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Sample records for 207pb pri raspade

  1. Resonance capture cross section of 207Pb

    Domingo-Pardo, C; Aerts, G; Alvarez-Pol, H; Alvarez-Velarde, F; Andrzejewski, J; Andriamonje, Samuel A; Assimakopoulos, P A; Audouin, L; Badurek, G; Baumann, P; Becvar, F; Berthoumieux, E; Bisterzo, S; Calviño, F; Cano-Ott, D; Capote, R; Carrapico, C; Chepel, V; Cennini, P; Chiaveri, Enrico; Colonna, N; Cortés, G; Couture, A; Cox, J; Dahlfors, M; David, S; Dillman, I; Dolfini, R; Dridi, W; Durán, I; Eleftheriadis, C; Embid-Segura, M; Ferrant, L; Ferrari, A; Ferreira-Marques, R; Fitzpatrick, L; Frais-Kölbl, H; Fujii, K; Furman, W; Gallino, R; Gonçalves, I; González-Romero, E M; Goverdovski, A; Gramegna, F; Griesmayer, E; Guerrero, C; Gunsing, F; Haas, B; Haight, R; Heil, M; Herrera-Martínez, A; Igashira, M; Isaev, S; Jericha, E; Kadi, Y; Käppeler, F K; Karamanis, D; Karadimos, D; Kerveno, M; Ketlerov, V; Köhler, P; Konovalov, V; Kossionides, E; Krticka, M; Lamboudis, C; Leeb, H; Lindote, A; Lopes, I; Lozano, M; Lukic, S; Marganiec, J; Marrone, S; Mastinu, P; Mengoni, A; Milazzo, P M; Moreau, C; Mosconi, M; Neves, F; Oberhummer, Heinz; Oshima, M; O'Brien, S; Pancin, J; Papachristodoulou, C; Papadopoulos, C; Paradela, C; Patronis, N; Pavlik, A; Pavlopoulos, P; Perrot, L; Plag, R; Plompen, A; Plukis, A; Poch, A; Pretel, C; Quesada, J; Rauscher, T; Reifarth, R; Rosetti, M; Rubbia, Carlo; Rudolf, G; Rullhusen, P; Salgado, J; Sarchiapone, L; Savvidis, I; Stéphan, C; Tagliente, G; Taín, J L; Tassan-Got, L; Tavora, L; Terlizzi, R; Vannini, G; Vaz, P; Ventura, A; Villamarín, D; Vincente6, M C; Vlachoudis, V; Vlastou, R; Voss, F; Walter, S; Wendler, H; Wiescher, M; Wisshak, K

    2006-01-01

    The radiative neutron capture cross section of 207Pb has been measured at the CERN neutron time of flight installation n_TOF using the pulse height weighting technique in the resolved energy region. The measurement has been performed with an optimized setup of two C6D6 scintillation detectors, which allowed us to reduce scattered neutron backgrounds down to a negligible level. Resonance parameters and radiative kernels have been determined for 16 resonances by means of an R-matrix analysis in the neutron energy range from 3 keV to 320 keV. Good agreement with previous measurements was found at low neutron energies, whereas substantial discrepancies appear beyond 45 keV. With the present results, we obtain an s-process contribution of 77(8)% to the solar abundance of 207Pb. This corresponds to an r-process component of 23(8)%, which is important for deriving the U/Th ages of metal poor halo stars.

  2. NMR absolute shielding scale and nuclear magnetic dipole moment of (207)Pb.

    Adrjan, Bożena; Makulski, Włodzimierz; Jackowski, Karol; Demissie, Taye B; Ruud, Kenneth; Antušek, Andrej; Jaszuński, Michał

    2016-06-28

    An absolute shielding scale is proposed for (207)Pb nuclear magnetic resonance (NMR) spectroscopy. It is based on ab initio calculations performed on an isolated tetramethyllead Pb(CH3)4 molecule and the assignment of the experimental resonance frequency from the gas-phase NMR spectra of Pb(CH3)4, extrapolated to zero density of the buffer gas to obtain the result for an isolated molecule. The computed (207)Pb shielding constant is 10 790 ppm for the isolated molecule, leading to a shielding of 10799.7 ppm for liquid Pb(CH3)4 which is the accepted reference standard for (207)Pb NMR spectra. The new experimental and theoretical data are used to determine μ((207)Pb), the nuclear magnetic dipole moment of (207)Pb, by applying the standard relationship between NMR frequencies, shielding constants and nuclear moments of two nuclei in the same external magnetic field. Using the gas-phase (207)Pb and (reference) proton results and the theoretical value of the Pb shielding in Pb(CH3)4, we find μ((207)Pb) = 0.59064 μN. The analysis of new experimental and theoretical data obtained for the Pb(2+) ion in water solutions provides similar values of μ((207)Pb), in the range of 0.59000-0.59131 μN.

  3. Alpha-Decay of $^{211}Po$ on the 1633 keV $^{207}Pb$ level

    Chumin, V G; Malikov, Sh R; Norseev, Yu V; Samatov, Z K; Fominykh, V I; Cherevatenko, A P; Yurkova, L V

    2000-01-01

    In investigations of gamma-spectrum of ^{211}At and daughter ^{211}Po and ^{207}Bi isotopes a new branch of the alpha-decay on the ^{207}Pb 1633 keV level is discovered. Its intensity is 8.1 cdot 10^{-4} %.

  4. Interactions of 160 GeV/Nucleon $^{207}$Pb Nuclei in Emulsion Chambers with Copper and Lead Targets

    2002-01-01

    % EMU13 \\\\ \\\\ Nuclear emulsions will be used as targets and trackers to investigate the interactions of $^{207}$Pb nuclei in emulsion, copper and lead targets; specifically (i) the pseudorapidity distributions of charged particles including analysis of particle fluctuations in pseudorapidity and azimuthal angle distributions, (ii) the transverse momentum distribution of $\\alpha$ fragments from the projectile nucleus. \\\\ \\\\Several emulsion chambers with different geometry and targets will be exposed to the $^{207}$Pb beam. Each chamber will be irradiated with the beam of low density $^{207}$Pb ions (several hundred per cm$^2$). Interactions with small impact parameter, characterized by high multiplicity and disruption of the projectile nucleus will be found with high efficiency. Measurements in the emulsion will include the number and emission angles of charged particles produced and the emission angles of $\\alpha$ fragments from the projectile nucleus.

  5. Tree rings as Pb pollution archives? A comparison of 206Pb/207Pb isotope ratios in pine and other environmental media.

    Bindler, Richard; Renberg, Ingemar; Klaminder, Jonatan; Emteryd, Ove

    2004-02-05

    Tree rings, if validated as an environmental archive for pollution, would provide a convenient, geographically widespread archive for studying the temporal and spatial distribution of atmospheric pollutants. We collected tree-ring records from Scots pine (Pinus sylvestris L.), ranging in age from 100 to 300 years and from one spruce (Picea abies), from sites in southern and northern Sweden and analyzed their stable lead isotopic composition (206Pb/207Pb). These results are compared to the Pb isotopic composition in soil profiles from each of the sites and temporal changes in the 206Pb/207Pb ratio in peat and lake sediment deposits in Sweden. The mineral soils at each site are characterized by high 206Pb/207Pb ratios (> 1.35), while the ratios in the mor layer are low (1.14-1.16) and characterized by atmospheric lead pollution. The 206Pb/207Pb ratios of the tree rings, typically approximately 1.18-1.20, indicate a significant (10-30%) contribution of Pb derived from the underlying mineral soil. While peat and lake sediment records show that the 206Pb/207Pb ratio of atmospheric deposition has varied over time, with a pronounced trough between approximately 1930 and 1990, the tree rings show no similar trend. Further comparison of published Pb isotope data from other tree-ring records with time series from peat bogs and herbarium samples also shows poor agreement, and indicates that tree rings always contain a mixture of pollution Pb and Pb from the underlying mineral soil. The majority of Pb in the wood is derived from atmospheric pollution either directly, through aerial interception, or indirectly, through uptake from the large pool of accumulated pollution Pb in the soil. Since the Pb isotope ratios of the wood indicate that some natural Pb is taken up into the tree, then it must also be concluded that some fraction of the pollution Pb in the wood is likewise taken up from the forest soil. Based on the Pb isotope analyses, we can only conclude that dendrochemical

  6. Lead fluxes and 206Pb/207Pb isotope ratios in rime and snow collected at remote mountain-top locations (Czech Republic, Central Europe): Patterns and sources

    Cimova, Nikoleta; Novak, Martin; Chrastny, Vladislav; Curik, Jan; Veselovsky, Frantisek; Blaha, Vladimir; Prechova, Eva; Pasava, Jan; Houskova, Marie; Bohdalkova, Leona; Stepanova, Marketa; Mikova, Jitka; Krachler, Michael; Komarek, Arnost

    2016-10-01

    During three winter seasons (2009-2011), Pb concentrations were measured in precipitation at 10 high-elevation sites in the Czech Republic, close to the borders with Austria, Germany, Poland, and Slovakia. Soluble and insoluble Pb forms were quantified in snow (vertical deposition), and rime (horizontal deposition). The objective was to compare Pb input fluxes into ecosystems via vertical and horizontal deposition, and to identify the residual Pb pollution sources in an era of rapidly decreasing industrial pollution. Lead soluble in diluted HNO3 made up 96% of total Pb deposition, with the remaining 4% Pb bound mainly in silicates. Three times higher concentrations of soluble Pb in rime than in snow, and 2.5 times higher concentrations of insoluble Pb in rime than in snow were associated with slightly different Pb isotope ratios. On average, the 206Pb/207Pb ratios in rime were higher than those in snow. Higher mean 206Pb/207Pb ratios of insoluble Pb (1.175) than in soluble Pb (1.165) may indicate an increasing role of geogenic Pb in recent atmospheric deposition. A distinct reversal to more radiogenic 206Pb/207Pb ratios in snow and rime in 2010, compared to literature data from rain-fed Sphagnum peatlands (1800-2000 A.D.), documented a recent decrease in anthropogenic Pb in the atmosphere of Central Europe. Since the early 1980s, Pb concentrations in snow decreased 18 times in the rural south of the Czech Republic, but only twice in the industrial north of the Czech Republic. Isotope signatures indicated that Pb in today's atmospheric deposition is mainly derived from Mesozoic ores mined/processed in Poland and coal combustion in the Czech Republic and Poland.

  7. USVAJANJE JEZIKA PRI OTROCIH

    Kurmanšek, Urška

    2010-01-01

    Namen diplomske naloge je predstaviti usvajanje jezika pri otrocih, osnovne pogoje in stopnje le-tega in razložiti Chomskyijev pogled na jezikovno prirojenost in njegovo prepričanje, da učenje jezika ni nekaj, kar bi se otrok naučil, ampak da se mu enostavno zgodi na poti v razvoju v za to primernem socialnem okolju. Temu sledi razlaga Chomskyijeve in Skinnerjeve teorije o usvajanju jezika z namenom, da se poudarijo njuna različna pogleda na ta proces. Diplomska naloga je tako osredotočena na...

  8. Distribution of electron density in BaPb{sub 1-x}Bi{sub x}O{sub 3} evidenced by {sup 207}Pb and {sup 17}O NMR

    Trokiner, Arlette; Piskunov, Yuri; Gerashenko, Alexander; Pogudin, Anton; Mikhalev, Konstantin; Yakubovsky, Andrey; Verkhovskii, Stanislav

    2004-08-01

    The inhomogeneous magnetic broadening of the {sup 17}O and {sup 207}Pb NMR spectra resulting from a distribution of the Knight shifts was studied in the metallic phase of BaPb{sub 1-x}Bi{sub x}O{sub 3} oxides (0{<=}x{<=}0.33). It was shown that Bi atoms, which are randomly incorporated in the parent BaPbO{sub 3}, give rise to an increased spin density of carriers within the two first cation shells. The percolative overlap of these areas is expected for superconducting compositions (x>0.1)

  9. Measurement of the L/K electron capture ratio of the {sup 207}Bi decay to the 1633 keV level of {sup 207}Pb with a BGO scintillating bolometer

    Coron, N.; Gironnet, J.; Marcillac, P. de; Martinez, M.; Redon, T.; Torres, L. [Universite Paris-Sud 11 et CNRS (UMR 8617), Institut d' Astrophysique Spatiale, Orsay (France); Cuesta, C.; Garcia, E.; Ginestra, C.; Ortigoza, Y.; Pobes, C.; Puimedon, J.; Salinas, A.; Sarsa, M.L. [Universidad de Zaragoza, Grupo de Fisica Nuclear y Astroparticulas, Zaragoza (Spain); Watrin, A. [Universidad de Zaragoza, Grupo de Fisica Nuclear y Astroparticulas, Zaragoza (Spain); Universite Louis Pasteur, Ecole nationale superieure de physique de Strasbourg (ENSPS), Illkirch (France)

    2012-06-15

    The ROSEBUD Collaboration has dedicated several underground runs to study different types of bolometers, mainly for the search of dark matter. Some of these runs, profiting from the good energy resolution of one bolometer of BGO and the ultra-low background of the underground laboratory of Canfranc (LSC), allowed the measurement of the L/K electron capture ratio of the {sup 207}Bi decay to the 1633 keV level of {sup 207}Pb. This paper constitutes the first published measurement of this magnitude. (orig.)

  10. Remotely sensing the photochemical reflectance index, PRI

    Vanderbilt, Vern; Daughtry, Craig; Dahlgren, Robert

    2015-09-01

    In remote sensing, the Photochemical Reflectance Index (PRI) provides insight into physiological processes occurring inside leaves in a plant stand. Developed by1,2, PRI evolved from laboratory reflectance measurements of individual leaves. Yet in a remotely sensed image, a pixel measurement may include light from both reflecting and transmitting leaves. We compared values of PRI based upon polarized reflectance and transmittance measurements of water and nutrient stressed leaves. Our results show the polarized leaf surface reflection should be removed when calculating PRI and that the leaf physiology information is in leaf interior reflectance, not leaf transmittance.

  11. Procesi pri transportu kohezivnih sedimentov

    Pečovnik, Urška

    2015-01-01

    Pri procesih transporta, kot sta usedanje in privzdigovanje, obstajajo med kohezivnimi in nekohezivnimi sedimenti bistvene razlike. Obstoječi model PCFLOW3D ima v sedimentacijskem modulu vgrajene enačbe za nekohezivne sedimente, zato smo predpostavili, da na območjih kjer so sedimenti kohezivni, ne daje pravilnih rezultatov. Poiskali smo enačbe za račun usedanja, privzdigovanja in transporta kohezivnih sedimentov in jih primerjali z že vgrajenimi enačbami v modelu. Poiskali smo parametre, ki ...

  12. Linking Knowledge and Action: PRI's Community Consultant.

    Spencer, Gregory P.

    Within the Partnership for Rural Improvement (PRI), community consultants operate within three complex sets of relationships: client groups, the organizational structure of PRI, and the local operational base. Community consultants are responsible for developing and facilitating rural development and for providing assistance in community and…

  13. Stable (206Pb, 207Pb, 208Pb) and radioactive (210Pb) lead isotopes in 1 year of growth of Sphagnum moss from four ombrotrophic bogs in southern Germany: Geochemical significance and environmental implications

    Shotyk, William; Kempter, Heike; Krachler, Michael; Zaccone, Claudio

    2015-08-01

    The surfaces of Sphagnum carpets were marked with plastic mesh and 1 year later the production of plant matter was harvested in four ombrotrophic bogs from two regions of southern Germany: Upper Bavaria (Oberbayern, OB) and the Northern Black Forest (Nordschwarzwald, NBF). Radioactive, 210Pb was determined in solid samples using ultralow background gamma spectrometry while total Pb concentrations and stable isotopes (206Pb, 207Pb, 208Pb) were determined in acid digests using ICP-SMS. Up to 12 samples (40 × 40 cm) were collected per site, and 6-10 sites investigated per bog. The greatest variations within a given sampling site were in the range 212-532 Bq kg-1 for 210Pb activity, whereas 206Pb/207Pb and 208Pb/206Pb varied less than 1%. The median values of all parameters for the sites (6-10 per bog) were not significantly different. The median activities of 210Pb (Bq kg-1) in the mosses collected from the bogs in NBF (HO = 372 ± 56, n = 55; WI = 342 ± 58, n = 93) were slightly less from those in OB (GS = 394 ± 50, n = 55; KL = 425 ± 58, n = 24). However, the mosses in the NBF bogs exhibited much greater productivity (187-202 g m-2 a-1) compared to those of OB (71-91 g m-2 a-1), and this has a profound impact on the accumulation rates of 210Pb (Bq m-2 a-1), with the bogs in the NBF yielding fluxes (HO = 73 ± 30; WI = 65 ± 20) which are twice those of OB (GS = 29 ± 11; KL = 40 ± 13). Using the air concentrations of 210Pb measured at Schauinsland (SIL) in the southern Black Forest and average annual precipitation, the atmospheric fluxes of 210Pb at SIL (340 Bq m-2 a-1) exceeds the corresponding values obtained from the mosses by a factor of five, providing the first quantitative estimate of the net retention efficiency of 210Pb by Sphagnum. When the 210Pb activities of all moss samples are combined (n = 227), a significant decrease with increasing plant production rate is observed; in contrast, total Pb concentrations show the opposite trend. The contrasting

  14. Geochemistry and 207Pb/ 206Pb zircon ages of granitoids from the southern portion of the Tamboril-Santa Quitéria granitic-migmatitic complex, Ceará Central Domain, Borborema Province (NE Brazil)

    de Araujo, Carlos E. G.; Costa, Felipe G.; Pinéo, Tercyo R. G.; Cavalcante, José C.; Moura, Candido A. V.

    2012-02-01

    The Tamboril-Santa Quitéria Complex is an important Neoproterozoic granitic-migmatitic unit from the Ceará Central Domain that developed from ca. 650 to 610 Ma. In general the granitoids range in composition from diorite to granite with predominance (up to 85%) of granitic to monzogranitic composition with biotite as the main mafic AFM phase. Geochemical and 207Pb/ 206Pb evaporation zircon geochronology studies were applied in a group of these abundant monzogranitic rocks from the region of Novo Oriente in the southern portion of the Ceará Central Domain. In this area the granitoids are weakly peraluminous biotite granitoids and deformed biotite granitoids of high-K calc-alkaline and ferroan composition, which we interpreted as primary magmas (segregated diatexites) derived from the partial melting of crustal material. The close temporal relation of this magmatism with local eclogitic and regional high temperature metamorphism in Ceará Central Domain point out to an orogenic setting, arguably emplaced during the collisional stage. Subordinate coeval juvenile mantle incursions are also present. This crustally derived magmatism is the primary product of the continental thickening that resulted from the collision between the rocks represented by the Amazonian-West African craton (São Luiz cratonic fragment) to the northwest and the Paleoproterozoic-Archean basement of the Borborema Province to the southeast along the Transbrasiliano tectonic corridor.

  15. Electronic inhomogeneity and Ag:Sb imbalance of Ag1-yPb18/207Sb1+zTe20 high-performance thermoelectrics elucidated by 125Te and 207Pb NMR

    Levin, E.M.; Cook, B.A.; Ahn, K.; Kanatzidis, M.G.; Schmidt-Rohr, K.

    2009-09-22

    Using magic-angle spinning {sup 125}Te and {sup 207}Pb NMR, we have discovered the presence of two phases of approximately tenfold different free-electron concentration, n, in high-performance thermoelectrics Ag{sub 1?y}Pb{sub 18}Sb{sub 1+z}Te{sub 20} (LAST-18), proven by pairs of Knight-shifted NMR peaks and biexponential spin-lattice relaxation. The ratio of the phases is typically 2:1 with n {approx} 2 x 10{sup 19} cm{sup -3} and 0.2 x 10{sup 19} cm{sup -3}, respectively, determined from the spin-lattice relaxation times. {sup 125}Te NMR spectra show that both phases contain similar concentrations of Sb. The low-n component is assigned to Ag-rich regions with Ag-Sb pairing (but not AgSbTe{sub 2}), the dominant high-n component to PbTe:Sb resulting from the excess of Sb relative to Ag. The electronic inhomogeneity observed here must be considered in the search for a better understanding of high-performance thermoelectric materials.

  16. DnaT is a PriC-binding protein.

    Huang, Chien-Chih; Huang, Cheng-Yang

    2016-09-01

    DnaT and PriC are replication restart primosomal proteins required for re-initiating chromosomal DNA replication. DnaT is a component of the PriA-dependent primosome, while PriC belongs to the PriC-dependent primosome. Whether DnaT can interact with PriC is still unknown. In this study, we define a direct interaction between PriC, a key initiator protein in PriC-mediated DNA replication restart, and DnaT, a DnaB/C complex loader protein, from Klebsiella pneumoniae. In fluorescence titrations, PriC bound to single-stranded DNA with a binding-site size of approximately 9 nt. Gold nanoparticle assay showed that the solution of DnaT-PriC changed from red to purple, which indicated the protein-protein interactions due to gold nanoparticle aggregate. In addition, this DnaT-PriC complex could be co-purified by the heparin HP column. Surface plasmon resonance analysis showed that the Kd value of DnaT bound to PriC was 2.9 × 10(-8) M. These results constitute a pioneering study of the DnaT-PriC interaction and present a putative link between the two independent replication restart pathways, namely, PriA- and PriC-dependent primosome assemblies. Further research can directly focus on determining how DnaT binds to the PriC-SSB-DNA tricomplex and regulates the PriC-dependent replication restart.

  17. Presence of pRI1:

    Migura, Lourdes Garcia; Hasman, Henrik; Jensen, Lars Bogø

    2009-01-01

    This study focused on the molecular characterization of a small cryptic, mobilizable plasmid (6038 bp) sequenced from an E. faecium 9631160-1 of poultry origin. Sequence analysis of pRI1 revealed seven open reading frames. pRI1 contained an IS 100% identical to ISEfa4. This insertion element...... disrupted a putative mobilization gene (mobA) which presented 99% similarity to the one described in plasmid pJS42 (NC_010291). pRI1 harbored a cluster of four coding sequences which exhibited a homology to those described in contig 658 (from nucleotide 8940 to nt 10515) of E. faecium DO. In addition, a rep...... almost identical to the repA from the pEFNP1 and pKQ10 plasmids from E. faecium was also identified. Presence of the pRI1 replication initiation gene (rep) was analyzed in a panel of 159 E. faecium isolates of human and animal origin from different European countries, of which 60 tested positive...

  18. Remotely Sensing the Photochemical Reflectance Index (PRI)

    Vanderbilt, Vern

    2015-01-01

    In remote sensing, the Photochemical Reflectance Index (PRI) provides insight into physiological processes occurring inside the leaves in a stand of plants. Developed by Gamon et al., (1990 and 1992), PRI evolved from laboratory measurements of the reflectance of individual leaves (Bilger et al.,1989). Yet in a remotely sensed image, a pixel measurement may include light from both reflecting and transmitting leaves. We conducted laboratory experiments comparing values of PRI based upon polarized reflectance and transmittance measurements of water and nutrient stressed leaves. We illuminated single detached leaves using a current controlled light source (Oriel model 66881) and measured the leaf weight using an analytical balance (Mettler model AE 260) and the light reflected and transmitted by the leaf during dry down using two Analytical Spectral Devices spectroradiometers. Polarizers on the incident and reflected light beams allowed us to divide the leaf reflectance into two parts: a polarized surface reflectance and a non-polarized 'leaf interior' reflectance. Our results underscore the importance when calculating PRI of removing the leaf surface reflection, which contains no information about physiological processes ongoing in the leaf interior. The results show that the leaf physiology information is in the leaf interior reflectance, not the leaf transmittance. Applied to a plant stand, these results suggest use of polarization measurements in sun-view directions that minimize the number of sunlit transmitting leaves in the sensor field of view.

  19. Improved method for pulse sorting based on PRI transform

    Ren, Chunhui; Cao, Junqing; Fu, Yusheng; Barner, Kenneth E.

    2014-06-01

    To solve the problem of pulse sorting in complex electromagnetic environment, we propose an improved method for pulse sorting through in-depth analysis of the PRI transform algorithm principle and the advantages and disadvantages in this paper. The method is based on the traditional PRI transform algorithm, using spectral analysis of PRI transform spectrum to estimate the PRI centre value of jitter signal. Simulation results indicate that, the improved sorting method overcome the shortcomings of the traditional PRI jitter separation algorithm which cannot effectively sort jitter pulse sequence, in addition to the advantages of simple and accurate.

  20. Differential interference of vitamin D analogs PRI-1906, PRI-2191, and PRI-2205 with the renewal of human colon cancer cells refractory to treatment with 5-fluorouracil.

    Kotlarz, Agnieszka; Przybyszewska, Małgorzata; Swoboda, Paweł; Miłoszewska, Joanna; Grygorowicz, Monika Anna; Kutner, Andrzej; Markowicz, Sergiusz

    2016-04-01

    This study was aimed to determine whether hypocalcemic analogs of active forms of vitamins D modulate expression of genes related to stem-like phenotype in colon cancer cell lines HT-29 and HCT-116 undergoing renewal after the treatment with 5-fluorouracil (5-FU). Both lines express vitamin D receptor, but differ in differentiation stage and vitamin D sensitivity. Cells that resisted the 5-FU exposure were treated with synthetic analog of 1,25-dihydroxyvitamin D2 (PRI-1906) and analogs of 1,25-dihydroxyvitamin D3 (PRI-2191 and PRI-2205). Proliferative activity was more profoundly affected by vitamin D analogs in HT-29/5-FU than in HCT-116/5-FU cells. In HT-29/5-FU cells, analogs PRI-1906 and PRI-2191 downregulated the expression of genes related to survival, re-growth, and invasiveness during renewal, while PRI-2205 increased expression of genes related to differentiation only. In HCT-116/5-FU cells, PRI-2191 decreased the expression of stemness- and angiogenesis-related genes, whereas PRI-1906 augmented their expression. The effects in HCT-116/5-FU cells were observed at higher concentrations of the analogs than those used for HT-29/5-FU cells. Out of the series of analogs studied, PRI-2191 might be used to counteract the renewal of both moderately and poorly differentiated cancer cells following conventional treatment.

  1. Rb-Sr and single - zircon grain 207Pb / 206Pb chronology of the Monesterio granodiorite and related migmatites. Evidence of a Late Cambrian melting event in the Ossa-Morena Zone, Iberian Massif

    Bea, F.

    1999-04-01

    Full Text Available The Monesterio granodiorite, a small granodioritic body placed in a migmatitic complex in the SW of the Olivenza-Monesterio antiform, is a key plutonic body to understanding the relationships among the magmatism, metamorphism, and deformation in the Ossa-Morena Zone, SW Iberian Massif. We dated the granodiorite with the single zircon stepwise-evaporation 207Pb/206Pb method, and the related migmatization event with the Rb-Sr method on leucosomes. Our results indicate that the Monesterio granodiorite crystallised at 510 ± 7 Ma and its protolith had a component with Upper Proterozoic zircons with a minimum age of 1696 Ma. Leucosomes give a Rb-Sr age of 511 ± 40 Ma (MSWD =1,7 with initial 87Sr/86Sr =0.70914 ± 0.00048. The lower initial 87Sr/86Sr of the granodiorite and its calc-alkaline chemistry precludes it from having derived from the same protolith as the migmatites. The existence of different magmatic bodies in the Ossa-Morena Zone with ages clustering around 500-510 Ma reveals the existence of a significant melting event during the Late Cambrian that involved protoliths with very different geochemical and isotopic signatures.La granodiorita de Monesterio es un pequeño cuerpo emplazado en un complejo migmatítico en el SO del antiforme Olivenza-Monesterio, importante para entender las relaciones entre magmatismo, metamorfismo y deformación en la Zona de Ossa-Morena. Se ha datado la granodiorita por el método de evaporación secuencial de 207Pb/206Pb en cristal único de circón y los leucosomes de las migmatitas circundantes por el método Rb-Sr. Los datos indican una edad de cristalización de la granodiorita de 510 ± 4 Ma y un posible protolito Proterozoico Superior con una edad mínima de ∼1.700 Ma, obtenida a partir de núcleos heredados de los circones analizados. Los leucosomes dan una edad Rb-Sr de 511 ± 40 Ma, con una relación 87Sr/86Sr=0,70914 ± 0,00048. La relación inicial de 87Sr/86Sr en la granodiorita (

  2. Comment on "207Pb-206Pb single-zircon evaporation ages of some granitoid rocks reveal continent-oceanic island arc collision during the Cretaceous geodynamic evolution of the Central Anatolian crust, Turkey" - Boztug, D., Tichomirowa, M. & Bombach, K., 2007, JAES 31, 71-86

    Göncüoglu, M. Cemal

    A continent-oceanic island arc collision model was proposed as a new geodynamic scenario for the evolution of the Cretaceous Central Anatolian granitoids in the Central Anatolian crystalline complex (CACC) by Boztug et al. (2007b) [Boztug, D., Tichomirowa, M., Bombach, K., 2007b. 207Pb-206Pb single-zircon evaporation ages of some granitoid rocks reveal continent-oceanic island arc collision during the Cretaceous geodynamic evolution of the central Anatolian crust, Turkey. Journal of Asian Earth Sciences 31, 71-86]. The key aspects of this model include an intra-oceanic subduction in the Neotethyan Izmir-Ankara Ocean, formation of an island arc and its subsequent collision with the northern margin of the Tauride-Anatolide Platform. The identical scenario was initially proposed by Göncüoglu et al. (1992) [Göncüoglu, M.C., Erler, A., Toprak, V., Yalınız, K., Olgun, E., Rojay, B., 1992. Geology of the western Central Anatolian Massif, Part II: Central Areas. TPAO Report No: 3155, 76 p] . Moreover, the weighted mean values of the reported 207Pb-206Pb single-zircon evaporation ages by Boztug et al. (2007b) [Boztug, D., Tichomirowa, M., Bombach, K., 2007b. 207Pb-206Pb single-zircon evaporation ages of some granitoid rocks reveal continent-oceanic island arc collision during the Cretaceous geodynamic evolution of the central Anatolian crust: Turkey. Journal of Asian Earth Sciences 31, 71-86] from A-type granitoids in the CACC seem to be miscalculated and contrast with the field data.

  3. [Sensitivity study of a revised leaf photochemical reflectance index (PRI)].

    Wu, Chao-yang; Niu, Zheng; Tang, Quan

    2008-09-01

    Photochemical reflectance index (PRI) defined as a normalized difference index using two narrow reflectance bands at 531 and 570 nm that are closely related to xanthophyll cycle pigment content has been successfully used to estimate leaf photosynthetic light use efficiency (LUE) across species which vary in water content and nitrogen concentration. Previous research demonstrated that a consistent relationship could be established between PRI and LUE calculated from gas exchange measurements at the leaf, small canopy, and full forest or crop canopy scales. However, a number of problems, such as the saturation of PRI when LUE exceeds 0.03 mol CO2 mol(-1) PPED (photosynthetic photon flux density) and disjunctive relationships of PRI and LUE in seasonal changes, still existed and need to be handled in order to evaluate LUE more accurately. A sensitivity study of a revised PRI with four leaf parameters was performed based on PROSPECT model in the present article to study the effects of different biochemical concentrations on leaf SR-PRI (simple ratio PRI). Sensitivity study proved that leaf SR-PRI is more sensitive to leaf mesophyll structure parameter (N) and chlorophyll a + b content (c(ab)) than parameters of dry matter content (c(m)) and equivalent water thickness (c(w)), indicating that leaf mesophyll structure parameter (N) and chlorophyll a + b content (c(ab)) should be especially considered when acquiring leaf SR-PRI. And changes in the two parameters would cause large variation in SR-PRI which would reduce the precision for estimating light use efficiency. Validation study of SR-PRI was carried out in the analysis and the results proved that SR-PRI can also be a feasible index of estimating LUE for four species of plants with correlation coefficients better than that of PRI and LUE. The advantage of SR-PRI compared to PRI is its much clearer physical meaning and its sensitivity to the changes in reflectance at 531 nm which serves as a core parameter to evaluate

  4. Synthesis and Biological Activity of Diastereomeric and Geometric Analogs of Calcipotriol, PRI-2202 and PRI-2205, Against Human HL-60 Leukemia and MCF-7 Breast Cancer Cells.

    Milczarek, Magdalena; Chodyński, Michał; Filip-Psurska, Beata; Martowicz, Agnieszka; Krupa, Małgorzata; Krajewski, Krzysztof; Kutner, Andrzej; Wietrzyk, Joanna

    2013-10-31

    Diastereomeric and geometric analogs of calcipotriol, PRI-2202 and PRI-2205, were synthesized as advanced intermediates from vitamin D C-22 benzothiazoyl sulfones and side-chain aldehydes using our convergent strategy. Calcitriol, calcipotriol (PRI-2201) and tacalcitol (PRI-2191) were used as the reference compounds. Among a series of tested analogs the diastereomeric analog PRI-2202 showed the strongest antiproliferative activity on the human breast cancer cell line MCF-7, whereas the geometric analog PRI-2205 was the weakest. Both analogs were less potent in antiproliferative activity against HL-60 cells compared to the reference compounds. The ability to potentiate antiproliferative effect of cisplatin or doxorubicin against HL-60 cells or that of tamoxifen against the MCF-7 cell line was observed at higher doses of PRI-2202 or PRI-2205 than those of the reference compounds. The proapoptotic activity of tamoxifen, expressed as the diminished mitochondrial membrane potential, as well as the increased phosphatidylserine expression, was partially attenuated by calcitriol, PRI-2191, PRI-2201 and PRI-2205. The treatment of the MCF-7 cells with tamoxifen alone resulted in an increase in VDR expression. Moreover, a further increase in VDR expression was observed when the analogs PRI-2201 or PRI-2205, but not PRI-2191, were used in combination with tamoxifen. This observation could partially explain the potentiation of the antiproliferative effect of tamoxifen by vitamin D analogs.

  5. U/Pb (SHRIMP), {sup 207}Pb/{sup 206}Pb, Rb/Sr, Sm/Nd e K/Ar geochronology of granite-greenstone terrains of Gaviao Block: implications for the Proterozoic and Archean evolution of Sao Francisco Craton, Brazil; Geocronologia U/Pb (SHRIMP), {sup 207}Pb/{sup 206}Pb, Rb/Sr, Sm/Nd e K/Ar dos terrenos granito-greenstone do Bloco do Gaviao: implicacoes para a evolucao arqueana e proterozoica do craton do Sao Francisco, Brasil

    Leal, Luiz Rogerio Bastos

    1998-07-01

    The Gaviao Block (GB) in the northern portion of the Sao Francisco Craton-Northeast of Brazil, constitutes one of the oldest Archean fragments of the South American Platform Archean crust. GB underwent several events of juvenile accretion and reworking of continental crust along its evolutionary history, notably between the Archean and the Paleoproterozoic. {sup 207}Pb/{sup 206}Pb isotopic analyses were carried out in two zircons populations from strongly migmatized TTG terranes found in the proximity of Brumado: the first population (7 crystals) is taken as representative of the crystallization period of the TTG terranes at 3300 {+-} 45 Ma; the second (2 crystals) represents the age of the first even of metamorphism/migmatization at 2910 {+-} 10 Ma. {sup 207} Pb/{sup 206} Pb analyses in zircons from an outcrop of non-migmatized TTG in the area yielded a 3202 {+-} 15 Ma age (4 crystals), interpreted to be the crystallization period of the gneiss protolith. Sm/Nd analyses on the TTG rocks of the Brumado region yielded T{sub DM} model ages varying between 3.26 and 3.36 Ga and {epsilon}{sub Nd}{sup (t)} between -3.5 and +0.7. These data suggest the occurrence of juvenile accretions to the continental crust during the Archean, with differential involvement of crustal materials. The geochemical data of rare earth elements corresponding to the TTG terranes revealed moderate LRRE contents (La{sub N}=83,5), low HREE contents (La{sub N}=2,5) and a fairly fractionated pattern (La/Yb){sub N}=34, besides lack of negative Eu anomaly, showing that these rocks have similar compositions to those TTG terranes of cratonic continents, as well as some Archean rocks from CSF (e.g. Sete Voltas, Boa Vista). Finally, the youngest ages present in GB rocks (ca. 1.2-0.45 Ga) represent the role played by tectono thermal events, which produced partial or total rejuvenation of the Rb/Sr and K/Ar isotopic systems during the Espinhaco and Brasiliano cycles. In particular, K/Ar ages illustrate the

  6. PRI: An Periodically Receiver-Initiated Task Scheduling Algorithm

    2000-01-01

    Task scheduling is a key problem for the distributed computation. This thesis analyzes receiver-initiated(RI) task scheduling algorithm, finds its weakness and presents an improved algorithm-PRI algorithm. This algorithm schedules the concurrent tasks onto network of workstation dynamically at runtime, and initiates task scheduling by the node of low load. The threshold on each node can be modified according to the system information which is periodically detected. Meanwhile, the detecting period can be adjusted in terms of the change of the system state. The result of the experiments shows that the PRI algorithm is superior to the RI algorithm.

  7. VPLIV IZVORA NADZOROVANJA NA NEKATERE DEJAVNIKE PRI DELU REVIZORJEV

    Voje, Melita

    2012-01-01

    Izvor nadzorovanja (angl. Locus of Control) je psihološki pojem, ki ločuje posameznike na tiste s poudarjenim notranjim izvorom nadzorovanja – internaliste, in tiste s poudarjenim zunanjim izvorom nadzorovanja – eksternaliste. Razlika med njimi je v prepričanju, da kar se jim v življenju dogaja, je pri enih posledica njihovega lastnega napora, vloženega znanja, truda, pri drugih pa posledica sreče, usode. V drugem delu naloge smo opredelili pojem izvora nadzorovanja ter način ugotavljanja...

  8. Geology of Planina pri Jezeru and its environs (Slovenia

    Mihael Brenčič

    2008-06-01

    Full Text Available The article describes the results of detailed geological mapping of the wider environs of Planina pri Jezeru north of Bohinj. In the literature the Upper Triassic massive and bedded limestone, Jurassic limestone, Cretaceous clastic rocks and Pleistocene sediments have been reported in this area up to now. The article supplements existing lithostratigraphic information by defining exact locations of the Pleistocene sediments at Planina pri Jezeru and Planina v Lazu, and of Jurassic rocks. In Poljane a Neptunian dyke and bioclastic limestone, while north of Mizčna glava a flat-bedded microsparitic limestone were described for the first time.Correlation to the Triglav Lakes Valley Jurassic beds indicates equivalent facieses. Allochthon Cretaceous biocalcarenite and jasper situated east of Planina pri Jezeru are also described due to their importance for further glaciological studies. The results show that the recent lake Jezero na Planini pri Jezeru is formed due to the accumulation of Pleistocene glacial-lacustrine fine-grained sediment in till,deposited on the Dachstein limestone.

  9. Canopy Level Chlorophyll Fluorescence and the PRI in a Cornfield

    Middleton, Elizabeth M.; Cheng, Yen-Ben; Corp, Lawrence A.; Campbell, Petya K. E.; Huemmrich, K. Fred; Zhang, Qingyuan; Kustas, William P.

    2012-01-01

    Two bio-indicators, the Photochemical Reflectance Index (PRI) and solar-induced red and far-red Chlorophyll Fluorescence (SIF), were derived from directional hyperspectral observations and studied in a cornfield on two contrasting days in the growing season. Both red and far-red SIF exhibited higher values on the day when the canopy in the early senescent stage, but only the far-red SIF showed sensitivity to viewing geometry. Consequently, the red/far-red SIF ratio varied greatly among azimuth positions while the largest values were obtained for the "hotspot" at both growth stages. This ratio was lower (approx.0.88 +/- 0.4) in early July than in August when the ratio approached equivalence (near approx.1). In concert, the PRI exhibited stronger responses to both zenith and azimuth angles and different values on the two growth stages. The potential of using these indices to monitor photosynthetic activities needs further investigation

  10. The Primitive Material Explorer (PriME) Mission

    Cochran, Anita L.; Weaver, H. A.; Science, PriME; Engineering Teams

    2010-10-01

    The Primitive Material Explorer (PriME) Mission is a proposed Discovery mission that will rendezvous with comet 46P/Wirtanen in 2021 in order to 1) clarify the roles played by comets in the formation and evolution of the Solar System and the origin of life; 2) ascertain the bulk physical properties, the surface geology, and the sources of activity in a fresh comet nucleus; and 3) investigate the compositional diversity of primitive material in the Solar System. PriME teams an experienced group of comet scientists (led by PI Anita Cochran and by DPI Harold Weaver) with university and industrial partners. The PriME payload accomplishes the mission objectives with only three instruments. MASPEX (MAss Spectrometer for Planetary EXploration) has higher mass resolution and is more sensitive than any mass spectrometer ever flown. MASPEX will measure D/H in H2O, noble gases, isotopes of many species, and complex molecular compounds to test solar nebula models and the role comets played in delivering water and other biologically important materials throughout the Solar System. The VIS (Visible Imaging System), consisting of a Narrow Angle Camera (NAC) and Wide-Angle Camera (WAC), will constrain the conditions under which the building blocks of the outer Solar System were assembled by measuring key physical properties of the nucleus of 46P/Wirtanen. Using the radio antenna and close flybys of the nucleus, PriME will determine the mass of the nucleus to an accuracy of 1% and the bulk density and average porosity of the nucleus to better than 5%. All spacecraft subsystems have significant planetary flight heritage. The spacecraft is a high-heritage derivative of the Kepler and Deep Impact spacecrafts, compatible with the three launch vehicle families specified in the Discovery Announcement of Opportunity.

  11. Prodifferentiation Activity of Novel Vitamin D₂ Analogs PRI-1916 and PRI-1917 and Their Combinations with a Plant Polyphenol in Acute Myeloid Leukemia Cells.

    Nachliely, Matan; Sharony, Ehud; Bolla, Narasimha Rao; Kutner, Andrzej; Danilenko, Michael

    2016-07-05

    1α,25-dihydroxyvitamin D₃ (1,25D3) is a powerful differentiation inducer for acute myeloid leukemia (AML) cells. However, 1,25D3 doses required for differentiation of AML cells may cause lethal hypercalcemia in vivo. There is evidence that vitamin D₂ is less toxic than vitamin D₃ in animals. Here, we determined the differentiation effects of novel analogs of 1α,25-dihydroxyvitamin D₂ (1,25D2), PRI-1916 and PRI-1917, in which the extended side chains of their previously reported precursors (PRI-1906 and PRI-1907, respectively) underwent further 24Z (24-cis) modification. Using four human AML cell lines representing different stages of myeloid maturation (KG-1a, HL60, U937, and MOLM-13), we found that the potency of PRI-1916 was slightly higher or equal to that of PRI-1906 while PRI-1917 was significantly less potent than PRI-1907. We also demonstrated that 1,25D2 was a less effective differentiation agent than 1,25D3 in these cell lines. Irrespective of their differentiation potency, all the vitamin D₂ derivatives tested were less potent than 1,25D3 in transactivating the DR3-type vitamin D response elements. However, similar to 1,25D3, both 1,25D2 and its analogs could strongly cooperate with the plant polyphenol carnosic acid in inducing cell differentiation and inhibition of G1-S cell cycle transition. These results indicate that the 24Z modification has contrasting effects on the differentiation ability of PRI-1906 and PRI-1907 and that the addition of a plant polyphenol could result in a similar extent of cell differentiation induced by different vitamin D compounds. The enhanced antileukemic effects of the tested combinations may constitute the basis for the development of novel approaches for differentiation therapy of AML.

  12. Prodifferentiation Activity of Novel Vitamin D2 Analogs PRI-1916 and PRI-1917 and Their Combinations with a Plant Polyphenol in Acute Myeloid Leukemia Cells

    Matan Nachliely

    2016-07-01

    Full Text Available 1α,25-dihydroxyvitamin D3 (1,25D3 is a powerful differentiation inducer for acute myeloid leukemia (AML cells. However, 1,25D3 doses required for differentiation of AML cells may cause lethal hypercalcemia in vivo. There is evidence that vitamin D2 is less toxic than vitamin D3 in animals. Here, we determined the differentiation effects of novel analogs of 1α,25-dihydroxyvitamin D2 (1,25D2, PRI-1916 and PRI-1917, in which the extended side chains of their previously reported precursors (PRI-1906 and PRI-1907, respectively underwent further 24Z (24-cis modification. Using four human AML cell lines representing different stages of myeloid maturation (KG-1a, HL60, U937, and MOLM-13, we found that the potency of PRI-1916 was slightly higher or equal to that of PRI-1906 while PRI-1917 was significantly less potent than PRI-1907. We also demonstrated that 1,25D2 was a less effective differentiation agent than 1,25D3 in these cell lines. Irrespective of their differentiation potency, all the vitamin D2 derivatives tested were less potent than 1,25D3 in transactivating the DR3-type vitamin D response elements. However, similar to 1,25D3, both 1,25D2 and its analogs could strongly cooperate with the plant polyphenol carnosic acid in inducing cell differentiation and inhibition of G1–S cell cycle transition. These results indicate that the 24Z modification has contrasting effects on the differentiation ability of PRI-1906 and PRI-1907 and that the addition of a plant polyphenol could result in a similar extent of cell differentiation induced by different vitamin D compounds. The enhanced antileukemic effects of the tested combinations may constitute the basis for the development of novel approaches for differentiation therapy of AML.

  13. Relationships between the photochemical reflectance index (PRI) and chlorophyll fluorescence parameters and plant pigment indices at different leaf growth stages.

    Rahimzadeh-Bajgiran, Parinaz; Munehiro, Masashi; Omasa, Kenji

    2012-09-01

    This study aimed to evaluate the photochemical reflectance index (PRI) for assessing plant photosynthetic performance throughout the plant life cycle. The relationships between PRI, chlorophyll fluorescence parameters, and leaf pigment indices in Solanum melongena L. (aubergine; eggplant) were studied using photosynthetic induction curves both in short-term (diurnal) and long-term (seasonal) periods under different light intensities. We found good correlations between PRI/non-photochemical quenching (NPQ) and PRI/electron transport rate (ETR) in the short term at the same site of a single leaf but these relationships did not hold throughout the life of the plant. In general, changes in PRI owing to NPQ or ETR variations in the short term were PRI was highly correlated to plant pigments, especially chlorophyll indices measured by spectral reflectance. Moreover, relationships of steady-state PRI/ETR and steady-state PRI/photochemical yield of photosystem II (Φ(PSII)) measured at uniform light intensity at different life stages proved that overall photosynthesis capacity and steady-state PRI were better correlated through chlorophyll content than NPQ and xanthophylls. The calibrated PRI index accommodated these pigments effects and gave better correlation with NPQ and ETR than PRI. Further studies of PRI indices based on pigments other than xanthophylls, and studies on PRI mechanisms in different species are recommended.

  14. Analiza toplotnih izgub pri različnih okenskih sistemih

    Movrin, Miran

    2014-01-01

    Ob vseobsegajočih razvojnih trendih tudi okna niso bila izvzeta, njihov razvoj je med drugim šel tudi v smeri zmanjševanja toplotnih izgub. Raziskovali smo, kolikšne so toplotne izgube pri okenskih sistemih z različno okvirno konstrukcijo, s steklom in z distančno letvijo. Ugotovili smo, da imajo lesena, aluminijasta in PVC-okna z novimi PVC-distančniki manjše toplotne izgube od dosedanjih izdelanih s klasičnimi, aluminijastimi distančniki. Ugotovitev pa je tudi razultat primerjave velikosti ...

  15. Pomen čustvene inteligentnosti pri vodenju v zdravstveni negi

    Meško, Janja

    2011-01-01

    Diplomsko delo z naslovom pomen čustvene inteligentnosti pri vodenju v zdravstveni negi je teoretično. S pomočjo deskriptivne metode dela in študija različne literature smo predstavili pomen čustvene inteligentnosti, vodenja in predvsem povezavo obeh pojmov v zdravstveni negi. Dandanes je čustvena inteligentnost vedno bolj v ospredju ter vedno bolj središče zanimanja, saj so časi, v katerem so bila čustva označena kot nekaj, kar za posel ni pomembno, minili. Pregledali smo domačo in tujo lite...

  16. VEDENJE SLOVENSKIH POTROŠNIKOV PRI SPLETNEM NAKUPOVANJU

    Kos, Jasmina

    2015-01-01

    Težko bi rekli, da bo spletno nakupovanje izpodrinilo klasično nakupovanje v fizičnih trgovinah in trgovskih centrih, vendar pa kljub temu lahko rečemo, da pričakujemo v naslednjih letih na spletu še več trgovin in povečano rast spletnih potrošnikov. Spletne trgovine imajo namreč mnogo prednosti, saj lahko udobno iz naslonjača kadarkoli in kjerkoli (dokler imamo internetno povezavo) kupimo izdelek, ki ga želimo, brez vsiljevanja prodajalčevega mnenja, čakanja na blagajni, iskanja parkirnega p...

  17. POMEN VAROVANJA INTELEKTUALNE LASTNINE PRI SNOVANJU POLITIKE PODJETJA

    Budja, Matej

    2014-01-01

    V diplomskem seminarju sem ugotavljal medsebojno soodvisnost politike podjetja in pomena varovanja intelektualne lastnine. Osredotočil sem se na inovativno slovensko podjetje Eurel d.o.o., katerega vodi Štefan Kuzma, teoretični in praktični strokovnjak tako pri vodenju podjetja, kot tudi v zvezi z varovanjem IL. Ugotovil sem sledeče: • Eurel proizvaja izdelke skladno z zahtevanimi specifikacijami naročnikov in v dogovorjenih rokih • Zadovoljnost odjemalcev je njihova prioriteta • ...

  18. Three causes of variation in the photochemical reflectance index (PRI) in evergreen conifers.

    Wong, Christopher Y S; Gamon, John A

    2015-04-01

    The photochemical reflectance index (PRI) reflects diurnal xanthophyll cycle activity and is also influenced by seasonally changing carotenoid : Chl pigment ratios. Both changing pigment pools and xanthophyll cycle activity contribute to photoprotection in evergreen conifers exposed to boreal winters, but they operate over different timescales, and their relative contribution to the PRI signal has often been unclear. To clarify these responses and their contribution to the PRI signal, leaf PRI, pigment composition, temperature and irradiance were monitored over 2 yr for two evergreen conifers (Pinus contorta and Pinus ponderosa) in a boreal climate. PRI was affected by three distinct processes operating over different timescales and exhibiting contrasting spectral responses. Over the 2 yr study period, the greatest change in PRI resulted from seasonally changing carotenoid : Chl pigment ratios, followed by a previously unreported shifting leaf albedo during periods of deep cold. Remarkably, the smallest change was attributable to the xanthophyll cycle. To properly distinguish these three effects, interpretation of PRI must consider temporal context, physiological responses to evolving environmental conditions, and spectral response. Consideration of the separate mechanisms affecting PRI over different timescales could greatly improve efforts to monitor changing photosynthetic activity using optical remote sensing.

  19. Draft genome sequence of the antagonistic rhizosphere bacterium Serratia plymuthica strain PRI-2C.

    Garbeva, P; van Elsas, J D; de Boer, W

    2012-08-01

    Serratia plymuthica strain PRI-2C is a rhizosphere bacterial strain with antagonistic activity against different plant pathogens. Here we present the 5.39-Mb (G+C content, 55.67%) draft genome sequence of S. plymuthica strain PRI-2C with the aim of providing insight into the genomic basis of its antagonistic activity.

  20. PRI Play Important Role in West-East Project · Interview with PIR Director Xue Zhenkui

    Xiao Lu

    2002-01-01

    @@ Pipeline Research Institute of CNPC (PRI) is playing a more and more important role in the oil and natural gas pipeline industrial development in the present-day China. The pipeline technology and equipment developed by PRI have proven costeffective and extremely useful in the country's WestEast gas transmission pipeline project

  1. Partnership for Rural Improvement: PRI in Transition. Annual Report 1979-80.

    Hagood, Richard A.; And Others

    Covering 1979-80, which was the final year of the initial four year grant period for the Partnership for Rural Improvement (PRI), this report details the major assessments and program adjustments made during that year. Several program developments of critical importance to understanding the transition occurring in PRI are highlighted in the…

  2. Diffuse sky radiation influences the relationship between canopy PRI and shadow fraction

    Mõttus, Matti; Takala, Tuure L. H.; Stenberg, Pauline; Knyazikhin, Yuri; Yang, Bin; Nilson, Tiit

    2015-07-01

    The Photochemical Reflectance Index (PRI) of green leaves is an indicator of photosynthetic downregulation: when the photosynthetic apparatus is close to the saturation limit, PRI becomes dependent on light conditions. Therefore, by measuring the PRI of leaves under different local irradiance conditions, it should be possible to determine the saturation level of the leaves and obtain information on the light use efficiency (LUE) of a vegetation canopy. The dependence of PRI on the ratio of sunlit to shaded foliage (quantified by the canopy shadow fraction) in the field of view of an instrument has been used to remotely measure canopy LUE on clear days. However, besides photosynthetic downregulation, the dependence of canopy PRI on shadow fraction is affected by the blue sky radiation caused by scattering in the atmosphere. To quantify this effect on remotely sensed PRI, we present the underlying definitions relating leaf and canopy PRI and perform the required calculations for typical midsummer conditions in Central Finland. We demonstrate that the effect of blue sky radiation on the variation of PRI with canopy shadow fraction is similar in shape and magnitude to that of LUE variations reported in literature.

  3. Evidence for a cytoplasmic microprocessor of pri-miRNAs.

    Shapiro, Jillian S; Langlois, Ryan A; Pham, Alissa M; Tenoever, Benjamin R

    2012-07-01

    microRNAs (miRNAs) represent a class of noncoding RNAs that fine-tune gene expression through post-transcriptional silencing. While miRNA biogenesis occurs in a stepwise fashion, initiated by the nuclear microprocessor, rare noncanonical miRNAs have also been identified. Here we characterize the molecular components and unique attributes associated with the processing of virus-derived cytoplasmic primary miRNAs (c-pri-miRNAs). RNA in situ hybridization and inhibition of cellular division demonstrated a complete lack of nuclear involvement in c-pri-miRNA cleavage while genetic studies revealed that maturation still relied on the canonical nuclear RNase III enzyme, Drosha. The involvement of Drosha was mediated by a dramatic relocalization to the cytoplasm following virus infection. Deep sequencing analyses revealed that the cytoplasmic localization of Drosha does not impact the endogenous miRNA landscape during infection, despite allowing for robust synthesis of virus-derived miRNAs in the cytoplasm. Taken together, this research describes a unique function for Drosha in the processing of highly structured cytoplasmic RNAs in the context of virus infection.

  4. PriC-mediated DNA replication restart requires PriC complex formation with the single-stranded DNA-binding protein.

    Wessel, Sarah R; Marceau, Aimee H; Massoni, Shawn C; Zhou, Ruobo; Ha, Taekjip; Sandler, Steven J; Keck, James L

    2013-06-14

    Frequent collisions between cellular DNA replication complexes (replisomes) and obstacles such as damaged DNA or frozen protein complexes make DNA replication fork progression surprisingly sporadic. These collisions can lead to the ejection of replisomes prior to completion of replication, which, if left unrepaired, results in bacterial cell death. As such, bacteria have evolved DNA replication restart mechanisms that function to reload replisomes onto abandoned DNA replication forks. Here, we define a direct interaction between PriC, a key Escherichia coli DNA replication restart protein, and the single-stranded DNA-binding protein (SSB), a protein that is ubiquitously associated with DNA replication forks. PriC/SSB complex formation requires evolutionarily conserved residues from both proteins, including a pair of Arg residues from PriC and the C terminus of SSB. In vitro, disruption of the PriC/SSB interface by sequence changes in either protein blocks the first step of DNA replication restart, reloading of the replicative DnaB helicase onto an abandoned replication fork. Consistent with the critical role of PriC/SSB complex formation in DNA replication restart, PriC variants that cannot bind SSB are non-functional in vivo. Single-molecule experiments demonstrate that PriC binding to SSB alters SSB/DNA complexes, exposing single-stranded DNA and creating a platform for other proteins to bind. These data lead to a model in which PriC interaction with SSB remodels SSB/DNA structures at abandoned DNA replication forks to create a DNA structure that is competent for DnaB loading.

  5. New insights into pri-miRNA processing and accumulation in plants.

    Zhang, Shuxin; Liu, Yuhui; Yu, Bin

    2015-01-01

    MicroRNAs (miRNAs) regulate many biological processes such as development, metabolism, and others. They are processed from their primary transcripts called primary miRNA transcripts (pri-miRNAs) by the processor complex containing the RNAse III enzyme, DICER-LIKE1 (DCL1), in plants. Consequently, miRNA biogenesis is controlled through altering pri-miRNA accumulation and processing, which is crucial for plant development and adaptation to environmental changes. Plant pri-miRNAs are transcribed by DNA-dependent RNA polymerase II (Pol II) and their levels are determined through transcription and degradation, whereas pri-miRNA processing is affected by its structure, splicing, alternative splicing, loading to the processor and the processor activity, which involve in many accessory proteins. Here, we summarize recent progresses related to pri-miRNA transcription, stability, and processing in plants.

  6. Correcting the relationship between PRI and shadow fraction for the blue sky effect

    Mõttus, Matti

    2016-04-01

    The Photochemical Reflectance Index (PRI) is defined as the normalized difference ratio of leaf reflectance at two specific wavelengths in the green spectral region. Its value depends on the status of leaf carotenoid content, and especially that of the xanthophyll cycle pigments. Due to the dependence on the xanthophyll cycle, when the photosynthetic apparatus of green leaves is close to the saturation limit, their PRI becomes dependent on light conditions. Therefore, by measuring the PRI of leaves in the same canopy under different local irradiance conditions on a sunny day, it should be possible to determine the saturation level of the leaves. In turn, this gives information on the light use efficiency (LUE) of the vegetation canopy. The average light conditions of visible foliage elements are often quantified with the shadow fraction -- the fraction of visible foliage not lit by direct sunlight. The dependence of PRI on the shadow fraction has been used to remotely measure canopy LUE on clear days. Variations in shadow fraction have been achieved with multiangular measurement. However, besides photosynthetic downregulation, the dependence of canopy PRI on shadow fraction is affected by the blue sky radiation caused by scattering in the atmosphere. To quantify this effect on remotely sensed PRI, we present the underlying definitions relating leaf and canopy PRI and perform the required calculations for typical midsummer conditions in Central Finland. We demonstrate that the effect of blue sky radiation on the variation of PRI with canopy shadow fraction is similar in shape and magnitude to that of LUE variations reported in literature. Next, we propose a new method to assess these PRI variations in structured vegetation. We investiagate this blue sky effect on the PRI -- shadow fraction relationship with high spatial (60 cm) and spectral (9.8 nm) resolution airborne imaging spectroscopy data from Hyytiälä, Finland. We evaluate the spectral irradiance in

  7. Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing.

    Auyeung, Vincent C; Ulitsky, Igor; McGeary, Sean E; Bartel, David P

    2013-02-14

    To use microRNAs to downregulate mRNA targets, cells must first process these ~22 nt RNAs from primary transcripts (pri-miRNAs). These transcripts form RNA hairpins important for processing, but additional determinants must distinguish pri-miRNAs from the many other hairpin-containing transcripts expressed in each cell. Illustrating the complexity of this recognition, we show that most Caenorhabditis elegans pri-miRNAs lack determinants required for processing in human cells. To find these determinants, we generated many variants of four human pri-miRNAs, sequenced millions that retained function, and compared them with the starting variants. Our results confirmed the importance of pairing in the stem and revealed three primary-sequence determinants, including an SRp20-binding motif (CNNC) found downstream of most pri-miRNA hairpins in bilaterian animals, but not in nematodes. Adding this and other determinants to C. elegans pri-miRNAs imparted efficient processing in human cells, thereby confirming the importance of primary-sequence determinants for distinguishing pri-miRNAs from other hairpin-containing transcripts.

  8. Monitoring seasonal and diurnal changes in photosynthetic pigments with automated PRI and NDVI sensors

    Gamon, J. A.; Kovalchuck, O.; Wong, C. Y. S.; Harris, A.; Garrity, S. R.

    2015-07-01

    The vegetation indices normalized difference vegetation index (NDVI) and photochemical reflectance index (PRI) provide indicators of pigmentation and photosynthetic activity that can be used to model photosynthesis from remote sensing with the light-use-efficiency model. To help develop and validate this approach, reliable proximal NDVI and PRI sensors have been needed. We tested new NDVI and PRI sensors, "spectral reflectance sensors" (SRS sensors; recently developed by Decagon Devices, during spring activation of photosynthetic activity in evergreen and deciduous stands. We also evaluated two methods of sensor cross-calibration - one that considered sky conditions (cloud cover) at midday only, and another that also considered diurnal sun angle effects. Cross-calibration clearly affected sensor agreement with independent measurements, with the best method dependent upon the study aim and time frame (seasonal vs. diurnal). The seasonal patterns of NDVI and PRI differed for evergreen and deciduous species, demonstrating the complementary nature of these two indices. Over the spring season, PRI was most strongly influenced by changing chlorophyll : carotenoid pool sizes, while over the diurnal timescale, PRI was most affected by the xanthophyll cycle epoxidation state. This finding demonstrates that the SRS PRI sensors can resolve different processes affecting PRI over different timescales. The advent of small, inexpensive, automated PRI and NDVI sensors offers new ways to explore environmental and physiological constraints on photosynthesis, and may be particularly well suited for use at flux tower sites. Wider application of automated sensors could lead to improved integration of flux and remote sensing approaches for studying photosynthetic carbon uptake, and could help define the concept of contrasting vegetation optical types.

  9. RAČUNOVODSKE INFORMACIJE PRI UPRAVLJANJU ČLOVEŠKIH VIROV V PODJETJU X

    2012-01-01

    V diplomski nalogi je predstavljeno upravljanje človeških virov in računovodske informacije o le teh. Opredelili smo informacije nasploh in računovodske informacije, ki jih potrebujemo pri odločitvah o človeških virih. Od vsakega podjetja je odvisno ali bo pri različnih nalogah upravljanja človeških virov uporabil računovodske informacije. Pri vseh nalogah upravljanja človeških virov so uporabne računovodske informacije, odvisno od velikosti in razširjenosti upravljanja človeških virov v...

  10. Prying Force Calculation and Design Method for T-shaped Tensile Connector with High Strength Bolt

    Zhaoxin Hou; Guohong Huang; Chao Gong

    2015-01-01

    In order to establish the design method for T⁃shaped tensile connector with high strength bolt, the theoretical analysis is carried out. Firstly, it analyzes the performance of the connector and establishes prying force calculation model. Based on the model, prying force equation and function between bolt prying force and flange thickness is derived, and the min and max thickness requirement of flange plate under a certain tension load is then obtained. Finally, two simplified design methods of the connector are proposed, which are bolt pulling capacity method and flange plate bending capacity method.

  11. Odzivi učencev na didaktične igre pri obravnavi gibanja pri predmetu Spoznavanje okolja

    Novak, Ines

    2016-01-01

    Igra pri pouku je priporočljiva dejavnost predvsem z vidika učencev, saj spodbuja zanimanje in vse vrste motivacije. Učenci skozi igro projicirajo svoje primanjkljaje in jih na ta način lažje premagujejo. Ni dovolj, da se učenci v šoli zgolj učijo, ampak naj bi se tam tudi dobro počutili, kar pripomore k boljšemu spremljanju pouka in trajnejšemu znanju. V teoretičnem delu magistrskega dela predstavimo kognitivni, čustveni in socialni razvoj otroka, razvoj otroške igre ter vlogo didaktične igr...

  12. Regulation of pri-miRNA processing by the hnRNP-like protein AtGRP7 in Arabidopsis.

    Köster, Tino; Meyer, Katja; Weinholdt, Claus; Smith, Lisa M; Lummer, Martina; Speth, Corinna; Grosse, Ivo; Weigel, Detlef; Staiger, Dorothee

    2014-09-01

    The hnRNP-like glycine-rich RNA-binding protein AtGRP7 regulates pre-mRNA splicing in Arabidopsis. Here we used small RNA-seq to show that AtGRP7 also affects the miRNA inventory. AtGRP7 overexpression caused a significant reduction in the level of 30 miRNAs and an increase for 14 miRNAs with a minimum log2 fold change of ± 0.5. Overaccumulation of several pri-miRNAs including pri-miR398b, pri-miR398c, pri-miR172b, pri-miR159a and pri-miR390 at the expense of the mature miRNAs suggested that AtGRP7 affects pri-miRNA processing. Indeed, RNA immunoprecipitation revealed that AtGRP7 interacts with these pri-miRNAs in vivo. Mutation of an arginine in the RNA recognition motif abrogated in vivo binding and the effect on miRNA and pri-miRNA levels, indicating that AtGRP7 inhibits processing of these pri-miRNAs by direct binding. In contrast, pri-miRNAs of selected miRNAs that were elevated or not changed in response to high AtGRP7 levels were not bound in vivo. Reduced accumulation of miR390, an initiator of trans-acting small interfering RNA (ta-siRNA) formation, also led to lower TAS3 ta-siRNA levels and increased mRNA expression of the target AUXIN RESPONSE FACTOR4. Furthermore, AtGRP7 affected splicing of pri-miR172b and pri-miR162a. Thus, AtGRP7 is an hnRNP-like protein with a role in processing of pri-miRNAs in addition to its role in pre-mRNA splicing.

  13. Microprocessor dynamics shows co- and post-transcriptional processing of pri-miRNAs.

    Louloupi, Annita; Ntini, Evgenia; Liz, Julia; Ørom, Ulf Andersson

    2017-03-01

    miRNAs are small regulatory RNAs involved in the regulation of translation of target transcripts. miRNA biogenesis is a multi-step process starting with the cleavage of the primary miRNA transcript in the nucleus by the Microprocessor complex. Endogenous processing of pri-miRNAs is challenging to study and the in vivo kinetics of this process is not known. Here, we present a method for determining the processing kinetics of pri-miRNAs within intact cells over time using a pulse-chase approach to label transcribed RNA during 15 minutes and follow the processing within a 1-hour window after labeling with bromouridine. We show, that pri-miRNAs exhibit different processing kinetics ranging from fast over intermediate to slow processing and provide evidence that pri-miRNA processing can occur both co-transcriptionally and post-transcriptionally.

  14. Pri peptides are mediators of ecdysone for the temporal control of development.

    Chanut-Delalande, Hélène; Hashimoto, Yoshiko; Pelissier-Monier, Anne; Spokony, Rebecca; Dib, Azza; Kondo, Takefumi; Bohère, Jérôme; Niimi, Kaori; Latapie, Yvan; Inagaki, Sachi; Dubois, Laurence; Valenti, Philippe; Polesello, Cédric; Kobayashi, Satoru; Moussian, Bernard; White, Kevin P; Plaza, Serge; Kageyama, Yuji; Payre, François

    2014-11-01

    Animal development fundamentally relies on the precise control, in space and time, of genome expression. Whereas we have a wealth of information about spatial patterning, the mechanisms underlying temporal control remain poorly understood. Here we show that Pri peptides, encoded by small open reading frames, are direct mediators of the steroid hormone ecdysone for the timing of developmental programs in Drosophila. We identify a previously uncharacterized enzyme of ecdysone biosynthesis, GstE14, and find that ecdysone triggers pri expression to define the onset of epidermal trichome development, through post-translational control of the Shavenbaby transcription factor. We show that manipulating pri expression is sufficient to either put on hold or induce premature differentiation of trichomes. Furthermore, we find that ecdysone-dependent regulation of pri is not restricted to epidermis and occurs over various tissues and times. Together, these findings provide a molecular framework to explain how systemic hormonal control coordinates specific programs of differentiation with developmental timing.

