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Sample records for 2p 3p 5q

  1. Doubly excited 2s2p 1,3p1 resonances in photoionization of helium

    Institute of Scientific and Technical Information of China (English)

    Wan Jian-Jie; Dong Chen-Zhong

    2009-01-01

    The multi-configuration Dirac-Fock (MCDF) method is implemented to study doubly excited 2s2p 1,3P1 resonances of the helium atom and the interference between photoionization and photoexcitation autoionization processes.In order to reproduce the total photoionization sprectra,the excited energies from the ground ls2 1 S0 state to the doubly excited 2s2p 1'3P1 states and the relevant Auger decay rates and widths are calculated in detail. Furthermore,the interference profile determined by the so-called Fano parameters q and p2 is also reproduced. Good agreement is found between the present results and other available theoretical and experimental results. This indeed shows a promising way to investigate the Fano resonances in photoionization of atoms within the MCDF scheme,although there are some discrepancies in the present calculations of the 2s2p 3P1 state.

  2. Controlling the $2p$ Hole Alignment in Neon via the $2s$-$3p$ Fano Resonance

    CERN Document Server

    Heinrich-Josties, Elisabeth; Santra, Robin

    2014-01-01

    We study the state-resolved production of neon ion after resonant photoionization of Ne via the $2s$-$3p$ Fano resonance. We find that by tuning the photon energy across the Fano resonance a surprisingly high control over the alignment of the final $2p$ hole along the polarization direction can be achieved. In this way hole alignments can be created that are otherwise very hard to achieve. The mechanism responsible for this hole alignment is the destructive interference of the direct and indirect (via the autoionizing $2s^{-1}3p$ state) ionization pathways of $2p$. By changing the photon energy the strength of the interference varies and $2p$-hole alignments with ratios up to 19:1 between $2p_0$ and $2p_{\\pm 1}$ holes can be created: an effect normally only encountered in tunnel ionization using strong-field IR pulses. Including spin-orbit interaction does not change the qualitative feature and leads only to a reduction in the alignment by $2/3$. Our study is based on a time-dependent configuration-interactio...

  3. Hyperfine Quenching of the 2s2p 3P0 State of Berylliumlike Ions

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, K T; Chen, M H; Johnson, W R

    2008-03-13

    The hyperfine-induced 2s2p {sup 3}P{sub 0}-2s{sup 2} {sup 1}S{sub 0} transition rate for Be-like {sup 47}Ti{sup 18+} was recently measured in a storage-ring experiment by Schippers et al. [Phys. Rev. Lett. 98, 033001 (2007)]. The measured value of 0.56(3) s{sup -1} is almost 60% larger than the theoretical value of 0.356 s{sup -1} from a multiconfiguration Dirac-Fock calculation by Marques et al. [Phys. Rev. A 47, 929 (1993)]. In this work, we use a large-scale relativistic configuration-interaction method to calculate these hyperfine-induced rates for ions with Z = 6-92. Coherent hyperfine-quenching effects between the 2s2p {sup 1,3}P{sub 1} states are included in a perturbative as well as a radiation damping approach. Contrary to the claims of Marques et al., contributions from the {sup 1}P{sub 1} state are substantial and lead to a hyperfine-induced rate of 0.67 s{sup -1}, in better agreement with, though larger than, the measured value.

  4. Unified interpretation of Hund's first and second rules for 2p and 3p atoms.

    Science.gov (United States)

    Oyamada, Takayuki; Hongo, Kenta; Kawazoe, Yoshiyuki; Yasuhara, Hiroshi

    2010-10-28

    A unified interpretation of Hund's first and second rules for 2p (C, N, O) and 3p (Si, P, S) atoms is given by Hartree-Fock (HF) and multiconfiguration Hartree-Fock (MCHF) methods. Both methods exactly satisfy the virial theorem, in principle, which enables one to analyze individual components of the total energy E(=T+V(en)+V(ee)), where T, V(en), and V(ee) are the kinetic, the electron-nucleus attraction, and the electron-electron repulsion energies, respectively. The correct interpretation for each of the two rules can only be achieved under the condition of the virial theorem 2T+V=0 by investigating how V(en) and V(ee) interplay to attain the lower total potential energy V(=V(en)+V(ee)). The stabilization of the more stable states for all the 2p and 3p atoms is ascribed to a greater V(en) that is caused by contraction of the valence orbitals accompanied with slight expansion of the core orbitals. The contraction of the valence orbitals for the two rules is a consequence of reducing the Hartree screening of the nucleus at short interelectronic distances. The reduced screening in the first rule is due to a greater amount of Fermi hole contributions in the state with the highest total spin-angular momentum S. The reduced screening in the second rule is due to the fact that two valence electrons are more likely to be on opposite sides of the nucleus in the state with the highest total orbital-angular momentum L. For each of the two rules, the inclusion of correlation does not qualitatively change the HF interpretation, but HF overestimates the energy difference ∣ΔE∣ between two levels being compared. The magnitude of the correlation energy is significantly larger for the lower L states than for the higher L states since two valence electrons in the lower L states are less likely to be on opposite sides of the nucleus. The MCHF evaluation of ∣ΔE∣ is in excellent agreement with experiment. The present HF and MCHF calculations demonstrate the above statements

  5. Unified interpretation of Hund's first and second rules for 2p and 3p atoms.

    Science.gov (United States)

    Oyamada, Takayuki; Hongo, Kenta; Kawazoe, Yoshiyuki; Yasuhara, Hiroshi

    2010-10-28

    A unified interpretation of Hund's first and second rules for 2p (C, N, O) and 3p (Si, P, S) atoms is given by Hartree-Fock (HF) and multiconfiguration Hartree-Fock (MCHF) methods. Both methods exactly satisfy the virial theorem, in principle, which enables one to analyze individual components of the total energy E(=T+V(en)+V(ee)), where T, V(en), and V(ee) are the kinetic, the electron-nucleus attraction, and the electron-electron repulsion energies, respectively. The correct interpretation for each of the two rules can only be achieved under the condition of the virial theorem 2T+V=0 by investigating how V(en) and V(ee) interplay to attain the lower total potential energy V(=V(en)+V(ee)). The stabilization of the more stable states for all the 2p and 3p atoms is ascribed to a greater V(en) that is caused by contraction of the valence orbitals accompanied with slight expansion of the core orbitals. The contraction of the valence orbitals for the two rules is a consequence of reducing the Hartree screening of the nucleus at short interelectronic distances. The reduced screening in the first rule is due to a greater amount of Fermi hole contributions in the state with the highest total spin-angular momentum S. The reduced screening in the second rule is due to the fact that two valence electrons are more likely to be on opposite sides of the nucleus in the state with the highest total orbital-angular momentum L. For each of the two rules, the inclusion of correlation does not qualitatively change the HF interpretation, but HF overestimates the energy difference ∣ΔE∣ between two levels being compared. The magnitude of the correlation energy is significantly larger for the lower L states than for the higher L states since two valence electrons in the lower L states are less likely to be on opposite sides of the nucleus. The MCHF evaluation of ∣ΔE∣ is in excellent agreement with experiment. The present HF and MCHF calculations demonstrate the above statements

  6. Electron impact excitation of 2p and 3p states of hydrogen at intermediate energies

    International Nuclear Information System (INIS)

    A coupled-channel-optical (CCO) calculation with 9 and 12 atomic states supplemented with the continuum optical potentials for the stronger coupling channels has been performed for the electron impact excitation of hydrogen. The calculated n = 2 and n = 3 differential cross sections and the reduced Stokes parameters are comparable with the state-of-the art calculations. There is closer agreement between the present calculations and the experimental measurements for the reduced Stokes parameters P-bar1 and P-bar3 in the n = 2p excitation at 54.4 eV. The present CCO calculations also display good accord with the limited experimental data for the reduced Stokes parameters in the n = 3p excitation. (authors)

  7. Phospholipid flippases Lem3p-Dnf1p and Lem3p-Dnf2p are involved in the sorting of the tryptophan permease Tat2p in yeast.

    Science.gov (United States)

    Hachiro, Takeru; Yamamoto, Takaharu; Nakano, Kenji; Tanaka, Kazuma

    2013-02-01

    The type 4 P-type ATPases are flippases that generate phospholipid asymmetry in membranes. In budding yeast, heteromeric flippases, including Lem3p-Dnf1p and Lem3p-Dnf2p, translocate phospholipids to the cytoplasmic leaflet of membranes. Here, we report that Lem3p-Dnf1/2p are involved in transport of the tryptophan permease Tat2p to the plasma membrane. The lem3Δ mutant exhibited a tryptophan requirement due to the mislocalization of Tat2p to intracellular membranes. Tat2p was relocalized to the plasma membrane when trans-Golgi network (TGN)-to-endosome transport was inhibited. Inhibition of ubiquitination by mutations in ubiquitination machinery also rerouted Tat2p to the plasma membrane. Lem3p-Dnf1/2p are localized to endosomal/TGN membranes in addition to the plasma membrane. Endocytosis mutants, in which Lem3p-Dnf1/2p are sequestered to the plasma membrane, also exhibited the ubiquitination-dependent missorting of Tat2p. These results suggest that Tat2p is ubiquitinated at the TGN and missorted to the vacuolar pathway in the lem3Δ mutant. The NH(2)-terminal cytoplasmic region of Tat2p containing ubiquitination acceptor lysines interacted with liposomes containing acidic phospholipids, including phosphatidylserine. This interaction was abrogated by alanine substitution mutations in the basic amino acids downstream of the ubiquitination sites. Interestingly, a mutant Tat2p containing these substitutions was missorted in a ubiquitination-dependent manner. We propose the following model based on these results; Tat2p is not ubiquitinated when the NH(2)-terminal region is bound to membrane phospholipids, but if it dissociates from the membrane due to a low level of phosphatidylserine caused by perturbation of phospholipid asymmetry in the lem3Δ mutant, Tat2p is ubiquitinated and then transported from the TGN to the vacuole.

  8. Influence of relaxation effects on probabilities of the 2s2p3 S2—2s2 2p2 3p1,2intercombination

    Institute of Scientific and Technical Information of China (English)

    袁萍; 刘欣生; 等

    2003-01-01

    Transition probabilities of the 2s2p3 5S2-2s2 2P2 3P1,2 intercombination transitions in NII have been calculated by using a large-scale multiconfiguration Dirac-Fock method.In the calculation themost important effects of relativity,correlation,and relaxation are considered.From the calculated transition probabilities,the lifetime of the s22p3 5S2 metastable state is derived.The result is in excellent agreement agreement with the latest experimental result.In the meantime the influence of anomalously strong relaxation effects on probabilities of the 2s2p3 5S2-2s2 2p2 3P1,2 lines in NII have been found.

  9. Relativistic effects on the hyperfine structures of 2p4(3P)3p 2Do, 4Do and 4Po in 19F I

    OpenAIRE

    Carette, Thomas; Nemouchi, Messaoud; Li, Jiguang; Godefroid, Michel

    2013-01-01

    The hyperfine interaction constants of the 2p4(3P)3p 2Do_{3/2,5/2}, 4Do_{1/2-7/2} and 4Po_{1/2-5/2} levels in neutral fluorine are investigated theoretically. Large-scale calculations are carried out using the multiconfiguration Hartree-Fock (MCHF) and Dirac-Hartree-Fock (MCDHF) methods. In the framework of the MCHF approach, the relativistic effects are taken into account in the Breit-Pauli approximation using non relativistic orbitals. In the fully relativistic approach, the orbitals are op...

  10. Reactions of R(2)P-P(SiMe(3))Li with [(R'(3)P)(2)PtCl(2)]. A general and efficient entry to phosphanylphosphinidene complexes of platinum. Syntheses and structures of [(eta(2)-P=(i)Pr(2))Pt(p-Tol(3)P)(2)], [(eta(2)-P=(t)Bu(2))Pt(p-Tol(3)P)(2)], [{eta(2)-P=(N(i)Pr(2))(2)}Pt(p-Tol(3)P)(2)] and [{(Et(2)PhP)(2)Pt}(2)P(2)].

    Science.gov (United States)

    Domańska-Babul, Wioleta; Chojnacki, Jaroslaw; Matern, Eberhard; Pikies, Jerzy

    2009-01-01

    The reactions of lithium derivatives of diphosphanes R(2)P-P(SiMe(3))Li (R = (t)Bu, (i)Pr, Et(2)N and (i)Pr(2)N) with [(R'(3)P)(2)PtCl(2)] (R'(3)P = Et(3)P, Et(2)PhP, EtPh(2)P and p-Tol(3)P) proceed in a facile manner to afford side-on bonded phosphanylphosphinidene complexes of platinum [(eta(2)-P=R(2))Pt(PR'(3))(2)]. The related reactions of Ph(2)P-P(SiMe(3))Li with [(R'(3)P)(2)PtCl(2)] did not yield [(eta(2)-P=PPh(2))Pt(PR'(3))(2)] and resulted mainly in the formation of [{(R'(3)P)(2)Pt}(2)P(2)], Ph(2)P-PLi-PPh(2), (Me(3)Si)(2)PLi and (Me(3)Si)(3)P. Crystallographic data are reported for the compounds [(eta(2)-P=R(2))Pt(p-Tol(3)P)(2)] (R = (t)Bu, (i)Pr, ((i)Pr(2)N)(2)P) and for [{(Et(2)PhP)(2)Pt}(2)P(2)].

  11. Identification of a rare de novo three-way complex t(5;20;8(q31;p11.2;p21 with microdeletions on 5q31.2, 5q31.3, and 8p23.2 in a patient with hearing loss and global developmental delay: case report

    Directory of Open Access Journals (Sweden)

    Bejjani Bassem A

    2009-01-01

    Full Text Available Abstract Background Complex chromosome rearrangements (CCRs, which involve more than two breakpoints on two or more chromosomes, are uncommon occurrences. Although most CCRs appear balanced at the level of the light microscope, many demonstrate cryptic, submicroscopic imbalances at the translocation breakpoints. Results We report a female with hearing loss and global developmental delay with a complex three-way unbalanced translocation (5;20;8(q31;p11.2;p21 resulting in microdeletions on 5q31.2, 5q31.3, and 8p23.2 identified by karyotyping, microarray analysis and fluorescence in situ hybridization. Discussion The microdeletion of bands 8p23.2 may be associated with the hearing impairment. Furthermore, the characterization of this patient's chromosomal abnormalities demonstrates the importance of integrated technologies within contemporary cytogenetics laboratories.

  12. Transition probabilities for the 3s2 3p(2P0)-3s3p2(4P) intersystem lines of Si II

    Science.gov (United States)

    Calamai, Anthony G.; Smith, Peter L.; Bergeson, S. D.

    1993-01-01

    Intensity ratios of lines of the spin-changing 'intersystem' multiplet of S II (4P yields 2P0) at 234 nm have been used to determine electron densities and temperatures in a variety of astrophysical environments. However, the accuracy of these diagnostic calculations have been limited by uncertainties associated with the available atomic data. We report the first laboratory measurement, using an ion-trapping technique, of the radiative lifetimes of the three metastable levels of the 3s3p2 4P term of Si II. Our results are 104 +/- 16, 406 +/- 33, and 811 +/- 77 micro-s for lifetimes of the J = 1/2, 5/2, and 3/2 levels, respectively. A-values were derived from our lifetimes by use of measured branching fractions. Our A-values, which differ from calculated values by 30 percent or more, should give better agreement between modeled and observed Si II line ratios.

  13. Strong decays of χ{sub cJ}(2P) and χ{sub cJ}(3P)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Hui; Ping, Jialun [Nanjing Normal University and Jiangsu Key Laboratory for Numerical Simulation of Large Scale Complex Systems, Department of Physics, Nanjing (China); Yang, Youchang [Zunyi Normal College, Department of Physics, Zunyi (China)

    2014-04-15

    In the framework of the chiral quark model, the mass spectrum of χ{sub cJ}(J = 0, 1, 2, n = 1, 2, 3) is studied with the Gaussian expansion method. Using the wave functions obtained in the study of mass spectrum, the open charm two-body strong decay widths of these states are calculated by using the {sup 3}P{sub 0} model. The results show that the masses of χ{sub cJ}(1P) and χ{sub c2}(2P) are consistent with the experimental data. But the strong decay width of χ{sub c2}(2P) is three times that of the experimental value. The decay width of χ{sub c1}(2P) is sensitive to its mass. In the quark-antiquark picture, the width is about 385 MeV. However, if the channel coupling effects shift its mass to 3872 MeV, its decay width will be around 1 MeV. The possibility of assigning the state X(3872) as χ{sub c1}(2P) cannot be excluded. To assign X(3915) as χ{sub c0}(2P) is disfavored, due to the unmatching of decay channel. For the χ{sub cJ}(3P) states, no states have been assigned. The possible candidates of χ{sub c0}(3P) are X(4160) and X(4140). Their masses are close to the theoretical ones. The experimental branching ratio of X(4160), Γ (X(4160) → D anti D)/Γ (X(4160) → D* anti D*) < 0.09 is compatible with that of χ{sub c0}(3P), 0.07. However the broad decay width of X(4160) cannot be explained by the open charm two-body decay. To assign X(4140) as χ{sub c0}(3P) is also possible, due to the compatibility of the total decay width, the further measurement of decay modes of X(4140) are expected to justify the assignment. (orig.)

  14. Relativistic effects on the hyperfine structures of 2p4(3P)3p 2Do, 4Do and 4Po in 19F I

    CERN Document Server

    Carette, Thomas; Li, Jiguang; Godefroid, Michel

    2013-01-01

    The hyperfine interaction constants of the 2p4(3P)3p 2Do_{3/2,5/2}, 4Do_{1/2-7/2} and 4Po_{1/2-5/2} levels in neutral fluorine are investigated theoretically. Large-scale calculations are carried out using the multiconfiguration Hartree-Fock (MCHF) and Dirac-Hartree-Fock (MCDHF) methods. In the framework of the MCHF approach, the relativistic effects are taken into account in the Breit-Pauli approximation using non relativistic orbitals. In the fully relativistic approach, the orbitals are optimized using the Dirac-Coulomb Hamiltonian with correlation models inspired by the non relativistic calculations. Higher-order excitations are captured through multireference configuration interaction calculations including the Breit interaction. In a third (intermediate) approach, the Dirac-Coulomb-Breit Hamiltonian matrix is diagonalized in a relativistic configuration space built with non relativistic MCHF radial functions converted into Dirac spinors using the Pauli approximation. The magnetic dipole hyperfine struct...

  15. Measurement of the photoionization cross-section of the 3p{sup 2}P{sub 1/2,3/2} excited levels of sodium

    Energy Technology Data Exchange (ETDEWEB)

    Amin, N.; Mahmood, S.; Anwar-ul-Haq, M.; Riaz, M.; Baig, M.A. [Quaid-i-Azam Univ., Atomic and Molecular Physics Lab., Dept. of Physics, Islamabad (Pakistan)

    2006-01-15

    The photoionization cross-section and number density of the 3p{sup 2}P(1/2,3/2) excited levels of sodium have been measured as a function of the laser energy using two-step laser excitation in conjunction with a thermionic diode working in the space charge limited mode. Employing the saturation technique, the cross-sections for the 3p{sup 2}P(1/2) and 3p{sup 2}P(3/2) levels are determined as 2.16 (43) Mb and 3.74 (74) Mb respectively. (authors)

  16. 2s 2p 3P10 → 2s21S0 intercombination line in beryllium-like krypton, molybdenum and tungsten

    International Nuclear Information System (INIS)

    Transition probabilities are evaluated for the 2s 2p 3P10 → 2s21S0 transition in beryllium-like ions for krypton, molybdenum and tungsten, using configuration-interaction wavefunctions. The importance of the 2s 3p 1P10 configuration is considered

  17. GROUND-STATE OF FERROMAGNETIC NICKEL AND MAGNETIC CIRCULAR-DICHROISM IN 2P AND 3P CORE X-RAY ABSORPTION SPECTROSCOPIES

    NARCIS (Netherlands)

    JO, T; YOSHIDA, A; SAWATZKY, GA

    1992-01-01

    The electronic state of ferromagnetic Ni and an interpretation of magnetic circular dichroism (MCD) in Ni 2p --> 3d and 3p --> 3d X-ray absorption (XAS) are discussed from a viewpoint of 3d configuration interaction. Inclusion of the 3d8 configuration and an orbital-magnetic-moment contribution of 0

  18. Transition probabilities for the 1s21S0-1s2p 3P1 intercombination line in He-like carbon and nitrogen

    International Nuclear Information System (INIS)

    Lifetime measurements are presented for 1s2p 3Psub(1,2) levels for He-like C V and N VI. From the measured lifetimes, transition probabilities are deduced for both allowed and spin-forbidden transitions. The values for the 1s21S0 - 1s2p 3P1 transition rates, 0.29 . 108 and 1.38 . 108 s-1 for C V and N VI respectively, are found to be in good agreement with theory. (orig.)

  19. Measurement of the 1s2s 1S0-1s2p 3P1 intercombination interval in helium-like silicon.

    Science.gov (United States)

    Redshaw, M; Myers, E G

    2002-01-14

    Using Doppler-tuned fast-beam laser spectroscopy the 1s2s 1S0-1s2p 3P1 intercombination interval in 28Si12+ has been measured to be 7230.5(2) cm(-1). The experiment made use of a single-frequency Nd:YAG (1.319 microm) laser and a high-finesse optical buildup cavity. The result provides a precision test of modern relativistic and QED atomic theory. PMID:11801009

  20. Note on the 2s21So-2s2p 3P1 intercombination line of B II and C III

    International Nuclear Information System (INIS)

    Revised transition rates are reported for the 2s21S0-2s2p 3P1 intercombination line of 10.27 ± 0.20 s-1 for B II and 103.0 ± 0.4 s-1 for C III. These MCHF values are based on calculations that correct an error in the spin-other-orbit interaction of previous results and apply the most recent techniques for normalizing Breit-Pauli results for intercombination lines and estimating uncertainties. (orig.)

  1. Improved measurement of the 1s2s 1S0-1s2p 3P1 interval in heliumlike silicon.

    Science.gov (United States)

    DeVore, Thomas R; Crosby, David N; Myers, Edmund G

    2008-06-20

    Using colinear fast-beam laser spectroscopy with copropagating and counter-propagating beams we have measured the 1s2s 1S0-1s2p 3P1 intercombination interval in 28Si12+ with the result 7230.585(6) cm{-1}. The experiment made use of a dual-wavelength, high-finesse, power build-up cavity excited by single-frequency lasers at 1319 and 1450 nm. The result will provide a precision test of ab initio relativistic many-body atomic theory at moderate Z. PMID:18643579

  2. Interference effect involving doubly excited states [1s2p](3,1P)3p2 (J=1) in 1s photoionization of neon

    International Nuclear Information System (INIS)

    Within the framework of multiconfiguration Dirac-Fock (MCDF) method, the interference between photoionization and photoexcitation autoionization involving the doubly excited states [1s2p](3,1P)3p2 (J=1) of neon have been studied theoretically. The present results indicate the fine structure of the interference spectra in experiment and show the dominant contribution to the total profile resulting from some individual resonances. Reasonable agreement is found between the present calculations and other available theoretical and experimental results. In addition, some interesting trends of variation of Fano parameters q and ρ2 have also been pointed out. (author)

  3. Calculation of Electron-Impact 2s22p4 3P2p33s3SO Transition in Atomic Oxygen

    Institute of Scientific and Technical Information of China (English)

    WANG Yang; LI Yan-Hua; ZHOU Ya-Jun

    2005-01-01

    The inelastic scattering of electron from oxygen for the 2s22p4 3P2p33s 3SO transition is studied using the momentum-space coupled channel optical method at 15, 17.5, 20, 22.5, 25, 27.5, 30, 50, and 100eV. Direct ionization cross sections, i.e. differential and integral cross sections, are reported. Important continuum states are included in the coupled channel calculation via a complex equivalent-local optical potential. The present results are compared with the available experimental data and other theoretical calculation results.

  4. Large-scale relativistic configuration-interaction calculation of the 2s21S0--2s2p 3P1 intercombination transition in C III

    International Nuclear Information System (INIS)

    A large-scale, relativistic configuration-interaction (RCI) method has been developed for precision calculations of transition oscillator strengths. It is based on the no-pair Hamiltonian and employs finite B-spline basis functions. For the 2s21S0--2s2p 3P1 intercombination transition in berylliumlike carbon, the present RCI expansions reach close to 200 000 configurations, and include all single and double excitations from valence-valence, core-valence, and core-core interactions, along with dominant triple and quadruple excitations. Resulting length- and velocity-gauge transition rates are very well converged, but still differ by a factor of 2. This strong gauge dependence is found to arise from the neglect of negative-energy states which has negligible effects on length-gauge results but can affect velocity-gauge results significantly. The present intercombination transition rate for C III of 101.6±0.7 sec-1 differs from the measured value of 102.94±0.14 sec-1 [Doerfert , Phys. Rev. Lett. 78, 4355 (1997)] by about 1.3%

  5. Numerical investigation of NeI for 2p55g configuration and ArI for 3p55g configuration Zeeman structure

    International Nuclear Information System (INIS)

    Full text: The behavior of an atom in the magnetic field can be studied numerically based on the parameters of the fine structure (the radial integrals in the energy operator matrix). A set of the fine structure parameters ensuring the correlation with experimentally observed energies was obtained in the previous works of the authors. The authors provide the results of the numerical study of magnetic sublevels behavior for NeI and ArI (of specified configurations) in the magnetic fields up to 150 kOe. Using the free momentums representation and the Clebsch-Gordan coefficients the authors succeeded to obtain the expressions for the diagonal and non-diagonal elements of the atom-field interaction matrices in LSJM-representation as well as to refine the signs of the non-diagonal elements. (γψi|W|γψi) = (((J(J + 1) + L(L + 1) - S (S +1)/2J(J + 1))gl + ((J(J + 1) - L(L + 1) + S (S +1)/2J(J + 1))gs)) μ0H M (ΔJ 0 ΔL = ΔS = 0 ; (γψi|W|γ'ψj) √[((J - L + S + 1)(J + L - S + 1)(J + L + S + 2)(L + S - J))/4(J + 1)2(2J + 1)(2J + 3) x ((J + 1)2 - M2 x (gl - gs)μ0H] (ΔJ 0 ±1, ΔL ΔS = 0, Jmin). The energies of Zeeman's sublevels were calculated by means of the diagonalization of the complete energy operator matrix, which was expressed in LS-representation with additional elements accounting for the atom-field interaction. The diagonalization was carried out for all the values of the magnetic quantum number M. The distinctive details of Zeemann's structure especially points of crossing and anticrossing areas of magnetic sublevels were obtained for 2p55g configuration of NeI and 3p55g configuration of ArI. (author)

  6. Atomic parameters for the 2{p}^{5}3p\\;{}^{2}{[3/2]}_{2}-2{p}^{5}3s\\;{}^{2}{[3/2]}_{2}^{o} transition of Ne I relevant in nuclear physics

    Science.gov (United States)

    Li, Jiguang; Godefroid, Michel; Wang, Jianguo

    2016-06-01

    We calculated the magnetic dipole hyperfine interaction constants and the electric field gradients of 2{p}53p{}2{[3/2]}2 and 2{p}53s{}2[3/2{]}2o levels of Ne I by using the multiconfiguration Dirac–Hartree–Fock method. The electronic factors contributing to the isotope shifts were also estimated for the λ =614.5 {{nm}} transition connecting these two states. Electron correlation and relativistic effects including the Breit interaction were investigated in detail. Combining with recent measurements, we extracted the nuclear quadrupole moment values for 20Ne and 23Ne with a smaller uncertainty than the current available data. Isotope shifts in the 2{p}53p{}2{[3/2]}2-2{p}53s{}2[3/2{]}2o transition based on the present calculated field- and mass-shift parameters are in good agreement with the experimental values. However, the field shifts in this transition are two or three orders of magnitude smaller than the mass shifts, making rather difficult to deduce changes in nuclear-charge mean-square radii. According to our theoretical predictions, we suggest using instead transitions connecting levels arising from the 2p53s configuration to the ground state, for which the normal mass shift and specific mass shift contributions counteract each other, producing relatively small mass shifts that are only one order of magnitude larger than relatively large field shifts, especially for the 2{p}53s{}2[1/2{]}1o-2{p}6{}1{S}0 transition.

  7. Influence of relaxation effects on probabilities of the 2s2p3 5s2-2s22p2 3P1,2 intercombination transitionsin NII

    Institute of Scientific and Technical Information of China (English)

    袁萍; 刘欣生; 颉录有; 张义军; 董晨钟

    2003-01-01

    Transition probabilities of the 2s2p3 5S2-2s22p2 3P1,2 intercombination transitions in NII have been calculated by using a large-scale multiconfiguration Dirac-Fock method. In the calculation the most important effects of relativity,correlation, and relaxation are considered. From the calculated transition probabilities, the lifetime of the 2s2p3 5S2metastable state is derived. The result is in excellent agreement with the latest experimental result. In the meantime the influence of anomalously strong relaxation effects on probabilities of the 2s2p3 5S2-2s22p2 3P1,2 lines in NII have been found.

  8. Multiconfigurational-Dirac-Fock calculation of the 2s21S0--2s2p 3P1 spin-forbidden transition for the Be-like isoelectronic sequence

    International Nuclear Information System (INIS)

    Accurate ab initio multiconfigurational-Dirac-Fock (MCDF) calculations of the lifetimes of the spin-forbidden 2s21S0--2s2p 3P1 transition and the allowed 2s21S0--2s2p 1P1 transition in Be-like ions have been performed. The importance of the inclusion of the Breit interaction to obtain accurate fine-structure splittings and mixing coefficients is discussed and the noted discrepancy between the length and velocity gauges for the intercombination line in the lighter ions is addressed. Different optimization procedures are evaluated. For C III the experimental intercombination transition rate has been measured to be 121.9 s-1 with an accuracy of 6%. The current calculation gives 100.3±4 s-1, in agreement with other recent calculations

  9. Facile aqueous synthesis and electromagnetic properties of novel 3D urchin-like glass/Ni-Ni(3)P/Co(2)P(2)O(7) core/shell/shell composite hollow structures.

    Science.gov (United States)

    An, Zhenguo; Zhang, Jingjie; Pan, Shunlong

    2010-04-14

    Novel 3D urchin-like glass/Ni-Ni(3)P/Co(2)P(2)O(7) core/shell/shell composite hollow structures are fabricated for the first time by controlled stepwise assembly of granular Ni-Ni(3)P alloy and ribbon-like Co(2)P(2)O(7) nanocrystals on hollow glass spheres in aqueous solutions at mild conditions. It is found that the shell structure and the overall morphology of the products can be tailored by properly tuning the annealing temperature. The as-obtained composite core/shell/shell products possess low density (ca. 1.18 g cm(-3)) and shape-dependent magnetic and microwave absorbing properties, and thus may have some promising applications in the fields of low-density magnetic materials, microwave absorbers, etc. Based on a series of contrast experiments, the probable formation mechanism of the core/shell/shell hierarchical structures is proposed. This work provides an additional strategy to prepare core/shell composite spheres with tailored shell morphology and electromagnetic properties. PMID:20379530

  10. Large-scale relativistic configuration-interaction calculation of the 2s{sup 2} {sup 1}S{sub 0}--2s2p {sup 3}P{sub 1} intercombination transition in C III

    Energy Technology Data Exchange (ETDEWEB)

    Chen, M. H.; Cheng, K. T.; Johnson, W. R.

    2001-10-01

    A large-scale, relativistic configuration-interaction (RCI) method has been developed for precision calculations of transition oscillator strengths. It is based on the no-pair Hamiltonian and employs finite B-spline basis functions. For the 2s{sup 2} {sup 1}S{sub 0}--2s2p {sup 3}P{sub 1} intercombination transition in berylliumlike carbon, the present RCI expansions reach close to 200 000 configurations, and include all single and double excitations from valence-valence, core-valence, and core-core interactions, along with dominant triple and quadruple excitations. Resulting length- and velocity-gauge transition rates are very well converged, but still differ by a factor of 2. This strong gauge dependence is found to arise from the neglect of negative-energy states which has negligible effects on length-gauge results but can affect velocity-gauge results significantly. The present intercombination transition rate for C III of 101.6{+-}0.7 sec{sup -1} differs from the measured value of 102.94{+-}0.14 sec{sup -1} [Doerfert , Phys. Rev. Lett. 78, 4355 (1997)] by about 1.3%.

  11. Relativistic evaluation of the two-photon decay of the metastable 1 s22 s 2 p 3P0 state in berylliumlike ions with an effective-potential model

    Science.gov (United States)

    Amaro, Pedro; Fratini, Filippo; Safari, Laleh; Machado, Jorge; Guerra, Mauro; Indelicato, Paul; Santos, José Paulo

    2016-03-01

    The two-photon 1 s22 s 2 p 3P0→1 s2s21S0 transition in berylliumlike ions is investigated theoretically within a fully relativistic framework and a second-order perturbation theory. We focus our analysis on how electron correlation, as well as the negative-energy spectrum, can affect the forbidden E 1 M 1 decay rate. For this purpose, we include the electronic correlation via an effective local potential and within a single-configuration-state model. Due to its experimental interest, evaluations of decay rates are performed for berylliumlike xenon and uranium. We find that the negative-energy contribution can be neglected at the present level of accuracy in the evaluation of the decay rate. On the other hand, if contributions of electronic correlation are not carefully taken into account, it may change the lifetime of the metastable state by up to 20%. By performing a fully relativistic j j -coupling calculation, we find a decrease of the decay rate by two orders of magnitude compared to nonrelativistic L S -coupling calculations, for the selected heavy ions.

  12. Alignment of Ar{sup +} [{sup 3}P]4p{sup 2}P{sup 0}{sub 3/2} satellite state from the polarization analysis of fluorescent radiation after photoionization

    Energy Technology Data Exchange (ETDEWEB)

    Yenen, O.; McLaughlin, K.W.; Jaecks, D.H. [Univ. of Nebraska, Lincoln, NE (United States)] [and others

    1997-04-01

    The measurement of the polarization of radiation from satellite states of Ar{sup +} formed after the photoionization of Ar provides detailed information about the nature of doubly excited states, magnetic sublevel cross sections and partial wave ratios of the photo-ejected electrons. Since the formation of these satellite states is a weak process, it is necessary to use a high flux beam of incoming photons. In addition, in order to resolve the many narrow doubly excited Ar resonances, the incoming photons must have a high resolution. The characteristics of the beam line 9.0.1 of the Advanced Light Source fulfill these requirements. The authors determined the polarization of 4765 {Angstrom} fluorescence from the Ar{sup +} [{sup 3}P] 4p {sup 2}P{sub 3/2}{sup 0} satellite state formed after photoionization of Ar by photons from the 9.0.1 beam line of ALS in the 35.620-38.261 eV energy range using a resolution of approximately 12,700. This is accomplished by measuring the intensities of the fluorescent light polarized parallel (I{parallel}) and perpendicular (I{perpendicular}) to the polarization axis of the incident synchrotron radiation using a Sterling Optics 105MB polarizing filter. The optical system placed at 90{degrees} with respect to the polarization axis of the incident light had a narrow band interference filter ({delta}{lambda}=0.3 nm) to isolate the fluorescent radiation.

  13. Main: 1B5Q [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available 1B5Q トウモロコシ Corn Zea mays L. Polyamine Oxidase Precursor Name=Pao; Zea Mays Molecul...EESRRIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILVPRWWSDRFYKGTFSNWPVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILINCAQKKMCKYHVQGKYD corn_1B5Q.jpg ...

  14. 3p deletion syndrome.

    Science.gov (United States)

    Kaur, Anupam; Khetarpal, S

    2013-08-01

    3p deletion is a rare cytogenetic finding. Here we describe a 3 months old male with congenital malformations. His karyotype revealed 3p deletion 46,XY,del(3)(p25-pter). The child had flexion deformity of wrist and elbow which has never been reported before. PMID:24036645

  15. On the kinetic and thermodynamic fragility of the Pt{sub 60}Cu{sub 16}Co{sub 2}P{sub 22} and Pt{sub 57.3}Cu{sub 14.6}Ni{sub 5.3}P{sub 22.8} bulk metallic glasses

    Energy Technology Data Exchange (ETDEWEB)

    Gallino, Isabella, E-mail: i.gallino@mx.uni-saarland.de [Saarland University, Department of Materials Science and Engineering, Campus C6.3, 66123 Saarbruecken (Germany); Gross, Oliver [Saarland University, Department of Materials Science and Engineering, Campus C6.3, 66123 Saarbruecken (Germany); Dalla Fontana, Giulia [Department of Chemistry IFM and NIS, University of Torino, V. Giuria 7, 10125 Torino (Italy); Evenson, Zach; Busch, Ralf [Saarland University, Department of Materials Science and Engineering, Campus C6.3, 66123 Saarbruecken (Germany)

    2014-12-05

    Highlights: • The studied Pt–Cu–(Ni,Co)–P glasses are more fragile than Zr-based alloys. • They show large increases in the C{sub p} at T{sub g} and small barriers for cooperative rearrangements of atoms. • They have fragility parameters among the lowest reported for BMG systems (D{sup *} = 10–12). • They crystallize into a state that melts with distinctly high entropy of fusion. • The microscopic origin of their fragility seems different than that for Zr- and Pd-based BMGs. - Abstract: The investigations in this study focus on bulk metallic glass (BMG) alloy families based on noble metals like Pt, which are more kinetically fragile than Zr-based BMG systems. Thermophysical properties have been investigated by calorimetry and thermal mechanical analyses for the determination of the specific heat capacity and viscosity, respectively. For the Pt{sub 60}Cu{sub 16}Co{sub 2}P{sub 22} and Pt{sub 57.3}Cu{sub 14.6}Ni{sub 5.3}P{sub 22.8} BMG compositions consistent Vogel–Fulcher–Tammann (VFT) fits of the viscosity measurements are established, and the temperature dependence of the configurational entropy is calculated from thermodynamic data. Fits to the Adam–Gibbs equation are performed using this configurational entropy change. Their fragile nature is compared to that of Zr-based alloys in terms of structural considerations.

  16. SPIN-FORBIDDEN TRANSITIONS FOR BE-LIKE IONS (Z=10-103)%高离化类铍离子2s2 1S0-2s2p3P1(Z=10-103)自旋禁戒光谱跃迁

    Institute of Scientific and Technical Information of China (English)

    易有根; 汪蓉; 李向东; 王红艳; 朱正和

    2000-01-01

    利用全相对论性多组态Dirac-Fock平均能级(MCDF-AL)方法系统地计算了高离化类铍离子自旋禁戒2s2 1S0-2s2p3P1(Z=10-103)跃迁的能级间隔和跃迁概率,计算中考虑了重要的核的有限体积效应,Breit修正和QED修正,所得结果和最近的实验数据及理论计算值进行了比较,结果表明:高原子序数的高荷电离子的自旋禁戒跃迁的跃迁概率和中性原子的电偶极E1的相当,在ICF和MCF高温激光等离子体中,自旋禁戒跃迁概率过程不容被忽视.

  17. P2P financovanie

    OpenAIRE

    Dobiasová, Dana

    2015-01-01

    The aim of this bachelors thesis is to determine the effect of P2P lending on the economic indicators and the status of small and medium enterprises in the United States, specifically for the period form 2011 to 2015. To better understand the practical part, two first chapters will be focused on defining the concept of P2P lending and analysing the current situation in the United States. Besides that, it is also an emphasis on regulatory requirements which are newly starting to appear. This k...

  18. Saperi P2P

    Directory of Open Access Journals (Sweden)

    Salvatore Iaconesi

    2009-10-01

    Full Text Available Il paper presenta l'architettura filosofica e logica di un progetto ongoing per la creazione di un'infrastruttura peer to peer per la diffusione dei saperi. Tale infrastruttura p2p vuole essere la base per costruire un framework aperto e orizzontale, che ospiti pratiche innovative di creazione, condivisione e disseminazione di informazioni e conoscenza.

  19. Duplication of 5q21 in a mildly retarded male and his non-retarded mother

    Energy Technology Data Exchange (ETDEWEB)

    Stallard, R.; Zurcher, V.; Schwartz, S. [Case Western Reserve Univ., Cleveland, OH (United States)

    1994-09-01

    Euchromatic autosomal additions to chromosomal complements are typically associated with global effects including mental retardation (MR) and dysmorphism. We report a familial duplication that does not appear to cause consistent, significant effects. A hyperactive male with mild MR was referred for fra(X) testing at 8 yrs. His karyotype was fra(X) negative and normal except for an addition in one 5q. The abnormal 5 was also in the maternal karyotype, but all other parental chromosomes were normal. The addition (=8.5% the length of a 5) was interpreted as a duplication of band 5q21. FISH with Coatasome 5 (Oncor) showed the addition was from 5. The proband`s karyotype was designated 46,XY,dup(5)(q15q22.1)mat; his mother`s, 46,XX,dup(5)(q15q22.1). Single copy probes are being used to test the cytogenetic interpretation. At 39 yrs, the non-retarded, somewhat inattentive mother, who has a high school diploma and subsequent secretarial courses, cares for the proband and his chromosomally normal, but learning disabled sister at home. The family situation is chaotic with reported paternal psychiatric illness and abuse of the proband and his sister. The mother`s father is dead, but her four younger siblings and mother are reportedly normal. Their chromosomes have not been available. The proband was born at 40 weeks following an uneventful pregnancy, with length and weight at the 5-10th centiles. He walked and talked at about one year. At 9 yrs, his ht/wt ratio was 10th centile. Foot length as <3rd centile; soft masses were present on the anterior ankles. He was otherwise physically normal. His estimated I.Q. was 75 and he was severely hyperactive despite Ritalin. This is the first report of a familial duplication in 5q; no identical, isolated case is known. Although additional family members need evaluation, the presence of the dup(5q) in the non-retarded mother suggests that it may not be associated with the proband`s MR.

  20. Genetic and radiation hybrid mapping of the hyperekplexia region on chromosome 5q.

    OpenAIRE

    Ryan, S. G.; Dixon, M J; Nigro, M A; Kelts, K A; Markand, O N; Terry, J C; Shiang, R; Wasmuth, J J; O'Connell, P

    1992-01-01

    Hyperekplexia, or startle disease (STHE), is an autosomal dominant neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to sudden, unexpected acoustic or tactile stimuli. STHE responds dramatically to the benzodiazepine drug clonazepam, which acts at gamma-aminobutyric acid type A (GABA-A) receptors. The STHE locus (STHE) was recently assigned to chromosome 5q, on the basis of tight...

  1. Distal 5q trisomy resulting from an X;5 translocation detected by chromosome painting.

    Science.gov (United States)

    Abuelo, D N; Ahsanuddin, A N; Mark, H F

    2000-10-23

    We describe the case of a 13-year-old girl with an apparently de novo unbalanced translocation resulting in the presence of additional chromosomal material on the short arm of one X chromosome, which was detected by conventional G-banding studies. Fluorescence in situ hybridization (FISH) using the Chromoprobe Multiprobe-M protocol confirmed that the additional chromosomal material originated from chromosome 5. The karyotype of this patient is now established to be 46,X,der(X) t(X;5)(p22.3;q33), with a deletion of Xp22.3-pter and partial trisomy of 5q33-qter. The distal 5q trisomy genotype has been associated with clinical signs that include growth and mental retardation, eczema, craniofacial anomalies, and malformations of heart, lungs, abdomen, limbs, and genitalia. Our patient also has short stature, a prominent nasal bridge, a flat philtrum, a thin upper lip, dental caries, and limb and cardiac malformations, but she appears to be mildly affected compared with previously reported cases. This is the first case of distal 5q trisomy arising from a translocation with the X chromosome. Replication studies on this patient show that the derivative t(X;5) chromosome is late replicating in almost all cells examined, which indicates that this chromosome is preferentially inactivated. However, the translocated segment of chromosome 5 appears to be early replicating, which implies that the trisomic 5q segment is transcriptionally active. We cannot determine from these studies whether all or only some genes in this segment are expressed, but this patient's relatively mild clinical signs suggest that the critical region(s) that contribute to the distal 5q trisomy phenotype are at least partly suppressed. A review of other patients with X-chromosome translocations indicates that many but not all of them also have attenuated phenotypes. The mechanism of inactivation of autosomal material attached to the X chromosome is complex, with varying effects on the phenotype of the

  2. Multiconfiguration Hartree-Fock Breit-Pauli results for the 2p 2P/sub 1/2/ - 2p 2P/sub 3/2/ E2 and M1 transitions

    International Nuclear Information System (INIS)

    Some forbidden transitions become possible through the fine structure splitting of an LS term into a series of J levels. Examples are the E2 and M1 transition between the 2p 2P/sub 1/2/ and 2p 2P/sub 3/2/ levels in the boron sequence. In the non-relativistic approximation, these levels are degenerate and there is a strong interaction between the 2s22p and 2p32P configurations, indicating important correlation efforts. Thus the theoretical determination of the fine structure splitting provides a sensitive test for a computational method. The MCHF method has been extended to include the relativistic corrections in the Breit-Pauli approximation. An MCHF-BP calculation proceeds in two stages. In the first, a non-relativistic MCHF calculation is performed to determine an orbital basis, whereas in the second the Breit-Pauli interaction matrix is diagonalized. At present the orbit-orbit interactions are neglected. Calculations have been performed with this method for 2p 2P/sub 1/2/ - 2p 2P/sub 3/2/ E2 and M1 transitions of the boron sequence. In order to study the effect of correlation outside the n = 2 complex, two sets of calculations were performed. In the first, the radial orbitals were determined for an MCHF calculation for (2s22p, 2p3) 2P and the Breit-Pauli diagonalization was over the set of four configuration states, (2s22p, 2p32P, 2p32D and 2p34S). In the second, the MCHF calculation was for [2s22p, 2p3, 2p2(1S)3p, 2s24p, 2s2p(1,3P) 3d, 2s3s(3S) 2p] 2P and the Breit-Pauli diagonalization included twenty 2P configuration states, as well as 2p32D and 2p34S, for a total of twenty-two configuration states

  3. Bilateral radial agenesis with absent thumbs, complex heart defect, short stature, and facial dysmorphism in a patient with pure distal microduplication of 5q35.2-5q35.3

    Directory of Open Access Journals (Sweden)

    Jamsheer Aleksander

    2013-01-01

    Full Text Available Abstract Background A partial duplication of the distal long arm of chromosome 5 (5q35-- > qter is known to be associated with a distinct phenotype referred to as Hunter-McAlpine syndrome. Clinical spectrum of this disorder mainly consists of mental retardation, microcephaly, short stature, skeletal anomalies, and craniofacial dysmorphism featuring flat facies, micrognathia, large, low-set dysplastic ears, hypertelorism, almond-shaped, down-slanted palpebral fissures, epicanthal folds, small nose, long philtrum, small mouth, and thin upper lip. Less frequent remarkable findings include craniosynostosis, heart defect, hypoplastic phalanges, preaxial polydactyly, hypospadias, cryptorchidism, and inguinal hernia. In most patients with a partial duplication of 5q the aberration occurred due to an inherited unbalanced translocation, therefore the phenotype was not reflective of pure trisomy 5q. Case presentation We report on a 9.5-year-old boy with some feature of Hunter-McAlpine syndrome including short stature, complex heart defect (dextrocardia, dextroversion, PFO, bilateral cryptorchidism, hypothyroidism, and craniofacial dysmorphism. Additionally, bilateral radial agenesis with complete absence of Ist digital rays, ulnar hypoplasia with bowing, choroidal and retinal coloboma, abnormal biliary vesicle were identified, which have never been noted in 5q trisomy patients. Karyotype analysis, sequencing and MLPA for TBX5 and SALL4 genes were unremarkable. Array comparative genomic hybridization detected a duplication on 5q35.2-5q35.3, resulting from a de novo chromosomal rearrangement. Our proband carried the smallest of all previously reported pure distal 5q trisomies encompassing terminal 5.4-5.6 Mb and presented with the most severe limb malformation attributed to the increased number of distal 5q copies. Conclusions We postulate that a terminal distal trisomy of 5q35.2-5q35.3, which maps 1.1 Mb telomeric to the MSX2 gene is causative for both

  4. Clinical phenotype and candidate genes for the 5q31.3 microdeletion syndrome.

    Science.gov (United States)

    Hosoki, Kana; Ohta, Tohru; Natsume, Jun; Imai, Sumiko; Okumura, Akihisa; Matsui, Takeshi; Harada, Naoki; Bacino, Carlos A; Scaglia, Fernando; Jones, Jeremy Y; Niikawa, Norio; Saitoh, Shinji

    2012-08-01

    Array-based technologies have led to the identification of many novel microdeletion and microduplication syndromes demonstrating multiple congenital anomalies and intellectual disability (MCA/ID). We have used chromosomal microarray analysis for the evaluation of patients with MCA/ID and/or neonatal hypotonia. Three overlapping de novo microdeletions at 5q31.3 with the shortest region of overlap (SRO) of 370 kb were detected in three unrelated patients. These patients showed similar clinical features including severe neonatal hypotonia, neonatal feeding difficulties, respiratory distress, characteristic facial features, and severe developmental delay. These features are consistent with the 5q31.3 microdeletion syndrome originally proposed by Shimojima et al., providing further evidence that this syndrome is clinically discernible. The 370 kb SRO encompasses only four RefSeq genes including neuregulin 2 (NRG2) and purine-rich element binding protein A (PURA). NRG2 is one of the members of the neuregulin family related to neuronal and glial cell growth and differentiation, thus making NRG2 a good candidate for the observed phenotype. Moreover, PURA is also a good candidate because Pura-deficient mice demonstrate postnatal neurological manifestations.

  5. Genetic and radiation hybrid mapping of the hyperekplexia region on chromosome 5q

    Energy Technology Data Exchange (ETDEWEB)

    Ryan, S.G.; O' Connell, P. (Univ. of Texas Health Science Center, San Antonio (United States)); Dixon, M.J. (Univ. of Manchester (United Kingdom)); Nigro, M.A. (Wayne State Univ., Detroit, MI (United States)); Kelts, K.A. (Black Hills Neurology, Rapid City, SD (United States)); Markand, O.N. (Indiana Univ., Indianopolis (United States)); Shiang, R.; Wasmuth, J.J. (Univ. of California, Irvine (United States)); Terry, J.C.

    1992-12-01

    Hyperekplexia, or startle disease (STHE), is an autosomal dominant neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to sudden, unexpected acoustic or tactile stimuli. STHE responds dramatically to the benzodiazepine drug clonazepam, which acts at gamma-aminobutyric acid type A (GABA-A) receptors. The STHE locus (STHE) was recently assigned to chromosome 5q, on the basis of tight linkage to the colony-stimulating factor 1-receptor (CSF1-R) locus in a single large family. The authors performed linkage analysis in the original and three additional STHE pedigrees with eight chromosome 5q microsatellite markers and placed several of the most closely linked markers on an existing radiation hybrid (RH) map of the region. The results provide strong evidence for genetic locus homogeneity and assign STHE to a 5.9-cM interval defined by CSF1-R and D5S379, which are separated by an RH map distance of 74 centirays (roughly 2.2-3.7 Mb). Two polymorphic markers (D5S119 and D5S209) lie within this region, but they could not be ordered with respect to STHE. RH mapping eliminated the candidate genes GABRA1 and GABRG2, which encode GABA-A receptor components, by showing that they are telomeric to the target region. 45 refs., 4 figs., 4 tabs.

  6. Variation in conserved non-coding sequences on chromosome 5q andsusceptibility to asthma and atopy

    Energy Technology Data Exchange (ETDEWEB)

    Donfack, Joseph; Schneider, Daniel H.; Tan, Zheng; Kurz,Thorsten; Dubchak, Inna; Frazer, Kelly A.; Ober, Carole

    2005-09-10

    Background: Evolutionarily conserved sequences likely havebiological function. Methods: To determine whether variation in conservedsequences in non-coding DNA contributes to risk for human disease, westudied six conserved non-coding elements in the Th2 cytokine cluster onhuman chromosome 5q31 in a large Hutterite pedigree and in samples ofoutbred European American and African American asthma cases and controls.Results: Among six conserved non-coding elements (>100 bp,>70percent identity; human-mouse comparison), we identified one singlenucleotide polymorphism (SNP) in each of two conserved elements and sixSNPs in the flanking regions of three conserved elements. We genotypedour samples for four of these SNPs and an additional three SNPs each inthe IL13 and IL4 genes. While there was only modest evidence forassociation with single SNPs in the Hutterite and European Americansamples (P<0.05), there were highly significant associations inEuropean Americans between asthma and haplotypes comprised of SNPs in theIL4 gene (P<0.001), including a SNP in a conserved non-codingelement. Furthermore, variation in the IL13 gene was strongly associatedwith total IgE (P = 0.00022) and allergic sensitization to mold allergens(P = 0.00076) in the Hutterites, and more modestly associated withsensitization to molds in the European Americans and African Americans (P<0.01). Conclusion: These results indicate that there is overalllittle variation in the conserved non-coding elements on 5q31, butvariation in IL4 and IL13, including possibly one SNP in a conservedelement, influence asthma and atopic phenotypes in diversepopulations.

  7. A YAC contig of approximately 3 Mb from human chromosome 5q31 [yields] q33

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xiang; Wang Jabs, E.; Hawkins, A.L.; Griffin, C.A. (John Hopkins School of Medicine, Baltimore, MD (United States)); Wise, C.A.; Lovett, M. (Univ. of Texas Southwestern Medical Center, Dallas, TX (United States)); Le Paslier, D. (CEPH, Paris (France)); Pittler, S.J. (Univ. of South Alabama College of Medicine, Mobile, AL (United States))

    1994-02-01

    The human chromosome 5q31-q33 region contains an interesting cluster of growth factor and receptor genes. In addition, several genetic disease loci have been localized within this region, but have not as yet been isolated as molecular clones. These include those loci involved in autosomal dominant limb-girdle muscular dystrophy, diastrophic dysplasia, Treacher Collins syndrome, and myeloid disorders associated with the 5q-syndrome. A yeast artificial chromosome (YAC) contig of this region would assist in the further localization and isolation of these genes. The authors have used YACs isolated from the Washington University and Centre d'Etude du Polymorphisme Humain YAC libraries, including YACs from the large insert (mega) YAC library to build a contig greater than 3 Mb in size. An STS content strategy coupled with limited walking from YAC ends was used to isolate 22 overlapping YACs with as much as sixfold coverage. A total of 20 STSs, derived from genes, anonymous sequences, and vector Alu-PCR or inverse PCR products, were used to compile this contig. The order of loci, centromere-GRL-D5S207-D5S70-D5S545-D5S546-D5S547-D5S68-D5S548-D5S210-D5S549-D5S686- ADRB2-D5S559-CSF1R-D5S551-RPS14-D5S519-SPARC-telomere, was derived from the overlapping clones. This contig and clones derived from it will be useful substrates in selecting candidate cDNAs for the disease loci in this interval. 45 refs., 1 fig., 2 tabs.

  8. New superhindered polydentate polyphosphine ligands P(CH2CH2P(t)Bu2)3, PhP(CH2CH2P(t)Bu2)2, P(CH2CH2CH2P(t)Bu2)3, and their ruthenium(II) chloride complexes.

    Science.gov (United States)

    Gilbert-Wilson, Ryan; Field, Leslie D; Bhadbhade, Mohan M

    2012-03-01

    The synthesis and characterization of the extremely hindered phosphine ligands, P(CH(2)CH(2)P(t)Bu(2))(3) (P(2)P(3)(tBu), 1), PhP(CH(2)CH(2)P(t)Bu(2))(2) (PhP(2)P(2)(tBu), 2), and P(CH(2)CH(2)CH(2)P(t)Bu(2))(3) (P(3)P(3)(tBu), 3) are reported, along with the synthesis and characterization of ruthenium chloro complexes RuCl(2)(P(2)P(3)(tBu)) (4), RuCl(2)(PhP(2)P(2)(tBu)) (5), and RuCl(2)(P(3)P(3)(tBu)) (6). The bulky P(2)P(3)(tBu) (1) and P(3)P(3)(tBu) (3) ligands are the most sterically encumbered PP(3)-type ligands so far synthesized, and in all cases, only three phosphorus donors are able to bind to the metal center. Complexes RuCl(2)(PhP(2)P(2)(tBu)) (5) and RuCl(2)(P(3)P(3)(tBu)) (6) were characterized by crystallography. Low temperature solution and solid state (31)P{(1)H} NMR were used to demonstrate that the structure of RuCl(2)(P(2)P(3)(tBu)) (4) is probably analogous to that of RuCl(2)(PhP(2)P(2)(tBu)) (5) which had been structurally characterized.

  9. Targeted re-sequencing analysis of 25 genes commonly mutated in myeloid disorders in del(5q) myelodysplastic syndromes

    Science.gov (United States)

    Fernandez-Mercado, Marta; Burns, Adam; Pellagatti, Andrea; Giagounidis, Aristoteles; Germing, Ulrich; Agirre, Xabier; Prosper, Felipe; Aul, Carlo; Killick, Sally; Wainscoat, James S.; Schuh, Anna; Boultwood, Jacqueline

    2013-01-01

    Interstitial deletion of chromosome 5q is the most common chromosomal abnormality in myelodysplastic syndromes. The catalogue of genes involved in the molecular pathogenesis of myelodysplastic syndromes is rapidly expanding and next-generation sequencing technology allows detection of these mutations at great depth. Here we describe the design, validation and application of a targeted next-generation sequencing approach to simultaneously screen 25 genes mutated in myeloid malignancies. We used this method alongside single nucleotide polymorphism-array technology to characterize the mutational and cytogenetic profile of 43 cases of early or advanced del(5q) myelodysplastic syndromes. A total of 29 mutations were detected in our cohort. Overall, 45% of early and 66.7% of advanced cases had at least one mutation. Genes with the highest mutation frequency among advanced cases were TP53 and ASXL1 (25% of patients each). These showed a lower mutation frequency in cases of 5q- syndrome (4.5% and 13.6%, respectively), suggesting a role in disease progression in del(5q) myelodysplastic syndromes. Fifty-two percent of mutations identified were in genes involved in epigenetic regulation (ASXL1, TET2, DNMT3A and JAK2). Six mutations had allele frequencies <20%, likely below the detection limit of traditional sequencing methods. Genomic array data showed that cases of advanced del(5q) myelodysplastic syndrome had a complex background of cytogenetic aberrations, often encompassing genes involved in myeloid disorders. Our study is the first to investigate the molecular pathogenesis of early and advanced del(5q) myelodysplastic syndromes using next-generation sequencing technology on a large panel of genes frequently mutated in myeloid malignancies, further illuminating the molecular landscape of del(5q) myelodysplastic syndromes. PMID:23831921

  10. Energy and Auger Widths of Triply Excited 3p3p3p 2po State of Lithium

    Institute of Scientific and Technical Information of China (English)

    苟秉聪; 俞开智

    2003-01-01

    The high-lying triply excited 3p3p3p 2po state of the double hollow lithium atom is studied by using the saddlepoint complex-rotation method. The energy and Auger widths of this resonance are calculated. The relativistic corrections and mass polarization are included. The total Auger width is obtained by coupling the important open channels and summing over the other channels. The oscillator strength is also calculated. The results are compared with other theoretical and experimental data in the literature.

  11. A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals

    Science.gov (United States)

    Sobota, Rafal S.; Stein, Catherine M.; Kodaman, Nuri; Scheinfeldt, Laura B.; Maro, Isaac; Wieland-Alter, Wendy; Igo, Robert P.; Magohe, Albert; Malone, LaShaunda L.; Chervenak, Keith; Hall, Noemi B.; Modongo, Chawangwa; Zetola, Nicola; Matee, Mecky; Joloba, Moses; Froment, Alain; Nyambo, Thomas B.; Moore, Jason H.; Scott, William K.; Lahey, Timothy; Boom, W. Henry; von Reyn, C. Fordham; Tishkoff, Sarah A.; Sirugo, Giorgio; Williams, Scott M.

    2016-01-01

    Immunosuppression resulting from HIV infection increases the risk of progression to active tuberculosis (TB) both in individuals newly exposed to Mycobacterium tuberculosis (MTB) and in those with latent infections. We hypothesized that HIV-positive individuals who do not develop TB, despite living in areas where it is hyperendemic, provide a model of natural resistance. We performed a genome-wide association study of TB resistance by using 581 HIV-positive Ugandans and Tanzanians enrolled in prospective cohort studies of TB; 267 of these individuals developed active TB, and 314 did not. A common variant, rs4921437 at 5q33.3, was significantly associated with TB (odds ratio = 0.37, p = 2.11 × 10−8). This variant lies within a genomic region that includes IL12B and is embedded in an H3K27Ac histone mark. The locus also displays consistent patterns of linkage disequilibrium across African populations and has signals of strong selection in populations from equatorial Africa. Along with prior studies demonstrating that therapy with IL-12 (the cytokine encoded in part by IL12B, associated with longer survival following MTB infection in mice deficient in CD4 T cells), our results suggest that this pathway might be an excellent target for the development of new modalities for treating TB, especially for HIV-positive individuals. Our results also indicate that studying extreme disease resistance in the face of extensive exposure can increase the power to detect associations in complex infectious disease. PMID:26942285

  12. The association between DNA copy number aberrations at chromosome 5q22 and gastric cancer.

    Directory of Open Access Journals (Sweden)

    Pei-Chien Tsai

    Full Text Available BACKGROUND: Gastric cancer is common cancer. Discovering novel genetic biomarkers might help to identify high-risk individuals. Copy number variation (CNV has recently been shown to influence risk for several cancers. The aim of the present study was sought to test the association between copy number at a variant region and GC. METHODS: A total of 110 gastric cancer patients and 325 healthy volunteers were enrolled in this study. We searched for a CNV and found a CNV (Variation 7468 containing part of the APC gene, the SRP19 gene and the REEP5 gene. We chose four probes targeting at APC-intron8, APC-exon9, SRP19 and REEP5 to interrogate this CNV. Specific Taqman probes labeled by different reporter fluorophores were used in a real-time PCR platform to obtain copy number. Both the original non-integer data and transformed integer data on copy number were used for analyses. RESULTS: Gastric caner patients had a lower non-integer copy number than controls for the APC-exon9 probe (Adjusted p = 0.026 and SRP19 probe (Adjusted p = 0.002. The analysis of integer copy number yielded a similar pattern although less significant (Adjusted p = 0.07 for APC-exon9 probe and Adjusted p = 0.02 for SRP19 probe. CONCLUSIONS: Losses of a CNV at 5q22, especially in the DNA region surrounding APC-exon 9, may be associated with a higher risk of gastric cancer.

  13. p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q)

    NARCIS (Netherlands)

    Saft, L.; Karimi, M.; Ghaderi, M.; Matolcsy, A.; Mufti, G.J.; Kulasekararaj, A.; Gohring, G.; Giagounidis, A.; Selleslag, D.; Muus, P.; Sanz, G.; Mittelman, M.; Bowen, D.; Porwit, A.; Fu, T.; Backstrom, J.; Fenaux, P.; MacBeth, K.J.; Hellstrom-Lindberg, E.

    2014-01-01

    Del(5q) myelodysplastic syndromes defined by the International Prognostic Scoring System as low- or intermediate-1-risk (lower-risk) are considered to have an indolent course; however, recent data have identified a subgroup of these patients with more aggressive disease and poorer outcomes. Using de

  14. Multiphysics Applications of ACE3P

    Energy Technology Data Exchange (ETDEWEB)

    K.H. Lee, C. Ko, Z. Li, C.-K. Ng, L. Xiao, G. Cheng, H. Wang

    2012-07-01

    The TEM3P module of ACE3P, a parallel finite-element electromagnetic code suite from SLAC, focuses on the multiphysics simulation capabilities, including thermal and mechanical analysis for accelerator applications. In this pa- per, thermal analysis of coupler feedthroughs to supercon- ducting rf (SRF) cavities will be presented. For the realistic simulation, internal boundary condition is implemented to capture RF heating effects on the surface shared by a di- electric and a conductor. The multiphysics simulation with TEM3P matched the measurement within 0.4%.

  15. Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide

    Directory of Open Access Journals (Sweden)

    Sugimoto Yuka

    2012-03-01

    Full Text Available Abstract Background While lenalidomide (LEN shows high efficacy in myelodysplastic syndromes (MDS with del[5q], responses can be also seen in patients presenting without del[5q]. We hypothesized that improved detection of chromosomal abnormalities with new karyotyping tools may better predict response to LEN. Design and methods We have studied clinical, molecular and cytogenetic features of 42 patients with MDS, myeloproliferative neoplasms (MPN, MDS/MPN overlap syndromes and secondary acute myeloid leukemia (sAML without del[5q] by metaphase cytogenetics (MC who underwent therapy with LEN. Results Fluorescence in situ hybridization (FISH or single nucleotide polymorphism array (SNP-A-based karyotyping marginally increased the diagnostic yield over MC, detecting 2/42 (4.8% additional cases with del[5q], one of whom were responded to LEN. Responses were more often observed in patients with a normal karyotype by MC (60% vs abnormal MC; 17%, p = .08 and those with gain of chromosome 8 material by either of all 3 karyotyping methods (83% vs all other chromosomal abnormalities; 44% p = .11. However, 5 out of those 6 patients received combined LEN/AZA therapy and it may also suggest those with gain of chromosome 8 material respond well to AZA. The addition of FISH or SNP-A did not improve the predictive value of normal cytogenetics by MC. Mutational analysis of TET2, UTX, CBL, EZH2, ASXL1, TP53, RAS, IDH1/2, and DNMT-3A was performed on 21 of 41 patients, and revealed 13 mutations in 11 patients, but did not show any molecular markers of responsiveness to LEN. Conclusions Normal karyotype and gain of chromosome 8 material was predictive of response to LEN in non-del[5q] patients with myeloid malignancies.

