algorithm in the altogether 126 promoters lay more than 2 kb upstream of the corresponding transcription start sites, which deviates from the common assumption that most regulatory sites are located more proximal to the TSS. The fact that in most of the cases the binding sites of p63 and p73 did not overlap with the p53 sites suggests that p63 and p73 could influence the p53 transcriptional activity cooperatively. The newly computed p50p50 PWM recovered 5 more experimental binding sites than the corresponding TRANSFAC matrix, while both PWMs showed comparable receiver operator characteristics. Conclusions A novel algorithm was developed to calculate position weight matrices from protein-DNA complex structures. The proposed algorithm was extensively validated

  9. Color 3D Reverse Engineering

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This paper presents a principle and a method of col or 3D laser scanning measurement. Based on the fundamental monochrome 3D measureme nt study, color information capture, color texture mapping, coordinate computati on and other techniques are performed to achieve color 3D measurement. The syste m is designed and composed of a line laser light emitter, one color CCD camera, a motor-driven rotary filter, a circuit card and a computer. Two steps in captu ring object's images in the measurement process: Firs...

  10. Virtual forensic entomology: improving estimates of minimum post-mortem interval with 3D micro-computed tomography.

    Science.gov (United States)

    Richards, Cameron S; Simonsen, Thomas J; Abel, Richard L; Hall, Martin J R; Schwyn, Daniel A; Wicklein, Martina

    2012-07-10

    We demonstrate how micro-computed tomography (micro-CT) can be a powerful tool for describing internal and external morphological changes in Calliphora vicina (Diptera: Calliphoridae) during metamorphosis. Pupae were sampled during the 1st, 2nd, 3rd and 4th quarter of development after the onset of pupariation at 23 °C, and placed directly into 80% ethanol for preservation. In order to find the optimal contrast, four batches of pupae were treated differently: batch one was stained in 0.5M aqueous iodine for 1 day; two for 7 days; three was tagged with a radiopaque dye; four was left unstained (control). Pupae stained for 7d in iodine resulted in the best contrast micro-CT scans. The scans were of sufficiently high spatial resolution (17.2 μm) to visualise the internal morphology of developing pharate adults at all four ages. A combination of external and internal morphological characters was shown to have the potential to estimate the age of blowfly pupae with a higher degree of accuracy and precision than using external morphological characters alone. Age specific developmental characters are described. The technique could be used as a measure to estimate a minimum post-mortem interval in cases of suspicious death where pupae are the oldest stages of insect evidence collected.

  11. Clinical feasibility of 3D automated coronary atherosclerotic plaque quantification algorithm on coronary computed tomography angiography: Comparison with intravascular ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hyung-Bok [Yonsei University Health System, Yonsei-Cedar Sinai Integrative Cardiovascular Imaging Research Center, Seoul (Korea, Republic of); Myongji Hospital, Division of Cardiology, Cardiovascular Center, Goyang (Korea, Republic of); Lee, Byoung Kwon [Yonsei University College of Medicine, Division of Cardiology, Gangnam Severance Hospital, Seoul (Korea, Republic of); Shin, Sanghoon [Yonsei University Health System, Yonsei-Cedar Sinai Integrative Cardiovascular Imaging Research Center, Seoul (Korea, Republic of); National Health Insurance Corporation Ilsan Hospital, Division of Cardiology, Goyang (Korea, Republic of); Heo, Ran; Chang, Hyuk-Jae; Chung, Namsik [Yonsei University Health System, Yonsei-Cedar Sinai Integrative Cardiovascular Imaging Research Center, Seoul (Korea, Republic of); Yonsei University Health System, Division of Cardiology, Severance Cardiovascular Hospital, Seoul (Korea, Republic of); Arsanjani, Reza [Cedars-Sinai Medical Center, Departments of Imaging and Medicine, Cedars-Sinai Heart Institute, Los Angeles, CA (United States); Kitslaar, Pieter H. [Leiden University Medical Center, Department of Radiology, Division of Image Processing, Leiden (Netherlands); Medis medical Imaging Systems B.V., Leiden (Netherlands); Broersen, Alexander; Dijkstra, Jouke [Leiden University Medical Center, Department of Radiology, Division of Image Processing, Leiden (Netherlands); Ahn, Sung Gyun [Yonsei University Wonju Severance Christian Hospital, Division of Cardiology, Wonju (Korea, Republic of); Min, James K. [New York-Presbyterian Hospital, Institute for Cardiovascular Imaging, Weill-Cornell Medical College, New York, NY (United States); Hong, Myeong-Ki; Jang, Yangsoo [Yonsei University Health System, Division of Cardiology, Severance Cardiovascular Hospital, Seoul (Korea, Republic of)

    2015-10-15

    To evaluate the diagnostic performance of automated coronary atherosclerotic plaque quantification (QCT) by different users (expert/non-expert/automatic). One hundred fifty coronary artery segments from 142 patients who underwent coronary computed tomography angiography (CCTA) and intravascular ultrasound (IVUS) were analyzed. Minimal lumen area (MLA), maximal lumen area stenosis percentage (%AS), mean plaque burden percentage (%PB), and plaque volume were measured semi-automatically by expert, non-expert, and fully automatic QCT analyses, and then compared to IVUS. Between IVUS and expert QCT analysis, the correlation coefficients (r) for the MLA, %AS, %PB, and plaque volume were excellent: 0.89 (p < 0.001), 0.84 (p < 0.001), 0.91 (p < 0.001), and 0.94 (p < 0.001), respectively. There were no significant differences in the mean parameters (all p values >0.05) except %AS (p = 0.01). The automatic QCT analysis showed comparable performance to non-expert QCT analysis, showing correlation coefficients (r) of the MLA (0.80 vs. 0.82), %AS (0.82 vs. 0.80), %PB (0.84 vs. 0.73), and plaque volume (0.84 vs. 0.79) when they were compared to IVUS, respectively. Fully automatic QCT analysis showed clinical utility compared with IVUS, as well as a compelling performance when compared with semiautomatic analyses. (orig.)

  12. 3D Computation of Hydrogen-Fueled Combustion around Turbine Blade-Effect of Arrangement of Injector Holes -

    Institute of Scientific and Technical Information of China (English)

    Makoto YAMAMOTO; Junichi IKEDA; Kazuaki INABA

    2006-01-01

    Recently, a number of environmental problems caused from fossil fuel combustion have been focused on. In addition, with the eventual depletion of fossil energy resources, hydrogen gas is expected to be an alternative energy resource in the near future. It is characterized by high energy per unit weight, high reaction rate, wide range of flammability and the low emission property. On the other hand, many researches have been underway in several countries to improve a propulsion system for an advanced aircraft. The system is required to have higher power, lighter weight and lower emissions than existing ones. In such a future propulsion system, hydrogen gas would be one of the promising fuels for realizing the requirements. Considering these backgrounds, our group has proposed a new cycle concept for hydrogen-fueled aircraft propulsion system. In the present study, we perform 3dimensional computations of turbulent flow fields with hydrogen-fueled combustion around a turbine blade. The main objective is to clarify the influence of arrangement of hydrogen injector holes. Changing the chordwise and spanwise spacings of the holes, the 3 dimensional nature of the flow and thermal fields is numerically studied.

  13. Comparative evaluation of the accuracy of linear measurements between cone beam computed tomography and 3D microtomography

    Directory of Open Access Journals (Sweden)

    Francesca Mangione

    2013-09-01

    Full Text Available OBJECTIVE: The aim of this study was to evaluate the influence of artifacts on the accuracy of linear measurements estimated with a common cone beam computed tomography (CBCT system used in dental clinical practice, by comparing it with microCT system as standard reference. MATERIALS AND METHODS: Ten bovine bone cylindrical samples containing one implant each, able to provide both points of reference and image quality degradation, have been scanned by CBCT and microCT systems. Thanks to the software of the two systems, for each cylindrical sample, two diameters taken at different levels, by using implants different points as references, have been measured. Results have been analyzed by ANOVA and a significant statistically difference has been found. RESULTS AND DISCUSSION: Due to the obtained results, in this work it is possible to say that the measurements made with the two different instruments are still not statistically comparable, although in some samples were obtained similar performances and therefore not statistically significant. CONCLUSION: With the improvement of the hardware and software of CBCT systems, in the near future the two instruments will be able to provide similar performances.

  14. EUROPEANA AND 3D

    Directory of Open Access Journals (Sweden)

    D. Pletinckx

    2012-09-01

    Full Text Available The current 3D hype creates a lot of interest in 3D. People go to 3D movies, but are we ready to use 3D in our homes, in our offices, in our communication? Are we ready to deliver real 3D to a general public and use interactive 3D in a meaningful way to enjoy, learn, communicate? The CARARE project is realising this for the moment in the domain of monuments and archaeology, so that real 3D of archaeological sites and European monuments will be available to the general public by 2012. There are several aspects to this endeavour. First of all is the technical aspect of flawlessly delivering 3D content over all platforms and operating systems, without installing software. We have currently a working solution in PDF, but HTML5 will probably be the future. Secondly, there is still little knowledge on how to create 3D learning objects, 3D tourist information or 3D scholarly communication. We are still in a prototype phase when it comes to integrate 3D objects in physical or virtual museums. Nevertheless, Europeana has a tremendous potential as a multi-facetted virtual museum. Finally, 3D has a large potential to act as a hub of information, linking to related 2D imagery, texts, video, sound. We describe how to create such rich, explorable 3D objects that can be used intuitively by the generic Europeana user and what metadata is needed to support the semantic linking.

  15. Automotive Underhood Thermal Management Analysis Using 3-D Coupled Thermal-Hydrodynamic Computer Models: Thermal Radiation Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Pannala, S; D' Azevedo, E; Zacharia, T

    2002-02-26

    The goal of the radiation modeling effort was to develop and implement a radiation algorithm that is fast and accurate for the underhood environment. As part of this CRADA, a net-radiation model was chosen to simulate radiative heat transfer in an underhood of a car. The assumptions (diffuse-gray and uniform radiative properties in each element) reduce the problem tremendously and all the view factors for radiation thermal calculations can be calculated once and for all at the beginning of the simulation. The cost for online integration of heat exchanges due to radiation is found to be less than 15% of the baseline CHAD code and thus very manageable. The off-line view factor calculation is constructed to be very modular and has been completely integrated to read CHAD grid files and the output from this code can be read into the latest version of CHAD. Further integration has to be performed to accomplish the same with STAR-CD. The main outcome of this effort is to obtain a highly scalable and portable simulation capability to model view factors for underhood environment (for e.g. a view factor calculation which took 14 hours on a single processor only took 14 minutes on 64 processors). The code has also been validated using a simple test case where analytical solutions are available. This simulation capability gives underhood designers in the automotive companies the ability to account for thermal radiation - which usually is critical in the underhood environment and also turns out to be one of the most computationally expensive components of underhood simulations. This report starts off with the original work plan as elucidated in the proposal in section B. This is followed by Technical work plan to accomplish the goals of the project in section C. In section D, background to the current work is provided with references to the previous efforts this project leverages on. The results are discussed in section 1E. This report ends with conclusions and future scope of

  16. Solid works 3D

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Cheol Yeong

    2004-02-15

    This book explains modeling of solid works 3D and application of 3D CAD/CAM. The contents of this book are outline of modeling such as CAD and 2D and 3D, solid works composition, method of sketch, writing measurement fixing, selecting projection, choosing condition of restriction, practice of sketch, making parts, reforming parts, modeling 3D, revising 3D modeling, using pattern function, modeling necessaries, assembling, floor plan, 3D modeling method, practice floor plans for industrial engineer data aided manufacturing, processing of CAD/CAM interface.

  17. Solid works 3D

    International Nuclear Information System (INIS)

    This book explains modeling of solid works 3D and application of 3D CAD/CAM. The contents of this book are outline of modeling such as CAD and 2D and 3D, solid works composition, method of sketch, writing measurement fixing, selecting projection, choosing condition of restriction, practice of sketch, making parts, reforming parts, modeling 3D, revising 3D modeling, using pattern function, modeling necessaries, assembling, floor plan, 3D modeling method, practice floor plans for industrial engineer data aided manufacturing, processing of CAD/CAM interface.

  18. 一种三维物体相息图的迭代计算方法%An Iterative Algorithm for Kinoform Computation of 3D Object

    Institute of Scientific and Technical Information of China (English)

    裴闯; 蒋晓瑜; 王加; 张鹏炜

    2013-01-01

    在传统迭代傅里叶变换算法的基础上,提出了一种计算三维物体相息图的新方法.基于层析法将三维物体的多个分层物面作为衍射再现图像,在一个输入面(相息图)和多个输出面(再现像)之间进行迭代.通过在傅里叶迭代运算中引入距离相位因子,表示物体不同物面的深度,体现了物体的三维特征.实验结果证明了本文算法良好的收敛特性和再现性能.最后,分析了物面数量和间距对全息再现质量的影响,利用液晶空间光调制器采用时分复用的方法还原了三维物体的多个物面.%A novel method for computing kinoform of 3D object based on traditional iterative Fourier transform algorithm is described. The method divides three-dimensional object into many object planes by tomographic technique and treat every object plane as a target image, then iterative computation is carried out between one input plane(kinoform) and several output planes (reconstruction images). A space phase factor is added into iterative process to represent depth characters of 3D object. The experimental result shows that this algorithm computational and convergent velocity is fast. At last, the influences of object planes number and distance to reconstruction quality of kinoform are analyzed, and time-division multiplexing technique is used to reconstruct several object planes based on spatial light modulator.

  19. Increasing the impact of medical image computing using community-based open-access hackathons: The NA-MIC and 3D Slicer experience.

