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Sample records for 250-ghz gyrotron dnp

  1. A 250 GHz gyrotron with a 3 GHz tuning bandwidth for dynamic nuclear polarization.

    Science.gov (United States)

    Barnes, Alexander B; Nanni, Emilio A; Herzfeld, Judith; Griffin, Robert G; Temkin, Richard J

    2012-08-01

    We describe the design and implementation of a novel tunable 250 GHz gyrotron oscillator with >10 W output power over most of a 3 GHz band and >35 W peak power. The tuning bandwidth and power are sufficient to generate a >1 MHz nutation frequency across the entire nitroxide EPR lineshape for cross effect DNP, as well as to excite solid effect transitions utilizing other radicals, without the need for sweeping the NMR magnetic field. Substantially improved tunability is achieved by implementing a long (23 mm) interaction cavity that can excite higher order axial modes by changing either the magnetic field of the gyrotron or the cathode potential. This interaction cavity excites the rotating TE(₅,₂,q) mode, and an internal mode converter outputs a high-quality microwave beam with >94% Gaussian content. The gyrotron was integrated into a DNP spectrometer, resulting in a measured DNP enhancement of 54 on the membrane protein bacteriorhodopsin. PMID:22743211

  2. A 250 GHz gyrotron with a 3 GHz tuning bandwidth for dynamic nuclear polarization

    Science.gov (United States)

    Barnes, Alexander B.; Nanni, Emilio A.; Herzfeld, Judith; Griffin, Robert G.; Temkin, Richard J.

    2012-08-01

    We describe the design and implementation of a novel tunable 250 GHz gyrotron oscillator with >10 W output power over most of a 3 GHz band and >35 W peak power. The tuning bandwidth and power are sufficient to generate a >1 MHz nutation frequency across the entire nitroxide EPR lineshape for cross effect DNP, as well as to excite solid effect transitions utilizing other radicals, without the need for sweeping the NMR magnetic field. Substantially improved tunability is achieved by implementing a long (23 mm) interaction cavity that can excite higher order axial modes by changing either the magnetic field of the gyrotron or the cathode potential. This interaction cavity excites the rotating TE5,2,q mode, and an internal mode converter outputs a high-quality microwave beam with >94% Gaussian content. The gyrotron was integrated into a DNP spectrometer, resulting in a measured DNP enhancement of 54 on the membrane protein bacteriorhodopsin.

  3. A 250 GHz Gyrotron with a 3 GHz Tuning Bandwidth for Dynamic Nuclear Polarization

    OpenAIRE

    Barnes, Alexander B.; Nanni, Emilio A.; Herzfeld, Judith; Griffin, Robert G.; Temkin, Richard J.

    2012-01-01

    We describe the design and implementation of a novel tunable 250 GHz gyrotron oscillator with >10 W output power over most of a 3 GHz band and >35 W peak power. The tuning bandwidth and power are sufficient to generate a >1 MHz nutation frequency across the entire nitroxide EPR lineshape for cross effect DNP, as well as to excite solid effect transitions utilizing other radicals, without the need for sweeping the NMR magnetic field. Substantially improved tunability is achieved by implementin...

  4. Dynamic nuclear polarization at 9 T using a novel 250 GHz gyrotron microwave source

    Science.gov (United States)

    Bajaj, V. S.; Farrar, C. T.; Hornstein, M. K.; Mastovsky, I.; Vieregg, J.; Bryant, J.; Eléna, B.; Kreischer, K. E.; Temkin, R. J.; Griffin, R. G.

    2011-12-01

    In this communication, we report enhancements of nuclear spin polarization by dynamic nuclear polarization (DNP) in static and spinning solids at a magnetic field strength of 9 T (250 GHz for g = 2 electrons, 380 MHz for 1H). In these experiments, 1H enhancements of up to 170 ± 50 have been observed in 1- 13C-glycine dispersed in a 60:40 glycerol/water matrix at temperatures of 20 K; in addition, we have observed significant enhancements in 15N spectra of unoriented pf1-bacteriophage. Finally, enhancements of ˜17 have been obtained in two-dimensional 13C- 13C chemical shift correlation spectra of the amino acid U- 13C, 15N-proline during magic angle spinning (MAS), demonstrating the stability of the DNP experiment for sustained acquisition and for quantitative experiments incorporating dipolar recoupling. In all cases, we have exploited the thermal mixing DNP mechanism with the nitroxide radical 4-amino-TEMPO as the paramagnetic dopant. These are the highest frequency DNP experiments performed to date and indicate that significant signal enhancements can be realized using the thermal mixing mechanism even at elevated magnetic fields. In large measure, this is due to the high microwave power output of the 250 GHz gyrotron oscillator used in these experiments.

  5. Dynamic nuclear polarization at 9 T using a novel 250 GHz gyrotron microwave source

    OpenAIRE

    Bajaj, V. S.; Farrar, C. T.; Hornstein, M.K.; Mastovsky, I.; Vieregg, J.; Bryant, J; Eléna, B.; Kreischer, K.E.; Temkin, R.J.; Griffin, R G

    2003-01-01

    In this communication, we report enhancements of nuclear spin polarization by dynamic nuclear polarization (DNP) in static and spinning solids at a magnetic field strength of 9 T (250 GHz for g = 2 electrons, 380 MHz for [superscript 1]H). In these experiments, [superscript 1]H enhancements of up to 170 ± 50 have been observed in 1-[superscript 13]C-glycine dispersed in a 60:40 glycerol/water matrix at temperatures of 20 K; in addition, we have observed significant enhancements in [superscrip...

  6. The Development of 460 GHz gyrotrons for 700 MHz DNP-NMR spectroscopy

    Science.gov (United States)

    Idehara, T.; Tatematsu, Y.; Yamaguchi, Y.; Khutoryan, E. M.; Kuleshov, A. N.; Ueda, K.; Matsuki, Y.; Fujiwara, T.

    2015-07-01

    Two demountable gyrotrons with internal mode converters were developded as sub-THz radiation sources for 700 MHz DNP (Dynamic Nuclear Polarization) enhanced NMR spectroscopy. Experimental study on the DNP-NMR spectroscopy will be carried out in Osaka University, Institute for Protein Research, as a collaboration with FIR UF. Both gyrotrons operate near 460 GHz and the output CW power measured at the end of transmission system made by circular waveguides is typically 20 to 30 watts. One of them named Gyrotron FU CW GVI (we are using "Gyrotron FU CW GO-1" as an official name in Osaka University) is designed to have a special function of high speed frequency modulation δ f within 100 MHz band. This will expand excitable band width of ESR and increase the number of electron spins contributing to DNP. The other gyrotron, Gyrotron FU CW GVIA ("Gyrotron FU CW GO-II") has a function of frequency tunability Δ f in the range of wider than 1.5 GHz, which is achieved in steady state by changing magnetic field intensity. This function should be used for adjusting the output frequency at the optimal value to achieve the highest enhancement factor of DNP.

  7. 500-fold enhancement of in situ 13C liquid state NMR using gyrotron-driven temperature-jump DNP

    Science.gov (United States)

    Yoon, Dongyoung; Soundararajan, Murari; Caspers, Christian; Braunmueller, Falk; Genoud, Jérémy; Alberti, Stefano; Ansermet, Jean-Philippe

    2016-09-01

    A 550-fold increase in the liquid state 13C NMR signal of a 50 μL sample was obtained by first hyperpolarizing the sample at 20 K using a gyrotron (260 GHz), then, switching its frequency in order to apply 100 W for 1.5 s so as to melt the sample, finally, turning off the gyrotron to acquire the 13C NMR signal. The sample stays in its NMR resonator, so the sequence can be repeated with rapid cooling as the entire cryostat stays cold. DNP and thawing of the sample are performed only by the switchable and tunable gyrotron without external devices. Rapid transition from DNP to thawing in one second time scale was necessary especially in order to enhance liquid 1H NMR signal.

  8. Gyrotrons

    International Nuclear Information System (INIS)

    The purpose of this study is to bring together some relevant ideas and developments in the field of gyrotrons. The development of the electron cyclotron resonance maser (ECRM or Gyrotron) was an important break through in microwave electronics in the 1970s. As we look to the 1980's, we find scientists channelling their collective efforts to shorten the wavelength and increase output power and efficiency, thereby yielding an important device for generating high power microwave radiation. 24 refs

  9. Further Characterization of 394-GHz Gyrotron FU CW GII with Additional PID Control System for 600-MHz DNP-SSNMR Spectroscopy

    Science.gov (United States)

    Ueda, Keisuke; Matsuki, Yoh; Fujiwara, Toshimichi; Tatematsu, Yoshinori; Ogawa, Isamu; Idehara, Toshitaka

    2016-09-01

    A 394-GHz gyrotron, FU CW GII, has been designed at the University of Fukui, Japan, for dynamic nuclear polarization (DNP)-enhanced solid-state nuclear magnetic resonance (SSNMR) experiments at 600-MHz 1H resonant frequency. After installation at the Institute for Protein Research (IPR), Osaka University, Japan, a PID feedback control system was equipped to regulate the electron gun heater current for stabilization of the electron beam current, which ultimately achieved stabilization of output power when operating in continuous wave (CW) mode. During exploration to further optimize operating conditions, a continuous tuning bandwidth of approximately 1 GHz was observed by varying the operating voltage at a fixed magnetic field. In the frequency range required for positive DNP enhancement, the output power was improved by increasing the magnetic field and the operating voltage from their initial operational settings. In addition, fine tuning of output frequency by varying the cavity cooling water temperature was demonstrated. These operating conditions and ancillary enhancements are expected to contribute to further enhancement of SSNMR signal.

  10. Further Characterization of 394-GHz Gyrotron FU CW GII with Additional PID Control System for 600-MHz DNP-SSNMR Spectroscopy

    Science.gov (United States)

    Ueda, Keisuke; Matsuki, Yoh; Fujiwara, Toshimichi; Tatematsu, Yoshinori; Ogawa, Isamu; Idehara, Toshitaka

    2016-04-01

    A 394-GHz gyrotron, FU CW GII, has been designed at the University of Fukui, Japan, for dynamic nuclear polarization (DNP)-enhanced solid-state nuclear magnetic resonance (SSNMR) experiments at 600-MHz 1H resonant frequency. After installation at the Institute for Protein Research (IPR), Osaka University, Japan, a PID feedback control system was equipped to regulate the electron gun heater current for stabilization of the electron beam current, which ultimately achieved stabilization of output power when operating in continuous wave (CW) mode. During exploration to further optimize operating conditions, a continuous tuning bandwidth of approximately 1 GHz was observed by varying the operating voltage at a fixed magnetic field. In the frequency range required for positive DNP enhancement, the output power was improved by increasing the magnetic field and the operating voltage from their initial operational settings. In addition, fine tuning of output frequency by varying the cavity cooling water temperature was demonstrated. These operating conditions and ancillary enhancements are expected to contribute to further enhancement of SSNMR signal.

  11. Design of an electronically tunable millimeter wave Gyrotron Backward Wave Oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Caplan, M.

    1987-01-01

    A non-linear self-consistent computer simulation code is used to analyze the saturated output of the Gyrotron Backward Wave Oscillator (Gyro BWO) which can be used as a tunable driver for a 250 GHz FEL amplifier. Simulations show that the Gyrotron BWO using a Pierce/Wiggler gun configuration can produce at least 10 kW of microwave power over the range 249 GHz to 265 GHz by varying beam voltage alone.

  12. First demonstration of a vehicle mounted 250GHz real time passive imager

    Science.gov (United States)

    Mann, Chris

    2009-05-01

    This paper describes the design and performance of a ruggedized passive Terahertz imager, the frequency of operation is a 40GHz band centred around 250GHz. This system has been specifically targeted at vehicle mounted operation, outdoors in extreme environments. The unit incorporates temperature stabilization along with an anti-vibration chassis and is sealed to allow it to be used in a dusty environment. Within the system, a 250GHz heterodyne detector array is mated with optics and scanner to allow real time imaging out to 100 meters. First applications are envisaged to be stand-off, person borne IED detection to 30 meters but the unique properties in this frequency band present other potential uses such as seeing through smoke and fog. The possibility for use as a landing aid is discussed. A detailed description of the system design and video examples of typical imaging output will be presented.

  13. A 250 GHz Survey of High Redshift QSOs from the Sloan Digital Sky Survey

    CERN Document Server

    Carilli, C L; Rupen, M P; Fan, X; Strauss, M A; Menten, K M; Kreysa, E; Schneider, D P; Bertarini, A; Yun, M S; Zylka, R; Fan, Xiaohui; Strauss, Michael A.; Schneider, Donald P.

    2001-01-01

    We present observations at 250 GHz (1.2 mm), 43 GHz, and 1.4 GHz of a sample of 41 QSOs at z > 3.7 found in the Sloan Digital Sky Survey. We detect 16 sources with a 250 GHz flux density greater than 1.4 mJy. The combination of centimeter and millimeter wavelength observations indicates that the 250 GHz emission is most likely thermal dust emission. Assuming a dust temperature of 50 K, the implied dust masses for the 16 detected sources are in the range 1.5e8 to 5.9e8 Msun, and the dust emitting regions are likely to be larger than 1 kpc in extent. The radio-through-optical spectral energy distributions for these sources are within the broad range defined by lower redshift, lower optical luminosity QSOs. We consider possible dust heating mechanisms, including UV emission from the active nucleus (AGN) and a starburst concurrent with the AGN, with implied star formation rates between 500 and 2000 Msun/year.

  14. A 250-GHz CARM [Cyclotron Auto Resonance Maser] oscillator experiment driven by an induction linac

    International Nuclear Information System (INIS)

    A 250-GHz Cyclotron Auto Resonance Maser (CARM) oscillator has been designed and constructed and will be tested using a 1-kA, 2-MeV electron beam produced by the induction linac at the Accelerator Research Center (ARC) facility of Lawrence Livermore National Laboratory (LLNL). The oscillator circuit was made to operate in the TE11 mode at ten times cutoff using waveguide Bragg reflectors to create an external cavity Q of 8000. Theory predicts cavity fill times of less than 30 ns (pulse length) and efficiencies approaching 20% is sufficiently low transverse electron velocity spreads are maintained (2%)

  15. Advanced instrumentation for DNP-enhanced MAS NMR for higher magnetic fields and lower temperatures

    Science.gov (United States)

    Matsuki, Yoh; Idehara, Toshitaka; Fukazawa, Jun; Fujiwara, Toshimichi

    2016-03-01

    Sensitivity enhancement of MAS NMR using dynamic nuclear polarization (DNP) is gaining importance at moderate fields (B0 90 K) with potential applications in chemistry and material sciences. However, considering the ever-increasing size and complexity of the systems to be studied, it is crucial to establish DNP under higher field conditions, where the spectral resolution and the basic NMR sensitivity tend to improve. In this perspective, we overview our recent efforts on hardware developments, specifically targeted on improving DNP MAS NMR at high fields. It includes the development of gyrotrons that enable continuous frequency tuning and rapid frequency modulation for our 395 GHz-600 MHz and 460 GHz-700 MHz DNP NMR spectrometers. The latter 700 MHz system involves two gyrotrons and a quasi-optical transmission system that combines two independent sub-millimeter waves into a single dichromic wave. We also describe two cryogenic MAS NMR probe systems operating, respectively, at T ∼100 K and ∼30 K. The latter system utilizes a novel closed-loop helium recirculation mechanism, achieving cryogenic MAS without consuming any cryogen. These instruments altogether should promote high-field DNP toward more efficient, reliable and affordable technology. Some experimental DNP results obtained with these instruments are presented.

  16. Simplified THz Instrumentation for High-Field DNP-NMR Spectroscopy.

    Science.gov (United States)

    Maly, Thorsten; Sirigiri, Jagadishwar R

    2012-07-01

    We present an alternate simplified concept to irradiate a nuclear magnetic resonance sample with terahertz (THz) radiation for dynamic nuclear polarization (DNP) experiments using the TE(01) circular waveguide mode for transmission of the THz power and the illumination of the DNP sample by either the TE(01) or TE(11) mode. Using finite element method and 3D electromagnetic simulations we demonstrate that the average value of the transverse magnetic field induced by the THz radiation and responsible for the DNP effect using the TE(11) or the TE(01) mode are comparable to that generated by the HE(11) mode and a corrugated waveguide. The choice of the TE(11)/TE(01) mode allows the use of a smooth-walled, oversized waveguide that is easier to fabricate and less expensive than a corrugated waveguide required for transmission of the HE(11) mode. Also, the choice of the TE(01) mode can lead to a simplification of gyrotron oscillators that operate in the TE(0n) mode, by employing an on-axis rippled-wall mode converter to convert the TE(0n) mode into the TE(01) mode either inside or outside of the gyrotron tube. These novel concepts will lead to a significant simplification of the gyrotron, the transmission line and the THz coupler, which are the three main components of a DNP system. PMID:22977293

  17. DNP Communication Function with RTDS

    DEFF Research Database (Denmark)

    Cha, Seung-Tae; Wu, Qiuwei; Saleem, Arshad

    2010-01-01

    A simulation case is implemented on RSCAD for testing their communication. The case has two binary status points (mapped to DNP binary input objects 1 & 2) and two binary control points (mapped to DNP binary output objects 10 and controlled via DNP objects 12). There is also one analog status poi...

  18. Operational Characteristics of a 14-W 140-GHz Gyrotron for Dynamic Nuclear Polarization

    OpenAIRE

    Joye, Colin D.; Griffin, Robert G.; Hornstein, Melissa K.; Hu, Kan-Nian; Kreischer, Kenneth E.; Rosay, Melanie; Shapiro, Michael A; Sirigiri, Jagadishwar R.; Temkin, Richard J.; Woskov, Paul P.

    2006-01-01

    The operating characteristics of a 140-GHz 14-W long pulse gyrotron are presented. The device is being used in dynamic nuclear polarization enhanced nuclear magnetic resonance (DNP/NMR) spectroscopy experiments. The gyrotron yields 14 W peak power at 139.65 GHz from the TE(0,3) operating mode using a 12.3-kV 25-mA electron beam. Additionally, up to 12 W peak has been observed in the TE(2,3) mode at 136.90 GHz. A series of mode converters transform the TE(0,3) operating mode to the TE(1,1) mod...

  19. Gyrotrons for High-Power Terahertz Science and Technology at FIR UF

    CERN Document Server

    Idehara, Toshitaka

    2016-01-01

    In this paper, we present the recent progress in the development of a series of gyrotrons at FIR UF that have opened the road to many novel applications in the high-power Terahertz science and technology. The current status of the research in this actively developing field is illustrated by the most representative examples in which the developed gyrotrons are used as powerful and frequency tunable sources of coherent radiation operating in a CW regime. Among them are high-precision spectroscopic techniques (most notably DNP-NMR, ESR, XDMR, and studies of the hyperfine splitting of the energy levels of positronium), treatment and characterization of advanced materials, new medical technologies.

  20. High-harmonic gyrotrons

    Science.gov (United States)

    McDermott, D. B.; Luhmann, N. C., Jr.

    1984-08-01

    There is currently much interest in the development of moderate to high power (1 kW - 1 MW) millimeter wave sources. Considered applications are mainly related to radar and communication systems. There are, however, also applications in plasma diagnostics, heating, and the nondestructive testing of dielectrics. The dominant source of high-power, high-frequency radiation has become the gyrotron. Jory et al. (1983) have reported operation of a 60 GHz, CW gyrotron, producing output powers in excess of 200 kW. High power, compact submillimeter-wave sources have become possible by making use of the concept of a high-harmonic gyrotron, in which the magnetic field can be reduced by an order of magnitude. Attention is given to synchronism, negative-mass instability, energy requirements, oscillators, efficiency, high power, dielectric loading, the peniotron, and amplifiers.

  1. Experimental tests of a 263 GHz gyrotron for spectroscopic applications and diagnostics of various media

    Energy Technology Data Exchange (ETDEWEB)

    Glyavin, M. Yu., E-mail: glyavin@appl.sci-nnov.ru; Denisov, G. G.; Zapevalov, V. E. [Institute of Applied Physics, Russian Academy of Sciences, Nizhny Novgorod (Russian Federation); Gycom Ltd., Nizhny Novgorod (Russian Federation); Chirkov, A. V.; Fokin, A. P.; Kholoptsev, V. V.; Kuftin, A. N.; Luchinin, A. G.; Golubyatnikov, G. Yu.; Malygin, V. I.; Morozkin, M. V.; Manuilov, V. N.; Proyavin, M. D.; Sedov, A. S.; Tsvetkov, A. I. [Institute of Applied Physics, Russian Academy of Sciences, Nizhny Novgorod (Russian Federation); Sokolov, E. V.; Tai, E. M. [Gycom Ltd., Nizhny Novgorod (Russian Federation)

    2015-05-15

    A 263 GHz continuous-wave (CW) gyrotron was developed at the IAP RAS for future applications as a microwave power source in Dynamic Nuclear Polarization / Nuclear magnetic resonance (DNP/NMR) spectrometers. A new experimental facility with a computerized control was built to test this and subsequent gyrotrons. We obtained the maximum CW power up to 1 kW in the 15 kV/0.4 A operation regime. The power about 10 W, which is sufficient for many spectroscopic applications, was realized in the low current 14 kV/0.02 A regime. The possibility of frequency tuning by variation of the coolant temperature about 4 MHz/1 °C was demonstrated. The spectral width of the gyrotron radiation was about 10{sup −6}.

  2. An integrated gyrotron controller

    Energy Technology Data Exchange (ETDEWEB)

    Michel, Georg, E-mail: michel@ipp.mpg.de; Sachtleben, Juergen

    2011-10-15

    The ECRH system of W7-X is composed of 10 independent gyrotron modules. Each module consists of one gyrotron and its peripherals such as power supplies, cooling plants and distributed PLC systems. The fast real-time control functions such as the timing of the two high voltage supplies, trigger pulses, protection, modulation and communication with the central control of W7-X, is implemented in an integrated controller which is described in this paper. As long-term maintainability and sustainability are important for nuclear fusion experiments, the choice fell on an FPGA-based design which is exclusively based on free (as in 'freedom') software and configuration code. The core of the controller consists of a real-time Java virtual machine (JVM) that provides the TCP-IP connectivity as well as more complicated control functions, and which interacts with the gyrotron-specific hardware. Both the gyrotron-specific hardware and the JVM are implemented on the same FPGA, which is the main component of the controller. All 10 controllers are currently completed and operational. All parameters and functions are accessible via Ethernet. Due to the open, FPGA-based design, most hardware modifications can be made via the network as well. This paper discusses the capabilities of the controllers and their integration into the central W7-X control.

  3. Gyrotron oscillators for fusion heating

    International Nuclear Information System (INIS)

    Recent experiments have been performed to determine the ultimate power capability of a 28 GHz 200 kW CW gyrotron design. A power output of 342 kW CW was measured in these tests with an efficiency of 37%. Progress in the development of 60 GHz 200 kW pulsed and CW gyrotrons is discussed. An output of 200 kW with 100 msec pulse length has been achieved with the pulsed design

  4. Results of 170 GHz gyrotron tests

    International Nuclear Information System (INIS)

    During the last few years the development of 170 GHz gyrotron for ITER have been under way. Sketchy description of experiment and test results of an improved design gyrotron with a depressed collector, are reported. The analysis of the phenomena causing the destruction of the output window is submitted. The projects for the following experiments are presented. The new 170 GHz/1 MW/50%/CW gyrotron with depressed collector and CVD diamond window was developed by GYCOM. This gyrotron was tested with BN window and then with diamond window. The gyrotron testing showed that practically all ITER requirements are satisfied except of pulse duration limited to that time by brick load arcing. Imperfection of arc protection system gave the possibility for arc-plasma to come to the window and destroy it. New loads have been created and tested at 140 GHz, with output gyrotron power Phf = 820 kW and the pulse duration T = 3.5 s. A new version of protection system has been developed and tested in experiment. The next gyrotron with modified electron gun has been manufactured. After first stage test, BN window will be replaced with new CVD diamond unit, which is assembling now. Testing of this gyrotron is planned to carry out in May 2002. (authors)

  5. Ultra-low temperature MAS-DNP

    Science.gov (United States)

    Lee, Daniel; Bouleau, Eric; Saint-Bonnet, Pierre; Hediger, Sabine; De Paëpe, Gaël

    2016-03-01

    Since the infancy of NMR spectroscopy, sensitivity and resolution have been the limiting factors of the technique. Regular essential developments on this front have led to the widely applicable, versatile, and powerful spectroscopy that we know today. However, the Holy Grail of ultimate sensitivity and resolution is not yet reached, and technical improvements are still ongoing. Hence, high-field dynamic nuclear polarization (DNP) making use of high-frequency, high-power microwave irradiation of electron spins has become very promising in combination with magic angle sample spinning (MAS) solid-state NMR experiments. This is because it leads to a transfer of the much larger polarization of these electron spins under suitable irradiation to surrounding nuclei, greatly increasing NMR sensitivity. Currently, this boom in MAS-DNP is mainly performed at minimum sample temperatures of about 100 K, using cold nitrogen gas to pneumatically spin and cool the sample. This Perspective deals with the desire to improve further the sensitivity and resolution by providing "ultra"-low temperatures for MAS-DNP, using cryogenic helium gas. Different designs on how this technological challenge has been overcome are described. It is shown that stable and fast spinning can be attained for sample temperatures down to 30 K using a large cryostat developed in our laboratory. Using this cryostat to cool a closed-loop of helium gas brings the additional advantage of sample spinning frequencies that can greatly surpass those achievable with nitrogen gas, due to the differing fluidic properties of these two gases. It is shown that using ultra-low temperatures for MAS-DNP results in substantial experimental sensitivity enhancements and according time-savings. Access to this temperature range is demonstrated to be both viable and highly pertinent.

  6. Towards Overhauser DNP in supercritical CO2

    Science.gov (United States)

    van Meerten, S. G. J.; Tayler, M. C. D.; Kentgens, A. P. M.; van Bentum, P. J. M.

    2016-06-01

    Overhauser Dynamic Nuclear Polarization (ODNP) is a well known technique to improve NMR sensitivity in the liquid state, where the large polarization of an electron spin is transferred to a nucleus of interest by cross-relaxation. The efficiency of the Overhauser mechanism for dipolar interactions depends critically on fast local translational dynamics at the timescale of the inverse electron Larmor frequency. The maximum polarization enhancement that can be achieved for 1H at high magnetic fields benefits from a low viscosity solvent. In this paper we investigate the option to use supercritical CO2 as a solvent for Overhauser DNP. We have investigated the diffusion constants and longitudinal nuclear relaxation rates of toluene in high pressure CO2. The change in 1H T1 by addition of TEMPO radical was analyzed to determine the Overhauser cross-relaxation in such a mixture, and is compared with calculations based on the Force Free Hard Sphere (FFHS) model. By analyzing the relaxation data within this model we find translational correlation times in the range of 2-4 ps, depending on temperature, pressure and toluene concentration. Such short correlation times may be instrumental for future Overhauser DNP applications at high magnetic fields, as are commonly used in NMR. Preliminary DNP experiments have been performed at 3.4 T on high pressure superheated water and model systems such as toluene in high pressure CO2.

  7. Towards Overhauser DNP in supercritical CO2.

    Science.gov (United States)

    van Meerten, S G J; Tayler, M C D; Kentgens, A P M; van Bentum, P J M

    2016-06-01

    Overhauser Dynamic Nuclear Polarization (ODNP) is a well known technique to improve NMR sensitivity in the liquid state, where the large polarization of an electron spin is transferred to a nucleus of interest by cross-relaxation. The efficiency of the Overhauser mechanism for dipolar interactions depends critically on fast local translational dynamics at the timescale of the inverse electron Larmor frequency. The maximum polarization enhancement that can be achieved for (1)H at high magnetic fields benefits from a low viscosity solvent. In this paper we investigate the option to use supercritical CO2 as a solvent for Overhauser DNP. We have investigated the diffusion constants and longitudinal nuclear relaxation rates of toluene in high pressure CO2. The change in (1)H T1 by addition of TEMPO radical was analyzed to determine the Overhauser cross-relaxation in such a mixture, and is compared with calculations based on the Force Free Hard Sphere (FFHS) model. By analyzing the relaxation data within this model we find translational correlation times in the range of 2-4ps, depending on temperature, pressure and toluene concentration. Such short correlation times may be instrumental for future Overhauser DNP applications at high magnetic fields, as are commonly used in NMR. Preliminary DNP experiments have been performed at 3.4T on high pressure superheated water and model systems such as toluene in high pressure CO2.

  8. Structural biology applications of solid state MAS DNP NMR

    Science.gov (United States)

    Akbey, Ümit; Oschkinat, Hartmut

    2016-08-01

    Dynamic Nuclear Polarization (DNP) has long been an aim for increasing sensitivity of nuclear magnetic resonance (NMR) spectroscopy, delivering spectra in shorter experiment times or of smaller sample amounts. In recent years, it has been applied in magic angle spinning (MAS) solid-state NMR to a large range of samples, including biological macromolecules and functional materials. New research directions in structural biology can be envisaged by DNP, facilitating investigations on very large complexes or very heterogeneous samples. Here we present a summary of state of the art DNP MAS NMR spectroscopy and its applications to structural biology, discussing the technical challenges and factors affecting DNP performance.

  9. Analytic theory of the gyrotron

    International Nuclear Information System (INIS)

    An analytic theory is derived for a gyrotron operating in the linear gain regime. The gyrotron is a coherent source of microwave and millimeter wave radiation based on an electron beam emitting at cyclotron resonance Ω in a strong, uniform magnetic field. Relativistic equations of motion and first order perturbation theory are used. Results are obtained in both laboratory and normalized variables. An expression for cavity threshold gain is derived in the linear regime. An analytic expression for the electron phase angle in momentum space shows that the effect of the RF field is to form bunches that are equal to the unperturbed transit phase plus a correction term which varies as the sine of the input phase angle. The expression for the phase angle is plotted and bunching effects in and out of phase (0 and -π) with respect to the RF field are evident for detunings leading to gain and absorption, respectively. For exact resonance, field frequency ω = Ω, a bunch also forms at a phase of -π/2. This beam yields the same energy exchange with the RF field as an unbunched, (nonrelativistic) beam. 6 refs., 10 figs

  10. Solid Effect DNP in a Rapid-melt setup.

    Science.gov (United States)

    van Bentum, P J M; Sharma, M; van Meerten, S G J; Kentgens, A P M

    2016-02-01

    Dynamic Nuclear Polarization (DNP) has become a key element in nuclear magnetic resonance (NMR). Recently, we developed a novel approach to DNP enhanced liquid-state NMR based on rapid melting of a solid hyperpolarized sample followed by 'in situ' liquid-state NMR detection. This method allows (1)H detection with fast cycling options for signal averaging. In nonpolar solvents, doped with BDPA radicals, proton enhancement factors were achieved of up to 400. A short recycling delay of about 5s allows for a fast determination of the hyper-polarization dynamics as function of the microwave frequency and power. Here, we use the rapid melt dnp method to study the mechanisms for DNP in the solid phase in more detail. Solid Effect, Cross Effect, Solid Overhauser and Liquid-state (supercritical) Overhauser DNP enhancement can be observed in the same setup. In this paper, we concentrate on Solid Effect DNP observed with both homogeneous narrow line radicals such as BDPA and with wide line anisotropic nitroxide radicals such as TEMPOL. We find indications that BDPA protons play an important role in Solid Effect DNP with this radical. A simplified spin diffusion model for BDPA can give a semi-quantitative description of the enhancements as function of the microwave power and as function of the proton concentration in the solid solution. For aqueous frozen samples we observe a similar Solid Effect DNP enhancement, which is analyzed within the simplified spin diffusion model.

  11. Recent result of gyrotron operation in NIFS

    Directory of Open Access Journals (Sweden)

    Ito Satoshi

    2015-01-01

    Full Text Available In the last Large Helical Device (LHD experimental campaign, a 154GHz gyrotron which had been conditioned to generate 1 MW/2 s, 0.5 MW/CW was installed for LHD experiments. Four high power gyrotrons (three-77 GHz/1~1.5 MW and one-154 GHz/1 MW and a CW gyrotron (84 GHz/0.2 MW are ready. Our experiment requires high energy and various injection patterns for Electron Cyclotron Resonance Heating (ECRH. Higher individual injection power and various injection patterns, we developed a power enhancement method by stepped anode acceleration voltage control and operated the gyrotron in the hard excitation region. These operations were realized by a remote controlled waveform generator. However the oscillation map of high power or long pulse operation in the hard excitation region were limited because in order to achieve the hard excitation region by the anode voltage control one must pass through the high anode current phase within a time short enough that the anode or the anode power supply is not overloaded. This limitation becomes more critical when the gyrotron beam current is increased in order to increase the output power. In the long pulse operation it was impossible to reach the hard excitation region in a low beam current (<10A.

  12. The 110 GHz Gyrotron System on DIII-D: Gyrotron Tests and Physics Results

    International Nuclear Information System (INIS)

    The DIII-D tokamak has installed a system with three gyrotrons at the 1 MW level operating at 110 GHz. Physics experiments on electron cyclotron current drive, heating, and transport have been performed. Good efficiency has been achieved both for on-axis and off-axis current drive with relevance for control of the current density profile leading to advanced regimes of tokamak operation, although there is a difference between off-axis ECCD efficiency inside and outside the magnetic axis. Heating efficiency is excellent and electron temperatures up to 10 keV have been achieved. The gyrotron system is versatile, with poloidal scan and control of the polarization of the injected rf beam. Phase correcting mirrors form a Gaussian beam and focus it into the waveguide. Both perpendicular and oblique launch into the tokamak have been used. Three different gyrotron designs are installed and therefore unique problems specific to each have been encountered, including parasitic oscillations, mode hops during modulation and polarization control problems. Two of the gyrotrons suffered damage during operations, one due to filament failure and one due to a vacuum leak. The repairs and subsequent testing will be described. The transmission system uses evacuated, windowless waveguide and the three gyrotrons have output windows of three different materials. One gyrotron uses a diamond window and generates a Gaussian beam directly. The development of the system and specific tests and results from each of the gyrotrons will be presented. The DIII-D project has committed to an upgrade of the system, which will add three gyrotrons in the 1 MW class, all using diamond output windows, to permit operation at up to ten seconds per pulse at one megawatt output for each gyrotron

  13. Enhanced performance large volume dissolution-DNP

    DEFF Research Database (Denmark)

    Bowen, Sean; Ardenkjær-Larsen, Jan Henrik

    2014-01-01

    A systematic study of the performance of the dissolution process in dissolution-DNP is presented. A relatively simple set of modifications is made to the standard Hypersense dissolution system to enable polarization of large volume samples. These consist of a large volume sample cup along...... with supporting modifications to the dissolution head and related components. Additional modifications were made to support the mapping of the temperature/pressure space of the dissolution process as well as enabling the use of large volumes of solvent and improving the robustness of the system. No loss...... of polarization was observed as sample size was increased to the 1g capacity of the large volume cup and for a dilution factor as low as 1:10....

  14. Calorimetric Power Measurements of the DIII-D Gyrotron System

    Science.gov (United States)

    Gorelov, I.; Lohr, J.; Callis, R. W.; Cary, W. P.; Ponce, D.; Pinsker, R. I.; Chiu, H.; Baity, F. W.

    2001-10-01

    Gyrotron power measurements are an integral part of rf experiments on DIII-D. The ECH complex at General Atomics is built up from four 110 GHz, 1 MW gyrotrons, one from Communication and Power Industry (CPI) and three from Russia's Gyrotron Company (Gycom). Power measurements are made calorimetrically using the temperature and flow measurements of the gyrotron cooling circuits. Three such circuits are measured on the Gycom gyrotrons: window, MOU and dummy load. Interior cooling circuits are additionally measured on the CPI gyrotron that are very useful when tuning for maximum power and efficiency. Calorimetric signals from each cooling circuit are acquired by computer, where the dissipated energy is calculated with a LabView program. From these calculations, total rf power and efficiency were determined. Thus, calorimetry measurements were effectuated during gyrotron operations to provide the average power of each pulse.

  15. Start currents in an overmoded gyrotron

    Science.gov (United States)

    Yeddulla, M.; Nusinovich, G. S.; Antonsen, T. M.

    2003-11-01

    High-power long-pulse millimeter-wave gyrotrons operate in high-order modes. The spectral density of these modes is very high. Therefore, self-excitation conditions can be fulfilled for several modes simultaneously. Correspondingly, in order to determine which mode will be excited first in such a device, the starting currents of competing modes should be calculated much more accurately than in gyrotrons with a rarer spectrum. In the present paper, an existing linear theory is generalized to take into account effects of magnetic field tapering, cavity profile, finite beam thickness, velocity spread and axially dependent beam coupling to the fields of competing modes. Starting currents are calculated for the operating and the most dangerous competing mode in a 140 GHz gyrotron, which is under development at Communication and Power Industries. Calculations show that the radial position of the electron beam plays a critical role in deciding which mode dominates the mode competition.

  16. Wide Field Imaging at 250 GHz

    OpenAIRE

    Carilli, C. L.; Bertoldi, F.; Bertarini, A.; Menten, K. M.; Kreysa, E.; Zylka, R.; Owen, F; Yun, M.

    2000-01-01

    Comment: 5 pages. 'Deep Millimeter Surveys: Implications for Galaxy Formation and Evolution,' eds. Lowenthal and Hughes, World Scientific. For higher quality figures see: http://www.aoc.nrao.edu/~ccarilli/ccarilli.shtml

  17. Human plasma DNP level after severe brain injury

    Institute of Scientific and Technical Information of China (English)

    GAO Yi-lu; XIN Hui-ning; FENG Yi; FAN Ji-wei

    2006-01-01

    Objective: To determine the relationship between DNP level after human severe brain injury and hyponatremia as well as isorrhea.Methods: The peripheral venous plasma as control was collected from 8 volunteers. The peripheral venous plasma from 14 severe brain injury patients were collected in the 1, 3, 7 days after injury. Radioimmunoassay was used to detect the DNP concentration. Meanwhile, daily plasma and urine electrolytes, osmotic pressure as well as 24 h liquid intake and output volume were detected.Results: The normal adult human plasma DNP level was 62. 46 pg/ml ± 27. 56 pg/ml. In the experimental group, the plasma DNP levels were higher from day 1 today 3 in 8 of the 14 patients than those in the control group (P1 =0.05, P3 =0.03). Negative fluid balance occurred in 8 patients and hyponatremia in 7 patients. The increase of plasma DNP level was significantly correlated with the development of a negative fluid balance (r=-0.69,P<0.01) and hyponatremia (x2 =4.38, P<0.05).Conclusions: The increase of plasma DNP level is accompanied by the enhancement of natriuretic and diuretic responses in severe brain-injured patients, which is associated with the development of a negative fluid balance and hyponatremia after brain injury.

  18. Development in Russia of high power gyrotrons for fusion

    International Nuclear Information System (INIS)

    Full text: Electron cyclotron systems of fusion installations are based on powerful millimetre wave sources - gyrotrons, which are capable to produce now microwave power up to 1 MW in very long (hundreds of seconds) pulses. The paper presents the latest achievements in development at IAP/GYCOM of MW power level gyrotrons for fusion installations. Among them are a new versions of 170 GHz gyrotron for ITER and multi-frequency (105-140 GHz) gyrotron for Asdex-Up. The gyrotrons are equipped with diamond CVD windows and depressed collectors. The most efforts were spent for development of ITER gyrotron. The tests are carried out at specially prepared test stand in Kurchatov Institute. The following gyrotron output parameters were demonstrated so far in many pulses: 1MW/30 sec and 0.64 MW/300 sec. Also a gyrotron with a higher power -1.5 MW was designed and tested in short pulses. The tests continue. In two tested long-pulse dual-frequency gyrotrons, power in the output Gaussian beam exceeding 0.9MW at 140GHz and 0.7MW at 105GHz was attained at specified 10-s pulse duration. The multi-frequency gyrotron should operate at least at four frequencies in the frequency range 105GHz-140 GHz. Two window concepts for the gyrotron are considered: Brewster window and two-disc adjustable window. Last years significant efforts were done by IAP/GYCOM in order to solve the whole scope of problems associated with the use of CVD diamond windows in gyrotrons: growing of discs, their cutting and polishing, and then high-temperature brazing and mounting to a tube. Two setups for growing diamond discs have been put into operation. The first discs grown at IAP have acceptable mechanical and electrical parameters. The IAP/GYCOM discs have been successfully brazed at near 800 deg. C temperature to metal constructions and tested with high-power gyrotrons. (author)

  19. A Study of the Perceptions of Doctor of Nursing (DNP) Program Administrators regarding the Integration of Acupuncture and Acupressure in DNP Curricula

    Science.gov (United States)

    Voight, Rebecca W.

    2012-01-01

    The purpose of this quantitative descriptive study was to explore the perceptions of DNP administrators regarding the extent acupuncture and acupressure are addressed in DNP curricula. Five research questions were addressed: 1. What are the perspectives of DNP program administrators regarding acupuncture and acupressure? 2. What are the…

  20. Recent achievements on tests of series gyrotrons for W7-X and planned extension at the KIT gyrotron test facility

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, M., E-mail: martin.schmid@kit.edu [Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Institute for Pulsed Power and Microwave Technology (IHM) (Germany); Choudhury, A. Roy; Dammertz, G. [Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Institute for Pulsed Power and Microwave Technology (IHM) (Germany); Erckmann, V. [Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Max-Planck-Institute for Plasmaphysics, Association EURATOM-IPP, Greifswald (Germany); Gantenbein, G.; Illy, S. [Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Institute for Pulsed Power and Microwave Technology (IHM) (Germany); Jelonnek, J. [Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Institute for Pulsed Power and Microwave Technology (IHM) (Germany); Institute of High Frequency Techniques and Electronics (IHE) (Germany); Kern, S. [Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Institute for Pulsed Power and Microwave Technology (IHM) (Germany); Legrand, F. [Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Thales Electron Devices, Vélicy (France); Rzesnicki, T.; Samartsev, A. [Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Institute for Pulsed Power and Microwave Technology (IHM) (Germany); Schlaich, A.; Thumm, M. [Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Institute for Pulsed Power and Microwave Technology (IHM) (Germany); Institute of High Frequency Techniques and Electronics (IHE) (Germany)

    2013-10-15

    Highlights: ► Solution found to suppress parasitic beam tunnel oscillations on high power gyrotrons. ► Electron beam sweeping technique to avoid plastic deformation on collector of high power gyrotrons. ► Ongoing investigations on limitations of gyrotron efficiency. ► Upgrade of 10 MW CW modulator for gyrotrons with multistage depressed collectors. -- Abstract: Parasitic beam tunnel oscillations have been hampering the series production of gyrotrons for W7-X. This problem has now been overcome thanks to the introduction of a specially corrugated beam tunnel. Two gyrotrons equipped with the new beam tunnel have fully passed the acceptance tests. Despite excellent power capability, the expected efficiency has not yet been achieved, possibly due to the presence of parasitic oscillations suspected to be dynamic after-cavity-oscillations (ACI's) or due to insufficient electron beam quality. Both theoretical and experimental investigations on these topics are ongoing. On previous W7-X gyrotrons collector fatigue has been observed, not (yet) leading to any failures so far. The plastic deformation occurring on the collector has now been eliminated due to the strict use (on all gyrotrons) of a sweeping method which combines the conventional 7 Hz solenoid sweeping technique with a 50 Hz transverse-field sweep system. Starting in 2013, the gyrotron test facility at KIT will be enhanced, chiefly with a new 10 MW DC modulator, capable of testing gyrotrons up to 4 MW CW output power with multi-stage-depressed collectors.

  1. Recent achievements on tests of series gyrotrons for W7-X and planned extension at the KIT gyrotron test facility

    International Nuclear Information System (INIS)

    Highlights: ► Solution found to suppress parasitic beam tunnel oscillations on high power gyrotrons. ► Electron beam sweeping technique to avoid plastic deformation on collector of high power gyrotrons. ► Ongoing investigations on limitations of gyrotron efficiency. ► Upgrade of 10 MW CW modulator for gyrotrons with multistage depressed collectors. -- Abstract: Parasitic beam tunnel oscillations have been hampering the series production of gyrotrons for W7-X. This problem has now been overcome thanks to the introduction of a specially corrugated beam tunnel. Two gyrotrons equipped with the new beam tunnel have fully passed the acceptance tests. Despite excellent power capability, the expected efficiency has not yet been achieved, possibly due to the presence of parasitic oscillations suspected to be dynamic after-cavity-oscillations (ACI's) or due to insufficient electron beam quality. Both theoretical and experimental investigations on these topics are ongoing. On previous W7-X gyrotrons collector fatigue has been observed, not (yet) leading to any failures so far. The plastic deformation occurring on the collector has now been eliminated due to the strict use (on all gyrotrons) of a sweeping method which combines the conventional 7 Hz solenoid sweeping technique with a 50 Hz transverse-field sweep system. Starting in 2013, the gyrotron test facility at KIT will be enhanced, chiefly with a new 10 MW DC modulator, capable of testing gyrotrons up to 4 MW CW output power with multi-stage-depressed collectors

  2. 100 GHz, 1 MW, CW gyrotron study program. Final report

    International Nuclear Information System (INIS)

    The results of a study program to investigate the feasibility of various approaches in designing a 100 GHz, 1 MW CW gyrotron are presented. A summary is given of the possible configurations for a high average power, high frequency gyrotron, including an historical survey of experimental results which are relevant to the various approaches. A set of basic scaling considerations which enable qualitative comparisons between particular gyrotron interaction circuits is presented. These calculations are important in understanding the role of various electron beam and circuit parameters in achieving a viable gyrotron design. Following these scaling exercises, a series of design calculations is presented for a possible approach in achieving 100 GHz, 1 MW CW. These calculations include analyses of the electron gun and interaction circuit parts of the gyrotron, and a general analysis of other aspects of a high average power, high frequency gyrotron. Scalability of important aspects of the design to other frequencies is also discussed, as well as key technology issues

  3. Development of high power long pulse gyrotron for ITER

    International Nuclear Information System (INIS)

    A development of 170GHz gyrotron has been carried out as a task of ITER/EDA, and remarkable progress was obtained. Critical issues on the gyrotron development; low efficiency, high heat load at the resonator, window problem, have been solved by breakthroughs; a depressed collector, 1MW single mode oscillation with a high order mode TE31,8, and development of the diamond window gyrotron, respectively. The prototype ITER gyrotron which integrated these technologies were fabricated and tested. Up to now, the power output of 0.45MW, 8sec has been obtained with a diamond window gyrotron. These results give a clear prospect of the 1MW/CW 170GHz gyrotron. (author)

  4. Gyrotron electromagnetic wiggler for a compact free electron laser

    International Nuclear Information System (INIS)

    We have demonstrated a novel, high power (≥1 MW), short wavelength (2 mm) gyrotron electromagnetic (GEM) wiggler for use in a compact free electron laser (FEL). The gyrotron consisted of an electron gun and resonator section followed by a special high Q cavity for storing the power created in the gyrotron resonator. The electromagnetic field stored in the high Q cavity would then be appropriate for use as a wiggler field in an infrared or visible FEL with a moderate energy (4 to 10 MeV) electron beam. The gyrotron experiment tested the practical limits due to ohmic loss, mode conversion, etc. on the strength of such a stored field. It also tested the effect of strong feedback from the high Q cavity back onto the gyrotron resonator. The proposed research utilized the technology of high power, high frequency gyrotrons developed at M.I.T. as part of the Department of Energy program on development of sources for plasma heating

  5. High harmonic terahertz confocal gyrotron with nonuniform electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Fu, Wenjie; Guan, Xiaotong; Yan, Yang [THz Research Center, School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu 610054 (China)

    2016-01-15

    The harmonic confocal gyrotron with nonuniform electron beam is proposed in this paper in order to develop compact and high power terahertz radiation source. A 0.56 THz third harmonic confocal gyrotron with a dual arc section nonuniform electron beam has been designed and investigated. The studies show that confocal cavity has extremely low mode density, and has great advantage to operate at high harmonic. Nonuniform electron beam is an approach to improve output power and interaction efficiency of confocal gyrotron. A dual arc beam magnetron injection gun for designed confocal gyrotron has been developed and presented in this paper.

  6. Theory and Modeling of High-Power Gyrotrons

    Energy Technology Data Exchange (ETDEWEB)

    Nusinovich, Gregory Semeon [Univ. of Maryland, College Park, MD (United States)

    2016-04-29

    This report summarized results of the work performed at the Institute for Research in Electronics and Applied Physics of the University of Maryland (College Park, MD) in the framework of the DOE Grant “Theory and Modeling of High-Power Gyrotrons”. The report covers the work performed in 2011-2014. The research work was performed in three directions: - possibilities of stable gyrotron operation in very high-order modes offering the output power exceeding 1 MW level in long-pulse/continuous-wave regimes, - effect of small imperfections in gyrotron fabrication and alignment on the gyrotron efficiency and operation, - some issues in physics of beam-wave interaction in gyrotrons.

  7. The Coppin State University Doctor of Nursing Practice (DNP) Program.

    Science.gov (United States)

    Tilghman, Joan S

    2015-01-01

    The Doctor of Nursing Practice (DNP) program development was identified as a pivotal part of the Coppin State University (CSU) Helene Fuld School of Nursing's' Strategic Plan. The program was launched as early as 2009 with plans to be implemented before 2015. The program was developed in response to the October 2004 endorsement of the American Association of Colleges of Nursing (AACN) position statement which recognizes the DNP as the appropriate credential for all advanced nursing practice roles by 2015. The Helene Fuld School of Nursing began its inaugural doctoral program in May 2015. The CSU DNP program will prepare graduates to address current and future practice issues. This program will prepare post baccalaureate graduates of nursing programs and post Master's advanced practice nurses to earn the DNP degree. The curriculum balances didactics, and clinical application in actual patient care facilities and health agencies relevant to course content. The DNP program fulfills CSU's goal to prepare graduates who distinguish themselves as leaders and service providers in critical and essential professions that offer life-long diverse employment, professional growth, and service opportunities. PMID:26665500

  8. Educating DNP students about critical appraisal and knowledge translation.

    Science.gov (United States)

    Moore, Elizabeth R; Watters, Richard

    2013-01-01

    Consumers expect that health care providers will use the best evidence when assisting them in making decisions about treatment options. Nurses at all educational levels report that they lack knowledge to critically appraise research studies and the skills to effectively implement evidence-based practice (EBP) in their clinical settings. Organizational culture and management support of innovation are critical factors in the adoption of EBP. Doctor of Nursing Practice (DNP) graduates can have a pivotal role in the transfer of knowledge to practice, yet critical appraisal and EBP competencies for DNP and Master of Science in Nursing (MSN) students have not been well differentiated in nursing curricula. Also students' attitudes toward EBP, self-efficacy beliefs, utilization, and knowledge gaps are rarely evaluated before courses are designed. This article reports on the development of a DNP-level EBP course to help students evaluate and apply research findings to clinical practice.

  9. 28 GHz Gyrotron ECRH Upgrade for LDX

    Science.gov (United States)

    Michael, P. C.; Woskov, P. P.; Ellsworth, J. L.; Kesner, J.; Garnier, D. T.; Mauel, M. E.; Ellis, R. F.

    2009-11-01

    A 10 kW, CW, 28 GHz gyrotron is being implemented on LDX to increase the plasma density and to more fully explore the potential of high beta plasma stability in a dipole magnetic configuration. Higher density increases the heating of ions by thermal equilibration and allows for improved wave propagation in planned ICRF experiments. This represents over a 50% increase in the 17 kW ECRH from sources at 2.45, 6.4, and 10.5 GHz. The higher frequency will also make possible access to plasma densities of up to 10^13 cm-3. The 1 Tesla resonances are located above and below the floating coil near the dipole axial region. The gyrotron beam will be transmitted in TE01 mode in 32.5 mm diameter guide using one 90 bend and a short Tesla resonance region. A layout of the planned system will be presented.

  10. Improved Collectors for High Power Gyrotrons

    Energy Technology Data Exchange (ETDEWEB)

    Ives, R. Lawrence; Singh, Amarjit; Read, Michael; Borchard, Phillipp; Neilson, Jeff

    2009-05-20

    High power gyrotrons are used for electron cyclotron heating, current drive and parasitic mode suppression in tokamaks for fusion energy research. These devices are crucial for successful operation of many research programs around the world, including the ITER program currently being constructed in France. Recent gyrotron failures resulted from cyclic fatigue of the copper material used to fabricated the collectors. The techniques used to collect the spent beam power is common in many gyrotrons produced around the world. There is serious concern that these tubes may also be at risk from cyclic fatigue. This program addresses the cause of the collector failure. The Phase I program successfully demonstrated feasibility of a mode of operation that eliminates the cyclic operation that caused the failure. It also demonstrated that new material can provide increased lifetime under cyclic operation that could increase the lifetime by more than on order of magnitude. The Phase II program will complete that research and develop a collector that eliminates the fatigue failures. Such a design would find application around the world.

  11. Design of Single disc RF window for High Power Gyrotron

    International Nuclear Information System (INIS)

    In this paper investigates the design of water edge cooled single-disc CVD-diamond window for 120 GHz, 1MW gyrotron. The design of RF window for 120 GHz, 1MW gyrotron has been carried out using the CST microwave studio. In 120 GHz gyrotron single disc of diameter 90 mm and thickness 2.0 mm CVD diamond window has been used in the simulation. The return loss (S11) and transmission loss (S21) of the 120 GHz gyrotron window have been found - 40.0 dB and -0.02 dB respectively. Thermal analysis of single disc rf window has also been carried out using ANSYS software for high power 120 GHz gyrotron. The temperature range on the disc surface has been found to be 100 °C - 300 ° C.

  12. Russian roulette with unlicensed fat-burner drug 2,4-dinitrophenol (DNP): evidence from a multidisciplinary study of the internet, bodybuilding supplements and DNP users.

    OpenAIRE

    Petroczi, Andrea; Ocampo, Jorge A. Vela; Shah, Iltaf; Jenkinson, Carl; New, Rachael; James, Ricky A.; Taylor, Glenn; Naughton, Declan P.

    2015-01-01

    Background 2,4-Dinitrophenol (DNP) poses serious health-risks to humans. The aims of this three-stage multidisciplinary project were, for the first time, to assess the risks to the general public from fraudulent sale of or adulteration/contamination with DNP; and to investigate motives, reasons and risk-management among DNP-user bodybuilders and avid exercisers. Methods Using multiple search-engines and guidance for Internet research, online retailers and bodybuilding forums/blogs were system...

  13. Study on the aerobic biodegradability and degradation kinetics of 3-NP; 2,4-DNP and 2,6-DNP

    International Nuclear Information System (INIS)

    Highlights: ► We assessed the biodegradability of three nitrophenols using four methods. ► We simulated the degradation kinetics model and estimated relevant parameters. ► We compared the kinetics performances of solo substrates and co-substrates. - Abstract: Four biodegradability tests (BOD5/COD ratio, production of carbon dioxide, relative oxygen uptake rate and relative enzymatic activity) were used to determine the aerobic biodegradability of 3-nitrophenol (3-NP), 2,4-dinitrophenol (2,4-DNP) and 2,6-dinitrophenol (2,6-DNP). Furthermore, biodegradation kinetics of the compounds was investigated in sequencing batch reactors both in the presence of glucose (co-substrate) and with nitrophenol as the sole carbon source. Among the three tested compounds, 3-NP showed the best biodegradability while 2,6-DNP was the most difficult to be biodegraded. The Haldane equation was applied to the kinetic test data of the nitrophenols. The kinetic constants are as follows: the maximum specific degradation rate (Kmax), the saturation constants (KS) and the inhibition constants (KI) were in the range of 0.005–2.98 mg (mgSS d)−1, 1.5–51.9 mg L−1 and 1.8–95.8 mg L−1, respectively. The presence of glucose enhanced the degradation of the nitrophenols at low glucose concentrations. The degradation of 3-NP was found to be accelerated with the increasing of glucose concentrations from 0 to 660 mg L−1. At high (1320–2000 mg L−1) glucose concentrations, the degradation rate of 3-NP was reduced and the Kmax of 3-NP was even lower than the value obtained in the absence of glucose, suggesting that high concentrations of co-substrate could inhibit 3-NP biodegradation. At 2,4-DNP concentration of 30 mg L−1, the Kmax of 2,4-DNP with glucose as co-substrate was about 30 times the value with 2,4-DNP as sole substrate. 2,6-DNP preformed high toxicity in the case of sole carbon source degradation and the kinetic data was hardly obtained.

  14. Study on the aerobic biodegradability and degradation kinetics of 3-NP; 2,4-DNP and 2,6-DNP

    Energy Technology Data Exchange (ETDEWEB)

    She, Zonglian; Xie, Tian; Zhu, Yingjie; Li, Leilei; Tang, Gaifeng [Key Laboratory of Marine Environmental Science and Ecology, Ministry of Education, College of Environmental Science and Engineering, Ocean University of China, Qingdao 266100 (China); Huang, Jian, E-mail: jianhuang666@hotmail.com [Department of Environmental Ecology, College of Marine Life Sciences, Ocean University of China, Qingdao 266003 (China)

    2012-11-30

    Highlights: Black-Right-Pointing-Pointer We assessed the biodegradability of three nitrophenols using four methods. Black-Right-Pointing-Pointer We simulated the degradation kinetics model and estimated relevant parameters. Black-Right-Pointing-Pointer We compared the kinetics performances of solo substrates and co-substrates. - Abstract: Four biodegradability tests (BOD{sub 5}/COD ratio, production of carbon dioxide, relative oxygen uptake rate and relative enzymatic activity) were used to determine the aerobic biodegradability of 3-nitrophenol (3-NP), 2,4-dinitrophenol (2,4-DNP) and 2,6-dinitrophenol (2,6-DNP). Furthermore, biodegradation kinetics of the compounds was investigated in sequencing batch reactors both in the presence of glucose (co-substrate) and with nitrophenol as the sole carbon source. Among the three tested compounds, 3-NP showed the best biodegradability while 2,6-DNP was the most difficult to be biodegraded. The Haldane equation was applied to the kinetic test data of the nitrophenols. The kinetic constants are as follows: the maximum specific degradation rate (K{sub max}), the saturation constants (K{sub S}) and the inhibition constants (K{sub I}) were in the range of 0.005-2.98 mg (mgSS d){sup -1}, 1.5-51.9 mg L{sup -1} and 1.8-95.8 mg L{sup -1}, respectively. The presence of glucose enhanced the degradation of the nitrophenols at low glucose concentrations. The degradation of 3-NP was found to be accelerated with the increasing of glucose concentrations from 0 to 660 mg L{sup -1}. At high (1320-2000 mg L{sup -1}) glucose concentrations, the degradation rate of 3-NP was reduced and the K{sub max} of 3-NP was even lower than the value obtained in the absence of glucose, suggesting that high concentrations of co-substrate could inhibit 3-NP biodegradation. At 2,4-DNP concentration of 30 mg L{sup -1}, the K{sub max} of 2,4-DNP with glucose as co-substrate was about 30 times the value with 2,4-DNP as sole substrate. 2,6-DNP preformed high

  15. Velocity diagnostics of electron beams within a 140 GHz gyrotron

    International Nuclear Information System (INIS)

    Experimental measurements of the average axial velocity vparallel of the electron beam within the M.I.T. 140 GHz MW gyrotron have been performed. The method involves the simultaneous measurement of the radial electrostatic potential of the electron beam Vp and the beam current Ib. Vp is measured through the use of a capacitive probe installed near or within the gyrotron cavity, while Ib is measured with a previously installed Rogowski coil. Three capacitive probes have been designed and built, and two have operated within the gyrotron. The probe results are repeatable and consistent with theory. The measurements of vparallel and calculations of the corresponding transverse to longitudinal beam velocity ratio α = vperpendicular/vparallel at the cavity have been made at various gyrotron operation parameters. These measurements will provide insight into the causes of discrepancies between theoretical rf interaction efficiencies and experimental efficiencies obtained in experiments with the M.I.T. 140 GHz MW gyrotron. The expected values of vparallel and α are determined through the use of a computer code entitled EGUN. EGUN is used to model the cathode and anode regions of the gyrotron and it computes the trajectories and velocities of the electrons within the gyrotron. There is good correlation between the expected and measured values of α at low α, with the expected values from EGUN often falling within the standard errors of the measured values. 10 refs., 29 figs., 2 tabs

  16. 110 GHz, 1 MW Gyrotron Design Upgrades

    Science.gov (United States)

    Cauffman, Steve; Felch, Kevin; Borchard, Philipp; Cahalan, Pat; Chu, Sam; Dubrule, Craig

    1999-11-01

    Communications and Power Industries has incorporated a number of design changes into its most recent series of 110 GHz 1 MW gyrotrons, for use in ECH and ECCD experiments on the DIII-D tokamak. Two development gyrotrons previously installed at DIII-D used a modulating-anode electron gun design and output windows consisting of double-disk face-cooled sapphire on one system and an edge-cooled CVD diamond disk on the other. Three new systems presently in fabrication and test employ (a) a single-anode electron gun to avoid excitation of spurious modes during turn-on and turn-off and to simplify power supply requirements, (b) a modified TE_22,6 cavity to reduce competition from neighboring modes, (c) a two inch aperture edge-cooled CVD diamond window to allow transmission of a 1 MW Gaussian output beam, (d) a superconducting magnet system with a cryo-cooler to reduce liquid helium consumption, and (e) a number of internal and external plumbing simplifications to make cooling system connections more straightforward. Initial test results, if available, will be presented.

  17. 28 GHz Gyrotron ECRH on LDX

    Science.gov (United States)

    Woskov, P. P.; Kesner, J.; Michael, P. C.; Garnier, D. T.; Mauel, M. E.

    2010-12-01

    A 10 kW, CW, 28 GHz gyrotron has been implemented on LDX to increase the plasma density and to more fully explore the potential of high beta plasma stability in a dipole magnetic configuration. This added power represents about a 60% increase in ECRH to a new total of 26.9 kW with sources at 2.45, 6.4, and 10.5 GHz. The 1 Tesla resonances in LDX form small rings encompassing the entire plasma cross-section above and below the floating coil (F-coil) near the dipole axial region. A 32.5 mm diameter TE01 waveguide with a partial Vlasov step cut launches a diverging beam from above the F-coil that depends on internal wall reflections for plasma coupling. Initial gyrotron only plasmas exhibit steep natural profiles with fewer hot electrons than with the other sources. The background scattered radiation suggests that only about half the power is being absorbed with the present launcher.

  18. High power millimeter and submillimeter wave lasers and gyrotrons

    Science.gov (United States)

    Temkin, R. J.; Cohn, D. R.; Danly, B. G.; Kreischer, K. E.; Woskoboinikow, P.

    1985-10-01

    High power sources of coherent radiation in the millimeter and submillimeter wavelength range are useful in a number of applications, including plasma heating, plasma diagnostics, radar and communications. Two of the most important sources in this wavelength range are the optically pumped laser and the gyrotron. Major recent advances in both laser and gyrotron research are described. Possible techniques for improving the efficiency and operating characteristics of these devices are also reviewed.

  19. Technical developments at the KIT gyrotron test facility

    International Nuclear Information System (INIS)

    Parasitic beam tunnel oscillations have been discovered on some of the series production gyrotrons for W7-X and also on the coaxial pre-prototype gyrotron for ITER. Solutions to remedy these problems have resulted in a modified beam tunnel design, technologically close to the existing beam tunnel. The new design has successfully been tested on both the coaxial and also the f-step-tunable gyrotrons and has subsequently been implemented on one of the W7-X series-production-tubes presently undergoing factory acceptance tests in Karlsruhe. The ECRH test loads at KIT are operated under normal atmospheric conditions. Several loads have eventually failed in 1 MW long pulse experiments and KIT has therefore started to design its own loads. The first KIT-load is based on a fixed conical mirror and an aluminum cylinder coated with a lossy material for increased absorption. The new load has so far successfully been used during the acceptance tests of two 1-MW CW gyrotrons. Nevertheless a new load based on pure (uncoated) stainless steel absorbers is being developed as a backup solution for the ongoing high priority gyrotron testing. A superconducting magnet capable of rapid field changes between 4.15 and 5.67 T for frequency step-tunable gyrotrons has been procured, has demonstrated a (static) field of 7.2 T and its capability of rapid field-changes.

  20. A simple quantum-electronic approach to the Gyrotron and its application to the solid-state gyrotron

    Science.gov (United States)

    Ho, P.-T.; Granatstein, V. L.

    1986-01-01

    A simple, unifying theory of the gyrotron is presented. It is of the Lamb type. Within its framework, important results from different approaches can be easily obtained. As an application, gyrotron action in InSb is reexamined, and coherent emission at 10 to the 12th Hz appears possible with an output power of about 0.5 mW/sq mm of the device.

  1. Effect of dendroaspis natriuretic peptide (DNP) on L-type calcium channel current and its pathway.

    Science.gov (United States)

    Zhang, Shu-Ying; Cai, Zheng-Xu; Li, Ping; Cai, Chun-Yu; Qu, Cheng-Long; Guo, Hui-Shu

    2010-09-24

    Dendroaspis natriuretic peptide (DNP), a newly-described natriuretic peptide, relaxes gastrointestinal smooth muscle. L-type calcium channel currents play an important role in regulating smooth muscle contraction. The effect of DNP on L-type calcium channel currents in gastrointestinal tract is still unclear. This study was designed to investigate the effect of DNP on barium current (I(Ba)) through the L-type calcium channel in gastric antral myocytes of guinea pigs and cGMP-pathway mechanism. The whole-cell patch-clamp technique was used to record L-type calcium channel currents. The content of cGMP in guinea pig gastric antral smooth muscle and perfusion solution was measured using radioimmunoassay. DNP markedly enhanced cGMP levels in gastric antral smooth muscle tissue and in perfusion medium. DNP concentration-dependently inhibited I(Ba) in freshly isolated guinea pig gastric antral circular smooth muscle cells (SMCs) of guinea pigs. DNP-induced inhibition of I(Ba) was partially blocked by LY83583, an inhibitor of guanylate cyclase. KT5823, a cGMP-dependent protein kinase (PKG) inhibitor, almost completely blocked DNP-induced inhibition of I(Ba). However, DNP-induced inhibition of I(Ba) was potentiated by zaprinast, an inhibitor of cGMP-sensitive phosphodiesterase. Taken together, DNP inhibits L-type calcium channel currents via pGC-cGMP-PKG-dependent signal pathway in gastric antral myocytes of guinea pigs. PMID:20594955

  2. Gyrotrons for magnetic fusion applications at 110 GHz and 170 GHz

    Directory of Open Access Journals (Sweden)

    Cahalan P.

    2012-09-01

    Full Text Available Two megawatt-class gyrotrons at frequencies of 110 GHz and 170 GHz have recently been fabricated at CPI. The 110 GHz gyrotron is designed to produce 1.2 MW of output power for 10-second pulses, and will be used for electron cyclotron heating and current drive on the DIII-D tokamak at General Atomics. This gyrotron has completed factory testing and has been delivered to General Atomics for installation and additional testing. The 170 GHz gyrotron, though specified as a 500 kW CW system, has been designed with the goal of generating up to 1 MW CW. Oak Ridge National Laboratory will use this gyrotron in ITER ECH transmission line testing. This gyrotron has been fabricated and is awaiting factory testing, Design features of each gyrotron are described, and test data for the 110 GHz gyrotron are presented.

  3. Herramientas DNP3 pentesting para redes de infraestructura critica

    Directory of Open Access Journals (Sweden)

    M. Sánchez

    2016-07-01

    Full Text Available Este artículo presenta un conjunto de herramientas de software que son capaces de realizar actividades Pentesting en la infraestructura crítica del sector eléctrico mediante el protocolo DNP3. Las herramientas son capaces de comprobar la capacidad de los controles de seguridad cibernética en el interior del perímetro de la red para evitar cualquier comando sensible falsificado pueda llegar a cualquier controlador de subestación

  4. Membrane localization and topology of the DnpA protein control fluoroquinolone tolerance in Pseudomonas aeruginosa.

    Science.gov (United States)

    Liebens, Veerle; Frangipani, Emanuela; Van der Leyden, Annelies; Fauvart, Maarten; Visca, Paolo; Michiels, Jan

    2016-09-01

    DnpA, a putative de-N-acetylase of the PIG-L superfamily, is required for antibiotic tolerance in Pseudomonas aeruginosa Exactly how dnpA (gene locus PA5002) directs the formation of antibiotic-tolerant persister cells is currently unknown. Previous research provided evidence for a role in surface-associated process(es), possibly in lipopolysaccharide biosynthesis. In silico sequence analysis of DnpA predicts a single transmembrane domain and Nin/Cout orientation of DnpA. In contrast, we here show that DnpA is an integral inner membrane protein containing two transmembrane domains, with the major C-terminal part located at the cytoplasmic face. Correct insertion into the inner membrane is necessary for DnpA to promote fluoroquinolone tolerance. The membrane localization of DnpA further supports its role in cell envelope-associated process(es). In addition to shedding light on the biological role of DnpA, this study highlights the risks of overreliance on the predictive value of bioinformatics tools and the importance of rigorous experimental validation of in silico predictions. PMID:27481702

  5. Building skills in organizational and systems changes: a DNP-FNP clinical curriculum.

    Science.gov (United States)

    Hoyle, Christine; Johnson, Gail

    2015-04-13

    DNP-prepared nurse practitioner leaders play a pivotal role in organizational change and quality improvement consistent with the IHI Triple Aim: improving quality of care, health of populations, and reducing cost. A DNP-FNP curriculum is described, designed to build students' leadership competencies for systems change in healthcare settings.