  16. Collision-induced intramultiplet mixing for the Ne**[(2p)5(3p)] + He or Ne system

    International Nuclear Information System (INIS)

    For the Ne**-He case, experimental data are confronted with quantum mechanical calculations. Quantum mechanical coupled-channel calculations using model potentials as input are presented, followed by a semiclassical approach which provides more physical insight. Experimental results are presented for the Ne**-Ne system with a discussion of the general principles involved in symmetrization. 184 refs.; 93 figs.; 19 tabs

  17. Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population.

    Science.gov (United States)

    Loh, E W; Tang, N L S; Lee, D T S; Liu, S I; Stadlin, Alfreda

    2007-06-01

    GABAA receptor subunit genes clustered on 5q33 play a role in the development of alcoholism and methamphetamine use disorder without psychosis. The present study explored the possible contribution of the same subunit genes to the development of heroin dependence. Single nucleotide polymorphisms (SNPs) of the GABAA receptor subunits GABRB2, GABRA6, GABRA1, and GABRG2 were examined in 178 male Han Chinese heroin-dependent and 170 male control subjects. A significant difference in allele frequency for the SNP rs211014 in the GABAAgamma2 receptor subunit gene between cases and controls was identified (P = 0.015). A possible mechanism for the involvement of the GABA receptor subunit genes on 5q33 in the development of heroin dependence is discussed. PMID:17440936

  18. Thermoelastic properties of Zn3P2

    DEFF Research Database (Denmark)

    Gerward, Leif; Olsen, J. Staun; Waśkowska, A.

    2011-01-01

    The bulk modulus and thermal expansion of Zn3P2 has been investigated at pressures up to 21GPa and temperatures down to 100K. The experimental zero-pressure bulk modulus is 80.7 ± 1.8GPa, in accordance with the bulk modulus scaling and lattice properties of the related compound Cd3P2. A tetragonal...... to orthorhombic phase transformation occurs above 11GPa with a relative volume change of-7.1%. Values for the thermal expansion coefficient are reported at 293, 200 and 100K....

  19. Measurements of oscillator strengths of the 2p{sup 5}({sup 2}P{sub 1/2})nd J = 2, 3 autoionizing resonances in neon

    Energy Technology Data Exchange (ETDEWEB)

    Mahmood, Shaukat; Amin, Nasir; Sami-ul-Haq; Shaikh, Nek M; Hussain, Shahid; Baig, M A [Atomic and Molecular Physics Laboratory, Department of Physics, Quaid-i-Azam University, Islamabad 45320 (Pakistan)

    2006-05-14

    Oscillator strengths of the 2p{sup 5}({sup 2}P{sub 1/2})nd J = 2, 3 autoionizing resonances in neon have been determined using a dc discharge plasma in conjunction with an Nd:YAG pumped dye laser system. The excited states are approached using two-step laser excitation via 2p{sup 5}3p'[1/2]{sub 1}, 2p{sup 5}3p'[3/2]{sub 1} and 2p{sup 5}3p'[3/2]{sub 2} intermediate states which are accessed from the 2p{sup 5}3s [1/2]{sub 2} metastable state, populated by the discharge in the hollow cathode lamp. The f-values have been determined for the nd'[3/2]{sub 2}, nd'[5/2]{sub 2} and nd'[5/2]{sub 3} series following the {delta}K = {delta}J = +{delta}l selection rule. Employing the saturation technique the photoionization cross section at the 2p{sup 5} {sup 2}P{sub 1/2} ionization threshold is determined as 5.5(6) Mb and consequently the f-values of the nd' J = 2, 3 autoionizing resonances have been extracted.

  20. A novel 5q11.2 microdeletion in a child with mild developmental delay and dysmorphic features.

    Science.gov (United States)

    Fontana, Paolo; Tortora, Cristina; Petillo, Roberta; Falco, Mariateresa; Miniero, Martina; De Brasi, Davide; Pisanti, Maria Antonietta

    2016-09-01

    5q11.2 Deletion is a very rare genomic disorder, and its clinical phenotype has not yet been characterized. This report describes a patient with an 8.6 Mb deletion, showing hypotonia, mild developmental delay, short stature, and distinctive dysmorphic features (frontal bossing, square face, deep-set eyes, prominent columella, long philtrum, thin lips). © 2016 Wiley Periodicals, Inc.

  1. A syndromic form of Pierre Robin sequence is caused by 5q23 deletions encompassing FBN2 and PHAX.

    Science.gov (United States)

    Ansari, Morad; Rainger, Jacqueline K; Murray, Jennie E; Hanson, Isabel; Firth, Helen V; Mehendale, Felicity; Amiel, Jeanne; Gordon, Christopher T; Percesepe, Antonio; Mazzanti, Laura; Fryer, Alan; Ferrari, Paola; Devriendt, Koenraad; Temple, I Karen; FitzPatrick, David R

    2014-10-01

    Pierre Robin sequence (PRS) is an aetiologically distinct subgroup of cleft palate. We aimed to define the critical genomic interval from five different 5q22-5q31 deletions associated with PRS or PRS-associated features and assess each gene within the region as a candidate for the PRS component of the phenotype. Clinical array-based comparative genome hybridisation (aCGH) data were used to define a 2.08 Mb minimum region of overlap among four de novo deletions and one mother-son inherited deletion associated with at least one component of PRS. Commonly associated anomalies were talipes equinovarus (TEV), finger contractures and crumpled ear helices. Expression analysis of the orthologous genes within the PRS critical region in embryonic mice showed that the strongest candidate genes were FBN2 and PHAX. Targeted aCGH of the critical region and sequencing of these genes in a cohort of 25 PRS patients revealed no plausible disease-causing mutations. In conclusion, deletion of ∼2 Mb on 5q23 region causes a clinically recognisable subtype of PRS. Haploinsufficiency for FBN2 accounts for the digital and auricular features. A possible critical region for TEV is distinct and telomeric to the PRS region. The molecular basis of PRS in these cases remains undetermined but haploinsufficiency for PHAX is a plausible mechanism.

  2. Plasma diagnostic potential of 2p4f in N$^+$ -- accurate wavelengths and oscillator strengths

    OpenAIRE

    Shen, Xiaozhi; Li, Jiguang; Jönsson, Per; Wang, Jianguo

    2015-01-01

    Radiative emission lines from nitrogen and its ions are often observed in nebulae spectra, where the N$^{2+}$ abundance can be inferred from lines of the 2p4f configuration. In addition, intensity ratios between lines of the 2p3p -- 2p3s and 2p4f -- 2p3d transition arrays can serve as temperature diagnostics. To aid abundance determinations and plasma diagnostics, wavelengths and oscillator strengths were calculated with high-precision for electric-dipole (E1) transitions from levels in the 2...

  3. Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1

    NARCIS (Netherlands)

    D.M. Glubb (Dylan); M. Maranian (Melanie); K. Michailidou (Kyriaki); K.A. Pooley (Karen); K.B. Meyer (Kerstin); S. Kar (Siddhartha); A.F.C. Carlebur; M. O'Reilly (Marian); J.A. Betts (Joshua); K.M. Hillman (Kristine); S. Kaufmann (Susanne); J. Beesley (Jonathan); S. Canisius (Sander); J.L. Hopper (John); M.C. Southey (Melissa); H. Tsimiklis (Helen); C. Apicella (Carmel); M.K. Schmidt (Marjanka); A. Broeks (Annegien); F.B.L. Hogervorst (Frans); C.E. van der Schoot (Ellen); K.R. Muir (K.); A. Lophatananon (Artitaya); S. Stewart-Brown (Sarah); P. Siriwanarangsan (Pornthep); P.A. Fasching (Peter); M. Ruebner (Matthias); A.B. Ekici (Arif); M.W. Beckmann (Matthias W.); J. Peto (Julian); I. dos Santos Silva (Isabel); O. Fletcher (Olivia); N. Johnson (Nichola); P.D.P. Pharoah (Paul D.P.); M.K. Bolla (Manjeet); Q. Wang (Qing); J. Dennis (Joe); E.J. Sawyer (Elinor); I.P. Tomlinson (Ian); M. Kerin (Michael); N. Miller (Nicola); B. Burwinkel (Barbara); F. Marme (Federick); R. Yang (Rongxi); H. Surowy (Harald); P. Guénel (Pascal); T. Truong (Thérèse); F. Menegaux (Florence); M. Sanchez (Marie); S.E. Bojesen (Stig); B.G. Nordestgaard (Børge); S.F. Nielsen (Sune); H. Flyger (Henrik); A. González-Neira (Anna); J. Benítez (Javier); M.P. Zamora (Pilar); J.I. Arias Pérez (José Ignacio); H. Anton-Culver (Hoda); S.L. Neuhausen (Susan); H. Brenner (Hermann); A.K. Dieffenbach (Aida Karina); V. Arndt (Volker); C. Stegmaier (Christa); A. Meindl (Alfons); R.K. Schmutzler (Rita); H. Brauch (Hiltrud); Y.-D. Ko (Yon-Dschun); T. Brüning (Thomas); H. Nevanlinna (Heli); T.A. Muranen (Taru); K. Aittomäki (Kristiina); C. Blomqvist (Carl); K. Matsuo (Keitaro); H. Ito (Hidemi); H. Iwata (Hisato); H. Tanaka (Hideo); T. Dörk (Thilo); N.V. Bogdanova (Natalia); S. Helbig (Sonja); A. Lindblom (Annika); S. Margolin (Sara); A. Mannermaa (Arto); V. Kataja (Vesa); V-M. Kosma (Veli-Matti); J.M. Hartikainen (J.); A.H. Wu (Anna H.); C.-C. Tseng (Chiu-Chen); D. Van Den Berg (David); D.O. Stram (Daniel O.); D. Lambrechts (Diether); H. Zhao (Hui); C. Weltens (Caroline); E. van Limbergen (Erik); J. Chang-Claude (Jenny); D. Flesch-Janys (Dieter); A. Rudolph (Anja); P. Seibold (Petra); P. Radice (Paolo); P. Peterlongo (Paolo); M. Barile (Monica); F. Capra (Fabio); F.J. Couch (Fergus); J.E. Olson (Janet); B. Hallberg (Boubou); C. Vachon (Celine); G.G. Giles (Graham); R.L. Milne (Roger); C.A. McLean (Catriona Ann); C.A. Haiman (Christopher); B.E. Henderson (Brian); F.R. Schumacher (Fredrick); L. Le Marchand (Loic); J. Simard (Jacques); M.S. Goldberg (Mark); F. Labrèche (France); M. Dumont (Martine); S.-H. Teo; C.H. Yip (Cheng Har); M.-H. See (Mee-Hoong); B.K. Cornes (Belinda); C.-Y. Cheng (Ching-Yu); M.K. Ikram (Kamran); V. Kristensen (Vessela); W. Zheng (Wei); S.L. Halverson (Sandra L.); M. Shrubsole (Martha); J. Long (Jirong); R. Winqvist (Robert); K. Pykäs (Katri); A. Jukkola-Vuorinen (Arja); S. Kauppila (Saila); I.L. Andrulis (Irene); J.A. Knight (Julia); G. Glendon (Gord); S. Tchatchou (Sandrine); P. Devilee (Peter); R.A.E.M. Tollenaar (Rob); C.M. Seynaeve (Caroline); C.J. van Asperen (Christi); M. García-Closas (Montserrat); J.D. Figueroa (Jonine); S.J. Chanock (Stephen); J. Lissowska (Jolanta); K. Czene (Kamila); D. Klevebring (Daniel); H. Darabi (Hatef); M. Eriksson (Mikael); M.J. Hooning (Maartje); A. Hollestelle (Antoinette); J.W.M. Martens (John W. M.); J.M. Collee (Margriet); P. Hall (Per); J. Li (Jingmei); K. Humphreys (Keith); X.-O. Shu (Xiao-Ou); W. Lu (Wei); Y.-T. Gao (Yu-Tang); H. Cai (Hui); A. Cox (Angela); S.S. Cross (Simon); M.W.R. Reed (Malcolm); W.J. Blot (William); L.B. Signorello (Lisa B.); Q. Cai (Qiuyin); M. Shah (Mitul); M. Ghoussaini (Maya); D. Kang (Daehee); J.-Y. Choi (J.); S.K. Park (Sue); D-Y. Noh (Dong-Young); M. Hartman (Mikael); X. Miao; W.-Y. Lim (Wei-Yen); A. Tang (Anthony); U. Hamann (Ute); D. Torres (Diana); A. Jakubowska (Anna); J. Lubinski (Jan); K. Jaworska (Katarzyna); K. Durda (Katarzyna); S. Sangrajrang (Suleeporn); V. Gaborieau (Valerie); P. Brennan (Paul); J.D. McKay (James); C. Olswold (Curtis); S. Slager (Susan); A.E. Toland (Amanda); D. Yannoukakos (Drakoulis); C-Y. Shen (Chen-Yang); P.-E. Wu (Pei-Ei); J-C. Yu (Jyh-Cherng); M.-F. Hou (Ming-Feng); A.J. Swerdlow (Anthony ); A. Ashworth (Alan); N. Orr (Nick); M. Jones (Michael); G. Pita (G.); M.R. Alonso (M Rosario); N. Álvarez (Nuria); D. Herrero (Daniel); D.C. Tessier (Daniel C.); D. Vincent (Daniel); F. Bacot (Francois); C. Luccarini (Craig); C. Baynes (Caroline); S. Ahmed (Shahana); S. Healey (Sue); M. Brown (Melissa); B.A.J. Ponder (Bruce A.J.); G. Chenevix-Trench (Georgia); D. Thompson (Deborah); S.L. Edwards (Stacey); D.F. Easton (Douglas); A.M. Dunning (Alison); J.D. French (Juliet)

    2015-01-01

    textabstractGenome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt to identify the biologically relevant variants, we analyzed 909 genetic variants across 5q11.2 in 103,991 breast cancer indiv

  4. Definition of 5q11.2 Microdeletion Syndrome Reveals Overlap with CHARGE Syndrome and 22q11 Deletion Syndrome Phenotypes

    NARCIS (Netherlands)

    Blok, Charlotte Snijders; Corsten-Janssen, Nicole; FitzPatrick, David R.; Romano, Corrado; Fichera, Marco; Vitello, Girolamo Aurelio; Willemsen, Marjolein H.; Schoots, Jeroen; Pfundt, Rolph; van Ravenswaaij-Arts, Conny M. A.; Hoefsloot, Lies; Kleefstra, Tjitske

    2014-01-01

    Microdeletions of the 5q11.2 region are rare; in literature only two patients with a deletion in this region have been reported so far. In this study, we describe four additional patients and further define this new 5q11.2 microdeletion syndrome. A comparison of the features observed in all six pati

  5. UNITS IN $F_2D_{2p}$

    OpenAIRE

    Kaur, Kuldeep; Khan, Manju

    2012-01-01

    Let $p$ be an odd prime, $D_{2p}$ be the dihedral group of order 2p, and $F_{2}$ be the finite field with two elements. If * denotes the canonical involution of the group algebra $F_2D_{2p}$, then bicyclic units are unitary units. In this note, we investigate the structure of the group $\\mathcal{B}(F_2D_{2p})$, generated by the bicyclic units of the group algebra $F_2D_{2p}$. Further, we obtain the structure of the unit group $\\mathcal{U}(F_2D_{2p})$ and the unitary subgroup $\\mathcal{U}_*(F_...

  6. Trisomy 2p: Analysis of unusual phenotypic findings

    Energy Technology Data Exchange (ETDEWEB)

    Lurie, I.W.; Ilyina, H.G.; Gurevich, D.B. [Belorussian Research Institute of Hereditary Disease, Minsk (Russian Federation)] [and others

    1995-01-16

    We present three probands with partial trisomies 2p21-23 due to ins(4;2)(q21;p21p23) pat, 2p23-pter due to t(2;4)(p23;q35)mat, and 2p21-pter due to t(2;11)(p21;q23.3)mat. More than 50 cases of partial trisomy 2p have been reviewed and some abnormalities, unusual for most other types of structural autosomal imbalance, have been found in patients with inherited forms of 2p trisomy and in their non-karyotyped sibs. Neural tube defects (anencephaly, occipital encephalocele, and spina bifida) were found in five probands and 4/6 affected non-karyotyped sibs. The only triplicated segment common to all was 2p24. Different forms of {open_quotes}broncho-pulmonary a/hypoplasia{close_quotes} (including two cases of lung agenesis) were described in four patients (overlapping triplicated segment was 2p21-p25). Three patients (with overlapping triplicated segment 2p23-p25) had diaphragmatic hernia. Abnormal rotation of the heart or L-transposition of large vessels (with or without visceral heterotaxia) was found in two infants (overlapping triplicated segment 2p23-p24). In two patients with common triplicated segment 2p22.3-p25, neuroblastoma has been described. The occurrence of all these defects may be explained either by the action of the same gene(s) mapped to 2p24 or by action of some independent factors located in different segments of the short arm. Although the latter hypothesis is much less probable, it can not be rejected at the present time. We propose the existence of a genetic system controlling surveillance of an abnormal embryo to explain the phenotypic differences between patients with the same imbalance within a family. In some {open_quotes}restrictive{close_quotes} combinations the abnormal embryos will die, although in {open_quotes}permissive{close_quotes} combinations they can survive. 47 refs., 2 figs., 3 tabs.

  7. p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q)

    Science.gov (United States)

    Saft, Leonie; Karimi, Mohsen; Ghaderi, Mehran; Matolcsy, András; Mufti, Ghulam J.; Kulasekararaj, Austin; Göhring, Gudrun; Giagounidis, Aristoteles; Selleslag, Dominik; Muus, Petra; Sanz, Guillermo; Mittelman, Moshe; Bowen, David; Porwit, Anna; Fu, Tommy; Backstrom, Jay; Fenaux, Pierre; MacBeth, Kyle J.; Hellström-Lindberg, Eva

    2014-01-01

    Del(5q) myelodysplastic syndromes defined by the International Prognostic Scoring System as low- or intermediate-1-risk (lower-risk) are considered to have an indolent course; however, recent data have identified a subgroup of these patients with more aggressive disease and poorer outcomes. Using deep sequencing technology, we previously demonstrated that 18% of patients with lower-risk del(5q) myelodysplastic syndromes carry TP53 mutated subclones rendering them at higher risk of progression. In this study, bone marrow biopsies from 85 patients treated with lenalidomide in the MDS-004 clinical trial were retrospectively assessed for p53 expression by immunohistochemistry in association with outcome. Strong p53 expression in ≥1% of bone marrow progenitor cells, observed in 35% (30 of 85) of patients, was significantly associated with higher acute myeloid leukemia risk (P=0.0006), shorter overall survival (P=0.0175), and a lower cytogenetic response rate (P=0.009), but not with achievement or duration of 26-week transfusion independence response. In a multivariate analysis, p53-positive immunohistochemistry was the strongest independent predictor of transformation to acute myeloid leukemia (P=0.0035). Pyrosequencing analysis of laser-microdissected cells with strong p53 expression confirmed the TP53 mutation, whereas cells with moderate expression predominantly had wild-type p53. This study validates p53 immunohistochemistry as a strong and clinically useful predictive tool in patients with lower-risk del(5q) myelodysplastic syndromes. This study was based on data from the MDS 004 trial (clinicaltrials.gov identifier: NCT00179621). PMID:24682512

  8. Towards P2P XML Database Technology

    NARCIS (Netherlands)

    Zhang, Y.

    2007-01-01

    To ease the development of data-intensive P2P applications, we envision a P2P XML Database Management System (P2P XDBMS) that acts as a database middle-ware, providing a uniform database abstraction on top of a dynamic set of distributed data sources. In this PhD work, we research which features suc

  9. Cytogenetic follow-up by karyotyping and fluorescence in situ hybridization: implications for monitoring patients with myelodysplastic syndrome and deletion 5q treated with lenalidomide

    Science.gov (United States)

    Göhring, Gudrun; Giagounidis, Aristoteles; Büsche, Guntram; Hofmann, Winfried; Kreipe, Hans Heinrich; Fenaux, Pierre; Hellström-Lindberg, Eva; Schlegelberger, Brigitte

    2011-01-01

    In patients with low and intermediate risk myelodysplastic syndrome and deletion 5q (del(5q)) treated with lenalidomide, monitoring of cytogenetic response is mandatory, since patients without cytogenetic response have a significantly increased risk of progression. Therefore, we have reviewed cytogenetic data of 302 patients. Patients were analyzed by karyotyping and fluorescence in situ hybridization. In 85 patients, del(5q) was only detected by karyotyping. In 8 patients undergoing karyotypic evolution, the del(5q) and additional chromosomal aberrations were only detected by karyotyping. In 3 patients, del(5q) was only detected by fluorescence in situ hybridization, but not by karyotyping due to a low number of metaphases. Karyotyping was significantly more sensitive than fluorescence in situ hybridization in detecting the del(5q) clone. In conclusion, to optimize therapy control of myelodysplastic syndrome patients with del(5q) treated with lenalidomide and to identify cytogenetic non-response or progression as early as possible, fluorescence in situ hybridization alone is inadequate for evaluation. Karyotyping must be performed to optimally evaluate response. (clinicaltrials.gov identifier: NCT01099267 and NCT00179621) PMID:21109690

  10. TP53 and MDM2 single nucleotide polymorphisms influence survival in non-del(5q) myelodysplastic syndromes.

    Science.gov (United States)

    McGraw, Kathy L; Cluzeau, Thomas; Sallman, David A; Basiorka, Ashley A; Irvine, Brittany A; Zhang, Ling; Epling-Burnette, P K; Rollison, Dana E; Mallo, Mar; Sokol, Lubomir; Solé, Francesc; Maciejewski, Jaroslaw; List, Alan F

    2015-10-27

    P53 is a key regulator of many cellular processes and is negatively regulated by the human homolog of murine double minute-2 (MDM2) E3 ubiquitin ligase. Single nucleotide polymorphisms (SNPs) of either gene alone, and in combination, are linked to cancer susceptibility, disease progression, and therapy response. We analyzed the interaction of TP53 R72P and MDM2 SNP309 SNPs in relationship to outcome in patients with myelodysplastic syndromes (MDS). Sanger sequencing was performed on DNA isolated from 208 MDS cases. Utilizing a novel functional SNP scoring system ranging from +2 to -2 based on predicted p53 activity, we found statistically significant differences in overall survival (OS) (p = 0.02) and progression-free survival (PFS) (p = 0.02) in non-del(5q) MDS patients with low functional scores. In univariate analysis, only IPSS and the functional SNP score predicted OS and PFS in non-del(5q) patients. In multivariate analysis, the functional SNP score was independent of IPSS for OS and PFS. These data underscore the importance of TP53 R72P and MDM2 SNP309 SNPs in MDS, and provide a novel scoring system independent of IPSS that is predictive for disease outcome. PMID:26416416

  11. Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy

    Directory of Open Access Journals (Sweden)

    Dubchak Inna

    2005-12-01

    Full Text Available Abstract Background Evolutionarily conserved sequences likely have biological function. Methods To determine whether variation in conserved sequences in non-coding DNA contributes to risk for human disease, we studied six conserved non-coding elements in the Th2 cytokine cluster on human chromosome 5q31 in a large Hutterite pedigree and in samples of outbred European American and African American asthma cases and controls. Results Among six conserved non-coding elements (>100 bp, >70% identity; human-mouse comparison, we identified one single nucleotide polymorphism (SNP in each of two conserved elements and six SNPs in the flanking regions of three conserved elements. We genotyped our samples for four of these SNPs and an additional three SNPs each in the IL13 and IL4 genes. While there was only modest evidence for association with single SNPs in the Hutterite and European American samples (P IL4 gene (P IL13 gene was strongly associated with total IgE (P = 0.00022 and allergic sensitization to mold allergens (P = 0.00076 in the Hutterites, and more modestly associated with sensitization to molds in the European Americans and African Americans (P Conclusion These results indicate that there is overall little variation in the conserved non-coding elements on 5q31, but variation in IL4 and IL13, including possibly one SNP in a conserved element, influence asthma and atopic phenotypes in diverse populations.

  12. $^3P_2$ Superfluids Are Topological

    CERN Document Server

    Mizushima, Takeshi

    2016-01-01

    We clarify the topology of the $^3P_2$ superfluidity which is expected to be realized in the cores of neutron stars and cubic odd-parity superconductors. The phase diagram includes the unitary uniaxial/biaxial nematic phases and nonunitary ferromagnetic and cyclic phases. We here show that the low-energy structures of all the phases are governed by different types of topologically protected gapless fermionic excitations: Surface Majorana fermions in nematic phases, single itinerant Majorana fermion in the ferromagnetic phase, and a quartet of itinerant Majorana fermions in the cyclic phase. Using the superfluid Fermi liquid theory, we also demonstrate that dihedral-two and -four biaxial nematic phases are thermodynamically favored in the weak coupling limit under a magnetic field. The mass acquisition of surface Majorana fermions in nematic phases is subject to symmetry.

  13. Lenalidomide as a disease-modifying agent in patients with del(5q) myelodysplastic syndromes: linking mechanism of action to clinical outcomes

    OpenAIRE

    Giagounidis, Aristoteles; Mufti, Ghulam J.; Fenaux, Pierre; Germing, Ulrich; List, Alan; MacBeth, Kyle J.

    2013-01-01

    Deletion of the long arm of chromosome 5, del(5q), is the most prevalent cytogenetic abnormality in patients with myelodysplastic syndromes (MDS). In isolation, it is traditionally associated with favorable prognosis compared with other subtypes of MDS. However, owing to the inherent heterogeneity of the disease, prognosis for patients with del(5q) MDS is highly variable depending on the presence of factors such as additional chromosomal abnormalities, >5 % blasts in the bone marrow (BM), or ...

  14. Propiedad Intelectual y Redes P2P

    OpenAIRE

    ALCAINE SÁNCHEZ, JUAN FRANCISCO

    2015-01-01

    La meta de este documento no es otra que la de presentar al lector información acerca de la legislación sobre propiedad intelectual y distintos protocolos y software P2P. Primero se mostrará información sobre las principales leyes españolas en materia de propiedad intelectual. Posteriormente se presentará información acerca de los principales protocolos P2P sus clientes a lo largo de la historia de las redes P2P. Por último, se mostrarán las alternativas de pago a la descarga no lega...

  15. Coinage metal complexes supported by a "PN(3)P" scaffold.

    Science.gov (United States)

    Rao, Gyandshwar Kumar; Gorelsky, Serge I; Korobkov, Ilia; Richeson, Darrin

    2015-11-28

    A series of monovalent group 11 complexes, [2,6-{Ph2PNMe}2(NC5H3)]CuBr 1, [2,6-{Ph2PNMe}2(NC5H3)]CuOTf 2, [2,6-{Ph2PNMe}2(NC5H3)]AgOTf 3, and [2,6-{Ph2PNMe}2(NC5H3)](AuCl)24, supported by a neutral PN(3)P ligand have been synthesized and characterized by multinuclear NMR and single crystal X-ray diffraction studies. The variation of the coordination properties were analyzed and electronic structure calculations have been carried out to provide insight on the bonding details in these complexes. The Cu(I) complexes displayed an unusual coordination geometry with a tridentate pincer ligand and an overall four coordinate trigonal pyramidal geometry. In contrast the Ag(I) analogue displayed a bidentate κ(2)-P,P' ligation leaving the pyridyl-N atom uncoordinated and yielding a pyramidalized trigonal planar geometry around Ag. The bimetallic Au(I) complex completed the series and displayed a monodentate P-bonded ligand and a linear coordination geometry.

  16. Lenalidomide as a disease-modifying agent in patients with del(5q) myelodysplastic syndromes: linking mechanism of action to clinical outcomes.

    Science.gov (United States)

    Giagounidis, Aristoteles; Mufti, Ghulam J; Fenaux, Pierre; Germing, Ulrich; List, Alan; MacBeth, Kyle J

    2014-01-01

    Deletion of the long arm of chromosome 5, del(5q), is the most prevalent cytogenetic abnormality in patients with myelodysplastic syndromes (MDS). In isolation, it is traditionally associated with favorable prognosis compared with other subtypes of MDS. However, owing to the inherent heterogeneity of the disease, prognosis for patients with del(5q) MDS is highly variable depending on the presence of factors such as additional chromosomal abnormalities, >5 % blasts in the bone marrow (BM), or transfusion dependence. Over recent years, the immunomodulatory drug lenalidomide has demonstrated remarkable efficacy in patients with del(5q) MDS. Advances in the understanding of the pathogenesis of the disease have suggested that lenalidomide targets aberrant signaling pathways caused by haplosufficiency of specific genes in a commonly deleted region on chromosome 5 (e.g., SPARC, RPS14, Cdc25C, and PP2A). As a result, the agent specifically targets del(5q) clones while also promoting erythropoiesis and repopulation of the bone marrow in normal cells. This review discusses recent developments in the understanding of the mechanism of action of lenalidomide, and how this underlies favorable outcomes in patients with del(5q) MDS. In addition, we discuss how improved understanding of the mechanism of disease will facilitate clinicians' ability to predict/monitor response and identify patients at risk of relapse.

  17. Plasma diagnostic potential of 2p4f in N$^+$ -- accurate wavelengths and oscillator strengths

    CERN Document Server

    Shen, Xiaozhi; Jönsson, Per; Wang, Jianguo

    2015-01-01

    Radiative emission lines from nitrogen and its ions are often observed in nebulae spectra, where the N$^{2+}$ abundance can be inferred from lines of the 2p4f configuration. In addition, intensity ratios between lines of the 2p3p -- 2p3s and 2p4f -- 2p3d transition arrays can serve as temperature diagnostics. To aid abundance determinations and plasma diagnostics, wavelengths and oscillator strengths were calculated with high-precision for electric-dipole (E1) transitions from levels in the 2p4f configuration of N$^{+}$. Electron correlation and relativistic effects, including the Breit interaction, were systematically taken into account within the framework of the multiconfiguration Dirac-Hartree-Fock (MCDHF) method. Except for the 2p4f - 2p4d transitions with quite large wavelengths and the two-electron-one-photon 2p4f -2s2p$^3$ transitions, the uncertainties of the present calculations were controlled to within 3% and 5% for wavelengths and oscillator strengths, respectively. We also compared our results w...

  18. A novel unbalanced de novo translocation der(5t(4;5(q26;q21.1 in adult T-cell precursor lymphoblastic leukemia

    Directory of Open Access Journals (Sweden)

    Kjeldsen Eigil

    2012-05-01

    Full Text Available Abstract We here describe a novel unbalanced de novo translocation der(5t(4;5(q26;q21.1 in a 39-year-old male diagnosed with acute T-cell lymphoblastic leukemia. Bone marrow (BM was massively infiltrated with 85 % highly proliferative polymorphic T-cell precursors. Immunologically, the malignant cells stained positive for CD7, CD34, intracytoplasmic CD3+, TdT + and negative for CD3 and CD5. G-banded chromosome analysis of BM cells showed the normal karyotype 46,XY[25] whereas BAC-based aCGH analysis revealed partial gain of 4q and partial loss of 5q. Multicolor karyotyping confirmed the presence of an unbalanced der(5t(4;5 as the sole structural abnormality. Subsequent high-resolution oligonucleotide-based aCGH analysis showed that the der(5t(4;5(q26;q21.1 resulted in partial trisomy of 4q26qter (117,719,015-190,613,014 and partial monosomy of 5q21.1qter (100,425,442-180,857,866 and that there was no indication of any gene disruptions resulting from the breakages. Interphase FISH analysis using BAC-based specific probes for 4q26 and 5q21.1 confirmed the breakpoints and revealed approximately 80 % abnormal cells accordingly. At 4q26 the MIR1973 gene is located centromeric to the breakpoint in the copy number neutral region and the TRAM1L1 gene is located within the gained region. At 5q21.1 the genes ST8SIA4 and MIR548p are located centromeric to the breakpoint and no known genes up to approximately 1 Mb telomeric to the breakpoint in the copy number loss region. Interestingly, only the gene ST8SIA4 at 5q21.1 have been implicated in T-cell regulation as it encodes one of the key enzymes for polysialysation of surface proteins on dendritic cells which are important regulators for T-cell proliferation. The der(5t(4;5 is thought to play a crucial role in the pathogenesis of acute T-ALL due to either gain of 4q, the loss of 5q, or deregulation of genes in proximity to the breakpoints.

  19. Spectra and oscillator strengths of 3p63d9-3p53d10 and 3p63d9-3p63d84p transitions for cobalt-like Sn23+ ion

    Institute of Scientific and Technical Information of China (English)

    Chen Ming-Lun; Yu Xiao-Guang

    2009-01-01

    This paper calculates the spectra and oscillator strengths for highly ionized cobalt-like Sn23+ ions 3p63d9-3p53d10,3p63d9 - 3p63d84p transitions by using a multi-configuration self-consistent field method program together with the proposed fitting formula. The calculations have a good agreement with observations.

  20. Oscillator strength for 3s{sup 2}3p{sup 5}-3s3p{sup 6} in Cl-like ions

    Energy Technology Data Exchange (ETDEWEB)

    Berrington, K.A.; Waldock, J.A. [School of Science and Mathematics, Sheffield Hallam University, Sheffield (United Kingdom); Pelan, J.C [Gatsby Computational Neuroscience Unit, University College, London (United Kingdom)

    2001-07-14

    Recent experiments have revealed discrepancies between calculated and experimental lifetimes in the lowest excited level of some chlorine-like ions. New ab initio oscillator strengths using the Breit-Pauli R-matrix method are provided for the 3s{sup 2}3p{sup 5} {sup 2}P{sup o}{sub 3/2,1/2}-3s3p{sup 6} {sup 2}S{sup e}{sub 1/2} transition in Cl-like Ar II through to Cu XIII. Our calculated lifetimes for these twelve ions are respectively 5.507, 2.077, 1.177, 0.784, 0.569, 0.438, 0.350, 0.287, 0.241, 0.206, 0.178 and 0.156 ns, and are more consistent with experiments than other calculations. (author). Letter-to-the-editor.

  1. Outcomes in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with isolated deletion 5q treated with lenalidomide: a subset analysis from the MDS-004 study

    Science.gov (United States)

    Giagounidis, Aristoteles; Mufti, Ghulam J; Mittelman, Moshe; Sanz, Guillermo; Platzbecker, Uwe; Muus, Petra; Selleslag, Dominik; Beyne-Rauzy, Odile; te Boekhorst, Peter; del Cañizo, Consuelo; Guerci-Bresler, Agnès; Nilsson, Lars; Lübbert, Michael; Quesnel, Bruno; Ganser, Arnold; Bowen, David; Schlegelberger, Brigitte; Göhring, Gudrun; Fu, Tommy; Benettaib, Bouchra; Hellström-Lindberg, Eva; Fenaux, Pierre

    2014-01-01

    Objective A subset analysis of the randomised, phase 3, MDS-004 study to evaluate outcomes in patients with International Prognostic Scoring System (IPSS)-defined Low-/Intermediate (Int)-1-risk myelodysplastic syndromes (MDS) with isolated del(5q). Methods Patients received lenalidomide 10 mg/d (days 1–21; n = 47) or 5 mg/d (days 1–28; n = 43) on 28-d cycles or placebo (n = 45). From the placebo and lenalidomide 5 mg groups, 84% and 58% of patients, respectively, crossed over to lenalidomide 5 or 10 mg at 16 wk, respectively. Results Rates of red blood cell-transfusion independence (RBC-TI) ≥182 d were higher in the lenalidomide 10 mg (57.4%; P < 0.0001) and 5 mg (37.2%; P = 0.0001) groups vs. placebo (2.2%). Cytogenetic response rates (major + minor responses) were 56.8% (P < 0.0001), 23.1% (P = 0.0299) and 0%, respectively. Two-year cumulative risk of acute myeloid leukaemia progression was 12.6%, 17.4% and 16.7% in the lenalidomide 10 mg, 5 mg, and placebo groups, respectively. In a 6-month landmark analysis, overall survival was longer in lenalidomide-treated patients with RBC-TI ≥182 d vs. non-responders (P = 0.0072). The most common grade 3–4 adverse event was myelosuppression. Conclusions These data support the clinical benefits and acceptable safety profile of lenalidomide in transfusion-dependent patients with IPSS-defined Low-/Int-1-risk MDS with isolated del(5q). PMID:24813620

  2. P2P Live Video Streaming

    OpenAIRE

    Chatzidrossos, Ilias

    2010-01-01

    The ever increasing demand for video content directed the focus of researchfrom traditional server-based schemes to peer-to-peer systems for videodelivery. In such systems, video data is delivered to the users by utilizing theresources of the users themselves, leading to a potentially scalable solution.Users connect to each other, forming a p2p overlay network on top of theInternet and exchange the video segments among themselves. The performanceof a p2p system is characterized by its capabil...

  3. P2P Techniques for Decentralized Applications

    CERN Document Server

    Pacitti, Esther

    2012-01-01

    As an alternative to traditional client-server systems, Peer-to-Peer (P2P) systems provide major advantages in terms of scalability, autonomy and dynamic behavior of peers, and decentralization of control. Thus, they are well suited for large-scale data sharing in distributed environments. Most of the existing P2P approaches for data sharing rely on either structured networks (e.g., DHTs) for efficient indexing, or unstructured networks for ease of deployment, or some combination. However, these approaches have some limitations, such as lack of freedom for data placement in DHTs, and high late

  4. Beam experiments with state selected Ne (3P0, 3P2) metastable atoms

    International Nuclear Information System (INIS)

    Metastable rare gas atoms play an important role in all types of plasmas and gas discharges, e.g. in fluorescent lamps and in laser discharges (helium-neon laser or excimer lasers). In this thesis, the metastable states of NeI are studied. First, the theory of excited neon atoms and diatomic molecules is introduced, as well as Penning ionisation. Next, some experimental facilities are described (e.g. the dye laser system). With these instruments, natural lifetime measurements of the 2p fine structure states of NeI are carried out. Results are reported. Finally, total Penning ionisation cross sections are calculated using the optical potential model. (Auth.)

  5. 5-Pentadecyl-2-((p-tolyliminomethylphenol

    Directory of Open Access Journals (Sweden)

    Amorn Petsom

    2013-07-01

    Full Text Available 5-Pentadecyl-2-((p-tolyliminomethylphenol has been synthesized by reaction of 2-hydroxy-4-pentadecylbenzaldehyde with 4-amino-1-methyl-aniline in 1,4-dioxane under reflux. The structure of the synthesized compound was assigned on the basis of elemental analysis, UV, IR, 1H-NMR, 13C-NMR and mass spectral data.

  6. 31 CFR 30.5 - Q-5: How does a TARP recipient comply with the requirements under § 30.4 (Q-4) of this part that...

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Q-5: How does a TARP recipient comply... recipient? 30.5 Section 30.5 Money and Finance: Treasury Office of the Secretary of the Treasury TARP STANDARDS FOR COMPENSATION AND CORPORATE GOVERNANCE § 30.5 Q-5: How does a TARP recipient comply with...

  7. Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML

    DEFF Research Database (Denmark)

    Treppendahl, Marianne Bach; Qiu, Xiangning; Søgaard, Alexandra;

    2012-01-01

    Deletions of chromosome 5q are associated with poor outcomes in acute myeloid leukemia (AML) suggesting the presence of tumor suppressor(s) at the locus. However, definitive identification of putative tumor suppressor genes remains controversial. Here we show that a 106-nucleotide noncoding RNA...

  8. Switch in FGFR3 and -4 expression profile during human renal development may account for transient hypercalcemia in patients with Sotos syndrome due to 5q35 microdeletions

    NARCIS (Netherlands)

    Mutsaers, H.A.M.; Levtchenko, E.N.; Martinerie, L.; Pertijs, J.C.L.M.; Allegaert, K.; Devriendt, K.; Masereeuw, R.; Monnens, L.A.; Lombes, M.

    2014-01-01

    CONTEXT: Sotos syndrome is a rare genetic disorder with a distinct phenotypic spectrum including overgrowth and learning difficulties. Here we describe a new case of Sotos syndrome with a 5q35 microdeletion, affecting the fibroblast growth factor receptor 4 (FGFR4) gene, presenting with infantile hy

  9. Mobile P2P Fast Similarity Search

    OpenAIRE

    Bocek, T; Hecht, F. V.; Hausheer, D; Hunt, E; Stiller, B.

    2009-01-01

    In informal data sharing environments, misspellings cause problems for data indexing and retrieval. This is even more pronounced in mobile environments, in which devices with limited input devices are used. In a mobile environment, similarity search algorithms for finding misspelled data need to account for limited CPU and bandwidth. This demo shows P2P fast similarity search (P2PFastSS) running on mobile phones and laptops that is tailored to uncertain data entry and use...

  10. Data Sharing in P2P Systems

    Science.gov (United States)

    Hayek, Rabab; Raschia, Guillaume; Valduriez, Patrick; Mouaddib, Noureddine

    In this chapter, we survey P2P data sharing systems. All along, we focus on the evolution from simple file-sharing systems, with limited functionalities, to Peer Data Management Systems (PDMS) that support advanced applications with more sophisticated data management techniques. Advanced P2P applications are dealing with semantically rich data (e.g., XML documents, relational tables), using a high-level SQL-like query language. We start our survey with an overview over the existing P2P network architectures, and the associated routing protocols. Then, we discuss data indexing techniques based on their distribution degree and the semantics they can capture from the underlying data. We also discuss schema management techniques which allow integrating heterogeneous data. We conclude by discussing the techniques proposed for processing complex queries (e.g., range and join queries). Complex query facilities are necessary for advanced applications which require a high level of search expressiveness. This last part shows the lack of querying techniques that allow for an approximate query answering.

  11. Atomic scattering in the diffraction limit: electron transfer in keV Li+-Na(3s, 3p) collisions

    DEFF Research Database (Denmark)

    Poel, Mike van der; Nielsen, C.V.; Rybaltover, M.;

    2002-01-01

    of the de Broglie wavelength lambda(dB) = 150 fm at a velocity v = 0.20 au and the effective atomic diameter for electron capture 2R = 20 au. Parallel AO and MO semiclassical coupled-channel calculations of the Na(3s, 3p) --> Li(2s, 2p) state-to-state collision amplitudes have been performed, and quantum...

  12. Electronic states of BP, BP +, BP -, B 2P 2, B2P2- and B2P2+

    Science.gov (United States)

    Linguerri, Roberto; Komiha, Najia; Oswald, Rainer; Mitrushchenkov, Alexander; Rosmus, Pavel

    2008-05-01

    Using augmented sextuple zeta basis sets and internally contracted multireference configuration interaction (MRCI) wavefunctions, potential energy, electric dipole and transition moments have been computed for the X 3Π, a 1Σ +, b 1Π and A 3Σ - states of BP, X 2Σ + and A 2Π states of BP - and X 4Σ - and A 4Π states of BP +. From these data spectroscopic constants, radiative transition probabilities and photoelectron spectra of BP - and BP have been evaluated. The non-vanishing spin-orbit coupling elements between the four low lying triplet and singlet states of the neutral BP have also been calculated from MRCI wavefunctions. The treatment of the corresponding perturbations in the manifold of dense rovibrational states in the three lowest states would require a precise knowledge of the electronic excitation energies. Our best singlet-triplet separations (X-a) are calculated to be 2412 cm -1 (MRCI) and 2482 cm -1 (restricted coupled cluster with perturbative triples (RCCSD(T))) with an estimated error bound of about ±200 cm -1. All three states have long radiative lifetimes with cascading among the rovibrational levels of different states. The ionization energy IE e of BP is calculated to be 9.22 eV (MRCI) and 9.48 eV (RCCSD(T)), the electron affinity EA e 2.51 eV (MRCI) and 2.74 eV (RCCSD(T)). The photoelectron spectra of BP and BP - have been obtained from the Franck-Condon factors of the MRCI potentials. For the UV spectroscopy the dipole allowed radiative transition probabilities are given for A 3Σ - ↔ X 3Π, b 1Π ↔ a 1Σ + of BP, A 2Π ↔ X 2Σ + of BP - and A 4Π ↔ X 4Σ - of BP +. The ionization energy IE e of B 2P 2 of 8.71 eV and the electron affinity EA e of 2.34 eV have been calculated by the RCCSD(T)/aVQZ approach. Also the harmonic vibrational wavenumbers for the electronic ground states of the ions B2P2+ and B2P2- are given.

  13. Cooling of Neutron Stars and 3P_2 neutron gap

    OpenAIRE

    Grigorian, H.; Voskresensky, D.N.(National Research Nuclear University (MEPhI), Moscow, 115409, Russia)

    2005-01-01

    We study the dependence of the cooling of isolated neutron stars on the magnitude of the $3P_2$ neutron gap. It is demonstrated that our ``Nuclear medium cooling scenario'' is in favor of a suppressed value of the $3P_2$ neutron gap.

  14. 3p - 3d intershell interaction in Cr

    International Nuclear Information System (INIS)

    The photoemission of Cr films deposited under UHV conditions has been investigated in the photon energy range from 30 eV to 230 eV. The 3p - 3d intershell interaction gives rise to a strong maximum in the 3d partial yield above the 3p threshold. (orig.) 891 KBE/orig. 892 RDG

  15. 5q14.3 deletion neurocutaneous syndrome: Contiguous gene syndrome caused by simultaneous deletion of RASA1 and MEF2C: A progressive disease.

    Science.gov (United States)

    Ilari, Rita; Agosta, Guillermo; Bacino, Carlos

    2016-03-01

    We report the case of a young girl who was presented with complex clinical symptoms caused by the deletion of contiguous genes: RASA1 and MEF2C, located on chromosome 5q14.3. Specifically, the diagnosis of her skin disorder and vascular malformations involving central nervous system is consistent with a RASopathy. The child's neurological manifestations are observed in most patients suffering from 5q14.3 by deletion or mutation of the MEF2C gene. A review of the literature allowed us to conclude that the contiguous deletion of genes RASA1 and MEF2C fulfills the criteria for the diagnosis of a Neurocutaneous syndrome as proposed by Carr et al. [2011]. We also assessed the penetrance of RASA1 and clinical manifestations of MEF2C according to the type of deletion. This child described presents the complete symptomatology of both deleted genes. We would also like to highlight the progression of the disorder.

  16. Monosomy 9p24{r_arrow}pter and trisomy 5q31{r_arrow}qter: Case report and review of two cases

    Energy Technology Data Exchange (ETDEWEB)

    Schimmenti, L.A.; Steinberger, J.; Mammel, M.C. [Univ. of Minnesota, Minneapolis, MN (United States)] [and others

    1995-05-22

    Partial deletion of the short arm of chromosome 9 (p24{r_arrow}pter) and partial duplication of the long arm of chromosome 5 (q32{r_arrow}qter) were observed in an abnormal boy who died at age 8 weeks of a complex cyanotic cardiac defect. He also had minor anomalies, sagittal craniosynostosis, triphalangeal thumbs, hypospadias, and a bifid scrotum. Two other infants with similar cytogenetic abnormalities were described previously. These patients had severe congenital heart defect, genitourinary anomalies, broad nasal bridge, low hairline, apparently low-set ears, short neck, and triphalangeal thumbs, in common with our patient. We suggest that combined monosomy 9q23,24{r_arrow}pter and trisomy 5q31,32{r_arrow}qter may constitute a clinically recognizable syndrome. 13 refs., 2 figs., 2 tabs.

  17. CCQE, 2p2h excitations and \

    CERN Document Server

    Nieves, J; Sánchez, F; Vacas, M J Vicente

    2013-01-01

    We analyze the MiniBooNE muon neutrino CCQE-like d\\sigma/dT_\\mu/dcos\\theta_\\mu data using a theoretical model that, among other nuclear effects, includes RPA correlations and 2p2h (multinucleon) mechanisms. These corrections turn out to be essential for the description of the data. We find that MiniBooNE CCQE-like data are fully compatible with former determinations of the nucleon axial mass M_A ~ 1.05 GeV. This is in sharp contrast with several previous analysis where anomalously large values of M_A ~ 1.4 GeV have been suggested. We also show that because of the the multinucleon mechanism effects, the algorithm used to reconstruct the neutrino energy is not adequate when dealing with quasielastic-like events. Finally, we analyze the MiniBooNE unfolded cross section, and show that it exhibits an excess (deficit) of low (high) energy neutrinos, which is an artifact of the unfolding process that ignores 2p2h mechanisms.

  18. A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk

    Directory of Open Access Journals (Sweden)

    Clark Susan

    2009-06-01

    Full Text Available Abstract Background Mitotic recombination is important for inactivating tumour suppressor genes by copy-neutral loss of heterozygosity (LOH. Although meiotic recombination maps are plentiful, little is known about mitotic recombination. The APC gene (chr5q21 is mutated in most colorectal tumours and its usual mode of LOH is mitotic recombination. Methods We mapped mitotic recombination boundaries ("breakpoints" between the centromere (~50 Mb and APC (~112 Mb in early colorectal tumours. Results Breakpoints were non-random, with the highest frequency between 65 Mb and 75 Mb, close to a low copy number repeat region (68–71 Mb. There were, surprisingly, few breakpoints close to APC, contrary to expectations were there constraints on tumorigenesis caused by uncovering recessive lethal alleles or if mitotic recombination were mechanistically favoured by a longer residual chromosome arm. The locations of mitotic and meiotic recombination breakpoints were correlated, suggesting that the two types of recombination are influenced by similar processes, whether mutational or selective in origin. Breakpoints were also associated with higher local G+C content. The recombination and gain/deletion breakpoint maps on 5q were not, however, associated, perhaps owing to selective constraints on APC dosage in early colorectal tumours. Since polymorphisms within the region of frequent mitotic recombination on 5q might influence the frequency of LOH, we tested the 68–71 Mb low copy number repeat and nearby tagSNPs, but no associations with colorectal cancer risk were found. Conclusion LOH on 5q is non-random, but local factors do not greatly influence the rate of LOH at APC or explain inter differential susceptibility to colorectal tumours.

  19. Assignment of human sprouty 4 gene to chromosome segment 5q32∼33 and analysis of its pattern of expression

    Indian Academy of Sciences (India)

    Hua Liu; Jin-Zhong Chen; Shao-Hua Gu; Jian-Liang Dai; En-Pang Zhao; Lu Huang; Wang-Xiang Xu; Yi Xie; Yu-Min Mao

    2003-04-01

    The human sprouty 4 (SPYR4) gene was localized to chromosome band 5q32∼33 by screening the Stanford radiation hybrid G3 panel using a SPRY4-specific primer pair for PCR. Northern blot analysis revealed two different mRNAs (5 kb and 2 kb) in liver, skeletal muscle, heart, lung, kidney, spleen, placenta and small intestine. Reverse transcriptase-PCR analysis showed that SPYR4 was expressed in all tested tissues to different levels.

  20. The human and mouse receptors of hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11

    Energy Technology Data Exchange (ETDEWEB)

    Spicer, A.P.; McDonald, J.A. [Mayo Clinic Scottsdale, AZ (United States); Roller, M.L.; Camper, S.A. [Univ. of Michigan Medical School, Ann Arbor, MI (United States)] [and others

    1995-11-01

    The gene for the receptor for hyaluronan-mediated motility, RHAAM (designated hyaluronan-mediated motility receptor, HMMR (human) and Hmmr (mouse), for mapping purposes), was localized to human chromosome 5q33.2-qter by somatic cell and radiation hybrid analyses. Investigation of two interspecific back-crosses localized the mouse RHAMM (Hmmr) locus 18 cM from the centromere of mouse chromosome 11 within a region of synteny homology with human chromosome 5q23-q35 genes. The map position of the human RHAMM gene places it in a region comparatively rich in disease-associated genes, including those for low-frequency hearing loss, dominant limb-girdle muscular dystrophy, diastrophic dysplasia, Treacher Collins syndrome, and myeloid disorders associated with the 5q-syndrome. The RHAMM gene location and its ability to transform cells when overexpressed implicate RHAMM as a possible candidate gene in the pathogenesis of the recently described t(5;14)(q33-q34;q11) acute lymphoblastic leukemias. 18 refs., 1 fig.

  1. Intercombination decay of 3s3p3P10 in Mg I-like Ni and Cu

    International Nuclear Information System (INIS)

    The intercombination transition 3s21S0-3s3p 3p10 in Ni16+ and Cu17+ has been studied by beam-foil spectroscopic methods. Decay curve analysis yields lifetime values of (12.0+-1.0) ns and (8.8+-0.6) ns for Ni and Cu in agreement with various predictions. (orig./WL)

  2. WAVELENGTHS OF THE 3p-3d TRANSITIONS OF THE Co- AND Fe-LIKE IONS : THE EFFECTS OF ELECTRON CORRELATION

    OpenAIRE

    Chen, M.

    1988-01-01

    The experimental observations of the 3p6 3d9 2D - 3p5 3dl0 2p transitions of the Co-like ions and 3p6 3d8 3F4 - 3p5 3d9 3F3 of the Fe-like ions have recently been extended to highly charged ions of heavy elements up to uranium (Z = 92). A comparison between the observed energies and calculated values from the Dirac-Fock model indicated persistent diicrepancies of 3-4 eV for al1 ions. Systematic multiconfiguration Dirac-Fock caiculations for these transitions have been carried out with emphasi...

  3. Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1

    DEFF Research Database (Denmark)

    Glubb, Dylan M; Maranian, Mel J; Michailidou, Kyriaki;

    2015-01-01

    Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt to identify the biologically relevant variants, we analyzed 909 genetic variants across 5q11.2 in 103,991 breast cancer individuals an...

  4. 75 FR 23574 - Airworthiness Directives; CFM International, S.A. CFM56-5B1/P, -5B2/P, -5B3/P, -5B3/P1, -5B4/P...

    Science.gov (United States)

    2010-05-04

    ... INFORMATION: The FAA proposed to amend 14 CFR part 39 by superseding AD 2009-01-01, Amendment 39-15779 (73 FR... (74 FR 67834). That action proposed to require continuous monitoring of EGT margin deterioration... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and (3) Will not have a...

  5. Energy levels and radiative lifetimes of 3pns 3P0 and 3pnd 3P0 series of Si I

    Institute of Scientific and Technical Information of China (English)

    Liang Liang; Chao Zhou; Ling Zhang

    2008-01-01

    The energy levels and lifetimes of 3pns 3P0 (n=7-35) and 3pnd 3P0(n=6-17) series of neutral silicon are calculated and predicted by means of multichannel quantum defect theory (MQDT). In addition, the perturbation caused by core-excited state 3s3p3 is discussed. The 3pnd 3P0 series, especially 3p4d 3P0,3p5d 3P0 and 3p6d 3P0 are perturbed strongly by the core-excited state 3s3p3 3P0. These cause the lifetime of 3pnd 3P0 (n=5-7) to be less than that of 3p4d 3P0. The lifetimes of 3p14d 3P0 (65479.14 cm-1) and 3p16d 3P0 (65608.77 cm-1) are less than that of their frontal states respectively, because these states are perturbed by 3p22s 3P0 (65476.48 cm-1) and 3p30s 3P0 (65608.99 cm-1) respectively.

  6. Where are $\\chi_{cJ}(3P)$?

    CERN Document Server

    Chen, Dian-Yong

    2016-01-01

    In the present work, we propose the $Y(4140)$ as the $\\chi_{c1}(3P)$ state by studying the $\\chi_{c1} \\pi^+ \\pi^-$ invariant mass spectrum of the $B\\to K \\chi_{c1} \\pi^+ \\pi^-$ process. In the $D\\bar{D}$ invariant mass spectrum of the $B\\to K D\\bar{D}$ process, we find a new resonance with the mass and width to be $ (4083.0 \\pm 5.0) $ and $ (24.1 \\pm 15.4) $ MeV, respectively, which could be a good candidate of the $\\chi_{c0}(3P)$ state. The theoretical investigations on the decay behaviors of the $\\chi_{cJ}(3P)$ in the present work support the assignments of the $Y(4140)$ and $Y(4080)$ as the $\\chi_{c1}(3P)$ and $\\chi_{c0}(3P)$ states, respectively. In addition, the $\\chi_{c2}(3P)$ state is predicted to be a very narrow state. The results in the present work could be tested by further experiments in the LHCb and forthcoming Belle II.

  7. The ViP2P Platform: XML Views in P2P

    CERN Document Server

    Karanasos, Konstantinos; Manolescu, Ioana; Zoupanos, Spyros

    2011-01-01

    The growing volumes of XML data sources on the Web or produced by enterprises, organizations etc. raise many performance challenges for data management applications. In this work, we are concerned with the distributed, peer-to-peer management of large corpora of XML documents, based on distributed hash table (or DHT, in short) overlay networks. We present ViP2P (standing for Views in Peer-to-Peer), a distributed platform for sharing XML documents based on a structured P2P network infrastructure (DHT). At the core of ViP2P stand distributed materialized XML views, defined by arbitrary XML queries, filled in with data published anywhere in the network, and exploited to efficiently answer queries issued by any network peer. ViP2P allows user queries to be evaluated over XML documents published by peers in two modes. First, a long-running subscription mode, when a query can be registered in the system and receive answers incrementally when and if published data matches the query. Second, queries can also be asked...

  8. Ruthenium hydrides containing the superhindered polydentate polyphosphine ligand P(CH2CH2P(t)Bu2)3.

    Science.gov (United States)

    Gilbert-Wilson, Ryan; Field, Leslie D; Bhadbhade, Mohan

    2014-12-01

    The complex RuH2(N2)(P(2)P3(tBu)) (1) containing the extremely bulky PP3-type ligand P(2)P3(tBu) = P(CH2CH2P(t)Bu2)3 was synthesized by reduction of RuCl2(P(2)P3(tBu)) (2) with Na/NH3 under a N2 atmosphere. Like other complexes containing the P(2)P3(tBu) ligand, only three of the four donor phosphines are coordinated, and one of the phosphines remains as a dangling pendant phosphine. Reduction of RuCl2(P(2)P3(tBu)) (2) with a range of the more usual hydride reducing agents afforded the previously unknown ruthenium hydride complexes RuHCl(P(2)P3(tBu)) (3), RuH(BH4)(P(2)P3(tBu)) (6), RuH(AlH4)(P(2)P3(tBu)) (7), and the ruthenium(II) trihydride K[Ru(H)3(P(2)P3(tBu))] (8). The ruthenium tetrahydride containing a coordinated H2 ligand RuH2(H2)(P(2)P3(tBu)) (10) was synthesized by exchange of N2 in 1 by H2. Complexes 1, 3, 6, 7, and 8 were characterized by crystallography and multinuclear NMR spectroscopy. PMID:25390508

  9. Narrowing the position of the Treacher Collins syndrome locus to a small interval between three new microsatellite markers at 5q32-33. 1

    Energy Technology Data Exchange (ETDEWEB)

    Dixon, M.J.; Dixon, J. (Univ. of Manchester (United Kingdom)); Houseal, T.; Klinger, K.; Landes, G.M. (Integrated Genetics, Inc., Framingham, MA (United States)); Bhatt, M.; Ward, D.C. (Yale Univ. School of Medicine, New Haven (United States))

    1993-05-01

    Treacher Collins syndrome (TCOF1) is an autosomal dominant disorder of craniofacial development, the features of which include conductive hearing loss and cleft palate. The TCOF1 locus has been localized to chromosome 5q32-33.2. In the present study the authors have used the combined techniques of genetic linkage analysis and fluorescence in situ hybridization (FISH) to more accurately define the TCOF1 critical region. Cosmids IG90 and SPARC, which map to distal 5q, encompass two and one hypervariable microsatellite markers, respectively. The heterozygosity values of these three markers range from .72 to .81. Twenty-two unrelated TCOF1 families have been analyzed for linkage to these markers. There is strong evidence demonstrating linkage to all three markers, the strongest support for positive linkage being provided by haplotyping those markers at the locus encompassed by the cosmid IG90 (Z[sub max]= 19.65; 0 = .010). FISH to metaphase chromosomes and interphase nuclei established that IG90 lies centromeric to SPARC. This information combined with the data generated by genetic linkage analysis demonstrated that the TCOF1 locus is closely flanked proximally by IG90 and distally by SPARC. 30 refs., 2 figs., 4 tabs.

  10. A physical map of 15 loci on human chromosome 5q23-q33 by two-color fluorescence in situ hybridization

    Energy Technology Data Exchange (ETDEWEB)

    Saltman, D.L.; Dolganov, G.M. (Genelabs Inc. Redwood City, CA (United States)); Warrington, J.A.; Wasmuth, J.J. (Univ. of California, Irvine (United States)); Lovett, M. (Univ. of Texas Southwestern Medical Center, Dallas (United States))

    1993-06-01

    The q23-q33 region of human chromosome 5 encodes a large number of growth factors, growth factor receptors, and hormone/neurotransmitter receptors. This is also the general region into which several disease genes have been mapped, including diastrophic dysplasia, Treacher Collins syndrome, hereditary startle disease, the myeloid disorders that are associated with the 5q-syndrome, autosomal-dominant forms of hereditary deafness, and limb girdle muscular dystrophy. The authors have developed a framework physical map of this region using cosmid clones isolated from the Los Alamos arrayed chromosome 5-specific library. Entry points into this library included 14 probes to genes within this interval and one anonymous polymorphic marker locus. A physical map has been constructed using fluorescence in situ hybridization of these cosmids on metaphase and interphase chromosomes, and this is in good agreement with the radiation hybrid map of the region. The derived order of loci across the region is cen-IL4-IL5-IRF1-IL3-IL9-EGR1-CD14-FGFA-GRL-D5S207-ADRB2-SPARC-RPS14-CSF1R-ADRA1, and the total distance spanned by these loci is approximately 15 Mb. The framework map, genomic clones, and contig expansion within 5q23-q33 should provide valuable resources for the eventual isolation of the clinically relevant loci that reside in this region. 31 refs., 3 figs., 2 tabs.

  11. P2P IPTV Measurement: A Comparison Study

    OpenAIRE

    Silverston, Thomas; Fourmaux, Olivier

    2006-01-01

    With the success of P2P file sharing, new emerging P2P applications arise on the Internet for streaming content like voice (VoIP) or live video (IPTV). Nowadays, there are lots of works measuring P2P file sharing or P2P telephony systems, but there is still no comprehensive study about P2P IPTV, whereas it should be massively used in the future. During the last FIFA world cup, we measured network traffic generated by P2P IPTV applications like PPlive, PPstream, TVants and Sopcast. In this pap...

  12. Main: 1M2P [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available 1M2P トウモロコシ Corn Zea mays L. Casein Kinase Ii, Alpha Chain Name=Ack2; Zea Mays Mole...LVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQVRAAENSRTRA corn_1M2P.jpg ...

  13. Spatial and electronic structure of the Ni3P surface

    International Nuclear Information System (INIS)

    To understand the catalytic effect in the Ni-Ni3P for the growth of carbon nanostructures, the structural and electronic properties of Ni3P surface are calculated from first-principles calculations. The calculated surface energies for the (0 0 1)-Ni4P4-terminated surface, the (0 0 1)-Ni8-terminated surface, and the (1 1 0)-Ni8-terminated surface show that the (0 0 1)-Ni4P4-terminated surface is energetically more stable within the allowed range of the chemical potential of P. Through the analysis of the partial density of states of Ni and P atoms in surface and bulk states, respectively, it is further found that due to the bond contractions of the surface layer, the core-level shifts of P atoms in the (0 0 1)-Ni4P4-terminated surface make P atoms in the Ni3P particles act as a catalyst. Finally, the obtained results of the work function show that the (0 0 1)-Ni4P4-terminated surface has the largest work function when compared with the other two studied surfaces.

  14. The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human Chromosome 5q23 and a syntenic region of mouse chromosome 13

    Energy Technology Data Exchange (ETDEWEB)

    Bram, R.J.; Valentine, V.; Shapiro, D.N. [St. Jude Children`s Research Hospital, Memphis, TN (United States)]|[Univ. of Tennessee, Memphis, TN (United States)] [and others

    1996-01-15

    The CAMLG gene encodes a novel cyclophilin B-binding protein called calcium-modulating cyclophilin ligand, which appears to be involved in the regulation of calcium signaling in T lymphocytes and other cells. The murine homolog, Caml, was localized by interspecific backcross analysis in the middle of chromosome 13. By fluorescence in situ hybridization, this gene was localized to human chromosome 5 in a region (q23) known to be syntenic to mouse chromosome 13. These results provide further evidence supporting the extensive homology between human chromosome 5q and mouse chromosome 13. In addition, the results will provide a basis for further evaluation of cytogenetic anomalies that may contribute to inherited defects in calcium signaling or immune system function. 15 refs., 2 figs.

  15. Myelodysplastic disorders carrying both isolated del(5q) and JAK2(V617F) mutation: concise review, with focus on lenalidomide therapy.

    Science.gov (United States)

    Musto, Pellegrino; Simeon, Vittorio; Guariglia, Roberto; Bianchino, Gabriella; Grieco, Vitina; Nozza, Filomena; La Rocca, Francesco; Marziano, Gioacchino; Lalinga, Anna Vittoria; Fabiani, Emiliano; Voso, Maria Teresa; Scaravaglio, Patrizia; Mecucci, Cristina; D'Arena, Giovanni

    2014-01-01

    The concomitant presence of del(5q) and JAK2(V617F) mutation is an infrequent event which occurs in rare patients with peculiar cytogenetic, molecular, morphological and clinical features, resembling those of both myelodysplastic syndromes and myeloproliferative neoplasms. Lenalidomide may induce rapid, profound, and long-lasting responses in a subset of these patients. However, the mechanism(s) by which the drug acts in these conditions remain not completely elucidated. A new case report and a review of all cases published so far in this setting are provided. Furthermore, the possibility of categorizing - from a clinical, pathological, and biological point of view - for at least some of these patients as a potential distinct entity is discussed.