  15. Pri sORF peptides induce selective proteasome-mediated protein processing.

    Zanet, J; Benrabah, E; Li, T; Pélissier-Monier, A; Chanut-Delalande, H; Ronsin, B; Bellen, H J; Payre, F; Plaza, S

    2015-09-18

    A wide variety of RNAs encode small open-reading-frame (smORF/sORF) peptides, but their functions are largely unknown. Here, we show that Drosophila polished-rice (pri) sORF peptides trigger proteasome-mediated protein processing, converting the Shavenbaby (Svb) transcription repressor into a shorter activator. A genome-wide RNA interference screen identifies an E2-E3 ubiquitin-conjugating complex, UbcD6-Ubr3, which targets Svb to the proteasome in a pri-dependent manner. Upon interaction with Ubr3, Pri peptides promote the binding of Ubr3 to Svb. Ubr3 can then ubiquitinate the Svb N terminus, which is degraded by the proteasome. The C-terminal domains protect Svb from complete degradation and ensure appropriate processing. Our data show that Pri peptides control selectivity of Ubr3 binding, which suggests that the family of sORF peptides may contain an extended repertoire of protein regulators.

  16. Effect of nitrogen stress on relationship of PRI and LUE during winter wheat growth period

    Guo, Jianmao; Gao, Yanghua; Wang, Qian; Fei, Dunyue; Liu, Junwei

    2014-11-01

    Light use efficiency (LUE ) is an important parameter for GPP and and NPP estimation model, cause by the existing model method to estimate the actual LUE is always simple and rough, which may lead to serious bias by GPP and NPP. The photochemical reflectance index ( PRI ) has great potential for direct estimation the actual LUE. In this paper, wheat in different nitrogen treatments was designed in field trial during Wheat growing period, for obtain photosynthesis and reflective hyperspectral data, and then LUE and PRI was calculated in critical period of wheat growth. The results show that, at different growth stages under three different nitrogen conditions, LUE and PRI value were significantly increased with increasing nitrogen absorption; Last longer, more capable of absorbing nitrogen amount, the correlation between LUE and PRI was better - for example, the correlation coefficient is obviously larger in heading stage than elongation stage for same nitrogen treatment.

  17. Remote sensing of ecosystem light use efficiency with MODIS-based PRI

    Goerner, A.; Reichstein, M.; Tomelleri, E.; Hanan, N.; Rambal, S.; Papale, D.; Dragoni, D.; Schmullius, C.

    2011-01-01

    Several studies sustained the possibility that a photochemical reflectance index (PRI) directly obtained from satellite data can be used as a proxy for ecosystem light use efficiency (LUE) in diagnostic models of gross primary productivity. This modelling approach would avoid the complications that are involved in using meteorological data as constraints for a fixed maximum LUE. However, no unifying model predicting LUE across climate zones and time based on MODIS PRI has been published to date. In this study, we evaluate the effectiveness with which MODIS-based PRI can be used to estimate ecosystem light use efficiency at study sites of different plant functional types and vegetation densities. Our objective is to examine if known limitations such as dependence on viewing and illumination geometry can be overcome and a single PRI-based model of LUE (i.e. based on the same reference band) can be applied under a wide range of conditions. Furthermore, we were interested in the effect of using different faPAR (fraction of absorbed photosynthetically active radiation) products on the in-situ LUE used as ground truth and thus on the whole evaluation exercise. We found that estimating LUE at site-level based on PRI reduces uncertainty compared to the approaches relying on a maximum LUE reduced by minimum temperature and vapour pressure deficit. Despite the advantages of using PRI to estimate LUE at site-level, we could not establish an universally applicable light use efficiency model based on MODIS PRI. Models that were optimised for a pool of data from several sites did not perform well.

  18. Structural and functional characterization of the CAP domain of pathogen-related yeast 1 (Pry1) protein

    Darwiche, Rabih; Kelleher, Alan; Hudspeth, Elissa M.; Schneiter, Roger; Asojo, Oluwatoyin A.

    2016-06-01

    The production, crystal structure, and functional characterization of the C-terminal cysteine-rich secretory protein/antigen 5/pathogenesis related-1 (CAP) domain of pathogen-related yeast protein-1 (Pry1) from Saccharomyces cerevisiae is presented. The CAP domain of Pry1 (Pry1CAP) is functional in vivo as its expression restores cholesterol export to yeast mutants lacking endogenous Pry1 and Pry2. Recombinant Pry1CAP forms dimers in solution, is sufficient for in vitro cholesterol binding, and has comparable binding properties as full-length Pry1. Two crystal structures of Pry1CAP are reported, one with Mg2+ coordinated to the conserved CAP tetrad (His208, Glu215, Glu233 and His250) in spacegroup I41 and the other without divalent cations in spacegroup P6122. The latter structure contains four 1,4-dioxane molecules from the crystallization solution, one of which sits in the cholesterol binding site. Both structures reveal that the divalent cation and cholesterol binding sites are connected upon dimerization, providing a structural basis for the observed Mg2+-dependent sterol binding by Pry1.

  19. 新体制雷达信号 PRI 样本子图周期搜索提取方法%A New System Radar Signal Extraction Method by Searching PRI Pulse Sequence Subpattern Cycle

    孟祥豪; 罗景青; 马贤同

    2015-01-01

    alming at the problem of radar signal extraction of interleaved pulse sequences intercepted by reconnalssance receiver,according to the description technique of pulse recurrence interval(PRI),a pulse extraction algorithm is proposed based on the searching of PRI pulse sequence subpattern(PSS)cycle.In this algorithm,the idea of searching adjacent pul-ses intervals in traditional PRI searching algorithm is replaced by that of searching the PRI-PSS cycle.A two-dimensional extraction function consisting of time of arrival and paracycle of PRI PSS is constructed to store the number of matching pul-ses which conform to a certaln assumed PRI-PSS cycle during the searching process.Then the PRI-PSS cycle is determined according to the maximum value of the function,thus the equivalent pulses can be extracted,realizing the signal extraction of complex type of PRI radar signals.The validity of this method has been verified by simulation experiments.%针对侦察接收机截获的交错脉冲序列中雷达信号的提取问题,在脉冲重复周期(PRI)样本子图描述技术的基础上,提出一种基于 PRI 样本子图周期搜索的脉冲提取算法。算法改传统 PRI 搜索法中的相邻脉冲间隔搜索思想为 PRI 样本子图周期搜索思想,通过构造由脉冲到达时间和准 PRI 样本子图周期构成的二维提取函数,将搜索过程中符合某一假定 PRI 样本子图周期的匹配脉冲数存储于二维提取函数中,然后根据二维提取函数的最大值确定 PRI 样本子图周期,提取对应的脉冲,实现复杂 PRI 类型的雷达信号提取。仿真结果验证了该方法的有效性。

  20. Diurnal and Directional Responses of Chlorophyll Fluorescence and the PRI in a Cornfield

    Middleton, Elizabeth; Cheng, Y. B.; Corp, L.; Campbell, P.; Kustas, W.

    2010-01-01

    Determining the health and vigor of vegetation using high spectral resolution remote sensing is an important goal which has application to monitoring agriculture and ecosystem productivity and carbon exchange. Two spectral indices used to assess whether vegetation is performing near-optimally or exhibiting symptoms of environmental stress (e.g., drought or nutrient deficiency, non-optimal temperatures, etc.) are the Photochemical Reflectance Index (PRI) and solar-induced red and far-red Chlorophyll Fluorescence (Fs). Both the PRI and Fs capture the dynamics of photoprotection mechanisms within green foliage: the PRI is based on the association of the reflected radiation in the green spectrum with the xanthophyll cycle, whereas Fs measures the emitted radiation in the red and far-red spectrum. Fs was determined from retrievals in the atmospheric oxygen absorption features centered at 688 and 760 nm using a modified Fraunhofer Line Depth (FLD) method. We previously demonstrated diurnal and seasonal PRI differences for sunlit vs. shaded foliage in a conifer forest canopy, as expressed in the hotspot and darkspot of the Bidirectional Reflectance Function (BRF). In a USDA-ARS experimental field site located in Beltsville, MD, USA, measurements were acquired over a corn crop from a nadir view in 2008 with an ASD FieldSpec Pro (Analytical Spectral Devices, Inc., Boulder, CO, USA) to study the behavior of the PRI for sunlit and shaded foliage as captured in reflectance variations associated with the BRF, in a I m tall canopy in the vegetative growth stage. Those observations were compared to simulations obtained from two radiative transfer models. Measurements were then acquired to examine whether the PRI and Fs were influenced by view zenith and azimuth geometries at different times of day. Those measurements were made in 2010 with the Ocean Optics USB4000 Miniature Fiber Optic Spectrometer (Ocean Optics Inc., Dunedin, Florida, USA) at several times during the day on

  1. Gene structures and processing of Arabidopsis thaliana HYL1-dependent pri-miRNAs.

    Szarzynska, Bogna; Sobkowiak, Lukasz; Pant, Bikram Datt; Balazadeh, Salma; Scheible, Wolf-Rüdiger; Mueller-Roeber, Bernd; Jarmolowski, Artur; Szweykowska-Kulinska, Zofia

    2009-05-01

    Arabidopsis thaliana HYL1 is a nuclear double-stranded RNA-binding protein involved in the maturation of pri-miRNAs. A quantitative real-time PCR platform for parallel quantification of 176 pri-miRNAs was used to reveal strong accumulation of 57 miRNA precursors in the hyl1 mutant that completely lacks HYL1 protein. This approach enabled us for the first time to pinpoint particular members of MIRNA family genes that require HYL1 activity for efficient maturation of their precursors. Moreover, the accumulation of miRNA precursors in the hyl1 mutant gave us the opportunity to carry out 3' and 5' RACE experiments which revealed that some of these precursors are of unexpected length. The alignment of HYL1-dependent miRNA precursors to A. thaliana genomic sequences indicated the presence of introns in 12 out of 20 genes studied. Some of the characterized intron-containing pri-miRNAs undergo alternative splicing such as exon skipping or usage of alternative 5' splice sites suggesting that this process plays a role in the regulation of miRNA biogenesis. In the hyl1 mutant intron-containing pri-miRNAs accumulate alongside spliced pri-miRNAs suggesting the recruitment of HYL1 into the miRNA precursor maturation pathway before their splicing occurs.

  2. PRI-Modeler: extracting RNA structural elements from PDB files of protein-RNA complexes.

    Han, Kyungsook; Nepal, Chirag

    2007-05-01

    A complete understanding of protein and RNA structures and their interactions is important for determining the binding sites in protein-RNA complexes. Computational approaches exist for identifying secondary structural elements in proteins from atomic coordinates. However, similar methods have not been developed for RNA, due in part to the very limited structural data so far available. We have developed a set of algorithms for extracting and visualizing secondary and tertiary structures of RNA and for analyzing protein-RNA complexes. These algorithms have been implemented in a web-based program called PRI-Modeler (protein-RNA interaction modeler). Given one or more protein data bank files of protein-RNA complexes, PRI-Modeler analyzes the conformation of the RNA, calculates the hydrogen bond (H bond) and van der Waals interactions between amino acids and nucleotides, extracts secondary and tertiary RNA structure elements, and identifies the patterns of interactions between the proteins and RNAs. This paper presents PRI-Modeler and its application to the hydrogen bond and van der Waals interactions in the most representative set of protein-RNA complexes. The analysis reveals several interesting interaction patterns at various levels. The information provided by PRI-Modeler should prove useful for determining the binding sites in protein-RNA complexes. PRI-Modeler is accessible at http://wilab.inha.ac.kr/primodeler/, and supplementary materials are available in the analysis results section at http://wilab.inha.ac.kr/primodeler/.

  3. Subnuclear compartmentalization of transiently expressed polyadenylated pri-microRNAs: processing at transcription sites or accumulation in SC35 foci.

    Pawlicki, Jan M; Steitz, Joan A

    2009-02-01

    MicroRNAs (miRNAs) are small, noncoding RNAs that post-transcriptionally regulate expression of their target messenger RNAs. We recently demonstrated that primary miRNA transcripts (pri-miRNAs) retained at transcription sites are processed with enhanced efficiency, suggesting that pri-miRNA processing is coupled to transcription in mammalian cells. We also observed that transiently expressed pri-miRNAs accumulate in nuclear foci with splicing factor SC35 and Microprocessor components, Drosha and DGCR8. Here, we show that pri-miRNAs containing a self-cleaving hepatitis delta ribozyme accumulate in the nucleoplasm after release from their transcription sites, but are not efficiently processed. Pri-miRNAs with ribozyme-generated 3' ends do not localize to SC35-containing foci, whereas cleaved and polyadenylated pri-miRNA transcripts with or without the pre-miRNA hairpin do. Pri-miRNA/SC35 foci contain a number of proteins normally associated with SC35 domains, including ASF/SF2, PABII, and the prolyl isomerase, Pin1. In contrast, RNA polymerase II and PM/Scl-100 do not strongly colocalize with pri-miRNAs in SC35-containing foci. These data argue that pri-miRNA/SC35-containing foci are not major sites of pri-miRNA processing and that pri-miRNA processing is coupled to transcription. We discuss the implications of our findings relative to recent insights into miRNA biogenesis, mRNA metabolism, and the nuclear organization of gene expression.

  4. Fluorescence, PRI and canopy temperature for water stress detection in cereal crops

    Panigada, C.; Rossini, M.; Meroni, M.; Cilia, C.; Busetto, L.; Amaducci, S.; Boschetti, M.; Cogliati, S.; Picchi, V.; Pinto, F.; Marchesi, A.; Colombo, R.

    2014-08-01

    Narrow-band multispectral remote sensing techniques and thermal imagery were investigated for water stress detection in cereal crops. Visible and near infrared AISA Eagle (Specim, Finland) and thermal AHS-160 (Sensytech Inc., USA) imageries were acquired with an airborne survey on a farm-level experimental site where maize (Zea mays L.) and sorghum (Sorghum bicolor L.) were grown with three different irrigation treatments. Vegetation biophysical and eco-physiological measurements were collected concurrently with the airborne campaign. Leaf fluorescence yield (ΔF/Fm‧) resulted to be a good indirect measure of water stress. Therefore, ΔF/Fm‧ measurements were compared against remotely sensed indicators: (i) the Photochemical Reflectance Index (PRI), (ii) the sun-induced chlorophyll fluorescence at 760 nm (F760), retrieved by the Fraunhofer line depth method and (iii) the canopy temperature (TC) calculated decoupling soil and vegetation contributions. TC was related to ΔF/Fm‧ with the highest determination coefficient (R2 = 0.65), followed by PRI586 (reference band at 586 nm) (R2 = 0.51). The relationship with F760 was significant but weaker (R2 = 0.36). The coefficient of determination increased up to 0.54 when pigment concentration was considered by multiplying ΔF/Fm‧ and chlorophyll content, confirming the close relationship between passive fluorescence signal, pigment content and light photosystem efficiency. PRI586, F760 and TC maps were produced in maize and sorghum plots. The differences in the average values of PRI586, F760 and TC extracted from the plots with different water treatments showed that water treatments were well discriminated in maize plots by the three remotely sensed indicators. This was confirmed by the visual observation of the PRI586, F760 and TC maps, while in sorghum plots, F760 and TC appeared more sensitive to water stress compared to PRI586.

  5. 7 CFR 14.6 - Criteria for determining the pri- mary purpose of payments with respect to potential exclusion...

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Criteria for determining the pri- mary purpose of payments with respect to potential exclusion from gross income. 14.6 Section 14.6 Agriculture Office of the... Criteria for determining the pri- mary purpose of payments with respect to potential exclusion from...

  6. Bidirectional processing of pri-miRNAs with branched terminal loops by Arabidopsis Dicer-like1.

    Zhu, Hongliang; Zhou, Yuyi; Castillo-González, Claudia; Lu, Amber; Ge, Chunxiao; Zhao, Ying-Tao; Duan, Liusheng; Li, Zhaohu; Axtell, Michael J; Wang, Xiu-Jie; Zhang, Xiuren

    2013-09-01

    MicroRNAs (miRNAs) originate from primary transcripts (pri-miRNAs) with characteristic stem-loop structures, and their accurate processing is required for the production of functional miRNAs. Here, using the pri-miR-166 family in Arabidopsis thaliana as a paradigm, we report the crucial role of pri-miRNA terminal loops in miRNA biogenesis. We found that multibranched terminal loops in pri-miR-166s substantially suppress miR-166 expression in vivo. Unlike canonical processing of pri-miRNAs, terminal loop-branched pri-miRNAs can be processed by Dicer-like 1 (DCL1) complexes bidirectionally from base to loop and from loop to base, resulting in productive and abortive processing of miRNAs, respectively. In both cases, DCL1 complexes canonically cut pri-miRNAs at a distance of 16-17 bp from a reference single-stranded loop region. DCL1 also adjusts processing sites toward an internal loop through its helicase domain. These results provide new insight into the poorly understood processing mechanism of pri-miRNAs with complex secondary structures.

  7. PriFi - Using a Multiple Alignment of Related Sequences to Find Primers for  Amplification of Homologs

    Fredslund, Jakob; Schauser, Leif; Madsen, Lene Heegaard;

    2005-01-01

    Using a comparative approach, the web program PriFi (http://cgi-www.daimi.au.dk/cgi-chili/PriFi/main) designs pairs of primers useful for PCR amplification of genomic DNA in species where prior sequence information is not available. The program works with an alignment of DNA sequences from...

  8. Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins.

    Coelho, Miguel B; Ascher, David B; Gooding, Clare; Lang, Emma; Maude, Hannah; Turner, David; Llorian, Miriam; Pires, Douglas E V; Attig, Jan; Smith, Christopher W J

    2016-08-15

    Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm. PTBP1 has four RNA binding domains of the RNA recognition motif (RRM) family, each of which can bind to pyrimidine motifs. In addition, RRM2 can interact via its dorsal surface with proteins containing short peptide ligands known as PTB RRM2 interacting (PRI) motifs, originally found in the protein Raver1. Here we review our recent progress in understanding the interactions of PTB with RNA and with various proteins containing PRI ligands.

  9. Drevesno preiskovanje Monte Carlo s Thompsonovim vzorčenjem pri igri Prebivalci otoka Catan

    2016-01-01

    Drevesno preiskovanje Monte Carlo (MCTS) je ena izmed najbolj uporabljenih metod pri implementaciji močnega računalniškega igralca iger v umetni inteligenci, brez uporabe predhodnega znanja o domeni. Najmočnejši in najbolj popularni algoritmi, ki se pogosto uporabljajo za rešitev t.i. dileme raziskovanja (engl. exploration) proti izkoriščanju znanja (engl. exploitation) pri problemu več-rokih banditov, so raziskani in predstavljeni s pomočjo pregleda literature. Na podlagi empiričnih študij T...

  10. Tertiary structure mapping of the pri-miRNA miR-17~92.

    Chaulk, Steven G; Fahlman, Richard P

    2014-01-01

    The understanding of RNA in regulating gene expression has exploded over the past 15 years. MicroRNAs (miRNAs) have vastly expanded the role of RNA in gene regulation beyond spliceosomal, ribosomal, and messenger RNAs. Approximately one half of miRNAs are polycistronic, where two or more miRNAs are encoded on a single pri-miRNA transcript, termed a miRNA cluster. The six miRNAs of the miR-17~92 cluster are contained within a ~800 nucleotide region within intron 3 of the cl13orf25 ~7 kb pri-miRNA transcript. We recently reported on the tertiary structured domain of miR-17~92 and its role in modulating miRNA biogenesis. The key finding was that the cluster structure explained the differential processing of the miRNA hairpins by Drosha. This work demonstrated the need to consider pri-miRNA tertiary structure in miRNA biogenesis. Since biochemical structure probing is typically performed on relatively short RNAs (≤200 nucleotides), we had to adapt these methodologies for application on large RNAs (~800 nucleotide miR-17~92 pri-miRNA). We present here our adaptation of a protection footprinting method using ribonucleases to probe the structure of the ~800 nucleotide miR-17~92 pri-miRNA. We outline the technical difficulties involved in probing large RNAs and data visualization using denaturing polyacrylamide gel electrophoresis and how we adapted the existing approaches to probe large RNAs. The methodology outlined here is generally applicable to large RNAs including long noncoding RNAs (lncRNA).

  11. Dimeric structure of the N-terminal domain of PriB protein from Thermoanaerobacter tengcongensis solved ab initio.

    Liebschner, Dorothee; Brzezinski, Krzysztof; Dauter, Miroslawa; Dauter, Zbigniew; Nowak, Marta; Kur, Józef; Olszewski, Marcin

    2012-12-01

    PriB is one of the components of the bacterial primosome, which catalyzes the reactivation of stalled replication forks at sites of DNA damage. The N-terminal domain of the PriB protein from the thermophilic bacterium Thermoanaerobacter tengcongensis (TtePriB) was expressed and its crystal structure was solved at the atomic resolution of 1.09 Å by direct methods. The protein chain, which encompasses the first 104 residues of the full 220-residue protein, adopts the characteristic oligonucleotide/oligosaccharide-binding (OB) structure consisting of a five-stranded β-barrel filled with hydrophobic residues and equipped with four loops extending from the barrel. In the crystal two protomers dimerize, forming a six-stranded antiparallel β-sheet. The structure of the N-terminal OB domain of T. tengcongensis shows significant differences compared with mesophile PriBs. While in all other known structures of PriB a dimer is formed by two identical OB domains in separate chains, TtePriB contains two consecutive OB domains in one chain. However, sequence comparison of both the N-terminal and the C-terminal domains of TtePriB suggests that they have analogous structures and that the natural protein possesses a structure similar to a dimer of two N-terminal domains.

  12. Association of a peptoid ligand with the apical loop of pri-miR-21 inhibits cleavage by Drosha.

    Diaz, Jason P; Chirayil, Rachel; Chirayil, Sara; Tom, Martin; Head, Katie J; Luebke, Kevin J

    2014-04-01

    We have found a small molecule that specifically inhibits cleavage of a precursor to the oncogenic miRNA, miR-21, by the microprocessor complex of Drosha and DGCR8. We identified novel ligands for the apical loop of this precursor from a screen of 14,024 N-substituted oligoglycines (peptoids) in a microarray format. Eight distinct compounds with specific affinity were obtained, three having affinities for the targeted loop in the low micromolar range and greater than 15-fold discrimination against a closely related hairpin. One of these compounds completely inhibits microprocessor cleavage of a miR-21 primary transcript at concentrations at which cleavage of another miRNA primary transcript, pri-miR-16, is little affected. The apical loop of pri-miR-21, placed in the context of pri-miR-16, is sufficient for inhibition of microprocessor cleavage by the peptoid. This compound also inhibits cleavage of pri-miR-21 containing the pri-miR-16 apical loop, suggesting an additional site of association within pri-miR-21. The reported peptoid is the first example of a small molecule that inhibits microprocessor cleavage by binding to the apical loop of a pri-miRNA.

  13. Dimeric structure of the N-terminal domain of PriB protein from Thermoanaerobacter tengcongensis solved ab initio

    Liebschner, Dorothee [National Cancer Institute, Argonne National Laboratory, Argonne, IL 60439 (United States); Brzezinski, Krzysztof [National Cancer Institute, Argonne National Laboratory, Argonne, IL 60439 (United States); University of Bialystok, 15-399 Bialystok (Poland); Dauter, Miroslawa [Argonne National Laboratory, Argonne, IL 60439 (United States); Dauter, Zbigniew, E-mail: dauter@anl.gov [National Cancer Institute, Argonne National Laboratory, Argonne, IL 60439 (United States); Nowak, Marta; Kur, Józef; Olszewski, Marcin, E-mail: dauter@anl.gov [Gdansk University of Technology, 80-952 Gdansk (Poland); National Cancer Institute, Argonne National Laboratory, Argonne, IL 60439 (United States)

    2012-12-01

    The N-terminal domain of the PriB protein from the thermophilic bacterium T. tengcongensis (TtePriB) was expressed and its crystal structure has been solved at the atomic resolution of 1.09 Å by direct methods. PriB is one of the components of the bacterial primosome, which catalyzes the reactivation of stalled replication forks at sites of DNA damage. The N-terminal domain of the PriB protein from the thermophilic bacterium Thermoanaerobacter tengcongensis (TtePriB) was expressed and its crystal structure was solved at the atomic resolution of 1.09 Å by direct methods. The protein chain, which encompasses the first 104 residues of the full 220-residue protein, adopts the characteristic oligonucleotide/oligosaccharide-binding (OB) structure consisting of a five-stranded β-barrel filled with hydrophobic residues and equipped with four loops extending from the barrel. In the crystal two protomers dimerize, forming a six-stranded antiparallel β-sheet. The structure of the N-terminal OB domain of T. tengcongensis shows significant differences compared with mesophile PriBs. While in all other known structures of PriB a dimer is formed by two identical OB domains in separate chains, TtePriB contains two consecutive OB domains in one chain. However, sequence comparison of both the N-terminal and the C-terminal domains of TtePriB suggests that they have analogous structures and that the natural protein possesses a structure similar to a dimer of two N-terminal domains.

  14. Regulation of pri-miRNA processing by a long noncoding RNA transcribed from an ultraconserved region.

    Liz, Julia; Portela, Anna; Soler, Marta; Gómez, Antonio; Ling, Hui; Michlewski, Gracjan; Calin, George A; Guil, Sònia; Esteller, Manel

    2014-07-03

    Noncoding RNAs (ncRNAs) control cellular programs by affecting protein-coding genes, but evidence increasingly points to their involvement in a network of ncRNA-ncRNA interactions. Here, we show that a long ncRNA, Uc.283+A, controls pri-miRNA processing. Regulation requires complementarity between the lower stem region of the pri-miR-195 transcript and an ultraconserved sequence in Uc.283+A, which prevents pri-miRNA cleavage by Drosha. Mutation of the site in either RNA molecule uncouples regulation in vivo and in vitro. We propose a model in which lower-stem strand invasion by Uc.283+A impairs microprocessor recognition and efficient pri-miRNA cropping. In addition to identifying a case of RNA-directed regulation of miRNA biogenesis, our study reveals regulatory networks involving different ncRNA classes of importance in cancer.

  15. Construction of Pri-miR-20a Lentiviral Expression Vector%携带pri-mir-20a的慢病毒表达载体的构建

    马清华; 徐艳敏; 武佳; 李伟; 钱程; 刘立

    2010-01-01

    采用PCR扩增获得的pri-mir-20a,过渡质粒pcDNA3.0-H1经BamH Ⅰ与Hin dⅢ双酶切后将两者连接产生pcDNA3.0-H1-pri-mir-20a重组质粒,再将PCR获得的H1-pri-mir-20a克隆到慢病毒载体pdc-SEW上获得重组慢病毒载体pdcH1-pri-mir-20a-SEW.将pCMV 8.91、pMD2.VSV.G、pdcH1-pri-mir-20a-SEW三质粒共转染293FT细胞,结果显示48 h后绿色荧光蛋白的表达达到80%,表明已成功构建出携带pri-mir-20a的慢病毒表达载体.该载体的成功构建为深入开展对miR-20a的生物学功能和靶标验证提供了有效的工具.

  16. Remote detection of water stress conditions via a diurnal photochemical reflectance index (PRI) improves yield prediction in rainfed wheat

    Magney, T. S.; Vierling, L. A.; Eitel, J.

    2014-12-01

    Employing remotely sensed techniques to quantify the existence and magnitude of midday photosynthetic downregulation using the photochemical reflectance index (PRI) may reveal new information about plant responses to abiotic stressors in space and time. However, the interpretation and application of the PRI can be confounded because of its sensitivity to several variables changing at the diurnal (e.g., irradiation, shadow fraction) and seasonal (e.g., leaf area, chlorophyll and carotene pigment concentrations, irradiation) time scales. We explored different techniques to correct the PRI for variations in canopy structure and relative chlorophyll content (ChlR) using highly temporally resolved (frequency = five minutes) in-situ radiometric measurements of PRI and the Normalized Difference Vegetation Index (NDVI) over eight soft white spring wheat (Triticum aestivum L.)field plots under varying nitrogen and soil water conditions over two seasons. Our results suggest that the influence of seasonal variation in canopy ChlR and LAI on the diurnally measured PRI (PRIdiurnal) can be minimized using simple correction techniques, therefore improving the strength of PRI as a tool to quantify abiotic stressors such as daily changes in soil volumetric water content (SVWC), and vapor pressure deficit (VPD). PRIdiurnal responded strongly to available nitrogen, and linearly tracked seasonal changes in SVWC, VPD, and stomatal conductance (gc). Utilizing the PRI as an indicator of stress, yield predictions significantly over greenness indices such as the NDVI. This study provides insight towards the future interpretation and scaling of PRI to quantify rapid changes in photosynthesis, and as an indicator of plant stress.

  17. A central role for the primary microRNA stem in guiding the position and efficiency of Drosha processing of a viral pri-miRNA.

    Burke, James M; Kelenis, Demetra P; Kincaid, Rodney P; Sullivan, Christopher S

    2014-07-01

    Processing of primary microRNA (pri-miRNA) stem-loops by the Drosha-DGCR8 complex is the initial step in miRNA maturation and crucial for miRNA function. Nonetheless, the underlying mechanism that determines the Drosha cleavage site of pri-miRNAs has remained unclear. Two prevalent but seemingly conflicting models propose that Drosha-DGCR8 anchors to and directs cleavage a fixed distance from either the basal single-stranded (ssRNA) or the terminal loop. However, recent studies suggest that the basal ssRNA and/or the terminal loop may influence the Drosha cleavage site dependent upon the sequence/structure of individual pri-miRNAs. Here, using a panel of closely related pri-miRNA variants, we further examine the role of pri-miRNA structures on Drosha cleavage site selection in cells. Our data reveal that both the basal ssRNA and terminal loop influence the Drosha cleavage site within three pri-miRNAs, the Simian Virus 40 (SV40) pri-miRNA, pri-miR-30a, and pri-miR-16. In addition to the flanking ssRNA regions, we show that an internal loop within the SV40 pri-miRNA stem strongly influences Drosha cleavage position and efficiency. We further demonstrate that the positions of the internal loop, basal ssRNA, and the terminal loop of the SV40 pri-miRNA cooperatively coordinate Drosha cleavage position and efficiency. Based on these observations, we propose that the pri-miRNA stem, defined by internal and flanking structural elements, guides the binding position of Drosha-DGCR8, which consequently determines the cleavage site. This study provides mechanistic insight into pri-miRNA processing in cells that has numerous biological implications and will assist in refining Drosha-dependent shRNA design.

  18. VARNOSTNA TVEGANJA PRI RAZVOJU INFORMACIJSKIH REŠITEV S POMOČJO SISTEMOV ZA UPRAVLJANJE VSEBIN

    Leskovar, Uroš

    2015-01-01

    V diplomskem delu je obravnavana problematika varnostnih tveganj pri razvoju in uporabi informacijskih rešitev kadar uporabljamo sisteme za upravljanje vsebin. Varnost v informacijskih sistemih je pogosto ogrožena, kljub vedno novejšim tehnologijam. Diplomsko delo zajema splošen opis treh najpogostejših sistemov za upravljanje vsebin, primerjavo preteklih testiranj sistemov, varnostno testiranje s pomočjo navodil drugih organizacij in pregled najpogostejših nevarnosti. Ugotovljeno je bilo, da...

  19. Pri-miR-124 rs531564 polymorphism and colorectal cancer risk.

    Gao, Xue-Ren; Wang, Hui-Ping; Zhang, Shu-Long; Wang, Ming-Xi; Zhu, Zhan-Sheng

    2015-10-01

    MiR-124 functions as a tumor suppressor and plays an important role in tumorigenesis. A common polymorphism (rs531564, C>G) in the pri-miR-124 has been recently studied in connection with cancer risk. The aim of the present study was to investigate the association between pri-miR-124 rs531564 polymorphism and the risk and clinicopathological characteristics of colorectal cancer (CRC). Two case-control studies involving 900 CRC patients and 1110 cancer-free controls showed that pri-miR-124 rs531564 polymorphism was significantly associated with the decreased risk of CRC in Xuzhou population [GG vs. CC: OR = 0.25, 95%CI = 0.09-0.67, P = 0.003; (CG+GG) vs. CC: OR = 0.73, 95%CI = 0.56-0.94, P = 0.01; GG vs. (CC+CG): OR = 0.27, 95%CI = 0.10-0.70, P = 0.004; G vs. C: OR = 0.70, 95%CI = 0.56-0.89, P = 0.003], Bengbu population [GG vs. CC: OR = 0.20, 95%CI = 0.04-0.90, P = 0.02; GG vs. (CC+CG): OR = 0.21, 95%CI = 0.05-0.95, P = 0.03; G vs. C: OR = 0.72, 95%CI = 0.54-0.98, P = 0.03] and pooled population [GG vs. CC: OR = 0.26, 95%CI = 0.11-0.59, Ppri-miR-124 rs531564 polymorphism was significantly associated with the decreased risk of poor differentiation and lymph node metastasis of CRC. Our results suggest that pri-miR-124 rs531564 polymorphism may be a genetic modifier for developing CRC. However, further studies are needed to validate our findings.

  20. Stimulation of pri-miR-18a Processing by hnRNP A1.

    Michlewski, Gracjan; Guil, Sonia; Cáceres, Javier F

    2011-01-01

    Recent evidence suggests that the canonical miRNA processing pathway can be regulated by a number of positive and negative trans-acting factors. This chapter provides an overview of hnRNP Al-mediated regulation of miR-18a biogenesis. Our laboratory has recently established that the multifunctional RNA-binding protein hnRNP Al is required for the processing of miR-18a at the nuclear step of Drosha-mediated processing. By combining structural and functional analysis of RNA, we showed that hnRNP Al regulates the processing of pri-miR-18a by binding to its terminal loop and reshaping its stem-loop structure, thus allowing for a more effective Drosha cleavage. Furthermore, we linked the event of hnRNP A1-binding to the pri-miR-18a with an unusual phylogenetic sequence conservation of its terminal loop. Bioinformatic and mutational analysis revealed that a number of pri-miRNAs have highly conserved terminal loops, which are predicted to act as landing pads for trans-acting factors influencing miRNA processing. These results underscore a previously uncharacterized role for general RNA-binding proteins as factors that facilitate the processing of specific miRNAs, revealing an additional level of complexity for the regulation of miRNA production and function.

  1. Remote sensing of ecosystem light use efficiency with MODIS-based PRI - the DOs and DON'Ts

    Goerner, A.; Reichstein, M.; Tomelleri, E.; Hanan, N.; Rambal, S.; Papale, D.; Dragoni, D.; Schmullius, C.

    2010-09-01

    Several studies sustained the possibility that a photochemical reflectance index (PRI) directly obtained from satellite data can be used as a proxy for ecosystem light use efficiency (LUE) in diagnostic models of gross primary productivity. This modelling approach would avoid the complications that are involved in using meteorological data as constraints for a fixed maximum LUE. However, no unifying model predicting LUE across climate zones and time based on MODIS PRI has been published to date. In this study, we evaluate the efficiency with which MODIS-based PRI can be used to estimate ecosystem light use efficiency at study sites of different plant functional types and vegetation densities. Our objective is to examine if known limitations such as dependance on viewing and illumination geometry can be overcome and a single PRI-based model of LUE (i.e. based on the same reference band) can be applied under a wide range of conditions. Furthermore, we were interested in the effect of using different faPAR (fraction of absorbed photosynthetically active radiation) products on the in-situ LUE used as ground truth and thus on the whole evaluation exercise. We found that estimating LUE at site-level based on PRI reduces uncertainty compared to the approaches relying on a maximum LUE reduced by minimum temperature and vapour pressure deficit. Despite the advantages of using PRI to estimate LUE at site-level, we could not establish an universally applicable light use efficiency model based on MODIS PRI. Models that were optimised for a pool of data from several sites did not perform well.

  2. mirTarPri: improved prioritization of microRNA targets through incorporation of functional genomics data.

    Peng Wang

    Full Text Available MicroRNAs (miRNAs are a class of small (19-25 nt non-coding RNAs. This important class of gene regulator downregulates gene expression through sequence-specific binding to the 3'untranslated regions (3'UTRs of target mRNAs. Several computational target prediction approaches have been developed for predicting miRNA targets. However, the predicted target lists often have high false positive rates. To construct a workable target list for subsequent experimental studies, we need novel approaches to properly rank the candidate targets from traditional methods. We performed a systematic analysis of experimentally validated miRNA targets using functional genomics data, and found significant functional associations between genes that were targeted by the same miRNA. Based on this finding, we developed a miRNA target prioritization method named mirTarPri to rank the predicted target lists from commonly used target prediction methods. Leave-one-out cross validation has proved to be successful in identifying known targets, achieving an AUC score up to 0. 84. Validation in high-throughput data proved that mirTarPri was an unbiased method. Applying mirTarPri to prioritize results of six commonly used target prediction methods allowed us to find more positive targets at the top of the prioritized candidate list. In comparison with other methods, mirTarPri had an outstanding performance in gold standard and CLIP data. mirTarPri was a valuable method to improve the efficacy of current miRNA target prediction methods. We have also developed a web-based server for implementing mirTarPri method, which is freely accessible at http://bioinfo.hrbmu.edu.cn/mirTarPri.

  3. Remote sensing of ecosystem light use efficiency with MODIS-based PRI – the DOs and DON'Ts

    A. Goerner

    2010-09-01

    Full Text Available Several studies sustained the possibility that a photochemical reflectance index (PRI directly obtained from satellite data can be used as a proxy for ecosystem light use efficiency (LUE in diagnostic models of gross primary productivity. This modelling approach would avoid the complications that are involved in using meteorological data as constraints for a fixed maximum LUE. However, no unifying model predicting LUE across climate zones and time based on MODIS PRI has been published to date. In this study, we evaluate the efficiency with which MODIS-based PRI can be used to estimate ecosystem light use efficiency at study sites of different plant functional types and vegetation densities. Our objective is to examine if known limitations such as dependance on viewing and illumination geometry can be overcome and a single PRI-based model of LUE (i.e. based on the same reference band can be applied under a wide range of conditions. Furthermore, we were interested in the effect of using different faPAR (fraction of absorbed photosynthetically active radiation products on the in-situ LUE used as ground truth and thus on the whole evaluation exercise. We found that estimating LUE at site-level based on PRI reduces uncertainty compared to the approaches relying on a maximum LUE reduced by minimum temperature and vapour pressure deficit. Despite the advantages of using PRI to estimate LUE at site-level, we could not establish an universally applicable light use efficiency model based on MODIS PRI. Models that were optimised for a pool of data from several sites did not perform well.

  4. Prion-like nanofibrils of small molecules (PriSM): A new frontier at the intersection of supramolecular chemistry and cell biology.

    Zhou, Jie; Du, Xuewen; Xu, Bing

    2015-01-01

    Formed by non-covalent interactions and not defined at genetic level, the assemblies of small molecules in biology are complicated and less explored. A common morphology of the supramolecular assemblies of small molecules is nanofibrils, which coincidentally resembles the nanofibrils formed by proteins such as prions. So these supramolecular assemblies are termed as prion-like nanofibrils of small molecules (PriSM). Emerging evidence from several unrelated fields over the past decade implies the significance of PriSM in biology and medicine. This perspective aims to highlight some recent advances of the research on PriSM. This paper starts with description of the intriguing similarities between PriSM and prions, discusses the paradoxical features of PriSM, introduces the methods for elucidating the biological functions of PriSM, illustrates several examples of beneficial aspects of PriSM, and finishes with the promises and current challenges in the research of PriSM. We anticipate that the research of PriSM will contribute to the fundamental understanding at the intersection of supramolecular chemistry and cell biology and ultimately lead to a new paradigm of molecular (or supramolecular) therapeutics for biomedicine.

  5. PRI-CAT: a web-tool for the analysis, storage and visualization of plant ChIP-seq experiments.

    Muiño, Jose M; Hoogstraat, Marlous; van Ham, Roeland C H J; van Dijk, Aalt D J

    2011-07-01

    Although several tools for the analysis of ChIP-seq data have been published recently, there is a growing demand, in particular in the plant research community, for computational resources with which such data can be processed, analyzed, stored, visualized and integrated within a single, user-friendly environment. To accommodate this demand, we have developed PRI-CAT (Plant Research International ChIP-seq analysis tool), a web-based workflow tool for the management and analysis of ChIP-seq experiments. PRI-CAT is currently focused on Arabidopsis, but will be extended with other plant species in the near future. Users can directly submit their sequencing data to PRI-CAT for automated analysis. A QuickLoad server compatible with genome browsers is implemented for the storage and visualization of DNA-binding maps. Submitted datasets and results can be made publicly available through PRI-CAT, a feature that will enable community-based integrative analysis and visualization of ChIP-seq experiments. Secondary analysis of data can be performed with the aid of GALAXY, an external framework for tool and data integration. PRI-CAT is freely available at http://www.ab.wur.nl/pricat. No login is required.

  6. [Effects of N, K fertilization on the relationship between photosynthetic light use efficiency and photochemical reflectance index (PRI)].

    Wu, Chao-Yang; Niu, Zheng; Tang, Quan; Huang, Wen-Jiang

    2009-02-01

    PRI (Photochemical reflectance index) has provided a fast and reliable method for estimating photosynthetic light use efficiency across species. Increasing efforts have been paid to explore the effects of such disturbances as water content and CO2 concentration on the relationship between PRI and LUE. In the present paper, five types of wheat with different nitrogen and kalium fertilization were selected to study the influence of varied fertilization levels on the relationship between PRI and LUE. The results proved that leaf chlorophyll contents as well as canopy PRI increased with the increase in nitrogen and kalium fertilization. For all the nitrogen and kalium fertilization of wheat, the regression coefficients R2 are 0.710 4 and 0.853 4 respectively. When considering different levels of fertilization, the regression coefficients R2 are 0.602 0, 0.640 4 and 0.801 4 for three types of nitrogen fertilization, and 0.379 1, 0.640 4 and 0.676 9 for kalium fertilization. Therefore, PRI not only can be a reliable indicator of LUE but also can reflect the fertilization situation of wheat with different precisions of LUE assessment which can provide important reference for management and precision agriculture.

  7. POZNAVANJE PLANETOV PRI UČENCIH NA RAZREDNI STOPNJI IZOBRAŽEVANJA

    Makovec, Julijana

    2009-01-01

    Namen raziskave je ugotoviti poznavanje planetov med učenci nižjih razredov osnovne šole. Zanimalo nas je, koliko učenci poznajo planete po imenu in kako jih prepoznajo na podlagi slikovnega gradiva. V nadaljevanju smo želeli raziskati predstave učencev o planetih in njihovih lastnostih. Pri tem nas je zanimalo, ali učenci poznajo velikosti planetov in razmere na njih in ali ločijo planete od zvezd in naravnih satelitov. Na koncu pa smo preverili še, kaj učenci vedo o opazovanju planetov. Ugo...

  8. Vías de señalización en enfermedades priónicas

    2007-01-01

    Las enfermedades priónicas, también conocidas como EETs (Encefalopatías Espongiformes Transmisibles), son un grupo de enfermedades neurodegenerativas fatales que, debido a su transmisibilidad potencial han tenido un gran impacto social, político y económico en las últimas décadas. Las EETs afectan a los humanos y a algunos grupos de animales, presentan largos períodos de incubación y producen la muerte pocos meses después de la aparición de la sintomatología clínica. Su origen se atribuye a ...

  9. Enfermedades priónicas: riesgos y medidas preventivas en Odontología

    2015-01-01

    El objetivo del presente trabajo es hacer una revisión de los últimos trabajos de investigación sobre las enfermedades priónicas para poder actualizar y transmitir información sobre las medidas de prevención y bioseguridad de estos agentes infecciosos no convencionales. Los priones son glucoproteínas situadas en las superficies celulares. Las versiones modificadas de los priones normales ocasionan enfermedades de progresión lenta, a menudo mortales del sistema nervioso central, una de las más...

  10. ZDRAVSTVENA NEGA IN PREHRANA BOLNIKA PRI KIRURŠKEM ZDRAVLJENJU TREBUŠNE SLINAVKE

    Lulik, Mateja

    2014-01-01

    Diplomsko delo je sestavljeno iz dveh delov. V medicinskem delu je opisana anatomija, fiziologija ter bolezni trebušne slinavke. Drugi del diplomskega dela predstavlja zdravstveno nego bolnika pri kirurškem zdravljenju trebušne slinavke ter najpogostejše negovalne diagnoze po operaciji. Opisana je tudi prehrana bolnika po operaciji, najpogostejša priporočila za prehrano bolnika na domu po odpustu iz bolnišnice ter po operaciji. Diplomsko delo s pomočjo domače, tuje literature in razpoložlj...

  11. Mobing kot motnja v komunikaciji pri delu in dejavnik duševnega zdravja dostojanstva posameznika

    Tičar, Luka

    2012-01-01

    Avtor opozarja na vsebinsko kompleksnost pojma mobing, pri čemer pa se v njegovo vsebino ne spušča, četudi je tesno in pomembno povezan s temeljno človekovo pravico do dostojanstva. Izhaja iz predpostavke, da mobing pomeni motnjo v komunikaciji med ljudmi in da je kot tak prej predmet socioloških in psiholoških znanstvenih razprav kot poglobljene pravne analize. Zato izpostavi zgolj eno opredelitev mobinga, z namenom, da bi seznanile bralca z njegovo osnovno vsebino. Pravno razpravo pa omeji ...

  12. Explaining the variability of Photochemical Reflectance Index (PRI): deconvolution of variability related to Light Use Efficiency and Canopy attributes.

    Merlier, Elodie; Hmimina, Gabriel; Dufrêne, Eric; Soudani, Kamel

    2014-05-01

    The Photochemical Reflectance Index (PRI) was designed as a proxy of the state of xanthophyll cycle which is used as a response of plants to excess of light (Gamon et al., 1990; 1992). Strong relationships between PRI and LUE were shown at leaf and canopy scales and over a wide range of species (Garbulsky et al., 2011). However, its use at canopy scale was shown to be significantly hampered by effects of confounding factors such as the PRI sensitivity to leaf pigment content (Gamon et al. 2001; Nakaji et al. 2006) and to canopy structure (Hilker et al. 2008). Several approaches aimed at correcting such effects and recent works focused on the deconvolution of LUE related and LUE unrelated PRI variability (Rahimzadeh-Bajgiran et al. 2012).In this study, the PRI variability at canopy scale is investigated over two years on three species (Fagus sylvatica, Quercus robur and Pinus sylvestris) growing under two water regimes. At daily scale, PRI variability is mainly explained by radiation conditions. As already reported at leaf scale in Hmimina et al. (2014), analysis of PRI responses to incoming photosynthetically active radiation over seasonal scale allowed to separate two sources of variability : a constitutive variability mainly related to canopy structure and leaf chlorophyll content and a facultative variability mainly related to LUE and soil moisture content. These results highlight the composite nature of PRI signal measured at canopy scale and the importance of disentangling its sources of variability in order to accurately assess ecosystem light use efficiency. Gamon JA, Field CB, Bilger W, Björkman O, Fredeen AL, Peñuelas J. 1990. Remote sensing of the xanthophyll cycle and chlorophyll fluorescence in sunflower leaves and canopies. Oecologia 85, 1-7. Gamon JA, Field CB, Fredeen A AL, Thayer S. 2001. Assessing photosynthetic downregulation in sunflower stands with an optically-based model. Photosynthesis Research 67, 113-125. Gamon JA, Peñuelas J, Field CB

  13. Attachment to Caregivers and Type 1 Diabetes in Children / Navezanost Na Starše in Sladkorna Bolezen Tipa 1 Pri Otrocih

    Drobnič Radobuljac Maja

    2015-03-01

    Full Text Available Navezanost je vedenjski in fiziološki sistem, ki posamezniku omogoča dinamično prilagajanje na okolje. Navezanost se razvija pri sovplivu med dojenčkom in materjo, igra pomembno vlogo pri razvoju otrokovih možgan in vpliva na kvaliteto posameznikovih socialnih odnosov vse življenje.

  14. La democracia fallida: la batalla de Carlos A. Madrazo por cambiar al PRI

    Ricardo Pozas-Horcasitas

    2008-03-01

    Full Text Available El artículo analiza la llegada de Carlos Alberto Madrazo al Comité Ejecutivo Nacional del Partido Revolucionario Institucional (PRI, y su intento por reformar al partido, introduciendo prácticas de selección a través de la elección directa de los representantes en el partido, así como en las candidaturas a los cargos de elección popular, reforma que confrontó la tradición de la autoridad política vertical y la designación de candidatos a cargos de elección en México.The article analyzes Carlos Alberto Madrazo's arrival at the National Executive Committee of the Institutional Revolutionary Party (PRI, the political environment of his arrival, his attempt to reform the party by introducing selection practices through the direct election of representatives in the party and candidacies for popularly-elected posts, a reform that challenged the tradition of vertical political authority and the designation of candidates toelected positions in Mexico.

  15. A pri-miR-218 variant and risk of cervical carcinoma in Chinese women

    Shi Ting-Yan

    2013-01-01

    Full Text Available Abstract Background MicroRNA (miRNA-related single nucleotide polymorphisms (SNPs may compromise miRNA binding affinity and modify mRNA expression levels of the target genes, thus leading to cancer susceptibility. However, few studies have investigated roles of miRNA-related SNPs in the etiology of cervical carcinoma. Methods In this case–control study of 1,584 cervical cancer cases and 1,394 cancer-free female controls, we investigated associations between two miR-218-related SNPs involved in the LAMB3-miR-218 pathway and the risk of cervical carcinoma in Eastern Chinese women. Results We found that the pri-miR-218 rs11134527 variant GG genotype was significantly associated with a decreased risk of cervical carcinoma compared with AA/AG genotypes (adjusted OR=0.77, 95% CI=0.63-0.95, P=0.015. However, this association was not observed for the miR-218 binding site SNP (rs2566 on LAMB3. Using the multifactor dimensionality reduction analysis, we observed some evidence of interactions of these two SNPs with other risk factors, especially age at primiparity and menopausal status, in the risk of cervical carcinoma. Conclusions The pri-miR-218 rs11134527 SNP was significantly associated with the risk of cervical carcinoma in Eastern Chinese women. Larger, independent studies are warranted to validate our findings.

  16. Assessing canopy PRI from airborne imagery to map water stress in maize

    Rossini, M.; Fava, F.; Cogliati, S.; Meroni, M.; Marchesi, A.; Panigada, C.; Giardino, C.; Busetto, L.; Migliavacca, M.; Amaducci, S.; Colombo, R.

    2013-12-01

    This paper presents a method for mapping water stress in a maize field using hyperspectral remote sensing imagery. An airborne survey using AISA (Specim, Finland) was performed in July 2008 over an experimental farm in Italy. Hyperspectral data were acquired over a maize field with three different irrigation regimes. An intensive field campaign was also conducted concurrently with imagery acquisition to measure relative leaf water content (RWC), active chlorophyll fluorescence (ΔF/Fm‧), leaf temperature (Tl) and Leaf Area Index (LAI). The analysis of the field data showed that at the time of the airborne overpass the maize plots with irrigation deficits were experiencing a moderate water stress, affecting the plant physiological status (ΔF/Fm‧, difference between Tl and air temperature (Tair), and RWC) but not the canopy structure (LAI). Among the different Vegetation Indices (VIs) computed from the airborne imagery the Photochemical Reflectance Index computed using the reflectance at 570 nm as the reference band (PRI570) showed the strongest relationships with ΔF/Fm‧ (r2 = 0.76), Tl - Tair (r2 = 0.82) and RWC (r2 = 0.64) and the red-edge Chlorophyll Index (CIred-edge) with LAI (r2 = 0.64). Thus PRI has been proven to be related to water stress at early stages, before structural changes occurred.

  17. Involvement of PI3-K in neuroprotective effects of the 1,25-dihydroxyvitamin D3 analogue - PRI-2191.

    Regulska, Magdalena; Leśkiewicz, Monika; Budziszewska, Bogusława; Kutner, Andrzej; Basta-Kaim, Agnieszka; Kubera, Marta; Jaworska-Feil, Lucylla; Lasoń, Władysław

    2006-01-01

    The active form of 1,25-dihydroxyvitamin D(3) prevents neuronal damage in vitro and in vivo , however, it induces also hypercalcemia and hyperphosphatemia. Side-chain-modified analogues of 1,25-dihydroxyvitamin D(3), which show low calcemic activity, may be potentially useful in the treatment of some neurodegenerative diseases. Previously, we have found that PRI-2191 more potently than 1,25-dihydroxyvitamin D(3) protects human neuroblastoma (SH-SY5Y) cells against hydrogen-peroxide-induced toxicity. In the present study, we evaluated effects of two other 1,25-dihydroxyvitamin D(3) analogues - PRI-1890 and PRI-1901 on the neuronal degeneration in the same cell model. In line with the previous study, 24-h incubation with hydrogen peroxide (0.5 mM) was toxic to cells, as evidenced by an enhanced efflux of lactate dehydrogenase into the culture medium, and these effects were prevented by PRI-1890 and PRI-1901 at concentration of 5, 50 and 500 nM. Comparing the neuroprotective effects of secosteroids, we found that all three analogues were efficient at lower concentration than 1,25-dihydroxyvitamin D(3) and among them the PRI-2191 showed the most evident concentration-dependent effect. In the second part of this study, an involvement of mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3-K), kinases which play a crucial role in neurodegenerative processes, in neuroprotective action of 1,25 dihydroxyvitamin D(3) and its the most potent analogue PRI-2191 has been investigated. The inhibitor of c-Jun N-terminal kinase (JNK)-MAPK (SP600125, 1 microM), inhibitor of p38-MAPK (SB-203580, 1 and 10 microM) and inhibitor of extracellular signal-regulated kinase (ERK)-MAPK (PD-98059, 15 and 30 microM) attenuated the hydrogen peroxide-induced toxicity. Moreover, PD-98059 (30 microM) enhanced neuroprotective effects of 1,25 dihydroxyvitamin D(3) but not that of PRI-2191. In contrast, the inhibitor of PI3-K (wortmannin, 10, 100 nM) did not affect hydrogen

  18. Explaining the variability of the photochemical reflectance index (PRI) at the canopy-scale: Disentangling the effects of phenological and physiological changes.

    Merlier, Elodie; Hmimina, Gabriel; Dufrêne, Eric; Soudani, Kamel

    2015-10-01

    Assessing photosynthesis rates at the ecosystem scale and over large regions is important for tracking the global carbon cycle and remote sensing has provided new and useful approaches for performing this assessment. The photochemical reflectance index (PRI) is a good estimator of short-term light-use efficiency (LUE) at the leaf scale; however, confounding factors appear at larger temporal and spatial scales. In this study, canopy-scale PRI variability was investigated for three species (Fagus sylvatica L., Quercus robur L. and Pinus sylvestris L.) growing under contrasting soil moisture conditions. Throughout the growing season, no significant differences in chlorophyll content and in violaxanthin, antheraxanthin and zeaxanthin were found between species or treatments. The daily PRI vs PAR (photosynthetically active radiation) relationships were determined using continuous measurements obtained at high frequency throughout the entire growing season, from early spring budburst to later autumn senescence, and were used to deconvolute the physiological PRI variability related to LUE variations due to phenological variability and related to temporal changes in the biochemical and structural canopy attributes. The PRI vs PAR relationship is used to show that the canopy-scale PRI measured at low radiation depends on the chlorophyll content of the canopy. The range of PRI variations at an intra-daily scale and the dynamics of the xanthophyll pool do not vary between days, which suggests that the PRI responds to a xanthophyll ratio. The PAR values at PRI saturation are mainly related to the canopy chlorophyll content during budburst and senescence and to the soil moisture content when the chlorophyll content is no longer a limiting factor. This parameter is significantly lower in the oak species that experience less stress from variations in soil moisture and is species dependant. These results provide new insights regarding the analysis and the meaning of PRI

  19. Demonstrating FLAVOUR: Friendly Location-aware conference Assistant with priVacy Observant architectURe (Demo Paper)

    Muthukrishnan, Kavitha; Meratnia, Nirvana; Koprinkov, Georgi; Lijding, Maria; Havinga, Paul

    2005-01-01

    In this paper, we describe an implementation of FLAVOUR (Friendly Location-aware conference Assistant with priVacy Observant architectURe), in which people/infrastructure resources act as individual service providers offering their location as a service. By subscribing to this service, in the one ha

  20. Association between pri-miR-218 polymorphism and risk of hepatocellular carcinoma in a Han Chinese population.

    Zhang, Lu-Shun; Liang, Wei-Bo; Gao, Lin-Bo; Li, Hong-Yu; Li, Li-Juan; Chen, Peng-Yu; Liu, Yun; Chen, Tian-Yi; Han, Jun-Ge; Wei, Yong-Gang; Zhang, Lin

    2012-05-01

    MicroRNAs are noncoding RNA molecules of 18-25 nucleotides that regulate gene expression at the post-transcriptional level. The aim of this study was to investigate whether pri-miR-218 rs11134527 A/G polymorphism influences the risk of hepatocellular carcinoma (HCC) or not. pri-miR-218 rs11134527 A/G was genotyped in 302 HCC patients and 513 control subjects using the polymerase chain reaction-restriction fragment length polymorphism assay. The AG genotype of pri-miR-218 rs11134527 A/G was associated with family history (p=0.018, odds ratio [OR]=2.96, 95% confidence interval [CI]: 1.16-7.56) and elevated serum α-fetoprotein (serum alpha-fetoprotein [AFP]) levels (≥20 ng/mL; p=0.009, OR=1.92, 95% CI: 1.17-3.14) in HCC patients. These findings suggested that the AG genotype of pri-miR-218 rs11134527 might relate to genetic predisposition and be involved in regulating the expression of AFP in Chinese HCC patients.

  1. Remote sensing of plant emissions of volatile isoprenoids with PRI. Prospects for upscaling (Invited)

    Penuelas, J.

    2013-12-01

    Josep Peñuelas*1,2, Giovanni Marino1,2,3,4, Joan LLusia1,2, Catherine Morfopoulos1,2,5, Gerard Farre-Armengol1,2, Shawn Kefauver, Alex Guenther6 , Francesca Rapparini7 , Roger Seco1,2,6, Marc Estiarte1,2, Mónica Mejia-Chang1,2, Romà Ogaya1,2, Jordi Sardans1,2 , Andrew Turnipseed6, Peter Harley6, Osvaldo Facini7, Rita Baraldi7, Jim Greenberg6 , Iolanda Filella1,2 1 CSIC, Global Ecology Unit CREAF-CEAB-UAB, Cerdanyola del Vallés 08193, Catalonia, Spain 2 CREAF, Cerdanyola del Vallés 08193, Catalonia, Spain 3 Dipartimento di Bioscienze e Territorio, Università degli Studi del Molise, Contrada Fonte Lappone, 86090 Pesche (IS), Italy 4 Institute for Plant Protection, National Research Council, Via Madonna del Piano 10, 50019 Sesto Fiorentino (FI), Italy 5 Division of Ecology and Evolution, Imperial College, Silwood Park, Ascot, SL5 7PY, UK 6 Atmospheric Chemistry Division, National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307-3000, USA 7 Biometeorology Institute, IBIMET-CNR, Via P. Gobetti 101, Bologna, Italy Abstract Terrestrial plants re-emit around 1-2% of the carbon they fix as isoprene and monoterpenes. These emissions play major roles in the ecological relationships among living organisms and in atmospheric chemistry and climate, and yet their actual quantification at the ecosystem level in different regions is far from being resolved. Phenomenological models are used to estimate the emission rates, but the limited understanding of the function and regulation of these emissions leads to large uncertainties in such estimations. Many measurements have been made at the foliar but few at the ecosystem level, and those that do exist are limited in space and time. We here provide evidence that a simple remote sensing index, the photochemical reflectance index (PRI), which is indicative of light use efficiency (LUE), is a good indirect estimator of foliar isoprenoid emissions and therefore can be used to sense them remotely. These results open

  2. The promoter of the pri-miR-375 gene directs expression selectively to the endocrine pancreas.

    Avnit-Sagi, Tali; Kantorovich, Lia; Kredo-Russo, Sharon; Hornstein, Eran; Walker, Michael D

    2009-01-01

    microRNAs (miRNAs) are known to play an essential role in controlling a broad range of biological processes including animal development. Accordingly, many miRNAs are expressed preferentially in one or a small number of cell types. Yet the mechanisms responsible for this selectivity are not well understood. The aim of this study was to elucidate the molecular basis of cell-specific expression of the pri-miR-375 gene, which is selectively expressed in pancreatic islets, and has been implicated both in the development of islets, and the function of mature pancreatic beta cells. An evolutionarily conserved 768 bp region of DNA upstream of the pri-miR-375 gene was linked to GFP and luciferase reporter genes, and expression monitored in transgenic mice and transfected cultured cells. Deletion and targeted mutagenesis analysis was used to evaluate the functional significance of sequence blocks within the upstream fragment. 5'-RACE analysis was used for mapping the pri-miR-375 gene transcription start site. The conserved 768 bp region was able to direct preferential expression of a GFP reporter gene to pancreatic islets in transgenic mice. Deletion analysis using a luciferase reporter gene in transfected cultured cell lines confirmed the cell specificity of the putative promoter region, and identified several key cis-elements essential for optimal activity, including E-boxes and a TATA sequence. Consistent with this, 5'-RACE analysis identified a transcription start site within this DNA region, 24 bp downstream of the TATA sequence. These studies define the promoter of the pri-miR-375 gene, and show that islet-specific expression of the pri-miR-375 gene is controlled at the transcriptional level. Detailed analysis of the transcriptional mechanisms controlling expression of miRNA genes will be essential to permit a comprehensive understanding of the complex role of miRNAs such as miR-375 in developmental processes.

  3. Razvoj odklanjala za rastrsko vodenje žarka pri laserskem označevanju

    Diaci, Janez; Babnik, Aleš; Bizjak, Aleš

    2015-01-01

    Prispevek predstavlja razvoj optomehatronskega sistema, ki omogoča izdelavo rastrskih vzorcev pri laserskem označevanju. Sistem deluje tako, da v eni osi odklanjamo obdelovalni laserski žarek s pomočjo poligonskega zrcala v obliki šesterokotne prizme, ki se vrti s konstantno kotno hitrostjo. Vsak laserski blisk povzroči na površini obdelovanca označbo v obliki točke. Z odklanjanjem žarka dosežemo, da so točkaste označbe razvrščene enakomerno v ravni črti - vrstici. Pomična miza, ki je pod odk...

  4. DIDAKTIČNE IGRE PRI POUKU SPOZNAVANJA OKOLJA ZUNAJ UČILNICE

    Majcen, Doroteja

    2014-01-01

    Didaktična igra se uporablja kot učna metoda, imeti mora vse lastnosti igre in dosegati določene (učne) cilje. Didaktična igra zunaj učilnice nudi učencu izkušnje in ob njej razvija pozitiven odnos do okolja in narave, kar je pri pouku spoznavanja okolja še posebej poudarjeno. V teoretičnem delu smo opredelili predmet spoznavanja okolja ter navedli didaktična priporočila za uresničevanje ciljev predmeta in vpeljevanje pouka spoznavanja okolja v naravo. Našteli in opisali smo didaktične strate...

  5. Patología del sueño en las enfermedades priónicas Sleep disorders in prion diseases

    2007-01-01

    Las enfermedades priónicas son un grupo de encefalopatías con cambios neurodegenerativos causados por una proteína alterada denominada prión cuyo dato característico es la transmisibilidad. Ocurren la mayoría de las veces de forma esporádica aunque un grupo de ellas son familiares asociadas a mutaciones en el gen de la proteína priónica. El polimorfismo genético parece determinar las diferentes variantes familiares. Una de las más enigmáticas e inhabituales es el Insomnio Letal Familiar (ILF)...

  6. PRI 3.1: Electrolyte membrane fuel cells (Co-PACEM), final report (july 2002 to june 2004); PRI 3.1: Coeurs de piles a combustible a electrolyte membrane (Co-PACEM), rapport final (juillet 2002 a juin 2004)

    Lamy, C.

    2004-07-01

    The researches realized in the PRI Co-PACEM aim to improve the operating of the core of the electrolyte membrane fuel cells, at low temperature in order to minimize the high voltage of the electro-chemical reactions, to decrease the cost of the membrane, to improve the properties (conductivity, mechanical and thermal stability...) and to optimize the transport of heat and reactive. The document presents the research programs. (A.L.B.)

  7. 一种 PRI 变化的雷达信号无源定位方法%A Passive Location Method of The Radar Signal with Variational PRI

    陈晓威; 李彦志; 张国毅

    2016-01-01

    目前脉冲重复间隔(PRI)恒定的雷达信号已经越来越少,取而代之的是PRI变化的雷达信号。传统的相位差变化率定位法均假设PRI恒定,没有考虑因PRI变化引起的相位差变化率测量误差和定位误差。提出了一种利用插值法重新构造相位差数据的方法,提取了相位差变化率并进行了定位解算。仿真结果表明采用该相位差数据重构方法能够实现快速高精度的无源定位。%Currently ,radar signal with constant pulse repetition interval (PRI) is less and less ,in-stead of this is radar signal with variational PRI .Traditional location method of phase difference change rate almost supposes that PRI is constant ,hasn't considered the measuring error of phase difference rate and position error due to the change of PRI .This paper puts forward a kind of meth-od to reconstruct phase difference data by means of interpolation method ,abstracts the phase difference rate and performs location calculation .T he simulation results show that the method to reconstruct phase difference data can quickly achieve passive location with high accuracy .

  8. Responses of the reflectance indices PRI and NDVI to experimental warming and drought in European shrublands along a north–south climatic gradient

    Mänd, Pille; Hallik, Lea; Peñuelas, Josep;

    2010-01-01

    canopy reflectance, effective green leaf area index (green LAIe) and chlorophyll fluorescence of dominant species. The treatment effects on green LAIe varied among sites. We calculated three reflectance indices: photochemical reflectance index PRI [531 nm; 570 nm], normalized difference vegetation index...... NDVI680 [780 nm; 680 nm] using red spectral region, and NDVI570 [780 nm; 570 nm] using the same green spectral region as PRI. All three reflectance indices were significantly related to green LAIe and were able to detect changes in shrubland vegetation among treatments. In general warming treatment...... in vegetation areas with low green LAIe. As both soil reflectance and LAI varied between northern and southern sites it is problematic to draw universal conclusions of climate-derived changes in all vegetation types based merely on PRI measurements. We propose that canopy level PRI measurements can be more...

  9. Neki problemi pri prevođenju moderne poezije promatrani kroz teoriju konceptualne integracije

    Sanja Cimer

    2011-12-01

    Full Text Available Straußeneimondaber ich finde nichts mehrnichts mehr an Buchstaben im Wortmache so ähnlichwie Luftgang ohne Seiles fällt nichts mehraber nichts ist eben auchZaungrenzeund LebenMittelstelzengangder Strauß legt seine Eier in den Himmelfast Massenproduktionkugelrunde Stundenmit Haut auf wirren ÜberzugHände greifen leerwenn nicht duaber das kann nicht –Angsttauchen mit Höhengangund die Hand als Schalewer fängt, – verliert!Mjesec od nojevog jajetaali nema ničeg višeničeg više u slovima riječičinim sličnokao hod po zraku bez konopcaništa više ne padaali i ništa jestgranica od ogradei životsredinom na štulamanoj liježe svoja jaja u nebogotovo masovna proizvodnjasati okrugli poput loptes kožom na neurednoj presvlaciruke posežu u praznoako nisi tiali to ne može –uron u strah s letom u visinei ruka poput ljusketko ulovi, – izgubi!Prevođenje poezije oduvijek se smatralo osobitom temom unutar ionako složenog područja književnog prevođenja. Budući da poezija predstavlja književni oblik u kojem su sadržaj i forma nerazdvojno povezani, jasno je zašto ona predstavlja najzahtjevniji oblik prevoditeljske aktivnosti. Problematičnu točku pri prevođenju poezije predstavlja činjenica da ona daje izrazito “zgusnutu” i kompaktnu formu te da jezik poezije uglavnom počiva na konotacijama, a ne na denotacijama. Noviji pristupi prevođenju prepoznaju da su nekadašnja protivljenja prevođenju poezije, to jest isticanja njezine neprevodivosti, zapravo bila usmjerena na nemogućnost potpunog prenošenja svih aspekata izvornog poetskog djela u ciljni jezik i njegovu kulturu i tradiciju (neprevodivost poezije isticali su, primjerice, T. S. Eliott: “[poezija je] stalni podsjetnik na sve ono što se može reći samo na jednom jeziku”, Roman Jakobson: “poezija je po definiciji neprevodiva” ili Nabokov: “pjesma ne može biti prevedena, reproducirana ni iznova oblikovana na ciljnom jeziku” (svi navedeni citati te citati

  10. ¿Por qué perdió el PRI en Yucatán? Las transiciones de este año en bastiones priístas, caída de una imagen distorsionada

    Lic. Fernando Pacheco Bailón

    2001-01-01

    Full Text Available El pasado domingo 27 de mayo, a eso de las 5:30 de la tarde, los mexicanos nos enteramos a través de los medios de comunicación de televisión abierta y pagada de la ventaja que tenía el candidato a la gubernatura de Yucatán, a través de la coalición PAN, PRD, PVEM, PT, Patricio Patrón Laviada, con respecto al candidato del PRI, Orlando Paredes Lara. Más tarde, de aquella llamada telefónica que hiciera el presidente Vicente Fox para felicitar al candidato que aventajaba al del tricolor, al hacer referencia a las encuestas de salida llevadas a cabo por empresas como Consulta Mitovsky, Garo y otras más. Hay muchas metodologías para poder analizar procesos electorales, así como distintas formas de abordar el problema del por qué perdió el PRI en Yucatán. Para efectos de estudio se planteará las condiciones preelectorales que se dieron, el propio momento electoral del pasado 27 de mayo, así como la visión futura de PRI como organización política en tiempos transitorios.