  6. Cutaneous drug toxicity from 2,4-dinitrophenol (DNP): Case report and histological description.

    Science.gov (United States)

    Le, Patricia; Wood, Benjamin; Kumarasinghe, Sujith Prasad

    2015-11-01

    The use of 2,4-dinitrophenol (DNP) has regained popularity as a weight loss aid in the last two decades due to increased marketing to bodybuilders and the increasing availability of this banned substance via the Internet. 2,4-DNP is a drug of narrow therapeutic index and toxicity results in hyperthermia, diaphoresis, tachycardia, tachypnoea and possible cardiac arrest and death. Skin toxicity from 2,4-DNP has not been reported since the 1930s. We report a case of a 21-year-old bodybuilding enthusiast who presented with a toxic exanthem after taking 2,4-DNP, and describe the first skin biopsy findings in a case of 2,4-DNP toxicity.

  7. Cutaneous drug toxicity from 2,4-dinitrophenol (DNP): Case report and histological description.

    Science.gov (United States)

    Le, Patricia; Wood, Benjamin; Kumarasinghe, Sujith Prasad

    2015-11-01

    The use of 2,4-dinitrophenol (DNP) has regained popularity as a weight loss aid in the last two decades due to increased marketing to bodybuilders and the increasing availability of this banned substance via the Internet. 2,4-DNP is a drug of narrow therapeutic index and toxicity results in hyperthermia, diaphoresis, tachycardia, tachypnoea and possible cardiac arrest and death. Skin toxicity from 2,4-DNP has not been reported since the 1930s. We report a case of a 21-year-old bodybuilding enthusiast who presented with a toxic exanthem after taking 2,4-DNP, and describe the first skin biopsy findings in a case of 2,4-DNP toxicity. PMID:25367505

  8. Start current analysis of a 140 GHz CPI gyrotron

    Science.gov (United States)

    Yeddulla, M.; Nusinovich, G. S.; Antonsen, T. M.

    2003-12-01

    In a gyrotron, it is difficult to accurately predict in advance where the resonant interaction between the electrons and outgoing radiation stops. For accurately calculating the start currents for the interacting modes, the exit coordinate has to be fixed where the resonant interaction stops. This paper discusses the difficulty in fixing the exit coordinates for studying start currents in an overmoded gyrotron. Start currents are studied for the operating and the most dangerous parasitic mode of a 140 GHz gyrotron being developed by Communication and Power Industries (CPI). Calculations show that the start currents vary over considerably large values with varying exit coordinates that can cause difficulties in predicting which mode dominates the mode competition.

  9. Designing A Mode Converter For Use With A Gyrotron

    Science.gov (United States)

    Hoppe, Daniel J.

    1995-01-01

    Report describes process of designing corrugated, circular-cross-section length of waveguide converting input electromagnetic radiation at frequency of 34.5 GHz in TM(11) mode to output radiation in HE(11) mode. TM(11)-mode input radiation supplied by gyrotron generating continuous-wave power of 200 kW at 34.5 GHz in TE(01) mode followed by TE(01)-to-TM(11) mode converter. Together, gyrotron and mode converters constitute prototype high-power transmitter for long-distance free-space communication.

  10. Phase locking and bandwidth in a gyrotron oscillator

    Science.gov (United States)

    Latham, P. E.; Granatstein, V. L.; Carmel, Y.

    1993-06-01

    For imaging radar and for satellite and space communication (e.g. NASA's deep space network), it is important that the bandwidth be as large as possible. Here we derive a formalism for computing the phase locking bandwidth that can be achieved in a gyrotron oscillator while varying the beam voltage. As an example, a second harmonic TE02/03 gyrotron is considered. For this device, the effective bandwidth can be increased by a factor of about 3 compared with the fixed voltage case by allowing the beam voltage to change together with the input locking signal.

  11. Oscillating virtual cathode, large-orbit gyrotron and driver

    Energy Technology Data Exchange (ETDEWEB)

    VanHaaften, F.W.; Hoeberling, R.F.; Fazio, M.V.

    1986-01-01

    Studies using an oscillating virtual cathode (vircator) and a large-orbit gyrotron to generate microwave levels of several hundred megawatts are being conducted at the Los Alamos National Laboratory (LANL). A pulse level of approx.1 MV, with length approaching 1 ..mu..s at a repetition rate of a few hertz, is anticipated for extension of these studies from the present single-shot mode with 100-ns pulse width. The increased pulse width is needed to test longer pulse length microwave sources. Pulse forming network (PFN), transformer-coupled drivers have been studied and are part of the subject of this paper. The large-orbit gyrotron is discussed here.

  12. Suppression of parasitic space-charge oscillations in a gyrotron

    Science.gov (United States)

    Louksha, O. I.; Piosczyk, B.; Sominski, G. G.; Thumm, M.; Samsonov, D. B.

    2006-10-01

    We study the influence of nonuniform electric and magnetic fields in the helical-beam compression region on the low-frequency parasitic space-charge oscillations for a moderate-power (˜ 100 kW) 4-mm gyrotron. Suppression of the oscillations is achieved by optimization of both the cathode-unit geometry in the magnetron-injector gun and the magnetic-field distribution in the region near the cavity input. The obtained data are evidence of possible effective operation of the gyrotron at elevated pitch-factor values α > 1.5 even for emitters with no highest emission uniformity (δje ≈ 30%).

  13. Correlation of the EPR properties of perchlorotriphenylmethyl radicals and their efficiency as DNP polarizers.

    Science.gov (United States)

    Banerjee, Debamalya; Paniagua, Juan Carlos; Mugnaini, Veronica; Veciana, Jaume; Feintuch, Akiva; Pons, Miquel; Goldfarb, Daniella

    2011-11-01

    Water soluble perchlorinated trityl (PTM) radicals were found to be effective 95 GHz DNP (dynamic nuclear polarization) polarizers in ex situ (dissolution) (13)C DNP (Gabellieri et al., Angew Chem., Int. Ed. 2010, 49, 3360). The degree of the nuclear polarization obtained was reported to be dependent on the position of the chlorine substituents on the trityl skeleton. In addition, on the basis of the DNP frequency sweeps it was suggested that the (13)C NMR signal enhancement is mediated by the Cl nuclei. To understand the DNP mechanism of the PTM radicals we have explored the 95 GHz EPR characteristics of these radicals that are relevant to their performance as DNP polarizers. The EPR spectra of the radicals revealed axially symmetric g-tensors. A comparison of the spectra with the (13)C DNP frequency sweeps showed that although the solid effect mechanism is operational the DNP frequency sweeps reveal some extra width suggesting that contributions from EPR forbidden transitions involving (35,37)Cl nuclear flips are likely. This was substantiated experimentally by ELDOR (electron-electron double resonance) detected NMR measurements, which map the EPR forbidden transitions, and ELDOR experiments that follow the depolarization of the electron spin upon irradiation of the forbidden EPR transitions. DFT (density functional theory) calculations helped to assign the observed transitions and provided the relevant spin Hamiltonian parameters. These results show that the (35,37)Cl hyperfine and nuclear quadrupolar interactions cause a considerable nuclear state mixing at 95 GHz thus facilitating the polarization of the Cl nuclei upon microwave irradiation. Overlap of Cl nuclear frequencies and the (13)C Larmor frequency further facilitates the polarization of the (13)C nuclei by spin diffusion. Calculation of the (13)C DNP frequency sweep based on the Cl nuclear polarization showed that it does lead to an increase in the width of the spectra, improving the agreement with the

  14. DNp73 improves generation efficiency of human induced pluripotent stem cells

    Directory of Open Access Journals (Sweden)

    Lin Yi

    2012-03-01

    Full Text Available Abstract Background Recent studies have found that p53 and its' associated cell cycle pathways are major inhibitors of human induced pluripotent stem (iPS cell generation. In the same family as p53 is p73, which shares sequence similarities with p53. However, p73 also has distinct properties of its own, such as two alternative promoters to express transactivation of p73 (TAp73 and N terminal deleted p73 (DNp73. Functionally, TAp73 acts similarly to p53 in tumor suppression. However, DNp73, on the other hand acts as an oncogene to suppress p53 and p73 induced apoptosis. Therefore, how can p73 have opposing roles in human iPS cell generation? Results Transcription factors, Oct4, Sox2, Klf4 and cMyc (4TF, Yamanaka factors are used as basal conditions to generate iPS cells. In addition, the factor of DNp73(actually alpha splicing DNp73, DNp73α is used to generate iPS cells. The experiment found that the addition of DNp73 gene increases human iPS cell generation efficiency by 12.6 folds in comparison to human fibroblast cells transduced with only the basal conditions. Also, iPS cells generated with DNp73 expression are more resistant to in vitro and in vivo differentiation. Conclusions This study found DNp73, a family member of p53, is also involved in the human iPS cell generation. Specifically, that the involvement of DNp73 generates iPS cells that are more resistant to in vitro and in vivo differentiation. Therefore, this data may prove to be useful in future developmental studies and cancer researches.

  15. Active heater control and regulation for the Varian VGT-8011 gyrotron

    International Nuclear Information System (INIS)

    The Varian VGT-8011 gyrotron is currently being used in the new 110 GHz 2 MW ECH system installed on D3-D. This new ECH system augments the 60 GHz system which uses Varian VA-8060 gyrotrons. The new 110 GHz system will be used for ECH experiments on D3-D with a pulse width capability of 10 sec. In order to maintain a constant RF outpower level during long pulse operation, active filament-heater control and regulation is required to maintain a constant cathode current. On past D3-D experiments involving the use of Varian VA-8060 gyrotrons for ECH power, significant gyrotron heater-emission depletion was experienced for pulse widths > 300 msec. This decline in heater-emission directly results in gyrotron-cathode current droop. Since RF power from gyrotrons decreases as cathode current decreases, it is necessary to maintain a constant cathode current level during gyrotron pulses for efficient gyrotron operation. Therefore, it was determined that a filament-heater control system should be developed for the Varian VGT-8011 gyrotron which will include cathode-current feed-back. This paper discusses the mechanisms used to regulate gyrotron filament-heater voltage by using cathode-current feed-back. 1 fig

  16. Communication Test for ‘MatrikonOPC Server for SCADA DNP 3’ with RTDS

    DEFF Research Database (Denmark)

    Wu, Qiuwei; Cha, Seung-Tae; Saleem, Arshad;

    2010-01-01

    The purpose of the communication test for ‘MatrikonOPC server for SCADA DNP 3’ with RTDS is to verify the data exchange between the ‘MatrikonOPC server for SCADA DNP 3’ and the RTDS using the DNP 3 protocol.The communication test is part of the work for the ‘Wind in Øresund’ project. The objective...... of the ‘Wind in Øresund’ project is to build a demonstration and education system of power system operation and control with a RTDS and a SCADA system....

  17. Research on advanced high power gyrotrons at FZK

    International Nuclear Information System (INIS)

    The experimental 170 GHz coaxial cavity gyrotron for ITER has been assembled and installed in the SC magnet. The operation started in May 2004 with performing the alignment and conditioning of the tube. The main goal of the experiments is to verify the design of components for a 2 MW, CW industrial prototype

  18. Implementation of DNP3.0 in the EMCC System of Jinan Steel%DNP3.0在济钢EMCC系统中的实现

    Institute of Scientific and Technical Information of China (English)

    田坤

    2014-01-01

    The basic structure and function of DNP3.0 were mainly introduced. The specific method for implementation of DNP protocol in MOX was given taking the energy management and control center of Jinan Steel as an example, to achieve the “four remote”function through the protocol. Operation result has showed that DNP3.0 protocol has high communication efficiency and reliability.%主要介绍DNP3.0的基本结构和功能,结合济钢能源管控中心的实例,给出了DNP协议在MOX中的具体实现方法,通过该协议系统实现了“四遥”功能。现场运行结果显示,DNP3.0协议具有较高的通信效率和通信可靠性。

  19. Development of 100 GHz band high power gyrotron for fusion experimental reactor

    International Nuclear Information System (INIS)

    In JAERI, 1MW gyrotrons of 170GHz and 110GHz are under development for ITER (International Thermonuclear Experimental Reactor) and JT-60U, respectively. Both gyrotrons have a depressed collector for an efficiency improvement and a low loss synthetic diamond window that enables Gaussian beam output over 1MW. Three 110GHz gyrotrons are used on an electron cyclotron heating and current drive(ECH/ECCD) system on JT-60U, in which the output power of ∼0.8MW/3sec was generated from each gyrotron. As for 170GHz, output power of 1.2MW with electron beam of 85kV/49A was obtained on a short pulse gyrotron. The efficiency of ∼57% was attained at 1.1MW with the depressed collector. Based on these results, the 1MW 170GHz gyrotron for long pulse operation was fabricated. (author)

  20. Simplified THz Instrumentation for High-Field DNP-NMR Spectroscopy

    OpenAIRE

    Maly, Thorsten; Sirigiri, Jagadishwar R.

    2012-01-01

    We present an alternate simplified concept to irradiate a nuclear magnetic resonance sample with terahertz (THz) radiation for dynamic nuclear polarization (DNP) experiments using the TE01 circular waveguide mode for transmission of the THz power and the illumination of the DNP sample by either the TE01 or TE11 mode. Using finite element method and 3D electromagnetic simulations we demonstrate that the average value of the transverse magnetic field induced by the THz radiation and responsible...

  1. A novel vacuum window for megawatt gyrotrons

    Science.gov (United States)

    Haldeman, George Stephenson

    2001-08-01

    This thesis describes a new microwave output window for megawatt power level, 110 GHz gyrotrons. The window uses two spherically polished sapphire elements separated by a nearly uniform gap of about 1 mm. Pressurized, microwave transparent coolant flows through this gap and across the transmitting aperture, removing absorbed energy at the element face. The design differs from previous face- cooled windows because the sapphire elements have a modestly curved dome, rather than flat shape. This curved shape increases the element's capability to withstand coolant pressures without significantly increasing stresses from differential heating. Consequently, window power can be increased either through enhanced, high pressure cooling or by using thinner elements with reduced microwave absorption. A model was developed to predict window power capability as a function of design geometry. This model predicted an increase from 0.5 to 2.1 MW when flat elements were changed to curved. Both designs used full size, 100mm clear apertures, but the curved elements with 214 mm curvature radii were 1.3 rather than 1.75 mm thick. The model was also used to design a half size prototype experiment. This 50 mm clear aperture system used 60 mm OD x 0.47 mm thick x 107 mm surface radius elements. An initial piece was fabricated and statically tested to a pressure of 1.1 MPa well above the 0.5 MPa analytically predicted to be required for megawatt operation. The complete window structure was then fabricated, including instrumentation to simulate microwave heating and to measure induced temperatures and strains. Test results demonstrated an equivalent continuous Gaussian beam power capability of 700 kW using a coolant flow of 1.1 lps. Scaling from this measurement, fall size boiling limited power is expected to be 1.1 MW for a Gaussian microwave intensity profile, or 2.3 MW for a shaped profile typical of previous flat, face-cooled designs. (Copies available exclusively from MIT Libraries, Rm

  2. Recent Tests on 117.5 GHz and 170 GHz Gyrotrons

    Directory of Open Access Journals (Sweden)

    Felch K.

    2015-01-01

    Full Text Available Two megawatt-class gyrotrons at frequencies of 117.5 GHz and 170 GHz have recently been fabricated and tested at CPI. The 117.5 GHz gyrotron was designed to produce up to 1.8 MW for 10-second pulses, and will be used for electron cyclotron heating and current drive on the DIII-D tokamak at General Atomics. The 170 GHz gyrotron is specified as a 500 kW CW system, but has been designed with the goal of generating up to 1 MW CW. Oak Ridge National Laboratory will use the gyrotron in ITER ECH transmission line testing.

  3. Installation and operation of the 400 kW 140 GHZ gyrotron on the MTX experiment

    International Nuclear Information System (INIS)

    This paper describes the installation and operation of the 400 kW 140 GHz gyrotron used for plasma heating on the Microwave Tokamak Experiment (MTX) at Lawrence Livermore National Laboratory (LLNL). The Varian VGT-8140 gyrotron has operated at a power level of 400 kW for 100 ms in conjunction with MTX plasma shots. The gyrotron system is comprised of a high voltage (- 80 kV) modulated power supply, a multistation CAMAC computer control, a 5-tesla superconducting magnet, a series of conventional copper magnets, a circulating fluorinert (FC75) window cooling system, a circulating oil cooling system, a water cooling system, and microwave frequency and power diagnostics. Additionally, a Vlasov launcher is used to convert the gyrotron TE 15,2 mode to a Gaussian beam. Two versions of the Vlasov launcher have been used on the gyrotron, one version designed by LLNL and one version designed by the Japan Atomic Energy Research Institute (JAERI). The Varian VGT-8140 gyrotron has been installed on the MTX tokamak experiment to provide electron cyclotron resonant heating (ECRH) of the tokamak plasma. The gyrotron has been operated with the tokamak for periods as long as 100 ms at power levels of 400 kW. he gyrotron will also be used as the RF driver for the intense microwave prototype (IMP) wiggler associated with the electron test accelerator (ETA). In this configuration, the IMP wiggler will produce multigigawatt, 140 GHz, 50-ns pulses at a 5-kHz repetition rate. The plasma heating efficiency of the long RF pulse from the gyrotron can then be compared with the higher power but shorter RF pulses from the wiggler. The M2 mirror can be reversed to determine whether the gyrotron microwave beam or the IMP wiggler microwave beam is directed into the MTX tokamak. When the IMP wiggler is in operation, the gyrotron will be used as the master oscillator to drive the wiggler

  4. Solid-state gyrotron body power supply, test results

    Energy Technology Data Exchange (ETDEWEB)

    Santinelli, M. [Association Euratom-ENEA, ENEA CR Frascati, 00044 Frascati (Italy)], E-mail: santinelli@frascati.enea.it; Claesen, R.; Coletti, A. [Association Euratom-ENEA, ENEA CR Frascati, 00044 Frascati (Italy); Bonicelli, T.; Mondino, P.L. [EFDA, EFDA CSU Garching, D-85748 Garching (Germany); Pretelli, M.; Rinaldi, L.; Sita, L.; Taddia, G. [OCEM SpA, Via 2 Agosto 1980 no. 11, 40016 San Giorgio di Piano (Italy)

    2007-10-15

    A 170 GHz, 2 MW, steady-state gyrotron is being developed in collaboration between European research associations and industries to be used for the electron cyclotron resonance heating (ECRH) system of ITER, the gyrotron is presently in the prototype state. EFDA entrusted ENEA with the design of a new power supply for the gyrotron's body; in which, the traditional power vacuum tubes are replaced with solid-state components (IGBT); furthermore ENEA had the task of developing the new body power supply (BPS), following the initial conceptual design. The BPS is formed by 50 identical bidirectional (in current) modules, connected in series; the BPS's control system regulates the output voltage by changing the modulation index. OCEM Spa, under ENEA's supervision, has manufactured the BPS. Tests, done at the start of this year, showed the substantial agreement between the initial technical specifications and the values achieved. Particularly the ramp-up/down-emergency time (50-10 {mu}s), the accuracy ({+-}0.5%), the sine wave modulation (45-20 kV at 5 kHz) and the maximum phase shift (<10 deg.) have been tested. In the article, the new stair-way modulation (SWM) scheme will be sketched and the test results will be described in detail.

  5. Investigations and advanced concepts on gyrotron interaction modeling and simulations

    Science.gov (United States)

    Avramidis, K. A.

    2015-12-01

    In gyrotron theory, the interaction between the electron beam and the high frequency electromagnetic field is commonly modeled using the slow variables approach. The slow variables are quantities that vary slowly in time in comparison to the electron cyclotron frequency. They represent the electron momentum and the high frequency field of the resonant TE modes in the gyrotron cavity. For their definition, some reference frequencies need to be introduced. These include the so-called averaging frequency, used to define the slow variable corresponding to the electron momentum, and the carrier frequencies, used to define the slow variables corresponding to the field envelopes of the modes. From the mathematical point of view, the choice of the reference frequencies is, to some extent, arbitrary. However, from the numerical point of view, there are arguments that point toward specific choices, in the sense that these choices are advantageous in terms of simulation speed and accuracy. In this paper, the typical monochromatic gyrotron operation is considered, and the numerical integration of the interaction equations is performed by the trajectory approach, since it is the fastest, and therefore it is the one that is most commonly used. The influence of the choice of the reference frequencies on the interaction simulations is studied using theoretical arguments, as well as numerical simulations. From these investigations, appropriate choices for the values of the reference frequencies are identified. In addition, novel, advanced concepts for the definitions of these frequencies are addressed, and their benefits are demonstrated numerically.

  6. Experimental results of series gyrotrons for the stellarator W7-X

    International Nuclear Information System (INIS)

    A powerful ECRH system with 10 MW RF power at 140 GHz and CW operation is foreseen for the stellarator W7-X, being under construction at IPP Greifswald. The RF power will be delivered by 10 gyrotrons, each capable of 1 MW, CW. Nine gyrotrons are being manufactured by Thales Electron Devices (TED), Velizy, France, one gyrotron was produced by CPI, Palo Alto, CA. Testing of the TED gyrotrons is performed at the test stand at FZK (pulse duration 3 min) and the final tests are performed at IPP (pulse length 30 min). Both, the first TED series gyrotron and the CPI gyrotron have passed the acceptance tests successfully. The acceptance tests of the TED series gyrotrons are ongoing. The RF output beam quality of all tubes tested so far is at a constant high level of about 97% in the Gaussian beam. In short pulse operation the gyrotrons have achieved the specified parameters. However, for long pulse operation the performance decreases due to the occurrence of parasitic oscillations which are assumed to be excited by the electron beam in the beam tunnel close to the cavity. Experimental results of this effect and possible modifications of the beam tunnel geometry will be discussed. (author)

  7. Faculty and organizational characteristics associated with informatics/health information technology adoption in DNP programs.

    Science.gov (United States)

    Fulton, Cathy R; Meek, Julie A; Walker, Patricia Hinton

    2014-01-01

    Nursing informatics/health information technology are key components of graduate nursing education and an accreditation requirement, yet little is known about the extent to which doctor of nursing practice (DNP) curricula include these content domains. The purpose of this descriptive study was to elicit perceptions of DNP program directors relative to (a) whether and how the American Association of Colleges of Nursing's (AACN's) Essential IV standard has been met in their DNP programs; (b) whether the Technology Informatics Guiding Educational Reform Initiative Foundation's Phase II competencies have been integrated in their programs; and (c) the faculty and organizational characteristics associated with the adoption of the AACN's Essential IV. In 2011, an electronic survey was sent to all 138 DNP program directors identified on the AACN Web site with an 81.2% response rate. Findings include variation in whether and how programs have integrated informatics/health information technology content, a lack of informatics-certified and/or master's-prepared faculty, and a perceived lack of faculty awareness of informatics curricular guidelines. DNP program director and dean awareness and support of faculty informatics education, use of informatics competency guidelines, and national policy and stimulus funding support are recommended to promote curricular inclusion and the engagement of nurses in strong informatics practices.

  8. Faculty and organizational characteristics associated with informatics/health information technology adoption in DNP programs.

    Science.gov (United States)

    Fulton, Cathy R; Meek, Julie A; Walker, Patricia Hinton

    2014-01-01

    Nursing informatics/health information technology are key components of graduate nursing education and an accreditation requirement, yet little is known about the extent to which doctor of nursing practice (DNP) curricula include these content domains. The purpose of this descriptive study was to elicit perceptions of DNP program directors relative to (a) whether and how the American Association of Colleges of Nursing's (AACN's) Essential IV standard has been met in their DNP programs; (b) whether the Technology Informatics Guiding Educational Reform Initiative Foundation's Phase II competencies have been integrated in their programs; and (c) the faculty and organizational characteristics associated with the adoption of the AACN's Essential IV. In 2011, an electronic survey was sent to all 138 DNP program directors identified on the AACN Web site with an 81.2% response rate. Findings include variation in whether and how programs have integrated informatics/health information technology content, a lack of informatics-certified and/or master's-prepared faculty, and a perceived lack of faculty awareness of informatics curricular guidelines. DNP program director and dean awareness and support of faculty informatics education, use of informatics competency guidelines, and national policy and stimulus funding support are recommended to promote curricular inclusion and the engagement of nurses in strong informatics practices. PMID:25150414

  9. Infrared monitoring of 110 GHz gyrotron windows at DIII-D

    International Nuclear Information System (INIS)

    The combination of low millimeter wave losses and excellent thermal conductivity with good mechanical properties make artificial chemical vapor deposition (CVD) diamonds a compelling choice for 1 MW 110 GHz gyrotron windows. Five gyrotrons are currently operating at the DIII-D tokamak. Three Gycom gyrotrons have boron nitride (BN) ceramic windows. Due to temperature increases of the windows up to about 930 deg. C, the pulse duration of these tubes is limited to 2 s for output power near 800 kW. Two Communications and Power Industries (CPI) gyrotrons with diamond windows are also installed and operating. The diamond disks of these windows and the construction of their water-cooling assemblies are different. This paper reviews the infrared (IR) measurements of both types of gyrotron windows, with emphasis on the two diamond designs. (authors)

  10. Experimental results of the 1 MW, 140 GHz, CW gyrotron for W7-X

    International Nuclear Information System (INIS)

    A 10 MW ECRH system will be provided by FZK in collaboration with several European associations for the stellarator W7-X. The RF power will be delivered by 10 gyrotrons operating at 140 GHz in CW with 1 MW each. The development of this gyrotron has been performed within a European collaboration in an industrial frame. Two R and D tubes have been built, up to know one serial tube has been passed the acceptance tests. The design of the gyrotron will be described and short pulse and long pulse results of the first serial gyrotron will be discussed. This gyrotron has been successfully operated at more then 900 kW with a pulse length of 30 min. (author)

  11. Infrared Monitoring of 110 GHz Gyrotron Windows at Diii-D

    Science.gov (United States)

    Gorelov, Y.; Lohr, J.; Callis, R. W.; Ponce, D.

    2003-02-01

    The combination of low millimeter wave losses and excellent thermal conductivity with good mechanical properties make artificial chemical vapor deposition (CVD) diamonds a compelling choice for 1 MW 110 GHz gyrotron windows. Five gyrotrons are currently operating at the DIII-D tokamak. Three Gycom gyrotrons have boron nitride (BN) ceramic windows. Due to temperature increases of the windows up to about 930°C, the pulse duration of these tubes is limited to 2 s for output power near 800 kW. Two Communications and Power Industries (CPI) gyrotrons with diamond windows are also installed and operating. The diamond disks of these windows and the construction of their water-cooling assemblies are different. This paper reviews the infrared (IR) measurements of both types of gyrotron windows, with emphasis on the two diamond designs.

  12. Possibilities for Continuous Frequency Tuning in Terahertz Gyrotrons with Nontunable Electrodynamic Systems

    Science.gov (United States)

    Bratman, V. L.; Savilov, A. V.; Chang, T. H.

    2016-02-01

    Large ohmic losses in the cavities of terahertz gyrotrons may lead to the overlapping of the axial mode spectra. In a number of gyrotron experiments, this effect has been used to provide a fairly broadband frequency tuning by changing appropriately the operating magnetic field and/or accelerating voltage of the gyrotron. Similar to the systems with nonfixed axial structure of the RF electromagnetic field and low diffraction quality, which are due to weak reflections of the operating wave from the collector end of the electrodynamic system, this changing leads to a monotonic change in the axial index of the operating wave and transition from the gyrotron regime to the gyro-BWO regime. According to a theoretical comparison of these two methods performed on the basis of generalization of self-consistent gyrotron equations with allowance for variations in the axial electron momenta, low-reflection systems can provide a higher efficiency and monotonicity of the frequency tuning.

  13. Research on a 170 GHz, 2 MW coaxial cavity gyrotron with inner-outer corrugation

    Energy Technology Data Exchange (ETDEWEB)

    Hou, Shenyong, E-mail: houshenyong@sohu.com [Yangtze Normal University, Chongqing, 408001 (China); Yu, Sheng; Li, Hongfu [University of Electronics Science and Technology of China, Chengdu 610054 (China)

    2015-03-15

    In this paper, a coaxial cavity gyrotron with inner-outer corrugation is researched. The electron kineto-equations and the first order transmission line equations of the gyrotron are derived from Lorentz force equation and the transmission line theory, respectively. And then, a 2 MW, 170 GHz coaxial cavity gyrotron with inner-outer corrugation is designed. By means of numerical calculation, the beam-wave interaction of the coaxial cavity gyrotron with inner-outer corrugation is investigated. Results show that the efficient and the outpower of the gyrotron are 42.3% and 2.38 MW, respectively.

  14. Demonstration of dnp groups on the draining lymph node cells of guinea pigs following skin painting with DNCB by peroxidase labelled antibody method.

    Directory of Open Access Journals (Sweden)

    Tada,Hiroshi

    1981-06-01

    Full Text Available The distribution of 2,4-dinitrophenyl (DNP groups in the draining lymph nodes of guinea pigs 12 h after painting the skin with 2,4-dinitrochlorobenzene (DNCB was examined by a peroxidase labelled antibody method using antibody against DNP groups. DNP groups were detected on cells that were found mainly in the subcapsular sinus of the lymph nodes. Electron microscopic examination showed DNP groups distributed on the surface of lymphocytes. The significance of these findings is discussed.

  15. High power 303 GHz gyrotron for CTS in LHD

    Science.gov (United States)

    Yamaguchi, Y.; Kasa, J.; Saito, T.; Tatematsu, Y.; Kotera, M.; Kubo, S.; Shimozuma, T.; Tanaka, K.; Nishiura, M.

    2015-10-01

    A high-power pulsed gyrotron is under development for 300 GHz-band collective Thomson scattering (CTS) diagnostics in the Large Helical Device (LHD). High-density plasmas in the LHD require a probe wave with power exceeding 100 kW in the sub-terahertz region to obtain sufficient signal intensity and large scattering angles. At the same time, the frequency bandwidth should be less than several tens of megahertz to protect the CTS receiver using a notch filter against stray radiations. Moreover, duty cycles of ~ 10% are desired for the time domain analysis of the CTS spectrum. At present, a 77 GHz gyrotron for electron cyclotron heating is used as a CTS wave source in the LHD. However, the use of such a low-frequency wave suffers from refraction, cutoff and absorption at the electron cyclotron resonance layer. Additionally, the signal detection is severely affected by background noise from electron cyclotron emission. To resolve those problems, high-power gyrotrons in the 300 GHz range have been developed. In this frequency range, avoiding mode competition is critical to realizing high-power and stable oscillation. A moderately over-moded cavity was investigated to isolate a desired mode from neighbouring modes. After successful tests with a prototype tube, the practical one was constructed with a cavity for TE22,2 operation mode, a triode electron gun forming intense laminar electron beams, and an internal mode convertor. We have experimentally confirmed single mode oscillation of the TE22,2 mode at the frequency of 303.3 GHz. The spectrum peak is sufficiently narrow. The output power of 290 kW has been obtained at the moment.

  16. Influence of construction concepts on training behavior of gyrotron magnets

    International Nuclear Information System (INIS)

    A series of 60 NbTi gyrotron magnets intended mainly for high frequency plasma heating complexes at Tokamak T-10 and Tokamak T-15, and prototypes and later improved versions for the same applications within ITER project, were developed and tested. A variety of constructional and technological concepts was applied. As a result of empirical experience in parallel with the application of established theoretical models to the magnet development, a remarkable improvement in winding mechanical stability was reached. The differences in magnet winding construction are related to operational as well as training and quench behaviour. (Author)

  17. A 2 MW, 170 GHz coaxial cavity gyrotron - experimental verification of the design of main components

    International Nuclear Information System (INIS)

    A 2 MW, CW, 170 GHz coaxial cavity gyrotron is under development in cooperation between European Research Institutions (FZK Karlsruhe, CRPP Lausanne, HUT Helsinki) and the European tube industry (TED, Velizy, France). The design of critical components has recently been examined experimentally at FZK Karlsruhe with a short pulse (∼ few ms) coaxial cavity gyrotron. This gyrotron uses the same cavity and the same quasioptical (q.o.) RF-output system as designed for the industrial prototype and a very similar electron gun

  18. HIGH POWER LONG PULSE PERFORMANCE OF THE DIII-D GYROTRON INSTALLATION

    Energy Technology Data Exchange (ETDEWEB)

    J. LOHR; Y.A. GORELOV; R.W. CALLIS; H.J. GRUNLOH; J.J. PEAVY; R.I. PINSKER; D. PONCE; R. PRATER; R.A. ELLIS,III

    2002-05-01

    At DIII-D, five 110 GHz gyrotrons are operating routinely for 2.0 s pulses at generated power levels {ge}750 kW per gyrotron. A sixth gyrotron is being installed, which should bring the generated power level to >4 MW and the injected power to about 3.0 MW. The output power now can be modulated by the plasma control system to fix T{sub e} at a desired value. The system is being used as a tool for control of current diffusion, for current profile control and other experiments leading to advanced tokamak operation.

  19. 140 GHz gyrotron development program. Quarterly report No. 4, January-March 1985

    International Nuclear Information System (INIS)

    The objective of this program is to develop a gyrotron oscillator capable of producing 100 kW CW at 140 GHz. Further analysis of the electron guns, interaction cavity, and beam tunnel designs for the first two experimental tubes, Experimental Tube 1 and preprototype Tube 1, is presented. A window deflection tester has been built and initial deflection test results are given. The first 140 GHz gyrotron magnet has successfully passed the major points in the acceptance test. The detailed results of the magnet acceptance test are discussed. Progress concerning the fabrication of 149 GHz gyrotron components, diagnostics, and protective devices, as well as the status of Experimental Tube 1, are summarized

  20. Magnetic resonance imaging of DNP enhancements in a rotor spinning at the magic angle.

    Science.gov (United States)

    Perras, Frédéric A; Kobayashi, Takeshi; Pruski, Marek

    2016-03-01

    Simulations performed on model, static, samples have shown that the microwave power is non-uniformly distributed in the magic angle spinning (MAS) rotor when using conventional dynamic nuclear polarization (DNP) instrumentation. Here, we applied the stray-field magic angle spinning imaging (STRAFI-MAS) experiment to generate a spatial map of the DNP enhancements in a full rotor, which is spun at a low rate in a commercial DNP-MAS NMR system. Notably, we observed that the enhancement factors produced in the center of the rotor can be twice as large as those produced at the top of the rotor. Surprisingly, we observed that the largest enhancement factors are observed along the axis of the rotor as opposed to against its walls, which are most directly irradiated by the microwave beam. We lastly observed that the distribution of enhancement factors can be moderately improved by degassing the sample and increasing the microwave power. The inclusion of dielectric particles greatly amplifies the enhancement factors throughout the rotor. The STRAFI-MAS approach can provide useful guidance for optimizing the access of microwave power to the sample, and thereby lead to further increases in sensitivity of DNP-MAS NMR.

  1. Evaluating resilience of DNP3-controlled SCADA systems against event buffer flooding

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Guanhua [Los Alamos National Laboratory; Nicol, David M [UNIV OF IL; Jin, Dong [UNIV OF IL

    2010-12-16

    The DNP3 protocol is widely used in SCADA systems (particularly electrical power) as a means of communicating observed sensor state information back to a control center. Typical architectures using DNP3 have a two level hierarchy, where a specialized data aggregator device receives observed state from devices within a local region, and the control center collects the aggregated state from the data aggregator. The DNP3 communication between control center and data aggregator is asynchronous with the DNP3 communication between data aggregator and relays; this leads to the possibility of completely filling a data aggregator's buffer of pending events, when a relay is compromised or spoofed and sends overly many (false) events to the data aggregator. This paper investigates how a real-world SCADA device responds to event buffer flooding. A Discrete-Time Markov Chain (DTMC) model is developed for understanding this. The DTMC model is validated by a Moebius simulation model and data collected on real SCADA testbed.

  2. The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1.

    Science.gov (United States)

    Li, Gang; Cunin, Pierre; Wu, Di; Diogo, Dorothée; Yang, Yu; Okada, Yukinori; Plenge, Robert M; Nigrovic, Peter A

    2016-09-01

    Understanding the implications of genome-wide association studies (GWAS) for disease biology requires both identification of causal variants and definition of how these variants alter gene function. The non-coding triallelic dinucleotide polymorphism CCR6DNP is associated with risk for rheumatoid arthritis, and is considered likely causal because allelic variation correlates with expression of the chemokine receptor CCR6. Using transcription activator-like effector nuclease (TALEN) gene editing, we confirmed that CCR6DNP regulates CCR6. To identify the associated transcription factor, we applied a novel assay, Flanking Restriction Enhanced Pulldown (FREP), to identify specific association of poly (ADP-ribose) polymerase 1 (PARP-1) with CCR6DNP consistent with the established allelic risk hierarchy. Correspondingly, manipulation of PARP-1 expression or activity impaired CCR6 expression in several lineages. These findings show that CCR6DNP is a causal variant through which PARP-1 regulates CCR6, and introduce a highly efficient approach to interrogate non-coding genetic polymorphisms associated with human disease. PMID:27626929

  3. A 140 GHz pulsed EPR/212 MHz NMR spectrometer for DNP studies

    Science.gov (United States)

    Smith, Albert A.; Corzilius, Björn; Bryant, Jeffrey A.; DeRocher, Ronald; Woskov, Paul P.; Temkin, Richard J.; Griffin, Robert G.

    2012-10-01

    We described a versatile spectrometer designed for the study of dynamic nuclear polarization (DNP) at low temperatures and high fields. The instrument functions both as an NMR spectrometer operating at 212 MHz (1H frequency) with DNP capabilities, and as a pulsed-EPR operating at 140 GHz. A coiled TE011 resonator acts as both an NMR coil and microwave resonator, and a double balanced (1H, 13C) radio frequency circuit greatly stabilizes the NMR performance. A new 140 GHz microwave bridge has also been developed, which utilizes a four-phase network and ELDOR channel at 8.75 GHz, that is then multiplied and mixed to obtain 140 GHz microwave pulses with an output power of 120 mW. Nutation frequencies obtained are as follows: 6 MHz on S = 1/2 electron spins, 100 kHz on 1H, and 50 kHz on 13C. We demonstrate basic EPR, ELDOR, ENDOR, and DNP experiments here. Our solid effect DNP results demonstrate an enhancement of 144 and sensitivity gain of 310 using OX063 trityl at 80 K and an enhancement of 157 and maximum sensitivity gain of 234 using Gd-DOTA at 20 K, which is significantly better performance than previously reported at high fields (⩾3 T).

  4. Impact of Gd3+ doping and glassing solvent deuteration on 13C DNP at 5 Tesla

    Science.gov (United States)

    Kiswandhi, Andhika; Lama, Bimala; Niedbalski, Peter; Goderya, Mudrekh; Long, Joanna; Lumata, Lloyd

    Dynamic nuclear polarization (DNP) is a technique which can be used to amplify signals in nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) by several thousand-fold. The most commonly available DNP system typically operates at the W-band field or 3.35 T, at which it has been shown that 13C NMR signal can be enhanced by deuteration and Gd3+ doping. In this work, we have investigated the applicability of these procedures at 5 T. Our results indicate that the deuteration of the glassing matrix still yields an enhancement of 13C DNP when 4-oxo-TEMPO free radical is used. The effect is attributed to the lower heat load of the deuterons compared to protons. An addition of a trace amount of Gd3+ gives a modest enhancement of the signal when trityl OX063 is used, albeit with a less pronounced relative enhancement compared to the results obtained at 3.35 T. The results suggest that the enhancement obtained via Gd3+ doping may become saturated at higher field. These results will be discussed using a thermodynamic model of DNP. This work is supported by US Dept of Defense Award No. W81XWH-14-1-0048 and Robert A. Welch Foundation Grant No. AT-1877.

  5. Application of Fusion Gyrotrons to Enhanced Geothermal Systems (EGS)

    Science.gov (United States)

    Woskov, P.; Einstein, H.; Oglesby, K.

    2013-10-01

    The potential size of geothermal energy resources is second only to fusion energy. Advances are needed in drilling technology and heat reservoir formation to realize this potential. Millimeter-wave (MMW) gyrotrons and related technologies developed for fusion energy research could contribute to enabling EGS. Directed MMW energy can be used to advance rock penetration capabilities, borehole casing, and fracking. MMWs are ideally suited because they can penetrate through small particulate extraction plumes, can be efficiently guided long distances in borehole dimensions, and continuous megawatt sources are commercially available. Laboratory experiments with a 10 kW, 28 GHz CPI gyrotron have shown that granite rock can be fractured and melted with power intensities of about 1 kW/cm2 and minute exposure times. Observed melted rock MMW emissivity and estimated thermodynamics suggest that penetrating hot, hard crystalline rock formations may be economic with fusion research developed MMW sources. Supported by USDOE, Office of Energy Efficiency and Renewable Energy and Impact Technologies, LLC.

  6. A Two Frequency 1.5 MW Gyrotron Experiment

    Science.gov (United States)

    Tax, David; Guss, William; Shapiro, Michael; Temkin, Richard; Rock, Ben; Vernon, Ronald; Neilson, Jeffrey

    2012-10-01

    Megawatt gyrotrons are an important microwave source for electron cyclotron heating and current drive (ECH/ECCD) in fusion plasmas due to their ability to produce megawatts of power at millimeter wave frequencies. The MIT gyrotron operates nominally at 96 kV and 40 A with 3 μs pulses and has previously demonstrated 1.5 MW of output power with > 50 % efficiency at 110 GHz with a depressed collector. A new cavity has been designed for 1.5 MW operation at two distinct frequencies: 110 GHz in the TE22,6 mode and 124.5 GHz in the TE24,7 mode. A new internal mode converter (IMC) consisting of a dimpled wall launcher and four smooth curved mirrors has also been designed and was optimized for both modes. Simulations of the IMC indicate that > 98 % Gaussian beam content could be achieved for each mode. Cold test results for the components will be presented as well as the current status of the hot test experiment.

  7. Design and characterization of a W-band system for modulated DNP experiments

    Science.gov (United States)

    Guy, Mallory L.; Zhu, Lihuang; Ramanathan, Chandrasekhar

    2015-12-01

    Magnetic-field and microwave-frequency modulated DNP experiments have been shown to yield improved enhancements over conventional DNP techniques, and even to shorten polarization build-up times. The resulting increase in signal-to-noise ratios can lead to significantly shorter acquisition times in signal-limited multi-dimensional NMR experiments and pave the way to the study of even smaller sample volumes. In this paper we describe the design and performance of a broadband system for microwave frequency- and amplitude-modulated DNP that has been engineered to minimize both microwave and thermal losses during operation at liquid helium temperatures. The system incorporates a flexible source that can generate arbitrary waveforms at 94 GHz with a bandwidth greater than 1 GHz, as well as a probe that efficiently transmits the millimeter waves from room temperature outside the magnet to a cryogenic environment inside the magnet. Using a thin-walled brass tube as an overmoded waveguide to transmit a hybrid HE11 mode, it is possible to limit the losses to 1 dB across a 2 GHz bandwidth. The loss is dominated by the presence of a quartz window used to isolate the waveguide pipe. This performance is comparable to systems with corrugated waveguide or quasi-optical components. The overall excitation bandwidth of the probe is seen to be primarily determined by the final antenna or resonator used to excite the sample and its coupling to the NMR RF coil. Understanding the instrumental limitations imposed on any modulation scheme is key to understanding the observed DNP results and potentially identifying the underlying mechanisms. We demonstrate the utility of our design with a set of triangular frequency-modulated DNP experiments.

  8. The Chemical Uncoupler 2,4-Dinitrophenol (DNP) Protects against Diet-induced Obesity and Improves Energy Homeostasis in Mice at Thermoneutrality*

    Science.gov (United States)

    Goldgof, Margalit; Xiao, Cuiying; Chanturiya, Tatyana; Jou, William; Gavrilova, Oksana; Reitman, Marc L.

    2014-01-01

    The chemical uncoupler 2,4-dinitrophenol (DNP) was an effective and widely used weight loss drug in the early 1930s. However, the physiology of DNP has not been studied in detail because toxicity, including hyperthermia and death, reduced interest in the clinical use of chemical uncouplers. To investigate DNP action, mice fed a high fat diet and housed at 30 °C (to minimize facultative thermogenesis) were treated with 800 mg/liter DNP in drinking water. DNP treatment increased energy expenditure by ∼17%, but did not change food intake. DNP-treated mice weighed 26% less than controls after 2 months of treatment due to decreased fat mass, without a change in lean mass. DNP improved glucose tolerance and reduced hepatic steatosis without observed toxicity. DNP treatment also reduced circulating T3 and T4 levels, Ucp1 expression, and brown adipose tissue activity, demonstrating that DNP-mediated heat generation substituted for brown adipose tissue thermogenesis. At 22 °C, a typical vivarium temperature that is below thermoneutrality, DNP treatment had no effect on body weight, adiposity, or glucose homeostasis. Thus, environmental temperature should be considered when assessing an anti-obesity drug in mice, particularly agents acting on energy expenditure. Furthermore, the beneficial effects of DNP suggest that chemical uncouplers deserve further investigation for the treatment of obesity and its comorbidities. PMID:24872412

  9. The chemical uncoupler 2,4-dinitrophenol (DNP) protects against diet-induced obesity and improves energy homeostasis in mice at thermoneutrality.

    Science.gov (United States)

    Goldgof, Margalit; Xiao, Cuiying; Chanturiya, Tatyana; Jou, William; Gavrilova, Oksana; Reitman, Marc L

    2014-07-11

    The chemical uncoupler 2,4-dinitrophenol (DNP) was an effective and widely used weight loss drug in the early 1930s. However, the physiology of DNP has not been studied in detail because toxicity, including hyperthermia and death, reduced interest in the clinical use of chemical uncouplers. To investigate DNP action, mice fed a high fat diet and housed at 30 °C (to minimize facultative thermogenesis) were treated with 800 mg/liter DNP in drinking water. DNP treatment increased energy expenditure by ∼ 17%, but did not change food intake. DNP-treated mice weighed 26% less than controls after 2 months of treatment due to decreased fat mass, without a change in lean mass. DNP improved glucose tolerance and reduced hepatic steatosis without observed toxicity. DNP treatment also reduced circulating T3 and T4 levels, Ucp1 expression, and brown adipose tissue activity, demonstrating that DNP-mediated heat generation substituted for brown adipose tissue thermogenesis. At 22 °C, a typical vivarium temperature that is below thermoneutrality, DNP treatment had no effect on body weight, adiposity, or glucose homeostasis. Thus, environmental temperature should be considered when assessing an anti-obesity drug in mice, particularly agents acting on energy expenditure. Furthermore, the beneficial effects of DNP suggest that chemical uncouplers deserve further investigation for the treatment of obesity and its comorbidities. PMID:24872412

  10. Numerical study on a 0.4 THz second harmonic gyrotron with high power

    International Nuclear Information System (INIS)

    Terahertz and sub-terahertz science and technology are promising topics today. However, it is difficult to obtain high power source of terahertz wave. In this paper, the mode competition and beam-wave interaction in a gradually tapered cavity are studied to achieve high efficiency of a 0.4THz second harmonic gyrotron in practice. In order to attain high power and stable radiation, the TE32,5 mode is selected as the operating mode of the desired gyrotron to realize single mode oscillation. The issues of studying on the high-order mode gyrotrons are solved effectively by transforming the generalized telegraphist's equations. The efficiency and output power of the gyrotron under different conditions have been calculated by the code, which is based on the transformed equations. Consequently, the results show that single mode second harmonic radiation with power of over 150 kW at frequency of 0.4 THz could be achieved

  11. Cold test of cylindrical open resonator for 42 GHz, 200 kW gyrotron

    Indian Academy of Sciences (India)

    Vivek Yadav; Sudeep Sharan; Hasina Khatun; Nitin Kumar; M K Alaria; B Jha; S C Deorani; A K Sinha; P K Jain

    2013-12-01

    This paper presents experimental results for cold testing of a gyrotron open resonator. Experiments were carried out to measure resonant frequency and their particular quality factor for TE mode at the frequency 42 GHz. The perturbation technique was used to determine the axial, radial and azimuthal electric field profile for identification of TE031 mode at operating frequency 42 GHz. The good agreement between experimental results and theoretical studies was found. The results verify the design and fabrication of the specific gyrotron cavity.

  12. Gyrotron physics from linear to chaotic regimes: experiment and numerical modeling

    OpenAIRE

    Braunmüller, Falk Hans

    2016-01-01

    Gyrotrons belong to the family of high-power coherent radiation sources known as Electron Cyclotron Masers (ECMs) and are based on the physical mechanism of the ECM-instability, converting electron rotational kinetic energy into coherent electromagnetic radiation. The worldwide gyrotron R&D is mainly driven by the application in heating a magnetically confined fusion plasma, which requires coherent radiation sources with MW power-level in the sub-THz frequency range. In the last two decades,...

  13. 1.5 MW, 110 GHz Gyrotron with a Depressed Collector

    Science.gov (United States)

    Choi, Eunmi; Anderson, James; Shapiro, Michael; Jagadishwar, Sirigiri; Temkin, Richard

    2004-11-01

    A 1.5 MW, 110 GHz gyrotron is under development for electron cyclotron resonance plasma heating at DIII-D. Research conducted at MIT in short pulse operation is aimed at providing data on the operation of the gyrotron at very high efficiency. The 1.5 MW gyrotron design is based on previous successful results from the 1 MW gyrotrons built by Communication and Power Industries (CPI). A TE_22,6 mode cavity is utilized with an electron beam voltage of 96 kV and a beam current of 40 A. Recently we have successfully run the gyrotron in the axial configuration, and the experimental peak power was 1.44 MW at 37 % efficiency, when operating in the TE_22,6 mode. We have rebuilt this experiment in a configuration which has an internal mode converter and depressed collector, which should enhance the efficiency (> 50 %). The internal mode converter of the TE_22,6 mode to a Gaussian beam consists of an irregular waveguide launcher and four quasi-optical mirrors. A new cavity that provides greatly reduced Ohmic heating on the wall has been designed to enhance the gyrotron efficiency. This cavity will be tested in the next stage of the experiment.

  14. Optimization of operation of a three-electrode gyrotron with the use of a flow-type calorimeter

    Energy Technology Data Exchange (ETDEWEB)

    Kharchev, Nikolay K.; Batanov, German M.; Kolik, Leonid V.; Malakhov, Dmitrii V.; Petrov, Aleksandr Ye.; Sarksyan, Karen A.; Skvortsova, Nina N.; Stepakhin, Vladimir D. [Prokhorov General Physics Institute, Vavilova ul. 38, Moscow 119991 (Russian Federation); Belousov, Vladimir I. [Institute of Applied Physics, Ul' yanova ul. 46, Nizhnii Novgorod 603950 (Russian Federation); Malygin, Sergei A.; Tai, Yevgenii M. [GYCOM Company, Ul' yanova ul. 46, Nizhnii Novgorod 603155 (Russian Federation)

    2013-01-15

    Results are presented for measurements of microwave power of the Borets-75/0.8 gyrotron with recovery of residual electron energy, which were performed by a flow-type calorimeter. This gyrotron is a part of the ECR plasma heating complex put into operation in 2010 at the L-2M stellarator. The new calorimeter is capable of measuring microwave power up to 0.5 MW. Monitoring of the microwave power makes it possible to control the parameters of the gyrotron power supply unit (its voltage and current) and the magnetic field of the cryomagnet in order to optimize the gyrotron operation and arrive at maximum efficiency.

  15. Hiring Intentions of Directors of Nursing Programs Related to DNP- and PhD-Prepared Faculty and Roles of Faculty.

    Science.gov (United States)

    Oermann, Marilyn H; Lynn, Mary R; Agger, Charlotte A

    2016-01-01

    This study surveyed administrators of associate degree in nursing (ADN) and bachelor of science in nursing (BSN) programs across the United States to identify hiring intentions and describe the roles and responsibilities of DNP- and PhD-prepared faculty members. The final sample included 253 ADN and 229 BSN programs. ADN programs were neither intentionally hiring nor looking to hire doctorally prepared nurse faculty. Deans and directors of BSN programs reported an average of 3 openings for the next academic year, 2 projected for new PhD-prepared faculty and 1 for a faculty member with a DNP. Schools have made varying decisions regarding the type of appointment (tenure or nontenure track) for DNP-prepared faculty members. Challenges that DNP-prepared faculty members encountered in meeting the role and promotion expectations in their schools focused predominantly on scholarship. PMID:27216125

  16. Hiring Intentions of Directors of Nursing Programs Related to DNP- and PhD-Prepared Faculty and Roles of Faculty.

    Science.gov (United States)

    Oermann, Marilyn H; Lynn, Mary R; Agger, Charlotte A

    2016-01-01

    This study surveyed administrators of associate degree in nursing (ADN) and bachelor of science in nursing (BSN) programs across the United States to identify hiring intentions and describe the roles and responsibilities of DNP- and PhD-prepared faculty members. The final sample included 253 ADN and 229 BSN programs. ADN programs were neither intentionally hiring nor looking to hire doctorally prepared nurse faculty. Deans and directors of BSN programs reported an average of 3 openings for the next academic year, 2 projected for new PhD-prepared faculty and 1 for a faculty member with a DNP. Schools have made varying decisions regarding the type of appointment (tenure or nontenure track) for DNP-prepared faculty members. Challenges that DNP-prepared faculty members encountered in meeting the role and promotion expectations in their schools focused predominantly on scholarship.

  17. Effects of DNP on the cell surface properties of marine bacteria and its implication for adhesion to surfaces

    Digital Repository Service at National Institute of Oceanography (India)

    Jain, A.; Nishad, K.K.; Bhosle, N.B.

    The effect of 2, 4-dinitrophenol (DNP) on extracelluar polysaccharides (EPS), cell surface charge, and hydrophobicity of six marine bacterial cultures was studied, and its influence on attachment of these bacteria to glass and polystyrene...

  18. Gyrotron development at the Instituto de Pesquisas Espaciais

    International Nuclear Information System (INIS)

    The conceptual design of a 35GHz gyrotron operating in the TE021 mode, intended for plasma heating experiments, is presented. The electrooptical system is synthesized from the electron beam parameters in the cavity region and the electrodynamical system includes a conventional resonator consisting of truncated cones. The starting and operating characteristics are calculated by integrating the exact equation of electron motion under the action of an RF fiel with fixed spatial distribution. For the moment, the experimental activities, in addition to providing all the infrastructure for the laboratory, are concentrated on the construction of a system of magnetic coils, able to generated a 15kG magnetic induction with a fluctuation of 0.1% over an extension of 13cm, on the manufacture of cavities by using electroforming techniques and on the development of techniques for the construction of electron guns. (author)

  19. Gain/bandwidth predictions for travelling-wave gyrotron

    Science.gov (United States)

    Sangster, A. J.

    1980-10-01

    Small signal gain computations based on a Pierce description of the traveling-wave gyrotron have been performed for cases involving beam voltages in the range 70-300 kV. Interactions at both the first and the second harmonics of the cyclotron resonance frequency have been considered in order to identify a range of operating parameters for the gyro-traveling-wave amplifier configuration which will potentially produce gain and bandwidth figures of significance to radar and communication systems operating at millimeter-wave frequencies. It is shown that when operated fundamentally and well away from cutoff, the gyro-traveling-wave amplifier can be magnetically tuned over a wide frequency range, with instantaneous bandwidths in the range 4-8% depending on the beam voltage; at voltages in excess of 200 kV, instantaneous bandwidths approaching 10% can be achieved.

  20. EPR and DNP Properties of Certain Novel Single Electron Contrast Agents Intended for Oximetric Imaging

    DEFF Research Database (Denmark)

    Ardenkjær-Larsen, J. H.; Laursen, I; Leunbach, I.;

    1998-01-01

    Parameters of relevance to oximetry with Overhauser magnetic resonance imaging (OMRI) have been measured for three single electron contrast agents of the triphenylmethyl type. The single electron contrast agents are stable and water soluble. Magnetic resonance properties of the agents have been...... examined with electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), and dynamic nuclear polarization (DNP) at 9.5 mT in water, isotonic saline, plasma, and blood at 23 and 37°C. The relaxivities of the agents are about 0.2–0.4 mM−1s−1and the DNP enhancements extrapolate close...... to the dipolar limit. The agents have a single, narrow EPR line, which is analyzed as a Voigt function. The linewidth is measured as a function of the agent concentration and the oxygen concentration. The concentration broadenings are about 1–3 μT/mM and the Lorentzian linewidths at infinite dilution are less...

  1. High-resolution NMR of hydrogen in organic solids by DNP enhanced natural abundance deuterium spectroscopy

    Science.gov (United States)

    Rossini, Aaron J.; Schlagnitweit, Judith; Lesage, Anne; Emsley, Lyndon

    2015-10-01

    We demonstrate that high field (9.4 T) dynamic nuclear polarization (DNP) at cryogenic (∼100 K) sample temperatures enables the rapid acquisition of natural abundance 1H-2H cross-polarization magic angle spinning (CPMAS) solid-state NMR spectra of organic solids. Spectra were obtained by impregnating substrates with a solution of the stable DNP polarizing agent TEKPol in tetrachloroethane. Tetrachloroethane is a non-solvent for the solids, and the unmodified substrates are then polarized through spin diffusion. High quality natural abundance 2H CPMAS spectra of histidine hydrochloride monohydrate, glycylglycine and theophylline were acquired in less than 2 h, providing direct access to hydrogen chemical shifts and quadrupolar couplings. The spectral resolution of the 2H solid-state NMR spectra is comparable to that of 1H spectra obtained with state of the art homonuclear decoupling techniques.

  2. Water accessibility in a membrane-inserting peptide comparing Overhauser DNP and pulse EPR methods

    Science.gov (United States)

    Segawa, Takuya F.; Doppelbauer, Maximilian; Garbuio, Luca; Doll, Andrin; Polyhach, Yevhen O.; Jeschke, Gunnar

    2016-05-01

    Water accessibility is a key parameter for the understanding of the structure of biomolecules, especially membrane proteins. Several experimental techniques based on the combination of electron paramagnetic resonance (EPR) spectroscopy with site-directed spin labeling are currently available. Among those, we compare relaxation time measurements and electron spin echo envelope modulation (ESEEM) experiments using pulse EPR with Overhauser dynamic nuclear polarization (DNP) at X-band frequency and a magnetic field of 0.33 T. Overhauser DNP transfers the electron spin polarization to nuclear spins via cross-relaxation. The change in the intensity of the 1H NMR spectrum of H2O at a Larmor frequency of 14 MHz under a continuous-wave microwave irradiation of the nitroxide spin label contains information on the water accessibility of the labeled site. As a model system for a membrane protein, we use the hydrophobic α-helical peptide WALP23 in unilamellar liposomes of DOPC. Water accessibility measurements with all techniques are conducted for eight peptides with different spin label positions and low radical concentrations (10-20 μM). Consistently in all experiments, the water accessibility appears to be very low, even for labels positioned near the end of the helix. The best profile is obtained by Overhauser DNP, which is the only technique that succeeds in discriminating neighboring positions in WALP23. Since the concentration of the spin-labeled peptides varied, we normalized the DNP parameter ɛ, being the relative change of the NMR intensity, by the electron spin concentration, which was determined from a continuous-wave EPR spectrum.

  3. Design and characterization of a W-band system for modulated DNP experiments

    CERN Document Server

    Guy, Mallory L; Ramanathan, Chandrasekhar

    2015-01-01

    Magnetic-field and microwave-frequency modulated DNP experiments have been shown to yield improved enhancements over conventional DNP techniques, and even to shorten polarization build-up times. The resulting increase in signal-to-noise ratios can lead to significantly shorter acquisition times in signal-limited multi-dimensional NMR experiments and pave the way to the study of even smaller sample volumes. In this paper we describe the design and performance of a broadband system for microwave frequency- and amplitude-modulated DNP that has been engineered to minimize both microwave and thermal losses during operation at liquid helium temperatures. The system incorporates a flexible source that can generate arbitrary waveforms at 94 GHz with a bandwidth greater than 1 GHz, as well as a probe that efficiently transmits the millimeter waves from room temperature outside the magnet to a cryogenic environment inside the magnet. Using a thin-walled brass tube as an overmoded waveguide to transmit a hybrid HE11 mod...

  4. Nuclear magnetic resonance studies of DNP-ready trehalose obtained by solid state mechanochemical amorphization.

    Science.gov (United States)

    Filibian, M; Elisei, E; Colombo Serra, S; Rosso, A; Tedoldi, F; Cesàro, A; Carretta, P

    2016-06-22

    (1)H nuclear spin-lattice relaxation and Dynamic Nuclear Polarization (DNP) have been studied in amorphous samples of trehalose sugar doped with TEMPO radicals by means of mechanical milling, in the 1.6-4.2 K temperature range. The radical concentration was varied between 0.34 and 0.81%. The highest polarization of 15% at 1.6 K, observed in the sample with concentration 0.50%, is of the same order of magnitude of that reported in standard frozen solutions with TEMPO. The temperature and concentration dependence of the spin-lattice relaxation rate 1/T1, dominated by the coupling with the electron spins, were found to follow power laws with an exponent close to 3 in all samples. The observed proportionality between 1/T1 and the polarization rate 1/Tpol, with a coefficient related to the electron polarization, is consistent with the presence of Thermal Mixing (TM) and a good contact between the nuclear and the electron spins. At high electron concentration additional relaxation channels causing a decrease in the nuclear polarization must be considered. These results provide further support for a more extensive use of amorphous DNP-ready samples, obtained by means of comilling, in dissolution DNP experiments and possibly for in vivo metabolic imaging.

  5. Millimeter-wave, megawatt gyrotron development for ECR (electron cyclotron resonance) heating applications

    Energy Technology Data Exchange (ETDEWEB)

    Jory, H.; Felch, K.; Hess, C.; Huey, H.; Jongewaard, E.; Neilson, J.; Pendleton, R.; Tsirulnikov, M. (Varian Associates, Inc., Palo Alto, CA (USA))

    1990-09-17

    To address the electron cyclotron heating requirements of planned fusion experiments such as the International Thermonuclear Experimental Reactor (ITER) and the Compact Ignition Tokamak (CIT), Varian is developing gyrotrons at frequencies ranging from 100--300 GHz with output power capabilities up to 1 MW CW. Experimental gyrotrons have been built at frequencies between 100--140 GHz, and a study program has addressed the critical elements of designing 280--300 GHz gyrotrons capable of generating CW power levels up to 1 MW. Initial test vehicles at 140 GHz have utilized TE{sub 15,2,1} interaction cavities, and have been designed to generate short-pulse (up to 20 ms) power levels of 1 MW and up to 400 kW CW. Recently, short-pulse power levels of 1040 kW at 38% efficiency have been obtained and average powers of 200 kW have been achieved. Long-pulse operation has been extended to pulse durations of 0.5 seconds at power levels of 400 kW. Gyrotron oscillators capable of generating output powers of 500 kW CW at a frequency of 110 GHz have recently been designed and a prototype is currently being tested. Design work for a 1 MW CW gyrotron at 110 GHz, is in progress. The 1 MW CW tube will employ an output coupling approach where the microwave output is separated from the microwave output. 15 refs., 10 figs., 3 tabs.

  6. Development of dual frequency gyrotron and high power test of EC components

    Directory of Open Access Journals (Sweden)

    Sakamoto K.

    2012-09-01

    Full Text Available In JAEA, development of high-power long-pulse gyrotrons is underway. The output power of the gyrotron was applied for high-power long-pulse tests of the transmission line (TL and the equatorial launcher (EL mock up for ITER. The feature of design in the dual frequency gyrotron is the simultaneously satisfying the matching of both frequencies at a window and the same radiation angle at an internal mode convertor for both frequencies. The dual frequency gyrotron was developed and high power operations at 170 GHz and 137 GHz were carried out. The 170 GHz high power experiment of 40 m length ITER relevant TL was carried out and transmission efficiency and mode purity change caused by long pulse operation were measured. The mock-up model of EL was also tested using 170 GHz gyrotron. The power transmission through the quasi-optical beam line in EL was demonstrated using the full scale mock up model. Furthermore, the high power test results of the transmission components will be summarized.

  7. The 110 GHz Gyrotron Installation on DIII--D: Status and Experimental Results

    Science.gov (United States)

    Lohr, John; Ponce, Dan; Callis, R. W.; Popov, L.; Zerbini, M.; Cahalan, P.

    1997-11-01

    The 110 GHz installation on DIII--D consists of two gyrotrons each of which operates at generated power levels between 0.5 and 1.0 MW for pulse lengths up to 2.0 s. The gyrotrons are connected to DIII--D by windowless evacuated transmission lines. The greatest experience to date has been accumulated with the Gycom Centaur gyrotron, a diode tube which has been operated reliably at generated rf power levels in excess of 0.80 MW for pulse durations of 2.0 s. This tube has been modulated at 100% depth at frequencies up to 1 kHz. The second gyrotron is a Communications and Power Industries model VGT-8011A, a triode geometry, which is in initial testing. For this gyrotron, collector power loading has been measured, the beam steering has been set and pulse/power extension is in progress. DIII--D tests of the system performance are ongoing and initial tokamak experiments on transport, H--mode physics and scaling have begun.

  8. High power operation of Gaussian beam gyrotron with CVD diamond window for JT-60U

    International Nuclear Information System (INIS)

    A 110 GHz-Gaussian beam output gyrotron with CVD (Chemical Vapor Deposition) diamond window was developed for the electron cyclotron heating and current drive on JT-60U. A stable Gaussian output beam power of 1.1 MW-0.1 s was obtained with the efficiency of 39% with depressed collector operation. Due to Gaussian beam output from the gyrotron, the coupling efficiency to HE11 mode in the mirror optical unit was 94%. Moreover, the transmission efficiency of 89% for HE11 mode was performed at the power level of 1 MW on the 40 m-transmission test line of φ31.751 mm corrugated waveguide and 8-miter bends included 1-pair of polarizer. The gyrotron and transmission line were installed into JT-60U system and 0.6 MW-0.3 s power was successfully injected into JT-60U plasmas as an initial operation

  9. Gyrotron Development in the EU for Present Fusion Experiments and for ITER

    International Nuclear Information System (INIS)

    The long term strategy of the EU in the field of gyrotrons in fusion plasma applications is based on two approaches: R and D in laboratories to develop advanced concepts and industrial development of state-of-the-art tubes for use in present experiments like TCV, Tore Supra (118 GHz, 0.5 MW, CW) and W7-X (140 GHz, 1 MW, CW). The results from these two approaches are then applied to the development of a coaxial cavity gyrotron operating at 170 GHz and delivering 2 MW-CW for the electron cyclotron wave system of ITER. This paper will recall the main achievements of this program and will outline the present status of the 170 GHz coaxial cavity gyrotron development

  10. Control of the Superconducting Magnets current Power Supplies of the TJ-II Gyrotrons

    International Nuclear Information System (INIS)

    The TJ-II ECRH heating system consists of two gyrotrons, which can deliver a maximum power of 300 kW at a frequency of 53.2 GHz. Another 28 GHz gyrotron is going to be used in the Bernstein waves heating system. In order to get the required frequency, the gyrotrons need and homogeneous magnetic field of several tesla, which is generated by a superconducting coil field by a current source. This document describes the current source control as well as the high precision ammeters control. These ammeters measure the current in the superconducting coils. The user interface and the programming of the control system are described. The communication between devices is also explained. (author) 9 Refs

  11. Status of the 2 MW, 170 GHz coaxial cavity gyrotron for ITER

    International Nuclear Information System (INIS)

    Full text: A 170 GHz coaxial cavity gyrotron with 2 MW output power in continuous wave (CW) operation is under development in cooperation between European research centres together with European industry. A first industrial prototype of such a gyrotron has already been fabricated and delivered to CRPP Lausanne, where a suitable test facility has been constructed. Due to a delay in fabrication the delivery of the gyrotron magnet is expected in May 2007. Thus experimental tests are expected for the second half of this year. In parallel to the industrial activities, experimental operation with a short pulse (∼ few ms) 170 GHz coaxial gyrotron ('pre-prototype') which uses the same main components as designed for the industrial tube has been continued. The mechanism of parasitic low frequency (LF) oscillations around 260 MHz has been identified. Based on this identification, small modifications of the geometry of the coaxial insert have been made. As a result the starting current for the LF oscillations has been increased by a factor of about 3 causing a strong reduction of the LF amplitude. Measurements with a prototype of a microwave load, which has been designed and fabricated for operation with the 2 MW prototype tube, have been performed. In addition to the distribution of the microwave power absorbed on the wall, the amount of power reflected back into the gyrotron has been measured and its influence on gyrotron performance has been investigated. The performance of the quasi optical (q.o.) RF output system presently installed in the industrial prototype tube is insufficient, mainly because of the low Gaussian content of the RF output beam. As a first step a new launcher with a different wall corrugation and a new adapted phase correcting mirror has been designed and fabricated. According to simulations an increase of the Gaussian content to about 87% is expected. This q.o. RF output system has been installed in the pre-prototype tube for performing hot

  12. Stable, high efficiency gyrotron backward-wave oscillator

    Science.gov (United States)

    Fan, C. T.; Chang, T. H.; Pao, K. F.; Chu, K. R.; Chen, S. H.