  16. Myelodysplastic disorders carrying both isolated del(5q) and JAK2V617F mutation: concise review, with focus on lenalidomide therapy

    Science.gov (United States)

    Musto, Pellegrino; Simeon, Vittorio; Guariglia, Roberto; Bianchino, Gabriella; Grieco, Vitina; Nozza, Filomena; La Rocca, Francesco; Marziano, Gioacchino; Lalinga, Anna Vittoria; Fabiani, Emiliano; Voso, Maria Teresa; Scaravaglio, Patrizia; Mecucci, Cristina; D’Arena, Giovanni

    2014-01-01

    The concomitant presence of del(5q) and JAK2V617F mutation is an infrequent event which occurs in rare patients with peculiar cytogenetic, molecular, morphological and clinical features, resembling those of both myelodysplastic syndromes and myeloproliferative neoplasms. Lenalidomide may induce rapid, profound, and long-lasting responses in a subset of these patients. However, the mechanism(s) by which the drug acts in these conditions remain not completely elucidated. A new case report and a review of all cases published so far in this setting are provided. Furthermore, the possibility of categorizing – from a clinical, pathological, and biological point of view – for at least some of these patients as a potential distinct entity is discussed. PMID:24966686

  17. Lenalidomide for the Treatment of Low- or Intermediate-1-Risk Myelodysplastic Syndromes Associated with Deletion 5q Cytogenetic Abnormality: An Evidence Review of the NICE Submission from Celgene.

    Science.gov (United States)

    Blommestein, Hedwig M; Armstrong, Nigel; Ryder, Steve; Deshpande, Sohan; Worthy, Gill; Noake, Caro; Riemsma, Rob; Kleijnen, Jos; Severens, Johan L; Al, Maiwenn J

    2016-01-01

    The National Institute for Health and Care Excellence (NICE) invited the manufacturer of lenalidomide (Celgene) to submit evidence of the clinical and cost effectiveness of the drug for treating adults with myelodysplastic syndromes (MDS) associated with deletion 5q cytogenetic abnormality, as part of the Institute's single technology appraisal (STA) process. Kleijnen Systematic Reviews Ltd (KSR), in collaboration with Erasmus University Rotterdam, was commissioned to act as the Evidence Review Group (ERG). This paper describes the company's submission, the ERG review, and the NICE's subsequent decisions. The ERG reviewed the evidence for clinical and cost effectiveness of the technology, as submitted by the manufacturer to the NICE. The ERG searched for relevant additional evidence and validated the manufacturer's decision analytic model to examine the robustness of the cost-effectiveness results. Clinical effectiveness was obtained from a three-arm, European, randomized, phase III trial among red blood cell (RBC) transfusion-dependent patients with low-/intermediate-1-risk del5q31 MDS. The primary endpoint was RBC independence for ≥26 weeks, and was reached by a higher proportion of patients in the lenalidomide 10 and 5 mg groups compared with placebo (56.1 and 42.6 vs 5.9 %, respectively; both p submitted a Patient Access Scheme (PAS) that provided lenalidomide free of charge for patients who remained on treatment after 26 cycles. This PAS improved the ICER to £25,300, although the AC considered the proportion of patients who received treatment beyond 26 cycles, and hence the ICER, to be uncertain. Nevertheless, the AC accepted a commitment from the manufacturer to publish, once available, data on the proportion of patients eligible for the PAS, and believed this provided reassurance that lenalidomide was a cost-effective treatment for low- or intermediate-1-risk MDS patients. PMID:26314282

  18. Myelodysplastic disorders carrying both isolated del(5q and JAK2V617F mutation: concise review, with focus on lenalidomide therapy

    Directory of Open Access Journals (Sweden)

    Musto P

    2014-06-01

    Full Text Available Pellegrino Musto,1 Vittorio Simeon,2 Roberto Guariglia,3 Gabriella Bianchino,4 Vitina Grieco,4 Filomena Nozza,4 Francesco La Rocca,2 Gioacchino Marziano,1 Anna Vittoria Lalinga,5 Emiliano Fabiani,6 Maria Teresa Voso,6 Patrizia Scaravaglio,7 Cristina Mecucci,8 Giovanni D'Arena31Scientific Direction, 2Laboratory of Preclinical and Translational Research, 3Unit of Hematology and Stem Cell Transplantation, 4Laboratory of Clinical Research and Advanced Diagnostics, 5Pathology Unit, IRCCS, Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy; 6Department of Hematology, Universita Cattolica del Sacro Cuore, Rome, Italy; 7Laboratory of Internal Medicine and Hematology, S Luigi Gonzaga Hospital, Orbassano, Italy; 8Hematology and Bone Marrow Transplantation Unit, University of Perugia, Perugia, ItalyAbstract: The concomitant presence of del(5q and JAK2V617F mutation is an infrequent event which occurs in rare patients with peculiar cytogenetic, molecular, morphological and clinical features, resembling those of both myelodysplastic syndromes and myeloproliferative neoplasms. Lenalidomide may induce rapid, profound, and long-lasting responses in a subset of these patients. However, the mechanism(s by which the drug acts in these conditions remain not completely elucidated. A new case report and a review of all cases published so far in this setting are provided. Furthermore, the possibility of categorizing – from a clinical, pathological, and biological point of view – for at least some of these patients as a potential distinct entity is discussed.Keywords: myelodysplastic syndromes, myeloproliferative neoplasms, lenalidomide, del(5q, JAK2, World Health Organization

  19. Genetic and physical mapping of the Treacher Collins syndrome locus with respect to loci in the chromosome 5q3 region

    Energy Technology Data Exchange (ETDEWEB)

    Jabs, E.W.; Li, Xiang; Coss, C.; Taylor, E. (Johns Hopkins School of Medicine, Baltimore, MD (United States)); Lovett, M. (Univ. of Texas Southwestern Medical Center, San Antonio, TX (United States)); Yamaoka, L.H.; Speer, M.C. (Duke Univ. Medical Center, Durham, NC (United States)); Cadle, R.; Hall, B. (Univ. of Kentucky, Lexington, KY (United States)); Brown, K. (Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY (United States)) (and others)

    1993-10-01

    Treacher Collins syndrome is an autosomal dominant, craniofacial developmental disorder, and its locus (TCOF1) has been mapped to chromosome 5q3. To refine the location of the gene within this region, linkage analysis was performed among the TCOF1 locus and 12 loci (IL9, FGFA, GRL, D5S207, D5S210, D5S376, CSF1R, SPARC, D5S119, D5S209, D5S527, FGFR4) in 13 Treacher Collins syndrome families. The highest maximum lod score was obtained between loci TCOF1 and D5S210 (Z = 10.52; [theta] = 0.02 [+-] 0.07). The best order, IL9-GRL-D5S207/D5S210-CSF1R-SPARC-D5S119, and genetic distances among these loci were determined in the 40 CEPH families by multipoint linkage analysis. YAC clones were used to establish the order of loci, centromere-5[prime]GRL3[prime]-D5S207-D5S210-D5S376-CSF1R-SPARC-D5S119-telomere. By combining known physical mapping data with ours, the order of chromosome 5q3 markers is centomere-IL9-FGFA-5[prime]GRL3[prime]-D5s207-D5S210-D5S376-CSF1R-SPARC-D5S119-D5S209-FGFR4-telomere. Based on this order, haplotype analysis suggests that the TCOF1 locus resides distal CSF1R and proximal to SPARC within a region less than 1 Mb in size. 29 refs., 2 figs., 2 tabs.

  20. Modeling Load Balancing in Heterogeneous Unstructured P2P Systems

    Directory of Open Access Journals (Sweden)

    Zhi J. Li

    2005-01-01

    Full Text Available Load balancing is a generally concerned problem in peer-to-peer (P2P systems. Many researches on load balancing in the structured P2P systems have been launched currently, such as Chord or other DHTs. Although the researches on load balancing in unstructured P2P systems are emerged nowadays, the simple mechanisms achieved can only perform effectively in uniform environment. In this study, the influence on load balancing of the heterogeneity existed universally in unstructured P2P systems are analyzed, the unstructured P2P systems and their load balancing and the heterogeneity are modeled. Based on the formal model, the load balancing is analyzed quantitatively under static and dynamic environment and the typical load balancing algorithms are also analyzed. Some important conclusions are drawn which can be used in new models of load balancing in unstructured P2P systems.

  1. Research and Development of P2P Worms

    Institute of Scientific and Technical Information of China (English)

    Li You; Zhi-Guang Qin

    2011-01-01

    With the development and the application of many popular peer-to-peer (P2P) systems such as eMule and BitTorrent,worms probably employ the features of these P2P networks to put them at risk.Some features,such as the local routing table and the application routing mechanism,are helpful to quickly distribute the P2P worms into the networks.This paper aims to give a comprehensive survey of P2P worms.The definition and the classification of P2P worms are discussed firstly.Then,the research and development of P2P worms, including experimental analysis,propagation modeling,and defensive approaches,are addressed and analyzed in detail.

  2. Products of the Benzene + O(3P) Reaction

    Energy Technology Data Exchange (ETDEWEB)

    Taatjes, Craig A.; Osborn, David L.; Selby, Talitha M.; Meloni, Giovanni; Trevitt, Adam J.; Epifanovsky, Evgeny; Krylov, Anna I.; Sirjean, Baptiste; Dames, Enoch; Wang, Hai

    2009-12-21

    The gas-phase reaction of benzene with O(3P) is of considerable interest for modeling of aromatic oxidation, and also because there exist fundamental questions concerning the prominence of intersystem crossing in the reaction. While its overall rate constant has been studied extensively, there are still significant uncertainties in the product distribution. The reaction proceeds mainly through the addition of the O atom to benzene, forming an initial triplet diradical adduct, which can either dissociate to form the phenoxy radical and H atom, or undergo intersystem crossing onto a singlet surface, followed by a multiplicity of internal isomerizations, leading to several possible reaction products. In this work, we examined the product branching ratios of the reaction between benzene and O(3P) over the temperature range of 300 to 1000 K and pressure range of 1 to 10 Torr. The reactions were initiated by pulsed-laser photolysis of NO2 in the presence of benzene and helium buffer in a slow-flow reactor, and reaction products were identified by using the multiplexed chemical kinetics photoionization mass spectrometer operating at the Advanced Light Source (ALS) of Lawrence Berkeley National Laboratory. Phenol and phenoxy radical were detected and quantified. Cyclopentadiene and cyclopentadienyl radical were directly identified for the first time. Finally, ab initio calculations and master equation/RRKM modeling were used to reproduce the experimental branching ratios, yielding pressure-dependent rate expressions for the reaction channels, including phenoxy + H, phenol, cyclopentadiene + CO, which are proposed for kinetic modeling of benzene oxidation.

  3. P2P worm detection based on application identification

    Institute of Scientific and Technical Information of China (English)

    XIA Chunhe; SHI Yunping; LI Xiaojian; GAO Wei

    2007-01-01

    P2P worm exploits common vulnerabilities and spreads through peer-to-peer networks.Despite being recognized as a potential and deadly threat to the Internet recently,few relevant countermeasures are found in extant literature.Once it breaks out,a P2P worm could result in unpredictable losses.Based on propagation characteristics of the worm,this paper presents a detection method called PWD (P2P Worm Detection),which is designed based on application identification and unknown worm detection.Simulation result and LAN-environment experiment result both indicate that PWD is an effective method to detect and block P2P worms.

  4. Search by shortcuts in P2P scientific collaboration system

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    A P2P scientific collaboration is a P2P network whose members can share documents, co-compile papers and codes, and communicate with each other instantly. From the simulation experiment we found that P2P collaboration system is a power-law network with a tail between -2 and -3.We utilized the algorithm that searches by high-degree shortcuts to improve the scalability of p2p collaboration system. The experimental result shows that the algorithm works better than random walk algorithm.

  5. Transition probabilities for NII 2p4f-2p3d and 2s2p23d-2s2p23p obtained by a semiclassical method

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Based on NII spectra, some transition probabilities for 2p4f-2p3d and 2s2p23d-2s2p23p are obtained by a semiclassical method. The results are in good agreement with other measurements and the data reported by the National Institute of Standards and Technology. The transition probability for a line of 424.18nm is reported for the first time. Meanwhile, a feasible method of calculating transition parameters related to special excited configurations or highly excited states is provided.

  6. 伴有t(3;5)(q25;q34)的骨髓增生异常综合征急性髓系白血病变患者的分子特征%Molecular characterization of t (3;5)(q25;q34) in a case of acute myeloid leukemia secondary to myelodysplastic syndromes

    Institute of Scientific and Technical Information of China (English)

    张悦; 邵英起; 薛永权; 王一; 张美荣; 刘旭平; 郑以州; 肖志坚

    2006-01-01

    目的 研究t(3;5)(q25;q34)的分子特征.方法 R显带染色体核型分析和染色体涂染分析确定t(3;5)(q25;q34)存在.RT-PCR法检测患者NPM-MLF1融合基因、MLF1基因表达.PCR联合序列分析检测NPM基因突变.实时定量RT-PCR(Real-time PCR)检测Evi-1,MDS1/Evi-1表达.免疫组化染色确定MLF1和NPM-MLF1蛋白细胞定位分布.Western blot法检测bcl-2蛋白表达.结果 染色体核型分析和涂染分析均证实存在染色体t(3;5)(q25;q34),NPM-MLF1融合基因阳性,经诱导治疗获得完全缓解后转为阴性.患者白血病细胞仅表达MLF1基因非编码蛋白剪接体,不表达Evi-1基因,弱表达MDS1/Evi-1.无NPM基因突变,未检出bcl-2蛋白表达.MLF1蛋白定位于细胞质,而NPM-MLF1则主要定位于胞核.结论 t(3;5)(q25;q34)是髓系肿瘤的一种少见的染色体易位,该染色体易位导致形成NPM-MLF1融合基因是其发病的分子学基础.

  7. Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1

    Science.gov (United States)

    Glubb, Dylan M.; Maranian, Mel J.; Michailidou, Kyriaki; Pooley, Karen A.; Meyer, Kerstin B.; Kar, Siddhartha; Carlebur, Saskia; O’Reilly, Martin; Betts, Joshua A.; Hillman, Kristine M.; Kaufmann, Susanne; Beesley, Jonathan; Canisius, Sander; Hopper, John L.; Southey, Melissa C.; Tsimiklis, Helen; Apicella, Carmel; Schmidt, Marjanka K.; Broeks, Annegien; Hogervorst, Frans B.; van der Schoot, C. Ellen; Muir, Kenneth; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Fasching, Peter A.; Ruebner, Matthias; Ekici, Arif B.; Beckmann, Matthias W.; Peto, Julian; dos-Santos-Silva, Isabel; Fletcher, Olivia; Johnson, Nichola; Pharoah, Paul D.P.; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Burwinkel, Barbara; Marme, Frederik; Yang, Rongxi; Surowy, Harald; Guénel, Pascal; Truong, Thérèse; Menegaux, Florence; Sanchez, Marie; Bojesen, Stig E.; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; González-Neira, Anna; Benitez, Javier; Zamora, M. Pilar; Arias Perez, Jose Ignacio; Anton-Culver, Hoda; Neuhausen, Susan L.; Brenner, Hermann; Dieffenbach, Aida Karina; Arndt, Volker; Stegmaier, Christa; Meindl, Alfons; Schmutzler, Rita K.; Brauch, Hiltrud; Ko, Yon-Dschun; Brüning, Thomas; Nevanlinna, Heli; Muranen, Taru A.; Aittomäki, Kristiina; Blomqvist, Carl; Matsuo, Keitaro; Ito, Hidemi; Iwata, Hiroji; Tanaka, Hideo; Dörk, Thilo; Bogdanova, Natalia V.; Helbig, Sonja; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Wu, Anna H.; Tseng, Chiu-chen; Van Den Berg, David; Stram, Daniel O.; Lambrechts, Diether; Zhao, Hui; Weltens, Caroline; van Limbergen, Erik; Chang-Claude, Jenny; Flesch-Janys, Dieter; Rudolph, Anja; Seibold, Petra; Radice, Paolo; Peterlongo, Paolo; Barile, Monica; Capra, Fabio; Couch, Fergus J.; Olson, Janet E.; Hallberg, Emily; Vachon, Celine; Giles, Graham G.; Milne, Roger L.; McLean, Catriona; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Simard, Jacques; Goldberg, Mark S.; Labrèche, France; Dumont, Martine; Teo, Soo Hwang; Yip, Cheng Har; See, Mee-Hoong; Cornes, Belinda; Cheng, Ching-Yu; Ikram, M. Kamran; Kristensen, Vessela; Zheng, Wei; Halverson, Sandra L.; Shrubsole, Martha; Long, Jirong; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Kauppila, Saila; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Tchatchou, Sandrine; Devilee, Peter; Tollenaar, Robert A.E.M.; Seynaeve, Caroline; Van Asperen, Christi J.; García-Closas, Montserrat; Figueroa, Jonine; Chanock, Stephen J.; Lissowska, Jolanta; Czene, Kamila; Klevebring, Daniel; Darabi, Hatef; Eriksson, Mikael; Hooning, Maartje J.; Hollestelle, Antoinette; Martens, John W.M.; Collée, J. Margriet; Hall, Per; Li, Jingmei; Humphreys, Keith; Shu, Xiao-Ou; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Cox, Angela; Cross, Simon S.; Reed, Malcolm W.R.; Blot, William; Signorello, Lisa B.; Cai, Qiuyin; Shah, Mitul; Ghoussaini, Maya; Kang, Daehee; Choi, Ji-Yeob; Park, Sue K.; Noh, Dong-Young; Hartman, Mikael; Miao, Hui; Lim, Wei Yen; Tang, Anthony; Hamann, Ute; Torres, Diana; Jakubowska, Anna; Lubinski, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; McKay, James; Olswold, Curtis; Slager, Susan; Toland, Amanda E.; Yannoukakos, Drakoulis; Shen, Chen-Yang; Wu, Pei-Ei; Yu, Jyh-Cherng; Hou, Ming-Feng; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Jones, Michael; Pita, Guillermo; Alonso, M. Rosario; Álvarez, Nuria; Herrero, Daniel; Tessier, Daniel C.; Vincent, Daniel; Bacot, Francois; Luccarini, Craig; Baynes, Caroline; Ahmed, Shahana; Healey, Catherine S.; Brown, Melissa A.; Ponder, Bruce A.J.; Chenevix-Trench, Georgia; Thompson, Deborah J.; Edwards, Stacey L.; Easton, Douglas F.; Dunning, Alison M.; French, Juliet D.

    2015-01-01

    Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt to identify the biologically relevant variants, we analyzed 909 genetic variants across 5q11.2 in 103,991 breast cancer individuals and control individuals from 52 studies in the Breast Cancer Association Consortium. Multiple logistic regression analyses identified three independent risk signals: the strongest associations were with 15 correlated variants (iCHAV1), where the minor allele of the best candidate, rs62355902, associated with significantly increased risks of both estrogen-receptor-positive (ER+: odds ratio [OR] = 1.24, 95% confidence interval [CI] = 1.21–1.27, ptrend = 5.7 × 10−44) and estrogen-receptor-negative (ER−: OR = 1.10, 95% CI = 1.05–1.15, ptrend = 3.0 × 10−4) tumors. After adjustment for rs62355902, we found evidence of association of a further 173 variants (iCHAV2) containing three subsets with a range of effects (the strongest was rs113317823 [pcond = 1.61 × 10−5]) and five variants composing iCHAV3 (lead rs11949391; ER+: OR = 0.90, 95% CI = 0.87–0.93, pcond = 1.4 × 10−4). Twenty-six percent of the prioritized candidate variants coincided with four putative regulatory elements that interact with the MAP3K1 promoter through chromatin looping and affect MAP3K1 promoter activity. Functional analysis indicated that the cancer risk alleles of four candidates (rs74345699 and rs62355900 [iCHAV1], rs16886397 [iCHAV2a], and rs17432750 [iCHAV3]) increased MAP3K1 transcriptional activity. Chromatin immunoprecipitation analysis revealed diminished GATA3 binding to the minor (cancer-protective) allele of rs17432750, indicating a mechanism for its action. We propose that the cancer risk alleles act to increase MAP3K1 expression in vivo and might promote breast cancer cell survival. PMID:25529635

  8. Research of P2P SIP technology%P2P SIP技术的研究

    Institute of Scientific and Technical Information of China (English)

    隋晋光; 鲁士文

    2007-01-01

    在阐述P2P和SIP技术的基础上,引出了一种二者融合的新技术--P2P SIP,提出了采用P2P SIP技术系统的体系结构、工作方式,并且对P2P SIP技术的安全性问题进行了分析.

  9. Isotope shifts of the 2$p_{3/2}$-2$p_{1/2}$ transition in B-like ions

    CERN Document Server

    Zubova, N A; Tupitsyn, I I; Shabaev, V M; Kozhedub, Y S; Plunien, G; Brandau, C; Stohlker, Th

    2016-01-01

    Isotope shifts of the 2$p_{3/2}$-2$p_{1/2}$ transition in B-like ions are evaluated for a wide range of the nuclear charge number: Z=8-92. The calculations of the relativistic nuclear recoil and nuclear size effects are performed using a large scale configuration-interaction Dirac-Fock-Sturm method. The corresponding QED corrections are also taken into account. The results of the calculations are compared with the theoretical values obtained with other methods. The accuracy of the isotope shifts of the 2$p_{3/2}$-2$p_{1/2}$ transition in B-like ions is significantly improved.

  10. Isotope shifts of the 2 p3 /2-2 p1 /2 transition in B-like ions

    Science.gov (United States)

    Zubova, N. A.; Malyshev, A. V.; Tupitsyn, I. I.; Shabaev, V. M.; Kozhedub, Y. S.; Plunien, G.; Brandau, C.; Stöhlker, Th.

    2016-05-01

    Isotope shifts of the 2 p3 /2-2 p1 /2 transition in B-like ions are evaluated for a wide range of the nuclear charge number: Z =8 -92 . The calculations of the relativistic nuclear recoil and nuclear size effects are performed using a large-scale configuration-interaction Dirac-Fock-Sturm method. The corresponding QED corrections are also taken into account. The results of the calculations are compared with the theoretical values obtained with other methods. The accuracy of the isotope shifts of the 2 p3 /2-2 p1 /2 transition in B-like ions is significantly improved.

  11. AlvisP2P: Scalable Peer-to-Peer Text Retrieval in a Structured P2P Network

    OpenAIRE

    Luu, Toan; Skobeltsyn, Gleb; Klemm, Fabius; Puh, Maroje; Podnar Zarko, Ivana; Rajman, Martin; Aberer, Karl

    2008-01-01

    In this paper we present the AlvisP2P IR engine, which enables efficient retrieval with multi-keyword queries from a global document collection available in a P2P network. In such a network, each peer publishes its local index and invests a part of its local computing resources (storage, CPU, bandwidth) to maintain a fraction of a global P2P index. This investment is rewarded by the network-wide accessibility of the local documents via the global search facility. The AlvisP2P engine uses an o...

  12. First Detection of [C I] $^3$P$_1$-$^3$P$_0$ Emission from a Protoplanetary Disk

    CERN Document Server

    Tsukagoshi, Takashi; Saito, Masao; Kitamura, Yoshimi; Shimajiri, Yoshito; Kawabe, Ryohei

    2015-01-01

    We performed single point [C I] $^3$P$_1$-$^3$P$_0$ and CO J=4-3 observations toward three T Tauri stars, DM Tau, LkCa 15, and TW Hya, using the Atacama Large Millimeter/submillimeter Array (ALMA) Band 8 qualification model receiver installed on the Atacama Submillimeter Telescope Experiment (ASTE). Two protostars in the Taurus L1551 region, L1551 IRS 5 and HL Tau, were also observed. We successfully detected [C I] emission from the protoplanetary disk around DM Tau as well as the protostellar targets. The spectral profile of the [C I] emission from the protoplanetary disk is marginally single-peaked, suggesting that atomic carbon (C) extends toward the outermost disk. The detected [C I] emission is optically thin and the column densities of C are estimated to be <~10$^{16}$ cm$^{-2}$ and ~10$^{17}$ cm$^{-2}$ for the T Tauri star targets and the protostars, respectively. We found a clear difference in the total mass ratio of C to dust, $M$(C)/$M$(dust), between the T Tauri stars and protostellar targets; t...

  13. The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily

    Energy Technology Data Exchange (ETDEWEB)

    Fink, T.M.; Lichter, P. (Institut fuer angewandte Tumorvirologie, Heidelberg (Germany)); Wekerle, H.; Zimmer, M.; Jenne, D.E. (Max-Planck-Institut fuer Psychiatrie, Planegg-Martinsried (Germany))

    1993-11-01

    Human granzyme A (HFSP, Hanukah factor serine protease; CTLA3, cytotoxic T-lymphocyte-associated serine esterase-3), a homodimeric, trypsin-like serine protease of 60 kDa found in granules of cytolytic T cells and natural killer cells, is implicated in lymphocyte-mediated target cell lysis. It contributes to DNA fragmentation in perforin (PRF1)-lysed target cells through an unknown mechanism. The authors have isolated a cosmid clone for the functional gene of human granzyme A and established its complete exon-intron map of 10 kb. Using an 11-kb subfragment of the cloned genomic DNA as a probe, they have identified the chromosomal position of human granzyme A on 5q11-q12. Thus, the human granzyme A gene falls into a region of homology between human chromosome 5 and mouse chromosome 13, band D, where the mouse granzyme A gene has been located previously. The granzyme A gene is not linked to known members of the large superfamily of serine proteases. 20 refs., 2 figs.

  14. Queries mining for efficient routing in P2P communities

    CERN Document Server

    Ismail, Anis; Durand, Nicolas; Nachouki, Gilles; Hajjar, Mohammad

    2011-01-01

    Peer-to-peer (P2P) computing is currently attracting enormous attention. In P2P systems a very large number of autonomous computing nodes (the peers) pool together their resources and rely on each other for data and services. Peer-to-peer (P2P) Data-sharing systems now generate a significant portion of Internet traffic. Examples include P2P systems for network storage, web caching, searching and indexing of relevant documents and distributed network-threat analysis. Requirements for widely distributed information systems supporting virtual organizations have given rise to a new category of P2P systems called schema-based. In such systems each peer exposes its own schema and the main objective is the efficient search across the P2P network by processing each incoming query without overly consuming bandwidth. The usability of these systems depends on effective techniques to find and retrieve data; however, efficient and effective routing of content-based queries is a challenging problem in P2P networks. This wo...

  15. Comparing Pedophile Activity in Different P2P Systems

    OpenAIRE

    Raphaël Fournier; Thibault Cholez; Matthieu Latapy; Isabelle Chrisment; Clémence Magnien; Olivier Festor; Ivan Daniloff

    2014-01-01

    International audience Peer-to-peer (P2P) systems are widely used to exchange content over the Internet. Knowledge of pedophile activity in such networks remains limited, despite having important social consequences. Moreover, though there are different P2P systems in use, previous academic works on this topic focused on one system at a time and their results are not directly comparable. We design a methodology for comparing KAD and eDonkey, two P2P systems among the most prominent ones an...

  16. Code wars 10 years of P2P software litigation

    CERN Document Server

    Giblin, Rebecca

    2011-01-01

    Code Wars recounts the legal and technological history of the first decade of the P2P file sharing era, focusing on the innovative and anarchic ways in which P2P technologies evolved in response to decisions reached by courts with regard to their predecessors. With reference to US, UK, Canadian and Australian secondary liability regimes, this insightful book develops a compelling new theory to explain why a decade of ostensibly successful litigation failed to reduce the number, variety or availability of P2P file sharing applications - and highlights ways the law might need to change if it is

  17. Autoionization study of the Argon 2p satellites excited near the argon 2s threshold

    Energy Technology Data Exchange (ETDEWEB)

    Wang, H.; Glans, P.; Hemmers, O. [Univ. of Nevada, Las Vegas, NV (United States)] [and others

    1997-04-01

    The dynamics of near-threshold photoionization is a complex phenomenon in which the many-electron character of the wavefunctions plays an important role. According to generalized time-independent resonant scattering theory, the transition matrix element from an initial state to a final state is the summation of the amplitudes of direct photoionization and an indirect term in which intermediate states are involved and the resonant behavior is embedded. Studies of the interference effects of intermediate states have been explored in the cases where the direct term is negligible. In the present work, electron time-of-flight spectra of the Ar 2p satellites were measured at two angles (magic and 0{degrees}) in the dipole plane with the exciting photon energy tuned in the vicinity of the Ar 2s threshold. For excitation far below or above the 2s threshold, the 2p satellites spectrum is dominated by 3p to np shakeup contributions upon the ionization of a 2p electron.

  18. A Narrow and Highly Significant Linkage Signal for Severe Bipolar Disorder in the Chromosome 5q33 Region in Latin American Pedigrees

    Science.gov (United States)

    Jasinska, A.J.; Service, S.; Jawaheer, D.; DeYoung, J.; Levinson, M.; Zhang, Z.; Kremeyer, B.; Muller, H.; Aldana, I.; Garcia, J.; Restrepo, G.; Lopez, C.; Palacio, C.; Duque, C.; Parra, M.; Vega, J.; Ortiz, D.; Bedoya, G.; Mathews, C.; Davanzo, P.; Fournier, E.; Bejarano, J.; Ramirez, M.; Ortiz, C. Araya; Araya, X.; Molina, J.; Sabatti, C.; Reus, V.; Ospina, J.; Macaya, G.; Ruiz-Linares, A.; Freimer, N.B.

    2016-01-01

    We previously reported linkage of bipolar disorder to 5q33-q34 in families from two closely related population isolates, the Central Valley of Costa Rica (CVCR) and Antioquia, Colombia (CO). Here we present follow up results from fine-scale mapping in large CVCR and CO families segregating severe bipolar disorder, BP-I, and in 343 population trios/duos from CVCR and CO. Employing densely spaced SNPs to fine map the prior linkage peak region increases linkage evidence and clarifies the position of the putative BP-I locus. We performed two-point linkage analysis with 1134 SNPs in an approximately 9 Mb region between markers D5S410 and D5S422. Combining pedigrees from CVCR and CO yields a LOD score of 4.9 at SNP rs10035961. Two other SNPs (rs7721142 and rs1422795) within the same 94 kb region also displayed LOD scores greater than 4. This linkage peak coincides with our prior microsatellite results and suggests a narrowed BP-I susceptibility regions in these families. To investigate if the locus implicated in the familial form of BP-I also contributes to disease risk in the population, we followed up the family results with association analysis in duo and trio samples, obtaining signals within 2 Mb of the peak linkage signal in the pedigrees; rs12523547 and rs267015 (P = 0.00004 and 0.00016, respectively) in the CO sample and rs244960 in the CVCR sample and the combined sample, with P = 0.00032 and 0.00016, respectively. It remains unclear whether these association results reflect the same locus contributing to BP susceptibility within the extended pedigrees. PMID:19319892

  19. Chimpanzee chromosome 13 is homologous to human chromosome 2p

    Energy Technology Data Exchange (ETDEWEB)

    Sun, N. C.; Sun, C. R.Y.; Ho, T.

    1977-01-01

    Similarities between human and chimpanzee chromosomes are shown by chromosome banding techniques and somatic cell hybridization techniques. Cell hybrids were obtained from the chimpanzee lymphocyte LE-7, and the Chinese hamster mutant cell, Gal-2. Experiments showed that the ACPL, MDHs, and Gal-Act genes could be assigned to chimpanzee chromosome 13, and since these genes have been assigned to human chromosme 2p, it is suggested that chimpanzee chromosome 13 is homologous to human chromosome 2p. (HLW)

  20. P2P Concept Search: Some Preliminary Results

    OpenAIRE

    Giunchiglia, Fausto; Kharkevich, Uladzimir; Noori, S.R.H

    2009-01-01

    Concept Search extends syntactic search, i.e., search based on the computation of string similarity between words, with semantic search, i.e., search based on the computation of semantic relations between complex concepts. It allows us to deal with ambiguity of natural language. P2P Concept Search extends Concept Search by allowing distributed semantic search over structured P2P network. The key idea is to exploit distributed, rather than centralized, background knowledge and indices.

  1. Survey on Scheduling Technologies of P2P Media Streaming

    OpenAIRE

    Guangxue Yue; Nanqing Wei; Jiansheng Liu; Xiaofeng Xiong; Linquan Xie

    2011-01-01

    P2P streaming media applications grows rapidly. Scheduling technologies are the key of streaming research. After review the history of distribution systems. We studied the main data distribution topology and P2P streaming scheduling technologies. Compared current scheduling algorithms. Finally made a conclusion and forecasted scheduling in the mesh-tree distribution structure, heterogeous network, alone with security in scheduling will be the hotspots in the near future.

  2. Network Awareness in P2P-TV Applications

    Science.gov (United States)

    Traverso, Stefano; Leonardi, Emilio; Mellia, Marco; Meo, Michela

    The increasing popularity of applications for video-streaming based on P2P paradigm (P2P-TV) is raising the interest of both broadcasters and network operators. The former see a promising technology to reduce the cost of streaming content over the Internet, while offering a world-wide service. The latter instead fear that the traffic offered by these applications can grow without control, affecting other services, and possibly causing network congestion and collapse. The “Network-Aware P2P-TV Application over Wise Networks” FP7 project aims at studying and developing a novel P2P-TV application offering the chance to broadcast high definition video to broadcasters and to carefully manage the traffic offered by peers to the network, therefore avoiding worries to Internet providers about network overload. In such context, we design a simulator to evaluate performance of different P2P-TV solutions, to compare them both considering end-users’ and network providers’ perspectives, such as quality of service perceived by subscribers and link utilization. In this paper, we provide some results that show how effective can be a network aware P2P-TV system.

  3. Characterization of P2P IPTV Traffic: Scaling Analysis

    CERN Document Server

    Silverston, Thomas; Salamatian, Kave

    2007-01-01

    P2P IPTV applications arise on the Internet and will be massively used in the future. It is expected that P2P IPTV will contribute to increase the overall Internet traffic. In this context, it is important to measure the impact of P2P IPTV on the networks and to characterize this traffic. During the 2006 FIFA World Cup, we performed an extensive measurement campaign. We measured network traffic generated by broadcasting soccer games by the most popular P2P IPTV applications, namely PPLive, PPStream, SOPCast and TVAnts. From the collected data, we characterized the P2P IPTV traffic structure at different time scales. To the best of our knowledge, this is the first work, which presents a complete multiscale analysis of the P2P IPTV traffic. Our observations show that the network traffic has not the same scale behavior whether the applications use TCP or UDP. For all the applications, the download traffic is different from the upload traffic and the signaling traffic has an impact on the download traffic.

  4. P2P Data Management in Mobile Wireless Sensor Network

    Directory of Open Access Journals (Sweden)

    Nida Sahar Sayeda

    2013-04-01

    Full Text Available The rapid growth in wireless technologies has made wireless communication an important source for transporting data across different domains. In the same way, there are possibilities of many potential applications that can be deployed using WSNs (Wireless Sensor Networks. However, very limited applications are deployed in real life due to the uncertainty and dynamics of the environment and scare resources. This makes data management in WSN a challenging area to find an approach that suits its characteristics. Currently, the trend is to find efficient data management schemes using evolving technologies, i.e. P2P (Peer-to-Peer systems. Many P2P approaches have been applied in WSNs to carry out the data management due to similarities between WSN and P2P. With the similarities, there are differences too that makes P2P protocols inefficient in WSNs. Furthermore, to increase the efficiency and to exploit the delay tolerant nature of WSNs, where ever possible, the mobile WSNs are gaining importance. Thus, creating a three dimensional problem space to consider, i.e. mobility, WSNs and P2P. In this paper, an efficient algorithm is proposed for data management using P2P techniques for mobile WSNs. The real world implementation and deployment of proposed algorithm is also presented

  5. Improving P2P live-content delivery using SVC

    Science.gov (United States)

    Schierl, T.; Sánchez, Y.; Hellge, C.; Wiegand, T.

    2010-07-01

    P2P content delivery techniques for video transmission have become of high interest in the last years. With the involvement of client into the delivery process, P2P approaches can significantly reduce the load and cost on servers, especially for popular services. However, previous studies have already pointed out the unreliability of P2P-based live streaming approaches due to peer churn, where peers may ungracefully leave the P2P infrastructure, typically an overlay networks. Peers ungracefully leaving the system cause connection losses in the overlay, which require repair operations. During such repair operations, which typically take a few roundtrip times, no data is received from the lost connection. While taking low delay for fast-channel tune-in into account as a key feature for broadcast-like streaming applications, the P2P live streaming approach can only rely on a certain media pre-buffer during such repair operations. In this paper, multi-tree based Application Layer Multicast as a P2P overlay technique for live streaming is considered. The use of Flow Forwarding (FF), a.k.a. Retransmission, or Forward Error Correction (FEC) in combination with Scalable video Coding (SVC) for concealment during overlay repair operations is shown. Furthermore the benefits of using SVC over the use of AVC single layer transmission are presented.

  6. Systematic screening at diagnosis of -5/del(5)(q31), -7, or chromosome 8 aneuploidy by interphase fluorescence in situ hybridization in 110 acute myelocytic leukemia and high-risk myelodysplastic syndrome patients: concordances and discrepancies with conventional cytogenetics.

    NARCIS (Netherlands)

    Beyer, V.; Castagne, C.; Muhlematter, D.; Parlier, V.; Gmur, J.; Hess, U.; Kovacsovics, T.; Meyer-Monard, S.; Tichelli, A.; Tobler, A.; Jacky, E.; Schanz, U.; Bargetzi, M.; Hagemeijer, A.; Witte, T.J.M. de; Melle, G. van; Jotterand-Bellomo, M.

    2004-01-01

    To assess the contribution of interphase fluorescence in situ hybridization (I-FISH) toward the detection of recurring unbalanced chromosomal anomalies at diagnosis, a systematic screening of -5/del(5)(q31), -7, and chromosome 8 aneuploidy was performed on 110 patients with acute myelocytic leukemia

  7. Electron impact excitation out of the metastable levels of argon into the 3p{sup 5}4p J = 3 level

    Energy Technology Data Exchange (ETDEWEB)

    Boffard, J.B.; Piech, G.A.; Gehrke, M.F.; Lagus, M.E.; Anderson, L.W.; Lin, C.C. [Wisconsin Univ., Madison, WI (United States). Dept. of Physics

    1996-11-28

    We have measured the direct cross section for electron impact excitation out of the metastable 3p{sup 5}4s[3/2]{sub 2}{sup 0} level (1s{sub 5} in Paschen`s notation) into the 3p{sup 5}4p[5/2]{sub 3} level (2p{sub 9}) of argon from threshold to 800 eV. The direct cross section is 40 x 10{sup -16} cm{sup 2} at 10 eV. (author).

  8. Theatrical distribution and P2P movie piracy: a survey of P2P networks in Hungary using transactional data

    OpenAIRE

    Bodó, B.; Lakatos, Z.

    2012-01-01

    This article examines what appears to be the most important factor shaping file sharing: the failure of traditional cultural markets to efficiently supply the demand in the online environment. Its findings are based on tracking the traffic of movies on three Hungarian P2P networks. This dataset is then matched with cinematic distribution data of the films tracked in P2P transactions. Central to our analysis is the assessment of two piracy paradigms: substitution and shortage, that is, whether...

  9. P2P Simulator for Queries Routing Using Data Mining

    Directory of Open Access Journals (Sweden)

    Anis ISMAIL

    2011-09-01

    Full Text Available Data mining is used to extract hidden information from large databases. In Peer-to-Peer context, achallenging problem is how to find the appropriate Peer to deal with a given query without overlyconsuming bandwidth. Different methods proposed routing strategies of queries taking into account theP2P network at hand. An unstructured P2P system based on an organization of Peers around Super-Peersthat are connected to Super-Super-Peer according to their semantic domains is considered. This paperintegrates Decision Trees in P2P architectures for predicting Query-Suitable Super-Peers representing acommunity of Peers, where one among them is able to answer the given query. In fact, by analyzing thequeries’ log file, a predictive model that avoids flooding queries in the P2P networks constructed bypredicting the appropriate Super-Peer, and hence the Peer to answer the query. The proposed architectureis based on a Decision Tree (Base-Knowledge - BK. The efficiency of these architectures is discussedconsidering architecture without knowledge (Baseline using only the flooding queries method to answerqueries. The advantage of this knowledge based model is the robustness in Queries routing mechanism andscalability in P2P Network.

  10. A Framework For Concept Drifting P2P Traffic Identification

    Directory of Open Access Journals (Sweden)

    Guanghui Yan

    2013-08-01

    Full Text Available Identification of network traffic using port-based or payload-based analysis is becoming increasing difficult with many Peer-to-Peer (P2P application using dynamic ports, masquerading techniques, and encryption to avoid detection. To overcome this problem, several machine learning technique were proposed to classify P2P traffics. But in the real P2P network environment, new communities of peers often attend and old communities of peers often leave. It requires the identification methods to be capable of coping with concept drift, and updating the model incrementally. In this paper, we present a concept-adapting algorithm CluMC which is based on streaming data mining techniques to identify P2P applications in Internet traffic. The CluMC use micro-cluster structures which contain potential micro-cluster structures and outlier micro-cluster structures to classify the P2P traffic and discover the concept drift with limited memory. Our performance study over a number of real data sets that we captured at a main gateway router demonstrates the effectiveness and efficiency of our method.

  11. Behavioural Correlation for Detecting P2P Bots

    CERN Document Server

    Al-Hammadi, Yousof

    2010-01-01

    In the past few years, IRC bots, malicious programs which are remotely controlled by the attacker through IRC servers, have become a major threat to the Internet and users. These bots can be used in different malicious ways such as issuing distributed denial of services attacks to shutdown other networks and services, keystrokes logging, spamming, traffic sniffing cause serious disruption on networks and users. New bots use peer to peer (P2P) protocols start to appear as the upcoming threat to Internet security due to the fact that P2P bots do not have a centralized point to shutdown or traceback, thus making the detection of P2P bots is a real challenge. In response to these threats, we present an algorithm to detect an individual P2P bot running on a system by correlating its activities. Our evaluation shows that correlating different activities generated by P2P bots within a specified time period can detect these kind of bots.

  12. Measurement of the spin-forbidden decay rate (3s3d)1D2¿(3s3p)3 P2,1 in 24Mg

    DEFF Research Database (Denmark)

    Therkildsen, K. T.; Jensen, Brian Bak; Ryder, C. P.;

    2009-01-01

    We have measured the spin-forbidden decay rate from (3s3d)D12¿(3s3p)P32,1 in M24g atoms trapped in a magneto-optical trap. The total decay rate, summing up both exit channels (3s3p)P31 and (3s3p)P32 , yields 196±10s-1 in excellent agreement with resent relativistic many-body calculations of Porsev...

  13. Four novel Loci (19q13, 6q24, 12q24, and 5q14 influence the microcirculation in vivo.

    Directory of Open Access Journals (Sweden)

    M Kamran Ikram

    2010-10-01

    Full Text Available There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery cohorts with 15,358 unrelated Caucasian individuals, who are members of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE consortium, and replicated findings in four independent Caucasian cohorts (n  =  6,652. All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software. In the discovery cohorts, 179 single nucleotide polymorphisms (SNP spread across five loci were significantly associated (p<5.0×10(-8 with retinal venular caliber, but none showed association with arteriolar caliber. Collectively, these five loci explain 1.0%-3.2% of the variation in retinal venular caliber. Four out of these five loci were confirmed in independent replication samples. In the combined analyses, the top SNPs at each locus were: rs2287921 (19q13; p  =  1.61×10(-25, within the RASIP1 locus, rs225717 (6q24; p = 1.25×10(-16, adjacent to the VTA1 and NMBR loci, rs10774625 (12q24; p  =  2.15×10(-13, in the region of ATXN2,SH2B3 and PTPN11 loci, and rs17421627 (5q14; p = 7.32×10(-16, adjacent to the MEF2C locus. In two independent samples, locus 12q24 was also associated with coronary heart disease and hypertension. Our population-based genome-wide association study demonstrates four novel loci associated with retinal venular caliber, an endophenotype of the microcirculation associated with clinical cardiovascular disease. These data provide further insights into the contribution and biological mechanisms of microcirculatory changes that underlie cardiovascular

  14. Model of Controlling the Hubs in P2P Networks

    Directory of Open Access Journals (Sweden)

    Yuhua Liu

    2009-06-01

    Full Text Available Research into the hubs in Peer-to-Peer (P2P networks, and present a new method to avoid generating the hubs in the networks by controlling the logical topology structure of P2P networks. We firstly introduce the controlling ideas about hierarchizing the hubs. Then, we disclose and interpret the controlling model, and give out the concrete method to carry it out. Finally, we validate our controlling model via simulations and the simulation results demonstrate that our work is effective to control the hubs in P2P networks. Thus, this model can improve the network competence to defend against coordinated attacks, promote the network robustness, and ensure the network would develop continually and healthily.

  15. On Using Seeders for P2P Live Streaming

    CERN Document Server

    Mathieu, Fabien

    2011-01-01

    Seeders (peers that do not request anything but contribute to the system) are a powerful concept in peer-to-peer (P2P). They allow to leverage the capacities of a P2P system. While seeding is a natural idea for filesharing or video-on-demand applications, it seems somehow counter-intuitive in the context of live streaming. This paper aims at describing the feasibility and performance of P2P live seeding. After a formal definition of "live seeding" and efficiency, we consider the theoretical performance of systems where the overhead is neglected. We then propose a linear overhead model and extend the results for this model, for a single seeder and for a set of seeders as well (it is not always possible to perfectly aggregate individual efficiencies in a given system).

  16. Compromising Tor Anonymity Exploiting P2P Information Leakage

    CERN Document Server

    Manils, Pere; Blond, Stevens Le; Kaafar, Mohamed Ali; Castelluccia, Claude; Legout, Arnaud; Dabbous, Walid

    2010-01-01

    Privacy of users in P2P networks goes far beyond their current usage and is a fundamental requirement to the adoption of P2P protocols for legal usage. In a climate of cold war between these users and anti-piracy groups, more and more users are moving to anonymizing networks in an attempt to hide their identity. However, when not designed to protect users information, a P2P protocol would leak information that may compromise the identity of its users. In this paper, we first present three attacks targeting BitTorrent users on top of Tor that reveal their real IP addresses. In a second step, we analyze the Tor usage by BitTorrent users and compare it to its usage outside of Tor. Finally, we depict the risks induced by this de-anonymization and show that users' privacy violation goes beyond BitTorrent traffic and contaminates other protocols such as HTTP.

  17. Trust Model Based on P2P Network

    Directory of Open Access Journals (Sweden)

    Guang Ouyang

    2013-09-01

    Full Text Available In order to change the defect of traditional trust model, the research on trust model based on P2P network is proposed in this paper. It is based on the theoretical characteristic of P2P network and analyzes the trust mechanism and application model and set up a kind of new trust model. This kind of trust model is great helpful to improve the success rate of transaction and the trust model was designed. Finally, the simulation experiment is made. The results show that using P2P trust model can be more effectively inhibit and isolate the malicious nodes than the other and improving PZP network environment can make the network gets a benign development.

  18. N(2P) in the dayglow - Measurement and theory

    Science.gov (United States)

    Torr, Marsha R.; Torr, Douglas G.; Richards, P. G.

    1993-01-01

    During the ATLAS-1 mission, the first dayglow altitude profiles were obtained of the N(2P) emission at 3466 A. These observations were made in the sunlit thermosphere using the Imaging Spectrometric Observatory. As all previous work on this emission has been done under auroral conditions, this study represents the first examination of the photochemical sources and sinks of N(2P) in the normal daytime thermospheric, with comparison with measurements. We find that the observations are explained by a model in which the major source is photodissociation of N2, and quenching by O is the principal low-altitude loss process, with radiative decay to N(2D) dominating above 200 km. As the dominant loss processes are likely to result in the production of N(2D), N(2P) could be a moderate source of N(2D) and may be a factor to be taken into consideration in modeling NO.

  19. P2P STREAMING MEDIA INDUSTRY IN CHINA

    OpenAIRE

    Dai, Steffi (Wenjing)

    2009-01-01

    The peer-to-peer (P2P) streaming media industry opened up a new era for the cyber age, has had a significant effect on many people?s leisure time, and has changed the way many people use entertainment. Over the past few years, this industry has developed dramatically in China, and it is thriving. In terms of the current situation, the P2P streaming media industry holds typical Chinese features that both enrich the audience?s cultural life, and have some impact on other kinds of mass media. Th...

  20. High-resolution absolute photoabsorption cross sections for Ne in the 1s2s and 1s2p resonant double excitation

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Masahiro [National Institute of Advanced Industrial Science and Technology (AIST), NMIJ, Tsukuba, Ibaraki 305-8568 (Japan); Morishita, Yuichiro [National Institute of Advanced Industrial Science and Technology (AIST), NMIJ, Tsukuba, Ibaraki 305-8568 (Japan); Koike, Fumihiro [School of Medicine, Kitasato University, Kitasato, Sagamihara 228-8555 (Japan); Fritzsche, Stephan [Physics Department, Kassel University, Heinrich-Plett-strasse 40, D-34132 Kassel (Germany); Yamaoka, Hitoshi [RIKEN, Harima Institute, Sayo, Hyogo 679-5148 (Japan); Tamenori, Yusuke [Japan Synchrotron Radiation Research Institute, Sayo, Hyogo 679-5198, Japan (Japan); Okada, Kazumasa [Department of Chemistry, Hiroshima University, Higashi-Hiroshima 739-8526 (Japan); Matsudo, Takahisa [Department of Chemistry, Hiroshima University, Higashi-Hiroshima 739-8526 (Japan); Gejo, Tatsuo [University of Hyogo, Kamigori, Hyogo 678-1297 (Japan); Suzuki, Isao H [National Institute of Advanced Industrial Science and Technology (AIST), NMIJ, Tsukuba, Ibaraki 305-8568 (Japan); Saito, Norio [National Institute of Advanced Industrial Science and Technology (AIST), NMIJ, Tsukuba, Ibaraki 305-8568 (Japan)

    2006-04-28

    The high-resolution absolute photoabsorption cross sections with an absolute photon energy scale for Ne 1s2p/1s2s double excitation in the energy region of 900-940 eV have been measured using a multi-electrode ionization chamber and monochromatized synchrotron radiation. The Ne [1s2p]({sup 3,1}P)nln'l' doubly excited states observed in the energy range of 900-920 eV are analysed with the aid of theoretical calculations based on the multiconfiguration Dirac-Fock method. The second strongest peak in this energy region is assigned to be [1s2p]({sup 3}P)3p4p.

  1. Silane photoabsorption spectra near the Si 2p thresholds: the geometry of Si 2p excited SiH4

    Institute of Scientific and Technical Information of China (English)

    张卫华; 许如清; 李家明

    2003-01-01

    Based on the multiple-scattering self-consistent-field method, we have studied the photoabsorption spectra near the Si 2p thresholds of silane. According to our calculations, the clear assignments of the inner-shell photoabsorption spectra are provided. In comparison with the high-resolution experimental spectra, the geometric structure of the Si 2p-excited SiH4** is recommended to be of a C2v symmetry. More specifically, the Si 2p-excited Si4** have two bond lengths of 2.50 a.u. and another two bond lengths of 2.77 a.u., and the corresponding two bond angles are 104.0° and 112.5° respectively.

  2. P2P Domain Classification using Decision Tree

    CERN Document Server

    Ismail, Anis

    2011-01-01

    In Peer-to-Peer context, a challenging problem is how to find the appropriate peer to deal with a given query without overly consuming bandwidth? Different methods proposed routing strategies of queries taking into account the P2P network at hand. This paper considers an unstructured P2P system based on an organization of peers around Super-Peers that are connected to Super-Super- Peer according to their semantic domains; By analyzing the queries log file, a predictive model that avoids flooding queries in the P2P network is constructed after predicting the appropriate Super-Peer, and hence the peer to answer the query. A challenging problem in a schema-based Peer-to-Peer (P2P) system is how to locate peers that are relevant to a given query. In this paper, architecture, based on (Super-)Peers is proposed, focusing on query routing. The approach to be implemented, groups together (Super-)Peers that have similar interests for an efficient query routing method. In such groups, called Super-Super-Peers (SSP), Su...

  3. Comparing Pedophile Activity in Different P2P Systems

    Directory of Open Access Journals (Sweden)

    Raphaël Fournier

    2014-07-01

    Full Text Available Peer-to-peer (P2P systems are widely used to exchange content over the Internet. Knowledge of pedophile activity in such networks remains limited, despite having important social consequences. Moreover, though there are different P2P systems in use, previous academic works on this topic focused on one system at a time and their results are not directly comparable. We design a methodology for comparing KAD and eDonkey, two P2P systems among the most prominent ones and with different anonymity levels. We monitor two eDonkey servers and the KAD network during several days and record hundreds of thousands of keyword-based queries. We detect pedophile-related queries with a previously validated tool and we propose, for the first time, a large-scale comparison of pedophile activity in two different P2P systems. We conclude that there are significantly fewer pedophile queries in KAD than in eDonkey (approximately 0.09% vs. 0.25%.

  4. Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15. 3-11p15. 1 by fluorescence in situ hybridization

    Energy Technology Data Exchange (ETDEWEB)

    Taviaux, S.A.; Demaille, J.G. (CRBM-CNRS and U 249 INSERM, Montpellier (France))

    1993-01-01

    The cell cycle control genes are highly conserved during evolution since they play a key role in the regulation of cell division. We have localized CDC25C and WEE1 respectively at 5q31 and 11p15.3-11p15.1 using fluorescent in situ hybridization of cDNA probes on human chromosomes. This shows that genes acting through a regulatory phosphorylation cascade are not clustered on the same chromosome. Furthermore, they appear to map on chromosomal regions involved in tumorigenesis. The 5q23-q31 region of chromosome 5 is deleted in some hematologic disorders, and the p15 region of chromosome 11 is involved in development of embryonic tumors. 26 refs., 1 fig.

  5. Theatrical distribution and P2P movie piracy: a survey of P2P networks in Hungary using transactional data

    NARCIS (Netherlands)

    B. Bodó; Z. Lakatos

    2012-01-01

    This article examines what appears to be the most important factor shaping file sharing: the failure of traditional cultural markets to efficiently supply the demand in the online environment. Its findings are based on tracking the traffic of movies on three Hungarian P2P networks. This dataset is t

  6. A new PC(sp(3))P ligand and its coordination chemistry with low-valent iron, cobalt and nickel complexes.

    Science.gov (United States)

    Zhu, Gengyu; Li, Xiaoyan; Xu, Guoqiang; Wang, Lin; Sun, Hongjian

    2014-06-21

    A new PC(sp(3))P ligand N,N'-bis(diphenylphosphino)dipyrromethane [PCH2P] (1) was prepared and its iron, cobalt and nickel chemistry was explored. Two pincer-type complexes [PCHP]Fe(H)(PMe3)2 (2) and [PCHP]Co(PMe3)2 (4) were synthesized in the reaction of with Fe(PMe3)4 and Co(Me)(PMe3)4. 1 reacted with Co(PMe3)4 and Ni(PMe3)4 to afford Co(0) and Ni(0) complexes [PCH2P]Co(PMe3)2 (3) and [PCH2P]Ni(PMe3)2 (5). The structures of complexes 2-5 were determined by X-ray diffraction.

  7. Syntenic homology of human unique DNA sequences within chromossome regions 5q31, 10q22, 13q32-33 and 19q13.1 in the great apes

    Directory of Open Access Journals (Sweden)

    Vallente-Samonte Rhea U.

    2000-01-01

    Full Text Available Homologies between chromosome banding patterns and DNA sequences in the great apes and humans suggest an apparent common origin for these two lineages. The availability of DNA probes for specific regions of human chromosomes (5q31, 10q22, 13q32-33 and 19q13.1 led us to cross-hybridize these to chimpanzee (Pan troglodytes, PTR, gorilla (Gorilla gorilla, GGO and orangutan (Pongo pygmaeus, PPY chromosomes in a search for equivalent regions in the great apes. Positive hybridization signals to the chromosome 5q31-specific DNA probe were observed at HSA 5q31, PTR 4q31, GGO 4q31 and PPY 4q31, while fluorescent signals using the chromosome 10q22-specific DNA probe were noted at HSA 10q22, PTR 8q22, GGO 8q22 and PPY 7q22. The chromosome arms showing hybridization signals to the Quint-EssentialTM 13-specific DNA probe were identified as HSA 13q32-33, PTR 14q32-33, GGO 14q32-33 and PPY 14q32-33, while those presenting hybridization signals to the chromosome 19q13.1-specific DNA probe were identified as HSA 19q13.1, PTR 20q13, GGO 20q13 and PPY 20q13. All four probes presumably hybridized to homologous chromosomal locations in the apes, which suggests a homology of certain unique DNA sequences among hominoid species.

  8. Mobile P2P Trusted On-Demand Video Streaming

    CERN Document Server

    Iyer, Thava; Rizvandi, Nikzad Babaii; Varghese, Benoy; Boreli, Roksana

    2012-01-01

    We propose to demonstrate a mobile server assisted P2P system for on-demand video streaming. Our proposed solution uses a combination of 3G and ad-hoc Wi-Fi connections, to enable mobile devices to download content from a centralised server in a way that minimises the 3G bandwidth use and cost. On the customised GUI, we show the corresponding reduction in 3G bandwidth achieved by increasing the number of participating mobile devices in the combined P2P and ad-hoc Wi- Fi network, while demonstrating the good video playout quality on each of the mobiles. We also demonstrate the implemented trust mechanism which enables mobiles to only use trusted adhoc connections. The system has been implemented on Android based smartphones.

  9. MSPnet: MANAGEABLE SIP P2P MEDIA DISTRIBUTION SYSTEM

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The letter proposes a three-layer manageable media distribution network system architecture called MSPnet, which is based on Session Initiation Protocol[1] and Peer to Peer (SIP P2P)technology. MSPnet performs application-level structured DHT routing and resource location among domains and unstructured ones in domain. Except for media distribution, it can be used to support a variety of P2P applications, including video broadcasting, video on demand, VoIP, etc. MSPnet is composed of three layers, namely, the signal control layer, the management layer, and the media transportation layer. The MSPnet prototype consists of the SIP server, the management server, the media server, and the node User Agent (UA). Results from a prototype experiment in a large-scale Internet environment show that MSPnet is feasible, scalable and manageable.

  10. Addressing the P2P Bootstrap Problem for Small Networks

    CERN Document Server

    Wolinsky, David Isaac; Boykin, P Oscar; Figueiredo, Renato

    2010-01-01

    P2P overlays provide a framework for building distributed applications consisting of few to many resources with features including self-configuration, scalability, and resilience to node failures. Such systems have been successfully adopted in large-scale services for content delivery networks, file sharing, and data storage. In small-scale systems, they can be useful to address privacy concerns and for network applications that lack dedicated servers. The bootstrap problem, finding an existing peer in the overlay, remains a challenge to enabling these services for small-scale P2P systems. In large networks, the solution to the bootstrap problem has been the use of dedicated services, though creating and maintaining these systems requires expertise and resources, which constrain their usefulness and make them unappealing for small-scale systems. This paper surveys and summarizes requirements that allow peers potentially constrained by network connectivity to bootstrap small-scale overlays through the use of e...

  11. Behavioural Correlation for Detecting P2P Bots

    OpenAIRE

    Al-Hammadi, Yousof; Aickelin, Uwe

    2010-01-01

    In the past few years, IRC bots, malicious programs which are remotely controlled by the attacker through IRC servers, have become a major threat to the Internet and users. These bots can be used in different malicious ways such as issuing distributed denial of services attacks to shutdown other networks and services, keystrokes logging, spamming, traffic sniffing cause serious disruption on networks and users. New bots use peer to peer (P2P) protocols start to appear ...

  12. Addressing the P2P Bootstrap Problem for Small Networks

    OpenAIRE

    Wolinsky, David Isaac; Juste, Pierre St.; Boykin, P. Oscar; Figueiredo, Renato

    2010-01-01

    P2P overlays provide a framework for building distributed applications consisting of few to many resources with features including self-configuration, scalability, and resilience to node failures. Such systems have been successfully adopted in large-scale services for content delivery networks, file sharing, and data storage. In small-scale systems, they can be useful to address privacy concerns and for network applications that lack dedicated servers. The bootstrap problem, finding an existi...

  13. An Efficient Secure Multicast Communication for P2P Network

    Directory of Open Access Journals (Sweden)

    Huaiqing Lin

    2011-03-01

    Full Text Available A new algorithm for efficient key management for secure group communication in P2P network is presented. The protocol avoids the escrow problem in identity-based cryptosystem and the secure delivery of private keys. It has two rounds and requires constant pairing operation per user. The security of protocol is based on some underlying problems closely related to the Bilinear Diffie-Hellman Problem are computationally hard.  

  14. On Reducing Delays in P2P Live Streaming Systems

    OpenAIRE

    Huang, Fei

    2010-01-01

    In the recent decade, peer-to-peer (P2P) technology has greatly enhanced the scalability of multimedia streaming on the Internet by enabling efficient cooperation among end-users. However, existing streaming applications are plagued by the problems of long playback latency and long churn-induced delays. First of all, many streaming applications, such as IPTV and video conferencing, have rigorous constraints on end-to-end delays. Moreover, churn-induced delays, including delays from channel sw...

  15. A P2P streaming service architecture with distributed caching

    Institute of Scientific and Technical Information of China (English)

    GUO Pan-hong; YANG Yang; LI Xin-you

    2007-01-01

    Multimedia streaming served through peer-to-peer (P2P) networks is booming nowadays. However, the end-to-end streaming quality is generally unstable due to the variability of the state of serve-peers. On the other hand, proxy caching is a bandwidth-efficient scheme for streaming over the Internet, whereas it is a substantially expensive method needing dedicated powerful proxy servers. In this paper, we present a P2P cooperative streaming architecture combined with the advantages of both P2P networks and multimedia proxy caching techniques to improve the streaming quality of participating clients. In this framework, a client will simultaneously retrieve contents from the server and other peers that have viewed and cached the same title before. In the meantime, the client will also selectively cache the aggregated video content so as to serve still future clients. The associate protocol to facilitate the multi-path streaming and a distributed utility-based partial caching scheme are detailedly discussed. We demonstrate the effectiveness of this proposed architecture through extensive simulation experiments on large, Internet-like topologies.

  16. Relativistic calculations of 3s21S0-3s3p 1P1 and 3s21S0-3s3p 3P1,2 transition probabilities in the Mg isoelectronic sequence

    International Nuclear Information System (INIS)

    Using the multi-configuration Dirac—Fock self-consistent field method and the relativistic configuration-interaction method, calculations of transition energies, oscillator strengths and rates are performed for the 3s21S0-3s3p 1P1 spin-allowed transition, 3s21S0-3s3p 3P1,2 intercombination and magnetic quadrupole transition in the Mg isoelectronic sequence (Mg I, Al II, Si III, P IV and S V). Electron correlations are treated adequately, including intravalence electron correlations. The influence of the Breit interaction on oscillator strengths and transition energies are investigated. Quantum electrodynamics corrections are added as corrections. The calculation results are found to be in good agreement with the experimental data and other theoretical calculations. (atomic and molecular physics)

  17. Gestor de almacenamiento en redes P2P

    OpenAIRE

    Olías de Lima Pancorbo, Carlos

    2009-01-01

    El objetivo del proyecto consiste en la implementación de un sistema de archivos distribuido mediante P2P, basándose en el entorno de desarrollo .NET. Para dicho desarrollo, la primera parte del proyecto consiste en la familiarización con un nuevo lenguaje de desarrollo integrado en la plataforma Visual Studio: Visual Basic.NET. En segundo lugar, una vez adquiridos los conocimientos necesarios para el desarrollo de aplicaciones en dicha plataforma, se implementará un Sistema de Archivos Distr...

  18. Efficient Search in P2P File Sharing System

    Institute of Scientific and Technical Information of China (English)

    Xiao Bo; Jin Wei; Hou Mengshu

    2006-01-01

    A new routing algorithm of peer-to-peer file sharing system with routing indices was proposed, in which a node forwards a query to neighbors that are more likely to have answers based on its statistics. The proposed algorithm was tested by creating a P2P simulator and varying the input parameters, and was compared to the search algorithms using flooding (FLD) and random walk (RW). The result shows that with the proposed design, the queries are routed effectively, the network flows are reduced remarkably, and the peer-to-peer file sharing system gains a good expansibility.

  19. Hermes, a collaborative environment at IN2P3

    Energy Technology Data Exchange (ETDEWEB)

    Helft, Christian, E-mail: helft@lal.in2p3.f [Laboratoire de l' Accelerateur Lineaire Bat 200 91898 ORSAY Cedex (France)

    2010-04-01

    IN2P3, the institute bringing together HEP laboratories in France, opened a videoconferencing service in 2002 based on an industry standard H323 MCU (Multiple Control Unit). This service has steadily grown since then, serving other French scientific communities in addition to HEP and reaching an average of about thirty conferences a day. The relatively small amount of manpower required to deploy and maintain this facility can be explained by the very sound design and the large array of built-in capabilities offered by the equipment that replaced the original equipment purchased in 2005.

  20. Random walk search in unstructured P2P

    Institute of Scientific and Technical Information of China (English)

    Jia Zhaoqing; You Jinyuan; Rao Ruonan; Li Minglu

    2006-01-01

    Unstructured P2P has power-law link distribution, and the random walk in power-law networks is analyzed. The analysis results show that the probability that a random walker walks through the high degree nodes is high in the power-law network, and the information on the high degree nodes can be easily found through random walk. Random walk spread and random walk search method (RWSS) is proposed based on the analysis result. Simulation results show that RWSS achieves high success rates at low cost and is robust to high degree node failure.

  1. KⅧ-TbLⅣ离子3s3p 3P1-3s2 1S0 的自旋禁戒跃迁%Intercombination Transitions 3s3p 3P1-3s2 1S0 in Magnesium-like Ions through KⅧ to TbLⅣ

    Institute of Scientific and Technical Information of China (English)

    牟致栋; 魏琦瑛

    2004-01-01

    在对KⅧ-TbLⅣ离子3s3p 3P1能级结构的多组态相互作用理论HXR方法计算的基础上, 分析了各种效应对等电子序列离子能级结构的影响, 找出了能级沿等电子序列变化的规律性. 预测计算了K Ⅷ-Tb LⅣ离子3s3p 3P1的能级. 由此进一步计算了KⅧ-TbL Ⅳ离子自旋禁戒跃迁3s3p 3P1-3s2 1S0的谱线波长、振子强度和跃迁概率.