    Science.gov (United States)

    Kapur, Tina; Pieper, Steve; Fedorov, Andriy; Fillion-Robin, J-C; Halle, Michael; O'Donnell, Lauren; Lasso, Andras; Ungi, Tamas; Pinter, Csaba; Finet, Julien; Pujol, Sonia; Jagadeesan, Jayender; Tokuda, Junichi; Norton, Isaiah; Estepar, Raul San Jose; Gering, David; Aerts, Hugo J W L; Jakab, Marianna; Hata, Nobuhiko; Ibanez, Luiz; Blezek, Daniel; Miller, Jim; Aylward, Stephen; Grimson, W Eric L; Fichtinger, Gabor; Wells, William M; Lorensen, William E; Schroeder, Will; Kikinis, Ron

    2016-10-01

    The National Alliance for Medical Image Computing (NA-MIC) was launched in 2004 with the goal of investigating and developing an open source software infrastructure for the extraction of information and knowledge from medical images using computational methods. Several leading research and engineering groups participated in this effort that was funded by the US National Institutes of Health through a variety of infrastructure grants. This effort transformed 3D Slicer from an internal, Boston-based, academic research software application into a professionally maintained, robust, open source platform with an international leadership and developer and user communities. Critical improvements to the widely used underlying open source libraries and tools-VTK, ITK, CMake, CDash, DCMTK-were an additional consequence of this effort. This project has contributed to close to a thousand peer-reviewed publications and a growing portfolio of US and international funded efforts expanding the use of these tools in new medical computing applications every year. In this editorial, we discuss what we believe are gaps in the way medical image computing is pursued today; how a well-executed research platform can enable discovery, innovation and reproducible science ("Open Science"); and how our quest to build such a software platform has evolved into a productive and rewarding social engineering exercise in building an open-access community with a shared vision.

  20. An Efficient Framework For Fast Computer Aided Design of Microwave Circuits Based on the Higher-Order 3D Finite-Element Method

    Directory of Open Access Journals (Sweden)

    A. Lamecki

    2014-12-01

    Full Text Available In this paper, an efficient computational framework for the full-wave design by optimization of complex microwave passive devices, such as antennas, filters, and multiplexers, is described. The framework consists of a computational engine, a 3D object modeler, and a graphical user interface. The computational engine, which is based on a finite element method with curvilinear higher-order tetrahedral elements, is coupled with built-in or external gradient-based optimization procedures. For speed, a model order reduction technique is used and the gradient computation is achieved by perturbation with geometry deformation, processed on the level of the individual mesh nodes. To maximize performance, the framework is targeted to multicore CPU architectures and its extended version can also use multiple GPUs. To illustrate the accuracy and high efficiency of the framework, we provide examples of simulations of a dielectric resonator antenna and full-wave design by optimization of two diplexers involving tens of unknowns, and show that the design can be completed within the duration of a few simulations using industry-standard FEM solvers. The accuracy of the design is confirmed by measurements.

  1. Increasing the impact of medical image computing using community-based open-access hackathons: The NA-MIC and 3D Slicer experience.

    Science.gov (United States)

    Kapur, Tina; Pieper, Steve; Fedorov, Andriy; Fillion-Robin, J-C; Halle, Michael; O'Donnell, Lauren; Lasso, Andras; Ungi, Tamas; Pinter, Csaba; Finet, Julien; Pujol, Sonia; Jagadeesan, Jayender; Tokuda, Junichi; Norton, Isaiah; Estepar, Raul San Jose; Gering, David; Aerts, Hugo J W L; Jakab, Marianna; Hata, Nobuhiko; Ibanez, Luiz; Blezek, Daniel; Miller, Jim; Aylward, Stephen; Grimson, W Eric L; Fichtinger, Gabor; Wells, William M; Lorensen, William E; Schroeder, Will; Kikinis, Ron

    2016-10-01

    The National Alliance for Medical Image Computing (NA-MIC) was launched in 2004 with the goal of investigating and developing an open source software infrastructure for the extraction of information and knowledge from medical images using computational methods. Several leading research and engineering groups participated in this effort that was funded by the US National Institutes of Health through a variety of infrastructure grants. This effort transformed 3D Slicer from an internal, Boston-based, academic research software application into a professionally maintained, robust, open source platform with an international leadership and developer and user communities. Critical improvements to the widely used underlying open source libraries and tools-VTK, ITK, CMake, CDash, DCMTK-were an additional consequence of this effort. This project has contributed to close to a thousand peer-reviewed publications and a growing portfolio of US and international funded efforts expanding the use of these tools in new medical computing applications every year. In this editorial, we discuss what we believe are gaps in the way medical image computing is pursued today; how a well-executed research platform can enable discovery, innovation and reproducible science ("Open Science"); and how our quest to build such a software platform has evolved into a productive and rewarding social engineering exercise in building an open-access community with a shared vision. PMID:27498015

  2. COMPUTER MODELING IN DEFORM-3D FOR ANALYSIS OF PLASTIC FLOW IN HIGH-SPEED HOT EXTRUSION OF BIMETALLIC FORMATIVE PARTS OF DIE TOOLING

    Directory of Open Access Journals (Sweden)

    I. V. Kachanov

    2015-01-01

    Full Text Available The modern development of industrial production is closely connected with the use of science-based and high technologies to ensure competitiveness of the manufactured products on the world market. There is also much tension around an energy- and resource saving problem which can be solved while introducing new technological processes and  creation of new materials that provide productivity increase through automation and improvement of tool life. Development and implementation of such technologies are rather often considered as time-consuming processes  which are connected with complex calculations and experimental investigations. Implementation of a simulation modelling for materials processing using modern software products serves an alternative to experimental and theoretical methods of research.The aim of this paper is to compare experimental results while obtaining bimetallic samples of a forming tool through the method of speed hot extrusion and the results obtained with the help of computer simulation using DEFORM-3D package and a finite element method. Comparative analysis of plastic flow of real and model samples has shown that the obtained models provide high-quality and reliable picture of plastic flow during high-speed hot extrusion. Modeling in DEFORM-3D make it possible to eliminate complex calculations and significantly reduce a number of experimental studies while developing new technological processes.

  3. Imaging the Aqueous Humor Outflow Pathway in Human Eyes by Three-dimensional Micro-computed Tomography (3D micro-CT)

    Energy Technology Data Exchange (ETDEWEB)

    C Hann; M Bentley; A Vercnocke; E Ritman; M Fautsch

    2011-12-31

    The site of outflow resistance leading to elevated intraocular pressure in primary open-angle glaucoma is believed to be located in the region of Schlemm's canal inner wall endothelium, its basement membrane and the adjacent juxtacanalicular tissue. Evidence also suggests collector channels and intrascleral vessels may have a role in intraocular pressure in both normal and glaucoma eyes. Traditional imaging modalities limit the ability to view both proximal and distal portions of the trabecular outflow pathway as a single unit. In this study, we examined the effectiveness of three-dimensional micro-computed tomography (3D micro-CT) as a potential method to view the trabecular outflow pathway. Two normal human eyes were used: one immersion fixed in 4% paraformaldehyde and one with anterior chamber perfusion at 10 mmHg followed by perfusion fixation in 4% paraformaldehyde/2% glutaraldehyde. Both eyes were postfixed in 1% osmium tetroxide and scanned with 3D micro-CT at 2 {mu}m or 5 {mu}m voxel resolution. In the immersion fixed eye, 24 collector channels were identified with an average orifice size of 27.5 {+-} 5 {mu}m. In comparison, the perfusion fixed eye had 29 collector channels with a mean orifice size of 40.5 {+-} 13 {mu}m. Collector channels were not evenly dispersed around the circumference of the eye. There was no significant difference in the length of Schlemm's canal in the immersed versus the perfused eye (33.2 versus 35.1 mm). Structures, locations and size measurements identified by 3D micro-CT were confirmed by correlative light microscopy. These findings confirm 3D micro-CT can be used effectively for the non-invasive examination of the trabecular meshwork, Schlemm's canal, collector channels and intrascleral vasculature that comprise the distal outflow pathway. This imaging modality will be useful for non-invasive study of the role of the trabecular outflow pathway as a whole unit.

  4. A task-based parallelism and vectorized approach to 3D Method of Characteristics (MOC) reactor simulation for high performance computing architectures

    Science.gov (United States)

    Tramm, John R.; Gunow, Geoffrey; He, Tim; Smith, Kord S.; Forget, Benoit; Siegel, Andrew R.

    2016-05-01

    In this study we present and analyze a formulation of the 3D Method of Characteristics (MOC) technique applied to the simulation of full core nuclear reactors. Key features of the algorithm include a task-based parallelism model that allows independent MOC tracks to be assigned to threads dynamically, ensuring load balancing, and a wide vectorizable inner loop that takes advantage of modern SIMD computer architectures. The algorithm is implemented in a set of highly optimized proxy applications in order to investigate its performance characteristics on CPU, GPU, and Intel Xeon Phi architectures. Speed, power, and hardware cost efficiencies are compared. Additionally, performance bottlenecks are identified for each architecture in order to determine the prospects for continued scalability of the algorithm on next generation HPC architectures.

  5. Microstructural analysis of TRISO particles using multi-scale X-ray computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Lowe, T., E-mail: tristan.lowe@manchester.ac.uk [Manchester X-ray Imaging Facility, School of Materials, University of Manchester, M13 9PL (United Kingdom); Bradley, R.S. [Manchester X-ray Imaging Facility, School of Materials, University of Manchester, M13 9PL (United Kingdom); Yue, S. [Manchester X-ray Imaging Facility, School of Materials, University of Manchester, M13 9PL (United Kingdom); The Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxfordshire OX11 0FA (United Kingdom); Barii, K. [School of Mechanical Engineering, University of Manchester, M13 9PL (United Kingdom); Gelb, J. [Zeiss Xradia Inc., Pleasanton, CA (United States); Rohbeck, N. [Manchester X-ray Imaging Facility, School of Materials, University of Manchester, M13 9PL (United Kingdom); Turner, J. [School of Mechanical Engineering, University of Manchester, M13 9PL (United Kingdom); Withers, P.J. [Manchester X-ray Imaging Facility, School of Materials, University of Manchester, M13 9PL (United Kingdom); The Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxfordshire OX11 0FA (United Kingdom)

    2015-06-15

    TRISO particles, a composite nuclear fuel built up by ceramic and graphitic layers, have outstanding high temperature resistance. TRISO fuel is the key technology for High Temperature Reactors (HTRs) and the Generation IV Very High Temperature Reactor (VHTR) variant. TRISO offers unparalleled containment of fission products and is extremely robust during accident conditions. An understanding of the thermal performance and mechanical properties of TRISO fuel requires a detailed knowledge of pore sizes, their distribution and interconnectivity. Here 50 nm, nano-, and 1 μm resolution, micro-computed tomography (CT), have been used to quantify non-destructively porosity of a surrogate TRISO particle at the 0.3–10 μm and 3–100 μm scales respectively. This indicates that pore distributions can reliably be measured down to a size approximately 3 times the pixel size which is consistent with the segmentation process. Direct comparison with Scanning Electron Microscopy (SEM) sections indicates that destructive sectioning can introduce significant levels of coarse damage, especially in the pyrolytic carbon layers. Further comparative work is required to identify means of minimizing such damage for SEM studies. Finally since it is non-destructive, multi-scale time-lapse X-ray CT opens the possibility of intermittently tracking the degradation of TRISO structure under thermal cycles or radiation conditions in order to validate models of degradation such as kernel movement. X-ray CT in-situ experimentation of TRISO particles under load and temperature could also be used to understand the internal changes that occur in the particles under accident conditions.

  6. Microstructural analysis of TRISO particles using multi-scale X-ray computed tomography

    Science.gov (United States)

    Lowe, T.; Bradley, R. S.; Yue, S.; Barii, K.; Gelb, J.; Rohbeck, N.; Turner, J.; Withers, P. J.

    2015-06-01

    TRISO particles, a composite nuclear fuel built up by ceramic and graphitic layers, have outstanding high temperature resistance. TRISO fuel is the key technology for High Temperature Reactors (HTRs) and the Generation IV Very High Temperature Reactor (VHTR) variant. TRISO offers unparalleled containment of fission products and is extremely robust during accident conditions. An understanding of the thermal performance and mechanical properties of TRISO fuel requires a detailed knowledge of pore sizes, their distribution and interconnectivity. Here 50 nm, nano-, and 1 μm resolution, micro-computed tomography (CT), have been used to quantify non-destructively porosity of a surrogate TRISO particle at the 0.3-10 μm and 3-100 μm scales respectively. This indicates that pore distributions can reliably be measured down to a size approximately 3 times the pixel size which is consistent with the segmentation process. Direct comparison with Scanning Electron Microscopy (SEM) sections indicates that destructive sectioning can introduce significant levels of coarse damage, especially in the pyrolytic carbon layers. Further comparative work is required to identify means of minimizing such damage for SEM studies. Finally since it is non-destructive, multi-scale time-lapse X-ray CT opens the possibility of intermittently tracking the degradation of TRISO structure under thermal cycles or radiation conditions in order to validate models of degradation such as kernel movement. X-ray CT in-situ experimentation of TRISO particles under load and temperature could also be used to understand the internal changes that occur in the particles under accident conditions.

  7. Multiscale Computer Simulation of Tensile and Compressive Strain in Polymer- Coated Silica Aerogels

    Science.gov (United States)

    Good, Brian

    2009-01-01

    While the low thermal conductivities of silica aerogels have made them of interest to the aerospace community as lightweight thermal insulation, the application of conformal polymer coatings to these gels increases their strength significantly, making them potentially useful as structural materials as well. In this work we perform multiscale computer simulations to investigate the tensile and compressive strain behavior of silica and polymer-coated silica aerogels. Aerogels are made up of clusters of interconnected particles of amorphous silica of less than bulk density. We simulate gel nanostructure using a Diffusion Limited Cluster Aggregation (DLCA) procedure, which produces aggregates that exhibit fractal dimensions similar to those observed in real aerogels. We have previously found that model gels obtained via DLCA exhibited stress-strain curves characteristic of the experimentally observed brittle failure. However, the strain energetics near the expected point of failure were not consistent with such failure. This shortcoming may be due to the fact that the DLCA process produces model gels that are lacking in closed-loop substructures, compared with real gels. Our model gels therefore contain an excess of dangling strands, which tend to unravel under tensile strain, producing non-brittle failure. To address this problem, we have incorporated a modification to the DLCA algorithm that specifically produces closed loops in the model gels. We obtain the strain energetics of interparticle connections via atomistic molecular statics, and abstract the collective energy of the atomic bonds into a Morse potential scaled to describe gel particle interactions. Polymer coatings are similarly described. We apply repeated small uniaxial strains to DLCA clusters, and allow relaxation of the center eighty percent of the cluster between strains. The simulations produce energetics and stress-strain curves for looped and nonlooped clusters, for a variety of densities and

  8. Multiscale approach including microfibril scale to assess elastic constants of cortical bone based on neural network computation and homogenization method.

