WorldWideScience

Sample records for 2008-648 reevaluation dosimetrique

  1. Dosimetric reevaluation of exposure at working stations of the Mafelec Society. Presence on the production site of elevators push-buttons containing cobalt 60 between the 21. august and the 7. october 2008. Amendment to the report DRPH/SDE 2008-648

    International Nuclear Information System (INIS)

    On the 7. october 2008, the public authorities were alerted by the Mafelec society of the detection by their customs services of unusual levels of radioactivity during controls on packages containing elevators push-buttons sent by this society. The first measures made on that very day on the site of the Mafelec society at Chimilin (38) by the mobile cell of radiological intervention of Isere department firemen enlightened the presence of radioactivity in elevators the push-buttons in stainless steel and in complete push-buttons delivered to Mafelec by one or several Indian suppliers. After having made an inspection on the site on the 8. october, the nuclear safety authority requested the help of I.R.S.N. to evaluate the doses received by the facility personnel exposed to these radioactive pieces. The Asn also asked I.R.S.N. to evaluate the public exposure if someone used an elevator equipped with such buttons. The first evaluations showed that 22 persons had received a maximal dose between 1.4 and 2.7 mSv. A second report (on the 27 october 2008) gave a revaluation of the dosimetry. The conclusions were: with the information known at the date of 22 october 2008, it can estimated that only one person received between the 21. august and the 7. october a maximal efficient dose superior to 1 mSv that is the annual limit regulatory value for the public. The details of the revaluation are given and the results are as follow: 1 person received at the most an efficient dose of 1.4 mSv, 8 persons received at the most an efficient dose of 0.9 mSv, 11 persons received at the most an efficient dose between 0.2 and 0.7 mSv, 15 persons received at the most an efficient dose between 0.1 and 0.2 mSv included. (N.C.)

  2. 77 FR 59675 - Compliance With Information Request, Flooding Hazard Reevaluation

    Science.gov (United States)

    2012-09-28

    ... COMMISSION Compliance With Information Request, Flooding Hazard Reevaluation AGENCY: Nuclear Regulatory... was needed in the areas of seismic and flooding design, and emergency preparedness. In addition to... licensees reevaluate flooding hazards at nuclear power plant sites using updated flooding hazard...

  3. US experience in seismic re-evaluation and verification programs

    International Nuclear Information System (INIS)

    The purpose of this paper is to present a summary of the development of the seismic re-evaluation program for older nuclear power plants in the US. The principal focus of this re-evaluation is the use of actual strong motion earthquake response data for structures, mechanical and electrical systems and components. These data are supplemented by shake table test results. This type of seismic re-evaluation has lead to major cost reduction as compared to more conventional analytical and component specific testing procedures. (orig.)

  4. Site characterization plan thermal goals reevaluation

    International Nuclear Information System (INIS)

    The Site Characterization Plan (SCP) (DOE, 1988) attempted to define surrogate criteria that could be used to establish potential repository performance. These criteria or SCP thermal goals were developed from knowledge existing at the time and, as a reference case, emphasized performance for waste emplacement in a vertical borehole. Since that time, new knowledge has become available and some additional analyses of thermal loading have been performed. Additionally, other emplacement modes such as in-drift emplacement are being considered to accommodate larger waste packages. New concepts such as ''extended hot'' are also being considered as possible methods to achieve improved waste isolation. Thus it became clear that the thermal goals established in the SCP should be reevaluated. A Working Group was formed to reassess the SCP thermal goals to determine whether each goal was still valid, if there were goals that needed to be added, and what if any effort was needed to reduce the uncertainty associated with a particular goal. The objectives of the effort were to: (1) provide thermal goals that would support the FY 1993 Thermal Loading Systems Study; (2) help focus the planned testing and analysis efforts; and (3) acquire data that potentially could be used to initiate a change to the project technical baseline. Sixteen thermal goals were evaluated; fifteen were from various sections of the SCP; one goal was added, and another was split into two to include in-drift emplacement. The group's findings and recommendations are presented