  2. The RP-Mdm2-p53 Pathway and Tumorigenesis

    Science.gov (United States)

    Miliani de Marval, Paula L.; Zhang, Yanping

    2011-01-01

    The dynamic processes of cell growth and division are under constant surveillance. As one of the primary “gatekeepers” of the cell, the p53 tumor suppressor plays a major role in sensing and responding to a variety of stressors to maintain cellular homeostasis. Recent studies have shown that inhibition of ribosomal biogenesis can activate p53 through ribosomal protein (RP)-mediated suppression of Mdm2 E3 ligase activity. Mutations in Mdm2 that disrupt RP binding have been detected in human cancers; however, the physiological significance of the RP-Mdm2 interaction is not completely understood. We generated mice carrying a single cysteine-to-phenylalanine substitution in the central zinc finger of Mdm2 (Mdm2C305F) that disrupts Mdm2’s binding to RPL11 and RPL5. Despite being developmentally normal and maintaining an intact p53 response to DNA damage, the Mdm2C305F mice demonstrate a diminished p53 response to perturbations in ribosomal biogenesis, providing the first in vivo evidence for an RP-Mdm2-p53 signaling pathway. Here we review some recent studies about RP-Mdm2-p53 signaling and speculate on the relevance of this pathway to human cancer. PMID:21406728

  3. Content Distribution Mechanism in Mobile P2P Network

    Directory of Open Access Journals (Sweden)

    Degui Zeng

    2014-05-01

    Full Text Available As content distribution in mobile P2P network facing architecture instability, the limited ability of a single node, low efficiency of content distribution and other problems, this paper proposes a new mobile network structure and content distribution mechanism strategy, the new mobile network structure will be divided into multiple subnets network for partition management. Each subnet manages information routing and dissemination strategies through a super-node. The transfer of information between subnets can be achieved by transitional node in cross region. Thus the information transfer is achieved in the entire network. Content distribution strategies using part of network coding mechanism for data compression, improve the efficiency of information transmission and download success rate. Finally, experimental verification, the experimental results show that: the proposed new mobile network structure and content distribution mechanisms strategies can reduce the disturbance of download success rate caused by fixed point, reduce the data transmission delay, and effectively improve the hit rate

  4. Medium Effects in Cooling of Neutron Stars and $3P_2$ Neutron Gap

    OpenAIRE

    Grigorian, H.; Voskresensky, D.N.(National Research Nuclear University (MEPhI), Moscow, 115409, Russia)

    2005-01-01

    We study the dependence of the cooling of isolated neutron stars on the magnitude of the $3P_2$ neutron gap. It is demonstrated that our ``nuclear medium cooling'' scenario is in favor of a suppressed value of the $3P_2$ neutron gap.

  5. Sizeable beta-strength in 31Ar (beta 3p) decay

    DEFF Research Database (Denmark)

    T. Koldste, G.; Blank, B.; J. G. Borge, M.;

    2014-01-01

    We present for the first time precise spectroscopic information on the recently discovered decay mode beta-delayed 3p-emission. The detection of the 3p events gives an increased sensitivity to the high energy part of the Gamow-Teller strength distribution from the decay of 31Ar revealing that as ...

  6. The direct measurement of the 3 3P0-3 3P1 fine-structure interval and the gJ-factor of atomic silicon by laser magnetic resonance

    Science.gov (United States)

    Evenson, K. M.; Beltran-Lopez, V.; Ley-Koo, E.; Inguscio, M.

    1984-01-01

    The J - 1 fine structure interval and the g-factor of the 3P1 state have been determined with high precision in the present laser magnetic resonance measurements of the ground 3p2 3P multiplet of atomic Si. Delta-E(3P1-3P0) = 2,311,755.6(7) MHz, and gJ(3P1) = 1.500830(70). Single-configuration calculations of gJ for 3P1 and 3P2 yield a value for the latter which, at 1.501095, is noted to differ by an unexpectedly large margin from the experimental value.

  7. A case of 3p deletion syndrome associated with cerebellar hemangioblastoma.

    Science.gov (United States)

    Suzuki-Muromoto, Sato; Hino-Fukuyo, Naomi; Haginoya, Kazuhiro; Kikuchi, Atsuo; Sato, Hiroki; Sato, Yuko; Nakayama, Tojo; Kubota, Yuki; Kakisaka, Yosuke; Uematsu, Mitsugu; Kumabe, Toshihiro; Md, Shigeo Kure

    2016-02-01

    We described clinical course of a 24-year-old woman with 3p deletion syndrome associated with cerebellar hemangioblastoma at the age of 16 years old. She presented dysmorphic facial features, growth retardation and severe psychomotor retardation associated with 3p deletion syndrome. We identified de novo 3p deletion encompassing p25 by using array-based comparative genomic hybridization, where causative gene of von Hippel-Lindau (VHL) disease located. Surgical therapy for cerebellar hemangioblastoma was performed, and histological examination was consistent in cerebellar hemangioblastoma. She showed no other tumors associated VHL disease till 24 years old. This is the first case report of a patient with 3p deletion syndrome whose cerebellar hemangioblastoma may be associated with VHL disease. Repeat imaging studies were recommended for the patients with 3p deletion syndrome. PMID:26365017

  8. Saccharomyces cerevisiae Ngl3p is an active 3′–5′ exonuclease with a specificity towards poly-A RNA reminiscent of cellular deadenylases

    DEFF Research Database (Denmark)

    Feddersen, Ane; Dedic, Emil; Poulsen, Esben Guldahl;

    2012-01-01

    Deadenylation is the first and rate-limiting step during turnover of mRNAs in eukaryotes. In the yeast, Saccharomyces cerevisiae, two distinct 3′–5′ exonucleases, Pop2p and Ccr4p, have been identified within the Ccr4-NOT deadenylase complex, belonging to the DEDD and Exonuclease–Endonuclease–Phosphatase......RNAs that yeast Ngl3p is a functional 3′–5′ exonuclease most active at slightly acidic conditions. We further show that the enzyme depends on divalent metal ions for activity and possesses specificity towards poly-A RNA similar to what has been observed for cellular deadenylases. The results suggest that Ngl3p...

  9. Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction.

    Science.gov (United States)

    Thayer, Kelly M; Beyer, George A

    2016-01-01

    The ubiquitin ligase MDM2, a principle regulator of the tumor suppressor p53, plays an integral role in regulating cellular levels of p53 and thus a prominent role in current cancer research. Computational analysis used MUMBO to rotamerize the MDM2-p53 crystal structure 1YCR to obtain an exhaustive search of point mutations, resulting in the calculation of the ΔΔG comprehensive energy landscape for the p53-bound regulator. The results herein have revealed a set of residues R65-E69 on MDM2 proximal to the p53 hydrophobic binding pocket that exhibited an energetic profile deviating significantly from similar residues elsewhere in the protein. In light of the continued search for novel competitive inhibitors for MDM2, we discuss possible implications of our findings on the drug discovery field. PMID:26992014

  10. Detection of G3P[3] and G3P[9] rotavirus strains in American Indian children with evidence of gene reassortment between human and animal rotaviruses.

    Science.gov (United States)

    Grant, Lindsay; Esona, Mathew; Gentsch, Jon; Watt, James; Reid, Raymond; Weatherholtz, Robert; Santosham, Mathuram; Parashar, Umesh; O'Brien, Katherine

    2011-07-01

    The distribution and evolution of human rotavirus strains is important for vaccine development and effectiveness. In settings where rotavirus vaccine coverage is high, vaccine pressure could select for replacement of common strains (similar to those included in rotavirus vaccines) with uncommon strains, some of which could be generated by reassortment between human and animal rotaviruses. Between 2002 and 2004, a phase-III rotavirus vaccine clinical trial was conducted among American Indian children of the Navajo and White Mountain Apache tribes, which are known to be at high risk for rotavirus diarrhea. We evaluated the rotavirus strains collected from study participants who received placebo during the trial to determine the distribution of rotavirus genotypes and to detect emerging strains that contribute to disease and could influence rotavirus vaccine effectiveness. Three uncommon strains of human rotavirus, two G3P[3] and one G3P[9] strains were detected in stools of children aged 3 to 6 months of age. Segments of all 11 rotavirus genes were sequenced and genotyped by comparison of cognate gene fragments with reference strains. The G3P[3] strains had similar genotypes to each other and to reference dog and cat strains. The G3P[9] strain had similar genotypes to cow, cat and dog reference strains. Genetic analyses of these three strains support the known diversity generating mechanisms of rotavirus. PMID:21567432

  11. Further evidence for clustering of human GABA[sub A] receptor subunit genes: Localization of the [alpha][sub 6]-subunit gene (GABRA6) to distal chromosome 5q by linkage analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hicks, A.A.; Kamphuis, W.; Darlison, M.G. (MRC Molecular Neurobiology Unit, Cambride (United Kingdom)); Bailey, M.E.S.; Johnson, K.J. (Charing Cross and Westminster Medical School, London (United Kingdom)); Riley, B.P. (St. Mary' s Hospital Medical School, London (United Kingdom)); Siciliano, M.J. (Univ. of Texas M.D. Anderson Cancer Center, Houston, TX (United States))

    1994-03-15

    GABA[sub A] receptors are hetero-oligomeric ion-channel complexes that are composed of combinations of [alpha], [beta], [gamma], and [delta] subunits and play a major role in inhibitory neurotransmission in the mammalian brain. The authors report here a microsatellite polymorphism within the human [alpha][sub 6]-subunit gene (GABRA6). Mapping of this marker in a human-hamster hybrid cell-line panel and typing of the repeat in the Centre d'Etude du Polymorphisme Humain (CEPH) reference families enabled the localization of this gene to chromosome 5q and established its linkage to the GABA[sub A] receptor [alpha][sub 1]-subunit gene (GA-BRA1) with a maximum lod score (Z[sub max]) of 39.87 at a [theta] of 0.069 (males) and 0.100 (females). These results reveal the clustering of GABRA6, GABRA1, and the GABA[sub A] receptor [gamma][sub 2]-subunit gene (GABRG2) on distal chromosome 5q. 17 refs., 1 fig., 1 tab.

  12. Identification of lysines within membrane-anchored Mga2p120 that are targets of Rsp5p ubiquitination and mediate mobilization of tethered Mga2p90

    OpenAIRE

    Bhattacharya, Sabyasachi; Shcherbik, Natalia; Vasilescu, Julian; Smith, Jeffrey C.; Figeys, Daniel; Haines, Dale S.

    2008-01-01

    Mga2p90 is an endoplasmic reticulum (ER) localized transcription factor that is released from the ER membrane by a unique ubiquitin-dependent mechanism. Mga2p90 mobilization requires poly-ubiquitination of its associating membrane-bound Mga2p120 anchor and subsequent Mga2p120-Mga2p90 complex disassembly that is mediated by ATPase Cdc48p and its heteromeric ubiquitin-binding adaptor Npl4p-Ufd1p. Although previous studies have identified the ubiquitin ligase (i.e. Rsp5p) and ligase binding site...

  13. Formation and decay of (3P(J))O atoms in the laser flash photolysis of chlorine dioxide (OClO) at 308 nm

    Science.gov (United States)

    Colussi, A. J.

    1990-01-01

    The quantum yields of O(3P(J)) and Cl(2P(3/2)) atoms released in the laser flash photolysis of OClO at 308 and 298 K were determined and the kinetics of the subsequent oxygen atom decay was investigated using time-resolved atomic resonance fluorescence measurements. The results are consistent with the formation of sym-ClO3 having a Delta Hf(ClO3) (formed in the reaction O + OClO + Ar) of 55.6 +/-4 kcal/mol.

  14. Survey on Distributed Data Mining in P2P Networks

    CERN Document Server

    T, Rekha Sunny

    2012-01-01

    The exponential increase of availability of digital data and the necessity to process it in business and scientific fields has literally forced upon us the need to analyze and mine useful knowledge from it. Traditionally data mining has used a data warehousing model of gathering all data into a central site, and then running an algorithm upon that data. Such a centralized approach is fundamentally inappropriate due to many reasons like huge amount of data, infeasibility to centralize data stored at multiple sites, bandwidth limitation and privacy concerns. To solve these problems, Distributed Data Mining (DDM) has emerged as a hot research area. Careful attention in the usage of distributed resources of data, computing, communication, and human factors in a near optimal fashion are paid by distributed data mining. DDM is gaining attention in peer-to-peer (P2P) systems which are emerging as a choice of solution for applications such as file sharing, collaborative movie and song scoring, electronic commerce, an...

  15. An Effective Calculation of Reputation in P2P Networks

    Directory of Open Access Journals (Sweden)

    RVVSV Prasad

    2009-07-01

    Full Text Available With the advent of sophisticated networking technologies and the related applications, more and more computers are getting hooked to the Internet. This is mainly for utilizing several services ranging from information sharing to electronic transactions. P2P networks which allow decentralized systems, have posed problems related to trust when transactions have to be carried out. Current literature proposes several solutions for trust management and reputation computation. The solutions base their assessment of reputations on the number of successful transactions or on the similarity of the feedbacks. There are some concerns in the feedback ratings if we are not considering the issues like number of transactions, frequency of transactions with the same peer and different peers, age of transaction, how frequently a given peer attends a common vendor, and the number of common vendors between the pairs. This paper puts forward a reputation computation system addressing these concerns. It implicitly allows detection of malicious peers. It also incorporates a corrective mechanism, if the feedbacks are from more number of malicious peers. The implementations and the results that support our claims are also presented.

  16. Ternary complex formation of Ino2p-Ino4p transcription factors and Apl2p adaptin beta subunit in yeast.

    Science.gov (United States)

    Nikawa, Jun-ichi; Yata, Masako; Motomura, Miki; Miyoshi, Nobutaka; Ueda, Tsuyoshi; Hisada, Daisuke

    2006-11-01

    Yeast Ino2p-Ino4p heterodimeric complex is well known as a transcriptional activator for the genes regulated by inositol and choline, such as the INO1 gene. Apl2p is a large subunit of the yeast adaptin complex, an adaptor complex required for the clathrin coat to bind to the membrane. We found that Ino2p, Ino4p, and Apl2p form a ternary complex. This interaction was initially observed in a yeast two-hybrid study and subsequently verified by co-immunoprecipitation. Ino2p and Ino4p bind to Apl2p in the same region of Apl2p, viz., at the middle part and the C-terminal part. Ino2p and Ino4p bind to Apl2p independently, but more strongly when both are present. Furthermore, a disruption of APL2 together with INO2 or INO4 rendered yeast cells sensitive to oxidative stress. INO2-APL2 double disruptants also showed growth inability in non-fermentable carbon sources, such as glycerol. These results indicate a genetic interaction between APL2, INO2 and INO4 and uncovere novel functions of the Ino2p-Ino4p-Apl2p complex in yeast. PMID:17090927

  17. Electronic and Rovibrational Quantum Chemical Analysis of C$_3$P$^-$: The Next Interstellar Anion?

    CERN Document Server

    Fortenberry, Ryan C

    2015-01-01

    C$_3$P$^-$ is analogous to the known interstellar anion C$_3$N$^-$ with phosphorus replacing the nitrogen in a simple step down the periodic table. In this work, it is shown that C$_3$P$^-$ is likely to possess a dipole-bound excited state. It has been hypothesized and observationally supported that dipole-bound excited states are an avenue through which anions could be formed in the interstellar medium. Additionally, C$_3$P$^-$ has a valence excited state that may lead to further stabilization of this molecule, and C$_3$P$^-$ has a larger dipole moment than neutral C$_3$P ($\\sim 6$ D vs. $\\sim 4$ D). As such, C$_3$P$^-$ is probably a more detectable astromolecule than even its corresponding neutral radical. Highly-accurate quantum chemical quartic force fields are also applied to C$_3$P$^-$ and its singly $^{13}$C substituted isotopologues in order to provide structures, vibrational frequencies, and spectroscopic constants that may aid in its detection.

  18. Electronic and rovibrational quantum chemical analysis of C3P-: the next interstellar anion?

    Science.gov (United States)

    Fortenberry, Ryan C.; Lukemire, Joseph A.

    2015-11-01

    C3P- is analogous to the known interstellar anion C3N- with phosphorus replacing nitrogen in a simple step down the periodic table. In this work, it is shown that C3P- is likely to possess a dipole-bound excited state. It has been hypothesized and observationally supported that dipole-bound excited states are an avenue through which anions could be formed in the interstellar medium. Additionally, C3P- has a valence excited state that may lead to further stabilization of this molecule, and C3P- has a larger dipole moment than neutral C3P (˜6 D versus ˜4 D). As such, C3P- is probably a more detectable astromolecule than even its corresponding neutral radical. Highly accurate quantum chemical quartic force fields are also applied to C3P- and its singly 13C substituted isotopologues in order to provide structures, vibrational frequencies, and spectroscopic constants that may aid in its detection.

  19. Progress on the Multiphysics Capabilities of the Parallel Electromagnetic ACE3P Simulation Suite

    Energy Technology Data Exchange (ETDEWEB)

    Kononenko, Oleksiy [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-03-26

    ACE3P is a 3D parallel simulation suite that is being developed at SLAC National Accelerator Laboratory. Effectively utilizing supercomputer resources, ACE3P has become a key tool for the coupled electromagnetic, thermal and mechanical research and design of particle accelerators. Based on the existing finite-element infrastructure, a massively parallel eigensolver is developed for modal analysis of mechanical structures. It complements a set of the multiphysics tools in ACE3P and, in particular, can be used for the comprehensive study of microphonics in accelerating cavities ensuring the operational reliability of a particle accelerator.

  20. Sizeable beta-strength in {sup 31}Ar (β3p) decay

    Energy Technology Data Exchange (ETDEWEB)

    Koldste, G.T. [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Blank, B. [Centre d' Études Nucléaire de Bordeaux-Gradignan, CNRS/IN2P3 – Université Bordeaux I, F-33175 Gradignan Cedex (France); Borge, M.J.G.; Briz, J.A.; Carmona-Gallardo, M. [Instituto de Estructura de la Materia, CSIC, E-28006 Madrid (Spain); Fraile, L.M. [Grupo de Física Nuclear, Universidad Complutense, CEI Moncloa, E-28040 Madrid (Spain); Fynbo, H.O.U. [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Giovinazzo, J. [Centre d' Études Nucléaire de Bordeaux-Gradignan, CNRS/IN2P3 – Université Bordeaux I, F-33175 Gradignan Cedex (France); Johansen, J.G. [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Jokinen, A. [Department of Physics, University of Jyväskylä, FIN-40351 Jyväskylä (Finland); Jonson, B. [Fundamental Fysik, Chalmers Tekniska Högskola, S-41296 Göteborg (Sweden); Kurturkian-Nieto, T. [Centre d' Études Nucléaire de Bordeaux-Gradignan, CNRS/IN2P3 – Université Bordeaux I, F-33175 Gradignan Cedex (France); Nilsson, T. [Fundamental Fysik, Chalmers Tekniska Högskola, S-41296 Göteborg (Sweden); Perea, A.; Pesudo, V. [Instituto de Estructura de la Materia, CSIC, E-28006 Madrid (Spain); and others

    2014-10-07

    We present for the first time precise spectroscopic information on the recently discovered decay mode β-delayed 3p-emission. The detection of the 3p events gives an increased sensitivity to the high energy part of the Gamow–Teller strength distribution from the decay of {sup 31}Ar revealing that as much as 30% of the strength resides in the β3p-decay mode. A simplified description of how the main decay modes evolve as the excitation energy increases in {sup 31}Cl is provided.

  1. Specific production of very long-lived core-excited sulfur atoms by 2p{sup -1}{sigma}* excitation of the OCS molecule followed by ultrafast dissociation

    Energy Technology Data Exchange (ETDEWEB)

    Fink, Reinhold F [Department of Physics, Uppsala University, Box 530, SE-751 21 Uppsala (Sweden); Eschner, Annika [Department of Synchrotron Radiation Research, Institute of Physics, University of Lund, Box 118, SE-221 00 Lund (Sweden); Magnuson, Martin [Department of Physics, Uppsala University, Box 530, SE-751 21 Uppsala (Sweden); Bjoerneholm, Olle [Department of Physics, Uppsala University, Box 530, SE-751 21 Uppsala (Sweden); Hjelte, Ingela [Department of Physics, Uppsala University, Box 530, SE-751 21 Uppsala (Sweden); Miron, Catalin [MAXLAB, University of Lund, Box 118, SE-221 00 Lund (Sweden); Bassler, Margit [MAXLAB, University of Lund, Box 118, SE-221 00 Lund (Sweden); Svensson, Svante [Department of Physics, Uppsala University, Box 530, SE-751 21 Uppsala (Sweden); Piancastelli, Maria Novella [Department of Physics, Uppsala University, Box 530, SE-751 21 Uppsala (Sweden); Sorensen, Stacey L [Department of Synchrotron Radiation Research, Institute of Physics, University of Lund, Box 118, SE-221 00 Lund (Sweden)

    2006-06-28

    A core-excited sulfur state with a lifetime almost one order of magnitude longer than in molecular 2p core-hole states is selectively produced by ultrafast dissociation of S 2p {yields} {sigma}* excited OCS. Clear evidence for this is provided by strong atomic peaks (20% of the total intensity) in x-ray fluorescence but very weak ones (2%) in the corresponding resonant Auger spectrum. Corroborating the assignment of the spectra, ab initio calculations explain the enhanced lifetime: the Auger decay of the produced {sup 3}D{sub 3} (2p{sup 5}3p{sup 5}) sulfur state is strongly decreased as it contradicts a newly derived propensity rule of the L{sub 2,3}MM Auger decay. (letter to the editor)

  2. Isotope shifts of the (3s3p) 3P0,1,2-(3s4s) 3S1 Mg I transitions

    DEFF Research Database (Denmark)

    He, Ming; Therkildsen, Kasper T.; Jensen, Brian B.;

    2009-01-01

    We report measurements of the isotope shifts of the (3s3p)P30,1,2-(3s4s)S31 Mg I transitions for the stable isotopes M24g (I=0) , M25g (I=5/2) , and M26g (I=0) . Furthermore, the M25g S31 hyperfine coefficient A(S31)=(-321.6±1.5)MHz is extracted and found to be in excellent agreement with state...

  3. Ab-initio calculation of the 2s21S0-2s3p 3P1 intercombination transition in beryllium-like ions

    International Nuclear Information System (INIS)

    Transition probabilities of the 2s21S0-2s3p 1,3P1 intercombination and resonance lines have been calculated for 14 beryllium-like ions in the atomic range 7 ≤ Z ≤ 36. We used multiconfiguration Dirac-Fock wave functions to explore the effects of configuration interaction, of electron rearrangement as well as of relativity in a consistent scheme along the isoelectronic sequence. To show the number of configurations needed in a proper expansion of the wave functions we systematically enlarged the basis from small to large-scale. For the low-Z elements, virtual excitations of the 2s and 3p electrons up to the 5l subshells contribute significantly to the intercombination probability even though the transition energies remain almost unaffected by excitations beyond the 3l shells. The incomplete orthogonality of the orbital functions due to the rearrangement of the electron density clearly shifts the intercombination rates and appears to be independent of the configuration expansion. This effect decreases, as expected, at higher nuclear charges. (orig.)

  4. Determination of diffusion, reflection and deexcitation coefficients of metastable excited Ne(3P2) atom

    Science.gov (United States)

    Suzuki, S.; Itoh, H.

    2016-05-01

    The diffusion coefficient of the metastable excited Ne(3P2) atom in neon, the reflection coefficient of Ne(3P2) at the surface of an electrode and the rate coefficient of Ne(3P2) for collisional quenching by Ne(1S0) were determined from the gas pressure dependence of the effective lifetime of Ne(3P2). The effective lifetime of Ne(3P2) was measured from the transient current after turning off the Ultraviolet (UV) light in a Townsend discharge. The observed transient current waveform was analysed by solving the diffusion equation for the metastable excited Ne(3P2) atom using the third kind of boundary condition. The rate coefficient of Ne(3P2) for collisional quenching by Ne(1S0) and the reflection coefficient were determined by a nonspectroscopic method for the first time in neon to the best of our knowledge and were (3.2  ±  0.4)  ×  10‑16 cm3 s‑1 and 0.10  ±  0.04, respectively. The obtained diffusion coefficient at 1 Torr was 177  ±  17 cm2 s‑1, which is consistent with the value reported by Dixon and Grant. Moreover, the present results are compared with the results of Phelps and were found to be in good agreement. We also discuss the deexcitation rate of Ne(3P2) at pressures of up to 60 Torr in comparison with previously reported values.

  5. MiR-373-3p Promotes Invasion and Metastasis of Lung Adenocarcinoma Cells

    Directory of Open Access Journals (Sweden)

    Aibing WU

    2015-07-01

    Full Text Available Background and objective Lung cancer is the leading cause of cancer-related deaths worldwide, and metastasis is the major cause of death in lung cancer patients. MiR-373 is closely associated with invasion and metastasis in other tumor cells. This study explored the expression of miR-373-3p in non-small cell lung cancer (NSCLC and its effect on the invasive and metastatic capabilities of lung adenocarcinoma cells, as well as their mechanisms of action. Methods The expression of miR-373-3p in NSCLC tissues and lung adenocarcinoma cell lines was detected by quantitative reverse transcription polymerase chain reaction. The roles of miR-373-3p in regulating lung adenocarcinoma cell invasion and metastatic properties were analyzed with miR-373-3p mimic/inhibitor-transfected cells via Transwell chamber assay. Matrix metalloproteinase MMP-9 and MMP-14 protein levels were detected by Western blot in lung cancer cells after transfection. Results MiR-373-3p was upregulated in 51 NSCLC tissues and 5 NSCLC cell lines. Gain-of-function and loss-of-function studies showed that overexpression of miR-373-3p promoted H1299 cell migration and invasion, which resulted in upregulation of MMP-9 and MMP-14. By contrast, miR-373-3p knockdown inhibited these processes in A549 cells and downregulated the expression of MMP-9 and MMP-14. Conclusion Our results demonstrated that miR-373-3p participated in the invasion and metastasis of lung adenocarcinoma cells, partly by upregulation of MMP-9 and MMP-14.

  6. Protective role of miR-23b-3p in kainic acid-induced seizure.

    Science.gov (United States)

    Zhan, Lianbo; Yao, Yi; Fu, Huajun; Li, Zhenghui; Wang, Fengpeng; Zhang, Xiaobin; He, Wencan; Zheng, Weihong; Zhang, Yunwu; Zheng, Honghua

    2016-07-01

    Dysregulation of microRNAs has been proposed to contribute toward epilepsy. The miRNA miR-23b-3p has been found to protect against neuronal apoptosis and the production of reactive oxygen species. In this study, we assessed the potential role of miR-23b-3p in the kainic acid (KA)-induced seizure model. We found that miR-23b-3p levels were significantly decreased in the brain cortex of mice and in cultured mouse primary neurons treated with KA. Importantly, supplement of miR-23b-3p agomir by an intacerebroventricular injection alleviated seizure behaviors and abnormal cortical electroencephalogram recordings in KA-treated mice. Together, these results indicate that miR-23b-3p plays a crucial role in suppressing seizure formation in experimental models of epilepsy and that miR-23b-3p supplement may be a potential anabolic strategy for ameliorating seizure. PMID:27232518

  7. Cu3P/RGO Nanocomposite as a New Anode for Lithium-Ion Batteries

    Science.gov (United States)

    Liu, Shuling; He, Xiaodong; Zhu, Jianping; Xu, Liqiang; Tong, Jianbo

    2016-10-01

    Cu3P/reduced graphene oxide (Cu3P/RGO) nanocomposite was successfully synthesized by a facile one-pot method as an advanced anode material for high-performance lithium-ion batteries. Cu3P nanostructures with a polyhedral shape with the mean diameter (80–100 nm) were homogeneously anchored on the surface of RGO. The flexible RGO sheets acted as elastic buffering layer which not only reduced the volume change, but also prevented the aggregation of Cu3P nanostructures, the cracking and crumbing of electrodes. On the other hand, the presence of Cu3P nanostructures could also avoid the agglomeration of RGO sheets and retain their highly active surface area. Therefore, as an advanced anode material for high-performance lithium-ion batteries, the as-prepared Cu3P/RGO exhibited high capacity of 756.15 mAhg‑1 at the current density 500 mAg‑1 after 80 cycles, superior cyclic stability and good rate capability.

  8. Effect of Fe2P in LiFePO4/Fe2P composite on electrochemical properties synthesized by MA and control of heat condition

    Institute of Scientific and Technical Information of China (English)

    PARK Jong Suk; LEE Kyung Tae; LEE Kyung Sub

    2006-01-01

    In order to control the size and distribution of the high conductive Fe2P in LiFePO4/Fe2P composite, two different cooling rates (Fast: 15 ℃·min-1, Slow: 2 ℃·min-1) were employed after mechanical alloying.The discharge capacity of the fast cooled was 83 mAh·g-1 and the slow cooled 121 mAh·g-1.The particle size of the synthesized powder was examined by transmission electron microscopy and distribution of Fe2P was characterized using scanning electron microscopy (SEM).In addition, two-step heat treatment was carried out for better distribution of Fe2P.X-ray diffraction (XRD) and Rietveld refinement reveal that LiFePO4/Fe2P composite consists of 95.77% LiFePO4 and 4.33% of Fe2P.

  9. Multiplex FISH telomere integrity assay identifies an unbalanced cryptic translocation der(5)t(3;5)(q27;p15.3) in a family with three mentally retarded individuals.

    Science.gov (United States)

    Granzow, M; Popp, S; Keller, M; Holtgreve-Grez, H; Brough, M; Schoell, B; Rauterberg-Ruland, I; Hager, H D; Tariverdian, G; Jauch, A

    2000-07-01

    Cryptic rearrangements involving the terminal regions of chromosomes are suspected to be the cause of idiopathic mental retardation in a significant number of cases. This finding highlights the necessity of a primary screening test for such chromosome aberrations. Here we present a multiplex fluorescence in situ hybridization telomere integrity assay which allows the detection of submicroscopic aberrations in the telomeric regions of all chromosomes. This novel approach identified an unbalanced cryptic translocation der(5)t(3;5)(q27;p15.3) in a family with three cases of unexplained mental retardation and dysmorphic features. The symptoms of the patients represent neither the classical dup(3q)- nor cri du chat syndrome, although all affected individuals demonstrate several features of both syndromes. The identification of two balanced translocation carriers emphasizes the significance of the telomere integrity assay for genetic counseling and prenatal diagnosis. PMID:10982035

  10. Genetic epidemiology of Paget's disease of bone in italy: sequestosome1/p62 gene mutational test and haplotype analysis at 5q35 in a large representative series of sporadic and familial Italian cases of Paget's disease of bone.

    Science.gov (United States)

    Falchetti, Alberto; Di Stefano, Marco; Marini, Francesca; Ortolani, Sergio; Ulivieri, Massimo Fabio; Bergui, Simona; Masi, Laura; Cepollaro, Chiara; Benucci, Maurizio; Di Munno, Ombretta; Rossini, Maurizio; Adami, Silvano; Del Puente, Antonio; Isaia, Giancarlo; Torricelli, Francesca; Brandi, Maria Luisa

    2009-01-01

    Families affected by Paget's disease of bone frequently harbor mutations in the SQSTM1/p62 gene. In this multicentric study we collected 345 sporadic and 12 familial PDB cases throughout Italy, identifying 12 different mutations, 5 of which are newly reported and 3, D335E, A381V, and Y383X, external to the UBA domain. Subjects with truncating mutations, E396X, showed a significantly younger age at clinical diagnosis, while the Y383X subjects had a higher average number of affected skeletal sites. All the mutants exhibited the CGTG-H2 haplotype. In two pairs and one triad of unrelated Italian PDB families from different Italian regions, we detected a common SQSTM1/p62 mutation for each P392L, M404V, and G425R group. Since the CGTG-H2 haplotype frequency was also high in normal subjects, and genetic influence due to migratory fluxes of different ethnic groups exists in the Italian population, to refine the search for a more geographically specific founder effect, we extended the haplotype analysis in these families using polymorphic microsatellite repeat markers, within and flanking the SQSTM1/p62 locus, from chromosome 5q35, other than the exon 6 and 3'UTR polymorphisms. All mutant carriers from two of the three M404V families and from the G425R families exhibited common extended chromosome 5q35 haplotypes, IT01 and IT02, respectively, which may be reflecting influences of past migrations. This may be helpful in estimating the true rate of de novo mutations. We confirm the data on the existence of both a mutational hotspot at the UBA domain of SQSTM1/p62 and a founder effect in the PDB population.

  11. Increased miR-132-3p expression is associated with chronic neuropathic pain.

    Science.gov (United States)

    Leinders, M; Üçeyler, N; Pritchard, R A; Sommer, C; Sorkin, L S

    2016-09-01

    Alterations in the neuro-immune balance play a major role in the pathophysiology of chronic neuropathic pain. MicroRNAs (miRNA) can regulate both immune and neuronal processes and may function as master switches in chronic pain development and maintenance. We set out to analyze the role of miR-132-3p, first in patients with peripheral neuropathies and second in an animal model of neuropathic pain. We initially determined miR-132-3p expression by measuring its levels in white blood cells (WBC) of 30 patients and 30 healthy controls and next in sural nerve biopsies of 81 patients with painful or painless inflammatory or non-inflammatory neuropathies based on clinical diagnosis. We found a 2.6 fold increase in miR-132-3p expression in WBC of neuropathy patients compared to healthy controls (panimal model of neuropathic pain, the spared nerve injury model (SNI). For this purpose miR-132-3p expression levels were measured in dorsal root ganglia and spinal cord of rats. Subsequently, miR-132-3p expression was pharmacologically modulated with miRNA antagonists or mimetics, and evoked pain and pain aversion were assessed. Spinal miR-132-3p levels were highest 10days after SNI, a time when persistent allodynia was established (pbehavior in the place escape avoidance paradigm (pbehavior in naïve rats (p<0.001). Taken together these results indicate a pro-nociceptive effect of miR-132-3p in chronic neuropathic pain. PMID:27349406

  12. Adaptive Routing Algorithms in Unstructured Peer-to-Peer (P2P) Systems

    OpenAIRE

    Achmad Nizar Hidayanto; Stephane Bressan

    2011-01-01

    There are a variety of peer-to-peer (P2P) systems for sharing documents currently available. According to their data organization, P2P systems are classified into two categories: structured andunstructured P2P systems. In structured P2P systems, peers are organized according to some mapping techniques, e.g. hashing function. Whereas in unstructured P2P system, peers are connected to each others randomly; resources are not moved to other peers but hosted on site. Unstructured P2P systems offer...

  13. Zn3P2 and Cu2O Substrates for Solar Energy Conversion

    Science.gov (United States)

    Kimball, Gregory Michael

    Zinc phosphide (Zn3P2) and cuprous oxide (Cu 2O) are promising and earth-abundant alternatives to traditional thin film photovoltaics materials such as CIGS, CdTe, and a-Si. We have prepared high purity substrates of Zn3P2 from elemental zinc and phosphorus, and Cu2O by the thermal oxidation of copper foils, to investigate their fundamental material properties and potential for solar energy conversion. Photoluminescence-based measurements of Zn3P2 substrates have revealed a fundamental indirect band gap at 1.38 eV and a direct band gap at 1.50 eV, with time-resolved data indicating minority carrier diffusion lengths of ≥7 μm. Solar cells based on Mg/Zn3P2 junctions with solar energy conversion efficiency reaching 4.5% were examined by composition profiling to elucidate the passivation reaction between Mg metal and Zn3P2 surfaces. Semiconductor/liquid junctions incorporating Cu2O substrates exhibited open-circuit voltage, Voc, values in excess of 800 mV and internal quantum yields approaching 100% in the 400-500 nm spectral range.

  14. QTL Information Table: 5 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Physiological trait Eating quality Grain l/w ratio SSR C)Interval DH from BC3F1 Cai..., C., Bergman, C., and Oard, J.H. (2004). QTL mapping of grain quality traits from the interspecific cross Oryza sativa x O. glaberrima. Theor Appl Genet 109, 630-639. ...

  15. 3p14 De Novo Interstitial Microdeletion in a Patient with Intellectual Disability and Autistic Features with Language Impairment: A Comparison with Similar Cases

    Directory of Open Access Journals (Sweden)

    Ana Belén de la Hoz

    2015-01-01

    Full Text Available To date, few cases of 3p proximal interstitial deletions have been reported and the phenotype and genotype correlation is not well understood. Here, we report a new case of a 3p proximal interstitial deletion. The patient is an 11-year-old female with speech and social interaction difficulties, learning disability, and slight facial dysmorphism, but no other major malformations. An 8 Mb de novo interstitial deletion at 3p14.2-p14.1, from position 60.461.316 to 68.515.453, was revealed by means of array comparative genomic hybridization and confirmed using quantitative reverse-transcription polymerase chain reaction assays. This region includes six genes: FEZF2, CADPS, SYNPR, ATXN7, PRICKLE, and MAGI1, that are known to have a role in neurodevelopment. These genes are located on the proximal side of the deletion. We compare our case with previously well-defined patients reported in the literature and databases.

  16. BOREAS Level-3p Landsat TM Imagery: Geocoded and Scaled At-sensor Radiance

    Science.gov (United States)

    Nickeson, Jaime; Knapp, David; Newcomer, Jeffrey A.; Hall, Forrest G. (Editor); Cihlar, Josef

    2000-01-01

    For BOReal Ecosystem-Atmosphere Study (BOREAS), the level-3p Landsat Thematic Mapper (TM) data were used to supplement the level-3s Landsat TM products. Along with the other remotely sensed images, the Landsat TM images were collected in order to provide spatially extensive information over the primary study areas. This information includes radiant energy, detailed land cover, and biophysical parameter maps such as Fraction of Photosynthetically Active Radiation (FPAR) and Leaf Area Index (LAI). Although very similar to the level-3s Landsat TM products, the level-3p images were processed with ground control information, which improved the accuracy of the geographic coordinates provided. Geographically, the level-3p images cover the BOREAS Northern Study Area (NSA) and Southern Study Area (SSA). Temporally, the four images cover the period of 20-Aug-1988 to 07-Jun-1994. Except for the 07-Jun-1994 image, which contains seven bands, the other three contain only three bands.

  17. A new form of Ca3P2 with a ring of Dirac nodes

    Directory of Open Access Journals (Sweden)

    Lilia S. Xie

    2015-08-01

    Full Text Available We report the synthesis and crystal structure of a new high-temperature form of Ca3P2. The crystal structure was determined through Rietveld refinements of synchrotron powder x-ray diffraction data. This form of Ca3P2 has a crystal structure of the hexagonal Mn5Si3 type, with a Ca ion deficiency compared to the ideal 5:3 stoichiometry. This yields a stable, charge-balanced compound of Ca2+ and P3−. We also report the observation of a secondary hydride phase, Ca5P3H, which again is a charge-balanced compound. The calculated band structure of Ca3P2 indicates that it is a three-dimensional Dirac semimetal with a highly unusual ring of Dirac nodes at the Fermi level. The Dirac states are protected against gap opening by a mirror plane in a manner analogous to what is seen for graphene.

  18. Experimental and theoretical study of 3p photoionization and subsequent Auger decay in atomic chromium

    Science.gov (United States)

    Keskinen, J.; Huttula, S.-M.; Mäkinen, A.; Patanen, M.; Huttula, M.

    2015-12-01

    3p photoionization and subsequent low kinetic energy Coster-Kronig and super Coster-Kronig Auger decay have been studied in atomic chromium. The binding energies, line widths, and relative intensities for the transitions seen in the synchrotron radiation excited 3p photoelectron spectrum are determined. The high resolution M2,3 M4,5 M4,5 and M2,3 M4,5 N1 Auger electron spectra following the electron impact excited 3p ionization are presented and the kinetic energies, relative intensities, and identifications are given for the main lines. The experimental findings are compared with the theoretical predictions obtained from Hartree-Fock and multiconfiguration Dirac-Fock approaches.

  19. Single gene microdeletions and microduplication of 3p26.3 in three unrelated families

    DEFF Research Database (Denmark)

    Kashevarova, Anna A; Nazarenko, Lyudmila P; Schultz-Pedersen, Soren;

    2014-01-01

    BACKGROUND: Detection of submicroscopic chromosomal alterations in patients with a idiopathic intellectual disability (ID) allows significant improvement in delineation of the regions of the genome that are associated with brain development and function. However, these chromosomal regions usually...... contain several protein-coding genes and regulatory elements, complicating the understanding of genotype-phenotype correlations. We report two siblings with ID and an unrelated patient with atypical autism who had 3p26.3 microdeletions and one intellectually disabled patient with a 3p26.3 microduplication...

  20. Absolute frequency measurement of the magnesium intercombination transition $^1S_0 \\to ^3P_1$

    OpenAIRE

    Friebe, Jan; Pape, André; Riedmann, Matthias; Moldenhauer, Karsten; Mehlstäubler, Tanja; Rehbein, Nils; Lisdat, Christian; Rasel, Ernst M.; Ertmer, Wolfgang; Schnatz, Harald; Lipphardt, Burghard; Grosche, Gesine

    2007-01-01

    We report on a frequency measurement of the $(3s^2)^1S_0\\to(3s3p)^3P_1$ clock transition of $^{24}$Mg on a thermal atomic beam. The intercombination transition has been referenced to a portable primary Cs frequency standard with the help of a femtosecond fiber laser frequency comb. The achieved uncertainty is $2.5\\times10^{-12}$ which corresponds to an increase in accuracy of six orders of magnitude compared to previous results. The measured frequency value permits the calculation of several ...

  1. MiR-373-3p Promotes Invasion and Metastasis of Lung Adenocarcinoma Cells

    OpenAIRE

    Wu, Aibing; Jinmei LI; Kunpeng WU; Mo, Yanli; Luo, Yiping; Haiyin YE; Shen, Xiang; Li, Shujun; Yahai LIANG; Liu, Meilian; Yang, Zhixiong

    2015-01-01

    Background and objective Lung cancer is the leading cause of cancer-related deaths worldwide, and metastasis is the major cause of death in lung cancer patients. MiR-373 is closely associated with invasion and metastasis in other tumor cells. This study explored the expression of miR-373-3p in non-small cell lung cancer (NSCLC) and its effect on the invasive and metastatic capabilities of lung adenocarcinoma cells, as well as their mechanisms of action. Methods The expression of miR-373-3p in...

  2. Multi-configuration Dirac-Hartree-Fock calculations of the transition rates of 2s22p2 - 2s2p3 and 2s2p3 - 2s22pnl (n ≥ 3) E1 transitions of N+

    Science.gov (United States)

    Shen, Xiaozhi; Liu, Juan; Zhou, Fuyang

    2016-10-01

    Wavefunctions were determined using the multi-configuration Dirac-Hartree-Fock method. The core-core, core-valence, valence correlation, Breit interaction and quantum electrodynamics effects, as well as some higher-order correlation effects, were considered to obtain accurate wavelengths (λ), oscillator strengths (gf) and transition rates (A) of 2s22p2 - 2s2p3, 2s2p3 - 2s22pnl (n ≥ 3) and 2s2p3 - 2s2p23s E1 transitions. The branching ratio of 2s2p3 5S^o_2 (namely Aλ2143.45/Aλ2139.68) based on the latest calculation of 2.462 ± 0.119 is recommended for the determination of a nebula's electron temperature and electron density. The largest calculated gf value of 2s2p3 - 2s22p4p is λ630.65, differing from that of λ1060.2 (i.e. 2s2p3 3P^o_2 - 2s22p4p 3S1) that was observed with the largest intensities in the Orion Nebula spectrum. In addition, the energy levels and the splittings of 2s2p3, the extremely difficult calculations of the rates of two-electron one-photon transitions as well as those of the very small intercombination A of 2s2p3 5S^o_2 were studied in detail. Because of the weak spin-orbit interaction, accurately calculating the levels 3P^o_{1,2,0} (or 3D^o_{3,2,1}) and their transition matrix elements is very sensitive to relativistic and electron correlation effects. A special case for this is when the transition operators synchronously applied to wavefunctions with regard to 2s2p3 3Po and 2s22pnl (n = 4) become extremely sensitive to some higher-order correlation effects.

  3. Data of evolutionary structure change: 1Q95E-2P2GD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1Q95E-2P2GD 1Q95 2P2G E D ANPLYQKHIISINDLSRDDLNLVLATAAKLKANP-QPEL...LKH-KVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGD...RLDAMASVAT-VPVINALSD-EFHPCQVLADLQTIAERKGALRGLRLSYFGDGAN-NMAHSLLLGGVTAG-IHVTVAAPEGFLPDPSVRAAAERRAQDTGASVTVTAD...AHAAAAGADVLVTDTWV-----KPFRPF-----QLNSRLLALADSDAIVLHCLPAHRGDEITDAVMDGPASAVWDEAENRL.../pdbID> D 2P2GD RPLQG

  4. Music2Share - Copyright-Compliant Music Sharing in P2P Systems (Invited paper)

    NARCIS (Netherlands)

    Kalker, Ton; Epema, Dick H.J.; Hartel, Pieter H.; Lagendijk, R. (Inald) L.; Steen, van Maarten

    2004-01-01

    Peer-to-Peer (P2P) networks are generally considered to be free havens for pirated content, in particular with respect to music. We describe a solution for the problem of copyright infringement in P2P networks for music sharing. In particular, we propose a P2P protocol that integrates the functions

  5. Systems genetics analyses predict a transcription role for P2P-R: Molecular confirmation that P2P-R is a transcriptional co-repressor

    Directory of Open Access Journals (Sweden)

    Giannakouros Thomas

    2010-02-01

    Full Text Available Abstract Background The 250 kDa P2P-R protein (also known as PACT and Rbbp6 was cloned over a decade ago and was found to bind both the p53 and Rb1 tumor suppressor proteins. In addition, P2P-R has been associated with multiple biological functions, such as mitosis, mRNA processing, translation and ubiquitination. In the current studies, the online GeneNetwork system was employed to further probe P2P-R biological functions. Molecular studies were then performed to confirm the GeneNetwork evaluations. Results GeneNetwork and associated gene ontology links were used to investigate the coexpression of P2P-R with distinct functional sets of genes in an adipocyte genetic reference panel of HXB/BXH recombinant strains of rats and an eye genetic reference panel of BXD recombinant inbred strains of mice. The results establish that biological networks of 75 and 135 transcription-associated gene products that include P2P-R are co-expressed in a genetically-defined manner in rat adipocytes and in the mouse eye, respectively. Of this large set of transcription-associated genes, >10% are associated with hormone-mediated transcription. Since it has been previously reported that P2P-R can bind the SRC-1 transcription co-regulatory factor (steroid receptor co-activator 1, [Ncoa1], the possible effects of P2P-R on estrogen-induced transcription were evaluated. Estrogen-induced transcription was repressed 50-70% by the transient transfection of P2P-R plasmid constructs into four different cell types. In addition, knockdown of P2P-R expression using an antisense oligonucleotide increased estrogen-mediated transcription. Co-immunoprecipitation assays confirmed that P2P-R interacts with SRC-1 and also demonstrated that P2P-R interacts with estrogen receptor α. Conclusions The findings presented in this study provide strong support for the value of systems genetics, especially GeneNetwork, in discovering new functions of genes that can be confirmed by molecular

  6. Observation of the Forbidden Magnetic Dipole Transition 6{sup 2}P{sub ½} --> 7{sup 2}P{sub ½} in Atomic Thallium

    Science.gov (United States)

    Chu, S.

    1976-10-01

    A measurement of the 6{sup 2}P{sub ½} --> 7{sup 2}P{sub ½} forbidden magnetic dipole matrix element in atomic thallium is described. A pulsed, linearly polarized dye laser tuned to the transition frequency is used to excite the thallium vapor from the 6{sup 2}P{sub ½} ground state to the 7{sup 2}P{sub ½} excited state. Interference between the magnetic dipole M1 amplitude and a static electric field induced E1 amplitude results in an atomic polarization of the 7{sup 2}P{sub ½} state, and the subsequent circular polarization of 535 nm fluorescence. The circular polarization is seen to be proportional to / as expected, and measured for several transitions between hyperfine levels of the 6{sup 2}P{sub ½} and 7{sup 2}P{sub ½} states. The result is = -(2.11 +- 0.30) x 10{sup -5} parallel bar e parallel bar dirac constant/2mc, in agreement with theory.

  7. miR-141-3p inhibits human stromal (mesenchymal) stem cell proliferation and differentiation

    DEFF Research Database (Denmark)

    Qiu, Weimin; Kassem, Moustapha

    2014-01-01

    Wnt signaling determines human stromal (mesenchymal) stem cell (hMSC) differentiation fate into the osteoblast or adipocyte lineage. microRNAs (miRNAs) are small RNA molecules of 21-25 nucleotides that regulate many aspects of osteoblast biology. Thus, we examined miRNAs regulated by Wnt signaling...... in hMSC. We identified miRNA (miR)-141-3p as a Wnt target which in turn inhibited Wnt signaling. Moreover, miR-141-3p inhibited hMSC proliferation by arresting cells at the G1 phase of the cell cycle. miR-141-3p inhibited osteoblast differentiation of hMSC as evidenced by reduced alkaline phosphatase...... activity, gene expression and in vitro mineralized matrix formation. Bioinformatic studies, Western blot analysis and 3'UTR reporter assay demonstrated that cell division cycle 25A (CDC25A) is a direct target of miR-141-3p. siRNA-mediated knock-down of CDC25A inhibited hMSC proliferation and osteoblast...

  8. The infinite order point on Y~2=X~3-p~3

    Institute of Scientific and Technical Information of China (English)

    张绍伟

    1995-01-01

    The parameterization of the elliptic curve Y2=X2+1 is given by using the modular forms of X(12) Then using class field theory over imaginary quadratic field and Shimura reciprocity, an infinite order point on the curve y2- = x3-p3 is constructed, for prime p=7 (mod 24).

  9. Canine-origin G3P[3] rotavirus strain in child with acute gastroenteritis.

    Science.gov (United States)

    De Grazia, Simona; Martella, Vito; Giammanco, Giovanni M; Gòmara, Miren Iturriza; Ramirez, Stefania; Cascio, Antonio; Colomba, Claudia; Arista, Serenella

    2007-07-01

    Infection by an animal-like strain of rotavirus (PA260/97) was diagnosed in a child with gastroenteritis in Palermo, Italy, in 1997. Sequence analysis of VP7, VP4, VP6, and NSP4 genes showed resemblance to a G3P[3] canine strain identified in Italy in 1996. Dogs are a potential source of human viral pathogens. PMID:18214189

  10. Repumping of ultracold strontium atoms using the ^3P2 - ^3D2 transition

    Science.gov (United States)

    Mickelson, P. G.; Martinez de Escobar, Y. N.; Traverso, A. J.; Killian, T. C.

    2008-05-01

    We discuss recent experiments involving ultracold strontium. Using a commercially-available 3 micron laser, we repump atoms out of the ^3P2 level via the ^3D2 state and gain almost a factor of 10 in the number of atoms in our system. This increase in the signal-to-noise ratio enables improved spectroscopy of strontium in our optical trap.

  11. Canine-Origin G3P[3] Rotavirus Strain in Child with Acute Gastroenteritis

    OpenAIRE

    De Grazia, Simona; Martella, Vito; Giammanco, Giovanni M; Gòmara, Miren Iturriza; Ramirez, Stefania; Cascio, Antonio; Colomba, Claudia; Arista, Serenella

    2007-01-01

    Infection by an animal-like strain of rotavirus (PA260/97) was diagnosed in a child with gastroenteritis in Palermo, Italy, in 1997. Sequence analysis of VP7, VP4, VP6, and NSP4 genes showed resemblance to a G3P[3] canine strain identified in Italy in 1996. Dogs are a potential source of human viral pathogens.

  12. Synthesization of the Ar VIII 3s-3p beam-foil decay curve

    International Nuclear Information System (INIS)

    The beam-foil decay curve for the 3s-3p transition in Ar VIII has been simulated from experimentally determined relative initial level populations and transition probabilities calculated in the numerical Coulomb approximation. Good agreement is observed between simulated and measured decay curves. A discussion of the simulation is given. (Auth.)

  13. miR-200a-3p regulates TLR1 expression in bacterial challenged miiuy croaker.

    Science.gov (United States)

    Wang, Yanjin; Xu, Guoliang; Han, Jingjing; Xu, Tianjun

    2016-10-01

    MicroRNAs (miRNAs) are highly conserved, small non-coding RNAs which post-transcriptionally regulate various biological processes by repressing mRNA translation or degradating mRNA. It has been demonstrated that miRNAs play crucial roles in regulating the immune system. In this study, we explored the potential roles of miR-200a-3p in regulating TLR signaling pathway in miiuy croaker. Bioinformatics analysis showed that miiuy croaker TLR1 (mmiTLR1) was a putative target of miR-200a-3p. Negative expression profiles in spleen of Vibrio anguillarum challenged miiuy croaker and in lipopolysaccharide (LPS) stimulated miiuy croaker leukocytes further validated the prediction. Luciferase reporter assays showed that the dual-luciferase reporter fused to the 3'UTR of wild type mmiTLR1 cotransfected with miR-200a-3p mimics exhibited a reduction in luciferase activity compared with the controls. All of the present data provide direct evidence that miR-200a-3p is involved in TLR1 expression modulation in miiuy croaker, which will offer a basis for better understanding of miRNA regulation in fish TLR signaling pathways. PMID:27288848

  14. miR-511-3p Modulates Genetic Programs of Tumor-Associated Macrophages

    Directory of Open Access Journals (Sweden)

    Mario Leonardo Squadrito

    2012-02-01

    Full Text Available Expression of the mannose receptor (MRC1/CD206 identifies macrophage subtypes, such as alternatively activated macrophages (AAMs and M2-polarized tumor-associated macrophages (TAMs, which are endowed with tissue-remodeling, proangiogenic, and protumoral activity. However, the significance of MRC1 expression for TAM's protumoral activity is unclear. Here, we describe and characterize miR-511-3p, an intronic microRNA (miRNA encoded by both mouse and human MRC1 genes. By using sensitive miRNA reporter vectors, we demonstrate robust expression and bioactivity of miR-511-3p in MRC1+ AAMs and TAMs. Unexpectedly, enforced expression of miR-511-3p tuned down the protumoral gene signature of MRC1+ TAMs and inhibited tumor growth. Our findings suggest that transcriptional activation of Mrc1 in TAMs evokes a genetic program orchestrated by miR-511-3p, which limits rather than enhances their protumoral functions. Besides uncovering a role for MRC1 as gatekeeper of TAM's protumoral genetic programs, these observations suggest that endogenous miRNAs may operate to establish thresholds for inflammatory cell activation in tumors.

  15. Linkage of atopic dermatitis to chromosomes 4q22, 3p24 and 3q21

    DEFF Research Database (Denmark)

    Christensen, Ulla; Møller-Larsen, Steffen; Nyegaard, Mette;

    2009-01-01

    Atopic dermatitis (AD) is a common, itchy skin disease of complex inheritance characterized by dermal and epidermal inflammation. The heritability is considerable and well documented. To date, four genome scans have examined the AD phenotype, showing replicated linkage at 3p26-22, 3q13-21 and 18q11...

  16. Toward a 3-P Model of Workplace Learning: A Literature Review

    Science.gov (United States)

    Tynjala, Paivi

    2013-01-01

    The interest in research focusing on learning taking place at work, through work and for work has considerably increased over the past two decades. The purpose of the paper is to review and structure this wide and diverse research field. A tentative holistic model--the 3-P model of workplace learning--is presented, in relation to which the…

  17. 3P2-3F2 pairing in dense neutron matter: the spectrum of solutions

    International Nuclear Information System (INIS)

    The 3P2-3F2 pairing model is generally considered to provide an adequate description of the superfluid states of neutron matter at densities some 2-3 times that of saturated symmetrical nuclear matter. The problem of solving the system of BCS gap equations expressing the 3P2-3F2 model is attacked with the aid of the separation approach. This method, developed originally for quantitative study of S-wave pairing in the presence of strong short-range repulsions, serves effectively to reduce the coupled, singular, nonlinear BCS integral equations to a set of coupled algebraic equations. For the first time, sufficient precision becomes accessible to resolve small energy splittings between the different pairing states. Adopting a perturbative strategy, we are able to identify and characterize the full repertoire of real solutions of the 3P2-3F2 pairing model, in the limiting regime of small tensor-coupling strength. The P-F channel coupling is seen to lift the striking parametric degeneracies revealed by a earlier separation treatment of the pure, uncoupled 3P2 pairing problem. Remarkably, incisive and robust results are obtained solely on the basis of analytic arguments. Unlike the traditional Ginzburg-Landau approach, the analysis is not restricted to the immediate vicinity of the critical temperature, but is equally reliable at zero temperature. Interesting connections and contrasts are drawn between triplet pairing in dense neutron matter and triplet pairing in liquid 3He

  18. Evolutionary divergence of Ure2pA glutathione transferases in wood degrading fungi.

    Science.gov (United States)

    Roret, Thomas; Thuillier, Anne; Favier, Frédérique; Gelhaye, Eric; Didierjean, Claude; Morel-Rouhier, Mélanie

    2015-10-01

    The intracellular systems of detoxification are crucial for the survival of wood degrading fungi. Within these systems, glutathione transferases could play a major role since this family of enzymes is specifically extended in lignolytic fungi. In particular the Ure2p class represents one third of the total GST number in Phanerochaete chrysosporium. These proteins have been phylogenetically split into two subclasses called Ure2pA and Ure2pB. Ure2pB can be classified as Nu GSTs because of shared structural and functional features with previously characterized bacterial isoforms. Ure2pA can rather be qualified as Nu-like GSTs since they exhibit a number of differences. Ure2pA possess a classical transferase activity, a more divergent catalytic site and a higher structural flexibility for some of them, compared to Nu GSTs. The characterization of four members of this Ure2pA subclass (PcUre2pA4, PcUre2pA5, PcUre2pA6 and PcUre2pA8) revealed specific functional and structural features, suggesting that these enzymes have rapidly evolved and differentiated, probably to adapt to the complex chemical environment associated with wood decomposition.

  19. An agent-based incentive mechanism for P2P systems

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jian-feng; WANG Ru-chuan

    2006-01-01

    With the increasing uses of peer-to-peer (P2P)systems, the problems of fair information and resources sharing become serious. P2P systems are self-organizing,distributed systems with no centralized authority, such as Free-riding and Tragedy of Commons. Because of the voluntary participation and lack of motivation, the information and resources available in P2P networks are extremely variable and unpredictable. This article studied the problems existing in P2P networks and propose a different method to stimulate the peers in P2P networks to share information and resources,using agents so as to improve the performance of P2P networks.And through simulation experiments and analyzing the results,it can be concluded that this mechanism can effectively solve the problems of fair sharing in P2P systems.

  20. Effects of the electron correlation and Breit and hyperfine interactions on the lifetime of the 2p$^5$3s states in neutral neon

    CERN Document Server

    Li, Jiguang; Godefroid, Michel; Gaigalas, Gediminas

    2012-01-01

    In the framework of the multiconfiguration Dirac-Hartree-Fock method, we investigate the transition properties of four excited states in the $2p^53s$ configuration of neutral neon. The electron correlation effects are taken into account systematically by using the active space approach. The effect of higher-order correlation on fine structures is shown. We also study the influence of the Breit interaction and find that it reduces the oscillator strength of the $^3P^o_1 - ^1S_0$ transition by 17%. It turns out that the inclusion of the Breit interaction is essential even for such a light atomic system. Our ab initio calculated line strengths, oscillator strengths and transition rates are compared with other theoretical values and experimental measurements. Good agreement is found except for the $^3P^o_2 - ^1S_0$ M2 transition for which discrepancies of around 15% between theories and experiments remain. In addition, the impact of hyperfine interactions on the lifetimes of the $^3P^o_0$ and $^3P^o_2$ metastable...

  1. Relativistic CI calculations of spectroscopic data for the 2p6 and 2p53l configurations in Ne-like ions between Mg III and Kr XXVII

    International Nuclear Information System (INIS)

    Energies, E1, M1, E2, M2 transition rates, oscillator strengths, and lifetimes from relativistic configuration interaction calculations are reported for the states of the 2p6, 2p53s, 2p53p, and 2p53d, configurations in all Ne-like ions between Mg III and Kr XXVII. Core–valence and core–core correlation effects are accounted for through single and double excitations to increasing sets of active orbitals. The Breit interaction and leading quantum electrodynamic effects are included as perturbations. The results are compared with experiments and other recent benchmark calculations. In Mg III, Al IV, Si V, P VI, S VII, and Ar IX, for which experimental energies are known to high accuracy, the mean error in the calculated energies is only 0.011%

  2. Relativistic CI calculations of spectroscopic data for the 2p6 and 2p53l configurations in Ne-like ions between Mg III and Kr XXVII

    International Nuclear Information System (INIS)

    Energies, E1, M1, E2, M2 transition rates, oscillator strengths, and lifetimes from relativistic configuration interaction calculations are reported for the states of the 2p6, 2p53s, 2p53p, and 2p53d, configurations in all Ne-like ions between Mg III and Kr XXVII. Core-valence and core-core correlation effects are accounted for through SD-expansions to increasing sets of active orbitals. The Breit interaction and leading QED effects are included as perturbations. The results are compared with experiments and other recent benchmark calculations. In Mg III, Al IV, Si V, P VI, S VII, and Ar IX, for which experimental energies are known to high accuracy, the mean error in the calculated energies is only 0.011%. (author)

  3. Forbidden 2 P- nP and 2 P- nF transitions in the energy spectrum of ultracold Rydberg lithium-7 atoms

    Science.gov (United States)

    Zelener, B. B.; Saakyan, S. A.; Sautenkov, V. A.; Manykin, E. A.; Zelener, B. V.; Fortov, V. E.

    2016-04-01

    Forbidden 2 P- nP and 2 P- nF transitions in the ranges of the principal quantum number n = 42-114 and n = 38-48 have been detected in the optical spectra of ultracold highly excited lithium-7 atoms. The presence of forbidden transitions is due to induced external electric fields. The quantum defects and ionization energy obtained in various experiments and predicted theoretically have been discussed.

  4. Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1

    Science.gov (United States)

    Cai, Qiuyin; Zhang, Ben; Sung, Hyuna; Low, Siew-Kee; Kweon, Sun-Seog; Lu, Wei; Shi, Jiajun; Long, Jirong; Wen, Wanqing; Choi, Ji-Yeob; Noh, Dong-Young; Shen, Chen-Yang; Matsuo, Keitaro; Teo, Soo-Hwang; Kim, Mi Kyung; Khoo, Ui Soon; Iwasaki, Motoki; Hartman, Mikael; Takahashi, Atsushi; Ashikawa, Kyota; Matsuda, Koichi; Shin, Min-Ho; Park, Min Ho; Zheng, Ying; Xiang, Yong-Bing; Ji, Bu-Tian; Park, Sue K.; Wu, Pei-Ei; Hsiung, Chia-Ni; Ito, Hidemi; Kasuga, Yoshio; Kang, Peter; Mariapun, Shivaani; Ahn, Sei Hyun; Kang, Han Sung; Chan, Kelvin Y. K.; Man, Ellen P. S.; Iwata, Hiroji; Tsugane, Shoichiro; Miao, Hui; Liao, Jiemin; Nakamura, Yusuke; Kubo, Michiaki; Delahanty, Ryan J.; Zhang, Yanfeng; Li, Bingshan; Li, Chun; Gao, Yu-Tang; Shu, Xiao-Ou; Kang, Daehee; Zheng, Wei

    2014-01-01

    In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified three novel genetic loci associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene, P = 8.82 × 10−9), rs10474352 at 5q14.3 (near the ARRDC3 gene, P = 1.67 × 10−9), and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene, P = 4.25 × 10−8). These associations were replicated in European-ancestry populations including 16,003 cases and 41,335 controls (P = 0.030, 0.004, and 0.010, respectively). Data from the ENCODE project suggest that variants rs4951011 and rs10474352 may be located in an enhancer region and transcription factor binding sites, respectively. This study provides additional insights into the genetics and biology of breast cancer. PMID:25038754

  5. 非结构化P2P Overlay拓扑结构分析%Analysis of Topology Structure in Unstructured P2P Overlay

    Institute of Scientific and Technical Information of China (English)

    姜卫; 王观玉; 宋世延

    2010-01-01

    一个合理的P2P overlay可以为P2P应用提供更好的支持.非结构化P2P overlay的构建比较简单随意,适合于信息发布、即时通讯等节点随时加入退出的情况.构建具有可扩展性和稳健性的网络拓扑,是非结构化P2P overlay的研究热点之一.文章首先介绍了几种典型的非结构化P2P overlay,然后与以往研究不同,通过GT-ITM建模分析了每种P2P overlay拓扑结构的性能,主要分析了不同拓扑结构节点的度、最短路径分布、节点发现概率及结构的健壮性等,该工作对构造合理的P2P overlay拓扑结构和P2P系统的研究具有重要意义.

  6. Control of sigma virus multiplication by the ref(2)P gene of Drosophila melanogaster: an in vivo study of the PB1 domain of Ref(2)P.