  11. New high spin states and isomers in the {sup 208}Pb and {sup 207}Pb nuclei

    Broda, R.; Wrzesinski, J.; Pawlat, T. [and others

    1996-12-31

    The two most prominent examples of the heavy doubly closed shell (DCS) nuclei, {sup 208}Pb and {sup 132}Sn, are not accessible by conventional heavy-ion fusion processes populating high-spin states. This experimental difficulty obscured for a long time the investigation of yrast high-spin states in both DCS and neighboring nuclei and consequently restricted the study of the shell model in its most attractive regions. Recent technical development of multidetector gamma arrays opened new ways to exploit more complex nuclear processes which populate the nuclei of interest with suitable yields for gamma spectroscopy and involve population of moderately high spin states. This new possibility extended the range of accessible spin values and is a promising way to reach new yrast states. Some of these states are expected to be of high configurational purity and can be a source of important shell model parameters which possibly can be used later to check the validity of the spherical shell model description at yet higher spin and higher excitation energy. The nuclei in the closest vicinity of {sup 132}Sn are produced in spontaneous fission and states with spin values up to I=14 can be reached in fission gamma spectroscopy studies with the presently achieved sensitivity of gamma arrays. New results on yrast states in the {sup 134}Te and {sup 135}I nuclei populated in fission of the {sup 248}Cm presented at this conference illustrate such application of the resolving power offered by modern gamma techniques.

  12. Pri I J K(介绍国际青年世界语者大会)

    王瑞祥

    1994-01-01

    ■irkaǔ160 esperantistoj el 33 landoj kun granda entuziasmo partoprenis en la 49-a Interna-cia Junulara Kongreso(IJK) de la 7-a ■is la 14-a de aǔgusto 1993 en la urbo Vraca, Bulgario.La inaǔguro okazis en la Urba Artgalerio. Aliaj kunvenoj estis aran■itaj en apudurba univer-sitata kvartalo, kie la ■eestantoj ankaǔ lo■is. Tage,LKK organizis interesajn programerojn laǔ lagustoj de la junuloj. Estis diskuto pri la modernaj tendencoj en Esperanto-Komunumo, prelegoj dela"kongresa universitato", renkonti■oj de redaktoroj de junularaj gazetoj kaj de partopernantoj deIJK en la jaro 1963, kiu okazis ankaǔ en Vraca, diversaj kursoj, forumo pri Bulgario, internaci-aj ekzamenoj de UEA/ILEI kaj pluraj Esperant-lingvaj videofilm-prezentoj. Interalie, la revuo

  13. PRI变换法用于信号分选的性能研究%Research on performance of PRI transform in signal sorting

    张什永; 张海黎; 徐龙; 胡泽宾

    2012-01-01

    Since it can suppress PRI harmonics efficiently,PRI transform,a DTOA-based algorithm,is widely researched in radar signal sorting.Phase factor is firstly discussed,and its effect in PRI spectrum accumulating is revealed;then both the limitations of PRI transform and its adapted PRI types are analyzed theoretically.Finally,the performance of PRI transform to real signal environment is given by computer simulations.Both theoretical analysis and simulation results can be used as engineering reference.%PRI变换是一种基于脉冲到达时间的信号分选方法,由于该算法能够有效抑制真实PRI的谐波,近年来受到越来越多的关注。首先讨论了相位因子的作用,揭示了相位因子是进行变换谱峰值累积的关键;接着通过理论分析指出了PRI变换法的局限和适用的PRI类型;最后仿真分析了该方法对分选过程所面临的信号环境的适应性。理论及仿真分析结果可作为工程应用的参考依据,具有一定的实用价值。

  14. Promotion of cortico-cerebral precursors expansion by artificial pri-miRNAs targeted against the Emx2 locus.

    Diodato, Assunta; Pinzan, Moira; Granzotto, Marilena; Mallamaci, Antonello

    2013-04-01

    Emx2 encodes for a transcription factor controlling several aspects of cerebral cortex development. Its overexpression promotes self-renewal of young cortico-cerebral precursors, it promotes neuronal rather than gliogenic fates and it protects neuronal progenitors from cell death. These are all key activities for purposes of gene-promoted brain repair. Artificial pri-miRNAs targeting non-coding cis-active modules and/or conserved sequences of the Emx2 locus were delivered to embryonic cortico-cerebral precursors, by lentiviral vectors. A subset of these pri-miRNAs upregulated Emx2, possibly stimulating its transcription. That led to enhanced self-renewal, delayed differentiation and reduced death of neuronally committed precursors, resulting in an appreciable expansion of the neuronogenic precursors pool. This method makes Emx2 overexpression for purposes of brain repair a more feasible goal, avoiding the drawbacks of exogenous gene copies introduction. Interestingly, the two genomic enhancers targeted by these pri-miRNAs were discovered to be naturally transcribed. Their expression profile suggests their possible involvement in regulation of Emx2 transcription.

  15. Blocking the maturation of OncomiRNAs using pri-miRNA-17∼92 aptamer in retinoblastoma.

    Subramanian, Nithya; Kanwar, Jagat R; Kanwar, Rupinder K; Krishnakumar, Subramanian

    2015-02-01

    The miR-17∼92. or oncomiR-1, cluster encodes oncogenic microRNAs (miRNAs), and it also promotes retinoblastoma (RB) tumor formation. Antagomir and miRNA mimics based approaches are widely tried against oncogenic and tumor suppressive miRNAs. Other methods for targeting cancer related miRNAs are still under development. In the current study, we focused on the pri-miRNA-17∼92 aptamer (pri-apt), which can potentially replace the mix of five antagomirs by one aptamer that function to abrogate the maturation of miR-17, miR-18a, and miR-19b (Ppri-apt led to S-phase arrest in WERI-Rb1 cells and onset of apoptosis in both Y79 and WERI-Rb1 cell lines. There was increased cytotoxicity as measured by lactate dehydrogenase activity in pri-apt treated Y79 cells (Ppri-apt in RB cell lines, which can be readily modified by developing appropriate vectors for the delivery of the aptamer specifically to cancer cells.

  16. Role of pri-miRNA tertiary structure in miR-17~92 miRNA biogenesis.

    Chaulk, Steven G; Thede, Gina L; Kent, Oliver A; Xu, Zhizhong; Gesner, Emily M; Veldhoen, Richard A; Khanna, Suneil K; Goping, Ing Swie; MacMillan, Andrew M; Mendell, Joshua T; Young, Howard S; Fahlman, Richard P; Glover, J N Mark

    2011-01-01

    MicroRNAs (miRNAs) regulate gene expression in a variety of biological pathways such as development and tumourigenesis. miRNAs are initially expressed as long primary transcripts (pri-miRNAs) that undergo sequential processing by Drosha and then Dicer to yield mature miRNAs. miR-17~92 is a miRNA cluster that encodes 6 miRNAs and while it is essential for development it also has reported oncogenic activity. To date, the role of RNA structure in miRNA biogenesis has only been considered in terms of the secondary structural elements required for processing of pri-miRNAs by Drosha. Here we report that the miR-17~92 cluster has a compact globular tertiary structure where miRNAs internalized within the core of the folded structure are processed less efficiently than miRNAs on the surface of the structure. Increased miR-92 expression resulting from disruption of the compact miR-17~92 structure results in increased repression of integrin α5 mRNA, a known target of miR-92a. In summary, we describe the first example of pri-miRNA structure modulating differential expression of constituent miRNAs.

  17. Pri-miR-17-92a transcript folds into a tertiary structure and autoregulates its processing.

    Chakraborty, Saikat; Mehtab, Shabana; Patwardhan, Anand; Krishnan, Yamuna

    2012-05-01

    MicroRNAs control gene expression either by RNA transcript degradation or translational repression. Expressions of miRNAs are highly regulated in tissues, disruption of which leads to disease. How this regulation is achieved and maintained is still largely unknown. MiRNAs that reside on clustered or polycistronic transcripts represent a more complex case where individual miRNAs from a cluster are processed with different efficiencies despite being cotranscribed. To shed light on the regulatory mechanisms that might be operating in these cases, we considered the long polycistronic primary miRNA transcript pri-miR-17-92a that contains six miRNAs with diverse functions. The six miRNA domains on this cluster are differentially processed to produce varying amounts of resultant mature miRNAs in different tissues. How this is achieved is not known. We show, using various biochemical and biophysical methods coupled with mutational studies, that pri-miR-17-92a adopts a specific three-dimensional architecture that poses a kinetic barrier to its own processing. This tertiary structure could create suboptimal protein recognition sites on the pri-miRNA cluster due to higher-order structure formation.

  18. siRNA release from pri-miRNA scaffolds is controlled by the sequence and structure of RNA.

    Galka-Marciniak, Paulina; Olejniczak, Marta; Starega-Roslan, Julia; Szczesniak, Michal W; Makalowska, Izabela; Krzyzosiak, Wlodzimierz J

    2016-04-01

    shmiRs are pri-miRNA-based RNA interference triggers from which exogenous siRNAs are expressed in cells to silence target genes. These reagents are very promising tools in RNAi in vivo applications due to their good activity profile and lower toxicity than observed for other vector-based reagents such as shRNAs. In this study, using high-resolution northern blotting and small RNA sequencing, we investigated the precision with which RNases Drosha and Dicer process shmiRs. The fidelity of siRNA release from the commonly used pri-miRNA shuttles was found to depend on both the siRNA insert and the pri-miR scaffold. Then, we searched for specific factors that may affect the precision of siRNA release and found that both the structural features of shmiR hairpins and the nucleotide sequence at Drosha and Dicer processing sites contribute to cleavage site selection and cleavage precision. An analysis of multiple shRNA intermediates generated from several reagents revealed the complexity of shmiR processing by Drosha and demonstrated that Dicer selects substrates for further processing. Aside from providing new basic knowledge regarding the specificity of nucleases involved in miRNA biogenesis, our results facilitate the rational design of more efficient genetic reagents for RNAi technology.

  19. A competitive regulatory mechanism discriminates between juxtaposed splice sites and pri-miRNA structures.

    Mattioli, Chiara; Pianigiani, Giulia; Pagani, Franco

    2013-10-01

    We have explored the functional relationships between spliceosome and Microprocessor complex activities in a novel class of microRNAs (miRNAs), named Splice site Overlapping (SO) miRNAs, whose pri-miRNA hairpins overlap splice sites. We focused on the evolutionarily conserved SO miR-34b, and we identified two indispensable elements for recognition of its 3' splice site: a branch point located in the hairpin and a downstream purine-rich exonic splicing enhancer. In minigene systems, splicing inhibition owing to exonic splicing enhancer deletion or AG 3'ss mutation increases miR-34b levels. Moreover, small interfering-mediated silencing of Drosha and/or DGCR8 improves splicing efficiency and abolishes miR-34b production. Thus, the processing of this 3' SO miRNA is regulated in an antagonistic manner by the Microprocessor and the spliceosome owing to competition between these two machineries for the nascent transcript. We propose that this novel mechanism is commonly used to regulate the relative amount of SO miRNA and messenger RNA produced from primary transcripts.

  20. mirEX: a platform for comparative exploration of plant pri-miRNA expression data.

    Bielewicz, Dawid; Dolata, Jakub; Zielezinski, Andrzej; Alaba, Sylwia; Szarzynska, Bogna; Szczesniak, Michal W; Jarmolowski, Artur; Szweykowska-Kulinska, Zofia; Karlowski, Wojciech M

    2012-01-01

    mirEX is a comprehensive platform for comparative analysis of primary microRNA expression data. RT-qPCR-based gene expression profiles are stored in a universal and expandable database scheme and wrapped by an intuitive user-friendly interface. A new way of accessing gene expression data in mirEX includes a simple mouse operated querying system and dynamic graphs for data mining analyses. In contrast to other publicly available databases, the mirEX interface allows a simultaneous comparison of expression levels between various microRNA genes in diverse organs and developmental stages. Currently, mirEX integrates information about the expression profile of 190 Arabidopsis thaliana pri-miRNAs in seven different developmental stages: seeds, seedlings and various organs of mature plants. Additionally, by providing RNA structural models, publicly available deep sequencing results, experimental procedure details and careful selection of auxiliary data in the form of web links, mirEX can function as a one-stop solution for Arabidopsis microRNA information. A web-based mirEX interface can be accessed at http://bioinfo.amu.edu.pl/mirex.

  1. 耐辐射球菌中priA类似基因突变对DNA修复和DNA转化的影响%EFFECT OF priA like GENE MUTATION ON DNA REPAIR AND DNA TRANSFORMATION OF Deinococcus radiodurans

    王媛; 华跃进

    2012-01-01

    Replication fork progression can be blocked easily by DNA damage. Damaged DNA repair and the subsequent restart of the stalled or collapsed replication forks are critical for cell survival. The PriA-dependent pathway is the major replication restart mechanism in bacteria. To understand the roles of a priA-like gene (Dr2606) in Deinococcus radiodurans and DNA repair, a Dr2606 null mutant was constructed by replacing Dr2606 open reading frame with a kanamycin-resistanee gene and treated the Dr2606 mutant with UV and mitomycin C (MMC), and the DNA transformation efficiency of the Dr2606 mutant was also tested. Successively, the Dr2606 mutant showed a delayed growth and a dramatic decrease of cell viability. Unexpectedly, the DNA repair capability of D. radiodurans was not impaired by the inactivation of Dr2606. However, the DNA transformation efficiency was largely compromised in the mutant. These results indicate that the priA-like gene (Dr2606) is dispensable for stalled DNA replication forks restart in D. radiodurans and origin-independent replication restart in D. radiodurans may be different from other bacteria.%DNA损伤很易阻断复制叉的前进。损伤DNA的修复以及接下来停止复制叉的重启动过程对细胞生存极为重要。依赖于PriA的复制重启动机制是细菌复制重启动的主要途径。为了解priA类似基因Dr2606在耐辐射球菌中的作用,并检测Dr2606在DNA修复中的作用,本研究用卡那霉素抗性基因代替Dr2606阅读框,构建了Dr2606缺失突变株,并对突变株进行UV和丝裂霉素处理,测定了Dr2606突变株的转化效率。Dr2606的突变导致菌体生长缓慢,细胞生存率急剧下降。意外的是,耐辐射球菌的DNA修复能力没有削弱。但突变株的转化效率大大削弱。这说明在耐辐射球菌中priA类似基因Dr2606对停止复制叉的重启动过程并不是必需的;耐辐射球菌不依赖于原点的复制重启动过程可能与其他细菌不同。

  2. 基于PRI变换法的脉冲信号分选算法%Pulse Signals De-interleaving Algorithm Based on PRI Transform

    乔宏乐; 王超; 王鹏

    2012-01-01

    脉冲重复间隔是电子对抗中信号分选的关键参数,本文研究的基于PRI变换法的信号分选算法克服了传统直方图统计法的子谐波问题,对脉冲重复间隔具有很高的估计精度,且具有很好的抗抖动性能。仿真分析表明,PRI变换法对固定PRI,抖动PRI具有很好的估计效果。%The pulse repetition interval (PRI) is a key parameter of radar signal de-interleaving in the field of elec-tronic countermeasures. The signal de-interleaving algorithm based on PRI transform overcomes the sub-harmonic problem produced in the histogram statistical method and can estimate the PRI with high precision, and possesses perfect anti - dithering capability. The simulated results indicate that PRI transform algorithm can estimate effect on fixed PRI and dithering PRI.

  3. The in-vitro antiproliferative effect of PRI-2191 and imatinib applied in combined treatment with cisplatin, idarubicin, or docetaxel on human leukemia cells.

    Switalska, Marta; Nasulewicz-Goldeman, Anna; Opolska, Aleksandra; Maciejewska, Magdalena; Kutner, Andrzej; Wietrzyk, Joanna

    2012-01-01

    Imatinib mesylate (Gleevec, STI571) is a specific inhibitor of the Bcr/Abl fusion tyrosine kinase that exhibits potent antileukemic effects in chronic myelogenous leukemia. Bcr/Abl-positive K562 and Bcr/Abl-negative HL-60 human leukemia cells were used to investigate the effect of PRI-2191, a calcitriol analog, on the biological effects of imatinib combined with other anticancer drugs. The results show that PRI-2191 enhances the antiproliferative effect of imatinib on HL-60 cells. When these two agents together are applied with either docetaxel or cisplatin, but not with idarubicin, the antiproliferative effect could still be enhanced. Moreover, when the interaction between the chemotherapy agents was antagonistic or additive, PRI-2191 could even shift it to synergism. This effect correlated with an accumulation of HL-60 cells in the G0/G1 phase of the cell cycle and a decrease in the percentage of cells in the G2/M and S stage in the ternary combinations used. PRI-2191 did not influence apoptosis induced by imatinib alone or in ternary combinations with all the chemotherapy agents used. These results may suggest that the stronger antiproliferative effect of the combined treatment with PRI-2191 on HL-60 cells is related to cell cycle arrest rather than to the induction of apoptosis.

  4. No association of pri-miR-143 rs41291957 polymorphism with the risk of congenital heart disease in a Chinese population.

    Yang, Liping; Gao, Xiaobo; Luo, Haiyan; Huang, Qiuyu; Wei, Ying; Zhang, Guican; Huang, Guoying; Su, Dongmei; Chen, Liangwan; Lu, Cailing; Yang, Juhua; Ma, Xu

    2014-08-01

    MiR-143 plays an important role in the heart development of zebra fish. The rs41291957 variant located in the pri-miR-143 sequence is associated with colorectal carcinogenesis. Therefore, the authors hypothesized that rs41291957 in pri-miR-143 might be involved in the risk of sporadic congenital heart disease (CHD). The authors conducted a case-control study of CHD in a Chinese population to test their hypothesis by genotyping pri-miR-143 rs41291957 in 1,109 CHD cases and 915 non-CHD control subjects. Logistic regression analyses showed no significant association of genotype or allele frequencies of pri-miR-143 rs41291957 A/G polymorphism with the CHD cases in overall or various subtypes compared with the control group. To the authors' knowledge, this is the first study to investigate the relationship between miR-143 and CHD cases. The results demonstrated that rs41291957 in pri-miR-143 has no major role in genetic susceptibility to sporadic CHD, at least in the current study population.

  5. Transcriptional, post-transcriptional and chromatin-associated regulation of pri-miRNAs, pre-miRNAs and moRNAs

    Nepal, Chirag; Coolen, Marion; Hadzhiev, Yavor;

    2015-01-01

    MicroRNAs (miRNAs) play a major role in the post-transcriptional regulation of target genes, especially in development and differentiation. Our understanding about the transcriptional regulation of miRNA genes is limited by inadequate annotation of primary miRNA (pri-miRNA) transcripts. Here, we...... used CAGE-seq and RNA-seq to provide genome-wide identification of the pri-miRNA core promoter repertoire and its dynamic usage during zebrafish embryogenesis. We assigned pri-miRNA promoters to 152 precursor-miRNAs (pre-miRNAs), the majority of which were supported by promoter associated post....... Developmental profiling revealed a subset of pri-miRNAs that are maternally inherited. Moreover, we show that promoter-associated H3K4me3, H2A.Z and RNAPII marks are not only present at pri-miRNA promoters but are also specifically enriched at pre-miRNAs, suggesting chromatin level regulation of pre...

  6. PRI-CAT: a web-tool for the analysis, storage and visualization of plant ChIP-seq experiments.

    2011-01-01

    Although several tools for the analysis of ChIP-seq data have been published recently, there is a growing demand, in particular in the plant research community, for computational resources with which such data can be processed, analyzed, stored, visualized and integrated within a single, user-friendly environment. To accommodate this demand, we have developed PRI-CAT (Plant Research International ChIP-seq analysis tool), a web-based workflow tool for the management and analysis of ChIP-seq ex...

  7. Approach to Radar Signal Clustering Based on PRI Entropy%基于PRI熵的雷达信号聚类方法研究

    孙盼杰; 刘刚; 王杰

    2008-01-01

    针对脉冲分选聚类中存在的问题,引入熵的概念,定义了 PRI(脉冲重复间隔)熵,给出了雷达脉冲序列之间合并的 PRI 熵判据.并在此基础上提出了新的雷达信号聚类方法.采用先分选后合并的思路,通过计算合并前后 PRI 熵是否减小来判断是否对序列合并.通过仿真验证该方法解决增批问题的有效性.

  8. Transcriptional, post-transcriptional and chromatin-associated regulation of pri-miRNAs, pre-miRNAs and moRNAs.

    Nepal, Chirag; Coolen, Marion; Hadzhiev, Yavor; Cussigh, Delphine; Mydel, Piotr; Steen, Vidar M; Carninci, Piero; Andersen, Jesper B; Bally-Cuif, Laure; Müller, Ferenc; Lenhard, Boris

    2016-04-20

    MicroRNAs (miRNAs) play a major role in the post-transcriptional regulation of target genes, especially in development and differentiation. Our understanding about the transcriptional regulation of miRNA genes is limited by inadequate annotation of primary miRNA (pri-miRNA) transcripts. Here, we used CAGE-seq and RNA-seq to provide genome-wide identification of the pri-miRNA core promoter repertoire and its dynamic usage during zebrafish embryogenesis. We assigned pri-miRNA promoters to 152 precursor-miRNAs (pre-miRNAs), the majority of which were supported by promoter associated post-translational histone modifications (H3K4me3, H2A.Z) and RNA polymerase II (RNAPII) occupancy. We validated seven miR-9 pri-miRNAs by in situ hybridization and showed similar expression patterns as mature miR-9. In addition, processing of an alternative intronic promoter of miR-9-5 was validated by 5' RACE PCR. Developmental profiling revealed a subset of pri-miRNAs that are maternally inherited. Moreover, we show that promoter-associated H3K4me3, H2A.Z and RNAPII marks are not only present at pri-miRNA promoters but are also specifically enriched at pre-miRNAs, suggesting chromatin level regulation of pre-miRNAs. Furthermore, we demonstrated that CAGE-seq also detects 3'-end processing of pre-miRNAs on Drosha cleavage site that correlates with miRNA-offset RNAs (moRNAs) production and provides a new tool for detecting Drosha processing events and predicting pre-miRNA processing by a genome-wide assay.

  9. Pri-let-7a-1 rs10739971 polymorphism is associated with gastric cancer prognosis and might affect mature let-7a expression.

    Li, Ying; Xu, Qian; Liu, Jingwei; He, Caiyun; Yuan, Quan; Xing, Chengzhong; Yuan, Yuan

    2016-01-01

    The relationship between the pri-let-7a-1 rs10739971 polymorphism and gastric cancer (GC) risk has been reported. However, the role of this polymorphism in the prognosis of GC remains largely elusive. Sequenom MassARRAY platform method and the polymerase chain reaction (PCR)-restriction fragment length polymorphism were used to investigate pri-let-7a-1 rs10739971 G→A in 334 GC patients. Real-time PCR detected expression of mature let-7a in serum and tissue. Patients with AA or GA+AA genotypes of the pri-let-7a-1 rs10739971 polymorphism demonstrated significantly longer survival time than those with the wild GG genotype. Stratified analysis indicated that survival time was significantly longer in women with AA or GA+AA genotypes and in Borrmann type I/II patients with GA heterozygote or GA+AA genotypes. AA genotype was more frequent in the lymphatic-metastasis-negative subgroup. Serum mature let-7a expression in healthy people with the GA heterozygote and the GA+AA genotype was higher than in those with the GG genotype, and the difference remained significant in the female healthy subgroup. Pri-let-7a-1 rs10739971 polymorphism might be a biomarker for GC prognosis, especially for female and Borrmann type I/II patients. The pri-let-7a-1 rs10739971 polymorphism might affect serum mature let-7a expression, and partly explain the mechanism of the relationship between the pri-let-7a-1 rs10739971 polymorphism and GC survival.

  10. A novel method for the modulation type recognition of radar PRI%雷达PRI调制样式识别新方法

    陈晟; 姜秋喜; 潘继飞

    2012-01-01

    Aiming at the shortcoming of the modulation type recognition of radar PRI,five classsified parameters which can effectively describe the modulation characteristics of radar PRI are given based on the analysis of radar PRI types,and the management methods for the missing and spurious pulsesv are analyzed.On these grounds,the recognition arithmetic and realized process for the modulation types of radar PRI are put forword and be used to effectively recognize five representative PRI modulation types.Theoretic analysis and computer simulation indicate that this method is robust in the presence of a low PRI measurement precision and a high rate of missing and spuriou pulses.%针对雷达PRI调制样式识别难题,在分析雷达PRI类型的基础上,提出了能够有效描述雷达PRI调制特征的五种分类特征参数,分析了对存在丢失和虚假脉冲的处理方法,并据此提出了PRI调制样式的识别算法与实现流程,实现了五种典型PRI调制样式的有效识别。理论分析与计算机仿真结果表明,该方法在PRI测量精度较低和丢失虚假脉冲比例较高的情况下具有稳健的识别性能。

  11. Prediction of moment-rotation characteristic of top- and seat-angle bolted connection incorporating prying action

    Ahmed, Ali

    2017-02-01

    Finite element (FE) analyses were performed to explore the prying influence on moment-rotation behaviour and to locate yielding zones of top- and seat-angle connections in author's past research studies. The results of those FE analyses with experimental failure strategies of the connections were used to develop failure mechanisms of top- and seat-angle connections in the present study. Then a formulation was developed based on three simple failure mechanisms considering bending and shear deformations, effects of prying action on the top angle and stiffness of the tension bolts to estimate rationally the ultimate moment M u of the connection, which is a vital parameter of the proposed four-parameter power model. Applicability of the proposed formulation is assessed by comparing moment-rotation (M-θ r ) curves and ultimate moment capacities with those measured by experiments and estimated by FE analyses and three-parameter power model. This study shows that proposed formulation and Kishi-Chen's method both achieved close approximation driving M-θ r curves of all given connections except a few cases of Kishi-Chen model, and M u estimated by the proposed formulation is more rational than that predicted by Kishi-Chen's method.

  12. Improved RT-PCR Assay to Quantitate the Pri-, Pre-, and Mature microRNAs with Higher Efficiency and Accuracy.

    Tong, Li; Xue, Huihui; Xiong, Li; Xiao, Junhua; Zhou, Yuxun

    2015-10-01

    Understanding of the functional significance of microRNAs (miRNAs) requires efficient and accurate detection method. In this study, we developed an improved miRNAs quantification system based on quantitative real-time polymerase chain reaction (qRT-PCR). This method showed higher efficiency and accuracy to survey the expression of primary miRNAs (pri-miRNAs), precursor miRNAs (pre-miRNAs), and mature miRNAs. Instead of relative quantification method, we quantified the pri-miRNAs and pre-miRNAs with absolute qRT-PCR based on SYBR Green I fluorescence. This improvement corrected for the inaccuracy caused by the differences in amplicon length and PCR efficiency. We also used SYBR Green method to quantify mature miRNAs based on the stem-loop qRT-PCR method. We extended the pairing part of the stem-loop reverse transcript (RT) primer from 6 to 11 bp, which greatly increased the efficiency of reverse transcription PCR (RT-PCR). The performance of the improved RT primer was tested using synthetic mature miRNAs and tissue RNA samples. Results showed that the improved RT primer demonstrated dynamic range of seven orders of magnitude and sensitivity of detection of hundreds of copies of miRNA molecules.

  13. 叶片光化学植被指数(PRI)的修正及其敏感性分析%Sensitivity Study of a Revised Leaf Photochemical Reflectance Index(PRI)

    吴朝阳; 牛铮; 汤泉

    2008-01-01

    光化学植被指数(PRI)被成功的应用于估算不同叶片生化组分的光能利用率(LUE),这些生化组分包括叶片含水量、氮元素浓度等.以往的研究中已经成功建立了叶片、冠层和景观尺度PRI和LUE的相关关系.但是,为了利用PRI更加准确地估算叶片LUE,很多问题仍然亟需解决,比如当LUE高于0.03 molCO2 mol-1PPFD(photosynthetic photon flux density),PRI会出现一个明显的饱和区域以及PRI和LUE关系会随季节发生较大变化.文章对PRI进行了修正,并基于PROSPECT模型对这一修正形式进行了4个参数的敏感性分析.分析结果表明,叶片SR-PRI(Simple ratio PRI)对叶肉结构参数(N)、叶绿素浓度(Cab)敏感性要高于叶片的等效水厚(Cw)和干物质浓度(Cm).因此叶肉结构参数(N)和叶绿素浓度(Cab)的微小变化都会造成SR-PRI的较大变化,进而影响到LUE的估算精度.对SR-PRI的实证实验表明,这一指数也能够很好地用来估算叶片的光能利用率并且结果要优于PRI和LUE之间的相关关系.SR-PRI最重要的一方面在于其更清晰的物理意义和对531 nm处反射率变化的敏感性,因为这一波段位置的反射率变化是评价光能利用率的核心参数.

  14. The Effects of Utilization of PRI/RS on Reading Achievement in the Oklahoma City Public Schools. Evaluation of 1981-82.

    Kimball, George H.

    1982-01-01

    A study was conducted to determine (1) the extent to which the degree of use of PRI/RS (the Prescriptive Reading Inventory Reading Systems, a criterion referenced management system developed by CTB/McGraw Hill) affected comparable groups of students on standardized achievement measures; (2) whether the degree of use differentially influenced…

  15. Inhibition of hepatitis B virus replication by helper dependent adenoviral vectors expressing artificial anti-HBV pri-miRs from a liver-specific promoter.

    Mowa, Mohube Betty; Crowther, Carol; Ely, Abdullah; Arbuthnot, Patrick

    2014-01-01

    Research on applying RNA interference (RNAi) to counter HBV replication has led to identification of potential therapeutic sequences. However, before clinical application liver-specific expression and efficient delivery of these sequences remain an important objective. We recently reported short-term inhibition of HBV replication in vivo by using helper dependent adenoviral vectors (HD Ads) expressing anti-HBV sequences from a constitutively active cytomegalovirus (CMV) promoter. To develop the use of liver-specific transcription regulatory elements we investigated the utility of the murine transthyretin (MTTR) promoter for expression of anti-HBV primary microRNAs (pri-miRs). HD Ads containing MTTR promoter effected superior expression of anti-HBV pri-miRs in mice compared to HD Ads containing the CMV promoter. MTTR-containing HD Ads resulted in HBV replication knockdown of up to 94% in mice. HD Ads expressing trimeric anti-HBV pri-miRs silenced HBV replication for 5 weeks. We previously showed that the product of the codelivered lacZ gene induces an immune response, and the duration of HBV silencing in vivo is likely to be attenuated by this effect. Nevertheless, expression of anti-HBV pri-miRs from MTTR promoter is well suited to countering HBV replication and development of HD Ads through attenuation of their immunostimulatory effects should advance their clinical utility.

  16. 基于PRI谱的双门限雷达信号分选算法及其硬件平台设计%Double-Threshold PRI Sorting Algorithm Based on PRI Spectrum and Its Sorting Platform Design

    柴娟芳; 司锡才; 马晓东

    2009-01-01

    针对修正的PRI变换法无法分选重频参差雷达信号的缺点,提出了一种基于PRI谱的双门限雷达信号分选算法.该算法先对PRI谱设定双门限检测各个准PRI,再结合组合查看及序列搜索提取各个PRI.同时,构建了一种预分选、主分选结合的新型分选平台.预分选利用带有PowerPC的FPGA构架片上系统,完成对脉冲雷达信号的实时测量、AOA分类及数据存储;主分选采用DSP专职完成其他维参数的分选算法.谊分选新算法在保留抑制PRI子谐波优点的同时,对重频固定、抖动和参差的雷达脉冲信号都有较好的检测结果.视频信号源的大量测试表明,谊分选平台对普通雷达、PRI抖动和参差雷达、频率捷变雷达及一些特殊雷达均具有较好的分选能力.

  17. The interaction effects of pri-let-7a-1 rs10739971 with PGC and ERCC6 gene polymorphisms in gastric cancer and atrophic gastritis.

    Qian Xu

    Full Text Available BACKGROUND: The aim of this study was to investigate the interaction effects of pri-let-7a-1 rs10739971 with pepsinogen C (PGC and excision repair cross complementing group 6 (ERCC6 gene polymorphisms and its association with the risks of gastric cancer and atrophic gastritis. We hoped to identify miRNA polymorphism or a combination of several polymorphisms that could serve as biomarkers for predicting the risk of gastric cancer and its precancerous diseases. METHODS: Sequenom MassARRAY platform method was used to detect polymorphisms of pri-let-7a-1 rs10739971 G → A, PGC rs4711690 C → G, PGC rs6458238 G → A, PGC rs9471643 G → C, and ERCC6 rs1917799 in 471 gastric cancer patients, 645 atrophic gastritis patients and 717 controls. RESULTS: An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (P interaction = 0.026; and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (P interaction = 0.012 and PGC rs9471643 polymorphism (P interaction = 0.039 were observed for the risk of atrophic gastritis. CONCLUSION: The combination of pri-let-7a-1 rs10739971 polymorphism and ERCC6 and PGC polymorphisms could provide a greater prediction potential than a single polymorphism on its own. Large-scale studies and molecular mechanism research are needed to confirm our findings.

  18. Functional study of one nucleotide mutation in pri-miR-125a coding region which related to recurrent pregnancy loss.

    Hu, Yi; Huo, Zheng-Hao; Liu, Chun-Mei; Liu, Shi-Guo; Zhang, Ning; Yin, Kun-Lun; Qi, Lu; Ma, Xu; Xia, Hong-Fei

    2014-01-01

    MicroRNAs (miRNAs) are short non-coding RNAs which modulate gene expression by binding to complementary segments present in the 3'UTR of the mRNAs of protein coding genes. MiRNAs play very important roles in maintaining normal human body physiology conditions, meanwhile, abnormal miRNA expressions have been found related to many human diseases spanning from psychiatric disorders to malignant cancers. Recently, emerging reports have indicated that disturbed miRNAs expression contributed to the pathogenesis of recurrent pregnancy loss (RPL). In this study, we identified a new mutation site (+29A>G, position relative to pre-miR-125a) by scanning pri-miR-125a coding region in 389 Chinese Han RPL patients. This site was co-existed with two polymorphisms (rs12976445 and rs41275794) in patients heterogeneously and changed the predicted secondary structures of pri-miR-125a. Subsequent in vitro analysis indicated that the A>G mutation reduced mature miR-125a expression, and further led to less efficient inhibition of verified target genes. Functional analysis showed that mutant pri-mir-125a can enhance endometrial stromal cells (ESCs) invasive capacity and increase the sensitivity of ESCs cells to mifepristone. Moreover, we further analyzed the possible molecular mechanism by RIP-chip assay and found that mutant pri-mir-125a disturbed the expression of miR-125a targetome, the functions of which includes embryonic development, cell proliferation, migration and invasion. These data suggest that A>G mutation in pri-miR-125a coding region contributes to the genetic predisposition to RPL by disordering the production of miR-125a, which consequently meddled in gene regulatory network between mir-125a and mRNA.

  19. Method of deinterleaving radar signal based on PRI transform algorithm%一种基于PRI变换的雷达信号分选方法

    王海滨; 马琦

    2013-01-01

    With the signal environment of information warfare increasingly complicated, the radar signal sorting technology, as one of development directions of modern radar, is of great importance to radar reconnaissance. Several radar signal deinterleav-ing methods are proposed based on PRI parameter. The traditional PRI transform can overcome the subharmonic problem pro-duced in the histogram statistic methods, but has a poor performance on anti-jitter. The paper begins with a discussion of the im-proved PRI transform which overcomes the disadvantages of traditional PRI method effectively, followed by the description of the algorithm simulation. Finally, a method for sorting pulse repetition intervals of staggered PRI is discussed.%信息作战环境日益复杂,而雷达信号分选技术是作为现代信息对抗领域的重要发展方向之一,对于雷达侦察非常重要.对于雷达信号分选,基于PRI参数提出了很多分选方法.传统的PRI变换能克服直方图统计法中的子谐波问题,但抗抖动性差.讨论了修正的PRI变换分选算法,有效地克服了传统PRI变换的缺点,并对算法进行了计算机仿真.最后还讨论了重频参差抖动脉冲序列的分选方法.

  20. NON-GENICULATE CORALLINE ALGAE (CORALLINALES, RHODOPHYTA FROM THE LOWER OLIGOCENE OF POLJŠICA PRI PODNARTU (NORTHERN SLOVENIA

    LUKA GALE

    2009-03-01

    Full Text Available Despite their increasing importance in sedimentology and palaeoecology, non-geniculate coralline algae remain virtually overlooked in Slovenia. Though these plants are present or even abundant in the Cretaceous and Cainozoic strata, they have never been studied in detail with notable exception of corallines from the Lower Oligocene beds in the area of Gornji Grad. Poljšica pri Podnartu is another locality where Lower Oligocene beds are exposed, considered as equivalent to the former. The studied profile consists of pebbly limestone, mudstone, sandstone and limestone. Limestones contain abundant non-geniculate coralline algae. Nine species from six genera of these corallines have been identified: Lithoporella melobesioides (Foslie Foslie, 1909, Neogoniolithon contii (Mastrorilli Quaranta et al., 2007, Spongites sp., Lithothamnion sp. 1, Lithothamnion sp. 2, Mesophyllum sp. 1, Mesophyllum sp. 2, Mesophyllum sp. 3 and Sporolithon sp. Some of these species are described from Slovenia for the first time. 

  1. Protein kinase C α regulates nuclear pri-microRNA 15a release as part of endothelin signaling.

    von Brandenstein, Melanie; Depping, Reinhard; Schäfer, Ekaterine; Dienes, Hans-Peter; Fries, Jochen W U

    2011-10-01

    Endothelin-1 induced signaling is characterized by an early induction of a nuclear factor-kappa B p65/mitogen-activated phosphokinase p38 transcription complex via its A-receptor versus a late induction via diacylglycerol, and protein kinase C. A possible interaction between these two pathways and a potential function for protein kinase C in this context has not previously been elucidated. Here we report that in Caki-1 tumor cells, protein kinase C α is a part of the transcription complex. With importin α4 and α5 as chaperones, the transcription complex transmigrates into the nucleus. Protein kinase C α blocks the nuclear release of pri-microRNA 15a by direct binding shown by electrophoretic mobility shift assay and Duolink immune histology. The expression levels of miRNA 15a can be further manipulated by transfection of si-protein kinase C α, or an expression vector containing protein kinase C α or miRNA 15. The miRNA 15a regulation by protein kinase C α is detectable in different malignant human tumor cell lines (renal cell carcinoma, breast carcinoma, and melanoma). Furthermore, all three cell lines harbor both endothelin receptors (ETAR/ETBR). Specific blockage of each receptor leads to major reduction of miRNA 15a expression due to increased nuclear protein kinase C α translocation. We conclude that the nuclear binding of pri-microRNA 15a is a novel function of protein kinase C α, which plays an important role in endothelin-1 mediated signaling. Since several endothelin-sensitive, malignant tumor cell lines harbor this regulation, it could indicate a more general role in tumor biology.

  2. Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3'-UTR, influence susceptibility to gastric cancer.

    Arisawa, Tomiyasu; Tahara, Tomomitsu; Shiroeda, Hisakazu; Matsue, Yasuhito; Minato, Takahiro; Nomura, Tomoe; Yamada, Hideto; Hayashi, Ranji; Saito, Takashi; Matsunaga, Kazuhiro; Fukuyama, Tomoki; Hayashi, Nobuhiko; Otsuka, Toshimi; Fukumura, Atsushi; Nakamura, Masakatsu; Shibata, Tomoyuki

    2012-07-01

    We report an association between gastric cancer (GC) and polymorphisms in IL17A, rs2275913 (-197 G > A), rs3748067 (*1249 C > T), and pri-miR-938, rs2505901 (T > C). We employed the multiplex PCR-SSCP method to detect gene polymorphisms in 337 GC cases and 587 controls. The minor allele frequency of rs2275913 was significantly higher, and those of rs3748067 and rs2505901 significantly lower, in GC cases than controls. The rs2275913 AA homozygote was associated with an increased risk (OR, 2.38; 95%CI, 1.63-3.46; p pri-miR-938 contribute to cancer risk susceptibility and therefore can affect the development of gastric cancer.

  3. Identification and analysis of genetic variations in pri-miRNAs expressed specifically or at a high level in sheep skeletal muscle.

    Wei Zhang

    Full Text Available MicroRNAs (miRNAs are key regulators in miRNA-mediated gene regulatory networks and play important roles in many biological processes, such as growth and development of mammals. In this study, we used microarrays to detect 261 miRNAs that are expressed in sheep skeletal muscle. We found 22 miRNAs that showed high levels of expression and equated to 89% of the total miRNA. Genetic variations in these 22 pri-miRNAs were further investigated using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP and sequencing. A total of 49 genetic variations, which included 41 single nucleotide polymorphisms (SNPs and 8 deletions/insertions, were identified in four sheep breeds. Three variations were further researched in a larger sample set, including five sheep breeds with different meat production performances. We found that the genotype and allele frequencies of the CCC deletion/insertion in pri-miR-133a were significantly related to the sheep meat production trait. Finally, cell assays and quantitative reverse transcription PCR (qRT-PCR were employed to investigate the effect of pri-miRNA genetic variation on the miRNA biogenesis process. The results confirmed that genetic variations can influence miRNA biogenesis and increase or decrease the levels of mature miRNAs, in accordance with the energy and stability change of hair-pin secondary structures. Our findings will help to further the understanding of the functions of genetic variations in sheep pri-miRNAs in skeletal muscle growth and development.

  4. Prion-like nanofibrils of small molecules (PriSM): A new frontier at the intersection of supramolecular chemistry and cell biology

    Zhou, Jie; Du, Xuewen; Xu, Bing

    2015-01-01

    Formed by non-covalent interactions and not defined at genetic level, the assemblies of small molecules in biology are complicated and less explored. A common morphology of the supramolecular assemblies of small molecules is nanofibrils, which coincidentally resembles the nanofibrils formed by proteins such as prions. So these supramolecular assemblies are termed as prion-like nanofibrils of small molecules (PriSM). Emerging evidence from several unrelated fields over the past decade implies ...

  5. Endocrine and Metabolic Effects of Adipose Tissue in Children and Adolescents / Endokrina in Presnovna Funkcija Maščobnega Tkiva Pri Otrocih in Mladostnikih

    Kotnik Primož

    2015-03-01

    Full Text Available Maščobno tkivo ima vlogo pri številnih endokrinih in presnovnih procesih. Lepin je bil med prvimi odkritimi dejavniki iz maščobnega tkiva, ki delujejo avto-, para- in endokrino. Od opredelitve leptina so odkrili še številne druge dejavnike, od katerih se nekateri izločajo iz maščobnih celic, nekateri pa iz drugih celic maščobnega tkiva.

  6. 基于PRI的脉冲序列去交错方法%PRI-Based Algorithms for Deinterleaving of Radar Pulses

    周斌

    2002-01-01

    论述使用脉冲重复间隔(PRI)对雷达脉冲去交错的算法,分析PRI变换算法并对算法进行计算机仿真.对PRI变换算法进行改进,并对改进算法进行了计算机仿真和分析.

  7. Pri-miR-34b/c rs4938723 TC heterozygote is associated with increased cancer risks: evidence from published data.

    Yi, De-Hui; Wang, Ben-Gang; Zhong, Xin-Ping; Liu, Hao; Liu, Yong-Feng

    2014-12-01

    The promoter region of the microRNA pri-miR-34b/c has a potentially functional polymorphism, rs4938723, located in a typical CpG island. Studies of the association between pri-miR-34b/c rs4938723 polymorphism and risks of various cancers have had inconsistent results. We therefore conducted a meta-analysis of nine studies that included 6,036 cancer patients and 7,490 controls to address this association. Overall, this meta-analysis showed the pri-miR-34b/c rs4938723 TC heterozygote to be significantly associated with increased risk of overall cancers compared with the wild-type TT genotype (P = 0.010, odds ratio (OR) = 1.10, 95 % confidence interval (CI) 1.02-1.18). In stratified analysis, the TC heterozygote was significantly associated with increased cancers risks in digestive tract cancers, in hepatocellular cancer, in Asian population and in the large-sample subgroup. The CC genotypes of rs4938723 were also associated with increased hepatocellular cancer risk but associated with decreased colorectal cancer risk in the stratification analysis by a single cancer type. Thus our meta-analysis suggests that the pri-miR-34b/c rs4938723 TC heterozygote contributes to increased overall cancer risks, as well as shown in digestive tract cancers, in hepatocellular cancer, in Asian population and in the large-sample subgroup. This rs4938723 SNP showed an opposite tendency orientation between the hepatocellular cancer and colorectal cancer risks. Large-sample studies are needed to verify our findings.

  8. Identification and analysis of genetic variations in pri-miRNAs expressed specifically or at a high level in sheep skeletal muscle.

    Zhang, Wei; Wang, Limin; Zhou, Ping; Song, Guangchao; Shen, Min; Gan, Shangquan; Shi, Guoqing

    2015-01-01

    MicroRNAs (miRNAs) are key regulators in miRNA-mediated gene regulatory networks and play important roles in many biological processes, such as growth and development of mammals. In this study, we used microarrays to detect 261 miRNAs that are expressed in sheep skeletal muscle. We found 22 miRNAs that showed high levels of expression and equated to 89% of the total miRNA. Genetic variations in these 22 pri-miRNAs were further investigated using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and sequencing. A total of 49 genetic variations, which included 41 single nucleotide polymorphisms (SNPs) and 8 deletions/insertions, were identified in four sheep breeds. Three variations were further researched in a larger sample set, including five sheep breeds with different meat production performances. We found that the genotype and allele frequencies of the CCC deletion/insertion in pri-miR-133a were significantly related to the sheep meat production trait. Finally, cell assays and quantitative reverse transcription PCR (qRT-PCR) were employed to investigate the effect of pri-miRNA genetic variation on the miRNA biogenesis process. The results confirmed that genetic variations can influence miRNA biogenesis and increase or decrease the levels of mature miRNAs, in accordance with the energy and stability change of hair-pin secondary structures. Our findings will help to further the understanding of the functions of genetic variations in sheep pri-miRNAs in skeletal muscle growth and development.

  9. Single-nucleotide polymorphism of the pri-miR-34b/c gene is not associated with susceptibility to congenital heart disease in the Han Chinese population.

    Liu, Y-M; Wang, Y; Peng, W; Wu, Z; Wang, X-H; Wang, M-L; Wang, W; Sun, J; Zhang, Z-D; Mo, X-M

    2013-08-12

    Recent evidence has shown that the microRNA polymorphism may play an important role in the susceptibility to congenital heart disease (CHD). A potentially functional SNP rs4938723 (T>C) in the promoter region of pri-miR-34b/c might affect transcription factor GATA binding and therefore pri-miR-34b/c expression. We genotyped the pri-miR-34b/c polymorphism in a case-control study of 590 patients and 672 controls in a Han Chinese population and assessed the effects of the pri-miR-34b/c polymorphism on CHD susceptibility by TaqMan SNP genotyping assay. There was no association between the pri-miR-34b/c polymorphism and the risk of CHD in both genotype and allelic frequency. In a subsequent analysis of the association between this polymorphism and CHD classification, there was still no significant difference in both genotype and allelic frequency. Our results suggest that the pri-miR-34b/c polymorphism rs4938723 is not associated with susceptibility to sporadic CHD in the Han Chinese population.

  10. Zeaxanthin-independent energy quenching and alternative electron sinks cause a decoupling of the relationship between the photochemical reflectance index (PRI) and photosynthesis in an evergreen conifer during spring.

    Fréchette, Emmanuelle; Wong, Christopher Y S; Junker, Laura Verena; Chang, Christine Yao-Yun; Ensminger, Ingo

    2015-12-01

    In evergreen conifers, the winter down-regulation of photosynthesis and its recovery during spring are the result of a reorganization of the chloroplast and adjustments of energy-quenching mechanisms. These phenological changes may remain undetected by remote sensing, as conifers retain green foliage during periods of photosynthetic down-regulation. The aim was to assess if the timing of the spring recovery of photosynthesis and energy-quenching characteristics are accurately monitored by the photochemical reflectance index (PRI) in the evergreen conifer Pinus strobus. The recovery of photosynthesis was studied using chlorophyll fluorescence, leaf gas exchange, leaf spectral reflectance, and photosynthetic pigment measurements. To assess if climate change might affect the recovery of photosynthesis, seedlings were exposed to cold spring conditions or warm spring conditions with elevated temperature. An early spring decoupling of the relationship between photosynthesis and PRI in both treatments was observed. This was caused by differences between the timing of the recovery of photosynthesis and the timing of carotenoid and chlorophyll pool size adjustments which are the main factors controlling PRI during spring. It was also demonstrated that zeaxanthin-independent NPQ mechanisms undetected by PRI further contributed to the early spring decoupling of the PRI-LUE relationship. An important mechanism undetected by PRI seems to involve increased electron transport around photosystem I, which was a significant energy sink during the entire spring transition, particularly in needles exposed to a combination of high light and cold temperatures.

  11. Application of carbon nanosorbent for PRiME pass-through cleanup of 10 selected local anesthetic drugs in human plasma samples.

    Ma, Jian-Bo; Zhao, Li-Ming; Rui, Qiu-Hong; Liao, Yu-Feng; Chen, Yan-Min; Xu, Jin; Zhu, Yan; Zhao, Yong-Gang

    2017-04-01

    A novel PRiME (process, robustness, improvements, matrix effects, ease of use) pass-through cleanup procedure has been developed to improve the existing commercially available designs. Carbon nanosorbents, i.e., magnetic modified carboxyl-graphene (Mag-CG) and magnetic modified carboxyl-carbon nanotubes (Mag-CCNTs), have been synthesised and evaluated in PRiME pass-through cleanup procedure for human plasma prior to analysis of 10 selected local anesthetic drugs by liquid chromatography-tandem quadrupole mass spectrometry (LC-MS/MS). The matrix effect, an interesting phenomenon of ion suppression for local anesthetic drugs containing ester group and ion enhancement for other drugs containing acylamino group, has been minimized using carbon nanosorbents PRiME pass-through cleanup procedure. Under the optimal conditions, the obtained results show higher cleanup efficiency of the carbon nanosorbents with recoveries between 70.2% and 126%. Furthermore, the carbon nanosorbents are also evaluated for reuse up to 80-100 times. The limits of quantification (LOQs) for local anesthetic drugs are in the range of 0.024-0.15 μg/L. Validation results on linearity, specificity, accuracy, and precision, as well as the application to the analysis of lidocaine in five patients recruited from the lung cancer demonstrate the applicability to clinical studies.

  12. The impact of pri-miR-218 rs11134527 on the risk and prognosis of patients with esophageal squamous cell carcinoma.

    Jiang, Lin; Wang, Chaofu; Sun, Canlin; Xu, Yumin; Ding, Zhongqi; Zhang, Xueling; Huang, Junxing; Yu, Hong

    2014-01-01

    MicroRNA-218 (miR-218) acts as a tumor suppressor in numerous types of cancer by regulation of the expression of target genes. The aim of this study was to investigate whether polymorphisms in miR-218 LAMB3 pathway were associated with the risk and prognosis of esophageal squamous cell carcinoma (ESCC). Pri-mir-218 rs11134527 and LAMB3 rs2566 were genotyped in ESCC patients and 745 controls to assess their associations with cancer risk and overall survival. Pri-mir-218 rs11134527 was significantly associated with a decreased risk of ESCC under codominant, recessive and additive models. Although there was a significant association between rs11134527 and better survival of ESCC patients under codominant, recessive and additive models, the association disappeared after adjustment for TNM and LNM. However, further stratified analysis revealed that the association remained significant in patients with TNM stages I and II or non-LNM. Our data suggest that pri-miR-218 rs11134527 may contribute to the genetic susceptibility and prognosis for ESCC in Chinese Han population.

  13. Magnetic and electric behavior of praseodymium substituted CuPryFe2-yO4 ferrites

    Farid, Muhammad Tahir; Ahmad, Ishtiaq; Kanwal, Muddassara; Murtaza, Ghulam; Ali, Irshad; Ashiq, Muhammad Naeem; Khan, Sajjad Ahmad

    2017-01-01

    Spinel ferrites with chemical formula CuPryFe2-yO4(y=0.0,0.02,0.04,0.06,0.08,0.10) were synthesized using sol-gel technique. The sintered powder characterized by X-ray diffraction (XRD), Scanning Electron Microscopy (SEM) and vibrating sample magnetometer (VSM). X-ray Diffraction analysis showed that the samples with concentration (y=0.0-0.06) have single spinel phase and the samples with concentration at y=0.08-0.10 have secondary phase (ortho ferrite phase) along spinel phase. The Lattice constant a increased with the substitution of Praseodymium (Pr) ions. The crystallite size calculated from Scherre's formula is found in the range of 53-37 nm. It is observed that DC resistivity and activation energy enhances with the substitution of Pr. The dc resistivity decreased with the increase in temperature. The conduction below Curie temperature (Tc) is due to hopping of electrons and holes, whereas, above Curie temperature it is due to polaron hopping. The decrease in Tc with increasing Pr constant may be due to the fact that Pr-Fe interactions on the B sites are weaker than Fe-Fe interaction. The saturation magnetization (Ms) and remanence (Mr) decreased where as coercivity (Hc) has been increased with the increase of Pr content. The measured parameters suggest that these materials are potential candidates for high frequency applications.

  14. Pri-miR-34b/c rs4938723 polymorphism contributes to acute lymphoblastic leukemia susceptibility in Chinese children.

    Tong, Na; Chu, Haiyan; Wang, Meilin; Xue, Yao; Du, Mulong; Lu, Lingling; Zhang, Heng; Wang, Feng; Fang, Yongjun; Li, Jie; Wu, Dongmei; Zhang, Zhengdong; Sheng, Xiaojing

    2016-01-01

    A polymorphism rs4938723 (T > C) within the promoter region of pri-miR-34b/c has been found to not only affect the expression of mature miR-34b/c but also contribute to the susceptibility to several cancer types. We designed a case-control study to evaluate the role of rs4938723 in childhood acute lymphoblastic leukemia (ALL). The rs4938723 CC genotype was significantly associated with reduced ALL risk (p = 0.003, ORadjusted = 0.51, 95% CI = 0.33-0.80 for CC vs. TT). Stratification analyses showed the differences were pronounced in older (> 6 years), male subjects, as well as in patients in low risk and T-ALL subtypes. The in vitro luciferase assays in Jurkat and K-562 cell lines showed that the transcription activity of miR-34b/c was increased when T allele transited to C allele (p < 0.05). In conclusion, rs4938723 genetic variant contributed to the susceptibility to Chinese childhood ALL by influencing the transcription activity of miR-34b/c promoter.

  15. 206Pb-230Th-234U-238U and 207Pb-235U geochronology of Quaternary opal, Yucca Mountain, Nevada

    Neymark, Leonid A.; Amelin, Yuri V.; Paces, James B.

    2000-01-01

    U–Th–Pb isotopic systems have been studied in submillimeter-thick outermost layers of Quaternary opal occurring in calcite–silica fracture and cavity coatings within Tertiary tuffs at Yucca Mountain, Nevada, USA. These coatings preserve a record of paleohydrologic conditions at this site, which is being evaluated as a potential high-level nuclear waste repository. The opal precipitated from groundwater is variably enriched in 234U (measured 234U/238U activity ratio 1.124–6.179) and has high U (30–313 ppm), low Th (0.008–3.7 ppm), and low common Pb concentrations (measured 206Pb/204Pb up to 11,370). It has been demonstrated that the laboratory acid treatment used in this study to clean sample surfaces and to remove adherent calcite, did not disturb U–Th–Pb isotopic systems in opal. The opal ages calculated from 206Pb∗/238U and 207Pb∗/235U ratios display strong reverse discordance because of excess radiogenic 206Pb∗ derived from the elevated initial 234U. The data are best interpreted using projections of a new four-dimensional concordia diagram defined by 206Pb∗/238U, 207Pb∗/235U, 234U/238Uactivity, and 230Th/238Uactivity. Ages and initial 234U/238U activity ratios have been calculated using different projections of this diagram and tested for concordance. The data are discordant, that is observed 207Pb∗/235U ages of 170 ± 32 (2σ) to 1772 ± 40 ka are systematically older than 230Th/U ages of 34.1 ± 0.6 to 452 ± 32 ka. The age discordance is not a result of migration of uranium and its decay products under the open system conditions, but a consequence of noninstantaneous growth of opal. Combined U–Pb and 230Th/U ages support the model of slow mineral deposition at the rates of millimeters per million years resulting in layering on a scale too fine for mechanical sampling. In this case, U–Pb ages provide more accurate estimates of the average age for mixed multiage samples than 230Th/U ages, because ages based on shorter-lived isotopes are nonlinearly biased by younger mineral additions. Use of the combined U–Th–Pb technique to date Yucca Mountain Quaternary opals significantly extends the age range beyond that of the 230Th/U dating method and shows that selected fracture pathways in the unsaturated zone felsic tuffs of Yucca Mountain have been active throughout the Quaternary.

  16. A New Algorithm of PRI Transform%一种新的PRI变换分选算法

    李英达; 肖立志; 于洋; 康一丁; 王宇

    2014-01-01

    脉冲重复间隔(pulse repetition interval,PRI)变换及其改进算法是雷达信号分选领域的经典算法之一.在早期的信号环境中,各部雷达信号的PRI值相对接近,传统的改进PRI变换算法能够有效地分选PRI抖动雷达信号,因而得到了广泛的应用.随着信号环境的日益复杂,不同雷达发射的信号其PRI值分布在一个较大的范围内,此时传统算法的分选能力大大减弱.针对上述问题,对传统算法中可变时间起点的改变、PRI箱的选择以及门限的确定三个方面进行改进,提出一种新的PRI变换分选算法.新算法中采用了可变的移动因子、固定的箱分辨率以及合理的门限,在保留原算法优点的同时,能够适应PRI值分布在较大范围内的抖动雷达信号分选问题,并通过模拟仿真验证了算法的有效性.

  17. Characterization of Staphylococcus aureus Primosomal DnaD Protein: Highly Conserved C-Terminal Region Is Crucial for ssDNA and PriA Helicase Binding but Not for DnaA Protein-Binding and Self-Tetramerization.

    Yen-Hua Huang

    Full Text Available The role of DnaD in the recruitment of replicative helicase has been identified. However, knowledge of the DNA, PriA, and DnaA binding mechanism of this protein for the DnaA- and PriA-directed replication primosome assemblies is limited. We characterized the DNA-binding properties of DnaD from Staphylococcus aureus (SaDnaD and analyzed its interactions with SaPriA and SaDnaA. The gel filtration chromatography analysis of purified SaDnaD and its deletion mutant proteins (SaDnaD1-195, SaDnaD1-200 and SaDnaD1-204 showed a stable tetramer in solution. This finding indicates that the C-terminal region aa 196-228 is not crucial for SaDnaD oligomerization. SaDnaD forms distinct complexes with ssDNA of different lengths. In fluorescence titrations, SaDnaD bound to ssDNA with a binding-site size of approximately 32 nt. A stable complex of SaDnaD1-195, SaDnaD1-200, and SaDnaD1-204 with ssDNA dT40 was undetectable, indicating that the C-terminal region of SaDnaD (particularly aa 205-228 is crucial for ssDNA binding. The SPR results revealed that SaDnaD1-195 can interact with SaDnaA but not with SaPriA, which may indicate that DnaD has different binding sites for PriA and DnaA. Both SaDnaD and SaDnaDY176A mutant proteins, but not SaDnaD1-195, can significantly stimulate the ATPase activity of SaPriA. Hence, the stimulation effect mainly resulted from direct contact within the protein-protein interaction, not via the DNA-protein interaction. Kinetic studies revealed that the SaDnaD-SaPriA interaction increases the Vmax of the SaPriA ATPase fivefold without significantly affecting the Km. These results indicate that the conserved C-terminal region is crucial for ssDNA and PriA helicase binding, but not for DnaA protein-binding and self-tetramerization.

  18. pri-miR-21重组腺病毒载体构建及其对TLR4基因调控的研究%Construction of a recombined adenovirus vector carrying pri-miR-21 gene and research on it's target gene TLR4

    赵婧; 徐广贤; 贾伟; 董辉; 张一琳; 赵志军; 魏军

    2012-01-01

    目的:构建能高效表达成熟miR-21小分子的腺病毒载体,探讨其对TLR4基因的靶向调控关系.方法:以正常小鼠基因组DNA为模板,PCR扩增pri-miR-21基因,克隆至穿梭载体pAdTrack-CMV中经PCR、酶切及基因测序分析正确无误后,与pAdEasy-1腺病毒骨架质粒进行同源重组,并利用293A细胞,包装成pri-miR-21重组腺病毒感染HeLa细胞,通过Westem blot检测TLR4的蛋白表达水平,验证miR-21与TLR4靶向调控的关系.结果:经PCR、酶切、测序及GFP表达证实,成功构建携带pri-miR-21基因的重组腺病毒载体并制备出高滴度重组病毒.Western blot证实,miR-21可抑制TLR4蛋白的表达.结论:所制备的小鼠pri- miR-21重组腺病毒,可以高效表达成熟miR-21小分子,能够抑制靶基因TLR4的表达.%AIM: To construct the recombined adenovi-rus vector carrying pri-miR-21 gene, which can express mature miR-21 efficiently, and to study the interaction of miR-21 with its target gene TLR4. METHODS: Using healthy mouse's gDNA as template, the primary miR-21 coding sequence was amplified by PCR and cloned into a shuttle vector pAdTrack-CMV. Constructed plasmid was sequenced and linearized for homologous recombination with pAdEasy-1 vector in BJ5183 bacteria. The recombined adenovirus vector carrying pri-miR-21 gene was used to challenge HeLa cell. The candidate target gene of miR-21 was determined by miRNA analysis databases. The expression level of TLR4 protein was detected by western blotting. RESULTS; Through the PCR, restriction enzyme digestion, DNA sequencing and expression of GFP, recombinant adenoviral vector pri-miR-21 gene was constructed successfully. Bioin-formatic analysis suggested a few possible binding sites between miR-21 and TLR4. Results showed that miR-21 down-regulated TLR4 at protein levels. CONCLUSION-. The recombinant adenoviral vector containing pri- miR-21 was successfully constructed. miR-21 gene interfered with the expression of TLR4 target gene.

  19. Improvement of the design and generation of highly specific plant knockdown lines using primary synthetic microRNAs (pri-smiRNAs

    Alves Leonardo

    2010-03-01

    Full Text Available Abstract Background microRNAs (miRNAs are endogenous small non-coding RNAs that post-transcriptionally regulate gene expression. In plants, they typically show high complementarity to a single sequence motif within their target mRNAs and act by catalyzing specific mRNA cleavage and degradation. miRNAs are processed from much longer primary transcripts via precursor miRNAs containing fold-back structures. Leaving these secondary structures intact, miRNAs can be re-designed experimentally to target mRNAs of choice. Results We designed primary synthetic miRNAs (pri-smiRNAs on the basis of the primary transcript of the Arabidopsis MIR159A gene by replacing the original miR159a and the corresponding miR159a* with novel sequences, keeping the overall secondary structure as predicted by the program RNAfold. We used the program RNAhybrid to optimize smiRNA design and to screen the complete Arabidopsis transcriptome for potential off-targets. To improve the molecular cloning of the pri-smiRNA we inserted restriction sites in the original MIR159A primary transcript to easily accommodate the smiRNA/smiRNA* DNA fragment. As a proof-of-concept, we targeted the single gene encoding chalcone synthase (CHS in Arabidopsis. We demonstrate smiRNA(CHS expression and CHS mRNA cleavage in different transgenic lines. Phenotypic changes in these lines were observed for seed color and flavonol derivatives, and quantified with respect to anthocyanin content. We also tested the effect of mismatches and excess G:U base pairs on knockdown efficiency. Conclusions RNAhybrid-assisted design of smiRNAs and generation of pri-smiRNAs using a novel vector containing restriction sites greatly improves specificity and speed of the generation of stable knockdown lines for functional analyses in plants.

  20. Thermochemical cycles for the heat and cold long-range transport. Final report of the PRI 9.2 Cold transport. Annual report of the PR 2-8; Cycles thermochimiques pour le transport de chaleur et de froid a longue distance. Rapport final du PRI 9.2. Transport de froid. Rapport annuel du PR 2-8

    Luo, L.; Tondeur, D. [Laboratoire des Sciences du Genie Chimique (LSGC), 54 - Nancy (France); Mazet, N.; Neveu, P.; Stitou, D.; Spinner, B. [Institut de Science et de Genie des Materiaux et Procedes (IMP), 66 - Perpignan (France)

    2004-07-01

    This PRI deals with the use of thermochemical processes, based on solid-gas reversible transformation, to transfer heat of cold at long-range distance (> 10 km), in order to enhance the energy efficiency. Four main aspects have been studied to confirm the process feasibility: the process identification and the operating conditions, the selection of compatible reagents, the design of an auto-thermal reactor and the gas transport impact on the global performances. (A.L.B.)

  1. Multilevel hierarchy of phase separation processes in La5/8-yPryCa3/8MnO3

    García-Muñoz, J. L.; Collado, A.; Aranda, M. A. G.; Ritter, C.

    2011-07-01

    We investigate two successive hierarchized phase segregations in La5/8-yPryCa3/8MnO3, which generate ferromagnetic metallic volumes (V1FM and V2FM) having different physical origins, stabilities, and parent electronic phases. The singular percolative transition around TC2 ≈ 100 K is due to a second electronic phase separation (PS), which is specific to the charge-order insulating regions segregated at the first PS process. These findings shed new light on the metastability, atypical dynamics, the nonvolatile magnetoresistance, or the supercooling glass transition in this complex magnetic system.

  2. UČINAK KALIJEVOG I NATRIJEVOG LAKTATA NA ODRŽIVOST JUNEĆEG MLJEVENOG MESA PRI RAZLIČITIM UVJETIMA SKLADIŠTENJA

    Šmidt, Gordana; Kovačić, Mirela; Grgurić, Ivana; Bertinovec, Ines

    2009-01-01

    Svježe mljeveno juneće meso tretirano kalijevim laktatom (KL) i natrijevim laktatom (NaL) u količini od 4% dodanima pojedinačno, odnosno svaki po 2% kada su kombinirani, upakirano je u modificiranu atmosferu sačinjenu od O2 i CO2 u omjeru 80%:20%, i skladišteno pri 2ºC i 8ºC kroz 7 dana. Uzorci su analizirani prvi, četvrti, šesti i sedmi dan. Rezultati ispitivanja pokazali su da je utjecaj KL i NaL na broj aerobnih mezofilnih bakterija podjednak, te su tretirani uzorci...