  5. Landscape, Process and Power: Re-evaluating Traditional Environmental Knowledge

    OpenAIRE

    Colleen Marie O'Brien

    2010-01-01

    Review of Landscape, Process and Power: Re-evaluating Traditional Environmental Knowledge. Serena Heckler, ed. 2009. Berghahn Books, New York. Pp. 304, 21 illustrations, bibliography, index. $95.00 (hardback). ISBN 978-1-84545-549-1

  6. 77 FR 65417 - Compliance With Information Request, Flooding Hazard Reevaluation

    Science.gov (United States)

    2012-10-26

    ... COMMISSION Compliance With Information Request, Flooding Hazard Reevaluation AGENCY: Nuclear Regulatory... nuclear power reactor applicants and licensees with performing a flooding hazard reanalysis in response to... whether further regulatory action was needed in the areas of seismic and flooding design, and...

  7. 78 FR 24439 - Compliance With Information Request, Flooding Hazard Reevaluation

    Science.gov (United States)

    2013-04-25

    ... COMMISSION Compliance With Information Request, Flooding Hazard Reevaluation AGENCY: Nuclear Regulatory... Directorate Interim Staff Guidance (JLD- ISG), JLD-ISG-2013-01, ``Guidance for Estimating Flooding Hazards due... flooding hazards due to dam failure for the purpose of responding to enclosure 2 of a March 12,...

  8. Men in nursing: re-evaluating masculinities, re-evaluating gender.

    Science.gov (United States)

    Brown, Brian

    2009-10-01

    This paper critically interrogates and re-evaluates the notion that it is somehow difficult being a man in nursing and suggests some ways forward which will allow us to gain a more politically astute purchase on gender, nursing and the socio-political context in which the profession operates. Men appear to be well served by a career in nursing. Despite their lesser numbers they are likely to earn more and be promoted into leadership roles more readily. Yet there is a pervasive sense in the literature on men in nursing that they feel unhappy as a minority in a predominantly female occupation and feel a disjuncture between masculine identity and the nursing role. The genealogy of this idea can be traced to a more extensive literature in the 'men's movement', in sex role theory and masculinity studies which has tended to focus on the putative hurts that men suffer as they are socialized into the male role. This is itself informed by experiences and discourses from therapy, and privileges these kinds of experiences over and above more sober consideration of the respective powers of men and women and the sociopolitical context of the profession. This 'poor me' discourse deflects attention away from the business of tackling material inequalities and enables men to encroach further into the agenda of nursing discussions. Instead, a view of men and women in nursing is proposed which is attentive to the historical and political operations of power and which sees subjective experiences as the effects of power rather than as a starting point for analysis. We must place individual experience coherently and exhaustively in the material environment of social space and time. It is in this way that we can genuinely advance the interest of men and women and build an effective profile for the profession as a whole.

  9. TRIGA mark-II,III reactor safety re-evaluation

    International Nuclear Information System (INIS)

    For two years of 1990 and 1991, the safety of TRIGA Mk-II and III reactor has been re-evaluated. For this, domestic rules on research reactors has been reviewed, and as it was judged that standards on research reactors in USA is applicable to our ones it was evaluated whether TRIGA Mk-II and III reactors satisfy these standards. The site parameters and the environmental impacts during normal operation and hypothetical accident conditions have been analysed, and those parts for reactor facility and structure have been rewritten to fit SAR standard format based on the review of old SAR and maintenance manuals reflecting changes after the construction. Based on this re-evaluation, SAR, Technical Specifications, Radiation Emergency Plan, Environment Report, various procedures,etc. will be amended by the reactor management project. (Author)

  10. Re-evaluation of azo dyes as food additives

    DEFF Research Database (Denmark)

    Pratt, Iona; Larsen, John Christian; Mortensen, Alicja;

    2013-01-01

    additives to be assessed by the Scientific Committee on Food, many years ago, (ii) because of concern regarding possible health effects of artificial colours arising since the original evaluations.Concerns includedbehavioural effects in children, allergic reactions, genotoxicity and possible carcinogenicity......Aryl azo compounds are widely used as colorants (azo dyes) in a wide range of products including textiles, leather, paper, cosmetics, pharmaceuticals and food.As part of its systematic re-evaluation of food additives, the European Food Safety Authority (EFSA) has carried out new risk assessments...... of allazo dyes permitted in food. EFSA has also evaluated a number of azo dyes found illegally in food in recent years, including Sudan dyes, Para Red and Orange II. The re-evaluation of all food colours, including the azo dyes,was considered high priority (i) because colorants were among the first...