    2007-09-01

    Stability issues have been a major concern for the realization of broadband tunability of the gyrotron backward-wave oscillator (gyro-BWO). Multimode, time-dependent simulations are employed to examine the stability properties of the gyro-BWO. It is shown that the gyro-BWO is susceptible to both nonstationary oscillations and axial mode competition in the course of frequency tuning. Regions of nonstationary oscillations and axial mode competition are displayed in the form of stability maps over wide-ranging parameter spaces. These maps serve as a guide for the identification and optimization of stable windows for broadband tuning. Results indicate that a shorter interaction length provides greater stability without efficiency degradation. These theoretical predictions have been verified in a Ka-band gyro-BWO experiment using both short and long interaction lengths. In the case of a short interaction length, continuous and smooth tunability, in magnetic field and in beam voltage, was demonstrated with the high interaction efficiency reported so far. A maximum 3-dB tuning range of 1.3GHz with a peak power of 149kW at 29.8% efficiency was achieved. In a comparative experiment with a longer interaction length, the experimental data are characterized by piecewise-stable tuning curves separated by region(s) of nonstationary oscillations, as predicted by theory.

  13. Commissioning a Megawatt-class Gyrotron with Collector Potential Depression

    Science.gov (United States)

    Lohr, J.; Cengher, M.; Gorelov, Y. A.; Ponce, D.; Prater, R.

    2013-10-01

    A 110 GHz depressed collector gyrotron has been installed on the DIII-D tokamak. The commissioning process rapidly achieved operation at full parameters, 45 A and 94 kV total voltage, with 29 kV depression. Although short pulse, 2 ms, factory testing demonstrated 1.2 MW at 41% electrical efficiency, long pulse testing at DIII-D achieved only 33% efficiency at full power parameters, for pulse lengths up to 10 s. Maximum generated power was ~950 kW, considerably below the 1.2 MW target. During attempts to increase the power at 5 s pulse length, it was noted that the collector cooling water was boiling. This led to the discovery that 14 of the 160 cooling channels in the collector had been blocked by braze material during manufacture of the tube. The locations of blocked channels were identified using infrared imaging of the outside of the collector during rapid changes in the cooling water temperature. Despite these difficulties, the rf beam itself was of very high quality and the stray rf found calorimetrically in the Matching Optics Unit, which couples the Gaussian rf beam to the waveguide, was only 2% of the generated power, about half that of our previous best quality high power beam. Details of the power measurements and collector observations will be presented. Work supported by the US DOE under DE-FC02-04ER54698.

  14. Paramagnet induced signal quenching in MAS-DNP experiments in frozen homogeneous solutions

    Science.gov (United States)

    Corzilius, Björn; Andreas, Loren B.; Smith, Albert A.; Ni, Qing Zhe; Griffin, Robert G.

    2014-03-01

    The effects of nuclear signal quenching induced by the presence of a paramagnetic polarizing agent are documented for conditions used in magic angle spinning (MAS)-dynamic nuclear polarization (DNP) experiments on homogeneous solutions. In particular, we present a detailed analysis of three time constants: (1) the longitudinal build-up time constant TB for 1H; (2) the rotating frame relaxation time constant T1ρ for 1H and 13C and (3) T2 of 13C, the transverse relaxation time constant in the laboratory frame. These relaxation times were measured during microwave irradiation at a magnetic field of 5 T (140 GHz) as a function of the concentration of four polarizing agents: TOTAPOL, 4-amino-TEMPO, trityl (OX063), and Gd-DOTA and are compared to those obtained for a sample lacking paramagnetic doping. We also report the EPR relaxation time constants T1S and T2S, the DNP enhancements, ε, and the parameter E, defined below, which measures the sensitivity enhancement for the four polarizing agents as a function of the electron concentration. We observe substantial intensity losses (paramagnetic quenching) with all of the polarizing agents due to broadening mechanisms and cross relaxation during MAS. In particular, the monoradical trityl and biradical TOTAPOL induce ∼40% and 50% loss of signal intensity. In contrast there is little suppression of signal intensity in static samples containing these paramagnetic species. Despite the losses due to quenching, we find that all of the polarizing agents provide substantial gains in signal intensity with DNP, and in particular that the net enhancement is optimal for biradicals that operate with the cross effect. We discuss the possibility that much of this polarization loss can be regained with the development of instrumentation and methods to perform electron decoupling.

  15. Design and operation of 140 GHz gyrotron oscillators for power levels up to 1 MW CW

    Energy Technology Data Exchange (ETDEWEB)

    Jory, H.; Bier, R.; Craig, L.J.; Felch, K.; Ives, L.; Lopez, N.; Spang, S.

    1986-12-01

    Varian has designed and tested 140 GHz gyrotron oscillators that have generated output powers of 100 kW CW and 200 kW for 1 ms pulses. Upcoming tubes will be designed to operate at power levels of 200 kW CW and ultimately up to 1 MW CW. The important design considerations which are addressed in the higher power tubes include the design of the electron gun, interaction circuit, and output window. These issues will be discussed and the results of the earlier 140 GHz gyrotron work at Varian will be summarized.

  16. Infrared measurements of the synthetic diamond window of a 110 GHz high power Gyrotron

    International Nuclear Information System (INIS)

    Artificially grown diamond has extremely low absorption for microwaves in the millimeter wave range, making this material an attractive candidate for output windows on high power gyrotrons. Several windows have failed in this application due to higher than expected losses. Infrared measurements of the window temperature on a high power gyrotron operating at 110 GHz have been performed. The peak central temperature and time to equilibrium during the rf pulse were consistent with the low loss properties of the material determined from low power cavity measurements

  17. Design of 95 GHz, 2 MW Gyrotron for Communication and Security Applications

    Science.gov (United States)

    Kumar, Nitin; Singh, Udaybir; Singh, T. P.; Sinha, A. K.

    2011-02-01

    The design and the numerical simulation of the 95 GHz, 2 MW gyrotron for various kinds of communication, sensing and security applications is presented. The gyrotron is designed for the TE24,8 operating mode. Various in-house developed and commercially available computer codes are used for the design purpose. A 4.25 MW electron gun is designed for the 2 MW of output power. The mode selection, cold cavity and the beam-wave interaction analysis are discussed for the design of weakly tapered open resonator type of interaction cavity. The parametric analysis of the interaction cavity and the electron gun is also presented.

  18. Effects of INH, DNP, 2,4-D and CMU on the photosynthetic activity of barley and maize plants

    International Nuclear Information System (INIS)

    Determinations of the rate of photosynthesis were made in barley and maize leaves treated with INH, DNP, 2,4-D or CMU. 1 ppm of the chemicals in nutritive solutions was absorbed by roots during 24 or 48 hours in both dark and light conditions. After this period, photosynthetic activity, compensation point and 14CO2 assimilation were determined. Results show that INH increases the rate of photosynthesis, DNP and 2,4-D do not alter it sensibly and CMU acts as a strong inhibitor of photosynthesis. Some possible applications for ths obtention of labelled compounds by biosynthesis are discussed. (Author) 87 refs

  19. Continuous-Wave Operation of a Frequency-Tunable 460-GHz Second-Harmonic Gyrotron for Enhanced Nuclear Magnetic Resonance

    OpenAIRE

    Torrezan, Antonio C.; Han, Seong-Tae; Mastovsky, Ivan; Shapiro, Michael A; Sirigiri, Jagadishwar R.; Temkin, Richard J.; Griffin, Robert G.; Barnes, Alexander B.

    2010-01-01

    The design, operation, and characterization of a continuous-wave (CW) tunable second-harmonic 460-GHz gyrotron are reported. The gyrotron is intended to be used as a submillimeter-wave source for 700-MHz nuclear magnetic resonance experiments with sensitivity enhanced by dynamic nuclear polarization. The gyrotron operates in the whispering-gallery mode TE11,2 and has generated 16 W of output power with a 13-kV 100-mA electron beam. The start oscillation current measured over a range of magnet...

  20. Measurement of Radiation Frequency of Gyrotron by GaAs Schottky Barrier Diodes Coupled with Thin-Film Slot Antenna

    Science.gov (United States)

    Kosuke Hayashi,; Takashi Furuya,; Takashi Tachiki,; Takashi Uchida,; Toshitaka Idehara,; Yoshizumi Yasuoka,

    2010-03-01

    Thin-film slot-antenna-coupled GaAs Schottky barrier diodes (SBDs) used at the 180 GHz band were fabricated by microfabrication techniques, and the radiation frequency of a gyrotron at the University of Fukui (Gyrotron FU CW IV) was measured. In second-harmonic mixing using a local oscillator (LO) wave of 88.0899 GHz, an intermediate frequency (IF) signal of 102.8 MHz was observed and the radiation frequency of the gyrotron was found to be 176.077 GHz.

  1. A Fully-Sealed Carbon-Nanotube Cold-Cathode Terahertz Gyrotron

    Science.gov (United States)

    Yuan, Xuesong; Zhu, Weiwei; Zhang, Yu; Xu, Ningsheng; Yan, Yang; Wu, Jianqiang; Shen, Yan; Chen, Jun; She, Juncong; Deng, Shaozhi

    2016-09-01

    Gigahertz to terahertz radiation sources based on cold-cathode vacuum electron technology are pursued, because its unique characteristics of instant switch-on and power saving are important to military and space applications. Gigahertz gyrotron was reported using carbon nanotube (CNT) cold-cathode. It is reported here in first time that a fully-sealed CNT cold-cathode 0.22 THz-gyrotron is realized, typically with output power of 500 mW. To achieve this, we have studied mechanisms responsible for CNTs growth on curved shape metal surface, field emission from the sidewall of a CNT, and crystallized interface junction between CNT and substrate material. We have obtained uniform growth of CNTs on and direct growth from cone-cylinder stainless-steel electrode surface, and field emission from both tips and sidewalls of CNTs. It is essential for the success of a CNT terahertz gyrotron to have such high quality, high emitting performance CNTs. Also, we have developed a magnetic injection electron gun using CNT cold-cathode to exploit the advantages of such a conventional gun design, so that a large area emitting surface is utilized to deliver large current for electron beam. The results indicate that higher output power and higher radiation frequency terahertz gyrotron may be made using CNT cold-cathode electron gun.

  2. Start-Up Scenario in Gyrotrons with a Nonstationary Microwave-Field Structure

    Science.gov (United States)

    Nusinovich, G. S.; Yeddulla, M.; Antonsen, T. M., Jr.; Vlasov, A. N.

    2006-03-01

    Megawatt class gyrotrons operate in very high-order modes. Therefore, control of a gyrotron oscillator’s start-up is important for excitation of the desired mode in the presence of the many undesired modes. Analysis of such scenario using the self-consistent code MAGY [M. Botton , IEEE Trans. Plasma Sci. 26,ITPSBD0093-3813 882 (1998)10.1109/27.700860] reveals that during start-up not only mode amplitudes vary in time, but also their axial structure can be time dependent. Simulations done for a 1.5 MW gyrotron show that the excitation of a single operating TE22,6 mode can exhibit a sort of intermittency when, first, it is excited as a mode whose axial structure extends outside the interaction cavity, then it ceases and then reappears as a mode mostly localized in the cavity. This phenomenon makes it necessary to analyze start-up scenarios in such gyrotrons with the use of codes that account for the possible evolution of field profiles.

  3. CONDITIONING AND PROTECTION CIRCUITRY FOR EXTERNAL MODULATION OF A PREPROGRAMMED GYROTRON CATHODE VOLTAGE COMMAND WAVEFORM

    Energy Technology Data Exchange (ETDEWEB)

    PONCE,D; FERRON,J.R; LEGG,R.A

    2003-10-01

    OAK-B135 The modulating voltages applied to the DIII-D gyrotrons are controlled by reference signals which are synthesized by arbitrary waveform generators.These generators allow ECH operators to pre-program reference waveforms consisting of ramps, flat tops, and various modulation shapes. This capability is independent of the DIII-D central timing and waveform facilities, which provides the ECH operators operational flexibility. The waveform generators include an amplitude modulation input, providing a means to control the pre-programmed waveform externally. This input is being used to allow the DIII-D plasma control system (PCS) to control gyrotron power in response top selected feedback signals. As the PCS control signal could potentially modulate the gyrotrons beyond operational limits or otherwise in a manner leading to recalcitrant rf generation, the control signal is conditioned so that its effect upon the ECH pre-programmed reference waveform is limited by conditions set by the ECH operators. The design of the circuitry which restricts the range over which the PCS control signal may modulate the reference waveform will be discussed. Test and DIII-D experimental results demonstrating the utility and effectiveness of gyrotron power modulated by the PCS will be presented.

  4. Simulation tools for computer-aided design and numerical investigations of high-power gyrotrons

    Science.gov (United States)

    Damyanova, M.; Balabanova, E.; Kern, S.; Illy, S.; Sabchevski, S.; Thumm, M.; Vasileva, E.; Zhelyazkov, I.

    2012-03-01

    Modelling and simulation are essential tools for computer-aided design (CAD), analysis and optimization of high-power gyrotrons used as radiation sources for electron cyclotron resonance heating (ECRH) and current drive (ECCD) of magnetically confined plasmas in the thermonuclear reactor ITER. In this communication, we present the current status of our simulation tools and discuss their further development.

  5. To the theory of high-power gyrotrons with uptapered resonators

    International Nuclear Information System (INIS)

    In high-power gyrotrons it is desirable to combine an optimal resonator length with the optimal value of the resonator quality factor. In resonators with the constant radius of the central part, the possibilities of this combination are limited because the quality factor of the resonator sharply increases with its length. Therefore the attempts to increase the length for maximizing the efficiency leads to such increase in the quality factor which makes the optimal current too small. Resonators with slightly uptapered profiles offer more flexibility in this regard. In such resonators, one can separate optimization of the interaction length from optimization of the quality factor because the quality factor determined by diffractive losses can be reduced by increasing the angle of uptapering. In the present paper, these issues are analyzed by studying as a typical high-power 17 GHz gyrotron which is currently under development in Europe for ITER (http://en.wikipedia.org/wiki/ITER). The effect of a slight uptapering of the resonator wall on the efficiency enhancement and the purity of the radiation spectrum in the process of the gyrotron start-up and power modulation are studied. Results show that optimal modification of the shape of a slightly uptapered resonator may result in increasing the gyrotron power from 1052 to 1360 kW.

  6. A Fully-Sealed Carbon-Nanotube Cold-Cathode Terahertz Gyrotron.

    Science.gov (United States)

    Yuan, Xuesong; Zhu, Weiwei; Zhang, Yu; Xu, Ningsheng; Yan, Yang; Wu, Jianqiang; Shen, Yan; Chen, Jun; She, Juncong; Deng, Shaozhi

    2016-01-01

    Gigahertz to terahertz radiation sources based on cold-cathode vacuum electron technology are pursued, because its unique characteristics of instant switch-on and power saving are important to military and space applications. Gigahertz gyrotron was reported using carbon nanotube (CNT) cold-cathode. It is reported here in first time that a fully-sealed CNT cold-cathode 0.22 THz-gyrotron is realized, typically with output power of 500 mW. To achieve this, we have studied mechanisms responsible for CNTs growth on curved shape metal surface, field emission from the sidewall of a CNT, and crystallized interface junction between CNT and substrate material. We have obtained uniform growth of CNTs on and direct growth from cone-cylinder stainless-steel electrode surface, and field emission from both tips and sidewalls of CNTs. It is essential for the success of a CNT terahertz gyrotron to have such high quality, high emitting performance CNTs. Also, we have developed a magnetic injection electron gun using CNT cold-cathode to exploit the advantages of such a conventional gun design, so that a large area emitting surface is utilized to deliver large current for electron beam. The results indicate that higher output power and higher radiation frequency terahertz gyrotron may be made using CNT cold-cathode electron gun. PMID:27609247

  7. State-of-the-art and recent developments of high-power gyrotron oscillators

    Science.gov (United States)

    Thumm, Manfred

    1999-05-01

    Gyrotron oscillators (gyromonotrons) are mainly used as high-power millimeter wave sources for electron cyclotron resonance heating (ECRH) and diagnostics of magnetically confined plasmas for generation of energy by controlled thermonuclear fusion. High unit power and high efficiency single-mode CW gyrotrons with conventional cylindrical (1 MW) and advanced coaxial (2 MW) cavities are worldwide under development. 118 GHz, 140 GHz and 170 GHz conventional cavity gyrotrons with output power Pout≈0.5 MW, pulse length τ≈5.0 s and efficiency η≈35% are commercially available. Advanced internal quasi-optical mode converters generate linearly polarized output wave beams from the high-order cavity modes (e.g., TE22,6) with efficiencies of 90-95% and separate the millimeter-wave beam from the electron beam, thus allowing the use of large CW-relevant depressed collectors for energy recovery. Overall efficiencies between 50 and 60% have been already achieved at JAERI, FZK, and GYCOM employing single-stage depressed collectors (SDC). First successful experiments at FZK employing a broadband Brewster window gave up to 1.5 MW output power at around 50% efficiency (SDC) for all operating mode series in the frequency range from 114 to 166 GHz (frequency tuning in 3.7 GHz steps by variation of the magnetic field strength in the cavity). Gyrotrons with advanced coaxial cavities designed for operation in the TE28,16 and TE31,17 modes at 140 and 165 GHz, respectively, are under development and test at IAP Nizhny Novgorod and FZK Karlsruhe. A maximum output power of 1.7 MW has been measured at 165 GHz with an efficiency of 35.2% (SDC, FZK). Cryogenically edge-cooled single-disk sapphire (T=77 K) and Au-doped silicon (T=230 K) windows as well as CVD-diamond windows with water edge-cooling at room temperature are under investigation in order to solve the window problem. Commercial CVD-diamond disks will easily allow the transmission of 2 MW power level at 170 GHz, CW. Bonding and

  8. State-of-the-art and recent developments of high-power gyrotron oscillators

    International Nuclear Information System (INIS)

    Gyrotron oscillators (gyromonotrons) are mainly used as high-power millimeter wave sources for electron cyclotron resonance heating (ECRH) and diagnostics of magnetically confined plasmas for generation of energy by controlled thermonuclear fusion. High unit power and high efficiency single-mode CW gyrotrons with conventional cylindrical (1 MW) and advanced coaxial (2 MW) cavities are worldwide under development. 118 GHz, 140 GHz and 170 GHz conventional cavity gyrotrons with output power Pout≅0.5 MW, pulse length τ≅5.0 s and efficiency η≅35% are commercially available. Advanced internal quasi-optical mode converters generate linearly polarized output wave beams from the high-order cavity modes (e.g., TE22,6) with efficiencies of 90-95% and separate the millimeter-wave beam from the electron beam, thus allowing the use of large CW-relevant depressed collectors for energy recovery. Overall efficiencies between 50 and 60% have been already achieved at JAERI, FZK, and GYCOM employing single-stage depressed collectors (SDC). First successful experiments at FZK employing a broadband Brewster window gave up to 1.5 MW output power at around 50% efficiency (SDC) for all operating mode series in the frequency range from 114 to 166 GHz (frequency tuning in 3.7 GHz steps by variation of the magnetic field strength in the cavity). Gyrotrons with advanced coaxial cavities designed for operation in the TE28,16 and TE31,17 modes at 140 and 165 GHz, respectively, are under development and test at IAP Nizhny Novgorod and FZK Karlsruhe. A maximum output power of 1.7 MW has been measured at 165 GHz with an efficiency of 35.2% (SDC, FZK). Cryogenically edge-cooled single-disk sapphire (T=77 K) and Au-doped silicon (T=230 K) windows as well as CVD-diamond windows with water edge-cooling at room temperature are under investigation in order to solve the window problem. Commercial CVD-diamond disks will easily allow the transmission of 2 MW power level at 170 GHz, CW. Bonding and

  9. Installation and operation of the 400 kW 140 GHz gyrotron on the MTX experiment

    International Nuclear Information System (INIS)

    This paper describes the installation and operation of the 400 kW 140 GHz gyrotron used for plasma heating on the Microwave Tokamak Experiment (MTX) at Lawrence Livermore National Laboratory (LLNL). The Varian VGT-8140 gyrotron has operated at a power level of 400 kW for 100 ms in conjunction with MTX plasma shots. The gyrotron system is comprised of a high voltage (-80 kV) modulated power supply, a multistation CAMAC computer control, a 5-tesla superconducting magnet, a series of conventional copper magnets, a circulating fluorinert (FC75) window cooling system, a circulating oil cooling system, a water cooling system, and microwave frequency and power diagnostics. Additionally, a Vlasov launcher is used to convert the gyrotron TE 15,2 mode to a Gaussian beam. Two versions of the Vlasov launcher have been used on the gyrotron, one version designed by LLNL and one version designed by the Japan Atomic Energy Research Institute (JAERI). The Gaussian beam from the Vlasov launcher is transported to the MTX tokamak by a series of 5 mirrors in a 35-meter-long, high-efficiency, quasioptical beam transport system. A twist polarizer is built into one of the mirrors to adjust for horizontal polarization in the tokamak. No windows are used between the Vlasov reflector and the MTX tokamak. A laser alignment system is used to perform the initial system alignment. A summary of the design and operating characteristics of each of these systems is included. Also included is a summary of the system operation and performance

  10. 1 MW and long pulse operation of Gaussian beam output gyrotron with CVD diamond window for fusion devices

    International Nuclear Information System (INIS)

    A 110 GHz-Gaussian beam output gyrotron with chemical vapor deposition (CVD) diamond window was developed for electron cyclotron heating and current drive on JT-60U. A stable Gaussian output beam power of 1.0 MW for 2 s was obtained with depressed collector operation. The temperature at the center of the diamond window was stabilized at the ΔT∼25 K. Gaussian beam output from the gyrotron remarkably improved the coupling efficiency to the HE11 mode in the transmission waveguide. 94% of the gyrotron output power was coupled to the corrugated waveguide of 31.75 mm in diameter, via a matching optics unit with two mirrors. A combination of the Gaussian output and the diamond window are indispensable for high power gyrotron operation at more than 1 MW and efficient coupling to the transmission line

  11. [Effects of Celosia argentea and Cucurbita moschata extracts on anti-DNP IgE antibody production in mice].

    Science.gov (United States)

    Imaoka, K; Ushijima, H; Inouye, S; Takahashi, T; Kojima, Y

    1994-05-01

    We have already reported that the Perilla frutescens extract (PFE) suppressed anti-DNA IgE antibody production in mice. In this study, we prepared extracts of Celosia argentea L. (CAE) and Cucurbita moschata Duch (CME), which are Chinese herbal medicines like Perilla frutescens, and examined the effects on anti-DNP antibody responses in mice. To examine the effects of CAE & CME on primary antibody responses, CAE & CME were intraperitoneally injected the day before primary immunization of DNP-ovalbumin. Anti-DNP antibody production was markedly suppressed. Then, we examined the effects on secondary antibody responses. CEA & CME were injected only the day before secondary immunization. Anti-DNP IgE production was markedly suppressed, but IgG responses were not affected. It was also found that mitogenic activity occurred in CAE & CME dose dependently in vitro. These effects of CAE & CME were superior to that of PFE. These results suggest that CAE & CME may be more useful than PFE for the suppression of IgE antibody in certain allergic disorders.

  12. Insight into the Supramolecular Architecture of Intact Diatom Biosilica from DNP-Supported Solid-State NMR Spectroscopy

    NARCIS (Netherlands)

    Jantschke, Anne; Koers, Eline; Mance, Deni; Weingarth, Markus; Brunner, Eike; Baldus, Marc

    2015-01-01

    Diatom biosilica is an inorganic/organic hybrid with interesting properties. The molecular architecture of the organic material at the atomic and nanometer scale has so far remained unknown, in particular for intact biosilica. A DNP-supported ssNMR approach assisted by microscopy, MS, and MD simulat

  13. Dynamic Nuclear Polarization (DNP) solid-state NMR spectroscopy, a new approach to study humic material?

    Science.gov (United States)

    Knicker, Heike; Lange, Sascha; van Rossum, Barth; Oschkinat, Hartmut

    2016-04-01

    Compared to solution NMR spectroscopy, solid-state NMR spectra suffer from broad resonance lines and low resolution. This could be overcome by the use of 2-dimenstional solid-state NMR pulse sequences. Until recently, this approach has been unfeasible as a routine tool in soil chemistry, mainly because of the low NMR sensitivity of the respective samples. A possibility to circumvent those sensitivity problems represents high-field Dynamic Nuclear Polarization (DNP) solid-state NMR spectroscopy (Barnes et al., 2008), allowing considerable signal enhancements (Akbey et al., 2010). This is achieved by a microwave-driven transfer of polarization from a paramagnetic center to nuclear spins. Application of DNP to MAS spectra of biological systems (frozen solutions) showed enhancements of the factor 40 to 50 (Hall et al., 1997). Enhancements of this magnitude, thus may enable the use of at least some of the 2D solid-state NMR techniques that are presently already applied for pure proteins but are difficult to apply to soil peptides in their complex matrix. After adjusting the required acquisition parameters to the system "soil organic matter", lower but still promising enhancement factors were achieved. Additional optimization was performed and allowed the acquisition of 2D 13C and 15N solid-state NMR spectra of humified 13C and 15N enriched plant residues. Within the present contribution, the first solid-state DNP NMR spectra of humic material are presented. Those data demonstrate the great potential of this approach which certainly opens new doors for a better understanding of biochemical processes in soils, sediments and water. Akbey, Ü., Franks, W.T., Linden, A., Lange, S., Griffin, R.G., van Rossum, B.-J., Oschkinat, H., 2010. Dynamic nuclear polarization of deuterated proteins. Angewandte Chemie International Edition 49, 7803-7806. Barnes, A.B., De Paëpe, G., van der Wel, P.C.A., Hu, K.N., Joo, C.G., Bajaj, V.S., Mak-Jurkauskas, M.L., Sirigiri, J.R., Herzfeld, J

  14. Effects of electron beam parameters and velocity spread on radio frequency output of a photonic band gap cavity gyrotron oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Ashutosh, E-mail: asingh.rs.ece@iitbhu.ac.in [Faculty of Physical Sciences, Institute of Natural Sciences and Humanities, Shri Ramswaroop Memorial University, Lucknow-Deva Road, Uttar Pradesh 225003 (India); Center of Research in Microwave Tubes, Department of Electronics Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005 (India); Jain, P. K. [Center of Research in Microwave Tubes, Department of Electronics Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005 (India)

    2015-09-15

    In this paper, the effects of electron beam parameters and velocity spread on the RF behavior of a metallic photonic band gap (PBG) cavity gyrotron operating at 35 GHz with TE{sub 041}–like mode have been theoretically demonstrated. PBG cavity is used here to achieve a single mode operation of the overmoded cavity. The nonlinear time-dependent multimode analysis has been used to observe the beam-wave interaction behavior of the PBG cavity gyrotron, and a commercially available PIC code “CST Particle Studio” has been reconfigured to obtain 3D simulation results in order to validate the analytical values. The output power for this typical PBG gyrotron has been obtained ∼108 kW with ∼15.5% efficiency in a well confined TE{sub 041}–like mode, while all other competing modes have significantly low values of power output. The output power and efficiency of a gyrotron depend highly on the electron beam parameters and velocity spread. The influence of several electron beam parameters, e.g., beam voltage, beam current, beam velocity pitch factor, and DC magnetic field, on the PBG gyrotron operations has been investigated. This study would be helpful in optimising the electron beam parameters and estimating accurate RF output power of the high frequency PBG cavity based gyrotron oscillators.

  15. Gyrotron: an application of the relativistic bunching of electrons to the generation of intense millimeter microwave radiation

    International Nuclear Information System (INIS)

    The cyclotron maser or gyrotron is capable of generating high power microwaves at millimeter wave frequencies for applications in fusion heating, radar astronomy and communications. Analytic and numerical simulation models are developed that describe the behavior of these devices under realistic laboratory conditions including the effects of circuit geometry, beam thermal spread, and mode competition. In Chapter 2, a generalized linear theory for the gyrotron is presented in the form of an integro-differential equation that can be solved within various circuit geometries thus describing gyro-amplifiers, gyro-oscillatory and gyroklystrons. In Chapter 3 a complete description of a finite size electromagnetic particle simulation model is presented that describes gyrotrons operating in a TE/sub mn/ waveguide mode. In Chapter 4 simulations and theoretical analysis are made of gyrotron amplifiers operating in the TE/sub 01/ mode. In Chapter 5 the linear eigenmodes and eigenfrequencies of gyrotron oscillators are examined. In Chapter 6 the experimental development of a GHz gyrotron is presented. Theoretical and numerical predictions of oscillation thresholds and efficiencies compare favorably with experimental data

  16. AN ANP/DNP ANALYSIS OF ECONOMIC ELEMENTS IN TODAY'S WORLD NETWORK ECONOMY

    Institute of Scientific and Technical Information of China (English)

    Petr FIALA

    2006-01-01

    The network economy is a term for today's global relationship among economic elements characterized by massive connectivity. The central act of the new era is to connect everything to everything in deep web networks at many levels of mutually interdependent relations, where resources and activities are shared, markets are enlarged and costs and risk are reduced. Network systems contain both positive and negative feedback. A variety of feedback processes create complex system behavior.For such a network the Analytic Network Process (ANP) approach seems to be very appropriate. The ANP method makes it possible to deal systematically with all kinds of dependence and feedback in the system. Dynamic models try to reflect changes in real or simulated time and take into account that the network model components are constantly evolving. Dynamic models use concepts of state variables,flows, and feedback processes. The Dynamic Network Process (DNP) is anextension of ANP that can deal with time dependent priorities in a networked economy.

  17. Comparison of Different Methods for Calculating Gyrotron Quasi-Optical Mode Converters

    Science.gov (United States)

    Gashturi, A. P.; Chirkov, A. V.; Denisov, G. G.; Paveliev, A. B.

    2013-01-01

    This paper presents the use of combination of three methods for calculation and synthesis of high-efficiency microwave mode converters, such as radiators of gyrotrons. The analytical method yields immediate estimates of mode converter dimensions, the Scalar Integral Equation (SIE) allows one to synthesize efficiently the optimal profile of the mode converter, and the most accurate Electric Field Integral Equation (EFIE) is used to check all transmission characteristics of the converter including calculations of reflection and cross-polarization. The combination of these three methods is an optimal for the mode converter design. Just so the launcher was designed for a quasi-optical mode converter used in the 60 GHz gyrotron in the TE7,3 operating mode. The simulation results agree well with the measured data. The paper also presents for the first time an accurate derivation of the SIE method.

  18. 140 GHz high-power gyrotron development for the stellarator W7-X

    International Nuclear Information System (INIS)

    Electron cyclotron resonance heating (ECRH) has proven to be one of the most attractive heating schemes for stellarators. Therefore, ECRH was chosen to be the main heating method for the Wendelstein 7-X stellarator (W7-X) now under construction at IPP Greifswald, Germany. A 10 MW ECRH system with continuous wave (CW) possibilities, operating at 140 GHz will be built up to meet the scientific goals of the stellarator. Two prototype gyrotrons with an output power of 1 MW were developed in collaboration between European research laboratories and European industry (Thales Electron Devices, France). The gyrotrons are equipped with a single-stage depressed collector, an optimised quasi-optical mode converter and a CVD-diamond window. The prototypes have been successfully tested at FZK. With the second one, an output power of 0.89 MW at a pulse duration of 3 min and an output power of 0.54 MW for about 15 min have been obtained

  19. Gyrotrons for High-Power Terahertz Science and Technology at FIR UF

    Science.gov (United States)

    Idehara, Toshitaka; Sabchevski, Svilen Petrov

    2016-10-01

    In this review paper, we present the recent progress in the development of a series of gyrotrons at the Research Center for Development of Far-Infrared Region, University of Fukui, that have opened the road to many novel applications in the high-power terahertz science and technology. The current status of the research in this actively developing field is illustrated by the most representative examples in which the developed gyrotrons are used as powerful and frequency-tunable sources of coherent radiation operating in a continuous-wave regime. Among them are high-precision spectroscopic techniques (most notably dynamic nuclear polarization-nuclear magnetic resonance, electron spin resonance, X-ray detected magnetic resonance, and studies of the hyperfine splitting of the energy levels of positronium), treatment and characterization of advanced materials, and new medical technologies.

  20. Problem-Oriented Simulation Packages and Computational Infrastructure for Numerical Studies of Powerful Gyrotrons

    Science.gov (United States)

    Damyanova, M.; Sabchevski, S.; Zhelyazkov, I.; Vasileva, E.; Balabanova, E.; Dankov, P.; Malinov, P.

    2016-05-01

    Powerful gyrotrons are necessary as sources of strong microwaves for electron cyclotron resonance heating (ECRH) and electron cyclotron current drive (ECCD) of magnetically confined plasmas in various reactors (most notably ITER) for controlled thermonuclear fusion. Adequate physical models and efficient problem-oriented software packages are essential tools for numerical studies, analysis, optimization and computer-aided design (CAD) of such high-performance gyrotrons operating in a CW mode and delivering output power of the order of 1-2 MW. In this report we present the current status of our simulation tools (physical models, numerical codes, pre- and post-processing programs, etc.) as well as the computational infrastructure on which they are being developed, maintained and executed.

  1. Development and simulation of RF components for high power millimeter wave gyrotrons

    International Nuclear Information System (INIS)

    To test gyrotron RF components, efficient low-power generators for rotating high-order modes of high purity are necessary. Designs of generators for the TE15,3 mode at 84 GHz and for the TE31,8 mode at 168 GHz are presented and some preliminary test results are discussed. In addition, Toshiba gyrotron cavities at 168 GHz were analyzed for leakage of RF power in the beam tunnel. To decrease RF power leakage, the declination angle of the cut-off cavity cross section has to be decreased. A TE15,3 waveguide nonlinear uptaper is analyzed at 84 GHz as well as 168 GHz uptapers. Since the calculated conversion losses are slightly higher than designed value, an optimization of those uptapers may be required. (author)

  2. High-frequency gyrotrons and their application to tokamak plasma heating

    International Nuclear Information System (INIS)

    A comprehensive analysis of high frequency (100 to 200 GHz) and high power (> 100 kW) gyrotrons has been conducted. It is shown that high frequencies will be required in order for electron cyclotron radiation to propagate to the center of a compact tokamak power reactor. High power levels will be needed in order to ignite the plasma with a reasonable number of gyrotron units. In the first part of this research, a set of analytic expressions, valid for all TE cavity modes and all harmonics, is derived for the starting current and frequency detuning using the Vlasov-Maxwell equations in the weakly relativistic limit. The use of an optical cavity is also investigated

  3. Preparation and LSC Standardization of ''89Sr (DNP) Using the CIEMAT/NIST Method; Preparacion del ''89Sr(DNP) y calibracion por centelleo liquido, mediante el metodo CIEMAT/NIST

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez Barquero, L.; Los Arcos Merino, J. M.; Grau Malonda, A.

    1994-07-01

    A procedure for preparation of liquid scintillation counting samples of the strontium DNP complex, labelled with ''89Sr, is described, the chemical quench, the counting stability and spectral evolution of this compound is studied in six scintillators, Toluene, Toluene-alcohol, Dioxane-naphthalene, HiSafe II, Ultima- Gold and Instagel. The liquid scintillation standardization of 89Sr-DNP by the CIEMAT/NIST method, using HiSafe II and Ultima-Gold scintillators, has been carried out. The discrepancies between experimental and computed efficiencies are lower than 0.38% and 0.48%, respectively. The solution has been standardized in terms of activity concentration to an overall uncertainty of 0,38%. (Author) 10 refs.

  4. Time-domain theory of gyrotron traveling wave amplifiers operating at grazing incidence

    International Nuclear Information System (INIS)

    Time-domain theory of the gyrotron traveling wave tube (gyro-TWT) operating at grazing incidence has been developed. The theory is based on a description of wave propagation by a parabolic equation. The results of the simulations are compared with experimental results of the observation of subnanosecond pulse amplification in a gyro-TWT consisting of three gain sections separated by severs. The theory developed can also be used successfully for a description of amplification of monochromatic signals

  5. Time domain analysis of a gyrotron traveling wave amplifier with misaligned electron beam

    International Nuclear Information System (INIS)

    This article develops a time-domain theory to study the beam-wave interaction in gyrotron traveling wave amplifier (gyro-TWA) with a misaligned electron beam. The effects of beam misalignment on the TE01 mode gyro-TWA operating at the fundamental are discussed. Numerical results show that the effect of misalignment is less obvious when the input power is larger, and the influences of misalignment on the stable gain and the stable time are basically opposite

  6. Progress on the Development of High Power Long Pulse Gyrotron and Related Technologies

    International Nuclear Information System (INIS)

    Full text: In the development of a higher power dual-frequency gyrotron, a high order mode gyrotron, which permits to select the oscillation at 170 GHz or 137 GHz, has been fabricated and tested. Short pulse experiments (0.5 ms) were performed with 1.3 MW power output at more than 30% of the oscillation efficiency for both frequencies. In long pulse experiments, 760 kW/46%/60 s at 170 GHz and 540 kW/42%/20 s at 137 GHz are achieved. It is the first time long pulse experiments with the dual-frequency gyrotron/triode electron gun. Since the RF beam direction from the output window is designed to be almost the same for both frequencies, good power couplings to the transmission line, which are 96% for 170 GHz and 94% for 137 GHz, are obtained by using a pair of identical phase correcting mirrors. Pulse extension is underway aiming for > 1 MW at CW operation. A 5 kHz full power modulation experiment was performed using the 170 GHz gyrotron of TE31,8 mode oscillation. The 5 kHz full power modulation was achieved with the full beam modulation by employing a fast voltage switching between the anode and cathode of the triode type electron gun. This satisfies the requirement of ITER. For further improvement, an advanced anode power supply system is proposed to reduce the oscillation period of adjacent mode at the start-up phase of each pulse. (author)

  7. Modelling and simulation of new generation powerful gyrotrons for the fusion research

    Energy Technology Data Exchange (ETDEWEB)

    Sabchevski, S [Institute of Electronics, Bulgarian Academy of Sciences, BG-1784 Sofia (Bulgaria); Zhelyazkov, I [Faculty of Physics, Sofia University, BG-1164 Sofia (Bulgaria)

    2007-04-15

    One of the important issues related with the cyclotron resonance heating (CRH) and current drive of fusion plasmas in thermonuclear reactors (tokamaks and stellarators) is the development of multi-megawatt class gyrotrons. There are generally three stages of the implementation of that task, notably (i) elaborating a novel generation of software tools for the physical modelling and simulation of such kind of gyrotrons, (ii) their computer aided design (CAD) and construction on the basis of the simulation's results, and finally, (iii) gyrotrons' testing in real experimental conditions. This tutorial paper concerns the first item-the development of software tools. In co-operation with the Institute for Pulsed Power and Microwave Technology at the Forschungszentrum Karlsruhe, Germany, and Centre de Recherches en Physique des Plasmas at Ecole Polytechnique Federale de Lausanne, Switzerland, we work on the conceptual design of the software tools under development. The basic conclusions are that the numerical codes for gyrotrons' modelling should possess the following essential characteristics: (a) portability, (b) extensibility, (c) to be oriented toward the solution of practical problems (i.e., elaborating of computer programs that can be used in the design process), (d) to be based on self-consistent 3D physical models, which take into account the departure from axial symmetry, and (e) ability to simulate time dependent processes (electrostatic PIC simulation) alongside with a trajectory analysis (ray tracing simulation). Here, we discuss how various existing numerical codes have to be improved and implemented via the advanced programming technologies for state-of-the-art computer systems including clusters, grid, parallel platforms, and supercomputers.

  8. Diffraction and Scattering in Launchers of Quasi-Optical Mode Converters for Gyrotrons

    OpenAIRE

    Flamm, Jens Hanspeter

    2012-01-01

    In this work different methods for the calculation of diffraction and scattering in launchers of quasi-optical mode converters for gyrotrons are compared, ranked and extended. The extension gives the opportunity to take a tapered average radius of the waveguide antenna into account. The comparison and the extension of the fast field calculation methods for component synthesis opens the possibility to reduce diffraction and stray radiation of reliable and powerful millimeter wave sources.

  9. Final Report for "Gyrotron Design and Evaluation using New Particle-in-Cell Capability"

    Energy Technology Data Exchange (ETDEWEB)

    David N Smithe

    2008-05-28

    ITER will depend on high power CW gyrotrons to deliver power to the plasma at ECR frequencies. However, gyrotrons can suffer from undesirable low frequency oscillations (LFO’s) which are known to interfere with the gun-region diagnostics and data collection, and are also expected to produce undesirable energy and velocity spread in the beam. The origins and processes leading to these oscillations are poorly understood, and existing gyrotron R&D tools, such as static gun solvers and interaction region models, are not designed to look at time-dependant oscillatory behavior. We have applied a time-domain particle-in-cell method to investigate the LFO phenomenon. Our company is at the forefront of smooth-curved-boundary treatment of the electromagnetic fields and particle emission surfaces, and such methods are necessary to simulate the adiabatically trapped and reflected electrons thought to be driving the oscillations. This approach provides the means for understanding, in microscopic detail, the underlying physical processes driving the low-frequency oscillations. In the Phase I project, an electron gun region from an existing gyrotron, known to observe LFO’s, was selected as a proof-of-principle geometry, and was modeled with the curved-geometry time-domain simulation tool, in order to establish the feasibility of simulating LFO physics with this tool on office-scale, and larger, parallel cluster computers. Generally, it was found to be feasible to model the simulation geometry, emission, and magnetic features of the electron gun. Ultimately, the tool will be used to investigate the origins and life cycle within the trapped particle population. This tool also provides the foundations and validation for potential application of the software to numerous other time-dependant beam and rf source problems in the commercial arena.

  10. Feasibility of ion temperature measurement with a gyrotron scattering alpha particle diagnostic

    International Nuclear Information System (INIS)

    Collective Thomson scattering can be used to diagnose localized ion temperature as well as alpha particle velocity distribution and density in a D-T burning tokamak. With one diagnostic beam a simultaneous, but independent, measure of the bulk ion temperature and alpha particle parameters can be made. Use of a long pulse, millimeter-wave gyrotron offers a significant margin in signal to noise ratio capability (√Δftau > 1000) not previously possible with lasers. 9 refs., 2 figs

  11. The Gyrotron: AN Application of the Relativistic Bunching of Electrons to the Generation of Intense Millimeter Microwave Radiation

    Science.gov (United States)

    Caplan, Malcolm

    The cyclotron maser or gyrotron is capable of generating high power microwaves at millimeter wave frequencies for applications in fusion heating, radar astronomy and communications. Analytic and numerical simulation models are developed which describe the behavior of these devices under realistic laboratory conditions including the effects of circuit geometry, beam thermal spread and mode competition. In Chapter 2, a generalized linear theory for the gyrotron is presented in the form of an integro-differential equation which can be solved within various circuit geometries thus describing gyro-amplifiers, gyro-oscillators and gyroklystrons. In Chapter 3 a complete description of a finite size electromagnetic particle simulation model is presented which describes gyrotrons operating in a TE(,mn) waveguide mode. The resulting computer code is a "stretched" version of a 1-3/2 D particle code which apart from modelling transient self-consistent wave beam dynamics includes the essential effects of arbitrary conducting boundaries without requiring a full 2D simulation. The code also allows simultaneous multi-mode interaction. In Chapter 4 simulations and theoretical analysis are made of gyrotron amplifiers operating in the TE(,01) mode to predict bandwidth gain and efficiency with particular attention to the stabilization of absolute instabilities through frequency selective loss. In Chapter 5 the linear eigenmodes and eigenfrequencies of gyrotron oscillators are examined including the effects of beam loading and circuit geometry. Oscillation threshold currents are obtained. The design analysis and predicted efficiencies of gyrotron oscillators operating in the TE(,021) mode with output powers of at least 200 kW are obtained from particle simulations. In Chapter 6 the experimental development of a GHz gyrotron is presented including the design of the magnetron injection gun, circuit, collector and window. Theoretical and numerical predictions of oscillation thresholds and

  12. Experimental Study Of A 1.5-mw, 110-ghz Gyrotron Oscillator

    CERN Document Server

    Anderson, J P

    2005-01-01

    This thesis reports the design, construction and testing of a 1.5 MW, 110 GHz gyrotron oscillator. This high power microwave tube has been proposed as the next evolutionary step for gyrotrons used to provide electron cyclotron heating required in fusion devices. A short pulse gyrotron based on the industrial tube design was built at MIT for experimental studies. The experiments are the first demonstration of such high powers at 110 GHz. Using a 96 kV, 40 A electron beam, over 1.4 MW was axially extracted in the design (TE22,6) mode in 3 μs pulses, corresponding to a microwave efficiency of 37%. The beam alpha, the ratio of transverse to axial velocity in the electron beam, was measured with a probe. At the high efficiency operating point the beam alpha was measured as 1.33. This value of alpha is less than the design value of 1.4, possibly accounting for the slightly reduced experimental efficiency. The output power and efficiency, as a function of magnetic field, beam voltage, and beam current, are in...

  13. Development of high power gyrotron and transmission line for ECH/ECCD system

    International Nuclear Information System (INIS)

    170 GHz, high power and long pulse gyrotron with CVD diamond output window (tanδ ≤ 1.4 x 10-4, σ = 1800 W/m/K) has successfully been developed. The operation of 0.45 MW-8.0 sec and of 0.52 MW-6.2 sec were performed. Temperature increase of the window center was 150 deg. C at the operation of 0.52 MW-6.2 sec, moreover, the increment saturated, which well agreed with the simulation result. No damage on the gyrotron window and the gyrotron itself was observed through the experiment. We have constructed the 40 m run transmission line to demonstrate the efficient transmission of high power and long pulse millimeter wave. The total transmission loss has been estimated as less than 18%, which includes the loss in mirror optical unit, assumed as 10%. The transmission efficiency, the mode purity and the polarization are mainly investigated in the high power transmission experiment. The diamond window assembly as tritium or vacuum barrier in a transmission line was fabricated for high pressure test. The disk was failed at pressure of 0.465 MPa, which is consistent with the material strength. (author)

  14. A 0.33-THz second-harmonic frequency-tunable gyrotron

    Science.gov (United States)

    Zheng-Di, Li; Chao-Hai, Du; Xiang-Bo, Qi; Li, Luo; Pu-Kun, Liu

    2016-02-01

    Dynamics of the axial mode transition process in a 0.33-THz second-harmonic gyrotron is investigated to reveal the physical mechanism of realizing broadband frequency tuning in an open cavity circuit. A new interaction mechanism about propagating waves, featured by wave competition and wave cooperation, is presented and provides a new insight into the beam-wave interaction. The two different features revealed in the two different operation regions of low-order axial modes (LOAMs) and high-order axial modes (HOAMs) respectively determine the characteristic of the overall performance of the device essentially. The device performance is obtained by the simulation based on the time-domain nonlinear theory and shows that using a 12-kV/150-mA electron beam and TE-3,4 mode, the second harmonic gyrotron can generate terahertz radiations with frequency-tuning ranges of about 0.85 GHz and 0.60 GHz via magnetic field and beam voltage tuning, respectively. Additionally, some non-stationary phenomena in the mode startup process are also analyzed. The investigation in this paper presents guidance for future developing high-performance frequency-tunable gyrotrons toward terahertz applications. Project supported by the National Natural Science Foundation of China (Grant Nos. 61471007, 61531002, 61522101, and 11275206) and the Seeding Grant for Medicine and Information Science of Peking University, China (Grant No. 2014-MI-01).

  15. Effects of INH, DNP, 2, 4-D and CMU on the sugar content of the barley and maize leaves

    International Nuclear Information System (INIS)

    1 ppm of the chemicals in nutritive solution was absorbed by barley and maize roots during 24 and 48 hours in dark or light conditioners in order to determine the best conditions for the obtention of labelled sugars with high specific activity. Results show that the highest specific activity was obtained in maize plants treated with DNP for 24 hours in dark conditions. (Author) 51 refs

  16. An apparatus for pulsed ESR and DNP experiments using optically excited triplet states down to liquid helium temperatures

    Science.gov (United States)

    Eichhorn, T. R.; Haag, M.; van den Brandt, B.; Hautle, P.; Wenckebach, W. Th.; Jannin, S.; van der Klink, J. J.; Comment, A.

    2013-09-01

    In standard Dynamic Nuclear Polarization (DNP) electron spins are polarized at low temperatures in a strong magnetic field and this polarization is transferred to the nuclear spins by means of a microwave field. To obtain high nuclear polarizations cryogenic equipment reaching temperatures of 1 K or below and superconducting magnets delivering several Tesla are required. This equipment strongly limits applications in nuclear and particle physics where beams of particles interact with the polarized nuclei, as well as in neutron scattering science. The problem can be solved using short-lived optically excited triplet states delivering the electron spin. The spin is polarized in the optical excitation process and both the cryogenic equipment and magnet can be simplified significantly. A versatile apparatus is described that allows to perform pulsed dynamic nuclear polarization experiments at X-band using short-lived optically excited triplet sates. The efficient 4He flow cryostat that cools the sample to temperatures between 4 K and 300 K has an optical access with a coupling stage for a fiber transporting the light from a dedicated laser system. It is further designed to be operated on a neutron beam. A combined pulse ESR/DNP spectrometer has been developed to observe and characterize the triplet states and to perform pulse DNP experiments. The ESR probe is based on a dielectric ring resonator of 7 mm inner diameter that can accommodate cubic samples of 5 mm length needed for neutron experiments. NMR measurements can be performed during DNP with a coil integrated in the cavity. With the presented apparatus a proton polarization of 0.5 has been achieved at 0.3 T.

  17. Crystal Structure and Thermal Decomposition Mechanism of [K(DNP)(H2O)0.5]n

    Institute of Scientific and Technical Information of China (English)

    MA, Gui-Xia(马桂霞); ZHANG, Tong-Lai(张同来); ZHANG, Jian-Guo(张建国); SHAO, Bing(邵兵); LI, Yu-Feng(李玉锋); SONG, Jiang-Chuang(宋江闯); YU, Kai-Bei(郁开北)

    2004-01-01

    The new coordination polymer, [K(DNP)(H2O)0.5]n (DNP=2,4-dinitrophenol) was prepared by the reaction of 2,4-dinitrophenol with potassium hydroxide. The molecular structure was determined by X-ray single-crystal diffraction analysis, FT-IR techniques, and elemental analysis. The crystal is monoclinic, space group C(2)/c with the empirical formula of C6H4N2O5.5K, Mr=231.21. The unit cell parameters are as follows: a=2.0789(3) nm, b=1.2311(2) nm, c=0.7203(1) nm, β=109.611(15)°, V=1.7366(4) nm3, Z=4, Dc=1.769 g/cm3, F(000)=936, μ (Mo Kα)=0.617 mm-1. The potassium ions coordinate with all the oxygen atoms of phenolic hydroxyl group and nitro-group of different 2,4-dinitrophenol (DNP) ligands with high coordination number, and form a good cross-linked three-dimensional net structure of which makes the complex with good stabilities. The thermal decomposition of [K(DNP)(H2O)0.5]n has only an intense exothermic process in the temperature range of 338-343 ℃ corresponding to a mass loss of 75.02%. The final decomposition residue is potassium isocyanide.

  18. Development and Applications of High—Frequency Gyrotrons in FIR FU Covering the sub-THz to THz Range

    Science.gov (United States)

    Idehara, Toshitaka; Sabchevski, Svilen Petrov

    2012-07-01

    Powerful sources of coherent radiation in the sub-terahertz and in the terahertz frequency range of the electromagnetic spectrum are necessary for a great and continuously expanding number of applications in the physical research and in various advanced technological processes as well as in radars, communication systems, for remote sensing and inspection etc.. In recent years, a spectacular progress in the development of various gyro-devices and in particular of the powerful high frequency (sub-terahertz and terahertz) gyrotron oscillators has demonstrated a remarkable potential for bridging the so-called terahertz power gap and stimulated many novel and prospective applications. In this review paper we outline two series of such devices, namely the Gyrotron FU Series which includes pulsed gyrotrons and Gyrotron FU CW Series which consist of tubes operated in a CW (continuous wave) or long pulse mode, both developed at the FIR FU Center. We present the most remarkable achievements of these devices and illustrate their applications by some characteristic examples. An outlook for the further extension of the Gyrotron FU CW Series is also provided.

  19. Experimental Research on a 1.5 MW, 110 GHz Gyrotron with a Smooth Mirror Internal Mode Converter

    Science.gov (United States)

    Tax, D. S.; Mastovsky, I.; Shapiro, M. A.; Temkin, R. J.; Torrezan, A. C.

    2010-11-01

    Megawatt gyrotrons are important for electron cyclotron heating (ECH) of fusion plasmas, including ITER. These gyrotrons should operate with high efficiency to reduce the prime power required and to ensure good reliability. The gyrotron efficiency is affected both by the physical principles that govern the device and the performance of components like the internal mode converter (IMC), which must convert the electromagnetic cavity mode into a Gaussian beam. An IMC consisting of a helically-cut launcher and three smooth curved mirrors, which is less susceptible to alignment errors than an IMC using mirrors with phase correcting surfaces, was recently tested on a 1.5 MW, 110 GHz, 3μs pulsed gyrotron operating in the TE22,6 mode, and an output beam with 95.8 ± 0.5 % Gaussian beam content was measured in both hot and cold tests. We are also examining the issue of mode competition in the gyrotron, which can limit the achievable output power and efficiency. The sequence of competing modes excited during the rise time of the voltage pulse has been measured and results are compared with the numerical simulation code MAGY. These results should provide a good test of the accuracy of the code.

  20. On the dependence of the efficiency of a 240 GHz high-power gyrotron on the displacement of the electron beam and on the azimuthal index

    Energy Technology Data Exchange (ETDEWEB)

    Dumbrajs, O. [Institute of Solid State Physics (ISSP), Association EUROATOM-University of Latvia, Kengaraga iela 8, LV-1063 Riga (Latvia); Avramidis, K. A.; Franck, J.; Jelonnek, J. [Karlsruhe Institute of Technology (KIT), Institute for Pulsed Power and Microwave Technology (IHM), Association EURATOM-KIT, Kaiserstrasse 12, 76131 Karlsruhe (Germany)

    2014-01-15

    Two issues in the cavity design for a Megawatt-class, 240 GHz gyrotron are addressed. Those are first, the effect of a misaligned electron beam on the gyrotron efficiency and second, a possible azimuthal instability of the gyrotron. The aforementioned effects are important for any gyrotron operation, but could be more critical in the operation of Megawatt-class gyrotrons at frequencies above 200 GHz, which will be the anticipated requirement of DEMO. The target is to provide some basic trends to be considered during the refinement and optimization of the design. Self-consistent calculations are the base for simulations wherever possible. However, in cases for which self-consistent models were not available, fixed-field results are presented. In those cases, the conservative nature of the results should be kept in mind.

  1. On the dependence of the efficiency of a 240 GHz high-power gyrotron on the displacement of the electron beam and on the azimuthal index

    International Nuclear Information System (INIS)

    Two issues in the cavity design for a Megawatt-class, 240 GHz gyrotron are addressed. Those are first, the effect of a misaligned electron beam on the gyrotron efficiency and second, a possible azimuthal instability of the gyrotron. The aforementioned effects are important for any gyrotron operation, but could be more critical in the operation of Megawatt-class gyrotrons at frequencies above 200 GHz, which will be the anticipated requirement of DEMO. The target is to provide some basic trends to be considered during the refinement and optimization of the design. Self-consistent calculations are the base for simulations wherever possible. However, in cases for which self-consistent models were not available, fixed-field results are presented. In those cases, the conservative nature of the results should be kept in mind

  2. 2.2 MW Operation of the European Coaxial-Cavity Pre-Prototype Gyrotron for ITER

    International Nuclear Information System (INIS)

    Full text: A 2 MW, CW, 170 GHz coaxial-cavity gyrotron for electron cyclotron heating and current drive in the International Thermonuclear Experimental Reactor (ITER) is under development within an European Gyrotron Consortium (EGYC*). To support the development of the industrial prototype of a CW gyrotron, a short pulse tube (pre-prototype) is used at KIT (former FZK) for experimental verification of the design of critical components, such as electron gun, beam tunnel, cavity and quasi-optical (q.o.) RF-output coupler. Significant progress was achieved recently. In particular, RF output power of up to 2.2 MW with 30% output efficiency has been obtained in single-mode operation at 170 GHz. Furthermore, an excellent quality of the RF output beam with ∼ 96% fundamental Gaussian mode content has been obtained by using a new quasi-optical RF output system. The verification of these results with computer simulations will be presented. (author)

  3. Study of a cylindrical cavity gyrotron, influence of power reflection and of the oscillation of a travelling mode

    International Nuclear Information System (INIS)

    The quality factor and oscillating mode of a gyrotron cavity are essential parameters to consider when trying to obtain a high power (>500 kW), high efficiency (∼50%) microwave source, which oscillates in a stable manner in the principal mode of the cavity. The study and development of an 8 GHz gyrotron whose resonant cavity is formed by a cylindrical waveguide of slowly varying radius, is undertaken. The study is principally concerned with the phenomena associated with the low quality factor of the TEo011 mode of the cavity. (author) figs., tabs., 102 refs

  4. UTAUT2 Based Predictions of Factors Influencing the Technology Acceptance of Phablets by DNP

    Directory of Open Access Journals (Sweden)

    Chi-Yo Huang

    2015-01-01

    Full Text Available The smart mobile devices have emerged during the past decade and have become one of the most dominant consumer electronic products. Therefore, exploring and understanding the factors which can influence the acceptance of novel mobile technology have become the essential task for the vendors and distributors of mobile devices. The Phablets, integrated smart devices combining the functionality and characteristics of both tablet PCs and smart phones, have gradually become possible alternatives for smart phones. Therefore, predicting factors which can influence the acceptance of Phablets have become indispensable for designing, manufacturing, and marketing of such mobile devices. However, such predictions are not easy. Meanwhile, very few researches tried to study related issues. Consequently, the authors aim to explore and predict the intentions to use and use behaviors of Phablets. The second generation of the Unified Theory of Acceptance and Use of Technology (UTAUT2 is introduced as a theoretic basis. The Decision Making Trial and Evaluation Laboratory (DEMATEL based Network Process (DNP will be used to construct the analytic framework. In light of the analytic results, the causal relationships being derived by the DEMATEL demonstrate the direct influence of the habit on other dimensions. Also, based on the influence weights being derived, the use intention, hedonic motivation, and performance expectancy are the most important dimensions. The analytic results can serve as a basis for concept developments, marketing strategy definitions, and new product designs of the future Phablets. The proposed analytic framework can also be used for predicting and analyzing consumers’ preferences toward future mobile devices.

  5. Coupler for coupling gyrotron whispering gallery mode RF into HE11 waveguide

    Science.gov (United States)

    Neilson, Jeffrey M

    2015-02-24

    A cylindrical waveguide with a mode converter transforms a whispering gallery mode from a gyrotron cylindrical waveguide with a helical cut launch edge to a quasi-Gaussian beam suitable for conveyance through a corrugated waveguide. This quasi-Gaussian beam is radiated away from the waveguide using a spiral cut launch edge, which is in close proximity to a first mode converting reflector. The first mode converting reflector is coupled to a second mode converting reflector which provides an output free-space HE11 mode wave suitable for direct coupling into a corrugated waveguide. The radiated beam produced at the output of the second mode converting reflector is substantially circular.

  6. Preliminary design of 1 MW, Ku-band gyrotron traveling-wave amplifier

    Institute of Scientific and Technical Information of China (English)

    Chongqing JIAO

    2009-01-01

    The preliminary design results ofa 1-MW, Ku-band gyrotron traveling wave amplifier (gyro-TWA) are presented. Operating at the second cyclotron harmonic of the TE11 mode, the amplifier characterizes good stability even in the case of no distributed losses loaded, which could potentially allow it to be operated at high average power. Large signal simulation shows that the amplifier can generate a saturated peak power of about 1 MW with efficiency of 26.6%, gain of 31 dB, and 3-dB bandwidth of about 1 GHz when driven by a 100 kV, 40 A electron beam with 5% axial velocity spread.

  7. Design considerations in achieving 1 MW CW operation with a whispering-gallery-mode gyrotron

    International Nuclear Information System (INIS)

    Varian is developing high-power, CW gyrotrons at frequencies in the range 100 GHz to 150 GHz, for use in electron cyclotron heating applications. Early test vehicles have utilized a TE15,2,1 interaction cavity, have achieved short-pulse power levels of 820 kW and average power levels of 80 kW at 140 GHz. Present tests are aimed at reaching 400 kW under CW operating conditions and up to 1 MW for short pulse durations. Work is also underway on modifications to the present design that will enable power levels of up to 1 MW CW to be achieved. 7 refs., 2 figs

  8. Experiment for Over 200 kW Oscillation of a 295 GHz Pulse Gyrotron

    OpenAIRE

    YAMAGUCHI, YuuSuke; SAITO, Teruo; TATEMATSU, Yoshinori; IKEUCHI, Shinji; KASA, Jun; KOTERA, Masaki; Ogawa, Isamu; Idehara, Toshitaka; Kubo, Shin; SHIMOZUMA, Takashi; NISHIURA, Masaki; Tanaka, Kenji

    2013-01-01

    A high-power sub-THz gyrotron is under development as a power source of collective Thomson scatteringdiagnostic of fusion plasmas. It operates at a fundamental harmonic frequency of 295 GHz. A cavity whichrealizes stable and efficient single mode oscillation, an electron gun with an intense laminar electron beam, andan internal mode convertor are designed. A maximum oscillation power of 234kW is achieved with a Gaussianlike radiation pattern. The duration of 130kW pulse is extended up to 30 m...

  9. Advances in high power calorimetric matched loads for short pulses and CW gyrotrons

    International Nuclear Information System (INIS)

    The development of high power gyrotrons for plasma physics research needs properly matched calorimetric loads able to absorb and measure the power, which nowadays is foreseen to be as high as 2 MW during CW operations. To this end IFP/CNR has developed a family of matched loads useful in the mm-wave frequency band for applications ranging from a few ms to CW in pulse length. The different loads in the family, made of an integrating sphere with a partially reflecting coating on the inner wall, are characterized by having the same absorbing geometry for the incoming beam and a different heat removal system for the specific application. Some important advances have been recently achieved from the point of view of the uniformity of power distribution on the absorbing wall and of the load construction. With the high precision achieved in the coating thickness a better control of the heating power distribution is possible by proper shaping of the local reflectivity, in addition to the shaping of the mirror dispersing the input beam. A more sophisticated model describing the power distribution has been developed, taking into account a variable thickness of the absorbing coating, the proper shape of the spreading mirror, the frequency of the incoming radiation and the shape of the input beam. Lower coating thickness is shown to be preferable, for a given local reflectivity, from the point of view of a lower peak temperature and thermal stress. The paper describes a load with variable coating thickness along the meridian of the sphere, showing a uniform power deposition on the inner walls. The cooling pipe is completely electroformed on the spherical copper shell, ensuring the maintenance of the correct curvature of the inner surface and fast heat conduction from the absorbing coating to the water through the thin copper body. For CW use all heated parts of the load must be cooled and this is achieved with 16 electroformed spiral channels. Both short pulse loads (0.1-1 s

  10. Recent operating experience with Varian 70 GHz and 140 GHz gyrotrons

    International Nuclear Information System (INIS)

    The design features and initial test results of Varian 70 GHz and 140 GHz CW gyrotrons are presented. The first experimental 140 GHz tube has achieved an output power of 102 kW at 24% efficiency under pulsed conditions in the desired TE0310 cavity mode. Further tests aimed at achieving the design goal of 100 kW CW are currently underway. The 70 GHz tube has achieved an output power of 200 kW under pulsed conditions and possesses a wide dynamic range for output power variations. 6 refs., 8 figs

  11. Experiment for over 200 kW oscillation of a 295 GHz pulse gyrotron

    International Nuclear Information System (INIS)

    A high-power sub-THz gyrotron is under development as a power source of collective Thomson scattering diagnostic of fusion plasmas. It operates at a fundamental harmonic frequency of 295 GHz. A cavity which realizes stable and efficient single mode oscillation, an electron gun with an intense laminar electron beam, and an internal mode convertor are designed. A maximum oscillation power of 234 kW is achieved with a Gaussian like radiation pattern. The duration of 130 kW pulse is extended up to 30 microseconds, which is limited by the configuration of power supply. (author)

  12. Development of problem-oriented software packages for numerical studies and computer-aided design (CAD) of gyrotrons

    Science.gov (United States)

    Damyanova, M.; Sabchevski, S.; Zhelyazkov, I.; Vasileva, E.; Balabanova, E.; Dankov, P.; Malinov, P.

    2016-03-01

    Gyrotrons are the most powerful sources of coherent CW (continuous wave) radiation in the frequency range situated between the long-wavelength edge of the infrared light (far-infrared region) and the microwaves, i.e., in the region of the electromagnetic spectrum which is usually called the THz-gap (or T-gap), since the output power of other devices (e.g., solid-state oscillators) operating in this interval is by several orders of magnitude lower. In the recent years, the unique capabilities of the sub-THz and THz gyrotrons have opened the road to many novel and future prospective applications in various physical studies and advanced high-power terahertz technologies. In this paper, we present the current status and functionality of the problem-oriented software packages (most notably GYROSIM and GYREOSS) used for numerical studies, computer-aided design (CAD) and optimization of gyrotrons for diverse applications. They consist of a hierarchy of codes specialized to modelling and simulation of different subsystems of the gyrotrons (EOS, resonant cavity, etc.) and are based on adequate physical models, efficient numerical methods and algorithms.

  13. Combined Hyperthermia and Photodynamic Therapy Using a Sub-THz Gyrotron as a Radiation Source

    Science.gov (United States)

    Miyoshi, Norio; Idehara, Toshitaka; Khutoryan, Eduard; Fukunaga, Yukihiro; Bibin, Andriana Bintang; Ito, Shinji; Sabchevski, Svilen Petrov

    2016-08-01

    In this paper, we present results of a hyperthermia treatment of malignant tumors using a gyrotron as a radiation source for heating of the cancerous tissue. They clearly demonstrate the efficiency of the irradiation by sub-THz waves, which leads to steady decrease of the volume of the tumor and finally to its disappearance. A combination of hyperthermia and photodynamic therapy (PDT) that utilizes a novel multifunctional photosensitizer has also been explored. In the latter case, the results are even more convincing and promising. In particular, while after a hyperthermia treatment sometimes a regrowth of the tumor is being observed, in the case of combined hyperthermia and PDT such regrowth has never been noticed. Another combined therapy is based on a preheating of the tumor by gyrotron radiation to temperatures lower than the hyperthermia temperature of 43 °C and followed then by PDT. The results show that such combination significantly increases the efficiency of the treatment. We consider this phenomenon as a synergy effect since it is absent when hyperthermia and PDT are applied separately, and manifests itself only when both methods are combined.

  14. Safety and protection of 8T NbTi gyrotron magnet in persistent mode

    International Nuclear Information System (INIS)

    Successful series of 5T cryomagnetic systems for additional high frequency plasma heating in Tokamaks T10 and T15, produced in Czechoslovakia during the last decade with the authors participation in magnet design and testing encouraged them to continue in further development of gyrotron magnets for further generation with operational field B0 = 8T. Approximately of the size and dimensions as was the case of previous 5T series, the 8T gyrotron magnet was designed as a part of preliminary work with preparations for ITER project. To achieve high mechanical stability of the superconducting winding, numerical stress-strain analyzes of winding structure and appropriate technology of epoxy impregnation were applied. To improve winding mechanical stability, initially round φ1 mm varnish insulated conductor was flattened to ''race track'' cross section (1.25 x 0.75 mm2 for inner section, respectively, 1.31 x 0.65 mm2 for the rest of magnet). Stainless steel road (φ1mm) of the bandage was flattened in the same way too (up to 1.14 x 0.77 mm2). Danger of creating a hot spot region has been limited by radial magnet sectioning and sections shunting by low ohmic shunts. Superconducting switch was protected by couple of antiparallel silicon diodes mounted between magnet flanges in parallel to it. High threshold voltages of diodes at 4.2K allow to run up system with relatively high speed without any limitation on sign of magnet field polarity

  15. Simulation of transient behavior in a pulse-line-driven gyrotron oscillator

    Science.gov (United States)

    Lin, A. T.; Lin, Chih-Chien; Yang, Z. H.; Chu, K. R.; Fliflet, A. W.

    1988-04-01

    Results are reported for a set of slow-time-scale single-mode and fast-time-scale single-mode and multimode simulations of the transient-mode excitation phenomena in a short-pulse high-peak-power Ka-band gyrotron oscillator experiment. Both the slow- and fast-time-scale single-mode simulations are generally in good agreement with each other and, within experimental uncertainties, with the experimental observations of the time dependence and magnetic-field dependence of 35-GHz emission in the TE62 mode. However, the multimode simulations suggest the presence of mode suppression, mode beating, and other nonlinear multimode phenomena that could not easily be observed in the experiment, and generally agree less well with the experimental measurements than the single-mode simulations. The multimode simulations also suggest that steady-state behavior may not be obtainable with the highly time-dependent voltage waveform employed in the experiment, and indicate the importance of carrying out future high-voltage gyrotron experiments with less highly transient voltage waveforms.