  3. Combined analysis of pri-miR-34b/c rs4938723 and TP53 Arg72Pro with cervical cancer risk.

    Yuan, Fang; Sun, Ruifen; Chen, Peng; Liang, Yundan; Ni, Shanshan; Quan, Yi; Huang, Juan; Zhang, Lin; Gao, Linbo

    2016-05-01

    miR-34 family members can form a p53-miR-34 positive feedback loop and induce apoptosis, DNA repair, angiogenesis, and cell cycle arrest. We conducted a case-control study to examine whether two polymorphisms (i.e., rs4938723 in the promoter of pri-miR-34b/c and TP53 Arg72Pro) were linked to the carcinogenesis of cervical cancer among Chinese Han women. Genotypes of the two polymorphisms in 328 cervical cancer patients and 568 control subjects were determined by using a polymerase chain reaction-restriction fragment length polymorphism assay. We found a significantly increased cervical cancer risk in the pri-miR-34b/c rs4938723 under dominant and overdominant model (CT/CC vs. TT: adjusted OR = 1.34, 95 % CI = 1.01-1.77; CT vs. TT/CC: adjusted OR = 1.37, 95 % CI = 1.05-1.80, respectively). Increased cervical cancer risks were also found in the TP53 Arg72Pro under a heterozygous comparison and overdominant model (CG vs. GG: adjusted OR = 1.44, 95 % CI = 1.06-1.95; CG vs. GG/CC: adjusted OR = 1.47, 95 % CI = 1.12-1.94, respectively). Stratification analysis showed that patients carrying the pri-miR-34b/c rs4938723 CT genotype had a significantly increased risk for developing poorly differential status and clinical stage I. Moreover, increased cancer risks were observed for the TP53 Arg72Pro polymorphism in patients with poorly differential status, clinical stage II, and without lymph node metastasis. Combined analysis revealed that the genotypes of rs4938723 CT/CC and TP53 Arg72Pro CG/CC had an increased cervical cancer risk (OR = 2.21, 95 % CI = 1.38-3.53). These findings suggest that the pri-miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms may contribute to the genesis of cervical cancer.

  4. Quantitative analysis of histidine decarboxylase gene (hdcA) transcription and histamine production by Streptococcus thermophilus PRI60 under conditions relevant to cheese making.

    Rossi, Franca; Gardini, Fausto; Rizzotti, Lucia; La Gioia, Federica; Tabanelli, Giulia; Torriani, Sandra

    2011-04-01

    This study evaluated the influence of parameters relevant for cheese making on histamine formation by Streptococcus thermophilus. Strains possessing a histidine decarboxylase (hdcA) gene represented 6% of the dairy isolates screened. The most histaminogenic, S. thermophilus PRI60, exhibited in skim milk a high basal level of expression of hdcA, upregulation in the presence of free histidine and salt, and repression after thermization. HdcA activity persisted in cell extracts, indicating that histamine might accumulate after cell lysis in cheese.

  5. Quantitative Analysis of Histidine Decarboxylase Gene (hdcA) Transcription and Histamine Production by Streptococcus thermophilus PRI60 under Conditions Relevant to Cheese Making▿†

    Rossi, Franca; Gardini, Fausto; Rizzotti, Lucia; La Gioia, Federica; Tabanelli, Giulia; Torriani, Sandra

    2011-01-01

    This study evaluated the influence of parameters relevant for cheese making on histamine formation by Streptococcus thermophilus. Strains possessing a histidine decarboxylase (hdcA) gene represented 6% of the dairy isolates screened. The most histaminogenic, S. thermophilus PRI60, exhibited in skim milk a high basal level of expression of hdcA, upregulation in the presence of free histidine and salt, and repression after thermization. HdcA activity persisted in cell extracts, indicating that histamine might accumulate after cell lysis in cheese. PMID:21378060

  6. The genetic association between pri-miR-34b/c polymorphism (rs4938723 T > C) and susceptibility to cancers: evidence from published studies.

    Li, Xiaowei; Wang, Liguang; Yu, Jianyu; Xu, Jun; Du, Jiajun

    2014-12-01

    Recently, several molecular epidemiological studies have focused on the association between pri-miR-34b/c rs4938723 SNP and the susceptibility to different cancers. Due to the controversial rather than conclusive results, we performed this meta-analysis to assess more precise and comprehensive conclusion about the association. Data published until July 2014 were collected from PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure, Wanfang Data, Chinese BioMedical Literature Database, and VIP database of Chinese Journal. Ultimately, 13 articles with a total of 7,753 cases and 8,014 controls were considered eligible for inclusion. The odds ratio (OR) and its 95 % confidence interval (95%CI) were used to assess the strength of association. In the overall analysis, a significant association between pri-miR-34b/c rs4938723 polymorphism and increased cancer susceptibility was found in heterozygous model (TC vs. TT: OR = 1.148, 95%CI 1.034-1.275, P = 0.010) and dominant model (CC + TC vs. TT: OR =1.166, 95%CI 1.028-1.322, P = 0.017). In subgroup analysis of ethnicity, pri-miR-34b/c rs4938723 polymorphism was significantly associated with an increased cancer susceptibility for Asian population in heterozygous model (TC vs. TT: OR = 1.169, 95%CI 1.031-1.326, P = 0.015) and dominant model (CC + TC vs. TT: OR = 1.185, 95%CI 1.017-1.382, P = 0.030), whereas no significant association for Caucasian population was observed in any genetic models. Intriguingly, stratified analysis revealed opposite results that pri-miR-34b/c polymorphism contributed to susceptibility to hepatocellular carcinoma while reduced susceptibility to colorectal cancer and esophageal squamous cell cancer in Asians. Considering some limitation of our meta-analysis, future well-designed case-control studies with larger sample sizes are required to confirm our findings.

  7. Deinterleaving of Radar Signals Based on Modified PRI Transform Algorithm%一种改进型PRI变换雷达信号分选技术

    赵永胜

    2007-01-01

    在对传统的脉冲重复间隔(PRI)变换法进行介绍的基础上,提出了一种改进型的PRI变换法来估计脉冲重复间隔,并给出了相应的门限设定方法,另外,文中还提出了一种适用的快速脉冲抽取算法.仿真表明,该方法对固定PRI、抖动PRI和参差PRI脉冲序列都有较好的估计效果.

  8. Optimizacija svojstava samoorganiziranja graft kopolimera metoksi poli(etilen glikola) i masnih kiselina pri pripravi nanonosača s uklopljenim etopozidom

    Varshosaz, Jaleh; HASANZADEH, FARSHID; ESLAMDOOST, MOJTABA

    2012-01-01

    Cilj je rada bio ispitati svojstva samoorganiziranja micela pripravljenih od graft kopolimera metoksipolietilenglikola (mPEG) i masnih kiselina različite duljine lanca za uklapanje etopozida. Sintetizirana su tri amfifilna kopolimera povezivanjem miristinske, stearinske i behenične kiseline esterskom vezom s mPEG. Veličina i zeta-potencijal micela određeni su metodom dinamičkog raspršivanja svjetlosti. Micele s uklopljenim etopozidom pripravljene su film-metodom pri različitim omjerima lijeka...

  9. Conductivity of single-crystal Y1-yPryBa2Cu3O7-δ over a wide range of temperatures and Pr concentrations

    Khadzhai, G. Ya.; Vovk, N. R.; Vovk, R. V.

    2014-06-01

    The in-plane electrical resistance of Y1-yPryBa2Cu3O7-δ single crystals with a high degree of perfection is studied for temperatures in the range TC-300 K, where TC ranges from 92 to 52 K, with varying praseodymium content. The experimental data are approximated by an expression that takes electron scattering on phonons and defects into account, as well as fluctuation conductivity in a 3D Aslamazov-Larkin model. According to the approximation data the Debye temperature ranges from 350-370 K, depending on the praseodymium content. The transverse coherence length is ˜1 Å.

  10. La democracia interna en los partidos políticos: el caso del PRI de México entre 1965-1984

    Contreras Romero, Valente Alberto

    2015-01-01

    El presente trabajo de investigación pretende analizar los procesos de selección interna de candidatos a puestos de elección popular dentro de los partidos políticos especialmente aquellos donde se apliquen métodos de selección incluyentes y democraticos. El trabajo se enfocara principalmente en los partidos políticos hegemónicos en regímenes poco democraticos como fue el caso de México, para este efecto se realizará un estudio de caso aplicado al Partido Revolucionario Institucional (PRI) ...

  11. Congés… pour « prières » Prayers and days off

    Claudine Viard

    2009-04-01

    Full Text Available Les premiers combats de la classe ouvrière se sont portés sur la demande d’une journée de repos, qui par tradition chrétienne a été fixée le dimanche en 1906. Quatre journées de congé à caractère chrétien ont en outre été retenues par le législateur. L’exercice du culte est donc concrètement garanti pour les chrétiens. Avec l’arrivée sur le territoire de la République  de populations de confessions variées, cette organisation du travail apparaît inégalitaire, voire de nature à porter atteinte à la liberté religieuse. Il a été proposé de reconnaître les jours de prières d’autres confessions. Pour l’instant, le législateur n’a pas adopté ces propositions. Mais la question reste posée. Or, la jurisprudence des tribunaux judiciaires et administratifs admet le droit de prier des fidèles des cultes minoritaires, ils peuvent prétendre à un congé lors des fêtes de leur religion dans la mesure où cela n’occasionne pas de perturbation. La consécration de cette jurisprudence souple par le législateur serait de nature à calmer le débat.At the turn of the century, the working classes fought for a day off in the week, which was granted on Sundays by the legislator in 1906. Four additional christian holidays are also legal. So the right to pray is garanteed for christians. As different populations with various faiths settled in France, this organisation has seemed to violate the principle of equality, and religious freedom. There has been a debate on the question whether some of the days of minority religions should also be observed by all the population. But so far, the legislator has not voted any of these proposals. It remains an issue. The French judge has consistently decided that the people of non christian faiths had the right to be granted a day off to pray on these special days, provided it would not cause prejudice to the organisation they work for. It might help to calm the debate if this

  12. Pri-miR-34b/c rs4938723 polymorphism is associated with a decreased risk of gastric cancer.

    Pan, Xin-Min; Sun, Rui-Fen; Li, Zhao-Hui; Guo, Xiao-Min; Qin, Hao-Jie; Gao, Lin-Bo

    2015-04-01

    Previous studies have demonstrated that miR-34 family members are abnormally expressed in gastric cancer. Overexpression of the miR-34 family suppresses gastric carcinogenesis, whereas downregulation of the miR-34 family promotes tumorigenesis. p53 can bind to the promoter region of miR-34b/c, leading to an increase of miR-34b/c expression. Recently, a variant in the promoter region of pri-miR-34b/c (rs4938723) has been discovered, with the function of altering the binding efficiency of transcription factor GATA. The purpose of this study was to examine the role of the miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms in the susceptibility of gastric cancer. We analyzed the distribution of the two polymorphisms in 197 patients with gastric cancer and 289 age-, gender-, ethnicity-, and living area-matched controls using polymerase chain reaction-restriction fragment length polymorphism and DNA direct sequencing. We found that the CT and CT/CC genotypes of the miR-34b/c rs4938723 were associated with a significantly decreased risk of gastric cancer compared with the TT genotype (CT vs. TT: odds ratio [OR]=0.66; 95% confidence interval [95% CI], 0.45-0.97; and CT/CC vs. TT: OR=0.67; 95% CI, 0.47-0.97, respectively). Combined analysis showed that subjects carrying the miR-34b/c rs4938723 CT/CC and TP53 CG/CC genotypes had a 0.62-fold decreased risk to develop gastric cancer compared with subjects carrying the miR-34b/c rs4938723 TT and TP53 CG/CC genotypes (OR=0.62; 95% CI, 0.40-0.96). These findings suggest that the miR-34b/c rs4938723 may individually and jointly have a protective effect on the risk of gastric risk.

  13. PAZ, PRI, AND PROGRESS: OCTAVIO PAZ’S POLITICAL, ECONOMIC AND LITERARY STRUGGLE TO INSPIRE REFORM IN TWENTIETH-CENTURY MEXICO

    D. Gene Pace

    2003-01-01

    Full Text Available Throughout most of the twentieth century; Mexico’s political and economic policies were heavily influenced by the Partido Revolucionario Institutional (PRI. The landmark 1998 victory by Vicente Fox, the first presidential candidate in seven decades to win without the official sanction of the PRI,marked an important milestone in Mexican history; Octavio Paz, an eloquent proponent of political, economic, and social reform, sought for decades to inspire change. This paper seeks to illuminate Paz’s economic philosophy, and to demonstrate how the acclaimed writer, through courageous symbolic action coupled with an inimitable and potent pen, challenged the PRI’s hegemony in Mexico and contributed to the historic election he almost lived to celebrate (an elderly Paz died shortly before the historic 1998 election.“The Aztec ritual of 2 October [1968] in the Plaza de Tlatelolco. . . convinced me to abandon the Mexican Foreign Service.”“October 2, 1968 ended the student movement. It also ended an era in thehistory of Mexico.”

  14. PRI变换在脉冲列去交错中的适用性分析%Applicability Analysis of PRI Transform in Pulse Train Destagger

    安振; 李运祯

    2007-01-01

    传统雷达脉冲列去交错方法中的脉冲重复间隔(PRI)估计算法,是以接收到的脉冲串的自相关函数为基础,很容易出现信号的PRI及其整数倍(即子谐波)同时存在的现象,给雷达脉冲串的去交错造成了困难.为克服上述缺点,提出了PRI变换的估计方法,几乎完全抑制了出现在自相关函数中的子谐波.研究了这种算法对于各种不同PRI信号的适用性.计算机仿真结果表明,这种算法适用于检测不同信号的PRI.

  15. Nova libro pri interlingvistiko

    2006-01-01

    Rets rmt.: Blanke, Detlev. Interlinguistische Beiträge : zum Wesen und zur Plansprachen / herausgegeben von Sabine Fiedler. Frankfurt/Main, Berlin ; Bern ; Bruxelles ; New York ; Oxford ; Wien : Europäischer Verlag der Wissenschaften Peter Lang

  16. Patología del sueño en las enfermedades priónicas Sleep disorders in prion diseases

    T. Ayuso

    2007-01-01

    Full Text Available Las enfermedades priónicas son un grupo de encefalopatías con cambios neurodegenerativos causados por una proteína alterada denominada prión cuyo dato característico es la transmisibilidad. Ocurren la mayoría de las veces de forma esporádica aunque un grupo de ellas son familiares asociadas a mutaciones en el gen de la proteína priónica. El polimorfismo genético parece determinar las diferentes variantes familiares. Una de las más enigmáticas e inhabituales es el Insomnio Letal Familiar (ILF, trastorno hereditario caracterizado por pérdida del sueño fisiológico con estupor onírico, hiperactividad autonómica y motora, y anomalías motoras. La polisomnografía de esta entidad refleja la incapacidad para producir un patrón fisiológico del sueño NREM y REM, así como de las fluctuaciones circadianas hormonales y vegetativas; la transición de vigilia a sueño está marcadamente alterada con desaparición precoz de los husos de sueño. La hipótesis del origen de estos trastornos es la pérdida neuronal talámica, especialmente en los núcleos anterior y dorsomedial, descrita en la neuropatología de estos pacientes; además la PET revela hipofunción de núcleos talámicos, centros responsables del control vigilia-sueño. En la enfermedad de Creutzfeldt-Jakob las alteraciones de sueño-vigilia no se han considerado características, no obstante, se han encontrado frecuentes alteraciones en los registros electroencefalográficos de sueño. Además de la neurodegeneración talámica puede haber mecanismos etiopatogénicos comunes en las enfermedades priónicas en relación con la función biológica de la proteína priónica.Prion diseases are a group of encephalopathies with neurodegenerative changes caused by an altered protein named prion whose characteristic datum is transmissibility. In most cases they occur in a sporadic form although a group of them are familial associated with mutations in the gene of the prion protein

  17. 一种基于PRI谱特征的复杂雷达信号分选方法%A method of complex radar signal sorting based on PRI spectrum signatures

    王亚莉; 胡进

    2011-01-01

    通过分析雷达截获机所处的复杂雷达信号环境,提出了一种基于PR I谱特征的复杂雷达信号分选方法。该方法利用PR I变换获取雷达信号PR I谱,并根据各种复杂雷达信号PR I谱特征实现复杂雷达信号的分选工作。仿真结果表明,该方法能够较好地实现复杂信号环境下雷达信号的分选工作。%In view of the complex radar signal environment for radar interceptors,a method of the complex radar signal sorting based on the PRI spectrum signatures is presented.The PRI spectrum is obtained through the PRI transform,and the complex radar signal sorting is realized based on the PRI spectrum signatures of various complex radar signals.The simulation results show that the method can better realize radar signal sorting in the complex signal environment.

  18. Base-pair opening dynamics of the microRNA precursor pri-miR156a affect temperature-responsive flowering in Arabidopsis.

    Kim, Hee-Eun; Kim, Wanhui; Lee, Ae-Ree; Jin, Suhyun; Jun, A Rim; Kim, Nak-Kyoon; Lee, Joon-Hwa; Ahn, Ji Hoon

    2017-03-18

    Internal and environmental cues, including ambient temperature changes, regulate the timing of flowering in plants. Arabidopsis miR156 represses flowering and plays an important role in the regulation of temperature-responsive flowering. However, the molecular basis of miR156 processing at lower temperatures remains largely unknown. Here, we performed nuclear magnetic resonance studies to investigate the base-pair opening dynamics of model RNAs at 16 °C and investigated the in vivo effects of the mutant RNAs on temperature-responsive flowering. The A9C and A10CG mutations in the B5 bulge of the lower stem of pri-miR156a stabilized the C15∙G98 and U16∙A97 base-pairs at the cleavage site of pri-miR156a at 16 °C. Consistent with this, production of mature miR156 was severely affected in plants overexpressing the A9C and A10CG constructs and these plants exhibited almost no delay in flowering at 16 °C. The A10G and A9AC mutations did not strongly affect C15∙G98 and U16∙A97 base-pairs at 16 °C, and plants overexpressing A10G and A9AC mutants of miR156 produced more mature miR156 than plants overexpressing the A9C and A10CG mutants and showed a strong delay in flowering at 16 °C. Interestingly, the A9AC mutation had distinct effects on the opening dynamics of the C15∙G98 and U16∙A97 base-pairs between 16 °C and 23 °C, and plants expressing the A9AC mutant miR156 showed only a moderate delay in flowering at 16 °C. Based on these results, we propose that fine-tuning of the base-pair stability at the cleavage site is essential for efficient processing of pri-miR156a at a low temperature and for reduced flowering sensitivity to ambient temperature changes.

  19. Sun-induced Chlorophyll fluorescence and PRI improve remote sensing GPP estimates under varying nutrient availability in a typical Mediterranean savanna ecosystem

    Perez-Priego, O.; Guan, J.; Rossini, M.; Fava, F.; Wutzler, T.; Moreno, G.; Carvalhais, N.; Carrara, A.; Kolle, O.; Julitta, T.; Schrumpf, M.; Reichstein, M.; Migliavacca, M.

    2015-07-01

    This study investigates the performances of different optical indices to estimate gross primary production (GPP) of herbaceous stratum in a Mediterranean savanna with different Nitrogen (N) and Phosphorous (P) availability. Sun-induced chlorophyll Fluorescence yield computed at 760 nm (Fy760), scaled-photochemical reflectance index (sPRI), MERIS terrestrial-chlorophyll index (MTCI) and Normalized difference vegetation index (NDVI) were computed from near-surface field spectroscopy measurements collected using high spectral resolution spectrometers covering the visible near-infrared regions. GPP was measured using canopy-chambers on the same locations sampled by the spectrometers. We hypothesized that light-use efficiency (LUE) models driven by remote sensing quantities (RSM) can better track changes in GPP caused by nutrient supplies compared to those driven exclusively by meteorological data (MM). Particularly, we compared the performances of different RSM formulations - relying on the use of Fy760 or sPRI as proxy for LUE and NDVI or MTCI as fraction of absorbed photosynthetically active radiation (fAPAR) - with those of classical MM. Results showed significantly higher GPP in the N fertilized experimental plots during the growing period. These differences in GPP disappeared in the drying period when senescence effects masked out potential differences due to plant N content. Consequently, although MTCI was tightly related to plant N content (r2 = 0.86, p < 0.01), it was poorly related to GPP (r2 = 0.45, p < 0.05). On the contrary sPRI and Fy760 correlated well with GPP during the whole measurement period. Results revealed that the relationship between GPP and Fy760 is not unique across treatments but it is affected by N availability. Results from a cross validation analysis showed that MM (AICcv = 127, MEcv = 0.879) outperformed RSM (AICcv = 140, MEcv = 0.8737) when soil moisture was used to constrain the seasonal dynamic of LUE. However, residual analyses

  20. A Recognition Algorithm for Radar PRI Modulation Mode Based on Extremum Sequence Features Set%基于极值序列特征集的雷达PRI调制模式识别算法

    周一鹏; 王星; 田元荣; 周东青; 程嗣怡

    2016-01-01

    识别雷达信号的脉冲重复间隔( PRI)调制模式是分析雷达工作状态和工作任务的重要手段。针对复杂体制雷达的PRI调制模式可实时切换并改变调制参数因而难于识别的问题,提出一种基于极值序列特征集的雷达PRI调制模式识别算法。该算法首先提取PRI序列的极值特征,构建极值序列特征集;然后,基于PRI序列及其特征集建立恒参、类正弦、正弦和抖动判定准则,实现雷达PRI调制模式的分层识别。仿真分析表明:该算法对复杂体制雷达PRI调制模式的识别正确率达95.3%,同时具有较高的实时性,在电子对抗应用领域具有良好的前景。%The recognition of pulse repetition interval ( PRI) modulation mode is meaningful for analyzing the condition and task of radar.In order to recognize advanced radar which could change its PRI modulation mode and parameters quickly , a recognition al-gorithm based on extremum sequence features set is proposed .Firstly, by extracting the extremum sequence features from PRI se-quence , the PRI extremum features set is constructed .Then the judge criterions of five PRI modulation modes based on PRI se-quence and its extremum features set is proposed .Finally, a multi-layer recognition algorithm is presented .The result shows that the recognition algorithm has preferable recognition correct rate (95.3%), and could classify the PRI modulation modes quickly , so the resae rch has a good application prospect in electronic support measures.

  1. 一种抗 SDIF 分选的脉冲重复间隔参差设计方法%A Design Method of PRI Stagger Countering the SDIF Sorting Algorithm

    张保群

    2016-01-01

    To improve the anti-sorting and anti-recognition ability of radars against electronic reconnaissance systems,a design method of PRI stagger for radar signals was proposed based on the idea of destroying the performance of sorting with the pulse repetition interval (PRI).The working process of a typical PRI sorting algorithm,the sequential difference histogram (SDIF)was analyzed,and some critical steps were discussed.It is revealed that,when the staggered PRI values are chosen properly under some contracts,the correct sorting processing can be destroyed,as a result,more than one targets appear in the sorting results.Simulation results show that,the presented design is effective during countering the signal sorting based on the SDIF,therefore it provides a preliminary theoretical guidance for the radio frequency stealth design of radar signals.%为提高雷达对电子侦察系统抗分选识别能力,从破坏脉冲重复间隔(PRI)分选性能的角度出发,提出了一种雷达信号 PRI 参差设计方法。根据典型的序列差值直方图(SDIF)算法的工作流程,分析了 SDIF 实现 PRI 参差信号分选的关键步骤。合理设计参差 PRI 取值,使其满足一定约束条件,可以破坏正确分选流程,达到分选结果中目标增批的目的。仿真结果表明,该设计方法能有效对抗基于 SDIF 的信号分选策略,可以为雷达信号射频隐身设计提供初步的理论指导。

  2. PRI 2.1: Basic researches on the photovoltaic: new materials (july 2002 - july 2004). Final report of the integrated research project; PRI 2.1: Recherches de base en photovoltaique: nouveaux materiaux (Juillet 2002 - Juin 2004). Rapport final du projet de recherche integre

    Marfaing, Y.

    2004-07-01

    The main material of the photovoltaic cells is the massive crystalline silicon. For a large scale development of the photovoltaic industry, it is necessary to use thin layers. Many materials are possible to reach this objective: different types of silicon (amorphous, mono-crystal, poly-crystal), poly-crystal of CIS type (CuInSe{sub 2}) and organic molecules and polymers. The last two types are innovative and need some researches. These research axis are presented in this PRI. (A.L.B.)

  3. PRI Detection of Segment Pulse Trains Based on Transform Spectrum Coherent Accumulation%基于变换谱相干积累的片段信号PRI检测

    张什永; 胡泽宾; 王俊文

    2012-01-01

    Due to the effects of search modes and targets' beam scheduling, the reconnaissance systems can only intercept segment pulse trains from emitters, which is a big challenge for signal sorting. For this problem, a new method based on PRI transform spectrum coherent accumulation is proposed. PRI transform algorithm is introduced. The relationship between PRI spectrum peak value and pulse number included is given and its coherent accumulation feature is then revealed. Simulation results show that the new method can efficiently enhance PRI spectrum and is favourable to improve the detection propability.%受自身搜索方式和目标辐射源波束调度的影响,侦察系统往往只能截获辐射源的部分信号,这为后续分选处理带来了很大挑战.针对该问题,提出了通过时PRI变换谱进行相干积累以提高真实PRI检测概率的方法.首先介绍了PRI变换法,对算法原理进行了说明;接着从理论上推导了PRI变换谱峰值与脉冲个数的关系,指出了PRI变换谱的相干积累特性,并分析了其对虚假脉冲的适应能力;最后通过仿真试验对理论分析进行了验证.仿真结果表明,文中提出的方法能够有效提高片段信号的PRI 谱峰,从而有利于提高检测概率.

  4. An accurate estimation algorithm for PRI based on remainder of the cycle%一种基于余数周期的 PRI精确估计算法

    苏焕程; 张君; 程良平; 程亦涵; 冷魁

    2016-01-01

    针对传统脉冲重复间隔(PRI)分选算法在估计PRI方面存在的不足,提出了一种对PRI周期信号的周期进行精确估计的算法。该算法首先从待分选脉冲序列中提取出属于一部雷达的脉冲样本,然后利用同余方程的余数周期性质对该雷达脉冲序列的PRI进行精确的估计。相对于传统的PRI估计算法,该算法有效地消除了TOA量化误差对PRI估计造成的影响,可以精确地估计出雷达脉冲序列的准确 PRI数值,从而能够更好地满足信号分选算法的处理需求。理论推导及仿真实验均表明了该算法的有效性。%For the defects in estimating pulse repetition interval (PRI) of traditional PRI de‐interleaving al‐gorithms ,a new algorithm of estimating the period of PRI periodic signals is put forward .The algorithm firstly extracts the pulse sample sequence of certain radar from the raw pulse sequence ,and then executes precise period estimation process based on the remainder of the cycle .Compared with the traditional PRI estimating algorithms ,this algorithm accurately estimates the PRI with TOA quantization error removing , which satisfies the requirement of the de‐interleaving process . Both theoretical derivation and simulation results verify the validity of the proposed algorithm .

  5. Izobraževalna debata kot metoda makro-didaktične komponente preverjanje z ocenjevanjem pri pouku KEMIJE in NARAVOSLOVJA v osnovni šoli

    Horvat, Davorin

    2014-01-01

    Hiter napredek znanosti in informacijske tehnologije ter dostopnosti do informacij preko medmrežja silijo k drugačnemu, alternativnemu načinu poučevanja (Pisar, 2006). Učence je potrebno uvajati v interdisciplinarno povezovanje aktualnih predmetnih področij. Aktivno učenje s pomočjo različnih metod dela ima pri vzgojno–izobraževalnem procesu čedalje večji pomen. Z metodo izobraževalne debate pridobijo učenci nekatere veščine, potrebne za uspešno soočanje z izzivi današnjega časa. Ta metod...

  6. Extracción de una Proteasa Anti-Priónica de Líquenes (Orden: LECANORALES) en Fluido Gástrico e Intestinal Artificial -resumen-

    Ricardo Millán-González; J Ducett; Johnson, C.

    2014-01-01

    La proteína priónica anormal (PrPTSE) es el agente etiológico de las encefalopatías espongiformes trasmisibles. Esta proteína posee una alta resistencia a ser inactivada por agentes químicos y ambientales‚ como la radiación y el calor‚ lo cual le da la capacidad de persistir en la tierra durante un periodo mayor a tres años después de haber sido enterrado‚ generando así una reserva de infectividad. Los líquenes son organismos simbióticos conformados por un hongo y un agente fotosintético que ...

  7. La proteína priónica celular: Análisis de su función neuroprotectora y reguladora del ciclo Celular

    Carulla Martí, Patricia

    2013-01-01

    [spa] Las encefalopatías espongiformes transmisibles (EETs) son un conjunto de enfermedades neurodegenerativas letales que afectan tanto animales como humanos. Están causadas por unas partículas proteicas denominadas “priones”, resultantes de la transformación de la proteína priónica celular (PrP(C)) a una forma patogénica denominada PrP(SC), que se acumula en el cerebro en forma de agregados e induce la transformación de más moléculas a expensas de la reducción de los niveles de PrP(C)...

  8. Lower Oligocene non-geniculate coralline red algal (Corallinales, Rhodophyta assemblage from Poljšica pri Podnartu (Upper Carniola, Slovenia

    Luka Gale

    2008-12-01

    Full Text Available The Lower Oligocene Gornji Grad beds from Polj{ica pri Podnartu consist of marly limestone, mudstone, several layers of limestones and two layers of sandstones, and were deposited on a mixed carbonate-siliciclastic ramp.Especially the limestones contain rich fossil fauna and non-geniculate coralline red algae. These were systematicallycollected from four horizons and researched in thin sections under an optical microscope. Genera Lithoporella,Neogoniolithon, Spongites, Lithothamnion, Mesophyllum and Spongites were recognized. Surface area for each genus was calculated and the differences in the coralline assemblages in the four horizons were analysed. Thecorallines originate from two source areas: sandy-muddy bottom of a shallow marine environment, and small coral bioherms with its encrusters.

  9. Fazna ravnoteža u sustavu NaNO3/KNO3 + glicerol + voda pri 288.15 K i 298.15 K

    Zhang, H.-Y.; Zhu, W.-W.; Qin, G.-L.; Wei, Z.

    2014-01-01

    U ternarnom sustav NaNO3/KNO3 + glicerol + voda određeni su topljivost, gustoća i indeks loma pri 288,15 K i 298,15 K. Topljivost je izračunata na temelju gustoće i indeksa loma. U svim se slučajevima topljivost smanjuje s povećanjem udjela glicerola. Za indeks loma uočen je suprotan trend. Dodatkom glicerola smanjuje se gustoća otopine NaNO3, a povećava gustoća otopine KNO3. Eksperimentalni podatci za zasićene i podzasićene otopine korelirani su empirijskom jednadžbom s četiri i sedam parame...

  10. 基于PRI的雷达脉冲序列分选方法%Algorithms for Sorting of Radar Pulses Based on PRI

    杨文华; 高梅国

    2005-01-01

    高密度复杂信号环境下的信号分选处理技术是新一代雷达截获接收机信号处理的关键技术,也是雷达截获领域一个亟待解决的问题.文中讨论基于脉冲重复间隔(PRI)的脉冲分选算法,深入分析了基于直方图统计算法和PRI变换算法的优缺点,并对算法进行计算机仿真.最后针对这两种算法的优缺点提出一种综合的分选算法.

  11. 基于PRI变换和小波变换的雷达信号分选%Sorting of Radar Signal Based on PRI transfer and wavelet transfer

    韩俊; 何明浩; 翟卫俊; 陈昌孝

    2007-01-01

    分析了脉冲重复间隔(PRI)变换算法和小波变换算法的基本原理,针对两种算法在雷达信号分选中的优缺点,提出了一种基于PRI变换和小波变换相结合的雷达信号综合分选方法.该方法首先利用PRI变换对雷达信号粗分选,然后应用小波变换进行细分选.仿真结果表明,在信噪比不低于10dB的条件下,该方法准确可行.

  12. Odpadna embalaža in problem pri odpadni embalaži s pretisnimi omoti v farmacevtskem podjetju Krka d.d.

    Krajnc, Urška

    2015-01-01

    Diplomska naloga obsega problem, ki nastane zaradi čedalje večjega in obsežnejšega nastajanja odpadne embalaže, in konkreten problem, s katerim se srečujejo v farmacevtskem podjetju Krka, d. d., iz Novega mesta. Kot nam je znano, je z odpadki vse več težav. S prostorskega vidika je to kopičenje odpadkov, z okoljskega vidika pa onesnaževanje okolja. Embalaža, ki predstavlja odpadek, ki ga ne potrebujemo več, nam predstavlja predmet, ki ga odvržemo. Pri tem je smiselno premisliti, če je embalaž...

  13. A SNP site in pri-miR-124 changes mature miR-124 expression but no contribution to Alzheimer's disease in a Mongolian population.

    Qi, Lu; Hu, Yi; Zhan, Ying; Wang, Jing; Wang, Bing-Bing; Xia, Hong-Fei; Ma, Xu

    2012-04-25

    Increasing evidence shows that single nucleotide polymorphisms (SNPs) or mutations in microRNAs (miRNAs) sequence may affect the processing and function of miRNAs and participate in the occurrence of diseases. Although many SNPs of miRNAs were found, their functions in the pathological process of nerve cells were only just emerging. In the present study, the effect of the SNP of one neuronal miRNA, miR-124, on miRNA biogenesis and human genetic disease was investigated using in vitro cell line model and Alzheimer's disease (AD) in the Mongolian population. Bioinformatics prediction showed that a common G/C polymorphism designated rs531564 was found in the pri-miR-124 and the G allele changed the formation of a ring-shaped structure in the predicted secondary structure of the pri-miRNA for miR-124-1. Northern blot and real-time PCR analysis showed that the amount of mature miR-124 from the C/G heterozygosity of rs531564 was increased compared with the CC or GG homozygosity of rs531564. The expression of mature miR-124 from GG homozygosity was also higher than that from CC homozygosity. But in an association study of AD patients and controls, neither genotype nor allele distribution difference was found in AD patients compared with controls. Collectively, the present study is the first to evaluate the relationship between miR-124 and AD in the Mongolian population. SNP rs531564 of miR-124 may not represent a risk factor in the development of AD among Mongolian population.

  14. A novel marsupial pri-miRNA transcript has a putative role in gamete maintenance and defines a vertebrate miRNA cluster paralogous to the miR-15a/miR-16-1 cluster.

    Au, Phil Chi Khang; Frankenberg, Stephen; Selwood, Lynne; Familari, Mary

    2011-10-01

    Successful maintenance, survival and maturation of gametes rely on bidirectional communication between the gamete and its supporting cells. Before puberty, factors from the gamete and its supporting cells are necessary for spermatogonial stem cell and primordial follicle oocyte maintenance. Following gametogenesis, gametes rely on factors and nutrients secreted by cells of the reproductive tracts, the epididymis and/or oviduct, to complete maturation. Despite extensive studies on female and male reproduction, many of the molecular mechanisms of germ cell maintenance remain relatively unknown, particularly in marsupial species. We present the first study and characterisation of a novel primary miRNA transcript, pri-miR-16c, in the marsupial, the stripe-faced dunnart. Bioinformatic analysis showed that its predicted processed miRNA - miR-16c - is present in a wide range of vertebrates, but not eutherians. In situ hybridisation revealed dunnart pri-miR-16c expression in day 4 (primordial germ cells) and day 7 (oogonia) pouch young, in primary oocytes and follicle cells of primordial follicles but then only in follicle cells of primary, secondary and antral follicles in adult ovaries. In the adult testis, pri-miR-16c transcripts were present in the cytoplasm of spermatogonial cells. The oviduct and the epididymis both showed expression, but not any other somatic tissues examined or conceptuses during early embryonic development. This pattern of expression suggests that pri-miR-16c function may be associated with gamete maintenance, possibly through mechanisms involving RNA transfer, until the zygote enters the uterus at the pronuclear stage.

  15. 利用光化学反射植被指数估算光能利用率研究的进展%The Review of Estimating Light Use Efficiency through Photochemical Reflectance Index(PRI)

    陈晋; 唐艳鸿; 陈学泓; 杨伟

    2008-01-01

    植被光能利用率(LUE)是估计植被初级生产力(GPP)和净初级生产力(NPP)模型的一个重要输入,准确地估计LUE对于生态学研究有重要的意义.由于LUE随环境的变化关系十分复杂,现有的LUE估算模型过于粗糙简单,而通过遥感直接估计LUE将会更加可靠.研究表明,光化学反射植被指数(PRI)与LUE有很好的相关性,故PRI在利用遥感估计LUE方面具有极大的潜力.但是很多研究也发现了PRI-LUE的关系不够稳健,受许多因素的干扰,比如物种构成、冠层结构及大气等.因此,PRI的广泛应用还需要更多的研究.本文首先介绍了PRI的定义及PRI随LUE变化的生理机制,再综述了一些利用遥感手段建立PRI-LUE关系的例子,然后分析了影响PRI-LUE关系的各种干扰因素,最后对PRI研究取得的成果、存在的问题以及发展前景作了总结.

  16. A study on signal sorting algorithm based on PRI spectrum signatures for staggered radars%基于PRI谱内特征的参差雷达信号分选算法研究

    韩卫国; 胡进; 倪静静

    2011-01-01

    In view of the basic signatures of radar signals and some deficiencies of the PRI transform algorithm in the signal sorting,a signal sorting algorithm based on the PRI spectrum signatures for staggered radars is presented.The time-domain PRI spectrum of t%通过分析参差雷达信号的基本特征,针对PRI变换算法在参差雷达信号分选中存在的不足,提出了一种基于PRI谱内特征的参差雷达信号分选算法。该算法利用PRI变换获取信号的时域PRI谱,进而根据PRI谱内脉冲对数特征完成参差信号帧周期的分选工作。仿真结果表明,该方法能够较好地实现参差雷达信号的分选工作。

  17. Comparison of the architectural and urban design workshop: in the town of Križevci pri Ljutomeru and the Jelovica architectural workshop

    Tomaž Krušec

    2013-07-01

    Full Text Available The aim of the paper is to draw attention to the key advantages and potential disadvantages of the different types of architectural workshops and architectural/urban design workshops, i.e. based on an analysis and comparison of two workshops: architectural and urban design workshop in the town of Križevci pri Ljutomeru and the architectural workshop organised by the Jelovica Hiše d.o.o. company. The first workshop tried to find practical solutions to certain spatial problems of the town that the workshop addressed, while the client of the second workshop expected from the students to develop innovative solutions in using a specific building system for designing contemporary residential typologies. The differences in expectations meant that the workshops were carried out differently. In the first workshop, it was essential that the students stayed in the town that was the subject of the workshop, while in the second one, it was important that the students grasped the characteristics of the technological process and the special features of the building. To achieve this, the students made several visits to the company’s production plants and, as an end product of the workshop, the students had to produce a part of their designed structure. This was a most direct way of familiarising themselves with the way of building

  18. A SNP in pri-miR-10a is associated with recurrent spontaneous abortion in a Han-Chinese population.

    Li, Ying; Wang, Xue-Qin; Zhang, Lu; Lv, Xiao-Dan; Su, Xing; Tian, Shi; Liu, Chun-Mei; Ma, Xu; Xia, Hong-Fei

    2016-02-16

    MicroRNA-10a (miR-10a) has a wide range of functions in nearly all mammalian tissues and is involved in the occurrence of many diseases. However, it remains unknown whether miR-10a is associated with human recurrent spontaneous abortion (RSA). In this study, we found that rs3809783 A > T in miR-10a coding region was significantly associated with the increase of the risk of human unexplained RSA (URSA) acquisition in a Han-Chinese population. The T allele of rs3809783 hindered the production of mature miR-10a. A to T substitution in miR-10a rs3809783 repressed cell proliferation and migratory capacity. Further investigation discovered that Bcl-2-interacting mediator (Bim) was the functional target of miR-10a and inversely regulated Bim expression. Dual-luciferase assay indicated that A allele in miR-10a rs3809783 could more effectively suppress Bim expression than T allele. In addition, A to T substitution in miR-10a rs3809783 attenuated the sensibility of cells to progesterone and its antagonist mifepristone. Collectively, our data suggest that rs3809783 A > T in pri-miR-10a may be conductive to the genetic predisposition to RSA by disrupting the production of mature miR-10a and reinforcing the expression of Bim.

  19. microTSS: accurate microRNA transcription start site identification reveals a significant number of divergent pri-miRNAs.

    Georgakilas, Georgios; Vlachos, Ioannis S; Paraskevopoulou, Maria D; Yang, Peter; Zhang, Yuhong; Economides, Aris N; Hatzigeorgiou, Artemis G

    2014-12-10

    A large fraction of microRNAs (miRNAs) are derived from intergenic non-coding loci and the identification of their promoters remains 'elusive'. Here, we present microTSS, a machine-learning algorithm that provides highly accurate, single-nucleotide resolution predictions for intergenic miRNA transcription start sites (TSSs). MicroTSS integrates high-resolution RNA-sequencing data with active transcription marks derived from chromatin immunoprecipitation and DNase-sequencing to enable the characterization of tissue-specific promoters. MicroTSS is validated with a specifically designed Drosha-null/conditional-null mouse model, generated using the conditional by inversion (COIN) methodology. Analyses of global run-on sequencing data revealed numerous pri-miRNAs in human and mouse either originating from divergent transcription at promoters of active genes or partially overlapping with annotated long non-coding RNAs. MicroTSS is readily applicable to any cell or tissue samples and constitutes the missing part towards integrating the regulation of miRNA transcription into the modelling of tissue-specific regulatory networks.

  20. 基于PRI变换的雷达信号分选%De-interleaving of Radar Signals Based on PRI Transform Algorithm

    邹顺; 张群飞; 靳学明

    2006-01-01

    雷达信号分选是电子对抗的关键技术,而脉冲重复间隔是雷达信号分选的关键参数.目前基于PRI参数提出了很多分选方法.传统的PRI变换法对脉冲重复间隔具有很高的估计精度,它克服了直方图统计法中的子谐波问题,但是它的抗抖动能力很差.该文引入的修正的PRI变换法针对传统PRI变换法的缺点,利用可变的时间起点避免了相位因子的相位差,利用重叠的PRI箱增加PRI箱宽度,有效地克服了传统PRI变换中的缺点.此外,文中还给出了相应的门限设定方法和快速的脉冲抽取算法.仿真表明,该修正的PRI变换算法对固定PRI、抖动PRI和参差PRI脉冲序列都有较好的估计效果,它是精度较高的雷达信号分选方法.

  1. The exploitation of micromorphological parameters for identification in the section / Mentha Využitie mikromorfologických parametrov pri identifikácii v sekcii Mentha

    Fialová S.

    2015-06-01

    Full Text Available Identifikacia druhov v rode Mentha L. je obzvlašť naročna. Je to sposobene ľahkym križenim podporenym gynodioeciou, ktora je ďalej skomplikovana polymorfizmom, pestovanim, polyploiditou a vegetativnym rozmnožovanim, čo vysvetľuje genetickopopulačne a mikroevolučne pozadie premenlivosti v rode Mentha. V tejto praci sme študovali využitie mikromorfologickych a fytochemickych parametrov pri identifikacii a charakterizacii vybranych druhov rodu Mentha. Na spodnej pokožke listov 20 populacii Mentha sme stanovili veľkosť a počet „žliazok typu Lamiaceae“. Silicu sme analyzovali pomocou GC MS. Identifikovali a charakterizovali sme populacie druhov M. × piperita, M. spicata, M. spicata subsp. condensata, M. spicata var. crispa, M. spicata var. citrata, M. × gentilis, M. aquatic, M. arvensis a M. longifolia. Sledovanie veľkosti a počtu „žliazok typu Lamiaceae prispievaju k charakterizacii niektorych druhov Mentha (najma M. longifolia a M. × piperita.

  2. Li tter Fall i n A Pri mary an d Two Logged -over Lowland Tropical Rainfore sts in Pasirmayang, Jam bi.

    UPIK ROSALI NA WAS R IN

    1999-01-01

    Full Text Available Litte r accu mulatio n in a prim ary and a log g ed-ove r lo wland dipterocarp fore st at Pa si rmayang, Ja mbi wa s measu red u sin g the litte r trap met hod . In the p rimary fore st , tra p s were placed in fou r d istinc t areas, reflectin g th e su ccess ion stages of the fo rest fr om building t o mat u ration. In the logged-over fo re st , litter p roduc tion w a s measured at two differe nt si tes, one cut in 197 9/1980 a nd t h e second i n 1 983/1984. In the prim ary fore st , ave rage litter production during the ob serv ation period wa s 925 g m"2yr '. In the lo gged -over f o r e st , ave rage l itte r production wa s 721 g m '2 yr1 for t h e sit e cut in 1979 /198 0 and 70 6 g m '2 yr1 f o r the site cut in 19 83/1 984 . Leave s com p ri sed the major con tri butor of litter wit h 67% of tota l litter produced in t h e pri m ary forest, 67% of total litter i n the 1979/ 1980 cut log g ed-o ver fore st, and 65 % of total li tter in the 1983/1984 cut logged-over fore st . The pu rp ose of the stu dy wa s to use litte r fa ll a s a measure of forest pro ductivi ty to a ssess the recovery of log g ed -over forests and , t o pro v ide a basi s for co mpariso n o f forest-de rived land practices for app ropriate fo re st manage ment stra tegies .

  3. Polymorphisms of the pri-miR-34b/c promoter and TP53 codon 72 are associated with risk of colorectal cancer.

    Oh, Jisu; Kim, Jong Woo; Lee, Bo Eun; Jang, Moon Ju; Chong, So Young; Park, Pil Won; Hwang, Seong Gyu; Oh, Doyeun; Kim, Nam Keun

    2014-02-01

    The microRNA (miR)-34 family is a direct transcriptional target of tumor-suppressor TP53 and loss of miR-34 function may impair TP53-mediated cell cycle arrest and apoptosis. In the present study, we investigated whether the single nucleotide polymorphisms (SNPs) rs4938723 (T>C) in the promoter region of miR-34b/c and Arg72Pro (G>C) in codon 72 of TP53 are independently or complementarily associated with the risks and clinical outcomes of colorectal cancer (CRC) and whether the combined effect of these SNPs and metabolic risk factors are related to CRC. We evaluated the SNPs in 545 CRC patients and 428 healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequence analysis. We found that the GC and GC/CC genotypes of TP53 Arg72Pro were associated with decreased risk of CRC (adjusted OR = 0.727 for GC; OR = 0.735 for GC/CC). The combined genotypes of TT-GC and CC-GG were significantly associated with reduced CRC risk (adjusted OR = 0.628 for TT-GC; OR = 0.381 for CC-GG, respectively). The SNP rs4938723 and diabetes mellitus (DM) together were associated with an increased CRC risk, but the SNP TP53 Arg72Pro CC with DM showed a protective effect against CRC. These findings indicate that rs4938723 in the promoter region of pri-miR-34b/c and the SNP in TP53 codon 72 were related to decreased risk of CRC in the population studied and those metabolic diseases and genetic variants influence each other with regard to CRC susceptibility.

  4. A Radar Emitter Recognition Method Based on the PRI Switching Rules%一种基于PRI变化规律的雷达辐射源识别方法

    关一夫; 张国毅; 王晓峰

    2015-01-01

    针对相控阵雷达中某些具有复杂PRI调制样式的工作模式难以准确识别的问题,提出一种通过提取PRI序列变化规律来进行辐射源识别的方法。该方法借鉴了脉冲样本图的模型以及生物信息学中基因序列比对的动态规划思想,较好地解决了某些复杂PRI调制样式不好描述,以及相控阵雷达中一个完整工作模式包含脉冲序列长度太短,以致很难通过统计的方法对其进行准确识别的问题。仿真结果表明该算法的有效性,而且在存在脉冲丢失和干扰脉冲的情况下具有稳健性。%Focusing on the problem that phased-array radar has some modes with complex PRI modulation patterns are difficult to accurately identify,this paper proposes a recognition method by extracting the switching rules of the PRI sequence. This method draws on the pulse template model and the dynamic programming theory of bioinformatics in gene sequence alignment,having solved the difficulty in describing some complex PRI modulation pattern and those for statistical methods in recognizing phased-array radars with mode includes a complete sequence of pulses with very short length. Simulation results show the effectiveness of the algorithm and its robustness even in the presence of interference pulses and missing pulses.

  5. Support Group for Parents Coping with Children with Type 1 Diabetes / Skupina Za Starše Kot Podpora Družinam Pri Soočanju Z Otrokovo Sladkorno Boleznijo Tipa 1

    Pate Tanja

    2015-03-01

    Full Text Available Izhodišče. Sladkorna bolezen tipa 1 je ena izmed pogostejših kroničnih bolezni v otroštvu. Optimalno vodenje in presnovna urejenost otrokove sladkorne bolezni sta povezana z aktivno vključenostjo staršev/ skrbnikov, podporo otroku pri nadzoru nad boleznijo in funkcionalnostjo družine. Raziskava predstavlja oceno zadovoljstva staršev s programom skupine za starše in njihovo doživljanje vpliva omenjenega programa na življenje otroka in spoprijemanje z njegovo SBT1.

  6. Pri-Mir-34b/C and Tp-53 Polymorphisms are Associated With The Susceptibility of Papillary Thyroid Carcinoma: A Case-Control Study.

    Chen, Peng; Sun, Ruifen; Pu, Yan; Bai, Peng; Yuan, Fang; Liang, Yundan; Zhou, Bin; Wang, Yanyun; Sun, Yinghe; Zhu, Jingqiang; Zhang, Lin; Gao, Linbo

    2015-09-01

    Tumor suppressor p53 directly regulated the abundance of the miR-34b/c. The interaction might contribute to certain cancer. We hypothesized that rs4938723 in the promoter region of pri-miR-34b/c and TP-53 Arg72Pro may be related to the risk of papillary thyroid carcinoma (PTC). A total of 784 patients with PTC and 1006 healthy controls were recruited to participate in this study. The variants were discriminated using a polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). Additionally, the relative expression levels of miR-34b/c and TP-53 in 44 paired samples were revealed by quantitative reverse transcription polymerase chain reaction (qRT-PCR). A significantly increased risk of PTC was observed in the miR-34b/c rs4938723 CT, CC, and CT/CC genotypes compared with the TT genotype (CT vs TT: adjusted odds ratio [OR] = 1.51, 95%confidence interval [CI] = 1.23-1.85; CC vs TT: adjusted OR = 1.89, 95%CI = 1.39-2.63; CT/CC vs TT: adjusted OR = 1.59, 95%CI = 1.30-1.92, respectively). Significantly increased PTC susceptibility was also associated with the TP-53 Arg72Pro CC and CG/CC genotypes compared with the GG genotype (CC vs GG: adjusted OR = 2.04, 95%CI = 1.54-2.70; CG/CC vs GG: adjusted OR = 1.35, 95%CI = 1.11-1.67, respectively). Stratification analysis revealed that patients carrying the TP-53 Arg72Pro C allele and CC genotype had a significantly increased risk for developing N1 (C vs. G: OR = 1.27, 95%CI = 1.03-1.56; CC vs. GG: OR = 1.62, 95%CI = 1.07-2.46, respectively). Combined analysis showed that the genotypes of rs4938723 CT/CC + TP-53CG/CC increased the risk of PTC compared with rs4938723TT + TP-53GG (OR = 2.25, 95%CI = 1.67-3.03). Additionally, level of miR-34b was significantly upregulated in PTC patients.These findings indicate that the miR-34b/c rs4938723 and TP-53 Arg72Pro polymorphisms may contribute to the susceptibility of PTC.

  7. A Simple and High-Throughput Analysis of Amatoxins and Phallotoxins in Human Plasma, Serum and Urine Using UPLC-MS/MS Combined with PRiME HLB μElution Platform.

    Zhang, Shuo; Zhao, Yunfeng; Li, Haijiao; Zhou, Shuang; Chen, Dawei; Zhang, Yizhe; Yao, Qunmei; Sun, Chengye

    2016-05-04

    Amatoxins and phallotoxins are toxic cyclopeptides found in the genus Amanita and are among the predominant causes of fatal food poisoning in China. In the treatment of Amanita mushroom poisoning, an early and definite diagnosis is necessary for a successful outcome, which has prompted the development of protocols for the fast and confirmatory determination of amatoxins and phallotoxins in human biological fluids. For this purpose, a simple, rapid and sensitive multiresidue UPLC-MS/MS method for the simultaneous determination of α-amanitin, β-amanitin, γ-amanitin, phalloidin (PHD) and phallacidin (PCD) in human plasma, serum and urine was developed and validated. The diluted plasma, serum and urine samples were directly purified with a novel PRiME technique on a 96-well μElution plate platform, which allowed high-throughput sample processing and low reagent consumption. After purification, a UPLC-MS/MS analysis was performed using positive electrospray ionization (ESI+) in multiple reaction monitoring (MRM) mode. This method fulfilled the requirements of a validation test, with good results for the limit of detection (LOD), lower limit of quantification (LLOQ), accuracy, intra- and inter-assay precision, recovery and matrix effects. All of the analytes were confirmed and quantified in authentic plasma, serum and urine samples obtained from cases of poisoning using this method. Using the PRiME μElution technique for quantification reduces labor and time costs and represents a suitable method for routine toxicological and clinical emergency analysis.

  8. A Simple and High-Throughput Analysis of Amatoxins and Phallotoxins in Human Plasma, Serum and Urine Using UPLC-MS/MS Combined with PRiME HLB μElution Platform

    Shuo Zhang

    2016-05-01

    Full Text Available Amatoxins and phallotoxins are toxic cyclopeptides found in the genus Amanita and are among the predominant causes of fatal food poisoning in China. In the treatment of Amanita mushroom poisoning, an early and definite diagnosis is necessary for a successful outcome, which has prompted the development of protocols for the fast and confirmatory determination of amatoxins and phallotoxins in human biological fluids. For this purpose, a simple, rapid and sensitive multiresidue UPLC-MS/MS method for the simultaneous determination of α-amanitin, β-amanitin, γ-amanitin, phalloidin (PHD and phallacidin (PCD in human plasma, serum and urine was developed and validated. The diluted plasma, serum and urine samples were directly purified with a novel PRiME technique on a 96-well μElution plate platform, which allowed high-throughput sample processing and low reagent consumption. After purification, a UPLC-MS/MS analysis was performed using positive electrospray ionization (ESI+ in multiple reaction monitoring (MRM mode. This method fulfilled the requirements of a validation test, with good results for the limit of detection (LOD, lower limit of quantification (LLOQ, accuracy, intra- and inter-assay precision, recovery and matrix effects. All of the analytes were confirmed and quantified in authentic plasma, serum and urine samples obtained from cases of poisoning using this method. Using the PRiME μElution technique for quantification reduces labor and time costs and represents a suitable method for routine toxicological and clinical emergency analysis.

  9. Ostaliss pri svoihh / Aleksandr Shegedin

    Shegedin, Aleksandr

    2005-01-01

    Ülevaade Riigikogus toimunud pressikonverentsist, kus Riigikogu välisasjade komisjoni esimees Marko Mihkelson ja Venemaa Riigiduuma väliskomitee esimees Konstantin Kossatshov vastasid Eesti-Vene suhteid ning Riigiduuma delegatsiooni visiidi tulemusi puudutavatele küsimustele

  10. Animal Representations on Ceremonial Objects Found in the Tumulus at Črnolica pri Šentjurju at the Foot of Rifnik

    Iztok Vrenčur

    2013-07-01

    Full Text Available The years 1985 and 1986 saw a rescue excavation by archaeologists from the Institute for the Protection of Cultural Heritage of Slovenia, Celje Regional Office, performed on the severely damaged Iron Age tumulus in the village of Črnolica pri Šentjurju. The village lies in the close vicinity of the Rifnik hill, the site of one of the largest known hilltop settlements in Slovenia dating from the Late Bronze and Iron Ages. The excavation in Črnolica yielded a stone grave chamber of monumental dimensions, together with fragmented and decontextualised grave goods. These included a large set of quality ceramic vessels, a considerable number of bronze vessels, glass cups, fibulae, and a horse harness. Of special importance are three bronze items fabricated in Etruria, which carry the protomas of an aquatic bird, horses, and a ram. The burial dates to the Hallstatt C2 period or the second half of the 7th century BC. Aquatic birds are positioned on all four vertexes of the presentatoio, a special type of vessel presumably used for libation rituals. Comparable items have come to light in the richest graves of the Iron Age aristocracy of Etruria, Latium Vetus and Bologna, and date to the end of the 8th and the beginning of the 7th centuries BC. The aquatic bird sculptures on the presentatoio are stylised, displaying features of the Late Italic Geometric style. This motif marks various Late Bronze and Iron Age items associated with ritual activities in the greater part of Europe, connecting them with prehistoric religious beliefs. While the assumption that they refer to the sun divinisation cult is not proven, they must have signified some prehistoric aspect of the holy or numinous. The two anthropomorphic legs with an attached horse protoma found in the Črnolica tumulus were reconstructed as a part of a tripod of small dimensions, which can be classified as a member of the so-called horse tripod family, fine products of the Italic Geometric style

  11. Anxiety, Self-Esteem and Coping With Stress in Secondary School Students in Relation to Involvement in Organized Sports / Anksioznost, Samospoštovanje In Spoprijemanje S Stresom Pri Srednješolcih V Povezavi Z Vključenostjo V Organizirano Športno Aktivnost

    Dolenc Petra

    2015-09-01

    Full Text Available Cilj. Namen raziskave je bil preučiti raven samospoštovanja in anksioznosti ter uporabo različnih strategij spoprijemanja s stresom pri srednješolskih mladostnikih v povezavi z vključenostjo v redno in organizirano športno vadbo.

  12. Fazna ravnoteža alkalijskih nitrata (NaNO3, KNO3, RbNO3, CsNO3) u sustavu glicerol + H2O pri različitim temperaturama

    Zhang, H.-Y.; Li, S.-N.; Zhai, Q.-G.; Ou, Y.-M.; Jiang, Y.-C.; Hu, M.-C.

    2014-01-01

    Uređajem vlastite izrade mjerena je topljivost alkalijskih nitrata (NaNO3/KNO3/RbNO3/CsNO3) u smjesi otapala glicerol [HOCH2CH(OH)CH2OH] + H2O u ovisnosti o masenom udjelu glicerola (0,0 – 1,0) pri 35 i 45 °C. Određene su gustoće i indeksi loma zasićenih otopina NaNO3/KNO3/ RbNO3/CsNO3 + smjesa otapala glicerol + H2O. Eksperimentalni rezultati su pokazali da se s povećanjem masenog udjela glicerola u svim sustavima smanjuju topljivost soli i gustoća otopine, dok se indeks loma postupno poveća...

  13. 一种基于PRI变换的雷达信号分选方法研究%Research into A Radar Signal Sorting Method Based on PRI Transform

    徐梁昊; 姜秋喜; 潘继飞

    2014-01-01

    阐述了雷达信号分选的参数和方法,论述了直方图算法、脉冲重复周期(PRI)变换法的原理,研究了PRI变换法及其改进算法的性能,利用Matlab软件进行仿真实验,验证了改进后的PRI变换法能克服PRI抖动带来的信号分选困难,为下一步建立雷达对抗分选模型和采用主分选算法提供了参考依据.

  14. PRI变化雷达信号相位差变化率定位法研究%Research into The Location Methods of Phase Difference Rate to The Radar Signal with The Variational PRI

    张国毅; 宋德亮; 陈枫

    2010-01-01

    目前相位差变化率定位法的研究大都假设目标信号脉冲重复间隔(PRI)恒定,没有考虑到PRI变化引起的相位差变化率误差,而实际雷达信号PRI变化最为常见.研究了PRI变化信号的相位差变化率提取方法,比较了不同方法的相位差变化率估计精度.仿真结果表明采用最小二乘线性拟合法可以在各种PRI变化信号条件下达到较高的相位差变化率估计精度和定位精度.

  15. 基于TOA差值矩阵的雷达脉冲序列PRI识别方法%PRI Recognition Methods of Radar Pulse Sequences Based on TOA Difference Matrix

    张西托; 饶伟; 李长文

    2009-01-01

    针对雷达脉冲序列的主要特点,利用TOA(脉冲到达时间)差值矩阵探索PRI(脉冲重复间隔)的识别问题.设计了一种新方法,首先由TOA序列求出TOA差值矩阵,再求出TOA差值矩阵的逆矩阵,分析TOA差值矩阵逆矩阵的特殊结构,得到PRI的识别结果.通过研究重频固定、脉冲丢失和重频参差三种情况下的PRI识别问题,说明了该方法用于雷达脉冲序列PRI识别的可行性.

  16. Preliminary evidence for association of genetic variants in pri-miR-34b/c and abnormal miR-34c expression with attention deficit and hyperactivity disorder.

    Garcia-Martínez, I; Sánchez-Mora, C; Pagerols, M; Richarte, V; Corrales, M; Fadeuilhe, C; Cormand, B; Casas, M; Ramos-Quiroga, J A; Ribasés, M

    2016-08-30

    Attention deficit and hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder characterized by impairment to sustain attention and inability to control impulses and activity level. The etiology of ADHD is complex, with an estimated heritability of 70-80%. Under the hypothesis that alterations in the processing or target binding of microRNAs (miRNAs) may result in functional alterations predisposing to ADHD, we explored whether common polymorphisms potentially affecting miRNA-mediated regulation are involved in this psychiatric disorder. We performed a comprehensive association study focused on 134 miRNAs in 754 ADHD subjects and 766 controls and found association between the miR-34b/c locus and ADHD. Subsequently, we provided preliminary evidence for overexpression of the miR-34c-3p mature form in peripheral blood mononuclear cells of ADHD subjects. Next, we tested the effect on gene expression of single-nucleotide polymorphisms within the ADHD-associated region and found that rs4938923 in the promoter of the pri-miR-34b/c tags cis expression quantitative trait loci for both miR-34b and miR-34c and has an impact on the expression levels of 681 transcripts in trans, including genes previously associated with ADHD. This gene set was enriched for miR-34b/c binding sites, functional categories related to the central nervous system, such as axon guidance or neuron differentiation, and serotonin biosynthesis and signaling canonical pathways. Our results provide preliminary evidence for the contribution to ADHD of a functional variant in the pri-miR-34b/c promoter, possibly through dysregulation of the expression of mature forms of miR-34b and miR-34c and some target genes. These data highlight the importance of abnormal miRNA function as a potential epigenetic mechanism contributing to ADHD.

  17. An autoregulatory network between menin and pri-miR-24-1 is required for the processing of its specific modulator miR-24-1 in BON1 cells.

    Luzi, Ettore; Marini, Francesca; Ciuffi, Simone; Galli, Gianna; Brandi, Maria Luisa

    2016-05-24

    Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary cancer complex syndrome manifesting a variety of endocrine and non-endocrine neoplasms and lesions. MEN1 is characterized by tumours of the parathyroids, of the neuroendocrine cells of the gastroenteropancreatic tract, and of the anterior pituitary. The MEN1 gene, a tumour suppressor gene, encodes the menin protein. Loss of heterozygosity (LOH) at 11q13 is typical of MEN1 tumours in agreement with Knudson's two-hit hypothesis. We previously showed that the MEN1 parathyroid tumorigenesis is under the control of an "incoherent feedback loop" between miR-24-1 and the menin protein that generates a "Gene Regulatory Network" (GRN) that mimics the second hit of Knudson's hypothesis and that could buffer the effect of the stochastic factors that contribute to the onset and progression of this disease. Here we show, in the BON1 cell line derived from lymphnode metastasis of a human carcinoid tumour of the pancreas, that menin binds specifically to the primary RNA sequence pri-miR-24-1 by promoting the miR-24-1 biogenesis. Network simulation showed a new feed-forward loop between menin, microRNA-24-1 and Musashi-1 proteins. This result shows a novel mechanism whereby menin, a RNA-binding protein, facilitates the processing of its specific miRNA by regulating the dynamics of the menin-miR-24 Gene Regulatory Network at the level of pri-miRNA processing.

  18. Zakotvená teória ako východisko pri hľadaní učiteľových stratégií k udržaniu svojej roly v triede

    Csaba Igaz

    2013-10-01

    Full Text Available Článok sa zaoberá možnosťami využitia zakotvenej teórie pri kvalitatívnej analýze vyučovacích hodín s cieľom identifikovať rolu učiteľa a stratégie, ktoré umožňujú udržanie tejto roly. Takáto analýza sa môže využiť pri zavádzaní nových metód a prostriedkov do vyučovacieho procesu, kedy charakteristika rozdielov v správaní sa učiteľa počas bežnej vyučovacej hodiny a hodiny, v ktorej sa uplatňujú nové metódy nám umožní odhaliť ich slabé stránky. V príspevku sa podrobne venujeme postupu analýzy vyučovacích hodín. Na konkrétnych príkladoch vysvetlíme nielen aplikáciu otvoreného, axiálneho a selektívneho kódovania ale aj tzv. prechodnej úrovne kódovania, ktorá predstavuje nový prvok v zakotvenej teórií.

  19. Two common SNPs in pri-miR-125a alter the mature miRNA expression and associate with recurrent pregnancy loss in a Han-Chinese population.

    Hu, Yi; Liu, Chun-Mei; Qi, Lu; He, Tian-Zhu; Shi-Guo, Liu; Hao, Chan-Juan; Cui, Yi; Zhang, Ning; Xia, Hong-Fei; Ma, Xu

    2011-01-01

    Although there are plenty of evidence that single-nucleotide polymorphisms (SNPs) that fall within coding sequences of genes are involved in recurrent pregnancy loss (RPL), it is still unknown whether the polymorphisms in microRNAs (miRNAs) are related with RPL. In this study, we established this kind of association by confirming significant differences in genotype distribution of rs41275794 (P= 0.0005) and rs12976445 (P= 0.001) within the pri-miR-125a in 217 Han Chinese patients of RPL compared with 431 controls. Based on this observation, two-locus haplotypes were constructed and the A-T haplotype was found to be associated with an increased risk of RPL (OR=2.84, 95%C.I. 1.98-4.07, P=0.0000000057). Further analysis showed that the levels of pre- and mature- miR-125a were down-regulated in the cells transfected with the A-T haplotype, which was consistent with in vivo detection that the level of mature miR-125a was lower in 30 pregnant women with A-T haplotype than that with G-C haplotype. During in vitro RNA processing assays, we found a similar decrease in the amount of pre-miR-125a and decline in binding capacity of nuclear factors to pri-miR-125a with A-T haplotype. More importantly, the reduction in miR-125a, as a consequence of A-T haplotype, further led to less efficient inhibition of target genes, LIFR and ERBB2, which play important roles in the embryo implantation and decidualization. Thus, our data collectively suggest that two common polymorphisms in pre-miR-125a might contribute to the genetic predisposition to RPL by disrupting the production of miR-125a, which consequently interfered in the expression and function of target genes of miR-125a.

  20. Estimation of Chlorophyll Contents of Canopy with Advanced PRI Method%基于改进的PRI方法对植被冠层叶绿素含量的反演

    宁艳玲; 张学文; 韩启金; 杨宝祝

    2014-01-01

    叶绿素是植被光合作用的重要色素,对植被的健康状况有直接的指示作用。利用遥感技术准确、快速地获取植被叶绿素含量对精准农业具有重要意义。文章在对各种光化学植被指数(Photochemical Reflectance Index,PRI)与叶绿素含量进行敏感性分析的基础上,提取出对叶绿素变化较为敏感的组合形式,并考虑土壤背景的影响,提出了一种改进的PRI模型,同时利用在小汤山试验田获取的地面采样数据和实用模块化成像光谱仪(Operative Modular Imaging Spectrometer,OMIS)数据进行验证。结果表明,基于OMIS高光谱数据,模型能够很好地对植被冠层的叶绿素含量进行反演,反演的叶绿素含量与实测值具有较好的相关性。%Chlorophyll is an important photosynthesis pigment that directly indicates vegetation’s health status. Using remote sensing technology to estimate chlorophyll content accurately and quickly is important for precision agriculture. On the basis of sensitivity analysis between various photochemical reflectance index (PRI) and chlorophyll content, by extracting more sensitive combination form to chlorophyll and considering the impact of soil background, this paper proposes an improved PRI model. The study tries to use the ground sample data acquisition and synchronization Xiaotangshan airborne hyperspectral sensors OMIS (Operative Modular Imaging Spectrometer) data for validation. The results show that based on the OMIS hyperspectral data, the model can be well used to estimate the chlorophyll contents of vegetation canopy, which have good correlation with the measured values.