  11. Reevaluation of honeybee (Apis mellifera) microtaxonomy: a geometric morphometric approach

    OpenAIRE

    Kandemir, Irfan; Özkan, Ayça; FUCHS, Stefan

    2011-01-01

    International audience In the present study, the microtaxonomy of honeybee (Apis mellifera L.) subspecies was reevaluated based on a geometric morphometric method. Wing images of honeybee subspecies, obtained from the Morphometric Bee Data Bank in Oberursel, Germany, were assigned to four honeybee lineages from the indivudial images, and 40 Cartesian coordinates were obtained. Honeybee lineages were significantly different based on individual and colony consensus average wing shapes of hon...

  12. Prostate needle biopsies: interobserver variation and clinical consequences of histopathological re-evaluation

    DEFF Research Database (Denmark)

    Berg, Kasper Drimer; Toft, Birgitte Grønkaer; Brasso, Klaus;

    2011-01-01

    Histopathological grading of prostate cancer (PCa) is associated with significant interobserver variability. This, as well as clinical consequences of histopathological re-evaluation, was investigated. In 350 patients, histopathological re-evaluations of prostate biopsies were compared with primary...... pathology reports and with histopathology of the radical prostatectomy specimen. The consequences of re-evaluation for clinical workup and treatment of patients according to local algorithms were determined. For Gleason score (GS), complete agreement between primary report and re-evaluation was found in 76...

  13. Triga mark-II,III reactor safety re-evaluation

    International Nuclear Information System (INIS)

    In order to revise safety analysis report of old TRIGA reactors, safety re-evaluation of these reactor was started for necessary parts. This report contains the first year results of the project scheduled for two years. The guide lines of safety re-evaluation was made by translating that of nuclear power plant from the view point of TRIGA reactor confirming the basic safety philosophy as much as possible. First of all, sections of reactor history and comparison with similar reactors are made, since the actual operation records, changes, any modification of similar reactors constructed after then, etc., are realistic and valuable data from the safety aspect of old reactor. For the effectiveness of nuclear analysis, a PC based analysis system using WIMS-D/4 and VENTURE was established, and a program for the natural convection cooling analysis of TRIGA reactor was developed. As a result of thermal-hydraulic analysis it was confirmed that the operation limit of fuel temperature set at 650 deg C without any logical reason is very close to the DNB limit. (Author)

  14. 34 CFR 300.305 - Additional requirements for evaluations and reevaluations.

    Science.gov (United States)

    2010-07-01

    ... defined in § 300.8, and the educational needs of the child; or (B) In case of a reevaluation of a child, whether the child continues to have such a disability, and the educational needs of the child; (ii) The... child needs special education and related services; or (B) In the case of a reevaluation of a...

  15. 12 CFR 560.172 - Re-evaluation of real estate owned.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Re-evaluation of real estate owned. 560.172 Section 560.172 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY LENDING AND INVESTMENT Lending and Investment Provisions Applicable to all Savings Associations § 560.172 Re-evaluation of real estate owned. A...

  16. 24 CFR 58.47 - Re-evaluation of environmental assessments and other environmental findings.

    Science.gov (United States)

    2010-04-01

    ... circumstances and environmental conditions which may affect the project or have a bearing on its impact, such as... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Re-evaluation of environmental....47 Re-evaluation of environmental assessments and other environmental findings. (a) A...