    Science.gov (United States)

    Barkaoui, Abdelwahed; Chamekh, Abdessalem; Merzouki, Tarek; Hambli, Ridha; Mkaddem, Ali

    2014-03-01

    The complexity and heterogeneity of bone tissue require a multiscale modeling to understand its mechanical behavior and its remodeling mechanisms. In this paper, a novel multiscale hierarchical approach including microfibril scale based on hybrid neural network (NN) computation and homogenization equations was developed to link nanoscopic and macroscopic scales to estimate the elastic properties of human cortical bone. The multiscale model is divided into three main phases: (i) in step 0, the elastic constants of collagen-water and mineral-water composites are calculated by averaging the upper and lower Hill bounds; (ii) in step 1, the elastic properties of the collagen microfibril are computed using a trained NN simulation. Finite element calculation is performed at nanoscopic levels to provide a database to train an in-house NN program; and (iii) in steps 2-10 from fibril to continuum cortical bone tissue, homogenization equations are used to perform the computation at the higher scales. The NN outputs (elastic properties of the microfibril) are used as inputs for the homogenization computation to determine the properties of mineralized collagen fibril. The mechanical and geometrical properties of bone constituents (mineral, collagen, and cross-links) as well as the porosity were taken in consideration. This paper aims to predict analytically the effective elastic constants of cortical bone by modeling its elastic response at these different scales, ranging from the nanostructural to mesostructural levels. Our findings of the lowest scale's output were well integrated with the other higher levels and serve as inputs for the next higher scale modeling. Good agreement was obtained between our predicted results and literature data. PMID:24123969

  9. 3d-3d correspondence revisited

    Science.gov (United States)

    Chung, Hee-Joong; Dimofte, Tudor; Gukov, Sergei; Sułkowski, Piotr

    2016-04-01

    In fivebrane compactifications on 3-manifolds, we point out the importance of all flat connections in the proper definition of the effective 3d {N}=2 theory. The Lagrangians of some theories with the desired properties can be constructed with the help of homological knot invariants that categorify colored Jones polynomials. Higgsing the full 3d theories constructed this way recovers theories found previously by Dimofte-Gaiotto-Gukov. We also consider the cutting and gluing of 3-manifolds along smooth boundaries and the role played by all flat connections in this operation.

  10. 3D false color computed tomography for diagnosis and follow-up of permanent denervated human muscles submitted to home-based Functional Electrical Stimulation

    Directory of Open Access Journals (Sweden)

    Ugo Carraro

    2015-03-01

    Full Text Available This report outlines the use of a customized false-color 3D computed tomography (CT protocol for the imaging of the rectus femoris of spinal cord injury (SCI patients suffering from complete and permanent denervation, as characterized by complete Conus and Cauda Equina syndrome. This muscle imaging method elicits the progression of the syndrome from initial atrophy to eventual degeneration, as well as the extent to which patients' quadriceps could be recovered during four years of home-based functional electrical stimulation (h-b FES. Patients were pre-selected from several European hospitals and functionally tested by, and enrolled in the EU Commission Shared Cost Project RISE (Contract n. QLG5-CT-2001-02191 at the Department of Physical Medicine, Wilhelminenspital, Vienna, Austria. Denervated muscles were electrically stimulated using a custom-designed stimulator, large surface electrodes, and customized progressive stimulation settings. Spiral CT images and specialized computational tools were used to isolate the rectus femoris muscle and produce 3D and 2D reconstructions of the denervated muscles. The cross sections of the muscles were determined by 2D Color CT, while muscle volumes were reconstructed by 3D Color CT. Shape, volume, and density changes were measured over the entirety of each rectus femoris muscle. Changes in tissue composition within the muscle were visualized by associating different colors to specified Hounsfield unit (HU values for fat, (yellow: [-200; -10], loose connective tissue or atrophic muscle, (cyan: [-9; 40], and normal muscle, fascia and tendons included, (red: [41; 200]. The results from this analysis are presented as the average HU values within the rectus femoris muscle reconstruction, as well as the percentage of these tissues with respect to the total muscle volume. Results from this study demonstrate that h-b FES induces a compliance-dependent recovery of muscle volume and size of muscle fibers, as

  11. Technical and functional analysis of Albolafia waterwheel (Cordoba, Spain): 3D modeling, computational-fluid dynamics simulation and finite-element analysis

    International Nuclear Information System (INIS)

    Highlights: • Technical and functional analysis of the Albolafia waterwheel (Córdoba, Spain). • Spatial distribution of speeds using computational-fluid dynamics simulation (CFD). • Finite-element analysis (FEA) of the waterwheel. • Dynamic simulation of the waterwheel using Computer-Aided Engineering (CAE) techniques. • Validation of the operation of the waterwheel. - Abstract: A detailed study has been made of a vertical waterwheel, the wheel of Albolafia situated on the Guadalquivir river near the city of Cordoba (Spain). We propose a methodology for ad hoc research based on three aspects: 3D geometric modeling, analysis with computational fluid-dynamics techniques and dynamic simulation of the whole and its finite-element analysis. The results show the correct operation of the waterwheel with an initial moment of inertia of 90,800 N m and a range of water-flow speeds of between 0.91 and 1.01 m/s. These values are related to the average flow of the river, which allowed the wheel to operate at least 124 days per year. The spatial distribution of stresses has shown that the full buckets created an imbalance compared with the empty ones, and that the star-shaped polygon reinforcement effectively absorbed these tensions. In addition, the oak wood used in the construction of the waterwheel proved highly resistant, as the maximum working stress has never been surpassed, reflecting the effectiveness of the materials used at the time

  12. 3D Printing and Its Urologic Applications.

    Science.gov (United States)

    Soliman, Youssef; Feibus, Allison H; Baum, Neil

    2015-01-01

    3D printing is the development of 3D objects via an additive process in which successive layers of material are applied under computer control. This article discusses 3D printing, with an emphasis on its historical context and its potential use in the field of urology.

  13. NIF Ignition Target 3D Point Design

    Energy Technology Data Exchange (ETDEWEB)

    Jones, O; Marinak, M; Milovich, J; Callahan, D

    2008-11-05

    We have developed an input file for running 3D NIF hohlraums that is optimized such that it can be run in 1-2 days on parallel computers. We have incorporated increasing levels of automation into the 3D input file: (1) Configuration controlled input files; (2) Common file for 2D and 3D, different types of capsules (symcap, etc.); and (3) Can obtain target dimensions, laser pulse, and diagnostics settings automatically from NIF Campaign Management Tool. Using 3D Hydra calculations to investigate different problems: (1) Intrinsic 3D asymmetry; (2) Tolerance to nonideal 3D effects (e.g. laser power balance, pointing errors); and (3) Synthetic diagnostics.

  14. IZDELAVA TISKALNIKA 3D

    OpenAIRE

    Brdnik, Lovro

    2015-01-01

    Diplomsko delo analizira trenutno stanje 3D tiskalnikov na trgu. Prikazan je razvoj in principi delovanja 3D tiskalnikov. Predstavljeni so tipi 3D tiskalnikov, njihove prednosti in slabosti. Podrobneje je predstavljena zgradba in delovanje koračnih motorjev. Opravljene so meritve koračnih motorjev. Opisana je programska oprema za rokovanje s 3D tiskalniki in komponente, ki jih potrebujemo za izdelavo. Diploma se oklepa vprašanja, ali je izdelava 3D tiskalnika bolj ekonomična kot pa naložba v ...

  15. Plane 3D effect display based on computer vision%基于计算机视觉的平面3D效果显示

    Institute of Scientific and Technical Information of China (English)

    阚洪

    2016-01-01

    The 3D display technology is the research hotpot of current computer graphic image technology,and high atten⁃tion is paid to realization of its true vision experience on the plane. In order to promote the 3D experience of users,a 3D display based on computer vision is presented,which can eliminate the reflected light interference from human eyes by means of Win⁃dows operation system,infrared image acquisition device operated by OpenCV,and visible light filter. An efficient human pupil location algorithm is proposed,by which the approximate location of human eyes is determined through gray integral projection, and then the binary image is got with the optimized threshold segmentation method. On this basis,the morphological operation for the binary image is conducted to eliminate the noise and make the image processing easier. The algorithm combined corner detection based on OpenCV with ellipse fitting is used to locate the pupil,which is simple and efficient. The camera location is realized on the basis of cvCalibrateCamera function of OpenCV. Finally,the envisaged image of 3D display was accomplished with Bresenham line drawing method. To make the system have better real⁃time performance,the scanning area segmentation method and target area prediction method are used to reduce the system computing amount and realize fast tracking of human eyes.%3D显示技术作为当前计算机图形图像技术的研究热点,以其在平面上实现真实的视觉体验而获得高度重视。为了提升用户的3D体验,提出了一种基于计算机视觉的3D显示器。借助于Windows操作系统,通过OpenCV操作红外图像采集设备,搭配可见光滤光镜,消除了人眼反射光的干扰。提出了一种比较高效的人类瞳孔定位算法,首先利用灰度积分投影将人眼的大概位置确定,之后使用优化的阈值分割方法得到二值图像,在此基础上对其进行形态学运算去除噪声,使图像更易处理。

  16. 使用计算机视觉的3D模型动作记录器%3D Model Action Recording System Using Computer Visions

    Institute of Scientific and Technical Information of China (English)

    丁志远

    2013-01-01

    该文旨在完成一款基于计算机视觉的3D模型动作记录器,即计算机通过摄像头获取人体运动视频并检测跟踪,之后通过处理数据控制3D模型,从而将人体动作进行记录保存。文章主要围绕运动目标检测、运动目标跟踪和3D建模三个方面展开研究。运动目标检测方面使用OpenCV(Open Source Computer Vision Library)提供的背景差分算法对目标进行分析并提取差分元素;运动目标跟踪方面则研究了常用的Camshift跟踪算法,实现对运动目标的连续跟踪以及识别从而保证动作记录器的连贯性;3D建模部分则使用3Dmax进行建立模型以及骨骼动画的制作处理,并使用Ogremax导出模型;而模型的骨骼动画则由OGRE导入测试环境并根据之前的处理结果进行相应的控制,从而实现人体运动的动作记录。%This paper present a 3D model action recording system using computer visions. A computer captures human motion videos with a network camera and conduct further detection and tracking of the video resources, then a 3D model was created based on the recorded data results. The action recording system includes motion target detection, motion target tracking and 3D modeling. OpenCV is used in the motion target detection where background image difference algorithm is used to analyze the moving target and extract different elements. For the motion target tracking, the Camshift tracking algorithm is used to realize continuous tracking and recognition of moving objects and ensure good performance of the action recorder. In our implementa-tion, 3Dmax is used to build the 3D model and skeletal animations, where Ogremax is used to export models, and then to im-port the skeletal animations into the test enviroment. The evaluations show that our motion recognition and recording system has good performance in one aspect, and can obtain accurate result on the other aspect.

  17. Face Detection with a 3D Model

    OpenAIRE

    Barbu, Adrian; Lay, Nathan; Gramajo, Gary

    2014-01-01

    This paper presents a part-based face detection approach where the spatial relationship between the face parts is represented by a hidden 3D model with six parameters. The computational complexity of the search in the six dimensional pose space is addressed by proposing meaningful 3D pose candidates by image-based regression from detected face keypoint locations. The 3D pose candidates are evaluated using a parameter sensitive classifier based on difference features relative to the 3D pose. A...

  18. 3D and Education

    Science.gov (United States)

    Meulien Ohlmann, Odile

    2013-02-01

    Today the industry offers a chain of 3D products. Learning to "read" and to "create in 3D" becomes an issue of education of primary importance. 25 years professional experience in France, the United States and Germany, Odile Meulien set up a personal method of initiation to 3D creation that entails the spatial/temporal experience of the holographic visual. She will present some different tools and techniques used for this learning, their advantages and disadvantages, programs and issues of educational policies, constraints and expectations related to the development of new techniques for 3D imaging. Although the creation of display holograms is very much reduced compared to the creation of the 90ies, the holographic concept is spreading in all scientific, social, and artistic activities of our present time. She will also raise many questions: What means 3D? Is it communication? Is it perception? How the seeing and none seeing is interferes? What else has to be taken in consideration to communicate in 3D? How to handle the non visible relations of moving objects with subjects? Does this transform our model of exchange with others? What kind of interaction this has with our everyday life? Then come more practical questions: How to learn creating 3D visualization, to learn 3D grammar, 3D language, 3D thinking? What for? At what level? In which matter? for whom?