    Science.gov (United States)

    Carré-Mlouka, A; Gaumer, S; Gay, P; Petitjean, A M; Coulondre, C; Dru, P; Bras, F; Dezélée, S; Contamine, D

    2007-05-01

    Ref(2)P has been described as one of the Drosophila proteins that interacts with the sigma virus cycle. We generated alleles to identify critical residues involved in the restrictive (inhibiting viral multiplication) or permissive (allowing viral multiplication) character of Ref(2)P. We demonstrate that permissive alleles increase the ability of the sigma virus to infect Drosophila when compared to null alleles and we confirm that restrictive alleles decrease this capacity. Moreover, we have created alleles unfunctional in viral cycling while functional for Ref(2)P fly functions. This type of allele had never been observed before and shows that fly- and virus-related activities of Ref(2)P are separable. The viral status of Ref(2)P variants is determined by the amino-terminal PB1 domain polymorphism. In addition, an isolated PB1 domain mimics virus-related functions even if it is similar to a loss of function toward fly-related activities. The evolutionary tree of the Ref(2)P PB1 domain that we could build on the basis of the natural allele sequences is in agreement with an evolution of PB1 domain due to successive transient selection waves.

  7. 伴有5号染色体长臂缺失的急性淋巴细胞白血病一例并文献复习%One case of acute lymphoblastic leukemia with del(5q) and literatures review

    Institute of Scientific and Technical Information of China (English)

    李玉龙; 程薇; 张磊; 张琳; 刘禄社; 翟亚萍

    2012-01-01

    目的 探讨伴有5号染色体长臂缺失(5q-)的急性淋巴细胞白血病的临床及实验室特点.方法 报道1例伴有5q-的急性淋巴细胞白血病,并对相关文献进行复习.结果 患者因腹痛、骨痛就诊.血常规显示白细胞增高、血小板减少.经骨髓穿刺、过氧化物酶染色、流式细胞术免疫分型检测,诊断为急性淋巴细胞白血病(前T细胞型).染色体及荧光免疫杂交检测均发现5q-.应用hyper-CVAD方案化疗曾短暂缓解,复发后应用MEA和hyper-CVAD方案,均无效.通过文献复习发现,5q-在急性淋巴细胞白血病中十分罕见,此类患者5q缺失序列的最小重叠范围位于DNA标记D5S410和D5S436之间,即5q31-33区域.结论 急性淋巴细胞白血病中5q-相当罕见,对该类疾病特点仍需进一步研究.%Objective To introduce the laboratory and clinical characteristics of acute lymphoblastic leukemia accompanied by the karyotypic abnormality of 5q-.Methods Report the diagnosis and treatment of one case of acute lymphoblastic leukemia with 5q- and review the relevant literatures.Results The patient came to the hospital because of bellyache and ostalgia.The blood routine showed a high WBC count and reduced platelets.Bone marrow aspirates examination indicated acute leukemia and by peroxidase staining and flow cytometry test,acute pro-T lymphoblastic leukemia was diagnosed.The karyotype and fluorescence in situ hybridization analysis showed 5q-.The hyper-CVAD regimen induced a temporary remission but it did not work anymore after the relapse nor did the MEA regimen.From the literatures ever reported,the kyryotypic abnormality of 5q- was rarely seen in acute lymphoblastic leukemia.In such cases,the minimal deletion region overlaped between marks of D5S410 and D5S436 corresponding to chromosomal location 5q31-33.Conclusion 5q- is rare in acute lymphoblastic leukemia and more features are still to be found about the kind of disorder.

  8. Photoelectric characteristics of CH3NH3PbI3/p-Si heterojunction

    Science.gov (United States)

    Yamei, Wu; Ruixia, Yang; Hanmin, Tian; Shuai, Chen

    2016-05-01

    Organic–inorganic hybrid perovskite CH3NH3PbI3 film is prepared on p-type silicon substrate using the one-step solution method to form a CH3NH3PbI3/p-Si heterojunction. The film morphology and structure are characterized by atomic force microscopy (AFM) and scanning electron microscopy (SEM). The photoelectric properties of the CH3NH3PbI3/p-Si heterojunction are studied by testing the current–voltage (I–V) with and without illumination and capacitance–voltage (C–V) characteristics. It turns out from the I–V curve without illumination that the CH3NH3PbI3/p-Si heterojunction has a rectifier feature with the rectification ratio over 70 at the bias of ±5 V. Also, there appears a photoelectric conversion phenomenon on this heterojunction with a short circuit current (Isc) of 0.16 μA and an open circuit voltage (Voc) of about 10 mV The high frequency C–V characteristic of the Ag/CH3NH3PbI3/p-Si heterojunction turns out to be similar to that of the metal–insulator–semiconductor (MIS) structure, and a parallel translation of the C–V curve along the forward voltage axis is found. This parallel translation means the existence of defects at the CH3NH3PbI3/p-Si interface and positive fixed charges in the CH3NH3PbI3 layer. The defects at the interface of the CH3NH3PbI3/p-Si heterojunction result in the dramatic decline of the Voc. Besides, the C–V test of CH3NH3PbI3 film shows a non-linear dielectric property and the dielectric value is about 4.64 as calculated. Project supported by the Hebei Province Natural Science Foundation of China (No. F2014202184) and the Tianjin Natural Science Foundation of China (No. 15JCZDJC37800).

  9. The Participative Design of an Endoscopy Facility using Lean 3P.

    Science.gov (United States)

    Smith, Iain

    2016-01-01

    In the UK, bowel cancer is the second largest cancer killer. Diagnosing people earlier can save lives but demand for endoscopies is increasing and this can put pressure on waiting times. To address this challenge, an endoscopy unit in North East England decided to improve their facilities to increase capacity and create environments that improve the experience of users. This presented a significant opportunity for step change improvement but also a problem in terms of creating designs that meet user requirements whilst addressing structural or space constraints. The Lean design process known as '3P' (standing for the production preparation process) was utilised as a participative design strategy to engage stakeholders in the design of the new department. This involved a time-out workshop (or 3P event) in which Lean and participative design tools were utilised to create an innovative design based on 'point of delivery' (POD) principles. The team created a design that demonstrated an increase in treatment room capacity by 25% and bed capacity by 70% whilst reducing travel distance for patients by 25.8% and staff by 27.1%. This was achieved with an increase in available space of only 13%. The Lean 3P method provided a structured approach for corporate and clinical staff to work together with patient representatives as cross-functional teams. This participative approach facilitated communication and learning between stakeholders about care processes and personal preferences. Lean 3P therefore appears to be a promising approach to improving the healthcare facilities design process to meet user requirements.

  10. Temperature dependence and mechanism of the reaction between O(3P) and chlorine dioxide

    Science.gov (United States)

    Colussi, A. J.; Sander, S. P.; Fiedl, R. R.

    1992-01-01

    Second-order rate constants for the decay of O(3P) in excess chlorine dioxide, k(II), were measured as a function of total pressure (20-600 Torr argon) and temperature (248-312 K), using flash photolysis-atomic resonance fluorescence. Results indicate that k(II) is pressure dependent with a value, K(b), that is nonzero at zero pressure, and both the third-order rate constant and k(b) have negative temperature dependences.

  11. LiNbO3/p+n diode surface acoustic wave memory correlator

    Institute of Scientific and Technical Information of China (English)

    张朝; 水永安; 印建华

    1997-01-01

    A detailed theoretical analysis of strip-coupled LiNbO3/p+ n diode surface acoustic wave (SAW) memory correlator in the parametric mode is presented. The influence of some important factors on correlation output is analyzed and calculated, including the amplitudes of reference, read and write signal, duration of write signal and doping density of the diode array. The conclusions can be employed for the design of improved strip-coupled SAW memorycorrelators.

  12. Omega3P: A Parallel Finite-Element Eigenmode Analysis Code for Accelerator Cavities

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Lie-Quan; Li, Zenghai; Ng, Cho; Ko, Kwok; /SLAC

    2009-03-04

    Omega3P is a parallel eigenmode calculation code for accelerator cavities in frequency domain analysis using finite-element methods. In this report, we will present detailed finite-element formulations and resulting eigenvalue problems for lossless cavities, cavities with lossy materials, cavities with imperfectly conducting surfaces, and cavities with waveguide coupling. We will discuss the parallel algorithms for solving those eigenvalue problems and demonstrate modeling of accelerator cavities through different examples.

  13. The Participative Design of an Endoscopy Facility using Lean 3P.

    Science.gov (United States)

    Smith, Iain

    2016-01-01

    In the UK, bowel cancer is the second largest cancer killer. Diagnosing people earlier can save lives but demand for endoscopies is increasing and this can put pressure on waiting times. To address this challenge, an endoscopy unit in North East England decided to improve their facilities to increase capacity and create environments that improve the experience of users. This presented a significant opportunity for step change improvement but also a problem in terms of creating designs that meet user requirements whilst addressing structural or space constraints. The Lean design process known as '3P' (standing for the production preparation process) was utilised as a participative design strategy to engage stakeholders in the design of the new department. This involved a time-out workshop (or 3P event) in which Lean and participative design tools were utilised to create an innovative design based on 'point of delivery' (POD) principles. The team created a design that demonstrated an increase in treatment room capacity by 25% and bed capacity by 70% whilst reducing travel distance for patients by 25.8% and staff by 27.1%. This was achieved with an increase in available space of only 13%. The Lean 3P method provided a structured approach for corporate and clinical staff to work together with patient representatives as cross-functional teams. This participative approach facilitated communication and learning between stakeholders about care processes and personal preferences. Lean 3P therefore appears to be a promising approach to improving the healthcare facilities design process to meet user requirements. PMID:27493744

  14. An extremal problem on potentially $K_{p_{1},p_{2},...,p_{t}}$-graphic sequences

    OpenAIRE

    Lai, Chunhui

    2004-01-01

    A sequence $S$ is potentially $K_{p_{1},p_{2},...,p_{t}}$ graphical if it has a realization containing a $K_{p_{1},p_{2},...,p_{t}}$ as a subgraph, where $K_{p_{1},p_{2},...,p_{t}}$ is a complete t-partite graph with partition sizes $p_{1},p_{2},...,p_{t} (p_{1}\\geq p_{2}\\geq ...\\geq p_{t} \\geq 1)$. Let $\\sigma(K_{p_{1},p_{2},...,p_{t}}, n)$ denote the smallest degree sum such that every $n$-term graphical sequence $S$ with $\\sigma(S)\\geq \\sigma(K_{p_{1},p_{2},...,p_{t}}, n)$ is potentially $...

  15. miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesis.

    Science.gov (United States)

    Sonda, Nada; Simonato, Francesca; Peranzoni, Elisa; Calì, Bianca; Bortoluzzi, Stefania; Bisognin, Andrea; Wang, Ena; Marincola, Francesco M; Naldini, Luigi; Gentner, Bernhard; Trautwein, Christian; Sackett, Sara Dutton; Zanovello, Paola; Molon, Barbara; Bronte, Vincenzo

    2013-06-27

    Tumor progression is accompanied by an altered myelopoiesis causing the accumulation of immunosuppressive cells. Here, we showed that miR-142-3p downregulation promoted macrophage differentiation and determined the acquisition of their immunosuppressive function in tumor. Tumor-released cytokines signaling through gp130, the common subunit of the interleukin-6 cytokine receptor family, induced the LAP∗ isoform of C/EBPβ transcription factor, promoting macrophage generation. miR-142-3p downregulated gp130 by canonical binding to its messenger RNA (mRNA) 3' UTR and repressed C/EBPβ LAP∗ by noncanonical binding to its 5' mRNA coding sequence. Enforced miR expression impaired macrophage differentiation both in vitro and in vivo. Mice constitutively expressing miR-142-3p in the bone marrow showed a marked increase in survival following immunotherapy with tumor-specific T lymphocytes. By modulating a specific miR in bone marrow precursors, we thus demonstrated the feasibility of altering tumor-induced macrophage differentiation as a potent tool to improve the efficacy of cancer immunotherapy.

  16. Resonant inverse photoemission study of late transition metals at 3p absorption edge

    International Nuclear Information System (INIS)

    Full text: Resonant inverse photoemission spectra (RIPES) of late transition metals (TM) were observed near TM 3p absorption edge. The RIPES spectra of polycrystalline Co, Ni and Cu, as well as single crystal Ni, were observed. Figure 1 shows resonant IPES spectra of polycrystalline Co, Ni and Cu, which were prepared by evaporation. These spectra ware excited by energy above 3p absorption edge (off-resonance). Since a core hole is created by these energies, TM 3d → 3p fluorescence peak is observed in each spectrum at high energy, which is indicated by vertical bars. The main peak just above EF is TM 3d structure, while TM 4sp is observed at 10 ∼ 15 eV. In resonant spectra, the 3d structure changes its intensity, while the 4sp structure does not. In case of Ni metal, satellite structures are also observed at about 2 and 4 eV. From a calculation by Tanaka and Jo, which is based on the Anderson impurity model, the observation of satellite structures suggests the 10 ∼ 20 % 3d8 in ground state The RIPES spectra in this study give us a direct evidence of 3d8 component in Ni metal

  17. Absolute frequency measurement of the magnesium intercombination transition $^1S_0 \\to ^3P_1$

    CERN Document Server

    Friebe, Jan; Riedmann, Matthias; Moldenhauer, Karsten; Mehlstäubler, Tanja; Rehbein, Nils; Lisdat, Christian; Rasel, Ernst M; Ertmer, Wolfgang; Schnatz, Harald; Lipphardt, Burghard; Grosche, Gesine

    2007-01-01

    We report on a frequency measurement of the $(3s^2)^1S_0\\to(3s3p)^3P_1$ clock transition of $^{24}$Mg on a thermal atomic beam. The intercombination transition has been referenced to a portable primary Cs frequency standard with the help of a femtosecond fiber laser frequency comb. The achieved uncertainty is $2.5\\times10^{-12}$ which corresponds to an increase in accuracy of six orders of magnitude compared to previous results. The measured frequency value permits the calculation of several other optical transitions from $^1S_0$ to the $^3P_J$-level system for $^{24}$Mg, $^{25}$Mg and $^{26}$Mg. We describe in detail the components of our optical frequency standard like the stabilized spectroscopy laser, the atomic beam apparatus used for Ramsey-Bord\\'e interferometry and the frequency comb generator and discuss the uncertainty contributions to our measurement including the first and second order Doppler effect. An upper limit of $3\\times10^{-13}$ in one second for the short term instability of our optical f...

  18. Study of the Ne(^3P_2) + CH_3F Electron Transfer Reaction below 1 Kelvin

    CERN Document Server

    Jankunas, Justin; Osterwalder, Andreas

    2014-01-01

    Relatively little is known about the dynamics of electron transfer reactions at low collision energy. We present a study of Penning ionization of ground state methyl fluoride molecules by electronically excited neon atoms in the 13 $\\mu$eV--4.8 meV (150 mK--56 K) collision energy range, using a neutral-neutral merged beam setup. Relative cross sections have been measured for three Ne($^3P_2$)+ CH$_3$F reaction channels by counting the number of CH$_3$F$^+$, CH$_2$F$^+$, and CH$_3^+$ product ions, as a function of relative velocity between the neon and methyl fluoride molecular beams. Experimental cross sections markedly deviate from the Langevin capture model at collision energies above 20 K. The branching ratios are constant. In other words, the chemical shape of the CH$_3$F molecule, as seen by Ne($^3P_2$) atom, appears not to change as the collision energy is varied, in contrast to related Ne($^3P_J$) + CH$_3$X (X=Cl and Br) reactions at higher collision energies.

  19. Analysis and Design of Instant Message System Based on P2P

    Institute of Scientific and Technical Information of China (English)

    Shen Zhiwei; Ma Shaowu

    2008-01-01

    By analyzing current development conditions of mainstream Instant Message technologies and services, some detailed discussion about technical solution and formal operation deployment strategies of P2P Instant Message Services based on Interact is made. Several crucial problems of P2P Instant Message System about services management, interconnection with other instant message, security and profit-making mode are analyzed,, and how to develop P2P IM Services is proposed.

  20. Implementing a Secure Key Issuing Scheme for Communication in P2P Networks

    OpenAIRE

    Mohammed Azharuddin; Annapurna P Patil

    2012-01-01

    Key issuing scheme focuses on the confidentiality maintained in using the secret key for communicationin p2p networks. Identity based cryptography (IBC) was introduced into peer-to-peer (P2P) networks recently for identity verification and authentication purposes. However, current IBC-based solutions were not addressing the problem of secure private key issuing. In this paper we propose a novel secure key issuing scheme for P2P networks using IBC. We present an IBC infrastructure setup phase...

  1. In vitro phosphorylation and acetylation of the murine pocket protein Rb2/p130.

    Directory of Open Access Journals (Sweden)

    Muhammad Saeed

    Full Text Available The retinoblastoma protein (pRb and the related proteins Rb2/p130 and 107 represent the "pocket protein" family of cell cycle regulators. A key function of these proteins is the cell cycle dependent modulation of E2F-regulated genes. The biological activity of these proteins is controlled by acetylation and phosphorylation in a cell cycle dependent manner. In this study we attempted to investigate the interdependence of acetylation and phosphorylation of Rb2/p130 in vitro. After having identified the acetyltransferase p300 among several acetyltransferases to be associated with Rb2/p130 during S-phase in NIH3T3 cells in vivo, we used this enzyme and the CDK4 protein kinase for in vitro modification of a variety of full length Rb2/p130 and truncated versions with mutations in the acetylatable lysine residues 1079, 128 and 130. Mutation of these residues results in the complete loss of Rb2/p130 acetylation. Replacement of lysines by arginines strongly inhibits phosphorylation of Rb2/p130 by CDK4; the inhibitory effect of replacement by glutamines is less pronounced. Preacetylation of Rb2/p130 strongly enhances CDK4-catalyzed phosphorylation, whereas deacetylation completely abolishes in vitro phosphorylation. In contrast, phosphorylation completely inhibits acetylation of Rb2/p130 by p300. These results suggest a mutual interdependence of modifications in a way that acetylation primes Rb2/p130 for phosphorylation and only dephosphorylated Rb2/p130 can be subject to acetylation. Human papillomavirus 16-E7 protein, which increases acetylation of Rb2/p130 by p300 strongly reduces phosphorylation of this protein by CDK4. This suggests that the balance between phosphorylation and acetylation of Rb2/p130 is essential for its biological function in cell cycle control.

  2. Survey of Search and Replication Schemes in Unstructured P2P Networks

    CERN Document Server

    Thampi, Sabu M

    2010-01-01

    P2P computing lifts taxing issues in various areas of computer science. The largely used decentralized unstructured P2P systems are ad hoc in nature and present a number of research challenges. In this paper, we provide a comprehensive theoretical survey of various state-of-the-art search and replication schemes in unstructured P2P networks for file-sharing applications. The classifications of search and replication techniques and their advantages and disadvantages are briefly explained. Finally, the various issues on searching and replication for unstructured P2P networks are discussed.

  3. Suppression of Zeeman Relaxation in Cold Collisions of \\(^2P_{1/2}\\) Atoms

    OpenAIRE

    Tscherbul, T.V.; Buchachenko, A. A.; Dalgarno, Alexander; Lu, M.-J.; Weinstein, J. D.

    2009-01-01

    We present a combined experimental and theoretical study of angular momentum depolarization in cold collisions of \\(^2P\\) atoms in the presence of an external magnetic field. We show that collision-induced Zeeman relaxation of Ga\\(^2P_{1/2}\\) and In \\(^2P_{1/2}\\) atoms in cold \\(^4\\)He gas is dramatically suppressed compared to atoms in \\(^2P_{3/2}\\) states. Using rigorous quantum-scattering calculations based on ab initio interaction potentials, we demonstrate that Zeeman transitions in coll...

  4. Sla2p Is Associated with the Yeast Cortical Actin Cytoskeleton via Redundant Localization Signals

    OpenAIRE

    Yang, Shirley; Cope, M. Jamie T.V.; Drubin, David G.

    1999-01-01

    Sla2p, also known as End4p and Mop2p, is the founding member of a widely conserved family of actin-binding proteins, a distinguishing feature of which is a C-terminal region homologous to the C terminus of talin. These proteins may function in actin cytoskeleton-mediated plasma membrane remodeling. A human homologue of Sla2p binds to huntingtin, the protein whose mutation results in Huntington’s disease. Here we establish by immunolocalization that Sla2p is a component of the yeast cortical a...

  5. An Optimized and Improved Network Trust Model Based on P2P

    Directory of Open Access Journals (Sweden)

    Li Wei

    2013-10-01

    Full Text Available Because of the spring up of the P2P network application, its open, anonymous and self-organized characteristics has offered a path for the spreading of virus and junk data, and the security has aroused people’s common concern. The traditional network trust model dealt with dishonest node has certain limitation, for this, improved P2P network trust model and applied D-S evidence theory to the trusted computing of trust model. Through simulation experiment, the result showed: the improved P2P network trust model efficiently increased the successful trading rate of P2P network and improved the network environment

  6. TCLM-P2P: Task Collaboration Logic Model Oriented to P2P Community%TCLM-P2P:面向P2P社区的任务协作逻辑模型

    Institute of Scientific and Technical Information of China (English)

    王杨; 王汝传; 严远亭; 韩志杰; 赵保华

    2012-01-01

    P2P网络中广泛存在的“free riding”现象使其在任务协作领域的应用受到了极大制约.为了实现P2P网络环境下的有效任务协作,提出了一种具有激励机制的任务协作逻辑模型.基于Agent理论,首先给出了对等体、半对等体、P2P社区等概念;然后在合同网的框架下提出了面向P2P网络社区的任务协作逻辑模型TCLM-P2P(task collaborative logic model oriented to P2P community).相对于传统的任务协作模型,在合理的前提假设条件下,模型给出了模型公理和协作规则.该模型通过基于虚拟积分的协作算法实现了具有激励机制的P2P网络中的任务分配与协作.原型系统的实现及仿真实验结果表明TCLM-P2P模型具有可行性和有效性:不仅能够激励自利节点主动参与到任务分配与协作中;同时也能在一定程度上抑制节点的free riding行为,从而保障了P2P系统的有序工作.%Traditional P2P networks mainly are applied to file sharing and instant message fields. However, how to perform the task collaboration based on P2P community is a challenging job. The former research work indicated that the task collaboration in P2P network had been greatly restricted by free riding behaviors. To realize effective task allocating and task collaborating in P2P network environment, this paper presents a task collaboration logic model oriented to P2P community. Based on agent and multi-agent theory, the paper firstly introduces some concepts including the peer body, half-peer body and P2P community; then the TCLM-P2P is presented including some collaboration axioms and rulers. In order to enhance the incentive mechanism, virtual score becomes the main goal which each peer endeavor pursues. In addition, based on the contract net protocol, a task collaboration algorithm is presented. The proposed algorithm is composed of two phases. One is the task collaboration and the other is the task second bid when some peers fail

  7. miR-342-3p affects hepatocellular carcinoma cell proliferation via regulating NF-κB pathway

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Liang; Zhang, Yubao, E-mail: zhyb880077@sina.com

    2015-02-13

    Recent research indicates that non-coding microRNAs (miRNAs) help regulate basic cellular processes in many types of cancer cells. We hypothesized that overexpression of miR-342-3p might affect proliferation of hepatocellular carcinoma (HCC) cells. After confirming overexpression of miR-342-3p with qRT-PCR, MTT assay showed that HCC cell proliferation was significantly inhibited by miR-342-3p, and that it significantly decreased BrdU-positive cell proliferation by nearly sixfold. Searching for targets using three algorithms we found that miR-342-3p is related to the NF-κB pathway and luciferase assay found that IKK-γ, TAB2 and TAB3 are miR-342-3p target genes. Results of western blot on extracted nuclear proteins of HepG2 and HCT-116 cells showed that miR-342-3p reduced and miR-342-3p-in increased p65 nuclear levels and qRT-PCR found that NF-κB pathway downstream genes were downregulated by miR-342-3p and upregulated by miR-342-3p-in, confirming that miR-342 targets NF-κB pathway. Overexpression of Ikk-γ, TAB2 and TAB3 partially rescued HCC cells proliferation inhibited by miR-342-3p. Using the GSE54751 database we evaluated expression from 10 HCC samples, which strongly suggested downregulation of miR-342-3p and we also found inverse expression between miR-342-3p and its targets IKK-γ, TAB2 and TAB3 from 71 HCC samples. Our results show that miR-342-3p has a significant role in HCC cell proliferation and is suitable for investigation of therapeutic targets. - Highlights: • MiR-342-3p suppresses hepatocellular carcinoma cell proliferation. • MiR-342-3p targets IKK-γ, TAB2 and TAB3 genes. • MiR-342-3p downregulates NF-kB signaling pathway. • MiR-342-3p is downregulated in clinical hepatocellular carcinoma samples. • The expression of miR-342-3p and its target gene is inversely related.

  8. Institute of Information Network Technology%P2P-SIP融合及P2P-SIP系统设计

    Institute of Scientific and Technical Information of China (English)

    吴亮

    2010-01-01

    随着现代通信技术的不断发展,P2P(对等网络)技术与SIP(会话初始化协议)之间相互融合成为当前研究的一个热点.文章首先介绍了P2P技术和SIP协议,随后研究怎样将P2P架构与SIP系统进行融合,重点讨论了P2P-SIP的实现过程,包括P2P-SIP终端如何使用SIP协议携带P2P消息实现节点的发现、加入、离开和用户注册等过程.

  9. Deactivation of Ni2P/SiO2 catalyst in hydrodechlorination of chlorobenzene

    International Nuclear Information System (INIS)

    Highlights: • Ni2P/SiO2 has higher performance than Ni/SiO2 for hydrodechlorination. • Ni2P has higher resistance to HCl poison and to sintering than Ni. • Ni2P/SiO2 deactivation is mainly attributed to carbonaceous deposit. • Ni/SiO2 deactivation is mostly due to HCl poison and Ni sintering. - Abstract: The deactivation of the Ni2P/SiO2 catalyst in the hydrodechlorination of chlorobenzene was studied. To better illuminate the reasons for the deactivation, the effect of HCl on the structure and activity of Ni2P/SiO2 was investigated. For comparison, the deactivation of the Ni/SiO2 catalyst was also involved. It was found that the Ni2P particles possessed good resistance to HCl poison and to sintering, which is ascribed to the electron-deficiency of Niδ+(0 < δ < 1) site in Ni2P. Acted as the Lewis and Brönsted acid site, the Niδ+ site and the P-OH group on Ni2P/SiO2 catalyzed the formation of the carbonaceous deposit that was difficultly eliminated by hydrogenation. The carbonaceous deposit covered the active sites and might also induce a decrease in the Ni2P crystallinity, subsequently leading to the Ni2P/SiO2 deactivation. Different from Ni2P/SiO2, Ni/SiO2 was mainly deactivated by the chlorine poison and the sintering of nickel crystallites

  10. 基于 SIP 的 P2P VoIP技术研究%Research on P2 P VoIP Technology Based on SIP

    Institute of Scientific and Technical Information of China (English)

    杜经纬

    2015-01-01

    随着三网融合的推进,将会给VoIP带来广阔的发展空间。针对目前常用的VoIP系统存在的网络开销高、呼叫接通率低、信令过于复杂等问题,在对SIP协议在P2P网络环境下实现VoIP的关键技术进行认真分析的基础上,提出了基于SIP的P2P VoIP。通过给出基于SIP的P2P VoIP的基本体系结构,分析了该系统中对等点的发现、用户注册及离线、呼叫建立等功能的实现方法,最后提出了基于SIP的P2P VoIP系统还应该考虑的一些问题。%With the progress in the convergence of the telecommunication, internet and broadcasting networks, VoIP will be presented with broad space for development.However, existing VoIP systems usually suffer from high network overhead, low call completing rate, complex signaling, etc.To solve these problems, this paper, based on a thorough analysis of key technologists involved in VoIP using SIP protocol in the P2P network scenario, proposed the SIP-based P2P VoIP system.By introducing the basic architecture of the SIP-based P2P VoIP system, this paper also analyzes the implementation of functions including peer discovery, user registration and getting offline and call establishment, and points out some questions that should be considered in this system.

  11. Data of evolutionary structure change: 1BFGA-2P23A [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1BFGA-2P23A 1BFG 2P23 A A ---DPKRLYC-KNGG---FFLRIHPDGRVDGVREKSDPH.../confEVID> 0 1BFG A 1BFG...dex> 1BFG A 1BFGA GS...4 HIS CA 324 SER CA 410 LEU CA 389 1BFG... A 1BFGA GVREKSDPHIK

  12. HFBP: Identifying P2P Traffic by Host Level and Flow Level Behavior Profiles

    Directory of Open Access Journals (Sweden)

    Jinghua Yan

    2013-08-01

    Full Text Available Recently, Peer-to-peer (P2P networks have been widely applied in streaming media, instant messaging, file sharing and other fields, which have occupied more and more network bandwidth. Accurately identify P2P traffic is very important to management and control P2P traffic. In this paper, we introduce HFBP, a novel P2P identification scheme based on the host level and flow level behavior profiles of P2P traffic. HFBP consists of two stages. In the first stage, we calculate the probability that a host takes part in P2P application by matching its behavior with some host level behavior rules. In the second stage, we compute the probability that a flow belonging to P2P application by comparing the statistical features of each flow in the host with several flow feature profiles. We evaluate HFBP using real traffic traces. The identification accuracy achieves 93.1% and 95.1% in terms of flow and byte respectively. The experimental results prove that HFBP obtains satisfactory performance in identifying P2P traffic. 

  13. P2P XQuery and the StreetTiVo application

    NARCIS (Netherlands)

    Boncz, P.A.; Zhang, Y.

    2007-01-01

    In the AmbientDB project, we are building MonetDB/XQuery, an open-source XML DBMS (XDBMS) with support for distributed querying and P2P services. Our work is motivated by the hypothesis that P2P is a disruptive paradigm that should change the nature of database technology. Most of the existing distr

  14. A Study of Perkins 2P1 Graduation Performance Rates at Virginia Western Community College

    Science.gov (United States)

    Archer, J. Andrew.

    2006-01-01

    "2P1" is the Carl Perkins label for an institution's graduation performance rate. Systems receiving Perkins funds, like Virginia's 23 community colleges, are expected to meet a federally approved 2P1 target rate. For the 3-year period 1999-2001 Virginia Western Community College (VWCC) was one of seven community colleges in the VCCS (Virginia…

  15. SAPIR - Executing complex similarity queries over multi layer P2P search structures

    OpenAIRE

    Falchi, Fabrizio; Batko, Michal

    2009-01-01

    This deliverable reports the activities conducted within Task 5.4 "Executing complex similarity queries over multi layer P2P search structures" of the SAPIR project. In particular the deliverable discusses complex similarity queries issues and the implementation of the query processing over the P2P indexing. The document is accompanied by a zip file containing the javadoc for MUFIN.

  16. Peer-to-Peer (P2P) Knowledge, Use, and Attitudes of Academic Librarians

    Science.gov (United States)

    Hendrix, Dean

    2007-01-01

    To assess their knowledge, use, and attitudes regarding peer-to-peer (P2P) applications, this study surveyed academic librarians (n = 162) via a mail-in survey. Correlations between the sample characteristics (age, gender, year of MLS, type of library job) and P2P knowledge, use, and attitudes were also explored. Overall, academic librarians…

  17. 2p3d Resonant X-ray emission spectroscopy of cobalt compounds

    NARCIS (Netherlands)

    van Schooneveld, M.M.

    2013-01-01

    This manuscript demonstrates that 2p3d resonant X-ray emission spectroscopy (RXES) yields unique information on the chemically relevant valence electrons of transition metal atoms or ions. Experimental data on cobalt compounds and several theories were used hand-in-hand. In chapter 1 2p3d RXES was s

  18. PD2P : PanDA Dynamic Data Placement for ATLAS

    CERN Document Server

    CERN. Geneva

    2012-01-01

    The PanDA Dynamic Data Placement (PD2P) system has been developed to cope with difficulties of data placement for ATLAS. PD2P is an intelligent subsystem of PanDA to distribute data by taking the following factors into account: popularity, locality, the usage pattern of the data, the distribution of CPU and storage resources, ...

  19. Quantum chaos in ultracold collisions between Yb($^1$S$_0$) and Yb($^3$P$_2$)

    CERN Document Server

    Green, Dermot G; Frye, Matthew D; Morita, Masato; Hutson, Jeremy M

    2015-01-01

    We calculate and analyze Feshbach resonance spectra for ultracold Yb($^1$S$_0$) + Yb($^3$P$_2$) collisions as a function of an interatomic potential scaling factor $\\lambda$ and external magnetic field. We show that, at zero field, the resonances are distributed randomly in $\\lambda$, but that signatures of quantum chaos emerge as a field is applied. The random zero-field distribution arises from superposition of structured spectra associated with individual total angular momenta. In addition, we show that the resonances in magnetic field in the experimentally accessible range 400 to 2000~G are chaotically distributed, with strong level repulsion that is characteristic of quantum chaos.

  20. A quasi-particle description of the M(3,p) models

    OpenAIRE

    Jacob, P.; Mathieu, P

    2005-01-01

    The M(3,p) minimal models are reconsidered from the point of view of the extended algebra whose generators are the energy-momentum tensor and the primary field \\phi_{2,1} of dimension $(p-2)/4$. Within this framework, we provide a quasi-particle description of these models, in which all states are expressed solely in terms of the \\phi_{2,1}-modes. More precisely, we show that all the states can be written in terms of \\phi_{2,1}-type highest-weight states and their phi_{2,1}-descendants. We fu...

  1. Absolute frequency measurement of the 1S0 - 3P0 transition of 171Yb

    CERN Document Server

    Pizzocaro, Marco; Rauf, Benjamin; Bregolin, Filippo; Milani, Gianmaria; Clivati, Cecilia; Costanzo, Giovanni A; Levi, Filippo; Calonico, Davide

    2016-01-01

    We report the absolute frequency measurement of the unperturbed transition 1S0 - 3P0 at 578 nm in 171Yb realized in an optical lattice frequency standard. The absolute frequency is measured 518 295 836 590 863.55(28) Hz relative to a cryogenic caesium fountain with a fractional uncertainty of 5.4x10-16 . This value is in agreement with the ytterbium frequency recommended as a secondary representation of the second in the International System of Units.

  2. Electron-phonon superconductivity in $A$Pt$_3$P compounds: from weak to strong coupling

    OpenAIRE

    Subedi, Alaska; Ortenzi, Luciano; Boeri, Lilia

    2012-01-01

    We study the newly discovered Pt phosphides $A$Pt$_3$P ($A$=Sr, Ca, La) [ T. Takayama et al. Phys. Rev. Lett. 108, 237001 (2012)] using first-principles calculations and Migdal-Eliashberg theory. Given the remarkable agreement with the experiment, we exclude the charge-density wave scenario proposed by previous first-principles calculations, and give conclusive answers concerning the superconducting state in these materials. The pairing increases from La to Ca and Sr due to changes in the ele...

  3. Phase transitions in Cd3P2 at high pressures and high temperatures

    DEFF Research Database (Denmark)

    Yel'kin, F.S.; Sidorov, V.A.; Waskowska, A.;

    2008-01-01

    The high-pressure, high-temperature structural behaviour of Cd3P2 has been studied using electrical resistance measurements, differential thermal analysis, thermo baric analysis and X-ray diffraction. At room temperature, a phase transformation is observed at 4.0 GPa in compression....... The experimental zero-pressure bulk modulus of the low-pressure phase is 64.7(7) GPa, which agrees quite well with the calculated value of 66.3 GPa using the tight-binding linear muffin-tin orbital method within the local density approximation. Tentatively, the high-pressure phase has an orthorhombic crystal...

  4. Pulsar Spin-Down by 3P2 Superfluid Neutron with Field Decay

    Institute of Scientific and Technical Information of China (English)

    LUO Xin-Lian; PENG Qiu-He; CHOU Chih-Kang

    2003-01-01

    To describe pulsar spin-down, we present a simple combined torque model that takes into account both the standard magnetic dipole radiation and the electromagnetic radiation from the 3P2 superSuid vortex neutrons inside neutron star. Using an ordinary exponential model for the magnetic field decay, we derive an analytical formulae for pulsar evolution tracks. The pulsar evolution on the P-P diagram is quite different from that of the standard magnetic dipole radiation model, especially when the supernuid torque or Geld decay becomes dominant.

  5. SPF-A*: Searching Multimedia Data in Heterogeneous Mobile P2P Network

    Directory of Open Access Journals (Sweden)

    Fan Ye

    2009-04-01

    Full Text Available Mobile P2P (MP2P network has been widely used in everyday life combined with the wireless technology development. However, most previous works concentrate on the assumption that the mobile peers are identical of their inner properties in compositing a MP2P network. However, in current network environment, heterogeneous devices are widely used; they may have different storage sizes, data transmission rate, processing ability and even security levels. In such kind of MP2P Network environment, how to make data transmission effectively is challenge. In this paper, we concentrate on how to effectively obtain a queried multimedia resource and generate a path for such data transmission on the overlay MP2P network, so as to make the resource more effectively transmit among the heterogeneous peers. A new path generating algorithm called SPF-A* (Super Peer First A* is devised, and simulation studies are conducted to validate our proposal.

  6. A Trust Scheme Based DRM Model for P2P System

    Institute of Scientific and Technical Information of China (English)

    XIAO Shangqin; LU Zhengding; LING Hefei; ZOU Fuhao

    2006-01-01

    With the maturation of P2P technology, there are more and more challenges to the protection of digital rights.DRM for traditional Client/Server model can not satisfy the requirement of digital right protection of P2P network.With practical application of P2P network technology and new generational DRM technology, the article proposes a DRM model for P2P system based on trust degree.The proposed model shares the secret key to the trusty peers and affords necessary security ensure for digital content delivery based on P2P technology.Mathematic analyses and simulations show that, compared to the current DRM model, the proposed model is more robust toleration of transmit and security.

  7. A Free-Rider Forecasting Model Based on Gray System Theory in P2P Networks

    Directory of Open Access Journals (Sweden)

    He Xu

    2012-11-01

    Full Text Available The aim of this study is to forecast the number of free-riders in P2P networks which can help network managers to know the status of the networks in advance and take appropriate measures to cope with free-riding behavior. Free-riding behavior is common in P2P networks, which has a negative impact on the robustness, availability and stability of the networks. Severe free-riding behavior may lead to the crash of the whole P2P application system. Based on the research of free-riding behavior in P2P networks, this paper constructs a free-rider forecasting model (GST model using Gray System Theory. Simulation experiments show that this model has high feasibility, and can carry out reasonable predictions on the number of free-riders in P2P networks.

  8. Computing and Routing for Trust in Structured P2P Network

    Directory of Open Access Journals (Sweden)

    Biao Cai

    2009-09-01

    Full Text Available Study of trust in P2P network now is focus on how to effectively against various malicious behaviors such as providing fake or misleading feedback about other peers and the management of trust in a P2P environment. But the scotoma of portability that trust peer can join (leave a certain P2P network at anytime and anywhere is seldom discussed. In this paper, a structured topology for trusts management in portable P2P network based on DHT (discrete hash table is proposed first, in which includes trust management strategies and peer operations on certain DHT circle. After that, a novel trust-computing model for the structured P2P network and the main trust decisions in the structured network are introduced too. Effectiveness and practicality of the proposed trust management have been showed in simulation experiments at the end.

  9. Research on P2P Overlay Network Model with Small-world Features

    Directory of Open Access Journals (Sweden)

    Hao LIU

    2013-09-01

    Full Text Available Topology structure of P2P network decides its system performance. However, the existing P2P network models don’t take clustering and symmetry of nodes into account. Based on the algebra and graph theory method of Cayley graph, this paper proposes a novel P2P overlay network model with small-world features. Its simplicity and symmetry can ensure the self-organization and scalability of P2P network. The results of analysis and experiment shows that this model provides better robustness, higher enquiry efficiency and better load balance than the existing P2P Overlay Network models such as Chord and CAN. Furthermore, it possesses the property of high clustering.

  10. Convergence of Internet and TV: The Commercial Viability of P2P Content Delivery

    Science.gov (United States)

    de Boever, Jorn

    The popularity of (illegal) P2P (peer-to-peer) file sharing has a disruptive impact on Internet traffic and business models of content providers. In addition, several studies have found an increasing demand for bandwidth consuming content, such as video, on the Internet. Although P2P systems have been put forward as a scalable and inexpensive model to deliver such content, there has been relatively little economic analysis of the potentials and obstacles of P2P systems as a legal and commercial content distribution model. Many content providers encounter uncertainties regarding the adoption or rejection of P2P networks to spread content over the Internet. The recent launch of several commercial, legal P2P content distribution platforms increases the importance of an integrated analysis of the Strengths, Weaknesses, Opportunities and Threats (SWOT).

  11. Duplicación 5q34q35.3 que involucra el gen NSD1: región delimitada por microarreglos de hibridación genómica comparativa. A propósito de un caso

    Directory of Open Access Journals (Sweden)

    AR Vázquez del Campo

    2016-09-01

    Full Text Available La duplicación de la región 5q34q35.3 se ha asociado a un fenotipo inverso de síndrome de Sotos, por contener el gen NSD1 en doble dosis. Se presenta a una paciente con retraso global del desarrollo, peso y talla bajos y dismorfias. Cuenta con antecedente de corrección quirúrgica por defectos de septación auriculoventricular (CIA y CIV, así como remodelación por antecedente de cráneo en trébol. El cariotipo con bandas G mostró un resultado 46,XX,add(5(q35, y para confirmar el origen del material adicional se utilizó sonda de FISH WCP para el cromosoma 5 [46,XX,add(5(q35.ish dup(5(q35(wcp5+]. Para definir puntos de ruptura y realizar correlación genotipo fenotipo se realizó microarreglo CytoScan HD de Affymetrix, que confirmó la duplicación intersticial de novo de 14Mb 46,XX,add(5(q35. arr[hg19] 5q34q35.3(163,110,984-177,227,216x3,177,259,401- 179,330,764x3,179,346,465 180,719,789x3dn, que contiene 80 genes (USCS genome browser, NCBI36/hg19. La descripción de este caso es importante para complementar la delineación del fenotipo, mediante la correlación con la región de la duplicación a nivel de nucleótidos. Cabe resaltar que la paciente demuestra la importancia y la utilidad de las nuevas técnicas de citogenética molecular, con las cuales es posible el análisis detallado de los genes localizados en la región 5q involucrada, así como su correlación con las manifestaciones clínicas.

  12. A New Case of an Extremely Rare 3p21.31 Interstitial Deletion.

    Science.gov (United States)

    Lovrecic, Luca; Bertok, Sara; Žerjav Tanšek, Mojca

    2016-05-01

    Interstitial 3p21.31 deletions have been very rarely reported. We describe a 7-year-old boy with global developmental delay, specific facial characteristics, hydronephrosis, and hypothyreosis with a de novo deletion of 3p21.31, encompassing 29 OMIM genes. Despite the wide use of microarrays, no similar case has been reported in the literature so far. Five overlapping cases are deposited in the DECIPHER database, 2 of which have significant overlapping chromosomal aberrations. They both share some phenotypic characteristics with our case, e.g. developmental delay, intellectual disability and facial dysmorphism (arched eyebrows, hypertelorism, low-set ears, and a large nose tip). In addition, loss-of-function mutations in the SETD2 gene (OMIM 612778) of the deleted region have been described in 3 patients, presenting with some similar clinical features, namely overgrowth, intellectual disability, speech delay, hypotonia, autism, and epilepsy. Therefore, SETD2 may explain part of the phenotype in our case. We focused on 3 other genes in the deleted region, based on their known functions, namely CSPG5 (OMIM 606775), PTH1R (OMIM 168468) and SMARCC1 (OMIM 601732), and assessed their potentially important role in describing the patient's phenotype. Additional cases with haploinsufficiency of this region are needed to elucidate further genotype-phenotype correlations. PMID:27385966

  13. Metalloid tolerance based on phytochelatins is not functionally equivalent to the arsenite transporter Acr3p.

    Science.gov (United States)

    Wysocki, Robert; Clemens, Stephan; Augustyniak, Daria; Golik, Pawel; Maciaszczyk, Ewa; Tamás, Markus J; Dziadkowiec, Dorota

    2003-05-01

    Active transport of metalloids by Acr3p and Ycf1p in Saccharomyces cerevisiae and chelation by phytochelatins in Schizosaccharomyces pombe, nematodes, and plants represent distinct strategies of metalloid detoxification. In this report, we present results of functional comparison of both resistance mechanisms. The S. pombe and wheat phytochelatin synthase (PCS) genes, when expressed in S. cerevisiae, mediate only modest resistance to arsenite and thus cannot functionally compensate for Acr3p. On the other hand, we show for the first time that phytochelatins also contribute to antimony tolerance as PCS fully complement antimonite sensitivity of ycf1Delta mutant. Remarkably, heterologous expression of PCS sensitizes S. cerevisiae to arsenate, while ACR3 confers much higher arsenic resistance in pcsDelta than in wild-type S. pombe. The analysis of PCS and ACR3 homologues distribution in various organisms and our experimental data suggest that separation of ACR3 and PCS genes may lead to the optimal tolerance status of the cell.

  14. MiR-519d-3p suppresses invasion and migration of trophoblast cells via targeting MMP-2.

    Directory of Open Access Journals (Sweden)

    Jie Ding

    Full Text Available Our study was approved by the Medical Ethics Committee of Tang Du Hospital, Fourth Military Medical University and complied strictly with national ethical guidelines. Preeclampsia (PE is a specific clinical disorder characterized by gestational hypertension and proteinuria and is a leading cause of maternal and perinatal mortality worldwide. The miR-519d-3p is upregulated in the maternal plasma of patients with PE which indicates a possible association between this microRNA and the pathogenesis of PE. No studies to date have addressed the effect of miR-519d-3p on the invasion and migration of trophoblast cells. In our study, we found that miR-519d-3p expression was elevated in placental samples from patients with PE. In vitro, overexpression of miR-519d-3p significantly inhibited trophoblast cell migration and invasion, whereas transfection of a miR-519d-3p inhibitor enhanced trophoblast cell migration and invasion. Luciferase assays confirmed that matrix metalloproteinase-2 (MMP-2 is a direct target of miR-519d-3p. Quantitative real-time PCR and western blot assays showed that overexpression of miR-519d-3p downregulated MMP-2 mRNA and protein expression. Knockdown of MMP-2 using a siRNA attenuated the increased trophoblast migration and invasion promoted by the miR-519d-3p inhibitor. In placentas from patients with PE or normal pregnancies, a negative correlation between the expression of MMP-2 and miR-519d-3p was observed using the Pearson correlation and linear regression analysis. Our present findings suggest that upregulation of miR-519d-3p may contribute to the development of PE by inhibiting trophoblast cell migration and invasion via targeting MMP-2; miR-519d-3p may represent a potential predictive and therapeutic target for PE.

  15. Automated Simulation P2P Botnets Signature Detection by Rule-based Approach

    Directory of Open Access Journals (Sweden)

    Raihana Syahirah Abdullah

    2016-08-01

    Full Text Available Internet is a most salient services in communication. Thus, companies take this opportunity by putting critical resources online for effective business organization. This has given rise to activities of cyber criminals actuated by botnets. P2P networks had gained popularity through distributed applications such as file-sharing, web caching and network storage whereby it is not easy to guarantee that the file exchanged not the malicious in non-centralized authority of P2P networks. For this reason, these networks become the suitable venue for malicious software to spread. It is straightforward for attackers to target the vulnerable hosts in existing P2P networks as bot candidates and build their zombie army. They can be used to compromise a host and make it become a P2P bot. In order to detect these botnets, a complete flow analysis is necessary. In this paper, we proposed an automated P2P botnets through rule-based detection approach which currently focuses on P2P signature illumination. We consider both of synchronisation within a botnets and the malicious behaviour each bot exhibits at the host or network level to recognize the signature and activities in P2P botnets traffic. The rule-based approach have high detection accuracy and low false positive.

  16. Bandwidth Reduction via Localized Peer-to-Peer (P2P Video

    Directory of Open Access Journals (Sweden)

    Ken Kerpez

    2010-01-01

    Full Text Available This paper presents recent research into P2P distribution of video that can be highly localized, preferably sharing content among users on the same access network and Central Office (CO. Models of video demand and localized P2P serving areas are presented. Detailed simulations of passive optical networks (PON are run, and these generate statistics of P2P video localization. Next-Generation PON (NG-PON is shown to fully enable P2P video localization, but the lower rates of Gigabit-PON (GPON restrict performance. Results here show that nearly all of the traffic volume of unicast video could be delivered via localized P2P. Strong growth in video delivery via localized P2P could lower overall future aggregation and core network bandwidth of IP video traffic by 58.2%, and total consumer Internet traffic by 43.5%. This assumes aggressive adoption of technologies and business practices that enable highly localized P2P video.

  17. Cloning, sequence analysis and radiation hybrid mapping of a mammalian KRT2p gene.

    Science.gov (United States)

    Miller, A B; Lowe, J K; Ostrander, E A; Galibert, F; Murphy, K E

    2001-09-01

    We report here on the cloning, characterization and radiation hybrid mapping of the canine basic keratin gene KRT2p. The gene spans 8.3 kb, consists of nine exons and eight introns, and is characterized by the typical features of both basic keratins and keratins in general, including glycine-rich head and tail domains, which flank an alpha-helical rod domain of approximately 310 amino acids. Comparisons of sequence and structure reveal that canine KRT2p is strikingly similar to human KRT2p. Alignment of the predicted amino acid sequences for human and dog reveals greater than 80% identity. In the rod domain, the amino acid identity exceeds 90%. We note, however, that canine KRT2p encodes a protein 21 residues longer than human K2p due to the insertion of a glycine repeat motif, GG(G)X, in the head and tail domains of the canine gene. This is the first report of the nearly complete genome sequence for KRT2p of any organism. Radiation hybrid mapping of canine KRT2p to chromosome 27 of the dog is also reported. PMID:11793249

  18. Solution structure of the ubiquitin-binding domain in Swa2p from Saccharomyces cerevisiae.

    Science.gov (United States)

    Chim, Nicholas; Gall, Walter E; Xiao, Jing; Harris, Mark P; Graham, Todd R; Krezel, Andrzej M

    2004-03-01

    The SWA2/AUX1 gene has been proposed to encode the Saccharomyces cerevisiae ortholog of mammalian auxilin. Swa2p is required for clathrin assembly/dissassembly in vivo, thereby implicating it in intracellular protein and lipid trafficking. While investigating the 287-residue N-terminal region of Swa2p, we found a single stably folded domain between residues 140 and 180. Using binding assays and structural analysis, we established this to be a ubiquitin-associated (UBA) domain, unidentified by bioinformatics of the yeast genome. We determined the solution structure of this Swa2p domain and found a characteristic three-helix UBA fold. Comparisons of structures of known UBA folds reveal that the position of the third helix is quite variable. This helix in Swa2p UBA contains a bulkier tyrosine in place of smaller residues found in other UBAs and cannot pack as close to the second helix. The molecular surface of Swa2p UBA has a mostly negative potential, with a single hydrophobic surface patch found also in the UBA domains of human protein, HHR23A. The presence of a UBA domain implicates Swa2p in novel roles involving ubiquitin and ubiquitinated substrates. We propose that Swa2p is a multifunctional protein capable of recognizing several proteins through its protein-protein recognition domains. PMID:14997574

  19. THash: A Practical Network Optimization Scheme for DHT-based P2P Applications

    OpenAIRE

    Sun, Yi; Yang, Richard; Zhang, Xiaobing; Guo, Yang; Li, Jun; Salamatian, Kavé

    2013-01-01

    International audience P2P platforms have been criticized because of the heavy strain that they can inflict on costly inter-domain links of network operators. It is therefore mandatory to develop network optimization schemes for controlling the load generated by a P2P platform on an operator network. While many research efforts exist on centralized tracker-based systems, in recent years multiple DHT-based P2P platforms have been widely deployed and considered as commercial services due to ...

  20. Molecular physiology of pH-sensitive background K(2P) channels.

    Science.gov (United States)

    Lesage, Florian; Barhanin, Jacques

    2011-12-01

    Background K(2P) channels are tightly regulated by different stimuli including variations of external and internal pH. pH sensitivity relies on proton-sensing residues that influence channel gating and activity. Gene inactivation in the mouse is a revealing implication of K(2P) channels in many physiological functions ranging from hormone secretion to central respiratory adaptation. Surprisingly, only a few phenotypic traits of these mice have yet been directly related to the pH sensitivity of K(2P) channels. PMID:22170960

  1. A Free-Rider Forecasting Model Based on Gray System Theory in P2P Networks

    OpenAIRE

    He Xu; Zhao-xiong Zhou; Suo-ping Wang; Ru-chuan Wang

    2012-01-01

    The aim of this study is to forecast the number of free-riders in P2P networks which can help network managers to know the status of the networks in advance and take appropriate measures to cope with free-riding behavior. Free-riding behavior is common in P2P networks, which has a negative impact on the robustness, availability and stability of the networks. Severe free-riding behavior may lead to the crash of the whole P2P application system. Based on the research of free-riding behavior in ...

  2. Pre-Paid Charging System for Sip-P2P Commercial Applications

    OpenAIRE

    Damian Nowak; Krzysztof Walkowiak

    2011-01-01

    The new SIP-P2P approach brings many advantages like the improved reliability and the ease of setup.However, Communications Service Providers (CSPs) offering VoIP services seem to be afraid to losetheir profits due to the introduction of SIP-P2P. Claimed is the lack of session establishment controlleading to revenue leakages. In this work we introduce a charging system for SIP-P2P that assures CSPs’revenue from using SIP-based peer-to-peer communications commercially. The proposed solutioncon...

  3. P2 P 网络借贷的运营与法律监管%Regulation on Online P2P Lending

    Institute of Scientific and Technical Information of China (English)

    樊云慧

    2014-01-01

    The rapid development of online person -to -person lending poses great challenge to its regula-tion.In the United States ,the current regulatory structure for online P 2 P lending involves multiple overseeing agen-cies including the United States Securities and Exchange Commission , various federal bank regulators , the Consum-er Financial Protection Bureau and the state counterparts of all these entities .Under this system , the protection on lenders mainly depends on the securities regulation .From April 2014, P2P lending came under the regulatory man-date of the Financial Conduct Authority.Our country hasn’t started regulation on online P2P lending.Due to the public interests it involves , the necessity for online P2P lending to prevent risk and develop healthily requires its regulation as soon as possible .The sphere of online P2P lending is similar to financial business , so it should be regulated by financial regulatory agency .Under the current financial regulation system in China ,banking regulatory commission should be the authority to regulate on online P 2P lending.%P2P网络借贷的迅猛发展给监管带来了巨大的挑战。在美国,P2P网络借贷实行由证券监管部门、银行监管部门、金融消费者保护局等多个部门共同监管的分散监管体制,对投资者的保护主要是通过证券监管实现的。英国自2014年4月起将P2P网络借贷纳入金融行为局( FCA)的监管范畴。我国尚未对P2P网络借贷予以监管,但P2P行业因涉及公众利益,出于风险防范和其健康发展的需要,监管问题必须尽快予以解决。由于P2 P借贷公司从事的是类金融业务,故应由监管金融业务的机构予以监管。在我国现行的金融监管体制下,对P2 P网络借贷实行统一监管的机构应为银监会。

  4. CHARACTERIZATION AND CHROMOSOMAL ASSIGNMENT OF YEAST ARTIFICIAL CHROMOSOMES CONTAINING HUMAN 3P13-P21-SPECIFIC SEQUENCE-TAGGED SITES

    NARCIS (Netherlands)

    MICHAELIS, SC; BARDENHEUER, W; LUX, A; SCHRAMM, A; GOCKEL, A; SIEBERT, R; WILLERS, C; SCHMIDTKE, K; TODT, B; VANDERHOUT, AH; BUYS, CHCM; HEPPELLPARTON, AC; RABBITTS, PH; UNGAR, S; SMITH, D; LEPASLIER, D; COHEN, D; OPALKA, B; SCHUTTE, J

    1995-01-01

    Human chromosomal region 3p12-p23 is proposed to harbor at least three tumor suppressor genes involved in the development of lung cancer, renal cell carcinoma, and other neoplasias. In order to identify one of these genes we defined sequence tagged sites (STSs) specific for 3p13-p24.2 by analyzing a

  5. Product lambda-doublet ratios for the O(3P) + D2 reaction: A mechanistic imprint

    CERN Document Server

    Jambrina, P G; Aldegunde, J; Brouard, M; Aoiz, F J

    2016-01-01

    In the last decade, the development of theoretical methods have allowed chemists to reproduce and explain almost all of the experimental data associated with elementary atom plus diatom collisions. However, there are still a few examples where theory cannot account yet for experimental results. This is the case for the preferential population of one of the $\\Lambda$-doublet states produced by chemical reactions. In particular, recent measurements of the OD($^2\\Pi$) product of the O($^3$P) + D$_2$ reaction have shown a clear preference for the $\\Pi(A')$ $\\Lambda$-doublet states, in apparent contradiction with {\\em ab initio} calculations, which predict a larger reactivity on the $A"$ potential energy surface. Here we present a method to calculate the $\\Lambda$-doublet ratio when concurrent potential energy surfaces participate in the reaction. It accounts for the experimental $\\Lambda$-doublet populations via explicit consideration of the stereodynamics of the process. Furthermore, our results demonstrate that...

  6. Mechanisms and Kinetics of Radical Reaction of O(1D,3P) + HCN System

    Institute of Scientific and Technical Information of China (English)

    HUANG Yu-Cheng; DU Jin-Yan; JU Xue-Hai; YE Shi-Yong; ZHOU Tao

    2008-01-01

    The reaction of HCN with O(1D, 3P) radical has been investigated by density functional theory (DFT) and ab initio methods. The stationary points on the reaction paths(reactants, intermediates and products) were optimized at the (U)B3LYP/aug-cc-pVTZ level.Single-point calculations were performed at the (U)QCISD(T)/aug-cc-pVTZ level for the optimized structures and all the total energies were corrected by zero-point energy. It is shown that there exist three competing mechanisms of oxygen attacking nitrogen O→N, oxygen attacking carbon O→C and oxygen attacking hydrogen O→H. The rate constants were obtained via Eyring transition-state theory in the temperature range of 600~2000 K. The linear relationship between lnk and 1/T was presented. The results show that path 1 is the main reaction channel and the product of NCO + H is predominant.

  7. High strength Al–Al2O3p composites: Optimization of extrusion parameters

    DEFF Research Database (Denmark)

    Luan, B.F.; Hansen, Niels; Godfrey, A.;

    2011-01-01

    Composite aluminium alloys reinforced with Al2O3p particles have been produced by squeeze casting followed by hot extrusion and a precipitation hardening treatment. Good mechanical properties can be achieved, and in this paper we describe an optimization of the key processing parameters. The...... investigation of their mechanical properties and microstructure, as well as on the surface quality of the extruded samples. The evaluation shows that material with good strength, though with limited ductility, can be reliably obtained using a production route of squeeze casting, followed by hot extrusion and a...... precipitation hardening treatment. For the extrusion step optimized processing parameters have been determined as: (i) extrusion temperature=500°C–560°C; (ii) extrusion rate=5mm/s; (iii) extrusion ratio=10:1....

  8. Theoretical study of stereodynamics for reaction O(3P)+HCl

    Science.gov (United States)

    Zhu, Tong; Hu, Guo-Dong; Chen, Jian-Zhong; Liu, Xin-Guo; Zhang, Qing-Gang

    2010-08-01

    The vector correlation between products and reagents for reaction O(3P)+HCl→OH+Cl is studied using a quasi-classical trajectory (QCT) method on the benchmark potential energy surface of the ground 3A″ state [Ramachandran and Peterson, J. Chem. Phys. 119 (2003) 9550]. The generalised differential cross section (2π/σ)(dσ00/dωt) is presented in the centre of mass frame. The distribution of dihedral angles, P(phir), and the distribution of angles between k and j', P(θr), are calculated. The influence of the collision energy and the influence of the reagent rotation and vibration on the product polarization are studied in the present work. The calculated results indicate that the rotational polarization of the product molecule is almost independent of collision energy but sensitive to the reagent rotation and vibration.

  9. Superplasticity in an Aluminum Alloy 6061/A12O3p Composite

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The superplasticity of an Al2O3p/6061Al composite, fabricated by powder metallurgy techniques,has been investigated. Instead of any special thermomechanical processing or hot rolling, simple hot extrusion has been employed to obtain a fine grained structure before superplastic testing.Superplastic tensile tests were performed at strain rates ranging from 10-2 to 10-4 s-1 and at temperatures from 833 to 893 K. A maximum elongation of 200% was achieved at a temperature of 853 K and an initial strain rate of 1.67×10-3 s-1. The highest value obtained for the strain rate sensitivity index (m) was 0.32. Differential scanning calorimeter was used to ascertain the possibility of any partial melting in the vicinity of optimum superplastic temperature. These results suggested that no liquid phase existed where maximum elongation was achieved and deformation took place entirely in the solid state.

  10. Precision Hyperfine Structure of 2;^3P State of ^3He with External Magnetic

    Science.gov (United States)

    Wu, Qixue; Drake, G. W. F.

    2007-06-01

    The theory of the Zeeman effect can be used to extrapolate precise measurements for the fine structure or the hyperfine structure to zero-field strength. In the present work, the hyperfine structure of 2;^3P state of ^3He with external magnetic fields is precisely calculated. The values of the fields for 32 crossings and five anticrossings of the magnetic sublevels are theoretically predicted for magnetic field strengths up to 1 Tesla. The results are compared with experimental work. We include the linear terms, diamagnetic terms, and the 2̂ relativistic correction terms in the Zeeman Hamiltonian. All related matrix elements are calculated with high accuracy by the use of double basis set Hylleraas type variational wave functions[1,2].[1] Z. -C. Yan and G.W.F. Drake, Phys. Rev. A 50, R1980 (1994).[2] Q. Wu and G.W.F. Drake, J. Phys. B 40, 393 (2007).

  11. Narrow-linewidth cooling of $^{6}$Li atoms using the 2S-3P transition

    CERN Document Server

    Chen, Hao-Ze; Wu, Yu-Ping; Liu, Xiang-Pei; Wang, Xiao-Qiong; Chen, Yu-Ao; Pan, Jian-Wei

    2016-01-01

    We report on a narrow-linewidth cooling of $^{6}$Li atoms using the $2S_{1/2}\\to 3P_{3/2}$ transition in the ultraviolet (UV) wavelength regime. By combining the traditional red magneto-optical trap (MOT) at 671 nm and the UV MOT at 323 nm, we obtain a cold sample of $1.3\\times10^9$ atoms with a temperature of 58 $\\mu$K. Furthermore, we demonstrate a high efficiency magnetic transport for $^{6}$Li atoms with the help of the UV MOT. Finally, we obtain $8.1\\times10^8$ atoms with a temperature of 296 $\\mu$K at a magnetic gradient of 198 G/cm in the science chamber with a good vacuum environment and large optical access.

  12. The Number of Solutions of the Diophantine Equation x2 + p2 =yn%Diophantine方程x2+p2=yn的解数

    Institute of Scientific and Technical Information of China (English)

    梁明

    2013-01-01

    Let p be a fixed odd prime,and let N(p) denote the number of positive integer solutions (x,y,n) of the equation x2 +p2 =yn satisfying gcd(x,y)=1 and n > 2.In this paper we prove that if p ≠ 7,then N(p) < log p.%对于给定的奇素数p,设N(p)为方程x2+ p2=yn满足gcd(x,y)=1和n>2的正整数解(x,y,n)的个数,本文证明了:当p≠7时,N(p) <log p.

  13. Functional Expression and Characterization of Schizosaccharomyces pombe Avt3p as a Vacuolar Amino Acid Exporter in Saccharomyces cerevisiae.

    Directory of Open Access Journals (Sweden)

    Soracom Chardwiriyapreecha

    Full Text Available In Saccharomyces cerevisiae, Avt3p and Avt4p mediate the extrusion of several amino acids from the vacuolar lumen into the cytosol. SpAvt3p of Schizosaccharomyces pombe, a homologue of these vacuolar amino acid transporters, has been indicated to be involved in spore formation. In this study, we confirmed that GFP-SpAvt3p localized to the vacuolar membrane in S. pombe. The amounts of various amino acids increased significantly in the vacuolar pool of avt3Δ cells, but decreased in that of avt3+-overexpressing avt3Δ cells. These results suggest that SpAvt3p participates in the vacuolar compartmentalization of amino acids in S. pombe. To examine the export activity of SpAvt3p, we expressed the avt3+ gene in S. cerevisiae cells. We found that the heterologously overproduced GFP-SpAvt3p localized to the vacuolar membrane in S. cerevisiae. Using the vacuolar membrane vesicles isolated from avt3+-overexpressing S. cerevisiae cells, we detected the export activities of alanine and tyrosine in an ATP-dependent manner. These activities were inhibited by the addition of a V-ATPase inhibitor, concanamycin A, thereby suggesting that the activity of SpAvt3p is dependent on a proton electrochemical gradient generated by the action of V-ATPase. In addition, the amounts of various amino acids in the vacuolar pools of S. cerevisiae cells were decreased by the overproduction of SpAvt3p, which indicated that SpAvt3p was functional in S. cerevisiae cells. Thus, SpAvt3p is a vacuolar transporter that is involved in the export of amino acids from S. pombe vacuoles.

  14. MicroRNA-490-3p inhibits proliferation of A549 lung cancer cells by targeting CCND1

    Energy Technology Data Exchange (ETDEWEB)

    Gu, Haihua; Yang, Tao; Fu, Shaozi; Chen, Xiaofan; Guo, Lei; Ni, Yiming, E-mail: ni_yiming@hotmail.com

    2014-01-31

    Highlights: • We examined the level of miR-490-3p in A549 lung cancer cells compared with normal bronchial epithelial cell line. • We are the first to show the function of miR-490-3p in A549 lung cancer cells. • We demonstrate CCND1 may be one of the targets of miR-490-3p. - Abstract: MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate the translation of messenger RNAs by binding their 3′-untranslated region (3′UTR). In this study, we found that miR-490-3p is significantly down-regulated in A549 lung cancer cells compared with the normal bronchial epithelial cell line. To better characterize the role of miR-490-3p in A549 cells, we performed a gain-of-function analysis by transfecting the A549 cells with chemically synthesized miR-490-3P mimics. Overexpression of miR-490-3P evidently inhibits cell proliferation via G1-phase arrest. We also found that forced expression of miR-490-3P decreased both mRNA and protein levels of CCND1, which plays a key role in G1/S phase transition. In addition, the dual-luciferase reporter assays indicated that miR-490-3P directly targets CCND1 through binding its 3′UTR. These findings indicated miR-490-3P could be a potential suppressor of cellular proliferation.