  1. Doenças priônicas: avaliação dos riscos envolvidos na utilização de produtos de origem bovina Prionic disease: evaluation of the risks involved in using products of bovine origin

    Omar Lupi

    2003-02-01

    Full Text Available Os príons são proteínas que se mostram capazes de auto-replicação apesar de, para isso, alterar o metabolismo celular. São responsáveis por inúmeras doenças em animais e no ser humano (doenças priônicas, todas elas fatais. Essas moléstias apresentam enorme variabilidade quanto ao período de incubação, de alguns meses a 40 anos. Os príons acumulam-se e destroem os neurônios, provocando quadros conhecidos como encefalopatias espongiosiformes. Discute-se a apresentação clínica, epidemiológica e histórica das doenças priônicas. O foco maior de discussão recai, no entanto, na possibilidade teórica da transmissão iatrogênica dos príons por meio das formulações tópicas que utilizam ceramidas (cerebrosídeos ou placenta de origem bovina, assim como pelo risco representado por alguns procedimentos dermatológicos, como transplantes da pele e implantes de colágeno.A prion is a protein that is capable of self replication, thereby altering a cell's metabolism. It is responsible for a number of human and animal diseases (prionic diseases, all of which are always lethal. These diseases have enormous variability in their incubation periods, ranging from a few months to forty years. Prions accumulate and destroy nerve cells, causing spongiform encephalopathy. We discuss the clinical picture, epidemiology, and historical background of prionic diseases. The major focus of the discussion lies, however, on the theoretical possibility of iatrogenic transmission of prion infection due to topical formulations using ceramides (cerebrosides or placenta of bovine origin, as well as the risk represented by some dermatological procedures such as skin grafts and collagen implants.

  2. Cold distribution networks. Cold distribution by two-phase refrigerant fluid. Case of ice slurries; Reseaux de distribution de froid. Distribution de froid par fluide frigoporteur diphasique. Cas du coulis de glace stabilisee (2002 - 2004). Rapport final (1er juillet 2004). Programme energie. PRI 9.1

    Lallemand, A. [Institut National des Sciences Appliquees (INSA), Centre de Thermique de Lyon (CETHIL), UMR 5008, 69 - Villeurbanne (France); Mercier, P. [CEA Grenoble, Groupement pour la Recherche sur les Echangeurs Thermiques (GRETH), 38 (France); Royon, L. [Paris-1 Univ., Lab. de Biorheologie et d' Hydrodynamique Physico-Chimique, 75 (France); Dumas, J.P. [L' Ecole Nationale Superieure en Genie des Technologies Industrielles, Lab. de Thermique Energetique et Procedes, 64 - Pau (France); Guilpart, J. [URGPAN/CEMAGRE, 33 - Bordeaux (France)

    2004-07-01

    This PRI aims to participate to the development of alternate solutions for refrigerant fluids, for the cold transport and more specially a two phase refrigerant fluid: the stabilized ice slurry. The research program presented three main axis: design, realization and characterization of stabilized ice slurry, experimental studies of transport and transfer properties, study of online measurement process of the solid content. A simulation has been realized to evaluate the energy efficiency of this refrigerant use. (A.L.B.)

  3. Association of Average Telomere Length with Body-Mass Index and Vitamin D Status in Juvenile Population with Type 1 Diabetes / Povezava Povprečnih Dolžin Telomerov Z Indeksom Telesne Teže in Vitaminom D Pri Mladostnikih S Sladkorno Boleznijo Tipa 1

    Tesovnik Tine

    2015-03-01

    Full Text Available Izhodišče. Sladkorna bolezen tipa 1 (SBT1 je kronična avtoimunska bolezen, pri kateri hiperglikemija ter zvišana raven oksidativnega stresa in končnih produktov glikacije skupaj z genetskimi in okoljskimi dejavniki privedeta do nastanka diabetičnih zapletov. Krajše dolžine telomerov so povezane s hiperglikemičnimi epizodami in nižjimi serumskimi vrednostmi vitamina D.

  4. vsiRNAs derived from the miRNA-generating sites of pri-tae-miR159a based on the BSMV system play positive roles in the wheat response to Puccinia striiformis f. sp. tritici through the regulation of taMyb3 expression.

    Feng, Hao; Zhang, Qiong; Li, Huayi; Wang, Xiaojie; Wang, Xiaodong; Duan, Xiaoyuan; Wang, Bing; Kang, Zhensheng

    2013-07-01

    Plants live in a complex environment, exposed to stresses, such as unsuitable climates, pests and pathogenic microorganisms. Pathogens are one of the most serious factors that threaten plant growth. Wheat stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is one of the most destructive diseases worldwide. Virus-induced gene silencing (VIGS) is a popular tool for the functional analysis of wheat genes, generating abundant small RNAs (sRNAs). sRNAs are key components in gene regulatory networks, silencing corresponding genes at the post-transcriptional level. In this study, we transduced pri-tae-miR159a into plant tissues using the barley stripe mosaic virus (BSMV) system, and demonstrated that vsiRNAs were generated from the same miRNAs generating sites of pri-tae-miR159a, with the function of Dicer RNase III-like classes of endonucleases (DCL4). In addition, the accumulation of vsiRNAs in wheat leaves challenged with Pst Chinese yellow rust 23 (CYR23), resulted in a resistant phenotype, and in the compatible interaction, the sporation of Pst was limited. Whereas, infection with a control construct had no effect on the resistance or susceptibility. The results of the histological observation also supported these phenotype changes. Interestingly, vsiRNAs were also involved in the interactions between wheat and Pst through the tae-miR159-mediated regulation of taMyb3 expression. Moreover, these results also supported the speculation that vsiRNAs were generated from the same sites of pri-tae-miR159a. These studies indicated that vsiRNAs from miRNAs generating sites of pri-tae-miR159a based on the BSMV system play positive roles in the wheat response to Pst through the regulation of taMyb3 expression.

  5. Effect of phase separation induced supercooling on magnetotransport properties of epitaxial La5/8−yPryCa3/8MnO3 (y≈0.4 thin film

    Sandeep Singh

    2015-02-01

    Full Text Available Thin films of La5/8−yPryCa3/8MnO3 (y≈0.4 have been grown on single crystal SrTiO3 (001 by RF sputtering. The structural and surface characterizations confirm the epitaxial nature of these film. However, the difference between the ω-scan of the (002 and (110 peaks and the presence of pits/holes in the step-terrace type surface morphology suggests high density of defect in these films. Pronounced hysteresis between the field cooled cooling (FCC and field cooled warming (FCW magnetization measurements suggest towards the non-ergodic magnetic state. The origin of this nonergodicity could be traced to the magnetic liquid like state arising from the delicacy of the coexisting magnetic phases, viz., ferromagnetic and antiferromagnetic-charge ordered (FM/AFM-CO. The large difference between the insulator metal transitions during cooling and warming cycles (TIMC ∼ 64 K and TIMW ∼ 123 K could be regarded as a manifestation of the nonergodicity leading to supercooling of the magnetic liquid while cooling. The nonergodicity and supercooling are weakened by the AFM-FM phase transition induced by an external magnetic field. TIM and small polaron activation energy corresponding the magnetic liquid state (cooling cycle vary nonlinearly with the applied magnetic field but become linear in the crystalline solid state (warming cycle. The analysis of the low temperature resistivity data shows that electron-phonon interaction is drastically reduced by the applied magnetic field. The resistivity minimum in the lower temperature region of the self-field warming curve has been explained in terms of the Kondo like scattering in the magnetically inhomogeneous regime.

  6. REVIEW OF RETRIEVAL LIGHT USE EFFICIENCY USING PHOTOCHEMICAL REFLECTANCE INDEX (PRI)%光化学植被指数估算植物光能利用率的研究进展

    吴朝阳; 牛铮

    2008-01-01

    应用遥感技术可以建立光化学植被指数(Photochemical reflectance index, PRI)和光能利用效率(Light use efficiency, LUE)的关系,LUE可用来估算净初级生产力(Net primary productivity, NPP).因而,用PRI估算植物的LUE,为估算NPP提供了新的方法,弥补了以往以经验模式通过温度和水分对最大LUE的胁迫来获取实际比LUE的不足,进而可提高NPP的估算精度.研究表明:PRI和LUE在叶片、冠层和景观尺度上都有着很好的相关性,但是随着尺度的变化,很多因素会对这一关系产生干扰,如水分、氮元素含量、叶面积指数和太阳高度角等,从而削弱了PRI和LUE的关系.该文对建立PRI和LUE的关系过程中的影响因素进行了分析,并指出今后这一研究领域中可能改进的方面,主要包括526nm和545nm处的反射率对531nm处的反射率的作用机制、PRI随LUE的饱和现象、PRI和LUE关系的时间效应以及利用PRI估算LUE的尺度效应.

  7. Vernost reprodukcije boja pri digitalizaciji slikovnih podataka

    Živković, Predrag; Vujaklija, Vanja

    2006-01-01

    This paper emphasis the importance of standardization of digitalization process, in the particular case digitalization the colorized object, when information of object color is of great impotence. Some prepositions for standardization of digitalization process of colorized objects are also explained.

  8. PRI EDZINO-NOMOJ EN HUNGARIO

    A.T.Trad.

    1997-01-01

    La edzini o signifas nomo an an eblon porla virinoj en Hungario.Sed tio estas ne deviga.ian elekton povas motivi pluraj vidpunktoj.Enla konservado de ia nomo povas roli ekzemptetio,ke i atus daǔrigi sian artan karieron kun

  9. Pri delezhke Tsheburashki mehh letit po storonam

    2007-01-01

    Vene ärimees ostab ameerika kompaniilt Films by Jove kollektsiooni nõukogude multifilmide (547 filmi) levitamisõigused, et anda need üle loodavale laste telekanalile Venemaal. Lähemalt laste multifilmide lemmikkangelasest Tsheburashkast, mille loojaks kirjanik Eduard Uspenski

  10. Pri la 81-a UK en Prago

    1996-01-01

    Antaǔtagmeze de la 21-a de aǔg.okazis enla mil-tura urbo Prago 1a 81-a Universala kon-greso de Esperanto kon prezidanto de la (?)e(?)aRespubliko s-ro Vaclav Havel kiel alta protek-tanto.UEA-prezidanto Lee Chong-Yeong

  11. Prevajanje termina ratio pri Varonu in Kvintilijanu

    Kozma Ahačič

    2000-12-01

    Full Text Available Termin (Lewandowski 1994: 1152-1153 je izraz, katerega pomen je enoznačno definiran. Vedno je v natančno opisanem razmerju z drugimi termini določene terminologije. Enopomenskost termina je, v nasprotju z običajnimi besedami, neodvisna od konteksta; lahko ga rabimo tudi izolirano. Ko postane beseda termin, zoži in specializira svoj (dotedanji pomen - tako rekoč izstopi iz svojih dotedanjih semantičnih povezav. Dobimo - če uporabimo izrazoslmje Umberta Eca - pomensko kastrirano besedo.

  12. Hiding the Higgs Boson from Prying Eyes

    Ma, Ernest

    2011-01-01

    There are two ways that the Higgs boson H of the Standard Model (SM) may be more difficult to observe than expected at the Large Hadron Collider (LHC) or the Tevatron. One is well-known, i.e. H decays invisibly, into dark-matter scalar particles for example. The other is that H mixes with a heavy singlet scalar S which couples to new colored fermions and scalars. Of the two mass eigenstates, the lighter one could (accidentally) have a suppressed effective coupling to two gluons, and the heavy one could be kinematically beyond the reach of the LHC.

  13. Tak prinjato pri demokratii / Julia Rodina

    Rodina, Julia

    2006-01-01

    Avatud Eesti Fondi poolt läbi viidud uuring demokraatia toimimisest Eestis: mitmed parlamendiliikmed peavad ajakirjandust segavaks faktoriks, mis seab ohtu demokraatia, politoloogide ja sotsioloogide hinnanud poliitikute ja meedia suhetest

  14. Precambrian crustal evolution and Cretaceous–Palaeogene faulting in West Greenland: 207Pb-206Pb dating of magnetite, monazite and allanite in the central and northern Nagssugtoqidian orogen, West Greenland

    Frei, Robert

    2006-12-01

    Full Text Available Pb-isotopic data for magnetite from amphibolites in the Nagssugtoqidian orogen, central West Greenland, have been used to trace their source characteristics and the timing of metamorphism. Analyses of the magnetite define a Pb-Pb isochron age of 1726 ± 7 Ma. The magnetite is metamorphic in origin, and the 1726 Ma age is interpreted as a cooling age through the closing temperature of magnetite at ~600°C. Some of the amphibolites in this study come from the Naternaq supracrustal rocks in the northern Nagssugtoqidian orogen, which host the Naternaq sulphide deposit and may be part ofthe Nordre Strømfjord supracrustal suite, which was deposited at around 1950 Ma ago.Pb-isotopic signatures of magnetite from the Arfersiorfik quartz diorite in the central Nagssugtoqidian orogen are compatible with published whole-rock Pb-isotopic data from this suite; previous work has shown that it is a product of subduction-related calc-alkaline magmatism between 1920 and 1870 Ma. Intrusion of pegmatites occurred at around 1800 Ma in both the central and the northernparts of the orogen. Pegmatite ages have been determined by Pb stepwise leaching analyses of allanite and monazite, and source characteristics of Pb point to an origin of the pegmatites by melting of the surrounding late Archaean and Palaeoproterozoic country rocks. Hydrothermal activity took place after pegmatite emplacement and continued below the closure temperature of magnetite at 1800–1650 Ma. Because of the relatively inert and refractory nature of magnetite, Pb-isotopic measurements from this mineral may be of help to understand the metamorphic evolution of geologicallycomplex terrains.

  15. Report of the PRI biofuel-ethanol; Rapport du PRI biocarburant-ethanol

    NONE

    2004-07-01

    This evaluation report presents three research programs in the framework of the physiological behavior of the yeast ''Saccharomyces cerevisiae'', with high ethanol content. These studies should allowed to select an efficient yeast for the ethanol production. The first study concerns the development of an enzymatic process for the hydrolysis and the fermentation. The second study deals with the molecular and dynamical bases for the yeast metabolic engineering for the ethanol fuel production. The third research concerns the optimization of performance of microbial production processes of ethanol. (A.L.B.)

  16. Treatment of linguiform calcaneus fracture by close nail-pry reduction and internal fixation with hollow screws%闭合撬拨复位经皮空心螺钉内固定治疗跟骨舌形骨折

    涂淑强; 黄科棣; 帅永明; 徐南云; 袁秋文; 郭剑

    2012-01-01

    Objective: To study the curative effects of close nail-pry reduction and internal fixation with hollow screws for treatment of linguiform calcaneus fracture. Methods: From May 2006 to October 2009,32 patients (35 feel) with linguiform calcaneus fracture were treated by close nail-pry reduction and internal fixation with hollow screws, including 23 males and 9 females ranging in age from 25 to 46 years, with a mean of 37.6 years. According to Paley classification, 3 cases were Paley II a, and 29 cases were Paley II b. All cases were close fractures. The time from injury to operation was 3 to 10 days after most swelling subsided. BBhler angle and Gissane angle were measured by X-ray before and after operation. The therapeutic effect was assessed according to ZHANG Tie-liang's foot score. Results:All the patients were followed-up for 6 to 18 months,with a mean of 12 months. All fractures gained bone healing. The time of fracture healing averaged 12 months. The fractures healed completely and no infection occurred. According to ZHANG Tie-liang's foot scale,the postoperative function was excellent in 18 feet,good in 10 feet, moderate in 5 feet and poor in 2 feet. The Bohler angle and Gissane angle were significant improved after treatment (P<0.01 ). Conclusion: The surgical method of close nail-pry reduction and internal fixation with hollow screws for treatment of linguiform calcaneus fracture can regain the foot function, with minimal injury, fewer complications, earlier recovery and lower costs.%目的:探讨闭合撬拨复位经皮空心螺钉内固定治疗跟骨舌形骨折的手术疗效.方法:自2006年5月至2009年10月共收治32例(35足)跟骨舌形骨折,男23例,女9例;年龄25~46岁,平均37.6岁.根据Paley分类法:PaleyⅡa型3例,PaleyⅡb型29例,均为闭合性骨折.手术时间为伤后3~10d,均等局部肿胀消退至中、轻度后手术.通过X线片测量手术前后B(o)hler角及Gissane角,并按张铁良足部综

  17. Metodologija postavljanja diferencijalnih jednačina pri istraživanju dinamičkih parametara konstrukcije lansirne rampe na vozilu točkašu / Methodology make of differential equations at investigation of dynamic parameters of constructions of launcher on vehicle

    Vlado P. Đurković

    2007-07-01

    Full Text Available U radu se određuju optimalni parametri konstrukcije lansirne rampe: položaj tačke vešanja hidrocilindra na rampi, dužina i materijal rampe, koeficijent viskoznog trenja ulja u hidrocilindru, koeficijent krutosti lansirne rampe i hidrocilindra, poprečni presek rampe, itd. Radi toga postavlja se mehanički model sa tri stepena slobode kretanja i odgovarajući model u vidu sistema od tri nelinearne diferencijalne jednačine drugog reda. Numeričkom analizom dobijenog matematičkog modela (primenom programskog jezika Compaq Visual Fortran, Version 6.5 dolazi se do optimalnosti pojedinih parametara. Dobijeni rezultati, predstavljeni u grafičkoj formi, mogu da budu veoma korisni projektantima raketnih lansera, kako stabilnih, tako i mobilnih, pri razvoju novih konstrukcija i modifikaciji postojećih. / This paper determines optimal construction parametrics of a missile launcher place of hydro-cylinder on launcher, length and material of ramp of launcher coefficient of the viscosity of friction oil in hydro-cylinder, coefficient of stiffness of launcher and hydro-cylinder, cross-section of launcher etc. In this purpose appointment mechanical model with three degrees of freedom motion and analogous model of system of three nonlinear differential equation second order. Numerical analysis obtained mathematical model (programming with language Compaq Visual Fortran, Version 6.5 coming to optimal parameters. Obtained results that are presented in graphical shapes can be very useful for designing stable and mobile missile launchers, both for development of new constructions and modification of existing structures.

  18. Funkcija jetre i bubrega pri trovanju molibdenom i bakrom

    Rana, S.V.S.; Kumar, A.

    1983-01-01

    Autori iznose rezultate testiranja funkcije jetre i bubrega (ukupni bilirubin, hipurna kiselina, glukoza-6-fosfataza, kolinesteraza, urea u serumu, albumin u mokraći, specifična težina mokraće i dilucijski test) koje su proveli da bi otkrili eventualna oštećenja jetre i bubrega štakora koji su primali hranu s dodatkom molibdena i bakra. Vrijednosti bilirubina u štakora hranjenih hranom s dodatkom bakra upućivali su na hemolizu. Niske razine hipurne kiseline također su ukazivale na oštećenje j...

  19. VPLIV NADZORA ZAPOSLENIH NA NJIHOVO VEDENJE IN MOTIVACIJO PRI DELU

    Marinšek, Teja

    2011-01-01

    Nadzor na delovnem mestu je sodoben problem, v katerem smo udeleženi vsi. Z vedno manjšim zaupanjem med nadrejenimi in podrejenimi se nadzor poostruje in s tem se tudi pritiski na delovnem mestu povečujejo. V diplomskem delu smo raziskovali predvsem vpliv nadzora na vedenje človeka. Zanimalo nas je, kako tak pritisk vpliva na človeka in njegove spremembe v obnašanju. Ali nanj to vpliva pozitivno in motivacijsko ali deluje na človeka negativno. Obravnavali smo tudi zakone, ki opredeljujejo...

  20. DISKRIMINACIJA PRI ZAPOSLOVANJU IN DELU NA PODLAGI SPOLNE USMERJENOSTI

    Markovič, Polona

    2012-01-01

    Ustavno zagotovljena pravica do enakosti, brez kakršnegakoli razlikovanja na podlagi osebnih okoliščin, predstavlja eno izmed temeljnih človekovih pravic. Za zagotavljanje enakega obravnavanja posameznikov in različnih skupin oseb na vseh področjih družbenega življenja je neizogibno potrebna natančna zakonska opredelitev varstva pred diskriminacijo. Prepoved diskriminacije je pravno regulirana v določilih mnogih dokumentov, sprejetih na mednarodni in nacionalni ravni. Diskriminacijo lahko naj...

  1. Kelke da aferoj pri Xu Shouzhen kaj Yang Fuchen

    Fu; Xianpei

    2000-01-01

    Antau 50 jaroj, la 7-an de decembro 1949, martiroj Xu Shouzhen(Eltunko) kaj Yang Fuchen(Yang Qiuzhen) oferis sian vivon al la movado por Esperanto kaj demokratio en Chengdu, la cefurbo de la provinco Sichuan. Xu Shouzhen estis kompetenta cina esperantisto. Komence de la 40-aj jaroj li venis de Chongqing al Chengdu kaj aktivis por nia lingvo. Tiam Li Shijun(Laulum) enhospitaligis en

  2. POMEN EMPATIJE PRI OBRAVNAVI PACIENTA V ENOTI INTENZIVNE TERAPIJE

    Knuplež, Urška

    2015-01-01

    Teoretična izhodišča: V enotah intenzivne terapije so pacienti v kritičnem stanju, zato je potrebno da znamo z njimi vzpostaviti primerno komunikacijo. Komunikacija medicinske sestre mora biti strokovna vendar tudi razumevajoča. To nam omogoča komunikacijska vrlina empatija. Empatija je sposobnost in proces skozi katerega se poskušamo postaviti v življenje in občutke druge osebe, ter gledati situacijo in njegovega zornega kota. Namen raziskave je bil ugotoviti koliko diplomiranih sester/ dipl...

  3. E-Voting and Forensics: Prying Open the Black Box

    Bishop, M.; Peisert, Sean; Hoke, S. Candice; Graff, Mark; Jefferson, David

    2009-01-01

    Over the past six years, the nation has moved rapidly from punch cards and levers to electronic voting systems. These new systems have occasionally presented election officials with puzzling technical irregularities. The national experience has included unexpected and unexplained incidents in each phase of the election process: preparations, balloting, tabulation, and reporting results. Quick technical or managerial assessment can often identify the cause of the problem, leading to a simple ...

  4. Zdravstvena nega onkološkega bolnika pri sistemski terapiji

    Korez, Sanja

    2014-01-01

    Onkološka zdravstvena nega je kompleksno in razvejano področje zdravstvene nege, na katerega vplivajo tudi druge specialne vede. Rak je splošno ime za obsežno skupino različnih bolezni, katerih glavna značilnost je nenadzorovana razrast spremenjenih, rakastih celic. Benigen tumor je grajen iz celic, podobnih normalnim, in lahko raste omejeno. Nasprotno pa so maligni tumorji rakasti. Grajeni so iz nenormalnih celic, ki se neurejeno in nenadzorovano širijo. Razraščajo se v sosednja tkiva in...

  5. Pri tofuo/tohuo/toǔfuo kai soikazeo

    AHN Song-san

    1997-01-01

    Manajoj el la t.n.sojfabo estas popularakaj gravaj en la orienta Azio,por inoj,japanojkaj koreoj.Science kaj praktike,la plantoj fabo kajsojfabo ne estas samaj legumenacaj specioj.Lavorto fabo(Vicia faba L.)estas uzata anka

  6. Bronzovaja medal pri "derevjannõhh" zarplatahh / Kirill Adejev

    Adejev, Kirill

    2006-01-01

    Rahvusvaheline firma Nau Group uuris juhtide sissetulekuid erinevates maades. Uuringu andmetel teenivad juhid Venemaal aastas keskmiselt 77,4 tuhat eurot ja on sellega firma poolt koostatud pingereas, kuhu kuulub 29 riiki, kolmandal kohal

  7. Desjatiletije galerei pri russkom teatre 11 maja / Liana Turpakova

    Turpakova, Liana

    2006-01-01

    Vene Draamateatri galerii korraldatud näituse "Natüürmort" avamine juveeligaleriis Bindes sõnas ja pildis. Fotod Aleksei Belovilt. Näitusega tähistati galerii kümnendat aastapäeva ja galerist Olga Ljubaskina sünnipäeva

  8. Identification of the sources of metal (lead) contamination in drinking waters in north-eastern Tasmania using lead isotopic compositions.

    Harvey, P J; Handley, H K; Taylor, M P

    2015-08-01

    This study utilises a range of scientific approaches, including lead isotopic compositions, to differentiate unknown sources of ongoing lead contamination of a drinking water supply in north-eastern Tasmania, Australia. Drinking water lead concentrations are elevated above the Australian Drinking Water Guideline (10 μg/L), reaching 540 μg/L in the supply network. Water lead isotopic compositions from the town of Pioneer ((208)Pb/(207)Pb 2.406, (206)Pb/(207)Pb 1.144 to (208)Pb/(207)Pb 2.360, (206)Pb/(207)Pb 1.094) and Ringarooma ((208)Pb/(207)Pb 2.398, (206)Pb/(207)Pb 1.117) are markedly different from the local bedrock ((208)Pb/(207)Pb 2.496, (206)Pb/(207)Pb 1.237). The data show that the lead in the local waters is sourced from a combination of dilapidated drinking water infrastructure, including lead jointed pipelines, end-of-life polyvinyl chloride pipes and household plumbing. Drinking water is being inadvertently contaminated by aging infrastructure, and it is an issue that warrants investigation to limit the burden of disease from lead exposure.

  9. Organizacija inžinjerijskih radova pri rušenju deonice puta / Organization of engineering works during demolition of a road section / Организация инженерных работ по демонтажу участков дорог

    Nenad V. Kovačević

    2016-01-01

    Full Text Available Prilikom upotrebe minsko-eksplozivnih sredstava za rušenje elemenata, materijala i objekata jako je bitna organizacija izvođenja radova prilikom pripreme i u toku izvođenja samog rušenja. Za izvođenje ovih radova u Vojsci Srbije postoje specijalizovane i namenske jedinice. Radi se o jedinicama jedne od specijalnosti u okviru roda inžinjerije, pionirske specijalnosti, koje egzistiraju u okviru inžinjerijskih bataljona, odnosno brigada KoV. Organizacija inžinjerijskih radova zapravo predstavlja iznalaženje najcelishodnijeg rešenja u pogledu upotrebe pokretnih stvari, ali i naprezanja ljudstva, pri rušenju konkretnog objekta – deonice puta. Pri tome veliki problem predstavlja literatura, a posebno norme za izvođenje radova, jer izuzev nekoliko skripti za internu upotrebu, sve se svodi na literaturu iz sedamdesetih ili početak osamdesetih godina prošlog veka. Posebno je razrađena primena mera zaštite prilikom upotrebe eksploziva. / When using explosive ordnance for the demolition of elements, materials and facilities, organization is very important in the preparation of works as well as during demolition itself. In the Army of Serbia, for this kind of works, there are specialized expert units within Land Forces engineering battalions or brigades. The organization of the engineering work given in the article is a purposeful solution, regarding the use of movable property and stress imposed on people as well, when performing demolition of a concrete structure - road section. Lack of literature is a big drawback, especially lack of norms for demolition works. Except for some unofficial lectures for internal use, most of the literature dates back to the seventies or early eighties. A special emphasis in this paper is given to the application of protective measures in the use of explosives. / В процессе применения минно-взрывных средств для сноса элементов, материалов

  10. Do PRI ao sistema plural na transição mexicana From PRI's hegemony to a plural system in the mexican transition

    Nelson Rojas de Carvalho

    1997-08-01

    Full Text Available Os resultados das eleições mexicanas de 6 de julho deste ano devem ser compreendidos à luz das políticas de ajuste e de reforma do Estado implementadas por De La Madrid e Salinas de Gortari. A reforma do Estado minou o partido de Estado: a perestroika mexicana acabou por produzir sua glasnostThe outcome of this year's Mexican elections must be understood from the perspective of the structural reform policies put into practice by presidents De La Madri and Salinas de Gortari. The reform of the State undermined the state party: the Mexican perestroika produced its own glasnost.

  11. Izkušnja razkritja pri istospolno usmerjenih odraslih in njihovih starših

    Hikel, Tadeja

    2015-01-01

    V diplomskem delu sem se osredotočila na istospolno usmerjene osebe, ki so svojo istospolno identiteto že razkrile svojim staršem in na starše, ki imajo za sabo že izkušnjo soočenja z otrokovo istospolno usmerjenostjo. Zanimalo me je predvsem, kako istospolno usmerjene osebe doživljajo lastno razkritje in kako starši doživljajo razkritje svojega otroka. V teoretičnem delu se osredotočam predvsem na nastajanje istospolne identitete, na njeno razkritje ter vpliv le tega na odnos starši – ot...

  12. Novi pristopi pri proučevanju prsti v pokrajini = New approaches in Slovenian soil geography

    Blaž Repe

    2006-01-01

    Full Text Available In Slovenia, soil research of a given landscape is often neglected in physical geography studies. Despite the fact of an equivalent position of soil geography within the science system of Slovene geography. Reasons can be found in time consuming fi eld research, expensive laboratory analysis and soil data and also the lack of its own methodology. The drawbacks could be partially replaced by different approaches of research and especially to establish links with other physical elements of the environment. The use of easily accessible digital and cartographic data, basic field techniques, in combination with simple GIS tools and quantitative methods overcomes many of the financial or time constraints.

  13. EFFEKTIVNOST' VNUTRISUSTAVNOGO VVEDENIYa GENTAMITsINA PRI PODAGRIChESKOM ARTRITE

    A. V. Orlov-Morozov

    2000-01-01

    Full Text Available Aim: То determine the efficacy of intraarticular injections of Gentamycin in gout arthtiris a randomized double blind, placebo-controlled trial was carried out. Material and methods: 27 patients answering the criteria of the definite gout diagnosis were randomly recruited from rheumatological clinic. The patients received an intraarticular injection of either 4- mg of Gentamycin in 4 ml of sterile 0.25% procaine or 5 ml of the vehicle alone. Results: It was found that weekly intraarticular injections of Gentamycin performed better than the inert vehicle alone over a 2-week period and were conjirmed during 4 week period of crossing-over. Conclusion: The possible mechanisms of Gentamycin activity are discussed. It is concluded, that intraarticular administration of Gentamicin offers signijicant benejit over placebo. The serious side effects were not obsen’ed. Therefore, the technique could be applied in the routine treatment of gout.

  14. Primena metoda ekspertskog ocenjivanja pri oceni profesionalnog rizika / Applying of expert method for professional risk rate

    Zoran Novaković

    2007-07-01

    Full Text Available Osnovni cilj utvrđivanja ocene profesionalnog rizika je preventivno delovanje u funkciji bezbednosti i zaštite zdravlja zaposlenih, tj. preduzimanje opštih i posebnih mera zaštite na radu radi eliminisanja opasnosti ili štetnosti ili smanjivanja vremena ekspozicije zaposlenog određenim faktorima rizika u sredinama gde je ustanovljena njihova prisutnost. U mnogim slučajevima raspoloživi podaci o prethodnim štetnim događajima su nepotpuni ili nisu dovoljno statistički relevantni. Zbog toga je skup ovih podataka najčešće statistički nehomogen, pa su i rezultati statističke analize, a time i procenjeni rizici, nedovoljno tačni i nepouzdani. Radi toga se u radu predlaže i primenjuje ekspertski metod koji poništava taj nedostatak, a istovremeno omogućava otklanjanje uticaja koji se odnose na neodređenost i subjektivnost pojedinačnih ocena. / The main goal of professional risk rate determination is preventive action in order to secure and protect health of employees. It considers assumption of common and special working protection measures in order to eliminate any danger or damage or to reduce workers exposition time to some risk factors in their working environments. In many cases data on former noxious events are incomplete or statistically insufficiently relevant. So the set of these data is often statistically nonhomogeneous, so are the results of statistical analysis. Thereby rated risks are insufficiently accurate and unreliable. Because of all these things, in this paper is recommend and apply an expert method which annuls this shortage and simultaneously it removes influences that are the consequence of some rate in determination and subjectivity.

  15. 用楔子撬开问题%Using a Wedge to Pry Open a Problem

    马提索夫

    2001-01-01

    When I elicited the Pumi word ts6 'wedge' in Kunming (March 1996), I was struck by its resemblance to Lahu jfl 'wedge'. Since the Qiangic languages are not particularly close to Loloish on the TB family tree,this apparent cognate for an item of non-core vocabulary was of interest. The first task in establishing a relationship between the Pumi and the Lahu forms was to reconstruct the PLB ancestor of Lahu jfi. Then possible cognates to the Pumi form in other Qiangic languages had to be examined.Given our present rudimentary knowledge of comparative Qiangic,could parallel examples establish a Proto-Qiangic reconstruction resembling our newly reconstructed PLB form?

  16. FLAVOUR - Friendly Location-aware Conference Aid with PriVacy Observant ArchitectURe

    Muthukrishnan, Kavitha; Meratnia, Nirvana; Lijding, Maria

    2005-01-01

    Context-aware applications are emerging on the daily basis and location information proves to be one of the key components to develop context-aware applications upon. This stems from the fact that location information enables and facilitates reasoning about what users are doing (user's behavioural p

  17. Razvoj odklanjala za rastrsko vodenje žarka pri laserskem označevanju:

    Babnik, Aleš; Bizjak, Aleš; Diaci, Janez

    2007-01-01

    This article presents the development of a new opto-mechatronic system that makes possible the laser marking of raster patterns consisting of several dotted lines. The processing laser beam in our new system is deflected in one direction by a hexagonal mirror prism rotating at a constant angular velocity.Each laser pulse produces a dot-shaped mark (a "laser dot") on the surface of the workpiece. By scanning the beam along a straight line we achieve a linear, uniformly distributed pattern of l...

  18. Razlike pri prevajanju nemško-slovenskih navodil za uporabo zdravil podjetja Bayer

    2014-01-01

    Diplomsko delo predstavlja analizo štirih navodil za uporabo zdravil družbe Bayer, ki se v lekarnah dobijo brez recepta. Besedila so pisana v strokovnem jeziku, kar pomeni, da jih je zaradi strokovne farmacevtske terminologije težje prevajati in zato potrebujejo dodatno pozornost. Kot že samo ime pove, je strokovni jezik v veliki meri namenjen stroki, obstajajo pa besedila, ki so kljub strokovnemu jeziku posplošena in namenjena laikom. Tako so besedila v tem diplomskem delu namenjena ljudem, ...

  19. Optimizatsiya i intensifikatsiya insulinoterapii pri sakharnom diabete 2 tipa (klinicheskie rekomendatsii

    I I Dedov

    2010-12-01

    Full Text Available По данным Государственного регистра больных сахарным диабетом, на 1 января 2009 года в России сахарный диабет (СД выявлен более чем у 3 миллионов человек, из них 2,7 миллиона приходится на 2 тип. Последние 15-20 лет интерес к выбору оптимальной терапии на всех этапах развития СД 2 типа возрастает. Это связано с одной стороны с появлением новых научных данных, а с другой стороны со всё увеличивающимися возможностями фармакологического воздействия у этой категории больных. В настоящее время специалисты выделяют 9 групп таблетированных и инъекционных препаратов. Эти данные представлены в одном из самых важных опубликованных за последнее время международных документов – совместном консенсусе Американской Диабетической Ассоциации (ADA и Европейской Ассоциации по исследованию диабета (EASD, а также в недавно опубликованном Консенсусе Американской Ассоциации Клинических Эндокринологов (AACE/ Американской Коллегии Эндокринологов (ACE. В этом обзорном документе специально оговаривается сравнение различных препаратов в виде следующего заявления: «В настоящее время недостаточно данных, чтобы поддержать рекомендацию по какому-то конкретному классу сахароснижающих препаратов или их комбинации в отношении влияния на предупреждение осложнений. Поэтому, справедливо судить и сравнивать сахароснижающие агенты, так же, как и их сочетание, в первую очередь по их способности снижать и поддерживать уровень HbA1c, а также по их безопасности, специфическим побочным эффектам, переносимости, удобстве в применении». Далее в документе подчеркивается особая роль инсулина в лечении СД, обосновывая это следующим: • инсулин является самым мощным сахароснижающим препаратом; • своевременное начало инсулинотерапии обеспечивает оптимальный контроль гликемии и, соответственно, улучшает прогноз СД 2 типа, замедляя развитие в организме необратимых изменений; • доказано влияние интенсивной инсулинотерапии на предупреждение развития сосудистых осложнений при диабете; • по мере прогрессирования диабета заболеванием труднее управлять; в этом плане инсулин даёт дополнительные преимущества, поскольку его действие не зависит от остаточной секреторной активности бета-клеток. В настоящих рекомендациях будут затронуты все этапы инсулинотерапии СД 2 типа: начало, оптимизация и интенсификация.

  20. Ocenjevanje displazije kolka pri odraslih: Assessment of hip dysplasia in adults:

    Mavčič, Blaž

    1999-01-01

    Degeneration of the articular cartilage and osteoarthritis of the hip joint are most often idiopathic (primary osteoarthritis). In patients with known pathogenesis (secondary osteoarthritis), the disease is most commonly due to mechanical bone deformation, termed hip dysplasia. The treatment is planned onthe basis of clinical, anatomic and biomechanical characteristics of the hipjoint. The biomechanical pattern is most frequently determined by the Wiberg centre-edge angle of lateral covering ...

  1. Ovlasti i obveze upravnog suca pri pretresu tužbe

    Massot, Jean

    2010-01-01

    Za prikazati što je specifično „dužnosti upravnog suca“ u zemljama kao što je Francuska, treba se osvrnuti na povijesni i zemljopisni prikaz. Izlaže se razloge postojanja upravnog suca u velikom broju demokratskih zemalja i onih koji koračaju prema demokraciji. Ističu se različitosti i specifičnosti upravnog suca u odnosu na ostale suce.

  2. PRAVNI POLOŽAJ ROMSKIH OTROK PRI IZOBRAŽEVANJU V PREKMURJU

    Vučko, Veronika

    2015-01-01

    Republika Slovenija vlaga precej naporov v vključevanje Romov v vrtce in obvezno šolo in v njihovo integracijo v večinsko kulturo na splošno. Predšolski otroci Romov so v slovenske vrtce vključeni na tri načine. Največ jih je integriranih v običajne oddelke. Kljub vsemu je značilen majhen delež romskih otrok, vključenih že v predšolsko vzgojo v vrtcih. Država posebej obravnava in šolam za vzgojo in izobraževanje romskih učencev priznava določene ugodnosti, ki jih bom deloma v nadaljevanj...

  3. Las campañas electorales del PRI en el Distrito Federal

    Héctor Tejera Gaona

    1999-01-01

    Full Text Available En este artículo se presenta la información derivada del seguimiento de tres campañas del Partido Revolucionario Institucional en el Distrito Federal, previas a las elecciones de julio de 1997. Con el propósito de evaluar el comportamiento ciudadano, se desagregan los diversos elementos que estuvieron en juego en dichas campañas. La información de la relación entre candidatos y ciudadanos es la base para realizar una reflexión sobre las posibilidades de hablar de una nueva cultura política. Se pretende mos¬trar algunos de los contenidos de dicha cultura con base en su expresión en el marco de la contienda electoral, formulando algunas propuestas sobre sus probables efectos en su interrelación con la acción partidaria y gubernamental

  4. "Pri tebi ne bo smelo biti reveža (5 Mz 15,4)"

    Skralovnik, Samo

    2015-01-01

    V obravnavanih mezopotamskih zakonikih, to so Ur-Nammujev, Lipit-Ištarjev, zakonik mesta Ešnunn in Hammurabijev, nobeden od omenjenih zakonodajalcev v pravnem besedilu ne omeni reveža. Zapišejo sicer nekaj besednih zvez, ki se temu približajo, kakor npr. človek v denarni stiski, vendar sama beseda revež ostaja neizrečena. Ob tem se moramo zavedati, da to dejstvo ni posledica šibkega besednega zaklada sumerščine oz. akadščine. Še več, opazimo lahko, da epilog Ur-Nammujevega ter ...

  5. PRI TEBI NE BO SMELO BITI REVEŽA (5 MZ 15,4)

    Skralovnik, Samo

    2009-01-01

    V obravnavanih mezopotamskih zakonikih, to so Ur-Nammujev, Lipit-Ištarjev, zakonik mesta Ešnunn in Hammurabijev, nobeden od omenjenih zakonodajalcev v pravnem besedilu ne omeni reveža. Zapišejo sicer nekaj besednih zvez, ki se temu približajo, kakor npr. človek v denarni stiski, vendar sama beseda revež ostaja neizrečena. Ob tem se moramo zavedati, da to dejstvo ni posledica šibkega besednega zaklada sumerščine oz. akadščine. Še več, opazimo lahko, da epilog Ur-Nammujevega ter prolog Hammurab...

  6. Miniature Electron Sources for Tomorrow’s Vacuum THz Devices (MiPRI)

    2006-07-01

    1957). ’F. S. Rusin and G. D. Bogomolov, Proc. IEEE 57, 720 (1969). :8L. A. Weinstein, Radiotekh. Elektron . (Moscow) 2, 883 (1957). 2D. E. Wortman and...following 5L. A. Weinstein, V. A. Isaev, and D. I. Trubetskov, Radiotekh. Elektron . condition: (Moscow) 28, 1233 (1983).6 M. B. Tseitlin and E. A. Myasin...Radiotekh. Elektron . (Moscow) 38, 961 X ej PO 582(1993). S> 155( )2 . (22) 7 V. L. Bratman, I. V. Bandurkin, B. S. Dumesh, A. E. Fedotov, Y K. -sk mfc 1

  7. UPORABA STANDARDA SIST EN ISO 13485:2012 PRI IZDELAVI INDIVIDUALNIH MEDICINSKIH VSADKOV

    Valand, Tomaž

    2013-01-01

    Organizacija, ki izdeluje individualne medicinske vsadke mora imeti vzpostavljen standard nadzora kakovosti v procesu izdelave. Treba je definirati metode in postopke zagotavljanja kakovosti, ki bodo v skladu s standardom ISO 13485. V prvem delu diplomske naloge je predstavljen standard in izdelava individualnega medicinskega vsadka. V drugem delu pa je predstavljena tehnologija izdelave vsadka. Rezultat diplomskega dela je oblikovana in za uporabo pripravljena vsa potrebna dokumentaci...

  8. Depresivnost in anksioznost pri mladostnikih z različnimi duševnimi motnjami:

    Groleger, Urban; Strah-Trotovšek, Darja; Tomori, Martina

    1996-01-01

    In the present study, depression and anxiety were evaluated in a sample of 81 secondary school-aged adolescents, hospitalised at the Adolescent Department, Centre for Mental Health, Ljubljana. The results were compared with those obtained in a control group of 122 secondary school students. The purpose of the study was to identify risk factors for adolescent anxiety and depressive disorders. Data were collected using a clinical interview, the Beck DepressionInventory - BDT and the State and T...

  9. Metoda EMDR kot pomoč policistom pri spoprijemanju s travmatskimi dogodki

    Muraus, Pamela

    2016-01-01

    Travmatski dogodki pogosto vodijo v razvoj posttravmatske stresne motnje – PTSM in so neizogibni del policijskega dela. Da je takšna motnja diagnosticirana in potrjena, mora izpolnjevati osem ključnih kriterijev Diagnostičnega in statističnega priročnika duševnih motenj (DSM − 5). Psihosocialna pomoč policistom je velikokrat spregledana, vendar podprta s podzakonskimi akti, ki jih ponuja njihova institucija. Novodobna metoda, znana pod imenom Desenzitizacija in ponovna predelava z očesnim gib...

  10. Presoja notranjih kontrol pri obračunu davka na dodano vrednost na primeru "Podjetja x"

    Majcen, Borut

    2016-01-01

    Poslovanje podjetja si je ob odsotnosti notranjih kontrol nemogoče predstavljati. Podjetja so podvržena raznim tveganjem, še posebej v današnjih razmerah globalnega poslovanja, ko se podjetja soočajo z vedno novimi izzivi, kar prinaša tudi nova tveganja. Najučinkovitejši ukrep za obvladovanje tveganj predstavlja vzpostavitev sistema notranjih kontrol. Obvladovanje tveganj pa ne poteka samo na ravni podjetja kot celote, ampak je prisotno na vseh področjih delovanja podjetja, torej tudi na p...

  11. UPORABA METOD UMETNE INTELIGENCE PRI ODZIVU NA IZREDNE DOGODKE V SISTEMU RAVNANJA Z ODPADKI

    Kropf, Peter

    2016-01-01

    Ravnanje z odpadki zajema zbiranje, prevažanje, predelavo in odstranjevanje odpadkov, vključno s kontrolo tega ravnanja. Izvajalci si zbiranje in odvoz organizirajo glede na potrebe in razpoložljive vire. Zaradi velikega števila odjemalcev, posod, vozil in voznikov se vnaprej pripravljajo urniki, ki so pripravljeni tako, da se viri znotraj podjetja izkoriščajo optimalno. V fazi izvajanja pogosto pride do nepredvidenih dogodkov, ki onemogočijo normalno izvajanje odvozov po urniku. V dip...

  12. VPLIV JOGE SMEHA NA NIVO GLUKOZE V KRVI PRI LJUDEH S SLADKORNO BOLEZNIJO TIPA 2

    Sternad, Simona

    2013-01-01

    Svetovna zdravstvena organizacija ocenjuje, da ima na svetu kar 246 milijonov odraslih ljudi (5,9 % prebivalstva) sladkorno bolezen, povečuje pa se tudi število otrok s to boleznijo. Dodatno ima še približno 308 milijonov odraslih moteno toleranco za glukozo (7,5 % prebivalstva), ki predstavlja predstopnjo v razvoju sladkorne bolezni, zato so nujni ukrepi za bolj učinkovito obvladovanje sladkorne bolezni. Sladkorno bolezen tipa 2 lahko preprečimo z zdravim načinom življenja. Vsakega posame...

  13. Sodelovanje med marketingom in R&R pri razvoju in uvajanju novih izdelkov:

    Završnik, Bruno; Zupančič, Vinko

    1998-01-01

    To succeed in today's marketplace, most companies must engender cooperation between marketing and R&D functions. Marketing and R&D share responsibilities for setting new product development goals, identifying opportunities for the next generation of product improvement, new engineering design, satisfying and understanding customer needs. Formal and informal integration (cooperation) between marketing and R&D is not guaranty for a successful new product development and introduction into the ma...

  14. Sodelovanje med marketingom in R&R pri razvoju in uvajanju novih izdelkov

    Završnik, Bruno; Zupančič, Vinko

    2015-01-01

    Uspeh podjetja na današnjih zahtevnih trgih je v veliki meri odvisen od sodelovanja med marketingom in R&R. Marketing in R&R si delita odgovornost za postavljanje ciljev razvoja novih izdelkov, iskanje možnosti za nove generacije izdelkov, nove oblike izdelkov, za razumevanje in zadovoljevanje potreb odjemalcev. Formalno in neformalno sodelovanje med marketingom in R&R samo po sebi še ne prispeva k uspešnemu razvoju in uvajanju novih izdelkov na trg. Vodstvo podjetja mora podpirati takšno sod...

  15. Bakteriološka zagađenost alginatnih otisaka i dimenzionalna stabilnost pri dezinfekciji

    Broz, Mira; Romić, Željko; Omrčen, Ante; Fridrih, Sandra; ROPAC, DARKO

    1989-01-01

    Istraživanje mikrobiološke zagađenosti alginatnih otisaka nametnulo je potrebu primjene dezinficijensa prije slanja otisaka u laboratorij. Kao praktično zadovoljavajuće pokazalo se petminutno potapanje otisaka u razrjeđenju od 1:50 klorheksidin-glukonata. Postavljen je problem točnosti uzetog otiska nakon dezinfekcije s obzirom na mogućnost utjecaja dezinfeciejnsa na volumen otiska. Originalnom metodom mjerenja otisne mase dokazano je da promjena volumena i površine alginata nije značajna te ...

  16. Trudovye resursy poslevoennoj Litvy i ih ispol'zovanie pri vosstanovlenii Klajpedy

    Kretinin G. V.

    2014-05-01

    Full Text Available This article focuses on the issues of post-WWII economic restoration effort in the Soviet Lithuania. German occupation of the republic caused significant damage to its industry and agriculture. Pre-war Lithuania was an agrarian state aspiring to embark on an industrial-agrarian path of development. After the war, this aspiration did not only persist, but was intensified. To reach this objective, however, Lithuania required qualified workforce. Before the war, hardly any attention was paid to the training of workers for industrial-scale production and construction. Then, a considerable decrease in population during the war aggravated the already substantial labour shortage. The attempts of the republic’s leadership to solve the problems of labour shortage through organised labour migration and labour mobilisation yielded no significant results. The appeals to the Centre with the request to send a substantial number of specialists and workers to Lithuania were heard, but a state ravaged by war did not have sufficient human resources. One of the solution was the use of labour of German prisoners of war. A network of prisoner-of-war camps was established in Lithuania. In a matter of two to three years, PWs completed a significant amount of work aimed at the rebuilding of important infrastructural objects. The case of Klaipeda is used to demonstrate the opportunities of the region and Centre in organising workforce in the Lithuanian SSR. The study uses the data obtained by modern historiography and documents kept in the Lithuanian State Central Archive.

  17. Rüütelkond hääbus, sest ei osanud PRi / Kaarel Tarand

    Tarand, Kaarel, 1966-

    2007-01-01

    Rets. rmt.: Jansen, Ea. Eestlane muutuvas ajas seisusühiskonnast kodanikuühiskonda. Tartu : Eesti Ajalooarhiiv, 2007 ; Vahtre, Lauri. Ajaloo pööripäevad I ja II. [Tallinn] : Tammerraamat, 2006 ; 2007

  18. Rahulolev töötaja teeb parimat PRi / Triin Rebane

    Rebane, Triin

    2006-01-01

    Siseturundus on panustamine oma töötajasse, aidates luua firmas positiivse sisekliima, mis annab firmale konkurentsieelise ükskõik millises ärivaldkonnas. Kommenteerib Katrin Alujev. Vt. samas: Maris Lindmäe. Hea meediakoolitus järgib konkreetse kliendi vajadusi; Kaja Pino. Ära unusta pühade ajal töötajaid

  19. Otkrõtije vernisazha "Kak prekrasen etot mir" v galereje pri gostinitse Vana-Wiru

    2008-01-01

    Peterburi kunstniku Marina Printseva tekstiilpiltide ja Odessast pärit kunstniku Juri Gorbatshovi tööde näituse "Kui kaunis on see maailm!" avamine Tallinnas hotell "Vana Wiru" fuajees. Fotod näituse avamiselt

  20. Obrazovanie Vzroslykh pri Probleme Dosuga (Adult Education and the Problem of Leisure)

    Darinskii, Anatolii V.

    1969-01-01

    Adult education in the Soviet Union must find flexible new methods, preferably including tourism or other elements of recreation, to raise adults' cultural standards and intellectualize their free time while helping them improve their work qualifications and professional skills. (Author/LY)

  1. Pri vsem bogatstve võborov alternativõ net / Jevgenija Garanzha

    Garanža, Jevgenija, 1979-

    2005-01-01

    Rahvaliit, Keskerakond ja Reformierakond teevad ettevalmistusi algavateks võimukõnelusteks. Turu-uuringufirma Saar Poll poolt läbiviidud uuringust, mille käigus küsiti inimeste arvamusi, kuidas nad käituksid, kui Riigikogu valimised toimuksid homme

  2. Metode socialnega dela s starimi ljudmi in njihova uporaba pri delu z ljudmi z demenco:

    Ambrožič, Maja; Mohar, Špela

    2015-01-01

    Aging population requires new methods of work with older people, forcing us to discover new ways to cope with the challenges posed by aging and old age. The multidisciplinary integration of disciplines is very important because it contributes to the quality of aging and gives older people a voice. Working with the elderly is specific and, specifically in social work, encompasses an important space of research and interweaves theory with practice. In this context, it is necessary to rely on th...

  3. Nonisothermic filtering in working oil fields. Neizotermicheskaya fil'tratsiya pri razrabotke neftyanykh mestorozhdeniy

    Alishayev, M.G.; Rozenberg, M.D.; Teslyuk, Ye.V.

    1985-01-01

    A description is made of the effect of water injected in large volumes at low temperature on the development indicators and the oil output coefficient, as well as their dependence on the thermal methods of bed modification. An examination was made of the mechanism for displacing oil from the beds during thermal flooding, temperature mode of the bed beyond the displacement front and in those regions where there is no displacement front. Examples are given of determining the filtering indicators and the technical and technological indicators of working in displacement of oil by water.

  4. Uloga bolesti i štetnika pri odabiru drveća u krajobraznoj arhitekturi

    2005-01-01

    Poznavanje vrsta drveća i njihove osjetljivosti na pojedine bolesti i štetnike, u specifičnim ekološkim uvjetima, od izuzetne je važnosti za njihov odabir u krajobraznoj arhitekturi. Istraživanjima tijekom zadnjih godina u Hrvatskoj zapaženi su značajni problemi sa zdravstvenim stanjem drveća u šumskim ekosustavima, uzrokovani poznatim i do sada manje poznatim uzrocima. U urbanim sredinama utvrđene su slične i još naglašenije promjene na nekim vrstama drveća. Ona su podvrgnuta različitim štet...

  5. ZONA OŠTEĆENJA STIJENSKE MASE PRI ISKOPU TUNELA MINIRANJEM

    Antičević, Hrvoje; Dobrilović, Mario; Perković, Hrvoje

    2012-01-01

    Izrada podzemnih rudničkih prostorija, tunela i odlagališta radioaktivnog otpada, podrazumijevaju primjenu jednakih odnosno sličnih tehnologija. Uslijed iskopa tunela miniranjem dolazi do određenog stupnja oštećenja stijenske mase oko konture presjeka iskopa. Oštećenja stijenske mase koja nastaju u neposrednoj okolini konture presjeka tunela izražene su proširenjem postojećih i stvaranjem novih pukotina, odnosno promjenom fizičko-mehaničkih svojstava stijenske mase. Prilikom izrade dubokih ge...

  6. Sensor4PRI: A Sensor Platform for the Protection of Railway Infrastructures

    Eduardo Cañete

    2015-02-01

    Full Text Available Wireless Sensor Networks constitute pervasive and distributed computing systems and are potentially one of the most important technologies of this century. They have been specifically identified as a good candidate to become an integral part of the protection of critical infrastructures. In this paper we focus on railway infrastructure protection and we present the details of a sensor platform designed to be integrated into a slab track system in order to carry out both installation and maintenance monitoring activities. In the installation phase, the platform helps operators to install the slab tracks in the right position. In the maintenance phase, the platform collects information about the structural health and behavior of the infrastructure when a train travels along it and relays the readings to a base station. The base station uses trains as data mules to upload the information to the internet. The use of a train as a data mule is especially suitable for collecting information from remote or inaccessible places which do not have a direct connection to the internet and require less network infrastructure. The overall aim of the system is to deploy a permanent economically viable monitoring system to improve the safety of railway infrastructures.

  7. Medsebojno delovanje zdravil pri starostnikih: Drug drug interactions in the elderly:

    Trontelj, Jurij

    2010-01-01

    Elderly patients commonly suffer from comorbidities and often take 4 or more drugs simultaneously. Polypharmacy poses a significant risk for drug-drug interactions. Elderly patients tend to eliminate drugs more slowly and they are more sensitive to drugsć adverse effects at the same time. The most important consequences of drug drug interactions that often require hospitalization are gastrointestinal bleeding, acute bradicardia, hypotension,arrhythmias and falls associated with use of psychot...

  8. VPLIV UPORABE E-GRADIV NA USPEH UČENCEV PRI PREDMETU GEOGRAFIJA

    Škof, Iztok

    2013-01-01

    S spremembami na različnih znanstvenih, kulturnih in socialnih področjih so se spremembe pojavile tudi v izobraževalnih sistemih in njihovih glavnih elementih, kot so izobraževalni cilji, metode poučevanja, načini ocenjevanja, in v učnih načrtih. Danes v izobraževalnih ustanovah poučevanje-učenje ne sme biti omejeno na učbenike oz. učitelje, ampak moramo omogočiti vseobsegajoče vseživljenjsko izobraževanje. E-učenje to omogoča. Namen magistrske naloge je raziskati vpliv e-gradiv, dostop...

  9. Terapija s pomočjo konja pri motnjah avtističnega spektra

    Purgaj, Natalija

    2014-01-01

    Motnja avtističnega spektra je biološko utemeljena, pervazivna razvojna motnja v različno težkih oblikah. Prisotno je nenormalno ali moteno vedenje, ki se kaže pred tretjim letom starosti. Težave so značilne na socialnem področju, v interakciji, komunikaciji, pojavlja se utesnjeno, stereotipno, ponavljajoče se vedenje. Prisotne so lahko tudi druge nespecifične težave. Motnja avtističnega spektra ni ozdravljiva, lahko pa se blažijo njeni simptomi z raznimi edukacijami, modifikacijskimi vedenji...

  10. Isotopic signatures for natural versus anthropogenic Pb in high-altitude Mt. Everest ice cores during the past 800 years.

    Lee, Khanghyun; Hur, Soon Do; Hou, Shugui; Burn-Nunes, Laurie J; Hong, Sungmin; Barbante, Carlo; Boutron, Claude F; Rosman, Kevin J R

    2011-12-15

    A long-term record, extending back 800 years (1205 to 2002 AD), of the Pb isotopic composition ((206)Pb/(207)Pb and (208)Pb/(207)Pb) as well as Pb concentrations from high altitude Mt. Everest ice cores has the potential to identify sources and source regions affecting natural and anthropogenic Pb deposition in central Asia. The results show that the regional natural background Pb isotope signature (~1.20 for (206)Pb/(207)Pb and ~2.50 for (208)Pb/(207)Pb) in the central Himalayas was dominated by mineral dust over the last ~750 years from 1205 to 1960s, mostly originating from local sources with occasional contributions of long-range transported dust probably from Sahara desert and northwestern India. Since the 1970s, the Pb isotope ratios are characterized by a continuous decline toward less radiogenic ratios with the least mean ratios of 1.178 for (206)Pb/(207)Pb and 2.471 for (208)Pb/(207)Pb in the period 1990-1996. The depression of the (206)Pb/(207)Pb and (208)Pb/(207)Pb values during the corresponding periods is most likely due to an increasing influence of less radiogenic Pb of anthropogenic origin mainly from leaded gasoline used in South Asia (India as well as possibly Bangladesh and Nepal). From 1997 to 2002, isotopic composition tends to show a shift to slightly more radiogenic signature. This is likely attributed to reducing Pb emissions from leaded gasoline in source regions, coinciding with the nationwide reduction of Pb in gasoline and subsequent phase-out of leaded gasoline in South Asia since 1997. An interesting feature is the relatively high levels of Pb concentrations and enrichment factors (EF) between 1997 and 2002. Although the reason for this feature remains uncertain, it would be probably linked with an increasing influence of anthropogenic Pb emitted from other sources such as fossil fuel combustion and non-ferrous metal production.

  11. PRI: transport and distribution networks of the electric power. Research program 2002/2003 (one year); PRI: Reseaux de transport de et de distribution de l'energie electrique. Programme de recherche 2002 / 2003 (1 an)

    NONE

    2004-07-01

    This program proposes two actions. The first one deals with the energy transfers in networks. The study presents the control of networks in the new context of the deregulation which will imply a massive insertion of a decentralized production and the research of new tools of networks simulation using the new analysis methods by order reduction and fractals. The second one is devoted to the high voltage electronic and the energy transfer. (A.L.B.)

  12. 对基于PRI谱计算脉冲重复间隔的一种改进方法%An improved method of estimating PRI based on PRI spectrums

    王文光; 常伟光; 王俊

    2006-01-01

    通过PRI变换可以得到PRI谱图,基于PRI谱估计脉冲重复间隔是一种有效的方法,具有很广的应用范围,但也有其局限性.本文针对PRI谱方法对参差雷达的PRI估计效果不理想的情况,结合脉冲列的自相关和一阶直方统计给出了一种改进方法.这种改进方法不仅保留了PRI谱方法的优点,对参差雷达也得到了很好的估计结果.

  13. Performance Analysis of PRI Transform in theRadar Pulse Signal's PRI Detection%PRI变换对脉冲雷达信号PRI检测的性能分析

    安振; 李运祯

    2007-01-01

    传统的雷达脉冲列去交错算法很容易出现信号的脉冲重复间隔及其整数倍(即子谐波)同时存在的现象,给雷达脉冲串的去交错造成了困难.介绍了PRI变换的脉冲重复间隔估计算法,该算法几乎完全抑制了出现在自相关函数中的子谐波,同时研究了该算法对稳定重频、抖动重频、参差重频、滑变重频等各类信号的PRI检测性能.计算机仿真结果表明,这种算法适用性较强.

  14. NAPAČNA RAZUMEVANJA PREPROSTIH NARAVOSLOVNIH POJMOV PRI VZGOJITELJICAH IN ŠTUDENTIH PREDŠOLSKE VZGOJE

    Breznik, Nika; Božič, Manja

    2014-01-01

    Pojem je miselna tvorba, ki je določena z bistvenimi lastnostmi in značilnostmi. Pojme razvijamo skozi proces učenja, ki traja celo življenje, nanj pa vplivajo različni dejavniki. Pojme razvijamo postopoma in prilagojeno miselnemu razvoju posameznika. Diplomsko delo govori o napačnem razumevanju preprostih naravoslovnih pojmov. Diplomsko delo je sestavljeno iz teoretičnega in empiričnega dela. V prvem delu smo se osredotočili na kognitivni razvoj otroka, učenje in razvoj pojmov. Posebno pozor...

  15. Limited access to HIV prevention in French prisons (ANRS PRI2DE: implications for public health and drug policy

    Blanche Jerôme

    2011-05-01

    Full Text Available Abstract Background Overpopulation, poor hygiene and disease prevention conditions in prisons are major structural determinants of increased infectious risk within prison settings but evidence-based national and WHO guidelines provide clear indications on how to reduce this risk. We sought to estimate the level of infectious risk by measuring how French prisons adhere to national and WHO guidelines. Methods A nationwide survey targeting the heads of medical (all French prisons and psychiatric (26 French prisons units was conducted using a postal questionnaire and a phone interview mainly focusing on access to prevention interventions, i.e. bleach, opioid substitution treatment (OST, HBV vaccination and post-exposure prophylaxis (PEP for French prisoners. Two scores were built reflecting adherence to national and WHO international guidelines, ranging from 0 (no adherence to 10 (maximum adherence and 0 to 9 respectively. Results A majority (N = 113 (66% of the 171 prisons answered the questionnaires, representing 74% coverage (46,786 prisoners of the French prison population: 108 were medical units and 12 were psychiatric units. Inmate access to prevention was poor. The median[IQR] score measuring adherence to national guidelines was quite low (4.5[2.5; 5.5] but adherence to WHO guidelines was even lower 2.5[1.5; 3.5]; PEP was absent despite reported risky practices. Unsuitable OST delivery practices were frequently observed. Conclusions A wide gap exists between HIV prevention policies and their application in prisons. Similar assessments in other countries may be needed to guide a global policy reform in prison settings. Adequate funding together with innovative interventions able to remove structural and ideological barriers to HIV prevention are now needed to motivate those in charge of prison health, to improve their working environment and to relieve French prisoners from their currently debilitating conditions.

  16. Diurnal Patterns of Photosynthesis, Chlorophyll Fluorescence, and PRI to Evaluate Water Stress in the Invasive Species, Elaeagnus umbellata Thunb

    2010-01-01

    effective quantum yield of pho- tosystem II: DF=F0m ¼ F0m Fs =F0m 238 Trees (2010) 24:237–245 123 Leaf xylem pressure potentials (W) were...with ontogenic changes in water limited Chenopodium quinoa leaves. Photosynthetica 40:227–232 Yates ED, Levia DP Jr, Williams CL (2004) Recruitment of

  17. Kritična analiza diskurza pri tolmačenju za skupnost v Sloveniji: doktorska disertacija:

    2015-01-01

    The thesis explores community interpreting in Slovenia with special regard to the specifics of interpreter-mediated interaction and the role of interpreting in institutional settings. The doctoral project aims to present the field and show the significance of interpreters' work, their professional competence and the understanding of this process in facilitating successful communication. The study argues that: a) interpreting and institutional discourse influence each other reciprocally; b) in...

  18. Hidrokinezioterapija v primerjavi s kinezioterapijo pri starejših osebah po vstavitvi totalne endoproteze kolčnega sklepa

    Jakovljević, Miroljub; Vauhnik, Renata

    2015-01-01

    Background: Aquatic therapy allows secure, active exercise with pain reduction using a combination of the water's buoyancy, hydrostatic pressure resistance and warmth. By aquatic therapy, elderly patients after total hip replacement can achieve more positive effects than by land-based exercise. The aim of the study was to investigate the use of aquatic-based exercises in the rehabilitation programme after a hip fracture surgery in elderly adults. Results: Both groups, regardless of the type o...

  19. PRI-CAT: a web-tool for the analysis, storage and visualization of plant ChIP-seq experiments.

    Muino, J.M.; Hoogstraat, M.; Ham, van R.C.H.J.; Dijk, van A.D.J.

    2011-01-01

    Although several tools for the analysis of ChIP-seq data have been published recently, there is a growing demand, in particular in the plant research community, for computational resources with which such data can be processed, analyzed, stored, visualized and integrated within a single, user-friend

  20. Vloga in pomen ustvarjalnega pisanja pri pouku književnosti v osnovni šoli: doktorska disertacija:

    Blažić, Milena Mileva

    2000-01-01

    The thesis presents the meaning and role of creative writing in teaching literature in elementary school. The first theoretical part discusses contemporary cognitive theory in which writing itself is a process as important as the text. Since the traditional conception of writing was centered on the result of the writing process – the text. The cognitive writing model is composed of three parts: 1. task environment; 2.the writers’ long term memory and 3. writing process. In addition two writin...

  1. Statistical methods for processing seismic information and studying complicated media. Statisticheskiye metody obrabotki seysmicheskoy informatsii pri issledovanii slozhnykh sred

    Troyan, V.N.

    1982-01-01

    For the first time materials are generalized concerning statistical methods of processing seismic information which are used more widely in prospecting minerals (oil, gas, ore) in regions of complex structure and great depths. The methods provide reliable identification of useful signals in the background of interferences. Fundamentals are examined of methods of constructing algorithms and programs used in interpretation, and their efficiency.

  2. Izbrani kazalci obremenjenosti okolja pri študijah ranljivosti okolja = Selected environmental pollution indicators in environmental vulnerability studies

    Dejan Cigale

    2002-01-01

    Full Text Available One of the components of the environmentalvulnerability studies is also the evaluation of the pollution of theenvironment. In the article, the analysis of the selected indicators of theachieved degree of the total and integral pollution is presented. In theframework of the environmental vulnerability studies on the spatial levelof landscape-ecological types for this purpose the following indicatorswere selected: population density, density of working places, trafficintensity and percentage of forests.

  3. Vloga finančnih omejitev pri poslovanju na tujih trgih = The Role of Financial Constraints on Foreign Markets

    Crt Kostevc

    2006-12-01

    Full Text Available The Role of Financial Constraints on Foreign MarketsAbstract: Recent research on the role of foreign activities and their impact on firm characteristics has, with few exceptions, confirmed the existence of persistently large differences between exporters and non-exporters in terms of size, investments, innovative activity etc. In spite of the mounting evidence on the advantages of exporters over firms focused solely on their domestic markets, the source of these differences is yet to be explained. The present contribution attempts to analyze the role of financial constraints as one of the factors determining which firms will export and which will not. Through a survey of the existing literature, the role of financial constraints that limit foreign market access to only a subset of the firms, will be revealed. It is shown that financial constraints – even when other factors are explicitly considered (such as firm size, productivity, capital intensity, . . . – to a large extent determine the firms that will be able to enter into foreign markets, and also mean that financially constrained firms end up exporting less frequently and in smaller quantities than could otherwise be expected.