  19. Development of a lab-scale, high-resolution, tube-generated X-ray computed-tomography system for three-dimensional (3D) materials characterization

    Energy Technology Data Exchange (ETDEWEB)

    Mertens, J.C.E., E-mail: james.mertens@asu.edu; Williams, J.J., E-mail: jason.williams@asu.edu; Chawla, Nikhilesh, E-mail: nchawla@asu.edu

    2014-06-01

    The design and construction of a modular high resolution X-ray computed tomography (XCT) system is highlighted in this paper. The design approach is detailed for meeting a specified set of instrument performance goals tailored towards experimental versatility and high resolution imaging. The XCT tool is unique in the detector and X-ray source design configuration, enabling control in the balance between detection efficiency and spatial resolution. The system package is also unique: The sample manipulation approach implemented enables a wide gamut of in situ experimentation to analyze structure evolution under applied stimulus, by optimizing scan conditions through a high degree of controllability. The component selection and design process is detailed: Incorporated components are specified, custom designs are shared, and the approach for their integration into a fully functional XCT scanner is provided. Custom designs discussed include the dual-target X-ray source cradle which maintains position and trajectory of the beam between the two X-ray target configurations with respect to a scintillator mounting and positioning assembly and the imaging sensor, as well as a novel large-format X-ray detector with enhanced adaptability. The instrument is discussed from an operational point of view, including the details of data acquisition and processing implemented for 3D imaging via micro-CT. The performance of the instrument is demonstrated on a silica-glass particle/hydroxyl-terminated-polybutadiene (HTPB) matrix binder PBX simulant. Post-scan data processing, specifically segmentation of the sample's relevant microstructure from the 3D reconstruction, is provided to demonstrate the utility of the instrument. - Highlights: • Custom built X-ray tomography system for microstructural characterization • Detector design for maximizing polychromatic X-ray detection efficiency • X-ray design offered for maximizing X-ray flux with respect to imaging resolution

  20. Plasma-material interactions: A Langmuir probe analysis of a cylindrical SiO(2) deposition system and a computational study using VFTRIM3D

    Science.gov (United States)

    Turkot, Robert Bruce, Jr.

    This dissertation is broken into two sections describing, first, a computer code simulating ion-surface interactions, VFTRIM3D, and, second, an experimental Langmuir probe analysis of a cylindrical SiOsb2 deposition system. VFTRIM3D is a 3-dimensional, Monte-Carlo, binary collision code employing fractal algorithms used to simulate atomic-scale surface roughness. This work applies this code to studies of incident ion energies in the 10's to 100's of eV on various targets and comparisons to experimental data prove its dependability for such simulations. The experimental portion of this thesis includes the development and investigation of a cylindrical SiOsb2 deposition system used to deposit gas permeation barrier thin films onto PET bottles. The plasma analysis is done utilizing time- and spatially resolved Langmuir probe techniques. In order to study the characteristics of the dielectric deposition plasma, a "hot" Langmuir probe was developed to acquire typical Langmuir probe data during SiOsb2 deposition. The SiOsb2 films deposited in this system are analyzed for their gas permeation qualities and are correlated to the plasma properties gathered using Langmuir probes as well as the gas, pressure, and time recipes used to produce them. It is found in this work that the application of SiOsb2 films onto flexible PET bottles using the fashion explained herein results in a decrease in the gas permeation characteristics of the SiOsb2-PET membrane as desired, but is found to be independent of the thickness of the SiOsb2 present. This limit is found to be caused by cracks and pinhole defects across the SiOsb2 film that permit uninhibited gas flow directly to the PET bottle.

  1. Use of short roll C-arm computed tomography and fully automated 3D analysis tools to guide transcatheter aortic valve replacement.

    Science.gov (United States)

    Kim, Michael S; Bracken, John; Eshuis, Peter; Chen, S Y James; Fullerton, David; Cleveland, Joseph; Messenger, John C; Carroll, John D

    2016-07-01

    Determination of the coplanar view is a critical component of transcatheter aortic valve replacement (TAVR). The safety and accuracy of a novel reduced angular range C-arm computed tomography (CACT) approach coupled with a fully automated 3D analysis tool package to predict the coplanar view in TAVR was evaluated. Fifty-seven patients with severe symptomatic aortic stenosis deemed prohibitive-risk for surgery and who underwent TAVR were enrolled. Patients were randomized 2:1 to CACT vs. angiography (control) in estimating the coplanar view. These approaches to determine the coplanar view were compared quantitatively. Radiation doses needed to determine the coplanar view were recorded for both the CACT and control patients. Use of CACT offered good agreement with the actual angiographic view utilized during TAVR in 34 out of 41 cases in which a CACT scan was performed (83 %). For these 34 cases, the mean angular magnitude difference, taking into account both oblique and cranial/caudal angulation, was 1.3° ± 0.4°, while the maximum difference was 7.3°. There were no significant differences in the mean total radiation dose delivered to patients between the CACT and control groups as measured by either dose area product (207.8 ± 15.2 Gy cm(2) vs. 186.1 ± 25.3 Gy cm(2), P = 0.47) or air kerma (1287.6 ± 117.7 mGy vs. 1098.9 ± 143.8 mGy, P = 0.32). Use of reduced-angular range CACT coupled with fully automated 3D analysis tools is a safe, practical, and feasible method by which to determine the optimal angiographic deployment view for guiding TAVR procedures. PMID:27091735

  2. Axial stent strut angle influences wall shear stress after stent implantation: analysis using 3D computational fluid dynamics models of stent foreshortening

    Directory of Open Access Journals (Sweden)

    Warltier David C

    2005-10-01

    Full Text Available Abstract Introduction The success of vascular stents in the restoration of blood flow is limited by restenosis. Recent data generated from computational fluid dynamics (CFD models suggest that the vascular geometry created by an implanted stent causes local alterations in wall shear stress (WSS that are associated with neointimal hyperplasia (NH. Foreshortening is a potential limitation of stent design that may affect stent performance and the rate of restenosis. The angle created between axially aligned stent struts and the principal direction of blood flow varies with the degree to which the stent foreshortens after implantation. Methods In the current investigation, we tested the hypothesis that stent foreshortening adversely influences the distribution of WSS and WSS gradients using time-dependent 3D CFD simulations of normal arteries based on canine coronary artery measurements of diameter and blood flow. WSS and WSS gradients were calculated using conventional techniques in ideal (16 mm and progressively foreshortened (14 and 12 mm stented computational vessels. Results Stent foreshortening increased the intrastrut area of the luminal surface exposed to low WSS and elevated spatial WSS gradients. Progressive degrees of stent foreshortening were also associated with strut misalignment relative to the direction of blood flow as indicated by analysis of near-wall velocity vectors. Conclusion The current results suggest that foreshortening may predispose the stented vessel to a higher risk of neointimal hyperplasia.

  3. Micro/nano-computed tomography technology for quantitative dynamic, multi-scale imaging of morphogenesis.

    Science.gov (United States)

    Gregg, Chelsea L; Recknagel, Andrew K; Butcher, Jonathan T

    2015-01-01

    Tissue morphogenesis and embryonic development are dynamic events challenging to quantify, especially considering the intricate events that happen simultaneously in different locations and time. Micro- and more recently nano-computed tomography (micro/nanoCT) has been used for the past 15 years to characterize large 3D fields of tortuous geometries at high spatial resolution. We and others have advanced micro/nanoCT imaging strategies for quantifying tissue- and organ-level fate changes throughout morphogenesis. Exogenous soft tissue contrast media enables visualization of vascular lumens and tissues via extravasation. Furthermore, the emergence of antigen-specific tissue contrast enables direct quantitative visualization of protein and mRNA expression. Micro-CT X-ray doses appear to be non-embryotoxic, enabling longitudinal imaging studies in live embryos. In this chapter we present established soft tissue contrast protocols for obtaining high-quality micro/nanoCT images and the image processing techniques useful for quantifying anatomical and physiological information from the data sets.

  4. Documentation of a computer program to simulate lake-aquifer interaction using the MODFLOW ground water flow model and the MOC3D solute-transport model

    Science.gov (United States)

    Merritt, Michael L.; Konikow, Leonard F.

    2000-01-01

    Heads and flow patterns in surficial aquifers can be strongly influenced by the presence of stationary surface-water bodies (lakes) that are in direct contact, vertically and laterally, with the aquifer. Conversely, lake stages can be significantly affected by the volume of water that seeps through the lakebed that separates the lake from the aquifer. For these reasons, a set of computer subroutines called the Lake Package (LAK3) was developed to represent lake/aquifer interaction in numerical simulations using the U.S. Geological Survey three-dimensional, finite-difference, modular ground-water flow model MODFLOW and the U.S. Geological Survey three-dimensional method-of-characteristics solute-transport model MOC3D. In the Lake Package described in this report, a lake is represented as a volume of space within the model grid which consists of inactive cells extending downward from the upper surface of the grid. Active model grid cells bordering this space, representing the adjacent aquifer, exchange water with the lake at a rate determined by the relative heads and by conductances that are based on grid cell dimensions, hydraulic conductivities of the aquifer material, and user-specified leakance distributions that represent the resistance to flow through the material of the lakebed. Parts of the lake may become ?dry? as upper layers of the model are dewatered, with a concomitant reduction in lake surface area, and may subsequently rewet when aquifer heads rise. An empirical approximation has been encoded to simulate the rewetting of a lake that becomes completely dry. The variations of lake stages are determined by independent water budgets computed for each lake in the model grid. This lake budget process makes the package a simulator of the response of lake stage to hydraulic stresses applied to the aquifer. Implementation of a lake water budget requires input of parameters including those representing the rate of lake atmospheric recharge and evaporation

  5. MPML3D: Scripting Agents for the 3D Internet.

    Science.gov (United States)

    Prendinger, Helmut; Ullrich, Sebastian; Nakasone, Arturo; Ishizuka, Mitsuru

    2011-05-01

    The aim of this paper is two-fold. First, it describes a scripting language for specifying communicative behavior and interaction of computer-controlled agents ("bots") in the popular three-dimensional (3D) multiuser online world of "Second Life" and the emerging "OpenSimulator" project. While tools for designing avatars and in-world objects in Second Life exist, technology for nonprogrammer content creators of scenarios involving scripted agents is currently missing. Therefore, we have implemented new client software that controls bots based on the Multimodal Presentation Markup Language 3D (MPML3D), a highly expressive XML-based scripting language for controlling the verbal and nonverbal behavior of interacting animated agents. Second, the paper compares Second Life and OpenSimulator platforms and discusses the merits and limitations of each from the perspective of agent control. Here, we also conducted a small study that compares the network performance of both platforms.

  6. 3D laptop for defense applications

    Science.gov (United States)

    Edmondson, Richard; Chenault, David

    2012-06-01

    Polaris Sensor Technologies has developed numerous 3D display systems using a US Army patented approach. These displays have been developed as prototypes for handheld controllers for robotic systems and closed hatch driving, and as part of a TALON robot upgrade for 3D vision, providing depth perception for the operator for improved manipulation and hazard avoidance. In this paper we discuss the prototype rugged 3D laptop computer and its applications to defense missions. The prototype 3D laptop combines full temporal and spatial resolution display with the rugged Amrel laptop computer. The display is viewed through protective passive polarized eyewear, and allows combined 2D and 3D content. Uses include robot tele-operation with live 3D video or synthetically rendered scenery, mission planning and rehearsal, enhanced 3D data interpretation, and simulation.

  7. 3D virtuel udstilling

    DEFF Research Database (Denmark)

    Tournay, Bruno; Rüdiger, Bjarne

    2006-01-01

    3d digital model af Arkitektskolens gård med virtuel udstilling af afgangsprojekter fra afgangen sommer 2006. 10 s.......3d digital model af Arkitektskolens gård med virtuel udstilling af afgangsprojekter fra afgangen sommer 2006. 10 s....

  8. Research of Humanoid Robot Voluntary Movement in 3D Computer Animation%电脑动画中3D虚拟人自主运动的研究

    Institute of Scientific and Technical Information of China (English)

    钱驰波; 薛晓明

    2011-01-01

    电脑动画中复杂环境下3D虚拟人自主运动的研究,是计算机图像处理技术发展过程中急待突破的一个环节.主要原因是传统处理的方式过于复杂耗时.针对上述问题,应用计划分离器建立虚拟人的运动模型,使虚拟人在高低不平的环境中实现正步走、侧走、跑步及跳跃等程序性动画.实验结果表明:提出的方法简单、快捷.%It is urgent breakthrough technology for the development of computer image processing to research 3D humanoid robot voluntary movement in the complex environment due to the traditional way of dealing with timeconsuming and too complex. In response to these problems, a motion planning system capable of generating both global and local motions for a humanoid robot in a layered or two and half dimensional environment are proposed, so that the humanoid robot in the rugged environment to achieve frontal and side walking, jogging and jumping procedural animation. The results show that the proposed method is simple and fast.

  9. Image fusion of Ultrasound Computer Tomography volumes with X-ray mammograms using a biomechanical model based 2D/3D registration.

    Science.gov (United States)

    Hopp, T; Duric, N; Ruiter, N V

    2015-03-01

    Ultrasound Computer Tomography (USCT) is a promising breast imaging modality under development. Comparison to a standard method like mammography is essential for further development. Due to significant differences in image dimensionality and compression state of the breast, correlating USCT images and X-ray mammograms is challenging. In this paper we present a 2D/3D registration method to improve the spatial correspondence and allow direct comparison of the images. It is based on biomechanical modeling of the breast and simulation of the mammographic compression. We investigate the effect of including patient-specific material parameters estimated automatically from USCT images. The method was systematically evaluated using numerical phantoms and in-vivo data. The average registration accuracy using the automated registration was 11.9mm. Based on the registered images a method for analysis of the diagnostic value of the USCT images was developed and initially applied to analyze sound speed and attenuation images based on X-ray mammograms as ground truth. Combining sound speed and attenuation allows differentiating lesions from surrounding tissue. Overlaying this information on mammograms, combines quantitative and morphological information for multimodal diagnosis. PMID:25456144

  10. General design method for 3-dimensional, potential flow fields. Part 2: Computer program DIN3D1 for simple, unbranched ducts

    Science.gov (United States)

    Stanitz, J. D.