  15. Pre-Paid Charging System for Sip-P2P Commercial Applications

    Directory of Open Access Journals (Sweden)

    Damian Nowak

    2011-03-01

    Full Text Available The new SIP-P2P approach brings many advantages like the improved reliability and the ease of setup.However, Communications Service Providers (CSPs offering VoIP services seem to be afraid to losetheir profits due to the introduction of SIP-P2P. Claimed is the lack of session establishment controlleading to revenue leakages. In this work we introduce a charging system for SIP-P2P that assures CSPs’revenue from using SIP-based peer-to-peer communications commercially. The proposed solutionconsists of a new “carrier-grade P2P network” concept, software modification of existing equipment andgives some charging application design guidelines. An application prototype was implemented toexamine the concept. Additionally, experiments were done to provide the methodology for systemdimensioning.

  16. Implementing a Secure Key Issuing Scheme for Communication in P2P Networks

    Directory of Open Access Journals (Sweden)

    Mohammed Azharuddin

    2012-03-01

    Full Text Available Key issuing scheme focuses on the confidentiality maintained in using the secret key for communicationin p2p networks. Identity based cryptography (IBC was introduced into peer-to-peer (P2P networks recently for identity verification and authentication purposes. However, current IBC-based solutions were not addressing the problem of secure private key issuing. In this paper we propose a novel secure key issuing scheme for P2P networks using IBC. We present an IBC infrastructure setup phase, a peer registration solution using Shamir’s (k, n secret sharing scheme, and a secure key issuing scheme, which adopts key generate centre (KGC and key privacy authorities (KPAs to issue private keys to peers securely. This enables the IBC systems to be more acceptable and applicable in real-world P2P networks.

  17. A Local Scalable Distributed EM Algorithm for Large P2P Networks

    Data.gov (United States)

    National Aeronautics and Space Administration — his paper describes a local and distributed expectation maximization algorithm for learning parameters of Gaussian mixture models (GMM) in large peer-to-peer (P2P)...

  18. High-temperature behavior of vanadyl pyrophosphate (VO)2P2O7

    International Nuclear Information System (INIS)

    (VO)2P2O7 has been studied at high temperatures by in situ X-ray powder diffraction in an inert atmosphere. Lattice parameters indicate an anisotropic thermal expansion up to Tc=214-bar C, followed by an approximately isotropic expansion up to 490-bar C. It is proposed that Tc is the temperature of a second-order phase transition between the known room temperature form with space group Pca21 and a high-temperature form with space group Pcab. Above 490-bar C a minority phase develops in the sample that was identified as the V3+ containing compound V4(P2O7)3, while the anisotropic expansion along a suggests that stoichiometric (VO)2P2O7 transforms into (VO)2P2O7+x with interstitial oxygen located between the layers. With an onset at 706-bar C all of the (VO)2P2O7 transforms into VPO4

  19. Prognostic value of HMGA2, P16, and HPV in oral squamous cell carcinomas

    DEFF Research Database (Denmark)

    Loeschke, Siegfried; Ohlmann, Anne Katharina; Bräsen, Jan Hinrich;

    2016-01-01

    PURPOSE: Molecular markers are only occasionally used in diagnostics of oral squamous cell carcinoma (OSCC), even though they could influence decision making in individually designed cancer therapies. We analyzed the predictive value of the markers HPV, p16, and HMGA2 and the TNM classification...... effect on overall and progression-free survival. HMGA2 and N-status showed significant effects on overall (HMGA2: p = 0.049; N1: p = 0.019; N2: p = 0.02) and disease-free survival (HMGA2: p = 0.057; N1: p = 0.198; N2: p = 0.02). P16 appeared to be borderline significant but the χ(2) indicated that p16...

  20. Adaptive Routing Algorithms in Unstructured Peer-to-Peer (P2P Systems

    Directory of Open Access Journals (Sweden)

    Achmad Nizar Hidayanto,

    2011-02-01

    Full Text Available There are a variety of peer-to-peer (P2P systems for sharing documents currently available. According to their data organization, P2P systems are classified into two categories: structured andunstructured P2P systems. In structured P2P systems, peers are organized according to some mapping techniques, e.g. hashing function. Whereas in unstructured P2P system, peers are connected to each others randomly; resources are not moved to other peers but hosted on site. Unstructured P2P systems offer a more flexible and autonomous environment, as they require less control for the placement of resources and peers. This work focuses on experimenting on unstructured P2P systems. The challenge in unstructured P2P system is designing routing strategies that lead the user in finding the documents needed. Routing strategies in unstructured P2P system need to consider the dynamic aspects of P2P systems; peers are dynamic and constantly joining and leaving the system, network load changescontinuously and resources are added and removed over the time. Therefore, the routing strategy must adapt to such changes to maintain its performance. We propose routing strategies that adapt to these changes through learning mechanisms. The learning mechanisms are conducted by observing the internal and external behaviors of the system. Internal behaviors reflect the internal state of peers such as peers’ interest and collection. External behaviors reflect the external state of the system such as network load. In order to measure the performance of the proposed routing algorithms, some common performance measurements are used. These are “response time” and “number of messages generated” or what is commonly referred to as efficiency, “number of answered and satisfied queries” and the “similarity of documents” or what is commonly referred to as effectiveness of retrieval system. The experiment results show that the proposed algorithms are capable of adapting to

  1. Spectral Investigation of Crystalline (CuHPO4, Cu2P4O12, and Cu2P8O22 and Glassy Copper Phosphates

    Directory of Open Access Journals (Sweden)

    Christiane Günther

    2013-01-01

    Full Text Available Emerald green crystals of the new composition CuHPO4 were synthesized and compared to (copper metaphosphate Cu2P4O12 and (copper ultraphosphate Cu2P8O22. Various copper ultraphosphate and metaphosphate glasses of different compositions between pure P2O5 and Cu2P4O12 were melted in crucibles or in evacuated and sealed silica ampoules at 1473 K or 1373 K for 2 hrs. The UV-VIS-spectra and the IR-spectra of all crystals and glasses were measured and compared. The absorption band of Cu2+ was resolved into more component Gaussian bands and differentiated between square-pyramidal and octahedrally coordinated copper. These structural changes are responsible for colour changes from green to turquoise. The infrared spectroscopic properties of the copper phosphate glasses differ between metaphosphate and ultraphosphate structures but show similarities between the crystals and the glasses of the same structure type. EPR studies of some of the glasses show different kinds of spectra, with increasing copper content.

  2. An Efficient, Scalable and Robust P2P Overlay for Autonomic Communication

    Science.gov (United States)

    Li, Deng; Liu, Hui; Vasilakos, Athanasios

    The term Autonomic Communication (AC) refers to self-managing systems which are capable of supporting self-configuration, self-healing and self-optimization. However, information reflection and collection, lack of centralized control, non-cooperation and so on are just some of the challenges within AC systems. Since many self-* properties (e.g. selfconfiguration, self-optimization, self-healing, and self-protecting) are achieved by a group of autonomous entities that coordinate in a peer-to-peer (P2P) fashion, it has opened the door to migrating research techniques from P2P systems. P2P's meaning can be better understood with a set of key characteristics similar to AC: Decentralized organization, Self-organizing nature (i.e. adaptability), Resource sharing and aggregation, and Fault-tolerance. However, not all P2P systems are compatible with AC. Unstructured systems are designed more specifically than structured systems for the heterogeneous Internet environment, where the nodes' persistence and availability are not guaranteed. Motivated by the challenges in AC and based on comprehensive analysis of popular P2P applications, three correlative standards for evaluating the compatibility of a P2P system with AC are presented in this chapter. According to these standards, a novel Efficient, Scalable and Robust (ESR) P2P overlay is proposed. Differing from current structured and unstructured, or meshed and tree-like P2P overlay, the ESR is a whole new three dimensional structure to improve the efficiency of routing, while information exchanges take in immediate neighbors with local information to make the system scalable and fault-tolerant. Furthermore, rather than a complex game theory or incentive mechanism, asimple but effective punish mechanism has been presented based on a new ID structure which can guarantee the continuity of each node's record in order to discourage negative behavior on an autonomous environment as AC.

  3. Quantum Cohomology of Hilb^2(P^1xP^1) and Enumerative Applications

    OpenAIRE

    Pontoni, Dalide

    2004-01-01

    We compute the Small Quantum Cohomology of Hilb^2(P^1xP^1) and determine recursively most of the Big Quantum Cohomology. We prove a relationship between the invariants so obtained and the enumerative geometry of hyperelliptic curves in P^1xP^1. This extends the results obtained by Graber for Hilb^2(P^2) and hyperelliptic curves in P^2.

  4. A Group-oriented Access Control Scheme for P2P Networks

    OpenAIRE

    Wang Xiaoming; Cheng Fan

    2011-01-01

    A group-oriented access control scheme is proposed for P2P (peer to peer) networks. In the proposed scheme, authentication control, admission control and revocation control are used in order to provide security services for P2P networks. Moreover, the proposed scheme can simply and efficient establish share key between two members without interactions, therefore it can perform secure communications with them. The analysis of security and performance shows that the proposed scheme not only can...

  5. Quasi-elastic scattering, RPA, 2p2h and neutrino--energy reconstruction

    CERN Document Server

    Nieves, J; Sanchez, F; Vacas, M J Vicente

    2013-01-01

    We discuss some nuclear effects, RPA correlations and 2p2h (multinucleon) mechanisms, on charged-current neutrino-nucleus reactions that do not produce a pion in the final state. We study a wide range of neutrino energies, from few hundreds of MeV up to 10 GeV. We also examine the influence of 2p2h mechanisms on the neutrino energy reconstruction.

  6. Structure And Function of the Yeast U-Box-Containing Ubiquitin Ligase Ufd2p

    Energy Technology Data Exchange (ETDEWEB)

    Tu, D.; Li, W.; Ye, Y.; Brunger, A.T.

    2009-06-04

    Proteins conjugated by Lys-48-linked polyubiquitin chains are preferred substrates of the eukaryotic proteasome. Polyubiquitination requires an activating enzyme (E1), a conjugating enzyme (E2), and a ligase (E3). Occasionally, these enzymes only assemble short ubiquitin oligomers, and their extension to full length involves a ubiquitin elongating factor termed E4. Ufd2p, as the first E4 identified to date, is involved in the degradation of misfolded proteins of the endoplasmic reticulum and of a ubiquitin-{beta}-GAL fusion substrate in Saccharomyces cerevisiae. The mechanism of action of Ufd2p is unknown. Here we describe the crystal structure of the full-length yeast Ufd2p protein. Ufd2p has an elongated shape consisting of several irregular Armadillo-like repeats with two helical hairpins protruding from it and a U-box domain flexibly attached to its C terminus. The U-box of Ufd2p has a fold similar to that of the RING (Really Interesting New Gene) domain that is present in certain ubiquitin ligases. Accordingly, Ufd2p has all of the hallmarks of a RING finger-containing ubiquitin ligase: it associates with its cognate E2 Ubc4p via its U-box domain and catalyzes the transfer of ubiquitin from the E2 active site to Ufd2p itself or to an acceptor ubiquitin molecule to form unanchored diubiquitin oligomers. Thus, Ufd2p can function as a bona fide E3 ubiquitin ligase to promote ubiquitin chain elongation on a substrate.

  7. Enabling Co-located Learning over Mobile Ad Hoc P2P with LightPeers

    OpenAIRE

    Bent Guldbjerg Christensen; Mads Darø Kristensen; Frank Allan Hansen; Niels Olof Bouvin

    2008-01-01

    This paper presents LightPeers – a new mobile P2P framework specifically tailored for use in a nomadic learning environment. A set of key requirements for the framework is identified based on nomadic learning, and these requirements are used as outset for designing and implementing the architecture and protocols. The main contributions of the LightPeers framework are: a mobile P2P framework including a specialized robust messaging protocol resilient to changes in the network topology, an deve...

  8. Data transport and management in P2P Data Management in Mobile Wireless Sensor Network

    International Nuclear Information System (INIS)

    The rapid growth in wireless technologies has made wireless communication an important source for transporting data across different domains. In the same way, there are possibilities of many potential applications that can be deployed using WSNs (Wireless Sensor Networks). However, very limited applications are deployed in real life due to the uncertainty and dynamics of the environment and scare resources. This makes data management in WSN a challenging area to find an approach that suits its characteristics. Currently, the trend is to find efficient data management schemes using evolving technologies, i.e. P2P (Peer-to-Peer) systems. Many P2P approaches have been applied in WSNs to carry out the data management due to similarities between WSN and P2P. With the similarities, there are differences too that makes P2P protocols inefficient in WSNs. Furthermore, to increase the efficiency and to exploit the delay tolerant nature of WSNs, where ever possible, the mobile WSNs are gaining importance. Thus, creating a three dimensional problem space to consider, i.e. mobility, WSNs and P2P. In this paper, an efficient algorithm is proposed for data management using P2P techniques for mobile WSNs. The real world implementation and deployment of proposed algorithm is also presented. (author)

  9. P2P network traffic control mechanism based on global evaluation values

    Institute of Scientific and Technical Information of China (English)

    XU Xiao-long; WANG Ru-chuan

    2009-01-01

    Peer-to-peer (P2P) computing technology has been widely used on the Internet to exchange data. However, it occupies much network bandwidth, and thus greatly influences traditional business on the Interact. Besides, problems about free-riders and 'tragedy of the commons' in the P2P environment estrange from it P2P users who constantly contribute to the network with quality resources. This article proposes a new P2P network traffic control mechanism based on global evaluation values. It aims to help individual users to avoid peak traffic time as much as possible, ease network congestion and protect traditional business on the Interact, as well as differentiating priority grades of peers according to their contributions and stimulating them to share their valuable resources actively. This article first analyzes the current state of network traffic, and then elaborates on P2P network traffic control policies and proposes the peer's priority level differentiation mechanism based on global evaluation values. Finally,after the testing results and analysis of the proposed P2P network traffic control mechanism are discussed, conclusions are drawn.

  10. miR-224-3p inhibits autophagy in cervical cancer cells by targeting FIP200

    Science.gov (United States)

    Fang, Wang; Shu, Shan; Yongmei, Li; Endong, Zhu; Lirong, Yin; Bei, Sun

    2016-01-01

    Cervical cancer (CC) is a malignant solid tumor, which is one of the main causes of morbidity and mortality in women. Persistent High-risk human papillomavirus (hrHPV) infection is closely related to cervical cancer and autophagy has been suggested to inhibit viral infections. miRNAs have been reported to regulate autophagy in many solid tumors with many studies implicating miR-224-3p in the regulation of autophagy. In this study, we performed a miRNA microarray analysis on CC tissues and found that a large number of miRNAs with differential expressions in hrHPV-infected tissues. We identified miR-224-3p as a candidate miRNA selectively up regulated in HPV-infected tissues and cell lines. Further analysis revealed that miR-224-3p regulates autophagy in cervical cancer tissues and cell lines. While the overexpression of miR-224-3p inhibits autophagy in HPV-infected cells, knocking down endogenous miR-224-3p increases autophagy activity in the same cells. In addition, we found that miR-224-3p directly inhibits the expression of autophagy related gene, FAK family-interacting protein of 200 kDa (FIP200). In summary, we found that miR-224-3p regulates autophagy in hrHPV-induced cervical cancer cells through targeting FIP200 expression. PMID:27615604

  11. Expression of miR-199a-3p in human adipocytes is regulated by free fatty acids and adipokines.

    Science.gov (United States)

    Gu, Nan; You, Lianghui; Shi, Chunmei; Yang, Lei; Pang, Lingxia; Cui, Xianwei; Ji, Chenbo; Zheng, Wen; Guo, Xirong

    2016-08-01

    Obesity is associated with a notable risk for disease, including risk of cardiovascular disorders, type 2 diabetes mellitus (T2DM) and hypertension. Adipose tissue modulates the metabolism by releasing free fatty acids (FFAs) and adipokines, including leptin, resistin, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL‑6). Altered secretion patterns of FFAs and adipokines have been demonstrated to result in obesity‑associated insulin resistance (IR) and inflammatory responses. MicroRNA-199a-3p (miR)-199a-3p expression is significantly induced in differentiated human adipose-derived mesenchymal stem cells and indicates the association with T2DM. However, the association between miR-199a-3p levels in adipocytes and obesity‑associated IR, as well as inflammatory responses remains to be elucidated. The present study observed an elevation of miR‑199a‑3p expression level in mature human adipocytes (visceral) compared with pre-adipocytes. In addition, miR‑199a‑3p expression was higher in visceral adipose deposits from obese subjects. FFA, TNF-α, IL‑6 and leptin significantly induced miR‑199a‑3p expression in mature human adipocytes, while resistin had the opposite effect. miR‑199a‑3p may represent a factor in the modulation of obesity‑associated IR and inflammatory responses. PMID:27279151

  12. miR-224-3p inhibits autophagy in cervical cancer cells by targeting FIP200.

    Science.gov (United States)

    Fang, Wang; Shu, Shan; Yongmei, Li; Endong, Zhu; Lirong, Yin; Bei, Sun

    2016-01-01

    Cervical cancer (CC) is a malignant solid tumor, which is one of the main causes of morbidity and mortality in women. Persistent High-risk human papillomavirus (hrHPV) infection is closely related to cervical cancer and autophagy has been suggested to inhibit viral infections. miRNAs have been reported to regulate autophagy in many solid tumors with many studies implicating miR-224-3p in the regulation of autophagy. In this study, we performed a miRNA microarray analysis on CC tissues and found that a large number of miRNAs with differential expressions in hrHPV-infected tissues. We identified miR-224-3p as a candidate miRNA selectively up regulated in HPV-infected tissues and cell lines. Further analysis revealed that miR-224-3p regulates autophagy in cervical cancer tissues and cell lines. While the overexpression of miR-224-3p inhibits autophagy in HPV-infected cells, knocking down endogenous miR-224-3p increases autophagy activity in the same cells. In addition, we found that miR-224-3p directly inhibits the expression of autophagy related gene, FAK family-interacting protein of 200 kDa (FIP200). In summary, we found that miR-224-3p regulates autophagy in hrHPV-induced cervical cancer cells through targeting FIP200 expression. PMID:27615604

  13. MicroRNA-338-3p suppresses tumor growth of esophageal squamous cell carcinoma in vitro and in vivo.

    Science.gov (United States)

    Li, Xinyu; Li, Zhihong; Yang, Guiyun; Pan, Zhenxiang

    2015-09-01

    Accumulating evidence has shown that microRNAs (miRNAs) are aberrantly expressed in human esophageal squamous cell carcinoma (ESCC) and are crucial in tumorigenesis, among which miR‑338‑3p has been examined to be downregulated in patients with ESCC. However, the role of miR‑338‑3p in ESCC remains to be elucidated. In the present study, the role of miR‑338‑3p on the growth and survival of an ESCC cell line was determined with several in vitro approaches and in nude mouse models. It was determined that miR‑338‑3p expression was frequently downregulated in ESCC tissue compared with corresponding adjacent non‑tumor tissue, and that its expression was significantly correlated with tumor stage and metastasis. Overexpression of miR‑338‑3p in ESCC cells suppressed cell proliferation, colony formation, migration and invasion, and induced cell arrest at the G0/G1 stage and cell apoptosis in vitro. In addition, it was demonstrated that overexpression of miR‑338‑3p significantly suppresses tumor growth of xenograft tumors in mice (PESCC, and its dysregulation may be involved in the initiation and development of human ESCC. In addition, it was suggested that miR‑338‑3p may be a potential therapeutic agent for treatment of ESCC.

  14. P2P-based botnets: structural analysis, monitoring, and mitigation

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Guanhua [Los Alamos National Laboratory; Eidenbenz, Stephan [Los Alamos National Laboratory; Ha, Duc T [UNIV AT BUFFALO; Ngo, Hung Q [UNIV AT BUFFALO

    2008-01-01

    Botnets, which are networks of compromised machines that are controlled by one or a group of attackers, have emerged as one of the most serious security threats on the Internet. With an army of bots at the scale of tens of thousands of hosts or even as large as 1.5 million PCs, the computational power of botnets can be leveraged to launch large-scale DDoS (Distributed Denial of Service) attacks, sending spamming emails, stealing identities and financial information, etc. As detection and mitigation techniques against botnets have been stepped up in recent years, attackers are also constantly improving their strategies to operate these botnets. The first generation of botnets typically employ IRC (Internet Relay Chat) channels as their command and control (C&C) centers. Though simple and easy to deploy, the centralized C&C mechanism of such botnets has made them prone to being detected and disabled. Against this backdrop, peer-to-peer (P2P) based botnets have emerged as a new generation of botnets which can conceal their C&C communication. Recently, P2P networks have emerged as a covert communication platform for malicious programs known as bots. As popular distributed systems, they allow bots to communicate easily while protecting the botmaster from being discovered. Existing work on P2P-based hotnets mainly focuses on measurement of botnet sizes. In this work, through simulation, we study extensively the structure of P2P networks running Kademlia, one of a few widely used P2P protocols in practice. Our simulation testbed incorporates the actual code of a real Kademlia client software to achieve great realism, and distributed event-driven simulation techniques to achieve high scalability. Using this testbed, we analyze the scaling, reachability, clustering, and centrality properties of P2P-based botnets from a graph-theoretical perspective. We further demonstrate experimentally and theoretically that monitoring bot activities in a P2P network is difficult

  15. MicroRNA-23a-3p promotes the development of osteoarthritis by directly targeting SMAD3 in chondrocytes.

    Science.gov (United States)

    Kang, Liang; Yang, Cao; Song, Yu; Liu, Wei; Wang, Kun; Li, Shuai; Zhang, Yukun

    2016-09-01

    Osteoarthritis (OA) is a common chronic degenerative joint disease. Progressive destruction of the integrity of articular cartilage is an important pathological feature, but treatment options that reverse this damage have not been developed. According to recent studies, microRNAs have important regulatory roles in the initiation and progression of OA. In the current study, the biological effects of miR-23a-3p and its expression in OA tissues were examined. We found that miR-23a-3p expression was obviously higher and SMAD3 expression was significantly lower in OA cartilage than in normal tissues. The hypomethylation status of CpG islands in the promoter region of miR-23a-3p was confirmed by methylation-specific polymerase chain reaction in OA cartilage tissues. Furthermore, a bioinformatics analysis and luciferase reporter assay identified SMAD3 as a target gene of miR-23a-3p and SMAD3 expression at both the protein and mRNA levels was inhibited by miR-23a-3p. A functional analysis demonstrated that miR-23a-3p overexpression suppresses type II collagen and aggrecan expression, while miR-23a-3p inhibition had the opposite effects. Small interfering RNA-mediated knockdown of SMAD3 reversed the effects of the miR-23a-3p inhibitor on the expression of type II collagen and aggrecan. Our results suggested that miR-23a-3p contributes to OA progression by directly targeting SMAD3, providing a potential therapeutic target for OA treatment. PMID:27318087

  16. miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Peng; Wu, Dingguo; You, Yu; Sun, Jing; Lu, Lele; Tan, Jiaxing; Bie, Ping, E-mail: bieping2010@163.com

    2015-08-15

    MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment. - Highlights: • miR-208-3p was highly expressed and directly repressed the expression of ARID2 in HCC. • miR-208-3p contributed to HCC cell progression both in vitro and in vivo. • Over-expression of ARID2 inhibited the HCC cell proliferation and invasion. • Restoration of ARID2 partly reversed the the effect of miR-208-3p down-regulation on HCC cells. • Newly regulatory pathway: miR-208-3p mediated the repression of ARID2 by TGFβ1 in HCC cells.

  17. Multifunctional g3p-peptide tag for current phage display systems.

    Science.gov (United States)

    Beckmann, C; Haase, B; Timmis, K N; Tesar, M

    1998-03-15

    We have previously described a monoclonal antibody (mAb), 10C3, directed against the gene-3 protein (g3p) of filamentous phage M13, which was produced to study g3p fusion protein expression in Escherichia coli and its incorporation in the phage capsid [Tesar, M., Beckmann, C., Röttgen, P., Haase, B., Faude, U., Timmis, K., 1995. Monoclonal antibody against pIII of filamentous phage: an immunological tool to study pIII fusion protein expression in phage display systems. Immunology 1, 53-54]. In this study we report mapping of the antigenic epitope of the mAb 10C3, by means of short overlapping peptide-sequences [Frank, R., Overwin, H., 1996. Spot synthesis. In: Morris, G.E. (Ed.), Methods in Molecular Biology, Vol. 66: Epitope Mapping Protocols. Humana Press, Totowa, NJ, pp. 149-169.] comprising the C-terminal half of the g3-protein. A minimal recognizable peptide was found which is represented in the 11 amino acid sequence from positions 292 to 302 of g3p [Wezenbeek van, P.M.G.P., Hulsebos, T.J.M., Schoenmakers, J.G.G., 1980. Nucleotide sequence of the filamentous bacteriophage M13 DNA genome: comparison with phage fd. Gene 11, 129-148]. In order to use the antibody also for detection and purification of recombinant proteins, such as single chain antibodies, the epitope was introduced as a tag sequence into the phagemid pHEN1 [Hoogenboom, H.R., Griffith, A.D., Johnson, K., Chiswell, D.J., Hudson, P., Winter, G., 1991. Multi-subunit proteins on the surface of the filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains. Nucleic Acid Res. 19, 4133-4137; Nissim, A., Hoogenboom, H.R., Tomlinson, I.M., Flynn, G., Midgley, C., Lane, D., Winter, G., 1994. Antibody fragments from a single pot phage display library as immunochemical reagents. EMBO J. 13 (3) 692-698]. Purified single chain antibodies containing this tag were detectable down to a concentration of 2 ng ml(-1) under non-denaturing conditions (ELISA) or 4 ng per lane on immunoblots

  18. Measurement of Integrated Stokes Parameters for He 3 3p State Excited by Spin-Polarized Electrons

    Institute of Scientific and Technical Information of China (English)

    DING Hai-Bing; PANG Wen-Ning; LIU Yi-Bao; SHANG Ren-Cheng

    2005-01-01

    @@ Integrated Stokes parameters Pi (i = 1, 2, 3) for the He 3 3p → 2 3S1 (388.9nm) transition after excitation from the ground state to the 3 3 P state by a transversely spin-polarized electron beam are measured in near threshold energy region. The experimental results are presented. The linear-polarization P2 are consistent with zero over the incident energy range, providing evidence for the LS coupling mechanism of the 3 3P state. The measured circular polarization P3 are non-zero, indicating strong electron-electron exchange effects in the spin-polarized electron-atom collision process.

  19. Hyperfine Quenching of the $4s4p ^{3}P_{0}$ Level in Zn-like Ions

    CERN Document Server

    Marques, J P; Indelicato, Paul

    2007-01-01

    In this paper, we used the multiconfiguration Dirac-Fock method to compute with high precision the influence of the hyperfine interaction on the $[Ar]3d^{10} 4s4p ^3P_0$ level lifetime in Zn-like ions for stable and some quasi-stable isotopes of nonzero nuclear spin between Z=30 and Z=92. The influence of this interaction on the $[Ar]3d^{10} 4s4p ^3P_1 - [Ar]3d^{10} 4s4p ^3P_0$ separation energy is also calculated for the same ions.

  20. Energy-band alignment of II-VI/Zn3P2 heterojunctions from x-ray photoemission spectroscopy

    OpenAIRE

    Watson, Graeme

    2013-01-01

    PUBLISHED The energy-band alignments for zb-ZnSe(001)/ a -Zn 3 P 2 (001), w-CdS(0001)/ a -Zn 3 P 2 (001), and w-ZnO(0001)/ a -Zn 3 P 2 (001) heterojunctions have been determined using high-resolution x-ray photoelectron spectroscopy via the Kraut method. Ab initio hybrid density functional theory calculations of the valence-band density of states were used to determine the energy differences between the core level and ...

  1. EuCo2P2 : A model molecular-field helical Heisenberg antiferromagnet

    Science.gov (United States)

    Sangeetha, N. S.; Cuervo-Reyes, Eduardo; Pandey, Abhishek; Johnston, D. C.

    2016-07-01

    The metallic compound EuCo2P2 with the body-centered tetragonal ThCr2Si2 structure containing Eu spins-7/2 was previously shown from single-crystal neutron diffraction measurements to exhibit a helical antiferromagnetic (AFM) structure below TN=66.5 K with the helix axis along the c axis and with the ordered moments aligned within the a b plane. Here we report crystallography, electrical resistivity, heat capacity, magnetization, and magnetic susceptibility measurements on single crystals of this compound. We demonstrate that EuCo2P2 is a model molecular-field helical Heisenberg antiferromagnet from comparisons of the anisotropic magnetic susceptibility χ , high-field magnetization, and magnetic heat capacity of EuCo2P2 single crystals at temperature T ≤TN with the predictions of our recent formulation of molecular-field theory. Values of the Heisenberg exchange interactions between the Eu spins are derived from the data. The low-T magnetic heat capacity ˜T3 arising from spin-wave excitations with no anisotropy gap is calculated and found to be comparable to the lattice heat capacity. The density of states at the Fermi energy of EuCo2P2 and the related compound BaCo2P2 are found from the heat capacity data to be large, 10 and 16 states/eV per formula unit for EuCo2P2 and BaCo2P2 , respectively. These values are enhanced by a factor of ˜2.5 above those found from DFT electronic structure calculations for the two compounds. The calculations also find ferromagnetic Eu-Eu exchange interactions within the a b plane and AFM interactions between Eu spins in nearest- and next-nearest planes, in agreement with the MFT analysis of χa b(T ≤TN) .

  2. Theoretical Stark widths and shifts of spectral lines of 2p5nf and 2p55g configurations of Mg III

    Science.gov (United States)

    Moreno-Díaz, Cristina; Alonso-Medina, Aurelia; Colón, Cristóbal

    2014-11-01

    In this paper, we report theoretical Stark widths and shifts calculated using the Griem semi-empirical approach, which corresponds to 111 spectral lines of Mg III. The values of these Stark broadening parameters of spectral lines that arise from levels of 2p5nf and 2p55g configurations of Mg III are presented in the literature for the first time. The aim of this work is to provide values to estimate the electron density of plasma Mg III in astrophysics and industrial applications. The data are presented for the temperatures T = 0.5-10.0 (104 K) and for an electron density of 1017 cm-3. The matrix of elements used in these calculations has been determined from 23 configurations of Mg III: 2s22p6, 2s22p53p, 2s22p54p, 2s22p54f and 2s22p55f for the even parity and 2s22p5ns (n = 3-6), 2s22p5nd (n = 3-9), 2s22p55g and 2s2p6np (n = 3-8) for the odd parity. For the intermediate coupling calculations, we use the standard method of least square fitting from experimental energy levels by means of Cowan’s computer code. Lines with wavelengths of 134.6460, 135.2800, 189.0380, 190.0043, 192.8424, 408.2939 and 409.4375 nm have high probabilities and also have high values of broadening. Therefore, these lines can be used in some applications. A common regularity for the Stark width of the 189.038 nm spectral line of Mg III is discussed.

  3. Join the CERN ISEF special award winners | 16 June - 3 p.m.

    CERN Multimedia

    2016-01-01

    Come and join the CERN ISEF special award winners at their lightning talks session on 16 June at 3.00 p.m. in the main auditorium.   The 2016 Intel ISEF CERN special award winners on stage with the selection committee on 17 May 2016 in Phoenix, Arizona, USA. (Picture: Society for Science and the Public) Between 11 and 17 June 2016, the ten finalists of the Intel International Science and Engineering Fair (ISEF) who won the CERN Special Award, will visit CERN to partake in various educational lectures. ISEF is the world's largest international pre-college science competition, with approximately 1,700 high school students from more than 75 countries taking part. They will present their projects in short 5 minutes lightning talks' sessions at the main auditorium on Thursday 16 June at 3 p.m. The award winners would be also very happy to have a chance to interact and discuss with you af...

  4. Dynamics of the gas-liquid interfacial reaction of O(3P) atoms with hydrocarbons

    Science.gov (United States)

    Kelso, Hailey; Köhler, Sven P. K.; Henderson, David A.; McKendrick, Kenneth G.

    2003-11-01

    We describe an experimental approach to the determination of the nascent internal state distribution of gas-phase products of a gas-liquid interfacial reaction. The system chosen for study is O(3P) atoms with the surface of liquid deuterated squalane, a partially branched long-chain saturated hydrocarbon, C30D62. The nascent OD products are detected by laser-induced fluorescence. Both OD (v'=0) and (v'=1) were observed in significant yield. The rotational distributions in both vibrational levels are essentially the same, and are characteristic of a Boltzmann distribution at a temperature close to that of the liquid surface. This contrasts with the distributions in the corresponding homogeneous gas-phase reactions. We propose a preliminary interpretation in terms of a dominant trapping-desorption mechanism, in which the OD molecules are retained at the surface sufficiently long to cause rotational equilibration but not complete vibrational relaxation. The significant yield of vibrationally excited OD also suggests that the surface is not composed entirely of -CD3 endgroups, but that secondary and/or tertiary units along the backbone are exposed.

  5. Theoretical investigation of hyperthermal reactions at the gas-liquid interface: O (3P) and squalane.

    Science.gov (United States)

    Kim, Dongwook; Schatz, George C

    2007-06-14

    Hyperthermal collisions (5 eV) of ground-state atomic oxygen [O ((3)P)] with a liquid-saturated hydrocarbon, squalane (C(30)H(62)), have been studied using QM/MM hybrid "on-the-fly" direct dynamics. The surface structure of the liquid squalane is obtained from a classical molecular dynamics simulation using the OPLS-AA force field. The MSINDO semiempirical Hamiltonian is combined with OPLS-AA for the QM/MM calculations. In order to achieve a more consistent and efficient simulation of the collisions, we implemented a dynamic partitioning of the QM and MM atoms in which atoms are assigned to QM or MM regions based on their proximity to "seed" (open-shell) atoms that determine where bond making/breaking can occur. In addition, the number of seed atoms is allowed to increase or decrease as time evolves so that multiple reactive events can be described. The results show that H abstraction is the most important process for all incident angles, with H elimination, double H abstraction, and C-C bond cleavage also being important. A number of properties of these reactive channels, as well as inelastic nonreactive scattering, are investigated, including angular and translational energy distributions, the effect of incident collision angle, variation with depth of the reactive event within the liquid, with the reaction site on the hydrocarbon, and the effect of dynamics before and after reaction (direct reaction versus trapping reaction-desorption).

  6. Dynamics of interfacial reactions between O(3 P) atoms and long-chain liquid hydrocarbons

    Science.gov (United States)

    Allan, Mhairi; Bagot, Paul A. J.; Köhler, Sven P. K.; Reed, Stewart K.; Westacott, Robin E.; Costen, Matthew L.; McKendrick, Kenneth G.

    2007-09-01

    Recent progress that has been made towards understanding the dynamics of collisions at the gas-liquid interface is summarized briefly. We describe in this context a promising new approach to the experimental study of gas-liquid interfacial reactions that we have introduced. This is based on laser-photolytic production of reactive gas-phase atoms above the liquid surface and laser-spectroscopic probing of the resulting nascent products. This technique is illustrated for reaction of O(3P) atoms at the surface of the long-chain liquid hydrocarbon squalane (2,6,10,15,19,23-hexamethyltetracosane). Laser-induced fluorescence detection of the nascent OH has revealed mechanistically diagnostic correlations between its internal and translational energy distributions. Vibrationally excited OH molecules are able to escape the surface. At least two contributions to the product rotational distributions are identified, confirming and extending previous hypotheses of the participation of both direct and trapping-desorption mechanisms. We speculate briefly on future experimental and theoretical developments that might be necessary to address the many currently unanswered mechanistic questions for this, and other, classes of gas-liquid interfacial reaction.

  7. The SET domain protein, Set3p, promotes the reliable execution of cytokinesis in Schizosaccharomyces pombe.

    Directory of Open Access Journals (Sweden)

    Stefan Rentas

    Full Text Available In response to perturbation of the cell division machinery fission yeast cells activate regulatory networks that ensure the faithful completion of cytokinesis. For instance, when cells are treated with drugs that impede constriction of the actomyosin ring (low doses of Latrunculin A, for example these networks ensure that cytokinesis is complete before progression into the subsequent mitosis. Here, we identify three previously uncharacterized genes, hif2, set3, and snt1, whose deletion results in hyper-sensitivity to LatA treatment and in increased rates of cytokinesis failure. Interestingly, these genes are orthologous to TBL1X, MLL5, and NCOR2, human genes that encode components of a histone deacetylase complex with a known role in cytokinesis. Through co-immunoprecipitation experiments, localization studies, and phenotypic analysis of gene deletion mutants, we provide evidence for an orthologous complex in fission yeast. Furthermore, in light of the putative role of the complex in chromatin modification, together with our results demonstrating an increase in Set3p levels upon Latrunculin A treatment, global gene expression profiles were generated. While this analysis demonstrated that the expression of cytokinesis genes was not significantly affected in set3Δ backgrounds, it did reveal defects in the ability of the mutant to regulate genes with roles in the cellular response to stress. Taken together, these findings support the existence of a conserved, multi-protein complex with a role in promoting the successful completion of cytokinesis.

  8. Half-quantized Non-Abelian Vortices in Neutron $^3P_2$ Superfluids inside Magnetars

    CERN Document Server

    Masuda, Kota

    2016-01-01

    We point out that half-quantized non-Abelian vortices exist as the minimum energy states in rotating neutron $^3P_2$ superfluids in the inner cores of magnetars with magnetic field greater than $3 \\times 10^{15}$ Gauss, while they do not in ordinary neutron stars with smaller magnetic fields. One integer vortex is split into two half-quantized vortices. The number of vortices is about $10^{19}$ and they are separated at about $\\mu$m in a vortex lattice for typical parameters, while the vortex core size is about 10-100 fm. They are non-Abelian vortices characterized by non-Abelian first homotopy group, and consequently when two vortices corresponding to non-commutative elements collide, a rung vortex must be created between them, implying the formation of an entangled vortex network inside the cores of magnetars. We find the spontaneous magnetization in the vortex core showing anti-ferromagnetism whose typical magnitude is about $10^{8-9}$ Gauss that is ten times larger than that of integer vortices, when exte...

  9. Functional expression of pig renal organic anion transporter 3 (pOAT3).

    Science.gov (United States)

    Hagos, Yohannes; Braun, Isabella M; Krick, Wolfgang; Burckhardt, Gerhard; Bahn, Andrew

    2005-05-01

    With the cloning of pig renal organic anion transporter 1 (pOAT1) (Biochimie 84 (2002) 1219) we set up a model system for comparative studies of cloned and natively isolated membrane located transport proteins. Meanwhile, another transport protein involved in p-aminohippurate (PAH) uptake on the basolateral side of the proximal tubule cells was identified, designated organic anion transporter 3 (OAT3). To explore the contribution of pOAT1 to the PAH clearance in comparison to OAT3, it was the aim of this study to extend our model by cloning of the pig ortholog of OAT3. Sequence comparisons of human organic anion transporter 3 (hOAT3) with the expressed sequence tag (EST) database revealed a clone and partial sequence of the pig renal organic anion transporter 3 (pOAT3) ortholog. Sequencing of the entire open reading frame resulted in a protein of 543 amino acid residues encoded by 1632 base pairs (EMBL Acc. No. AJ587003). It showed high homologies of 81%, 80%, 76%, and 77% to the human, rabbit, rat, and mouse OAT3, respectively. A functional characterization of pOAT3 in Xenopus laevis oocytes yielded an apparent Km (Kt) for [3H]estrone sulfate of 7.8 +/- 1.3 microM. Moreover, pOAT3 mediated [3H]estrone sulfate uptake was almost abolished by 0.5 mM of glutarate, dehydroepiandosterone sulfate, or probenecid consistent with the hallmarks of OAT3 function.

  10. Precision frequency measurement of 1S0–3P1 intercombination lines of Sr isotopes

    International Nuclear Information System (INIS)

    We report on frequency measurement of the intercombination (5s2)1S0–(5s5p)3P1 transition of the four natural isotopes of strontium, including 88Sr (82.58%), 87Sr (7.0%), 86Sr (9.86%), and 84Sr (0.56%). A narrow-linewidth laser that is locked to an ultra-low expansion (ULE) optical cavity with a finesse of 12000 is evaluated at a linewidth of 200 Hz with a fractional frequency drift of 2.8×10−13 at an integration time of 1 s. The fluorescence collector and detector are specially designed, based on a thermal atomic beam. Using a double-pass acousto-optic modulator (AOM) combined with a fiber and laser power stabilization configuration to detune the laser frequency enables high signal-to-noise ratios and precision saturated spectra to be obtained for the six transition lines, which allows us to determine the transition frequency precisely. The optical frequency is measured using an optical frequency synthesizer referenced to an H maser. Both the statistical values and the final values, including the corrections and uncertainties, are derived for a comparison with the values given in other works. (paper)

  11. ACE3P Computations of Wakefield Coupling in the CLIC Two-Beam Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Candel, Arno; Li, Z.; Ng, C.; Rawat, V.; Schussman, G.; Ko, K.; /SLAC; Syratchev, I.; Grudiev, A.; Wuensch, W.; /CERN

    2010-10-27

    The Compact Linear Collider (CLIC) provides a path to a multi-TeV accelerator to explore the energy frontier of High Energy Physics. Its novel two-beam accelerator concept envisions rf power transfer to the accelerating structures from a separate high-current decelerator beam line consisting of power extraction and transfer structures (PETS). It is critical to numerically verify the fundamental and higher-order mode properties in and between the two beam lines with high accuracy and confidence. To solve these large-scale problems, SLAC's parallel finite element electromagnetic code suite ACE3P is employed. Using curvilinear conformal meshes and higher-order finite element vector basis functions, unprecedented accuracy and computational efficiency are achieved, enabling high-fidelity modeling of complex detuned structures such as the CLIC TD24 accelerating structure. In this paper, time-domain simulations of wakefield coupling effects in the combined system of PETS and the TD24 structures are presented. The results will help to identify potential issues and provide new insights on the design, leading to further improvements on the novel CLIC two-beam accelerator scheme.

  12. Utilising the `3P-model' to Characterise the Discipline of Didactics of Science

    Science.gov (United States)

    Adúriz-Bravo, Agustín; Izquierdo-Aymerich, Mercè

    In our research within didactics of science, we have been exploring contributions of the so called cognitive models from contemporary philosophy of science. We have used these philosophical frameworks on different levels. As an outcome, we have formulated a model of didactics of science according to which this discipline adapts and transforms theoretical contributions from different scholarly fields. In this paper, we concentrate on this description of didactics of science, which we have called the 3P-model (i.e., philosophy + psychology + pedagogy). This model of the internal functioning of the discipline may be useful to make innovations in science curriculum design and re-conceptualise the role of science teachers as professionals. We see didactics of science as a set of interrelated activities, performed by different individuals, and ranging from theoretical production to practice of science education at school. We find the concept of technoscience suitable to account for this diversity of goals. According to this concept, scientific disciplines are identified both with generation of knowledge and with active intervention on the world. Within current didactics of science, we recognise several kinds of research, having goals more or less directed to practical intervention in science education.

  13. Distributed Peer Discovery in Large-Scale P2P Streaming Systems : Addressing Practical Problems of P2P Deployments on the Open Internet

    OpenAIRE

    Jimenez, Raul

    2013-01-01

    Peer-to-peer (P2P) techniques allow users with limited resources to distribute content to a potentially large audience by turning passive clients into peers. Peers can self-organize to distribute content to each other, increasing the scalability of the system and decreasing the publisher’s costs, compared to a publisher distributing the data himself using a content delivery network (CDN) or his own servers. Peer discovery is the mechanism that peers use to find each other. Peer discovery is a...

  14. 基于Super Peer的P2P e-Learning模型%New P2P e-Learning model based on Super Peer

    Institute of Scientific and Technical Information of China (English)

    陈金儿; 王让定

    2007-01-01

    在分析各种P2P网络特点的基础上,提出了分布式环境中基于超节点的P2P e-Learning模型.对特定peer组中超节点的加入和超节点的服务进行了具体描述.针对e-Learning的特性,给出了模型中的数据抽象和本体描述,并对该P2P网络模型在文件传输方面的性能做了分析.

  15. 2P/Encke, the Taurid complex NEOs and the Maribo and Sutter's Mill meteorites

    CERN Document Server

    Tubiana, C; Michelsen, R; Haack, H; Boehnhardt, H; Fitzsimmons, A; Williams, I P

    2015-01-01

    The Taurid meteoroid stream has long been linked with 2P/Encke owing to a good match of their orbital elements, even though the comet's activity is not strong enough to explain the number of observed meteors. Various small NEOs have been discovered with orbits that can be linked to 2P and the Taurid meteoroid stream. Maribo and Sutter's Mill are CM type carbonaceous chondrites that fell in Denmark on Jan 17, 2009 and Apr 22, 2012, respectively. Their pre-atmospheric orbits place them in the middle of the Taurid meteoroid stream, which raises the intriguing possibility that comet 2P could be the parent body of CM chondrites. To investigate whether a relationship between comet 2P, the Taurid complex associated NEOs, and CM chondrites exists, we performed photometric and spectroscopic studies of these objects in the visible wavelength range. We observed 2P and 10 NEOs on Aug 2, 2011 with FORS at the VLT. Images in the R filter, used to investigate the possible presence of cometary activity around the nucleus of ...

  16. RESEARCH ON GROUPING STRATEGY OF SIP-BASED STREAMING MEDIA P2P LIVE BROADCAST NETWORK

    Institute of Scientific and Technical Information of China (English)

    Liu Hui; Huang Yongfeng; Li Xing

    2008-01-01

    The rapid development of Internet has led to the explosion of information sharing, and how to supervise the sharing is a main research topic on current Internet. Aiming at the disadvantage that the current Peer-to-Peer (P2P) is hard to manage and control, this paper presents a Session Initial Protocol (SIP)-based P2P network of three-level architecture. SIP middleware is introduced to the middle level of the three-layer architecture. By the connection function of the SIP signaling, the P2P transmission on media-level can be controlled. Using SIP's register and authentication function, the manage layer can manage the whole P2P network. Based on the aforementioned architecture, this paper investigates the grouping strategy on a live broadcast application in P2P network. Combined with the function of SIP register, the paper works on several grouping strategies, sets up models to manage users by grouping them, presents a weight-based K-means IP address grouping algorithm, and realizes it. The experiment shows that the grouping strategy presented in this paper can solve the problem of group sharing of network resource, and can realize the efficient-sharing, reasonable-distributing of network resource.

  17. Large-Scale Mini-Magnetosphere Plasma Propulsion (M2P2) Experiments

    Science.gov (United States)

    Winglee, R. M.; Slough, J.; Ziemba, T.; Euripides, P.; Adrian, M. L.; Gallagher, D.; Craven, P.; Tomlinson, W.; Cravens, J.; Burch, J.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    Mini-Magnetosphere Plasma Propulsion (M2P2) is an innovative plasma propulsion system that has the potential to propel spacecraft at unprecedented speeds of 50 to 80 km per second with a low-power requirement of approx. 1 kW per 100 kg of payload and approx. 1 kg of neutral gas [fuel] consumption per day of acceleration. Acceleration periods from several days to a few months are envisioned. High specific impulse and efficiency are achieved through coupling of the spacecraft to the 400 km per second solar wind through an artificial magnetosphere. The mini-magnetosphere or inflated magnetic bubble is produced by the injection of cold dense plasma into a spacecraft-generated magnetic field envelope. Magnetic bubble inflation is driven by electromagnetic processes thereby avoiding the material and deployment problems faced by mechanical solar sail designs, Here, we present the theoretical design of M2P2 as well as initial results from experimental testing of an M2P2 prototype demonstrating: 1) inflation of the dipole magnetic field geometry through the internal injection of cold plasma; and 2) deflection of and artificial solar wind by the prototype M2P2 system. In addition, we present plans for direct laboratory measurement of thrust imparted to a prototype M2P2 by an artificial solar wind during the summer of 2001.

  18. Secure mobile agent for telemedicine based on P2P networks.

    Science.gov (United States)

    Hsu, Wen-Shin; Pan, Jiann-I

    2013-06-01

    Exploring intelligent mobile agent (MA) technology for assisting medical services or transmitting personal patient-health information in telemedicine applications has been widely investigated. Conversely, peer-to-peer (P2P) networking has become one of the most popular applications used in the Internet because of its benefits for easy-to-manage resources and because it balances workloads. Therefore, constructing an agent-based telemedicine platform based on P2P networking architecture is necessary. The main purpose of this paper is to construct a safe agent-based telemedicine that based on P2P networking architecture. Two themes are addressed in this paper: (a) the P2P network architecture for an agent-based telemedicine service, and (b) the security mechanisms for the proposed telemedicine networking architecture. When an MA contains patient information and migrates from one host to another through the Internet, it can be attacked by other software agents or agent platforms that can illegally access patient information. The proposed P2P network architecture is based on the JXTA protocol and provides two types of telemedicine service models: the predictable service model and unpredictable service model. This architecture employs a two-layer safety mechanism for MAs (i.e., time-limited black boxes and RSA undetachable signature technologies), to provide a secure solution for agent-based telemedicine services. PMID:23605144

  19. P2P Streaming Traffic Classification in High-Speed Networks

    Institute of Scientific and Technical Information of China (English)

    Chen Luying; Cong Rong; Yang Jie; Yu Hua

    2011-01-01

    The growing P2P streaming traffic brings a variety of problems and challenges to ISP networks and service providers.A P2P streaming traffic classification method based on sampling technology is presented in this paper.By analyzing traffic statistical features and network behavior of P2P streaming,a group of flow characteristics were found,which can make P2P streaming more recognizable among other applications.Attributes from Netflow and those proposed by us are compared in terms of classification accuracy,and so are the results of different sampling rates.It is proved that the unified classification model with the proposed attributes can identify P2P streaming quickly and efficiently in the online system.Even with 1∶50 sampling rate,the recognition accuracy can be higher than 94%.Moreover,we have evaluated the CPU resources,storage capacity and time consumption before and after the sampling,it is shown that the classification model after the sampling can significantly reduce the resource requirements with the same recognition accuracy.

  20. Monitoring autophagic flux using Ref(2)P, the Drosophila p62 ortholog.

    Science.gov (United States)

    DeVorkin, Lindsay; Gorski, Sharon M

    2014-09-02

    Human p62, also known as Sequestome-1 (SQSTM1), is a multifunctional scaffold protein that contains many domains, including a Phox/Bem1P (PB1) multimerization domain, an ubiquitin-associated (UBA) domain, and a light chain 3 (LC3) recognition sequence. p62 binds ubiquitinated proteins and targets them for degradation by the proteasome. In addition, p62 directly binds LC3; this may serve as a mechanism to deliver ubiquitinated proteins for degradation by autophagy. During this process, p62 itself is degraded. The inhibition of autophagy leads to the accumulation of p62, indicating that it can be used as a marker of autophagic flux. Ref(2)P (refractory to sigma P), the Drosophila ortholog of p62, is also required for the formation of ubiquitinated protein aggregates. Ref(2)P contains a putative LC3-interacting region, and genetic inhibition of autophagy in Drosophila leads to the accumulation of Ref(2)P protein levels. Thus, like p62, Ref(2)P may serve as a marker of autophagic flux. Here we provide two procedures to examine Ref(2)P protein levels in Drosophila ovaries.

  1. Synthesis, characterization and photocatalytic performance of PbS/Ni2P flowers

    Science.gov (United States)

    Liu, Shuling; Han, Lefang; Liu, Hui

    2016-11-01

    Flower-like PbS/Ni2P composites were synthesized by a facile two-step chemical route. The morphology and structure of the resulting composites were investigated by SEM and TEM images and XRD spectra, respectively. The results showed that the as-obtained composites were composed of the cubic PbS flowers and hexagonal Ni2P nanoparticles, and Ni2P nanoparticles coated on the surfaces of flower-like PbS microstructure. It was found that changing the molar ratio to 3:1, flower-like PbS/Ni2P composites have been successfully synthesized by using cationic cetyltrimethylammonium bromide(CTAB) and anionic sodium dodecyl sulfate (SDS) as template. Furthermore, using methylene blue(MB) as a model organic pollutant, the photocatalytic degradation experiments indicated that the as-prepared composites showed enhanced photocatalytic degradation activity for methylene blue(75%) which is as higher as that of the only flower-like PbS (16.6%) and only Ni2P nanoparticles (44.8%) at the same time. This work may be expected to find its potential application in water pollution treatment.

  2. An Efficient Architecture for Information Retrieval in P2P Context Using Hypergraph

    CERN Document Server

    Ismail, Anis; Durand, Nicolas; Hajjar, Mohammad

    2011-01-01

    Peer-to-peer (P2P) Data-sharing systems now generate a significant portion of Internet traffic. P2P systems have emerged as an accepted way to share enormous volumes of data. Needs for widely distributed information systems supporting virtual organizations have given rise to a new category of P2P systems called schema-based. In such systems each peer is a database management system in itself, ex-posing its own schema. In such a setting, the main objective is the efficient search across peer databases by processing each incoming query without overly consuming bandwidth. The usability of these systems depends on successful techniques to find and retrieve data; however, efficient and effective routing of content-based queries is an emerging problem in P2P networks. This work was attended as an attempt to motivate the use of mining algorithms in the P2P context may improve the significantly the efficiency of such methods. Our proposed method based respectively on combination of clustering with hypergraphs. We use...

  3. Information Exchange rather than Topology Awareness: Cooperation between P2P Overlay and Traffic Engineering

    Directory of Open Access Journals (Sweden)

    Jia Zhao

    2014-01-01

    Full Text Available Solutions to the routing strategic conflict between noncooperative P2P overlay and ISP underlay go separate ways: hyperselfishness and cooperation. Unpredictable (possibly adverse impact of the hyperselfish topology awareness, which is adopted in both overlay routing and traffic engineering, has not been sufficiently studied in the literature. Topology-related information exchange in a cooperatively efficient way should be highlighted to alleviate the cross-layer conflict. In this paper, we first illustrate the hyperselfish weakness with two dynamic noncooperative game models in which hyperselfish overlay or underlay has to accept a suboptimal profit. Then we build a synergistic cost-saving (SC game model to reduce the negative effects of noncooperation. In the SC model, through information exchange, that is, the classified path-delay metrics for P2P overlay and peer locations for underlay, P2P overlay selects proximity as well as saving traffic transit cost for underlay, and ISP underlay adjusts routing to optimize network cost as well as indicating short delay paths for P2P. Simulations based on the real and generated topologies validate cost improvement by SC model and find a proper remote threshold value to limit P2P traffic from remote area, cross-AS, or cross-ISP.

  4. MicroRNA-124-3p regulates cell proliferation, invasion, apoptosis, and bioenergetics by targeting PIM1 in astrocytoma.

    Science.gov (United States)

    Deng, Danni; Wang, Lei; Chen, Yao; Li, Bowen; Xue, Lian; Shao, Naiyuan; Wang, Qiang; Xia, Xiwei; Yang, Yilin; Zhi, Feng

    2016-07-01

    The PIM1 protein is an important regulator of cell proliferation, the cell cycle, apoptosis, and metabolism in various human cancers. MicroRNAs (miRNAs) are powerful post-transcriptional gene regulators that function through translational repression or transcript destabilization. Therefore, we aimed to identify whether a close relationship exists between PIM1 and miRNAs. PIM1 protein levels and mRNA levels were significantly upregulated in astrocytoma tissues, indicating the oncogenic role of PIM1 in astrocytoma. Further bioinformatics analysis indicated that miR-124-3p targeted the 3'-UTR of PIM1. We also observed an inverse correlation between the miR-124-3p levels and PIM1 protein or mRNA levels in astrocytoma samples. Next, we experimentally confirmed that miR-124-3p directly recognizes the 3'-UTR of the PIM1 transcript and regulates PIM1 expression at both the protein and mRNA levels. Furthermore, we examined the biological consequences of miR-124-3p targeting PIM1 in vitro. We showed that the repression of PIM1 in astrocytoma cancer cells by miR-124-3p suppressed proliferation, invasion, and aerobic glycolysis and promoted apoptosis. We observed that the restoration or inhibition of PIM1 activity resulted in effects that were similar to those induced by miR-124-3p inhibitors or mimics in cancer cells. Finally, overexpression of PIM1 rescued the inhibitory effects of miR-124-3p. In summary, these findings aid in understanding the tumor-suppressive role of miR-124-3p in astrocytoma pathogenesis through the inhibition of PIM1 translation. PMID:27088547

  5. Prm3p Is a Pheromone-induced Peripheral Nuclear Envelope Protein Required for Yeast Nuclear Fusion

    OpenAIRE

    Shen, Shu; Tobery, Cynthia E.; Rose, Mark D.

    2009-01-01

    Nuclear membrane fusion is the last step in the mating pathway of the yeast Saccharomyces cerevisiae. We adapted a bioinformatics approach to identify putative pheromone-induced membrane proteins potentially required for nuclear membrane fusion. One protein, Prm3p, was found to be required for nuclear membrane fusion; disruption of PRM3 caused a strong bilateral defect, in which nuclear congression was completed but fusion did not occur. Prm3p was localized to the nuclear envelope in pheromon...

  6. Theoretical study on the two-band degenerate-gaps superconductors: Application to SrPt3P

    Science.gov (United States)

    Huang, Hai; Hou, Li-Chao; Zhao, Bin-Peng

    2016-09-01

    We study the magnetic properties of two-band degenerate-gaps superconductors with two-band isotropic Ginzburg-Landau theory. The exact solutions of upper critical field and London penetration depth are obtained, and the calculations reproduce the experimental data of the recently observed superconducting crystal SrPt3P in a broad temperature range. It directly underlies that SrPt3P is a multi-band superconductor with equal gaps in two Fermi surface sheets.

  7. Research of the lime rich portions of the CaO-SiO2-P2O5 system

    Directory of Open Access Journals (Sweden)

    Puertas, F.

    1995-03-01

    Full Text Available A detailed study has been carried out to explain the influence of Pp^ in silicate phases and in industrial raw meals upon their mineralogical compositions. Some compositions in the lime rich portion of the CaO-SiO2-P2O5 system are studied using laboratory reactants. The results showed that the compositions lying in the range of CaO = 69,5-70,1; P2O5= 16,2-19,5; SiO2 = 11,1-13,6 (wt% give, at 1000 °C, the mineralogical composition (HAp, β-C2S, C5PS which can develop a high strength in chemically bonded ceramics. At high temperature (1400 ºC these compositions give a large amount of silicocarnotite (C5PS and 2C2.C3P phase. A selected composition of the industrial raw meal with added phosphate: CaO = 62,66; SiO2 -= 17,33; Al2O3 = 4,88; Fe2O3 = 4,29; P2O5 = 8,73; MgO = 2,09 (wt% forms at 1350 ºC a clinker containing high amount of α-C2S to replace C3S. Such a clinker may have good applications in the synthesis of active belite cement.Se estudia con detalle la influencia del P2O5 sobre las composiciones mineralógicas en fases silicato y en un crudo industrial. Asimismo se estudian algunas composiciones de la zona rica en cal del sistema CaO-SiO2-P2O5 utilizando reactivos químicos. Los resultados demuestran que, a presión atmosférica y recinto abierto, las composiciones dentro de los límites CaO = 69,5-70,1; P2O5= 16,2-19,5; SiO2 = 11,1-13,6 (% en peso dan a 1000ºC la composición mineralógica siguiente: HAp, β-C2S, C5PS; pueden desarrollar una alta resistencia química en "chemically bonded ceramics". A altas temperaturas (1400°C producen una elevada proporción de silicocarnotita (C5PS S y la fase 2C2.C3P. Con la adición de fosfato a una determinada dosificación de crudo industrial (CaO = 62,66; SiO2 = 17,33; Al2O3 = 4,88; Fe2O3 = 4,29; P2O5 = 8,73; MgO = 2,09 -% en peso- se forma, a 1350°C, un clinker que contiene una alta proporción de α-C2S que reemplaza al C3S. Este clinker puede tener buenas aplicaciones en la obtención de

  8. Analytical Modelling of Localized P2P Streaming Systems under NAT Consideration

    Directory of Open Access Journals (Sweden)

    Mohammad Z. M. Masoud

    2013-06-01

    Full Text Available NAT has been design to work with Internet client-server structure. The emerged of Peer-to-Peer (P2Pnetworks and applications revealed the incompatibility between P2P applications and NAT. Many methodshas been developed and implemented to solve connectivity between peers behind NAT devices.Nevertheless, various NATing types can’t communicate with one another. In this work, we are going tostudy the impact of NAT types on the start-up delay time of peers in P2P streaming systems. We willdemonstrate the ability of NATing to expel peers in P2P live streaming systems. A new neighbour selectingalgorithm will be proposed. This algorithm will utilize NAT-types configurations as a parameter. We haveutilized NS2 simulator to show the performance of the new algorithm in increasing the connectivity,reducing the number of expelled peers and implementing of locality.

  9. High-pressure elastic properties of cubic Ir2P from ab initio calculations

    Science.gov (United States)

    Sun, Xiao-Wei; Bioud, Nadhira; Fu, Zhi-Jian; Wei, Xiao-Ping; Song, Ting; Li, Zheng-Wei

    2016-10-01

    A study of the high-pressure elastic properties of new synthetic Ir2P in the anti-fluorite structure is conducted using ab initio calculations based on density functional theory. The elastic constants C11, C12 and C44 for the cubic Ir2P are obtained by the stress-strain method and the elastic stability calculations under pressure indicate that it is stable at least 100 GPa. Additionally, the electronic density of states, the aggregate elastic moduli, that is bulk modulus, shear modulus, and Young's modulus along with the Debye temperature, Poisson's ratio, and elastic anisotropy factor are all successfully obtained. Moreover, the pressure dependence of the longitudinal and shear wave velocities in three different directions [100], [110], and [111] for Ir2P are also predicted for the first time.

  10. Atypical features of a Ure2p glutathione transferase from Phanerochaete chrysosporium.

    Science.gov (United States)

    Thuillier, Anne; Roret, Thomas; Favier, Frédérique; Gelhaye, Eric; Jacquot, Jean-Pierre; Didierjean, Claude; Morel-Rouhier, Mélanie

    2013-07-11

    Glutathione transferases (GSTs) are known to transfer glutathione onto small hydrophobic molecules in detoxification reactions. The GST Ure2pB1 from Phanerochaete chrysosporium exhibits atypical features, i.e. the presence of two glutathione binding sites and a high affinity towards oxidized glutathione. Moreover, PcUre2pB1 is able to efficiently deglutathionylate GS-phenacylacetophenone. Catalysis is not mediated by the cysteines of the protein but rather by the one of glutathione and an asparagine residue plays a key role in glutathione stabilization. Interestingly PcUre2pB1 interacts in vitro with a GST of the omega class. These properties are discussed in the physiological context of wood degrading fungi.

  11. P2PRPIPS: A P2P and Reverse Proxy Based Web Intrusion Protection System

    Directory of Open Access Journals (Sweden)

    Qian He

    2013-03-01

    Full Text Available In order to protect web sites with various program languages and high throughput efficiently, a web Intrusion Protection System (IPS based on P2P and reverse proxy architecture was designed and implemented. The P2P based web intrusion protection system has multi web firewall nodes and nodes with same program cooperate with each other under P2P architecture. Some nodes work as net flow allocator and some work as detector and they can convert to each other according to the requirements dynamically. The WAF program has the characteristics of session keeping and load balancing and it can detect messages by using expert library and many plug-in components. The technology of reverse proxy is used for response the web request. Experiments show that the system can effectively prevent attacks form application layer. It is proved more efficient and stable than single node.

  12. 2P-Med: Building a Personalization Platform for Mediation Systems

    CERN Document Server

    Zaoui, Imane; Benhlima, Laila

    2011-01-01

    Nowadays, with the increasing number of integrated data sources, there is a real trend to personalize mediation systems to improve user satisfaction. To make these systems user sensitive, we propose a personalization platform called 2P-Med. 2P-Med allows personalizing any mediation system used in any domain following a cyclic process. The process includes building and managing adequate user profiles and sources profiles, content and quality matching, source selection, adapting the mediator responses to user preferences and handling user feedbacks. In this paper, we describe 2P-Med architecture and highlight its main functionalities. We also illustrate the operation of the platform through personalizing source selection in a travel planning assistant.

  13. A Group-oriented Access Control Scheme for P2P Networks

    Directory of Open Access Journals (Sweden)

    Wang Xiaoming

    2011-02-01

    Full Text Available A group-oriented access control scheme is proposed for P2P (peer to peer networks. In the proposed scheme, authentication control, admission control and revocation control are used in order to provide security services for P2P networks. Moreover, the proposed scheme can simply and efficient establish share key between two members without interactions, therefore it can perform secure communications with them. The analysis of security and performance shows that the proposed scheme not only can realize authentication and secure communication, but also can easily and efficiently add new group members and revoke malicious group members. Therefore, it is more efficient, and more practical protocol for P2P networks.

  14. Improved Optimal Searching Techniques in Distributed P2P networks using Guided Protocol Approach

    Directory of Open Access Journals (Sweden)

    S.Bhaskaran

    2009-12-01

    Full Text Available peer-to-peer (P2P networks establish looselycoupled application-level overlays on top of the Internetto facilitate efficient sharing of resources. They canbe roughly classified as either structured or unstructurednetworks. Without stringent constraints over the networktopology, unstructured P2P networks can be constructedvery efficiently and are therefore considered suitable tothe Internet environment. However, the random searchstrategies adopted by these networks usually performpoorly with a large network Size. In this paper, we seekto enhance the search performance in unstructured P2Pnetworks through exploiting users’ commoninterest patterns captured within a probability-theoreticframework based on DHT . A search protocol and arouting table updating protocol are further proposed inorder to expedite the search process through selforganizing the P2P network into a small world.