  4. The Effect o f Twelve - Week Recreation Act i v ities on the Anxiety Level of Female Pri soners

    Zekiye B AŞARAN

    2015-07-01

    Full Text Available T h e a i m o f t h e s t u d y w a s to examine the effect of twelve - weeks recreation activities on the trait anxiety level of female prisoners in the prisons. The sampling of this study consists of 45 female prisoners who are in the Open Prison in Kandira, 22 of whom are in the experimental group and 23 of whom are in the control group. Different activities, such as music, dance, meditatio n, sportive activities, movies and videos, fun and entertainment activities and competitions, were performed one and half hours a day and two days a week. This lasted for twelve weeks. The data were collected by pre - tests and post - tests that were given bo th at the beginning and at the end of this program. Personal information form and Spielberger anxiety inventory were used as the data collecting tool. The reliability coefficient (Cronbach Alpha was calculated as ,873. The data were analysed with SPSS Win dows 18 programme. Descriptive statistics and Wilcoxon test were conducted. A si gnificant statistical correlation was determined between the prisoners’ pre - tests and post - tests scores in the experimental group (p <0.05. A s c o n c l u s i o n , a positive impact on trait anxiety levels of prisoners w a s f o u n d a f t e r 12 weeks o f recreational activities.

  5. Implementacija sistemskih organizacijskih postavitev pri ustanovitvi računovodskega podjetja Aktiva 3000 d.o.o.

    2016-01-01

    Drznost in inovativnost nam dajeta moč, da raziščemo in prikažemo kako lahko z metodo organizacijske sistemske postavitve dobimo nove, sveže uvide v procesu ustanavljanja računovodskega podjetja. Vsak organizacijski sistem se začne z idejo, namenom, cilji, poslanstvom in vizijo. Predstavljamo svojo idejo, kaj delati, kako delati, postavili smo si cilje, preverili svoje zmožnosti, analizirali konkurenco, analizirali, kako deluje trg, analizirali smo vsako podrobnost, ki vpliva na uspešn...

  6. Kalibrowka 900- kanalxnogowremqproletnogo detektoraiizmereniespektrowadronow wowzaimodejstwiqhqder pb+pb pri “nergii 158 g“w / nuklon

    Kolesnikov, V I

    This paper explains in detail the layout and characteristics of TOF-L detector (part of NA49 and NA61 experiments), calibration procedure used, as well as application of acquired information in analysis of collisions of lead-lead nuclei

  7. PROJECTION OF PENETRATION OF THE BROKER IN HOME BRAZILIAN CAPITAL MARKET THROUGH LINEAR, GOMPERTZ AND FISHER – PRY MODELS

    Carlos Kawamoto

    2010-09-01

    Full Text Available This paper aims to discuss the theories of internationalization and competitiveness, the positioning of a Brazilian company from agribusiness industry, exporting meat and food that has become a major global player in this industry JBS - Friboi. This company has been internationalized very fast in recent years and become a global leader in beef production, the second to the production of chicken meat and third largest producer of pork in the U.S. (JBS, 2010. The case is emblematic of JBS when analyzed under the concept of Porter's diamond applied to Brazil. This company gained scale and competitiveness with the access to natural resources of prodution (condition factor, but now it is necessary for maintenance its leading position, it requires a strategy grounded in innovation beyond just scale and operational excellence.

  8. Viga on öelda, et me ei vaja PRi / Roger Hayes, Alasdair Sutherland ; interv. Tiiu Värbu

    Hayes, Roger

    2001-01-01

    Eesti Suhtekorraldajate Liidu 5. aastapäeva seminaril osalevad Rahvusvahelise Kommunikatsiooni Instituudi direktor R. Hayes ja maailma ühe juhtiva suhtekorraldusfirma Manning, Selvage & Lee asepresident A. Sutherland

  9. A Multimethod Assessment of Juvenile Psychopathy: Comparing the Predictive Utility of the PCL:YV, YPI, and NEO PRI

    Cauffman, Elizabeth; Kimonis, Eva R.; Dmitrieva, Julia; Monahan, Kathryn C.

    2009-01-01

    The current study compares 3 distinct approaches for measuring juvenile psychopathy and their utility for predicting short- and long-term recidivism among a sample of 1,170 serious male juvenile offenders. The assessment approaches compared a clinical interview method (the Psychopathy Checklist: Youth Version [PCL:YV]; Forth, Kosson, & Hare,…

  10. Lead isotope ratios in tree bark pockets: An indicator of past air pollution in the Czech Republic

    Conkova, M. [Charles University, Faculty of Natural Sciences, Benatska 8, Prague 1 (Czech Republic)], E-mail: conkova@chmi.cz; Kubiznakova, J. [Czech Hydrometeorogical Institute, Na Sabatce 17, Prague 4 (Czech Republic)], E-mail: kubiznakova@chmi.cz

    2008-10-15

    Tree bark pockets were collected at four sites in the Czech Republic with differing levels of lead (Pb) pollution. The samples, spanning 1923-2005, were separated from beech (Fagus sylvatica) and spruce (Picea abies). Elevated Pb content (0.1-42.4 {mu}g g{sup -1}) reflected air pollution in the city of Prague. The lowest Pb content (0.3-2.6 {mu}g g{sup -1}) was found at the Kosetice EMEP 'background pollution' site. Changes in {sup 206}Pb/{sup 207}Pb and {sup 208}Pb/{sup 206}Pb isotope ratios were in agreement with operation times of the Czech main anthropogenic Pb sources. Shortly after the Second World War, the {sup 206}Pb/{sup 207}Pb isotope ratio in bark pockets decreased from 1.17 to 1.14 and the {sup 208}Pb/{sup 206}Pb isotope ratio increased from 2.12 to 2.16. Two dominant emission sources responsible for these changes, lignite and leaded petrol combustion, contributed to the shifts in Pb isotope ratios. Low-radiogenic petrol Pb ({sup 206}Pb/{sup 207}Pb of 1.11) lead to lower {sup 206}Pb/{sup 207}Pb in bark pockets over time. High-radiogenic lignite-derived Pb ({sup 206}Pb/{sup 207}Pb of 1.18 to 1.19) was detected in areas affected by coal combustion rather than by traffic.

  11. Worldwide lead-isotope ratio in bivalves and sediments

    Larsen, Martin Mørk; Jacobsen, Gitte; Strand, Jakob;

    The lead-isotope ratio have been used to assess and identify impact of leaded gasoline, coal combustion and  mineral activities[ref 1] due to the difference in 206Pb (~52%), 207Pb (~24%) and 208Pb (~23%) isotope ratios. The source of these differences is the decaying of the parent isotopes of 238U...... to 206Pb, 235U to 207Pb and 232Th to 208Pb. 204Pb is the only stable Pb isotope usually contributing 1% of the total Pb. Differences in 206Pb/207Pb ratio ranges from 1.06 to 1.10 in old Pb ores (e.g. the time of the roman empire), whereas recent mining from radiogenic (high U and Th contents) ores can...

  12. Distribuição e assinatura isotópica de Pb em sedimentos de fundo da Foz do Rio Guamá e da Baía do Guajará (Belém - Pará

    Suziane Nascimento Santos

    2012-01-01

    Full Text Available Lead analyses in bottom sediments from the hydrographic system of Belem (Para indicated low contents of this metal for the sediments from the Guama river, with no significant anthropogenic contribution. A concentration of 18.1 ± 1.5 mg kg-1 and 206Pb/207Pb isotopic signature of 1.196 ± 0.002 are assigned for Pb from natural sources. On the other hand, the significant increase of Pb contents in the sediments from the Guajará bay, together with the decrease of 206Pb/207Pb ratios (1.172 < 206Pb/207Pb < 1.188 point to an anthropogenic lead contribution, originated by the industrial and urban activities of the city of Belem.

  13. Neutron particle-hole electric dipole states in /sup 206/ /sup 207/ /sup 208/Pb. [16. 2 to 17. 8 MeV

    Dickey, P.A.

    1979-01-01

    Inelastic proton scattering on /sup 206/Pb, /sup 207/Pb, and /sup 208/Pb through isobaric analog resonances was used to study neutron particle-hole excitations with large ground-state gamma branches in these Pb isotopes. Relative (p,p') cross sections at 90/sup 0/ are extracted for structures selectively excited on the d/sub 5/2/, s/sub 1/2/, and d/sub 3/2/-g/sub 7/2/ resonances. Interpretation of excitations in /sup 206/Pb and /sup 207/Pb in terms of coupling to states in /sup 208/Pb is discussed. Branching ratios for 1/sup -/ states in /sup 208/Pb at 4.84, 5.29, 5.94, and 6.31 MeV and the 1/2/sup +/ state in /sup 207/Pb at 4.63 MeV are deduced. 15 figures, 4 tables.

  14. An odyssey of environmental pollution: the rise, fall and remobilization of industrial lead in Australia

    Taylor, M. P.; Kristensen, L.; Liqin, W.; Harvey, P. J.; Dong, C.; Rouillon, M.

    2015-12-01

    The use of lead in automobile gasoline resulted in more than 240,000 tonnes of lead being emitted to the Australian environment over its 70-year period of use starting in 1932. The consequences of the emissions and subsequent depositions have resulted in marked contamination of urban and peri-urban aerosols, soils, plants and humans. This paper charts these effects and examines the extent of recovery from one of the most pervasive and persistent environmental pollutants. Lead isotopic composition of Adelaide and Sydney aerosol filters show that air lead composition shifts from values that approximate Broken Hill type ores, the predominant lead source used in gasoline (1.04 206Pb/207Pb and 2.31 208Pb/207Pb), towards ratios that more closely match local uncontaminated soil and bedrock values (Adelaide ~1.19 206Pb/207Pb and ~2.50 208Pb/207Pb; Sydney ~1.15 206Pb/207Pb and 2.48 208Pb/207Pb). Proxy atmospheric measurements from historic wine, lichen and fungi samples extending over 120 years show how both concentration and composition values shifted in the middle to late 20th century to reflect petrol emissions and then recovered rapidly at the end of the century as leaded gasoline consumption declined. For example, lead in wine from South Australia fell from >100 μg/L in the 1960s and 1970s to arsenic, cadmium and nickel) are subject to frequent remobilization. Predicted increases in wildfires and the generation of lead, arsenic and cadmium toxic particulates warrants greater consideration of the risk for vulnerable populations and firefighters who are most exposed.

  15. Isotopic signatures for natural versus anthropogenic Pb in high-altitude Mt. Everest ice cores during the past 800 years

    Lee, Khanghyun; Hur, Soon Do [Korea Polar Research Institute, Songdo Techno Park, 7-50, Songdo-dong, Yeonsu-gu, Incheon 406-840 (Korea, Republic of); Hou, Shugui [State Key Laboratory of Cryospheric Science, Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Science, Lanzhou 730000 (China); School of Geographic and Oceanographic Sciences, Nanjing University, Nanjing 210093 (China); Burn-Nunes, Laurie J. [Department of Imaging and Applied Physics, Curtin University of Technology, GPO Box U1987, Perth, WA 6845 (Australia); Hong, Sungmin, E-mail: smhong@inha.ac.kr [Department of Ocean Sciences, Inha University, 253 Yonghyun-dong, Nam-gu, Incheon, 402-751 (Korea, Republic of); Barbante, Carlo [Department of Environmental Sciences, University Ca' Foscari of Venice, Dorsoduro 2137, 30 123 Venice (Italy); Institute for the Dynamics of Environmental Processes-CNR, University Ca' Foscari of Venice, Dorsoduro 2137, 30 123 Venice (Italy); Boutron, Claude F. [Laboratoire de Glaciologie et Geophysique de l' Environnement (UMR Universite Joseph Fourier/CNRS 5183 ), 54 rue Moliere, BP 96, 38402 Saint Martin d' Heres Cedex (France); Unite de Formation et de Recherche ' Physique, Ingenierie, Terre, Environnement, Mecanique' , Universite Joseph Fourier de Grenoble ( Institut Universitaire de France ), 715 rue de la Houille Blanche, BP 53, 38041 Grenoble Cedex 9 (France); Rosman, Kevin J.R. [Department of Imaging and Applied Physics, Curtin University of Technology, GPO Box U1987, Perth, WA 6845 (Australia)

    2011-12-15

    A long-term record, extending back 800 years (1205 to 2002 AD), of the Pb isotopic composition ({sup 206}Pb/{sup 207}Pb and {sup 208}Pb/{sup 207}Pb) as well as Pb concentrations from high altitude Mt. Everest ice cores has the potential to identify sources and source regions affecting natural and anthropogenic Pb deposition in central Asia. The results show that the regional natural background Pb isotope signature ({approx} 1.20 for {sup 206}Pb/{sup 207}Pb and {approx} 2.50 for {sup 208}Pb/{sup 207}Pb) in the central Himalayas was dominated by mineral dust over the last {approx} 750 years from 1205 to 1960s, mostly originating from local sources with occasional contributions of long-range transported dust probably from Sahara desert and northwestern India. Since the 1970s, the Pb isotope ratios are characterized by a continuous decline toward less radiogenic ratios with the least mean ratios of 1.178 for {sup 206}Pb/{sup 207}Pb and 2.471 for {sup 208}Pb/{sup 207}Pb in the period 1990-1996. The depression of the {sup 206}Pb/{sup 207}Pb and {sup 208}Pb/{sup 207}Pb values during the corresponding periods is most likely due to an increasing influence of less radiogenic Pb of anthropogenic origin mainly from leaded gasoline used in South Asia (India as well as possibly Bangladesh and Nepal). From 1997 to 2002, isotopic composition tends to show a shift to slightly more radiogenic signature. This is likely attributed to reducing Pb emissions from leaded gasoline in source regions, coinciding with the nationwide reduction of Pb in gasoline and subsequent phase-out of leaded gasoline in South Asia since 1997. An interesting feature is the relatively high levels of Pb concentrations and enrichment factors (EF) between 1997 and 2002. Although the reason for this feature remains uncertain, it would be probably linked with an increasing influence of anthropogenic Pb emitted from other sources such as fossil fuel combustion and non-ferrous metal production.

  16. On the determination of the pion effective mass in nuclei from pionic atoms

    Friedman, E.; Gal, A.

    1998-07-01

    The binding energies of the deeply bound 1s and 2p states in pionic atoms of 207Pb, recently established experimentally in the 208Pb(d,3He) reaction, have been used by several groups to derive the pion effective mass in nuclear matter. We show that these binding energies are fully consistent with `normal' pionic atoms and that the real part of the pion-nucleus potential at the center of 207Pb is 28+/-3 MeV and not 20 MeV as suggested previously.

  17. The Pb pollution fingerprint at Lochnagar: The historical record and current status of Pb isotopes

    Yang Handong [Environmental Change Research Centre, University College London, Pearson Building, Gower Street, London, WC1E 6BP (United Kingdom)]. E-mail: hyang@geog.ucl.ac.uk; Linge, Kathryn [NERC ICP Facility, School of Earth Sciences and Geography, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, KT1 2EE (United Kingdom); Rose, Neil [Environmental Change Research Centre, University College London, Pearson Building, Gower Street, London, WC1E 6BP (United Kingdom)

    2007-02-15

    Ratios of {sup 206}Pb/{sup 207}Pb in a Lochnagar sediment core slowly decline from c. 1.32 at 140 cm to c. 1.23 at 9 cm, and then rapidly decline to c. 1.15 at the surface. Ninety percent of the Pb in the surface sediments can be attributed to anthropogenic sources. The {sup 206}Pb/{sup 207}Pb ratio data imply that catchment peat surface contains a higher fraction of anthropogenic Pb than the sediment surface. The {sup 206}Pb/{sup 207}Pb ratios in the surface of the sediment core are consistent with ratios in trapped sediments collected annually between 1998 and 2003. However, there is no significant decline in these recent samples suggesting that the reduction in atmospheric Pb emissions has not yet been recorded by the sediments due to Pb inputs from the catchment. As catchment peats store about 840 kg previously deposited anthropogenic Pb since 1860, it is likely that catchment inputs will continue to affect future {sup 206}Pb/{sup 207}Pb ratios. - Pb previously deposited and stored in Lochnagar catchment has a major affect on contemporary Pb in the lake system.

  18. A century long sedimentary record of anthropogenic lead (Pb), Pb isotopes and other trace metals in Singapore.

    Chen, Mengli; Boyle, Edward A; Switzer, Adam D; Gouramanis, Chris

    2016-06-01

    Reconstructing the history of metal deposition in Singapore lake sediments contributes to understanding the anthropogenic and natural metal deposition in the data-sparse Southeast Asia. To this end, we present a sedimentary record of Pb, Pb isotopes and eleven other metals (Ag, As, Ba, Cd, Co, Cr, Cu, Ni, Tl, U and Zn) from a well-dated sediment core collected near the depocenter of MacRitchie Reservoir in central Singapore. Before the 1900s, the sedimentary Pb concentration was less than 2 mg/kg for both soil and sediment, with a corresponding (206)Pb/(207)Pb of ∼1.20. The Pb concentration increased to 55 mg/kg in the 1990s, and correspondingly the (206)Pb/(207)Pb decreased to less than 1.14. The (206)Pb/(207)Pb in the core top sediment is concordant with the (206)Pb/(207)Pb signal of aerosols in Singapore and other Southeast Asian cities, suggesting that Pb in the reservoir sediment was mainly from atmospheric deposition. Using the Pb concentration in the topmost layer of sediment, the estimated atmospheric Pb flux in Singapore today is ∼1.6 × 10(-2) g/m(2) yr. The concentrations of eleven other metals preserved in the sediment were also determined. A principal component analysis showed that most of the metals exhibit an increasing trend towards 1990s with a local concentration peak in the mid-20(th) century.

  19. Tracing changes in atmospheric sources of lead contamination using lead isotopic compositions in Australian red wine.

    Kristensen, Louise Jane; Taylor, Mark Patrick; Evans, Andrew James

    2016-07-01

    Air quality data detailing changes to atmospheric composition from Australia's leaded petrol consumption is spatially and temporally limited. In order to address this data gap, wine was investigated as a potential proxy for atmospheric lead conditions. Wine spanning sixty years was collected from two wine regions proximal to the South Australian capital city, Adelaide, and analysed for lead concentration and lead and strontium isotopic composition for source apportionment. Maximum wine lead concentrations (328 μg/L) occur prior to the lead-in-air monitoring in South Australia in the later 1970s. Wine lead concentrations mirror available lead-in-air measurements and show a declining trend reflecting parallel reductions in leaded petrol emissions. Lead from petrol dominated the lead in wine ((206)Pb/(207)Pb: 1.086; (208)Pb/(207)Pb: 2.360) until the introduction of unleaded petrol, which resulted in a shift in the wine lead isotopic composition closer to vineyard soil ((206)Pb/(207)Pb: 1.137; (208)Pb/(207)Pb: 2.421). Current mining activities or vinification processes appear to have no impact with recent wine samples containing less than 4 μg/L of lead. This study demonstrates wine can be used to chronicle changes in environmental lead emissions and is an effective proxy for atmospherically sourced depositions of lead in the absence of air quality data.

  20. Lead contamination in cocoa and cocoa products: isotopic evidence of global contamination.

    Rankin, Charley W; Nriagu, Jerome O; Aggarwal, Jugdeep K; Arowolo, Toyin A; Adebayo, Kola; Flegal, A Russell

    2005-10-01

    In this article we present lead concentrations and isotopic compositions from analyses of cocoa beans, their shells, and soils from six Nigerian cocoa farms, and analyses of manufactured cocoa and chocolate products. The average lead concentration of cocoa beans was cocoa and chocolate products were as high as 230 and 70 ng/g, respectively, which are consistent with market-basket surveys that have repeatedly listed lead concentrations in chocolate products among the highest reported for all foods. One source of contamination of the finished products is tentatively attributed to atmospheric emissions of leaded gasoline, which is still being used in Nigeria. Because of the high capacity of cocoa bean shells to adsorb lead, contamination from leaded gasoline emissions may occur during the fermentation and sun-drying of unshelled beans at cocoa farms. This mechanism is supported by similarities in lead isotopic compositions of cocoa bean shells from the different farms (206Pb/207Pb = 1.1548-1.1581; 208Pb/207Pb = 2.4344-2.4394) with those of finished cocoa products (206Pb/207Pb = 1.1475-1.1977; 208Pb/207Pb = 2.4234-2.4673). However, the much higher lead concentrations and larger variability in lead isotopic composition of finished cocoa products, which falls within the global range of industrial lead aerosols, indicate that most contamination occurs during shipping and/or processing of the cocoa beans and the manufacture of cocoa and chocolate products.

  1. Identifying sources of Pb pollution in urban soils by means of MC-ICP-MS and TOF-SIMS.

    Rodríguez-Seijo, Andrés; Arenas-Lago, Daniel; Andrade, María Luisa; Vega, Flora A

    2015-05-01

    Lead pollution was evaluated in 17 urban soils from parks and gardens in the city of Vigo (NW Spain). The Pb isotope ratios ((207)Pb/(206)Pb, (208)Pb/(204)Pb, (206)Pb/(204)Pb and (208)Pb/(206)Pb) were determined after being measured by MC-ICP-MS. The association of the isotopes ((204)Pb, (206)Pb, (207)Pb and (208)Pb) with the different components of the soil was studied using TOF-SIMS. The isotopic ranges obtained for the samples were between 1.116 and 1.203 ((206)Pb/(207)Pb), 2.044-2.143 ((208)Pb/(206)Pb), 37.206-38.608 ((208)Pb/(204)Pb), 15.5482-15.6569 ((207)Pb/(204)Pb) and 17.357-18.826 ((206)Pb/(204)Pb). The application of the three-end-member model indicates that the Pb derived from petrol is the main source of Pb in the soils (43.51% on average), followed by natural or geogenic Pb (39.12%) and industrial emissions (17.37%). The emissions derived from coal combustion do not appear to influence the content of Pb in the soil. TOF-SIMS images show that the Pb mainly interacts with organic matter. This technique contributes to the understanding of the association of anthropogenic Pb with the components of the soil, as well as the particle size of these associations, thus allowing the possible sources of Pb to be identified.

  2. Origin of lead in eight Central European peat bogs determined from isotope ratios, strengths, and operation times of regional pollution sources.

    Novák, Martin; Emmanuel, Simon; Vile, Melanie A; Erel, Yigal; Véron, Alain; Paces, Tomás; Wieder, R Kelman; Vanecek, Mirko; Stepánová, Markéta; Brízová, Eva; Hovorka, Jan

    2003-02-01

    Lead originating from coal burning, gasoline burning, and ore smelting was identified in 210Pb-dated profiles through eight peat bogs distributed over an area of 60,000 km2. The Sphagnum-dominated bogs were located mainly in mountainous regions of the Czech Republic bordering with Germany, Austria, and Poland. Basal peat 14C-dated at 11,000 years BP had a relatively high 206Pb/207Pb ratio (1.193). Peat deposited around 1800 AD had a lower 206Pb/207Pb ratio of 1.168-1.178, indicating that environmental lead in Central Europe had been largely affected by human activity (smelting) even before the beginning of the Industrial Revolution. Five of the sites exhibited a nearly constant 206Pb/207Pb ratio (1.175) throughout the 19th century, resembling the "anthropogenic baseline" described in Northern Europe (1.17). At all sites, the 206Pb/207Pb ratio of peat decreased at least until 1980; at four sites, a reversal to more radiogenic values (higher 206Pb/207Pb), typical of easing pollution, was observed in the following decade (1980-1990). A time series of annual outputs for 14 different mining districts dispersing lead into the environment has been constructed for the past 200 years. The production of Ag-Pb, coal, and leaded gasoline peaked in 1900, 1980, and 1980, respectively. In contrast to other European countries, no peak in annual Pb accumulation rates was found in 1900, the year of maximum ore smelting. The highest annual Pb accumulation rates in peat were consistent with the highest Pb emission rates from coal-fired power plants and traffic (1980). Although maximum coal and gasoline production coincided in time, their isotope ratios were unique. The mean measured 206Pb/207Pb ratios of local coal, ores, and gasoline were 1.19, 1.16, and 1.11, respectively. A considerable proportion of coal emissions, relative to gasoline emisions, was responsible for the higher 206Pb/207Pb ratios in the recent atmosphere (1.15) compared to Western Europe (1.10). As in West European

  3. A stable lead isotopic investigation of the use of sycamore tree rings as a historical biomonitor of environmental lead contamination.

    Patrick, Gavin J; Farmer, John G

    2006-06-01

    The validity of the use of sycamore (Acer pseudoplatanus) tree-rings for the reconstruction of atmospheric lead pollution histories was investigated. Tree cores spanning 1892-2003 were collected from several sycamores from the eastern shore of Loch Lomond, Scotland, an area with no local point sources of lead emission. The lead concentration and 206Pb/207Pb profiles of the Loch Lomond region cores were compared with corresponding data for the 210Pb-dated loch sediment, and also with data for moss of known age from a Scottish herbarium collection. Two of the seven sycamore cores showed the same lead concentration trend as the lead flux to the loch, the rest having no similarity to either each other or the loch sediment record. Two further sycamore cores showed some similarity in their temporal 206Pb/207Pb trends to those seen in the sediment and moss records, but only in part of their profiles, whilst the 206Pb/207Pb ratios of the other sycamore cores remained relatively unchanged for the majority of the time covered, or exhibited an opposite trend. The 206Pb/207Pb ratios of the tree cores were also mostly higher than those of the previously established records for any given time period. Tree cores covering 1878-2002 were also collected along transects from Wanlockhead and Tyndrum, two areas of former lead mining and smelting associated with distinct 206Pb/207Pb ratios of 1.170 and 1.144, respectively. The Wanlockhead tree cores exhibited a generally decreasing trend in lead concentration with both time and distance from the lead mine. The characteristic 206Pb/207Pb ratio of 1.170 was observed in samples close to the mine but a decrease in the influence of the mine-derived lead was observed in more distant samples. The tree sampled at Tyndrum showed elevated lead concentrations, which decreased with time, and a fairly constant 206Pb/207Pb ratio of 1.15 reflecting input from the mine, features not observed in any other trees along the transect. Overall the data

  4. Early atmospheric metal pollution provides evidence for Chalcolithic/Bronze Age mining and metallurgy in Southwestern Europe.

    Martínez Cortizas, Antonio; López-Merino, Lourdes; Bindler, Richard; Mighall, Tim; Kylander, Malin E

    2016-03-01

    Although archaeological research suggests that mining/metallurgy already started in the Chalcolithic (3rd millennium BC), the earliest atmospheric metal pollution in SW Europe has thus far been dated to ~3500-3200 cal.yr. BP in paleo-environmental archives. A low intensity, non-extensive mining/metallurgy and the lack of appropriately located archives may be responsible for this mismatch. We have analysed the older section (>2100 cal.yr. BP) of a peat record from La Molina (Asturias, Spain), a mire located in the proximity (35-100 km) of mines which were exploited in the Chalcolithic/Bronze Age, with the aim of assessing evidence of this early mining/metallurgy. Analyses included the determination of C as a proxy for organic matter content, lithogenic elements (Si, Al, Ti) as markers of mineral matter, and trace metals (Cr, Cu, Zn, Pb) and stable Pb isotopes as tracers of atmospheric metal pollution. From ~8000 to ~4980 cal.yr. BP the Pb composition is similar to that of the underlying sediments (Pb 15 ± 4 μg g(-1); (206)Pb/(207)Pb 1.204 ± 0.002). A sustained period of low (206)Pb/(207)Pb ratios occurred from ~4980 to ~2470 cal.yr. BP, which can be divided into four phases: Chalcolithic (~4980-3700 cal.yr. BP), (206)Pb/(207)Pb ratios decline to 1.175 and Pb/Al ratios increase; Early Bronze Age (~3700-3500 cal.yr. BP), (206)Pb/(207)Pb increase to 1.192 and metal/Al ratios remain stable; Late Bronze Age (~3500-2800 cal.yr. BP), (206)Pb/(207)Pb decline to their lowest values (1.167) while Pb/Al and Zn/Al increase; and Early Iron Age (~2800-2470 cal.yr. BP), (206)Pb/(207)Pb increase to 1.186, most metal/Al ratios decrease but Zn/Al shows a peak. At the beginning of the Late Iron Age, (206)Pb/(207)Pb ratios and metal enrichments show a rapid return to pre-anthropogenic values. These results provide evidence of regional/local atmospheric metal pollution triggered by the earliest phases of mining/metallurgy in the area, and reconcile paleo-environmental and

  5. Influences upon the lead isotopic composition of organic and mineral horizons in soil profiles from the National Soil Inventory of Scotland (2007–09)

    Farmer, John G., E-mail: J.G.Farmer@ed.ac.uk [School of GeoSciences, The University of Edinburgh, Crew Building, Alexander Crum Brown Road, Edinburgh, EH9 3FF Scotland (United Kingdom); Graham, Margaret C. [School of GeoSciences, The University of Edinburgh, Crew Building, Alexander Crum Brown Road, Edinburgh, EH9 3FF Scotland (United Kingdom); Eades, Lorna J. [School of Chemistry, The University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ Scotland (United Kingdom); Lilly, Allan; Bacon, Jeffrey R. [James Hutton Institute, Craigiebuckler, Aberdeen, AB15 8QH Scotland (United Kingdom)

    2016-02-15

    Some 644 individual soil horizons from 169 sites in Scotland were analyzed for Pb concentration and isotopic composition. There were three scenarios: (i) 36 sites where both top and bottom (i.e. lowest sampled) soil horizons were classified as organic in nature, (ii) 67 with an organic top but mineral bottom soil horizon, and (iii) 66 where both top and bottom soil horizons were mineral. Lead concentrations were greater in the top horizon relative to the bottom horizon in all but a few cases. The top horizon {sup 206}Pb/{sup 207}Pb ratio was lesser (outside analytical error) than the corresponding bottom horizon {sup 206}Pb/{sup 207}Pb ratio at (i) 64%, (ii) 94% and (iii) 73% of sites, and greater at only (i) 8%, (ii) 3% and (iii) 8% of sites. A plot of {sup 208}Pb/{sup 207}Pb vs. {sup 208}Pb/{sup 206}Pb ratios showed that the Pb in organic top (i, ii) and bottom (i) horizons was consistent with atmospherically deposited Pb of anthropogenic origin. The {sup 206}Pb/{sup 207}Pb ratio of the organic top horizon in (ii) was unrelated to the {sup 206}Pb/{sup 207}Pb ratio of the mineral bottom horizon as demonstrated by the geographical variation in the negative shift in the ratio, a result of differences in the mineral horizon values arising from the greater influence of radiogenic Pb in the north. In (iii), the lesser values of the {sup 206}Pb/{sup 207}Pb ratio for the mineral top horizon relative to the mineral bottom horizon were consistent with the presence of anthropogenic Pb, in addition to indigenous Pb, in the former. Mean anthropogenic Pb inventories of 1.5 and 4.5 g m{sup −2} were obtained for the northern and southern halves of Scotland, respectively, consistent with long-range atmospheric transport of anthropogenic Pb (mean {sup 206}Pb/{sup 207}Pb ratio ~ 1.16). For cultivated agricultural soils (Ap), this corresponded to about half of the total Pb inventory in the top 30 cm of the soil column. - Highlights: • Pb isotope ratios were determined for 644

  6. A lead isotopic study of the human bioaccessibility of lead in urban soils from Glasgow, Scotland

    Farmer, John G., E-mail: J.G.Farmer@ed.ac.uk [School of GeoSciences, University of Edinburgh, Edinburgh, EH9 3JN, Scotland (United Kingdom); Broadway, Andrew [School of GeoSciences, University of Edinburgh, Edinburgh, EH9 3JN, Scotland (United Kingdom); Cave, Mark R.; Wragg, Joanna [British Geological Survey, Keyworth, Nottingham NG12 5GG, England (United Kingdom); Fordyce, Fiona M. [British Geological Survey, Edinburgh, EH9 3LA, Scotland (United Kingdom); Graham, Margaret C.; Ngwenya, Bryne T. [School of GeoSciences, University of Edinburgh, Edinburgh, EH9 3JN, Scotland (United Kingdom); Bewley, Richard J.F. [URS Corporation Ltd, Manchester, M1 6HS, England (United Kingdom)

    2011-11-01

    The human bioaccessibility of lead (Pb) in Pb-contaminated soils from the Glasgow area was determined by the Unified Bioaccessibility Research Group of Europe (BARGE) Method (UBM), an in vitro physiologically based extraction scheme that mimics the chemical environment of the human gastrointestinal system and contains both stomach and intestine compartments. For 27 soils ranging in total Pb concentration from 126 to 2160 mg kg{sup -1} (median 539 mg kg{sup -1}), bioaccessibility as determined by the 'stomach' simulation (pH {approx} 1.5) was 46-1580 mg kg{sup -1}, equivalent to 23-77% (mean 52%) of soil total Pb concentration. The corresponding bioaccessibility data for the 'stomach + intestine' simulation (pH {approx} 6.3) were 6-623 mg kg{sup -1} and 2-42% (mean 22%) of soil Pb concentration. The soil {sup 206}Pb/{sup 207}Pb ratios ranged from 1.057 to 1.175. Three-isotope plots of {sup 208}Pb/{sup 206}Pb against {sup 206}Pb/{sup 207}Pb demonstrated that {sup 206}Pb/{sup 207}Pb ratios were intermediate between values for source end-member extremes of imported Australian Pb ore (1.04) - used in the manufacture of alkyl Pb compounds (1.06-1.10) formerly added to petrol - and indigenous Pb ores/coal (1.17-1.19). The {sup 206}Pb/{sup 207}Pb ratios of the UBM 'stomach' extracts were similar (< 0.01 difference) to those of the soil for 26 of the 27 samples (r = 0.993, p < 0.001) and lower in 24 of them. A slight preference for lower {sup 206}Pb/{sup 207}Pb ratio was discernible in the UBM. However, the source of Pb appeared to be less important in determining the extent of UBM-bioaccessible Pb than the overall soil total Pb concentration and the soil phases with which the Pb was associated. The significant phases identified in a subset of samples were carbonates, manganese oxides, iron-aluminium oxyhydroxides and clays. - Highlights: {yields} We determined the human bioaccessibility of Pb in urban soils by in vitro extraction. {yields} We

  7. [Reactivity of the physiological system of the connective tissue and immunoglobulin levels in divers of the Arctic Pri-Elbrus regions].

    Pavlovich, S I

    1991-01-01

    The functional state of the conjunctive tissue system in deep-divers has been evaluated by the Kavetsky-Leshchinsky method. The content of different classes of immunoglobulins in the mucosa of upper respiratory tracts has been studied by the fluorescent antibody method under conditions of the Arctic and highland. The long-term divings cause a decrease in the reactivity of a physiological system of conjunctive tissue and a shift in the parameters of the immunological organism status. These changes are found to be more pronounced in the deep divers with underwater work experience of more than 2,000 hours. The general immunological reactivity of the organism rises significantly after 2.5 months stay under conditions of the Elbrus (height--2100 m). These facts confirm an idea that favourable climatic factors of the highland are expedient to be used in the complex of rehabilitation measures for deep-divers.

  8. Vrednovanje Dobara pri Ocjeni Društvene Opravdanosti Investicionih Projekata / Evaluation of Goods in Assessment of Social Justification of Investment Projects

    Čoprka Miodrag

    2015-06-01

    Full Text Available The effects of an investment, depending on their type and size, may manifest differently on the economy, which is why it is necessary to examine various aspects of their evaluation. Starting from the fact that the market cannot always and at all times and circumstances properly evaluate all the goods and services from the society viewpoint, commercial justification may greatly differ from social justification. The main starting point in the process is the application of billing prices instead of market prices, i.e. consideration of opportunity costs and benefits of investment projects, as they are an integral part of the investment and are not applied in the best alternative use. Starting from the shortcomings of conventional financial analyses in the identification and evaluation of the effects of investment projects from a social aspect, it is necessary to promote increasingly popular and relevant approaches.

  9. Napoved razvoja hiperbilirubinemije pri donošenih novorojenčkih z neinvazivnimi metodami: Prediction of hyperbilirubinemia by noninvasive methods in full-term newborns:

    Bratanič, Borut; Pavlin, Tatjana; Gradecki, Mirjam; Furlan, Danijela; Žalec, Lidija; Oštir Mevželj, Darinka

    2013-01-01

    Introduction: The noninvasive screening methods for bilirubin determination were studied prospectively in a group of full-term healthy newborns with the aim of early prediction of pathological neonatal hyperbilirubinemia. Laboratory determination of bilirubin (Jendrassik- Grof (JG)) was compared to the noninvasive transcutaneous bilirubin (TcBIL) together with the determination of bilirubin in cord blood. Methods: The study group consisted of 284 full-term healthy consecutively born infants i...

  10. Razlike med spoloma pri nekaterih simptomih stresa ter intenzivnost doživljanja stresnih simptomov = Gender Differences in Some Stress Symptoms and Intensity of Experiencing Stress Symptoms

    Maja Meško

    2010-06-01

    Full Text Available The aim of this study was to identify the symptoms of stress and to establishgender differences in stress symptoms. We tried to find out ifthere are gender differences in the stress level at work, if there aregender differences in terms of stress symptoms frequency, and if thereare gender differences in terms of the intensity of experiencing stresssymptoms. In this study 85 randomly selected managers from Slovenecompanies participated. The results of the study have shown that thereare gender differences in terms of all the above mentioned factors,namely a statistically higher level of stress in women. In terms of stresssymptoms occurrence there are gender differences in some stress symptomsas well as in the intensity of experiencing stress symptoms.

  11. A Brief Discussion on Learning Style Construction in Pri-vate Higher Vocational Colleges%浅谈民办高职院校学风建设

    顾小移

    2014-01-01

    The quality of learning style construction in higher vo-cational colleges is not only directly related to the survival and development of private colleges, but also related to higher voca-tional college students' vital interests. Combined with the current situation of private higher vocational colleges at the present stage, in view of the problems in learning style construction, the writer proposed personal views, hoping to find out more effective meth-ods and measures for enhancing learning style construction.%高职院校的学风建设的好坏不仅直接关系着民办高校自身的生存和发展,更是一件关系着高职院校学生切身利益的大事情。本文结合现阶段民办高职院校的校情,针对学风建设中存在的问题,提出自己的观点和看法,以期找到加强学风建设更有效的方法和措施。

  12. Španjolski stručnjaci u Ciudad de Méxicu: priče o radu i tržištu rada

    Mendoza, Cristóbal; Ortiz Guitart, Anna

    2008-01-01

    U radu se istražuju radna iskustva skupine kvalificiranih španjolskih migranata u Ciudad de Méxicu uporabom kvalitativnih podataka. Među intervjuiranim Španjolcima identificiraju se dva tipa migranata: premještenici unutar TNC-a (transnacionalnih korporacija) i »migranti u sredini« (»oni koji nisu ni niskokvalificirani ni visokokvalificirani migranti«; Conradson i Latham, 2005a). To donekle dovodi u pitanje pretpostavke o kvalificiranim radnicima pokazujući mnogostruke radne putanje te iskust...

  13. Izboljšanje javne participacije pri prostorskem načrtovanju s pomočjo orodij spleta 2.0

    Igor Bizjak

    2012-01-01

    Full Text Available Javna participacija (ang. public participation je ena od oblik sodelovanja oziroma udeleževanja javnosti v postopkih prostorskega načrtovanja, ki omogoča posameznikom in skupinam, da izrazijo svoja mnenja, dajejo pobude in aktivno sodelujejo v teh postopkih. Ker je javna participacija pogosto omejena le na dajanje pripomb na že pripravljene prostorske načrte, predvidevamo, da bi jo lahko izboljšali s pomočjo informacijskih tehnologij, in sicer z uporabo novih spletnih orodij. Ena takih novosti je splet 2.0 (ang. web 2.0, koncept, ki je bil prvič predstavljen v letu 2004 in je v svetovni splet prinesel veliko orodij, ki jih koristno uporabljajo socialna omrežja in različne spletne storitve kot participatorne storitve z velikim številom uporabnikov. V članku so analizirane možnosti za medsebojno interakcijo javne participacije in spleta 2.0. Predstavljene so zahteve javne participacije v postopkih prostorskega načrtovanja, osnovna orodja spleta 2.0 in njegove zmožnosti glede omogočanja participacije v procesih prostorskega načrtovanja. V prispevku je ugotovljeno, da so orodja spleta 2.0 zelo uporabna za vključevanje javnosti v procese prostorskega načrtovanja, vendar zahtevajo veliko predpriprav in dobro tehnično osnovo.

  14. Zdravljenje s tamsulozinom pri kamnih v spodnji tretjini sečevoda: Treatment with tamsulosin in patients with distal ureteral calculi:

    Bizjak, Igor; Erklavec, Marko; Jagodič, Klemen; Korošec, Helena; Poteko, Sandi

    2008-01-01

    Background Symptomatic ureteral calculi are one of the most important issues in urologist emergency clinical settings. Spontaneous passage of distal ureteral calculi is usually achieved with good hydration and spasmoanalgetic drugs. á-blocker therapy may facilitate and accelerate the spontaneous passageof ureteral stones.Patients and In retrospective study we analyzed patients with renal colic admitted to our department in methods 2006. All of them had clinical examination, urine and blood an...

  15. Pričakovanja študentov glede na razlike v kakovosti storitev visokošolskih zavodov = Student Expectations of Higher Education Institution Services

    Marijana Sikošek

    2011-09-01

    Full Text Available New challenges witnessed also in Slovenian higher education requirea different approach towards understanding students and their expectations,as higher education becomes increasingly market-oriented.Since research on assessing student expectations is still rare, we havedecided to establish the expectations of students regarding their studiesat the University of Primorska. With the help of factor analysis, wehave determined that these expectations are related to the followingsix factors: relationship between teaching staff and students, faculty’sreputation, faculty’s environment, employment chances, academic excellence,and staff competence and expertise. Cluster analysis has revealeda difference between the expectations of students of professionalstudy programmes and students of academic study programmes.

  16. Sindrom pomanjkanja rastnega hormona pri odraslem - učinki nadomestnega zdravljenja: Syndrome of growth hormone deficiency in adults - effects of growth hormone replacement therapy:

    Pfeifer, Marija

    2001-01-01

    Background. After the cessation of longitudinal growth, growth hormone (GH) continues to subserve an important role in the regulation of body metabolism (stimulation of lipolysis and lipid oxidation, protein synthesis, insulin antagonism, and sodium and water retention) to optimise body composition and function. Most patients with hypopituitarism exhibit the syndrome of GH deficiency with a number of abnormal features which can be reversed with recombinant GH replacement therapy. Conclusions....

  17. Sodelovanje med zdravniki družinske medicine in specialisti psihiatri pri zdravljenju bolnikov z depresijo: Cooperation between family practitioners and psychiatrist in treating patients with depression:

    2011-01-01

    Background: By 2015, mental illness will become the greatest healthcare burdenin the world. Within the community, people with depression are most often treated by family doctors. Treatment for depression also includes psychiatric specialists, with varying cooperation between the primary care provider and the psychiatrist. This studyćs goal was to define cooperation between family doctors and psychiatric specialists when treating patients withdepression. Methods: In 2009 six focus groups were ...

  18. Správanie spotrebitel'a pri nákupe mliečnych produktov v maloobchodnom reťazci Tesco

    Moravčíková, Mária

    2015-01-01

    Consumer behavior buying milk product in string of retail Tesco. Bachelor thesis. Brno: Mendel University, 2015. The bachelor thesis is focused on in store comunication, consumer´s behaviour during shopping for milk and milk products in a Tesco shop. It is based on factors, which influence the consumers during purchasing, such as price, packaging and sales promotion. Furthermore it is dealing with visual merchandising and its influence on behaviour of consumers. Personal questionnaire, which...

  19. Pomen Centra šolskih in obšolskih dejavnosti (CŠOD pri pouku in terenskem delu geografije = Geography in Slovenian Field Study Centres

    Špela Odar

    1998-01-01

    Full Text Available The paper represents a program written for a "week in nature" for students of 5th, 6th and 7th primary school classes. Primary stress is given to the geographic themes, field work and theory, which are presented in a weekly course in one of 13 field studies centres in Slovenia.

  20. Metodología en operaciones de cementación priMaría y forzada utilizando nuevas tecnologías

    Campos, Isrrael; Armas, Diego; Guecara, Dani; Vargas, Javier; Tapia, Daniel

    2011-01-01

    El presente trabajo tiene como finalidad mostrar el diseño de la cementación del pozo arcángel 1D, En la primera parte planteamos brevemente, los diferentes tipos de Cementaciones que son aplicadas en la terminación de una fase en un pozo petrolero, así como, herramientas usadas, técnicas aplicadas y el uso de diferentes tipos de revestidores según la profundidad alcanzada en cada sección. Luego se presentara una descripción litológica de la zona en la cual se ha planificado la pe...

  1. Priones: una revisión de la enfermedad debilitante crónica y su posible control anti-priónico

    Ricardo Millán-González; Diego Soler-Tovar

    2014-01-01

    Los priones son proteínas del sistema nervioso, que cuando sufren cambios en su estructura protéica son responsables de generar enfermedades neurodegenerativas. Existe un gran interés por la alta estabilidad de estas moléculas. Estudios señalan que poseen una alta resistencia a ser inactivadas por varios agentes y que pueden persistir en la tierra años después de ser enterradas, generando una reserva de infectividad ambiental. En la medicina veterinaria existen varios animales domésticos susc...

  2. A method for formalizing the description of structures of porous mediums with their automatic analysis. Metod formalizovannogo opisaniya struktur poristykh sred pri ikh avtomaticheskom analize

    Kostenko, I.F.

    1983-01-01

    A set of parameters is examined which characterizes the properties of the sum of geometrical objects which make up the structure of the pore space of oil and gas collector rocks. The properties of the structures such as the mutual disposition of individual objects, the relationships of their dimensions, the complexity of form and the presence of the predominate orientation of the objects in the plane are also evaluated. The possibility of using the measured parameters for classifying structures is shown.

  3. Fault Analysis of PRI Interface Testing in GSM-R%GSM-R网络中PRI接口测试的故障分析

    苗丽丽; 蒋文怡; 贾怀义

    2005-01-01

    主要根据国际ITU-T标准及原国家邮电部技术规定,结合实验室监视到的PRI接口消息,深入分析了GSM-R网络中PRI接口测试时出现的各种异常现象,并给出改进建议.

  4. 氯化亚锡对胶乳标准胶PRI值的影响%Effect of stannous chloride on the PRI of standard rubber

    冯玉英

    2004-01-01

    介绍了氯化亚锡在不同季节对胶乳标准胶P0、PRI值的影响.结果表明,在3~4月它对胶乳标准胶的P0、PRI值影响不大;在5~10月的高温季节会造成胶乳标准胶P0、PRI值下降,甚至不达标;在生产上应严格控制氯化亚锡的使用.

  5. Parcels and Land Ownership, k7200pri - Parowan, Published in 2005, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Parcels and Land Ownership dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2005. It is described as...

  6. Identification of Radar PRI Modulation Style Characteristic Curve%雷达PRI调制样式特性曲线的识别

    吴振强; 张国毅; 常硕

    2015-01-01

    针对PRI调制样式特性曲线的特点提取了其最大值、等值比以及连续性参数作为特征参数,对PRI调制样式进行了分类,分析了非调制参数和调制参数对特性曲线和特征值的影响,利用支持向量机验证了存在脉冲丢失等噪声的情况下利用本研究提取的特征参数识别PRI调制样式的有效性.

  7. 基于PRI变换的未知雷达信号分选算法研究%Research on PRI Transform Algorithm of Unknown Radar Signal

    王宇

    2010-01-01

    针对未知雷达信号主处理中脉冲重复间隔的精确分选部分,介绍了PRI变换的脉冲重复间隔估计算法,提出针对固定重频、抖动重频和参差重频信号的PRI变换算法的仿真和改进方法.

  8. Portable infrared camera as a tool in topoclimatic research = Prenosna infrardeča kamera kot pripomoček pri topoklimatskem raziskovanju

    Miroslav Vysoudil

    2009-01-01

    Full Text Available The paper presents some possibilities of application of a portable infrared camera fortopoclimatic researches, especially for establishing the differences in temperatures of theso-called active surface layer. Demonstrated is the dependence of surface temperature onsurface characteristics, such as land use, morphological features and the time of the day. Theresults can be useful for establishing topoclimatic units with similar temperature regimes.

  9. Medosebni odnosi in vsebina dela kot dejavnika stresa pri srednjem managementu = Interpersonal Relationships and Work Content as Stress Factors among Middle Management

    Polona Kožuh

    2011-06-01

    Full Text Available In the modern society, where importance is placed on progress, newtechnologies and economic trends, there is a lack of awareness of thesignificance of good interpersonal relations and organizational culturewithin a company. They both contribute to the better functioningof employees as well as the entire organization. The purpose of thisstudy was to determine any possible differences between the stressorslinked to the relationships within an organization and those linked tothe work of middle management. The study included 58 middle managersworking in commercial activity in the Ljubljana region. The resultshave indicated that the amount of stressors related to the relationships,and stressors related to the managers’ work, that affect themiddle managers participating in the survey is on average the same.The results have therefore shown no statistically significant differencebetween the two forms of the studied stress factors.

  10. 一种改进型PRI变换雷达信号分选方法%De-interleaving of Radar Signal Based on Improved PRI Transform Algorithm

    田芬芳

    2010-01-01

    基于PRI分选有多种方法,其中PRI变换法对脉冲重复间隔有较高的估计精度,并克服了传统直方图统计法中的子谐波问题.文中在对PRI变换法进行深入研究的基础上,提出了一种改进的自适应PRI变换法,仿真结果验证了新算法的可靠性.

  11. Parcels and Land Ownership, k2400pri - Parowan, Published in 2005, 1:24000 (1in=2000ft) scale, Iron County.

    NSGIC GIS Inventory (aka Ramona) — This Parcels and Land Ownership dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2005. It is described as...

  12. Discussion of network construction based on ISDN PRI interface of Meridian%Meridian交换机使用ISDN PRI接口组网

    钟馥遥; 王金元

    2002-01-01

    使用PRI接口作局间中继进行组网,具有传统随路信令的数字中继所不可比拟的优越性和强大功能,该文简要介绍PRI接口的组网方式、网络功能及安装调试过程。

  13. An SNP site in pri-miR-124, a brain expressed miRNA gene, no contribution to mesial temporal lobe epilepsy in an Italian sample.

    Manna, Ida; Labate, Angelo; Borzì, Giuseppe; Mumoli, Laura; Cavalli, Salvatore Maria; Sturniolo, Miriam; Quattrone, Aldo; Gambardella, Antonio

    2016-08-01

    Mesial temporal lobe epilepsy (MTLE) is the most common type of refractory epilepsy and is usually associated with hippocampal sclerosis (Hs). The pathogenesis of MTLE involves many biological pathways, some of which seem to be regulated by microRNAs (miRNAs). Increasing evidence shows that single nucleotide polymorphisms (SNPs) or mutations in miRNAs sequence may affect the processing and function of miRNAs and participate in the occurrence of diseases. In this study, the effect of the SNP of one neuronal miRNA, miR-124, on susceptibility to MTLE was investigated using a case control study. To understand the role, a common C/G polymorphism designated rs531564 in the molecular mechanisms of MTLE, we sought to determine whether this genetic variant could influence susceptibility to disease in a cohort of 307 MTLE patients and 306 healthy controls, using TaqMan allelic discrimination assay, on an Applied Biosystems PCR platform. No statistically significant differences were found in the allele or genotype distributions of the miR-124 rs531564 polymorphism among MTLE patients and MTLE-free control subjects (p > 0.05). Our results demonstrate that this SNP has no major role in genetic susceptibility to MTLE, at least in the population studied here.

  14. Možnost ponovne uporabe regeneracijske odpadne vode pri ionskem izmenjevalcu za mehčanje vode v Pivovarni Laško

    Nemec, Nina

    2016-01-01

    Pivovarska industrija je en izmed velikih porabnikov vode, ki hkrati proizvaja tudi velike količine industrijske odpadne vode, ki obremenjujejo ekosistem. Teh težav se zavedajo tudi v podjetju Pivovarna Laško, ki kot IPPC (Integrated Pollution Prevention and Control – celovito preprečevanje in nadzor onesnaževanja) zavezanec nenehno optimizira uporabo vode v proizvodnem procesu, hkrati pa skrbi za ustrezno ravnanje z odpadnimi vodami. V magistrskem delu smo raziskali možnost ponovne uporabe r...

  15. 小学语文教学重在“悟”%Nothing is more Important than “Comprehension” in Pri-mary School Chinese Language Teaching

    2013-01-01

    Primary school Chinese language teaching shoulders the responsibility of cultivating students' reading habit, and a good reading habit can even influence the development of a per-son's personality. Making pupils love reading is the responsibility of every Chinese language teacher. Teachers should guide stu-dents and give them methods, so as to help them comprehend e-motions in reading.%  小学语文教学承担着培养学生良好阅读习惯的重任,而良好的阅读习惯甚至会关系到一个人健康人格的发展。让学生从小就爱上读书,每一位语文老师责无旁贷。老师要善于引导学生,给出方法,读中悟情、入境悟美、激疑悟新。

  16. Expected service quality measurement in tourism higher education: Merjenje pričakovane kakovosti storitev visokega izobraževanja v turizmu:

    2006-01-01

    This paper starts with background theory and the outlines the results of an exploratory study conducted on students at the Faculty of Tourism and Hospitality Management in Opatija (Croatia). The aims of the study are to: (1) provide a brief review of the existing tools for measuring students' experience, (2) assess students' expectations of service quality in tourism higher education, (3) test the reliability of a modified SERVQUAL scale, (5) establish the number of dimensions of service qual...

  17. Organochlorines and trace elements in avian pry of peregrine falcons in Colorado: Ten years after: First year interim report of a two year study

    US Fish and Wildlife Service, Department of the Interior — Bird species considered potential prey for peregrine falcons were collected at 10 sites in Colorado for analysis of organochlorine (OC) compounds and trace elements...

  18. 论小学语文对话教学的有效策略%On the Effective Strategies of Dialogue Teaching of Pri-mary School Chinese

    2013-01-01

      通过对对话教学概念的梳理,提出了对话教学是强调了师生之间的平等、民主、尊重、信任,体现了教学的主体性、创造性、人性化,以文本为参照来促进师生共同发展的一种现代教学活动;从三个方面探讨了小学语文对话教学的有效策略:构建以人为本的新型师生观,践行教师主导和学生主体有机结合的对话教学,倡导生成性、开放性的对话教学。%Through sorting concept of dialogue teaching, the new concept of dialogue teaching has been come up with in this re-search which emphasizes equal and democracy and respect and trust of teacher and student's relationship and which embodies main body and creativity and humanity of teaching and which is a modern teaching activity of improving teacher and student' co-development by means of Chinese textbook. The effective strategies of dialogue teaching of primary school Chinese has been discussed from three aspects of constructing new teacher and student' relationship based on human rights and practicing dialogue teaching of teacher and student' double main body in-quiring dialogue teaching of growing and opening.

  19. Pressure induced structural phase transition of PrX, PrY (X = S, Se, Te) chalcogenides and (Y = N, P, As) pnictides

    Varshney, Dinesh; Shriya, Swarna; Dube, A.; Varshney, Meenu

    2012-06-01

    Pressure induced structural aspects of NaCl-type (B1) to CsCl-type (B2) structure in Praseodymium pnictides and chalcogenides are presented. An effective interionic interaction potential with long range Coulomb, van der Waals interaction and the short-range repulsive interaction upto second-neighbor ions within the Hafemeister and Flygare approach with modified ionic charge is developed. Deduced results on volume discontinuity in pressure volume phase diagram identify the structural phase transition from B1 to B2 structure consistent with the known results.

  20. Association of Polymorphisms in three pri-miRNAs that Target Pepsinogen C with the Risk and Prognosis of Gastric Cancer

    Wu, Ye-feng; Xu, Qian; He, Cai-yun; Li, Ying; Liu, Jing-wei; Deng, Na; Sun, Li-ping; Yuan, Yuan

    2017-01-01

    We aimed to explore the associations of polymorphisms in three microRNAs (miRNAs) (let-7e rs8111742, miR-365b rs121224 and miR-4795 rs1002765) that target PGC with the risk and prognosis of gastric cancer/atrophic gastritis. Sequenom’s MassArray was used to genotype the miRNA polymorphisms in 724 gastric cancer cases, 862 atrophic gastritis cases and 862 controls in a Chinese population. We found that let-7e rs8111742 and miR-4795 rs1002765 were associated with the risk of gastric cancer in the H. pylori-positive subgroup. MiR-365b rs121224 was associated with the risk of intestinal-type gastric cancer in the alcohol consumption subgroup. Intestinal-type gastric cancer patients at Borrmann stages III-IV who carry the miR-365b rs121224 GG genotype had better prognosis compared with those who carry the CG or CC genotypes. MiR-365b rs121224 was associated with Lauren typing and TNM staging, in which the distribution of GG genotype carriers in intestinal-type gastric cancer and the TNM stage I-II subgroup was higher than that of CG or CC genotypes, which contrasted with the distribution in diffuse-type gastric cancer or TNM III-IV groups. These findings suggested that the polymorphisms in these miRNAs might be biomarkers for gastric cancer risk and prognosis, especially for populations infected with Helicobacter pylori or who consume alcohol. PMID:28067243

  1. Multiple genetic pathways for restarting DNA replication forks in Escherichia coli K-12.

    Sandler, S J

    2000-01-01

    In Escherichia coli, the primosome assembly proteins, PriA, PriB, PriC, DnaT, DnaC, DnaB, and DnaG, are thought to help to restart DNA replication forks at recombinational intermediates. Redundant functions between priB and priC and synthetic lethality between priA2::kan and rep3 mutations raise the possibility that there may be multiple pathways for restarting replication forks in vivo. Herein, it is shown that priA2::kan causes synthetic lethality when placed in combination with either Delt...

  2. PRI 8.1: CARNOT. Analysis and research community of the new orientations of the thermodynamics. Activity report june 2002/ june 2004; PRI 8.1: CARNOT. Communaute d'Analyse et de Recherche des Nouvelles Orientations de la Thermodynamique. Rapport d'activite juin 2002/ juin 2004

    NONE

    2004-07-01

    This progress report takes stock on the CARNOT project. This project aims to standardize the different approaches or identify the application fields of each thermodynamical methodology. The cycles analysis and more generally thermodynamical machines (design, energy efficiency, new energy utilization concepts). The environmental impact is also an important topic of the project. (A.L.B.)

  3. Pri svete vetra : Tjomnõi tunnel; Kogda-to na jarmarke; Daljoki, zabõtõi...; 'Hriplõi...'; Grustnaja pessenka; Bõla bõ metla...; Kannel; 'Pri svete vetra...'; Odnazhdõ; 'Kipariss...'; 'Na starom kostrisht'e...'; 'Vot spjashtshaja ja...'; 'Ser�

    Vaarandi, Debora, 1916-2007

    1996-01-01

    Orig.: Tume tunnel; Vana laadalugu; Kauge unustatud; "See on..."; Kurb lauluke; Luuata; Kandlemängija; "Tuule valgel..."; Üks; "Küpress..."; "Magan tormis mis mujal..."; "Ööliblikaid halle ja maokaid..."; "naised on need..."; "Krestomaatsed luuletused..."; Sisevaade

  4. Preliminary results of an extensive study of fragmentation measurements for medical and space applications

    Agodi, C; Calabretta, L; Cirrone, G A P C; Cuttone, G; De Napoli, M; Fiorini, F; Giacoppo, F; Mairani, A; Morone, M C; Patera, V; Raciti, G; Rapisarda, E; Ricciardi, V; Romano, F; Sala, P; Sciubba, A

    2010-01-01

    Here we report on preliminary results of an extensive study of fragmentation cross sections measurements useful for medical and space applications. In particular, we looked at the hadrontherapy and space radiation research. Indeed, the measure of fragmentation cross sections is an important information to estimate how this process modifies dose distributions and biological effectiveness, both inside human body and spacecraft. In this picture we started to measure the fragmentation of 12C beam accelerated by the Superconducting Cyclotron at 32 AMeV, 62 AMeV on 12C, 207Pb and 197Au at the INFN Laboratory Nazionali del Sud in Catania (Italy). Preliminary comparison between absolute cross-sections measured for the systems: 12C+207Pb at 32AMeV and for 12C+197Au at 62AMeV is performed.

  5. Lead contamination and transfer in urban environmental compartments analyzed by lead levels and isotopic compositions.

    Hu, Xin; Sun, Yuanyuan; Ding, Zhuhong; Zhang, Yun; Wu, Jichun; Lian, Hongzhen; Wang, Tijian

    2014-04-01

    Lead levels and isotopic compositions in atmospheric particles (TSP and PM2.5), street dust and surface soil collected from Nanjing, a mega city in China, were analyzed to investigate the contamination and the transfer of lead in urban environmental compartments. The lead contents in TSP and PM2.5 are significantly higher than them in the surface soil and street dust (p atmospheric particles. The plots of (206)Pb/(207)Pb vs.(208)Pb/(206)Pb and (206)Pb/(207)Pb vs. 1/Pb imply that the street dust and atmospheric particles (TSP and PM2.5) have very similar lead sources. Coal emissions and smelting activities may be the important lead sources for street dust and atmospheric particles (TSP and PM2.5), while the deposition of airborne lead is an important lead source for urban surface soil.

  6. Isotope abundance ratios of sr in wine provenance determinations, in a tree-root activity study, and of pb in a pollution study on tree-rings.

    Horn, P; Hölzl, S; Todt, W; Matthies, D

    1997-07-01

    Abstract In this contribution, the various and fundamentally different uses and applications of isotope signatures (of both heavy and light elements) are discussed. Examples are given for the successful use of (87)Sr/(86)Sr in uncovering fraud in wine trade. Also, in an experiment related to "Waldsterben", (87)Sr/(86)Sr analyses reveal rather unexpected responses of spruces and maple-trees to mechanical damage of their roots. In another study, from (206)Pb/(207)Pb (and (208)Pb/(207)Pb) analyses of tree growth-rings it is demonstrated that they do not accurately record lead burdens in the environment. This is contrary to current views on the subject of tree-rings as reliable banks of past heavy metal pollutions of the biosphere. Furthermore, new perspectives of applications of isotopes in biological tissues, including those of cosmogenic and nucleogenic origin will be shortly outlined.

  7. Metallic elements and isotope of Pb in wet precipitation in urban area, South America

    Migliavacca, Daniela Montanari; Teixeira, Elba Calesso; Gervasoni, Fernanda; Conceição, Rommulo Vieira; Raya Rodriguez, Maria Teresa

    2012-04-01

    The atmosphere of urban areas has been the subject of many studies to show the atmospheric pollution in large urban centers. By quantifying wet precipitation through the analysis of metallic elements (ICP/AES) and Pb isotopes, the wet precipitation of the Metropolitan Area of the Porto Alegre (MAPA), Brazil, was characterized. The samples were collected between July 2005 and December 2007. Zn, Fe and Mn showed the highest concentration in studied sites. Sapucaia do Sul showed the highest average for Zn, due to influence by the steel plant located near the sampling site. The contribution of anthropogenic emissions from vehicular activity and steel plants in wet precipitation and suspended particulate matter in the MAPA was identified by the isotopic signatures of 208Pb/207Pb and 206Pb/207Pb. Moreover the analyses of the metallic elements allowed also to identify the contribution of other anthropic sources, such as steel plants and oil refinery.

  8. Isotopic source signatures for atmospheric lead: the Southern Hemisphere

    Bollhöfer, A.; Rosman, K. J. R.

    2000-10-01

    Aerosols collected between 1994 and 1999 at more than 70 different sites affecting the Southern Hemisphere have been measured for their 206Pb/ 207Pb, 208Pb/ 207Pb and 206Pb/ 204Pb ratios and Pb concentrations. Lower ratios are found at the southern tips of Africa, Australia and South America probably due to the supply of alkyllead from a common supplier such as Associated Octel. The ratios increase in a northerly direction probably due to a changing market share in alkyllead or an increasing industrial Pb contribution. The geographical variations in isotopic signatures made it possible to broadly characterize the different regions that influence the Southern Hemisphere. Brazil and Argentina exhibited 206Pb/ 207Pb, 208Pb/ 207Pb and 206Pb/ 204Pb ratios in aerosols of 1.141-1.184, 2.416-2.442 and 17.77-18.57, respectively. Mexican aerosols had values of 1.188-1.197, 2.452-2.463 and 18.46-18.73. Aerosols sampled in Chile had low ratios in the South of 1.063-1.094, 2.337-2.373 and 16.46-17.13 which increased in a northerly direction. Emissions from South Africa were characterized by ratios 1.067-1.090, 2.340-2.358 and 16.53-16.99. In 1994-1995 Australia and New Zealand had ratios of 1.060-1.193, 2.324-2.445 and 16.08-18.54. In 1997 however, the range was narrower: 1.072-1.112, 2.342-2.398 and 16.55-17.36, respectively. These isotopic signatures are potentially useful for tracing sources of pollution and the movement of air-masses on a global scale.

  9. Pb-concentrations and Pb-isotope ratios in soils collected along an east-west transect across the United States

    Reimann, Clemens; Smith, David B.; Woodruff, Laurel G.; Flem, Belinda

    2011-01-01

    Analytical results for Pb-concentrations and isotopic ratios from ca. 150 samples of soil A horizon and ca. 145 samples of soil C horizon collected along a 4000-km east–west transect across the USA are presented. Lead concentrations along the transect show: (1) generally higher values in the soil A-horizon than the C-horizon (median 21 vs. 16.5 mg/kg), (2) an increase in the median value of the soil A-horizon for central to eastern USA (Missouri to Maryland) when compared to the western USA (California to Kansas) (median 26 vs. 20 mg/kg) and (3) a higher A/C ratio for the central to eastern USA (1.35 vs. 1.14). Lead isotopes show a distinct trend across the USA, with the highest 206Pb/207Pb ratios occurring in the centre (Missouri, median A-horizon: 1.245; C-horizon: 1.251) and the lowest at both coasts (e.g., California, median A-horizon: 1.195; C-horizon: 1.216). The soil C-horizon samples show generally higher 206Pb/207Pb ratios than the A-horizon (median C-horizon: 1.224; A-horizon: 1.219). The 206Pb/207Pb-isotope ratios in the soil A horizon show a correlation with the total feldspar content for the same 2500-km portion of the transect from east-central Colorado to the Atlantic coast that shows steadily increasing precipitation. No such correlation exists in the soil C horizon. The data demonstrate the importance of climate and weathering on both Pb-concentration and 206Pb/207Pb-isotope ratios in soil samples and natural shifts thereof in the soil profile during soil-forming processes.

  10. Study on High Intensity High Charge State Lead Ion Beam Production and Optimize%强流高电荷态Pb离子束的产生与优化研究

    何伟; 李锦钰; 赵环昱; 曹云; 孙良亭; 赵红卫; 张子民

    2005-01-01

    随着原子物理及表面物理研究的发展,高电荷态金属离子束的需求日益增多.近来,在中国科学院近代物理研究所14.5GHz LECR3离子源实验平台上,以炉子法产生的铅离子束作为研究对象,进行了一系列ECR离子源关键参数(如:磁场、炉子功率、掺气等)影响高电荷态铅离子束产额的实验研究,在此基础上,调整优化了LECR3离子源的状态参数,从而获得了强流高电荷态铅离子束18etA 207pb30+和6.7eμA207pb37+.%High charge state metal ion beam is quite effective and essential for new investigations on atomic physics and surface physics. Recently, The high intensity high charge state lead ion beams have been produced with IMP 14.5GHz LECR3, we investigated experimentally influences of some key parameters,such as magnetic field, electrical power on oven, gas mixing etc., on lead ion beam production. Through optimization of the ion source conditions, stable 207Pb30+ beam of 18eμA and 207Pb37+ beam of 6.7eμA have been obtained with oven method at 20kV extraction voltage.