    1985-01-01

    The general design method for three-dimensional, potential, incompressible or subsonic-compressible flow developed in part 1 of this report is applied to the design of simple, unbranched ducts. A computer program, DIN3D1, is developed and five numerical examples are presented: a nozzle, two elbows, an S-duct, and the preliminary design of a side inlet for turbomachines. The two major inputs to the program are the upstream boundary shape and the lateral velocity distribution on the duct wall. As a result of these inputs, boundary conditions are overprescribed and the problem is ill posed. However, it appears that there are degrees of compatibility between these two major inputs and that, for reasonably compatible inputs, satisfactory solutions can be obtained. By not prescribing the shape of the upstream boundary, the problem presumably becomes well posed, but it is not clear how to formulate a practical design method under this circumstance. Nor does it appear desirable, because the designer usually needs to retain control over the upstream (or downstream) boundary shape. The problem is further complicated by the fact that, unlike the two-dimensional case, and irrespective of the upstream boundary shape, some prescribed lateral velocity distributions do not have proper solutions.

  11. Computational design and multiscale modeling of a nanoactuator using DNA actuation

    International Nuclear Information System (INIS)

    Developments in the field of nano-biodevices coupling nanostructures and biological components are of great interest in medical nanorobotics. As the fundamentals of bio/non-bio interaction processes are still poorly understood in the design of these devices, design tools and multiscale dynamics modeling approaches are necessary at the fabrication pre-project stage. This paper proposes a new concept of optimized carbon nanotube based servomotor design for drug delivery and biomolecular transport applications. The design of an encapsulated DNA-multi-walled carbon nanotube actuator is prototyped using multiscale modeling. The system is parametrized by using a quantum level approach and characterized by using a molecular dynamics simulation. Based on the analysis of the simulation results, a servo nanoactuator using ionic current feedback is simulated and analyzed for application as a drug delivery carrier.

  12. View-based 3-D object retrieval

    CERN Document Server

    Gao, Yue

    2014-01-01

    Content-based 3-D object retrieval has attracted extensive attention recently and has applications in a variety of fields, such as, computer-aided design, tele-medicine,mobile multimedia, virtual reality, and entertainment. The development of efficient and effective content-based 3-D object retrieval techniques has enabled the use of fast 3-D reconstruction and model design. Recent technical progress, such as the development of camera technologies, has made it possible to capture the views of 3-D objects. As a result, view-based 3-D object retrieval has become an essential but challenging res

  13. Multiscale Nonconforming Finite Element Computation to Small Periodic Composite Materials of Elastic Structures on Anisotropic Meshes

    Directory of Open Access Journals (Sweden)

    Ying Hao

    2016-01-01

    Full Text Available The small periodic elastic structures of composite materials with the multiscale asymptotic expansion and homogenized method are discussed. A nonconforming Crouzeix-Raviart finite element is applied to calculate every term of the asymptotic expansion on anisotropic meshes. The approximation scheme to the higher derivatives of the homogenized solution is also derived. Finally, the optimal error estimate in ·h for displacement vector is obtained.

  14. A Multiscale Computational Model of the Heart: Exploring Space Medicine and Terrestrial Applications

    Science.gov (United States)

    Gladding, Patrick; Orr, Martin; Kazuaki, Negishi; Borowski, Alan; Hussan, Jagir R.; Hunter, Peter; Kassemi, Mohammed; Martin, David; Levine, Benjamin; Schlegel, Todd T.; Thomas, James D.

    2016-01-01

    The impact of long-term spaceflight on cardiac electromechanical function is unknown. Integrating heterogeneous biophysical data from sources such as echocardiography (Echo), electrocardiography (ECG), and genomics into a mathematical model could be used to predict cardiac dysfunction in space. We have developed a multiscale heart model, onto which astronaut-specific ultrasound data can be imposed, with the aim of integrating advanced ECG (A-ECG) and genomic data.

  15. Diffusible iodine-based contrast-enhanced computed tomography (diceCT): an emerging tool for rapid, high-resolution, 3-D imaging of metazoan soft tissues.

    Science.gov (United States)

    Gignac, Paul M; Kley, Nathan J; Clarke, Julia A; Colbert, Matthew W; Morhardt, Ashley C; Cerio, Donald; Cost, Ian N; Cox, Philip G; Daza, Juan D; Early, Catherine M; Echols, M Scott; Henkelman, R Mark; Herdina, A Nele; Holliday, Casey M; Li, Zhiheng; Mahlow, Kristin; Merchant, Samer; Müller, Johannes; Orsbon, Courtney P; Paluh, Daniel J; Thies, Monte L; Tsai, Henry P; Witmer, Lawrence M

    2016-06-01

    Morphologists have historically had to rely on destructive procedures to visualize the three-dimensional (3-D) anatomy of animals. More recently, however, non-destructive techniques have come to the forefront. These include X-ray computed tomography (CT), which has been used most commonly to examine the mineralized, hard-tissue anatomy of living and fossil metazoans. One relatively new and potentially transformative aspect of current CT-based research is the use of chemical agents to render visible, and differentiate between, soft-tissue structures in X-ray images. Specifically, iodine has emerged as one of the most widely used of these contrast agents among animal morphologists due to its ease of handling, cost effectiveness, and differential affinities for major types of soft tissues. The rapid adoption of iodine-based contrast agents has resulted in a proliferation of distinct specimen preparations and scanning parameter choices, as well as an increasing variety of imaging hardware and software preferences. Here we provide a critical review of the recent contributions to iodine-based, contrast-enhanced CT research to enable researchers just beginning to employ contrast enhancement to make sense of this complex new landscape of methodologies. We provide a detailed summary of recent case studies, assess factors that govern success at each step of the specimen storage, preparation, and imaging processes, and make recommendations for standardizing both techniques and reporting practices. Finally, we discuss potential cutting-edge applications of diffusible iodine-based contrast-enhanced computed tomography (diceCT) and the issues that must still be overcome to facilitate the broader adoption of diceCT going forward. PMID:26970556

  16. Remote 3D Medical Consultation

    Science.gov (United States)

    Welch, Greg; Sonnenwald, Diane H.; Fuchs, Henry; Cairns, Bruce; Mayer-Patel, Ketan; Yang, Ruigang; State, Andrei; Towles, Herman; Ilie, Adrian; Krishnan, Srinivas; Söderholm, Hanna M.

    Two-dimensional (2D) video-based telemedical consultation has been explored widely in the past 15-20 years. Two issues that seem to arise in most relevant case studies are the difficulty associated with obtaining the desired 2D camera views, and poor depth perception. To address these problems we are exploring the use of a small array of cameras to synthesize a spatially continuous range of dynamic three-dimensional (3D) views of a remote environment and events. The 3D views can be sent across wired or wireless networks to remote viewers with fixed displays or mobile devices such as a personal digital assistant (PDA). The viewpoints could be specified manually or automatically via user head or PDA tracking, giving the remote viewer virtual head- or hand-slaved (PDA-based) remote cameras for mono or stereo viewing. We call this idea remote 3D medical consultation (3DMC). In this article we motivate and explain the vision for 3D medical consultation; we describe the relevant computer vision/graphics, display, and networking research; we present a proof-of-concept prototype system; and we present some early experimental results supporting the general hypothesis that 3D remote medical consultation could offer benefits over conventional 2D televideo.

  17. Comparison of 16 slice multi-detector computed tomography and breath hold 3D magnetic resonance angiography in the detection of coronary stenosis

    Institute of Scientific and Technical Information of China (English)

    Xin LIU; Zulong CAI; Youquan CAI; Shaohong ZHAO; Ningyu AN; Yuangui GAO

    2006-01-01

    Objective To compare 16-slice multi-detector spiral computed tomography (MDCT) and breathhold 3D magnetic resonance (MR) coronary angiography in the visualization of coronary arteries and the accuracy of detecting significant (> 50%) coronary stenoses in patients with suspected coronary artery disease. Methods Forty patients were examined by 16-slice CT (GE, Lightspeedl6)and MR (GE,Twinspeed) within 3 days; 31 of them underwent conventional coronary angiography (CAG) within 2 weeks after CT and MR scan. CT was performed with 16× 1.25 mm detector collimation, 0.5 s rotation time and images were reconstructed at 60%-75% of the cardiac cycle. MR was performed with breath hold 3D FIESTA (TR4.0 ms, TE1.7 ms, flip angle 65, slice thickness 3 mm, FOV 280 mm, matrix 256× 192). Mean heart rate was 63 ± 5.8 bpm and β-blocker was used in 24 patients. MR and CT image quality was evaluated in 9 coronary segments (RCA1, RCA2, RCA3, LM, LAD1, LAD2, LAD3, LCX1, LCX2) using a four-point grading scale.Sensitivity, specificity, positive predictive value, negative predictive value and accuracy were calculated for detection of significant stenosis using CAG as the gold standard. Results 16-slice CT showed higher image quality in most coronary segments except RCA2.Forty-three segments were diagnosed as significant stenosis by CAG, 36 and 27 of these were correctly detected by CT and MR respectively. Sensitivity, specificity, positive predictive value, and negative predictive value of 16-slice CT and MR for detecting significant stenosis were 83 %, 84 %, 49 %, 97 % and 63 %, 90 %, 55 %, 93 %, respectively. Conclusion Sixteen-slice CT showed higher image quality in most coronary segments excepted for middle RCA. 16-slice CT had higher sensitivity than MR for detection of coronary significant stenosis, whereas MR had higher specificity than CT. Both CT and MR showed high negative predictive value,which is useful for excluding coronary stenosis in symptomatic patients.

  18. Geodesy-based estimates of loading rates on faults beneath the Los Angeles basin with a new, computationally efficient method to model dislocations in 3D heterogeneous media

    Science.gov (United States)

    Rollins, C.; Argus, D. F.; Avouac, J. P.; Landry, W.; Barbot, S.

    2015-12-01

    North-south compression across the Los Angeles basin is accommodated by slip on thrust faults beneath the basin that may present significant seismic hazard to Los Angeles. Previous geodesy-based efforts to constrain the distributions and rates of elastic strain accumulation on these faults [Argus et al 2005, 2012] have found that the elastic model used has a first-order impact on the inferred distribution of locking and creep, underlining the need to accurately incorporate the laterally heterogeneous elastic structure and complex fault geometries of the Los Angeles basin into this analysis. We are using Gamra [Landry and Barbot, in prep.], a newly developed adaptive-meshing finite-difference solver, to compute elastostatic Green's functions that incorporate the full 3D regional elastic structure provided by the SCEC Community Velocity Model. Among preliminary results from benchmarks, forward models and inversions, we find that: 1) for a modeled creep source on the edge dislocation geometry from Argus et al [2005], the use of the SCEC CVM material model produces surface velocities in the hanging wall that are up to ~50% faster than those predicted in an elastic halfspace model; 2) in sensitivity-modulated inversions of the Argus et al [2005] GPS velocity field for slip on the same dislocation source, the use of the CVM deepens the inferred locking depth by ≥3 km compared to an elastic halfspace model; 3) when using finite-difference or finite-element models with Dirichlet boundary conditions (except for the free surface) for problems of this scale, it is necessary to set the boundaries at least ~100 km away from any slip source or data point to guarantee convergence within 5% of analytical solutions (a result which may be applicable to other static dislocation modeling problems and which may scale with the size of the area of interest). Here we will present finalized results from inversions of an updated GPS velocity field [Argus et al, AGU 2015] for the inferred

  19. Computing 3-D wavefields in mantle circulations models to test hypotheses on the origin of lower mantle heterogeneity under Africa directly against seismic observations

    Science.gov (United States)

    Schuberth, Bernhard; Zaroli, Christophe; Nolet, Guust

    2015-04-01

    Of particular interest for the tectonic evolution of the Atlantic region is the influence of lower mantle structure under Africa on flow in the upper mantle beneath the ocean basin. Along with its Pacific counterpart, the large African anomaly in the lowermost mantle with strongly reduced seismic velocities has received considerable attention in seismological and geodynamic studies. Several seismological observations are typically taken as an indication that these two anomalies are being caused by large-scale compositional variations and that they are piles of material with higher density than normal mantle rock. This would imply negative buoyancy in the lowermost mantle under Africa, which has important implications for the flow at shallower depth and inferences on the processes that led to the formation of the Atlantic Ocean basin. However, a large number of recent studies argue for a strong thermal gradient across the core-mantle boundary that might provide an alternative explanation for the lower mantle anomaly through the resulting large lateral temperature variations. Recently, we developed a new joint forward modeling approach to test such geodynamic hypotheses directly against the seismic observations: Seismic heterogeneity is predicted by converting the temperature field of a high-resolution 3-D mantle circulation model into seismic velocities using thermodynamic models of mantle mineralogy. 3-D global wave propagation in the synthetic elastic structures is then simulated using a spectral element method. Being based on forward modelling only, this approach allows us to generate synthetic wavefields and seismograms independently of seismic observations. The statistics of observed long-period body wave traveltime variations show a markedly different behaviour for P- and S-waves: the standard deviation of P-wave delay times stays almost constant with ray turning depth, while that of the S-wave delay times increases strongly throughout the mantle. In an

  20. Assessment of Image Processing and Resolution on Permeability and Drainage Simulations Through 3D Pore-networks Obtained Using X-ray Computed Tomography

    Science.gov (United States)

    Mills, G.; Willson, C. S.; Thompson, K. E.; Rivers, M. L.