  17. Reevaluation of conventional pituitary irradiation in the therapy of acromegaly.

    Science.gov (United States)

    Jaffe, C A

    1999-06-01

    External beam pituitary irradiation has been frequently used in the treatment of growth hormone (GH) secreting pituitary adenomas. Many studies have demonstrated that serum GH declines rapidly and reliably following treatment and early "cure" rates, based on a basal serum GH below 10 micrograms/L were as high as 80%. The definition of "cure" has become more stringent over time and retrospective studies have indicated that GH must be below 2.5 micrograms/L for acromegalics to achieve mortality rates comparable to a normal population. Only 20% of irradiated patients will achieve this goal by 10 yr. Even fewer will achieve a normal serum insulin-like growth factor I (IGF-I) levels. Although pituitary irradiation still has a role in the control of tumor size, its importance as a treatment for normalizing serum GH is being reevaluated. PMID:11081173

  18. Re-evaluating the Contribution and Legacy of Hedley Bull

    Directory of Open Access Journals (Sweden)

    Emerson Maione Souza

    2008-06-01

    Full Text Available The article aims, in the first instance, to make a detailed analysis of the work of Hedley Bull, approaching the main themes and concepts developed by him. Secondly, it aims to re-evaluate the potential of the author’s contribution, given the new conditions of the post-Cold War period. With this in mind, the article critically analyses the most recent interpretations of this work, which seek to highlight its critical and normative potential, as well as to dissociate it from the realist tradition in international relations. These two facts differentiate the new commentators from older ones and reaffirm the continuing relevance of Hedley Bull’s work, the latter being the article’s chief conclusion.

  19. Reevaluation of ethnologic field research of the Dogon

    Directory of Open Access Journals (Sweden)

    Kovač Senka

    2010-01-01

    Full Text Available One of the events that marked the last decade of the 20th century was a more intensive re-evaluation of the work of Marcel Griaule (1898-1956, who was the first French ethnologist to conduct planned field research among the Dogon of Western Africa, in the period between 1931 and 1956. Griaule’s work had previously been re-examined in the sixties, in France (Georges Balandier, Great Britain (Mary Douglas and in other places. British social anthropologists had put forward a critique of Griaule’s field methods, concentrating on his use of translators and work with privileged informants. Van Beek’ repeated study from 1991 started the new wave of polemic that came to include Griaule’s old critics, associates and relatives. Some of the participants in this debate interpreted Van Beek’s “attack” on Griaule as - inspired by Freeman’s critique of Mead, and the general trend of reevaluations - of anthropology’s leading figures at the close of the 20th century. The objective of Van Beek’s repeated study was to evaluate the reliability of Griaule’s findings. Van Beek emphasized three groups of errors in Griaule’s research: 1 the scarcity of data; 2 the unverifiability of data; 3 the inappropriateness of analyses. Van Beeks’ repeated study did not reach the level of controversy that followed the Mead-Freeman polemic in the eighties. On the other hand, it puit forward an important question on whether French anthropology can face selfcriticism, and established Dutch academic presence in Western Africa The French advocates of “New Dogon anthropology” focus their research on time “before Ogotemmêli” and “after Ambara”. Another important improvement represents the inclusion of local Dogon scholars.

  20. 77 FR 73114 - Draft Written Re-Evaluation for Environmental Impact Statement: T.F. Green Airport, Warwick, RI

    Science.gov (United States)

    2012-12-07

    ... Federal Aviation Administration Draft Written Re-Evaluation for Environmental Impact Statement: T.F. Green... Draft Written Re-Evaluation for an Environmental Impact Statement (EIS) has been prepared for Theodore... to T.F. Green Draft Written Re-Evaluation'' in the subject line Mail: Richard Doucette,...