  11. Three centuries of heavy metal pollution in Paris (France) recorded by urban speleothems.

    Pons-Branchu, Edwige; Ayrault, Sophie; Roy-Barman, Matthieu; Bordier, Louise; Borst, Wolfgang; Branchu, Philippe; Douville, Eric; Dumont, Emmanuel

    2015-06-15

    The first record of urban speleothems used to reconstruct the history of heavy metal pollution of shallow groundwaters is presented. Two speleothems grew during the last 300 years in an underground aqueduct in the north-eastern part of Paris. They display high Pb, Mn V, Cu, Cd and Al concentrations since 1900 due to the urbanization of the site which triggered anthropogenic contamination of the water feeding the speleothems. Surprisingly, these heavy metal concentrations are also high in the oldest part. This early pollution could come from the use of Parisian waste as fertilizers in the orchards and vineyards cultivated above the aqueduct before urbanization. Lead isotopes were measured in these carbonates as well as in lead artifacts from the 17th-18th centuries ((206)Pb/(207)Pb=1.180+/-0.003). The mean (206)Pb/(207)Pb ratio, for one of the speleothems is 1.181+/-0.003 unvarying with time. These lead signatures are close to those of coal and old lead from northern European mines, lower than the natural background signature. It confirms that the high metal concentrations found come from anthropogenic pollution. Conversely, the lead isotopic composition of the second speleothem presents two temporal trends: for the oldest levels, the mean value (1.183+/-0.003) is similar to the first speleothem. For the youngest part, a lower value (1.172+/-0.005) is recorded, evidencing the contribution of a new lead source at the beginning of the industrial revolution. Pb isotopes were also measured in recent samples from a nearby superficial site. The first sample is a recent (AD 1975+/-15 years) deposit ((206)Pb/(207)Pb=1.148+/-0.003), and the second, a thin subactual layer ((206)Pb/(207)Pb=1.181+/-0.002). These data are compatible with the adding of anthropogenic sources (leaded gasoline and industrial lead from Rio Tinto ore).

  12. Lead isotope exchange between dissolved and fluvial particulate matter: a laboratory study from the Johor River estuary

    Chen, Mengli; Boyle, Edward A.; Lee, Jong-Mi; Nurhati, Intan; Zurbrick, Cheryl; Switzer, Adam D.; Carrasco, Gonzalo

    2016-11-01

    Atmospheric aerosols are the dominant source of Pb to the modern marine environment, and as a result, in most regions of the ocean the Pb isotopic composition of dissolved Pb in the surface ocean (and in corals) matches that of the regional aerosols. In the Singapore Strait, however, there is a large offset between seawater dissolved and coral Pb isotopes and that of the regional aerosols. We propose that this difference results from isotope exchange between dissolved Pb supplied by anthropogenic aerosol deposition and adsorbed natural crustal Pb on weathered particles delivered to the ocean by coastal rivers. To investigate this issue, Pb isotope exchange was assessed through a closed-system exchange experiment using estuarine waters collected at the Johor River mouth (which discharges to the Singapore Strait). During the experiment, a known amount of dissolved Pb with the isotopic composition of NBS-981 (206Pb/207Pb = 1.093) was spiked into the unfiltered Johor water (dissolved and particulate 206Pb/207Pb = 1.199) and the changing isotopic composition of the dissolved Pb was monitored. The mixing ratio of the estuarine and spike Pb should have produced a dissolved 206Pb/207Pb isotopic composition of 1.161, but within a week, the 206Pb/207Pb in the water increased to 1.190 and continued to increase to 1.197 during the next two months without significant changes of the dissolved Pb concentration. The kinetics of isotope exchange was assessed using a simple Kd model, which assumes multiple sub-reservoirs within the particulate matter with different exchange rate constants. The Kd model reproduced 56% of the observed Pb isotope variance. Both the closed-system experiment and field measurements imply that isotope exchange can be an important mechanism for controlling Pb and Pb isotopes in coastal waters. A similar process may occur for other trace elements. This article is part of the themed issue 'Biological and climatic impacts of ocean trace element chemistry'.

  13. The lead (Pb) isotope signature, behaviour and fate of traffic-related lead pollution in roadside soils in The Netherlands.

    Walraven, N; van Os, B J H; Klaver, G Th; Middelburg, J J; Davies, G R

    2014-02-15

    In this study the origin, behaviour and fate of anthropogenic Pb in sandy roadside soils were assessed by measuring soil characteristics, Pb isotope composition and content. In 1991 and 2003 samples were taken at different depth intervals at approximately 8 and 75 m from two highways in The Netherlands. The Pb isotope composition of the litter layer ((206)Pb/(207)Pb=1.12-1.14) differs from the deeper soil samples ((206)Pb/(207)Pb=1.20-1.21). Based on a mixing model it is concluded that the samples contain two Pb sources: natural Pb and anthropogenic Pb, the latter mainly derived from gasoline. (206)Pb/(207)Pb ratios demonstrate that the roadside soils were polluted to a depth of ~15 cm. Within this depth interval, anthropogenic Pb content is associated with organic matter. Although Pb pollution only reached a depth of ~15 cm, this does not mean that the topsoils retain all anthropogenic Pb. Due to the low pH and negligible binding capacity of soils at depths >15 cm, anthropogenic Pb migrated towards groundwater after reaching depths of >15 cm. The Pb isotope composition of the groundwater ((206)Pb/(207)Pb=1.135-1.185) establishes that groundwater is polluted with anthropogenic Pb. The contribution of anthropogenic Pb to the groundwater varies between ~30 and 100%. Based on the difference in soil Pb content and Pb isotope compositions over a period of 12 years, downward Pb migration is calculated to vary from 72 ± 95 to 324 ± 279 mg m(-2)y(-1). Assuming that the downward Pb flux is constant over time, it is calculated that 35-90% of the atmospherically delivered Pb has migrated to the groundwater.

  14. Lead and stable lead isotope ratios in soil, earthworms, and bones of American woodcock (Scolopax minor) from eastern Canada.

    Scheuhammer, Anton M; Bond, Della E; Burgess, Neil M; Rodrigue, Jean

    2003-11-01

    A study to discriminate among different possible sources of elevated Pb exposure for American woodcock (Scolopax minor) in eastern Canada is described. Undamaged wing bones excised from young-of-the-year woodcock collected from several locations in southern Ontario, southern Quebec, New Brunswick, and Nova Scotia, Canada, along with soil and earthworm (Aporrectodea tuberculata and Lumbricus rubellus) samples from the same sites, were analyzed for total Pb, and stable Pb isotopes. Ignoring six soil samples with high (> 60 microg/g) Pb concentration from the vicinity of Montreal (QC, Canada), the mean soil-Pb concentration for all sites combined was 19 microg/g (dry wt; n = 64), with a mean 206Pb:207Pb ratio of 1.19, values typical for uncontaminated rural soils in eastern North America. In earthworms, Pb concentrations ranged from 2.4 to 865 (microg/g [dry wt], mean = 24 microg/g). Concentrations of Pb in worms and soils were positively correlated (r = 0.71; p 20 microg/g) had 206Pb:207Pb ratios substantially different from worms and soils sampled from the same areas, even though woodcock feed extensively on soil invertebrates, especially earthworms. The range of 206Pb:207Pb ratios in wing bones of woodcock with elevated Pb exposure was not consistent with exposure to environmental Pb from past gasoline combustion nor Precambrian mining wastes but was consistent with ingestion of spent Pb shotgun pellets.

  15. Lead isotope ratios as a tracer for lead contamination sources: A lake Andong case study

    Kim Y. H

    2013-04-01

    Full Text Available The objective of this study was to evaluate stable Pb isotope signatures as a tracer for Pb contamination in Lake Andong. For Pb isotope analysis, we collected water and sediment from Lake Andong, particles in the air, soils, and stream water, mine tailings, sludge and wastewater from zinc smelting around lake Andong watershed. The results showed that Pb isotope ratios (206Pb/204Pb, 207Pb/204Pb, and 208Pb/204Pb for zinc concentrate were 18.809 ± 0.322, 15.650 ± 0.062, and 38.728 ± 0.421, respectively. In wastewater, isotopic ratio values (206Pb/204Pb, 207Pb/204Pb, and 208Pb/204Pb were 17.363 ± 0.133, 15.550 ± 0.025, and 37.217 ± 0.092, respectively. Additionally, isotopic ratio values (206Pb/204Pb, 207Pb/204Pb, and 208Pb/204Pb for sludge were 17.515 ± 0.155, 15.537 ± 0.018, and 37.357 ± 0.173, respectively. These values were similar to those in zinc and lead concentrate originated from Canada and South America. In contrast, Pb isotope ratios of soil, tailings and sediment from Lake Andong were similar to those of Korean ore. Atmospheric particles showed different patterns of Pb isotope ratios from sediments, soils, and zinc smelting and this needs further investigation in order to identify atmospheric Pb sources.

  16. A lead isotopic assessment of tree bark as a biomonitor of contemporary atmospheric lead

    Patrick, Gavin J. [School of GeoSciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JN, Scotland (United Kingdom); Farmer, John G. [School of GeoSciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JN, Scotland (United Kingdom)], E-mail: J.G.Farmer@ed.ac.uk

    2007-12-15

    The outermost bark layer of trees, predominantly Scots pine (Pinus sylvestris), was sampled at 82 non-urban locations from six arbitrarily designated areas (Northwest, Northeast, Central Highlands, Central and East, Central and Southwest, Southeast), throughout Scotland during 2002-2003 and analysed for lead concentration and stable lead isotopes by flame atomic absorption spectrometry (AAS) and inductively coupled plasma-mass spectrometry (ICP-MS), respectively. The mean lead concentration and mean {sup 206}Pb/{sup 207}Pb ratio ({+-} 1 standard deviation, SD) for bark samples from the areas were as follows: Northwest (8.0 mg kg{sup -1}, 1.121 {+-} 0.014, n = 17), Northeast (8.9 mg kg{sup -1}, 1.117 {+-} 0.012, n = 12), Central Highlands (11.3 mg kg{sup -1}, 1.130 {+-} 0.010, n = 11), Central and East (35.3 mg kg{sup -1}, 1.120 {+-} 0.007, n = 10), Central and Southwest (20.6 mg kg{sup -1}, 1.125 {+-} 0.018, n = 22) and Southeast (34.4 mg kg{sup -1}, 1.120 {+-} 0.005, n = 10), with an overall mean lead concentration of 18.5 mg kg{sup -1} (range 0.6-146 mg kg{sup -1}, median 8.4 mg kg{sup -1}) and an overall mean {sup 206}Pb/{sup 207}Pb ratio of 1.122 {+-} 0.014 (range 1.089-1.168, median 1.122). The overall mean {sup 206}Pb/{sup 207}Pb ratio for bark was therefore significantly lower (p < 0.01, t test) than the mean atmospheric {sup 206}Pb/{sup 207}Pb ratio of 1.154 {+-} 0.006 (range 1.144-1.167, n = 50) and 1.154 {+-} 0.010 (range 1.134-1.171, n = 26) as determined in rainwater collected routinely at Glensaugh, Central Highlands, during 2002 and 2003, respectively. The bark {sup 206}Pb/{sup 207}Pb values, 90% of which lay between 1.10 and 1.14, were more akin to those recorded for the atmosphere (via rainwater, atmospheric particulates, moss, etc.) at various locations throughout Scotland during the 1990s, a decade over which the use of leaded petrol (mean {sup 206}Pb/{sup 207}Pb ratio = 1.076 {+-} 0.011) declined markedly before its complete withdrawal in 2000

  17. Effectiveness of leaded petrol phase-out in Tianjin, China based on the aerosol lead concentration and isotope abundance ratio

    Wang Wan [Chinese Research Academy of Environmental Sciences, Beijing 100012 (China); Liu Xiande [Chinese Research Academy of Environmental Sciences, Beijing 100012 (China)]. E-mail: liuxdlxd@hotmail.com; Zhao Liwei [Tianjin Environmental Monitoring Center, Tianjin, 300190 (China); Guo, Dongfa [Beijing Research Institute of Uranium Geology, Beijing 100029 (China); Tian Xiaodan [University of Antwerp, UA, B-2610 Wilrijk-Antwerpen (Belgium); Adams, Freddy [University of Antwerp, UA, B-2610 Wilrijk-Antwerpen (Belgium)

    2006-07-01

    The phase-out of leaded petrol has been a measure widely used to reduce atmospheric lead pollution. Since the 1980s, China began to promote unleaded petrol. In order to assess the effectiveness of the measure an isotope fingerprint technique was applied for aerosol samples in the city of Tianjin. After dilute acid leaching, the lead concentration and isotope abundance ratios were determined for 123 samples collected in Tianjin during eight years (1994-2001). The {sup 206}Pb / {sup 207}Pb ratio was lower in summer, when coal combustion emission was low and vehicle exhaust became more important, indicating that the {sup 206}Pb / {sup 207}Pb ratio of leaded petrol in Tianjin is lower than that of aerosol samples. The {sup 206}Pb / {sup 207}Pb ratio gradually increased from 1994 to 2001, a trend that suggests that the contribution from vehicle exhaust was diminishing. Overall, the measurements matched well with national statistical data of leaded and unleaded petrol production. After the nationwide switch to unleaded gasoline, comprehensive control measures are urgently needed to reduce air lead pollution in China, as aerosol lead reduced slightly but remains at a relatively high level.

  18. Effectiveness of leaded petrol phase-out in Tianjin, China based on the aerosol lead concentration and isotope abundance ratio

    Wang, Wan; Liu, Xiande [Chinese Research Academy of Environmental Sciences, Beijing 100012 (China); Zhao, Liwei [Tianjin Environmental Monitoring Center, Tianjin, 300190 (China); Guo, Dongfa [Beijing Research Institute of Uranium Geology, Beijing 100029 (China); Tian, Xiaodan; Adams, Freddy [University of Antwerp, UA, B-2610 Wilrijk-Antwerpen (Belgium)

    2006-07-01

    The phase-out of leaded petrol has been a measure widely used to reduce atmospheric lead pollution. Since the 1980s, China began to promote unleaded petrol. In order to assess the effectiveness of the measure an isotope fingerprint technique was applied for aerosol samples in the city of Tianjin. After dilute acid leaching, the lead concentration and isotope abundance ratios were determined for 123 samples collected in Tianjin during eight years (1994-2001). The {sup 206}Pb/{sup 207}Pb ratio was lower in summer, when coal combustion emission was low and vehicle exhaust became more important, indicating that the {sup 206}Pb/{sup 207}Pb ratio of leaded petrol in Tianjin is lower than that of aerosol samples. The {sup 206}Pb/{sup 207}Pb ratio gradually increased from 1994 to 2001, a trend that suggests that the contribution from vehicle exhaust was diminishing. Overall, the measurements matched well with national statistical data of leaded and unleaded petrol production. After the nationwide switch to unleaded gasoline, comprehensive control measures are urgently needed to reduce air lead pollution in China, as aerosol lead reduced slightly but remains at a relatively high level. (author)

  19. Isotopic characterisation of lead in contaminated soils from the vicinity of a non-ferrous metal smelter near Plovdiv, Bulgaria

    Bacon, Jeffrey R. [Macaulay Institute, Craigiebuckler, Aberdeen AB15 8QH (United Kingdom)]. E-mail: j.bacon@macaulay.ac.uk; Dinev, Nikolai S. [N Poushkarov Institute of Soil Science and Agroecology, Sofia (Bulgaria)

    2005-03-01

    Soil samples from the vicinity of a non-ferrous metal smelter near Plovdiv, Bulgaria contained very high concentrations of cadmium, lead and zinc (up to 140, 4900 and 5900 mg kg{sup -1}, respectively). A roadside soil in a relatively uncontaminated area also contained high concentrations of the same metals (24, 1550 and 1870 mg kg{sup -1}, respectively) indicating that the transport of ores could be a source of contamination. Even though the lead isotope ratios in all the samples fell within a very narrow range (for example, 1.186-1.195 for {sup 206}Pb/{sup 207}Pb), the samples could be differentiated into three distinct groups: ores ({sup 206}Pb/{sup 207}Pb and {sup 208}Pb/{sup 207}Pb ratios of 1.1874-1.1884 and 2.4755-2.4807, respectively), current deposition (1.1864 and 2.4704-2.4711, respectively) and local background (1.1927-1.1951 and 2.4772-2.4809, respectively). Although most of the current deposition has its origin in the ores used at the smelter, up to 12% could be from other sources such as petrol lead. - Although soils in the vicinity of a non-ferrous metal smelter near Plovdiv, Bulgaria, have become highly contaminated with the ores used, lead isotope analysis has revealed that up to 12% of current deposition could be from other sources such as petrol lead.

  20. Transport and selective uptake of radium into natural clay minerals

    Hidaka, Hiroshi; Horie, Kenji; Gauthier-Lafaye, Françoise

    2007-12-01

    Understanding of the environmental behavior of Ra is important from the viewpoint of the long-termed repository safety of radioactive waste, but investigation of Ra behavior in natural environment is difficult to detect. We found isotopic evidence of Ra transportation and its selective uptake into clay minerals from Pb isotopic analyses. Illite grains found in calcite veins included in sandstone near the Oklo uranium deposit, Republic of Gabon, show extremely low 207Pb/ 206Pb (˜ 0.0158) isotopic ratios. Although the Pb isotopic ratios of calcite and quartz coexisting with illite indicate the formation age of each component, those of illite do not. In addition, illite grains having low 207Pb/ 206Pb isotopic ratios contain a strongly large amount of Ba (1230 to 6010 ppm) in contrast with low contents of Ba in calcite and quartz (< 0.26 ppm). Considering the chemical similarity between Ba and Ra, the 207Pb/ 206Pb isotopic data suggest an excess of 206Pb due to selective adsorption of 226Ra (and also Ba) into illite grains. This is a very rare example to show evidence of the selective adsorption behavior of Ra from the isotopic excesses of 206Pb, although the adsorption ability of Ra itself in nature was largely reported.

  1. Pb-Pb zircon ages of the Porto Nacional high-grade metamorphic terrain, northern portion of the Goias Massif, central Brazil

    Gorayeb, Paulo Sergio de Sousa; Moura, Candido Augusto Veloso [Para Univ., Belem, PA (Brazil). Centro de Geociencias]. E-mail: gorayebp@ufpa.br; c_moura@ufpa.br; Barros, Gisele Ribeiro de [Para Univ., Belem, PA (Brazil). Programa Institucional de Bolsas de Iniciacao Cientifica (PIBIC)]. E-mail: agbarros@amazon.com.br

    2000-03-01

    Single zircon Pb-evaporation ages were determined for a mafic granulite, two enderbites and a kinzigite of the Porto Nacional High-Grade Metamorphic Terrain (PNHGT) in the Goias massif. Zircons from mafic granulites and one of the enderbites of yielded average {sup 207} Pb/{sup 206} Pb ages of 2125{+-}3 Ma and 2153{+-}1 Ma, respectively, being interpreted as minimum ages of the igneous protoliths. The other enderbite, whose zircons presented round terminations, yielded an average {sup 207} Pb/{sup 206} Pb age of 2097 {+-} 2 Ma. Zircons from the kinzigite, displaying cores and rims overgrowth, presented {sup 207} Pb/{sup 206} Pb ages ranging between 2027 and 2115 Ma. However, a very homogeneous zircon crystal without overgrowth yielded age of 2100 {+-} 2 Ma, with a distinctive low Th/U value (0.02). This zircon is interpreted as a metamorphic crystal and its age probably sets the age of the granulite facies metamorphism, indicating that the PNHGT is a result of the Transamazonian thermotectonic event. (author)

  2. Investigation on primary and secondary processes in Nasirabad manganese deposit, south of Neyriz: using mineralogy and Pb isotope geochemistry

    Ali Reza Zarasvandi

    2013-04-01

    Full Text Available The Nasirabad manganese deposit is located 5 km south of Nasirabad, 8 km SW of Neyriz in the Fars province. Structurally, the area is placed in the southeastern part of Zagros thrust belt. In this area, the manganese mineralization occurred as ore layers and nodules, interlayered with Pichakun radiolarite chert deposits. In this study, mineralogy and geochemistry of uranium, thorium and lead isotopes were used to investigate the primary and secondary processes. In this way, in addition to petrographic and XRD studies, ICP-MS analysis was carried out in order to measure the U, Th and Pb isotopes. The strong fractionation of Fe and Mn phases and also the absence of Fe-bearing minerals in the XRD results, presence of syngenetic todorokite and quartz crystals, high U/Th ratios in some samples and Th versus U diagrams, all indicate entrance of Mn-bearing hydrothermal fluids into the sedimentary basin of the Nasirabad manganese deposit. The pyrolusites in radiolarites tests as replacement textures, host rock space filling and fracture filling pyrolusites, indicates the influence of secondary exogenic processes on primary hydrothermal mineralization. Non-homogenous 206Pb/Pb204, 207Pb/Pb204 and 208Pb/Pb204 values show non-steady hydrothermal processes in the sedimentary basin and indicate mixing of hydrothermal lead isotopes with another secondary source. Strong positive correlation between absolute values of radiogenic lead isotopes and insoluble High Field Strength Elements (HFSE such as 207Pb vs Nb (r=0.81, 207Pb vs TiO2 (r=0.93, 207Pb vs Th (r=0.79 and strong correlation between these elements and some mafic components like 208Pb vs Fe2O3 (r=0.94 and Th vs MgO (r=0.86 represent entrance of radiogenic lead with mafic detrital materials into the sedimentary basin. Similar linear trend among 206Pb/Pb204 vs 208Pb/Pb204 and 207Pb/Pb204 ratios in nodules and manganese layers show the same geochemical condition in Mn-nodules and layers formation and

  3. Plumbotectonic aspects of polymetallic vein mineralization in Paleozoic sediments and Proterozoic basement of Moravia (Czech Republic)

    Slobodník, Marek; Jacher-Śliwczyńska, Katarzyna; Taylor, Matthew C.; Schneider, Jens; Dolníček, Zdeněk

    2008-02-01

    A regional isotopic study of Pb and S in hydrothermal galenas and U-Pb and S in potential source rocks was carried out for part of Moravia, Czech Republic. Two major generations of veins, (syn-) Variscan and post-Variscan, are defined based on the Pb-isotope system together with structural constraints (local structures and regional trends). The Pb-isotopic compositions of galena plot in two distinct populations with outliers in 206Pb/204Pb-207Pb/204Pb space. Galena from veins hosted in greywackes provides a cluster with the lowest Pb-Pb ratios: 206Pb/204Pb = 18.15-18.27, 207Pb/204Pb = 15.59-15.61, 208Pb/204Pb = 38.11-38.23. Those hosted in both limestones and greywackes provide the second cluster: 206Pb/204Pb = 18.37-18.44, 207Pb/204Pb = 15.60-15.63, 208Pb/204Pb = 38.14-38.32. These clusters suggest model Pb ages as Early Carboniferous and Triassic-Jurassic, the latter associated with MVT-like deposits. Two samples from veins hosted in Proterozoic rocks lie outside the two clusters: in metagranitoid (206Pb/204Pb = 18.55, 207Pb/204Pb = 15.64, 208Pb/204Pb = 38.29) and in orthogneiss (206Pb/204Pb = 18.79, 207Pb/204Pb = 15.73, 208Pb/204Pb = 38.54). The results from these two samples suggest an interaction of mineralizing fluids with the radiogenic Pb-rich source (basement?). The values of δ34S suggest the Paleozoic host rocks (mostly -6.7 to +5.2‰ CDT) as the source of S for hydrothermal sulfides (mostly -4.8 to +2.5‰ CDT). U-Pb data and Pb isotope evolutionary curves indicate that Late Devonian and Early Carboniferous sediments, especially siliciclastics, are the general dominant contributor of Pb for galena mineralization developed in sedimentary rocks. Plumbotectonic mixing occurred, it is deduced, only between the lower and the upper crust (the latter involving Proterozoic basement containing heterogeneous radiogenic Pb), without any significant input from the mantle. It is concluded that in the Moravo-Silesian and Rhenohercynian zones (including proximal

  4. Isotope exchange between natural and anthropogenic Pb in the coastal waters of Singapore: exchange experiment, Kd model, and implications for the interpretation of coastal 210Pb data

    Boyle, E. A.; Chen, M.; Zurbrick, C.; Carrasco, G. G.

    2015-12-01

    Observations from annually-banded corals and seawater samples show that marine lead (Pb) in the coastal waters of Singapore has an isotopic composition that does not match that of the anthropogenic aerosols in this region, unlike what is seen in most parts of the open ocean. The 206Pb/207Pb composition of Singaporean marine Pb is 1.18-1.20 whereas the local aerosols are 1.14-1.16. In order to explore this discrepancy further, we collected a large volume water from the Johor River estuary (flowing from Malaysia to the northern border of Singapore), added a distinct isotope spike (NBS981, 206Pb/207Pb =1.093) to an unfiltered sample, and followed the dissolved isotope composition of the mixture during the following two months. The initial dissolved Pb concentration was 18.3 pmol/kg with 206Pb/207Pb of 1.200. "Total dissolvable" Pb released after acidification of the in the unfiltered sample was 373 pmol/kg with 206Pb/207Pb of 1.199, indicating that there is a large particulate Pb reservoir with an isotopic composition comparable to regional crustal natural Pb. The isotope spike should have brought the dissolved 206Pb/207Pb to 1.162, but less than a day after isotope spiking, the dissolved Pb had risen to 1.181 and continued a slow increase to 1.197 over the next two months. This experiment demonstrates that Johor estuary particulate matter contains a large reservoir of exchangeable Pb that will modify the isotopic composition of deposited aeolian aerosol anthropogenic Pb. We have modeled the evolution of Pb and Pb isotopes in this experiment with a single Kd -type model that assumes that there are two or three different Pb reservoirs with different exchange time constants. This observation has implications for isotope equilibrium between high Pb/210Pb continental particles and low Pb/210Pb ocean waters - what is merely isotope equilibration may appear to be 210Pb scavenging.

  5. Copper and lead isotopic and metallic pollution record in soils from the Kombat mining area, Namibia

    Mihaljevic, Martin; Ettler, Vojtech; Vanek, Ales; Chrastny, Vladislav; Kribek, Bohdan; Penizek, Vit; Sracek, Ondrej

    2013-04-01

    Copper (Cu) and lead (Pb) concentration, isotopic composition (206Pb/207Pb, 65Cu/63Cu) and speciation were studied in soils from the Kombat mining area. The Cu and Pb concentrations in the studied soils ranged between 21 mg/kg - 757 mg/kg, and 19 mg/kg - 815 mg/kg respectively. In the sequential extractions, the largest part of soil Cu appeared in the residual and reducible fractions and Pb was predominantly bound in reducible and residual fractions and was more mobile compared to Cu. Copper and Pb concentration are higher in soils close to the slime deposit. Concentration of both metals increased with increasing soil depth in irrigated and cultivated soils. In soils not contaminated by dust eroded from the slime deposit, Cu and Pb contents are not dependent on the soil depth. The Pb isotopic signatures (206Pb/207Pb) ranged between 1.15 - 1.21 in soils from the Kombat area. In most of soil samples, surface horizons exhibited lower 206Pb/207Pb ratio, which originates from the slime dust pollution (206Pb/207Pb ~ 1.15) compared to deeper soil horizons, with lithogenic Pb signatures (206Pb/207Pb > 1.2). Isotopic composition of Cu differs on contaminated and uncontaminated sites and cultivated and non-cultivated sites. The δ65Cu in the studied soil horizon ranged between -0.373 ‰ and 0.561 ‰. The most pronounced variations occurred in contaminated non cultivated and non-irrigated soils (0.529 ‰). The contaminated top horizons are enriched in isotopically heavier Cu (tailing materials), and δ65Cu decreased with depth. Irrigated (cultivated) and contaminated soils exhibited heavier Cu in the surface horizons (originated from tailing dust δ65Cu = 0.260), decrease of δ65Cu in Bt horizons (biological uptake of light isotope by crop, and their incorporation in this horizons) and increase of δ65Cu in Bc horizons. The Bc horizons of cultivated and irrigated Phaeozems are enriched in Mn nodules (0.2 - 1.5 cm diameter, prevailing Mn phase pyrochroite Mn(OH)2) which

  6. Ancient Pb and Ti mobilization revealed by Scanning Ion Imaging

    Kusiak, Monika A.; Whitehouse, Martin J.; Wilde, Simon A.

    2014-05-01

    Zircons from strongly layered early Archean ortho- and paragneisses in ultra-high temperature (UHT) metamorphic rocks of the Napier Complex, Enderby Land, East Antarctica are characterized by complex U-Th-Pb systematics [1,2,3]. A large number of zircons from three samples, Gage Ridge, Mount Sones and Dallwitz Nunatak, are reversely discordant (U/Pb ages older than 207Pb/206Pb ages) with the oldest date of 3.9 Ga [4] (for the grain from Gage Ridge orthogneiss). To further investigate this process, we utilized a novel high spatial resolution Scanning Ion Imaging technique on the CAMECA IMS 1280 at the Natural History Museum in Stockholm. Areas of 70 μm x 70 μm were selected for imaging in mono- and multicollection modes using a ~2 μm rastered primary beam to map out the distribution of 48Ti, 89Y, 180Hf, 232Th, 238U, 204Pb, 206Pb and 207Pb. The ion maps reveal variable distribution of certain elements within analysed grains that can be compared to their CL response. Yttrium, together with U and Th, exhibits zonation visible on the CL images, Hf shows expected minimal variation. Unusual patchiness is visible in the map for Ti and Pb distribution. The bright patches with enhanced signal do not correspond to any zones or to crystal imperfections (e.g. cracks). The presence of patchy titanium is likely to affect Ti-in-zircon thermometry, and patchy Pb affecting 207Pb/206Pb ages, usually considered as more robust for Archean zircons. Using the WinImage program, we produced 207Pb/206Pb ratio maps that allow calculation of 207Pb/206Pb ages for spots of any size within the frame of the picture and at any time after data collection. This provides a new and unique method for obtaining age information from zircon. These maps show areas of enhanced brightness where the 207Pb/206Pb ratio is higher and demonstrate that within these small areas (μm scale) the apparent 207Pb/206Pb age is older, in some of these patches even > 4 Ga. These data are a result of ancient Pb

  7. The Chronology of Asteroid Accretion, Differentiation, and Secondary Mineralization

    Nyquist, L. E.; Kleine, T.; Shih, C.-Y.; Reese, Y. D.

    2008-01-01

    We evaluate initial (Al-26/Al-27)(sub I), (Mn-53/Mn-55)(sub I), (Hf-182/Hf-180)(sub I), and Pb-207/Pb-206 ages for igneous differentiated meteorites and chondrules from ordinary chondrites for consistency with radioactive decay of the parent nuclides within a common, closed isotopic system, i.e., the early solar nebula. We find that the relative abundances of Al-26, Mn-53, and Hf-182, here denoted by I(Al)(sub CAI, I(Mn)(sub CAI) and I(Hf)(sub CAI), are consistent with decay from common initial values for the bulk solar system. I(Mn)(sub CAI) and I(Hf)(sub CAI) = 9.1+/-1.7 x 10(exp -6) and 1.06+/-0.09 x 10(exp -6) respectively, correspond to the canonical value of I(Al)(sub CAI) = 5.1 x 10(exp -5). I(Hf)(sub CAI) thus determined is consistent with I(Hf)(sub CAI) = 1.003+/-0.045 x 10(exp -6) directly determined in separate work. I(Mn)(sub CAI) is within error of the lowest value directly determined for CAI. We suggest that erratically higher values directly determined for CAI in carbonaceous chondrites reflect proton irradiation of unaccreted CAIs by the early Sun after other asteroids destined for melting by Al-26 decay had already accreted. The Mn-53 incorporated within such asteroids would have been shielded from further "local" spallogenic contributions. The relative abundances of the short-lived nuclides are less consistent with the Pb-207/Pb-206 ages of the corresponding materials with the best consistency being obtained between (Hf-182/Hf-180)(sub I) and Pb-207/Pb-206 ages of angrites. (Hf-182/Hf-180)(sub I) decreases with decreasing Pb-207/Pb-206 ages at the rate expected from the 8.90+/-0.09 Ma half-life of Hf-182. However, the model "CAI age" thus determined, T(sub CAI,Mn-W) = 4568.6+/-0.7 Ma, is older than the commonly accepted directly measured value T(sub CAI) = 4567.l+/-0.2 Ma. I(Al)(sub I), and (Mn-53/Mn-55)(sub I) are less consistent with Pb-207/Pb-206 ages, but determine T(sub CAI, Mn-Cr) = 4568.3+/-0.5 Ma relative to I(AI)(sub CAI)= 5.1 x 10(exp -5

  8. GenBank blastx search result: AK061863 [KOME

    Full Text Available ome 6q13-15 Contains the 3' part of the BCKDHB gene for branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease), complete sequence.|PRI PRI 2e-47 +2 ...

  9. GenBank blastx search result: AK105761 [KOME

    Full Text Available ome 6q13-15 Contains the 3' part of the BCKDHB gene for branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease), complete sequence.|PRI PRI 1e-115 +2 ...

  10. GenBank blastx search result: AK104686 [KOME

    Full Text Available ome 6q13-15 Contains the 3' part of the BCKDHB gene for branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease), complete sequence.|PRI PRI 1e-48 +1 ...

  11. GenBank blastx search result: AK060465 [KOME

    Full Text Available osome 10 Contains the 3' end of a novel gene (FLJ37306), a novel gene and a ribosomal protein S27 (metallopanstimulin 1) (RPS27) pseudogene, complete sequence.|PRI PRI 1e-47 +1 ...

  12. GenBank blastx search result: AK110355 [KOME

    Full Text Available osome 10 Contains the 3' end of a novel gene (FLJ37306), a novel gene and a ribosomal protein S27 (metallopanstimulin 1) (RPS27) pseudogene, complete sequence.|PRI PRI 5e-90 +3 ...

  13. Partopreninte la Unuan Azian Kongreson

    UEDA Tomohiko

    1996-01-01

    Mi opinias,ke la kongresaj aranoj estisbonege faritaj pro la atentaj prizorgoj de KAEM(Komisiono de UEA pri Azia Esperanto-Mova-do).Mi iom skribos pri miaj personaj impresoj.Dum la kongreso mi estis relative diligenta

  14. A Brief Analysis on the Application of E-learning in Pri-mary and Secondary School Teachers Training%浅析E-learning在中小学教师培训中的应用

    葛吉雪

    2016-01-01

    培训是提升教师的教育教学技能与实践创新能力的重要途径.要让e-learning在中小学教师培训中发挥作用,就必须充分认识e-learning在教师培训中的必要性、加强e-learning基础设施建设、拓展e-learning资源、以多元方式对参训教师进行激励与评价.%Training is an important way to improve teachers' edu-cation teaching skills and practice the innovation capability. If e-learning plays a role in primary and secondary school teachers training, we should fully recognize e-learning's necessity in teachers training, strengthen infrastructure construction and ex-pand resources of e-learning. And we also should stimulate and evaluate teachers with multiple ways.

  15. PBL模式对小学英语自我效能的影响%The Influence of PBL Model on the Self-efficacy of Pri-mary School English

    何轶君

    2016-01-01

    自我效能是人们对自己能否成功完成某任务的主观判断,它与学业成就之间存在显著相关性.作为以学习者为中心的学习模式,PBL模式有诸多优点.它可以为学习者提供成功体验、替代经验、言语劝说及积极的情感体验,而这些正是自我效能的四种主要来源.但目前国内外相关实证研究还很少.通过实验研究,笔者发现PBL模式学习能够显著提高小学生的英语自我效能.此外,笔者还通过调查研究弄清了其途径,并以此为依据提出了对英语教学的启示.%Self-efficacy is people's subjective judgment on whether they can successfully complete a certain task, and it has significant correlation with academic achievement. As a learn-er-centered learning model, PBL model has many advantages. It can provide learners with successful experience, vicarious expe-rience, verbal persuasion and positive emotional experience which are the very four sources of self-efficacy. But there are few relevant empirical studies at home and abroad currently. Through experimental studies, the writer found that PBL model can signif-icantly improve the self-efficacy of primary school English. Be-sides, the writer also made clear its approaches through investi-gations and studies, and proposed the inspirations for English teaching based on this.

  16. Analysis of Status of Self-esteem of College Students in the Public and Pri-mary Medical Colleges%公办与民办医学院校大学生自尊现状分析

    徐洪岩; 傅茂笋

    2016-01-01

    大学生的自尊与心理健康有着密不可分的联系,自尊已经成为大学生心理健康的关键指标。如今,民办与公办医学院校大学生自尊存在很大的差异性,导致这种差异存在的因素比较多。该文详细分析大学生自尊现状以及差异性存在的原因,认为应在全员育人理念的指导下,有针对性地进行分析研究,并针对存在的问题及时调整对策。%With the rapid development of society and ever increasing social rhythm, the employment pressure of college students is rising, and in terms of age, the college students have entered into the adult stage, but their minds are not very mature, facing the fierce social competition, they are difficult to truly resolve the confusion, thus leading to mental issues. The research shows that the self-esteem of college students is closely related to the mental health, and the self-esteem has been the key indicator of mental health of college students, now, there is a big difference in the self-esteem of college stu-dents between the public and primary medical colleges with many causes, and the teachers and education managers in the medical colleges must analyze the difference causes of self-esteem of college students in detail, and we should carry out the targeted analysis and research and adjust strategies in time for the existing issues under the concept of total education.

  17. Dosage of loading at elementary training technique of receptions of game volleyball of tall girls 13-14 years [Dozirovanie nagruzki pri nachal'nom obuchenii tekhnike priemov igry volejbol vysokoroslykh devochek 13-14 let

    Selezneva O.V.

    2011-11-01

    Full Text Available Considered features of the elementary training technique basic the reception of playing volley-ball of tall girls. These intensities of implementation of exercises are resulted on physical and technical preparation. It is marked that the trainings loadings must be determined the followings indexes: intensity of work, volume (by duration of work, duration and character of intervals of rest between separate exercises. It is set that on the first stage of teaching the index of intensity of implementation of exercises makes 100-120 shots/minute. It is marked that on the second stage this index makes 120-140 shots/minute. On the third stage - 140-160 shots/minute. In this period of exercise on physical preparation must be executed with maximal intensity.

  18. 对少数民族双语教育幼小衔接的思考%A Discussion on the Linking Between Kindergarten and Pri mary School in Bilingual Education for Ethnic Minority Groups

    帕丽达·阿哈斯; 王善安

    2012-01-01

      搞好少数民族双语教育的幼小衔接有利于多元文化的发展,帮助儿童语言及学业成绩的提高。双语教育幼小衔接的目标可以分为直接目标与间接目标。在实施双语教育幼小衔接时应注意双语教育目标的小步化,双语教育内容生活化,双语教育组织统整化,双语教育实施活动化。%  The linking between kindergarten and primary school in bilingual education for ethnic minority groups is important for the multicultural development of Xinjiang and for the improvement of ethnic children 's language and education.The target of linking program consists of direct goal and indirect goal .In the practice of the linking project, the target of bilingual education should be reachable , the content of the bilingual educa-tion should be connected with their daily life , and the structure of the bilingual education should be systemic , and the teaching mode of the bilingual education should be activity -oriented.

  19. Analysis on the Application of Stratified Teaching to Pri- mary School Mathematics Classroom Teaching%分层教学在小学数学课堂教学中运用的分析

    倪晓燕

    2013-01-01

      分层教学如果恰当地运用到小学数学课堂上,能够满足学习水平存在差异学生的不同需求、促进数学教学水平的提高。本文分析了分层教学的意义以及在应用中应注意一些问题,以期为教学提供参考。%The application of stratified teaching to primary school mathematics classroom teaching can meet students' different needs in accordance with their different levels, so it can improve the teaching level of mathematics. This paper analyzes the signif-icance of stratified teaching and the issues that should be noticed in its application.

  20. Remedies to Fraud in Documentary Letters of Credit: A Comparative Perspective / Opravné Opatrenia Pri Podvodoch S Dokumentárnymi Akreditívami: Komparatívna Perspektíva

    Alavi Hamed

    2016-06-01

    Full Text Available Article 4 of the Unified Customs and Practices of Documentary Letters of Credit establishes the notion of autonomy principle by separating credit from underlying contract between account party and beneficiary. Article 5 by recognizing the autonomy principle confirms that effectuate the payment under credit, banks only deal with documents and not with goods. As a result, while documentary letters of credit are meant to facilitate the process of international trade, their sole dependency on compliance of presented documents to bank by beneficiary to actualize the payment will increase the risk of fraud and forgery in the course of their operation. Interestingly, UCP (currently UCP600 takes a silent status regarding the problem of fraud in international LC operation and leaves the ground open for national laws to provide remedies to affected parties by fraudulent beneficiary. National Laws have different approaches to the problem of fraud in general and fraud in international LC operation in particular which makes the access of affected parties to possible remedies complicated and difficult. Current paper tries to find answer to the questions of (i what available remedies are provided to affected parties in international LC fraud by different legal systems? (ii And what are conditions for benefiting from such remedies under different legal systems? In achieving its objective, paper will be divided in two main parts to study remedies provided by intentional legal frameworks as well as the ones offered by national laws. Part one will study the position of UCP and UNCITRAL Convention on Independent Guarantees and Standby Letters of Credit (UNCITRAL Convention and remedies, which they provide to LC fraud in international trade. Part two in contrary will study available remedies to LC fraud and condition for access them under English and American legal system.

  1. Using didactic enclosures as teaching methods and social forms for active learning in chemical education: Nekateri didaktični sklopi učnih metod/socialnih oblik aktivnega učenja pri predmetu kemija:

    Sikošek, Darinka

    2008-01-01

    Innovative teaching and learning can be defined as the effective use of various didactic materials combined with the methods and social forms of active learning. We carried out an evaluation of didactic enclosures as the initial stage in the methodology of our scientific strategy for researching the project "Didactic Redevelopment of Chemical Education in Slovenian Elementary Education". To obtain the results of our evaluation of didactic enclosures we concentrated on the innovative approach ...

  2. Plan Estratégico de Mercadeo PriCo Soluciones de Movilidad Posicionamiento y Ampliación del Mercado para el Servicio Administración y Logística de Parqueaderos en Cali.

    2012-01-01

    El objetivo principal del Plan de Mercadeo está basado en definir estrategias y desarrollar programas que permitan posicionar su servicio administración y logística de parqueaderos en la ciudad de Cali, así como también ampliar su mercado atendido. Para el alcance del objetivo identificamos los factores que afectan la movilidad en la ciudad de Cali relacionados principalmente con el estacionamiento vehicular; así mismo segmentar el mercado permite el desarrollo de estrategias enfocadas en ...

  3. Segmentácia trhu pri použití marketingových dát ako súčasť marketingovej stratégie

    Nagyová-Tkáčová, Monika

    2013-01-01

    The thesis deals mainly with market segmentation which is very important part of marketing strategy. The theoretical part consists of general knowledge of marketing, a Customer relationship management (CRM), market segmentation and database marketing. A case study consists of the implementation of the theoretical knowledge into the practical part. The aims of the thesis are: an introduction to the issue of market segmentation, an importance of market segmentation in creating marketing strateg...

  4. CFG桩清泥处理时机选择研究邹艳萍(1979.),女,工程师%Research on timing choice for silt-cleaning treatment of CFG pries

    杨帅; 邹艳萍

    2011-01-01

    以某高铁路基工程为例,针对CFG桩清泥处理时机选择进行了研究,结合管内泵压混合料灌注流程,分别阐述了钻泥清理方法选择和湿法机械清理钻泥时机选择,并指出了清理钻泥注意事项,以指导今后CFG桩施工。%Taking the foundation project of some express railway as the example, the paper researches the timing choice for silt-cleaning treat- ment of CFG piles, illustrates the cleaning method of drilling silt and the drilling timing choice for the wet mechanic silt cleaning by combining with the grouting procedure for the pumped and injected with grouting mixture, and points out the precautions for the silt-cleaning, so as to direct the future CFG pile construction.

  5. Aplikacija teoretičnega modela Imogene M. King pri obravnavi starostnika s sladkorno boleznijo: Aplication of the Imogene M. King's nursing model in the treatment of elderly diabetes patients:

    2009-01-01

    Introduction: The paper defines the problem of aging and presents the types ofdiabetes according to the American Diabetes Association, epidemiology of thedisease and the elderly diabetes patients in their social roles within the family and society. The basic principles of therapeutic communication with an elderly person are described. Imogene M. King's nursing model of goal attainment was used to ensure the holistic approach and treatment of the diseased elderly. Aim: The goal of the study wa...

  6. La crisis de la seguridad pública y los resultados electorales en el retorno del PRI a Nuevo León. Un análisis retrospectivo

    Laura Nelly Medellín Mendoza

    2016-01-01

    Full Text Available En este artículo se revisa la problemática reciente de la seguridad en la agenda pública de Nuevo León. Se destaca el efecto en los resultados electorales para el partido gobernante, tanto en elecciones intermedias como en la sucesión por la gubernatura. En ese sentido, el periodo de gobierno de 2003 a 2009 tuvo que enfrentar los altos índices delictivos con promulgación de leyes y políticas públicas, para marcar una reestructuración institucional en esta área. Se encontró evidencia de que el partido gobernante perdió espacios en los comicios intermedios en un contexto de gran inseguridad, pero esto no repercutió en la sucesión por la gubernatura, aunque los índices de homicidios por narcotráfico y la percepción de inseguridad ciudadana fueron altos hasta el término de la administración.

  7. Uso de la inmunohistoquímica para la búsqueda de proteínas priónicas en tercer párpado de ovinos en Chile

    G Farías

    2014-01-01

    Full Text Available En este trabajo se implementó y aplicó un método para detectar el scrapie, utilizando la técnica de inmunohistoquímica (IHQ en tejido linfoide de tercer párpado ovino. Este método permitiría realizar el diagnóstico en animales vivos, incluso en fases preclínicas de esta enfermedad en la masa ovina nacional. Se obtuvieron y procesaron 80 muestras de tercer párpado de ovinos nacionales mayores de 2 años, 42 con sintomatología nerviosa compatible con scrapie y 38 que fueron obtenidos de mataderos. Otras 13 muestras ciegas de validación de tercer párpado y sus respectivos óbex, además de 16 muestras de óbex utilizadas como controles, fueron aportadas por un Centro de Referencia (CR. Las muestras fueron evaluadas en cortes teñidos con Hematoxilina-Eosina y clasificadas como aptas cuando presentaban al menos 4 folículos linfoides en el tejido obtenido. Sobre esta base, 74 de las 93 muestras totales de tercer párpado fueron consideradas como aptas. Los resultados de IHQ mostraron que todas las muestras nacionales fueron negativas a scrapie y sólo 7 de las proporcionadas por el CR fueron positivas. Además, en todos los controles positivos de óbex se observó inmunomarcaje de PrP Sc, lo cual no se evidenció en los controles negativos. Los resultados descritos anteriormente permiten demostrar la aplicabilidad y capacidad para utilizar esta herramienta diagnóstica en la masa ovina, lo cual permitiría establecer la condición del país respecto al scrapie y obtener los beneficios de esta situación sanitaria.

  8. Role of tectonics, volcanism and climate during sedimentation of the Autunian series in the Inner Sudeten basin. Role tektoniky, vulkanizmu a klimatu pri sedimentaci olivetinskych vrstev (Autun) ve Vnitrosudetske panvi

    Blecha, M. (Univerzita Karlova, Prague (Czech Republic). Prirodovedecka Fakulta)

    1993-01-01

    Discusses paleoenvironment of the Autunian series in the Inner Sudeten basin with coal-bearing strata. The following aspects are evaluated: position of the Autunian series (to 200 m thick) in the basin, types of sedimentary rocks, sequences of sedimentation and their interpretation, alluvial sediments, river depositions, saline lakes and their deposits, manifestations of tectonic activity, deposit tectonics, effects of tectonics on strata inclination, secondary lake deposits, volcanic activity and types of volcanic rocks. The following stages of deposit accumulation are analyzed: alluvial sedimentation, volcanism, erosion, deposition of volcanic breccia in low zones, repeated deposition, effects of climate changes. 11 refs.

  9. Complex Coherent Interference Suppression Method Based on Random Variable PRI%基于随机变 T 的抗复合相干干扰方法的目标检测性能

    朱振波; 汤子跃; 王亚洲; 马少博

    2015-01-01

    Coherent radar is jammed through modulating and repeating the radar signals based on detecting and recognizing radar signal parameter. To confront the enemy reconnaissance effec-tively, a method of two pulses MTI cascade sliding window (non-coherent) detection is put for-ward. Compared to full coherent work, the radar performance of this method is declined, but it can work under the background of composite coherent jamming. Theoretical analysis and simula-tion results demonstrate the effectiveness and universality of this method.%现代干扰机能通过侦察识别雷达发射信号参数,并调制转发以实现对相参雷达的干扰。为有效对抗敌方侦察,针对上述方式,提出了随机变 T+2脉冲 MTI 再级联滑窗(非相参)检测的抗干扰方法。该方法较全相参工作时性能略有下降,但提升了雷达在复合相关干扰背景下的工作性能,仿真结果证明了该方法的有效性。

  10. Femoral Neck Fracture Treated with Percutaneous Pryed Reduction and External Fixation Apparatus:105 Cases Report%撬拨复位外固定治疗股骨颈头颈型骨折(附105例报告)

    金军; 徐海涛; 杨顺; 苏纪权; 刘志升

    2004-01-01

    目的:探讨钢针撬拨复位在治疗股骨颈骨折中的应用价值.方法:对105例股骨颈头颈型骨折施行钢针撬拨复位结合三针锁针加压器治疗,术后随访观察骨折愈合优良率及后期股骨头坏死率.结果:105例病人均获得随访.随访时间2.5~6年,平均3.5年,其中:功能接近正常者共91例,占86.6%.骨折愈合94例,占89.5%.其中并发股骨头坏死6例.骨折不愈合10例,占9.5%.死亡1例,占0.9%.无1例院内感染.结论:钢针撬拨复位可使骨折断端紧密对合,达到解剖复位,只要掌握手术适应证,遵循手术操作原则,术后针道常规处置,半介入式外固定器的并发症一般是可以避免的,因此有着良好的应用前景.

  11. An Accurate Estimation for PRI Rate-of-Change with the Coherent Pulse Train%相参脉冲序列PRI变化率的高精度估计方法

    周龙健; 罗景青

    2014-01-01

    在单站无源定位与跟踪系统中,PRI变化率信息反映了运动目标的径向加速度信息.提出了一种新的PRI变化率估计的算法,利用脉冲载频之间的相参积累,使信噪比得到提高,通过群延迟,使PRI的变化量得到积累,推导出一种快速而精确测量PRI变化率的算法,数值仿真证明使用该算法可以精确快速地估计信号中的PRI变化率信息.

  12. A Radar Signal Main Sorting Algorithm Based on PRI Entropy and Transfer Matrix%基于PRI熵和转移矩阵的雷达信号主分选算法

    李星雨; 杨承志; 张荣

    2013-01-01

    雷达信号实时分选是电子侦察的关键技术之一,针对传统主分选算法存在的缺陷,提出一种基于PRI熵和转移矩阵的主分选算法.该方法采用先整体后局部的思想,首先通过PRI熵信息找到复杂度低的区域,然后统计转移矩阵完成PRI估计,最后进行前后序列搜索.仿真实验验证了该方法的有效性.

  13. PRI信令在电力系统通信中出现2M板闭锁的问题%Problem of the PRI Signaling in Power Grid Communication Creating Barring of 2M Board

    万清

    2006-01-01

    电力通信程控交换机的技术发展很快,以ISDN PRI信令组网方式在电力通信网中得到了广泛的应用,ISDN PRI信令组网优势越来越明显.由于PRI信令在实际过程中会出现2 M板闭锁(退出服务)的问题,对此介绍了所产生的几种主要原因和故障排除的方法和处理流程.

  14. Non-Canonical Processing of Arabidopsis pri-miR319a/b/c Generates Additional microRNAs to Target One RAP2.12 mRNA Isoform.

    Sobkowiak, Lukasz; Karlowski, Wojciech; Jarmolowski, Artur; Szweykowska-Kulinska, Zofia

    2012-01-01

    Arabidopsis miR319a/b/c primary transcripts are unusual due to the presence of a long stem and loop structure containing functional miR319a/b/c molecules. In our experiments carried out using high throughput sequencing (HTS), we have shown that additional microRNAs (miRNAs), miR319a.2/b.2/c.2 are generated from the upper part of the same hairpin structure. We have also found cognate miRNAa.2*/b.2*/c.2* to be present in the HTS results with a considerably lower number of reads. Northern hybridization revealed that miR319b.2 is mainly expressed in 35-day-old plant rosette leaves, as well as in stem and inflorescences of 42- and 53-day-old plants. Moreover, it carries multiple signatures of a functional miRNA, including as follows: (i) its biogenesis is HYL1-dependent; (ii) it is incorporated in a substantial amount into RISC complexes containing AGO1, AGO2, or AGO4 protein; (iii) 24 nt-long species of miR319b.2 have been found in inflorescences to be more abundant than 21 nt miR319b.2 species; (iv) it is present in various ratios to miR319b during plant development, which suggests the existence of a regulatory mechanism responsible for its biogenesis/processing; (v) there is an observed cross-species conservation of the miR319a/b/c stem nucleotide sequence extending beyond mature miRNA region; and (vi) all evidence suggests that intron-containing RAP2.12 mRNA isoform is the target for miR319b.2. All these features prompt us to claim miR319b.2 as a functional miRNA molecule.

  15. SNP-SNP interactions of three new pri-miRNAs with the target gene PGC and multidimensional analysis of H. pylori in the gastric cancer/atrophic gastritis risk in a Chinese population.

    Xu, Qian; Wu, Ye-Feng; Li, Ying; He, Cai-Yun; Sun, Li-Ping; Liu, Jing-Wei; Yuan, Yuan

    2016-04-26

    Gastric cancer (GC) is a multistep complex disease involving multiple genes, and gene-gene interactions have a greater effect than a single gene in determining cancer susceptibility. This study aimed to explore the interaction of the let-7e rs8111742, miR-365b rs121224, and miR-4795 rs1002765 single nucleotide polymorphisms (SNPs) with SNPs of the predicted target gene PGC and Helicobacter pylori status in GC and atrophic gastritis (AG) risk. Three miRNA SNPs and seven PGC SNPs were detected in 2448 cases using the Sequenom MassArray platform. Two pairwise combinations of miRNA and PGC SNPs were associated with increased AG risk (let-7e rs8111742 - PGC rs6458238 and miR-4795 rs1002765 - PGC rs9471643). Singly, miR-365b rs121224 and PGC rs6912200 had no effect individually but in combination they demonstrated an epistatic interaction associated with AG risk. Similarly, let-7e rs8111742 and miR-4795 rs1002765 SNPs interacted with H. pylori infection to increase GC risk (rs8111742: Pinteraction = 0.024; rs1002765: Pinteraction = 0.031, respectively). A three-dimensional interaction analysis found miR-4795 rs1002765, PGC rs9471643, and H. pylori infection positively interacted to increase AG risk (Pinteraction = 0.027). Also, let-7e rs8111742, PGC rs6458238, and H. pylori infection positively interacted to increase GC risk (Pinteraction = 0.036). Furthermore, both of these three-dimensional interactions had a dosage-effect correspondence (Ptrend < 0.001) and were verified by MDR. In conclusion, the miRNAs SNPs (let-7e rs8111742 and miR-4795 rs1002765) might have more superior efficiency when combined with PGC SNPs and/or H. pylori for GC or AG risk than a single SNP on its own.

  16. 一种PRI变换并行处理算法及在高速DSP上的实现%Parallel Processing Algorithm for PRI Transform and Realization Based on High Speed DSP Platform

    鲍庆龙; 杨剑; 陈曾平

    2009-01-01

    脉冲重复间隔是雷达信号分选的关键参数.改进的PRI变换法克服了直方图统计法的子谐波问题,对脉冲重复间隔具有很高的估计精度,且具有一定的抗抖动能力.由于需要进行大量的指数运算和复数运算,故PRI变换法运算速度较慢,难以满足实时性要求.本文分析了改进的PRI变换法,提出了一种用于该算法并行处理的任务分配原则,并在TS201S平台上实现了改进的PRI变换算法.实验结果表明,基于该任务分配原则的PRI变换法并行处理大大提高了运算效率,能满足实时性要求.

  17. The optimization and application of PRI mode connecting with PBX in Ningxia Electric Power Administrative Exchange Network%PRI方式接入PBX在宁夏电力行政交换网中的优化和应用

    施科峰

    2009-01-01

    通过实例介绍了在宁夏电力行政交换网中,运用基群速率综合业务服务网(pRI)信令方式接入某些电厂或变电站的专用分组语音交换机(PBX)设备的两种方式.通过分析对比得到优选的接入方式,阐述了其实际推广使用的价值.

  18. 基于PRI接口的集中录音方式的应用%The Application of Centralized Recording Method in Power Communication System Based on PRI Interface

    施维刚

    2010-01-01

    基于ISDN的PRI接口在电力交换专网得到广泛应用,通过PRI接口实现集中录音功能既可以调高录音质量还可以提高录音系统的可靠性.文章通过MDR2000N录音记录仪与Coral交换机之间实现PRI接口集中录音的实例,说明了集中录音的实现原理和过程,并对实施过程中出现的主要问题进行了分析和说明,对基于PRI接口的集中录音方式在电力通信中的应用具有一定的借鉴作用.

  19. Type 1 Diabetes in the Young: Organization of two National Centers in Israel and Slovenia / Sladkorna Bolezen Tipa 1 Pri Otrocih in Mladostnikih: Organizacija Dela V Dveh Nacionalnih Centrih V Izraelu in Sloveniji

    Bratina Nataša

    2015-03-01

    Full Text Available Sladkorna bolezen tipa 1 je kronično avtoimuno obolenje, ki najpogosteje prizadene mlade ljudi. Incidenca bolezni zadnjih 50 let narašča po vsem svetu, v povprečju je letni porast incidence ocenjen na 4 %, ob tem pa starost bolnikov ob času diagnoze pada. Raziskave kažejo, da je dobra presnovna urejenost bolnikov s sladkorno boleznijo zelo pomembna, saj je s tem mogoče odložiti pozne zaplete bolezni ter izboljšati kvaliteto življenja bolnikov in njihovih družin. Neprekinjena edukacija bolnikov skupaj z možnostmi moderne tehnologije lahko prispeva k izboljšanju njihove presnovne urejenosti. Presnovno urejenost spremljamo z določanjem glikoziliranega hemoglobina (HbA1c ter s številom težkih hipoglikemij in ketoacidoz na populacijo pacientov v določenem časovnem obdobju. V prispevku sta opisana dva nacionalna referenčna centra za obravnavo otrok, mladostnikov in mladih odraslih s sladkorno boleznijo v Izraelu in Sloveniji.

  20. Anthropogenic and natural lead isotopes in Fe-hydroxides and Fe-sulphates in a watershed associated with arsenic-enriched groundwater, Maine, USA

    Ayuso, Robert A.; Foley, Nora K.

    2008-01-01

    A survey of the natural and anthropogenic sources of lead contributing to secondary minerals in sulphidic schists associated with arsenic-enriched groundwater in Coastal Maine shows that the most likely source is natural Pb, particularly from coexisting sulphide minerals. The secondary minerals also reflect notable contributions from anthropogenic Pb. The Pb isotopes establish pathways by which Pb, and by inference As, could have been transported from As-bearing minerals (arsenian pyrite, arsenopyrite, lollingite, orpiment, arsenic oxide and others), via sulphide oxidation or carbonation reactions into multiple generations of secondary minerals (goethite, hematite, jarosite, natrojarosite and others). Lead isotopic compositions of the sulphides and secondary minerals determined by thermal ionization mass spectrometry (n=53) range widely. Lead and As contents of the sulphides and secondary minerals overlap, and are generally positively correlated. Pyrite, the dominant sulphide in sulphidic schists associated with As-enriched groundwater in Coastal Maine, has values of 206Pb/204Pb from 18.186 to 18.391, 207Pb/204Pb from 15.617 to 15.657, 208Pb/204Pb from 38.052 to 38.210, 206Pb/207Pb from c. 1.1625 to 1.1760 and 208Pb/207Pb from c. 2.4276 to 2.4394. Mixtures of Fe-hydroxide and oxide minerals (predominantly goethite and hematite) and secondary Fe-sulphate minerals (jarosite, natrojarosite, rozenite and melanterite) in the sulphidic schists have overlapping but generally higher values of 206Pb/204Pb from 18.495 to 19.747 (one sample at 21.495), 207Pb/204Pb from 15.595 to 15.722 (one sample at 15.839), 208Pb/204Pb from 38.186 to 39.162,206Pb/207Pb from c.1.1860 to 1.2575 (one sample at 1.3855) and 208Pb/207Pb from c. 2.4441 to 2.4865 than the sulphides. Sulphides from Zn-Pb metal mines are somewhat less radiogenic than sulphides from the schists. Other sulphides (mostly pyrite) associated with pegmatites and granitic rocks are heterogeneous and more

  1. Tracing the transport of anthropogenic lead in the atmosphere and in soils using isotopic ratios

    Erel, Yigal; Veron, Alain; Halicz, Ludwik

    1997-11-01

    The isotopic composition of lead in aerosols and soils in Israel is used to characterize the sources of anthropogenic lead in the region, to ascertain the isotopic composition of natural, rock-derived lead in specific areas, and to determine rates of anthropogenic lead migration in soils. The isotopic composition of lead currently emitted from cars in Israel ( 206Pb /207Pb = 1.115 ± 2 ) is controlled by alkyl-lead produced in France and Germany. In addition to petrol-lead, two more sources of anthropogenic lead can be detected in sampled aerosols: the first one has low concentrations of lead (˜4 ng/m 3) and 206Pb /207Pb ˜ 1.157 , and is most likely lead, emitted in Turkey, that traveled across the eastern Mediterranean basin; the second type of aerosols contains a mixture of lead emitted in several countries including Turkey, Greece, and Ukraine ( 206Pb /207Pb value of 1.155-1.160; [Pb] ˜ 20-30 ng/m 3). Anthropogenic lead is more accessible for acid leaching than natural lead, therefore, it is more labile in the soil. The isotopic composition of lead in the acid-leached fraction of near-road soil profiles record the histor of alkyl-lead emission in the country. Based on changes in the isotopic composition of lead with soil depth, it is estimated that anthropogenic lead migrates into the soil at approximately 0.5 cm/y. A soil profile from a relatively remote area is less contaminated by anthropogenic lead and displays a different distribution of lead isotopic values with depth. The isotopic composition of lead suggests that natural lead in soils developed on carbonate bedrock is derived from clays, either from the rock-esidue (the clay fraction in the carbonate bedrock), or from airborne clay, but not from lead released from the carbonate fraction in the rock.

  2. Protolith ages and timing of peak and retrograde metamorphism of the high-pressure granulites in the Shandong Peninsula, eastern North China Craton

    Pinghua Liu

    2012-11-01

    Full Text Available High-pressure (HP granulites widely occur as enclaves within tonalite-trondhjemite-granodiorite (TTG gneisses of the Early Precambrian metamorphic basement in the Shandong Peninsula, southeast part of the North China Craton (NCC. Based on cathodoluminescence (CL, laser Raman spectroscopy and in-situ U-Pb dating, we characterize the zircons from the HP granulites and group them into three main types: inherited (magmatic zircon, HP metamorphic zircon and retrograde zircon. The inherited zircons with clear or weakly defined magmatic zoning contain inclusions of apatites, and 207Pb/206Pb ages of 2915–2890 Ma and 2763–2510 Ma, correlating with two magmatic events in the Archaean basement. The homogeneous HP metamorphic zircons contain index minerals of high-pressure metamorphism including garnet, clinopyroxene, plagioclase, quartz, rutile and apatite, and yield 207Pb/206Pb ages between 1900 and 1850 Ma, marking the timing of peak HP granulite facies metamorphism. The retrograde zircons contain inclusions of orthopyroxene, plagioclase, quartz, apatite and amphibole, and yield the youngest 207Pb/206Pb ages of 1840–1820 Ma among the three groups, which we correlate to the medium to low-pressure granulite facies retrograde metamorphism. The data presented in this study suggest subduction of Meso- and Neoarchean magmatic protoliths to lower crust depths where they were subjected to HP granulite facies metamorphism during Palaeoproterozoic (1900–1850 Ma. Subsequently, the HP granulites were exhumated to upper crust levels, and were overprinted by medium to low-pressure granulite and amphibolite facies retrograde event at ca. 1840–820 Ma.

  3. Isotopically constrained lead sources in fugitive dust from unsurfaced roads in the southeast Missouri mining district

    Witt, Emitt C.; Pribil, Michael; Hogan, John P; Wronkiewicz, David

    2016-01-01

    The isotopic composition of lead (Pb) in fugitive dust suspended by a vehicle from 13 unsurfaced roads in Missouri was measured to identify the source of Pb within an established long-term mining area. A three end-member model using 207Pb/206Pb and concentration as tracers resulted in fugitive dust samples plotting in the mixing field of well characterized heterogeneous end members. End members selected for this investigation include the 207Pb/206Pb for 1) a Pb-mixture representing mine tailings, 2) aerosol Pb-impacted soils within close proximity to the Buick secondary recycling smelter, and 3) an average of soils, rock cores and drill cuttings representing the background conditions. Aqua regia total concentrations and 207Pb/206Pb of mining area dust suggest that 35.4–84.3% of the source Pb in dust is associated with the mine tailings mixture, 9.1–52.7% is associated with the smelter mixture, and 0–21.6% is associated with background materials. Isotope ratios varied minimally within the operational phases of sequential extraction suggesting that mixing of all three Pb mixtures occurs throughout. Labile forms of Pb were attributed to all three end members. The extractable carbonate phase had as much as 96.6% of the total concentration associated with mine tailings, 51.8% associated with smelter deposition, and 34.2% with background. The next most labile geochemical phase (Fe + Mn Oxides) showed similar results with as much as 85.3% associated with mine tailings, 56.8% associated with smelter deposition, and 4.2% associated with the background soil.

  4. Subduction—Modified Subcontinental Mantle in South China:Trace Element and Isotope Evidence in Basalts from Hainan Island

    张明; 解广轰; 等

    1996-01-01

    Cenozoic lavas from Hainan Island,South China,comprise quartz tholeiite,olivine tholeiite,alkali basalt,and basanite and form a continuous,tholeiite-dominated,compositional spectrum.Highly incompatible elements and their relationships with isotopes in these lavas are shown to be useful in evaluating mantle-source composition,whereas modeling suggests that ratios of elements with bulk partition coefficients significantly larger than those of Nb and Ta may be sensitive to partial melting.Th/Ta and La/Nb ratios of alkali basalts are lower than those of tholeiites,and they are all lower than those of the primitive mantle,These ratios correlate positively with 207Pb/204Pb and 87Sr/86Sr ratios.Such relationships can be explained by mixing of depleted and enriched source components.A depleted component is indicated by alkali basalt compositions and is similar to some depleted OIB (PREMA).The enriched component,similar to sediment compositions,is indicated by tholeiites with high LILE/HFSE,207Pb/204Pb,and 87Sr/86Sr ratios.In general,basalts from Hainan and the South China Basin(SCB)share common geochemical characters.e.g.high Rb/Sr,Th/Ta,207Pb/206Pb,and low Ba/Th ratios.Such a geochemical trend is comparable to that of EMII-type OIB and best explained as the result of subduction.Occurrence of these characteristics in both continental Hainan basalts and SCB seamout basalts indicates the presence of a South China geochemical domain that exists in the mantle region below the lithosphere.

  5. Isotopically constrained lead sources in fugitive dust from unsurfaced roads in the southeast Missouri mining district.