    2013-12-01

    Typically, continuum-scale flow parameters are obtained through laboratory experiments. Over the past several years, image-based modeling, which is a direct simulation of flow through the structural arrangements of the voids and solids obtained using X-ray computed tomography (XCT) in a sample porous medium, has become a reliable technique for predicting certain flow parameters. Even though XCT is capable of resolving micron-level details, the voxel resolution of the reconstructed image is still dependent upon a number of factors, including the sample size, X-ray energy and XCT beamline setup. Thus, each imaging experiment requires a tradeoff between the sample size that can be imaged, the voxel resolution, and the length scale of the pore space that can be extracted. In addition, the geometric and topological properties of the void space and 3D pore network structure are dictated by the image processing and the choice of pore network generation method. In this research, image-based pore network models are used to quantitatively assess the impact of image resolution, image processing and the choice of pore network generation methods on simulated parameters. A 5 mm diameter and ~15 mm in length Berea sandstone core was scanned two times. First, a ~12 mm long section of the entire cross-section was scanned at 4.1 micron voxel resolution; next, a ~1.4 mm diameter and ~4.12 mm length section within the 1st domain was scanned at 1 micron voxel resolution. The resulting 3D datasets were filtered and segmented into solid and void space. The low resolution image was filtered and segmented using two different approaches in order to evaluate the potential of each approach in identifying the different solid phases in the original 16 bit dataset. A set of networks were created by varying the pore density on both the high and low resolution datasets in order to assess the impact of these factors on flow simulations. Single-phase permeability and a two-phase drainage pore

  1. Blender 3D cookbook

    CERN Document Server

    Valenza, Enrico

    2015-01-01

    This book is aimed at the professionals that already have good 3D CGI experience with commercial packages and have now decided to try the open source Blender and want to experiment with something more complex than the average tutorials on the web. However, it's also aimed at the intermediate Blender users who simply want to go some steps further.It's taken for granted that you already know how to move inside the Blender interface, that you already have 3D modeling knowledge, and also that of basic 3D modeling and rendering concepts, for example, edge-loops, n-gons, or samples. In any case, it'

  2. Development of a computational system for radiotherapic planning with the IMRT technique applied to the MCNP computer code with 3D graphic interface for voxel models

    International Nuclear Information System (INIS)

    The Intensity Modulated Radiation Therapy - IMRT is an advanced treatment technique used worldwide in oncology medicine branch. On this master proposal was developed a software package for simulating the IMRT protocol, namely SOFT-RT which attachment the research group 'Nucleo de Radiacoes Ionizantes' - NRI at UFMG. The computational system SOFT-RT allows producing the absorbed dose simulation of the radiotherapic treatment through a three-dimensional voxel model of the patient. The SISCODES code, from NRI, research group, helps in producing the voxel model of the interest region from a set of CT or MRI digitalized images. The SOFT-RT allows also the rotation and translation of the model about the coordinate system axis for better visualization of the model and the beam. The SOFT-RT collects and exports the necessary parameters to MCNP code which will carry out the nuclear radiation transport towards the tumor and adjacent healthy tissues for each orientation and position of the beam planning. Through three-dimensional visualization of voxel model of a patient, it is possible to focus on a tumoral region preserving the whole tissues around them. It takes in account where exactly the radiation beam passes through, which tissues are affected and how much dose is applied in both tissues. The Out-module from SOFT-RT imports the results and express the dose response superimposing dose and voxel model in gray scale in a three-dimensional graphic representation. The present master thesis presents the new computational system of radiotherapic treatment - SOFT-RT code which has been developed using the robust and multi-platform C++ programming language with the OpenGL graphics packages. The Linux operational system was adopted with the goal of running it in an open source platform and free access. Preliminary simulation results for a cerebral tumor case will be reported as well as some dosimetric evaluations. (author)

  3. Development of a stereolithography (STL) input and computer numerical control (CNC) output algorithm for an entry-level 3-D printer

    OpenAIRE

    Brown, Andrew; De Beer, Deon; Conradie, Pieter

    2014-01-01

    This paper presents a prototype Stereolithography (STL) file format slicing and tool-path generation algorithm, which serves as a data front-end for a Rapid Prototyping (RP) entry- level three-dimensional (3-D) printer. Used mainly in Additive Manufacturing (AM), 3-D printers are devices that apply plastic, ceramic, and metal, layer by layer, in all three dimensions on a flat surface (X, Y, and Z axis). 3-D printers, unfortunately, cannot print an object without a special algorithm that is re...

  4. FastScript3D - A Companion to Java 3D

    Science.gov (United States)

    Koenig, Patti

    2005-01-01

    FastScript3D is a computer program, written in the Java 3D(TM) programming language, that establishes an alternative language that helps users who lack expertise in Java 3D to use Java 3D for constructing three-dimensional (3D)-appearing graphics. The FastScript3D language provides a set of simple, intuitive, one-line text-string commands for creating, controlling, and animating 3D models. The first word in a string is the name of a command; the rest of the string contains the data arguments for the command. The commands can also be used as an aid to learning Java 3D. Developers can extend the language by adding custom text-string commands. The commands can define new 3D objects or load representations of 3D objects from files in formats compatible with such other software systems as X3D. The text strings can be easily integrated into other languages. FastScript3D facilitates communication between scripting languages [which enable programming of hyper-text markup language (HTML) documents to interact with users] and Java 3D. The FastScript3D language can be extended and customized on both the scripting side and the Java 3D side.

  5. Computational analysis for antimicrobial active pyrano[2,3-d]pyrimidine derivatives on the basis of theoretical and experimental ground

    Directory of Open Access Journals (Sweden)

    Ajmal R. Bhat

    2016-06-01

    Full Text Available Annulated pyrano[2,3-d]pyrimidine derivatives were synthesized with methoxy, hydroxyl, nitrile and bromine substituents in its skeleton and correlated by electronic effect of substituents on the magnitude of antimicrobial activity. The different electron donating and electron withdrawing substituents of the pyrano[2,3-d]pyrimidine derivatives exerted positive influence on its antimicrobial activity against some Gram positive and Gram negative bacteria such as, Bacillus cereus, Staphylococcus aureus, Klebsiella pneumonia, Pseudomonas aureus and Escherichia coli, respectively. Antibacterial screening revealed that the presence of heteroaryl, cyano and amino groups on pyrano[2,3-d]pyrimidine skeleton increases its penetrating power on bacterial cell wall and becomes more biologically active. All the pyrano[2,3-d]pyrimidine derivatives were characterized by IR, 1H NMR, 13C NMR and mass spectra.

  6. REVIEW OF THE GOVERNING EQUATIONS, COMPUTATIONAL ALGORITHMS, AND OTHER COMPONENTS OF THE MODELS-3 COMMUNITY MULTISCALE AIR QUALITY (CMAQ) MODELING SYSTEM

    Science.gov (United States)

    This article describes the governing equations, computational algorithms, and other components entering into the Community Multiscale Air Quality (CMAQ) modeling system. This system has been designed to approach air quality as a whole by including state-of-the-science capabiliti...

  7. Microfluidic 3D Helix Mixers

    Directory of Open Access Journals (Sweden)

    Georgette B. Salieb-Beugelaar

    2016-10-01

    Full Text Available Polymeric microfluidic systems are well suited for miniaturized devices with complex functionality, and rapid prototyping methods for 3D microfluidic structures are increasingly used. Mixing at the microscale and performing chemical reactions at the microscale are important applications of such systems and we therefore explored feasibility, mixing characteristics and the ability to control a chemical reaction in helical 3D channels produced by the emerging thread template method. Mixing at the microscale is challenging because channel size reduction for improving solute diffusion comes at the price of a reduced Reynolds number that induces a strictly laminar flow regime and abolishes turbulence that would be desired for improved mixing. Microfluidic 3D helix mixers were rapidly prototyped in polydimethylsiloxane (PDMS using low-surface energy polymeric threads, twisted to form 2-channel and 3-channel helices. Structure and flow characteristics were assessed experimentally by microscopy, hydraulic measurements and chromogenic reaction, and were modeled by computational fluid dynamics. We found that helical 3D microfluidic systems produced by thread templating allow rapid prototyping, can be used for mixing and for controlled chemical reaction with two or three reaction partners at the microscale. Compared to the conventional T-shaped microfluidic system used as a control device, enhanced mixing and faster chemical reaction was found to occur due to the combination of diffusive mixing in small channels and flow folding due to the 3D helix shape. Thus, microfluidic 3D helix mixers can be rapidly prototyped using the thread template method and are an attractive and competitive method for fluid mixing and chemical reactions at the microscale.

  8. A Novel Method to Verify Multilevel Computational Models of Biological Systems Using Multiscale Spatio-Temporal Meta Model Checking.

    Science.gov (United States)

    Pârvu, Ovidiu; Gilbert, David

    2016-01-01

    Insights gained from multilevel computational models of biological systems can be translated into real-life applications only if the model correctness has been verified first. One of the most frequently employed in silico techniques for computational model verification is model checking. Traditional model checking approaches only consider the evolution of numeric values, such as concentrations, over time and are appropriate for computational models of small scale systems (e.g. intracellular networks). However for gaining a systems level understanding of how biological organisms function it is essential to consider more complex large scale biological systems (e.g. organs). Verifying computational models of such systems requires capturing both how numeric values and properties of (emergent) spatial structures (e.g. area of multicellular population) change over time and across multiple levels of organization, which are not considered by existing model checking approaches. To address this limitation we have developed a novel approximate probabilistic multiscale spatio-temporal meta model checking methodology for verifying multilevel computational models relative to specifications describing the desired/expected system behaviour. The methodology is generic and supports computational models encoded using various high-level modelling formalisms because it is defined relative to time series data and not the models used to generate it. In addition, the methodology can be automatically adapted to case study specific types of spatial structures and properties using the spatio-temporal meta model checking concept. To automate the computational model verification process we have implemented the model checking approach in the software tool Mule (http://mule.modelchecking.org). Its applicability is illustrated against four systems biology computational models previously published in the literature encoding the rat cardiovascular system dynamics, the uterine contractions of labour

  9. A Novel Method to Verify Multilevel Computational Models of Biological Systems Using Multiscale Spatio-Temporal Meta Model Checking.

    Science.gov (United States)

    Pârvu, Ovidiu; Gilbert, David

    2016-01-01

    Insights gained from multilevel computational models of biological systems can be translated into real-life applications only if the model correctness has been verified first. One of the most frequently employed in silico techniques for computational model verification is model checking. Traditional model checking approaches only consider the evolution of numeric values, such as concentrations, over time and are appropriate for computational models of small scale systems (e.g. intracellular networks). However for gaining a systems level understanding of how biological organisms function it is essential to consider more complex large scale biological systems (e.g. organs). Verifying computational models of such systems requires capturing both how numeric values and properties of (emergent) spatial structures (e.g. area of multicellular population) change over time and across multiple levels of organization, which are not considered by existing model checking approaches. To address this limitation we have developed a novel approximate probabilistic multiscale spatio-temporal meta model checking methodology for verifying multilevel computational models relative to specifications describing the desired/expected system behaviour. The methodology is generic and supports computational models encoded using various high-level modelling formalisms because it is defined relative to time series data and not the models used to generate it. In addition, the methodology can be automatically adapted to case study specific types of spatial structures and properties using the spatio-temporal meta model checking concept. To automate the computational model verification process we have implemented the model checking approach in the software tool Mule (http://mule.modelchecking.org). Its applicability is illustrated against four systems biology computational models previously published in the literature encoding the rat cardiovascular system dynamics, the uterine contractions of labour

  10. Optimisation and validation of a 3D reconstruction algorithm for single photon emission computed tomography by means of GATE simulation platform

    International Nuclear Information System (INIS)

    Although time consuming, Monte-Carlo simulations remain an efficient tool enabling to assess correction methods for degrading physical effects in medical imaging. We have optimized and validated a reconstruction method baptized F3DMC (Fully 3D Monte Carlo) in which the physical effects degrading the image formation process were modelled using Monte-Carlo methods and integrated within the system matrix. We used the Monte-Carlo simulation toolbox GATE. We validated GATE in SPECT by modelling the gamma-camera (Philips AXIS) used in clinical routine. Techniques of threshold, filtering by a principal component analysis and targeted reconstruction (functional regions, hybrid regions) were used in order to improve the precision of the system matrix and to reduce the number of simulated photons as well as the time consumption required. The EGEE Grid infrastructures were used to deploy the GATE simulations in order to reduce their computation time. Results obtained with F3DMC were compared with the reconstruction methods (FBP, ML-EM, MLEMC) for a simulated phantom and with the OSEM-C method for the real phantom. Results have shown that the F3DMC method and its variants improve the restoration of activity ratios and the signal to noise ratio. By the use of the grid EGEE, a significant speed-up factor of about 300 was obtained. These results should be confirmed by performing studies on complex phantoms and patients and open the door to a unified reconstruction method, which could be used in SPECT and also in PET. (author)

  11. Hypothesize and Bound: A Computational Focus of Attention Mechanism for Simultaneous 3D Shape Reconstruction, Pose Estimation and Classification from a Single 2D Image

    OpenAIRE

    Rother, Diego; Mahendran, Siddharth; Vidal, René

    2011-01-01

    This article presents a mathematical framework to simultaneously tackle the problems of 3D reconstruction, pose estimation and object classification, from a single 2D image. In sharp contrast with state of the art methods that rely primarily on 2D information and solve each of these three problems separately or iteratively, we propose a mathematical framework that incorporates prior "knowledge" about the 3D shapes of different object classes and solves these problems jointly and simultaneousl...

  12. Cubical Cohomology Ring of 3D Photographs

    CERN Document Server

    Gonzalez-Diaz, Rocio; Medrano, Belen; 10.1002/ima.20271

    2011-01-01

    Cohomology and cohomology ring of three-dimensional (3D) objects are topological invariants that characterize holes and their relations. Cohomology ring has been traditionally computed on simplicial complexes. Nevertheless, cubical complexes deal directly with the voxels in 3D images, no additional triangulation is necessary, facilitating efficient algorithms for the computation of topological invariants in the image context. In this paper, we present formulas to directly compute the cohomology ring of 3D cubical complexes without making use of any additional triangulation. Starting from a cubical complex $Q$ that represents a 3D binary-valued digital picture whose foreground has one connected component, we compute first the cohomological information on the boundary of the object, $\\partial Q$ by an incremental technique; then, using a face reduction algorithm, we compute it on the whole object; finally, applying the mentioned formulas, the cohomology ring is computed from such information.