  15. Supporting K nearest neighbors query on high-dimensional data in P2P systems

    Institute of Scientific and Technical Information of China (English)

    Mei LI; Wang-Chien LEE; Anand SIVASUBRAMANIAM; Jizhong ZHAO

    2008-01-01

    Peer-to-peer systems have been widely used for sharing and exchanging data and resources among numerous computer nodes.Various data objects identifiable with high dimensional feature vectors,such as text,images,genome sequences,are starting to leverage P2P technology.Most of the existing works have been focusing on queries on data objects with one or few attributes and thus are not applicable on high dimensional data objects.In this study,we investigate K nearest neighbors query (KNN)on high dimensional data objects in P2P systems.Efficient query algorithm and solutions that address various technical challenges raised by high dimensionality,such as search space resolution and incremental search space refinement,are proposed.An extensive simulation using both synthetic and real data sets demonstrates that our proposal efficiently supports KNN query on high dimensional data in P2P systems.

  16. Kinetic-arrest-induced phase coexistence and metastability in (Mn,Fe ) 2(P ,Si )

    Science.gov (United States)

    Miao, X. F.; Mitsui, Y.; Dugulan, A. Iulian; Caron, L.; Thang, N. V.; Manuel, P.; Koyama, K.; Takahashi, K.; van Dijk, N. H.; Brück, E.

    2016-09-01

    Neutron diffraction, Mössbauer spectroscopy, magnetometry, and in-field x-ray diffraction are employed to investigate the magnetoelastic phase transition in hexagonal (Mn,Fe ) 2(P ,Si ) compounds. (Mn,Fe ) 2(P ,Si ) compounds undergo for certain compositions a second-order paramagnetic (PM) to a spin-density-wave (SDW) phase transition before further transforming into a ferromagnetic (FM) phase via a first-order phase transition. The SDW-FM transition can be kinetically arrested, causing the coexistence of FM and untransformed SDW phases at low temperatures. Our in-field x-ray diffraction and magnetic relaxation measurements clearly reveal the metastability of the untransformed SDW phase. This unusual magnetic configuration originates from the strong magnetoelastic coupling and the mixed magnetism in hexagonal (Mn,Fe ) 2(P ,Si ) compounds.

  17. A P2P Botnet Virus Detection System Based on Data-Mining Algorithms

    Directory of Open Access Journals (Sweden)

    Wernhuar Tarng

    2012-11-01

    Full Text Available A P2P botnet virus detection system based on data-mining algorithms is proposed in this study to detect theinfected computers quickly using Bayes Classifier and Neural Network (NN Classifier. The system candetect P2P botnet viruses in the early stage of infection and report to network managers to avoid furtherinfection. The system adopts real-time flow identification techniques to detect traffic flows produced by P2Papplication programs and botnet viruses by comparing with the known flow patterns in the database. Aftertrained by adjusting the system parameters using test samples, the experimental results show that theaccuracy of Bayes Classifier is 95.78% and that of NN Classifier is 98.71% in detecting P2P botnet virusesand suspected flows to achieve the goal of infection control in a short time.

  18. On the Design and Implementation of Structured P2P VPNs

    CERN Document Server

    Wolinsky, David Isaac; Lee, Kyungyong; Liu, Yonggang; Xu, Jiangyan; Boykin, P Oscar; Figueiredo, Renato

    2010-01-01

    Centralized Virtual Private Networks (VPNs) when used in distributed systems have performance constraints as all traffic must traverse through a central server. In recent years, there has been a paradigm shift towards the use of P2P in VPNs to alleviate pressure placed upon the central server by allowing participants to communicate directly with each other, relegating the server to handling session management and supporting NAT traversal using relays when necessary. Another, less common, approach uses unstructured P2P systems to remove all centralization from the VPN. These approaches currently lack the depth in security options provided by other VPN solutions, and their scalability constraints have not been well studied. In this paper, we propose and implement a novel VPN architecture, which uses a structured P2P system for peer discovery, session management, NAT traversal, and autonomic relay selection and a central server as a partially-automated public key infrastructure (PKI) via a user-friendly web inte...

  19. Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxel.

    Science.gov (United States)

    Tambe, Mahesh; Pruikkonen, Sofia; Mäki-Jouppila, Jenni; Chen, Ping; Elgaaen, Bente Vilming; Straume, Anne Hege; Huhtinen, Kaisa; Cárpen, Olli; Lønning, Per Eystein; Davidson, Ben; Hautaniemi, Sampsa; Kallio, Marko J

    2016-03-15

    The molecular pathways that contribute to the proliferation and drug response of cancer cells are highly complex and currently insufficiently characterized. We have identified a previously unknown microRNA-based mechanism that provides cancer cells means to stimulate tumorigenesis via increased genomic instability and, at the same time, evade the action of clinically utilized microtubule drugs. We demonstrate miR-493-3p to be a novel negative regulator of mitotic arrest deficient-2 (MAD2), an essential component of the spindle assembly checkpoint that monitors the fidelity of chromosome segregation. The microRNA targets the 3' UTR of Mad2 mRNA thereby preventing translation of the Mad2 protein. In cancer cells, overexpression of miR-493-3p induced a premature mitotic exit that led to increased frequency of aneuploidy and cellular senescence in the progeny cells. Importantly, excess of the miR-493-3p conferred resistance of cancer cells to microtubule drugs. In human neoplasms, miR-493-3p and Mad2 expression alterations correlated with advanced ovarian cancer forms and high miR-493-3p levels were associated with reduced survival of ovarian and breast cancer patients with aggressive tumors, especially in the paclitaxel therapy arm. Our results suggest that intratumoral profiling of miR-493-3p and Mad2 levels can have diagnostic value in predicting the efficacy of taxane chemotherapy. PMID:26943585

  20. MiR-525-3p enhances the migration and invasion of liver cancer cells by downregulating ZNF395.

    Directory of Open Access Journals (Sweden)

    Fei Pang

    Full Text Available Liver cancer is one of leading causes of cancer-related deaths. A deeper mechanistic understanding of liver cancer could lead to the development of more effective therapeutic strategies. In our previous work, we screened 646 miRNAs and identified 11 that regulate liver cancer cell migration. The current study shows that miR-525-3p is frequently up-regulated in liver cancer tissues, and enhanced expression of miR-525-3p can promote liver cancer cell migration and invasion. Zinc finger protein 395 (ZNF395 is the direct functional target gene for miR-525-3p, and it is frequently down-regulated in liver cancer tissues. High expression of ZNF395 can significantly inhibit while knockdown of ZNF395 expression can markedly enhance the migration and invasion of liver cancer cells, suggesting that ZNF395 suppresses metastasis in liver cancer. Down-regulation of ZNF395 can mediate miR-525-3p induced liver cancer cell migration and invasion. In conclusion, miR-525-3p promotes liver cancer cell migration and invasion by directly targeting ZNF395, and the fact that miR-525-3p and ZNF395 both play important roles in liver cancer progression makes them potential therapeutic targets.

  1. Bitcoin Virtual Currency Analysis Based on P2P%基于 P2P 网络的 Bitcoin 虚拟货币分析

    Institute of Scientific and Technical Information of China (English)

    石苗; 李宥谋

    2015-01-01

    Bitcoin is an anonymous digital cash based on P2P network .In this paper ,starting from the development present situation of the network virtual currency ,detailed analysis formation related technical principles and transaction process and the authentication mechanism from the technical level of Bitcoin ,affirmed its historical and revolutionary .At the same time ,aspects of problems of Bitcoin are analyzed ,its importance in the network virtual currency unification is explored .%Bitcoin 是一种基于 P2P 网络的匿名数字货币,论文从网络虚拟货币的发展现状出发,从技术层面详细分析Bitcoin 形成相关技术原理及其交易过程和验证机制,肯定了其历史性和革命性。同时分析 Bitcoin 存在的各方面问题,探究其在网络虚拟货币统一方面的重要借鉴意义。

  2. Excitation of the (2p2)1D and (2s2p)1P autoionizing states of helium by 200 eV electron impact

    International Nuclear Information System (INIS)

    We report full second Born calculations with inclusion of post-collision interactions for excitation of the (2p2)1D and (2s2p)1P autoionizing states of helium by 200 eV electron impact. The calculations are compared to (e, 2e) measurements of McDonald and Crowe (McDonald D G and Crowe A 1993 J. Phys. B: At. Mol. Opt. Phys. 26 2887-97) and Lower and Weigold (Lower J and Weigold E 1990 J. Phys. B: At. Mol. Opt. Phys. 23 2819-45). It is shown that post-collision interactions or Coulomb interactions in the final state between the scattered particle, the ejected electron and the recoil ion have a strong influence on both the direct ionization and resonance profiles around the binary lobe. The second-order terms in the amplitude of double electron excitation also play an observable role under these kinematic conditions. Reasonable agreement is found between the full-scale calculations and the experimental data. (author). Letter-to-the-editor

  3. Complexes of (EtO){sub 2}P(O)CH{sub 2}P(O)(OEt){sub 2} with lanthanide nitrates

    Energy Technology Data Exchange (ETDEWEB)

    Lees, A.M.J.; Platt, A.W.G. [Staffordshire Univ., School of Sciences, College Road, Stoke-on-Trent (United Kingdom); Kresinski, A. [Kingston Univ., School of Chemical and Pharmaceutical Sciences (United Kingdom)

    2004-12-01

    The preparation of complexes of (EtO){sub 2}P(O)CH{sub 2}P(O)(OEt){sub 2} = L, with lanthanide nitrates is described. Stable complexes with composition LnL{sub 2}(NO{sub 3}){sub 3} can be isolated for Ln = La-Eu and fully characterised. For LnGd-Lu solid compounds could not be isolated. Conductivity and {sup 31}P NMR spectroscopy indicate structural changes in solution between the lighter and heavier lanthanides and, whilst electro-spray mass spectrometry confirms a dramatic difference in behaviour with complexes of the heavier lanthanides readily decomposing via loss of EtNO{sub 3}, other experiments show that this does not occur under the conditions of complex formation. The single crystal X-ray structures for Ln = La and Sm show the nitrates and OEt groups to be in close proximity. The changes in spectroscopic properties correlate well with the difficulties in isolating the complexes of heavier metals, and are possibly due to the formation of dimeric complexes rather than loss of ethyl nitrate. (authors)

  4. 基于 P2P 网络的 Bitcoin 虚拟货币分析%Bitcoin Virtual Currency Analysis Based on P2P

    Institute of Scientific and Technical Information of China (English)

    石苗; 李宥谋

    2015-01-01

    Bitcoin 是一种基于 P2P 网络的匿名数字货币,论文从网络虚拟货币的发展现状出发,从技术层面详细分析Bitcoin 形成相关技术原理及其交易过程和验证机制,肯定了其历史性和革命性。同时分析 Bitcoin 存在的各方面问题,探究其在网络虚拟货币统一方面的重要借鉴意义。%Bitcoin is an anonymous digital cash based on P2P network .In this paper ,starting from the development present situation of the network virtual currency ,detailed analysis formation related technical principles and transaction process and the authentication mechanism from the technical level of Bitcoin ,affirmed its historical and revolutionary .At the same time ,aspects of problems of Bitcoin are analyzed ,its importance in the network virtual currency unification is explored .

  5. Chemical preparation, kinetics of thermal behavior and infrared studies of Pb3(P3O92.3H2O and Cd3(P3O92.14H2O

    Directory of Open Access Journals (Sweden)

    Said Belaaouad

    2013-05-01

    Full Text Available Chemical preparation, thermal behavior, kinetic and IR studies are given for the cyclotriphosphates Pb3(P3O92.3H2O and Cd3(P3O92.14H2O. The later cyclotriphosphates have never been studied except their crystallographic characterization and are stable in the conditions of temperature and pressure of our laboratory until 343K. The final products of the dehydration and calcination of Pb3(P3O92.3H2O and Cd3(P3O92.14H2O, under atmospheric pressure, are respectively their long chain polyphosphates, [Pb(PO32]∞ and β[Cd(PO32]∞. The intermediate product of the dehydration of Cd3(P3O92.14H2O, under atmospheric pressure, is its long chain polyphosphate form α, α[Cd(PO32]. [Pb(PO32]∞ and β[Cd(PO32]∞ are stable until their melting points at respectively 946K and 1153K. Two different methods, Ozawa and KAS have been selected in order to study the kinetics of thermal behavior of the cyclotriphosphates Pb3(P3O92.3H2O and Cd3(P3O92.14H2O for the first time. The kinetic and thermodynamic features of the dehydration, of the cited cyclotriphosphates, were determined and discussed on the basis of their crystalline structure. [Pb(PO32]∞, α[Cd(PO32] and β[Cd(PO32] have many applications in industry such as corrosion inhibitors.

  6. Relationship between miRNA-338-3p expression and progression and prognosis of human colorectal carcinoma

    Institute of Scientific and Technical Information of China (English)

    Sun Kai; Su Guiyuan; Deng Haijun; Dong Jingqing; Lei Shangtong; Li Guoxin

    2014-01-01

    Background miR-338-3p is a recently discovered miRNA and is involved in cell differentiation.However,few data are yet available on the aberrant expression of miR-338-3p in human colorectal carcinoma (CRC).This work aimed to investigate the relationship between miR-338-3p expression pattern and clinicopathological features of human CRC and the possible regulative mechanisms.Methods The 40 CRC,adjacent nontumorous tissues and 2 human CRC-derived cell lines (SW-480 and SW-620) were collected,respectively,and the total RNA and protein were isolated routinely.The miR-338-3p expression pattern was detected by real-time reverse transcription-polymerase chain reaction (RT-PCR) and Northern blotting.Smoothened (SMO,possible target of miR-338-3p) mRNA and corresponding protein expression pattern were detected by semiquantitative RT-PCR and Western blotting.miR-338-3p expression patterns were compared between nontumor mucosa and CRC samples,graded by progression-related factors.Disease outcome was calculated by Kaplan-Meier survival analysis to determine whether miR-338-3p was related to disease-free survival (DFS) and overall survival (OS) of patients.Moreover,SMO 3'-UTR fragment was PCR amplified from genome DNA of human colon and inserted into a luciferase reporter plasmid.The luciferase reporter plasmid construct was then transfected into CRC cells together with pre-miR-338-3p or anti-miR-338-3p and the luciferase activity in the transfected cells was detected.Results The expression of miR-338-3p was significantly downregulated in CRCs than those in the adjacent nontumorous tissues,and the value was negatively related to advanced TNM stage and local invasion (P <0.01).Furthermore,miR338-3p value was decreased markedly in SW-620 cell line relative to SW-480 (P <0.01).Low expression of miR-338-3p was associated with unfavorable outcome in DFS but not in OS independent of clinical covariates.Moreover,RT-PCR and Western blotting analysis demonstrated that there was no

  7. Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe

    OpenAIRE

    She, Meipei; Decker, Carolyn J.; Chen, Nan; Tumati, Suneeta; Parker, Roy; Song, Haiwei

    2005-01-01

    Decapping is a key step in both general and nonsense-mediated 5′ → ′ mRNA-decay pathways. Removal of the cap structure is catalyzed by the Dcp1–Dcp2 complex. The crystal structure of a C-terminally truncated Schizosaccharomyces pombe Dcp2p reveals two distinct domains: an all-helical N-terminal domain and a C-terminal domain that is a classic Nudix fold. The C-terminal domain of both Saccharomyces cerevisiae and S. pombe Dcp2p proteins is sufficient for decapping activity, although the N-term...

  8. Si/SiO2/p-Si结构的电学特性

    Institute of Scientific and Technical Information of China (English)

    马自军; 马书懿

    2008-01-01

    用射频磁控溅射法在p-Si衬底上制备了Si/SiO2薄膜,利用Au/(Si/SiO2)/p-Si结构的I-V特性曲线对其电学特性进行了分析.结果表明,样品具有很好的整流作用,起整流作用的势垒存在于(Si/SiO2)/p-Si界面附近.

  9. Enabling Co-located Learning over Mobile Ad Hoc P2P with LightPeers

    Directory of Open Access Journals (Sweden)

    Bent Guldbjerg Christensen

    2008-02-01

    Full Text Available This paper presents LightPeers – a new mobile P2P framework specifically tailored for use in a nomadic learning environment. A set of key requirements for the framework is identified based on nomadic learning, and these requirements are used as outset for designing and implementing the architecture and protocols. The main contributions of the LightPeers framework are: a mobile P2P framework including a specialized robust messaging protocol resilient to changes in the network topology, an developers API, and a suite of LightPeers applications supporting nomadic learning prototyping key features of LightPeers.

  10. Photoionization of Ge13+ in the Inner-Shell 2p Excitation Energy Region

    Institute of Scientific and Technical Information of China (English)

    LIANG Gui-Yun; ZHAO Gang

    2006-01-01

    The photoionization cross sections of the levels belonging to the ground configuration [Ne]3s23p63d of Ge13+ are investigated using the fully relativistic R-matrix method in the 2p-3d excitation region.The photoionization cross section is dominated by 2p-3d resonances.The detailed resonance structures are described and analysed with the resonance positions,widths and oscillator strengths to be determined.Good agreement is obtained between the length and velocity forms of the resonallce oscillator strengths.The relative difference is less than 8%.

  11. A Participation-Based Trust Model for Mobile P2P Networks

    Directory of Open Access Journals (Sweden)

    Kai Liu

    2014-07-01

    Full Text Available Mobile peer-to-peer (P2P networks have become increasingly popular, but the attacks and selfness of peers make it vulnerable. In this paper, a trust model based on participation is proposed for mobile P2P networks (called ParticipationTrust. It could deal with the egoistic and malicious behaviors. And the level of peer’s participation could be calculated through the transaction participation and recommendation participation. A set of experiments show that the model is rational and effective

  12. HilbertChord: A Kind of Method for Managing Service Resources in P2P

    Institute of Scientific and Technical Information of China (English)

    SHAO Yi-chuan; SHEN De-rong; ZHAO Hong-wei

    2009-01-01

    According to the deficiency of Chord algorithm supporting single keyword query only,a P2P framework-HilbertChord by combining the Hilbert curve and Chord is proposed for managing grid service resources,which supports DHT-based multi-keyword query and approximate query by means of Hilbert index to improve resources searching ability.Experiments show that HilbertChord has better efficiency and scalability for managing service resources under the large scale P2P environment with higher density of services.

  13. Enabling Co-located Learning over Mobile Ad Hoc P2P with LightPeers

    DEFF Research Database (Denmark)

    Christensen, Bent Guldbjerg; Kristensen, Mads Darø; Hansen, Frank Allan;

    2008-01-01

    and protocols. The main contributions of the LightPeers framework are: a mobile P2P framework including a specialized robust messaging protocol resilient to changes in the network topology, an developers API, and a suite of LightPeers applications supporting nomadic learning prototyping key features of LightPeers.......This paper presents LightPeers – a new mobile P2P framework specifically tailored for use in a nomadic learning environment. A set of key requirements for the framework is identified based on nomadic learning, and these requirements are used as outset for designing and implementing the architecture...

  14. Quantum electrodynamics corrections to the 2P fine splitting in Li.

    Science.gov (United States)

    Puchalski, Mariusz; Pachucki, Krzysztof

    2014-08-15

    We consider quantum electrodynamics (QED) corrections to the fine splitting E(2P_{3/2})-E(2P_{1/2}) in the Li atom. We derive complete formulas for the mα^{6} and mα^{7}lnα contributions and calculate them numerically using highly optimized, explicitly correlated basis functions. The obtained results are in agreement with the most recent measurement, helping to resolve discrepancies between former ones and lay the foundation for the investigation of QED effects in light, many-electron atoms.

  15. A Survey and Synthesis of User Behavior Measurements in P2P Streaming Systems

    OpenAIRE

    Ullah, Ihsan; Doyen, Guillaume; Bonnet, Grégory; Gaïti, Dominique

    2012-01-01

    International audience In terms of scalability, cost and ease of deployment, the Peer-to-Peer (P2P) approach has emerged as a promising solution for video streaming applications. Its architecture enables end-hosts, called peers, to relay the video stream to each ot her. P2P systems are in fact networks of users who control peers. Thus, user behavior is crucial to the performance of these systems because it directly impacts the streaming flow. To understand user behavior, several measuremen...

  16. Cluster based hierarchical resource searching model in P2P network

    Institute of Scientific and Technical Information of China (English)

    Yang Ruijuan; Liu Jian; Tian Jingwen

    2007-01-01

    For the problem of large network load generated by the Gnutella resource-searching model in Peer to Peer (P2P) network, a improved model to decrease the network expense is proposed, which establishes a duster in P2P network,auto-organizes logical layers, and applies a hybrid mechanism of directional searching and flooding. The performance analysis and simulation results show that the proposed hierarchical searching model has availably reduced the generated message load and that its searching-response time performance is as fairly good as that of the Gnutella model.

  17. Structure and Function of the PLAA/Ufd3-p97/Cdc48 Complex

    Energy Technology Data Exchange (ETDEWEB)

    Qiu, Liyan; Pashkova, Natasha; Walker, John R.; Winistorfer, Stanley; Allali-Hassani, Abdellah; Akutsu, Masato; Piper, Robert; Dhe-Paganon, Sirano (Iowa); (Toronto)

    2010-02-11

    PLAA (ortholog of yeast Doa1/Ufd3, also know as human PLAP or phospholipase A2-activating protein) has been implicated in a variety of disparate biological processes that involve the ubiquitin system. It is linked to the maintenance of ubiquitin levels, but the mechanism by which it accomplishes this is unclear. The C-terminal PUL (PLAP, Ufd3p, and Lub1p) domain of PLAA binds p97, an AAA ATPase, which among other functions helps transfer ubiquitinated proteins to the proteasome for degradation. In yeast, loss of Doa1 is suppressed by altering p97/Cdc48 function indicating that physical interaction between PLAA and p97 is functionally important. Although the overall regions of interaction between these proteins are known, the structural basis has been unavailable. We solved the high resolution crystal structure of the p97-PLAA complex showing that the PUL domain forms a 6-mer Armadillo-containing domain. Its N-terminal extension folds back onto the inner curvature forming a deep ridge that is positively charged with residues that are phylogenetically conserved. The C terminus of p97 binds in this ridge, where the side chain of p97-Tyr805, implicated in phosphorylation-dependent regulation, is buried. Expressed in doa1{Delta} null cells, point mutants of the yeast ortholog Doa1 that disrupt this interaction display slightly reduced ubiquitin levels, but unlike doa1{Delta} null cells, showed only some of the growth phenotypes. These data suggest that the p97-PLAA interaction is important for a subset of PLAA-dependent biological processes and provides a framework to better understand the role of these complex molecules in the ubiquitin system.

  18. Identification of miR-140-3p as a marker associated with poor prognosis in spinal chordoma

    Science.gov (United States)

    Zou, Ming-Xiang; Huang, Wei; Wang, Xiao-Bin; Lv, Guo-Hua; Li, Jing; Deng, You-Wen

    2014-01-01

    Objective: To investigate the expression profile of miR-140-3p in formalin-fixed paraffin-embedded (FFPE) tissues of spinal chordoma, and its correlation with the prognosis of spinal chordoma patients. Methods: Dysregulated miRNAs in FFPE tissues of spinal chordoma were identified by microarray analysis. MiR-140-3p expression in surgically removed spinal chordoma tissues of 42 spinal chordoma patients (27 males and 15 females, aged 29-76 years) and corresponding nucleus pulposus tissues of 14 patients with disc herniation as the healthy control group (8 males and 6 females, aged 24-73 years) was measured by real-time quantitative RT-PCR assay. The association of miR-140-3p expression with clinicopathologic characteristics of spinal chordoma patients was analyzed. Additionally, we investigated the prognostic significance of miR-140-3p with the use of Kaplan-Meier methods and a Cox proportional hazard model. Results: The expression of miR-140-3p was significantly higher in chordoma tissues than nucleus pulposus tissues (t = 3.530, P = 0.001). The expression of miR-140-3p positively correlated with surrounding muscle invasion. The Kapan-Meier survival analysis showed that the patients with high miR-140-3p expression had a significantly worse recurrence-free survival than those with a low expression (χ 2 = 31.270, P = 0.000, log-rank test). In addition, univariate and multivariate analyses for recurrence-free survival showed that miR-140-3p expression was an independent prognostic factor for patients with spinal chordoma (HR = 1.361, 95% CI: 1.135-1.633, P = 0.001). Conclusion: Over-expression of miR-140-3p is correlated with recurrence and tumor invasion, suggesting that miR-140-3p could be a new predictor for recurrence and prognosis in patients with spinal chordoma. PMID:25197358

  19. Crystal structure and magnetic properties of the Ba3TeCo3P2O14, Pb3TeCo3P2O14, and Pb3TeCo3V2O14 langasites

    DEFF Research Database (Denmark)

    Krizan, J.W.; de la Cruz, C.; Andersen, Niels Hessel;

    2013-01-01

    We report the structural and magnetic characterizations of Ba3TeCo3P2O14, Pb3TeCo3P2O14, and Pb3TeCo3V2O14, compounds that are based on the mineral dugganite, which is isostructural to langasites. The magnetic part of the structure consists of layers of Co2+ triangles. Nuclear and magnetic...... of the three compounds studied along with the zinc analog Pb3TeZn3P2O14, also characterized here, suggests that the distortion is driven by Pb2+ lone pairs; as such, the Pb compounds crystallize in a pyroelectric space group, P2. Magnetic susceptibility, magnetization, and heat capacity measurements were...... performed to characterize the magnetic behavior. All three compounds become antiferromagnetic with Néel temperatures TN≈21K (Ba3TeCo3P2O14), ≈13K (Pb3TeCo3P2O14), and ≈8K (Pb3TeCo3V2O14), and they exhibit magnetic transitions at high applied magnetic fields, suggesting intrinsically complex magnetic...

  20. Up- regulation of miR-328-3p sensitizes non-small cell lung cancer to radiotherapy.

    Science.gov (United States)

    Ma, Wei; Ma, Chao-Nan; Zhou, Nan-Nan; Li, Xian-Dong; Zhang, Yi-Jie

    2016-01-01

    MicroRNAs (miRNAs) are believed to be resistant against radiotherapy in certain types of cancers. The aim of our study was to determine the clinical application of miRNAs in non-small cell lung cancer (NSCLC). Sixty NSCLC tissue samples and adjacent histologically normal tissues were obtained for miRNAs microarray analysis and validated by RT-qPCR. Correlation between miRNA expression level and clinicopathological features was evaluated. Our study examined the influence of changed miRNA expression on the damaged DNA and its associated radio sensitivity. Luciferase assay was performed to determine potential effects on the targeted gene. Our study identified fifteen altered miRNAs in which miR-328-3p was down regulated in NSCLC tumour tissue as compared to normal tissues. Down-expression of miR-328-3p was positively associated with an enhanced lymph node metastasis, advanced clinical stage and a shortened survival rate. miR-328-3p expression was decreased in A549 cells compared to other NSCLC cell lines. Up-regulation of miR-328-3p demonstrated a survival inhibition effect in A549 and restored NSCLC cells' sensitivity to radio therapy. An increased miR-328-3p expression promoted irradiation-induced DNA damage in cells. γ-H2AX was identified as the direct target of miR-328-3p. Over-expressed miR-328-3p can improve the radiosensitvity of cells by altering the DNA damage/repair signalling pathways in NSCLC. PMID:27530148

  1. Implementation of P2P Reputation Management Using Distributed Identities and Decentralized Recommendation Chains

    Directory of Open Access Journals (Sweden)

    P.Satheesh

    2012-06-01

    Full Text Available In this paper, we investigate Reputation Systems for P2P networks more ambitious approach to protect the P2P network without using any central component, and thereby harnessing the full benefits of the P2P network. The reputations of the peers are used to determine whether a peer is a malicious peer or a good peer. Once detected, the malicious peers are ostracized from the network as the good peers do not perform any transactions with the malicious peers. Expulsion of malicious peers from the network significantly reduces the volume of malicious activities. All peers in the P2P network are identified by identity certificates. The reputation of a given peer is attached to its identity. The identity certificates are generated using self-certification, and all peers maintain their own certificate authority which issues the identity certificates to the peer. Each peer owns the reputation information pertaining to all its past transactions with other peers in the network, and stores it locally. A two-party cryptographic protocol not only protects the reputation information from its owner, but also facilitates secure exchange of reputation information between the two peers participating in a transaction

  2. Erv2p: characterization of the redox behavior of a yeast sulfhydryl oxidase

    DEFF Research Database (Denmark)

    Wang, Wenzhong; Winther, Jakob R; Thorpe, Colin

    2007-01-01

    and with unfolded proteins. Rapid reaction studies confirm that reduction of the flavin center of Erv2p is rate-limiting during turnover with molecular oxygen. This comparison of the redox properties between members of the ERV/ALR family of sulfhydryl oxidases provides insights into their likely roles in oxidative...... protein folding. Udgivelsesdato: 2007-Mar-20...

  3. Recent Replica Placement Algorithms in P2P Networks – A Review

    Directory of Open Access Journals (Sweden)

    Kala Karun. A

    2013-04-01

    Full Text Available Peer-to-Peer (P2P systems provide a platform for large internet scale distributed applications with no dedicated infrastructure. In P2P systems, applications are developed by dividing them across individual systems termed peers which take the role of both client as well as server. Popularity of objects in such a system can change rapidly, which demands the need for a rapid and light weight content replication strategy which considers this dynamic popularity changes. While considering P2P in distributed file sharing applications, data availability has significant impact on the system's performance. In addition to optimized availability, the replica placement should guarantee reduced search and data access latency. It should be dynamically adaptable to instantaneous query arrival rate as well as dynamic membership of individual peers. Also, it should provide good performance with reduced number of control messages. Thus an intelligent placement of replicas considering various factors of the system always outperforms a random placement of replicas on random peers. This paper reviews and compares various recent replica placement algorithms for structured as well as unstructured P2P networks.

  4. Electronic Structure and Optical Properties Of EuIn2P2

    KAUST Repository

    Singh, Nirpendra

    2011-10-25

    The electronic structures and, optical and magneto‐optical properties of a newly found Zintl compound EuIn2P2 have been investigated within the density‐functional theory using the highly precise full‐potential linear‐augmented‐plane‐wave method. Results of detailed investigation of the electronic structure and related properties are reported.

  5. Characterization of a recurrent t(1;2)(p36;p24) in human uterine leiomyoma.

    NARCIS (Netherlands)

    Rijk, A. van; Sweers, M.A.; Huys, E.; Kersten, M.; Merkx, G.F.M.; Geurts van Kessel, A.H.M.; Debiec-Rychter, M.; Schoenmakers, E.F.P.M.

    2009-01-01

    Uterine leiomyomas are the most common neoplasms in women of reproductive age. Approximately 40% of these neoplasms show recurring structural cytogenetic anomalies, including del(7)(q22), t(12;14)(q15;q24), t(1;2)(p36;p24), and anomalies affecting 6p21 or 10q22. Using positional cloning strategies,

  6. Scaling laws for file dissemination in P2P networks with random contacts

    NARCIS (Netherlands)

    Nunez-Queija, R.; Prabhu, B.

    2008-01-01

    In this paper we obtain the scaling law for the mean broadcast time of a file in a P2P network with an initial population of N nodes. In the model, at Poisson rate λ a node initiates a contact with another node chosen uniformly at random. This contact is said to be successful if the contacted node p

  7. Identifying file-sharing P2P traffic based on traffic characteristics

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    This article focuses on identifying file-sharing peer-to-peer (P2P) (such as BitTorrent (BT)) traffic at the borders of a stub network. By analyzing protocols and traffic of applications, it is found that file-sharing P2P traffic of a single user differs greatly from traditional and other P2P (such as QQ) applications' traffic in the distribution of involved remote hosts and remote ports. Therefore, a method based on discreteness of remote hosts (RHD) and discreteness of remote ports (RPD) is proposed to identify BT-like traffic. This method only relies on flow information of each user host in a stub network, and no packet payload needs to be monitored. At intervals, instant RHD for concurrent transmission control protocol and user datagram protocol flows for each host are calculated respectively through grouping flows by the stub network that the remote host of each flow belongs to. On given conditions, instant RPD are calculated through grouping flows by the remote port to amend instant RHD. Whether a host has been using a BT-like application or not can be deduced from instant RHD or average RHD for a period of time. The proposed method based on traffic characteristics is more suitable for identifying protean file-sharing P2P traffic than content-based methods. Experimental results show that this method is effective with high accuracy.

  8. NEUT development for T2K and relevance of updated 2p2h models

    CERN Document Server

    Wilkinson, Callum

    2015-01-01

    The MiniBooNE large axial-mass anomaly has motivated the development of new theoretical Charged Current Quasi-Elastic (CCQE) cross-section models in recent years. These proceedings review the development of the neutrino simulation generator NEUT to incorporate these more sophisticated CCQE models, including multi-nucleon interaction (2p2h) effects. The fit results on the MINER$\

  9. Electrical properties of the anisotropic n-ТiО2/P-CdTe heterojunctions

    OpenAIRE

    Брус, Віктор Васильович; Ілащук, Марія Іванівна; Ковалюк, Захар Дмитрович; Мар’янчук, Павло Дмитрович; Ульяницький, Костянтин Сергійович; Кафанов, Анатолій Михайлович

    2012-01-01

    The electrical properties of the n-ТіО2/p-CdTe, prepared by deposition of TiO2 film onto freshly cleaved CdTe single crystal substrates were investigated. The electric current in the heterojunctions is induced by generation-recombination processes within the depletion region and tunneling of carriers

  10. Database selection and result merging in P2P web search

    NARCIS (Netherlands)

    Chernov, S.; Serdyukov, P.; Bender, M.; Michel, S.; Weikum, G.; Zimmer, C.

    2005-01-01

    Intelligent Web search engines are extremely popular now. Currently, only the commercial centralized search engines like Google can process terabytes of Web data. Alternative search engines fulfilling collaborative Web search on a voluntary basis are usually based on a blooming Peer-to-Peer (P2P) te

  11. Scaling laws for file dissemination in P2P networks with random contacts

    NARCIS (Netherlands)

    R. Núñez-Queija; B. Prabhu

    2008-01-01

    In this paper we obtain the scaling law for the mean broadcast time of a file in a P2P network with an initial population of N nodes. In the model, at Poisson rate lambda a node initiates a contact with another node chosen uniformly at random. This contact is said to be successful if the contacted n

  12. 76 FR 65558 - Rescission of Social Security Ruling 97-2p

    Science.gov (United States)

    2011-10-21

    ... toll-free number, 1-800-772-1213 or TTY 1-800-325-0778, or visit our Internet site, Social Security... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Rescission of Social Security Ruling 97-2p AGENCY: Social Security Administration. ACTION:...

  13. SemTrust: A Semantic Reputation System in P2P-Based Semantic Web

    Institute of Scientific and Technical Information of China (English)

    WANG Wei; ZENG Guosun; YUAN Lulai

    2006-01-01

    A reputation mechanism is introduced in P2P-based Semantic Web to solve the problem of lacking trust. It enables Semantic Web to utilize reputation information based on semantic similarity of peers in the network. This approach is evaluated in a simulation of a content sharing system and the experiments show that the system with reputation mechanism outperforms the system without it.

  14. Traceable P2P record exchange: a database-oriented approach

    Institute of Scientific and Technical Information of China (English)

    Fengrong LI; Takuya IIDA; Yoshiharu ISHIKAWA

    2008-01-01

    In recent years,peer-to-peer (P2P) technologies are used for flexible and scalable information exchange in the Internet,but there exist problems to be solved for reliable information exchange.It is important to trace how data circulates between peers and how data modifications are performed during the circulation before reaching the destination for enhancing the reliability of exchanged information.However,such lineage tracing is not easy in current P2P networks,since data replications and modifications are performed independently by autonomous peers--this creates a lack of reliability among the records exchanged.In this paper,we propose a framework for traceable record exchange in a P2P network.By managing historical information in distributed peers,we make the modification and exchange histories of records traceable.One of the features of our work is that the database technologies are utilized for realizing the framework.Histories are maintained in a relational database in each peer,and tracing queries are written in the datalog query language and executed in a P2P network by cooperating peers.This paper describes the concept of the framework and overviews the approach to query processing.

  15. Refinement of the critical 2p25.3 deletion region

    DEFF Research Database (Denmark)

    De Rocker, Nina; Vergult, Sarah; Koolen, David;

    2015-01-01

    PURPOSE: Submicroscopic deletions of chromosome band 2p25.3 are associated with intellectual disability and/or central obesity. Although MYT1L is believed to be a critical gene responsible for intellectual disability, so far no unequivocal data have confirmed this hypothesis. METHODS: In this stu...

  16. Investigations on surface chemical analysis using X-ray photoelectron spectroscopy and optical properties of Dy3+-doped LiNa3P2O7 phosphor

    Science.gov (United States)

    Munirathnam, K.; Dillip, G. R.; Chaurasia, Shivanand; Joo, S. W.; Deva Prasad Raju, B.; John Sushma, N.

    2016-08-01

    Near white-light emitting LiNa3P2O7:Dy3+ phosphors were prepared by a conventional solid-state reaction method. The orthorhombic crystal structure of the phosphors was confirmed using X-ray diffraction (XRD), and the valence states of the surface elements were determined from the binding energies of Li 1s, O 1s, Na 1s, P 2p, and Dy 3d by X-ray photoelectron spectroscopy (XPS). Attenuated total reflectance (ATR) - Fourier transform infrared (FT-IR) spectroscopy was employed to identify the pyrophosphate groups in the phosphors. Diffuse reflectance spectra (DRS) show the absorption bands of the Dy3+ ions in the host material. Intense blue (481 nm) and yellow (575 nm) emissions were obtained at an excitation wavelength of 351 nm and are attributed to the 4F9/2 → 6H15/2 and 4F9/2 → 6H13/2 transitions of Dy3+ ions, respectively. The combination of these two intense bands generates light emission in the near-white region of the chromaticity diagram.

  17. Structural and physical properties in the system ZnO-B 2O 3-P 2O 5-R nO m

    Science.gov (United States)

    Li, Shengchun; Chen, Pei; Li, Yaogang

    2010-12-01

    The glass forming region in the quaternary system ZnO-B 2O 3-P 2O 5-R nO m has been determined. Glass transition temperature ( Tg), glass density ( ρ), thermal expansion coefficient ( α) and weight loss percentage ( WL) of these glasses were measured. The structure of (90- x- y)ZnO- xB 2O 3- yP 2O 5-10R nO m glass was characterized by infrared spectra (IR), Raman spectra and X-ray diffraction (XRD). Results of IR and Raman indicated that B 2O 3 participated in the glass network as a glass modifier and the IR band around 1440 cm -1 was ascribed to the v as(B-O-B) vibrations. Glass intensity increased with increase in B 2O 3 content. The disappearance of v s(P-O-P) vibration around 760 cm -1 indicated that P-O-B linkage was formed. XRD results revealed that the major crystalline phase changes with substitution of different amounts of B 2O 3: Zn 2P 2O 7 for 45ZnO- xB 2O 3-35P 2O 5-10R nO m glass, where x=0-20, and BPO 4 for 45ZnO- xB 2O 3-35P 2O 5-10R nO m glass, where x=30-40.

  18. A Novel Syndrome Affecting Multiple Mitochondrial Functions, Located by Microcell-Mediated Transfer to Chromosome 2p14-2p13

    Science.gov (United States)

    Seyda, Agnieszka; Newbold, Robert F.; Hudson, Thomas J.; Verner, Andrei; MacKay, Neviana; Winter, Susan; Feigenbaum, Annette; Malaney, Suzann; Gonzalez-Halphen, Diego; Cuthbert, Andrew P.; Robinson, Brian H.

    2001-01-01

    We have studied cultured skin fibroblasts from three siblings and one unrelated individual, all of whom had fatal mitochondrial disease manifesting soon after birth. After incubation with 1 mM glucose, these four cell strains exhibited lactate/pyruvate ratios that were six times greater than those of controls. On further analysis, enzymatic activities of the pyruvate dehydrogenase complex, the 2-oxoglutarate dehydrogenase complex, NADH cytochrome c reductase, succinate dehydrogenase, and succinate cytochrome c reductase were severely deficient. In two of the siblings the enzymatic activity of cytochrome oxidase was mildly decreased (by ∼50%). Metabolite analysis performed on urine samples taken from these patients revealed high levels of glycine, leucine, valine, and isoleucine, indicating abnormalities of both the glycine-cleavage system and branched-chain α-ketoacid dehydrogenase. In contrast, the activities of fibroblast pyruvate carboxylase, mitochondrial aconitase, and citrate synthase were normal. Immunoblot analysis of selected complex III subunits (core 1, cyt c1, and iron-sulfur protein) and of the pyruvate dehydrogenase complex subunits revealed no visible changes in the levels of all examined proteins, decreasing the possibility that an import and/or assembly factor is involved. To elucidate the underlying molecular defect, analysis of microcell-mediated chromosome-fusion was performed between the present study's fibroblasts (recipients) and a panel of A9 mouse:human hybrids (donors) developed by Cuthbert et al. (1995). Complementation was observed between the recipient cells from both families and the mouse:human hybrid clone carrying human chromosome 2. These results indicate that the underlying defect in our patients is under the control of a nuclear gene, the locus of which is on chromosome 2. A 5-cM interval has been identified as potentially containing the critical region for the unknown gene. This interval maps to region 2p14-2p13. PMID

  19. O2, pH, and redox potential microprofiles around Potamogeton malaianus measured using microsensors.

    Directory of Open Access Journals (Sweden)

    Bin Dong

    Full Text Available This study aimed to elucidate the effects of periphyton on the microprofiles of oxygen (O2, pH, and oxidation-reduction potential around the stems and leaves of a submerged macrophyte Potamogeton malaianus and on the plant growth in the eutrophic shallow Taihu Lake, China. The microprofiles were measured using a motorized microprofiling system equipped with microsensors. The leaf age of the macrophyte and periphyton exerted significant effects on the microprofiles of O2, pH, and oxidation-reduction potential. O2 concentration and pH increased whereas the oxidation-reduction potential decreased with decreasing distance to the stem/leaf surface. The fluctuation amplitudes of O2, pH, and oxidation-reduction potential were the largest in the microprofiles of mature leaves and the lowest in senescent leaves. The periphyton increased the thickness of the broad diffusive boundary layer and fluctuation amplitudes of O2, pH, and oxidation-reduction potential. When the periphyton was removed, the thickness of the broad diffusive boundary layer in the microprofiles of stems, senescent leaves, and mature leaves reduced by 29.0%, 49.72%, and 70.34%, and the O2, pH, and oxidation-reduction potential fluctuation amplitudes also declined accordingly. Our results suggest that a thick periphyton exerted negative effects on the growth of macrophytes by providing extensive shading and creating a barrier that hindered the transport of dissolved substances such as O2, and led to premature decline in macrophytes in the eutrophic Taihu Lake. The consequent implications can help to elucidate the control mechanism of the broad diffusive boundary layer around macrophytes on nutrient cycling in eutrophic waters and to better understand the role of this layer in the Taihu Lake and other similar eutrophic waters.

  20. Formulation development and evaluation of innovative two-polymer (SR-2P) bioadhesive vaginal gel.

    Science.gov (United States)

    Podaralla, Satheesh; Alt, Carsten; Shankar, Gita N

    2014-08-01

    The main objective of this investigation was to study the feasibility of developing a vaginal bioadhesive microbicide using a SRI's proprietary two-polymer gel platform (SR-2P). Several formulations were prepared with different combinations of temperature-sensitive polymer (Pluronic® F-127) and mucoadhesive polymer (Noveon® AA-1), producing gels of different characteristics. Prototype polymeric gels were evaluated for pH, osmolality, buffering capacity, and viscosity under simulated vaginal semen dilutions, and bioadhesivity using ex vivo mini pig vaginal tissues and texture analyzer. The pH of the polymeric gel formulations ranged from 5.1 to 6.4; the osmolality varied from 13 to 173 mOsm. Absolute viscosity ranged from 513 to 3,780 cPs, and was significantly reduced (1.5- to 3-fold) upon incubation with simulated vaginal and semen fluid mixture. Among the tested gels (indicated in the middle row as a molar ratio of a mixture of Noveon vs. Pluronic), only SR-2P retained gel structure upon dilution with simulated fluids and mild simulated coital stress. The pH of the SR-2P gel was maintained at about 4.6 in simulated vaginal fluid and also showed high peak force of adhesion in mini pig vaginal tissue. Furthermore, SR-2P gel caused no or only minimal irritation in a mouse vaginal irritation model. The results of this preliminary study demonstrated the potential application of SR-2P gel as a vaginal microbicide vehicle for delivery of anti-HIV agents. PMID:24781671

  1. The state dependence of the interaction of metastable rare gas atoms Rg sup * (ms sup 3 P sub 2 , sup 3 P sub 0 ) (Rg=Ne, Ar, Kr, Xe) with ground state sodium atoms

    Energy Technology Data Exchange (ETDEWEB)

    Schohl, S.; Mueller, M.W.; Meijer, H.A.J.; Ruf, M.W.; Hotop, H. (Kaiserslautern Univ. (Germany, F.R.). Fachbereich Physik); Morgner, H. (Witten-Herdecke Univ., Witten (Germany, F.R.). Inst. fuer Experimentalphysik)

    1990-08-01

    Using crossed beams of metastable rare gas atoms Rg{sup *}(ms {sup 3}P{sub 2}, {sup 3}P{sub 0}) (Rg=Ne, Ar, Kr, Xe) and ground state sodium atoms Na(3s {sup 2}S{sub 1/2}), we have measured the energy spectra of electrons released in the respective Penning ionization processes at thermal collision energies. For Rg{sup *}({sup 3}P{sub 2})+Na(3s), the spectra are quite similar for the different rare gases, both in width and shape; they reflect attractive interactions in the entrance channel with well depths D{sub e}{sup *} (meV) decreasing slowly from Rg=Ne to Xe as follows: 676(18); 602(23); 565(26); 555(30). For Rg{sup *}({sup 3}P{sub 0})+Na(3 s), the spectra vary strongly with the rare gas, indicating a change in the character of the interaction from van der Waals type attraction (Ne) to chemical binding for Kr and Xe with well depths D{sub e}{sup *} (meV) of: 51(19); 107(25); 432(30); 530(50). These findings are explained through model calculations of the respective potential curves, in which the exchange and the spin orbit interaction in the excited rare gas and the molecular interaction between the two valence s-electrons in terms of suitably chosen singlet and triplet potentials are taken into account. These calculations also explain qualitatively the experimental finding that the ratios q{sub 2}/q{sub 0} of the ionization cross sections for Rg{sup *}({sup 3}P{sub 2})+Na and Rg{sup *}({sup 3}P{sub 0})+Na vary strongly with the rare gas from Ne to Xe as follows: 15.8(3.2); 2.6(4); 1.4(2); 1.6(4). (orig.).

  2. Luteolin Inhibits Ischemia/Reperfusion-Induced Myocardial Injury in Rats via Downregulation of microRNA-208b-3p.

    Directory of Open Access Journals (Sweden)

    Chen Bian

    Full Text Available Luteolin (LUT, a kind of flavonoid which is extracted from a variety of diets, has been reported to convey protective effects of various diseases. Recent researches have suggested that LUT can carry out cardioprotective effects during ischemia/reperfusion (I/R. However, there have no reports on whether LUT can exert protective effects against myocardial I/R injury through the actions of specific microRNAs (miRs. The purpose of this study was to determine which miRs and target genes LUT exerted such function through.Expression of various miRs in perfused rat hearts was detected using a gene chip. Target genes were predicted with TargetScan, MiRDB and MiRanda. Anoxia/reoxygenation was used to simulate I/R. Cells were transfected by miR-208b-3p mimic, inhibitor and small interfering RNA of Ets1 (avian erythroblastosis virus E26 (v ets oncogene homolog 1. MiR-208b-3p and Ets1 mRNA were quantified by real-time quantitative polymerase chain reaction. The percentage of apoptotic cells was detected by annexin V-fluorescein isothiocyanate/propidium iodide dyeing and flow cytometry. The protein expression levels of cleaved caspase-3, Bcl-2, Bax, and Ets1 were examined by western blot analysis. A luciferase reporter assay was used to verify the combination between miR-208b-3p and the 3'-untranslated region of Ets1.LUT pretreatment reduced miR-208b-3p expression in myocardial tissue, as compared to the I/R group. And LUT decreased miR-208b-3p expression and apoptosis caused by I/R. However, overexpression of miR-208b-3p further aggravated the changes caused by I/R and blocked all the effects of LUT. Knockdown of miR-208b-3p expression also attenuated apoptosis, while knockdown of Ets1 promoted apoptosis. Further, the luciferase reporter assay showed that miR-208b-3p could inhibit Ets1 expression.LUT pretreatment conveys anti-apoptotic effects after myocardial I/R injury by decreasing miR-208b-3p and increasing Ets1 expression levels.

  3. Amplification at λ ∼ 2.8 A on Xe(L),(2s-bar2p-bar) double-vacancy states produced by 248 nm excitation of Xe clusters in plasma channels

    International Nuclear Information System (INIS)

    Xe(L),(2s-bar2p-bar) double-vacancy states undergo strong amplification in relativistic self-trapped plasma channels on 3d → 2p transitions in the λ = 2.78-2.81 A region. The 2P3/2 → 2S1/2 component at λ ≅ 2.786 A exhibits saturated amplification demonstrated by both (1) the observation of spectral hole-burning in the spontaneous emission profile and (2) the correlated enhancement of 3p → 2s cascade transitions (2S1/2 → 2Pj; j = 1/2, 3/2) at λ = 2.558 and λ = 2.600 A. The condition of saturation places a lower limit of ∼1017 W cm-2 on the intensity of the x-ray beam produced by the amplification in the channel. The anomalous strength of the amplification signalled by the saturation mirrors the equivalently anomalous behaviour observed for all 3d → 2p transitions corresponding to 2p-bar) single-vacancy Xeq+ arrays (q = 31, 32, 34, 35, 36) that exhibit gain. The conspicuous absence of amplification involving states with (2p-bar)2 double-vacancy configurations suggests the operation of a selective interaction that enhances the production of 2s-bar2p-bar states. Overall, the generation of double-vacancy states of this genre demonstrates that an excitation rate approaching ∼1 W/atom for ionic species is achievable in self-trapped plasma channels

  4. pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts

    DEFF Research Database (Denmark)

    Skarsfeldt, Mark A; Jepps, Thomas A; Bomholtz, Sofia H;

    2016-01-01

    In isolated human atrial cardiomyocytes, inhibition of K2P3.1 K(+) channels results in action potential (action potential duration (APD)) prolongation. It has therefore been postulated that K2P3.1 (KCNK3), together with K2P9.1 (KCNK9), could represent novel drug targets for the treatment of atria...

  5. miR-129-3p controls centrosome number in metastatic prostate cancer cells by repressing CP110.

    Science.gov (United States)

    Bijnsdorp, Irene V; Hodzic, Jasmina; Lagerweij, Tonny; Westerman, Bart; Krijgsman, Oscar; Broeke, Jurjen; Verweij, Frederik; Nilsson, R Jonas A; Rozendaal, Lawrence; van Beusechem, Victor W; van Moorselaar, Jeroen A; Wurdinger, Thomas; Geldof, Albert A

    2016-03-29

    The centrosome plays a key role in cancer invasion and metastasis. However, it is unclear how abnormal centrosome numbers are regulated when prostate cancer (PCa) cells become metastatic. CP110 was previously described for its contribution of centrosome amplification (CA) and early development of aggressive cell behaviour. However its regulation in metastatic cells remains unclear. Here we identified miR-129-3p as a novel metastatic microRNA. CP110 was identified as its target protein. In PCa cells that have metastatic capacity, CP110 expression was repressed by miR-129-3p. High miR-129-3p expression levels increased cell invasion, while increasing CP110 levels decreased cell invasion. Overexpression of CP110 in metastatic PCa cells resulted in a decrease in the number of metastasis. In tissues of PCa patients, low CP110 and high miR-129-3p expression levels correlated with metastasis, but not with the expression of genes related to EMT. Furthermore, overexpression of CP110 in metastatic PCa cells resulted in excessive-CA (E-CA), and a change in F-actin distribution which is in agreement with their reduced metastatic capacity. Our data demonstrate that miR-129-3p functions as a CA gatekeeper in metastatic PCa cells by maintaining pro-metastatic centrosome amplification (CA) and preventing anti-metastatic E-CA.

  6. Development of a chromosomally integrated metabolite-inducible Leu3p-alpha-IPM "off-on" gene switch.

    Directory of Open Access Journals (Sweden)

    Maria Poulou

    Full Text Available BACKGROUND: Present technology uses mostly chimeric proteins as regulators and hormones or antibiotics as signals to induce spatial and temporal gene expression. METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that a chromosomally integrated yeast 'Leu3p-alpha-IotaRhoMu' system constitutes a ligand-inducible regulatory "off-on" genetic switch with an extensively dynamic action area. We find that Leu3p acts as an active transcriptional repressor in the absence and as an activator in the presence of alpha-isopropylmalate (alpha-IotaRhoMu in primary fibroblasts isolated from double transgenic mouse embryos bearing ubiquitously expressing Leu3p and a Leu3p regulated GFP reporter. In the absence of the branched amino acid biosynthetic pathway in animals, metabolically stable alpha-IPM presents an EC(50 equal to 0.8837 mM and fast "OFF-ON" kinetics (t(50ON = 43 min, t(50OFF = 2.18 h, it enters the cells via passive diffusion, while it is non-toxic to mammalian cells and to fertilized mouse eggs cultured ex vivo. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that the 'Leu3p-alpha-IotaRhoMu' constitutes a simpler and safer system for inducible gene expression in biomedical applications.

  7. Regulatory role of the sequences downstream from nodD3 P1 promoter of Rhizobium meliloti

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The 660 bp region between nodD3 P1 promoter and the following coding region of Rhizobium meliloti has been studied.This region is designated "downstream sequences".It consists of two potential open reading frames,ORF1 and ORF2.Studies on the role of the downstream sequences on the activity of nodD3 P1 with nod D3(P1)-lacZ fusion show that deletion of the sequences containing ORF2 causes the increase of the activity of the fusion; on the contrary,addition of extra copies of ORF2 markedly decreases the activity of the fusion.These results indicate that the product of ORF2 plays a negative role in the expression of nod D3.

  8. Doubly excited {sup 3}P{sup e} resonance states of two-electron positive ions in Debye plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Xiao-Qing; Wang, Yang; Kar, Sabyasachi, E-mail: skar@hit.edu.cn, E-mail: karsabyasachi@yahoo.com [Center for Theoretical Atomic and Molecular Physics, Academy of Fundamental and Interdisciplinary Sciences, Harbin Institute of Technology, Harbin 150080 (China); Jiang, Zishi [College of Physical Science and Technology, Heilongjiang University, Harbin 150080 (China); Jiang, Pinghui [College of Electrical and Information Engineering, Heilongjiang Institute of Technology, Harbin 150050 (China)

    2015-11-15

    We investigate the doubly excited {sup 3}P{sup e} resonance states of two-electron positive ions Li{sup +}, Be{sup 2+}, B{sup 3+}, and C{sup 4+} by employing correlated exponential wave functions. In the framework of the stabilization method, we calculate two series (3pnp and 3dnd) of {sup 3}P{sup e} resonances below the N = 3 threshold. The {sup 3}P{sup e} resonance parameters (resonance energies and widths) are reported for the first time as a function of the screening parameter. For free-atomic cases, comparisons are made with the reported results and few resonance states are reported for the first time.

  9. Biomimetic-Inspired Infrared Sensors from Zn3P2 Microwires: Study of Their Photoconductivity and Infrared Spectrum Properties

    Directory of Open Access Journals (Sweden)

    M. Israelowitz

    2014-01-01

    Full Text Available The fire beetle, Melanophila acuminata (Coleoptera: Buprestidae, senses infrared radiation at wavelengths of 3 and 10–25 microns via specialized protein-containing sensilla. Although the protein denatures outside of a biological system, this detection mechanism has inspired our bottom-up approach to produce single zinc phosphide microwires via vapour transport for IR sensing. The Zn3P2 microwires were immobilized and electrical contact was made by dielectrophoresis. Photoconductivity measurements have been extended to the near IR range, spanning the Zn3P2 band gaps. Purity and integrity of the Zn3P2 microwires including infrared light scattering properties were confirmed by infrared transmission microscopy. This biomimetic microwire shows promise for infrared chip development.

  10. Na*(3p)-Formation under grazing scattering of Na[sup +]-ions at an Al(111) surface

    Energy Technology Data Exchange (ETDEWEB)

    Zimny, R. (Inst. fuer Kernphysik, Univ. Muenster (Germany)); Borisov, A.G. (Dept. of Physics, Moscow State Univ. (Russian Federation))

    1994-06-01

    Excited Na*(3p)-atoms are observed in grazing surface-collision experiments with Na[sup +]-beams. Such atoms can be formed beyond a certain threshold velocity via resonant electron transfer between atomic and metallic conduction band levels due to motion of the atom relative to the surface of the metal (''kinematic resonance''). This mechanism is studied here theoretically employing two different techniques: the nonperturbative ''Coupled Angular Mode'' (CAM) method and the approximate ''Transfer Hamiltonian'' (TH) method. The calculated Na*(3p)-populations agree well with recent experimental results. Moreover, the complete density matrix of the Na*(3p)-subspace has been computed with the TH-method for ion-energies between 10 and 300 keV. (orig.)

  11. Effect of carbon content on microstructure of in-situ Al2O3p-TiCp/Al composites

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The in-situ Al2O3p-TiCp/Al composite was fabricated by XD (exothermic dispersion) process in TiO2-Al-C system, and the effect of carbon content on the microstructure of the fabricated composite and the reactive temperature characteristics had been studied. The results show that carbon content affects the microstructure and reactive temperature of Al2O3p-TiCp/Al composite greatly. The quantity of TiC phases in the fabricated composites increases, while the Al3Ti phases reduces with increasing carbon content. And when C/TiO2 molecular ratio is equal to one, the Al3Ti phase nearly disappears. High temperature metallurgical field caused by strong exothermic reaction influences the synthetic reaction greatly, and higher synthetic temperature was favorable to the synthesis of Al2O3p-TiCp reinforce particles.

  12. Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database.

    Directory of Open Access Journals (Sweden)

    Raphaël Bourgeas

    Full Text Available BACKGROUND: In the last decade, the inhibition of protein-protein interactions (PPIs has emerged from both academic and private research as a new way to modulate the activity of proteins. Inhibitors of these original interactions are certainly the next generation of highly innovative drugs that will reach the market in the next decade. However, in silico design of such compounds still remains challenging. METHODOLOGY/PRINCIPAL FINDINGS: Here we describe this particular PPI chemical space through the presentation of 2P2I(DB, a hand-curated database dedicated to the structure of PPIs with known inhibitors. We have analyzed protein/protein and protein/inhibitor interfaces in terms of geometrical parameters, atom and residue properties, buried accessible surface area and other biophysical parameters. The interfaces found in 2P2I(DB were then compared to those of representative datasets of heterodimeric complexes. We propose a new classification of PPIs with known inhibitors into two classes depending on the number of segments present at the interface and corresponding to either a single secondary structure element or to a more globular interacting domain. 2P2I(DB complexes share global shape properties with standard transient heterodimer complexes, but their accessible surface areas are significantly smaller. No major conformational changes are seen between the different states of the proteins. The interfaces are more hydrophobic than general PPI's interfaces, with less charged residues and more non-polar atoms. Finally, fifty percent of the complexes in the 2P2I(DB dataset possess more hydrogen bonds than typical protein-protein complexes. Potential areas of study for the future are proposed, which include a new classification system consisting of specific families and the identification of PPI targets with high druggability potential based on key descriptors of the interaction. CONCLUSIONS: 2P2I database stores structural information about PPIs

  13. BOT3P: a mesh generation software package for transport analysis with deterministic and Monte Carlo codes

    International Nuclear Information System (INIS)

    BOT3P consists of a set of standard Fortran 77 language programs that gives the users of the deterministic transport codes DORT, TORT, TWODANT, THREEDANT, PARTISN and the sensitivity code SUSD3D some useful diagnostic tools to prepare and check the geometry of their input data files for both Cartesian and cylindrical geometries, including graphical display modules. Users can produce the geometrical and material distribution data for all the cited codes for both two-dimensional and three-dimensional applications and, only in 3-dimensional Cartesian geometry, for the Monte Carlo Transport Code MCNP, starting from the same BOT3P input. Moreover, BOT3P stores the fine mesh arrays and the material zone map in a binary file, the content of which can be easily interfaced to any deterministic and Monte Carlo transport code. This makes it possible to compare directly for the same geometry the effects stemming from the use of different data libraries and solution approaches on transport analysis results. BOT3P Version 5.0 lets users optionally and with the desired precision compute the area/volume error of material zones with respect to the theoretical values, if any, because of the stair-cased representation of the geometry, and automatically update material densities on the whole zone domains to conserve masses. A local (per mesh) density correction approach is also available. BOT3P is designed to run on Linux/UNIX platforms and is publicly available from the Organization for Economic Cooperation and Development (OECD/NEA)/Nuclear Energy Agency Data Bank. Through the use of BOT3P, radiation transport problems with complex 3-dimensional geometrical structures can be modelled easily, as a relatively small amount of engineer-time is required and refinement is achieved by changing few parameters. This tool is useful for solving very large challenging problems, as successfully demonstrated not only in some complex neutron shielding and criticality benchmarks but also in a power

  14. MiR-525-3p Enhances the Migration and Invasion of Liver Cancer Cells by Downregulating ZNF395

    OpenAIRE

    Fei Pang; Ruopeng Zha; Yingjun Zhao; Qifeng Wang; Di Chen; Zhenfeng Zhang; Taoyang Chen; Ming Yao; Jianren Gu; Xianghuo He

    2014-01-01

    Liver cancer is one of leading causes of cancer-related deaths. A deeper mechanistic understanding of liver cancer could lead to the development of more effective therapeutic strategies. In our previous work, we screened 646 miRNAs and identified 11 that regulate liver cancer cell migration. The current study shows that miR-525-3p is frequently up-regulated in liver cancer tissues, and enhanced expression of miR-525-3p can promote liver cancer cell migration and invasion. Zinc finger protein ...

  15. Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss

    OpenAIRE

    Gross, Andrew M.; Ryan K. Orosco; Shen, John P.; Egloff, Ann Marie; Carter, Hannah; Hofree, Matan; Choueiri, Michel; Charles S. Coffey; Lippman, Scott M.; Hayes, D. Neil; Cohen, Ezra E.; Grandis, Jennifer R.; Nguyen, Quyen T.; Ideker, Trey

    2014-01-01

    Head and neck squamous cell carcinoma (HNSCC) is characterized by aggressive behavior with a propensity for metastasis and recurrence. Here we report a comprehensive analysis of the molecular and clinical features of HNSCC that govern patient survival. We find that TP53 mutation is frequently accompanied by loss of chromosome 3p, and that the combination of both events associates with a surprising decrease in survival rates (1.9 years versus >5 years for TP53 mutation alone). The TP53-3p inte...

  16. Lifetime measurement of the metastable 2{sup 3}P{sub 0} state in He-like uranium

    Energy Technology Data Exchange (ETDEWEB)

    Toleikis, S. [Lawrence Berkeley National Laboratory, 1 Cyclotron Rd., MS 88R0192, Berkeley, CA 94720-8101 (United States) and Texas A and M University, College Station, TX (United States)]. E-mail: stoleikis@lbl.gov; Manil, B. [GANIL, Caen (France); Bednarz, G. [IFUJ, Cracow (Poland); Berdermann, E. [GSI, Darmstadt (Germany); Beyer, H.F. [GSI, Darmstadt (Germany); Bosch, F. [GSI, Darmstadt (Germany); Braeuning-Demian, A. [GSI, Darmstadt (Germany); Gumberidze, A. [GSI, Darmstadt (Germany); Indelicato, P. [Universite P. et M. Curie, Paris (France); Kozhuharov, C. [GSI, Darmstadt (Germany); Liesen, D. [GSI, Darmstadt (Germany); Marrus, R. [University of California, Berkeley, CA (United States); Mokler, P.H. [GSI, Darmstadt (Germany); Stachura, Z. [INP, Cracow (Poland); Stoehlker, T. [GSI, Darmstadt (Germany); Warczak, A. [IFUJ, Cracow (Poland)

    2005-07-01

    The lifetime of the 2{sup 3}P{sub 0} state in He-like uranium has been measured in a beam-foil time-of-flight experiment at the Gesellschaft fur Schwerionenforschung accelerator facility with the result {tau}(2{sup 3}P{sub 0})=58.2(9.5)ps. With the measured lifetime it is possible to derive a value of {delta}E{sub 2s}{sup Lamb}=76.3+/-20.6eV for the n=2 Lamb shift in uranium.

  17. Experimental transition probabilities of the intercombination line 1s2ws21S0-1s22s3p3P01 in Be-like ions of Na through Si

    International Nuclear Information System (INIS)

    The decay of the 1s22s3p3 Po0,1,2 levels in Be-like ions of Na, Mg, Al and Si has been investigated using the beam-foil method. The mean wavelengths of the transition 1s22p23P0,1,2-1s22s3p 3Po0,1,2 and the lifetimes of the 1s22s3p 3Po0,1,2 levels have been measured. An intercomparison of these lifetimes yields the transition probability of the intercombination line 1s22s21S0-1s22s3p 3Po1. The results are (3.45 ± 0.73) 109 s-1 in Na VIII, (5.55 ± 0.96) 109 s-1 in Mg IX, (1.21 ± 0.24) 1010 s-1 in Al X and (2.50 ± 0.54) 1010 s-1 in Si XI. (orig.)