    Witt, Emitt C; Pribil, Michael J; Hogan, John P; Wronkiewicz, David J

    2016-09-01

    The isotopic composition of lead (Pb) in fugitive dust suspended by a vehicle from 13 unsurfaced roads in Missouri was measured to identify the source of Pb within an established long-term mining area. A three end-member model using (207)Pb/(206)Pb and concentration as tracers resulted in fugitive dust samples plotting in the mixing field of well characterized heterogeneous end members. End members selected for this investigation include the (207)Pb/(206)Pb for 1) a Pb-mixture representing mine tailings, 2) aerosol Pb-impacted soils within close proximity to the Buick secondary recycling smelter, and 3) an average of soils, rock cores and drill cuttings representing the background conditions. Aqua regia total concentrations and (207)Pb/(206)Pb of mining area dust suggest that 35.4-84.3% of the source Pb in dust is associated with the mine tailings mixture, 9.1-52.7% is associated with the smelter mixture, and 0-21.6% is associated with background materials. Isotope ratios varied minimally within the operational phases of sequential extraction suggesting that mixing of all three Pb mixtures occurs throughout. Labile forms of Pb were attributed to all three end members. The extractable carbonate phase had as much as 96.6% of the total concentration associated with mine tailings, 51.8% associated with smelter deposition, and 34.2% with background. The next most labile geochemical phase (Fe + Mn Oxides) showed similar results with as much as 85.3% associated with mine tailings, 56.8% associated with smelter deposition, and 4.2% associated with the background soil.

  6. Measurement of the Cross Section for Prompt Diphoton Production in p-pbar Collisions at $\\sqrt{s}$ = 1.96 TeV

    Acosta, D; Affolder, T; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arisawa, T; Arguin, F; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi, P; Bacchetta; Bacchetta, N; Bachacou, H; Badgett, W; Barbaro-Galtieri, A; Galtieri; Barker, G J; Barnes, V E; Barnett, B A; Baroiant, S; Barone, M; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Ben-Haim, E; Benjamin, D; Beretvas, A; Bhatti, A A; Binkley, M; Bisello, D; Bishai, M; Blair, R E; Blocker, C; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Bölla, G; Bolshov, A; Booth, P S L; Bortoletto, D; Boudreau, J; Bourov, S; Brau, B; Bromberg, C; Brubaker, E; Budagov, Yu A; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canepa, A; Casarsa, M; Carlsmith, D; Carron, S; Carosi, R; Cavalli-Sforza, M; Castro, A; Catastini, P; Cauz, D; Cerri, A; Cerrito, L; Chapman, J; Chen, C; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Chu, M L; Chuang, S; Chung, J Y; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Clark, A G; Clark, D; Coca, M; Connolly, A; Convery, M; Conway, J; Cooper, B; Cordelli, M; Cortiana, G; Cranshaw, J; Cuevas-Maestro, J; Culbertson, R; Currat, C; Cyr, D; Dagenhart, D; Da Ronco, S; D'Auria, S; De Barbaro, P; De Cecco, S; Dell'Agnello, S; Dell'Orso, Mauro; Demers, S; Demortier, L; Deninno, M; De Pedis, D; Derwent, P F; Dionisi, C; Dittmann, J R; Dorr, C; Doksus, P; Dominguez, A; Donati, S; Donega, M; Donini, J; D'Onofrio, M; Dorigo, T; Drollinger, V; Ebina, K; Eddy, N; Ehlers, J; Ely, R; Erbacher, R; Erdmann, M; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernández, J P; Ferretti, C; Field, R D; Flanagan, G; Flaugher, B; Flores-Castillo, L R; Foland, A; Forrester, S; Foster, G W; Franklin, M; Freeman, J C; Fujii, Y; Furic, I; Gajjar, A; Gallas, A; Galyardt, J; Gallinaro, M; García-Sciveres, M; Garfinkel, A F; Gay, C; Gerberich, H; Gerdes, D W; Gerchtein, E; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Ginsburg, C; Giolo, K; Giordani, M; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, D; Goldstein, J; Gómez, G; Gómez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Gotra, Yu; Goulianos, K; Gresele, A; Griffiths, M; Grosso-Pilcher, C; Grundler, U; Günther, M; Guimarães da Costa, J; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B Y; Handler, R; Happacher, F; Hara, K; Hare, M; Harr, R F; Harris, R M; Hartmann, F; Hatakeyama, K; Hauser, J; Hays, C; Hayward, H; Heider, E; Heinemann, B; Heinrich, J; Hennecke, M; Herndon, M; Hill, C; Hirschbuehl, D; Höcker, A; Hoffman, K D; Holloway, A; Hou, S; Houlden, M A; Huffman, B T; Huang, Y; Hughes, R E; Huston, J; Ikado, K; Incandela, J R; Introzzi, G; Iori, M; Ishizawa, Y; Issever, C; Ivanov, A; Iwata, Y; Iyutin, B; James, E; Jang, D; Jarrell, J; Jeans, D; Jensen, H; Jeon, E J; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Kang, J; Karagoz-Unel, M; Karchin, P E; Kartal, S; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, M S; Kim, S B; Kim, S H; Kim, T H; Kim, Y K; King, B T; Kirby, M; Kirsch, L; Klimenko, S; Knuteson, B; Ko, B R; Kobayashi, H; Koehn, P; Kong, D J; Kondo, K; Konigsberg, J; Kordas, K; Korn, A J; Korytov, A; Kotelnikov, K; Kotwal, A V; Kovalev, A; Kraus, J; Kravchenko, I; Kreymer, A; Kroll, J; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, J; Lancaster, M; Lander, R; Lannon, K; Latino, G; Lauhakangas, R; Lazzizzera, I; Le, Y; Lecci, C; LeCompte, T; Lee, J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Li, K; Lin, C; Lin, C S; Lindgren, M; Liss, T M; Lister, A; Litvintsev, D O; Liu, T; Liu, Y; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P F; Lu, R S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; MacQueen, D; Madrak, R; Maeshima, K; Maksimovic, P; Malferrari, L; Manca, G; Marginean, R; Marino, C; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Matsunaga, H; Mattson, M; Mazzanti, P; McFarland, K S; McGivern, D; McIntyre, P M; McNamara, P; NcNulty, R; Mehta, A; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miller, L; Miller, R; Miller, J S; Miquel, R; Miscetti, S; Mitselmakher, G; Miyamoto, A; Miyazaki, Y; Moggi, N; Mohr, B; Moore, R; Morello, M; Movilla-Fernández, P A; Mukherjee, A; Mulhearn, M; Müller, T; Mumford, R; Munar, A; Murat, P; Nachtman, J; Nahn, S; Nakamura, I; Nakano, I; Napier, A; Napora, R; Naumov, D V; Necula, V; Niell, F; Nielsen, J; Nelson, C; Nelson, T; Neu, C; Neubauer, M S; Newman-, C; Holmes, J A; Nigmanov, T; Nodulman, L; Norniella, O; Österberg, K; Ogawa, T; Oh, S H; Oh, Y D; Ohsugi, T; Okusawa, T; Oldeman, R G C; Orava, R; Orejudos, W; Pagliarone, C; Palencia, E; Paoletti, R; Papadimitriou, V; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Pauly, T; Paus, C; Pellett, D; Penzo, Aldo L; Phillips, T J; Piacentino, G; Piedra, J; Pitts, K T; Plager, C; Pompos, A; Pondrom, L; Pope, G; Portell, X; Poukhov, O; Prakoshyn, F; Pratt, T; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Rademacker, J; Rahaman, M A; Rakitine, A; Rappoccio, S; Ratnikov, F; Ray, H; Reisert, B; Rekovic, V; Renton, P B; Rescigno, M; Rimondi, F; Rinnert, K; Ristori, L; Robertson, W J; Robson, A; Rodrigo, T; Rolli, S; Rosenson, L; Roser, R; Rossin, R; Rott, C; Russ, J; Rusu, V; Ruiz, A; Ryan, D; Saarikko, H; Sabik, S; Safonov, A; Saint-Denis, R; Sakumoto, W K; Salamanna, G; Saltzberg, D; Sánchez, C; Sansoni, A; Santi, L; Sarkar, S; Sato, K; Savard, P; Savoy-Navarro, A; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Scodellaro, L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semeria, F; Sexton-Kennedy, L; Sfiligoi, I; Shapiro, M D; Shears, T G; Shepard, P F; Sherman, D; Shimojima, M; Shon, Y; Shreyber, I; Sidoti, A; Siegrist, J; Siket, M; Sill, A; Sinervo, P; Sissakian, A N; Skiba, A; Slaughter, A J; Sliwa, K; Smirnov, D; Smith, J R; Snider, F D; Snihur, R; Soha, A; Somalwar, S V; Spalding, J; Spezziga, M; Spiegel, L; Spinella, F; Spiropulu, M; Squillacioti, P; Stadie, H; Stelzer, B; Stelzer-, O; Chilton; Strologas, J; Stuart, D; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Taffard, A C; Tafirout, R; Takach, S F; Takano, H; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tanimoto, N; Tapprogge, Stefan; Tecchio, M; Teng, P K; Terashi, K; Tesarek, R J; Tether, S; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tollefson, K; Tomura, T; Tonelli, D; Tonnesmann, M; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tseng, J; Tsuchiya, R; Tsuno, S; Tsybychev, D; Turini, N; Turner, M; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vacavant, L; Vaiciulis, A W; Varganov, A; Vataga, E; Vejcik, S; Velev, G V; Veszpremi, V; Veramendi, G; Vickey, T; Vidal, R; Vila, I; Vilar, R; Vollrath, I; Volobuev, I P; Von der Mey, M; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wallny, R; Walter, T; Yamashita, T; Yamamoto, K; Wan, Z; Wang, M J; Wang, S M; Warburton, A; Ward, B; Waschke, S; Waters, D; Watts, T; Weber, M; Wester, W C; Whitehouse, B; Wicklund, A B; Wicklund, E; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolter, M; Worcester, M; Worm, S; Wright, T; Wu, X; Würthwein, F; Wyatt, A; Yagil, A; Yang, C; Yang, U K; Yao, W; Yeh, G P; Yi, K; Yoh, J; Yoon, P; Yorita, K; Yoshida, T; Yu, I; Yu, S; Yu, Z; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhou, J; Zsenei, A; Zucchelli, S

    2004-01-01

    We report a measurement of the rate of prompt diphoton production in $p\\bar{p}$ collisions at $\\sqrt{s}$=1.96 ~\\hbox{TeV}$ using a data sample of 207 pb$^{-1}$ collected with the upgraded Collider Detector at Fermilab (CDF II). The background from non-prompt sources is determined using a statistical method based on differences in the electromagnetic showers. The cross section is measured as a function of the diphoton mass, the transverse momentum of the diphoton system, and the azimuthal angle between the two photons and is found to be consistent with perturbative QCD predictions.

  7. Regional variations in the lead isotopic composition of galena from southern Korea with implications for the discrimination of lead provenance

    Jeong, Youn-Joong; Cheong, Chang-sik; Shin, Dongbok; Lee, Kwang-Sik; Jo, Hui Je; Gautam, Mukesh Kumar; Lee, Insung

    2012-11-01

    This study presents a comprehensive database (n = 215) of lead isotopes in galena from the southern Korean peninsula using new and published data. Of the 69 metal mines examined, predominantly skarn- and hydrothermal-type Pb-Zn-Au-Ag-Cu deposits were observed and were associated with Mesozoic magmatic activities. Galena samples from each geotectonic unit showed discrete lead isotopic signatures. The Gyeongsang basin samples were characteristically unradiogenic and had restricted variations in lead isotopic composition (206Pb/204Pb = 18.16-18.59, 207Pb/204Pb = 15.48-15.64, 208Pb/204Pb = 37.87-38.77). Their 208Pb/204Pb range indicated an involvement of source materials less thorogenic than the associated granites. The galena samples from Cambro-Ordovician carbonate rocks of the northeastern Yeongnam massif and eastern Taebaeksan basin had the most radiogenic 206Pb/204Pb (19.28 ± 0.14) and 207Pb/204Pb (15.833 ± 0.027) ratios. Their lead isotopic trend indicated a combined contribution of ore lead from granitic magmas, Precambrian basements, and overlain host rocks. Less radiogenic galena samples from the middle to southwestern parts of the Yeongnam massif and Okcheon belt showed limited lead isotopic variations (206Pb/204Pb = 18.332 ± 0.065, 207Pb/204Pb = 15.693 ± 0.012, 208Pb/204Pb = 38.93 ± 0.07 on average), probably resulted from mixing with a common crustal basement. The differences in lead isotopes between the radiogenic and unradiogenic groups from the Yeongnam massif and Okcheon belt may reflect the spatial dissimilarity of involved crustal rocks. The old crust appears to have significantly contributed ore lead to galenas from the western Gyeonggi massif, but the geochronological meaning of their steep 207Pb/204Pb-206Pb/204Pb trend is not clear. The comprehensive database constructed by the present study suggests that lead province in the southern Korean peninsula may be subdivided into four discrete zones. Linear discriminant analysis showed that more

  8. 我国城市大气颗粒物的铅同位素丰度比

    刘咸德; 李显芳; 李冰

    2004-01-01

    Determined with ICP-MS, new isotope abundance ratio data of lead for Beijing and Changdao aerosols was presented, in comparison with literature data for Chinese urban aerosols. 206Pb/207Pb ratio falls into a range from 1.13 to 1.18 for urban aerosols and less influenced by vehicle exhaust emission after phase-out of leaded petrol in 2000 in China. Major lead pollution sources may probably include coal combustion, oil combustion,re-suspended dust, metallurgical industry and use and production of cement.

  9. 我国城市大气颗粒物的铅同位素丰度比%Lead Isotope Abundance Ratios of Urban Atmospheric Aerosols in China

    刘咸德; 李显芳; 李冰

    2004-01-01

    Determined with ICP-MS, new isotope abundance ratio data of lead for Beijing and Changdao aerosols was presented, in comparison with literature data for Chinese urban aerosols. 206Pb/207Pb ratio falls into a range from 1.13 to 1.18 for urban aerosols and less influenced by vehicle exhaust emission after phase-out of leaded petrol in 2000 in China. Major lead pollution sources may probably include coal combustion, oil combustion,re-suspended dust, metallurgical industry and use and production of cement.

  10. 阿伦德陨石白色包体中铅同位素组成的激光探针质谱分析

    柴之芳

    1984-01-01

    The attempt of this work is to use LAMMA, a newly developed modern micro-beam analytical technique, to determin the lead isotopic composition of some grains picked out from the white aggregates in the Allende (C3V) carbonaceous chondrite. Experimental results show that the Pb/Pb model age of the Allende calculated on the basis of the 206Pb/207Pb ratio is (4.56±0.008) AE, in good agreement with the value reported in literature.LAMMA provides a new and powerful tool in the analytical arsenal of trace elements and isotopic composition, due to its high sensitivity, rapid analysis and good space resolution.

  11. Three centuries of heavy metal pollution in Paris (France) recorded by urban speleothems

    Pons-Branchu, Edwige, E-mail: epons@lsce.ipsl.fr [LSCE (UMR8212, CEA/CNRS/UVSQ), Bâtiment 12, avenue de la Terrasse, 91198 Gif-Sur-Yvette (France); Ayrault, Sophie; Roy-Barman, Matthieu; Bordier, Louise [LSCE (UMR8212, CEA/CNRS/UVSQ), Bâtiment 12, avenue de la Terrasse, 91198 Gif-Sur-Yvette (France); Borst, Wolfgang; Branchu, Philippe [CEREMA, 12 rue Teisserenc de Bort, 78190 Trappes (France); Douville, Eric [LSCE (UMR8212, CEA/CNRS/UVSQ), Bâtiment 12, avenue de la Terrasse, 91198 Gif-Sur-Yvette (France); Dumont, Emmanuel [CEREMA, rue de l' égalité Prolongée, 93352, Le Bourget cedex 319 (France)

    2015-06-15

    The first record of urban speleothems used to reconstruct the history of heavy metal pollution of shallow groundwaters is presented. Two speleothems grew during the last 300 years in an underground aqueduct in the north-eastern part of Paris. They display high Pb, Mn V, Cu, Cd and Al concentrations since 1900 due to the urbanization of the site which triggered anthropogenic contamination of the water feeding the speleothems. Surprisingly, these heavy metal concentrations are also high in the oldest part. This early pollution could come from the use of Parisian waste as fertilizers in the orchards and vineyards cultivated above the aqueduct before urbanization. Lead isotopes were measured in these carbonates as well as in lead artifacts from the 17th–18th centuries ({sup 206}Pb/{sup 207}Pb = 1.180 +/− 0.003). The mean {sup 206}Pb/{sup 207}Pb ratio, for one of the speleothems is 1.181 +/− 0.003 unvarying with time. These lead signatures are close to those of coal and old lead from northern European mines, lower than the natural background signature. It confirms that the high metal concentrations found come from anthropogenic pollution. Conversely, the lead isotopic composition of the second speleothem presents two temporal trends: for the oldest levels, the mean value (1.183 +/− 0.003) is similar to the first speleothem. For the youngest part, a lower value (1.172 +/− 0.005) is recorded, evidencing the contribution of a new lead source at the beginning of the industrial revolution. Pb isotopes were also measured in recent samples from a nearby superficial site. The first sample is a recent (AD 1975 +/− 15 years) deposit ({sup 206}Pb/{sup 207}Pb = 1.148 +/− 0.003), and the second, a thin subactual layer ({sup 206}Pb/{sup 207}Pb = 1.181 +/− 0.002). These data are compatible with the adding of anthropogenic sources (leaded gasoline and industrial lead from Rio Tinto ore). - Highlights: • Urban speleothems from underground aqueduct in Paris, France were

  12. Antiproliferative Activity and in Vivo Toxicity of Double-Point Modified Analogs of 1,25-Dihydroxyergocalciferol.

    Trynda, Justyna; Turlej, Eliza; Milczarek, Magdalena; Pietraszek, Anita; Chodyński, Michał; Kutner, Andrzej; Wietrzyk, Joanna

    2015-10-20

    Analogs of 1,25-dihydroxyergocalciferol, modified in the side-chain and in the A-ring, were tested for their antiproliferative activity against a series of human cancer cell lines in vitro and in vivo toxicity. The proliferation inhibition caused by the analogs was higher than that of the parent compounds, while the toxicity, measured as the serum calcium level, was lower. All analogs were able to induce, in HL-60 and MV4-11 leukemic cells, G₀/G₁ cell cycle arrest and differentiation expressed as morphological signs typical for monocytes. The analogs also induced the expression of CD11b and/or CD14 cell-differentiation markers. The most potent analogs, PRI-5105, PRI-5106, PRI-5201 and PRI-5202, were also able to induce vitamin D receptor (VDR) protein expression, mainly in the cytoplasmic fraction of HL-60 or MV4-11 cells. The most active analogs were the 19-nor ones with an extended and rigidified side-chain (PRI-5201 and PRI-5202), as in the former analogs PRI-1906 and PRI-1907. Epimerization at C-24 (PRI-5101) or introduction of an additional hydroxyl at C-23 (PRI-5104) reduced the toxicity of the analog with retained antiproliferative activity.

  13. Antiproliferative Activity and in Vivo Toxicity of Double-Point Modified Analogs of 1,25-Dihydroxyergocalciferol

    Justyna Trynda

    2015-10-01

    Full Text Available Analogs of 1,25-dihydroxyergocalciferol, modified in the side-chain and in the A-ring, were tested for their antiproliferative activity against a series of human cancer cell lines in vitro and in vivo toxicity. The proliferation inhibition caused by the analogs was higher than that of the parent compounds, while the toxicity, measured as the serum calcium level, was lower. All analogs were able to induce, in HL-60 and MV4-11 leukemic cells, G0/G1 cell cycle arrest and differentiation expressed as morphological signs typical for monocytes. The analogs also induced the expression of CD11b and/or CD14 cell-differentiation markers. The most potent analogs, PRI-5105, PRI-5106, PRI-5201 and PRI-5202, were also able to induce vitamin D receptor (VDR protein expression, mainly in the cytoplasmic fraction of HL-60 or MV4-11 cells. The most active analogs were the 19-nor ones with an extended and rigidified side-chain (PRI-5201 and PRI-5202, as in the former analogs PRI-1906 and PRI-1907. Epimerization at C-24 (PRI-5101 or introduction of an additional hydroxyl at C-23 (PRI-5104 reduced the toxicity of the analog with retained antiproliferative activity.

  14. A method for intercalibration of U-Th-Pb and 40Ar- 39Ar ages in the Phanerozoic

    Villeneuve, Mike; Sandeman, Hamish A.; Davis, William J.

    2000-12-01

    The increasing analytical precision of 40Ar- 39Ar geochronological data and its use in studies that combine U-Pb and 40Ar- 39Ar data has necessitated derivation of a means to intercalibrate ages between the two isotopic systems. The primary determinants inhibiting accurate cross calibration are uncertainty in decay constant values and uncertainty in 40Ar∗/ 40K (usually presented as apparent age) for 40Ar- 39Ar standards, notably those derived from the Fish Canyon Tuff. By utilizing a monazite- and biotite bearing Oligocene ash flow tuff (MAC-83) as the primary standard material, precise U-Th-Pb and 40Ar- 39Ar ages can be derived. Because both isotopic systems should reflect closure during the instantaneous eruption event, the 24.21 ± 0.10 Ma 207Pb/ 235U age should match the age resulting from 40Ar- 39Ar biotite analysis. This forced equivalence will partly offset the effects of decay constant uncertainty. Furthermore, by co-irradiating Fish Canyon Tuff sanidine with MAC-83 biotite, the apparent age for Fish Canyon Tuff sanidine is back-calculated to 27.98 ± 0.15 Ma, relative to the MAC-83 207Pb/ 235U age. Hence, intercalibration between the two isotopic systems in a relative sense can be accomplished, allowing for a direct and valid comparison of ages. It is also shown that forcing equivalence of the two isotopic systems minimizes the effect of decay constant uncertainty for samples of Phanerozoic age.

  15. Identification of trace metal pollution in urban dust from kindergartens using magnetic, geochemical and lead isotopic analyses

    Zhu, Zongmin; Sun, Guangyi; Bi, Xiangyang; Li, Zhonggen; Yu, Genhua

    2013-10-01

    In the present study, magnetic measurements were combined with geochemical analysis and stable Pb isotopic ratios to reveal the distribution and origination of trace metal pollutants in kindergarten dusts from a typical urban environment of Wuhan, central China. The geoaccumulation index (Igeo) of magnetic properties was more prominent than those of individual metals. The magnetic susceptibility (MS) and trace metals (Zn, Pb, and Cu) in this study together with published results from other Chinese cities formed a liner relationship, suggesting that metal contaminants in Chinese urban areas had similar MS to metal ratios, which could be used as an indicator for identification of pollution sources between Chinese cities and the other Asian cities. Stable Pb isotopic ratios (1.1125-1.1734 for 206Pb/207Pb and 2.4457-2.4679 for 208Pb/207Pb) in the urban dusts from Wuhan were characterized by higher 208Pb component in comparison with those from other Chinese cities. This result combined with principal component analysis (PCA) indicated that metal pollutants in the dusts were derived from industrial activities and coal combustion, whereas the traffic emissions were no longer a predominant pollution source in urban environment. Our study demonstrated that environmental magnetic methods could not only reveal the overall situation of trace metal contamination, but also prove evidence in the identification of pollution sources.

  16. Enhanced diffusion of Uranium and Thorium linked to crystal plasticity in zircon

    Reddy Steven M

    2006-12-01

    Full Text Available Abstract The effects of crystal-plasticity on the U-Th-Pb system in zircon is studied by quantitative microstructural and microchemical analysis of a large zircon grain collected from pyroxenite of the Lewisian Complex, Scotland. Electron backscatter diffraction (EBSD mapping reveals a c.18° variation in crystallographic orientation that comprises both a gradual change in orientation and a series of discrete low-angle (207Pb/206Pb ages for individual analyses show no significant variation across the grain, and define a concordant, combined mean age of 2451 ± 14 Ma. This indicates that the grain was deformed shortly after initial crystallization, most probably during retrograde Inverian metamorphism at amphibolite facies conditions. The elevated Th over U and consistent 207Pb/206Pb ages indicates that deformation most likely occurred in the presence of a late-stage magmatic fluid that drove an increase in the Th/U during deformation. The relative enrichment of Th over U implies that Th/U ratio may not always be a robust indicator of crystallization environment. This study provides the first evidence of deformation-related modification of the U-Th system in zircon and has fundamental implications for the application and interpretation of zircon trace element data.

  17. Characteristics of Heavy Metals and Pb Isotopic Composition in Sediments Collected from the Tributaries in Three Gorges Reservoir, China

    Bo Gao

    2014-01-01

    Full Text Available The concentrations, distribution, accumulation, and potential ecological risk of heavy metals (Cr, Cu, Zn, Ni, As, Pb, Cd, and Hg in sediments from the Three Gorges Reservoir (TGR tributaries were determined and studied. Pb isotopic compositions in sediments were also measured to effectively identify the potential Pb sources. The results showed that the average concentrations of heavy metals in sediment of TGR tributaries were higher than the local background values of soils and sediments in China. The assessment by Geoaccumulation Index indicated that Cu, Ni, and Hg were at the “slightly polluted” level and Cd was ranked as the “moderately polluted” level in tributary sediments of TGR. The assessment by Potential Ecological Risk Index showed that Hg and Cd were the predominant elements in tributary sediments in TGR. The Pb isotopic ratios in sediments varied from 1.171 to 1.202 for 206Pb/207Pb and from 2.459 to 2.482 for 208Pb/207Pb in TGR. All Pb isotopic ratios in sediments were similar to those from coal combustion, lead ores (the mining activities and smelting process, and cement material, indicating that these anthropogenic inputs may be the main sources for Pb pollution in sediments of TGR tributaries.

  18. Study of Particle Production and Nuclear Fragmentation in Relativistic Heavy-Ion Collisions in Nuclear Emulsions

    2002-01-01

    % EMU11 \\\\ \\\\ We propose to use nuclear emulsions for the study of nuclear collisions of $^{207}$Pb, $^{197}$Au, and any other heavy-ion beams when they are available. We have, in the past, used $^{32}$S at 200A~GeV and $^{16}$O at 200A and 60A~GeV from CERN (Experiment EMU08) and at present the analysis is going on with $^{28}$Si beam from BNL at 14.5A~GeV. It will be important to compare the previous and the present investigations with the new $^{207}$Pb beam at 60-160A~GeV. We want to measure in nuclear emulsion, on an event by event basis, shower particle multiplicity, pseudorapidity density and density fluctuations of charged particles, charge multiplicity and angular distributions of projectile fragments, production and interaction cross-sections of heavily ionizing particles emitted from the target fragmentation. Special emphasis will be placed on the analysis of events produced in the central collisions which are selected on the basis of low energy fragments emitted from the target excitation. It woul...

  19. 40Ar/39Ar and U-Th-Pb dating of separated clasts from the Abee E4 chondrite

    Bogard, D.D.; Unruh, D.M.; Tatsumoto, M.

    1983-01-01

    Determinations of 40Ar/39Ar and U-Th-Pb are reported for three clasts from the Abee (E4) enstatite chondrite, which has been the object of extensive consortium investigations. The clasts give 40Ar/39Ar plateau ages and/or maximum ages of 4.5 Gy, whereas two of the clasts give average ages of 4.4 Gy. Within the range of 4.4-4.5 Gy these data do not resolve any possible age differences among the three clasts. 206Pb measured in these clasts is only ???1.5-2.5% radiogenic, which leads to relatively large uncertainties in the Pb isochron age and in the 207Pb/206Pb model ages. The Pb data indicate that the initial 207Pb/206Pb was no more than 0.08??0.07% higher than this ratio in Can??on Diablo troilite. The U-Th-Pb data are consistent with the interpretation that initial formation of these clasts occurred 4.58 Gy ago and that the clasts have since remained closed systems, but are contaminated with terrestrial Pb. The 40Ar/39Ar ages could be gas retention ages after clast formation or impact degassing ages. The thermal history of Abee deduced from Ar data appears consistent with that deduced from magnetic data, and suggests that various Abee components experienced separate histories until brecciation no later than 4.4 Gy ago, and experienced no appreciable subsequent heating. ?? 1983.

  20. A study of radionuclides, metals and stable lead isotope ratios in sediments and soils in the vicinity of natural U-mineralisation areas in the Northern Territory

    Frostick, A., E-mail: Alison.Frostick@cdu.edu.au [Charles Darwin University, School of Environment and Life Sciences, Darwin NT 0909 (Australia); ERISS, GPO Box 461, Darwin NT 0801 (Australia); Bollhoefer, A. [ERISS, GPO Box 461, Darwin NT 0801 (Australia); Parry, D. [AIMS, PO Box 41775, Casuarina NT 0811 (Australia)

    2011-10-15

    Australian guidelines recommend that tailings materials from uranium (U) mining and milling be contained without any detrimental impact on the environment for at least 1000 years. Natural analogue sites are being investigated to determine if they can provide data on the rates of natural erosion processes which occur over these timescales, for input into predictive geomorphic computer models. This paper presents radionuclide, metal and stable lead (Pb) isotope data from sediment cores and surface soils in the vicinity of two mineralised areas in the Alligator Rivers Region. Surface scrapes from the natural Anomaly no. 2, south of the Ranger mineral lease, exhibit radiogenic {sup 206}Pb/{sup 207}Pb and {sup 208}Pb/{sup 207}Pb ratios, and elevated U and metal concentrations typical for a near surface U anomaly. In contrast, samples taken from the Koongarra mineral lease (KML) show radionuclide activity and metal concentrations similar to natural areas elsewhere in the Alligator Rivers Region and Pb isotope ratios are closer to present day average crustal ratios (PDAC), as the orebodies at KML are covered by surficial sand. A sediment core collected from Anbangbang Billabong, downstream of KML, exhibits small variations in Pb isotope ratios that indicate that approximately 1% of the upper sediments in the sediment core may be derived from material originating from the U anomaly at Koongarra.

  1. Pb Isotope Compositions of Shibaqinghao Gold Deposit in Central Inner Mongolia, China

    ZHANG Hongying; LIANG Yibo

    2002-01-01

    There are two types of gold ore in Shibaqinghao gold deposit, a mylonite ore and a quartz - vein ore. Pb isotope compositions for mylonite ore are characterized by lower Pb isotope ratios ranging from 16.63 to 17.45 (206Pb/204Pb), 15.31 to15.48 (207Pb/204pb), 36.52 to 38.85 (208Pb/204Pb). They are scattered very close to a model curve of the mantle evolution. These ratios suggest that gold in the mylonite ore might be derived from the country rocks, which originated directly in the upper mantle. Pb isotope compositions for quartz - vein ore are characterized by higher Pb isotope ratios ranging from 18.23 to 19.74 (206Pb/204Pb), 15.69 to 15.89 (207Pb/204Pb), 38.64 to 40. 13 (208Pb/204Pb). They are scattered very close to a model curve of the upper crustal evolution. These facts indicate that the gold in the quartz - vein ore might be related to some granitic magma generated in the crust.

  2. Influence of agricultural practice on trace metals in soils and vegetation in the water conservation area along the East River (Dongjiang River), South China

    Luo, Chunling, E-mail: clluo@gig.ac.cn [Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640 (China); Yang, Renxiu [Department of Civil and Structural Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon (Hong Kong); Wang, Yan; Li, Jun; Zhang, Gan [Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640 (China); Li, Xiangdong [Department of Civil and Structural Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon (Hong Kong)

    2012-08-01

    Dongjiang (East River) is the key resource of potable water for the Pearl River Delta region, South China. Although industrial activities are limited in the water conservation area along this river, agriculture is very intensive. The present study evaluated trace metals in four soils under different cultivation. The total concentrations of trace metals decreased in the order orchard soil > vegetable soil > paddy soil > natural soil, reflecting decreasing inputs of agrochemicals to soils. Relatively high concentrations of Cd were recorded in the 60-cm soil profiles. The {sup 206}Pb/{sup 207}Pb ratio in the above-ground tissues of plant was significantly lower than their corresponding soils. In combination with the low transfer factor of Pb from soil to plant shoots, atmospheric deposition is probably a major pathway for Pb to enter plant leaves. Regular monitoring on the soil quality in this area is recommended for the safety of water resource and agricultural products. - Highlights: Black-Right-Pointing-Pointer Soil Cd exceeded the upper limit of Chinese standard for agricultural soils. Black-Right-Pointing-Pointer Relatively high concentrations of Cd were recorded in the 60-cm soil profiles. Black-Right-Pointing-Pointer Agricultural soil had higher concentrations of metals and lower {sup 206}Pb/{sup 207}Pb ratios. Black-Right-Pointing-Pointer Pb in above-ground tissues of plant was more anthropogenic than soil. Black-Right-Pointing-Pointer Atmospheric deposition may be a major pathway for Pb to enter plant leaves.

  3. Spatial distribution, health risk assessment, and isotopic composition of lead contamination of street dusts in different functional areas of Beijing, China.

    Han, Lanfang; Gao, Bo; Wei, Xin; Xu, Dongyu; Gao, Li

    2016-02-01

    Street dusts from heavy density traffic area (HDTA), tourism area (TA), residential area (RA), and educational area (EA) in Beijing were collected to explore the distribution, health risk assessment, and source of lead (Pb). The average concentration of Pb in TA was the highest among the four areas. Compared with other cities, Pb concentrations in Beijing were generally at moderate or low levels. The average value (14.05) of ecological risk index (RI) indicated that Pb was at "low pollution risk" status. According to the calculation on hazard index (HI), the ingestion of dust particles of children and adults was the major route of exposure to street dusts in four studied areas, followed by dermal contact. The lower values of HI than 1 further suggested that non-carcinogenic risks of Pb in the street dusts were in the low range. Comparing (206)Pb/(207)Pb and (208)Pb/(207)Pb ratios of street dusts with other environmental samples, it was found that atmospheric deposition of coal combustion dust might be the main pathway for anthropogenic Pb input to the street dusts in four functional areas.

  4. A new method for stable lead isotope extraction from seawater

    Zurbrick, Cheryl M., E-mail: CZurbric@ucsc.edu [WIGS, Department of Microbiology and Environmental Toxicology, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 (United States); Gallon, Céline [Institute of Marine Sciences, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 (United States); Flegal, A. Russell [WIGS, Department of Microbiology and Environmental Toxicology, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 (United States); Institute of Marine Sciences, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 (United States)

    2013-10-24

    Graphical abstract: -- Highlights: •We present a relatively fast (2.5–6.5 h), semi-automated system to extract Pb from seawater. •Extraction requires few chemicals and has a relatively low blank (0.7 pmol kg{sup −1}). •We compare analyses of Pb isotopes by HR ICP-MS with those by MC-ICP-MS. -- Abstract: A new technique for stable lead (Pb) isotope extraction from seawater is established using Toyopearl AF-Chelate 650 M{sup ®} resin (Tosoh Bioscience LLC). This new method is advantageous because it is semi-automated and relatively fast; in addition it introduces a relatively low blank by minimizing the volume of chemicals used in the extraction. Subsequent analyses by HR ICP-MS have a good relative external precision (2σ) of 3.5‰ for {sup 206}Pb/{sup 207}Pb, while analyses by MC-ICP-MS have a better relative external precision of 0.6‰. However, Pb sample concentrations limit MC-ICP-MS analyses to {sup 206}Pb, {sup 207}Pb, and {sup 208}Pb. The method was validated by processing the common Pb isotope reference material NIST SRM-981 and several GEOTRACES intercalibration samples, followed by analyses by HR ICP-MS, all of which showed good agreement with previously reported values.

  5. Holocene elemental, lead isotope and charcoal record from peat in southern Poland

    K. Tudyka

    2017-03-01

    Full Text Available This article presents a mid-resolution elemental, isotopic and charcoal record from 10700 BC to AD 500 in a peat core located in Żyglin (southern Poland. The objective is to give insight into the proxies with emphasis on lead (Pb sources in this minerogenic peat deposit. During the Early Holocene (10700–7550 BC the average 206Pb/207Pb quotient was around 1.196. This isotopic signature is consistent with natural dust derived from long-distance soil and rock weathering. The Mid-Holocene period (7550–3200 BC shows a significant change in the peat accumulation conditions. The growth rate is approximately 0.04 mm yr-1 and the 206Pb/207Pb quotients are shifted toward values that are found in local galena ores. This is simultaneous with a significantly increased lead flux which further confirms local sources of material in this peat deposit. In the Late Holocene period (3200 BC–AD 500 a large quantity of charcoal particles with diameters ranging from 2 mm up to 3 cm is found; also, Pb, Zn and Cu fluxes reach their highest values. This period corresponds to the Eneolithic, Bronze and Iron Ages, and human impact is recorded as charcoal.

  6. Assessment of pollution aerosols sources above the Straits of Dover using lead isotope geochemistry.

    Deboudt, K; Flament, P; Weis, D; Mennessier, J P; Maquinghen, P

    1999-09-15

    We assess the capability of lead isotopes to study the transport of pollution aerosols above the Straits of Dover by collecting atmospheric aerosols above the Eastern Channel and the Southern Bight of the North Sea. During the same period, we characterized the lead isotopic signature of the main industrial sources on the French coast near the Straits of Dover. Urban and automobile-derived aerosols were also collected. Due to the phasing out of lead in gasoline, the urban isotopic composition (206Pb/207Pb = 1.158 +/- 0.003) has become more radiogenic, although it is highly variable. On a regional scale, major industrial emissions have a well-defined isotopic composition (1.13 isotopic compositions, it can be shown that lead aerosols originating from eastern Europe have an isotopic signature (1.145 isotopic composition of west-European lead aerosols (1.111 < 206Pb/207Pb < 1.142). The influence of remote North American sources is suggested, with caution, due to uncertainties in meteorological calculations.

  7. Characteristics of lead geochemistry and the mobility of Pb isotopes in the system of pedogenic rock-pedosphere-irrigated riverwater-cereal-atmosphere from the Yangtze River delta region, China.

    Wang, Cheng; Wang, Jianhua; Yang, Zhongfang; Mao, Changping; Ji, Junfeng

    2013-11-01

    Knowledge of the characteristics of Pb and its isotopic transfer in different compartments is scant, especially for the mobility of Pb isotopes in the geochemical cycle. The present study characterizes differential Pb transport mechanism and the mobility of Pb isotopes in the pedogenic parent rock-pedosphere-irrigated riverwater-cereal-atmosphere system in the Yangtze River delta region, by determining Pb concentration and Pb isotopic ratios of pedogenic parent rocks, fluvial suspended particle matter, tillage soils, soil profiles, irrigated riverwater, fertilizer, Pb ore, cereal roots and grains. The results show that Pb isotopes in the geochemical cycle generally follow the equation of (208)Pb/(206)Pb=-1.157×(206)Pb/(207)Pb+3.46 (r(2)=0.941). However, Pb isotopes have different mobility in different environmental matrixes. Whereas in the pedosphere, the heavier Pb ((208)Pb) usually shows stronger mobility relative to the lighter Pb, and is more likely to transfer into soil exchangeable Pb fraction and carbonates phase. The lighter Pb shows stronger transfer ability from soil to cereal grain via root compared to the heavier Pb. However, the cereal grains have lower (206)Pb/(207)Pb and higher (208)Pb/(206)Pb ratios than root and tillage soil, similar to the airborne Pb and anthropogenic Pb, implying that a considerable amount of Pb in cereal grains comes from the atmosphere. The estimate model shows that 16.7-52.6% (average: 33.5%) of Pb in rice grain is the airborne Pb.

  8. Pb isotopes as tracers of mining-related Pb in lichens, seaweed and mussels near a former Pb-Zn mine in West Greenland

    Søndergaard, Jens; Asmund, Gert; Johansen, Poul;

    2010-01-01

    Identification of mining-related contaminants is important in order to assess the spreading of contaminants from mining as well as for site remediation purposes. This study focuses on lead (Pb) contamination in biota near the abandoned ‘Black Angel Mine’ in West Greenland in the period 1988......–2008. Stable Pb isotope ratios and total Pb concentrations were determined in lichens, seaweed and mussels as well as in marine sediments. The results show that natural background Pb (207Pb/206Pb: 0.704–0.767) and Pb originating from the mine ore (207Pb/206Pb: 0.955) have distinct isotopic fingerprints. Total...... Pb in lichens, seaweed, and mussels was measured at values up to 633, 19 and 1536 mg kg-1 dry weight, respectively, and is shown to be a mixture of natural Pb and ore-Pb. This enables quantification of mining-related Pb and shows that application of Pb isotope data is a valuable tool for monitoring...

  9. Lead isotope and trace element composition of urban soils in Mongolia

    Tserenpil, Sh.; Sapkota, A.; Liu, C.-Q.; Peng, J.-H.; Liu, B.; Segebade, P. Chr.

    2016-08-01

    Lead (Pb) pollution in and around Ulaanbaatar is of national concern, given that the Mongolian capital is home to nearly half of the country's entire population. By comparison, Mongolian countryside is a pristine environment because of its sparse population and low industrial activity. The concentration of Pb in urban soils (average of 39.1 mg kg-1) was twice the values found (average 18.6 mg kg-1) in background territories (i.e., Mongolian rural sites). Furthermore, Pb contamination was examined by using Pb stable isotopic composition, and covariance of Pb isotopic ratios showed two groups between rural and urban soils as pristine and disturbed sites. The 206Pb/207Pb ratio, the most prominent fingerprint for Pb pollution, was 1.163-1.185 for the urban whereas values for rural soils (1.186-1.207) were analogue to the regional Pb isotopic signatures. Local coal sources and their combustion products, one of the potential Pb pollution sources in Ulaanbaatar, have significant radiogenic properties in terms of Pb isotopic composition and revealed an average of 1.25 for 206Pb/207Pb and 19.551 for 206Pb/204Pb ratios. Thus, contributions from coal firing activity to Pb pollution lower than it was assumed, and smaller range of these values measured in urban soils may be attributed to the mixing of less radiogenic Pb as a constituent of the leaded gasolines.

  10. Estimation of lead sources in a Japanese cedar ecosystem using stable isotope analysis

    Itoh, Yuko [Forestry and Forest Products Research Institute, Matsunosato 1, Tsukuba, Ibaraki 305-8687 (Japan)]. E-mail: yuko106@ffpri.affrc.go.jp; Noguchi, Kyotaro [Forestry and Forest Products Research Institute, Matsunosato 1, Tsukuba, Ibaraki 305-8687 (Japan); Takahashi, Masamichi [Forestry and Forest Products Research Institute, Matsunosato 1, Tsukuba, Ibaraki 305-8687 (Japan); Okamoto, Toru [Forestry and Forest Products Research Institute, Matsunosato 1, Tsukuba, Ibaraki 305-8687 (Japan); Yoshinaga, Shuichiro [Forestry and Forest Products Research Institute, Matsunosato 1, Tsukuba, Ibaraki 305-8687 (Japan)

    2007-06-15

    Anthropogenic Pb affects the environment worldwide. To understand its effect on forest ecosystem, Pb isotope ratios were determined in precipitation, various components of vegetation, the forest floor, soil and parent material in a Japanese cedar (Cryptomeria japonica D. Don) forest stand. The average {sup 206}Pb/{sup 207}Pb ratio in bulk precipitation was 1.14 {+-} 0.01 (mean {+-} SD), whereas that in the subsoil (20-130 cm) was 1.18 {+-} 0.01. Intermediate ratios ranging from 1.15 to 1.16 were observed in the vegetation, the forest floor, and the surface soil (0-10 cm). Using the {sup 206}Pb/{sup 207}Pb ratios, the contribution of anthropogenic sources to Pb accumulated in the forest were estimated by the simple binary mixing model. Sixty-two percent of the Pb in the forest floor, 71% in the vegetation, and 55% in the surface soil (0-10 cm) originated from anthropogenic sources, but only 16% in the sub-surface soil (10-20 cm) was anthropogenic. These results suggest that internal Pb cycling occurs mainly between surface soil and vegetation in a Japanese cedar ecosystem, and that anthropogenic Pb strongly influences Pb cycling. Although the Japanese cedar ecosystem has a shallow forest floor, very little atmospherically derived Pb migrated downward over 10 cm in depth.

  11. In-situ trace element analyses and Pb-Pb dating of zircons in granulite from Huangtuling, Dabieshan by LAM-ICP-MS

    吴元保; 陈道公; 夏群科; 涂湘林; 程昊; 杨晓志

    2003-01-01

    It is revealed by CL images that there are multi-stage growth internal structures of zircons in the Huangtuling granulite, including the inherited zircons, protolith zircons, sector and planar zone zircons and retrograde zircons. In-situ trace element compositions and Pb-Pb ages have been analyzed by LAM-ICP-MS. The sector and the planar zone domains show typical trace element characteristics of granulite zircon (low Th, U, Th/U, total REEs, clear negative Eu anomalies, relatively depleted HREE and small differential degree between MREE and HREE, etc.), indicating that they formed during granulite-facies metamorphism. The protolith zircons have trace element characteristics of crustal zircon (high Th, U, Th/U, total REEs and enriched HREEs, etc.). 12 analyzed spots on granulite-facies domains give a weighted mean 207Pb/206Pb age of (2154±26) Ma (MSWD = 3.8), which is the best estimated age of granulite-facies metamorphism of this sample. The weighted mean 207Pb/206Pb age of 5 analyzed spots on protolith zircon domains is (2714 ± 22) Ma (MSWD = 1.4), which represents the protolith forming time. The discovery of ca. 3.4 Ga inherited zircon indicates that there are Palaeoarchean continental materials in this area. The interpretation of formation conditions and the ages of zircons can be constrained by simultaneous in-situ analysis of trace elements and ages.

  12. Electronic Inhomogeneity in PbTe-based High Performance Thermoelectric Materials Observed by NMR

    Levin, E. M.; Schmidt-Rohr, K.; Cook, B. A.; Kanatzidis, M. G.

    2009-03-01

    Effects of composition and synthesis conditions on the local structure and charge carrier concentration in AgxSbyPb18Te20 (LAST-18) thermoelectric (TE) materials have been studied by ^125Te and ^207Pb nuclear magnetic resonance (NMR) with magic-angle spinning. The high-resolution ^125Te NMR spectra show that most Sb and Ag is not part of Sb2Te3, AgSbTe2, or Ag2Te inclusions. Biexponential NMR spin-lattice (T1) relaxation as well as Knight shifts of ^125Te and ^207Pb NMR signals show that many LAST-18 materials contain two phases of similar composition but with free electron concentrations that differ by more than an order of magnitude, i.e. these materials are electronically inhomogeneous. The NMR data were calibrated against Hall- and Seebeck-effect measurements to give the charge carrier concentrations in the two phases. This electronic inhomogeneity may result in the appearance of potential barriers inside TE materials, similar to those observed for semiconductor-semiconductor or metal-semiconductor junctions. Such barriers may affect thermopower, electrical, and thermal conductivity of TE materials.

  13. Lead and strontium isotopic evidence for crustal interaction and compositional zonation in the source regions of Pleistocene basaltic and rhyolitic magmas of the Coso volcanic field, California

    Bacon, C.R.; Kurasawa, H.; Delevaux, M.H.; Kistler, R.W.; Doe, B.R.

    1984-01-01

    The isotopic compositions of Pb and Sr in Pleistocene basalt, high-silica rhyolite, and andesitic inclusions in rhyolite of the Coso volcanic field indicate that these rocks were derived from different levels of compositionally zoned magmatic systems. The 2 earliest rhyolites probably were tapped from short-lived silicic reservoirs, in contrast to the other 36 rhyolite domes and lava flows which the isotopic data suggest may have been leaked from the top of a single, long-lived magmatic system. Most Coso basalts show isotopic, geochemical, and mineralogic evidence of interaction with crustal rocks, but one analyzed flow has isotopic ratios that may represent mantle values (87Sr/86Sr=0.7036,206Pb/204Pb=19.05,207Pb/204Pb=15.62,208Pb/204Pb= 38.63). The (initial) isotopic composition of typical rhyolite (87Sr/86Sr=0.7053,206Pb/204Pb=19.29,207Pb/204Pb= 15.68,208Pb/204Pb=39.00) is representative of the middle or upper crust. Andesitic inclusions in the rhyolites are evidently samples of hybrid magmas from the silicic/mafic interface in vertically zoned magma reservoirs. Silicic end-member compositions inferred for these mixed magmas, however, are not those of erupted rhyolite but reflect the zonation within the silicic part of the magma reservoir. The compositional contrast at the interface between mafic and silicic parts of these systems apparently was greater for the earlier, smaller reservoirs. ?? 1984 Springer-Verlag.

  14. Analogue studies in the alligator rivers region. In-situ measurement of uranium series nuclides with SHRIMP

    Nagano, Tetsushi; Yanase, Nobuyuki; Ohnuki, Toshihiko [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Sato, Tsutomu; Isobe, Hiroshi; Williams, I.S.; Zaw, M.; Payne, T.E.; Airey, P.L.

    1999-03-01

    The SHRIMP analyses have been conducted for rock samples from the Koongarra secondary ore deposit to obtain activity ratios of {sup 234}U/{sup 238}U and isotopic ratios of {sup 207}Pb/{sup 206}Pb and {sup 204}Pb/{sup 206}Pb. Target minerals for the analyses were iron minerals and kaolinite, which are the main weathering products in this area. The activity ratios of {sup 234}U/{sup 238}U were obtained based on counts at masses of uranium metal. The {sup 234}U/{sup 238}U activity ratios based on counts of uranium oxides were not appropriate, because count rates of {sup 234}U{sup 16}O were interfered by those of {sup 238}U{sup 12}C molecule. The activity ratios of {sup 234}U/{sup 238}U were approximately unity for crystalline iron nodules. This fact suggested that the mean residence time of uranium within the iron nodules was at least 1 million years. On the other hand, slightly higher values than unity were obtained for kaolinite. Lead isotopes were investigated and a positive relationship was recognized between {sup 207}Pb/{sup 206}Pb and {sup 204}Pb/{sup 206}Pb isotope ratios. (author)

  15. A propene-substituted cyclotriphosphazene : Synthesis, characterization and polymerization

    Bosscher, G; Meetsma, A; vandeGrampel, JC

    1997-01-01

    The elimination reaction of the sulfonium-substituted chlorocyclotriphosphazene N3P3Cl4Pri(CMe2OSO2Me) with 1,8-diazabicyclo[5.4.0]undec-7-ene afforded a new olefin-substituted chlorocyclotriphosphazene, N3P3Cl4Pri(CMe=CH2), and an ansa derivative with formula N3P3Cl3Pri(CMe2CH=CMeO). The crystal st

  16. Arterijska hipertenzija in DASH dieta

    Vidović, Duška

    2017-01-01

    Uvod: Arterijska hipertenzija je pri nas in v razvitem svetu poglavitni vzrok obolevnosti in umrljivosti, zato predstavlja velik javno-zdravstveni problem. Namen: Namen diplomskega dela je na teoretični ravni predstaviti arterijsko hipertenzijo, dejavnike tveganja za nastanek arterijske hipertenzije in zdravljenje s poudarkom na predstavitvi DASH diete, ki je oblika pravilnega prehranjevanja pri obolenju oseb z visokim krvnim tlakom. Diplomsko delo želi predstaviti vlogo medicinske sestre pri...

  17. Mitigating Corruption in Government Security Forces: The Role of Institutions, Incentives, and Personnel Management in Mexico

    2011-01-01

    Preventive Police PJF Policía Judicial Federal, or Federal Judicial Police PRI Partido Revolucionario Institucional , or Institutional Revolutionary...Partido Revolucionario Institucional , or PRI) emerged as the dominating political force in Mexico in the 20th century. The PRI regime was... tradicional /default.aspx Jacob, Brian A., and Steven D. Levitt, “Rotten Apples: An Investigation of the Prevalence and Predictors of Teacher Cheating

  18. Remedial sanation arthroscopy in gouty arthropathy of the knee joint

    V V Lyalina

    2007-01-01

    Zaklyuchenie. Predlozhennaya avtorami metodika sanatsionnoy artroskopii znachitel'no rasshiryaet spektr lechebnykh vozmozhnostey i pozvolyaet optimizirovat' lechebnuyu taktiku pri khronicheskom podagricheskom artrite kolennogo sustava.

  19. GOVORNE NAPAKE PREDŠOLSKIH OTRKO IN SODELOVANJE LOGOPEDA IN VZGOJITELJA V VRTCU

    Praznik, Stanislava

    2013-01-01

    Diplomsko delo opisuje govorne napake pri predšolskih otrocih in sodelovanje vzgojiteljice in logopeda v vrtcu in sodelovanje vzgojiteljice in logopeda, ki ne dela v vrtcu. V teoretičnem delu je najprej opisan razvoj govora in faze govornega razvoja, govorne napake, delo logopeda in teorije o učenju govora, pomoč in vaje pri učenju govora in vloga odraslega pri učenju govora. Zavedati se moramo, da je govor prvo komunikacijsko sredstvo, ki ga uporabljamo. Pomoč vzgojiteljice pri razvoju go...

  20. Program Energy of the CNRS. Topic 10 combustion and capture of CO{sub 2}. PRI 10.1. Capture by adsorption of the CO{sub 2} in thermal power plants gas and their injection in petroleum wells. Final report period 2002-2004; Programme energie du CNRS. Theme 10 combustion et capture du CO2. PRI 10.1. Capture par adsorption du CO2 dans des gaz de centrales thermiques et leur injection en puits de petrole. Rapport final periode 2002-2004

    Tondeur, D

    2005-07-01

    In the framework of the global warming resulting of the greenhouse gases emission increase, the carbon dioxide capture and storage in deep underground cavities of old petroleum and gas deposits, are studied. This report presents the researches realized by the CNRS (France) in the domain: technology and knowledge assessment concerning the carbon dioxide capture and storage, active coals for the CO{sub 2} capture, methodology of thermo-economical optimization of the combined cycle, global simulation of an IGCC (Integrated gasification combined cycle) with CO{sub 2} capture and integration in the process scheme, petroleum recovery-aided by CO{sub 2} injection, storage in geological deposits. (A.L.B.)

  1. GenBank blastx search result: AK060171 [KOME

    Full Text Available 1 (splicing factor 2, alternate splicing factor), mRNA (cDNA clone MGC:5228 IMAGE:2900101), complete cds.|PRI PRI 2e-14 +1 ... ...AK060171 006-311-F07 BC010264.1 Homo sapiens splicing factor, arginine/serine-rich

  2. GenBank blastx search result: AK061903 [KOME

    Full Text Available 1 (splicing factor 2, alternate splicing factor), mRNA (cDNA clone MGC:45185 IMAGE:5166554), complete cds.|PRI PRI 6e-47 +1 ... ...AK061903 001-041-H07 BC033785.1 Homo sapiens splicing factor, arginine/serine-rich

  3. GenBank blastx search result: AK060171 [KOME

    Full Text Available 1 (splicing factor 2, alternate splicing factor), mRNA (cDNA clone MGC:45185 IMAGE:5166554), complete cds.|PRI PRI 2e-14 +1 ... ...AK060171 006-311-F07 BC033785.1 Homo sapiens splicing factor, arginine/serine-rich

  4. GenBank blastx search result: AK106998 [KOME

    Full Text Available AK106998 002-120-B12 AB179082.1 Macaca fascicularis testis cDNA clone: QtsA-12630, similar to human oculocer...ebrorenal syndrome of Lowe (OCRL), transcriptvariant a, mRNA, RefSeq: NM_000276.3.|PRI PRI 1e-29 +3 ...

  5. GenBank blastx search result: AK061708 [KOME

    Full Text Available AK061708 001-037-F11 AF023268.1 Homo sapiens clk2 kinase (CLK2), propin1, cote1, glucocerebro...sidase (GBA), and metaxin genes, complete cds; metaxin pseudogene and glucocerebrosidase pseudogene; and thrombospondin3 (THBS3) gene, partial cds.|PRI PRI 1e-41 +3 ...

  6. GenBank blastx search result: AK104229 [KOME

    Full Text Available AK104229 006-307-D03 AF023268.1 Homo sapiens clk2 kinase (CLK2), propin1, cote1, glucocerebro...sidase (GBA), and metaxin genes, complete cds; metaxin pseudogene and glucocerebrosidase pseudogene; and thrombospondin3 (THBS3) gene, partial cds.|PRI PRI 3e-41 +3 ...

  7. GenBank blastx search result: AK059494 [KOME

    Full Text Available AK059494 001-028-H05 AB179082.1 Macaca fascicularis testis cDNA clone: QtsA-12630, similar to human oculocer...ebrorenal syndrome of Lowe (OCRL), transcriptvariant a, mRNA, RefSeq: NM_000276.3.|PRI PRI 7e-40 +2 ...

  8. GenBank blastx search result: AK058642 [KOME

    Full Text Available AK058642 001-018-E05 AF023268.1 Homo sapiens clk2 kinase (CLK2), propin1, cote1, glucocerebro...sidase (GBA), and metaxin genes, complete cds; metaxin pseudogene and glucocerebrosidase pseudogene; and thrombospondin3 (THBS3) gene, partial cds.|PRI PRI 2e-18 +3 ...

  9. GenBank blastx search result: AK060447 [KOME

    Full Text Available AK060447 001-011-F08 AY163769.1 Homo sapiens excision repair cross-complementing ro...dent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) (ERCC3) gene, complete cds.|PRI PRI 1e-155 +1 ...

  10. GenBank blastx search result: AK060447 [KOME

    Full Text Available AK060447 001-011-F08 BC008820.2 Homo sapiens excision repair cross-complementing ro...dent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing), mRNA (cDNA clone MGC:10371 IMAGE:3958781), complete cds.|PRI PRI 1e-155 +1 ...

  11. GenBank blastx search result: AK104850 [KOME

    Full Text Available AK104850 001-043-A07 AY204752.1 Homo sapiens excision repair cross-complementing ro...dent repair deficiency, complementation group 6 (ERCC6) gene, complete cds.|PRI PRI 1e-12 +3 ...

  12. GenBank blastx search result: AK104850 [KOME

    Full Text Available AK104850 001-043-A07 AB209504.1 Homo sapiens mRNA for excision repair cross-complement...ing rodent repair deficiency, complementation group 6 variant protein.|PRI PRI 1e-12 +3 ...

  13. GenBank blastx search result: AK060447 [KOME

    Full Text Available AK060447 001-011-F08 AK222465.1 Homo sapiens mRNA for excision repair cross-complement...ing rodent repair deficiency, complementation group 3 variant, clone: adKA02463.|PRI PRI 1e-153 +1 ...

  14. Comparative effects of partial root-zone irrigation and deficit irrigation on phosphorus uptake in tomato plants

    Wang, Yaosheng; Liu, Fulai; Jensen, Christian Richardt

    2012-01-01

    The comparative effects of partial root-zone irrigation (PRI) and deficit irrigation (DI) on phosphorus (P) uptake in tomato (Lycopersicon esculentum Mill.) plants were investigated in a split-root pot experiment. The results showed that PRI treatment improved water-use efficiency (WUE) compared...

  15. GenBank blastx search result: AK107538 [KOME

    Full Text Available some 10 Contains a novel gene, the HPS1 gene for Hermansky-Pudlak syndrome 1, the 3' end of the HPSE2 gene for heparanase 2 and a CpG island, complete sequence.|PRI PRI 5e-21 +2 ...

  16. GenBank blastx search result: AK063915 [KOME

    Full Text Available some 10 Contains a novel gene, the HPS1 gene for Hermansky-Pudlak syndrome 1, the 3' end of the HPSE2 gene for heparanase 2 and a CpG island, complete sequence.|PRI PRI 1e-139 +3 ...

  17. GenBank blastx search result: AK060767 [KOME

    Full Text Available some 10 Contains a novel gene, the HPS1 gene for Hermansky-Pudlak syndrome 1, the 3' end of the HPSE2 gene for heparanase 2 and a CpG island, complete sequence.|PRI PRI 3e-25 +2 ...

  18. GenBank blastx search result: AK058594 [KOME

    Full Text Available AK058594 001-017-H01 AB169480.1 Macaca fascicularis testis cDNA, clone: QtsA-21542, similar to human diaphor...ase (NADH) (cytochrome b-5 reductase) (DIA1),transcript variant M, mRNA, RefSeq: NM_000398.3.|PRI PRI 7e-53 +3 ...

  19. GenBank blastx search result: AK103964 [KOME

    Full Text Available AK103964 001-015-F12 AB169480.1 Macaca fascicularis testis cDNA, clone: QtsA-21542, similar to human diaphor...ase (NADH) (cytochrome b-5 reductase) (DIA1),transcript variant M, mRNA, RefSeq: NM_000398.3.|PRI PRI 7e-53 +3 ...

  20. GenBank blastx search result: AK106074 [KOME

    Full Text Available AK106074 001-206-H10 BC021102.1 Homo sapiens likely ortholog of mouse immediate early response, erythropoiet...in 4, mRNA (cDNA clone MGC:31837 IMAGE:5020890), complete cds.|PRI PRI 4e-52 +2 ...

  1. GenBank blastx search result: AK061903 [KOME

    Full Text Available ernate splicing factor), mRNA (cDNA clone MGC:5228 IMAGE:2900101), complete cds.|PRI PRI 6e-47 +1 ... ...AK061903 001-041-H07 BC010264.1 Homo sapiens splicing factor, arginine/serine-rich 1 (splicing factor 2, alt

  2. GenBank blastx search result: AK119168 [KOME

    Full Text Available ocyte-activating), mRNA (cDNA clone MGC:20063 IMAGE:3638796), complete cds.|PRI PRI 3e-36 +3 ... ...AK119168 001-036-F11 BC014051.2 Homo sapiens small inducible cytokine subfamily E, member 1 (endothelial mon

  3. GenBank blastx search result: AK108051 [KOME

    Full Text Available ocyte-activating), mRNA (cDNA clone MGC:20063 IMAGE:3638796), complete cds.|PRI PRI 6e-33 +1 ... ...AK108051 002-137-H02 BC014051.2 Homo sapiens small inducible cytokine subfamily E, member 1 (endothelial mon

  4. GenBank blastx search result: AK059433 [KOME

    Full Text Available ocyte-activating), mRNA (cDNA clone MGC:20063 IMAGE:3638796), complete cds.|PRI PRI 3e-15 +1 ... ...AK059433 001-027-F07 BC014051.2 Homo sapiens small inducible cytokine subfamily E, member 1 (endothelial mon

  5. GenBank blastx search result: AK059413 [KOME

    Full Text Available AK059413 001-027-D02 AB063318.1 Homo sapiens MoDP-2, MoDP-3 mRNA for acute morphine... dependence related protein 2, acute morphine dependence related peptide 3, complete cds.|PRI PRI 9e-12 +1 ...

  6. GenBank blastx search result: AK062146 [KOME

    Full Text Available AK062146 001-045-G12 AB063318.1 Homo sapiens MoDP-2, MoDP-3 mRNA for acute morphine... dependence related protein 2, acute morphine dependence related peptide 3, complete cds.|PRI PRI 2e-80 +1 ...

  7. GenBank blastx search result: AK059663 [KOME

    Full Text Available AK059663 001-031-E04 AB063318.1 Homo sapiens MoDP-2, MoDP-3 mRNA for acute morphine... dependence related protein 2, acute morphine dependence related peptide 3, complete cds.|PRI PRI 7e-29 +3 ...

  8. GenBank blastx search result: AK060220 [KOME

    Full Text Available AK060220 001-002-F01 BC065912.1 Homo sapiens v-abl Abelson murine leukemia viral on...cogene homolog 2 (arg, Abelson-related gene), mRNA (cDNA clone MGC:70756 IMAGE:5173213), complete cds.|PRI PRI 1e-37 +3 ...

  9. GenBank blastx search result: AK061938 [KOME

    Full Text Available AK061938 001-042-D07 BC065912.1 Homo sapiens v-abl Abelson murine leukemia viral on...cogene homolog 2 (arg, Abelson-related gene), mRNA (cDNA clone MGC:70756 IMAGE:5173213), complete cds.|PRI PRI 6e-26 +2 ...

  10. GenBank blastx search result: AK111983 [KOME

    Full Text Available AK111983 001-012-H11 BC065912.1 Homo sapiens v-abl Abelson murine leukemia viral on...cogene homolog 2 (arg, Abelson-related gene), mRNA (cDNA clone MGC:70756 IMAGE:5173213), complete cds.|PRI PRI 3e-34 +3 ...

  11. GenBank blastx search result: AK058580 [KOME

    Full Text Available highly similar to DNA-DIRECTED RNA POLYMERASE I 135 KD POLYPEPTIDE (EC 2.7.7.6).|PRI PRI 1e-74 +1 ... ...AK058580 001-017-F06 AK022533.1 Homo sapiens cDNA FLJ12471 fis, clone NT2RM1000894,

  12. GenBank blastx search result: AK110106 [KOME

    Full Text Available AK110106 002-161-A03 AB179164.1 Macaca fascicularis testis cDNA clone: QtsA-14001, similar to human huntingt...in interacting protein 1 (HIP1), mRNA, RefSeq: NM_005338.4.|PRI PRI 2e-51 +1 ...

  13. GenBank blastx search result: AK105069 [KOME

    Full Text Available AK105069 001-045-C01 AB169286.1 Macaca fascicularis testis cDNA, clone: QtsA-18648, similar to human mortali...ty factor 4 like 2 (MORF4L2), mRNA, RefSeq: NM_012286.1.|PRI PRI 3e-20 +3 ...

  14. Internacia Esperanto--Movado

    1996-01-01

    BelgioEn la belga magazino "Knack"(11 okt.1995) aperis 5-paa artikolo de L. Willems pri lamultlingveco de la mondo kaj pri Esperanto.BulgarioLa 14-a sesio de Internacia Somera E-Uni-versitato okazos en Veliko Tarnovo (Bulgario) de

  15. Uvod v tematski sklop

    Florence Gacoin-Marks

    2009-12-01

    Slovenski raziskovalni prostor seveda premore veliko več zanimivih raziskav v zvezi z Afriko, zato lahko samo obžalujemo, da nekateri raziskovalci pri tej publikaciji niso mogli sodelovati in da zato njihova stroka tukaj ni zastopana. Ob tej priložnosti se iskreno zahvaljujem vsem, ki so sodelovali pri projektu s kakovostnimi in raznovrstnimi razpravami.

  16. GenBank blastn search result: AK059159 [KOME

    Full Text Available AK059159 001-023-D03 U91328.1 Human hereditary haemochromatosis region, histone 2A-like protein gene, heredi...tary haemochromatosis (HLA-H) gene, RoRet gene, and sodium phosphate transporter (NPT3) gene, complete cds.|PRI PRI 3e-19 Plus Plus ...

  17. GenBank blastx search result: AK058227 [KOME

    Full Text Available AK058227 001-010-H11 U91328.1 Human hereditary haemochromatosis region, histone 2A-like protein gene, heredi...tary haemochromatosis (HLA-H) gene, RoRet gene, and sodium phosphate transporter (NPT3) gene, complete cds.|PRI PRI 1e-16 +2 ...

  18. GenBank blastn search result: AK059019 [KOME

    Full Text Available AK059019 001-021-B02 U91328.1 Human hereditary haemochromatosis region, histone 2A-like protein gene, heredi...tary haemochromatosis (HLA-H) gene, RoRet gene, and sodium phosphate transporter (NPT3) gene, complete cds.|PRI PRI 5e-47 Plus Minus ...

  19. GenBank blastn search result: AK058741 [KOME

    Full Text Available AK058741 001-019-G08 U91328.1 Human hereditary haemochromatosis region, histone 2A-like protein gene, heredi...tary haemochromatosis (HLA-H) gene, RoRet gene, and sodium phosphate transporter (NPT3) gene, complete cds.|PRI PRI 2e-55 Plus Minus ...

  20. GenBank blastn search result: AK119240 [KOME

    Full Text Available AK119240 001-120-A04 U91328.1 Human hereditary haemochromatosis region, histone 2A-like protein gene, heredi...tary haemochromatosis (HLA-H) gene, RoRet gene, and sodium phosphate transporter (NPT3) gene, complete cds.|PRI PRI 6e-50 Plus Minus ...