  16. Effect of ion compensation of the beam space charge on gyrotron operation

    Energy Technology Data Exchange (ETDEWEB)

    Fokin, A. P.; Glyavin, M. Yu. [Institute of Applied Physics, Russian Academy of Sciences, Nizhny Novgorod 603950 (Russian Federation); Nusinovich, G. S. [Institute for Research in Electronics and Applied Physics, University of Maryland, College Park, Maryland 20742-3511 (United States)

    2015-04-15

    In gyrotrons, the coherent radiation of electromagnetic waves takes place when the cyclotron resonance condition between the wave frequency and the electron cyclotron frequency or its harmonic holds. The voltage depression caused by the beam space charge field changes the relativistic cyclotron frequency and, hence, can play an important role in the beam-wave interaction process. In long pulse and continuous-wave regimes, the beam space charge field can be partially compensated by the ions, which appear due to the beam impact ionization of neutral molecules of residual gases in the interaction space. In the present paper, the role of this ion compensation of the beam space charge on the interaction efficiency is analyzed. We also analyze the effect of the electron velocity spread on the limiting currents and discuss some effects restricting the ion-to-beam electron density ratio in the saturation stage. It is shown that the effect of the ion compensation on the voltage depression caused by the beam space charge field can cause significant changes in the efficiency of gyrotron operation and, in some cases, even result in the break of oscillations.

  17. Beam-wave interaction behavior of a 35 GHz metal PBG cavity gyrotron

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Ashutosh, E-mail: asingh.rs.ece@iitbhu.ac.in [Faculty of Physical Sciences, Institute of Natural Sciences and Humanities Shri Ramswaroop Memorial University, Lucknow-Deva Road, Uttar Pradesh-225003 (India); Center of Research in Microwave Tubes, Department of Electronics Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi-221005 (India); Jain, P. K. [Center of Research in Microwave Tubes, Department of Electronics Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi-221005 (India)

    2014-09-15

    The RF behavior of a 35 GHz photonic band gap (PBG) cavity gyrotron operating in TE{sub 041}-like mode has been presented to demonstrate its single mode operation capability. In this PBG cavity gyrotron, the conventional tapered cylindrical cavity is replaced by a metal PBG cavity as its RF interaction structure. The beam-wave interaction behavior has been explored using time dependent multimode nonlinear analysis as well as through 3D PIC simulation. Metal PBG cavity is treated here similar to that of a conventional cylindrical cavity for the desired mode confinement. The applied DC magnetic field profile has been considered uniform along the PBG cavity length both in analysis as well as in simulation. Electrons energy and phase along the interaction length of the PBG cavity facilitates bunching mechanism as well as energy transfer phenomena from the electron beam to the RF field. The RF output power for the TE{sub 041}-like design mode as well as nearby competing modes have been estimated and found above to 100 kW in TE{sub 041}-like mode with ∼15% efficiency. Results obtained from the analysis and the PIC simulation are found in agreement within 8% variation, and also it supports the single mode operation, as the PBG cavity does not switch into other parasitic modes in considerably large range of varying DC magnetic field, contrary to the conventional cylindrical cavity interaction structure.

  18. Experimental results of the 1 MW, 140 GHz, CW gyrotron for W7-X

    International Nuclear Information System (INIS)

    For the stellarator Wendelstein 7-X now under construction at IPP Greifswald, Germany, a 10 MW ECRH system is foreseen. A European collaboration has been established between Forschungszentrum Karlsruhe (FZK), IPP Garching/Greifswald, IPF Stuttgart, CRPP Lausanne, CEA Cadarache and TED Velizy, to develop and build the 10 gyrotrons each with an output power of 1 MW for continuous wave (CW) operation. The dependence of the output power and efficiency of the first series tube versus the beam current will be shown in short pulse operation (without depressed collector) and in CW operation (up to 30 minutes, depressed collector operation). RF-field measurements have been performed in order to characterise the output field of the gyrotron and to minimise losses during the transmission to the W7-X device. Several parameters have been optimised (e.g. beam radii, magnetic field) to maximise output power and efficiency of the tube. At FZK site, long pulse tests up to 180 s have been performed (limited by the available power supply), at IPP site the pulse length could be extended to 30 min, both at a power level of 1 MW and high efficiency. (author)

  19. Upgrade Of The TH1506B 118 GHz Gyrotron Using Modeing Tools

    International Nuclear Information System (INIS)

    The first TH1506B prototype showing problems of overheating and spurious oscillations, a new modified gyrotron was built. During the tests, the extwo peaks, which was never predicted by simulations. Various low evel tests were performed on the mode converter with different shapes for the launcher but without real improvement. Besides measurements, the use of a new software Surf3D[l] showed that the problem mainly comes from the 3rd mirror whose curvature is too high and not well taken nto account by the calculation. This analysis software is based on ntegral equations and the complete 3D modelling alowed to determine a new profile for the 3rd mirror. An aluminium model of a new mirror was manufactured and thorough low level tests made at FZK showed that there was no double peak.The next step would consist in building a gyrotron based on this new design, to confirm the simulation and to valdate it for long pulses

  20. Characteristics of a superconducting magnet using a persistent current for a 110 GHz gyrotron

    Energy Technology Data Exchange (ETDEWEB)

    Maebara, Sunao; Kasugai, Atsushi; Sakamoto, Keishi; Tsuneoka, Masaki; Imai, Tsuyoshi [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment

    1996-03-01

    A superconducting magnet (SCM) using a persistent current for a 110 GHz gyrotron was developed to reduce liquid-helium loss, the boiled-off rate of 0.13 liter/hour was attained in a persistent current operation. It shows that the continuous operation for 50 days is capable without additional liquid-helium supply. Moreover, the 3040 liter in a year is used for a gyrotron test during five months and for the maintenance during seven months and liquid-helium savings of 65% was successfully demonstrated. The SCM is capable to excite the maximum magnetic field of 5.0 T in the persistent current mode. A mirror ratio between resonant cavity and magnetron injection gun (MIG) is 20 for operating the main coils in the persistent mode, since cavity coils and gun coils are connected in series. Auxiliary coils are equipped independently to control the mirror ratio, the mirror ratio of 13.6 - 37.0 at the 110 GHz is available. A two-stage refrigerator using helium gas was also installed and made liquid-nitrogen for cooling thermal shield of 80 K free. By developing this new type SCM, the number of routine works was drastically decreased in one time per 22-50 days, while routine works of a few times per week was needed up to now. (author).

  1. Electrical and thermo-mechanical analysis of beam recovery system for megawatt power gyrotron

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharya, Ranajoy, E-mail: joy_trm@yahoo.com [Central Electronics Engineering Research Institute (CEERI), Pilani, Rajasthan 333031 (India); Sahu, Naveen Kr [Central Electronics Engineering Research Institute (CEERI), Pilani, Rajasthan 333031 (India); Khan, Arani Ali [Department of Electronics and Communication, Indian Institute of Technology, Kharagpur (India); Khatun, Hasina; Sinha, A.K. [Central Electronics Engineering Research Institute (CEERI), Pilani, Rajasthan 333031 (India)

    2013-05-15

    Highlights: • Electrical design of single stage depressed collector for high power gyrotron tube. • Efficiency enhancement by collecting spent beam. • Optimization of geometry and magnetic field for optimized beam spread. • Optimization of cooling duct system for better thermal management. -- Abstract: The paper presents the electrical and thermo-mechanical design of single stage beam recovery system for 120 GHz, 1 MW gyrotron. The electrical study shows that the cylindrical shape single stage beam recovery system enhances the efficiency by 66.26%. The maximum power deposited to collector in depressed collector operation is 0.48 MW for electronic efficiency, 30% and 1.44 MW for DC electron beam. The thermo-mechanical analysis has been performed to evaluate the water cooling system. The cooling system has capability of accommodating a peak wall loading, 0.9 kW/cm{sup 2} at flow rate of 1500 l/min for safe operating time, 60 ms. Further, a high voltage analysis is also carried out to appraise the electric field distribution in the collector.

  2. Nonlinear study of mode locking in a quasi-optical gyrotron

    Science.gov (United States)

    Wu, Hao; McCurdy, Alan H.

    1996-10-01

    Nonlinear, time-dependent multimode calculations have been carried out to study mode locking in quasi-optical gyrotron oscillators. The calculations are based on the rate equation model of modal growth and saturation. The slow-time formalism is used for particle motion and both the time varying electric and magnetic fields are included. It is found that radiation pulses of width 400 ps can be generated in nonlinear regime. The gyrotron features an open resonator of length 100 cm formed by a pair of spherical mirrors and a single pencil electron beam guided by external magnetic field in transverse direction to the axis of symmetry of the cavity. The strong current modulation is provided at frequency of 300 MHz, the nominal model spacing between two odd modes in such a cavity. Eight odd modes are found to be locked to generate extremely short radiation pulses. Application for short pulse radiation in millimeter and submillimeter wavelength range include radar, plasma diagnosis, time domain metrology and communication systems. Parametric dependencies investigated include static magnetic field, beam current and beam voltage, as well as the drive signal amplitudes and frequencies. The work is geared towards support of a proof of principle experiment to generate high power radiation pulses of short duration via synchronous mode locking.

  3. Study of the degradation the products of DNP from the rat thymus by methods of gel filtration on sepharose 4B and ultracentrifuging in a suerose gradient

    International Nuclear Information System (INIS)

    By means of ultracentrifuging, in a gradient of sucrose, of DNP degradation products obtained by gel filtration on Sepharose 4B of salt extracts from the rat thymus (six hours after irradiation and administration of degranol), heterogeneity of their DNA-protein complex has been shown on the one hand and similarity in the fragment sets after irradiation and administration of degranol, on the other. These results and those obtained earlier support the idea of similar pathways of DNP degradation in thymocytes to be the response to the irreversible lesions of these cells

  4. Continuous-Wave Operation of a Frequency-Tunable 460-GHz Second-Harmonic Gyrotron for Enhanced Nuclear Magnetic Resonance.

    Science.gov (United States)

    Torrezan, Antonio C; Han, Seong-Tae; Mastovsky, Ivan; Shapiro, Michael A; Sirigiri, Jagadishwar R; Temkin, Richard J; Barnes, Alexander B; Griffin, Robert G

    2010-06-01

    The design, operation, and characterization of a continuous-wave (CW) tunable second-harmonic 460-GHz gyrotron are reported. The gyrotron is intended to be used as a submillimeter-wave source for 700-MHz nuclear magnetic resonance experiments with sensitivity enhanced by dynamic nuclear polarization. The gyrotron operates in the whispering-gallery mode TE(11,2) and has generated 16 W of output power with a 13-kV 100-mA electron beam. The start oscillation current measured over a range of magnetic field values is in good agreement with theoretical start currents obtained from linear theory for successive high-order axial modes TE(11,2,q). The minimum start current is 27 mA. Power and frequency tuning measurements as a function of the electron cyclotron frequency have also been carried out. A smooth frequency tuning range of 1 GHz was obtained for the operating second-harmonic mode either by magnetic field tuning or beam voltage tuning. Long-term CW operation was evaluated during an uninterrupted period of 48 h, where the gyrotron output power and frequency were kept stable to within ±0.7% and ±6 ppm, respectively, by a computerized control system. Proper operation of an internal quasi-optical mode converter implemented to transform the operating whispering-gallery mode to a Gaussian-like beam was also verified. Based on the images of the gyrotron output beam taken with a pyroelectric camera, the Gaussian-like mode content of the output beam was computed to be 92% with an ellipticity of 12%. PMID:21243088

  5. Long-lived states of magnetically equivalent spins populated by dissolution-DNP and revealed by enzymatic reactions.

    Science.gov (United States)

    Bornet, Aurélien; Ji, Xiao; Mammoli, Daniele; Vuichoud, Basile; Milani, Jonas; Bodenhausen, Geoffrey; Jannin, Sami

    2014-12-15

    Hyperpolarization by dissolution dynamic nuclear polarization (D-DNP) offers a way of enhancing NMR signals by up to five orders of magnitude in metabolites and other small molecules. Nevertheless, the lifetime of hyperpolarization is inexorably limited, as it decays toward thermal equilibrium with the nuclear spin-lattice relaxation time. This lifetime can be extended by storing the hyperpolarization in the form of long-lived states (LLS) that are immune to most dominant relaxation mechanisms. Levitt and co-workers have shown how LLS can be prepared for a pair of inequivalent spins by D-DNP. Here, we demonstrate that this approach can also be applied to magnetically equivalent pairs of spins such as the two protons of fumarate, which can have very long LLS lifetimes. As in the case of para-hydrogen, these hyperpolarized equivalent LLS (HELLS) are not magnetically active. However, a chemical reaction such as the enzymatic conversion of fumarate into malate can break the magnetic equivalence and reveal intense NMR signals.

  6. Long-Lived States of Magnetically Equivalent Spins Populated by Dissolution-DNP and Revealed by Enzymatic Reactions**

    Science.gov (United States)

    Bornet, Aurélien; Ji, Xiao; Mammoli, Daniele; Vuichoud, Basile; Milani, Jonas; Bodenhausen, Geoffrey; Jannin, Sami

    2014-01-01

    Hyperpolarization by dissolution dynamic nuclear polarization (d-DNP) offers a way of enhancing NMR signals by up to five orders of magnitude in metabolites and other small molecules. Nevertheless, the lifetime of hyperpolarization is inexorably limited, as it decays toward thermal equilibrium with the nuclear spin-lattice relaxation time. This lifetime can be extended by storing the hyperpolarization in the form of long-lived states (LLS) that are immune to most dominant relaxation mechanisms. Levitt and co-workers have shown how LLS can be prepared for a pair of inequivalent spins by d-DNP. Here, we demonstrate that this approach can also be applied to magnetically equivalent pairs of spins such as the two protons of fumarate, which can have very long LLS lifetimes. As in the case of para-hydrogen, these hyperpolarized equivalent LLS (HELLS) are not magnetically active. However, a chemical reaction such as the enzymatic conversion of fumarate into malate can break the magnetic equivalence and reveal intense NMR signals. PMID:25346515

  7. Power-stabilization of high frequency gyrotrons using a double PID feedback control for applications to many high power THz spectroscopy

    OpenAIRE

    Kuleshov, Alexei; Ueda, Keisuke; Idehara, Toshitaka

    2013-01-01

    High stabilization of the output power of high frequency gyrotrons for high power THzspectroscopy is an important issue in order to extend the applications of gyrotrons to wider subjects.For this objective, we tried a PID feedback control on a heater current of a triode magnetroninjection gun (MIG) for stabilization of an electron beam current and an additional PID control ofan anode voltage of the gun for direct stabilization of output power. This double PID controlachieves effective respons...

  8. Formation of Multicharged Metal Ions in Vacuum Arc Plasma Heated by Gyrotron Radiation%Formation of Multicharged Metal Ions in Vacuum Arc Plasma Heated by Gyrotron Radiation

    Institute of Scientific and Technical Information of China (English)

    G. Yu. YUSHKOV; K. P. SAVKIN; A. G. NIKOLAEV; E. M. OKS; A.V. VODOPYANOV; I. V. IZOTOV; D. A. MANSFELD

    2011-01-01

    A new method for the generation of high charged state metal ion beams is developed. This method is based on microwave heating of vacuum arc plasma in a magnetic trap under electron cyclotron resonance (ECR) conditions. Two gyrotrons for plasma heating were used, which were with the following parameters. The first is with a wave frequency of 37.5 GHz, a pulse duration of 1 ms and power of 100 kW, another is with 75 GHz, 0.15 ms and 400 kW. Two different magnetic traps were considered for vacuum arc plasma confinement. The first one is a simple mirror trap. Such system was already investigated and could provide high charge state ions. The second trap was with a cusp magnetic field configuration with native "minimum-B" field structure. Two different ways of metal plasma injection into the magnetic trap were used. The first one is an axial injection from an arc source located out of the trap, and the second is a radial injection from four arc sources mounted at the center of the trap. Both traps provide up to 200 eMA of ion beam current for platinum ions with highest charge state 10+. Ion beams were successfully extracted from the plasma and accelerated by a voltage of up to 20 kV.

  9. The DNP by 2015: A Study of the Institutional, Political, and Professional Issues That Facilitate or Impede Establishing a Post-Baccalaureate Doctor of Nursing Practice Program

    Science.gov (United States)

    Auerbach, David I.; Martsolf, Grant R.; Pearson, Marjorie L.; Taylor, Erin Audrey; Zaydman, Mikhail; Muchow, Ashley; Spetz, Joanne; Dower, Catherine

    2015-01-01

    In 2004, members of the American Association of Colleges of Nursing (AACN) voted to endorse a position statement identifying the doctor of nursing practice (DNP) degree as the most appropriate degree for advanced-practice registered nurses (APRNs) to enter practice. At the same time, AACN members voted to approve the position that all master's…

  10. High-power, stable Ka/V dual-band gyrotron traveling-wave tube amplifier

    Science.gov (United States)

    Hung, Chien-Lun

    2012-05-01

    A dual-band amplifier can reduce the size, cost, and weight of a transmitter in dual-band radar and communication systems. This study proposes and theoretically investigates a gyrotron traveling-wave tube (gyro-TWT) amplifier capable of dual-band operation. Possible oscillations in the coaxial interaction waveguide are stabilized by the lossy inner cylinder. Under stable operating conditions, the gyro-TWT is predicted to provide a peak power of 375 kW with 71 dB saturated gain and 3.8 GHz bandwidth in the Ka-band and a peak power of 150 kW with 35 dB saturated gain and 1.7 GHz bandwidth in the V-band.

  11. 1 megawatt, 100 GHz gyrotron study. Final report, March 21-September 1, 1983

    International Nuclear Information System (INIS)

    This report provides the results of a design study on a gyrotron device employing a new type of hollow gyrobeam formation system and having a capability for delivering megawatt CW power at 100 GHz to an ECRH-heated, magnetically-confined plasma. The conceptual basis for the beam formation system is the tilt-angle gun (TAG) in which a conically-shaped electron beam is formed in a magnetically-shielded region and is then injected into the stray-field region of the main magnetic focusing system. Because fluid coolants can be accessed through the central pole of the TAG-type gun, rf interaction can be contemplated with cavity configurations not practical with the conventional MIG-type gyrobeam formation systems

  12. Systematic Observation of Time-Dependent Phenomena in the RF Output Spectrum of High Power Gyrotrons

    Directory of Open Access Journals (Sweden)

    Kern Stefan

    2012-09-01

    Full Text Available At IHM/KIT, high power gyrotrons with conventional cavity (e.g. 1 MW CW at 140 GHz for the stellarator Wendelstein 7-X and coaxial cavity (2 MW shortpulse at 170 GHz for ITER for fusion applications are being developed and verified experimentally. Especially with respect to the problem of parasitic RF oscillations in the beam tunnel of some W7-X tubes, investigations of the gyrotron RF output spectrum have proved to be a valuable source of diagnostic information. Signs of transient effects in millisecond pulses, like frequency switching or intermittent low-frequency modulation, have indicated that truly time-dependent measurements with high frequency resolution and dynamic range could give deeper insight into these phenomena. In this paper, an improved measurement system is presented, which employs a fast oscilloscope as receiver. Shorttime Fourier transform (STFT is applied to the time-domain signal, yielding time-variant spectra with frequency resolutions only limited by acquisition length and STFT segmentation choice. Typical reasonable resolutions are in the range of 100 kHz to 10 MHz with a currently memory-limited maximum acquisition length of 4 ms. A key feature of the system consists in the unambiguity of frequency measurement: The system receives through two parallel channels, each using a harmonic mixer (h = 9 – 12 to convert the signal from RF millimeter wave frequencies (full D-Band, 110 – 170 GHz to IF (0 – 3 GHz. For each IF output signal of each individual mixer, injection side and receiving harmonic are initially not known. Using accordingly determined LO frequencies, this information is retrieved from the redundancy of the channels, yielding unambiguously reconstructed RF spectra with a total span of twice the usable receiver IF bandwidth, up to ≈ 6 GHz in our case. Using the system, which is still being improved continuously, various transient effects like cavity mode switching, parasitic oscillation frequency variation

  13. Systematic Observation of Time-Dependent Phenomena in the RF Output Spectrum of High Power Gyrotrons

    Science.gov (United States)

    Schlaich, Andreas; Gantenbein, Gerd; Kern, Stefan; Thumm, Manfred

    2012-09-01

    At IHM/KIT, high power gyrotrons with conventional cavity (e.g. 1 MW CW at 140 GHz for the stellarator Wendelstein 7-X) and coaxial cavity (2 MW shortpulse at 170 GHz for ITER) for fusion applications are being developed and verified experimentally. Especially with respect to the problem of parasitic RF oscillations in the beam tunnel of some W7-X tubes, investigations of the gyrotron RF output spectrum have proved to be a valuable source of diagnostic information. Signs of transient effects in millisecond pulses, like frequency switching or intermittent low-frequency modulation, have indicated that truly time-dependent measurements with high frequency resolution and dynamic range could give deeper insight into these phenomena. In this paper, an improved measurement system is presented, which employs a fast oscilloscope as receiver. Shorttime Fourier transform (STFT) is applied to the time-domain signal, yielding time-variant spectra with frequency resolutions only limited by acquisition length and STFT segmentation choice. Typical reasonable resolutions are in the range of 100 kHz to 10 MHz with a currently memory-limited maximum acquisition length of 4 ms. A key feature of the system consists in the unambiguity of frequency measurement: The system receives through two parallel channels, each using a harmonic mixer (h = 9 - 12) to convert the signal from RF millimeter wave frequencies (full D-Band, 110 - 170 GHz) to IF (0 - 3 GHz). For each IF output signal of each individual mixer, injection side and receiving harmonic are initially not known. Using accordingly determined LO frequencies, this information is retrieved from the redundancy of the channels, yielding unambiguously reconstructed RF spectra with a total span of twice the usable receiver IF bandwidth, up to ≈ 6 GHz in our case. Using the system, which is still being improved continuously, various transient effects like cavity mode switching, parasitic oscillation frequency variation, and lowfrequency

  14. Insight into the Supramolecular Architecture of Intact Diatom Biosilica from DNP-Supported Solid-State NMR Spectroscopy.

    Science.gov (United States)

    Jantschke, Anne; Koers, Eline; Mance, Deni; Weingarth, Markus; Brunner, Eike; Baldus, Marc

    2015-12-01

    Diatom biosilica is an inorganic/organic hybrid with interesting properties. The molecular architecture of the organic material at the atomic and nanometer scale has so far remained unknown, in particular for intact biosilica. A DNP-supported ssNMR approach assisted by microscopy, MS, and MD simulations was applied to study the structural organization of intact biosilica. For the first time, the secondary structure elements of tightly biosilica-associated native proteins in diatom biosilica were characterized in situ. Our data suggest that these proteins are rich in a limited set of amino acids and adopt a mixture of random-coil and β-strand conformations. Furthermore, biosilica-associated long-chain polyamines and carbohydrates were characterized, thereby leading to a model for the supramolecular organization of intact biosilica.

  15. Systematic cavity design approach for a multi-frequency gyrotron for DEMO and study of its RF behavior

    Science.gov (United States)

    Kalaria, P. C.; Avramidis, K. A.; Franck, J.; Gantenbein, G.; Illy, S.; Pagonakis, I. Gr.; Thumm, M.; Jelonnek, J.

    2016-09-01

    High frequency (>230 GHz) megawatt-class gyrotrons are planned as RF sources for electron cyclotron resonance heating and current drive in DEMOnstration fusion power plants (DEMOs). In this paper, for the first time, a feasibility study of a 236 GHz DEMO gyrotron is presented by considering all relevant design goals and the possible technical limitations. A mode-selection procedure is proposed in order to satisfy the multi-frequency and frequency-step tunability requirements. An effective systematic design approach for the optimal design of a gradually tapered cavity is presented. The RF-behavior of the proposed cavity is verified rigorously, supporting 920 kW of stable output power with an interaction efficiency of 36% including the considerations of realistic beam parameters.

  16. Free-electron masers vs. gyrotrons prospects for high-power sources at millimeter and submillimeter wavelengths

    CERN Document Server

    Thumm, M K

    2002-01-01

    The possible applications of high-power millimeter (mm) and sub-mm waves from free-electron masers (FEMs) and gyro-devices span a wide range of technologies. The plasma physics community has already taken advantage of recent advances in applying high-power mm waves generated by long pulse or continuous wave (CW) gyrotron oscillators and short pulse very high-power FEMs in the areas of RF-plasma production, heating, non-inductive current drive, plasma stabilization and active plasma diagnostics for magnetic confinement thermonuclear fusion research, such as electron cyclotron resonance heating (28-170 GHz), electron cyclotron current drive , collective Thomson scattering , microwave transmission and heat-wave propagation experiments. Continuously frequency tunable FEMs could widen these fields of applications. Another important application of CW gyrotrons is industrial materials processing, e.g. sintering of high-performance functional and structural nanostructured ceramics. Sub-mm wave sources are employed in...

  17. Effects of INH, DNP, 2,4-D and CMU on the photosynthetic activity of barley and maize plants; Efecto de cuatro inhibidores metabolicos (INH, DNP, 2, 4-D y CMU) sobre la actividad fotosintetica de plantular de cebada (Hordeum vulgare L.) y Maiz (Zea mais L.)

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, J.; Prieto, M. P.

    1979-07-01

    Determinations of the rate of photosynthesis were made in barley and maize leaves treated with INH, DNP, 2,4-D or CMU. 1 ppm of the chemicals in nutritive solutions was absorbed by roots during 24 or 48 hours in both dark and light conditions. After this period, photosynthetic activity, compensation point and 14{sup C}O{sub 2} assimilation were determined. Results show that INH increases the rate of photosynthesis, DNP and 2,4-D do not alter it sensibly and CMU acts as a strong inhibitor of photosynthesis. Some possible applications for ths obtention of labelled compounds by biosynthesis are discussed. (Author) 87 refs.

  18. The interplay between the solid effect and the cross effect mechanisms in solid state 13C DNP at 95 GHz using trityl radicals

    Science.gov (United States)

    Banerjee, Debamalya; Shimon, Daphna; Feintuch, Akiva; Vega, Shimon; Goldfarb, Daniella

    2013-05-01

    The 13C solid state Dynamic Nuclear Polarization (DNP) mechanism using trityl radicals (OX63) as polarizers was investigated in the temperature range of 10-60 K. The solutions used were 6 M 13C urea in DMSO/H2O (50% v/v) with 15 mM and 30 mM OX63. The measurements were carried out at ˜3.5 T, which corresponds to Larmor frequencies of 95 GHz and 36 MHz for the OX63 and the 13C nuclei, respectively. Measurements of the 13C signal intensity as a function of the microwave (MW) irradiation frequency yielded 13C DNP spectra with temperature dependent lineshapes for both samples. The maximum enhancement for the 30 mM sample was reached at 40 K, while that of the 15 mM sample at 20-30 K. Furthermore, the lineshapes observed showed that both the cross effect (CE) and the solid effect (SE) DNP mechanisms are active in this temperature range and that their relative contribution is temperature dependent. Simulations of the spectra with the relative contributions of the CE and SE mechanisms as a fit parameter revealed that for both samples the CE contribution decreases with decreasing temperature while the SE contribution increases. In addition, for the 15 mM sample the contributions of the two mechanisms are comparable from 20 K to 60 K while for the 30 mM the CE dominates in this range, as expected from the higher concentration. The steep decrease of the CE contribution towards low temperatures is however unexpected. The temperature dependence of the OX63 longitudinal relaxation, DNP buildup times and 13C spin lattice relaxation times did not reveal any obvious correlation with the DNP temperature dependence. A similar behavior of the CE and SE mechanism was observed for 1H DNP with the nitroxide radical TEMPOL as a polarizer. This suggests that this effect is a general phenomenon involving a temperature dependent competition between the CE and SE mechanisms, the source of which is, however, still unknown.

  19. Development of a dual frequency (110/138 GHz gyrotron for JT-60SA and its extension to an oscillation at 82 GHz

    Directory of Open Access Journals (Sweden)

    Kobayashia Takayuki

    2015-01-01

    Full Text Available A dual-frequency gyrotron, which can generate 110 GHz and 138 GHz waves independently, is being developed in JAEA to enable electron cyclotron heating (ECH and current drive (ECCD in a wider range of plasma discharge conditions of JT-60SA. Conditioning operation of the gyrotron toward 1 MW for 100 s, which is the target output power and pulse length for JT-60SA, is in progress without significant problems. Oscillations of 1 MW for 10 s and 0.5 MW for 198 s were obtained, so far, at both frequencies. Cooling water temperatures in the gyrotron and matching optics unit were saturated in the 198 s oscillation, and the observed maximum water temperature is sufficiently low. In addition to the above activity on the dual-frequency gyrotron development, an oscillation (0.3 MW for 20 ms at 82 GHz was demonstrated as an additional frequency of the dual-frequency gyrotron. A possibility of the use of fundamental harmonic wave at 82 GHz in JT-60SA has been shown.

  20. Theoretical study on mode competition between fundamental and second harmonic modes in a 0.42 THz gyrotron with gradually tapered complex cavity

    International Nuclear Information System (INIS)

    In this paper, the nonlinear dynamics of mode competition in the complex cavity gyrotron are studied by using multi-frequency, time-dependent theory with the cold-cavity longitudinal profile approximation. Based on the theory, a code is written to simulate the mode competition in the gradually tapered complex cavity gyrotron operating at second harmonic oscillation. The simulations tracking seven competition modes show that single mode oscillation of the desired mode TE17.4 at 150 kW level can be expected with proper choice of operating parameters. Through studying on mode competition, it is proved that the complex cavity has a good capability for suppressing the mode competition. Meanwhile, it is found that TE17.3 could be excited in the first cavity as a competition mode when the gyrotron operating at large beam current, which leads to that TE17.3 and TE17.4 with different frequencies can coexist stably in the complex cavity gyrotron with very close amplitudes. Thus, the complex cavity might be used for multi-frequency output gyrotron

  1. Real-Time DNP NMR Observations of Acetic Acid Uptake, Intracellular Acidification, and of Consequences for Glycolysis and Alcoholic Fermentation in Yeast

    DEFF Research Database (Denmark)

    Jensen, Pernille Rose; Karlsson, Magnus; Lerche, Mathilde Hauge;

    2013-01-01

    Uptake and upshot in vivo: Straightforward methods that permit the real-time observation of organic acid influx, intracellular acidification, and concomitant effects on cellular-reaction networks are crucial for improved bioprocess monitoring and control (see scheme). Herein, dynamic nuclear...... polarization (DNP) NMR is used to observe acetate influx, ensuing intracellular acidification and the metabolic consequences on alcoholic fermentation and glycolysis in living cells....

  2. THE ROLE OF THREE WILD ANIMALS IN THE DISTRIBUTION OF PREFERRED FORAGE PLANTS IN THE DINDER NATIONAL PARK (D.N.P SUDAN

    Directory of Open Access Journals (Sweden)

    F. A. MOHAMMED

    2013-07-01

    Full Text Available This study was conducted in Dinder National Park (D.N.P. of Sudan during the dry season (March, April and May. Waterbuck (Kobus defassa, warthog (Phacochoerus aethiopicus and Tiang (Damaliscus korrigum in D.N.P were chosen for this study. Seeds of Acacia nubica, Acacia seyal and Piliostigma reticulatum recovered from the fecal samples of waterbuck showed a highly increased rate of germination above the control. Acacia polycantha and Sesbania sesban showed decreased rate of germination below the control. The germination rate of Acacia siberiana showed no positive effect (zero versus the control. The germination rate of the seeds of Ziziphus-spina-christi remained more or less above the control (53% and 50%, respectively. The germination of seeds of Ziziphus spina-christi from fecal samples of warthog showed higher increased rate of germination. The results of this study confirmed that the three wild herbivores are grazers, but they shift their diets towards forbs, woody plants and fruits of leguminous trees during the dry season. Waterbuck, Tiang and Warthog they depended on the plant diversely around water collecting places in the pank (Mayas for their diets, but they selected other plant species from the surrounding. Also this study provides the information regarding food habits and feed requirements of these wild herbivores. Such information might help in the management of the habitat (Mayas and the protection and sustainability of wild herbivores in D.N.P.

  3. Low-voltage harmonic multiplying gyrotron traveling-wave amplifier in G band

    International Nuclear Information System (INIS)

    Harmonic multiplying operation in a gyrotron traveling-wave amplifier (gyro-TWA) permits for magnetic field reduction and frequency multiplication. Lowering a beam voltage is an important step toward miniaturization of a harmonic multiplying gyro-TWA. However, the additional degree of freedom that is provided by the multitude cyclotron harmonics in a low-voltage harmonic multiplying gyro-TWA still easily generates various competing modes. An improved mode-selective circuit, using circular waveguides with various radii, can provide the rejection points within the frequency range to suppress competing modes. Simulated results reveal that the mode-selective circuit can provide an attenuation of more than 14 dB to suppress the competing modes. Furthermore, the performance of the gyro-TWA is analyzed for studying the sensitivity of the saturated output power and full width at half maximum bandwidth of the gyro-TWA to the beam voltage and the magnetic field. A stable low-voltage harmonic multiplying gyro-TWA with the mode-selective circuit is predicted to yield a peak output power of 24 kW at 200.4 GHz, corresponding to a saturated gain of 56 dB at an interaction efficiency of 20%. The full width at half maximum bandwidth is 3.0 GHz

  4. G-band harmonic multiplying gyrotron traveling-wave amplifier with a mode-selective circuit

    International Nuclear Information System (INIS)

    Harmonic multiplying gyrotron traveling-wave amplifiers (gyro-TWAs) permit for magnetic field reduction and frequency multiplication. A high-order-mode harmonic multiplying gyro-TWA with large circuit dimensions and low ohmic loss can achieve a high average power. By amplifying a fundamental harmonic TE01 drive wave, the second harmonic component of the beam current initiates a TE02 wave to be amplified. Wall losses can suppress some competing modes because they act as an effective sink of the energy of the modes. However, such wall losses do not suppress all competing modes as the fields are contracted in the copper section in the gyro-TWA. An improved mode-selective circuit, using circular waveguides with the specified radii, can provide the rejection points within the frequency range to suppress the competing modes. The simulated results reveal that the mode-selective circuit can provide an attenuation of more than 10 dB to suppress the competing modes (TE21, TE51, TE22, and TE03). A G-band second harmonic multiplying gyro-TWA with the mode-selective circuit is predicted to yield a peak output power of 50 kW at 198.8 GHz, corresponding to a saturated gain of 55 dB at an interaction efficiency of 10%. The full width at half maximum bandwidth is 5 GHz

  5. Mechanisms of amplification of ultrashort electromagnetic pulses in gyrotron traveling wave tube with helically corrugated waveguide

    International Nuclear Information System (INIS)

    A time-domain self consistent theory of a gyrotron traveling wave tube with a helically corrugated operating waveguide has been developed. Based on this model, the process of short pulse amplification was studied in regimes of grazing and intersection of the dispersion curves of the electromagnetic wave and the electron beam. In the first case, the possibility of amplification without pulse form distortion was demonstrated for the pulse spectrum width of the order of the gain bandwidth. In the second case, when the electrons' axial velocity was smaller than the wave's group velocity, it was shown that the slippage of the incident signal with respect to the electron beam provides feeding of the signal by “fresh” electrons without initial modulation. As a result, the amplitude of the output pulse can exceed the amplitude of its saturated value for the case of the grazing regime, and, for optimal parameters, the peak output power can be even larger than the kinetic power of the electron beam

  6. Mechanisms of amplification of ultrashort electromagnetic pulses in gyrotron traveling wave tube with helically corrugated waveguide

    Science.gov (United States)

    Ginzburg, N. S.; Zotova, I. V.; Sergeev, A. S.; Zaslavsky, V. Yu.; Zheleznov, I. V.; Samsonov, S. V.; Mishakin, S. V.

    2015-11-01

    A time-domain self consistent theory of a gyrotron traveling wave tube with a helically corrugated operating waveguide has been developed. Based on this model, the process of short pulse amplification was studied in regimes of grazing and intersection of the dispersion curves of the electromagnetic wave and the electron beam. In the first case, the possibility of amplification without pulse form distortion was demonstrated for the pulse spectrum width of the order of the gain bandwidth. In the second case, when the electrons' axial velocity was smaller than the wave's group velocity, it was shown that the slippage of the incident signal with respect to the electron beam provides feeding of the signal by "fresh" electrons without initial modulation. As a result, the amplitude of the output pulse can exceed the amplitude of its saturated value for the case of the grazing regime, and, for optimal parameters, the peak output power can be even larger than the kinetic power of the electron beam.

  7. Experimental results of the 140 GHz, 1 MW long-pulse gyrotron for W7-X

    Science.gov (United States)

    Koppenburg, K.; Arnold, A.; Borie, E.; Dammertz, G.; Giguet, E.; Heidinger, R.; Illy, S.; Kuntze, M.; Le Cloarec, G.; Legrand, F.; Leonhardt, W.; Lievin, C.; Neffe, G.; Piosczyk, B.; Schmid, M.; Thumm, M.

    2003-02-01

    Gyrotrons at high frequency with high output power are mainly developed for microwave heating and current drive in plasmas for thermonuclear fusion. For the stellarator Wendelstein 7-X now under construction at IPP Greifswald, Germany, a 10 MW ECRH system is foreseen. A 1 MW, 140 GHz long-pulse gyrotron has been designed and a pre-prototype (Maquette) has been constructed and tested in an European collaboration between FZK Karlsruhe, CRPP Lausanne, IPF Suttgart, IPP Greifswald, CEA Cadarache and TED Vélizy [1]. The cylindrical cavity is designed for operating in the TE28,8 mode. It is a standard tapered cavity with linear input downtaper and a non-linear uptaper. The diameter of the cylindrical part is 40.96 mm. The transitions between tapers and straight section are smoothly rounded to avoid mode conversion. The TE28,8-cavity mode is transformed to a Gaussian TEM0,0 output mode by a mode converter consisting of a rippled-wall waveguide launcher followed by a three mirror system. The output window uses a single, edge cooled CVD-diamond disk with an outer diameter of 106 mm, a window aperture of 88 mm and a thickness of 1.8 mm corresponding to four half wavelengths. The collector is at ground potential, and a depression voltage for energy recovery can be applied to the cavity and to the first two mirrors. Additional normal-conducting coils are employed to the collector in order to produce an axial magnetic field for sweeping the electron beam with a frequency of 7 Hz. A temperature limited magnetron injection gun without intermediate anode ( diode type ) is used. In short pulse operation at the design current of 40 A an output power of 1 MW could be achieved for an accelerating voltage of 82 kV without depression voltage and with a depression voltage of 25 kV an output power of 1.15 MW at an accelerating voltage of 84 kV has been measured. For these values an efficiency of 49% was obtained. At constant accelerating voltages, the output power did not change up to

  8. Intense high-frequency gyrotron-based microwave beams for material processing

    Energy Technology Data Exchange (ETDEWEB)

    Hardek, T.W.; Cooke, W.D.; Katz, J.D.; Perry, W.L.; Rees, D.E.

    1997-03-01

    Microwave processing of materials has traditionally utilized frequencies in the 0.915 and 2.45 GHz regions. Microwave power sources are readily available at these frequencies but the relatively long wavelengths can present challenges in uniformly heating materials. An additional difficulty is the poor coupling of ceramic based materials to the microwave energy. Los Alamos National Laboratory scientists, working in conjunction with the National Center for Manufacturing Sciences (NCMS), have assembled a high-frequency demonstration processing facility utilizing gyrotron based RF sources. The facility is primarily intended to demonstrate the unique features available at frequencies as high as 84 GHz. The authors can readily provide quasi-optical, 37 GHz beams at continuous wave (CW) power levels in the 10 kW range. They have also provided beams at 84 GHz at 10 kW CW power levels. They are presently preparing a facility to demonstrate the sintering of ceramics at 30 GHz. This paper presents an overview of the present demonstration processing facility and describes some of the features they have available now and will have available in the near future.

  9. Analysis and design of double-anode magnetron injection gun for 170 GHz gyrotron

    International Nuclear Information System (INIS)

    Based on adiabatic compression theory and electro-optical theory, a double-anode magnetron injection gun for 170 GHz gyrotron was designed. By theoretical analysis and calculations, using simulation software to simulate and optimize the electron gun, and got the result that the velocity ratio of electron beam was 1.31, the transverse velocity spread was 3.5% and the axial velocity spread was 7.1%, the beam current was 51 A. The effects of the cathode magnetic field, the control Jantage and the second anode Jantage on the properties of electron beam were discussed and found that electron beam were very sensitive with these factors. When cathode magnetic field increased, the velocity ratio of electron beam decreased, the axial velocity spread increased first and then decreased, the transverse velocity spread decreased first and then increased. The increase of the first anode Jantage could improve the velocity ratio and velocity spread of electron beam. The closer the anode angle and cathode angle, the smaller axial velocity spread. The transverse velocity spread became smaller while the anode angle changed toward the direction of reducing the distance between anode could cathode. When the two anode Jantage did not change, the increase of the distance between cathode and anode could minish the velocity spread of electron beam but the velocity ratio decreased at the same time. (authors)

  10. Low-order-mode harmonic multiplying gyrotron traveling-wave amplifier in W band

    Energy Technology Data Exchange (ETDEWEB)

    Yeh, Y. S.; Chen, C. H.; Yang, S. J.; Lai, C. H.; Lin, T. Y.; Lo, Y. C.; Hong, J. W. [Department of Electro-Optical Engineering, Southern Taiwan University, Tainan, Taiwan (China); Hung, C. L. [Department of Communication Engineering, National Penghu University of Science and Technology, Penghu, Taiwan (China); Chang, T. H. [Department of Physics, National Tsing Hua University, Hsinchu, Taiwan (China)

    2012-09-15

    Harmonic multiplying gyrotron traveling-wave amplifiers (gyro-TWAs) allow for magnetic field reduction and frequency multiplication. To avoid absolute instabilities, this work proposes a W-band harmonic multiplying gyro-TWA operating at low-order modes. By amplifying a fundamental harmonic TE{sub 11} drive wave, the second harmonic component of the beam current initiates a TE{sub 21} wave to be amplified. Absolute instabilities in the gyro-TWA are suppressed by shortening the interaction circuit and increasing wall losses. Simulation results reveal that compared with Ka-band gyro-TWTs, the lower wall losses effectively suppress absolute instabilities in the W-band gyro-TWA. However, a global reflective oscillation occurs as the wall losses decrease. Increasing the length or resistivity of the lossy section can reduce the feedback of the oscillation to stabilize the amplifier. The W-band harmonic multiplying gyro-TWA is predicted to yield a peak output power of 111 kW at 98 GHz with an efficiency of 25%, a saturated gain of 26 dB, and a bandwidth of 1.6 GHz for a 60 kV, 7.5 A electron beam with an axial velocity spread of 8%.

  11. Low-voltage harmonic multiplying gyrotron traveling-wave amplifier in G band

    Energy Technology Data Exchange (ETDEWEB)

    Yeh, Y. S.; Guo, Y. W.; Kao, B. H.; Chen, C. H.; Wang, Z. W. [Department of Electro-Optical Engineering, Southern Taiwan University of Science and Technology, Tainan, Taiwan (China); Hung, C. L. [Department of Communication Engineering, National Penghu University of Science and Technology, Penghu, Taiwan (China); Chang, T. H. [Department of Physics, National Tsing Hua University, Hsinchu, Taiwan (China)

    2015-12-15

    Harmonic multiplying operation in a gyrotron traveling-wave amplifier (gyro-TWA) permits for magnetic field reduction and frequency multiplication. Lowering a beam voltage is an important step toward miniaturization of a harmonic multiplying gyro-TWA. However, the additional degree of freedom that is provided by the multitude cyclotron harmonics in a low-voltage harmonic multiplying gyro-TWA still easily generates various competing modes. An improved mode-selective circuit, using circular waveguides with various radii, can provide the rejection points within the frequency range to suppress competing modes. Simulated results reveal that the mode-selective circuit can provide an attenuation of more than 14 dB to suppress the competing modes. Furthermore, the performance of the gyro-TWA is analyzed for studying the sensitivity of the saturated output power and full width at half maximum bandwidth of the gyro-TWA to the beam voltage and the magnetic field. A stable low-voltage harmonic multiplying gyro-TWA with the mode-selective circuit is predicted to yield a peak output power of 24 kW at 200.4 GHz, corresponding to a saturated gain of 56 dB at an interaction efficiency of 20%. The full width at half maximum bandwidth is 3.0 GHz.

  12. Mechanisms of amplification of ultrashort electromagnetic pulses in gyrotron traveling wave tube with helically corrugated waveguide

    Energy Technology Data Exchange (ETDEWEB)

    Ginzburg, N. S., E-mail: ginzburg@appl.sci-nnov.ru; Zaslavsky, V. Yu. [Institute of Applied Physics of the Russian Academy of Sciences, 46 Ul' yanov Str., 603950 Nizhny Novgorod (Russian Federation); Nizhny Novgorod State University, 23 Gagarin Ave., 603950 Nizhny Novgorod (Russian Federation); Zotova, I. V.; Sergeev, A. S.; Zheleznov, I. V.; Samsonov, S. V.; Mishakin, S. V. [Institute of Applied Physics of the Russian Academy of Sciences, 46 Ul' yanov Str., 603950 Nizhny Novgorod (Russian Federation)

    2015-11-15

    A time-domain self consistent theory of a gyrotron traveling wave tube with a helically corrugated operating waveguide has been developed. Based on this model, the process of short pulse amplification was studied in regimes of grazing and intersection of the dispersion curves of the electromagnetic wave and the electron beam. In the first case, the possibility of amplification without pulse form distortion was demonstrated for the pulse spectrum width of the order of the gain bandwidth. In the second case, when the electrons' axial velocity was smaller than the wave's group velocity, it was shown that the slippage of the incident signal with respect to the electron beam provides feeding of the signal by “fresh” electrons without initial modulation. As a result, the amplitude of the output pulse can exceed the amplitude of its saturated value for the case of the grazing regime, and, for optimal parameters, the peak output power can be even larger than the kinetic power of the electron beam.

  13. Three-Dimensional Numerical Simulation of a 30-GHz Gyrotron Resonator With an Explicit High-Order Discontinuous-Galerkin-Based Parallel Particle-In-Cell Method

    DEFF Research Database (Denmark)

    Stock, Andreas; Neudorfer, Jonathan; Riedlinger, Marc;

    2012-01-01

    and the operating setup. For the first time, we apply a fully electromagnetic (EM) transient 3-D high-order discontinuous Galerkin particle-in-cell method solving the complete self-consistent nonlinear Vlasov–Maxwell equations to simulate a 30-GHz high-power millimeter-wave gyrotron resonator without physical......Fast design codes for the simulation of the particle–field interaction in the interior of gyrotron resonators are available. They procure their rapidity by making strong physical simplifications and approximations, which are not known to be valid for many variations of the geometry...

  14. Development of a dual frequency (110/138 GHz) gyrotron for JT-60SA and its extension to an oscillation at 82 GHz

    OpenAIRE

    Kobayashia Takayuki; Moriyama Shinichi; Isayama Akihiko; Sawahata Masayuki; Terakado Masayuki; Hiranai Shinichi; Wada Kenji; Sato Yoshikatsu; Hinata Jun; Yokokura Kenji; Hoshino Katsumichi; Sakamoto Keishi

    2015-01-01

    A dual-frequency gyrotron, which can generate 110 GHz and 138 GHz waves independently, is being developed in JAEA to enable electron cyclotron heating (ECH) and current drive (ECCD) in a wider range of plasma discharge conditions of JT-60SA. Conditioning operation of the gyrotron toward 1 MW for 100 s, which is the target output power and pulse length for JT-60SA, is in progress without significant problems. Oscillations of 1 MW for 10 s and 0.5 MW for 198 s were obtained, so far, at both fre...

  15. Suppression of the Oscillatory Modes of a Space Charge in the Magnetron Injection Guns of Technological Gyrotrons

    Science.gov (United States)

    Glyavin, M. Yu.; Kuntsevich, A. D.; Manuilov, V. N.

    2015-01-01

    We present the results of based on the PIC method numerical simulation of the dynamic processes of trapping of electrons into the adiabatic trap of a technological gyrotron for different configurations of the electric and magnetic fields in the electron beam formation region. The electrode geometry providing a low reflection coefficient of the magnetic mirror to suppress oscillatory modes in the space-charge cloud and ensure the stability of the electron beam with a high fraction of oscillatory energy in such a system has been found.

  16. Development program for a 200 kW, CW gyrotron. Quarterly report No. 16, April-June 1983

    International Nuclear Information System (INIS)

    The objective of this program is the design and development of a millimeter-wave device to produce 200 kW of continuous wave power at 60 GHz. The device, a gyrotron oscillator, will be compatible with power delivery to an electron-cyclotron heated plasma. Smooth control of rf power over a 17 dB range is required, and the device should be capable of operation into a severely time-varying load mismatch. Progress is presented in the testing, analyses and understanding of S/N 1B behavior and in preparing S/N 3 for test in the coming report period

  17. 60 GHz gyrotron development program. Final report, April 1979-June 1984

    International Nuclear Information System (INIS)

    The original objective of this program was to develop a microwave amplifier or oscillator capable of producing 200 kW CW power output at 110 GHz. The use of cyclotron resonance interaction was pursued, and the design phases of this effort are discussed. Later, however, the program's objective was changed to develop a family of oscillators capable of producing 200 kw of peak output power at 60 GHz. Gyrotron behavior studies were performed at 28 GHz to obtain generic design information as quickly as possible. The first experimental device at 60 GHz produced over 200 kw of peak power at a pulse duration of 20 μs. Heating problems and mode interference were encountered. The second experimental tube incorporated an optimized gun location but also suffered from mode interference. The third experimental tube included modifications that reduced mode interference. It demonstrated 200 kw of peak output at 100 ms pulse duration. The fourth experimental tube, which used an older rf circuit design but in a CW configuration, produced 71.5 kW CW. The fifth experimental tube incorporated a thinner double-disc output window which improved window bandwidth and reduced window loss. This tube also incorporated modifications to the drift tunnel and cavity coupling, which had proven successful in the third experimental pulse tube tests. It produced 123 kW of CW output power at 60 GHz rf load coolant boiling and tube window failure terminated the tests. A new waterload was designed and constructed, and alternative window designs were explored

  18. Design of an ultra-broadband single-disk output window for a frequency step-tunable 1 MW gyrotron

    International Nuclear Information System (INIS)

    Output window design is one of the key issues to realize broadband output of a multi-frequency gyrotron. Corresponding to the recent development of a frequency step-tunable 1 MW gyrotron at Forschungszentrum Karlsruhe (FZK), this paper reports about a newly designed ultra-broadband CVD-diamond disk Brewster window. The thickness of the disk and the geometry of the window unit have been optimized to get low power reflection over a broadband incident angle range around the Brewster angle at different operating frequencies. Detailed calculations of mm-wave transmission characteristics for this Brewster window have been performed for all the considered operation modes from TE17,6 at 105 GHz up to TE23,8 at 143 GHz, and for thickness of the disk from 1.5 to 2.0 mm. Calculations show if one prefers to place the low reflection area in the middle of the discussed frequency range (120-130 GHz), the thickness of 1.6 mm is near optimum and its -20 dB bandwidth angle is more than 30o. For operation near 105 and 140 GHz, a 1.9 mm disk is preferable and its -20 dB bandwidth angle is around 30o

  19. Free-electron masers vs. gyrotrons: prospects for high-power sources at millimeter and submillimeter wavelengths

    Science.gov (United States)

    Thumm, Manfred

    2002-05-01

    The possible applications of high-power millimeter (mm) and sub-mm waves from free-electron masers (FEMs) and gyro-devices span a wide range of technologies. The plasma physics community has already taken advantage of recent advances in applying high-power mm waves generated by long pulse or continuous wave (CW) gyrotron oscillators and short pulse very high-power FEMs in the areas of RF-plasma production, heating, non-inductive current drive, plasma stabilization and active plasma diagnostics for magnetic confinement thermonuclear fusion research, such as electron cyclotron resonance heating (28-170 GHz), electron cyclotron current drive , collective Thomson scattering , microwave transmission and heat-wave propagation experiments. Continuously frequency tunable FEMs could widen these fields of applications. Another important application of CW gyrotrons is industrial materials processing, e.g. sintering of high-performance functional and structural nanostructured ceramics. Sub-mm wave sources are employed in high-frequency broadband electron paramagnetic resonance and other types of spectroscopy. Future applications which await the development of novel high-power FEM amplifiers and gyro-amplifiers include high-resolution radar ranging and imaging in atmospheric and planetary science as well as deep-space and specialized satellite communications and RF drivers for next-generation high-gradient linear accelerators (supercolliders). The present paper reviews the state-of-the-art and future prospects of these recent applications of gyro-devices and FEMs and compares their specific advantages.

  20. Development Program for a 200-kW, c-w gyrotron. Quarterly report No. 14, October-December 1982

    International Nuclear Information System (INIS)

    The objective of this program is the design and development of a millimeter-wave device to produce 200 kW of continuous-wave power at 60 GHz. The device, a gyrotron oscillator, will be compatible with power delivery to an electron-cyclotron plasma. Smooth control of RF power output over a 17 dB range is required, and the device should be capable of operation into a severe time-varying load mismatch. Continued testing of S/N 1 A was limited by boiling in the water load. An efficiency of 48.9 percent was achieved at 3.3 amps cathode current. Extensive experimentation with eclectic water-load configurations was performed and significant progress was made toward a permanent load configuration. Testing was completed on S/N 2. This gyrotron had a limited operating range due to a nonconcentric cathode. After regunning, initial tests on S/N 2A produced 150 kW RF on the diagnostic modulator. Further investigation of a beam instability problem, which occurs under certain magnetic-field conditions, was performed on S/N 2A. Corrective action has been taken on S/N 3 to suppress this oscillation

  1. Effects of INH, DNP, 2, 4-D and CMU on the sugar content of the barley and maize leaves; Efecto de cuatro inhibidores metabolicos (INH, DNP, 2, 3-D y CMU) sobre el contenido en azucares de hohas de cebada (Hordeum vulgare L.) y Maiz (Zea mais L.)

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, J.; Sancho, P.

    1979-07-01

    1 ppm of the chemicals in nutritive solution was absorbed by barley and maize roots during 24 and 48 hours in dark or light conditioners in order to determine the best conditions. for the obtention of labelled sugars with high specific activity. Results show that the highest specific activity was obtained In maize plants treated with DNP for 24 hours in dark conditions. (Author) 51 refs.

  2. Chemical-shift-resolved ¹⁹F NMR spectroscopy between 13.5 and 135 MHz: Overhauser-DNP-enhanced diagonal suppressed correlation spectroscopy.

    Science.gov (United States)

    George, Christy; Chandrakumar, Narayanan

    2014-08-01

    Overhauser-DNP-enhanced homonuclear 2D (19)F correlation spectroscopy with diagonal suppression is presented for small molecules in the solution state at moderate fields. Multi-frequency, multi-radical studies demonstrate that these relatively low-field experiments may be operated with sensitivity rivalling that of standard 200-1000 MHz NMR spectroscopy. Structural information is accessible without a sensitivity penalty, and diagonal suppressed 2D NMR correlations emerge despite the general lack of multiplet resolution in the 1D ODNP spectra. This powerful general approach avoids the rather stiff excitation, detection, and other special requirements of high-field (19)F NMR spectroscopy.

  3. XPD对SMMC-7721肝癌细胞中DNp73和GADD45β的调控及意义%Overexpression of XPD decreases DNp73 expression and increases GADD45β expression in SMMC-7721 hepatoma cells

    Institute of Scientific and Technical Information of China (English)

    王芬芬; 张吉翔

    2012-01-01

    AIM: To evaluate the impact of transfection with the XPD gene on the expression of DNp73 and GADD45p and cell proliferation and apoptosis in human hepatoma cell line SMMC-7721.METHODS: After SMMC-7721 cells were trans-fected with SMMC-7721-pEGFP-N2-XPD, the mRNA and protein expression of DNp73 and GADD45β was detected by RT-PCR and Western blot, respectively; cell proliferation was assessed by MTT assay; and the changes in cell apoptosis were evaluated by flow cytometry.RESULTS: Compared to control cells, the expres-sion of DNp73 mRNA decreased significantly and that of XPD and GADD45β mRNAs was enhanced obviously in cells transfected with XPD (all P < 0.01). Similar results were obtained for the expression of XPD, DNp73 and GADD45p proteins. The proliferation of SMMC-7721 cells was markedly inhibited and the apoptosis of SMMC-7721 cells was increased after transfection with XPD (both P< 0.01).CONCLUSION: The wild-type XPD plays an important inhibitory role in the carcinogenesis of HCC. Overexpression of XPD decreases the expression of DNp73 and increases the expression of GADD45p, which suggests that both DNp73 and GADD45p may play a key role in the inhibitory effect of XPD on the carcinogenesis of HCC.%目的:观察人剪切修复基因人类着色性干皮病D组基因(xeroderma pigmentosum group D,XPD)转染至人肝癌细胞株SMMC-7721细胞后XPD、DNp73和GADD45p基因的表达变化以及对肝癌细胞生长的影响.方法:实验分4组:重组质粒SMMC-7721-pEGFP-N2-XPD(XPD组)、空载质粒SMMC-7721-pEGFP-N2组(N2组),脂质体组和SMMC-7721细胞空白对照组.应用Lipofectamine2000脂质体瞬时转染,逆转录聚合酶链反应(RT-PCR)和蛋白印迹(Westernblot)法检测转XPD基因后,人肝癌细胞株SMMC-7721细胞中DNp73以及GADD45β的mRNA和蛋白质的表达量变化,并用四甲基偶氮唑盐(MTT)法检测细胞增殖的活力,流式细胞仪检测细胞凋亡的变化.结果:荧光显微镜下,XPD组和N2组细胞中观察到

  4. Effects of tapering structures on the characteristics of a coaxial-waveguide gyrotron backward-wave oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Hung, C. L. [Department of Communication Engineering, National Penghu University of Science and Technology, Penghu 880, Taiwan (China); Chang, T. H. [Department of Physics, National Tsing Hua University, Hsinchu 300, Taiwan (China); Yeh, Y. S. [Department of Electro-Optical Engineering, Southern Taiwan University, Tainan 710, Taiwan (China)

    2011-10-15

    This study analyzes the characteristics of a gyrotron backward-wave oscillator (gyro-BWO) with a longitudinally tapered coaxial-waveguide by using a single-mode, self-consistent nonlinear code. Simulation results indicate that although tapering the inner wall or the outer wall can significantly raise the start-oscillation current, the former is more suitable for mode selection than the latter because an increase of the start-oscillation current by a tapered inner wall heavily depends on the chosen C value (i.e., the average ratio of the outer radius to the inner radius over the axial waveguide length). Selective suppression of the competing mode by tapering the inner wall is numerically demonstrated. Moreover, efficiency of the coaxial gyro-BWO is increased by tapering the outer wall. Properly down-tapering the outer wall ensures that the coaxial gyro-BWO can reach a maximum efficiency over twice that with a uniform one.

  5. Optimizing the coupling of output of a quasi-optical gyrotron owing to a diffraction grating with ellipsoidal support

    International Nuclear Information System (INIS)

    The output scheme of a quasi-optical gyrotron has been optimized in order to produce a gaussian output microwave beam suitable for transmission over long distances. The technique which has been applied consists of substituting one of the mirrors of the Fabry-Perot resonator in which the particle-wave interaction takes place by a diffraction grating placed in the -1 order Littrow mount and designed such that only orders -1 and 0 can propagate. In such a configuration, the diffraction angle of the order -1 coincides exactly with the incidence direction, thus providing a feedback in the cavity, whereas the order 0 constitutes the output of the resonator. A theoretical study of the power content in each diffracted order of a planar grating of infinite extent with equally spaced linear grooves as a function of the grating parameters has been performed. It has been shown that parameter domains can be found, which provide appropriate efficiencies in both orders for an application on a quasi-optical gyrotron. The Littrow condition was then adapted in order to match the spherical wavefronts of a gaussian beam incident on a possibly non-planar surface. The grooves become thus curvilinear and are no longer equally spaced. Measurements made on a cold test stand have confirmed the validity of the Littrow condition extension and allowed to determine its limits. It has also been shown that this type of cavity provides a mode having an optimal gaussian content and giving a minimal cavity transmission. The angular dispersion of the grating leads to a higher cavity transmission and to a slightly lower gaussian content for the adjacent resonator modes. The fundamental eigenmode electric field profile has been measured inside the cavity and is similar to that of an equivalent resonator made with two spherical mirrors. (author) figs., tabs., 141 refs

  6. Generation of electron beams in cyclotron motion and its interaction with electromagnetic fields in weakly irregular cavities: a study applied to conceptual elaboration of a 35 GHz gyrotron

    International Nuclear Information System (INIS)

    It is presented an investigation of different phenomena that occur in the gyrotron: 1) generation and transport of helical electron beams, 2) interaction of electrons in cyclotron motion with a transverse electric mode in resonant cavities operating near cutoff and 3) electron deposition over the collector active region. An exact ballistic model, which points out the nonlinear attributes of the relativistic equation of electron cyclotron motion and that includes a complex formulation for the longitudinal electric field distribution in weakly irregular waveguides, is used. Physically realizable RF field profiles are studied with the objective of maximizing gyrotron efficiency. For this purpose, an investigation is made of the resonant properties of truncated cones cavities and a new resonator type, with a profile described in terms of a continuous function, is developed. High perpendicular efficiencies (ηperpendicularMAX=0.86) have been calculated for interaction at the fundamental 1cyclotron harmonic and for uniform external magnetic field. A maximum efficiency scaling parameter S has been introduced, by which scaling relations ηperpendicularMAX= ηperpendicularMAX (S) are applicable to a variety of field profiles. The conceptual design of a 35 GHz gyrotron gives emphasis to selection criteria of operating parameters in compliance with technical constraints and with the requirement of soft self-excited oscillations. The proposed gyrotron operates in the azimuthally symetrical mode TE021 and is able to produce, with an electronic efficiency of 40%, an output power of 100 kW, in pulses of 20 ms, with a duty factor of 0.04%. (author)

  7. Linear and nonlinear analysis of a gyro-peniotron oscillator and study of start-up scenario in a high order mode gyrotron

    Science.gov (United States)

    Yeddulla, Muralidhar

    The Cyclotron Resonant Maser (CRM) is a device in which electrons gyrating in an external magnetic field produce coherent EM radiation. A DC electron beam current must be converted to an AC beam current to create RF energy. There are two possible approaches: phase bunching (O-type) and spatial segregation (M-type). In phase bunching, electrons are either accelerated or decelerated depending on when the electrons enter the interaction region, causing phase bunching. The electron bunches are then slowed down by the RF field for energy extraction. Not all electrons lose energy; some even gain energy. In spatial segregation, electrons entering the interaction region at different times are deflected in different directions. With an appropriate spatially varying RF field, all electrons can lose energy leading to very high conversion efficiency. A CRM with a smooth walled cylindrical waveguide interaction cavity and an annular electron beam passing through it can generate very large amount of RF energy. Depending on the electron beam position a gyrotron (O-type device) and a gyro-peniotron (M-type device) are possible. In this work, first, a nonlinear theory to study CRMs with a smooth walled cylindrical waveguide interaction cavity is presented. The nonlinear set of differential equations are linearized to study the starting conditions of the device. A gyro-peniotron operating in the TE0.2 -mode is studied using the theory presented. It is found that a gyro-peniotron operating in a low order mode can be self excited without mode competition from gyrotron modes, leading to the possibility of a very efficient high power RF source. A higher order mode gyro-peniotron experiences severe mode competition from gyrotron modes. The cavity Q required for gyro-peniotron operation is very high, which can lead to excessive heat in the cavity walls due to ohmic losses. Hence, a gyro-peniotron operation seems practical only in low order modes and in short pulses. Second, an existing

  8. Control of the Superconducting Magnets current Power Supplies of the TJ-II Gyrotrons; Control de las Fuentes de Corriente de las Bobinas Superconductoras de los Girotrones del TJ-II

    Energy Technology Data Exchange (ETDEWEB)

    Ros, A.; Fernandez, A.; Tolkachev, A.; Catalan, G.

    2006-07-01

    The TJ-II ECRH heating system consists of two gyrotrons, which can deliver a maximum power of 300 kW at a frequency of 53.2 GHz. Another 28 GHz gyrotron is going to be used in the Bernstein waves heating system. In order to get the required frequency, the gyrotrons need and homogeneous magnetic field of several tesla, which is generated by a superconducting coil field by a current source. This document describes the current source control as well as the high precision ammeters control. These ammeters measure the current in the superconducting coils. The user interface and the programming of the control system are described. The communication between devices is also explained. (author) 9 Refs.

  9. A high-order particle-in-cell method for low density plasma flow and the simulation of gyrotron resonator devices

    Energy Technology Data Exchange (ETDEWEB)

    Stock, Andreas

    2013-04-26

    Within this thesis a parallelized, transient, three-dimensional, high-order discontinuous Galerkin Particle-in-Cell solver is developed and used to simulate the resonant cavity of a gyrotron. The high-order discontinuous Galerkin approach - a Finite-Element type method - provides a fast and efficient algorithm to numerically solve Maxwell's equations used within this thesis. Besides its outstanding dissipation and dispersion properties, the discontinuous Galerkin approach easily allows for using unstructured grids, as required to simulate complex-shaped engineering devices. The discontinuous Galerkin approach approximates a wavelength with significantly less degrees of freedom compared to other methods, e.g. Finite Difference methods. Furthermore, the parallelization capabilities of the discontinuous Galerkin framework are excellent due to the very local dependencies between the elements. These properties are essential for the efficient numerical treatment of the Vlasov-Maxwell system with the Particle-in-Cell method. This system describes the self-consistent interaction of charged particles and the electromagnetic field. As central application within this thesis gyrotron resonators are simulated with the discontinuous Galerkin Particle-in-Cell method on high-performance-computers. The gyrotron is a high-power millimeter wave source, used for the electron cyclotron resonance heating of magnetically confined fusion plasma, e.g. in the Wendelstein 7-X experimental fusion-reactor. Compared to state-of-the-art simulation tools used for the design of gyrotron resonators the Particle-in-Cell method does not use any significant physically simplifications w.r.t. the modelling of the particle-field-interaction, the geometry and the wave-spectrum. Hence, it is the method of choice for validation of current simulation tools being restricted by these simplifications. So far, the Particle-in-Cell method was restricted to be used for demonstration calculations only, because

  10. A Stable 0.2-THz Coaxial-Waveguide Gyrotron Traveling-Wave-Tube Amplifier with Distributed Losses

    Science.gov (United States)

    Hung, C. L.; Yeh, Y. S.; Chang, T. H.; Fang, R. S.

    2016-08-01

    For high-power operation, a THz gyrotron traveling-wave-tube (gyro-TWT) amplifier must operate in a high-order waveguide mode to enlarge the transverse dimension of an interaction waveguide. However, a gyro-TWT amplifier operating in a high-order waveguide mode is susceptible to spurious oscillations. To improve the device stability, in this study, we investigate the possibility of using a coaxial waveguide with distributed losses as the interaction structure. For the same required attenuation, all threatening oscillating modes can be suppressed using different combinations of losses of inner and outer cylinders. This provides flexibility in designing distributed losses when considering the ohmic loading of the interaction structure. We predict that the 0.2-THz gyro-TWT can stably produce a peak power of 14 kW with an efficiency of 23 %, a 3-dB bandwidth of 3.5 GHz, and a saturated gain of 50 dB for a 20-kV 3-A electron beam with a 5 % velocity spread and 1.0 velocity ratio.

  11. Design and measurement of a TE13 input converter for high order mode gyrotron travelling wave amplifiers

    Science.gov (United States)

    Wang, Yan; Liu, Guo; Shu, Guoxiang; Yan, Ran; Wang, Li; Agurgo Balfour, E.; Fu, Hao; Luo, Yong; Wang, Shafei

    2016-03-01

    A technique to launch a circular TE13 mode to interact with the helical electron beam of a gyrotron travelling wave amplifier is proposed and verified by simulation and cold test in this paper. The high order (HOM) TE13 mode is excited by a broadband Y-type power divider with the aid of a cylindrical waveguide system. Using grooves and convex strips loaded at the lateral planes of the output cylindrical waveguide, the electric fields of the potential competing TE32 and TE71 modes are suppressed to allow the transmission of the dominant TE13 mode. The converter performance for different structural dimensions of grooves and convex strips is studied in detail and excellent results have been achieved. Simulation predicts that the average transmission is ˜-1.8 dB with a 3 dB bandwidth of 7.2 GHz (91.5-98.7 GHz) and port reflection is less than -15 dB. The conversion efficiency to the TE32 and TE71 modes are, respectively, under -15 dB and -24 dB in the operating frequency band. Such an HOM converter operating at W-band has been fabricated and cold tested with the radiation boundary. Measurement from the vector network analyzer cold test and microwave simulations show a good reflection performance for the converter.

  12. Stability analysis of a two-stage tapered gyrotron traveling-wave tube amplifier with distributed losses

    Energy Technology Data Exchange (ETDEWEB)

    Hung, C. L. [Department of Communication Engineering, National Penghu University of Science and Technology, Penghu 880, Taiwan (China); Lian, Y. H.; Cheng, N. H. [Graduate Institute of Electrical Engineering and Computer Science, National Penghu University of Science and Technology, Penghu 880, Taiwan (China); Yeh, Y. S. [Department of Electro-Optical Engineering, Southern Taiwan University of Science and Technology, Tainan 710, Taiwan (China); Chang, T. H. [Department of Physics, National Tsing Hua University, Hsinchu 300, Taiwan (China)

    2012-11-15

    The two-stage tapered gyrotron traveling-wave tube (gyro-TWT) amplifier has achieved wide bandwidth in the millimeter wave range. However, possible oscillations in each stage limit this amplifier's operating beam current and thus its output power. To further enhance the amplifier's stability, distributed losses are applied to the interaction circuit of the two-stage tapered gyro-TWT. A self-consistent particle-tracing code is used for analyzing the beam-wave interactions. The stability analysis includes the effects of the wall losses and the length of each stage on the possible oscillations. Simulation results reveal that the distributed-loss method effectively stabilizes all the oscillations in the two stages. Under stable operating conditions, the device is predicted to produce a peak power of 60 kW with an efficiency of 29% and a saturated gain of 52 dB in the Ka-band. The 3-dB bandwidth is 5.7 GHz, which is approximately 16% of the center frequency.