  13. Computer-assisted system for diagnosing degenerative dementia using cerebral blood flow SPECT and 3D-SSP. A multicenter study

    International Nuclear Information System (INIS)

    Due to increasing numbers of patients with dementia, more physicians who do not specialize in brain nuclear medicine are being asked to interpret SPECT images of cerebral blood flow. We conducted a multicenter study to determine whether a computer-assisted diagnostic system Z-score summation analysis method (ZSAM) using three-dimensional stereotactic surface projections (3D-SSP) can differentiate Alzheimer's disease (AD)/dementia with Lewy bodies (DLB) and non-AD/DLB in institutions using various types of gamma cameras. We determined the normal thresholds of Z-sum (summed Z-score) within a template region of interest for each single photon emission computed tomography (SPECT) device and then compared them with the Z-sums of patients and calculated the accuracy of the differential diagnosis by ZSAM. We compared the diagnostic accuracy between ZSAM and visual assessment. We enrolled 202 patients with AD (mean age, 76.8 years), 40 with DLB (mean age 76.3 years) and 36 with non-AD/DLB (progressive supranuclear palsy, n=10; frontotemporal dementia, n=20; slowly progressive aphasia, n=2 and one each with idiopathic normal pressure hydrocephalus, corticobasal degeneration, multiple system atrophy and Parkinson's disease) who underwent N-isopropyl-p-[123I] iodoamphetamine cerebral blood flow SPECT imaging at each participating institution. The ZSAM sensitivity to differentiate between AD/DLB and non-AD/DLB in all patients, as well as those with mini-mental state examination scores of ≥24 and 20-23 points were 88.0, 78.0 and 88.4%, respectively, with specificity of 50.0, 44.4 and 60.0%, respectively. The diagnostic accuracy rates were 83.1, 72.9 and 84.2%, respectively. The areas under receiver operating characteristics curves for visual inspection by four expert raters were 0.74-0.84, 0.66-0.85 and 0.81-0.93, respectively, in the same patient groups. The diagnostic accuracy rates were 70.9-89.2%, 50.9-84.8% and 76.2-93.1%, respectively. The diagnostic accuracy

  14. Compression of 3D models with NURBS

    OpenAIRE

    Santa Cruz Ducci, Diego; Ebrahimi, Touradj

    2005-01-01

    With recent progress in computing, algorithmics and telecommunications, 3D models are increasingly used in various multimedia applications. Examples include visualization, gaming, entertainment and virtual reality. In the multimedia domain 3D models have been traditionally represented as polygonal meshes. This piecewise planar representation can be thought of as the analogy of bitmap images for 3D surfaces. As bitmap images, they enjoy great flexibility and are particularly well suited to des...

  15. Radiochromic 3D Detectors

    Science.gov (United States)

    Oldham, Mark

    2015-01-01

    Radiochromic materials exhibit a colour change when exposed to ionising radiation. Radiochromic film has been used for clinical dosimetry for many years and increasingly so recently, as films of higher sensitivities have become available. The two principle advantages of radiochromic dosimetry include greater tissue equivalence (radiologically) and the lack of requirement for development of the colour change. In a radiochromic material, the colour change arises direct from ionising interactions affecting dye molecules, without requiring any latent chemical, optical or thermal development, with important implications for increased accuracy and convenience. It is only relatively recently however, that 3D radiochromic dosimetry has become possible. In this article we review recent developments and the current state-of-the-art of 3D radiochromic dosimetry, and the potential for a more comprehensive solution for the verification of complex radiation therapy treatments, and 3D dose measurement in general.

  16. 3D Projection Installations

    DEFF Research Database (Denmark)

    Halskov, Kim; Johansen, Stine Liv; Bach Mikkelsen, Michelle

    2014-01-01

    Three-dimensional projection installations are particular kinds of augmented spaces in which a digital 3-D model is projected onto a physical three-dimensional object, thereby fusing the digital content and the physical object. Based on interaction design research and media studies, this article...... contributes to the understanding of the distinctive characteristics of such a new medium, and identifies three strategies for designing 3-D projection installations: establishing space; interplay between the digital and the physical; and transformation of materiality. The principal empirical case, From...... Fingerplan to Loop City, is a 3-D projection installation presenting the history and future of city planning for the Copenhagen area in Denmark. The installation was presented as part of the 12th Architecture Biennale in Venice in 2010....

  17. 3-D simulation of transient flow patterns in a corridor-shaped air-cushion surge chamber based on computational fluid dynamics

    Institute of Scientific and Technical Information of China (English)

    XIA Lin-sheng; CHENG Yong-guang; ZHOU Da-qing

    2013-01-01

    The 3-D characteristics of the water-air flow patterns in a corridor-shaped air-cushion surge chamber during hydraulic transients need to be considered in the shape optimization.To verify the reliability of the water-air two-phase model,namely,the volume of fluid model,the process of charging water into a closed air chamber is successfully simulated.Using the model,the 3-D flow characteristics under the load rejection and acceptance conditions within the air-cushion surge chamber of a specific hydropower station are studied.The flee surface waves,the flow patterns,and the pressure changes during the surge wave process are analyzed in detail.The longitudinal flow of water in the long corridor-shaped surge chamber is similar to the open channel flow with respect to the wave propagation,reflection and superposition characteristics.The lumped parameters of the 3-D numerical simulation agree with the results of a 1-D calculation of hydraulic transients in the whole water conveying system,which validates the 3-D method.The 3-D flow structures obtained can be applied to the shape optimization of the chamber.

  18. Herramientas SIG 3D

    Directory of Open Access Journals (Sweden)

    Francisco R. Feito Higueruela

    2010-04-01

    Full Text Available Applications of Geographical Information Systems on several Archeology fields have been increasing during the last years. Recent avances in these technologies make possible to work with more realistic 3D models. In this paper we introduce a new paradigm for this system, the GIS Thetrahedron, in which we define the fundamental elements of GIS, in order to provide a better understanding of their capabilities. At the same time the basic 3D characteristics of some comercial and open source software are described, as well as the application to some samples on archeological researchs

  19. TOWARDS: 3D INTERNET

    OpenAIRE

    Ms. Swapnali R. Ghadge

    2013-01-01

    In today’s ever-shifting media landscape, it can be a complex task to find effective ways to reach your desired audience. As traditional media such as television continue to lose audience share, one venue in particular stands out for its ability to attract highly motivated audiences and for its tremendous growth potential the 3D Internet. The concept of '3D Internet' has recently come into the spotlight in the R&D arena, catching the attention of many people, and leading to a lot o...

  20. Interaktiv 3D design

    DEFF Research Database (Denmark)

    Villaume, René Domine; Ørstrup, Finn Rude

    2002-01-01

    Projektet undersøger potentialet for interaktiv 3D design via Internettet. Arkitekt Jørn Utzons projekt til Espansiva blev udviklet som et byggesystem med det mål, at kunne skabe mangfoldige planmuligheder og mangfoldige facade- og rumudformninger. Systemets bygningskomponenter er digitaliseret som...... 3D elementer og gjort tilgængelige. Via Internettet er det nu muligt at sammenstille og afprøve en uendelig  række bygningstyper som  systemet blev tænkt og udviklet til....

  1. A new submodelling technique for multi-scale finite element computation of electromagnetic fields: Application in bioelectromagnetism

    Energy Technology Data Exchange (ETDEWEB)

    Aristovich, K Y; Khan, S H, E-mail: kirill.aristovich.1@city.ac.u [School of Engineering and Mathematical Sciences, City University London, Northampton Square, London EC1V 0HB (United Kingdom)

    2010-07-01

    Complex multi-scale Finite Element (FE) analyses always involve high number of elements and therefore require very long time of computations. This is caused by the fact, that considered effects on smaller scales have greater influences on the whole model and larger scales. Thus, mesh density should be as high as required by the smallest scale factor. New submodelling routine has been developed to sufficiently decrease the time of computation without loss of accuracy for the whole solution. The presented approach allows manipulation of different mesh sizes on different scales and, therefore total optimization of mesh density on each scale and transfer results automatically between the meshes corresponding to respective scales of the whole model. Unlike classical submodelling routine, the new technique operates with not only transfer of boundary conditions but also with volume results and transfer of forces (current density load in case of electromagnetism), which allows the solution of full Maxwell's equations in FE space. The approach was successfully implemented for electromagnetic solution in the forward problem of Magnetic Field Tomography (MFT) based on Magnetoencephalography (MEG), where the scale of one neuron was considered as the smallest and the scale of whole-brain model as the largest. The time of computation was reduced about 100 times, with the initial requirements of direct computations without submodelling routine of 10 million elements.

  2. 3-D Rat Brain Phantom for High-Resolution Molecular Imaging: Experimental studies aimed at advancing understanding of human brain disease and malfunction, and of behavior problems, may be aided by computer models of small laboratory animals

    NARCIS (Netherlands)

    Beekman, F.J.; Vastenhouw, B.; Van der Wilt, G.; Vervloet, M.; Visscher, R.; Booij, J.; Gerrits, M.; Ji, C.; Ramakers, R.; Van der Have, F.

    2009-01-01

    With the steadily improving resolution of novel small-animal single photon emission computed tomography (SPECT) and positron emission tomography devices, highly detailed phantoms are required for testing and optimizing these systems. We present a three-dimensional (3-D) digital and physical phantom

  3. DRACCAR, a new 3D-thermal mechanical computer code to simulate LOCA transient on nuclear power plants. Status of the development and the validation

    International Nuclear Information System (INIS)

    IRSN is developing the DRACCAR computational software within the scope of its safety analyses on pressurised water reactors (PWR). This software is used to study loss-of-coolant accidents in the reactor core (LOCA) or in a spent fuel storage tank, for example. During such an accident, the coolant vaporises and the fuel rods dry out, which leads to an increase of their temperature, a swelling and fuel cladding failure. This swelling is responsible for major blockage in port of the core and can jeopardize the possibility of core cooling by means of back-up systems. The 3D multi-rod software is designed to model a fuel assembly so as to assess rod cooling and the blockage rate caused by deformed rods, by taking into account mechanical and thermal interactions between rods. The software can provide a consistent interpretation of the entire experimental database for a 'single-rod' configuration or a 'rod-bundle' configuration with either real or simulator fuel, transpose these results onto a reactor scale to determine what kind of research still needs to be conducted and finally, carry out safety studies. The models developed for this software cover: Heat transfers by conduction, convection and radiation. Oxidation of Zircaloy elements (cladding, guide tubes, inner shroud layer..) as well as hydriding process which can change mechanical properties. Thermomechanical behavior of fuel cladding (deformation and failure), including bowing phenomenon. Thermohydraulics on the scale of an assembly (to couple with an appropriate software), including a reflooding model. Fuel relocation and release of fission gases. A first version (DRACCAR V1) was delivered in March 2008 and is being validated on the basis of available experimental data (EDGAR, PHEBUS LOCA, PERICLES, REBEKA, HALDEN, etc.). A second version will be released in 2012 for which a coupling, in particular in the frame of the European NURISP project, is planned to an advanced sub-channel thermal-hydraulics code CATHARE

  4. Tangible 3D Modelling

    DEFF Research Database (Denmark)

    Hejlesen, Aske K.; Ovesen, Nis

    2012-01-01

    This paper presents an experimental approach to teaching 3D modelling techniques in an Industrial Design programme. The approach includes the use of tangible free form models as tools for improving the overall learning. The paper is based on lecturer and student experiences obtained through facil...

  5. 3D Harmonic Echocardiography:

    NARCIS (Netherlands)

    M.M. Voormolen

    2007-01-01

    textabstractThree dimensional (3D) echocardiography has recently developed from an experimental technique in the ’90 towards an imaging modality for the daily clinical practice. This dissertation describes the considerations, implementation, validation and clinical application of a unique

  6. 3D Printable Graphene Composite.

    Science.gov (United States)

    Wei, Xiaojun; Li, Dong; Jiang, Wei; Gu, Zheming; Wang, Xiaojuan; Zhang, Zengxing; Sun, Zhengzong

    2015-07-08

    In human being's history, both the Iron Age and Silicon Age thrived after a matured massive processing technology was developed. Graphene is the most recent superior material which could potentially initialize another new material Age. However, while being exploited to its full extent, conventional processing methods fail to provide a link to today's personalization tide. New technology should be ushered in. Three-dimensional (3D) printing fills the missing linkage between graphene materials and the digital mainstream. Their alliance could generate additional stream to push the graphene revolution into a new phase. Here we demonstrate for the first time, a graphene composite, with a graphene loading up to 5.6 wt%, can be 3D printable into computer-designed models. The composite's linear thermal coefficient is below 75 ppm·°C(-1) from room temperature to its glass transition temperature (Tg), which is crucial to build minute thermal stress during the printing process.

  7. Automatic 3D video format detection

    Science.gov (United States)

    Zhang, Tao; Wang, Zhe; Zhai, Jiefu; Doyen, Didier

    2011-03-01

    Many 3D formats exist and will probably co-exist for a long time even if 3D standards are today under definition. The support for multiple 3D formats will be important for bringing 3D into home. In this paper, we propose a novel and effective method to detect whether a video is a 3D video or not, and to further identify the exact 3D format. First, we present how to detect those 3D formats that encode a pair of stereo images into a single image. The proposed method detects features and establishes correspondences between features in the left and right view images, and applies the statistics from the distribution of the positional differences between corresponding features to detect the existence of a 3D format and to identify the format. Second, we present how to detect the frame sequential 3D format. In the frame sequential 3D format, the feature points are oscillating from frame to frame. Similarly, the proposed method tracks feature points over consecutive frames, computes the positional differences between features, and makes a detection decision based on whether the features are oscillating. Experiments show the effectiveness of our method.