  18. High lying energy positions of doubly (2pns) {sup 1,3}P{sup o} and (2pnd) {sup 1,3}P{sup o} excited states of the beryllium atom

    Energy Technology Data Exchange (ETDEWEB)

    Sakho, I., E-mail: aminafatima_sakho@yahoo.fr [UFR Sciences and Technologies, Department of physics, University of Ziguinchor, Ziguinchor (Senegal)

    2011-12-15

    The Screening Constant by Unit Nuclear Charge (SCUNC) method is used to study (2pns) {sup 1,3}P{sup o} and (2pnd) {sup 1,3}P{sup o} autoionizing states of the beryllium atom. Energy positions are reported up to n=20. In addition, resonance widths of the (2pns) {sup 1}P{sup o} states also presented. The current results compared very well to available theoretical and experimental literature values up to n=15. The accurate data presented in this work may be of interest for future experimental and theoretical studies in the photoabsorption spectrum of Be. - Highlights: > Accurate energy positions of (2pns) {sup 1,3}P{sup o} and (2pnd) {sup 1,3}P{sup o} (n=3-20) autoionizing states of Be atoms. > Currently results compared very well to theoretical and experimental literature values up to n=15. > Presently data may be of interest for future experimental and theoretical studies in the photoabsorption spectrum of Be.

  19. miR-199a-3p 靶基因预测及生物信息学分析%Prediction of miR-199a-3p targets gene and its bioinformatics analysis

    Institute of Scientific and Technical Information of China (English)

    谢小娟; 潘晶晶; 魏力强; 陈葳

    2016-01-01

    Objective To provide theoretical guidance for further research on the role of miR-1 99a-3p in formation and development of bladder cancer.Methods Mature sequence of miR-1 99a-3p was analyzed;target genes and transcription factors of miRNA-1 99a-3p were predicted,and the target genes were analyzed for gene ontology (GO)enrichment and Kyoto Encyclopedia of Genes and Genome (KEGG)pathway.Then TF-miRNA-mRNA network diagram was constructed.Results Sequences of miR-1 99a-3p were highly conserved in various species.In GO analysis,the target genes of miR-1 99a-3p were enriched in many biological processes,such as regulation of cellular process,regulation of macromolecule metabolic process,and regulation of biological process (P <0.01 ).In KEGG pathway,the target genes were mainly located in bacterial invasion pathway of epithelial cells,ECM-receptor interaction pathway,PI3K-Akt signaling pathway,MAPK signaling pathway,small cell lung cancer pathway,and proteoglycans pathway in the cancer (P <0.05).According to the TF-miRNA-mRNA network diagram,the important genes that might be regulated by miR-1 99a-3p were MYC,SP1,mTOR,NFκB,and NFκB1.Conclusion miR-1 99a-3p may directly target mTOR and participate in the formation and development of bladder cancer through regulating PI3K-Akt-mTOR signaling pathway.%目的:为深入研究 miR-199a-3p 在膀胱癌形成和发展中的作用提供理论依据。方法分析 miR-199a-3p 序列,预测其靶基因和转录因子,并对靶基因进行 GO 富集和 KEGG Pathway 分析;构建 TF-miR-199a-3p-靶基因网络调控图。结果miR-199a-3p 序列在多物种间具有高度保守性;GO 分析发现 miR-199a-3p 的靶基因参与细胞调节、代谢调节、细胞大分子生物合成等生物过程(P <0.01);KEGG Pathway 分析发现 miR-199a-3p 的靶基因显著富集在上皮细胞的细菌入侵通路、ECM 受体的相互作用通路、PI3K-Akt 信号通路、MAPK 信号通路、小细胞肺癌通路、癌症中的蛋白

  20. Novel preparation of highly dispersed Ni2P embedded in carbon framework and its improved catalytic performance

    Science.gov (United States)

    Wang, Shan; Wang, Kang; Wang, Xitao

    2016-11-01

    Highly dispersed Ni2P embedded in carbon framework with different phosphidation temperature was prepared through carbonizing Ni-alginate gel and followed by phosphidation with PPh3 in liquid phase. The significant effects of phosphidation temperature on Ni2P particle size and catalytic properties for isobutane dehydrogenation to isobutene were investigated. The results showed that Ni2P catalyst derived from the Ni-alginate gel (Ni2P-ADC), consisting of Ni2P particles embedded in carbon walls, possessed smaller particle size and more active site compared with Ni2P catalyst supported on active carbon (Ni2P/AC) prepared by impregnation method. The Ni2P-ADC catalyst phosphorized at 578 K for 3 h exhibited the highest catalytic performance, with the corresponding selectivity of isobutene approaching 89% and conversion approaching 15% after reaction for 4.5 h at 833 K, whereas Ni2P/AC catalyst prepared by impregnation method displays a much lower catalytic activity. The improved catalytic performance of the Ni2P-ADC can be ascribed to the smaller and highly dispersed Ni2P particles incorporated into carbon framework resulting from Ni-alginate gel.

  1. Efficiency and Nash Equilibria in a Scrip System for P2P Networks

    CERN Document Server

    Friedman, Eric j; Kash, Ian

    2007-01-01

    A model of providing service in a P2P network is analyzed. It is shown that by adding a scrip system, a mechanism that admits a reasonable Nash equilibrium that reduces free riding can be obtained. The effect of varying the total amount of money (scrip) in the system on efficiency (i.e., social welfare) is analyzed, and it is shown that by maintaining the appropriate ratio between the total amount of money and the number of agents, efficiency is maximized. The work has implications for many online systems, not only P2P networks but also a wide variety of online forums for which scrip systems are popular, but formal analyses have been lacking.

  2. Calculation of Computational Complexity for Radix-2 (p) Fast Fourier Transform Algorithms for Medical Signals.

    Science.gov (United States)

    Amirfattahi, Rassoul

    2013-10-01

    Owing to its simplicity radix-2 is a popular algorithm to implement fast fourier transform. Radix-2(p) algorithms have the same order of computational complexity as higher radices algorithms, but still retain the simplicity of radix-2. By defining a new concept, twiddle factor template, in this paper, we propose a method for exact calculation of multiplicative complexity for radix-2(p) algorithms. The methodology is described for radix-2, radix-2 (2) and radix-2 (3) algorithms. Results show that radix-2 (2) and radix-2 (3) have significantly less computational complexity compared with radix-2. Another interesting result is that while the number of complex multiplications in radix-2 (3) algorithm is slightly more than radix-2 (2), the number of real multiplications for radix-2 (3) is less than radix-2 (2). This is because of the twiddle factors in the form of which need less number of real multiplications and are more frequent in radix-2 (3) algorithm.

  3. n-p Short-Range Correlations from (p,2p+n) Measurements

    Science.gov (United States)

    Tang, A.; Watson, J. W.; Aclander, J.; Alster, J.; Asryan, G.; Averichev, Y.; Barton, D.; Baturin, V.; Bukhtoyarova, N.; Carroll, A.; Gushue, S.; Heppelmann, S.; Leksanov, A.; Makdisi, Y.; Malki, A.; Minina, E.; Navon, I.; Nicholson, H.; Ogawa, A.; Panebratsev, Yu.; Piasetzky, E.; Schetkovsky, A.; Shimanskiy, S.; Zhalov, D.

    2003-01-01

    We studied the 12C(p,2p+n) reaction at beam momenta of 5.9, 8.0, and 9.0 GeV/c. For quasielastic (p,2p) events pf, the momentum of the knocked-out proton before the reaction, was compared (event by event) with pn, the coincident neutron momentum. For |pn|>kF=0.220 GeV/c (the Fermi momentum) a strong back-to-back directional correlation between pf and pn was observed, indicative of short-range n-p correlations. From pn and pf we constructed the distributions of c.m. and relative motion in the longitudinal direction for correlated pairs. We also determined that 49±13% of events with |pf|>kF had directionally correlated neutrons with |pn|>kF.

  4. PISA: Federated Search in P2P Networks with Uncooperative Peers

    Science.gov (United States)

    Ren, Zujie; Shou, Lidan; Chen, Gang; Chen, Chun; Bei, Yijun

    Recently, federated search in P2P networks has received much attention. Most of the previous work assumed a cooperative environment where each peer can actively participate in information publishing and distributed document indexing. However, little work has addressed the problem of incorporating uncooperative peers, which do not publish their own corpus statistics, into a network. This paper presents a P2P-based federated search framework called PISA which incorporates uncooperative peers as well as the normal ones. In order to address the indexing needs for uncooperative peers, we propose a novel heuristic query-based sampling approach which can obtain high-quality resource descriptions from uncooperative peers at relatively low communication cost. We also propose an effective method called RISE to merge the results returned by uncooperative peers. Our experimental results indicate that PISA can provide quality search results, while utilizing the uncooperative peers at a low cost.

  5. IP2P K-means: an efficient method for data clustering on sensor networks

    Directory of Open Access Journals (Sweden)

    Peyman Mirhadi

    2013-03-01

    Full Text Available Many wireless sensor network applications require data gathering as the most important parts of their operations. There are increasing demands for innovative methods to improve energy efficiency and to prolong the network lifetime. Clustering is considered as an efficient topology control methods in wireless sensor networks, which can increase network scalability and lifetime. This paper presents a method, IP2P K-means – Improved P2P K-means, which uses efficient leveling in clustering approach, reduces false labeling and restricts the necessary communication among various sensors, which obviously saves more energy. The proposed method is examined in Network Simulator Ver.2 (NS2 and the preliminary results show that the algorithm works effectively and relatively more precisely.

  6. A Potential Approach of Internet Worm Propagation Based on P2P

    Institute of Scientific and Technical Information of China (English)

    YAO Yu; LUO Xingrui; GAO Fuxiang; YU Ge

    2006-01-01

    Various kinds of active worms have been plunging into the network flows, which make the Internet security problem more serious. Our research on a potential propagation approach of active worms, P2P-based propagation approach, is given in this paper. To measure the propagating performance of our approach, the SEI (Susceptible-Exposed- Infected) propagation model is presented. It proves that with the idea of pure P2P architecture, worms can be hidden in the early stage of propagation, and then infect most of the hosts in a shorter period. By comparing our SEI propagation model with the Simple Epidemic Model, we observe that the size of a worm is a significant parameter which can affect the propagating performance. When the size of the worm becomes large, our approach can still show an excellent propagating performance.

  7. Predicting the Impact of Measures Against P2P Networks on the Transient Behaviors

    CERN Document Server

    Altman, Eitan; Shwartz, Adam; Xu, Yuedong

    2010-01-01

    The paper has two objectives. The first is to study rigorously the transient behavior of some P2P networks where information is replicated and disseminated according to an epidemic type dynamics. The second is to use the insight gained in order to predict how efficient are measures taken against peer to peer networks. We first study a model which extends a classical epidemic model to characterize the peer to peer swarms in the presence of free riding peers. We then study a second model that a peer initiates a contact with another peer chosen randomly. In both cases, the network is shown to have a phase transition: a small change in the parameters causes a large change in the behavior of the network. We show in particular how the phase transition affects measures that content provider networks may take against P2P networks that distribute non-authorized music or books, and what is the efficiency of counter-measures.

  8. Using of P2P Networks for Acceleration of RTE Tasks Solving

    Directory of Open Access Journals (Sweden)

    Adrian Iftene

    2008-07-01

    Full Text Available In the last years the computational Grids have become an important research area in large-scale scientific and engineering research. Our approach is based on Peer-to-peer (P2P networks, which are recognized as one of most used architectures in order to achieve scalability in key components of Grid systems. The main scope in using of a computational Grid was to improve the computational speed of systems that solve complex problems from Natural Language processing field. We will see how can be implemented a computational Grid using the P2P model, and how can be used SMB protocol for file transfer. After that we will see how we can use this computational Grid, in order to improve the computational speed of a system used in RTE competition [1], a new complex challenge from Natural Language processing field.

  9. n-p short-range correlations from (p,2p+n) measurements.

    Science.gov (United States)

    Tang, A; Watson, J W; Aclander, J; Alster, J; Asryan, G; Averichev, Y; Barton, D; Baturin, V; Bukhtoyarova, N; Carroll, A; Gushue, S; Heppelmann, S; Leksanov, A; Makdisi, Y; Malki, A; Minina, E; Navon, I; Nicholson, H; Ogawa, A; Panebratsev, Yu; Piasetzky, E; Schetkovsky, A; Shimanskiy, S; Zhalov, D

    2003-01-31

    We studied the 12C(p,2p+n) reaction at beam momenta of 5.9, 8.0, and 9.0 GeV/c. For quasielastic (p,2p) events p(f), the momentum of the knocked-out proton before the reaction, was compared (event by event) with p(n), the coincident neutron momentum. For |p(n)|>k(F)=0.220 GeV/c (the Fermi momentum) a strong back-to-back directional correlation between p(f) and p(n) was observed, indicative of short-range n-p correlations. From p(n) and p(f) we constructed the distributions of c.m. and relative motion in the longitudinal direction for correlated pairs. We also determined that 49+/-13% of events with |p(f)|>k(F) had directionally correlated neutrons with |p(n)|>k(F). PMID:12570411

  10. n-p Short-Range Correlations from (p,2p + n) Measurements

    OpenAIRE

    Tang, A.; Watson, J. W.; Aclander, J.; Alster, J.; Asryan, G.; Averichev, Y.; Barton, D; Baturin, V.; Bukhtoyarova, N.; Carroll, A.; Heppelmann, S.; Leksanov, A.; Makdisi, Y.; Malki, A.; Minina, E.

    2002-01-01

    We studied the $^{12}$C(p,2p+n) reaction at beam momenta of 5.9, 8.0 and 9.0 GeV/c. For quasielastic (p,2p) events we reconstructed {\\bf p_f} the momentum of the knocked-out proton before the reaction; {\\bf p_f} was then compared (event-by-event) with {\\bf p_n}, the measured, coincident neutron momentum. For $|p_n|$ > k$_F$ = 0.220 GeV/c (the Fermi momentum) a strong back-to-back directional correlation between {\\bf p_f} and {\\bf p_n} was observed, indicative of short-range n-p correlations. ...

  11. High Quality of Service on Video Streaming in P2P Networks using FST-MDC

    CERN Document Server

    Jaganathan, Suresh; 10.5121/ijma.2011.3203

    2011-01-01

    Video streaming applications have newly attracted a large number of participants in a distribution network. Traditional client-server based video streaming solutions sustain precious bandwidth provision rate on the server. Recently, several P2P streaming systems have been organized to provide on-demand and live video streaming services on the wireless network at reduced server cost. Peer-to-Peer (P2P) computing is a new pattern to construct disseminated network applications. Typical error control techniques are not very well matched and on the other hand error prone channels has increased greatly for video transmission e.g., over wireless networks and IP. These two facts united together provided the essential motivation for the development of a new set of techniques (error concealment) capable of dealing with transmission errors in video systems. In this paper, we propose an flexible multiple description coding method named as Flexible Spatial-Temporal (FST) which improves error resilience in the sense of fra...

  12. Optoelectronic devices based on MoTe2 p-n junction

    Science.gov (United States)

    Bie, Ya-Qing; Heuck, Mikkel; Furchi, Marco; Grosso, Gabriele; Zheng, Jiabao; Cao, Yuan; Navarro-Moratalla, Efren; Englund, Dirk; Jarillo-Herrero, Pablo

    2D transition metal dichalcogenides (2D-TMD), such as MoS2, have been verified with many remarkable physical properties, which include an indirect to direct band transition as a function of thickness and a valley dependent spin polarization. One of the 2D-TMD family members, 2H-MoTe2 has been shown to be a direct bandgap semiconductor as a monolayer and bilayer with a near infrared (NIR) bandgap of about 1.1eV. However, optoelectronic devices based on MoTe2 were so far not experimentally demonstrated. Here, we will present a high on-off ratio MoTe2 p-n junction enabled by a hexagonal boron nitride encapsulation technique. Our study of the MoTe2 p-n junction devices sheds light on designing efficient NIR optoelectronic devices such as photodetectors and energy harvesting cells and light emitters.

  13. Derivatives of benzimidazole: vasodilator activity of 2-(p-chloro-alpha-hydroxybenzyl)-benzimidazole hydrochloride. Preliminary study.

    Science.gov (United States)

    Demenge, P; Carraz, G; Luu Duc, C; Silice, C

    1979-01-01

    The effects of 2-(p-chloro-alpha-hydroxybenzyl)-benzimidazole hydrochloride (HBBPC) have been studied in the rabbit and rat. Most of these studies were performed comparatively with reference vasodilators and papaverine. HBBPC vasodilator activity is nearly the same as that of papaverine in the isolated rabbit ear. The characteristic of the vasoactive action of HBBPC seems to reside in its duration. The mechanism of action of HBBPC seems of peripheral type, that is to say it acts on the vascular smooth muscle.

  14. Towards a P2P-Based Deployment of Network Management Information

    OpenAIRE

    Makhloufi, Rafik; Bonnet, Grégory; Doyen, Guillaume; Gaïti, Dominique

    2010-01-01

    International audience Standard static centralized network management approaches are unsuitable for managing large, dynamic and distributed networks. Some decentralized approaches based on the P2P model have emerged to overcome the limitations of these centralized approaches like lack of scalability and fault-tolerance. However, they do not address issues related to the deployment of management information which is crucial in a decentralized management context because of the heterogeneous ...

  15. Cross sections for H(2p) formation in slow He{sup 2+}-H collisions

    Energy Technology Data Exchange (ETDEWEB)

    Higgins, D.P.; Geddes, J.; McCullough, R.W. [The Queen`s Univ. of Belfast (United Kingdom)] [and others

    1994-12-31

    A crossed beam method, previously developed in this laboratory, has been used to study H(2p) formation in He{sup 2+}-H collision by observing the spontaneous emission of Lyman alpha radiation. Measurements at energies below 8 keV amu{sup {minus}1} usefully extend previous higher energy data into an energy range where theoretical predictions are markedly different and exhibit interesting structures which reflect the complexity of the excitation mechanism.

  16. csi2p modulates microtubule dynamics and organizes the bipolar spindle for chromosome segregation

    OpenAIRE

    Costa, Judite; Fu, Chuanhai; Khare, V. Mohini; Tran, Phong T.

    2014-01-01

    Proper chromosome segregation is of paramount importance for proper genetic inheritance. Defects in chromosome segregation can lead to aneuploidy, which is a hallmark of cancer cells. Eukaryotic chromosome segregation is accomplished by the bipolar spindle. Additional mechanisms, such as the spindle assembly checkpoint and centromere positioning, further help to ensure complete segregation fidelity. Here we present the fission yeast csi2 +. csi2p localizes to the spindle poles, where it regul...

  17. Protocols for Bio-Inspired Resource Discovery and Erasure Coded Replication in P2P Networks

    CERN Document Server

    Thampi, Sabu M

    2010-01-01

    Efficient resource discovery and availability improvement are very important issues in unstructured P2P networks. In this paper, a bio-inspired resource discovery scheme inspired by the principle of elephants migration is proposed. A replication scheme based on Q-learning and erasure codes is also introduced. Simulation results show that the proposed schemes significantly increases query success rate and availability, and reduces the network traffic as the resources are effectively distributed to well-performing nodes.

  18. A population dynamics model for data streaming over P2P networks

    OpenAIRE

    Xu, J.; Yang, G.; Li, VOK

    2009-01-01

    Data streaming (DS) over Peer-to-Peer (P2P) networks has been intensively studied in recent years and there have been various schemes proposed already. To evaluate these schemes, either measurement in experimental implementations, or simulation and theoretical analysis have been used. The former is inadequate as data are collected from different experiments, while the latter lacks a proper theoretical dynamics model. Our research aims at providing a general theoretical model to evaluate DS ov...

  19. Personalized Trust Management for Open and Flat P2P Communities

    Institute of Scientific and Technical Information of China (English)

    ZUO Min; LI Jian-hua

    2008-01-01

    A personalized trust management scheme is proposed to help peers build up trust between each other in open and flat P2P communities. This scheme totally abandons the attempt to achieve a global view. It evaluates trust from a subjective point of view and gives personalized decision support to each peer. Simulation experiments prove its three advantages: free of central control, stronger immunity to misleading recommendations, and limited traffic overload.

  20. Hybrid information retrieval policies based on cooperative cache in mobile P2P networks

    Institute of Scientific and Technical Information of China (English)

    Quanqing XU; Hengtao SHEN; Zaiben CHEN; Bin CUI; Xiaofang ZHOU; Yafei DAI

    2009-01-01

    The concept of Peer-to-Peer (P2P) has been in-troduced into mobile networks, which has led to the emer-gence of mobile P2P networks, and originated potential ap-plications in many fields. However, mobile P2P networks are subject to the limitations of transmission range, and highly dynamic and unpredictable network topology, giving rise to many new challenges for efficient information retrieval. In this paper, we propose an automatic and economical hybrid information retrieval approach based on cooperative cache. In this method, the region covered by a mobile P2P network is partitioned into subregions, each of which is identified by a unique ID and known to all peers. All the subregions then constitute a mobile Kademlia (MKad) network. The pro-posed hybrid retrieval approach aims to utilize the flooding-based and Distributed Hash Table (DHT)-based schemes in MKad for indexing and searching according to the designed utility functions. To further facilitate information retrieval, we present an effective cache update method by considering all relevant factors. At the same time, the combination of two different methods for cache update is also introduced. One of them is pull based on time stamp including two different pulls: an on-demand pull and a periodical pull, and the other is a push strategy using update records. Furthermore, we provide detailed mathematical analysis on the cache hit ratio of our approach. Simulation experiments in NS-2 showed that the proposed approach is more accurate and efficient than the existing methods.

  1. Formulation Development and Evaluation of Innovative Two-Polymer (SR-2P) Bioadhesive Vaginal Gel

    OpenAIRE

    Podaralla, Satheesh; Alt, Carsten; Shankar, Gita N.

    2014-01-01

    The main objective of this investigation was to study the feasibility of developing a vaginal bioadhesive microbicide using a SRI’s proprietary two-polymer gel platform (SR-2P). Several formulations were prepared with different combinations of temperature-sensitive polymer (Pluronic® F-127) and mucoadhesive polymer (Noveon® AA-1), producing gels of different characteristics. Prototype polymeric gels were evaluated for pH, osmolality, buffering capacity, and viscosity under simulated vaginal s...

  2. RIAPPA: a robust identity assignment protocol for P2P overlays

    OpenAIRE

    Caubet Fernández, Juan; Esparza Martín, Óscar; Muñoz Tapia, José Luis; Alins Delgado, Juan José; Mata Diaz, Jorge

    2014-01-01

    Peer-to-peer (P2P) overlay networks have been proposed to solve routing problems of big distributed infrastructures, even for Internet scale. But the research community has been questioning the security of these networks for years. Most prior work in security services was focused on trust and reputation systems, anonymity, and secure routing. However, the proper management of identities in overlays is an important prerequisite to provide most of these security services. In this paper, we prop...

  3. Parameterized Adaptive Multidimensional Integration Routines (PAMIR): Localization by Repeated 2^p Subdivision

    OpenAIRE

    Adler, Stephen L.

    2010-01-01

    This book draft gives the theory of a new method for p dimensional adaptive integration by repeated 2^p subdivision of simplexes and hypercubes. A new method of constructing high order integration routines for these geometries permits adjustable samplings of the integration region controlled by user supplied parameters. An outline of the programs and use instructions are also included in the draft. The fortran programs are not included, but will be published with this draft as a book.

  4. Inner-Shell Excitations of 2p Electrons of Argon Investigated by Fast Electron Impact with High Resolution

    Institute of Scientific and Technical Information of China (English)

    REN Lin-Mao; WANG You-Yan; LI Dong-Dong; YUAN Zhen-Sheng; ZHU Lin-Fan

    2011-01-01

    @@ Electron energy loss spectra of inner-shell excitations of 2p electrons of argon are measured at an incident electron energy of 2500eV and scattering angles of 0° and 4°.The dipole-forbidden transitions of 2p3/2-14p and 2p3/2-15p are observed in the measured spectra and assigned based on the calculations of the Cowan code.The positions and line widths for the excitations of 2p3/2-1nl and 2p1/2-1nl(n ≤ 5) of argon are determined.The present results show that the line widths of the electric quadrupole transitions of 2p3/2-14p[5/2 + 3/2]2 and the electric monopole one of 2p3/2-14p[1/2]0 are less than those of the dipole-allowed transitions.%Electron energy loss spectra of inner-shell excitations of 2p electrons of argon are measured at an incident electron energy of 2500eV and scattering angles of 0° and 4°. The dipole-forbidden transitions of 2p-13/24p and 2p-13/25p are observed in the measured spectra and assigned based on the calculations of the Cowan code. The positions and line widths for the excitations of 2p-13/2nl and 2p-11/2nl(n ≤ 5) of argon are determined. The present results show that the line widths of the electric quadrupole transitions of 2p-13/24p[5/2 + 3/2]2 and the electric monopole one of 2p-13/2 4p[1/2]o are less than those of the dipole-allowed transitions.

  5. A Prediction System Using a P2P Overlay Network for a Bus Arrival System

    Directory of Open Access Journals (Sweden)

    Ssu-Hsuan Lu

    2014-01-01

    Full Text Available Along with the evolution of times and the surge of metropolitan populations, government agencies often promote the construction of public transport. Unlike rail transportation or rapid transit systems, it is often difficult to estimate the vehicle arrival times at each station in a bus transportation system due to metropolitan transportation congestion. Traffic status is often monitored using wireless sensor networks (WSNs. However, WSNs are always separated from one another spatially. Recent studies have considered the connection of multiple sensor networks. This study considers a combination view of peer-to-peer (P2P overlay networks and WSN architecture to predict bus arrival times. Each bus station, which is also a P2P overlay peer, is connected in a P2P overlay network. A sensor installed in each bus can receive data via peers to obtain the moving speed of a bus. Then, each peer can exchange its data to predict bus arrival times at bus stations. This method can considerably increase the accuracy with which bus arrival times can be predicted and can provide traffic status with high precision. Furthermore, these data can also be used to plan new bus routes according to the information gathered.

  6. SKIP:an efficient search mechanism in unstructured P2P networks

    Institute of Scientific and Technical Information of China (English)

    SHEN Wen-wu; SU Sen; SHUANG Kai; YANG Fang-chun

    2010-01-01

    Search efficiency and accuracy of resource are important considerations for search algorithm in peer-to-peer(P2P)network.Most search algorithms use flooding among neighbor nodes to search relevant resource.However,this usually causes great amount of redundant messages,which results in high search costs and low search precision.In this paper,we use vector space model(VSM)and relevance ranking algorithms to construct overlay network,and a novel search mechanism search with K-iteration preference(SKIP)based on semantic group for P2P networks is proposed to efficiently solve these problems.The key idea of SKIP is to reorder the semantic neighbors of nodes according to relevant scores and to utilize preference selection during the process of query.We analysis and implement the scheme and reveal that the SKIP provides a low overhead on topology maintenance,which can be effectively used in P2P searching and verify it outperformanee in higher precision and lower search cost by comparing with current semantic-based searching mechanism gnutella-like efficient searching system(GES).

  7. Agreement Maintenance Based on Schema and Ontology Change in P2P Environment

    CERN Document Server

    Banowosari, L Y; Mutiara, A B

    2010-01-01

    This paper is concern about developing a semantic agreement maintenance method based on semantic distance by calculating the change of local schema or ontology. This approach is important in dynamic and autonomous environment, in which the current approach assumed that agreement or mapping in static environment. The contribution of this research is to develop a framework based on semantic agreement maintenance approach for P2P environment. This framework based on two level hybrid P2P model architecture, which consist of two peer type: (1) super peer that use to register and manage the other peers, and (2) simple peer, as a simple peer, it exports and shares its contents with others. This research develop a model to maintain the semantic agreement in P2P environment, so the current approach which does not have the mechanism to know the change, since it assumed that ontology and local schema are in the static condition, and it is different in dynamic condition. The main issues are how to calculate the change of...

  8. KEAMANAN STEVIA HASIL BUDIDAYA B2P2TO2T DALAM ASPEK TERATOGENITAS

    Directory of Open Access Journals (Sweden)

    Lucie Widowati

    2012-07-01

    Full Text Available Teratogenic test has been performed on sweet stevia as product of B2P2TO2T cultivation at  rats (Rattus novergicus pregnant female  Wistar. Stevia sweet was administered orally at a dose of 360, 120 and 40 mg/kg bw, volume 1 ml/100g bw per day during organogenesis period, on the day of pregnancy to the 6th until 15th. During the test, test animals were observed two times daily with the distance of six hours against the toxicity symptoms such as changes in skin, hair, eyes and mucous membranes, bleeding. Animals that experienced abortion, premature birth or death during the trial period were sacrificed and observed immediately with microscopic technic. At 20th day of pregnancy all of the pregnant rat dissected, and put out the fetuses  from the mother's and observated the health conditions in general and  the whole of mothers reproductive systems of fetuses, the outer fetal malformation and soft tissue system of fetal. The conclusion were  sweet stevia  of B2P2TO2T  no worse effect on the mother rats, fetal body weight and morphology of mother rats and the fetus, does not affect the process of development of fetal soft tissue, and does not affect the development of fetal skeleton. Generally the B2P2TO2T stevia sweet substances safe for used, does not cause teratogenic effects.

  9. Optimally Efficient Prefix Search and Multicast in Structured P2P Networks

    CERN Document Server

    Bradler, Dirk; Muehlhaeuser, Max

    2008-01-01

    Searching in P2P networks is fundamental to all overlay networks. P2P networks based on Distributed Hash Tables (DHT) are optimized for single key lookups, whereas unstructured networks offer more complex queries at the cost of increased traffic and uncertain success rates. Our Distributed Tree Construction (DTC) approach enables structured P2P networks to perform prefix search, range queries, and multicast in an optimal way. It achieves this by creating a spanning tree over the peers in the search area, using only information available locally on each peer. Because DTC creates a spanning tree, it can query all the peers in the search area with a minimal number of messages. Furthermore, we show that the tree depth has the same upper bound as a regular DHT lookup which in turn guarantees fast and responsive runtime behavior. By placing objects with a region quadtree, we can perform a prefix search or a range query in a freely selectable area of the DHT. Our DTC algorithm is DHT-agnostic and works with most exi...

  10. K2P$^2$: Reduced data from campaigns 0-4 of the K2 mission

    CERN Document Server

    Handberg, R

    2016-01-01

    Context: After the loss of a second reaction wheel the Kepler mission was redesigned as the K2 mission, pointing towards the ecliptic and delivering data for new fields approximately every 80 days. The steady flow of data obtained with a reduced pointing stability calls for dedicated pipelines for extracting light curves and correcting these for use in, e.g., asteroseismic analysis. Aims: We provide corrected light curves for the K2 fields observed until now (campaigns 0-4), and provide a comparison with other pipelines for K2 data extraction/correction. Methods: Raw light curves are extracted from K2 pixel data using the "K2-pixel-photometry" (K2P$^2$) pipeline, and corrected using the KASOC filter. Results: The use of K2P$^2$ allows for the extraction of the order of 90.000 targets in addition to 70.000 targets proposed by the community - for these, other pipelines provide no data. We find that K2P$^2$ in general performs as well as, or better than, other pipelines for the tested metrics of photometric qual...

  11. Modified Grapheme Encoding and Phonemic Rule to Improve PNNR-Based Indonesian G2P

    Directory of Open Access Journals (Sweden)

    Suyanto

    2016-03-01

    Full Text Available A grapheme-to-phoneme conversion (G2P is very important in both speech recognition and synthesis. The existing Indonesian G2P based on pseudo nearest neighbour rule (PNNR has two drawbacks: the grapheme encoding does not adapt all Indonesian phonemic rules and the PNNR should select a best phoneme from all possible conversions even though they can be filtered by some phonemic rules. In this paper, a modified partial orthogonal binary grapheme encoding and a phonemic-based rule are proposed to improve the performance of PNNR-based Indonesian G2P. Evaluating on 5-fold cross-validation, contain 40K words to develop the model and 10K words to evaluation each, shows that both proposed concepts reduce the relative phoneme error rate (PER by 13.07%. A more detail analysis shows the most errors are from grapheme ?e? that can be dynamically converted into either /E/ or /??/ since four prefixes, ’ber’, ’me’, ’per’, and ’ter’, produce many ambiguous conversions with basic words and also from some similar compound words with both different pronunciations for the grapheme ?e?. A stemming procedure can be applied to reduce those errors.

  12. 8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction.

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    Mariell Pettersson

    Full Text Available Small molecule nonpeptidic mimics of α-helices are widely recognised as protein-protein interaction (PPIs inhibitors. Protein-protein interactions mediate virtually all important regulatory pathways in a cell, and the ability to control and modulate PPIs is therefore of great significance to basic biology, where controlled disruption of protein networks is key to understanding network connectivity and function. We have designed and synthesised two series of 2,6,9-substituted 8-triazolylpurines as α-helix mimetics. The first series was designed based on low energy conformations but did not display any biological activity in a biochemical fluorescence polarisation assay targeting MDM2/p53. Although solution NMR conformation studies demonstrated that such molecules could mimic the topography of an α-helix, docking studies indicated that the same compounds were not optimal as inhibitors for the MDM2/p53 interaction. A new series of 8-triazolylpurines was designed based on a combination of docking studies and analysis of recently published inhibitors. The best compound displayed low micromolar inhibitory activity towards MDM2/p53 in a biochemical fluorescence polarisation assay. In order to evaluate the applicability of these compounds as biologically active and intrinsically fluorescent probes, their absorption/emission properties were measured. The compounds display fluorescent properties with quantum yields up to 50%.

  13. Fault Tolerant PLBGSA: Precedence Level Based Genetic Scheduling Algorithm for P2P Grid

    Directory of Open Access Journals (Sweden)

    Piyush Chauhan

    2013-01-01

    Full Text Available Due to monetary limitation, small organizations cannot afford high end supercomputers to solve highly complex tasks. P2P (peer to peer grid computing is being used nowadays to break complex task into subtasks in order to solve them on different grid resources. Workflows are used to represent these complex tasks. Finishing such complex task in a P2P grid requires scheduling subtasks of workflow in an optimized manner. Several factors play their part in scheduling decisions. The genetic algorithm is very useful in scheduling DAG (directed acyclic graph based task. Benefit of a genetic algorithm is that it takes into consideration multiple criteria while scheduling. In this paper, we have proposed a precedence level based genetic algorithm (PLBGSA, which yields schedules for workflows in a decentralized fashion. PLBGSA is compared with existing genetic algorithm based scheduling techniques. Fault tolerance is a desirable trait of a P2P grid scheduling algorithm due to the untrustworthy nature of grid resources. PLBGSA handles faults efficiently.

  14. Relativistic calculations of 3s2 1S0-3s3p 1P1 and 3s2 1S0-3s3p 3P1,2 transition probabilities in the Mg isoelectronic sequence

    Institute of Scientific and Technical Information of China (English)

    Cheng Cheng; Gao Xiang; Qing Bo; Zhang Xiao-Le; Li Jia-Ming

    2011-01-01

    Using the multi-configuration Dirac-Fock self-consistent field method and the relativistic configuration-interaction method, calculations of transition energies, oscillator strengths and rates are performed for the 3s2 1S0-3s3p 1P1 spinallowed transition, 3s2 1S0-3s3p 3P1,2 intercombination and magnetic quadrupole transition in the Mg isoelectronic sequence (Mg Ⅰ, Al Ⅱ, Si ⅢⅢ, P Ⅳ and S Ⅴ). Electron correlations are treated adequately, including intravalence electron correlations. The influence of the Breit interaction on oscillator strengths and transition energies are investigated. Quantum electrodynamics corrections are added as corrections. The calculation results are found to be in good agreement with the experimental data and other theoretical calculations.

  15. Radiative rates for E1, E2, M1, and M2 transitions among the 3s$^2$3p$^5$, 3s3p$^6$, and 3s$^2$3p$^4$3d configurations of Cl-like W LVIII

    CERN Document Server

    Aggarwal, K M

    2014-01-01

    We report calculations of energy levels, radiative decay rates, and lifetimes for transitions among the 3s$^2$3p$^5$, 3s3p$^6$, and 3s$^2$3p$^4$3d configurations of Cl-like W LVIII. The general-purpose relativistic atomic structure package (GRASP) has been adopted for our calculations. Comparisons are made with the most recent results of Mohan et al. [Can. J. Phys. {\\bf 92} (2014) xxx] and discrepancies in lifetimes are noted, up to four orders of magnitude in some instances. Our energy levels are estimated to be accurate to better than 0.5\\%, whereas results for radiative rates and lifetimes should be accurate to better than 20\\%.

  16. Effect of heat-treatment on properties of water-atomized amorphous Fe_(74)Cr_2Mo_2Sn_2P_(10)C_2Si_4B_4 magnetic powder cores%热处理对水雾化Fe_(74)Cr_2Mo_2Sn_2P_(10)C_2Si_4B_4非晶磁粉芯性能的影响

    Institute of Scientific and Technical Information of China (English)

    李庆达; 张伟; 胡军; 刘天祥; 王黎明; 连法增; 陆曹卫

    2012-01-01

    Water-atomized amorphous Fe74Cr2Mo2Sn2P10C2Si4B4 magnetic powder cores with better high-frequency magnetic properties were prepared.The effect of annealing and magnetic annealing on its magnetic properties was researched.The results show that magnetic permeability and quality factor of the Fe74Cr2Mo2Sn2P10C2Si4B4 magnetic powder core increase effectively after annealing.Over-annealing can deteriorate magnetic properties for crystallization of amorphous powder and forming of nonmagnetic phase.The optimum annealing temperature is 400 ℃,the optimum magnetic permeability is 40.5 and the optimum quality factor is 225 in frequency of 3500 kHz.Magnetic annealing has less effect on permeability of the amorphous magnetic powder core.Longitudinal magnetic annealing can increase total loss of the amorphous magnetic powder core,transverse magnetic annealing can decrease total loss.The change of total loss depends on hysteresis loss.%采用水雾化Fe74Cr2Mo2Sn2P10C2Si4B4非晶磁粉制备出了高频特性较好的磁粉芯。研究了去应力退火和磁场退火对磁粉芯磁性能的影响。结果表明:非晶磁粉芯压制后的去应力退火处理能有效提高磁导率和品质因数。过高热处理温度使非晶粉末晶化,析出导电性较差的非铁磁相,恶化磁性能。最佳退火温度为400℃,最佳的磁性能为:在3500 kHz的频率下,μ=40.5,Q=225。磁场退火对Fe74Cr2Mo2Sn2P10C2Si4B4非晶磁粉芯磁导率影响较小。纵向磁场退火能增大非晶磁粉芯的损耗,横向磁场退火能降低非晶磁粉芯的损耗,磁粉芯总损耗变化主要来源于磁滞损耗。

  17. LEAN MANUFACTURING: CONTINUOUS IMPROVEMENT OF PRODUCTIVITY USING KAIZEN 3P PHILOSOPHY IN A LARGE SIZED COMPANY IN BOTUCATU, SP, BRAZIL

    Directory of Open Access Journals (Sweden)

    Fernando Doriguel

    2015-06-01

    Full Text Available The search for excellence in a company´s production occurs mainly from developing reputable philosophies by training and monitoring groups which are formed by the company itself. Due to such factors as well as the necessity to increase excellence in production, new methodologies as Kaizen 3P (Production Preparation Process is still little known. This paper aims at deploying Lean Manufacturing which used Kaizen 3P method in a production line in order to reduce the operator time in production as wellas to reduce the product cycling time in assembling line. Results showed that Kaizen 3P method used in the company reduced man hour (MH in all the process reduction 660 hours. Furthermore assembling line had a time reduction 200 hours. Product route had a reduction of 17,6 kilometers. It was possible to conclude that the correct use of Kaizen 3P tool based on Lean manufacturing showed significant and productive gains when compared to old working methods adopted by the company.

  18. Absence of mutations in the coding sequence of the potential tumor suppressor 3pK in metastatic melanoma

    Directory of Open Access Journals (Sweden)

    Houben Roland

    2005-12-01

    Full Text Available Abstract Background Activation of Ras or Raf contributes to tumorigenesis of melanoma. However, constitutive Raf activation is also a characteristic of the majority of benign melanocytic nevi and high intensity signaling of either Ras or Raf was found to induce growth inhibition and senescence rather than transformation. Since the chromosome 3p kinase (3pK is a target of the Ras/Raf/Mek/Erk signaling pathway which antagonizes the function of the oncogene and anti-differentiation factor Bmi-1, 3pK may function as a tumor suppressor in tumors with constitutive Ras/Raf activation. Consequently, we tested whether inactivating 3pK mutations are present in melanoma. Methods 30 metastatic melanoma samples, which were positive for activating mutations of either BRaf or NRas, were analyzed for possible mutations in the 3pk gene. The 10 coding exons and their flanking intron sequences were amplified by PCR and direct sequencing of the PCR products was performed. Results This analysis revealed that besides the presence of some single nucleotide polymorphisms in the 3pk gene, we could not detect any possible loss of function mutation in any of these 30 metastatic melanoma samples selected for the presence of activating mutations within the Ras/Raf/Mek/Erk signaling pathway. Conclusion Hence, in melanoma with constitutively active Ras/Raf inactivating mutations within the 3pk gene do not contribute to the oncogenic phenotype of this highly malignant tumor.

  19. 78 FR 12130 - Social Security Ruling, SSR 13-3p; Appeal of an Initial Medical Disability Cessation...

    Science.gov (United States)

    2013-02-21

    ... Social Security--Disability Insurance; 96.004 Social Security--Survivors Insurance; 96.006 Supplemental... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Social Security Ruling, SSR 13-3p; Appeal of an Initial Medical Disability Cessation...

  20. $\\beta$3$p$-spectroscopy and proton-$\\gamma$ width determination in the decay of $^{31}$Ar

    CERN Multimedia

    We propose to perform a detailed study of the $\\beta$-decay of the dripline nucleus $^{31}$Ar. This will allow a detailed study of the $\\beta$-delayed 3$p$-decay as well as provide important information on the resonances of $^{30}$S and $^{29}$P, in particular the ratio between the $p$- and $\\gamma$- partial widths relevant for astrophysics.

  1. Reduced miR-659-3p Levels Correlate with Progranulin Increase in Hypoxic Conditions: Implications for Frontotemporal Dementia

    Science.gov (United States)

    Piscopo, Paola; Grasso, Margherita; Fontana, Francesca; Crestini, Alessio; Puopolo, Maria; Del Vescovo, Valerio; Venerosi, Aldina; Calamandrei, Gemma; Vencken, Sebastian F.; Greene, Catherine M.; Confaloni, Annamaria; Denti, Michela A.

    2016-01-01

    Progranulin (PGRN) is a secreted protein expressed ubiquitously throughout the body, including the brain, where it localizes in neurons and is activated microglia. Loss-of-function mutations in the GRN gene are an important cause of familial frontotemporal lobar degeneration (FTLD). PGRN has a neurotrophic and anti-inflammatory activity, and it is neuroprotective in several injury conditions, such as oxygen or glucose deprivation, oxidative injury, and hypoxic stress. Indeed, we have previously demonstrated that hypoxia induces the up-regulation of GRN transcripts. Several studies have shown microRNAs (miRNAs) involvement in hypoxia. Moreover, in FTLD patients with a genetic variant of GRN (rs5848), the reinforcement of miR-659-3p binding site has been suggested to be a risk factor. Here, we report that miR-659-3p interacts directly with GRN 3′UTR as shown by luciferase assay in HeLa cells and ELISA and Western Blot analysis in HeLa and Kelly cells. Moreover, we demonstrate the physical binding between GRN mRNA and miR-659-3p employing a miRNA capture-affinity technology in SK-N-BE and Kelly cells. In order to study miRNAs involvement in hypoxia-mediated up-regulation of GRN, we evaluated miR-659-3p levels in SK-N-BE cells after 24 h of hypoxic treatment, finding them inversely correlated to GRN transcripts. Furthermore, we analyzed an animal model of asphyxia, finding that GRN mRNA levels increased at post-natal day (pnd) 1 and pnd 4 in rat cortices subjected to asphyxia in comparison to control rats and miR-659-3p decreased at pnd 4 just when GRN reached the highest levels. Our results demonstrate the interaction between miR-659-3p and GRN transcript and the involvement of miR-659-3p in GRN up-regulation mediated by hypoxic/ischemic insults. PMID:27199656

  2. Identification of novel small molecule modulators of K2P18.1 two-pore potassium channel

    Science.gov (United States)

    Bruner, J. Kyle; Zou, Beiyan; Zhang, Hongkang; Zhang, Yixin; Schmidt, Katharina; Li, Min

    2014-01-01

    Two-pore domain potassium (K2P) channels are responsible for background potassium (K+) current, which is crucial for the maintenance of resting membrane potential. K2P18.1, also called TWIK-related spinal cord K+ channel (TRESK) or KCNK18, is thought to be a major contributor to background K+ currents, particularly in sensory neurons where it is abundantly expressed. Despite its critical role and potential therapeutic implication, pharmacological tools for probing K2P18.1 activity remain unavailable. Here, we report a high-throughput screen against a collection of bioactive compounds that yielded 26 inhibitors and 8 activators of K2P18.1 channel activity with more than 10-fold selectivity over the homologous channel K2P9.1. Among these modulators, the antihistamine loratadine inhibited K2P18.1 activity with IC50 of 0.49 ± 0.23 μM and is considerably more potent than existing K2P18.1 inhibitors. Importantly, the inhibition by loratadine remains equally efficacious upon potentiation of K2P18.1 by calcium signaling. Furthermore, the loratadine effect is dependent on transmembrane residues F145 and F352, providing orthogonal evidence that the inhibition is caused by a direct compound-channel interaction. This study reveals new pharmacological modulators of K2P18.1 activity useful in dissecting native K2P18.1 function. PMID:24972239

  3. Role of miR-222-3p in c-Src-Mediated Regulation of Osteoclastogenesis

    Directory of Open Access Journals (Sweden)

    Shinya Takigawa

    2016-02-01

    Full Text Available MicroRNAs (miRNAs are small non-coding RNAs that play a mostly post-transcriptional regulatory role in gene expression. Using RAW264.7 pre-osteoclast cells and genome-wide expression analysis, we identified a set of miRNAs that are involved in osteoclastogenesis. Based on in silico analysis, we specifically focused on miR-222-3p and evaluated its role in osteoclastogenesis. The results show that the inhibitor of miR-222-3p upregulated the mRNA levels of nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1 and tartrate-resistant acid phosphatase (TRAP, while its mimicking agent downregulated their mRNA levels. Western blot analysis showed that its inhibitor increased the protein levels of TRAP and cathepsin K, while its mimicking agent decreased their levels. Genome-wide mRNA expression analysis in the presence and absence of receptor activator of nuclear factor κ-B ligand (RANKL predicted c-Src as a potential regulatory target of miR-222-3p. Live cell imaging using a fluorescence resonance energy transfer (FRET technique revealed that miR-222-3p acted as an inhibitor of c-Src activity, and a partial silencing of c-Src suppressed RANKL-induced expression of TRAP and cathepsin K, as well as the number of multi-nucleated osteoclasts and their pit formation. Collectively, the study herein demonstrates that miR-222-3p serves as an inhibitor of osteoclastogenesis and c-Src mediates its inhibition of cathepsin K and TRAP.

  4. Circulating miR-221-3p as a novel marker for early prediction of acute myocardial infarction.

    Science.gov (United States)

    Coskunpinar, Ender; Cakmak, Huseyin Altug; Kalkan, Ali Kemal; Tiryakioglu, Necip Ozan; Erturk, Mehmet; Ongen, Zeki

    2016-10-10

    Recent studies have reported circulating microRNAs (miRNAs) as novel biomarkers for cardiovascular diseases including acute myocardial infarction, heart failure, diabetes mellitus, stroke, and acute pulmonary embolism. The aims of this study were 1) to compare the plasma expression levels of miRNAs in patients with acute coronary syndrome (ACS) and control subjects and in ST-elevation myocardial infarction (STEMI) and non-STEMI 2) to evaluate miRNAs potential to be used as novel diagnostic biomarkers for ACS. Twenty seven consecutive patients, admitted to emergency department of a training and research hospital between January-December 2013 with acute chest pain and/or dyspnea and diagnosed with ACS, and 16 non-ACS control subjects were included in this study. miRNA profiling was performed by using real time polymerase chain reaction. Functions of dysregulated miRNAs were evaluated by computerized-pathways analysis. miR-221-3p was one of the two most dysregulated miRNAs with a fold regulation of 3.89. It was significantly positively correlated with both Troponin and GRACE and Synthax Score. Moreover, miR221-3p was found to be significantly inversely correlated with left ventricular ejection fraction. miR-221-3p was the most prominent biomarker candidate with an area under curve (AUC) level of 0.881 (95% confidence interval: 0.774-0.987; p=0.002). The present study is the first to report an increased expression levels of miR-221-3p in AMI. Since miR-221-3p has a high discriminative value and significant relations with Troponin, GRACE and Synthax score and left ventricular systolic function, it may be a potential biomarker for early prediction of AMI. PMID:27374153

  5. MicroRNA-146b-3p Regulates Retinal Inflammation by Suppressing Adenosine Deaminase-2 in Diabetes

    Directory of Open Access Journals (Sweden)

    Sadanand Fulzele

    2015-01-01

    Full Text Available Hyperglycemia- (HG- Amadori-glycated albumin- (AGA- induced activation of microglia and monocytes and their adherence to retinal vascular endothelial cells contribute to retinal inflammation leading to diabetic retinopathy (DR. There is a great need for early detection of DR before demonstrable tissue damages become irreversible. Extracellular adenosine, required for endogenous anti-inflammation, is regulated by the interplay of equilibrative nucleoside transporter with adenosine deaminase (ADA and adenosine kinase. ADA, including ADA1 and ADA2, exists in all organisms. However, because ADA2 gene has not been identified in mouse genome, how diabetes alters adenosine-dependent anti-inflammation remains unclear. Studies of pig retinal microglia and human macrophages revealed a causal role of ADA2 in inflammation. Database search suggested miR-146b-3p recognition sites in the 3′-UTR of ADA2 mRNA. Coexpression of miR-146b-3p, but not miR-146-5p or nontargeting miRNA, with 3′-UTR of the ADA2 gene was necessary to suppress a linked reporter gene. In the vitreous of diabetic patients, decreased miR-146b-3p is associated with increased ADA2 activity. Ectopic expression of miR-146b-3p suppressed ADA2 expression, activity, and TNF-α release in the AGA-treated human macrophages. These results suggest a regulatory role of miR-146b-3p in diabetes related retinal inflammation by suppressing ADA2.

  6. Influence of van der Waals wells on the quantum scattering dynamics of the Cl(2P) + HCl → ClH + Cl(2P) reaction

    International Nuclear Information System (INIS)

    We investigate the influence of van der Waals wells on the quantum scattering dynamics of the Cl + HCl → ClH + Cl reaction in which the three electronic states that correlate asymptotically to the ground state of Cl(2P) + HCl(1Σ+) are included in the dynamical calculations. The short range region of the potential energy surfaces is taken from recent restricted open-shell coupled-cluster singles doubles with perturbative triples and multireference configuration-interaction ab initio computations of Dobbyn et al. [Phys. Chem. Chem. Phys. 1 (1999) 957], as refined by Whiteley et al. [Phys. Chem. Chem. Phys. 2 (2000) 549]. The long range van der Waals region of the potential surfaces is derived from multisurface empirical potentials due to Dubernet and Hutson [J. Phys. Chem. 98 (1994) 5844]. We manipulate the van der Waals portions of the global potential surfaces by scaling the interaction of the Cl quadrupole with the HCl multipoles. This results in van der Waals wells that are either deeper or shallower than the unscaled reference case. Spin-orbit coupling is included using a spin-orbit parameter that is assumed to be independent of nuclear geometry, and Coriolis interactions are calculated accurately. Reactive scattering calculations have been performed for total angular momentum quantum number, J=1/2, using a hyperspherical-coordinate coupled-channel method in full dimensionality. We investigate how the cumulative reaction probability and the fine-structure-resolved cumulative reaction probabilities are influenced by variations in the van der Waals wells

  7. Communication: Direct measurements of nascent O(3P0,1,2) fine-structure distributions and branching ratios of correlated spin-orbit resolved product channels CO(ã3Π; v) + O(3P0,1,2) and CO(tilde X{}^1Σ ^ + ; v) + O(3P0,1,2) in VUV photodissociation of CO2

    Science.gov (United States)

    Lu, Zhou; Chang, Yih Chung; Gao, Hong; Benitez, Yanice; Song, Yu; Ng, C. Y.; Jackson, W. M.

    2014-06-01

    We present a generally applicable experimental method for the direct measurement of nascent spin-orbit state distributions of atomic photofragments based on the detection of vacuum ultraviolet (VUV)-excited autoionizing-Rydberg (VUV-EAR) states. The incorporation of this VUV-EAR method in the application of the newly established VUV-VUV laser velocity-map-imaging-photoion (VMI-PI) apparatus has made possible the branching ratio measurement for correlated spin-orbit state resolved product channels, CO(ã3Π; v) + O(3P0,1,2) and CO(tilde X{}^1Σ ^ + ; v) + O(3P0,1,2), formed by VUV photoexcitation of CO2 to the 4s(101) Rydberg state at 97,955.7 cm-1. The total kinetic energy release (TKER) spectra obtained from the O+ VMI-PI images of O(3P0,1,2) reveal the formation of correlated CO(ã3Π; v = 0-2) with well-resolved v = 0-2 vibrational bands. This observation shows that the dissociation of CO2 to form the spin-allowed CO(ã3Π; v = 0-2) + O(3P0,1,2) channel has no potential energy barrier. The TKER spectra for the spin-forbidden CO(tilde X{}^1Σ ^ + ; v) + O(3P0,1,2) channel were found to exhibit broad profiles, indicative of the formation of a broad range of rovibrational states of CO(tilde X{}^1Σ ^ + ) with significant vibrational populations for v = 18-26. While the VMI-PI images for the CO(ã3Π; v = 0-2) + O(3P0,1,2) channel are anisotropic, indicating that the predissociation of CO2 4s(101) occurs via a near linear configuration in a time scale shorter than the rotational period, the angular distributions for the CO(tilde X{}^1Σ ^ + ; v) + O(3P0,1,2) channel are close to isotropic, revealing a slower predissociation process, which possibly occurs on a triplet surface via an intersystem crossing mechanism.

  8. Communication: direct measurements of nascent O((3)P0,1,2) fine-structure distributions and branching ratios of correlated spin-orbit resolved product channels CO(ã(3)Π; v) + O((3)P0,1,2) and CO(X̃(1)Σ(+); v) + O((3)P0,1,2) in VUV photodissociation of CO2.

    Science.gov (United States)

    Lu, Zhou; Chang, Yih Chung; Gao, Hong; Benitez, Yanice; Song, Yu; Ng, C Y; Jackson, W M

    2014-06-21

    We present a generally applicable experimental method for the direct measurement of nascent spin-orbit state distributions of atomic photofragments based on the detection of vacuum ultraviolet (VUV)-excited autoionizing-Rydberg (VUV-EAR) states. The incorporation of this VUV-EAR method in the application of the newly established VUV-VUV laser velocity-map-imaging-photoion (VMI-PI) apparatus has made possible the branching ratio measurement for correlated spin-orbit state resolved product channels, CO(ã(3)Π; v) + O((3)P0,1,2) and CO(X̃(1)Σ(+); v) + O((3)P0,1,2), formed by VUV photoexcitation of CO2 to the 4s(10 (1)) Rydberg state at 97,955.7 cm(-1). The total kinetic energy release (TKER) spectra obtained from the O(+) VMI-PI images of O((3)P0,1,2) reveal the formation of correlated CO(ã(3)Π; v = 0-2) with well-resolved v = 0-2 vibrational bands. This observation shows that the dissociation of CO2 to form the spin-allowed CO(ã(3)Π; v = 0-2) + O((3)P0,1,2) channel has no potential energy barrier. The TKER spectra for the spin-forbidden CO(X̃(1)Σ(+); v) + O((3)P0,1,2) channel were found to exhibit broad profiles, indicative of the formation of a broad range of rovibrational states of CO(X̃(1)Σ(+)) with significant vibrational populations for v = 18-26. While the VMI-PI images for the CO(ã(3)Π; v = 0-2) + O((3)P0,1,2) channel are anisotropic, indicating that the predissociation of CO2 4s(10 (1)) occurs via a near linear configuration in a time scale shorter than the rotational period, the angular distributions for the CO(X̃(1)Σ(+); v) + O((3)P0,1,2) channel are close to isotropic, revealing a slower predissociation process, which possibly occurs on a triplet surface via an intersystem crossing mechanism. PMID:24952514

  9. Affinity Purification and Characterization of a G-Protein Coupled Receptor, Saccharomyces cerevisiae Ste2p

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung-Kwon [University of Tennessee, Knoxville (UTK); Jung, Kyung-Sik [University of Tennessee, Knoxville (UTK); Son, Cagdas D [ORNL; Kim, Heejung [University of Tennessee, Knoxville (UTK); Verberkmoes, Nathan C [ORNL; Arshava, Boris [College of Staten Island; Naider, Fred [College of Staten Island; Becker, Jeffrey Marvin [ORNL

    2007-01-01

    We present a rare example of a biologically active G protein coupled receptor (GPCR) whose purity and identity were verified by mass spectrometry after being purified to near homogeneity from its native system. An overexpression vector was constructed to encode the Saccharomyces cerevisiae GPCR -factor receptor (Ste2p, the STE2 gene product) containing a 9-amino acid sequence of rhodopsin that served as an epitope/affinity tag. In the construct, two glycosylation sites and two cysteine residues were removed to aid future structural and functional studies. The receptor was expressed in yeast cells and was detected as a single band in a western blot indicating the absence of glycosylation. Tests of the epitope-tagged, mutated receptor showed it maintained its full biological activity. For extraction of Ste2p, yeast membranes were solubilized with 0.5 % n-dodecyl maltoside (DM). Approximately 120 g of purified -factor receptor was obtained per liter of culture by single-step affinity chromatography using a monoclonal antibody to the rhodopsin epitope. The binding affinity (Kd) of the purified -factor receptor in DM micelles was 28 nM as compared to Kd = 12.7 nM for Ste2p in cell membranes, and approximately 40 % of the purified receptor was correctly folded as judged by ligand saturation binding. About 50 % of the receptor sequence was retrieved from MALDITOF and nanospray mass spectrometry after CNBr digestion of the purified receptor. The methods described will enable structural studies of the -factor receptor and may provide an efficient technique to purify other GPCRs that have been functionally expressed in yeast.

  10. Glycogen Synthase Kinase 3 Phosphorylates RBL2/p130 during Quiescence

    OpenAIRE

    Litovchick, Larisa; Chestukhin, Anton; DeCaprio, James A.

    2004-01-01

    Phosphorylation of the retinoblastoma-related or pocket proteins RB1/pRb, RBL1/p107, and RBL2/p130 regulates cell cycle progression and exit. While all pocket proteins are phosphorylated by cyclin-dependent kinases (CDKs) during the G1/S-phase transition, p130 is also specifically phosphorylated in G0-arrested cells. We have previously identified several phosphorylated residues that match the consensus site for glycogen synthase kinase 3 (GSK3) in the G0 form of p130. Using small-molecule inh...

  11. Solvothermal synthesis and magnetic properties of β-Co2P nanorods

    OpenAIRE

    Li Tian; Liao Jun Peng; Wang Ying Feng

    2015-01-01

    Hexagonal high temperature phase β-Co2P nanorods with a diameter of around 50 nm were synthesized via a mild solvothermal route. The reaction was carried out at 180 °C using cobalt chloride hexahydrate (CoCl2 · 6H2O) as Co source and yellow phosphorous as P source. The composition, structure as well as morphology were characterized by X-ray diffraction (XRD), X-ray photoemission spectroscopy (XPS) and transmission electron microscopy (TEM). The magnetic susceptibility curve indicates that the...

  12. (p,2p) study of high-momentum components at 2.1 GeV

    International Nuclear Information System (INIS)

    A (p,2p) experiment designed to isolate interactions with small numbers of fast nuclear constituents is described. Special attention is paid to the experimental manifestation and description of a correlated pair of nucleons in the nucleus. Phase space calculations are presented for the proton-pair three-body final state and for final states with larger number of particles. The Two Armed Spectrometer System (TASS) is described in detail. The data suggest the possibility of isolating an interaction with one or two nucleons in the nucleus which may have momenta far in excess of those described in a Fermi gas model

  13. Acoustic and elastic properties of Sn(2)P(2)S(6) crystals.

    Science.gov (United States)

    Mys, O; Martynyuk-Lototska, I; Grabar, A; Vlokh, R

    2009-07-01

    We present the results concerned with acoustic and elastic properties of Sn(2)P(2)S(6) crystals. The complete matrices of elastic stiffness and compliance coefficients are determined in both the crystallographic coordinate system and the system associated with eigenvectors of the elastic stiffness tensor. The acoustic slowness surfaces are constructed and the propagation and polarization directions of the slowest acoustic waves promising for acousto-optic interactions are determined on this basis. The acoustic obliquity angle and the deviation of polarization of the acoustic waves from purely transverse or longitudinal states are quantitatively analysed. PMID:21828470

  14. Aneurysms of the P2P Segment of Posterior Cerebral Artery: Case Report and Surgical Steps

    Directory of Open Access Journals (Sweden)

    Paulo Aguiar

    2014-01-01

    Full Text Available The posterior cerebral artery (PCA is divided into 4 segments: precommunicating segment (P1, postcommunicating segment (P2, quadrigeminal segment (P3, and calcarine segment (P4. Small aneurysms are more prevalent than large aneurysms in patients with ruptured aneurysms. P2 and P3 aneurysms are usually managed by the subtemporal approach. This is a case report of rupture saccular aneurysm of posterior cerebral artery on P2P segment. The authors show the surgical steps of these rare aneurysms with an illustrative case.

  15. Pressure Induced Enhancement of Superconductivity in LaRu2P2

    OpenAIRE

    Baoxuan Li; Pengchao Lu; Jianzhong Liu; Jian Sun; Sheng Li; Xiyu Zhu; Hai-Hu Wen

    2016-01-01

    To explore new superconductors beyond the copper-based and iron-based systems is very important. The Ru element locates just below the Fe in the periodic table and behaves like the Fe in many ways. One of the common thread to induce high temperature superconductivity is to introduce moderate correlation into the system. In this paper, we report the significant enhancement of superconducting transition temperature from 3.84K to 5.77K by using a pressure only of 1.74 GPa in LaRu2P2 which has an...

  16. Relativistic model of 2p-2h meson exchange currents in (anti)neutrino scattering

    CERN Document Server

    Simo, I Ruiz; Barbaro, M B; De Pace, A; Caballero, J A; Donnelly, T W

    2016-01-01

    We develop a model of relativistic, charged meson-exchange currents (MEC) for neutrino-nucleus interactions. The two-body current is the sum of seagull, pion-in-flight, pion-pole and $\\Delta$-pole operators. These operators are obtained from the weak pion-production amplitudes for the nucleon derived in the non-linear $\\sigma$-model together with weak excitation of the $\\Delta(1232)$ resonance and its subsequent decay into $N\\pi$. With these currents we compute the five 2p-2h response functions contributing to $(\

  17. An Enhanced Search Technique for Managing Partial Coverage and Free Riding in P2P Networks

    CERN Document Server

    Thampi, Sabu M

    2010-01-01

    This paper presents a Q-learning based scheme for managing the partial coverage problem and the ill-effects of free riding in unstructured P2P networks. Based on various parameter values collected during query routing, reward for the actions are computed and these rewards are used for updating the corresponding Q-values of peers. Thus, the routing is done through only nodes which have shown high performance in the past. Simulation experiments are conducted in several times and the results are plotted. Results show that the proposed scheme effectively manages free riders, generates high hit ratio, reduces network traffic and manages partial coverage problem.

  18. Impact of lead ions on biosynthetic capacity of Streptomyces recifensis var. lyticus 2p-15 strain

    Directory of Open Access Journals (Sweden)

    Т. P. Kilochok

    2006-01-01

    Full Text Available The influence of different concentrations of Pb ions on biosynthetical ability of Streptomyces recifensis var. lyticus 2P-15, which is the producer of compound complex of extracellular enzymes and growth stimulators, was studied. It has been showed, that Pb ions introduced in agar medium have had a stimulative effect on production of surface and depth mycelia. The Pb ions, which have been inoculated into liquid fermentative medium in concentration of 1,0–2,0 mg/l realized directed synthesis of bacterio- and proteolytic enzymes, had an influence on qualitative and quantitative composition of produced enzymes.

  19. A Self-organized Public-Key Certificate System in P2P network

    Directory of Open Access Journals (Sweden)

    Zhen Luo

    2011-10-01

    Full Text Available P2P network is open, anonymous and dynamical in contrast with conventional network. It’s full of dishonesty, deceit, selfishness. It’s necessary to build a robust security infrastructure system.  The one important module of security infrastructure is to identify the users in transactions. This paper will propose an identification solution based on PKI. In our algorithm, the peer generates their public-private key pairs by themselves, issues certificates, and performs authentication without any centralized services. It can realize the identification, meanwhile keep peers anonymous. Moreover, it can limit the quantity of ID that a user applies for; alleviate the risk of Sybil attack.

  20. Towards an Effective Personalized Information Filter for P2P Based Focused Web Crawling

    OpenAIRE

    Fu Xiang-hua; Feng Bo-qin

    2006-01-01

    Information access is one of the hottest topics of information society, which has become even more important since the advent of the Web, but nowadays the general Web search engines still have no ability to find correct and timely information for individuals. In this paper, we propose a Peer-to-Peer (P2P) based decentralized focused Web crawling system called PeerBridge to provide user-centered, content-sensitive and personalized information search service from Web. The PeerBridge is built on...