  13. High power rf amplifiers for accelerator applications: The large orbit gyrotron and the high current, space charge enhanced relativistic klystron

    Energy Technology Data Exchange (ETDEWEB)

    Stringfield, R.M.; Fazio, M.V.; Rickel, D.G.; Kwan, T.J.T.; Peratt, A.L.; Kinross-Wright, J.; Van Haaften, F.W.; Hoeberling, R.F.; Faehl, R.; Carlsten, B.; Destler, W.W.; Warner, L.B.

    1990-01-01

    Los Alamos is investigating a number of high power microwave sources for their potential to power advanced accelerators. Included in this investigation are the large orbit gyrotron amplifier and oscillator (LOG) and the relativistic klystron amplifier (RKA). LOG amplifier development is newly underway. Electron beam power levels of 3 GW, 70 ns duration, are planned, with anticipated conversion efficiencies into RF on the order of 20 percent. Ongoing investigations on this device include experimental improvement of the electron beam optics, and computational studies of resonator design and RF extraction. Recent RKA studies have operated at electron beam powers into the device of 1.35 GW in microsecond duration pulses. The device has yielded modulated electron beam power approaching 300 MW using 3--5 kW of RF input drive. RF powers extracted into waveguide have been up to 70 MW, suggesting that more power is available from the device that we have converted to-date in the extractor. We have examined several aspects of operation, including beam bunching phenomena and RF power extraction techniques. In addition, investigations of the amplifier gain as a function of input drive, electron beam parameters and axial magnetic field strength also have been explored. The effect of ions formed during device operation also has been considered.

  14. Automated Microwave Complex on the Basis of a Continuous-Wave Gyrotron with an Operating Frequency of 263 GHz and an Output Power of 1 kW

    Science.gov (United States)

    Glyavin, M. Yu.; Morozkin, M. V.; Tsvetkov, A. I.; Lubyako, L. V.; Golubiatnikov, G. Yu.; Kuftin, A. N.; Zapevalov, V. E.; V. Kholoptsev, V.; Eremeev, A. G.; Sedov, A. S.; Malygin, V. I.; Chirkov, A. V.; Fokin, A. P.; Sokolov, E. V.; Denisov, G. G.

    2016-02-01

    We study experimentally the automated microwave complex for microwave spectroscopy and diagnostics of various media, which was developed at the Institute of Applied Physics of the Russian Academy of Sciences in cooperation with GYCOM Ltd. on the basis of a gyrotron with a frequency of 263 GHz and operated at the first gyrofrequency harmonic. In the process of the experiments, a controllable output power of 0 .1 -1 kW was achieved with an efficiency of up to 17 % in the continuous-wave generation regime. The measured radiation spectrum with a relative width of about 10 -6 and the frequency values measured at various parameters of the device are presented. The results of measuring the parameters of the wave beam, which was formed by a built-in quasioptical converter, as well as the data obtained by measuring the heat loss in the cavity and the vacuum output window are analyzed.

  15. Rapid Sintering of Silica Xerogel Ceramic Derived from Sago Waste Ash Using Sub-millimeter Wave Heating with a 300 GHz CW Gyrotron

    Science.gov (United States)

    Aripin, Haji; Mitsudo, Seitaro; Sudiana, I. Nyoman; Tani, Shinji; Sako, Katsuhide; Fujii, Yutaka; Saito, Teruo; Idehara, Toshitaka; Sabchevski, Sliven

    2011-06-01

    In this paper, we present and discuss experimental results from a microwave sintering of a silica-glass ceramic, produced from a silica xerogel extracted from a sago waste ash. As a radiation source for the microwave heating a sub-millimeter wave gyrotron (Gyrotron FU CW I) with an output frequency of 300 GHz has been used. The powders of silica xerogel have been dry pressed and then sintered at temperatures ranging from 300°C to 1500°C. The influence of the sintering temperature on the technological properties such as porosity and bulk density was studied in detail. Furthermore, X-ray diffraction (XRD) and Fourier Transform Infrared (FTIR) spectroscopy have been used in order to study the structure of the produced silica glass-ceramics. It has been found that the silica xerogel crystallizes at a temperature of 800°C, which is about 200°C lower than the one observed in the conventional process. The silica xerogel samples sintered by their irradiation with a sub-millimeter wave at 900°C for 18 minutes are fully crystallized into a silica glass-ceramic with a density of about 2.2 g/cm3 and cristobalite as a major crystalline phase. The results obtained in this study allow one to conclude that the microwave sintering with sub-millimeter waves is an appropriate technological process for production of silica glass-ceramics from a silica xerogel and is characterized with such advantages as shorter times of the thermal cycle, lower sintering temperatures and higher quality of the final product.

  16. Design of megawatt gyrotrons

    International Nuclear Information System (INIS)

    The design parameters of a 120 GHz gyromonotron capable of output powers in excess of 1 MW are determined. A nonlinear model of the interaction between the beam and rf field is used in which the efficiency is a function of only three normalized variables. By expressing the technological constraints in terms of these variables, permissible design parameters yielding high efficiency operation can be calculated. Constraints that are considered include ohmic heating of the walls, voltage depression of the beam, reduced coupling between the beam and rf field due to beam thickness, and efficiency degradation due to space charge forces within the beam. An analysis of the tradeoffs between current and voltage at the 1 MW level indicates that lower order modes can be utilized at lower voltages, but the constraints based on current limitations are difficult to satisfy. An 80 kV, 29 A design is presented that achieves a total efficiency of 44%. The primary uncertainty of these designs is the severity of competition due to parasitic modes. However, a number of isolated asymmetric modes appear capable of single mode emission at 1 MW based on present experimental results. Multimegawatt operation is also considered. It is shown that powers exceeding 20 MW are possible if single mode operation can be achieved in very high order modes. The methodology presented in this paper is general and can be easily adapted to other frequencies and output powers

  17. 170 GHz回旋管电子枪的设计%Design of the magnetron injection gun for 170 GHz gyrotron

    Institute of Scientific and Technical Information of China (English)

    曾旭; 王峨锋; 刘本田; 李志良; 冯进军

    2013-01-01

    A 170 GHz gryotron is an ideal power source for the Electron Cyclotron Resonance Heating (ECRH) in the plasma fusion. The required output power from a single gyrotron tube at 170 GHz operating frequency for ECRH application is 1 MW or more. For generating the high output power,a Magnetron Injection Gun(MIG) which can provide the electron beam with large enough transverse energy for interacting with the transverse filed of the electromagnetic wave is designed. Ideal parameters of the double-anode MIG are obtained according to the adiabatic compression theory and the correlative simulation software. The designed MIG can provide the necessary beams for the 170 GHz fundamental harmonic gyrotron under 80 kV of voltage and 40 A of current with the guidance center radius of 8.27 mm and the pitch factor of 1.5.%  170 GHz回旋管是等离子体核聚变中电子回旋谐振加热的理想功率源,在功率上要求具有1 MW以上的输出功率。要产生这么大的输出功率,就需要具有足够大横向能量的电子注与高频场的横向电场进行互作用,因此要对电子枪进行专门的设计。利用绝热压缩理论及相关的仿真软件对双阳极磁控注入电子枪进行了设计,得到了较好的电子注参数。所设计的电子枪能在工作电压80 kV、工作电流40 A 的条件下为170 GHz 基波回旋管提供所需的回旋电子注,其引导中心半径为8.27 mm,横纵速度比1.5。

  18. Backscattering of gyrotron radiation and short-wavelength turbulence during electron cyclotron resonance plasma heating in the L-2M stellarator

    Energy Technology Data Exchange (ETDEWEB)

    Batanov, G. M.; Borzosekov, V. D., E-mail: tinborz@gmail.com; Kovrizhnykh, L. M.; Kolik, L. V.; Konchekov, E. M.; Malakhov, D. V.; Petrov, A. E.; Sarksyan, K. A.; Skvortsova, N. N.; Stepakhin, V. D.; Kharchev, N. K. [Russian Academy of Sciences, Prokhorov General Physics Institute (Russian Federation)

    2013-06-15

    Backscattering of gyrotron radiation ({theta} = {pi}) by short-wavelength density fluctuations (k{sub Up-Tack} = 30 cm{sup -1}) in the plasma of the L-2M stellarator was studied under conditions of electron cyclotron resonance (ECR) plasma heating at the second harmonic of the electron gyrofrequency (75 GHz). The scattering of the O-wave emerging due to the splitting of the linearly polarized gyrotron radiation into the X- and O-waves was analyzed. The signal obtained after homodyne detection of scattered radiation is a result of interference of the reference signal, the quasi-steady component, and the fast oscillating component. The coefficients of reflection of the quasi-steady component, R{sub =}{sup 2}(Y), and fast oscillating component, R{sub {approx}}{sup 2}(Y), of scattered radiation are estimated. The growth of the R{sub {approx}}{sup 2}(Y) coefficient from 3.7 Multiplication-Sign 10{sup -4} to 5.2 Multiplication-Sign 10{sup -4} with increasing ECR heating power from 190 to 430 kW is found to correlate with the decrease in the energy lifetime from 1.9 to 1.46 ms. The relative density of short-wavelength fluctuations is estimated to be Left-Pointing-Angle-Bracket n{sub {approx}}{sup 2} Right-Pointing-Angle-Bracket / Left-Pointing-Angle-Bracket n{sub e}{sup 2} Right-Pointing-Angle-Bracket = 3 Multiplication-Sign 10{sup -7}. It is shown that the frequencies of short-wavelength fluctuations are in the range 10-150 kHz. The recorded short-wavelength fluctuations can be interpreted as structural turbulence, the energy of which comprises {approx}10% of the total fluctuations energy. Simulations of transport processes show that neoclassical heat fluxes are much smaller than anomalous ones. It is suggested that short-wavelength turbulence plays a decisive role in the anomalous heat transport.

  19. 94 GHz TE02模回旋管Vlasov模式变换器的设计与模拟%Design and Simulation of Vlasov Mode Converter for 94 GHz TE02 Mode Gyrotron

    Institute of Scientific and Technical Information of China (English)

    王斌; 杜朝海; 刘濮鲲; 耿志辉; 徐寿喜

    2011-01-01

    该文研究并设计了一个由Vlasov阶梯型开口辐射器、椭圆面反射器和抛物面反射器组成的TE02模回旋管准光模式变换器.首先采用几何光学研究了阶梯型开口辐射器、椭圆面反射器和抛物面反射器的具体形状,再利用矢量绕射理论分析了其工作过程,最后结合 94 GHz TE02模回旋管的具体参数,编写仿真程序详细讨论了工作模式在此模式变换器中的变换过程.模拟结果表明,94 GHz回旋管中的TE02模在输出窗处被转换为能量集中的准高斯波束,转换效率为78.35%.%The quasi-optical mode converter for the TE02 mode gyrotron, consisting of a Vlasov stepped-cut launcher,an elliptical reflector and a parabolic reflector, was designed, fabricated and studied. Firstly, the stepped-cut launcher, the elliptical reflector and the parabolic reflector were analytically evaluated with geometric optics. Next, the operation process of the converter was analyzed with vector diffra fion theory. And finally,operation of the mode conversion was simulated,based on the physical model of Vlasov mede converter for 94 GHz TE02 mode gyrotron. The simulated results show that the TE02 mode inside the 94 GHz gyrotron was converted into a higly Gaussian-like beam at the output window, and that the conversion efficiency was 78.35%.

  20. Observations of Regular Filamentary Plasma Arrays in High-Pressure Gas Breakdown by 1.5 MW, 110 GHz Gyrotron Pulses

    Science.gov (United States)

    Hidaka, Yoshiteru

    2008-11-01

    Formation of regular two-dimensional plasma filamentary arrays has been observed in long open-shuttered images of air breakdown at atmospheric pressure [Y. Hidaka et al., Phys. Rev. Lett. 100, 035003 (2008)]. The breakdown was generated by a focused linearly-polarized Gaussian beam from a 1.5-MW, 110-GHz gyrotron with a 3-microsecond pulse length. Each plasma filament is elongated in the electric field direction and separated roughly one-quarter wavelength from each other in the H-plane. The development of this array structure can be explained as a result of diffraction of the beam around the highly conductive filaments. The diffraction generates a new electric field profile in which a high intensity region emerges about a quarter wavelength upstream from an existing filament. A new plasma filament is likely to appear at the intensified spot. The same process continues and results in the formation of the observed array. Electromagnetic wave simulations that model plasma filaments as metallic posts agree quite well with the hypothesis above. With a nanoseconds-gated ICCD camera, we directly confirmed that only a few rows of the observed array are bright at any one moment, as well as that the light emitting region propagates towards the microwave source. Further experimental breakdown research has been carried out with nitrogen, helium, and SF6 at different pressures. Although each species exhibits qualitatively different structures, in general, a lumpy plasma at high pressures transforms into a more familiar, diffuse plasma as pressure is decreased. The propagation velocity of the ionization front has been also estimated both from the ICCD images and a photodiode array. The velocity is on the order of 10 km/s, and increases as the pressure decreases and the power density increases.

  1. L-型钙通道电流在D型钠尿肽抑制豚鼠胃动力中的作用%Role of L-type calcium current in DNP-induced inhibition of gastric motility of guinea pigs

    Institute of Scientific and Technical Information of China (English)

    郭莉; 李萍; 邱阳; 刘越坚; 贺守城; 法欣欣; 郭慧淑

    2013-01-01

    Objective To investigate the role of L-type calcium current in DNP-induced inhibition of gastric motility and its mechanism in gastric antral myocytes of guinea pigs. Methods The spontaneous contraction of gastric antral circular muscles of guinea pigs was recorded by a 4-channel physiograph. The whole-cell patch-clamp technique was used to record IBa as L-type calcium channel currents. Results DNP inhibited spontaneous contraction and exhibited a dose-dependent manner at the concentrations of 1 nmol/L, 10 nmol/L and 100 nmol/L, DNP inhibited spontaneous contraction (35.00 ±7.00)%, (54.00+8.00)%, (78. 00 ± 13. 00)% ; DNP suppressed IBa in a dose-dependant manner at the concentrations of 1 nmol/L, 10 nmol/L and 100 nmol/L,DNP inhibited IBa to (60. 12 ±2. 02)% , (57. 12 ±3. 02)% , and (42.12 ±3.16)% , respectively in gastric antral circular smooth muscle cells (SMCs) of guinea pigs. DNP-induced inhibition of IBa was partially blocked by LY83583, an inhibitor of guanylate cyclase, the inhibited amplitude from (67. 12 ±4.02) % to (88.03 ±4. 15) %. KT5823, a cGMP-dependent protein kinase (PKG) inhibitor, almost completely blocked DNP-induced inhibition of IBa. However, DNP-induced inhibition of IBa was potentiated by zaprinast, an inhibitor of cGMP-sensitive phosphodiesterase, the inhibited amplitude from (67.12 ±4.02)% to (53.00 ±4.23)%. Conclusions DNP significantly inhibits gastric motility in the gastric antrum of guinea pigs. DNP inhibits L-type calcium channel currents via pGC-cGMP-PKG-dependent signal pathway in gastric antral myocytes of guinea pigs.%目的 探讨L-型钙通道电流在D型钠尿肽(DNP)抑制豚鼠胃动力中的作用及机制.方法 制作豚鼠胃窦部环形肌肌条后,用多道生理记录仪记录环形肌自发性收缩活动;分离环形肌细胞后,用膜片钳记录细胞L-型钡电流(IBa),以IBa代表钙电流;观察不同抑制剂预处理后,10 nmol/L DNP对IBa的影响.结果 1、10、100 nmol/LDNP抑制豚鼠胃

  2. 170 GHz兆瓦级同轴回旋振荡管的分析计算%Analysis and calculation of a 170 GHz megawatt-level coaxial gyrotron

    Institute of Scientific and Technical Information of China (English)

    覃觅觅; 罗勇; 杨阔; 黄勇

    2014-01-01

    回旋管是最有希望应用于正在实施的国际热核实验反应堆计划的微波源器件,然而研究设计符合要求的回旋管还存在很多困难需要解决.对170 GHz兆瓦级光滑同轴回旋管的注-波互作用进行了研究.选取模式谱相对稀疏的TE31,12作为工作模式,利用Matlab编制源程序,计算了同轴回旋管的注-波耦合系数、起振电流.在考虑电子速度零散、腔壁电阻率和单模近似的基础上,对光滑同轴谐振腔的优化设计和注-波互作用进行了仿真,给出了磁场、电压、电流和内导体倾角等参量与回旋管效率的关系.结果表明,电压和磁场对回旋管效率影响较大,电子速度零散对回旋管效率影响较小,因而可降低电子枪的设计要求.此外,优化内导体倾角和同轴谐振腔结构参数可提高注-波互作用效率,降低电子速度零散对互作用效率的影响,获得了约50%的电子效率及1.7 MW输出功率.%Gyrotrons are the most promising microwave source devices that can be used in the International Thermonuclear Experimental Reactor, but there are many diffculties to be solved in study and design of gyrotrons to meet the require-ments. In this paper, the beam-wave interactions of a 170 GHz megawatt-level smooth-wall coaxial gyrotron are studied numerically. In order to attain high effciency and stable radiation, TE31,12 mode that lies in a relative sparse spectrum is selected as the operating mode, and the beam-wave coupling coeffcient and start oscillation current are calculated by a set of source codes developed by Matlab. Taking into account the electronic velocity spread and cavity wall resistivity, and based on a single-mode approximation, the optimization design and simulation of beam-wave interaction of a 170 GHz megawatt smooth-wall coaxial gyrotron have been fulfilled. The relationships between effciency and magnetic field, and the voltage, current, taper angle of insert, and other parameters are

  3. Controlador DNP3 para la CIAA

    OpenAIRE

    Tobar, Sebastián; Noguera, Joel; Taffernaberry, Juan Carlos; Mercado, Gustavo

    2016-01-01

    La CIAA [1] (Computadora Industrial Abierta Argentina) tiene las características necesarias para utilizarse como RTU (Remote Terminal Unit - Unidad Terminal Remota) en sistemas SCADA [2] (Supervisory Control And Data Acquisition – Supervisión Control y Adquisición de Datos). Sin embargo, una gran limitación para esta aplicación radica en que actualmente soporta un único protocolo de comunicación: Modbus. Si bien este protocolo es, probablemente, el más utilizado históricamente en la industria...

  4. Determinação de efedrinas em urina por cromatografia em fase gasosa (CG/DNP para o controle da dopagem no esporte Gas chromatographic method for the determination of ephedrines in urine for doping control purposes

    Directory of Open Access Journals (Sweden)

    Paula Rodrigues Garcia

    2005-09-01

    Full Text Available Efedrinas são aminas simpatomiméticas componentes de diversas especialidades farmacêuticas, utilizadas no tratamento de doenças respiratórias devido à sua ação descongestionante e broncodilatora. Atualmente, diversos produtos comercializados como suplementos nutricionais contêm efedrinas e são amplamente utilizados no meio esportivo, com o objetivo de facilitar a queima de gorduras e melhorar o desempenho. Entretanto, o uso indiscriminado destas substâncias pode acarretar série de efeitos tóxicos como hipertensão, taquicardia, cefaléia e tremores. Devido à sua ação psicoestimulante, foram incluídas na lista de substâncias proibidas nas atividades esportivas pelo Comitê Olímpico Internacional (COI e estabelecidas concentrações na urina para o controle da dopagem (efedrina e metilefedrina: 10 µg/mL. O presente trabalho teve como objetivo a validação de um método para quantificação de efedrinas, por cromatografia em fase gasosa acoplada a detetor de nitrogênio/fósforo (CG/DNP, em amostras de urina com a finalidade de controle da dopagem. O método consistiu em extração líquido-líquido e posterior derivação das efedrinas com anidrido trifluoroacético, e demonstrou ser simples e prático, apresentando linearidade nas faixas de concentração estudadas. Amostras de urina de voluntários que relataram uso de efedrinas foram submetidas à análise pelo método proposto.Ephedrines are sympathomimetic amines present in many pharmaceutical preparations used in the treatment of respiratory diseases due to their actions against broncospasm and congestion. Nowadays, several products sold as nutritional supplements contain ephedrines and are widely used in a diverse range of sports as weight loss aids and enhancement of athletic performance. However, the abuse of ephedrines may lead to a number of adverse effects including hypertension, headache, tachycardia and seizure. Due to their CNS stimulating action, ephedrines are

  5. 太阳光下TiO2/SiO2气凝胶复合光催化剂光催化降解2,4-二硝基酚%Solar photocatalytic degradation of 2,4-dinitrophenol (DNP) using TiO2/SiO2 aerogel composite photocatalysts

    Institute of Scientific and Technical Information of China (English)

    梁文珍; 王慧龙; 姜文凤

    2011-01-01

    以正硅酸乙酯(TEOS)为原料,采用溶胶-凝胶法(so1-ge1)和常压干燥法制备SiO2气凝胶,在此基础上,将硅气凝胶掺杂进入TiO2溶胶中制备出TiO2/SiO2气凝胶复合光催化剂.利用xRD、TEM和FI-IR等技术对其晶型、形貌和结构进行表征,研究了太阳光下TiO2/SiO2气凝胶复合光催化荆对2,4-二硝基苯酚(DNP)的光催化降解性能.结果表明,500℃焙烧后的TiO2/SiO2气凝胶复合材料对DNP溶液的吸附率和光降解率明显优于纯TiO2样品,加入7.5%(质量分数)SiO2气凝胶的复合光催化剂表现出最佳的光催化活性.根据Langmuir-Hinshelwood方程,在低浓度下光催化降解DNP的反应符合一级反应动力学.%Silica aerogels were synthesized by sol-gel technique at ambient pressure using tetraethyl orthosilioate. The TiO2/silica aerogel composite photocatalysts were prepared by doping silica aerogel into the nanosized TiO2 particles. The microstrueture and morphology of the photocatnlysts were characterized by XRD, TEM and FT-IR techniques. The photocatalytic degradation of 2,4-dinitrophenol (DNP) was investigated by using this novel TiO2/silica aerogel composite photocatalyst under solar light irradiation. The results showed that the highest photocatalytic activity was obtained when the composite sample was calcined at 500℃ with an optimal silica aerogel content of 7.5% (wt.). Compared to the pure TiO2 catalyst, the TiO2/silica aerogel composite photocatalyst showed much higher adsorption capacity and photocatalytic degradation efficiency for DNP. The photocatalytic reaction is discussed in terms of Langmuir-Hinshelwood model and it followed pseudo-first order kinetics at low concentration.

  6. Simulation study for measurement of horizontal wind profiles in the polar stratosphere and mesosphere using ground-based observations of ozone and carbon monoxide lines in the 230-250 GHz region

    Science.gov (United States)

    Newnham, David A.; Ford, George P.; Moffat-Griffin, Tracy; Pumphrey, Hugh C.

    2016-07-01

    Meteorological and atmospheric models are being extended up to 80 km altitude but there are very few observing techniques that can measure stratospheric-mesospheric winds at altitudes between 20 and 80 km to verify model datasets. Here we demonstrate the feasibility of horizontal wind profile measurements using ground-based passive millimetre-wave spectroradiometric observations of ozone lines centred at 231.28, 249.79, and 249.96 GHz. Vertical profiles of horizontal winds are retrieved from forward and inverse modelling simulations of the line-of-sight Doppler-shifted atmospheric emission lines above Halley station (75°37' S, 26°14' W), Antarctica. For a radiometer with a system temperature of 1400 K and 30 kHz spectral resolution observing the ozone 231.28 GHz line we estimate that 12 h zonal and meridional wind profiles could be determined over the altitude range 25-74 km in winter, and 28-66 km in summer. Height-dependent measurement uncertainties are in the range 3-8 m s-1 and vertical resolution ˜ 8-16 km. Under optimum observing conditions at Halley a temporal resolution of 1.5 h for measuring either zonal or meridional winds is possible, reducing to 0.5 h for a radiometer with a 700 K system temperature. Combining observations of the 231.28 GHz ozone line and the 230.54 GHz carbon monoxide line gives additional altitude coverage at 85 ± 12 km. The effects of clear-sky seasonal mean winter/summer conditions, zenith angle of the received atmospheric emission, and spectrometer frequency resolution on the altitude coverage, measurement uncertainty, and height and time resolution of the retrieved wind profiles have been determined.

  7. Solid-state dynamic nuclear polarization at 263 GHz: spectrometer design and experimental results†

    Science.gov (United States)

    Rosay, Melanie; Tometich, Leo; Pawsey, Shane; Bader, Reto; Schauwecker, Robert; Blank, Monica; Borchard, Philipp M.; Cauffman, Stephen R.; Felch, Kevin L.; Weber, Ralph T.; Temkin, Richard J.; Griffin, Robert G.; Maas, Werner E.

    2015-01-01

    Dynamic Nuclear Polarization (DNP) experiments transfer polarization from electron spins to nuclear spins with microwave irradiation of the electron spins for enhanced sensitivity in nuclear magnetic resonance (NMR) spectroscopy. Design and testing of a spectrometer for magic angle spinning (MAS) DNP experiments at 263 GHz microwave frequency, 400 MHz 1H frequency is described. Microwaves are generated by a novel continuous-wave gyrotron, transmitted to the NMR probe via a transmission line, and irradiated on a 3.2 mm rotor for MAS DNP experiments. DNP signal enhancements of up to 80 have been measured at 95 K on urea and proline in water–glycerol with the biradical polarizing agent TOTAPOL. We characterize the experimental parameters affecting the DNP efficiency: the magnetic field dependence, temperature dependence and polarization build-up times, microwave power dependence, sample heating effects, and spinning frequency dependence of the DNP signal enhancement. Stable system operation, including DNP performance, is also demonstrated over a 36 h period. PMID:20449524

  8. PhD or DNP: planning for doctoral nursing education.

    Science.gov (United States)

    Bednash, Geraldine; Breslin, Eileen T; Kirschling, Jane M; Rosseter, Robert J

    2014-10-01

    Leading authorities from inside and outside of nursing are calling for a rapid increase in the number of nurses holding doctoral degrees. More nurses with the terminal degree are needed to serve as Advanced Practice Registered Nurses, assume faculty roles, embark on research careers, and pursue top leadership positions. Today's prospective nursing student can choose from doctoral programs focused on research or practice. The authors explore the differences in these degree options, expectations for students enrolled in these programs, key questions to ask when selecting a degree type, and the career choices available to doctorally-prepared nurses, including faculty positions. PMID:25248773

  9. Analyses of advanced concepts in multi-stage gyro-amplifiers and startup in high power gyro-oscillators

    Science.gov (United States)

    Sinitsyn, Oleksandr V.

    Gyrotrons are well recognized sources of high-power coherent electromagnetic radiation. The power that gyrotrons can radiate in the millimeter- and submillimeter-wavelength regions exceeds the power of classical microwave tubes by many orders of magnitude. In this work, the author considers some problems related to the operation of gyro-devices and methods of their solution. In particular, the self-excitation conditions for parasitic backward waves and effect of distributed losses on the small-signal gain of gyro-TWTs are analyzed. The corresponding small-signal theory describing two-stage gyro-traveling-wave tubes (gyro-TWTs) with the first stage having distributed losses is presented. The theory is illustrated by using it for the description of operation of a Ka-band gyro-TWT designed at the Naval Research Laboratory. Also, the results of nonlinear studies of this tube are presented and compared with the ones obtained by the use of MAGY, a multi-frequency, self-consistent code developed at the University of Maryland. An attempt to build a large signal theory of gyro-TWTs with tapered geometry and magnetic field profile is made and first results are obtained for a 250 GHz gyro-TWT. A comparative small-signal analysis of conventional four-cavity and three-stage clustered-cavity gyroklystrons is performed. The corresponding point-gap models for these devices are presented. The efficiency, gain, bandwidth and gain-bandwidth product are analyzed for each scheme. Advantages of the clustered-cavity over the conventional design are discussed. The startup scenarios in high-power gyrotrons and the most important physical effects associated with them are considered. The work presents the results of startup simulations for a 140 GHz, MW-class gyrotron developed by Communications and Power Industries (CPI) for electron-cyclotron resonance heating (ECRH) and current drive experiments on the "Wendelstein 7-X" stellarator plasma. Also presented are the results for a 110 GHz, 1

  10. Construction of a 35 GHz 100 kW gyrotron

    International Nuclear Information System (INIS)

    In this work a description of a 35 GHz 100 kW gyrocon is described which is under construction at the National Space Research Institute Plasma Laboratory. Project conceptual aspects are emphasized, specifically high current density thermionic cathodes, high time and spatial resolution intense magnetic fields generation, high-vacuum systems, techniques of ceramic-metal sealing, and high-voltage electrical modulator circuits. (author). 8 refs., 9 figs., 1 tab

  11. Structural analysis of a signal peptide inside the ribosome tunnel by DNP MAS NMR.

    Science.gov (United States)

    Lange, Sascha; Franks, W Trent; Rajagopalan, Nandhakishore; Döring, Kristina; Geiger, Michel A; Linden, Arne; van Rossum, Barth-Jan; Kramer, Günter; Bukau, Bernd; Oschkinat, Hartmut

    2016-08-01

    Proteins are synthesized in cells by ribosomes and, in parallel, prepared for folding or targeting. While ribosomal protein synthesis is progressing, the nascent chain exposes amino-terminal signal sequences or transmembrane domains that mediate interactions with specific interaction partners, such as the signal recognition particle (SRP), the SecA-adenosine triphosphatase, or the trigger factor. These binding events can set the course for folding in the cytoplasm and translocation across or insertion into membranes. A distinction of the respective pathways depends largely on the hydrophobicity of the recognition sequence. Hydrophobic transmembrane domains stabilize SRP binding, whereas less hydrophobic signal sequences, typical for periplasmic and outer membrane proteins, stimulate SecA binding and disfavor SRP interactions. In this context, the formation of helical structures of signal peptides within the ribosome was considered to be an important factor. We applied dynamic nuclear polarization magic-angle spinning nuclear magnetic resonance to investigate the conformational states of the disulfide oxidoreductase A (DsbA) signal peptide stalled within the exit tunnel of the ribosome. Our results suggest that the nascent chain comprising the DsbA signal sequence adopts an extended structure in the ribosome with only minor populations of helical structure. PMID:27551685

  12. Health Informatics Competencies, Workforce and the DNP: Why Connect These 'Dots'?

    Science.gov (United States)

    Brixey, Juliana J

    2016-01-01

    This panel will provide the perspectives of nurse informatics experts on the development of informatics education integrating health information technology (HIT) and immersive simulation. The panel will also address student and provider access to the electronic health record (EHR) for educational purposes. This panel examines the education and preparation of students and practicing nurses to meaningfully use EHRs. The target audience is clinicians, educators, trainers, students and those interested in the meaningful use of EHRs and achievement of the Informatics competencies defined by AACN and TIGER. PMID:27332329

  13. UTAUT2 Based Predictions of Factors Influencing the Technology Acceptance of Phablets by DNP

    OpenAIRE

    Chi-Yo Huang; Yu-Sheng Kao

    2015-01-01

    The smart mobile devices have emerged during the past decade and have become one of the most dominant consumer electronic products. Therefore, exploring and understanding the factors which can influence the acceptance of novel mobile technology have become the essential task for the vendors and distributors of mobile devices. The Phablets, integrated smart devices combining the functionality and characteristics of both tablet PCs and smart phones, have gradually become possible alternatives f...

  14. Cryogenic solid state NMR studies of fibrils of the Alzheimer’s disease amyloid-β peptide: perspectives for DNP

    International Nuclear Information System (INIS)

    Dynamic Nuclear Polarization solid-state NMR holds the potential to enable a dramatic increase in sensitivity by exploiting the large magnetic moment of the electron. However, applications to biological solids are hampered in uniformly isotopically enriched biomacromolecules due to line broadening which yields a limited spectral resolution at cryogenic temperatures. We show here that high magnetic fields allow to overcome the broadening of resonance lines often experienced at liquid nitrogen temperatures. For a fibril sample of the Alzheimer’s disease β-amyloid peptide, we find similar line widths at low temperature and at room temperature. The presented results open new perspectives for structural investigations in the solid-state

  15. New Radiation Input/Output Systems for Millimeter-Wave Gyrotron Traveling-Wave Tubes

    Science.gov (United States)

    Denisov, G. G.; Bogdashov, A. A.; Gachev, I. G.; Mishakin, S. V.; Samsonov, S. V.

    2016-03-01

    We consider in detail the method allowing one to input and output the microwave radiation produced by an elecrovacuum amplifier through the same barrier window, which was proposed earlier, in the context of its application in a traveling-wave tube based on a waveguide with a helically corrugated surface. Special attention is given to the splitter of differently polarized radiation, and the results of studying this splitter at wavelengths of about 6 and 1 mm theoretically and experimentally are presented.

  16. Klystrons, traveling wave tubes, magnetrons, crossed-field amplifiers, and gyrotrons

    CERN Document Server

    Gilmour, A S

    2011-01-01

    Microwave tubes are vacuum electron devices used for the generation and amplification of radio frequencies in the microwave range. An established technology area, the use of tubes remains essential in the field today for high-power applications. The culmination of the author's 50 years of industry experience, this authoritative resource offers you a thorough understanding of the operations and major classes of microwave tubes.Minimizing the use of advanced mathematics, the book places emphasis on clear qualitative explanations of phenomena. This practical reference serves as an excellent intro

  17. Solid effect in magic angle spinning dynamic nuclear polarization

    Science.gov (United States)

    Corzilius, Björn; Smith, Albert A.; Griffin, Robert G.

    2012-08-01

    For over five decades, the solid effect (SE) has been heavily utilized as a mechanism for performing dynamic nuclear polarization (DNP). Nevertheless, it has not found widespread application in contemporary, high magnetic field DNP experiments because SE enhancements display an ω _0 ^{ - 2} field dependence. In particular, for nominally forbidden zero and double quantum SE transitions to be partially allowed, it is necessary for mixing of adjacent nuclear spin states to occur, and this leads to the observed field dependence. However, recently we have improved our instrumentation and report here an enhancement of ɛ = 91 obtained with the organic radical trityl (OX063) in magic angle spinning experiments performed at 5 T and 80 K. This is a factor of 6-7 higher than previous values in the literature under similar conditions. Because the solid effect depends strongly on the microwave field strength, we attribute this large enhancement to larger microwave field strengths inside the sample volume, achieved with more efficient coupling of the gyrotron to the sample chamber. In addition, we develop a theoretical model to explain the dependence of the buildup rate of enhanced nuclear polarization and the steady-state enhancement on the microwave power. Buildup times and enhancements were measured as a function of 1H concentration for both trityl and Gd-DOTA. Comparison of the results indicates that for trityl the initial polarization step is the slower, rate-determining step. However, for Gd-DOTA the spread of nuclear polarization via homonuclear 1H spin diffusion is rate-limiting. Finally, we discuss the applicability of the solid effect at fields > 5 T and the requirements to address the unfavorable field dependence of the solid effect.

  18. Cryogenic solid state NMR studies of fibrils of the Alzheimer's disease amyloid-{beta} peptide: perspectives for DNP

    Energy Technology Data Exchange (ETDEWEB)

    Lopez del Amo, Juan-Miguel [CIC Energigune (Spain); Schneider, Dennis [Bruker BioSpin (Germany); Loquet, Antoine; Lange, Adam [Max-Planck-Institut fuer Biophysikalische Chemie (Germany); Reif, Bernd, E-mail: reif@tum.de [Deutsches Forschungszentrum fuer Gesundheit und Umwelt, Helmholtz-Zentrum Muenchen (HMGU) (Germany)

    2013-08-15

    Dynamic Nuclear Polarization solid-state NMR holds the potential to enable a dramatic increase in sensitivity by exploiting the large magnetic moment of the electron. However, applications to biological solids are hampered in uniformly isotopically enriched biomacromolecules due to line broadening which yields a limited spectral resolution at cryogenic temperatures. We show here that high magnetic fields allow to overcome the broadening of resonance lines often experienced at liquid nitrogen temperatures. For a fibril sample of the Alzheimer's disease {beta}-amyloid peptide, we find similar line widths at low temperature and at room temperature. The presented results open new perspectives for structural investigations in the solid-state.

  19. Strategy-aligned fuzzy approach for market segment evaluation and selection: a modular decision support system by dynamic network process (DNP)

    Science.gov (United States)

    Mohammadi Nasrabadi, Ali; Hosseinpour, Mohammad Hossein; Ebrahimnejad, Sadoullah

    2013-05-01

    In competitive markets, market segmentation is a critical point of business, and it can be used as a generic strategy. In each segment, strategies lead companies to their targets; thus, segment selection and the application of the appropriate strategies over time are very important to achieve successful business. This paper aims to model a strategy-aligned fuzzy approach to market segment evaluation and selection. A modular decision support system (DSS) is developed to select an optimum segment with its appropriate strategies. The suggested DSS has two main modules. The first one is SPACE matrix which indicates the risk of each segment. Also, it determines the long-term strategies. The second module finds the most preferred segment-strategies over time. Dynamic network process is applied to prioritize segment-strategies according to five competitive force factors. There is vagueness in pairwise comparisons, and this vagueness has been modeled using fuzzy concepts. To clarify, an example is illustrated by a case study in Iran's coffee market. The results show that success possibility of segments could be different, and choosing the best ones could help companies to be sure in developing their business. Moreover, changing the priority of strategies over time indicates the importance of long-term planning. This fact has been supported by a case study on strategic priority difference in short- and long-term consideration.

  20. Case study of the failure of supercritical water oxidation reactor tubing during the treatment of 2,4 DNP with ammonium sulphate

    International Nuclear Information System (INIS)

    During the process of Supercritical Water Oxidation (SCWO) organic chemical streams are oxidized at high temperature and pressure, typically in excess of 647 K and 22.1 MPa. Due to high operating temperatures and pressures severely corrosive environments often ensue and eventually lead to SCWO reactor tube failures. This case study looked at one such failure of Alloy 625 (61Ni-21.5Cr-9Mo) tubing which occurred at the UBC/NORAM SCWO pilot plant while treating a feed of waste water containing 2.4 wt% 2,4 dinitrophenolate, 2% ammonium sulphate and 6% excess ammonia. Although the feed pH was approximately 9 and therefore not expected to be corrosive, in fact the tube failed when exposed to this feed (with oxygen) for a period of about 1 hour at 650-655 K. Through the examination of the ensuing thermodynamic system as well as SEM and Optical Microscope analysis of the ruptured portions of tubing, it was found that the addition of ammonium sulphate to the treated media caused rapid failure due to de-alloying. Findings show that the high sub-critical temperature and high density of the feed water at failure points, as well as the corrosion morphology are consistent with attack by ammonia. The formation of a stable soluble nickel-ammine phase is suspected. (author)

  1. An all MMIC Replacement for Gunn Diode Oscillators Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this Phase II project is to develop and demonstrate a compact and reliable oscillator technology for the frequency band from 100 ? 250 GHz for use...

  2. Josephson junction spectrum analyzer for millimeter and submillimeter wavelengths

    Energy Technology Data Exchange (ETDEWEB)

    Larkin, S.Y.; Anischenko, S.E.; Khabayev, P.V. [State Research Center, Kiev (Ukraine)

    1994-12-31

    A prototype of the Josephson-effect spectrum analyzer developed for the millimeter-wave band is described. The measurement results for spectra obtained in the frequency band from 50 to 250 GHz are presented.

  3. Comparison of in vitro immunogenicity, tolerogenicity and mitogenicity of dinitrophenyl-levan conjugates with varying epitope density.

    Science.gov (United States)

    Desaymard, C; Ivanyi, L

    1976-01-01

    The mitogenicity, immunogenicity and tolerogenicity of various DNP-levan (DNP-LE) conjugates were compared using in vitro methods. Anti-DNP antibody synthesis induced by DNP-LE conjugates was related to the epitope density of DNP, BUT WAS NOT AFFECTED BY Macrophage dependent and was not influenced by the degree of hapten conjugation. These results imply that mitogenicity of an antigen is not necessarily related to the specific triggering of B cells. PMID:58831

  4. Study on High Frequency Gyrotron Microwave Sintering of Nanoceramics%高频回旋管微波烧结纳米陶瓷研究

    Institute of Scientific and Technical Information of China (English)

    范瑛; 韦力凡; 丰杰; 谭云; 鞠炳全; 张卫庄

    2004-01-01

    在高频回旋管微波烧结系统上进行纳米陶瓷烧结研究,制备出氧化锆单元及二元纳米陶瓷样品,对不同烧结工艺制备出的样品做了密度、硬度测试,利用XRD和扫描电镜分析陶瓷样品晶粒特性,以摸索适宜的烧结工艺.探讨了高频回旋管微波烧结纳米陶瓷的可行性.

  5. ADSORPTION, DEGRADATION, AND PLANT AVAILABILITY OF 2,4-DINITROPHENOL IN SLUDGE-AMENDED CALCAREOUS SOILS

    Science.gov (United States)

    Dinitrophenol (DNP) is a moderately weak acid that is expected to be highly labile (leachable and plant available) in high-pH soils. The adsorption and degradation behavior of DNP in two sludge-amended, calcareous soils was determined and used to explain DNP uptake by plants grow...

  6. Solid state NMR based structural biology enhanced by dynamic nuclear polarization

    NARCIS (Netherlands)

    Koers, E.J.

    2014-01-01

    While DNP has a history that goes back 60 years, high-field DNP is a young and rapidly developing field. Applications of DNP on proteins have been published from 1997 on, but stayed of limited use until a few years ago. The possibilities have not been fully explored. Two applications in the field of

  7. Determinação de efedrinas em urina por cromatografia em fase gasosa (CG/DNP) para o controle da dopagem no esporte Gas chromatographic method for the determination of ephedrines in urine for doping control purposes

    OpenAIRE

    Paula Rodrigues Garcia; Mauricio Yonamine; Regina Lúcia de Moraes Moreau

    2005-01-01

    Efedrinas são aminas simpatomiméticas componentes de diversas especialidades farmacêuticas, utilizadas no tratamento de doenças respiratórias devido à sua ação descongestionante e broncodilatora. Atualmente, diversos produtos comercializados como suplementos nutricionais contêm efedrinas e são amplamente utilizados no meio esportivo, com o objetivo de facilitar a queima de gorduras e melhorar o desempenho. Entretanto, o uso indiscriminado destas substâncias pode acarretar série de efeitos tóx...

  8. A versatile and modular quasi optics-based 200GHz dual dynamic nuclear polarization and electron paramagnetic resonance instrument.

    Science.gov (United States)

    Siaw, Ting Ann; Leavesley, Alisa; Lund, Alicia; Kaminker, Ilia; Han, Songi

    2016-03-01

    Solid-state dynamic nuclear polarization (DNP) at higher magnetic fields (>3T) and cryogenic temperatures (∼ 2-90K) has gained enormous interest and seen major technological advances as an NMR signal enhancing technique. Still, the current state of the art DNP operation is not at a state at which sample and freezing conditions can be rationally chosen and the DNP performance predicted a priori, but relies on purely empirical approaches. An important step towards rational optimization of DNP conditions is to have access to DNP instrumental capabilities to diagnose DNP performance and elucidate DNP mechanisms. The desired diagnoses include the measurement of the "DNP power curve", i.e. the microwave (MW) power dependence of DNP enhancement, the "DNP spectrum", i.e. the MW frequency dependence of DNP enhancement, the electron paramagnetic resonance (EPR) spectrum, and the saturation and spectral diffusion properties of the EPR spectrum upon prolonged MW irradiation typical of continuous wave (CW) DNP, as well as various electron and nuclear spin relaxation parameters. Even basic measurements of these DNP parameters require versatile instrumentation at high magnetic fields not commercially available to date. In this article, we describe the detailed design of such a DNP instrument, powered by a solid-state MW source that is tunable between 193 and 201 GHz and outputs up to 140 mW of MW power. The quality and pathway of the transmitted and reflected MWs is controlled by a quasi-optics (QO) bridge and a corrugated waveguide, where the latter couples the MW from an open-space QO bridge to the sample located inside the superconducting magnet and vice versa. Crucially, the versatility of the solid-state MW source enables the automated acquisition of frequency swept DNP spectra, DNP power curves, the diagnosis of MW power and transmission, and frequency swept continuous wave (CW) and pulsed EPR experiments. The flexibility of the DNP instrument centered around the QO MW

  9. A versatile and modular quasi optics-based 200 GHz dual dynamic nuclear polarization and electron paramagnetic resonance instrument

    Science.gov (United States)

    Siaw, Ting Ann; Leavesley, Alisa; Lund, Alicia; Kaminker, Ilia; Han, Songi

    2016-03-01

    Solid-state dynamic nuclear polarization (DNP) at higher magnetic fields (>3 T) and cryogenic temperatures (∼2-90 K) has gained enormous interest and seen major technological advances as an NMR signal enhancing technique. Still, the current state of the art DNP operation is not at a state at which sample and freezing conditions can be rationally chosen and the DNP performance predicted a priori, but relies on purely empirical approaches. An important step towards rational optimization of DNP conditions is to have access to DNP instrumental capabilities to diagnose DNP performance and elucidate DNP mechanisms. The desired diagnoses include the measurement of the "DNP power curve", i.e. the microwave (MW) power dependence of DNP enhancement, the "DNP spectrum", i.e. the MW frequency dependence of DNP enhancement, the electron paramagnetic resonance (EPR) spectrum, and the saturation and spectral diffusion properties of the EPR spectrum upon prolonged MW irradiation typical of continuous wave (CW) DNP, as well as various electron and nuclear spin relaxation parameters. Even basic measurements of these DNP parameters require versatile instrumentation at high magnetic fields not commercially available to date. In this article, we describe the detailed design of such a DNP instrument, powered by a solid-state MW source that is tunable between 193 and 201 GHz and outputs up to 140 mW of MW power. The quality and pathway of the transmitted and reflected MWs is controlled by a quasi-optics (QO) bridge and a corrugated waveguide, where the latter couples the MW from an open-space QO bridge to the sample located inside the superconducting magnet and vice versa. Crucially, the versatility of the solid-state MW source enables the automated acquisition of frequency swept DNP spectra, DNP power curves, the diagnosis of MW power and transmission, and frequency swept continuous wave (CW) and pulsed EPR experiments. The flexibility of the DNP instrument centered around the QO MW

  10. Synthesis of Insensitive N-2,4-dinitrophenyl-N1-nitroguanidine

    Science.gov (United States)

    Warner, Kirstin F.; Bellitto, Victor J.; Sorensen, Daniel N.; Remmers, Daniel L.

    2016-10-01

    A new, insensitive nitroguanidyl functionalized nitrogen-rich material derived from 2,4-dinitrophenyl derivative was synthesized. N-2,4-dinitrophenyl-N1-nitroguanidine (DNP-NQ) has a crystal density of 1.74 g/cm3. The synthesis and properties of DNP-NQ are described. DNP-NQ was characterized by nuclear magnetic resonance (NMR), infrared spectroscopy, and gas pycnometry. Thermal properties were studied by differential scanning calorimetry (DSC). Results from small-scale sensitivity tests indicate that DNP-NQ is less sensitive than Cyclotrimethylenetrinitramine (RDX). DNP-NQ can be prepared in high yield.

  11. Separation by column chromatography of cells active in delayed-onset hypersensitivities.

    Science.gov (United States)

    Godfrey, H P; Gell, P G

    1976-01-01

    Lymph node cells from guinea-pigs contact sensitive to 1-thiocyamo-2,4-dinitrobenzene have been fractionated by affinity chromatography over modified polyacrylamide beads. Cells mediating lymphokine release in response to active sensitizer were depleted only by chromatography over dinitrophyenyl (DNP) containing substrates and could be specifically eluted with DNP-glycine. DNP rosette-forming cells (RFC) were equally well depleted by chromatography using either DNP or trinitrophenyl containing materials but could not be eluted from the columns by DNP-glycine. While the antigen receptors of cells mediating the release of macrophage agglutination factor in response to DNP-containing antigens and of DNP-RFC were found to be hapten-specific, their specificity was shown to differ using chromatography over trinitrophenyl containing polyacrylamide. PMID:776818

  12. Observation of small sub-pulses out of the delayed-interference signal-wavelength converter

    DEFF Research Database (Denmark)

    Sakaguchi, J.; Nielsen, Mads Lønstrup; Ohira, T.;

    2005-01-01

    . In this work, we have experimentally verified the generation of such pulses and its mechanism. In the experiments we used 3.8-ps-long 1.56-mu m input pulses with repetition frequencies from 12.5 to 25.0 GHz and a cross-correlation monitoring system with a time resolution of approximately 2 ps....

  13. Spin-mapping of coal structures with ESE and ENDOR

    Energy Technology Data Exchange (ETDEWEB)

    Belford, R.L.; Clarkson, R.B.

    1990-12-01

    To ENDOR and ESE we have added another advanced EPR technique. VHF-EPR, as a tool with which to observe coal molecular structure, especially organic sulfur. We have constructed a unique VHF EPR instrument operating at the W-band (96 Ghz), one of only two such instruments in the world, and the only one studying coal. We are employing this instrument, as well as collaborating with scientists at Cornell University, who have a 250 GHz spectrometer, to develop a clearer understanding of the relationships between the VHF EPR spectra we observe from Illinois coal and the organic sulfur species present in it. Efforts in this quarter focussed on three area: recruitment of personnel (especially a new postdoctoral fellow) to join the coal research team work on improving the W-band spectrometer, and studies of vitrinite, sporinite, and fusinite macerals at G-band (250 GHz). All three areas have shown good progress. This report will discuss in detail the main features of the W-band instrument, stressing its unique engineering features as well as comparing it to the few other instruments in the world operating in the VHF frequency range (90--250 GHz). Preliminary analysis of the 250 GHz data on macerals obtained by density gradient centrifugation from an Illinois {number sign}6 coal gives the first indication that at the very highest frequencies, there may be a separation of the heteroatom VHF EPR signals into a sulfur and on oxygen-containing component. 15 refs., 9 figs., 1 tab.

  14. Ech System on the Diii-D Tokamak

    Science.gov (United States)

    Gorelov, I. A.; Lohr, J.; Cengher, M.; Ponce, D.

    2009-04-01

    A significant upgrade to the 110 GHz DIII-D ECH system was completed last year. Two additional Communication and Power Industries (CPI) diode gyrotrons were installed and tested to half the designed pulse length of 10 s. For the 2008 experimental campaign, the DIII-D system comprised five long pulse CPI gyrotrons. One additional high voltage power supply is being tested to support operation of up to 6 gyrotrons simultaneously at full parameters. The five gyrotrons in operation have chemical-vapor-deposition (CVD) diamond windows that are monitored by infrared camera during full parameter testing and operation during plasma experiments. A sixth CPI gyrotron has been repaired after collector failure and is being conditioned for high power at DIII-D. New equipment for gyrotron collector heat load monitoring was tested and used to measure the collector power deposition profile. A new fast fault processing system based on FPGA technology is being commissioned.

  15. State-of-the-art of high power gyro-devices and free electron masers 1994

    International Nuclear Information System (INIS)

    At present, gyrotron oscillators are mainly used as high power millimeter wave sources for electron cyclotron resonance heating (ECRH) and diagnostics of magnetically confined plasmas for generation of energy by controlled thermonuclear fusion. 140 GHz gyrotrons with output power Pout=0.54 MW, pulse length τ=3.0 s and efficiency η=42% are commercially available. Total efficiencies around 50% have been achieved using single-stage depressed collectors. Diagnostic gyrotrons deliver Pout=40 kW with τ=40 μs at frequencies up to 650 GHz (η≥4%). Recently, gyrotron oscillators have also been successfully used in material processing and plasma chemistry. Such technological applications require gyrotrons with the following parameters: f≥24 GHz, Pout=10-50 kW, CW, η≥30%. This paper reports on achievements and problems related to the development of very high power mm-wave gyrotrons for long pulse or CW operation and describes the microwave technological pecularities of the different development steps. In addition, this work gives a short overview of the present development of gyrotrons for technological applications, relativistic gyrotrons, quasi-optical gyrotrons, cyclotron autoresonance masers (CARMs), gyro klystrons, gyro-TWT amplifiers, gyrotwystron amplifiers, gyro-BWO's, peniotrons and free electron masers (FEMs). The most impressive FEM output parameters are: Pout=2 GW, τ=20 ns, η=13% at 140 GHz (LLNL) and Pout=15 kW, τ=20 μs, η=5% in the range from 120 to 900 GHz (UCSB). (orig.)

  16. Dinitrosopiperazine-Mediated Phosphorylated-Proteins Are Involved in Nasopharyngeal Carcinoma Metastasis

    Directory of Open Access Journals (Sweden)

    Gongjun Tan

    2014-11-01

    Full Text Available N,N'-dinitrosopiperazine (DNP with organ specificity for nasopharyngeal epithelium, is involved in nasopharyngeal carcinoma (NPC metastasis, though its mechanism is unclear. To reveal the pathogenesis of DNP-induced metastasis, immunoprecipitation was used to identify DNP-mediated phosphoproteins. DNP-mediated NPC cell line (6-10B motility and invasion was confirmed. Twenty-six phosphoproteins were increased at least 1.5-fold following DNP exposure. Changes in the expression levels of selected phosphoproteins were verified by Western-blotting analysis. DNP treatment altered the phosphorylation of ezrin (threonine 567, vimentin (serine 55, stathmin (serine 25 and STAT3 (serine 727. Furthermore, it was shown that DNP-dependent metastasis is mediated in part through ezrin at threonine 567, as DNP-mediated metastasis was decreased when threonine 567 of ezrin was mutated. Strikingly, NPC metastatic tumors exhibited a higher expression of phosphorylated-ezrin at threonine 567 than the primary tumors. These findings provide novel insight into DNP-induced NPC metastasis and may contribute to a better understanding of the metastatic mechanisms of NPC tumors.

  17. Design of pill-box output window for high power Q-band gyrotron traveling wave tube%Q波段回旋行波管新型盒型输出窗的设计

    Institute of Scientific and Technical Information of China (English)

    陈辉; 王丽; 罗勇; 唐勇

    2015-01-01

    利用等效电路理论,初步设计了窗片厚度为1.32 mm的回旋行波管盒型输出窗,再加入感性膜片,更改窗片形状,最终设计出了能承受25 kW平均功率、相对带宽达到14%、窗片厚度达到1.7 mm的Q波段新型宽频带回旋行波管盒型输出窗;采用高频软件HFSS与有限元分析软件ANSYS协同仿真的新方法对回旋行波管盒型窗进行热特性研究表明,盒型窗理论上功率容量达到62 kW平均功率,说明输出窗窗片承受25 kW平均功率的可行性,窗片中心与边缘的温差为66℃,没有达到陶瓷窗片的临界温差158℃,验证了新型盒型窗设计的合理性.

  18. Status of the new multi-frequency ECRH system for ASDEX Upgrade

    DEFF Research Database (Denmark)

    Wagner, D.; Grünwald, G.; Leuterer, F.;

    2008-01-01

    Currently, a new multi-frequency ECRH system is under construction at the ASDEX Upgrade tokamak experiment. This system employs, for the first time in a fusion device, multi-frequency gyrotrons, step-tunable in the range 105-140 GHz. The first two gyrotrons, working at 105 and 140 GHz, were insta...

  19. The DIII-D 3 MW, 110 GHz ECH system

    Science.gov (United States)

    Callis, R. W.; Lohr, J.; Ponce, D.; O'Neill, R. C.; Prater, R.; Luce, T. C.

    1999-09-01

    Three 110 GHz gyrotrons with nominal output power of 1 MW each have been installed and are operational on the DIII-D tokamak. One gyrotron is built by Gycom and has a nominal rating of 1 MW and a 2 s pulse length, with the pulse length being determined by the maximum temperature allowed on the edge cooled Boron Nitride window. The second and third gyrotrons were built by Communications and Power Industries (CPI). The first CPI gyrotron uses a double disc FC-75 cooled sapphire window which has a pulse length rating of 0.8 s at 1 MW, 2 s at 0.5 MW and 10 s at 0.35 MW. The second CPI gyrotron, utilizes a single disc chemical-vapor-deposition diamond window, that employs water cooling around the edge of the disc. Calculation predict that the diamond window should be capable of full 1 MW cw operation. All gyrotrons are connected to the tokamak by a low-loss-windowless evacuated transmission line using circular corrugated waveguide for propagation in the HE11 mode. Each waveguide system incorporates a two mirror launcher which can steer the rf beam poloidally from the center to the outer edge of the plasma. Central current drive experiments with the two gyrotrons with 1.5 MW of injected power drove about 0.17 MA. Results from using the three gyrotron systems will be reported as well as the plans to upgrade the system to 6 MW.

  20. State-of-the-art of high power gyro-devices and free electron masers

    International Nuclear Information System (INIS)

    At present, gyrotron oscillators are mainly used as high power millimeter wave sources for electron cyclotron resonance heating (ECRH) and diagnostics of magnetically confined plasmas for generation of energy by controlled thermonuclear fusion. 140 GHz gyrotrons with output power Pout = 0.58 MW, pulse length τ = 2.0 s and efficiency η = 34% are commercially available. Diagnostic gyrotrons deliver Pout = 40 kW with τ = 40 μs at frequencies up to 650 GHz (η ≥ 4%). Recently, gyrotron oscillators have also been successfully used in material processing and plasma chemistry. Such technological applications require gyrotrons with the following parameters: f ≥ 28 GHz, Pout = 10-30 kW, CW, η ≥ 30%. This paper reports on achievements and problems related to the development of very high power mm-wave gyrotrons for long pulse or CW operation and describes the microwave technological pecularities of the different development steps. In addition, this work gives a short overview of the present development of gyrotrons for technological applications, quasi-optical gyrotrons, cyclotron autoresonance masers (CARMs), gyro-klystrons, gyro-TWT amplifiers, gyro-BWO's and free electron masers (FEMs). The most impressive FEM output parameters are: Pout = 2 GW, τ = 20 ns, η = 13% at 140 GHz (LLNL) and Pout = 15 kW, τ = 20 μs, η = 5% in the range from 120 to 900 GHz (UCSB). (orig.)

  1. State-of-the-art of high power gyro-devices and free electron masers. Update 2005

    International Nuclear Information System (INIS)

    Gyrotron oscillators (gyromonotrons) are mainly used as high power millimeter wave sources for electron cyclotron resonance heating (ECRH), electron cyclotron current drive (ECCD), stability control and diagnostics of magnetically confined plasmas for generation of energy by controlled thermonuclear fusion. The maximum pulse length of commercially available 140 GHz, megawatt-class gyrotrons employing synthetic diamond output windows is 30 minutes (CPI and European FZK-CRPP-CEA-TED collaboration). The world record parameters of the European 140 GHz gyrotron are: 0.92 MW output power at 30 min. pulse duration, 97.5% Gaussian mode purity and 43% efficiency, employing a single-stage depressed collector for energy recovery. This results in an energy content of 1.66 GJ. A maximum output power of 1.2 MW in 4.1 s pulses was generated with the JAERI-TOSHIBA 110 GHz gyrotron. The Russian and the Japan 170 GHz ITER gyrotrons achieved 0.5 MW with pulse durations of 80 s and 500 s, respectively. Diagnostic gyrotrons deliver Pout=40 kW with τ=40 μs at frequencies up to 650 GHz (η=4%). Gyrotron oscillators have also been successfully used in materials processing. Such technological applications require gyrotrons with the following parameters: f≥24 GHz, Pout=4-50 kW, CW, η≥30%. This paper gives an update of the experimental achievements related to the development of high power gyrotron oscillators for long pulse or CW operation and pulsed gyrotrons for plasma diagnostics. In addition, this work gives a short overview of the present development status of coaxial-cavity gyrotrons, gyrotrons for technological applications, relativistic gyrotrons, quasi-optical gyrotrons, fast- and slow-wave cyclotron autoresonance masers (CARMs), gyroklystrons, gyro-TWT amplifiers, gyrotwystron amplifiers, gyro-BWO's, gyropeniotrons, magnicons, gyroharmonic converters, free electron masers (FEMs) and of vacuum windows for such high-power mm-wave sources. The highest CW powers produced by

  2. Development of Mode Conversion Waveguides at KIT

    Directory of Open Access Journals (Sweden)

    Jin Jianbo

    2015-01-01

    Full Text Available The development of mode conversion waveguides (launchers for high power gyrotrons has gone through three stages at KIT. Formerly, harmonically deformed launchers have been used in the series gyrotrons developed for the stellarator W7-X. In 2009, a numerical method for the analysis and synthesis of mirror-line launchers was developed at KIT. Such a launcher with adapted mode-converting mirrors for a 2 MW TE34,19-mode, 170GHz coaxial-cavity gyrotron has been designed and tested, and also a mirror-line launcher for the 1MW EU ITER gyrotron has been designed. Recently, based on the Helmholtz-Kirchhoff integral theorem, a novel numerical method for the synthesis of hybrid-type gyrotron launchers has been developed. As an example, TE32,9 mode launchers operating at 170GHz that have been designed using the three different methods are being compared.

  3. Maturing ECRF technology for plasma control

    International Nuclear Information System (INIS)

    The availability of high power, (∼1 MW) long pulse length (effectively cw), high frequency, (>100 GHz) gyrotrons has opened the opportunity for enhanced scientific results on magnetic confinement devices for fusion research worldwide. This has led to successful experiments on electron cyclotron heating, electron cyclotron current drive, non-inductive tokamak operation, tokamak energy transport, suppression of instabilities and advanced profile control leading to enhanced performance. The key development in the gyrotron community that has led to the realization of high power long pulse gyrotrons is the availability of edge cooled synthetic diamond gyrotron output windows, which have low loss and excellent thermal and mechanical properties. In addition to the emergence of reliable high power gyrotrons, ancillary equipment for efficient microwave transmission over distances of hundreds of meters, polarization control, diagnostics, and flexible launch geometry have all been developed and proven in regular service. (author)

  4. ECRH transmission system

    International Nuclear Information System (INIS)

    The M.I.T. gyrotron group operates a 140 GHz, short pulse (1μs) gyrotron with output power, at present, of up to 175 kW. Output radiation has been obtained in several modes, including TE03 at 140 GHz, TE23 at 137 GHz, TE42 at 128 GHz and TE52 at 145 GHz. Studies have been carried out of the mode purity, both in frequency and in space, of gyrotron output radiation. These studies investigate parasitic mode excitation and mode conversion of gyrotron output power. Far field patterns of gyrotron radiation have been investigated to determine mode symmetry and purity. These results are useful in estimating the efficiency of various transmission systems. Finally, a new approach to quasi-optical transmission lines and mode converters, using axisymmetric optics, is suggested

  5. Microwave generation for magnetic fusion energy applications

    International Nuclear Information System (INIS)

    This progress report encompasses work on three separate projects, all related to developing sources for electron cyclotron resonance heating of magnetic fusion plasmas. The report is therefore divided into three parts as follows: free electron lasers with small period wigglers; theory and modeling of high frequency, high power gyrotron operation; and depressed collectors for energy recovery in gyrotrons. Task A is experimental and eventually aims at developing CW sources for ECRH at frequencies as high as 600 GHz. Task B provides gyrotron theory and modeling in support of the gyrotron development programs at MIT and Varian. Task C was phased out in the current contract year but recent publications are included in this report in order to create a permanent record for the use of future researchers with interest in the topic of increasing gyrotron efficiency through the use of depressed collectors

  6. InGaAs Schottky barrier diode array detector for a real-time compact terahertz line scanner.

    Science.gov (United States)

    Han, Sang-Pil; Ko, Hyunsung; Park, Jeong-Woo; Kim, Namje; Yoon, Young-Jong; Shin, Jun-Hwan; Kim, Dae Yong; Lee, Dong Hun; Park, Kyung Hyun

    2013-11-01

    We present a terahertz (THz) broadband antenna-integrated 1 × 20 InGaAs Schottky barrier diode (SBD) array detector with an average responsivity of 98.5 V/W at a frequency of 250 GHz, which is measured without attaching external amplifiers and Si lenses, and an average noise equivalent power (NEP) of 106.6 pW/√Hz. The 3-dB bandwidth of the SBD detector is also investigated at approximately 180 GHz. For implementing an array-type SBD detector by a simple fabrication process to achieve a high yield, a structure comprising an SiN(x) layer instead of an air bridge between the anode and the cathode is designed. THz line beam imaging using a Gunn diode emitter with a center frequency of 250 GHz and a 1 × 20 SBD array detector is successfully demonstrated. PMID:24216813

  7. Dust Emission from High Redshift QSOs

    CERN Document Server

    Carilli, C L; Menten, K M; Rupen, M P; Kreysa, E; Fan, X; Strauss, M A; Schneider, D P; Bertarini, A; Yun, M S; Zylka, R; Fan, Xiaohui; Strauss, Michael A.; Schneider, Donald P.

    2000-01-01

    We present detections of emission at 250 GHz (1.2 mm) from two high redshiftQSOs from the Sloan Digital Sky Survey sample using the bolometer array at theIRAM 30m telescope. The sources are SDSSp 015048.83+004126.2 at z = 3.7, andSDSSp J033829.31+002156.3 at z = 5.0, which is the third highest redshift QSOknown, and the highest redshift mm emitting source yet identified. We alsopresent deep radio continuum imaging of these two sources at 1.4 GHz using theVery Large Array. The combination of cm and mm observations indicate that the250 GHz emission is most likely thermal dust emission, with implied dust massesof 1e8 M_solar. We consider possible dust heating mechanisms, including UVemission from the active nucleus (AGN), and a massive starburst concurrent withthe AGN, with implied star formation rates > 1e3 M_solar/year.

  8. Parametrization, molecular dynamics simulation and calculation of electron spin resonance spectra of a nitroxide spin label on a poly-alanine alpha helix

    OpenAIRE

    Sezer, Deniz; Freed, Jack H.; Roux, Benoît

    2008-01-01

    The nitroxide spin label 1-oxyl-2,2,5,5-tetramethylpyrroline-3-methyl-methanethiosulfonate (MTSSL), commonly used in site-directed spin labeling of proteins, is studied with molecular dynamics (MD) simulations. After developing force field parameters for the nitroxide moiety and the spin label linker, we simulate MTSSL attached to a poly-alanine alpha helix in explicit solvent to elucidate the factors affecting its conformational dynamics. Electron spin resonance spectra at 9 and 250 GHz are ...

  9. Size determination of the Centaur Chariklo from millimeter-wavelength bolometer observations

    OpenAIRE

    Altenhoff, W.J.; Menten, K. M.; Bertoldi, F.

    2000-01-01

    Using the Max-Planck Millimeter Bolometer Array (MAMBO) at the IRAM 30m telescope we detected emission at 250 GHz from the Centaur Chariklo (1997 CU26). The observed continuum flux density implies a photometric diameter of 273 km. The resulting geometric albedo is 0.055, somewhat higher than expected from a comparison with most of the other few Centaurs and cometary nuclei for which such data are available.

  10. The Sensors Connectivity within SCADA Automation Environment and New Trends for Security Development during Multicasting Routing Transmission

    OpenAIRE

    Aamir Shahzad; Kalum Priyanath Udagepola; Young-keun Lee; Soojin Park; Malrey Lee

    2015-01-01

    This study examined the security of SCADA system and its protocols, more specifically, SCADA/DNP3 protocol security. To achieve the study goals, a SCADA simulation environment is designed for water pumping process through connectivity of intelligent sensors, the payload is constructed, and security is deployed inside DNP3 protocol stack and then bytes are multicast to subcontrollers.

  11. Role of p73 Dinucleotide Polymorphism in Prostate Cancer and p73 Protein Isoform Balance

    Directory of Open Access Journals (Sweden)

    L. Michael Carastro

    2014-01-01

    Full Text Available Background. Molecular markers for prostate cancer (PCa risks are currently lacking. Here we address the potential association of a dinucleotide polymorphism (DNP in exon 2 of the p73 gene with PCa risk/progression and discern any disruption of p73 protein isoforms levels in cells harboring a p73 DNP allele. Methods. We investigated the association between p73 DNP genotype and PCa risk/aggressiveness and survival by fitting logistic regression models in 1,292 incident cases and 682 controls. Results. Although we detected no association between p73 DNP and PCa risk, a significant inverse relationship between p73 DNP and PCa aggressiveness (AT/AT + GC/AT versus GC/GC, OR = 0.55, 95%Cl = 0.31–0.99 was detected. Also, p73 DNP is marginally associated with overall death (dominant model, HR = 0.76, 95%Cl = 0.57–1.00, P=0.053 as well as PCa specific death (HR = 0.69, 95%Cl = 0.45–1.06, P=0.09. Western blot analyses for p73 protein isoforms indicate that cells heterozygous for the p73 DNP have lower levels of ∆Np73 relative to TAp73 (P<0.001. Conclusions. Our findings are consistent with an association between p73 DNP and low risk for PCa aggressiveness by increasing the expressed TAp73/∆Np73 protein isoform ratio.