  8. Computer-assisted solid lung nodule 3D volumetry on CT : influence of scan mode and iterative reconstruction: a CT phantom study

    NARCIS (Netherlands)

    Coenen, Adriaan; Honda, Osamu; van der Jagt, Eric J.; Tomiyama, Noriyuki

    2013-01-01

    To evaluate the effect of high-resolution scan mode and iterative reconstruction on lung nodule 3D volumetry. Solid nodules with various sizes (5, 8, 10 and 12 mm) were placed inside a chest phantom. CT images were obtained with various tube currents, scan modes (conventional mode, high-resolution m

  9. Analytic and Computational Perspectives of Multi-Scale Theory for Homogeneous, Laminated Composite, and Sandwich Beams and Plates

    Science.gov (United States)

    Tessler, Alexander; Gherlone, Marco; Versino, Daniele; DiSciuva, Marco

    2012-01-01

    This paper reviews the theoretical foundation and computational mechanics aspects of the recently developed shear-deformation theory, called the Refined Zigzag Theory (RZT). The theory is based on a multi-scale formalism in which an equivalent single-layer plate theory is refined with a robust set of zigzag local layer displacements that are free of the usual deficiencies found in common plate theories with zigzag kinematics. In the RZT, first-order shear-deformation plate theory is used as the equivalent single-layer plate theory, which represents the overall response characteristics. Local piecewise-linear zigzag displacements are used to provide corrections to these overall response characteristics that are associated with the plate heterogeneity and the relative stiffnesses of the layers. The theory does not rely on shear correction factors and is equally accurate for homogeneous, laminated composite, and sandwich beams and plates. Regardless of the number of material layers, the theory maintains only seven kinematic unknowns that describe the membrane, bending, and transverse shear plate-deformation modes. Derived from the virtual work principle, RZT is well-suited for developing computationally efficient, C(sup 0)-continuous finite elements; formulations of several RZT-based elements are highlighted. The theory and its finite element approximations thus provide a unified and reliable computational platform for the analysis and design of high-performance load-bearing aerospace structures.

  10. DYNA3D2000*, Explicit 3-D Hydrodynamic FEM Program

    International Nuclear Information System (INIS)

    1 - Description of program or function: DYNA3D2000 is a nonlinear explicit finite element code for analyzing 3-D structures and solid continuum. The code is vectorized and available on several computer platforms. The element library includes continuum, shell, beam, truss and spring/damper elements to allow maximum flexibility in modeling physical problems. Many materials are available to represent a wide range of material behavior, including elasticity, plasticity, composites, thermal effects and rate dependence. In addition, DYNA3D has a sophisticated contact interface capability, including frictional sliding, single surface contact and automatic contact generation. 2 - Method of solution: Discretization of a continuous model transforms partial differential equations into algebraic equations. A numerical solution is then obtained by solving these algebraic equations through a direct time marching scheme. 3 - Restrictions on the complexity of the problem: Recent software improvements have eliminated most of the user identified limitations with dynamic memory allocation and a very large format description that has pushed potential problem sizes beyond the reach of most users. The dominant restrictions remain in code execution speed and robustness, which the developers constantly strive to improve

  11. Multiscale full waveform inversion

    Science.gov (United States)

    Fichtner, Andreas; Trampert, Jeannot; Cupillard, Paul; Saygin, Erdinc; Taymaz, Tuncay; Capdeville, Yann; Villaseñor, Antonio

    2013-07-01

    We develop and apply a full waveform inversion method that incorporates seismic data on a wide range of spatio-temporal scales, thereby constraining the details of both crustal and upper-mantle structure. This is intended to further our understanding of crust-mantle interactions that shape the nature of plate tectonics, and to be a step towards improved tomographic models of strongly scale-dependent earth properties, such as attenuation and anisotropy. The inversion for detailed regional earth structure consistently embedded within a large-scale model requires locally refined numerical meshes that allow us to (1) model regional wave propagation at high frequencies, and (2) capture the inferred fine-scale heterogeneities. The smallest local grid spacing sets the upper bound of the largest possible time step used to iteratively advance the seismic wave field. This limitation leads to extreme computational costs in the presence of fine-scale structure, and it inhibits the construction of full waveform tomographic models that describe earth structure on multiple scales. To reduce computational requirements to a feasible level, we design a multigrid approach based on the decomposition of a multiscale earth model with widely varying grid spacings into a family of single-scale models where the grid spacing is approximately uniform. Each of the single-scale models contains a tractable number of grid points, which ensures computational efficiency. The multi-to-single-scale decomposition is the foundation of iterative, gradient-based optimization schemes that simultaneously and consistently invert data on all scales for one multi-scale model. We demonstrate the applicability of our method in a full waveform inversion for Eurasia, with a special focus on Anatolia where coverage is particularly dense. Continental-scale structure is constrained by complete seismic waveforms in the 30-200 s period range. In addition to the well-known structural elements of the Eurasian mantle

  12. 3D background aerodynamics using CFD

    DEFF Research Database (Denmark)

    Sørensen, Niels N.

    2002-01-01

    3D rotor computations for the Greek Geovilogiki (GEO) 44 meter rotor equipped with 19 meters blades are performed. The lift and drag polars are extracted at five spanvise locations r/R= (.37, .55, .71, .82, .93) based on identification of stagnationpoints between 2D and 3D computations. The inner...... most sections shows clear evidence of 3D radial pumping, with increased lift compared to 2D values. In contrast to earlier investigated airfoils a very limited impact on the drag values are observed....

  13. Virtual 3-D Facial Reconstruction

    Directory of Open Access Journals (Sweden)

    Martin Paul Evison

    2000-06-01

    Full Text Available Facial reconstructions in archaeology allow empathy with people who lived in the past and enjoy considerable popularity with the public. It is a common misconception that facial reconstruction will produce an exact likeness; a resemblance is the best that can be hoped for. Research at Sheffield University is aimed at the development of a computer system for facial reconstruction that will be accurate, rapid, repeatable, accessible and flexible. This research is described and prototypical 3-D facial reconstructions are presented. Interpolation models simulating obesity, ageing and ethnic affiliation are also described. Some strengths and weaknesses in the models, and their potential for application in archaeology are discussed.

  14. On a multiscale strategy and its optimization for the simulation of combined delamination and buckling

    CERN Document Server

    Saavedra, Karin; Gosselet, Pierre; 10.1002/nme.4305

    2012-01-01

    This paper investigates a computational strategy for studying the interactions between multiple through-the-width delaminations and global or local buckling in composite laminates taking into account possible contact between the delaminated surfaces. In order to achieve an accurate prediction of the quasi-static response, a very refined discretization of the structure is required, leading to the resolution of very large and highly nonlinear numerical problems. In this paper, a nonlinear finite element formulation along with a parallel iterative scheme based on a multiscale domain decomposition are used for the computation of 3D mesoscale models. Previous works by the authors already dealt with the simulation of multiscale delamination assuming small perturbations. This paper presents the formulation used to include geometric nonlinearities into this existing multiscale framework and discusses the adaptations that need to be made to the iterative process in order to ensure the rapid convergence and the scalabi...

  15. Computer-Aided Designing and Manufacturing of Lingual Fixed Orthodontic Appliance Using 2D/3D Registration Software and Rapid Prototyping

    Directory of Open Access Journals (Sweden)

    Soon-Yong Kwon

    2014-01-01

    Full Text Available The availability of 3D dental model scanning technology, combined with the ability to register CBCT data with digital models, has enabled the fabrication of orthognathic surgical CAD/CAM designed splints, customized brackets, and indirect bonding systems. In this study, custom lingual orthodontic appliances were virtually designed by merging 3D model images with lateral and posterior-anterior cephalograms. By exporting design information to 3D CAD software, we have produced a stereolithographic prototype and converted it into a cobalt-chrome alloy appliance as a way of combining traditional prosthetic investment and cast techniques. While the bonding procedure of the appliance could be reinforced, CAD technology simplified the fabrication process by eliminating the soldering phase. This report describes CAD/CAM fabrication of the complex anteroposterior lingual bonded retraction appliance for intrusive retraction of the maxillary anterior dentition. Furthermore, the CAD/CAM method eliminates the extra step of determining the lever arm on the lateral cephalograms and subsequent design modifications on the study model.

  16. Computer-Aided Designing and Manufacturing of Lingual Fixed Orthodontic Appliance Using 2D/3D Registration Software and Rapid Prototyping.

    Science.gov (United States)

    Kwon, Soon-Yong; Kim, Yong; Ahn, Hyo-Won; Kim, Ki-Beom; Chung, Kyu-Rhim; Kim Sunny, Seong-Hun

    2014-01-01

    The availability of 3D dental model scanning technology, combined with the ability to register CBCT data with digital models, has enabled the fabrication of orthognathic surgical CAD/CAM designed splints, customized brackets, and indirect bonding systems. In this study, custom lingual orthodontic appliances were virtually designed by merging 3D model images with lateral and posterior-anterior cephalograms. By exporting design information to 3D CAD software, we have produced a stereolithographic prototype and converted it into a cobalt-chrome alloy appliance as a way of combining traditional prosthetic investment and cast techniques. While the bonding procedure of the appliance could be reinforced, CAD technology simplified the fabrication process by eliminating the soldering phase. This report describes CAD/CAM fabrication of the complex anteroposterior lingual bonded retraction appliance for intrusive retraction of the maxillary anterior dentition. Furthermore, the CAD/CAM method eliminates the extra step of determining the lever arm on the lateral cephalograms and subsequent design modifications on the study model.

  17. Multi-scale computational model of three-dimensional hemodynamics within a deformable full-body arterial network

    International Nuclear Information System (INIS)

    In this article, we present a computational multi-scale model of fully three-dimensional and unsteady hemodynamics within the primary large arteries in the human. Computed tomography image data from two different patients were used to reconstruct a nearly complete network of the major arteries from head to foot. A linearized coupled-momentum method for fluid–structure-interaction was used to describe vessel wall deformability and a multi-domain method for outflow boundary condition specification was used to account for the distal circulation. We demonstrated that physiologically realistic results can be obtained from the model by comparing simulated quantities such as regional blood flow, pressure and flow waveforms, and pulse wave velocities to known values in the literature. We also simulated the impact of age-related arterial stiffening on wave propagation phenomena by progressively increasing the stiffness of the central arteries and found that the predicted effects on pressure amplification and pulse wave velocity are in agreement with findings in the clinical literature. This work demonstrates the feasibility of three-dimensional techniques for simulating hemodynamics in a full-body compliant arterial network

  18. Multi-scale computational model of three-dimensional hemodynamics within a deformable full-body arterial network

    Energy Technology Data Exchange (ETDEWEB)

    Xiao, Nan [Department of Bioengineering, Stanford University, Stanford, CA 94305 (United States); Department of Biomedical Engineering, King’s College London, London SE1 7EH (United Kingdom); Humphrey, Jay D. [Department of Biomedical Engineering, Yale University, New Haven, CT 06520 (United States); Figueroa, C. Alberto, E-mail: alberto.figueroa@kcl.ac.uk [Department of Biomedical Engineering, King’s College London, London SE1 7EH (United Kingdom)

    2013-07-01

    In this article, we present a computational multi-scale model of fully three-dimensional and unsteady hemodynamics within the primary large arteries in the human. Computed tomography image data from two different patients were used to reconstruct a nearly complete network of the major arteries from head to foot. A linearized coupled-momentum method for fluid–structure-interaction was used to describe vessel wall deformability and a multi-domain method for outflow boundary condition specification was used to account for the distal circulation. We demonstrated that physiologically realistic results can be obtained from the model by comparing simulated quantities such as regional blood flow, pressure and flow waveforms, and pulse wave velocities to known values in the literature. We also simulated the impact of age-related arterial stiffening on wave propagation phenomena by progressively increasing the stiffness of the central arteries and found that the predicted effects on pressure amplification and pulse wave velocity are in agreement with findings in the clinical literature. This work demonstrates the feasibility of three-dimensional techniques for simulating hemodynamics in a full-body compliant arterial network.

  19. Massive 3D Supergravity

    CERN Document Server

    Andringa, Roel; de Roo, Mees; Hohm, Olaf; Sezgin, Ergin; Townsend, Paul K

    2009-01-01

    We construct the N=1 three-dimensional supergravity theory with cosmological, Einstein-Hilbert, Lorentz Chern-Simons, and general curvature squared terms. We determine the general supersymmetric configuration, and find a family of supersymmetric adS vacua with the supersymmetric Minkowski vacuum as a limiting case. Linearizing about the Minkowski vacuum, we find three classes of unitary theories; one is the supersymmetric extension of the recently discovered `massive 3D gravity'. Another is a `new topologically massive supergravity' (with no Einstein-Hilbert term) that propagates a single (2,3/2) helicity supermultiplet.

  20. Massive 3D supergravity

    Energy Technology Data Exchange (ETDEWEB)

    Andringa, Roel; Bergshoeff, Eric A; De Roo, Mees; Hohm, Olaf [Centre for Theoretical Physics, University of Groningen, Nijenborgh 4, 9747 AG Groningen (Netherlands); Sezgin, Ergin [George and Cynthia Woods Mitchell Institute for Fundamental Physics and Astronomy, Texas A and M University, College Station, TX 77843 (United States); Townsend, Paul K, E-mail: E.A.Bergshoeff@rug.n, E-mail: O.Hohm@rug.n, E-mail: sezgin@tamu.ed, E-mail: P.K.Townsend@damtp.cam.ac.u [Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Wilberforce Road, Cambridge, CB3 0WA (United Kingdom)

    2010-01-21

    We construct the N=1 three-dimensional supergravity theory with cosmological, Einstein-Hilbert, Lorentz Chern-Simons, and general curvature squared terms. We determine the general supersymmetric configuration, and find a family of supersymmetric adS vacua with the supersymmetric Minkowski vacuum as a limiting case. Linearizing about the Minkowski vacuum, we find three classes of unitary theories; one is the supersymmetric extension of the recently discovered 'massive 3D gravity'. Another is a 'new topologically massive supergravity' (with no Einstein-Hilbert term) that propagates a single (2,3/2) helicity supermultiplet.