  1. Chernobyl-Related Cancer: Re-Evaluation Needed

    Directory of Open Access Journals (Sweden)

    Sergei JARGIN

    2010-05-01

    Full Text Available There has been no clearly demonstrated cancer incidence increase that can be attributed to radiation from Chernobyl accident, except for the thyroid carcinoma in the individuals exposed in childhood and adolescence. The drastic increase of thyroid cancer started 4 years after the accident. The solid/follicular subtype of papillary thyroid carcinoma predominated in the early period after the accident. Histopathological diagnosis of cancer in such cases, if no infiltrative growth is visible, is based mainly on the nuclear criteria of papillary carcinoma. Outdated equipment of histopathological laboratories in early 1990s and insufficient quality of histological sections hindered reliable assessment of the nuclear criteria. Access to foreign professional literature has been limited in the former Soviet Union. Appearance of advanced tumors shortly after the accident can be explained by the screening effect with detection of neglected cancers and by the fact that patients were brought from other regions of the former Soviet Union and registered as Chernobyl-related cases. Further evidence in favor of the overestimation of thyroid cancer incidence after Chernobyl accident is discussed. The concluding point is that immunohistochemical and molecular-genetic tests performed within the scope of international studies were partly based on an inadequately selected material, and that supposedly specific features of radiogenic post-Chernobyl cancers characterize, on average, a later stadium of tumor progression. Therefore, some published data on molecular-genetic and other characteristics of post-Chernobyl malignancies require re-evaluation.

  2. Re-evaluation of monitored retrievable storage concepts

    International Nuclear Information System (INIS)

    In 1983, as a prelude to the monitored retrievable storage (MRS) facility conceptual design, the Pacific Northwest Laboratory (PNL) conducted an evaluation for the US Department of Energy (DOE) that examined alternative concepts for storing spent LWR fuel and high- level wastes from fuel reprocessing. The evaluation was made considering nine concepts for dry away-from-reactor storage. The nine concepts evaluated were: concrete storage cask, tunnel drywell, concrete cask-in-trench, open-cycle vault, metal casks (transportable and stationary), closed-cycle vault, field drywell, and tunnel-rack vault. The purpose and scope of the re-evaluation did not require a repetition of the expert-based examinations used earlier. Instead, it was based on more detailed technical review by a small group, focusing on changes that had occurred since the initial evaluation was made. Two additional storage concepts--the water pool and the horizontal modular storage vault (NUHOMS system)--were ranked along with the original nine. The original nine concepts and the added two conceptual designs were modified as appropriate for a scenario with storage capacity for 15,000 MTU of spent fuel. Costs, area requirements, and technical and historical data pertaining to MRS storage were updated for each concept

  3. Status of seismic re-evaluation and upgrading of KANUPP

    International Nuclear Information System (INIS)

    The seismic upgrading activities at Karachi Nuclear Power Plant (KANUPP) began in 1992 after a preliminary plan was chalked out with IAEA to conduct the seismic walkdown of the plant and initiate site studies to reconfirm geotechnical parameters and determine new seismic input. Consequently, the seismic walkdown was arranged in May 1993. The site geotechnical parameters were re-evaluated by performing the geotechnical investigations and cross hole seismic survey. This was followed by collection of data for seismic studies, geological surveys, surface fault studies and development of a seismotectonic model for determining the new seismic parameters as per IAEA safety guide no. 50-SG-SI. In parallel with the seismic studies, the short term fixes work was also initiated with iRLE value but gained momentum during the last six months. Dynamic analyses of some structures/equipments identified by the IAEA mission with a fabricated spectra and cross checked with simplified techniques have been completed and retrofitting/anchoring details provided to the implementation division while analyses/fixes design of other structures are in progress. (author)

  4. Arsenic hydrogeochemistry in an irrigated river valley - A reevaluation

    Science.gov (United States)

    Nimick, D.A.

    1998-01-01

    Arsenic concentrations in ground water of the lower Madison River valley, Montana, are high (16 to 176 ??g/L). Previous studies hypothesized that arsenic-rich river water, applied as irrigation, was evapoconcentrated during recharge and contaminated the thin alluvial aquifer. Based on additional data collection and a reevaluation of the hydrology and geochemistry of the valley, the high arsenic concentrations in ground water are caused by a unique combination of natural hydrologic and geochemical factors, and irrigation appears to play a secondary role. The high arsenic concentrations in ground water have several causes: direct aquifer recharge by Madison River water having arsenic concentrations as high as 100 ??g/L, leaching of arsenic from Tertiary volcano-clastic sediment, and release of sorbed arsenic where redox conditions in ground water are reduced. The findings are consistent with related studies that demonstrate that arsenic is sorbed by irrigated soils in the valley. Although evaporation of applied irrigation water does not significantly increase arsenic concentrations in ground water, irrigation with arsenic-rich water raises other environmental concerns.