  12. Formulation and utilization of choline based samples for dissolution dynamic nuclear polarization

    DEFF Research Database (Denmark)

    Bowen, Sean; Ardenkjær-Larsen, Jan Henrik

    2013-01-01

    Hyperpolarization by the dissolution dynamic nuclear polarization (DNP) technique permits the generation of high spin polarization of solution state. However, sample formulation for dissolution-DNP is often difficult, as concentration and viscosity must be optimized to yield a dissolved sample...

  13. A 282 GHz Probe for Dynamic Nuclear Polarization

    DEFF Research Database (Denmark)

    Rybalko, Oleksandr; Bowen, Sean; Zhurbenko, Vitaliy;

    Introduction In DNP, microwave irradiation of a sample facilitates the transfer of spin polarization from electrons tonuclei. One of the way to improve the DNP enhancement is to transfer microwave power from the mm-wave source tothe sample more effectively. Several methods and techniques to effic......Introduction In DNP, microwave irradiation of a sample facilitates the transfer of spin polarization from electrons tonuclei. One of the way to improve the DNP enhancement is to transfer microwave power from the mm-wave source tothe sample more effectively. Several methods and techniques...... and power dissipation in free space are negligible. In our construction of the probe we have optimized relevant parameters of the probe. Conclusion We have demonstrated the feasibility of the probe design for DNP applicationsat 10.1 T from the microwave and RF point of view. The performance simulations...

  14. Nano-jewels in biology. Gold and platinum on diamond nanoparticles as antioxidant systems against cellular oxidative stress.

    Science.gov (United States)

    Martín, Roberto; Menchón, Cristina; Apostolova, Nadezda; Victor, Victor M; Alvaro, Mercedes; Herance, José Raúl; García, Hermenegildo

    2010-11-23

    Diamond nanoparticles (DNPs) obtained by explosive detonation have become commercially available. These commercial DNPs can be treated under Fenton conditions (FeSO(4) and H(2)O(2) at acidic pH) to obtain purer DNP samples with a small average particle size (4 nm) and a large population of surface OH groups (HO-DNPs). These Fenton-treated HO-DNPs have been used as a support of gold and platinum nanoparticles (≤2 nm average size). The resulting materials (Au/HO-DNP and Pt/HO-DNP) exhibit a high antioxidant activity against reactive oxygen species induced in a hepatoma cell line. In addition to presenting good biocompatibility, Au/HO- and Pt/HO-DNP exhibit about a two-fold higher antioxidant activity than glutathione, one of the reference antioxidant systems. The most active material against cellular oxidative stress was Au/HO-DNP. PMID:20939514

  15. Fenton-treated functionalized diamond nanoparticles as gene delivery system.

    Science.gov (United States)

    Martín, Roberto; Alvaro, Mercedes; Herance, José Raúl; García, Hermenegildo

    2010-01-26

    When raw diamond nanoparticles (Dnp, 7 nm average particle size) obtained from detonation are submitted to harsh Fenton-treatment, the resulting material becomes free of amorphous soot matter and the process maintains the crystallinity, reduces the particle size (4 nm average particle size), increases the surface OH population, and increases water solubility. All these changes are beneficial for subsequent Dnp covalent functionalization and for the ability of Dnp to cross cell membranes. Fenton-treated Dnps have been functionalized with thionine and the resulting sample has been observed in HeLa cell nuclei. A triethylammonium-functionalized Dnp pairs electrostatically with a plasmid having the green fluorescent protein gene and acts as gene delivery system permitting the plasmid to cross HeLa cell membrane, something that does not occur for the plasmid alone without assistance of polycationic Dnp. PMID:20047335

  16. The magnetic field dependence of cross-effect dynamic nuclear polarization under magic angle spinning

    International Nuclear Information System (INIS)

    We develop a theoretical description of Dynamic Nuclear Polarization (DNP) in solids under Magic Angle Spinning (MAS) to describe the magnetic field dependence of the DNP effect. The treatment is based on an efficient scheme for numerical solution of the Liouville-von Neumann equation, which explicitly takes into account the variation of magnetic interactions during the sample spinning. The dependence of the cross-effect MAS-DNP on various parameters, such as the hyperfine interaction, electron-electron dipolar interaction, microwave field strength, and electron spin relaxation rates, is analyzed. Electron spin relaxation rates are determined by electron paramagnetic resonance measurements, and calculations are compared to experimental data. Our results suggest that the observed nuclear magnetic resonance signal enhancements provided by MAS-DNP can be explained by discriminating between “bulk” and “core” nuclei and by taking into account the slow DNP build-up rate for the bulk nuclei

  17. Design and operation of the power installation for the TCV ECR additional heating

    Energy Technology Data Exchange (ETDEWEB)

    Fasel, D.; Favre, A.; Goodman, T.; Henderson, M.; Isoz, P.F.; Perez, A.; Tran, M.Q. [Ecole Polytechnique Federale, Lausanne (Switzerland). Centre de Recherche en Physique des Plasma (CRPP); Alex, J. [Thomcast AG, Turgi (Switzerland)

    1996-10-01

    Following a brief introduction to the TCV project, this paper concentrates on the Regulated High Voltage Power Supply (RHVPS) system chosen to supply the nine gyrotrons, distributed in three clusters, that will deliver 4.5 MW of Electron Cyclotron Resonance Heating (ECRH) to TCV plasmas. The configuration of these clusters is described in some detail, including the results of site test both with dummy load (80 kV, 85 A, 2 sec) and the gyrotrons themselves (70 kV, 25 A, 2 sec). Some details are also given of gyrotron auxiliaries, interlock circuitry, control and data acquisition, and integration into TCV control environment. (author) 4 figs., 1 tab., 4 refs.

  18. Proteomic analysis on N, N′-dinitrosopiperazine-mediated metastasis of nasopharyngeal carcinoma 6-10B cells

    Directory of Open Access Journals (Sweden)

    Li Yuejin

    2012-11-01

    Full Text Available Abstract Background Nasopharyngeal carcinoma (NPC has a high metastatic feature. N,N′-Dinitrosopiperazine (DNP is involved in NPC metastasis, but its mechanism is not clear. The aim of this study is to reveal the pathogenesis of DNP-involved metastasis. 6-10B cells with low metastasis are from NPC cell line SUNE-1, were used to investigate the mechanism of DNP-mediated NPC metastasis. Results 6-10B cells were grown in DMEM containing 2H4-L-lysine and 13C 6 15 N4-L-arginine or conventional L-lysine and L-arginine, and identified the incorporation of amino acid by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Labeled 6-10B cells were treated with DNP at 0 -18 μM to establish the non-cytotoxic concentration (NCC range. NCC was 0 -10 μM. Following treatment with DNP at this range, the motility and invasion of cells were detected in vitro, and DNP-mediated metastasis was confirmed in the nude mice. DNP increased 6-10B cell metastasis in vitro and vivo. DNP-induced protein expression was investigated using a quantitative proteomic. The SILAC-based approach quantified 2698 proteins, 371 of which showed significant change after DNP treatment (172 up-regulated and 199 down-regulated proteins. DNP induced the change in abundance of mitochondrial proteins, mediated the status of oxidative stress and the imbalance of redox state, increased cytoskeletal protein, cathepsin, anterior gradient-2, and clusterin expression. DNP also increased the expression of secretory AKR1B10, cathepsin B and clusterin 6-10B cells. Gene Ontology and Ingenuity Pathway analysis showed that DNP may regulate protein synthesis, cellular movement, lipid metabolism, molecular transport, cellular growth and proliferation signaling pathways. Conclusion DNP may regulate cytoskeletal protein, cathepsin, anterior gradient-2, and clusterin expression, increase NPC cells motility and invasion, is involved NPC metastasis.

  19. Low-Temperature Dynamic Nuclear Polarization at 9.4 Tesla With a 30 Milliwatt Microwave Source

    Science.gov (United States)

    Thurber, Kent R.; Yau, Wai-Ming; Tycko, Robert

    2010-01-01

    Dynamic nuclear polarization (DNP) can provide large signal enhancements in nuclear magnetic resonance (NMR) by transfer of polarization from electron spins to nuclear spins. We discuss several aspects of DNP experiments at 9.4 Tesla (400 MHz resonant frequency for 1H, 264 GHz for electron spins in organic radicals) in the 7–80 K temperature range, using a 30 mW, frequency-tunable microwave source and a quasi-optical microwave bridge for polarization control and low-loss microwave transmission. In experiments on frozen glycerol/water doped with nitroxide radicals, DNP signal enhancements up to a factor of 80 are observed (relative to 1H NMR signals with thermal equilibrium spin polarization). The largest sensitivity enhancements are observed with a new triradical dopant, DOTOPA-TEMPO. Field modulation with a 10 G root-mean-squared amplitude during DNP increases the nuclear spin polarizations by up to 135%. Dependencies of 1H NMR signal amplitudes, nuclear spin relaxation times, and DNP build-up times on the dopant and its concentration, temperature, microwave power, and modulation frequency are reported and discussed. The benefits of low-temperature DNP can be dramatic: the 1H spin polarization is increased approximately 1000-fold at 7 K with DNP, relative to thermal polarization at 80 K. PMID:20392658

  20. EC-5 fifth international workshop on electron cyclotron emission and electron cyclotron heating

    Energy Technology Data Exchange (ETDEWEB)

    Prater, R.; Lohr, J. [eds.

    1985-12-31

    This report contains papers on the following topics: electron cyclotron emission measurements; electron cyclotron emission theory; electron cyclotron heating; gyrotron development; and ECH systems and waveguide development. These paper have been indexed separately elsewhere. (LSP).

  1. Combined administration of cerebrolysin and donepezil induces plastic changes in prefrontal cortex in aged mice.

    Science.gov (United States)

    Alcántara-González, Faviola; Mendoza-Perez, Claudia Rebeca; Zaragoza, Néstor; Juarez, Ismael; Arroyo-García, Luis Enrique; Gamboa, Citlalli; De La Cruz, Fidel; Zamudio, Sergio; Garcia-Dolores, Fernando; Flores, Gonzalo

    2012-11-01

    Cerebrolysin (Cbl) shows neurotrophic and neuroprotective properties while donepezil (Dnp) is a potent acetylcholinesterase (AChE) inhibitor, both drugs are prescribed for Alzheimer's disease (AD) treatment. Previous studies have shown that the Dnp and Cbl administered separately, modify dendritic morphology of neurons in the prefrontal cortex and hippocampus in senile rodents. Since the deficit of neurotrophic factor activity is implicated in the degeneration of cholinergic neurons of basal forebrain, a combination therapy of Dnp and Cbl has been tested recently in Alzheimer's patients. However, the plastic changes that may underlie this combined treatment have not yet been explored. We present here the effect of the combined administration of Cbl and Dnp on dendritic morphology in brain regions related to learning and memory in aged mice. The Golgi-Cox staining protocol and Sholl analysis were used for studying dendritic changes. Cbl and Dnp were administrated daily for 2 months to 9-months-old mice. Locomotor activity was assessed, as well as the dendritic morphology of neurons in several limbic regions was analyzed. Results showed that Cbl and Dnp induced an increase in locomotor activity without synergistic effect. The Cbl or Dnp treatment modified the dendritic morphology of neurons from prefrontal cortex (PFC), dorsal hippocampus (DH), dentate gyrus (DG), and the shell of nucleus accumbens (NAcc). These changes show an increase in the total dendritic length and spine density, resulting in an improvement of dendritic arborization. Prominently, a synergistic effect of Cbl and Dnp was observed on branching order and total dendritic length of pyramidal neurons from PFC. These results suggest that Dnp and Cbl may induce plastic changes in a manner independent of each other, but could enhance their effect in target cells from PFC. PMID:22826038

  2. Combined administration of cerebrolysin and donepezil induces plastic changes in prefrontal cortex in aged mice.

    Science.gov (United States)

    Alcántara-González, Faviola; Mendoza-Perez, Claudia Rebeca; Zaragoza, Néstor; Juarez, Ismael; Arroyo-García, Luis Enrique; Gamboa, Citlalli; De La Cruz, Fidel; Zamudio, Sergio; Garcia-Dolores, Fernando; Flores, Gonzalo

    2012-11-01

    Cerebrolysin (Cbl) shows neurotrophic and neuroprotective properties while donepezil (Dnp) is a potent acetylcholinesterase (AChE) inhibitor, both drugs are prescribed for Alzheimer's disease (AD) treatment. Previous studies have shown that the Dnp and Cbl administered separately, modify dendritic morphology of neurons in the prefrontal cortex and hippocampus in senile rodents. Since the deficit of neurotrophic factor activity is implicated in the degeneration of cholinergic neurons of basal forebrain, a combination therapy of Dnp and Cbl has been tested recently in Alzheimer's patients. However, the plastic changes that may underlie this combined treatment have not yet been explored. We present here the effect of the combined administration of Cbl and Dnp on dendritic morphology in brain regions related to learning and memory in aged mice. The Golgi-Cox staining protocol and Sholl analysis were used for studying dendritic changes. Cbl and Dnp were administrated daily for 2 months to 9-months-old mice. Locomotor activity was assessed, as well as the dendritic morphology of neurons in several limbic regions was analyzed. Results showed that Cbl and Dnp induced an increase in locomotor activity without synergistic effect. The Cbl or Dnp treatment modified the dendritic morphology of neurons from prefrontal cortex (PFC), dorsal hippocampus (DH), dentate gyrus (DG), and the shell of nucleus accumbens (NAcc). These changes show an increase in the total dendritic length and spine density, resulting in an improvement of dendritic arborization. Prominently, a synergistic effect of Cbl and Dnp was observed on branching order and total dendritic length of pyramidal neurons from PFC. These results suggest that Dnp and Cbl may induce plastic changes in a manner independent of each other, but could enhance their effect in target cells from PFC.

  3. Dispersion of helically corrugated waveguides: Analytical, numerical, and experimental study

    Science.gov (United States)

    Burt, G.; Samsonov, S. V.; Ronald, K.; Denisov, G. G.; Young, A. R.; Bratman, V. L.; Phelps, A. D.; Cross, A. W.; Konoplev, I. V.; He, W.; Thomson, J.; Whyte, C. G.

    2004-10-01

    Helically corrugated waveguides have recently been studied for use in various applications such as interaction regions in gyrotron traveling-wave tubes and gyrotron backward-wave oscillators and as a dispersive medium for passive microwave pulse compression. The paper presents a summary of various methods that can be used for analysis of the wave dispersion of such waveguides. The results obtained from an analytical approach, simulations with the three-dimensional numerical code MAGIC, and cold microwave measurements are analyzed and compared.

  4. 300GHz 材料プロセッシング装置の開発

    OpenAIRE

    光藤, 誠太郎; 坂井, 和喜; 小林, 一生; 中野, 智彰; 出原, 敏孝; 斉藤, 輝雄

    2007-01-01

    High power THz-frequency material processing has great potential for the applications. The gyrotron is a microwave tube capable of delivering very high microwave power in the pulse and CW operation at the THz frequencies. The frequency of gyrotron is proportional to the intensity of magnetic field, because the operation results from the mechanism of “cyclotron resonance maser”. Therefore, in order to achieve high frequency operation, we need a high magnetic field which superconducting magne...

  5. Characterization of high-power RF structures using time-domain field codes

    International Nuclear Information System (INIS)

    We have modeled gyrotron windows and gyrotron amplifier sever structures for TE modes in the 100-150 GHz range and have computed the reflection and transmission characteristics from the field data. Good agreement with frequency domain codes and analytic analysis have been obtained for some simple geometries. We present results for realistic structures with lossy coatings and describe implementation of microwave diagnostics. (Author) 5 figs., 7 refs

  6. Prospects for Sub-Micron Solid State Nuclear Magnetic Resonance Imaging with Low-Temperature Dynamic Nuclear Polarization

    OpenAIRE

    Thurber, Kent R.; Tycko, Robert

    2010-01-01

    We evaluate the feasibility of 1H nuclear magnetic resonance (NMR) imaging with sub-micron voxel dimensions using a combination of low temperatures and dynamic nuclear polarization (DNP). Experiments are performed on nitroxide-doped glycerol/water at 9.4 T and temperatures below 40 K, using a 30 mW tunable microwave source for DNP. With DNP at 7 K, a 0.5 µl sample yields a 1H NMR signal-to-noise ratio of 770 in two scans with pulsed spin-lock detection and after 80 db signal attenuation. With...

  7. The ethics curriculum for doctor of nursing practice programs.

    Science.gov (United States)

    Peirce, Anne Griswold; Smith, Jennifer A

    2008-01-01

    Ethical questions dealt with by nurses who have Doctor of Nursing Practice (DNP) degrees include traditional bioethical questions, but also business and legal ethics. Doctorally prepared nurses are increasingly in positions to make ethical decisions rather than to respond to decisions made by others. The traditional master's-degree advanced practice nursing curriculum does not address the extended expertise and decision-making skills needed by DNP practitioners as they face these new types of ethical dilemmas. We propose that a curricular framework that addresses clinical, research, business, and legal ethics is needed by all DNP students.

  8. Progress of microwave collective Thomson scattering in LHD

    International Nuclear Information System (INIS)

    Microwave collective Thomson scattering (CTS) by using a 77 GHz gyrotron is routinely working in LHD and the improvements of the system is now underway. The targets of this diagnostic are measurements of energetic fast ion distribution and ion ratio. In the present system, 800kW 77 GHz gyrotron is injected horizontally and scattered radiation is received changing scattering angle. The system works with existence of electron cyclotron resonance layer. Thus, most of the power is absorbed at the layer like beam damping and stray radiation dramatically decreases. Gyrotron is modulated at 40 Hz, then, background ECE, which is signal in gyrotron off phase, is subtracted from scattered signal in gyrotron on phase. The perturbation of electron temperature due to the gyrotron injection is almost negligible. Temporal evolution of CTS spectrum is obtained by 32ch filter bank receiver through discharge and fine spectrum is obtained by 10 GHz sampling fast digitizer for 80 ms. Change of the width and asymmetry of CTS spectrum is observed after turning off of tangentially injected neutral beam (NB). This is qualitatively consistent with reduction of fast ion density. Preliminary data of ion ratio between hydrogen and helium are also obtained

  9. ECH Technology Development

    Energy Technology Data Exchange (ETDEWEB)

    Temkin, Richard [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

    2014-12-24

    Electron Cyclotron Heating (ECH) is needed for plasma heating, current drive, plasma stability control, and other applications in fusion energy sciences research. The program of fusion energy sciences supported by U. S. DOE, Office of Science, Fusion Energy Sciences relies on the development of ECH technology to meet the needs of several plasma devices working at the frontier of fusion energy sciences research. The largest operating ECH system in the world is at DIII-D, consisting of six 1 MW, 110 GHz gyrotrons capable of ten second pulsed operation, plus two newer gyrotrons. The ECH Technology Development research program investigated the options for upgrading the DIII-D 110 GHz ECH system. Options included extending present-day 1 MW technology to 1.3 – 1.5 MW power levels or developing an entirely new approach to achieve up to 2 MW of power per gyrotron. The research consisted of theoretical research and designs conducted by Communication and Power Industries of Palo Alto, CA working with MIT. Results of the study would be validated in a later phase by research on short pulse length gyrotrons at MIT and long pulse / cw gyrotrons in industry. This research follows a highly successful program of development that has led to the highly reliable, six megawatt ECH system at the DIII-D tokamak. Eventually, gyrotrons at the 1.5 megawatt to multi-megawatt power level will be needed for heating and current drive in large scale plasmas including ITER and DEMO.

  10. Microwave generation for magnetic fusion energy applications, Task B

    International Nuclear Information System (INIS)

    One of the main issues in the development of high power gyrotrons is the present discrepancy between the theoretically predicted efficiency and that observed in the experiments. Recent 140 GHz experiments by MIT employed three cavities; two of the cavities have different interaction lengths and the third cavity is a complex two-section cavity. In all cases, the maximum experimental efficiency is well below the theoretically predicted one. A better theoretical understanding of the causes of these discrepancies is essential to the scaling of gyrotrons to higher power and higher frequency. We continued our investigation with the objective of determining whether mode competition and velocity spread in the electron beam could in some way be influencing the current result from the MIT 140 GHz gyrotrons experiments and determining to what extent these effects would influence operation of a 1 MW, 280 GHz, TE42,7 gyrotron as conceived at MIT. In our investigations, we used two models, the ''fixed axial field profile'' model and the ''self-consistent determination of the axial field profile'' model. With the ''fixed axial field profile'' model we studied the effect of thermal spread on the efficiency of gyrotrons operation, mode competition between unequally spaced modes, and we simulated the start up of the MIT 140 GHz gyrotrons. Our main conclusions from all these studies are discussed in this paper

  11. Surface Binding of TOTAPOL Assists Structural Investigations of Amyloid Fibrils by Dynamic Nuclear Polarization NMR Spectroscopy.

    Science.gov (United States)

    Nagaraj, Madhu; Franks, Trent W; Saeidpour, Siavash; Schubeis, Tobias; Oschkinat, Hartmut; Ritter, Christiane; van Rossum, Barth-Jan

    2016-07-15

    Dynamic nuclear polarization (DNP) NMR can enhance sensitivity but often comes at the price of a substantial loss of resolution. Two major factors affect spectral quality: low-temperature heterogeneous line broadening and paramagnetic relaxation enhancement (PRE) effects. Investigations by NMR spectroscopy, isothermal titration calorimetry (ITC), and EPR revealed a new substantial affinity of TOTAPOL to amyloid surfaces, very similar to that shown by the fluorescent dye thioflavin-T (ThT). As a consequence, DNP spectra with remarkably good resolution and still reasonable enhancement could be obtained at very low TOTAPOL concentrations, typically 400 times lower than commonly employed. These spectra yielded several long-range constraints that were difficult to obtain without DNP. Our findings open up new strategies for structural studies with DNP NMR spectroscopy on amyloids that can bind the biradical with affinity similar to that shown towards ThT. PMID:27147408

  12. Dynamic nuclear polarization for magnetic resonance imaging. An in-bore approach

    Energy Technology Data Exchange (ETDEWEB)

    Krummenacker, Jan G.

    2012-07-01

    In this thesis, the development of an in-bore liquid state DNP polarizer for MRI applications operating in flow through mode at a magnetic field strength of 1.5 T was described. After an introductory chapter 1 and a chapter 2 on the theoretical background, chapter 3 dealt chiefly with the challenge of performing liquid state DNP at a high magnetic field of 9.2 T. The feasibility of performing liquid state DNP at this field was demonstrated for various solvents, as well as for metabolites in solution. Chapter 4 then moved to the aim of this work, the application of liquid state DNP for MRI experiments. It introduced the rationale of our approach, the hardware that was developed and demonstrated its performance in a clinical MRI tomograph.

  13. Dynamic nuclear polarization for magnetic resonance imaging. An in-bore approach

    International Nuclear Information System (INIS)

    In this thesis, the development of an in-bore liquid state DNP polarizer for MRI applications operating in flow through mode at a magnetic field strength of 1.5 T was described. After an introductory chapter 1 and a chapter 2 on the theoretical background, chapter 3 dealt chiefly with the challenge of performing liquid state DNP at a high magnetic field of 9.2 T. The feasibility of performing liquid state DNP at this field was demonstrated for various solvents, as well as for metabolites in solution. Chapter 4 then moved to the aim of this work, the application of liquid state DNP for MRI experiments. It introduced the rationale of our approach, the hardware that was developed and demonstrated its performance in a clinical MRI tomograph.

  14. Enhanced antibody affinity in sublethally irradiated mice and bone marrow chimeras

    International Nuclear Information System (INIS)

    Sublethally irradiated mice primed with dinitrophenyl (Dnp)-keyhole limpet hemocyanin immediately after irradiation or 30 days later and subsequently boosted with a second injection of antigen displayed a secondary response to Dnp characterized by antibody affinity greater than that in unirradiated controls. Also, in radiation chimeras primed with Dnp-keyhole limpet hemocyanin 120 days after syngeneic or allogeneic bone marrow transplantation the antibodies against Dnp produced after boosting were of higher affinity than the antibodies raised in normal mice. These findings are tentatively attributed to lack of suppressor thymus-derived lymphocytes (T cells) in sublethally irradiated mice and bone marrow chimeras, in which the enhanced ability to produce antibodies of high affinity may compensate for quantitative defects of the immune system

  15. Dissolution Dynamic Nuclear Polarization of Non-Self-Glassing Agents: Spectroscopy and Relaxation of Hyperpolarized [1-13C]Acetate

    DEFF Research Database (Denmark)

    Flori, Alessandra; Liserani, Matteo; Bowen, Sean;

    2015-01-01

    The intrinsic physicochemical properties of the sample formulation are the key factors for efficient hyperpolarization through dissolution dynamic nuclear polarization (dissolution-DNP). We provide a comprehensive characterization of the DNP process for Na-[1-13C]acetate selected as a model for n....... The results reported here describe the constraints of the acetate formulation useful for future studies in this field with non-self-glassing enriched molecules.......The intrinsic physicochemical properties of the sample formulation are the key factors for efficient hyperpolarization through dissolution dynamic nuclear polarization (dissolution-DNP). We provide a comprehensive characterization of the DNP process for Na-[1-13C]acetate selected as a model for non-self...

  16. 1H and 15N Dynamic Nuclear Polarization Studies of Carbazole

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Jian Zhi; Solum, Mark S.; Wind, Robert A.; Nilsson, Brad L.; Peterson, Matt A.; Pugmire, Ronald J.; Grant, David M.

    2000-01-01

    15N NMR experiments, combined with dynamic nuclear polarization (DNP), are reported on carbazole doped with the stable free radical 1,3 bisdiphenylene-2 phenylally1 (BDPA). Doping shortens the nuclear relaxation times and provides paramagnetic centers that can be used to enhance the nuclear signal by means of DNP so that 15 N NMR experiments can be done in minutes. The factors were measured in a 1.4 T external field, using both unlabeled and 98% 15N labeled carbazole with doping levels varying between 0.65 and 5.0 wt % BDPA. A doping level of approximately 1 wt % produced optimal results. DNP enhancement factors of 35 and 930 were obtained for 1H and 15N, respectively making it possible to perform 15N DNP NMR experiments at the natural abundance level.

  17. 78 FR 37234 - Notice of Invitation; Coal Exploration License Application NDM 105349, ND

    Science.gov (United States)

    2013-06-20

    ... Office, 5001 Southgate Drive, Billings, Montana. A written notice to participate in the exploration license should be sent to the State Director, BLM Montana State Office, 5001 Southgate Drive, Billings, MT.... BILLING CODE 4310-DN-P...

  18. Resonance-inclined optical nuclear spin polarization of liquids in diamond structures

    CERN Document Server

    Chen, Qiong; Jelezko, Fedor; Retzker, Alex; Plenio, Martin B

    2015-01-01

    Dynamic nuclear polarization (DNP) of molecules in a solution at room temperature has potential to revolutionize nuclear magnetic resonance spectroscopy and imaging. The prevalent methods for achieving DNP in solutions are typically most effective in the regime of small interaction correlation times between the electron and nuclear spins, limiting the size of accessible molecules. To solve this limitation, we design a mechanism for DNP in the liquid phase that is applicable for large interaction correlation times. Importantly, while this mechanism makes use of a resonance condition similar to solid-state DNP, the polarization transfer is robust to a relatively large detuning from the resonance due to molecular motion. We combine this scheme with optically polarized nitrogen vacancy (NV) center spins in nanodiamonds to design a setup that employs optical pumping and is therefore not limited by room temperature electron thermal polarisation. We illustrate numerically the effectiveness of the model in a flow cel...

  19. The use of dynamic nuclear polarization in 1H and 13C solid state NMR

    International Nuclear Information System (INIS)

    The Dynamic Nuclear Polarization (DNP) effect is used at room temperature in combination with 13C NMR. Due to the low natural abundance of 13C spins (1%) the signal is very weak, but when the DNP effect is used the 13C signal can be enhanced and therefore the number of scans and the measuring time considerably reduced. The theory is presented and the experimental set-up is described. Experiments on polystyrene, artificially doped with free radicals are described and it is examined whether the theory of the DNP effect can be used in a quantitative way. Applications of the use of the DNP effect in 13C NMR are shown. Excellent spectra are presented of artificial and natural diamonds, possibly to be used for diamond characterization purposes. 161 refs.; 61 figs.; 3 tabs

  20. The ECRH system for JET-EP

    International Nuclear Information System (INIS)

    An ECW (electron cyclotron wave) system is being designed for JET. The system will consist of 6 gyrotrons, 1 MW each, in order to deliver 5 MW into the plasma. An extension of 2 more gyrotrons is recently being considered. The system will especially be designed to enable the control of neo-classical tearing modes (NTM). Furthermore, heating and current drive is foreseen in a large number of different target plasma configurations and the control of the ratio of the electron and ion temperatures. The frequency, 113.3 GHz, is selected to enable a wide range of operating toroidal magnetic fields from 3 to 4 T and at second harmonic at lower fields and also to allow for a future upgrade to 170 GHz using the same systems, including the double-disk diamond windows. The main elements of the ECW system are: gyrotrons with a depressed collector, 1 MW each, 10 s pulse duration with a diamond window, with Gaussian output mode; main power supplies, up to 60 kV, with a solid-state crowbar to feed two gyrotrons. A series IGBT switch will enable independent control of each gyrotron; evacuated waveguides or quasi-optical mirror lines will be each capable of transmitting 1 MW, having a double-disk diamond window located near the torus as an additional tritium barrier. The total length is in the order of 80 to 100m; a plug-in launcher, steerable in both toroidal and poloidal angle. A trade-off will be made between a single launching mirror per transmission line or two beams per launching mirror in order to have the highest flexibility, but also the narrowest beam size in the plasma. The gyrotron power supplies. The configuration of the collector power supply is based on the connection of two gyrotrons to one existing (former lower hybrid) 60 kV power supply. To limit the energy deposit into an internal arc, IGBT switches are connected in series with the gyrotrons, to disconnect the gyrotron from the power supply within 2 μs. An LR snubber is connected in series with the gyrotrons to

  1. Electron paramagnetic resonance and dynamic nuclear polarization of char suspensions: surface science and oximetry

    DEFF Research Database (Denmark)

    Clarkson, R B; Odintsov, B M; Ceroke, P J;

    1998-01-01

    Carbon chars have been synthesized in our laboratory from a variety of starting materials, by means of a highly controlled pyrolysis technique. These chars exhibit electron paramagnetic resonance (EPR) line shapes which change with the local oxygen concentration in a reproducible and stable fashion...... in conjunction with electron Zeeman pumping. Low-frequency EPR, DNP and DNP-enhanced MRI all show promise as oximetry methods when used with carbon chars....

  2. Hyperpolarized 13C metabolic imaging using dissolution dynamic nuclear polarization

    DEFF Research Database (Denmark)

    Hurd, Ralph E.; Yen, Yi‐Fen; Chen, Albert;

    2012-01-01

    This article describes the basic physics of dissolution dynamic nuclear polarization (dissolution‐DNP), and the impact of the resulting highly nonequilibrium spin states, on the physics of magnetic resonance imaging (MRI) detection. The hardware requirements for clinical translation of this techn......This article describes the basic physics of dissolution dynamic nuclear polarization (dissolution‐DNP), and the impact of the resulting highly nonequilibrium spin states, on the physics of magnetic resonance imaging (MRI) detection. The hardware requirements for clinical translation...

  3. Solid effect dynamic nuclear polarization and polarization pathways

    OpenAIRE

    Smith, Albert A.; Corzilius, Björn; Barnes, Alexander B.; Maly, Thorsten; Griffin, Robert G.

    2012-01-01

    Using dynamic nuclear polarization (DNP)/nuclear magnetic resonance instrumentation that utilizes a microwave cavity and a balanced rf circuit, we observe a solid effect DNP enhancement of 94 at 5 T and 80 K using trityl radical as the polarizing agent. Because the buildup rate of the solid effect increases with microwave field strength, we obtain a sensitivity gain of 128. The data suggest that higher microwave field strengths would lead to further improvements in sensitivity. In addition, t...

  4. Broadband millimeter-wave GaAs transmitters and receivers using planar bow-tie antennas

    Science.gov (United States)

    Konishi, Y.; Kamegawa, M.; Case, M.; Yu, R.; Rodwell, M. J. W.; York, R. A.; Rutledge, D. B.

    1992-01-01

    We report broadband monolithic transmitters and receivers IC's for mm-wave electromagnetic measurements. The IC's use nonlinear transmission lines (NLTL) and sampling circuits as picosecond pulse generators and detectors. The pulses are radiated and received by planar monolithic bow-tie antennas, collimated with silicon substrate lenses and off-axis parabolic reflectors. Through Fourier transformation of the received pulse, 30-250 GHz free space gain-frequency measurements are demonstrated with an accuracy approximately = 0.17 dB, RMS.

  5. Photoassociative production of ultracold heteronuclear YbLi* molecules

    CERN Document Server

    Roy, Richard; Green, Alaina; Gupta, Subhadeep; Li, Ming; Kotochigova, Svetlana; Petrov, Alexander; Yuen, Chi Hong

    2016-01-01

    We report on the production of ultracold heteronuclear YbLi* molecules in a dual-species magneto-optical trap by photoassociation (PA). The formation of the electronically excited molecules close to dissociation was observed by trap loss spectroscopy. We find 4 rovibrational states within a range of $250\\,$GHz below the Yb($^1S_0$) + Li($^2P_{1/2}$) asymptote and observe isotopic PA line shifts in mixtures of $^6$Li with $^{174}$Yb, $^{172}$Yb, and $^{176}$Yb. We also describe our theoretical ab-initio calculation for the relevant electronic potentials and utilize it to analyze and identify the lines in the experimentally observed spectrum.

  6. HIV-Associated Distal Neuropathic Pain is Associated with Smaller Total Cerebral Cortical Gray Matter

    Science.gov (United States)

    Keltner, John R.; Fennema-Notestine, Christine; Vaida, Florin; Wang, Dongzhe; Franklin, Donald R.; Dworkin, Robert H.; Sanders, Chelsea; McCutchan, J. Allen; Archibald, Sarah L.; Miller, David J.; Kesidis, George; Cushman, Clint; Kim, Sung Min; Abramson, Ian; Taylor, Michael J.; Theilmann, Rebecca J.; Julaton, Michelle D.; Notestine, Randy J.; Corkran, Stephanie; Cherner, Mariana; Duarte, Nichole A.; Alexander, Terry; Robinson-Papp, Jessica; Gelman, Benjamin B.; Simpson, David M.; Collier, Ann C.; Marra, Christina M.; Morgello, Susan; Brown, Greg; Grant, Igor; Atkinson, J. Hampton; Jernigan, Terry L.; Ellis, Ronald J.

    2014-01-01

    Despite modern antiretroviral therapy, HIV-associated sensory neuropathy affects over 50% of HIV patients. The clinical expression of HIV neuropathy is highly variable: many individuals report few symptoms, but about half report distal neuropathic pain (DNP), making it one of the most prevalent, disabling and treatment-resistant complications of HIV disease. The presence and intensity of pain is not fully explained by the degree of peripheral nerve damage, making it unclear why some patients do, and others do not, report pain. To better understand central nervous system contributions to HIV DNP, we performed a cross-sectional analysis of structural magnetic resonance imaging (MRI) volumes in 241 HIV-infected participants from an observational multi-site cohort study at five US sites (CNS HIV Antiretroviral Treatment Effects Research Study, CHARTER). The association between DNP and the structural imaging outcomes was investigated using both linear and nonlinear (Gaussian Kernel support vector) multivariable regression, controlling for key demographic and clinical variables. Severity of DNP symptoms was correlated with smaller total cerebral cortical gray matter volume (R = −0.24; p = 0.004). Understanding the mechanisms for this association between smaller total cortical volumes and DNP may provide insight into HIV DNP chronicity and treatment-resistance. PMID:24549970

  7. Dynamic nuclear polarization-magnetic resonance imaging at low ESR irradiation frequency for ascorbyl free radicals

    Science.gov (United States)

    Ito, Shinji; Hyodo, Fuminori

    2016-02-01

    Highly water-soluble ubiquinone-0 (CoQ0) reacts with ascorbate monoanion (Asc) to mediate the production of ascorbyl free radicals (AFR). Using aqueous reaction mixture of CoQ0 and Asc, we obtained positively enhanced dynamic nuclear polarization (DNP)-magnetic resonance (MR) images of the AFR at low frequency (ranging from 515 to 530 MHz) of electron spin resonance (ESR) irradiation. The shape of the determined DNP spectrum was similar to ESR absorption spectra with doublet spectral peaks. The relative locational relationship of spectral peaks in the DNP spectra between the AFR (520 and 525 MHz), 14N-labeled carbamoyl-PROXYL (14N-CmP) (526.5 MHz), and Oxo63 (522 MHz) was different from that in the X-band ESR spectra, but were similar to that in the 300-MHz ESR spectra. The ratio of DNP enhancement to radical concentration for the AFR was higher than those for 14N-CmP, Oxo63, and flavin semiquinone radicals. The spectroscopic DNP properties observed for the AFR were essentially the same as those for AFR mediated by pyrroloquinoline quinone. Moreover, we made a success of in vivo DNP-MR imaging of the CoQ0-mediated AFR which was administered by the subcutaneous and oral injections as an imaging probe.

  8. Dynamic nuclear polarization of nucleic acid with endogenously bound manganese

    Energy Technology Data Exchange (ETDEWEB)

    Wenk, Patricia [University of Tübingen, Werner Siemens Imaging Center and Department of Preclinical Imaging and Radiopharmacy (Germany); Kaushik, Monu; Richter, Diane [Goethe University, Institute of Physical und Theoretical Chemistry, Institute of Biophysical Chemistry und Center for Biomolecular Magnetic Resonance (BMRZ) (Germany); Vogel, Marc; Suess, Beatrix [Technical University Darmstadt, Department of Biology (Germany); Corzilius, Björn, E-mail: corzilius@em.uni-frankfurt.de [Goethe University, Institute of Physical und Theoretical Chemistry, Institute of Biophysical Chemistry und Center for Biomolecular Magnetic Resonance (BMRZ) (Germany)

    2015-09-15

    We report the direct dynamic nuclear polarization (DNP) of {sup 13}C nuclei of a uniformly [{sup 13}C,{sup 15}N]-labeled, paramagnetic full-length hammerhead ribozyme (HHRz) complex with Mn{sup 2+} where the enhanced polarization is fully provided by the endogenously bound metal ion and no exogenous polarizing agent is added. A {sup 13}C enhancement factor of ε = 8 was observed by intra-complex DNP at 9.4 T. In contrast, “conventional” indirect and direct DNP experiments were performed using AMUPol as polarizing agent where we obtained a {sup 1}H enhancement factor of ε ≈ 250. Comparison with the diamagnetic (Mg{sup 2+}) HHRz complex shows that the presence of Mn{sup 2+} only marginally influences the (DNP-enhanced) NMR properties of the RNA. Furthermore two-dimensional correlation spectra ({sup 15}N–{sup 13}C and {sup 13}C–{sup 13}C) reveal structural inhomogeneity in the frozen, amorphous state indicating the coexistence of several conformational states. These demonstrations of intra-complex DNP using an endogenous metal ion as well as DNP-enhanced MAS NMR of RNA in general yield important information for the development of new methods in structural biology.

  9. Determination of electromagnetic modes in oversized corrugated waveguides on the electron cyclotron resonance heating installation at the tokamak Tore Supra; Determination de modes electromagnetiques de guides d'ondes corrugues surdimensionnes sur l'installation de chauffage des electrons de tokamak Tore Supra

    Energy Technology Data Exchange (ETDEWEB)

    Courtois, L

    2001-03-09

    Electron cyclotron resonance heating (ECRH) in the Tore Supra tokamak constitutes an important step in the research aimed at obtaining thermonuclear fusion reactions. Electron heating is achieved by transmitting an electromagnetic wave from the oscillators (gyrotrons) to the plasma via the fundamental mode, propagating in oversized corrugated waveguides. Maximizing the proportion of the gyrotron power coupled to the fundamental waveguide mode is essential for the good functioning of the transmission line and for maximizing the effect on the plasma. This thesis gives all necessary tools for finding the proportion of the fundamental mode and all other modes present in passive components and at the output of the gyrotron as installed in the Tore Supra ECRH plant. This characterisation is based on obtaining amplitude and phase diagrams of the electric field on a plane transverse to the propagation axis. The most difficult part of obtaining these diagrams is measuring the phase which, despite the very short wavelength, is measured directly at low power levels. At high power levels the phase is numerically reconstructed from amplitude measurements for gyrotron characterisation. A complete theoretical study of the phase reconstruction code is given including its validation with theoretical diagrams. This study allows the realisation of a modal characterisation unit electromagnetic for measurement of radiated beams and usable in each part of the ECRH installation. At the end, the complete modal characterisation is given at low level for a mode converter and also at high level for the first series gyrotron installed at TORE SUPRA. (author)

  10. Upgrades for the ECH System on DIII-D

    Science.gov (United States)

    Lohr, J.; Cengher, M.; Doane, J. L.; Gorelov, Y. A.; Moeller, C. P.; Ponce, D.; Noraky, S.; Penaflor, B. G.; Kolemen, E.

    2012-10-01

    The gyrotron system for electron cyclotron heating on the DIII-D tokamak is being upgraded with the addition of higher efficiency gyrotrons having collector potential depression. Two new gyrotrons, operating at the present frequency of 110 GHz and generating 1.2 MW per unit, have been manufactured and are being installed and tested. The subsequent group of gyrotrons have been designed to generate 1.5 MW for 10 s pulses at 117.5 GHz. The first of these tubes is presently being manufactured at Communications and Power Industries. By the end of 2013, the system will comprise eight high power gyrotrons and, pending the successful performance of the 1.5 MW tube, an upgrade to a 15 MW system will begin. High voltage power supplies, transmission lines, launchers and associated control and data acquisition systems are included in the upgrades as is enhanced ability to steer the rf beams under a variety of pre-programed and reactive scenarios.

  11. Initial results for a 170 GHz high power ITER waveguide component test stand

    Science.gov (United States)

    Bigelow, Timothy; Barker, Alan; Dukes, Carl; Killough, Stephen; Kaufman, Michael; White, John; Bell, Gary; Hanson, Greg; Rasmussen, Dave

    2014-10-01

    A high power microwave test stand is being setup at ORNL to enable prototype testing of 170 GHz cw waveguide components being developed for the ITER ECH system. The ITER ECH system will utilize 63.5 mm diameter evacuated corrugated waveguide and will have 24 >150 m long runs. A 170 GHz 1 MW class gyrotron is being developed by Communications and Power Industries and is nearing completion. A HVDC power supply, water-cooling and control system has been partially tested in preparation for arrival of the gyrotron. The power supply and water-cooling system are being designed to operate for >3600 second pulses to simulate the operating conditions planned for the ITER ECH system. The gyrotron Gaussian beam output has a single mirror for focusing into a 63.5 mm corrugated waveguide in the vertical plane. The output beam and mirror are enclosed in an evacuated duct with absorber for stray radiation. Beam alignment with the waveguide is a critical task so a combination of mirror tilt adjustments and a bellows for offsets will be provided. Analysis of thermal patterns on thin witness plates will provide gyrotron mode purity and waveguide coupling efficiency data. Pre-prototype waveguide components and two dummy loads are available for initial operational testing of the gyrotron. ORNL is managed by UT-Battelle, LLC, for the U.S. Dept. of Energy under Contract DE-AC-05-00OR22725.

  12. Dust Emission from High-Redshift QSOs.

    Science.gov (United States)

    Carilli; Bertoldi; Menten; Rupen; Kreysa; Fan; Strauss; Schneider; Bertarini; Yun; Zylka

    2000-04-10

    We present detections of emission at 250 GHz (1.2 mm) from two high-redshift QSOs from the Sloan Digital Sky Survey sample using the bolometer array at the IRAM 30 m telescope. The sources are SDSSp 015048.83+004126.2 at z=3.7 and SDSSp J033829.31+002156.3 at z=5.0; the latter is the third highest redshift QSO known and the highest redshift millimeter-emitting source yet identified. We also present deep radio continuum imaging of these two sources at 1.4 GHz using the Very Large Array. The combination of centimeter and millimeter observations indicate that the 250 GHz emission is most likely thermal dust emission, with implied dust masses approximately 108 M middle dot in circle. We consider possible dust heating mechanisms, including UV emission from the active galactic nucleus (AGN) and a massive starburst concurrent with the AGN, with implied star formation rates greater than 103 M middle dot in circle yr-1. PMID:10727380

  13. Far-infrared and Molecular CO Emission From the Host Galaxies of Faint Quasars at z~6

    CERN Document Server

    Wang, Ran; Carilli, Chris L; Neri, Roberto; Walter, Fabian; Omont, Alain; Riechers, Dominik A; Bertoldi, Frank; Menten, Karl M; Cox, Pierre; Strauss, Michael A; Fan, Xiaohui; Jiang, Linhua

    2011-01-01

    We present new millimeter and radio observations of nine z~6 quasars discovered in deep optical and near-infrared surveys. We observed the 250 GHz continuum in eight of the nine objects and detected three of them. New 1.4 GHz radio continuum data have been obtained for four sources, and one has been detected. We searched for molecular CO (6-5) line emission in the three 250 GHz detections and detected two of them. We study the FIR and radio emission and quasar-host galaxy evolution with a sample of 18 z~6 quasars that are faint at UV/optical wavelengths (rest-frame 1450A magnitudes of m_1450\\ge20.2). The average FIR-to-AGN UV luminosity ratio of this faint quasar sample is about two times higher than that of the bright quasars at z~6 (m_1450<20.2). A fit to the average FIR and AGN bolometric luminosities of both the UV/optically faint and bright z~6 quasars, and the average luminosities of samples of submillimeter /millimeter-observed quasars at z~2 to 5, yields a relationship of L_{FIR} {L_{bol}}^{0.62}. ...

  14. Inhibitory effect of dendroaspis natriuretic peptide on spontaneous contraction in gastric antral circular smooth muscles of guinea pigs

    Institute of Scientific and Technical Information of China (English)

    Hui-shu GUO; Zheng-xu CAI; Tai-hua WU; Jing XU; Yang QIU; Wen-xie XU

    2007-01-01

    Aim:To determine whether the natriuretic peptide receptor (NPR) is present in the stomach of guinea pigs and to investigate the effect of dendroaspis natriuretic peptide (DNP) on the gastric motility of guinea pigs and its mechanism. Methods:The distribution of the NPR was analyzed by autoradioimmunography. The spontaneous contraction of gastric antral circular muscles of guinea pigs was recorded by a 4-channel physiograph. The whole cell patch-clamp technique was introduced to record calcium-activated potassium currents in the gastric myocytes isolated by collagenase. Results:The NPR existed in the gastric fundus,gastric body,and gastric antrum of guinea pigs,and its density was largest in the gastric antrum. DNP inhibited spontaneous contraction and exhibited a dose-dependent manner. The DNP-induced inhibition was diminished by LY83583 (a guanylate cyclase inhibitor) and was potentiated by zaprinast (a cGMP-sensitive phosphoesterase inhibitor). The inhibitory effect of DNP on spontaneous contraction was also inhibited by tetraethylammonium (a non-selective potassium channel blocker);10 nmol/L DNP increased the calcium-activated potassium currents in the gastric circular myocytes of guinea pigs. Conclusion:The NPR is most common in the gastric antrum of guinea pigs. DNP significantly inhibits gastric motility in the gastric antrum of guinea pigs. The inhibitory effect occurs via a cGMP-dependent pathway,and a calcium-activated potassium channel may be also involved in the relaxation induced by DNP in gastric antral circular smooth muscles.

  15. Impact of Ho(3+)-doping on (13)C dynamic nuclear polarization using trityl OX063 free radical.

    Science.gov (United States)

    Kiswandhi, Andhika; Niedbalski, Peter; Parish, Christopher; Kaur, Pavanjeet; Martins, André; Fidelino, Leila; Khemtong, Chalermchai; Song, Likai; Sherry, A Dean; Lumata, Lloyd

    2016-08-21

    We have investigated the effects of Ho-DOTA doping on the dynamic nuclear polarization (DNP) of [1-(13)C] sodium acetate using trityl OX063 free radical at 3.35 T and 1.2 K. Our results indicate that addition of 2 mM Ho-DOTA on 3 M [1-(13)C] sodium acetate sample in 1 : 1 v/v glycerol : water with 15 mM trityl OX063 improves the DNP-enhanced (13)C solid-state nuclear polarization by a factor of around 2.7-fold. Similar to the Gd(3+) doping effect on (13)C DNP, the locations of the positive and negative (13)C maximum polarization peaks in the (13)C microwave DNP sweep are shifted towards each other with the addition of Ho-DOTA on the DNP sample. W-band electron spin resonance (ESR) studies have revealed that while the shape and linewidth of the trityl OX063 ESR spectrum was not affected by Ho(3+)-doping, the electron spin-lattice relaxation time T1 of trityl OX063 was prominently reduced at cryogenic temperatures. The reduction of trityl OX063 electron T1 by Ho-doping is linked to the (13)C DNP improvement in light of the thermodynamic picture of DNP. Moreover, the presence of Ho-DOTA in the dissolution liquid at room temperature has negligible reduction effect on liquid-state (13)C T1, in contrast to Gd(3+)-doping which drastically reduces the (13)C T1. The results here suggest that Ho(3+)-doping is advantageous over Gd(3+) in terms of preservation of hyperpolarized state-an important aspect to consider for in vitro and in vivo NMR or imaging (MRI) experiments where a considerable preparation time is needed to administer the hyperpolarized (13)C liquid. PMID:27424954

  16. Remote Control System of the TJ-II Microwave Transmission Lines Mirrors

    International Nuclear Information System (INIS)

    The ECRH system of the TJ-II stellarator has two gyrotrons, which deliver a maximum power of 300 kW each at a frequency of 53.2 GHz. Another 28 GHz gyrotron will be used to heat the plasma by electron Bernstein waves (EBWH). The microwave power is transmitted from the gyrotrons to the vacuum chamber by two quasi-optical transmission lines for ECRH and a corrugated waveguide for EBWH. All transmission lines have an internal movable mirror inside the vacuum chamber to focus the beam and to be able to change the launching angle. The control of the beam polarization is very important and the lines have two corrugated mirrors, which actuate as polarizers. In this report the control system of the position of these three internal mirrors and the polarizers of the EBWH transmission line is described. (Author) 20 refs

  17. Fundamental mode rectangular waveguide system for electron-cyclotron resonant heating (ECRH) for tandem mirror experiment-upgrade (TMX-U)

    International Nuclear Information System (INIS)

    We present a brief history of TMX-U's electron cyclotron resonant heating (ECRH) progress. We emphasize the 2-year performance of the system, which is composed of four 200-kW pulsed gyrotrons operated at 28 GHz. This system uses WR42 waveguide inside the vacuum vessel, and includes barrier windows, twists, elbows, and antennas, as well as custom-formed waveguides. Outside the TMX-U vessel are directional couplers, detectors, elbows, and waveguide bends in WR42 rectangular waveguide. An arc detector, mode filter, eight-arm mode converter, and water load in the 2.5-in. circular waveguide are attached directly to the gyrotron. Other specific areas discussed include the operational performance of the TMX-U pulsed gyrotrons, windows and component arcing, alignment, mode generation, and extreme temperature variations. Solutions for a number of these problems are described

  18. Status of the 140 GHz, 10 MW CW transmission system for ECRH on the stellarator W7-X

    International Nuclear Information System (INIS)

    The stellarator W7-X, which is currently under construction at IPP Greifswald, Germany, will be equipped with a 10 MW ECRH system working at 140 GHz in CW regime. The microwave power will be generated by 10 gyrotrons delivering 1 MW each and will be transmitted from the gyrotron hall to the W7-X stellarator ports via a fully optical system. The status of the construction of the transmission lines and the design of the launchers is reported. Low-power tests of a prototype system at IPF Stuttgart are reviewed. Now, the first two gyrotrons are operating at IPP Greifswald, and high-power long-pulse tests have started. Measurements on transmission performance, behaviour of the water-cooled mirrors under thermal and microwave loads as well as alignment issues, characteristics of directional couplers, calorimetric loads, and other diagnostics are discussed

  19. Remote Control System of the TJ-II Microwave Transmission Lines Mirrors; Sistema de Control Remoto de los Espejos de las Lineas de Transmision de Microondas del TJ-II

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Sanchez, A.; Fernandez, A.; Cappa, A.; Gama, J. de la; Olivares, J.; Garcia, R.; Chamorro, M.

    2007-09-27

    The ECRH system of the TJ-II stellarator has two gyrotrons, which deliver a maximum power of 300 kW each at a frequency of 53.2 GHz. Another 28 GHz gyrotron will be used to heat the plasma by electron Bernstein waves (EBWH). The microwave power is transmitted from the gyrotrons to the vacuum chamber by two quasi-optical transmission lines for ECRH and a corrugated waveguide for EBWH. All transmission lines have an internal movable mirror inside the vacuum chamber to focus the beam and to be able to change the launching angle. The control of the beam polarization is very important and the lines have two corrugated mirrors, which actuate as polarizers. In this report the control system of the position of these three internal mirrors and the polarizers of the EBWH transmission line is described. (Author) 20 refs.

  20. 3.6MW Power Supply System of the 170GHz ECH&CD System in KSTAR

    Science.gov (United States)

    Shim, Eun-yong; Ahn, Il-kun; Seo, Tae-won; Lee, Seung-kyo; Bae, Young-soon; Joung, Jin-Hyun; Joung, Mi

    2012-09-01

    A 3.6 MW (-66 kV/55 A) Gyrotron power supply system was developed for the 170 GHz ECH&CD gyrotron system in KSTAR. This power supply system consists of Cathode Power Supply(CPS), Anode Power Supply(APS) and Body Power Supply(BPS). The CPS is using the Pulse Step Modulation by the 32set of IGBT choppers. The respons time of Chopper is very fast. So the cathode voltaget is able to be controlled rapidly. The APS is a sort of voltage devider using zener and switch component. It was achieved 3kHz modulation operation. The BPS is combined the commercial power supply and special high voltage switches. It is very simple topology but 5kHz modulation was accomplished easily. Theses power supply system were installed and commissioned successfully in 2011. This paper presents the topology of the each power supply and test result for 170 GHz gyrotron in KSTAR.

  1. Evaluation of Baffle Fixes Film up Flow Sludge Blanket Filtration (BFUSBF System in Treatment of Wastewaters from Phenol and 2,4-Dinitrophenol Using Daphnia Magna Bioassay

    Directory of Open Access Journals (Sweden)

    Mohammad Javad Ghannadzadeh

    2016-02-01

    Full Text Available Background: Phenol and nitrophenol are common compounds found in different types of industrial wastewater known as serious threats to human health and natural environment. In this study, Daphnia magna was used to evaluate the effectiveness of "baffle fixes film up flow sludge blanket filtration" (BFUSBF system in elimination of phenolic compounds from water. Methods: D. magna cultures were used as toxicity index of phenol and 2,4-DNP mixtures after treatment by a pilot BFUSBF system which consisted of baffle in anoxic section and biofilm in aerobic sections. Initial concentrations were 312 mg/L phenol and 288 mg/L 2,4-dinitrophenol (2,4-DNP. Results: Bioassay tests showed that D. magna was influenced by the toxicity of phenol and 2,4 DNP mixtures. The comparison between the toxicity of initial phenol and 2,4-DNP mixtures and the output toxic unit (TU derived from BFUSBF treatment system showed that the TU of the effluent from BFUSBF reactor was much lower than that of the solution that entered the reactor. Conclusion: Based on the acute toxicity test, BFUSBF process could reduce phenol and 2,4-DNP in aqueous solutions. Therefore, it is possible to use BFUSBF process as an appropriate treatment option for wastewaters containing phenolic compounds.

  2. Dynamic Nuclear Polarization as Kinetically Constrained Diffusion.

    Science.gov (United States)

    Karabanov, A; Wiśniewski, D; Lesanovsky, I; Köckenberger, W

    2015-07-10

    Dynamic nuclear polarization (DNP) is a promising strategy for generating a significantly increased nonthermal spin polarization in nuclear magnetic resonance (NMR) and its applications that range from medicine diagnostics to material science. Being a genuine nonequilibrium effect, DNP circumvents the need for strong magnetic fields. However, despite intense research, a detailed theoretical understanding of the precise mechanism behind DNP is currently lacking. We address this issue by focusing on a simple instance of DNP-so-called solid effect DNP-which is formulated in terms of a quantum central spin model where a single electron is coupled to an ensemble of interacting nuclei. We show analytically that the nonequilibrium buildup of polarization heavily relies on a mechanism which can be interpreted as kinetically constrained diffusion. Beyond revealing this insight, our approach furthermore permits numerical studies of ensembles containing thousands of spins that are typically intractable when formulated in terms of a quantum master equation. We believe that this represents an important step forward in the quest of harnessing nonequilibrium many-body quantum physics for technological applications. PMID:26207453

  3. Enthalpy-entropy compensation in dinitrophenyl--anti-dinitrophenyl antibody interaction(s).

    Science.gov (United States)

    Szewczuk, M R; Mukkur, T K

    1977-02-01

    The effect of varying the temperature over a wide range (-3 dergees -67 degrees) on the binding of xi-DNP-L-Lysine to bovine colostral anti-DNA IgG1, and also rabbit anti-DNP IgG revealed non-linear van't Hoff plots. The extent of the curvatures were found to be indicative of large positive heat capacity changes; and the thermodynamic parameters, calculated using a non-linear least-squares computer procedure for these anti-DNP antibody preparations, revealed an enthalpy-entropy compensation mechanism for hapten-antibody binding. The enthalpy factor was found to be the primary contributor for the binding process at low temperatures, but at increasing temperatures the entropy factor assumed greater importance. At physiological temperature (37 degrees), the entropy factor was the major contributor to the free energy of reaction for rabbit anti-DNP IgG, while for bovine colostral anti-DNP IgG it was predominant at temperatures higher than 37 degrees.

  4. Carbon Nanofiber/3D Nanoporous Silicon Hybrids as High Capacity Lithium Storage Materials.

    Science.gov (United States)

    Park, Hyeong-Il; Sohn, Myungbeom; Kim, Dae Sik; Park, Cheolho; Choi, Jeong-Hee; Kim, Hansu

    2016-04-21

    Carbon nanofiber (CNF)/3D nanoporous (3DNP) Si hybrid materials were prepared by chemical etching of melt-spun Si/Al-Cu-Fe alloy nanocomposites, followed by carbonization using a pitch. CNFs were successfully grown on the surface of 3DNP Si particles using residual Fe impurities after acidic etching, which acted as a catalyst for the growth of CNFs. The resulting CNF/3DNP Si hybrid materials showed an enhanced cycle performance up to 100 cycles compared to that of the pristine Si/Al-Cu-Fe alloy nanocomposite as well as that of bare 3DNP Si particles. These results indicate that CNFs and the carbon coating layer have a beneficial effect on the capacity retention characteristics of 3DNP Si particles by providing continuous electron-conduction pathways in the electrode during cycling. The approach presented here provides another way to improve the electrochemical performances of porous Si-based high capacity anode materials for lithium-ion batteries. PMID:26970098

  5. 300 GHz ジャイロトロンを用いた材料処理装置の開発

    OpenAIRE

    佐古, 勝英; 谷, 晋仁; 橋本, 秀一; 尾関, 隆則; 光藤, 誠太郎; 立松, 芳典; 斉藤, 輝雄; 出原, 敏孝; SAKO, Katsuhide; TANI, Shinji; HASHIMOTO, Syuiti; Ozeki, Takanori; MITSUDO, Seitaro; TATEMATSU, Yoshinori; SAITO, Teruo

    2010-01-01

    The effective characteristics of high frequency and strong electric field processing wereobserved. One of the interesting effects is the so-called non-thermal effect or microwave effect. In order to widely study the non-thermal effect of ceramics sintering and application of material processing, we developed a material processing system by using the 300 GHz gyrotron FU CW I. This system consists of a 300GHz, 2.3 kW, CW gyrotron with a cryogen free 12 T superconducting magnet, a corrugated cir...

  6. Recent progresses in the 110 GHz ECRF system on JT-60U tokamak

    International Nuclear Information System (INIS)

    The 110 GHz ECRF system on the JT-60U started its operation with a 1 MW gyrotron in 1999. Two additional units were completed in 2000. The forth unit was available to generate the total power of 4 MW in 2001. The 1 MW gyrotron is featured by a collector potential depression structure and a diamond output window. The system has four evacuated waveguide lines in 50-60 m length with nine miter bends, each of which has a diamond window near the antenna. One of the recent progresses in this system is to up-grade the gyrotron, whose previous performance was limited to less than 1 MW x 2 sec by a parasitic oscillation in it. Three of four gyrotrons were improved for suppression of the parasitic oscillation by installing a RF absorber in the beam tunnel. The second progress is to reduce the fluctuation in the acceleration voltage for the high power gyrotron operation. The main DC voltage power supply for the gyrotron is not regulated in the system. Before this progress, a large fluctuation in the DC voltage disturbed the stable gyrotron oscillation when four gyrotrons were simultaneously in operation. The third progress is to improve the transmission efficiency from 60-75% to 70-80% by re-adjusting the alignment of the waveguide lines. By these progresses, a generated power on the best unit has reached up to ∼ 1.2 MW x 4.1 s (∼ 1 MW x 5 s) corresponding to ∼ 1 MW (∼ 0.8 MW) for the injected power into plasmas. The total injected power has been 3 MW x 2 sec (∼ 2.8 MW x 3.6 s) using four units. A local profile control has been performed using two steerable antennas at this power level during a plasma discharge. The test of the feedback control of the steerable antenna linked with the perturbation of electron temperature has been successfully done for stabilization the MHD instability such as NTM. (authors)

  7. High power test of a wideband diplexer with short-slotted metal half mirrors for electron cyclotron current drive system

    International Nuclear Information System (INIS)

    The wideband high power diplexer has been developed for combining and fast switching of high power millimeter waves generated by a dual frequency gyrotron. The actual diplexer was tested at the frequency band of 170 GHz in low power. After adjusting a resonant frequency of diplexer for the gyrotron frequency, the evacuated wideband diplexer with short-slotted metal half mirrors was tested at an incident power of about 150 kW, a pulse duration of 30 ms and a frequency band of 170.2–170.3 GHz. Any discharge damage was not observed in the diplexer

  8. Commissioning activities and first results from the collective Thomson scattering diagnostic on ASDEX Upgrade (invited)

    DEFF Research Database (Denmark)

    Meo, Fernando; Bindslev, Henrik; Korsholm, Søren Bang;

    2008-01-01

    The collective Thomson scattering (CTS) diagnostic installed on ASDEX Upgrade uses millimeter waves generated by the newly installed 1 MW dual frequency gyrotron as probing radiation at 105 GHz. It measures backscattered radiation with a heterodyne receiver having 50 channels (between 100 and 110...... of the diagnostic. It then describes the commissioning activities carried out to date. These activities include gyrotron studies, transmission line alignment, and beam pattern measurements in the vacuum vessel. Overlap experiments in near perpendicular and near parallel have confirmed the successful alignment...

  9. Producing Radical-Free Hyperpolarized Perfusion Agents for In Vivo Magnetic Resonance Using Spin-Labeled Thermoresponsive Hydrogel.

    Science.gov (United States)

    Cheng, Tian; Mishkovsky, Mor; Junk, Matthias J N; Münnemann, Kerstin; Comment, Arnaud

    2016-07-01

    Dissolution dynamic nuclear polarization (DNP) provides a way to tremendously improve the sensitivity of nuclear magnetic resonance experiments. Once the spins are hyperpolarized by dissolution DNP, the radicals used as polarizing agents become undesirable since their presence is an additional source of nuclear spin relaxation and their toxicity might be an issue. This study demonstrates the feasibility of preparing a hyperpolarized [1-(13) C]2-methylpropan-2-ol (tert-butanol) solution free of persistent radicals by using spin-labeled thermoresponsive hydrophilic polymer networks as polarizing agents. The hyperpolarized (13) C signal can be detected for up to 5 min before the spins fully relax to their thermal equilibrium. This approach extends the applicability of spin-labeled thermoresponsive hydrogel to the dissolution DNP field and highlights its potential as polarizing agent for preparing neat slowly relaxing contrast agents. The hydrogels are especially suited to hyperpolarize deuterated alcohols which can be used for in vivo perfusion imaging. PMID:27184565

  10. Environmental conditions influence the plant functional diversity effect on potential denitrification.

    Directory of Open Access Journals (Sweden)

    Ariana E Sutton-Grier

    Full Text Available Global biodiversity loss has prompted research on the relationship between species diversity and ecosystem functioning. Few studies have examined how plant diversity impacts belowground processes; even fewer have examined how varying resource levels can influence the effect of plant diversity on microbial activity. In a field experiment in a restored wetland, we examined the role of plant trait diversity (or functional diversity, (FD and its interactions with natural levels of variability of soil properties, on a microbial process, denitrification potential (DNP. We demonstrated that FD significantly affected microbial DNP through its interactions with soil conditions; increasing FD led to increased DNP but mainly at higher levels of soil resources. Our results suggest that the effect of species diversity on ecosystem functioning may depend on environmental factors such as resource availability. Future biodiversity experiments should examine how natural levels of environmental variability impact the importance of biodiversity to ecosystem functioning.

  11. Development on dynamic nuclear polarized targets.

    Energy Technology Data Exchange (ETDEWEB)

    Penttila, S. I. (Seppo I.)

    2002-01-01

    Our interest in understanding the spin content of the nucleon has left its marks on the recent development, of the dynamic nuclear polarized (DNP) targets. This can be seen from the targets developed at CERN and SLAC for the measurement of the polarized spin structure functions in deep inelastic scattering. The results of the experiments indicated that less than 30% of the nucleon spin is carried by the quarks. This unpredicted small value initiated planning of new polarized target experiments to determine the gluon polarization on the nucleon using polarized real photons and polarized 'LiD targets. In several facilities very intense polarized photon beams are available at a wide energy range. During the next few years these photon beanis with DNP targets will be used to test the fundamental GDH sum rule. Other DNP target developments are also discussed.

  12. The Doctor of Nursing Practice: defining the next steps.

    Science.gov (United States)

    Grey, Margaret

    2013-08-01

    The purpose of this article is to summarize the previous articles in this special issue of the Journal of Nursing Education that are based on the Committee on Institutional Cooperation's Dean's Conference on the Doctor of Nursing Practice (DNP) and to identify areas of consensus, as well as areas of controversy. Areas of consensus include the high level of interest in DNP programs and the intent to expand the role of the advanced practice nurse to population health, policy, and leadership. Areas of controversy include the nature of the DNP product, the definition of clinical experiences, the nature of the capstone project, the outcomes of these new practitioners, and the impact on schools. Suggestions for achieving higher levels of consensus, including the need for respective, inclusive dialogue, are provided. PMID:23875725

  13. H-1 Dynamic Nuclear Polarization in Supercritical Ethylene at 1.4 T

    Energy Technology Data Exchange (ETDEWEB)

    Wind, Robert A.(BATTELLE (PACIFIC NW LAB)); Shi, Bai (PNNL); Hu, Jian Zhi (BATTELLE (PACIFIC NW LAB)); Solum, Mark S.(Utah, Univ Of); Ellis, Paul D.(BATTELLE (PACIFIC NW LAB)); Grant, David M.(Utah, Univ Of); Pugmire, Ronald J.(Utah, Univ Of); Taylor, Craig M.(DOE); Yonker, Clement R.(BATTELLE (PACIFIC NW LAB))

    2000-03-01

    H1 dynamic nuclear polarization (DNP) has been measured in supercritical ethylene in the pressure range 60-300 bar and in an external field of 1.4 T. A single-cell sapphire tube was used as a high pressure cell and powdered 1,3-bisdiphenylene-2-phenyl allyl(BDPA) free radicals were added and distributed at the wall of the cell. At all pressures the dominant DNP effect was a positive Overhauser enhancement, caused by proton-electron contact interactions at the fluid/solid radical interface. The observed enhancements varied from 12 at 67 bar to 17 at 300 bar. Besides the Overhauser enhancement, also a small solid state and thermal mixing enhancement were observed, indicating that part of the ethylene is absorbed at the radical surface for a prolonged time. These data indicate that DNP-enhanced NMR has the potential of extending the impact of NMR in research areas involving supercritical fluids.

  14. Solid-state NMR enhanced by dynamic nuclear polarization as a novel tool for ribosome structural biology

    Energy Technology Data Exchange (ETDEWEB)

    Gelis, Ioannis [University of South Florida, Department of Chemistry (United States); Vitzthum, Veronika [Ecole Polytechnique Federale de Lausanne, Institut des Sciences et Ingenierie Chimiques (Switzerland); Dhimole, Neha [Goethe University Frankfurt, Buchmann Institute for Molecular Life Sciences, Institute of Organic Chemistry and Chemical Biology (Germany); Caporini, Marc A. [Ecole Polytechnique Federale de Lausanne, Institut des Sciences et Ingenierie Chimiques (Switzerland); Schedlbauer, Andreas [Goethe University Frankfurt, Buchmann Institute for Molecular Life Sciences, Institute of Organic Chemistry and Chemical Biology (Germany); Carnevale, Diego [Ecole Polytechnique Federale de Lausanne, Institut des Sciences et Ingenierie Chimiques (Switzerland); Connell, Sean R.; Fucini, Paola, E-mail: pfucini@cicbiogune.es [Goethe University Frankfurt, Buchmann Institute for Molecular Life Sciences, Institute of Organic Chemistry and Chemical Biology (Germany); Bodenhausen, Geoffrey, E-mail: geoffrey.bodenhausen@epfl.ch [Ecole Polytechnique Federale de Lausanne, Institut des Sciences et Ingenierie Chimiques (Switzerland)

    2013-06-15

    The impact of Nuclear Magnetic Resonance (NMR) on studies of large macromolecular complexes hinges on improvements in sensitivity and resolution. Dynamic nuclear polarization (DNP) in the solid state can offer improved sensitivity, provided sample preparation is optimized to preserve spectral resolution. For a few nanomoles of intact ribosomes and an 800 kDa ribosomal complex we demonstrate that the combination of DNP and magic-angle spinning NMR (MAS-NMR) allows one to overcome current sensitivity limitations so that homo- and heteronuclear {sup 13}C and {sup 15}N NMR correlation spectra can be recorded. Ribosome particles, directly pelleted and frozen into an NMR rotor, yield DNP signal enhancements on the order of {approx}25-fold and spectra that exhibit narrow linewidths, suitable for obtaining site-specific information. We anticipate that the same approach is applicable to other high molecular weight complexes.

  15. Electron spin dynamics and spin-lattice relaxation of trityl radicals in frozen solutions.

    Science.gov (United States)

    Chen, Hanjiao; Maryasov, Alexander G; Rogozhnikova, Olga Yu; Trukhin, Dmitry V; Tormyshev, Victor M; Bowman, Michael K

    2016-09-28

    Electron spin-lattice relaxation of two trityl radicals, d24-OX063 and Finland trityl, were studied under conditions relevant to their use in dissolution dynamic nuclear polarization (DNP). The dependence of relaxation kinetics on temperature up to 100 K and on concentration up to 60 mM was obtained at X- and W-bands (0.35 and 3.5 Tesla, respectively). The relaxation is quite similar at both bands and for both trityl radicals. At concentrations typical for DNP, relaxation is mediated by excitation transfer and spin-diffusion to fast-relaxing centers identified as triads of trityl radicals that spontaneously form in the frozen samples. These centers relax by an Orbach-Aminov mechanism and determine the relaxation, saturation and electron spin dynamics during DNP. PMID:27560644

  16. Identification of oxidised proteins in the matrix of rice leaf mitochondria by immunoprecipitation and two-dimensional liquid chromatography-tandem mass spectrometry

    DEFF Research Database (Denmark)

    Kristensen, B.K.; Askerlund, P.; Bykova, N.V.;

    2004-01-01

    blots showed that neither the isolation of mitochondria, nor their subfractionation introduced carbonyl groups. We therefore conclude that a number of proteins are oxidised in the matrix of rice leaf mitochondria in vivo and further identify a group of proteins that are particularly susceptible to mild......Highly purified mitochondria were isolated from green 7-day-old rice leaves. The mitochondria were sonicated and the matrix fraction isolated as the 100,000g supernatant. Part of the matrix fraction was left untreated while the other part was subjected to a mild oxidative treatment (0.5 mM H2O2 + 0.......2 mM CuSO4 for 10 min at room temperature). The oxidised proteins in both samples were tagged with dinitrophenylhydrazine (DNP), which forms a covalent bond with carbonyl groups. The DNP-tagged proteins were immunoprecipitated using anti-DNP antibodies and digested with trypsin. The mixture of...

  17. Metabolism of acyclic and cyclic N-nitrosamines in cultured human bronchi

    DEFF Research Database (Denmark)

    1977-01-01

    ,N'-dinitrosopiperazine (DNP), N-nitrosopyrrolidine (NPy), and N-nitrosopiperidine (NPd)] labeled with 14C were each then added at 100 mumoles for 24 hours. Measurable CO2 was formed by bronchial explants from: 1) DMN, DEN, and NPy in all 4 patients; 2) DNP in 3 of 4 patients; and 3) NPd in only 1 of 4 patients. In all...... bronchial specimens, these N-nitrosamines and/or their metabolites bound to bronchial mucosal DNA and protein. Binding levels were higher to protein than to DNA. Binding levels of DNP were as high as those with the two acyclic N-nitrosamines DMN and DEN, but binding levels of NPy and NPd were lower. Human...

  18. On The Potential of Dynamic Nuclear Polarization Enhanced Diamonds in Solid-State and Dissolution (13) C NMR Spectroscopy

    DEFF Research Database (Denmark)

    Bretschneider, Christian O; Akbey, Ümit; Aussenac, Fabien;

    2016-01-01

    Dynamic nuclear polarization (DNP) is a versatile option to improve the sensitivity of NMR and MRI. This versatility has elicited interest for overcoming potential limitations of these techniques, including the achievement of solid-state polarization enhancement at ambient conditions, and the...... environments ranging from cryogenic to ambient temperatures, in both solution and solid-state experiments. It was found that (13) C NMR signals could be boosted by orders of magnitude in either low- or room-temperature solid-state DNP experiments by utilizing naturally occurring paramagnetic P1 substitutional......) C Zeeman splitting. The efficiency of this solid-state polarization process, however, is harder to exploit in dissolution DNP-enhanced MRI contexts. The prospects for utilizing polarized diamond approaching nanoscale dimensions for both solid and solution applications are briefly discussed....

  19. Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy.

    Directory of Open Access Journals (Sweden)

    Katalin Susztak

    2005-02-01

    Full Text Available BACKGROUND: Diabetic nephropathy (DNP is a common complication of type 1 and type 2 diabetes mellitus and the most common cause of kidney failure. While DNP manifests with albuminuria and diabetic glomerulopathy, its progression correlates best with tubular epithelial degeneration (TED and interstitial fibrosis. However, mechanisms leading to TED in DNP remain poorly understood. METHODS AND FINDINGS: We found that expression of scavenger receptor CD36 coincided with proximal tubular epithelial cell (PTEC apoptosis and TED specifically in human DNP. High glucose stimulated cell surface expression of CD36 in PTECs. CD36 expression was necessary and sufficient to mediate PTEC apoptosis induced by glycated albumins (AGE-BSA and CML-BSA and free fatty acid palmitate through sequential activation of src kinase, and proapoptotic p38 MAPK and caspase 3. In contrast, paucity of expression of CD36 in PTECs in diabetic mice with diabetic glomerulopathy was associated with normal tubular epithelium and the absence of tubular apoptosis. Mouse PTECs lacked CD36 and were resistant to AGE-BSA-induced apoptosis. Recombinant expression of CD36 in mouse PTECs conferred susceptibility to AGE-BSA-induced apoptosis. CONCLUSION: Our findings suggest a novel role for CD36 as an essential mediator of proximal tubular apoptosis in human DNP. Because CD36 expression was induced by glucose in PTECs, and because increased CD36 mediated AGE-BSA-, CML-BSA-, and palmitate-induced PTEC apoptosis, we propose a two-step metabolic hit model for TED, a hallmark of progression in DNP.

  20. Generating highly polarized nuclear spins in solution using dynamic nuclear polarization

    DEFF Research Database (Denmark)

    Wolber, J.; Ellner, F.; Fridlund, B.;

    2004-01-01

    and other low-γ nuclei. Subsequent to the DNP process, the solid sample is dissolved rapidly with a warm solvent to create a solution of molecules with highly polarized nuclear spins. Two main applications are proposed: high-resolution liquid state NMR with enhanced sensitivity, and the use......A method to generate strongly polarized nuclear spins in solution has been developed, using Dynamic Nuclear Polarization (DNP) at a temperature of 1.2K, and at a field of 3.354T, corresponding to an electron spin resonance frequency of 94GHz. Trityl radicals are used to directly polarize 13C...

  1. Effect of 13C enrichment in the glassing matrix on dynamic nuclear polarization of [1-13C]pyruvate

    OpenAIRE

    Lumata, Lloyd; Kovacs, Zoltan; Malloy, Craig; Sherry, A. Dean; Merritt, Matthew

    2011-01-01

    Dimethyl sulfoxide (DMSO) can effectively form a glassy matrix necessary for dynamic nuclear polarization (DNP) experiments. We tested the effects of 13C enrichment in DMSO on DNP of [1-13C]pyruvate doped with trityl radical OX063Me. We found that the polarization build-up time τ of pyruvate in 13C-labelled DMSO glassing solution is twice as fast as the unenriched DMSO while the NMR enhancement was unchanged. This indicates that 13C-13C spin diffusion is a limiting factor in the kinetics of d...

  2. Dynamic nuclear polarization-magnetic resonance imaging at low ESR irradiation frequency for ascorbyl free radicals

    OpenAIRE

    Shinji Ito; Fuminori Hyodo

    2016-01-01

    Highly water-soluble ubiquinone-0 (CoQ0) reacts with ascorbate monoanion (Asc) to mediate the production of ascorbyl free radicals (AFR). Using aqueous reaction mixture of CoQ0 and Asc, we obtained positively enhanced dynamic nuclear polarization (DNP)-magnetic resonance (MR) images of the AFR at low frequency (ranging from 515 to 530 MHz) of electron spin resonance (ESR) irradiation. The shape of the determined DNP spectrum was similar to ESR absorption spectra with doublet spectral peaks. T...

  3. Theory for cross effect dynamic nuclear polarization under magic-angle spinning in solid state nuclear magnetic resonance: The importance of level crossings

    OpenAIRE

    Thurber, Kent R.; Tycko, Robert

    2012-01-01

    We present theoretical calculations of dynamic nuclear polarization (DNP) due to the cross effect in nuclear magnetic resonance under magic-angle spinning (MAS). Using a three-spin model (two electrons and one nucleus), cross effect DNP with MAS for electron spins with a large g-anisotropy can be seen as a series of spin transitions at avoided crossings of the energy levels, with varying degrees of adiabaticity. If the electron spin-lattice relaxation time T1e is large relative to the MAS rot...

  4. Cluster formation restricts dynamic nuclear polarization of xenon in solid mixtures

    DEFF Research Database (Denmark)

    Kuzma, N. N.; Pourfathi, M.; Kara, H.;

    2012-01-01

    During dynamic nuclear polarization (DNP) at 1.5 K and 5 T, Xe-129 nuclear magnetic resonance (NMR) spectra of a homogeneous xenon/1-propanol/trityl-radical solid mixture exhibit a single peak, broadened by H-1 neighbors. A second peak appears upon annealing for several hours at 125 K. Its....... Subsequent DNP system modifications designed to reduce the overheating resulted in four-fold increase of Xe-129 polarization, from 5.3% to 21%. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4751021]...

  5. A uranium (VI) complex: Synthesis, structural and thermal kinetic analysis

    Science.gov (United States)

    Goel, Nidhi

    2016-08-01

    A new complex [UO2(2,6-DNP)2phen] (1) (2,6-DNP = 2,6-dinitrophenol, phen = 1,10-phenanthroline) was synthesized, and identified by elemental analysis, IR, Powder XRD and single crystal X-ray crystallography. Crystal structure provides the abundant information's about the bonding and geometry around the U(VI) metal center. The thermal decomposition was studied by TG-DSC, and the kinetics of thermolysis was investigated by applying model fitting as well as isoconversional methods. Explosion delay measurement (De) was also evaluated to determine the response of this complex under the condition of rapid heating.

  6. Responses of medullary reticular formation neurons to input from the male genitalia.

    Science.gov (United States)

    Hubscher, C H; Johnson, R D

    1996-10-01

    1. The medullary reticular formation (MRF) is known to be involved in the modulation of certain reproductive behaviors. Ejaculation in the male, disrupted after spinal transection, may depend on a spinal-bulbo-spinal connection. To determine whether single neurons in the MRF receive sensory input from the male genitalia, the present study was undertaken using electrophysiological techniques. 2. The MRF of 14 urethan-anesthetized mature male rats was searched for single neurons responsive to bilateral electrical stimulation of the dorsal nerve of the penis (DNP). In addition, each DNP-responsive neuron was tested for responsiveness to bilateral electrical stimulation of the pelvic nerve (PN) and to mechanical stimulation (gentle touch, pressure, pinch) of the external genitalia, anus, urethra, and skin over most regions of the body. 3. A total of 165 single neurons responsive to bilateral electrical stimulation of the DNP were isolated and characterized throughout the MRF. All neurons responded to both ipsilateral and contralateral DNP stimulation. The majority of responses were excitatory, and most neurons had no background activity. Some neurons required wind-up with bilateral electrical stimulation of the DNP to respond. 4. About half of the neurons were located in the nucleus reticularis gigantocellularis (Gi); the remainder were located in surrounding (dorsal, ventral, lateral) regions of the MRF. Variations in response properties were found among neurons located in different MRF regions. 5. Eighty-eight DNP-responsive neurons were additionally responsive to bilateral electrical stimulation of the PN. None of the responses to bilateral PN were stronger than those for bilateral DNP and many (48%) were weaker. 6. Of the 165 DNP-responsive neurons, all were responsive to pressure/pinching of the penis; 16% responded to gentle stroking of the glans. Most of these neurons were additionally responsive (bilaterally) to pinching more than one (often all) of the

  7. Innovación en hidrocarburos en Colombia

    OpenAIRE

    Juan Benavides Estévez-Bretón

    2011-01-01

    Este artículo presenta parte del Proyecto DNP- Uniandes sobre Clusters en la industria minero energética. El análisis se centrará en la innovación en hidrocarburos: primero, el planteamiento básico; segundo, los retos y oportunidades, y tercero, las líneas de acción en las que Colombia puede trabajar.//This article presents a fragment of the DNP- Uniandes project on Clusters in the energy mining industry. Specifically, the analysis focuses on innovation in hydrocarbons, starting with the proj...

  8. Fusion development and technology

    International Nuclear Information System (INIS)

    This report discusses the following topics: superconducting magnet technology high field superconductors; advanced magnetic system and divertor development; poloidal field coils; gyrotron development; commercial reactor studies -- Aries; ITER physics; ITER superconducting PF scenario and magnet analysis; and safety, environmental and economic factors in fusion development

  9. Investigation of first mirror heating for the collective Thomson scattering diagnostic in ITER

    DEFF Research Database (Denmark)

    Salewski, Mirko; Meo, Fernando; Bindslev, Henrik;

    2008-01-01

    Collective Thomson scattering (CTS) has the capabilities to measure phase space densities of fast ion populations in ITER resolved in configuration space, in velocity space, and in time. In the CTS system proposed for ITER, probing radiation at 60 GHz generated by two 1 MW gyrotrons is scattered...

  10. 1990's annual report of INPE's Plasma Associated Laboratory

    International Nuclear Information System (INIS)

    This is the 1990's annual report of INPE's Plasma Associated Laboratory it contains information on current research developed at the laboratory including quiescent plasma, magnetized plasma, plasma centrifuge, plasma and radiation (gyrotron), ionic propulsion, and toroidal plasma. (A.C.A.S.)

  11. System using a megawatt class millimeter wave source and a high-power rectenna to beam power to a suspended platform

    Energy Technology Data Exchange (ETDEWEB)

    Caplan, Malcolm; Friedman, Herbert W.

    2005-07-19

    A system for beaming power to a high altitude platform is based upon a high power millimeter gyrotron source, optical transmission components, and a high-power receiving antenna (i.e., a rectenna) capable of rectifying received millimeter energy and converting such energy into useable electrical power.

  12. EC power sources: European technological developments towards ITER

    International Nuclear Information System (INIS)

    The activities in Europe towards the development of the EC power sources for ITER are centered on the development of a 170 GHz, 2 MW, CW coaxial cavity gyrotron of collector potential depressed (CPD) type. A gyrotron with a higher unit power than the ITER reference (1 MW) would yield a reduction of the installation costs, a more compact launcher design and, if required, an increase of the power delivered through one port. Tests proving the principle were successfully performed on a short-pulse experimental gyrotron delivering up to 2.2 MW in single mode. Following this success, a coordinated and fully consistent programme of development has been launched. The first industrial 2 MW prototype is now at an advanced stage of construction. The associated superconductive magnet producing 6.86 T on the cavity axis is also being procured. Dummy loads suitable for short and CW operation are also part of the development effort. Finally, a new EC test facility, with the features necessary for the testing of the gyrotron up to full power in CW, has been established and includes a fully solid-state power supply system

  13. Development and Preliminary Commissioning Results of a Long Pulse 140 GHz ECRH System on EAST Tokamak (Invited)

    Science.gov (United States)

    Xu, Handong; Wang, Xiaojie; Liu, Fukun; Zhang, Jian; Huang, Yiyun; Shan, Jiafang; Wu, Dajun; Hu, Huaichuan; Li, Bo; Li, Miaohui; Yang, Yong; Feng, Jianqiang; Xu, Weiye; Tang, Yunying; Wei, Wei; Xu, Liqing; Liu, Yong; Zhao, Hailin; Lohr, J.; A. Gorelov, Y.; P. Anderson, J.; Ma, Wendong; Wu, Zege; Wang, Jian; Zhang, Liyuan; Guo, Fei; Sun, Haozhang; Yan, Xinsheng; East Team

    2016-04-01

    A long pulse electron cyclotron resonance heating (ECRH) system has been developed to meet the requirements of steady-state operation for the EAST superconducting tokamak, and the first EC wave was successfully injected into plasma during the 2015 spring campaign. The system is mainly composed of four 140 GHz gyrotron systems, 4 ITER-Like transmission lines, 4 independent channel launchers and corresponding power supplies, a water cooling, control & inter-lock system etc. Each gyrotron is expected to deliver a maximum power of 1 MW and be operated at 100-1000 s pulse lengths. The No.1 and No.2 gyrotron systems have been installed. In the initial commissioning, a series of parameters of 1 MW 1 s, 900 kW 10 s, 800 kW 95 s and 650 kW 753 s have been demonstrated successfully on the No.1 gyrotron system based on calorimetric dummy load measurements. Significant plasma heating and MHD instability suppression effects were observed in EAST experiments. In addition, high confinement (H-mode) discharges triggered by ECRH were obtained. supported by the National Magnetic Confinement Fusion Science Program of China (Nos. 2011GB102000, 2012GB103000 and 2015GB103000)

  14. PERFORMANCE OF THE DIII-D SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    CALLIS,RW; KAJIWARA,K; LOHR,J; GORELOV,YA; PONCE,D

    2003-08-01

    A271 PERFORMANCE OF THE DIII-D SYSTEM. Three 110 GHz gyrotrons with nominal output power of 1 MW each have been installed and are operational on the DIII-D tokamak. All three gyrotrons were built by Communications and Power Industries (CPI). The CPI gyrotrons utilize a single disc CVD (chemical-vapor-deposition) diamond window that employs water cooling around the edge of the disc. Calculations predict that the CVD diamond window should be capable of full 1 MW cw operation, which is supported by IR camera measurements that show the window reaching equilibrium after 2.5 s. All gyrotrons are connected to the tokamak by low-loss-windowless evacuated transmission line using circular corrugated waveguide for propagation in the HE{sub 11} mode. Each waveguide system incorporates a two-mirror launcher, which can steer the rf beam poloidally from the center to the outer edge of the plasma. Results obtained using the DIII-D ECH systems will be reported.

  15. Spectrum response and analysis of 77 GHz band collective Thomson scattering diagnostic for bulk and fast ions in LHD plasmas

    DEFF Research Database (Denmark)

    Nishiura, M.; Kubo, S.; Tanaka, K.;

    2014-01-01

    cyclotron heating beam. To clarify the diagnostic applicability of the gyrotron in the 77 GHz frequency band, we investigated the dependence of the probe and receiver beam trajectories in plasmas with high electron densities of (4–5) × 1019 m−3 and low electron densities of (1–2) × 1019 m−3. At high density...

  16. Elmo Bumpy Torus proof of principle, Phase II: Title 1 report. Volume IV. Microwave system. Preliminary design report

    International Nuclear Information System (INIS)

    The EBT-P Microwave System provides microwaves for electron cyclotron resonance heating (ECRH) to both stabilize and heat the EBT-P plasma. A 28 gigahertz (GHz) system is required to form the hot electron annulus plasma that provides MHD stabilization to the core plasma. A 60 GHz system is required to heat the core plasma and will provide some second harmonic heating of the hot electron annulus. The principal microwave system elements and their design characteristics are summarized. The microwave system includes 200 kilowatt (kW) gyrotrons at 60 GHz for core heating and 200 kW gyrotrons at 28 GHz for annulus heating. The basic operating complement will be six (6) 60 GHz tubes and two (2) 28 GHz tubes. PACE (Plant and Capital Equipment) procurement will include four (4) 60 GHz gyrotrons with two (2) GHz tubes procured under operations and the two (2) 28 GHz tubes will be provided, with mounts, from the EBT-S program. Each tube is rigidly mounted on an oil filled tank assembly which provides electrical isolation and cooling. All tubes and mounts will be located in the lower level of the torus enclosure. An extensive demineralized water flow system is required to provide gyrotron cooling

  17. Fast ion millimeter wave collective Thomson scattering diagnostics on TEXTOR and ASDEX upgrades

    DEFF Research Database (Denmark)

    Michelsen, S.; Korsholm, Søren Bang; Bindslev, H.;

    2004-01-01

    Collective Thomson scattering (CTS) diagnostic systems for measuring fast ions in TEXTOR and ASDEX Upgrade are described in this article. Both systems use millimeter waves generated by gyrotrons as probing radiation and the scattered radiation is detected with heterodyne receivers having 40...

  18. Contributions to resolving issues impeding the operation of high power microwave devices

    Science.gov (United States)

    Kashyn, Dmytro

    This thesis reports an experimental study aimed at extending high power, high efficiency gyrotron operation to submillimeter wavelengths. A series of experiments carried out both at the University of Maryland and the Institute of Applied Physics of the Russian Academy of Science, succeeded in demonstrating output power at 670 GHz of 180 kilowatts with 20% efficiency (gyrotron voltage was 57 kV and beam current was 16 amperes). The maximum output power achieved in the experiments was 210kW at somewhat higher voltage and current (viz. 58kV and 22A). The achieved output power and efficiency are twice as large as achieved in previous experiments in this frequency range with pulse duration in the range of tens of microseconds. These performance parameters are relevant to a previously proposed application of detecting concealed radioactive materials by air breakdown in a focused beam of sub-millimeter radiation. The 670 GHz gyrotron combined features of two lines of previous experiments: (a) to operate at the required frequency, pulsed solenoids producing 28T magnetic were employed and (b) to obtain high efficiency a very high order mode was used in the gyrotron cavity, as in the experiments with gyrotrons for plasma heating. Evidence of multimode beating was observed in submillimeter output envelope. The excitation of spurious modes, especially during the rise of the gyrotron voltage pulse, was analyzed and the method of avoiding this was proposed which also allows to reduce collector loading in gyrotrons operating in modulated regimes. The present study also includes theoretical analysis of the processes that deepens the understanding of microwave breakdown (arcing) in high power microwave devices. The effect of the dust particles microprotrusions on the device operation was analyzed. These microprotrusions were observed and their negative effects were remedied by careful polishing and machining of the resonator surface. Finally, the generated 670 GHz radiation was

  19. Design Analysis of An Electromagnetic Band Gap Microstrip Antenna

    Directory of Open Access Journals (Sweden)

    M. S. Alam

    2011-01-01

    Full Text Available Problem statement: Wideband compact antenna is highly demandable due to the dynamic development in the wireless technology. Approach: A simple, compact EBG microstrip antenna is proposed in this study that covers a wideband of 250 GHz and the design is conformal with the 2.45 GHz ISM band (WLAN, IEEE 802.11b and g/Bluetooth/RFID applications. Results: A 6×6 array of square unit cell formed the EBG structure which is incorporated with the radiating patch to enhance the antenna performances. This design achieved an impedance bandwidth of 10.14% (2.34-2.59 GHz at -10 dB return loss and VSWR ≤ 2. Simulated radiation pattern is almost omnideirectional. Conclusion/Recommendations: The simulated results prove the compatibility of the EBG antenna with the 2.45 GHz ISM band applications. Further enhancement of the antenna performance with improved design is under consideration.

  20. A compact triple-band bandpass filter based on metamaterials

    Science.gov (United States)

    Zhao, Ya-juan; Jiang, Bo; Li, Bao-yi; Wang, Dong-hong

    2016-07-01

    This paper presents a compact triple-band bandpass filter based on metamaterials. The miniaturization is realized by the principle of phase compensation of metamaterial. Compared with the conventional half-wavelength filter, the metamaterial filter has a small size of 10 mm×10 mm. The triple-band bandpass filter performance has been validated by the electromagnetic simulation software of high frequency structure simulator (HFSS). The results illustrate that the filter is designed with center frequencies of 2.4 GHz, 5.1 GHz and 8.8 GHz, bandwidths of about 7.9% (2.31—2.50 GHz), 7.8% (5.0—5.4 GHz) and 7.4% (8.50—9.15 GHz), respectively, and it shows good band pass characteristics.

  1. Assessment of 28 nm UTBB FD-SOI technology platform for RF applications: Figures of merit and effect of parasitic elements

    Science.gov (United States)

    Kazemi Esfeh, B.; Kilchytska, V.; Barral, V.; Planes, N.; Haond, M.; Flandre, D.; Raskin, J.-P.

    2016-03-01

    This work provides a detailed study of 28 nm fully-depleted silicon-on-insulator (FD-SOI) planar ultra-thin body and BOX (UTBB) MOSFETs for high frequency applications. All parasitic elements such as the parasitic gate and source/drain series resistances, total capacitances are extracted and their effects on RF performance are analyzed and compared with previous work on similar devices. Two main RF figures of merit (FoM) such as the current gain cut-off frequency (fT) and the maximum oscillation frequency (fmax) are determined. It is shown that fT of ∼280 GHz and fmax of ∼250 GHz are achievable in the shortest devices. Based on the extracted parameters, the validation of the small-signal equivalent circuit used for modeling UTBB MOSFETs is investigated by comparing simulated and measured S-parameters.

  2. WSPEC: A Waveguide Filter Bank Spectrometer

    CERN Document Server

    Che, George; Underhill, Matthew; Mauskopf, Philip; Groppi, Christopher; Jones, Glenn; Johnson, Bradley; McCarrick, Heather; Flanigan, Daniel; Day, Peter

    2015-01-01

    We have designed, fabricated, and measured a 5-channel prototype spectrometer pixel operating in the WR10 band to demonstrate a novel moderate-resolution (R=f/{\\Delta}f~100), multi-pixel, broadband, spectrometer concept for mm and submm-wave astronomy. Our design implements a transmission line filter bank using waveguide resonant cavities as a series of narrow-band filters, each coupled to an aluminum kinetic inductance detector (KID). This technology has the potential to perform the next generation of spectroscopic observations needed to drastically improve our understanding of the epoch of reionization (EoR), star formation, and large-scale structure of the universe. We present our design concept, results from measurements on our prototype device, and the latest progress on our efforts to develop a 4-pixel demonstrator instrument operating in the 130-250 GHz band.

  3. Atmosphere characterization for simulation of the two optimal wireless terahertz digital communication links.

    Science.gov (United States)

    Mandehgar, Mahboubeh; Yang, Yihong; Grischkowsky, D

    2013-09-01

    Our studies of terahertz pulse propagation in the atmosphere have identified the two most optimal communication channels. The potential of these channels is demonstrated by physically accurate linear dispersion theory calculations of digital pulse propagation, showing it is possible to have two high-performance, point-to-point digital terahertz links in the atmosphere: a direct 95 GHz, 20 km ground link at 9.5 Gb/s with power loss of 10 dB due to water vapor at RH 58% (10 g/m3) and 20°C, and a direct 250 GHz, geosynchronous satellite link at 20.8 Gb/s with a 2 km zenith path with water vapor loss of 9 dB.

  4. Study on a terahertz modulator based on metamaterial with photoinduced vanadium dioxide film

    Science.gov (United States)

    Zhang, Hui; Jiang, Ping; Xu, Xian-feng

    2016-06-01

    Applying the photoexcitation characteristics of vanadium dioxide (VO2), a dynamic resonant terahertz (THz) modulation with the combination of a VO2 film and a metamaterial was suggested to realize THz wave active manipulation. The designed metamaterial with structured copper rings arrays can realize a passband from 0.776 to 1.045 THz. When insulator-metal phase transition in VO2 thin film, which is deposited on the other surface of the metamaterial substrate, is induced by optical pumping, the metamaterial/VO2 film hybrid structure behaves as an absorber with absorption rates of 90% at 0.88 THz and the transmission energy decrease to less than 3%. Therefore, about 78% modulation depth and more than 250 GHz modulation bandwidth have been reached under the photoinducing. The simulation results illustrate the promise of using phase transition materials for efficient broadband fast response modulators for THz waves.

  5. Terahertz multi-heterodyne spectroscopy using laser frequency combs

    CERN Document Server

    Yang, Yang; Hayton, Darren J; Gao, Jian-Rong; Reno, John L; Hu, Qing

    2016-01-01

    Frequency combs based on terahertz quantum cascade lasers feature broadband coverage and high output powers in a compact package, making them an attractive option for broadband spectroscopy. Here, we demonstrate the first multi-heterodyne spectroscopy using two terahertz quantum cascade laser combs. With just 100 $\\mu$s of integration time, we achieve peak signal-to-noise ratios exceeding 60 dB and a spectral coverage greater than 250 GHz centered at 2.8 THz. Even with room-temperature detectors we are able to achieve peak signal-to-noise ratios of 50 dB, and as a proof-of-principle we use these combs to measure the broadband transmission spectrum of etalon samples. Finally, we show that with proper signal processing, it is possible to extend the multi-heterodyne spectroscopy to quantum cascade laser combs operating in pulsed mode, greatly expanding the range of quantum cascade lasers that could be suitable for these techniques.

  6. Milli-tesla NMR and spectrophotometry of liquids hyperpolarized by dissolution dynamic nuclear polarization

    Science.gov (United States)

    Zhu, Yue; Chen, Chia-Hsiu; Wilson, Zechariah; Savukov, Igor; Hilty, Christian

    2016-09-01

    Hyperpolarization methods offer a unique means of improving low signal strength obtained in low-field NMR. Here, simultaneous measurements of NMR at a field of 0.7 mT and laser optical absorption from samples hyperpolarized by dissolution dynamic nuclear polarization (D-DNP) are reported. The NMR measurement field closely corresponds to a typical field encountered during sample injection in a D-DNP experiment. The optical spectroscopy allows determination of the concentration of the free radical required for DNP. Correlation of radical concentration to NMR measurement of spin polarization and spin-lattice relaxation time allows determination of relaxivity and can be used for optimization of the D-DNP process. Further, the observation of the nuclear Overhauser effect originating from hyperpolarized spins is demonstrated. Signals from 1H and 19F in a mixture of trifluoroethanol and water are detected in a single spectrum, while different atoms of the same type are distinguished by J-coupling patterns. The resulting signal changes of individual peaks are indicative of molecular contact, suggesting a new application area of hyperpolarized low-field NMR for the determination of intermolecular interactions.

  7. Seasonal population density and winter survival strategies of endangered Kashmir gray langur (Semnopithecus ajax) in Dachigam National Park, Kashmir, India.

    Science.gov (United States)

    Mir, Zaffar Rais; Noor, Athar; Habib, Bilal; Veeraswami, Gopi Govindan

    2015-01-01

    The population density of Kashmir gray langurs (Semnopithecus ajax) was studied in Dachigam National Park (DNP), Kashmir using distance sampling method. A total of 13 transects (1.5-2.5 km in length) were surveyed in the intensive study area (~90 km(2)) yielding 170 encounters in different seasons of the study period (2011-2013). Some aspects of behavior and feeding were also studied during the winter months (Dec-Feb) of 2012 and 2013 inside DNP. We used instantaneous scan sampling to collect behavioral data determining the time budget and diet of langurs in winter conditions. Results suggested that the density of Kashmir gray langurs varied marginally across seasons, with the highest density recorded during winter and lowest during summer season. Langurs spent most of their time in carrying out various social activities (34.32 %) and least in resting (18.41 %). Langurs fed upon 13 plant species (belonging to 12 families) and consumed a substantial proportion of bark (37.4 %) in their diet. We conclude that langur density is low in DNP as compared to other plain areas of the Indian subcontinent and langurs in DNP have balanced their time budget and diet so as to increase their chances of survival in the unfavorably cold and food scarce winter conditions.

  8. : a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules.

    Science.gov (United States)

    Jagtap, Anil P; Geiger, Michel-Andreas; Stöppler, Daniel; Orwick-Rydmark, Marcella; Oschkinat, Hartmut; Sigurdsson, Snorri Th

    2016-05-19

    Dynamic nuclear polarization (DNP) is an efficient method to overcome the inherent low sensitivity of magic-angle spinning (MAS) solid-state NMR. We report a new polarizing agent (), designed for biological applications, that yielded an enhancement value of 244 in a microcrystalline SH3 domain sample at 110 K. PMID:27161650

  9. Mentoring Nurses in Political Skill to Navigate Organizational Politics

    Science.gov (United States)

    2016-01-01

    Objective. The aim of this study was to describe and analyze the correlations between mentoring functions and political skill development among nurses who have earned or are candidates for a Ph.D. or doctorate of nursing practice (DNP) degree. Background. The healthcare system is in flux; future generations of Ph.D. and DNP nurse leaders will be required to demonstrate political acumen. Political skill to navigate organizational politics has had limited research within nursing. Methods. A cross-sectional research design using a web-based survey of 222 nurses who have earned or are candidates for a Ph.D. or DNP. This study utilized two validated tools to measure mentoring functions and political skill. Results. The response rate was 52% (n = 115) of which 86 were Ph.D. and 29 were DNPs. An informal mentoring relationship was described by 62% of the respondents and formal mentoring by 35% of the protégés; only 25% (n = 74) established a mentoring contract. Mentoring score showed significance for total political skill and moderate effect on the networking ability. The mentoring functions of advocacy, career development facilitation, learning facilitation, and friendship were found to correlate significantly with total political skill scores. Conclusions. This study established a benefit for nurses who have earned or are candidates for a Ph.D. or DNP from mentoring to support political skill development. PMID:27777798

  10. ¿Llegó el tiempo de la agricultura?

    Directory of Open Access Journals (Sweden)

    Machado C. Absalón

    1995-06-01

    Full Text Available El objetivo de este breve comentario es analizar los postuladosque se formulan en el Plan de Desarrollo El Salto Social, [Presidencia-DNP 1994] de modo que no se consideran otros documentos oficiales expedidos antes o después de la publicación del Plan.

  11. Cellular cooperation during in vivo anti-hapten antibody responses. I. The effect of cell number on the response

    International Nuclear Information System (INIS)

    Cellular interactions in adoptive secondary anti-hapten antibody responses to the hapten 2,4-dinitrophenyl (DNP) have been studied. It was shown that DNP-specific B cells must interact with carrier specific helper T cells to give optimal responses. Independent titration of B cell and helper cell activity in adoptive anti-DNP antibody responses gave the following results: Doubling the number of transferred B cells approximately doubled the subsequent antibody response. Doubling the number of helper cells leads to nearly 4 times as much anti-DNP antibody, measured 7 days after boosting (''premium effect''). This marked effect of helper cell number on the antibody response is thought to be due primarily to the interaction of two populations of carrier-specific cells in the helper effect, or to the interaction of two activities of a single population of helper cells, namely clone activation and clone expansion. Only a very small proportion of the premium effect given by helper cells could be attributed to increases in antibody affinity. (U.S.)

  12. A novel wireless Love wave biosensor platform for multifunctional detection

    Science.gov (United States)

    Song, Taehyeon; Nam, Minwoo; Song, SeungYeon; Yoon, Hyun C.; Lee, Keekeun

    2011-02-01

    This paper presents a novel wireless Love wave biosensor platform for multi-functional detection. A 440MHz wireless and surface acoustic wave (SAW)-based biosensor was developed on a 41° YX LiNbO3 piezoelectric substrate for the simultaneous detection of Anti- Dinitrophenyl-KLH (anti-DNP) immunoglobulin G (IgG). The developed biosensor was composed of a SAW reflective delay lines structured by an interdigital transducer (IDT), shorted grating reflectors, poly(methyl-methacrylate) (PMMA) layer and two sensitive films (Cr/Au). The PMMA was used for the waveguide layer. Coupling of mode (COM) modeling was conducted to determine the optimal device parameters prior to fabrication. The fabricated devices were wirelessly characterized by using the network analyzer as the reader unit. The binding of anti-DNP to DNP receptor molecules induced a change in phase shifts of the original reflection peaks due to a mass loading effect. The phase shifts increased linearly with increasing anti-DNP concentration. The measured reflective coefficient S11 in the time domain showed high signal/noise (S/N) ratio, small signal attenuation, and few spurious peaks. The time positions of the reflection peaks were well matched with the predicted values from the simulation. The obtained sensitivity was 167.9°/μg/ml and 44.8°/ μg/ml for the 1st and the 2nd sensing area, respectively.

  13. Recycling and imaging of nuclear singlet hyperpolarization

    DEFF Research Database (Denmark)

    Pileio, Giuseppe; Bowen, Sean; Laustsen, Christoffer;

    2013-01-01

    observation of the same batch of polarized nuclei over a period of 30 min and more. We report a recycling protocol in which the enhanced nuclear polarization achieved by dissolution-DNP is observed with full intensity and then returned to singlet order. MRI experiments may be run on a portion of the available...

  14. On The Potential of Dynamic Nuclear Polarization Enhanced Diamonds in Solid-State and Dissolution (13) C NMR Spectroscopy.

    Science.gov (United States)

    Bretschneider, Christian O; Akbey, Ümit; Aussenac, Fabien; Olsen, Greg L; Feintuch, Akiva; Oschkinat, Hartmut; Frydman, Lucio

    2016-09-01

    Dynamic nuclear polarization (DNP) is a versatile option to improve the sensitivity of NMR and MRI. This versatility has elicited interest for overcoming potential limitations of these techniques, including the achievement of solid-state polarization enhancement at ambient conditions, and the maximization of (13) C signal lifetimes for performing in vivo MRI scans. This study explores whether diamond's (13) C behavior in nano- and micro-particles could be used to achieve these ends. The characteristics of diamond's DNP enhancement were analyzed for different magnetic fields, grain sizes, and sample environments ranging from cryogenic to ambient temperatures, in both solution and solid-state experiments. It was found that (13) C NMR signals could be boosted by orders of magnitude in either low- or room-temperature solid-state DNP experiments by utilizing naturally occurring paramagnetic P1 substitutional nitrogen defects. We attribute this behavior to the unusually long electronic/nuclear spin-lattice relaxation times characteristic of diamond, coupled with a time-independent cross-effect-like polarization transfer mechanism facilitated by a matching of the nitrogen-related hyperfine coupling and the (13) C Zeeman splitting. The efficiency of this solid-state polarization process, however, is harder to exploit in dissolution DNP-enhanced MRI contexts. The prospects for utilizing polarized diamond approaching nanoscale dimensions for both solid and solution applications are briefly discussed.

  15. 76 FR 19375 - Safety and Efficacy of Hypnotic Drugs; Public Meeting

    Science.gov (United States)

    2011-04-07

    ... insomnia. The Division of Neurology Products (DNP) in FDA's Center for Drug Evaluation and Research and the Pharmaceutical Education and Research Institute (PERI) are cosponsoring the 2-day meeting, with the first day... Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 22, rm. 4342, Silver Spring,...

  16. Simultaneous Acquisition of Multi-nuclei Enhanced NMR/MRI by Solution State Dynamic Nuclear Polarization

    CERN Document Server

    He, Yugui; Feng, Jiwen; Huang, Chongyang; Chen, Fang; Liu, Maili; Liu, Chaoyang

    2015-01-01

    Dynamic nuclear polarization (DNP) has become a very important hyperpolarization method because it can dramatically increase the sensitivity of nuclear magnetic resonance (NMR) of various molecules. Liquid-state DNP based on Overhauser effect is capable of directly enhancing polarizations of all kinds of nuclei in the system. The combination of simultaneous Overhauser multi-nuclei enhancements with the multi-nuclei parallel acquisitions provides a variety of important applications in both MR spectroscopy (MRS) and image (MRI). Here we present two simple illustrative examples for simultaneously enhanced multi-nuclear spectra and images to demonstrate the principle and superiority. We have observed very large simultaneous DNP enhancements for different nuclei, such as 1H and 23Na, 1H and 31P, 19F and 31P, especially for the first time to report sodium ion enhancement in liquid. We have also obtained the simultaneous imaging of 19H and 31P at low field by solution-state DNP for the first time. This method can ob...

  17. 42 CFR 410.76 - Clinical nurse specialists' services.

    Science.gov (United States)

    2010-10-01

    ... Doctor of Nursing Practice (DNP) doctoral degree; and (3) Be certified as a clinical nurse specialist by... nurse specialist's services; (3) Although incidental, are an integral part of the professional service... immediately available). (e) Professional services. Clinical nurse specialists can be paid for...

  18. 76 FR 38206 - Notice of Application for Disclaimer of Interest; Pennington County, South Dakota

    Science.gov (United States)

    2011-06-29

    ... Montana State Office, 5001 Southgate Drive, Billings, MT 59101-4669. Only written comments will be... Office, 5001 Southgate Drive, Billings, MT 59101-4669; 406-896-5053. Persons who use a telecommunications... Resources. BILLING CODE 4310-DN-P...

  19. 75 FR 3489 - Notice of Public Meeting, Eastern Montana Resource Advisory Council Meeting

    Science.gov (United States)

    2010-01-21

    ... Montana Resource Advisory Council will be held on March 4, 2010, in Billings, MT. The meeting will start... in Montana. At these meetings, topics will include: Miles City and Billings Field Office manager..., 2010. M. Elaine Raper, District Manager. BILLING CODE 4310-DN-P...

  20. Doctor of Professional Counseling: The Next Step

    Science.gov (United States)

    Southern, Stephen; Cade, Rochelle; Locke, Don W.

    2012-01-01

    Professional doctorates have been established in the allied health professions by clinicians seeking the highest levels of independent practice. Allied health professional doctorates include nursing practice (DNP), occupational therapy (OTD), psychology (PsyD), social work (DSW), and marriage and family therapy (DMFT). Lessons learned from the…

  1. Electroanalytical determination of donepezil HCl in tablets and human serum by differential pulse and osteryoung square wave voltammetry at a glassy carbon electrode.

    Science.gov (United States)

    Golcu, A; Ozkan, S A

    2006-09-01

    Donepezil hydrochloride (DNP) is used for the treatment of mild to moderate dementia of the Alzheimer's type. The voltammetric behavior of DNP was studied at a glassy carbon electrode using cyclic, linear sweep, differential pulse (DPV) and square-wave (OSWV) voltammetric techniques. DNP exhibited irreversible anodic waves within the pH range 1.80 and 9.00 in different supporting electrolytes. The peak was characterized as being irreversible and diffusion-controlled. The possible mechanism of the oxidation process is discussed. The current-concentration plot was rectilinear over the range from 1 x 10(-6) to 1 x 10(-4) M in Britton-Robinson buffer at pH 7.0 with a correlation coefficient between 0.997 and 0.999 in supporting electrolyte and human serum samples using the DPV and SWV techniques. The repeatability and reproducibility of the methods for both media (supporting electrolyte and serum sample) were determined. Precision and accuracy of the developed methods were demonstrated by recovery studies. The standard addition method was used for the recovery studies. No electroactive interferences were found in biological fluids from endogenous substances or additives present in tablets. The methods developed were successfully applied to the determination of DNP in tablets and in spiked human serum.

  2. SUMMARY OF EXPERIMENTAL RESEARCH OF GASOLINE AND OIL FRACTIONS

    Directory of Open Access Journals (Sweden)

    Kharchenko P. M.

    2014-05-01

    Full Text Available In the article we present the results of pilot studies of petrol and oil fractions; their main physical and chemical properties, density and DNP, a liquid phase, two-phase area, critical area and boundary curves are considered

  3. Influence of PUVA and UVB radiation on delayed hypersensitivity in the guinea pig

    International Nuclear Information System (INIS)

    Exposure of guinea pigs to UVA (320--400 nm) radiation following administration of 8-methoxypsoralen by gavage (referred to by the acronym, PUVA) or exposure to UVB (290--320 nm) radiation, produced suppression of the cutaneous delayed hypersensitivity reaction at the site of exposure to radiation and at distant nonexposed sites. In these experiments, the animals were immunized by injection of dinitrophenyl-bovine gamma-globulin (DNP-BGG) in complete Freund's adjuvant and delayed hypersensitivity responses were provoked by intradermal injections of DNP-BGG, DNP and BGG on the flanks. Exposure to erythemogenic doses of either PUVA or UVB radiation for 7 days prior to immunization and for the 7 days between immunization and challenge (total period of radiation: 14 days) produced inhibiton of responses to each of the test substances. In addition, treatment with erythemogenic doses of PUVA either for 7 days prior to immunization or during the interval between immunization and challenge with DNP-BGG, inhibited the delayed hypersensitivity responses at the site of irradiation and at a nonexposed site. These findings suggest that in vivo exposure to nonionizing radiation leads to both local and systemic alteration of certain immune responses

  4. Photocatalytic degradation of 2,4-dinitrophenol

    International Nuclear Information System (INIS)

    Contamination of the food supply from agricultural waste is an increasing concern worldwide. Numerous hazardous chemicals enter the environment from various industrial sources daily. Many of these pollutants, including 2,4-dinitrophenol (2,4-DNP), are water soluble, toxic, and not easily biodegradable. The solar photocatalytic degradation of 2,4-DNP was investigated in a solution of titanium dioxide (TiO2) that was prepared to be an optically clear aqueous solution of nanosized particles of TiO2. In order to achieve optimal efficiency of the photodegradation, the effects of light intensity and pH were conducted. All experiments were carried out in a batch mode. At a pH of 8, maximum removal of 70% of 2,4-DNP was achieved within 7 h of irradiation time. The nearly homogeneous solution of 5.8 nm TiO2 particles, size determined by XDS, were very effective in the photocatalytic degradation of 2,4-DNP

  5. Theoretical aspects of Magic Angle Spinning - Dynamic Nuclear Polarization.

    Science.gov (United States)

    Mentink-Vigier, Frederic; Akbey, Ümit; Oschkinat, Hartmut; Vega, Shimon; Feintuch, Akiva

    2015-09-01

    Magic Angle Spinning (MAS) combined with Dynamic Nuclear Polarization (DNP) has been proven in recent years to be a very powerful method for increasing solid-state NMR signals. Since the advent of biradicals such as TOTAPOL to increase the nuclear polarization new classes of radicals, with larger molecular weight and/or different spin properties have been developed. These have led to unprecedented signal gain, with varying results for different experimental parameters, in particular the microwave irradiation strength, the static field, and the spinning frequency. Recently it has been demonstrated that sample spinning imposes DNP enhancement processes that differ from the active DNP mechanism in static samples as upon sample spinning the DNP enhancements are the results of energy level anticrossings occurring periodically during each rotor cycle. In this work we present experimental results with regards to the MAS frequency dependence of the DNP enhancement profiles of four nitroxide-based radicals at two different sets of temperature, 110 and 160K. In fact, different magnitudes of reduction in enhancement are observed with increasing spinning frequency. Our simulation code for calculating MAS-DNP powder enhancements of small model spin systems has been improved to extend our studies of the influence of the interaction and relaxation parameters on powder enhancements. To achieve a better understanding we simulated the spin dynamics of a single three-spin system {ea-eb-n} during its steady state rotor periods and used the Landau-Zener formula to characterize the influence of the different anti-crossings on the polarizations of the system and their necessary action for reaching steady state conditions together with spin relaxation processes. Based on these model calculations we demonstrate that the maximum steady state nuclear polarization cannot become larger than the maximum polarization difference between the two electrons during the steady state rotor cycle. This

  6. A peripheral component interconnect express-based scalable and highly integrated pulsed spectrometer for solution state dynamic nuclear polarization

    International Nuclear Information System (INIS)

    High sensitivity, high data rates, fast pulses, and accurate synchronization all represent challenges for modern nuclear magnetic resonance spectrometers, which make any expansion or adaptation of these devices to new techniques and experiments difficult. Here, we present a Peripheral Component Interconnect Express (PCIe)-based highly integrated distributed digital architecture pulsed spectrometer that is implemented with electron and nucleus double resonances and is scalable specifically for broad dynamic nuclear polarization (DNP) enhancement applications, including DNP-magnetic resonance spectroscopy/imaging (DNP-MRS/MRI). The distributed modularized architecture can implement more transceiver channels flexibly to meet a variety of MRS/MRI instrumentation needs. The proposed PCIe bus with high data rates can significantly improve data transmission efficiency and communication reliability and allow precise control of pulse sequences. An external high speed double data rate memory chip is used to store acquired data and pulse sequence elements, which greatly accelerates the execution of the pulse sequence, reduces the TR (time of repetition) interval, and improves the accuracy of TR in imaging sequences. Using clock phase-shift technology, we can produce digital pulses accurately with high timing resolution of 1 ns and narrow widths of 4 ns to control the microwave pulses required by pulsed DNP and ensure overall system synchronization. The proposed spectrometer is proved to be both feasible and reliable by observation of a maximum signal enhancement factor of approximately −170 for 1H, and a high quality water image was successfully obtained by DNP-enhanced spin-echo 1H MRI at 0.35 T

  7. A continuous fluorescent assay for the determination of plasma and tissue angiotensin I-converting enzyme activity

    Directory of Open Access Journals (Sweden)

    M.F. Alves

    2005-06-01

    Full Text Available A continuous assay using internally quenched fluorescent peptides with the general sequence Abz-peptidyl-(DnpP-OH (Abz = ortho-aminobenzoic acid; Dnp = 2,4-dinitrophenyl was optimized for the measurement of angiotensin I-converting enzyme (ACE in human plasma and rat tissues. Abz-FRK(DnpP-OH, which was cleaved at the Arg-Lys bond by ACE, was used for the enzyme evaluation in human plasma. Enzymatic activity was monitored by continuous recording of the fluorescence (lambdaex = 320 nm and lambdaem = 420 nm at 37ºC, in 0.1 M Tris-HCl buffer, pH 7.0, with 50 mM NaCl and 10 µM ZnCl2. The assays can be performed directly in the cuvette of the fluorimeter and the hydrolysis followed for 5 to 10 min. ACE measurements in the plasma of 80 healthy patients with Hip-His-Leu and with Abz-FRK(DnpP-OH correlated closely (r = 0.90, P < 0.001. The specificity of the assay was demonstrated by the complete inhibition of hydrolysis by 0.5 µM lisinopril or captopril. Abz-FRK(DnpP-OH cleavage by ACE was monitored in rat lung, kidney, heart, and liver homogenates in the presence of a cocktail of inhibitors containing trans-epoxy-succinyl-L-leucylamido-(4-guanido-butene, pepstatin, phenyl-methylsulfonyl fluoride, N-tosyl-L-phenylalanyl-chloromethyl ketone, and N-tosyl-lysyl-chloromethyl ketone to prevent undesirable hydrolysis. ACE activity in lung, heart and kidney homogenates, but not in liver homogenates, was completely abolished by 0.5 µM lisinopril or captopril. The advantages of the method are the procedural simplicity and the high sensitivity providing a rapid assay for ACE determinations.

  8. Novel design for centrifugal counter-current chromatography: VI. Ellipsoid column.

    Science.gov (United States)

    Gu, Dongyu; Yang, Yi; Xin, Xuelei; Aisa, Haji Akber; Ito, Yoichiro

    2015-01-01

    A novel ellipsoid column was designed for centrifugal counter-current chromatography. Performance of the ellipsoid column with a capacity of 3.4 mL was examined with three different solvent systems composed of 1-butanol-acetic acid-water (4:1:5, v/v) (BAW), hexane-ethyl acetate-methanol-0.1 M HCl (1:1:1:1, v/v) (HEMH), and 12.5% (w/w) PEG1000 and 12.5% (w/w) dibasic potassium phosphate in water (PEG-DPP) each with suitable test samples. In dipeptide separation with BAW system, both stationary phase retention (Sf) and peak resolution (Rs) of the ellipsoid column were much higher at 0° column angle (column axis parallel to the centrifugal force) than at 90° column angle (column axis perpendicular to the centrifugal force), where elution with the lower phase at a low flow rate produced the best separation yielding Rs at 2.02 with 27.8% Sf at a flow rate of 0.07 ml/min. In the DNP-amino acid separation with HEMW system, the best results were obtained at a flow rate of 0.05 ml/min with 31.6% Sf yielding high Rs values at 2.16 between DNP-DL-glu and DNP-β-ala peaks and 1.81 between DNP-β-ala and DNP-L-ala peaks. In protein separation with PEG-DPP system, lysozyme and myolobin were resolved at Rs of 1.08 at a flow rate of 0.03 ml/min with 38.9% Sf. Most of those Rs values exceed those obtained from the figure-8 column under similar experimental conditions previously reported.

  9. A peripheral component interconnect express-based scalable and highly integrated pulsed spectrometer for solution state dynamic nuclear polarization

    Energy Technology Data Exchange (ETDEWEB)

    He, Yugui; Liu, Chaoyang, E-mail: chyliu@wipm.ac.cn [Wuhan National Laboratory for Optoelectronics, School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074 (China); State Key Laboratory of Magnet Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071 (China); Feng, Jiwen; Wang, Dong; Chen, Fang; Liu, Maili [State Key Laboratory of Magnet Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071 (China); Zhang, Zhi; Wang, Chao [State Key Laboratory of Magnet Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071 (China); University of Chinese Academy of Sciences, Beijing 100048 (China)

    2015-08-15

    High sensitivity, high data rates, fast pulses, and accurate synchronization all represent challenges for modern nuclear magnetic resonance spectrometers, which make any expansion or adaptation of these devices to new techniques and experiments difficult. Here, we present a Peripheral Component Interconnect Express (PCIe)-based highly integrated distributed digital architecture pulsed spectrometer that is implemented with electron and nucleus double resonances and is scalable specifically for broad dynamic nuclear polarization (DNP) enhancement applications, including DNP-magnetic resonance spectroscopy/imaging (DNP-MRS/MRI). The distributed modularized architecture can implement more transceiver channels flexibly to meet a variety of MRS/MRI instrumentation needs. The proposed PCIe bus with high data rates can significantly improve data transmission efficiency and communication reliability and allow precise control of pulse sequences. An external high speed double data rate memory chip is used to store acquired data and pulse sequence elements, which greatly accelerates the execution of the pulse sequence, reduces the TR (time of repetition) interval, and improves the accuracy of TR in imaging sequences. Using clock phase-shift technology, we can produce digital pulses accurately with high timing resolution of 1 ns and narrow widths of 4 ns to control the microwave pulses required by pulsed DNP and ensure overall system synchronization. The proposed spectrometer is proved to be both feasible and reliable by observation of a maximum signal enhancement factor of approximately −170 for {sup 1}H, and a high quality water image was successfully obtained by DNP-enhanced spin-echo {sup 1}H MRI at 0.35 T.

  10. Programmed Cell Death Induced by (−)-8,9-Dehydroneopeltolide in Human Promyelocytic Leukemia HL-60 Cells under Energy Stress Conditions

    Science.gov (United States)

    Fuwa, Haruhiko; Sato, Mizuho; Sasaki, Makoto

    2014-01-01

    (+)-Neopeltolide is a marine macrolide natural product that exhibits potent antiproliferative activity against several human cancer cell lines. Previous study has established that this natural product primarily targets the complex III of the mitochondrial electron transport chain. However, the biochemical mode-of-actions of neopeltolide have not been investigated in detail. Here we report that (−)-8,9-dehydroneopeltolide (8,9-DNP), a more accessible synthetic analogue, shows potent cytotoxicity against human promyelocytic leukemia HL-60 cells preferentially under energy stress conditions. Nuclear morphology analysis, as well as DNA ladder assay, indicated that 8,9-DNP induced significant nuclear condensation/fragmentation and DNA fragmentation, and these events could be suppressed by preincubating the cells with a pan-caspase inhibitor, N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (zVAD). Immunoblot analysis demonstrated the release of cytochrome c from the mitochondria and the cleavage of full-length caspase-3 and poly(ADP-ribose) polymerase (PARP). These results indicated that 8,9-DNP induced caspase-dependent apoptotic programmed cell death under energy stress conditions. It was also found that 8,9-DNP induced non-apoptotic cell death in the presence/absence of zVAD under energy stress conditions. Immunoblot analysis showed the intracytosolic release of apoptosis-inducing factor (AIF), although it did not further translocate to the nucleus. It appears most likely that, in the presence of zVAD, 8,9-DNP triggered necrotic cell death as a result of severe intracellular ATP depletion. PMID:25419998

  11. Programmed Cell Death Induced by (−-8,9-Dehydroneopeltolide in Human Promyelocytic Leukemia HL-60 Cells under Energy Stress Conditions

    Directory of Open Access Journals (Sweden)

    Haruhiko Fuwa

    2014-11-01

    Full Text Available (+-Neopeltolide is a marine macrolide natural product that exhibits potent antiproliferative activity against several human cancer cell lines. Previous study has established that this natural product primarily targets the complex III of the mitochondrial electron transport chain. However, the biochemical mode-of-actions of neopeltolide have not been investigated in detail. Here we report that (−-8,9-dehydroneopeltolide (8,9-DNP, a more accessible synthetic analogue, shows potent cytotoxicity against human promyelocytic leukemia HL-60 cells preferentially under energy stress conditions. Nuclear morphology analysis, as well as DNA ladder assay, indicated that 8,9-DNP induced significant nuclear condensation/fragmentation and DNA fragmentation, and these events could be suppressed by preincubating the cells with a pan-caspase inhibitor, N-benzyloxycarbonyl-Val-Ala-Asp(OMe-fluoromethylketone (zVAD. Immunoblot analysis demonstrated the release of cytochrome c from the mitochondria and the cleavage of full-length caspase-3 and poly(ADP-ribose polymerase (PARP. These results indicated that 8,9-DNP induced caspase-dependent apoptotic programmed cell death under energy stress conditions. It was also found that 8,9-DNP induced non-apoptotic cell death in the presence/absence of zVAD under energy stress conditions. Immunoblot analysis showed the intracytosolic release of apoptosis-inducing factor (AIF, although it did not further translocate to the nucleus. It appears most likely that, in the presence of zVAD, 8,9-DNP triggered necrotic cell death as a result of severe intracellular ATP depletion.

  12. Overhauser effects in insulating solids

    Energy Technology Data Exchange (ETDEWEB)

    Can, T. V.; Corzilius, B.; Walish, J. J.; Griffin, R. G. [Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Caporini, M. A.; Rosay, M.; Maas, W. E. [Bruker BioSpin, Billerica, Massachusetts 01821 (United States); Mentink-Vigier, F.; Vega, S. [Weizmann Institute of Science, Rehovot (Israel); Baldus, M. [NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, 3584 CH Utrecht (Netherlands); Swager, T. M. [Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)

    2014-08-14

    We report magic angle spinning, dynamic nuclear polarization (DNP) experiments at magnetic fields of 9.4 T, 14.1 T, and 18.8 T using the narrow line polarizing agents 1,3-bisdiphenylene-2-phenylallyl (BDPA) dispersed in polystyrene, and sulfonated-BDPA (SA-BDPA) and trityl OX063 in glassy glycerol/water matrices. The {sup 1}H DNP enhancement field profiles of the BDPA radicals exhibit a significant DNP Overhauser effect (OE) as well as a solid effect (SE) despite the fact that these samples are insulating solids. In contrast, trityl exhibits only a SE enhancement. Data suggest that the appearance of the OE is due to rather strong electron-nuclear hyperfine couplings present in BDPA and SA-BDPA, which are absent in trityl and perdeuterated BDPA (d{sub 21}-BDPA). In addition, and in contrast to other DNP mechanisms such as the solid effect or cross effect, the experimental data suggest that the OE in non-conducting solids scales favorably with magnetic field, increasing in magnitude in going from 5 T, to 9.4 T, to 14.1 T, and to 18.8 T. Simulations using a model two spin system consisting of an electron hyperfine coupled to a {sup 1}H reproduce the essential features of the field profiles and indicate that the OE in these samples originates from the zero and double quantum cross relaxation induced by fluctuating hyperfine interactions between the intramolecular delocalized unpaired electrons and their neighboring nuclei, and that the size of these hyperfine couplings is crucial to the magnitude of the enhancements. Microwave power dependent studies show that the OE saturates at considerably lower power levels than the solid effect in the same samples. Our results provide new insights into the mechanism of the Overhauser effect, and also provide a new approach to perform DNP experiments in chemical, biophysical, and physical systems at high magnetic fields.

  13. Research and Development of 2-frequency (110/138 GHz FADIS for JT-60SA ECHCD system

    Directory of Open Access Journals (Sweden)

    Idei H.

    2015-01-01

    Full Text Available A FAst DIrectional Switch (FADIS of 2-frequency (2-ƒ gyrotron system for the JT-60SA project is being developed under collaboration between Japan Atomic Energy Agency (JAEA and Kyushu University. At first, the frequency drift and dip in the gyrotron operation were measured to consider which kind of FADIS is preferred for application in the Electron Cyclotron Heating and Current Drive (ECHCD system for the JT- 60SA. Various types of the FADIS have been considered. A square corrugated waveguide diplexer system with double resonant rings was considered as one of the most attractive FADIS systems for stable high-power and long-pulse operations in the 2-ƒ JT-60SA ECHCD system.

  14. Final report for the tunable driver for the LLNL FEL experiment

    International Nuclear Information System (INIS)

    This section of the report covers the recent operation of the prototype backward-wave oscillator (BWO) gyrotron. The tube was mounted in its fixture on the superconducting magnet, the beam aligned, and microwaves generated. Initial alignment and operation was performed at low wiggler magnet strength (Bw = 9 G) and thus low α = υ perpendicular/υ parallel. The microwaves observed under these conditions were at a frequency just above the electron cyclotron frequency of the interaction region. Identification of these waves is tentatively that of forward waves generated in what is a very long gyrotron cavity. By increasing the wiggler field to ∼ 18 G, the backward wave could then be observed. Voltage tunability of the backward wave was demonstrated and frequencies from 13 GHz to 143 GHz were observed

  15. Initial operation of ECRH heating experiments on the Versator II tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Luckhardt, S.C.; Chen, K.I.; Kirkwood, R.; Porkolab, M.; Singleton, D.; Squire, J.; Villasenor, J.; Lu, Z.

    1987-09-01

    Operation of a 35GHz electron cyclotron heating experiment has begun on Versator II with gyrotron power of 100kW. The EC antenna is located on the high magnetic field side of the plasma and launches linearly polarized radiation in the HE11 hybrid mode with externally controllable polarization and parallel index of refraction. The transmission system provides mode conversion from the TE01 output mode of the gyrotron to the HE11 mode and polarization control. The mode transformation characteristics of the transmission system were measured by means of a computer controlled two dimensional scanning system, and contour plots of the far field radiation pattern of each transmission system element were made and compared with theory. Overall the transmission system is found to be approximately 95% efficient with mode patterns in generally excellent agreement with theory.

  16. Experimental study on resonance relativistic SHF generators on the base of linear induction electron accelerator

    International Nuclear Information System (INIS)

    The results of studies on relativistic SHF-generators - orotron and gyrotron for obtaining data on the quality of a high-current electron beam shaped in the section of a linear induction accelerator are given. Axisymmetric resonators as sections of weak-irregular waveguides were used in both generators. Stable generation of short-wave radiation of 15-20 MW at the efficiency of 5-7% SHF pulse duration of 50 ns was obtained in the orotron at the wave length of 8.5 mm and current of 600 A. Stable generation of 7-10 MW SHF-radiation at the efficiency of 3-5% and pulse duration of 150 ns was observed in the gyrotron at the wave length of 12 mm. Under further acceleration in the following sections of the accelerator the electron beam may be used for obtaining radiation of shorter waves

  17. Infrared and millimeter waves. Volume 13 - Millimeter components and techniques. Part 4

    Science.gov (United States)

    Button, K. J.

    Recent experimentation and theoretical modeling of IR and millimeter-wave devices for various applications are discussed in depth. Attention is given to powerful gyrotrons for thermonuclear research, new, high power coherent, millimeter radiation sources, and a kinetic theory of a harmonic gyrotron oscillator with a slotted resonant structure. Communication, radar and radiometer applications of integrated fin-line components are discussed, and investigations into propagation and mode coupling phenomena in corrugated and smooth-wall circular waveguides are reviewed. The known far-infrared (FIR) properties of inhomogeneous materials are described, including experimentation with normal-metal and insulator composites and with superconductivity. Finally, recent experimental and theoretical work on solid-state spectroscopy with FIR continuous-wave lasers is summarized in comparison with the performance bounds of Fourier spectroscopy.

  18. Injection locking of an electronic maser in the hard excitation mode

    Energy Technology Data Exchange (ETDEWEB)

    Yakunina, K. A. [Saratov State University, 83 Astrakhanskaya St., 410012 Saratov (Russian Federation); Kuznetsov, A. P.; Ryskin, N. M. [Saratov State University, 83 Astrakhanskaya St., 410012 Saratov (Russian Federation); Department of Nonlinear Physics, Saratov Branch, V.A. Kotel' nikov Institute of Radio Engineering and Electronics, 38 Zelenaya St., 410019 Saratov (Russian Federation)

    2015-11-15

    The phenomenon of hard excitation is natural for many electronic oscillators. In particular, in a gyrotron, a maximal efficiency is often attained in the hard excitation regime. In this paper, we study the injection-locking phenomena using two models of an electronic maser in the hard excitation mode. First, bifurcation analysis is performed for the quasilinear model described by ordinary differential equations for the slow amplitude and phase. Two main scenarios of transition to the injection-locked mode are described, which are generalizations of the well-known phase-locking and suppression mechanisms. The results obtained for the quasilinear model are confirmed by numerical simulations of a gyrotron with fixed Gaussian structure of the RF field.

  19. Development of a Propagating Millimeter-Wave Beam Position and Profile Monitor in the Oversize Corrugated Waveguide Used in an ECRH System

    Science.gov (United States)

    Shimozuma, Takashi; Kobayashi, Sakuji; Ito, Satoshi; Ito, Yasuhiko; Kubo, Shin; Yoshimura, Yasuo; Nishiura, Masaki; Igami, Hiroe; Takahashi, Hiromi; Mizuno, Yoshinori; Okada, Kohta; Mutoh, Takashi

    2016-01-01

    In a high-power electron cyclotron resonance heating (ECRH) system for plasma heating, a long-distance and low-loss transmission system of the millimeter wave is required. A real-time monitor of the millimeter-wave beam position and its intensity profile, which can be used in a high-power, evacuated, and cooled transmission line, is proposed, designed, manufactured, and tested. The beam-position and profile monitor (BPM) consists of a reflector, Peltier-device array, and a heat-sink, which is installed in the reflector-plate of a miterbend. The BPM was tested using both simulated electric heater power and high-power gyrotron output power. The profile obtained from the monitor using the gyrotron output was well agreed with the burn patter on a thermal sensitive paper. Methods of data analysis and mode-content analysis of a propagating millimeter-wave in the corrugated waveguide are proposed.

  20. High-Power Microwave Transmission and Mode Conversion Program

    Energy Technology Data Exchange (ETDEWEB)

    Vernon, Ronald J. [Univ. of Wisconsin, Madison, WI (United States)

    2015-08-14

    This is a final technical report for a long term project to develop improved designs and design tools for the microwave hardware and components associated with the DOE Plasma Fusion Program. We have developed basic theory, software, fabrication techniques, and low-power measurement techniques for the design of microwave hardware associated gyrotrons, microwave mode converters and high-power microwave transmission lines. Specifically, in this report we discuss our work on designing quasi-optical mode converters for single and multiple frequencies, a new method for the analysis of perturbed-wall waveguide mode converters, perturbed-wall launcher design for TE0n mode gyrotrons, quasi-optical traveling-wave resonator design for high-power testing of microwave components, and possible improvements to the HSX microwave transmission line.

  1. Synthesis method for using in the design of an electron gun for gyrotion

    International Nuclear Information System (INIS)

    In this work a synthesis method is applied to the design of an electron gun for a 94GHz gyrotron. Using the synthesis method, it is found the shape of the electrodes compatible with the laminar flow which minimizes the action of space change on the electron velocity dispersion. A sistematic procedure is presented to fuid the parameters of the synthesis method which, in turn, are closely related to the characteristics of the aptoclechonic system. (author)

  2. Initial results of electron cyclotron range of frequency (ECRF) operation and experiments in JT-60U

    International Nuclear Information System (INIS)

    The 110 GHz 1 MW electron cyclotron range of frequency (ECRF) system was designed and constructed on JT-60U to locally heat and control the plasmas. The gyrotron has a diamond window to transmit RF power with Gaussian mode, which is easily transformed to HE11 mode for the transmission line of the corrugated waveguide. The second diamond window is installed at the inlet of the antenna for a vacuum seal between the transmission line and the JT-60U tokamak. The total length of the transmission line from the gyrotron to the antenna is about 60 m including nine meter bends, The antenna has a focusing mirror and a flat steerable one to focus and to control the RF beam angle mainly in the poloidal direction. In the initial operation, the power of PEC∼0.75 MW for 2 s was successfully injected into plasma when the gyrotron generated the power up to 1 MW. The total transmission efficiency from the gyrotron to the plasma was about 75%. A controllability of local electron heating with the deposition width of =15 cm was well demonstrated by using the steerable mirror. A large downshift in the deposition position was observed at the high Te plasma. Strong central electron heating was obtained from 2.2 to 6.6 keV for PEC∼0.75 MW, 0.3 s at the optimized polarization. An effective electron heating was also obtained up to ∼10 keV during EC injection for ∼1.6 s in the high βp H-mode plasma produced by NBI

  3. Characteristics of a Teflon rod antenna for millimeter and submillimeter wave irradiation on living bodies

    OpenAIRE

    TATSUKAWA, Toshiaki; Doi, Akitaka; TERANAKA, Masato; Takashima, Hitoshi; Goda, Fuminori; Idehara, Toshitaka; Ogawa, Isamu; KANEMAKI, Tomohiro; NISHIZAWA, Seiji; NAMBA, Tunetoyo

    2003-01-01

    The development of a millimeter and submillimeter wave catheter for irradiation on living bodies using a Teflon rod dielectric antenna is described. The power sources of electromagnetic wave are an Impatt oscillator (90 GHz, 0.3 W) and gyrotron (302 GHz, 30 W). Irradiation tests using various Teflon rod dielectric antennas were performed on beef livers. Irradiation results were considered by microwave theory and ray optics.

  4. テフロンフレキシブル導波管によるジャイロトロンFUCW-Ⅰの出力測定

    OpenAIRE

    寺中, 正人; 土井, 昭孚; 立川, 敏明; 光藤, 誠太郎; 斉藤, 輝雄; 出原, 敏孝; 難波, 経豊

    2007-01-01

    In order to develop the millimeter and sub-millimeter wave catheter irradiation apparatus for the living body, the output power by the catheter transmission using Gyrotron FUCW-Ⅰ(GYCOM, Russia) was measured at 300 GHz.The output power was measured by water loading. That was transferred by some flexible Teflon rod waveguides and that was decreased according to Teflon rod length. And we measured the power using dielectric Anti-Reflecting (AR) antennas too.

  5. Wills Plasma Physics Department annual progress report 1984

    International Nuclear Information System (INIS)

    The experimental program continued to be centred around work on the research tokamak TORTUS. Projects included the guiding of Alfven waves along helical magnetic field lines, the excitation of Alfven waves by an antenna and antenna designs for Alfven wave heating. Supporting work included studies of surface waves using the linear SUPPER IV machine, development of lasers and laser diagnostics, development of a neutral particle analyser for measuring ion temperatures, and development of a continuously tunable gyrotron

  6. Free-space power transmission

    Energy Technology Data Exchange (ETDEWEB)

    1989-11-01

    NASA Lewis Research Center organized a workshop on technology availability for free-space power transmission (beam power). This document contains a collection of viewgraph presentations that describes the effort by academia, industry, and the national laboratories in the area of high-frequency, high-power technology applicable to free-space power transmission systems. The areas covered were rectenna technology, high-frequency, high-power generation (gyrotrons, solar pumped lasers, and free electron lasers), and antenna technology.

  7. Preliminary conceptual design of DEMO EC system

    Energy Technology Data Exchange (ETDEWEB)

    Garavaglia, S., E-mail: garavaglia@ifp.cnr.it; Bin, W.; Bruschi, A.; Granucci, G.; Moro, A.; Rispoli, N. [Institute of Plasma Physics “P.Caldirola”, National Research Council of Italy, Milan (Italy); Grossetti, G.; Strauss, D. [IAM-AWP, Kaiserstr. 12, D-76131 Karlsruhe (Germany); Jelonnek, J. [IHM, KIT, Kaiserstr. 12, D-76131 Karlsruhe (Germany); Tran, Q. M. [CRPP, EPFL, EURATOM Association, CH-1015 Lausanne (Switzerland); Franke, T. [EUROfusion Consortium, Boltzmannstr. 2, D-85748 Garching (Germany); Max-Planck-Institut für Plasmaphysik, Garching (Germany)

    2015-12-10

    In the framework of EUROfusion Consortium the Work Package Heating and Current Drive addresses the engineering design and R&D for the electron cyclotron, ion cyclotron and neutral beam systems. This paper reports the activities performed in 2014, focusing on the work done regarding the input for the conceptual design of the EC system, particularly for the gyrotron, the transmission line and the launchers.

  8. Mode competition in fourth-harmonic magnicon amplifiers

    International Nuclear Information System (INIS)

    The magnicon is under development as an efficient high-power microwave amplifier for powering the next generation of electron accelerators for high-energy physics research. In the magnicon RF amplifier, the drive and gain cavities are cylindrical deflection cavities which operate in a rotating TM110-mode and spin up an electron beam to high transverse momentum. As a result of the rotating-mode interaction, the electron beam entry point into the output cavity rotates about the axis at the drive frequency. The gyrotron-like output cavity can be operated at m times the drive frequency by using a mode with an azimuthal index of m, as this mode rotates at m-1 times its RF frequency, thus maintaining synchronism with the electron beam. Previous frequency-multiplying magnicons have used m = 2; in this paper it is shown that magnicons with m = 4 may be practical, provided one also operates the output cavity at the m/2 harmonic of the cyclotron frequency. Operation at higher harmonics lowers the frequency of the deflection cavities allowing lower RF fields, reducing magnet cost and complexity; and a larger electron beam, relaxing beam quality constraints. On the other hand, higher order azimuthal-index magnicon modes interacting at higher order cyclotron interactions are subject to competition with nonsynchronous (gyrotron) modes and are more sensitive to electron beam scanning angle spread. A time-dependent multimode gyrotron code has been modified to examine competition in the output cavity between the phase-synchronous operating mode and other nonsynchronous modes which interact via the conventional gyrotron interaction

  9. Structure Design and Analysis of High-Voltage Power Supply for ECRH

    Institute of Scientific and Technical Information of China (English)

    WANG Lei; HUANG Yiyun; ZHAO Yanping; ZHANG Jian; YANG Lei; GUO Wenjun

    2014-01-01

    In order to develop a high-voltage power supply (HVPS) with high quality parameters,not only its electrical circuit but also its structure should be studied in detail.In this paper,the structure design of the collector power supply for gyrotron is discussed first.Then the electrical field and potential simulations of its main devices are analyzed.Finally,relevant calculations and conclusions are given.

  10. Fusion development and technology

    International Nuclear Information System (INIS)

    This report discusses the following: superconducting magnet technology; high field superconductors; advanced magnetic system and divertor development; poloidal field coils; gyrotron development; commercial reactor studies--aries; ITER physics: alpha physics and alcator R ampersand D for ITER; lower hybrid current drive and heating in the ITER device; ITER superconducting PF scenario and magnet analysis; ITER systems studies; and safety, environmental and economic factors in fusion development

  11. High-power microwave transmission systems for electron-cyclotron-resonance plasma heating

    Energy Technology Data Exchange (ETDEWEB)

    Vernon, R.J.

    1991-08-01

    This progress report is for the sixth year of a grant from the US Department of Energy for the design, development, and fabrication of ECRH transmission and mode conversion systems to transport microwave power from a gyrotron to a magnetically confined plasma. The design and low-power testing of new and improved components for such systems and development of underlying theory is the focus of this project. Devising and improving component testing and diagnostic techniques is also an important part of this effort. The development of possible designs for sections of gyrotrons themselves, such as tapers or Vlasov-type launchers, in support of the Varian gyrotron development program is also considered when appropriate. We also provide support to other groups working on ECR heating of magnetically confined plasmas such as the groups at General Atomics, the University of Texas at Austin, and Lawrence Livermore National Laboratory. During the last year, we designed and had fabricated a two-dimensional Vlasov antenna system for a 110 GHz TE{sub 15,2} mode gyrotron for possible use at General Atomics. The system included the launcher section, a visor, main reflector, and focusing reflector. Programs to generate the tool-path profiles to cut the General Atomics'' Vlasov components on a milling machine were developed. We have also developed state-of-the art theory and programs for three-dimensional whispering-gallery-mode Vlasov antenna systems. A design for a 110 GHz TE{sub 01}-TE{sub 15,2} mode converter system for cold testing WGM Vlasov antenna systems was developed and is currently being fabricated also.

  12. 3,4-二硝基吡唑的热行为及其与某些炸药组分的相容性%Thermal Behaviors of 3,4-Dinitrophyrazole and its Compatibility with Some Explosive Component Materials

    Institute of Scientific and Technical Information of China (English)

    蒋秋黎; 王浩; 罗一鸣; 王玮; 谢中元; 高杰

    2013-01-01

    用差示扫描量热(DSC)和热重/微分热重(TG/DTG),研究了3,4-二硝基吡唑(DNP)的热行为.用DSC法和真空安定性(VST)考察了DNP与炸药组分材料,包括2,4-二硝基苯甲醚(DNAN)、1,3,3-三硝基氮杂环丁烷(TNAZ)、黑索今(RDX)、奥克托今(HMX)、六硝基六氮杂异伍兹烷(CL-20)、高氯酸铵(AP)、Al、微晶蜡的相容性.结果表明:DNP的热分解过程分两个阶段,第一阶段DSC曲线的分解峰温出现在319.8℃,显示DNP有好的热稳定性,第二阶段DSC曲线峰温为407.2℃.DNP与DNAN、TNAZ、RDX、HMX、CL-20、AP、A1、微晶蜡均相容.这些物质可用作炸药组分.%Thermal behaviors of 3,4-dinitrophyrazole (DNP) were investigated by differential scanning calorimetry (DSC) and thermal gravity/differential thermal gravity(.TG-DTG).The compatibilities of DNP with some explosive component materials,including 2,4-dinitroanisole(DNAN),1,3,3-trinitroazetidine (TNAZ),cyclotrimethylene trinitramine (RDX),cyclotetramethylene tetranitramine(HMX),hexanitrohexaazaisowurtzitane(CL-20),ammonium perchlorate(AP),Al and m icrocrystal wax were discussed by vacuum stability test (VST) and DSC.Results show that thermal decomposition process of DNP can be divided into two stages.The peak temperature of DSC curve for the first stage is 319.8 ℃,which revealing that DNP has superior thermal stability.And the peak temperature of DSC curve for the second stage is 407.2 ℃.The compatibilities of DNP with DNAN,TNAZ,RDX,HMX,Cl-20,AP,Al and microcrystal wax are good.These materials can be used as components in explosives.

  13. Comparison and evaluation of five types of imidazole-modified silica adsorbents for the removal of 2,4-dinitrophenol from water samples with the methyl group at different positions of imidazolium ring

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhike, E-mail: wzk@htu.cn; Ye, Cunling; Li, Juan; Wang, Heping; Zhang, Han

    2013-09-15

    Highlights: • Five imidazole-modified silica adsorbents were synthesized. • The five adsorbents are of primary anion-exchange and electrostatic nature. • The electrostatic nature was affected by the methyl group of imidazolium ring. • The five adsorbents are suitable for adsorption of 2,4-DNP with low pK{sub a} value. • The adsorbent was regenerated and reused ten times by washings with HCl and water. -- Abstract: The objective of this work was to improve the understanding the influence of the methyl group at different positions of imidazolium ring on the adsorption behaviors of imidazole-modified silica adsorbents. Five adsorbents named as SilprImCl, SilprM{sub 1}ImCl, SilprM{sub 2}ImCl, SilprM{sub 4}ImCl and SilprM{sub 1}M{sub 2}ImCl were synthesized using imidazole, 1-methylimidazole, 2-methylimidazole, 4-methylimidazole and 1,2-dimethylimidazole, respectively. These adsorbents were characterized by scanning electron microscope, infrared spectra, thermogravimetric analysis, elemental analysis and BET analysis. Firstly, phenol, 2-nitrophenol (2-NP), 3-nitrophenol (3-NP), 4-nitrophenol (4-NP) and 2,4-dinitrophenol (2,4-DNP) were used as adsorbates to investigate the selectivity of SilprImCl and its adsorption capacities followed the order of 2,4-DNP ≫ 4-NP > 2-NP ≫ 3-NP > phenol. Therefore, 2,4-DNP was used to investigate the adsorption behaviors of the five adsorbents. It was inferred that the adsorbents are of primary anion-exchange and electrostatic nature. The electrostatic nature was affected significantly by the methyl group at different positions of imidazolium ring. The adsorbed amounts of 2,4-DNP decreased in the order of: SilprM{sub 1}M{sub 2}ImCl ≈ SilprM{sub 1}ImCl > SilprM{sub 4}ImCl > SilprM{sub 2}ImCl > SilprImCl. The adsorption–elution experiments indicated that 2,4-DNP can be removed from aqueous solutions by a SilprM{sub 4}ImCl packed column and the recovery of 91.6% was obtained. The adsorbent could be regenerated and reused

  14. Role of ATP in the sensitivity to heat and the induction of apoptosis in mammalian cells.

    Science.gov (United States)

    Miyazaki, N; Kurihara, K; Nakano, H; Shinohara, K

    2002-01-01

    Heat-induced cell death and apoptosis were studied with respect to intracellular ATP. Studies on the relationship between hyperthermic cell-killing at 44 degrees C and cellular ATP levels in four cell lines grown as monolayers and six cell lines grown in suspension showed good correlations between cellular ATP levels and the sensitivity to heat. D(0) values (the dose required to reduce survival in the linear portion of the response by 63%) linearly increased with an increase in cellular ATP levels. No such changes in sensitivity to heat were observed between the cells cultured at different cell densities, regardless of the change in the cellular ATP level. These results suggest that cellular intrinsic ability to supply ATP rather than the level of pooled ATP per se is responsible for the thermal response. Heat-induced apoptosis in L5178Y cells was observed following treatment at 42 degrees C for 70 min, 44 degrees C for 20 min or 47 degrees C for 3 min, which corresponded to surviving fractions of 25, 0.6 and 0.8%, respectively, but not at 47 degrees C for 20 min, indicating that mild heat shock induced apoptosis. 2-deoxyglucose (2DG) and 2,4-dinitrophenol (DNP) increased the sensitivity to heat and affected the mode of cell death. Cells treated with 2DG and DNP (2DG/DNP) were heated at 42 degrees C for 20 min, and then incubated at 37 degrees C for up to 2h in the presence or absence of 2DG/DNP. In the absence of 2DG/DNP, the cellular ATP level recovered to 76% of the control level and DNA ladder formation was observed, whereas in the presence of 2DG/DNP, the cellular ATP level was further decreased (3-7% of the control) and no DNA fragmentation was detected. These results suggest that the inhibition of ATP synthesis is closely associated with the enhancement of sensitivity to heat and that ATP is required for the induction of apoptosis.

  15. Extension of high T{sub e} regime with upgraded electron cyclotron resonance heating system in the Large Helical Device

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, H., E-mail: takahashi.hiromi@LHD.nifs.ac.jp; Shimozuma, T.; Kubo, S.; Yoshimura, Y.; Igami, H.; Ito, S.; Kobayashi, S.; Mizuno, Y.; Okada, K.; Mutoh, T.; Nagaoka, K.; Osakabe, M.; Yamada, I.; Nakano, H.; Yokoyama, M.; Ido, T.; Shimizu, A.; Seki, R.; Ida, K.; Yoshinuma, M. [National Institute for Fusion Science, Toki 509-5292 (Japan); and others

    2014-06-15

    Enhancement of the output power per gyrotron has been planned in the Large Helical Device (LHD). Three 77-GHz gyrotrons with an output power of more than 1 MW have been operated. In addition, a high power gyrotron with the frequency of 154 GHz (1 MW/5 s, 0.5 MW/CW) was newly installed in 2012, and the total injection power of Electron cyclotron resonance heating (ECRH) reached 4.6 MW. The operational regime of ECRH plasma on the LHD has been extended due to the upgraded ECRH system such as the central electron temperature of 13.5 keV with the line-averaged electron density n{sub e-fir} = 1 × 10{sup 19} m{sup −3}. The electron thermal confinement clearly improved inside the electron internal transport barrier, and the electron thermal diffusivity reached neoclassical level. The global energy confinement time increased with increase of n{sub e-fir}. The plasma stored energy of 530 kJ with n{sub e-fir} = 3.2 × 10{sup 19} m{sup −3}, which is 1.7 times larger than the previous record in the ECRH plasma in the LHD, has been successfully achieved.

  16. Self-consistent modeling of terahertz waveguide and cavity with frequency-dependent conductivity

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Y. J.; Chu, K. R., E-mail: krchu@yahoo.com.tw [Department of Physics, National Taiwan University, Taipei, Taiwan (China); Thumm, M. [IHM and IHE, Karlsruhe Institute of Technology, Karlsruhe (Germany)

    2015-01-15

    The surface resistance of metals, and hence the Ohmic dissipation per unit area, scales with the square root of the frequency of an incident electromagnetic wave. As is well recognized, this can lead to excessive wall losses at terahertz (THz) frequencies. On the other hand, high-frequency oscillatory motion of conduction electrons tends to mitigate the collisional damping. As a result, the classical theory predicts that metals behave more like a transparent medium at frequencies above the ultraviolet. Such a behavior difference is inherent in the AC conductivity, a frequency-dependent complex quantity commonly used to treat electromagnetics of metals at optical frequencies. The THz region falls in the gap between microwave and optical frequencies. However, metals are still commonly modeled by the DC conductivity in currently active vacuum electronics research aimed at the development of high-power THz sources (notably the gyrotron), although a small reduction of the DC conductivity due to surface roughness is sometimes included. In this study, we present a self-consistent modeling of the gyrotron interaction structures (a metallic waveguide or cavity) with the AC conductivity. The resulting waveguide attenuation constants and cavity quality factors are compared with those of the DC-conductivity model. The reduction in Ohmic losses under the AC-conductivity model is shown to be increasingly significant as the frequency reaches deeper into the THz region. Such effects are of considerable importance to THz gyrotrons for which the minimization of Ohmic losses constitutes a major design consideration.

  17. ECH system and its application to long pulse discharge in large helical device

    International Nuclear Information System (INIS)

    We have developed and constructed an ECH system for the large helical device (LHD). The ECH system consists of 0.5 MW, 84 GHz range and 168 GHz gyrotrons, high voltage power supplies, long distance transmission lines, and in-vessel quasi-optical antennas. It has been improved step by step. At the third campaign of LHD experiments, three 84 GHz range (two 82.6 GHz and one 84 GHz) and three 168 GHz gyrotrons are operated and ECH power can be injected from four antennas vertically and two horizontally. This complicated system is remotely controlled and monitored by fully GUI (Graphical User Interface) control panels realized on PC via TCP (transmission control protocol) communication. Over 10000 shots of gyrotron power have been injected steadily into the LHD during the experimental campaigns on this system. One line of the system (84 GHz line) is specially prepared for the experiments of steady state plasma production. Using this line, plasma sustainment for 2 min was successfully achieved by only ECH power. Injected ECH power was 50 kW with 95% duty factor. The electron density and temperature of the sustained plasma are measured to be 0.3-0.5x1018 m-3 and ∼650 eV. Ion temperature measured by Doppler broadening of the impurity radiation line was kept constant at ∼300 eV during RF injection

  18. ECH system and its application to long pulse discharge in large helical device

    Energy Technology Data Exchange (ETDEWEB)

    Shimozuma, T.; Kubo, S.; Sato, M.; Idei, H.; Takita, Y.; Ito, S.; Kobayashi, S.; Mizuno, Y.; Yoshimura, Y.; Ohkubo, K.; Funaba, H.; Inagaki, S.; Kobuchi, T.; Masuzaki, S.; Muto, S.; Shoji, M.; Suzuki, H.; Noda, N.; Nakamura, Y.; Kawahata, K.; Ohyabu, N.; Motojima, O

    2001-01-01

    We have developed and constructed an ECH system for the large helical device (LHD). The ECH system consists of 0.5 MW, 84 GHz range and 168 GHz gyrotrons, high voltage power supplies, long distance transmission lines, and in-vessel quasi-optical antennas. It has been improved step by step. At the third campaign of LHD experiments, three 84 GHz range (two 82.6 GHz and one 84 GHz) and three 168 GHz gyrotrons are operated and ECH power can be injected from four antennas vertically and two horizontally. This complicated system is remotely controlled and monitored by fully GUI (Graphical User Interface) control panels realized on PC via TCP (transmission control protocol) communication. Over 10000 shots of gyrotron power have been injected steadily into the LHD during the experimental campaigns on this system. One line of the system (84 GHz line) is specially prepared for the experiments of steady state plasma production. Using this line, plasma sustainment for 2 min was successfully achieved by only ECH power. Injected ECH power was 50 kW with 95% duty factor. The electron density and temperature of the sustained plasma are measured to be 0.3-0.5x10{sup 18} m{sup -3} and {approx}650 eV. Ion temperature measured by Doppler broadening of the impurity radiation line was kept constant at {approx}300 eV during RF injection.

  19. 60kV, 10Amp DC power supply multiple input control and monitoring provision for the operation of various high power RF generation systems

    International Nuclear Information System (INIS)

    A 60 kV, 10 A DC power supply is used for testing of high power RF and microwave tubes e.g. Klystron, Gyrotron. Two 500 kW, 3.7 GHz klystrons, and one 82.6 GHz Gyrotron are located in SST1 Hall where as 200 kW; 28 GHz Gyrotron is located in Aditya Hall. The same power supply is required to operate, control and monitor various systems at different locations with easy change over from one system to other as per experimental requirements. An off line, control change over system, is designed to accomplish the above requirements, with control panels installed at desired different locations. The input (0 to 11 kV) A.C. voltage to power supply is given from a motorized voltage variation system (VVS). The control panels provide indication of A.C. input voltage to power supply from 11 kV potential transformers of VVS. In addition, the control panel is provided with 11 kV circuit breaker status indication and control i.e. Emergency OFF switch. The control panels are designed and developed indigenously which are successfully installed and are in continuous use for the safe and easy operation of different high power rf systems from the same DC power supply. The paper presents the design of the controls, monitoring and indications. Safety aspects of the system are also highlighted.

  20. Millimeter wave study program. Final report

    International Nuclear Information System (INIS)

    The purpose of this program was to study the various approaches to building an amplifier to produce 100 kW or more cw power at 120 GHz to decide on an optimum approach, and to perform design calculations. The study has led to the conclusion that a cyclotron resonance amplifier (gyrotron) is the optimum approach for 100 kW and that this type of interaction offers the best possibilities for going to still higher power levels. This report includes discussion in depth of all the topics and approaches considered in the study. Sections 2 and 3 deal with output waveguide and window designs. The fourth section discusses linear-beam amplifiers. The fifth section considers periodic-beam (other than cyclotron resonance) devices. Cyclotron resonance devices are considered in detail. Arguments are given leading to the choice of the gyrotron as the optimum approach in section 7. Design calculations for a 100 kW gyrotron amplifier are given based on the background and theory presented in section 6

  1. 3.6MW Power Supply System of the 170GHz ECH&CD System in KSTAR

    Directory of Open Access Journals (Sweden)

    Joung Jin-Hyun

    2012-09-01

    Full Text Available A 3.6 MW (-66 kV/55 A Gyrotron power supply system was developed for the 170 GHz ECH&CD gyrotron system in KSTAR. This power supply system consists of Cathode Power Supply(CPS, Anode Power Supply(APS and Body Power Supply(BPS. The CPS is using the Pulse Step Modulation by the 32set of IGBT choppers. The respons time of Chopper is very fast. So the cathode voltaget is able to be controlled rapidly. The APS is a sort of voltage devider using zener and switch component. It was achieved 3kHz modulation operation. The BPS is combined the commercial power supply and special high voltage switches. It is very simple topology but 5kHz modulation was accomplished easily. Theses power supply system were installed and commissioned successfully in 2011. This paper presents the topology of the each power supply and test result for 170 GHz gyrotron in KSTAR.

  2. Photovoltaic Characteristics of a Naphthylamine Derivative

    Institute of Scientific and Technical Information of China (English)

    FU,Hui-Ying; SONG,Qun-Liang; SUN,Xiao-Yu; HOU,Xiao-Yuan; XIAO,Fei; SHAO,Bing-Xian

    2007-01-01

    Organic photovoltaic (OPV) cells were fabricated via vacuum vapor deposition with {4-[2-(3-dicyanomethylidene-5,5-dimethylcyclohexenyl)vinyl]phenyl}di(1-naphthyl)amine (DNP-2CN) as the electron donor,and fullerene (C60) as the electron acceptor. A thin film (10 nm) of tris(8-quinolinolato)aluminum (Alq3) was adopted as the buffer layer. A device based on this DNP-2CN exhibited an open circuit voltage (Voc) of 370 mV, a short-circuit current density (Jsc) of 0.61 mA·cm-2, and a white-light power conversion efficiency (η) of 0.09%(AM1.5, 75 mW·cm-2).

  3. Mutagenicity and Induction of Drug—metabolizing Enzyme Activity by LPG Combustion Particulates in Rats

    Institute of Scientific and Technical Information of China (English)

    YINXue-Jun; LIUJun-Zhuo; 等

    1994-01-01

    Methylene chloride extracts of particulates from liquefied petroleum gas(LPG)combustion appliance were studied by using Ames test,micronucleus test and inducibility of pulmonary and hepatic aryl hydrocarbon hydroxylase(AHH)and glutathione S-transferase(GST)in rats.The extracts showed mutagenicity for Salmonella typhimurium strain TA98 and its derivatives TA98NR and TA98/1,8-DNP6 with or without S9 mix.The revertants in strains TA98NR and TA98/1,8-DNP6 were less than 40%and 50% of than in strain TA98 without S9 mix,respectively.Positive results were obtained in mouse bone marrow micronucleus assay.Intratracheal instillation of the extracts led to increase in pulmonary(but not hepatic)AHH and GST activities in rats.In was seen that AHH was more sensitive than GST to induction by the extracts.

  4. Suppression of unprimed T and B cells in antibody responses by irradiation-resistant and plastic-adherent suppressor cells in Toxoplasma gondii-infected mice

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Y.; Kobayashi, A.

    1983-04-01

    In the acute phase of Toxoplasma infection, the function of both helper T and B cells was suppressed in primary antibody responses to dinitrophenol (DNP)-conjugated protein antigens. During the course of infection, the suppressive effect on T cells seems to continue longer than that on B cells, since suppression in responses to sheep erythrocytes, a T-dependent antigen, persisted longer than those to DNP-Ficoll, a T-independent antigen. Plastic-adherent cells from the spleens of Toxoplasma-infected and X-irradiated (400 rads) mice had strong suppressor activity in primary anti-sheep erythrocyte antibody responses of normal mouse spleen cells in vitro. These data suggest that the activation of irradiation-resistant and plastic-adherent suppressor cells causes the suppression of both T and B cells in Toxoplasma-infected mice.

  5. Innovación en hidrocarburos en Colombia

    Directory of Open Access Journals (Sweden)

    Juan Benavides Estévez-Bretón

    2011-01-01

    Full Text Available Este artículo presenta parte del Proyecto DNP- Uniandes sobre Clusters en la industria minero energética. El análisis se centrará en la innovación en hidrocarburos: primero, el planteamiento básico; segundo, los retos y oportunidades, y tercero, las líneas de acción en las que Colombia puede trabajar.//This article presents a fragment of the DNP- Uniandes project on Clusters in the energy mining industry. Specifically, the analysis focuses on innovation in hydrocarbons, starting with the project's basic approach. Next, it exposes the challenges and opportunities present in the Colombian context. Finally, it discusses the lines of action within which Colombia will move forward.

  6. The Distributed Network Processor: a novel off-chip and on-chip interconnection network architecture

    CERN Document Server

    Biagioni, Andrea; Lonardo, Alessandro; Paolucci, Pier Stanislao; Perra, Mersia; Rossetti, Davide; Sidore, Carlo; Simula, Francesco; Tosoratto, Laura; Vicini, Piero

    2012-01-01

    One of the most demanding challenges for the designers of parallel computing architectures is to deliver an efficient network infrastructure providing low latency, high bandwidth communications while preserving scalability. Besides off-chip communications between processors, recent multi-tile (i.e. multi-core) architectures face the challenge for an efficient on-chip interconnection network between processor's tiles. In this paper, we present a configurable and scalable architecture, based on our Distributed Network Processor (DNP) IP Library, targeting systems ranging from single MPSoCs to massive HPC platforms. The DNP provides inter-tile services for both on-chip and off-chip communications with a uniform RDMA style API, over a multi-dimensional direct network with a (possibly) hybrid topology.

  7. Specificity of the collagenolytic serine proteinase from the pancreas of the catfish (Parasilurus asotus).

    Science.gov (United States)

    Yoshinaka, R; Sato, M; Yamashita, M; Itoko, M; Ikeda, S

    1987-01-01

    The collagenolytic serine proteinase from the pancreas of the catfish (Parasilus asotus) had a pH optimum of 7.5 for native, reconstituted calf skin collagen fibrils. The enzyme was most stable at pH 6-9. The enzyme hydrolyzed heat-denatured collagen (gelatin), casein, hemoglobin and elastin in addition to native collagen but not virtually Tos-Arg-OEe, Bz-Tyr-OEe and Suc-(Ala)3-NA. The enzyme cleaved Leu-Gly (or Gln-Gly), Gly-Ile and Ile-Ala bonds on DNP-Pro-Leu-Gly-Ile-Ala-Gly-Arg-NH2 and DNP-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg. PMID:3480788

  8. Batrachochytrium dendrobatidis infection of amphibians in the Doñana National Park, Spain.

    Science.gov (United States)

    Hidalgo-Vila, Judit; Díaz-Paniagua, Carmen; Marchand, Marc A; Cunningham, Andrew A

    2012-03-20

    Amphibian chytridiomycosis, caused by infection with the non-hyphal, zoosporic chytrid fungus Batrachochytrium dendrobatidis (Bd), is an emerging infectious disease recognised as a cause of recent amphibian population declines and extinctions worldwide. The Doñana National Park (DNP) is located in southwestern Spain, a country with widespread Bd infection. This protected area has a great diversity of aquatic habitats that constitute important breeding habitats for 11 native amphibian species. We sampled 625 amphibians in December 2007 and February to March 2008, months that correspond to the early and intermediate breeding seasons for amphibians, respectively. We found 7 of 9 sampled species to be infected with Bd and found differences in prevalence between sampling periods. Although some amphibians tested had higher intensities of infection than others, all animals sampled were apparently healthy and, so far, there has been no evidence of either unusually high rates of mortality or amphibian population declines in the DNP.

  9. Suppressive activity of a macrolide antibiotic, roxithromycin on co-stimulatory molecule expression on mouse splenocytes in vivo

    Directory of Open Access Journals (Sweden)

    K. Kawazu

    2000-01-01

    Full Text Available The influence of roxithromycin (RXM on the expression of co-stimulatory molecules, CD40, CD80 and CD86, was examined in vivo. When BALB/c mice were immunized intraperitoneally with two doses of dinitrophenylated ovalbumin (DNP-OVA at 1 week intervals, intraperitoneal administration of RXM at 250 μg/kg once a day for 14 days strongly suppressed IgE contents in sera obtained from mice 22 days after the first immunization. In addition, RXM treatment of mice suppressed endogenous IL–4 contents in aqueous spleen extracts, which were enhanced by DNP-OVA immunization. We next examined the influence of RXM on co-stimulatory molecule expression on splenic lymphocytes. RXM treatment of the immunized mice caused suppression of CD40 expression, but this treatment did not affect CD80 and CD86 expression.

  10. Magnetic resonance imaging without field cycling at less than earth's magnetic field

    Science.gov (United States)

    Lee, Seong-Joo; Shim, Jeong Hyun; Kim, Kiwoong; Yu, Kwon Kyu; Hwang, Seong-min

    2015-03-01

    A strong pre-polarization field, usually tenths of a milli-tesla in magnitude, is used to increase the signal-to-noise ratio in ordinary superconducting quantum interference device-based nuclear magnetic resonance/magnetic resonance imaging experiments. Here, we introduce an experimental approach using two techniques to remove the need for the pre-polarization field. A dynamic nuclear polarization (DNP) technique enables us to measure an enhanced resonance signal. In combination with a π / 2 pulse to avoid the Bloch-Siegert effect in a micro-tesla field, we obtained an enhanced magnetic resonance image by using DNP technique with a 34.5 μT static external magnetic field without field cycling. In this approach, the problems of eddy current and flux trapping in the superconducting pickup coil, both due to the strong pre-polarization field, become negligible.

  11. Initiation of furazanotetrazinedioxide and mixes on its basis by high-current electron beam

    International Nuclear Information System (INIS)

    The results of study of physicochemical processes developing in the samples of furazanotetrazinedioxide (FTDO) and its mixes with dinitrodiazapentane (DNP) upon irradiation by the high-current electron beam with the energy density varied in the range of 0.05-60 J/cm2 are presented. Pre-explosion processes taking place in materials under examination at below threshold modes of excitation are studied. Electron beam threshold energy densities leading to explosive decomposition of FTDO and FTDO/DNP mixes are determined. Noticeable effect of the electron beam energy density on kinetic characteristics of explosive decomposition process of FTDO is discovered. Spectra of the products of FTDO explosive decomposition are measured at explosion initiation in the atmosphere

  12. Consenso experto sobre el uso clínico de los tratamientos por vía tópica en el manejo del dolor neuropático periférico

    Directory of Open Access Journals (Sweden)

    C. Pérez

    2013-12-01

    Full Text Available Objetivo: Proponer a partir del consenso de un panel de expertos de ámbito estatal que integre la experiencia clínica y la evidencia disponible más actual, recomendaciones sobre el uso clínico de los tratamientos por vía tópica para el manejo del dolor neuropático periférico (DNP. Métodos: Se proponen, a partir de una revisión bibliográfica sobre las distintas opciones terapéuticas tópicas en DNP, una serie de criterios profesionales y recomendaciones clínicas para la mejora del uso de dichos agentes tópicos. Se empleó el método Delphi modificado en dos rondas para contrastar las opiniones de un panel nacional de 52 reconocidos expertos, seleccionados mediante una estrategia en "bola de nieve" de entre el colectivo de anestesiólogos de unidades del dolor (94 % y otros especialistas (neurólogos y traumatólogos. Se evaluaron 61 recomendaciones clínicas agrupadas en 6 áreas temáticas: a DNP: tratamiento tópico versus sistémico (11 ítems; b dolor neuropático postquirúrgico, postraumático y muñones dolorosos (12 ítems; c neuralgia posherpética, intercostal y del trigémino (9 ítems; d DNP por atrapamiento (8 ítems; e síndrome de dolor regional complejo (11 ítems; y f neuropatía diabética (ND y otras polineuropatías (por VIH, alcohol, toxicidad, etc. (10 ítems. Se empleó una escala ordinal de tipo Likert de 9 puntos (desacuerdo/acuerdo para evaluar cada recomendación. Tras la primera ronda de encuesta, se facilitó al panel información del resultado (resultados estadísticos y opiniones libres de los panelistas y se solicitó la reconsideración del voto sobre los ítems no consensuados. Resultados: Tras la primera ronda del panel se logró consenso en 37 de las 61 cuestiones planteadas. Al final de la segunda ronda el acuerdo ascendió hasta 46 ítems (75 %. En general, se aprecia consenso entre los expertos sobre la conveniencia de introducir los tratamientos tópicos en primera línea de tratamiento del

  13. THz-waves channeling in a monolithic saddle-coil for Dynamic Nuclear Polarization enhanced NMR.

    Science.gov (United States)

    Macor, A; de Rijk, E; Annino, G; Alberti, S; Ansermet, J-Ph

    2011-10-01

    A saddle coil manufactured by electric discharge machining (EDM) from a solid piece of copper has recently been realized at EPFL for Dynamic Nuclear Polarization enhanced Nuclear Magnetic Resonance experiments (DNP-NMR) at 9.4 T. The corresponding electromagnetic behavior of radio-frequency (400 MHz) and THz (263 GHz) waves were studied by numerical simulation in various measurement configurations. Moreover, we present an experimental method by which the results of the THz-wave numerical modeling are validated. On the basis of the good agreement between numerical and experimental results, we conducted by numerical simulation a systematic analysis on the influence of the coil geometry and of the sample properties on the THz-wave field, which is crucial in view of the optimization of DNP-NMR in solids.

  14. Magnetic resonance imaging without field cycling at less than earth's magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seong-Joo, E-mail: sj.lee@kriss.re.kr; Shim, Jeong Hyun; Kim, Kiwoong; Yu, Kwon Kyu; Hwang, Seong-min [Center for Biosignals, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon 305-340 (Korea, Republic of)

    2015-03-09

    A strong pre-polarization field, usually tenths of a milli-tesla in magnitude, is used to increase the signal-to-noise ratio in ordinary superconducting quantum interference device-based nuclear magnetic resonance/magnetic resonance imaging experiments. Here, we introduce an experimental approach using two techniques to remove the need for the pre-polarization field. A dynamic nuclear polarization (DNP) technique enables us to measure an enhanced resonance signal. In combination with a π/2 pulse to avoid the Bloch-Siegert effect in a micro-tesla field, we obtained an enhanced magnetic resonance image by using DNP technique with a 34.5 μT static external magnetic field without field cycling. In this approach, the problems of eddy current and flux trapping in the superconducting pickup coil, both due to the strong pre-polarization field, become negligible.

  15. THz-waves channeling in a monolithic saddle-coil for Dynamic Nuclear Polarization enhanced NMR

    Science.gov (United States)

    Macor, A.; de Rijk, E.; Annino, G.; Alberti, S.; Ansermet, J.-Ph.

    2011-10-01

    A saddle coil manufactured by electric discharge machining (EDM) from a solid piece of copper has recently been realized at EPFL for Dynamic Nuclear Polarization enhanced Nuclear Magnetic Resonance experiments (DNP-NMR) at 9.4 T. The corresponding electromagnetic behavior of radio-frequency (400 MHz) and THz (263 GHz) waves were studied by numerical simulation in various measurement configurations. Moreover, we present an experimental method by which the results of the THz-wave numerical modeling are validated. On the basis of the good agreement between numerical and experimental results, we conducted by numerical simulation a systematic analysis on the influence of the coil geometry and of the sample properties on the THz-wave field, which is crucial in view of the optimization of DNP-NMR in solids.

  16. Study of a number of biochemical indices of the blood and tissue of dogs after prolonged gamma-radiation

    Science.gov (United States)

    Alers, I.; Alersova, E.; Praslichka, T.; Mishurova, E.; Sedlakova, A.; Malatova, Z.; Akhunov, A. A.; Markelov, B. A.

    1974-01-01

    The glucose content in blood and the lipid content in serum and tissues of dogs exposed to chronic radiation for 3 and 5 years were studied. In tissues of these animals, the concentration of soluble DNA and DNA contained in DNP was studied in the spleen, lymph node (deep cervical node) and bone marrow of thigh bones. Results indicate that chronic gamma irradiation significantly changes concentrations of glucose in the blood, and that of several lipids in serum and tissues. A reduction in the concentration of DNP in tested organs reflects changes in the relative number of cells with various nuclear cytoplasmic ratios; most pronounced changes in biochemical indices occur in dogs exposed to chronic gamma radiation in doses of 125 rad per year.

  17. Post-Electrophoretic Identification of Oxidized Proteins

    Directory of Open Access Journals (Sweden)

    Conrad Craig

    2000-01-01

    Full Text Available The oxidative modification of proteins has been shown to play a major role in a number of human diseases. However, the ability to identify specific proteins that are most susceptible to oxidative modifications is difficult. Separation of proteins using polyacrylamide gel electrophoresis (PAGE offers the analytical potential for the recovery, amino acid sequencing, and identification of thousands of individual proteins from cells and tissues. We have developed a method to allow underivatized proteins to be electroblotted onto PVDF membranes before derivatization and staining. Since both the protein and oxidation proteins are quantifiable, the specific oxidation index of each protein can be determined. The optimal sequence and conditions for the staining process are (a electrophoresis, (b electroblotting onto PVDF membranes, (c derivatization of carbonyls with 2,4-DNP, (d immunostaining with anti DNP antibody, and (e protein staining with colloidal gold.

  18. ["E" rosette formation in "active" T lymphocytes: phenomenon modulated by intracellular level of cyclic AMP and GMP (author's transl)].

    Science.gov (United States)

    Machado, J A; Antunes, L J; Silva, E N

    1977-08-01

    The rosette formation envolving the binding of sheep red blood cells (SRBC) with active T lymphocytes was activated when the lymphocytes were incubated with levamisole, acetylcholine or carbamylcholine. Similar activation was seen when to the incubation medium was added substances of glucose metabolism (lactate, fumarate or succinate) or triphosphate de adenosina--ATP. The lymphocytes incubation with aminophyline, isoproterenol or 2-4-dinitrofenol--DNP--inhibited the rosette formation. The inhibition promoted by aminophyline was reversed by levamisole, acetylcholine or carbamylcholine, but not when lactate or ATP was used. When the rosette formation inhibition was caused by DNP, the reversion was only possible by ATP and no affect occurred if guanil cyclase activators were added to the incubation medium.

  19. Investigation of a 140 GHz gryo-backward wave oscillator and a 95 GHz gyro-traveling wave

    International Nuclear Information System (INIS)

    There is current interest in developing a high-power source of continuously tunable millimeter wave radiation as a RF driver for high-power gyrotron, CARM, or FEL amplifiers. The gyrotron backward wave oscillator is a voltage-tunable fast-wave device that can satisfy these requirements. This thesis reports on the design and experimental investigation of a 130--145 GHz gyrotron backward wave oscillator Novel operating features of this design include the use of a 80-kV, 6.2-A Pierce-wiggler electron beam source, a broadband motheye window and an overmoded TE1,2 cylindrical interaction waveguide. Although this device has demonstrated voltage-tunable operation over the design range in the TE1,2 mode, the frequency tuning is not continuous, output powers were low and full-beam transmission through the interaction region was not possible. Simulations indicate that the beam has very high velocity spread induced by space charge forces in the compression region. After increasing the diameter of the beam tunnel to achieve full transmission, the TE1,2 was not found. It is felt that the scraping off of the beam edge in the initial experiments allowed a better quality beam to enter the interaction region and inhibited coupling into competing forward wave modes. The need for radar systems with greater resolution has led to renewed interest in the development of efficient high-power amplifiers at 95 GHz. Current sources are limited to 6--8 kW of output power due to ohmic loading on the slow-wave circuit. A gyrotron traveling wave tube amplifier is capable of efficient operation over a wide bandwidth with the added attraction of low ohmic loading on the smooth fast-wave circuit. This thesis reports of the design a 95-GHz gyrotron traveling wave tube amplifier that is capable of high power (125 kW), high gain (38 dB), large bandwidth > 5 GHz and high efficiencies (> 30%)

  20. Mechanistic Analysis of the Effect of Deamidation on the Immunogenicity of Anthrax Protective Antigen.

    Science.gov (United States)

    Verma, Anita; Ngundi, Miriam M; Burns, Drusilla L

    2016-05-01

    The spontaneous modification of proteins, such as deamidation of asparagine residues, can significantly affect the immunogenicity of protein-based vaccines. Using a "genetically deamidated" form of recombinant protective antigen (rPA), we have previously shown that deamidation can decrease the immunogenicity of rPA, the primary component of new-generation anthrax vaccines. In this study, we investigated the biochemical and immunological mechanisms by which deamidation of rPA might decrease the immunogenicity of the protein. We found that loss of the immunogenicity of rPA vaccine was independent of the presence of adjuvant. We assessed the effect of deamidation on the immunodominant neutralizing B-cell epitopes of rPA and found that these epitopes were not significantly affected by deamidation. In order to assess the effect of deamidation on T-cell help for antibody production elicited by rPA vaccine, we examined the ability of the wild-type and genetically deamidated forms of rPA to serve as hapten carriers. We found that when wild-type and genetically deamidated rPA were modified to similar extents with 2,4-dinitrophenyl hapten (DNP) and then used to immunize mice, higher levels of anti-DNP antibodies were elicited by wild-type DNP-rPA than those elicited by the genetically deamidated DNP-rPA, indicating that wild-type rPA elicits more T-cell help than the genetically deamidated form of the protein. These results suggest that a decrease in the ability of deamidated rPA to elicit T-cell help for antibody production is a possible contributor to its lower immunogenicity. PMID:26912784

  1. Polyunsaturated fatty acids in amyotrophic lateral sclerosis: role of DHA, peroxidative modifications and sexual dimorphism

    OpenAIRE

    Cacabelos Barral, Daniel

    2014-01-01

    In the present work we focus into the potential relevance of PUFAs in some models and human samples from patients suffering amyotrophic lateral sclerosis (ALS). Due to its pathological implication, oxidative stress was our first goal. We started from simple oxidative methodology screening to search for an antioxidant substance (among 21 different candidates) available in a Mediterranean diet. The results demonstrated high heterogeneity in carbonyl (measured by DNP) accumulation...

  2. Écologie trophique du Chacal doré dans le Parc National du Djurdjura (Kabylie, Algérie) = Trophic ecology of the Golden Jackal in Djurdjura National Park (Kabylie, Algeria)

    OpenAIRE

    Amroun, M.; Oubellil, D.; Gaubert, Philippe

    2014-01-01

    Since the rediscovery of the African Wolf, a certain level of uncertainty surrounds the ecological status of the golden Jackal in northern Africa. We characterized the trophic spectrum of the 'Golden Jackal' phenotype (distinct from the 'African Wolf' phenotype) and its possible seasonal variations in relation with availability of resources (waste included) in the Djurdjura National Park (DNP), northern Algeria. The analysis of 360 faeces collected over one year shows that 91 % of the items c...

  3. A Secure, Intelligent, and Smart-Sensing Approach for Industrial System Automation and Transmission over Unsecured Wireless Networks

    Directory of Open Access Journals (Sweden)

    Aamir Shahzad

    2016-03-01

    Full Text Available In Industrial systems, Supervisory control and data acquisition (SCADA system, the pseudo-transport layer of the distributed network protocol (DNP3 performs the functions of the transport layer and network layer of the open systems interconnection (OSI model. This study used a simulation design of water pumping system, in-which the network nodes are directly and wirelessly connected with sensors, and are monitored by the main controller, as part of the wireless SCADA system. This study also intends to focus on the security issues inherent in the pseudo-transport layer of the DNP3 protocol. During disassembly and reassembling processes, the pseudo-transport layer keeps track of the bytes sequence. However, no mechanism is available that can verify the message or maintain the integrity of the bytes in the bytes received/transmitted from/to the data link layer or in the send/respond from the main controller/sensors. To properly and sequentially keep track of the bytes, a mechanism is required that can perform verification while bytes are received/transmitted from/to the lower layer of the DNP3 protocol or the send/respond to/from field sensors. For security and byte verification purposes, a mechanism needs to be proposed for the pseudo-transport layer, by employing cryptography algorithm. A dynamic choice security buffer (SB is designed and employed during the security development. To achieve the desired goals of the proposed study, a pseudo-transport layer stack model is designed using the DNP3 protocol open library and the security is deployed and tested, without changing the original design.

  4. Transient elevation of glycolysis confers radio-resistance by facilitating DNA repair in cells

    OpenAIRE

    Bhatt, Anant Narayan; Chauhan, Ankit; Khanna, Suchit; Rai, Yogesh; Singh, Saurabh; Soni, Ravi; Kalra, Namita; Bilikere S Dwarakanath

    2015-01-01

    Background Cancer cells exhibit increased glycolysis for ATP production (the Warburg effect) and macromolecular biosynthesis; it is also linked with therapeutic resistance that is generally associated with compromised respiratory metabolism. Molecular mechanisms underlying radio-resistance linked to elevated glycolysis remain incompletely understood. Methods We stimulated glycolysis using mitochondrial respiratory modifiers (MRMs viz. di-nitro phenol, DNP; Photosan-3, PS3; Methylene blue, MB)...

  5. Fine-tuning the space, time, and host distribution of mycobacteria in wildlife

    Directory of Open Access Journals (Sweden)

    de la Fuente Jose

    2011-02-01

    Full Text Available Abstract Background We describe the diversity of two kinds of mycobacteria isolates, environmental mycobacteria and Mycobacterium bovis collected from wild boar, fallow deer, red deer and cattle in Doñana National Park (DNP, Spain, analyzing their association with temporal, spatial and environmental factors. Results High diversity of environmental mycobacteria species and M. bovis typing patterns (TPs were found. When assessing the factors underlying the presence of the most common types of both environmental mycobacteria and M. bovis TPs in DNP, we evidenced (i host species differences in the occurrence, (ii spatial structuration and (iii differences in the degree of spatial association of specific types between host species. Co-infection of a single host by two M. bovis TPs occurred in all three wild ungulate species. In wild boar and red deer, isolation of one group of mycobacteria occurred more frequently in individuals not infected by the other group. While only three TPs were detected in wildlife between 1998 and 2003, up to 8 different ones were found during 2006-2007. The opposite was observed in cattle. Belonging to an M. bovis-infected social group was a significant risk factor for mycobacterial infection in red deer and wild boar, but not for fallow deer. M. bovis TPs were usually found closer to water marshland than MOTT. Conclusions The diversity of mycobacteria described herein is indicative of multiple introduction events and a complex multi-host and multi-pathogen epidemiology in DNP. Significant changes in the mycobacterial isolate community may have taken place, even in a short time period (1998 to 2007. Aspects of host social organization should be taken into account in wildlife epidemiology. Wildlife in DNP is frequently exposed to different species of non-tuberculous, environmental mycobacteria, which could interact with the immune response to pathogenic mycobacteria, although the effects are unknown. This research

  6. Observation of strongly forbidden solid effect dynamic nuclear polarization transitions via electron-electron double resonance detected NMR

    OpenAIRE

    Smith, Albert A.; Corzilius, Björn; Haze, Olesya; Swager, Timothy M.; Griffin, Robert G.

    2013-01-01

    We present electron paramagnetic resonance experiments for which solid effect dynamic nuclear polarization transitions were observed indirectly via polarization loss on the electron. This use of indirect observation allows characterization of the dynamic nuclear polarization (DNP) process close to the electron. Frequency profiles of the electron-detected solid effect obtained using trityl radical showed intense saturation of the electron at the usual solid effect condition, which involves a s...

  7. Simultaneous biodegradation of nitrogen-containing aromatic compounds in a sequencing batch bioreactor

    Institute of Scientific and Technical Information of China (English)

    LIU Xing-yu; WANG Bao-jun; JIANG Cheng-ying; ZHAO Ke-xin; Harold L.Drake; LIU Shuang-Jiang

    2007-01-01

    Many nitrogen-containing aromatic compounds (NACs), such as nitrobenzene (NB), 4-nitrophenol (4-NP), aniline (AN), and 2,4-dinitrophenol (2,4-DNP), are environmentally hazardous, and their removal from contaminated water is one of the main challenges facing wastewater treatment plants. In this study, synthetic wastewater containing NB, 4-NP, 2,4-DNP, and AN at concentrations ranging from 50 to 180 mg/L was fed into a sequencing batch reactor (SBR). Analyses of the SBR system indicated that it simultaneously removed more than 99% of the NACs at loading rates of 0.36 kg NB/(m3·d), 0.3 kg 4-NP/(m3·d), 0.25 kg AN/(m3·d), and 0.1 kg 2,4-DNP/(m3·d). Bacterial groups of Bacteriodetes, Candidate division TM7, α-Proteobacteria, and β-Proteobacteria were dominant in the clone libraries of 16S rRNA genes retrieved from the microbial communities in the SBR system. "Cycle tests" designed to alter feeding and aeration parameters of the SBR system demonstrated that the resident microbial biome of the SBR system responded rapidly to changing conditions. Consumption of O2 was concomitant with the apparent mineralization of NACs. Aromatic ring-cleaving dioxygenase activities suggested that (1) AN and NB were degraded via catechol 2,3-dioxygenase; (2) 4-NP was degraded via 1,2,4-benzentriol 1,2-dioxygenase; and (3) 2,4-DNP was degraded via an unresolved pathway.

  8. Selective Imaging of Malignant Ascites in a Mouse Model of Peritoneal Metastasis Using in Vivo Dynamic Nuclear Polarization-Magnetic Resonance Imaging.

    Science.gov (United States)

    Eto, Hinako; Hyodo, Fuminori; Nakano, Kenji; Utsumi, Hideo

    2016-02-16

    The presence of malignant ascites in advanced cancer patients is associated with both a poor prognosis and quality of life with a risk of abdominal infection and sepsis. Contemporary noninvasive visualization methods such as ultrasound, computed tomography, and magnetic resonance imaging (MRI) often struggle to differentiate malignant ascites from surrounding tissues. This study aimed to determine the utility of selective H2O imaging in the abdominal cavity with a free radical probe and deuterium oxide (D2O) contrast agent using in vivo dynamic nuclear polarization-MRI (DNP-MRI). Phantom imaging experiments established a linear relationship between H2O volume and image intensity using in vivo DNP-MRI. Similar results were obtained when the radical-D2O probe was used to determine selective and spatial information on H2O in vivo, modeled by the injection of saline into the abdominal cavity of mice. To demonstrate the utility of this method for disease, malignant ascites in peritoneal metastasis animal model was selected as one of the typical examples. In vivo DNP-MRI of peritoneal metastasis animal model was performed 7-21 days after intraperitoneal injection of luciferase, stably expressing the human pancreatic carcinoma (SUIT-2). The image intensity with increasing malignant ascites was significantly increased at days 7, 16, and 21. This increase corresponded to in vivo tumor progression, as measured by bioluminescent imaging. These results suggest that H2O signal enhancement in DNP-MRI using radical-D2O contrast is positively associated with the progression of dissemination and could be a useful biomarker for malignant ascites with cancer metastasis.

  9. A Secure, Intelligent, and Smart-Sensing Approach for Industrial System Automation and Transmission over Unsecured Wireless Networks

    Science.gov (United States)

    Shahzad, Aamir; Lee, Malrey; Xiong, Neal Naixue; Jeong, Gisung; Lee, Young-Keun; Choi, Jae-Young; Mahesar, Abdul Wheed; Ahmad, Iftikhar

    2016-01-01

    In Industrial systems, Supervisory control and data acquisition (SCADA) system, the pseudo-transport layer of the distributed network protocol (DNP3) performs the functions of the transport layer and network layer of the open systems interconnection (OSI) model. This study used a simulation design of water pumping system, in-which the network nodes are directly and wirelessly connected with sensors, and are monitored by the main controller, as part of the wireless SCADA system. This study also intends to focus on the security issues inherent in the pseudo-transport layer of the DNP3 protocol. During disassembly and reassembling processes, the pseudo-transport layer keeps track of the bytes sequence. However, no mechanism is available that can verify the message or maintain the integrity of the bytes in the bytes received/transmitted from/to the data link layer or in the send/respond from the main controller/sensors. To properly and sequentially keep track of the bytes, a mechanism is required that can perform verification while bytes are received/transmitted from/to the lower layer of the DNP3 protocol or the send/respond to/from field sensors. For security and byte verification purposes, a mechanism needs to be proposed for the pseudo-transport layer, by employing cryptography algorithm. A dynamic choice security buffer (SB) is designed and employed during the security development. To achieve the desired goals of the proposed study, a pseudo-transport layer stack model is designed using the DNP3 protocol open library and the security is deployed and tested, without changing the original design. PMID:26950129

  10. Dynamic Nuclear Polarization NMR Enables the Analysis of Sn-Beta Zeolite Prepared with Natural Abundance 119Sn Precursors

    OpenAIRE

    Gunther, William R.; Michaelis, Vladimir K.; Caporini, Marc A.; Griffin, Robert G.; Román-Leshkov, Yuriy

    2014-01-01

    The catalytic activity of tin-containing zeolites, such as Sn-Beta, is critically dependent on the successful incorporation of the tin metal center into the zeolite framework. However, synchrotron-based techniques or solid-state nuclear magnetic resonance (ssNMR) of samples enriched with 119Sn isotopes are the only reliable methods to verify framework incorporation. This work demonstrates, for the first time, the use of dynamic nuclear polarization (DNP) NMR for characterizing zeolites contai...

  11. Evaluation of Baffle Fixes Film up Flow Sludge Blanket Filtration (BFUSBF) System in Treatment of Wastewaters from Phenol and 2,4-Dinitrophenol Using Daphnia Magna Bioassay

    OpenAIRE

    Mohammad Javad Ghannadzadeh; Ahmad Jonidi Jafari; Abbas Rezaee; Fatemeh Eftekharian; Ali Koolivand

    2016-01-01

    Background: Phenol and nitrophenol are common compounds found in different types of industrial wastewater known as serious threats to human health and natural environment. In this study, Daphnia magna was used to evaluate the effectiveness of "baffle fixes film up flow sludge blanket filtration" (BFUSBF) system in elimination of phenolic compounds from water. Methods: D. magna cultures were used as toxicity index of phenol and 2,4-DNP mixtures after treatment by a pilot BFUSBF system which...

  12. Principle and application of hyperpolarized magnetic resonance spectroscopy%超极化磁共振波谱的原理和应用

    Institute of Scientific and Technical Information of China (English)

    齐海云; Christoffer Laustsen; Hans Stødkilde-Jørgensen; 张晓璐; 徐雅芳; 文建国; 许予明; 程敬亮; Albert P. Chen; Lotte Bonde Bertelsen; Steffen Ringgaard

    2015-01-01

    通过动态核极化(dynamic nuclear polarization,DNP)的方法使原子核自旋极化达到热平衡之上来增强分子磁共振10,000倍以上的信号,这一过程称为超极化(hyperpolarization,HP)。溶解性DNP允许超极化分子以液体形式转移至生物体内,可实时观测体内的生物灌注、代谢产物的运输和代谢反应。该技术的发明克服了传统磁共振信号低,不能实时监测体内代谢过程的缺点。本文旨在介绍动态核极化的定义和技术、常用的超极化生物探针、超极化磁共振波谱图像的结果分析以及初步的动物实验和临床试验结果。%The polarization of nuclear spins can be enhanced above the thermal equilibrium polarization with dynamic nuclear polarization (DNP) to achieve signal-noise ratio improvement of greater than 10,000-fold in magnetic resonance, this technique is denoted "hyperpolarization"(HP). Dissolution DNP is allowed the enhanced sample to be transferred from the polarizer and injected in vivo, providing realtime measurement of perfusion, metabolite transport, and metabolism, which break the constraint of traditional magnetic resonance in detecting cellular metabolism in real time in vivo. The deifnition and introduction to the DNP technique, hyperpolarized bio-probes and applications, and analysis and interpretation of results from magnetic resonance images/spectroscope in pre-clinical and clinical areas were reviewed.

  13. UCP2- and non-UCP2-mediated electric current in eukaryotic cells exhibits different properties.

    Science.gov (United States)

    Wang, Ruihua; MoYung, K C; Zhang, M H; Poon, Karen

    2015-12-01

    Using live eukaryotic cells, including cancer cells, MCF-7 and HCT-116, normal hepatocytes and red blood cells in anode and potassium ferricyanide in cathode of MFC could generate bio-based electric current. Electrons and protons generated from the metabolic reaction in both cytosol and mitochondria contributing to the leaking would mediate the generation of electric current. Both resveratrol (RVT) and 2,4-dinitrophenol (DNP) used to induce proton leak in mitochondria were found to promote electric current production in all cells except red blood cells without mitochondria. Proton leak might be important for electric current production by bringing the charge balance in cells to enhance the further electron leak. The induced electric current by RVT can be blocked by Genipin, an inhibitor of UCP2-mediated proton leak, while that induced by DNP cannot. RVT could reduce reactive oxygen species (ROS) level in cells better than that of DNP. In addition, RVT increased mitochondrial membrane potential (MMP), while DNP decreased it. Results highly suggested the existence of at least two types of electric current that showed different properties. They included UCP2-mediated and non-UCP2-mediated electric current. UCP2-mediated electric current exhibited higher reactive oxygen species (ROS) reduction effect per unit electric current production than that of non-UCP2-mediated electric current. Higher UCP2-mediated electric current observed in cancer cells might contribute to the mechanism of drug resistence. Correlation could not be established between electric current production with either ROS and MMP without distinguishing the types of electric current.

  14. Thermal Analysis of Whole Bacterial Cells Exposed to Potassium Permanganate Using Differential Scanning Calorimetry: a Biphasic Dose-Dependent Response to Stress

    Directory of Open Access Journals (Sweden)

    Marina K. Abuladze

    2009-01-01

    Full Text Available Differential scanning calorimetry (DSC was applied to estimate the impact of the toxic oxidant potassium permanganate (PM on the intracellular structural and functional alterations at whole cell level using soil bacteria Arthrobacter oxydans as a model culture. Differential scanning calorimetry (DSC was applied in order to estimate the impact of the toxic oxidant potassium permanganate (PM on the intracellular structural and functional alterations at the whole cell level using the soil bacteria Arthrobacter oxydans as a model culture. We compared the total melting heat and the temperature of DNA-protein complex (DNP melting at the PM application prior to the calorimetry measurement and after 24-h exposure at the concentration range 0.02–1.4 mM. The initial oxidative effect caused changes in the pattern of the whole cell melting spectra (mainly at the temperature range 56–78°C, the decrease of Tmax °C DNP melting, and did not influence significantly the total heat of bacterial melting at different concentrations of PM. The prolonged effect of permanganate up to 24 h was characterized by a biphasic dose-dependent response to stress estimated by the DSC technique and the colony-forming assay. The low doses of PM (0.02 and 0.2 mM stimulated cell proliferation, and increased the total whole cell melting heat and the temperature of DNP melting. The toxic effect of PM up to 0.04 mM reduced cell viability, changed the character of multipeaked thermograms, and lowered the total melting heat and the temperature of DNP melting in a concentration-dependent manner. This study presents the DSC method for evaluating and monitoring the effects of exposure to potential human and environmental toxicants.

  15. A Secure, Intelligent, and Smart-Sensing Approach for Industrial System Automation and Transmission over Unsecured Wireless Networks.

    Science.gov (United States)

    Shahzad, Aamir; Lee, Malrey; Xiong, Neal Naixue; Jeong, Gisung; Lee, Young-Keun; Choi, Jae-Young; Mahesar, Abdul Wheed; Ahmad, Iftikhar

    2016-01-01

    In Industrial systems, Supervisory control and data acquisition (SCADA) system, the pseudo-transport layer of the distributed network protocol (DNP3) performs the functions of the transport layer and network layer of the open systems interconnection (OSI) model. This study used a simulation design of water pumping system, in-which the network nodes are directly and wirelessly connected with sensors, and are monitored by the main controller, as part of the wireless SCADA system. This study also intends to focus on the security issues inherent in the pseudo-transport layer of the DNP3 protocol. During disassembly and reassembling processes, the pseudo-transport layer keeps track of the bytes sequence. However, no mechanism is available that can verify the message or maintain the integrity of the bytes in the bytes received/transmitted from/to the data link layer or in the send/respond from the main controller/sensors. To properly and sequentially keep track of the bytes, a mechanism is required that can perform verification while bytes are received/transmitted from/to the lower layer of the DNP3 protocol or the send/respond to/from field sensors. For security and byte verification purposes, a mechanism needs to be proposed for the pseudo-transport layer, by employing cryptography algorithm. A dynamic choice security buffer (SB) is designed and employed during the security development. To achieve the desired goals of the proposed study, a pseudo-transport layer stack model is designed using the DNP3 protocol open library and the security is deployed and tested, without changing the original design. PMID:26950129

  16. A Secure, Intelligent, and Smart-Sensing Approach for Industrial System Automation and Transmission over Unsecured Wireless Networks.

    Science.gov (United States)

    Shahzad, Aamir; Lee, Malrey; Xiong, Neal Naixue; Jeong, Gisung; Lee, Young-Keun; Choi, Jae-Young; Mahesar, Abdul Wheed; Ahmad, Iftikhar

    2016-03-03

    In Industrial systems, Supervisory control and data acquisition (SCADA) system, the pseudo-transport layer of the distributed network protocol (DNP3) performs the functions of the transport layer and network layer of the open systems interconnection (OSI) model. This study used a simulation design of water pumping system, in-which the network nodes are directly and wirelessly connected with sensors, and are monitored by the main controller, as part of the wireless SCADA system. This study also intends to focus on the security issues inherent in the pseudo-transport layer of the DNP3 protocol. During disassembly and reassembling processes, the pseudo-transport layer keeps track of the bytes sequence. However, no mechanism is available that can verify the message or maintain the integrity of the bytes in the bytes received/transmitted from/to the data link layer or in the send/respond from the main controller/sensors. To properly and sequentially keep track of the bytes, a mechanism is required that can perform verification while bytes are received/transmitted from/to the lower layer of the DNP3 protocol or the send/respond to/from field sensors. For security and byte verification purposes, a mechanism needs to be proposed for the pseudo-transport layer, by employing cryptography algorithm. A dynamic choice security buffer (SB) is designed and employed during the security development. To achieve the desired goals of the proposed study, a pseudo-transport layer stack model is designed using the DNP3 protocol open library and the security is deployed and tested, without changing the original design.

  17. Visualization of rDNA spacer transcription in Xenopus oocytes treated with fluorouridine

    OpenAIRE

    Rungger, M.; Crippa, M; Trendelenburg, M F; Scheer, Ulrich; Franke, Werner W

    2009-01-01

    Under the intluence of 5-tluoro-uridine, the ultrastructure of the rDNA transcription units in Xenopus oocytes is altered. Whereas part of the matrix units maintains anormal aspect or shows various degrees of inhibition, in a strong proportion of the transcription units the alternating pattern of matrix units and fibril-free spacer regions is no longer recognized. Transcriptional complexes are found along the entire DNP axis, including the regions of the spacers. These observations support bi...

  18. Produção de álcoois superiores por linhagens de Saccharomyces durante a fermentação alcoólica Production of higher alcohols by Saccharomyces strains during alcoholic fermentation

    Directory of Open Access Journals (Sweden)

    L.E. Gutierrez

    1993-12-01

    Full Text Available A produção de álcoois superiores pelas leveduras Saccharomyces cerevisiae M-300-A, Saccharomyces uvarum IZ-1904 e levedura de panificação (Saccharomyces cerevisiae foi estudada em diversas condições de temperatura, concentração de sacarose, pH, fontes de nitrogênio e com inibidor 2-4 dinitrofenol (DNP. Em todas as condições estudadas, a levedura Saccharomyces uvarum IZ-1904 apresentou a menor formação de álcoois superiores enquanto a levedura de panifícação apresentou os teores mais elevados. Com o aumento de temperatura e da concentração de sacarose ocorreu maior formação de álcool isoamílico pelas leveduras estudadas. Em pH 4,5 ocorreu menor produção de álcoois superiores do que em pH 3,0. Na presença do inibidor DNP ocorreu significativa redução (pThe production of higher alcohols by Saccharomyces cerevisiae M-300-A, Saccharomyces uvarum IZ-1904 and baker's yeast (5. cerevisiae was studied under several temperature conditions, sucrose level, pH, nitrogen sources and with 2-4 dinitrophenol (DNP. The yeast IZ-1904 showed lower production of higher alcohols than other yeasts in all conditions studied. With the increase of temperature and higher level of sucrose an increase of isoamyl alcohol production was observed. A lower formation of higher alcohols was observed at pH 4.5 than at pH 3.0. With the addition of DNP occurred a significant reduction in isoamyl alcohol content. The yeasts did not show the sanie production of higher alcohols in relation to urea and ammonium sulfate.

  19. Dynamic Nuclear Polarization as Kinetically Constrained Diffusion

    Science.gov (United States)

    Karabanov, A.; Wiśniewski, D.; Lesanovsky, I.; Köckenberger, W.

    2015-07-01

    Dynamic nuclear polarization (DNP) is a promising strategy for generating a significantly increased nonthermal spin polarization in nuclear magnetic resonance (NMR) and its applications that range from medicine diagnostics to material science. Being a genuine nonequilibrium effect, DNP circumvents the need for strong magnetic fields. However, despite intense research, a detailed theoretical understanding of the precise mechanism behind DNP is currently lacking. We address this issue by focusing on a simple instance of DNP—so-called solid effect DNP—which is formulated in terms of a quantum central spin model where a single electron is coupled to an ensemble of interacting nuclei. We show analytically that the nonequilibrium buildup of polarization heavily relies on a mechanism which can be interpreted as kinetically constrained diffusion. Beyond revealing this insight, our approach furthermore permits numerical studies of ensembles containing thousands of spins that are typically intractable when formulated in terms of a quantum master equation. We believe that this represents an important step forward in the quest of harnessing nonequilibrium many-body quantum physics for technological applications.

  20. Low-temperature dynamic nuclear polarization with helium-cooled samples and nitrogen-driven magic-angle spinning.

    Science.gov (United States)

    Thurber, Kent; Tycko, Robert

    2016-03-01

    We describe novel instrumentation for low-temperature solid state nuclear magnetic resonance (NMR) with dynamic nuclear polarization (DNP) and magic-angle spinning (MAS), focusing on aspects of this instrumentation that have not been described in detail in previous publications. We characterize the performance of an extended interaction oscillator (EIO) microwave source, operating near 264 GHz with 1.5 W output power, which we use in conjunction with a quasi-optical microwave polarizing system and a MAS NMR probe that employs liquid helium for sample cooling and nitrogen gas for sample spinning. Enhancement factors for cross-polarized (13)C NMR signals in the 100-200 range are demonstrated with DNP at 25K. The dependences of signal amplitudes on sample temperature, as well as microwave power, polarization, and frequency, are presented. We show that sample temperatures below 30K can be achieved with helium consumption rates below 1.3 l/h. To illustrate potential applications of this instrumentation in structural studies of biochemical systems, we compare results from low-temperature DNP experiments on a calmodulin-binding peptide in its free and bound states.