  5. Reevaluation of lake trout and lake whitefish bioenergetics models

    Science.gov (United States)

    Madenjian, Charles P.; Pothoven, Steve A.; Kao, Yu-Chun

    2013-01-01

    Using a corrected algorithm for balancing the energy budget, we reevaluated the Wisconsin bioenergetics model for lake trout (Salvelinus namaycush) in the laboratory and for lake whitefish (Coregonus clupeaformis) in the laboratory and in the field. For lake trout, results showed that the bioenergetics model slightly overestimated food consumption by the lake trout when they were fed low and intermediate rations, whereas the model predicted food consumption by lake trout fed ad libitum without any detectable bias. The slight bias in model predictions for lake trout on restricted rations may have been an artifact of the feeding schedule for these fish, and we would therefore recommend application of the Wisconsin lake trout bioenergetics model to lake trout populations in the field without any revisions to the model. Use of the Wisconsin bioenergetics model for coregonids resulted in overestimation of food consumption by lake whitefish both in the laboratory and in the field by between 20 and 30%, on average. This overestimation of food consumption was most likely due to overestimation of respiration rate. We therefore adjusted the respiration component of the bioenergetics model to obtain a good fit to the observed consumption in our laboratory tanks. The adjusted model predicted the consumption in the laboratory and the field without any detectable bias. Until a detailed lake whitefish respiration study can be conducted, we recommend application of our adjusted version of the Wisconsin generalized coregonid bioenergetics model to lake whitefish populations in the field.

  6. Reevaluation of a walleye (Sander vitreus) bioenergetics model

    Science.gov (United States)

    Madenjian, Charles P.; Wang, Chunfang

    2013-01-01

    Walleye (Sander vitreus) is an important sport fish throughout much of North America, and walleye populations support valuable commercial fisheries in certain lakes as well. Using a corrected algorithm for balancing the energy budget, we reevaluated the performance of the Wisconsin bioenergetics model for walleye in the laboratory. Walleyes were fed rainbow smelt (Osmerus mordax) in four laboratory tanks each day during a 126-day experiment. Feeding rates ranged from 1.4 to 1.7 % of walleye body weight per day. Based on a statistical comparison of bioenergetics model predictions of monthly consumption with observed monthly consumption, we concluded that the bioenergetics model estimated food consumption by walleye without any significant bias. Similarly, based on a statistical comparison of bioenergetics model predictions of weight at the end of the monthly test period with observed weight, we concluded that the bioenergetics model predicted walleye growth without any detectable bias. In addition, the bioenergetics model predictions of cumulative consumption over the 126-day experiment differed fromobserved cumulative consumption by less than 10 %. Although additional laboratory and field testing will be needed to fully evaluate model performance, based on our laboratory results, the Wisconsin bioenergetics model for walleye appears to be providing unbiased predictions of food consumption.

  7. Five-Year NRHP Re-Evaluation of Historic Buildings Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Ullrich, R A; Heidecker, K R

    2011-09-12

    The Lawrence Livermore National Laboratory (LLNL) 'Draft Programmatic Agreement among the Department of Energy and the California State Historic Preservation Officer Regarding Operation of Lawrence Livermore National Laboratory' requires a review and re-evaluation of the eligibility of laboratory properties for the National Register of Historic Places (NRHP) every five years. The original evaluation was published in 2005; this report serves as the first five-year re-evaluation. This re-evaluation includes consideration of changes within LLNL to management, to mission, and to the built environment. it also determines the status of those buildings, objects, and districts that were recommended as NRHP-eligible in the 2005 report. Buildings that were omitted from the earlier building list, those that have reached 50 years of age since the original assessment, and new buildings are also addressed in the re-evaluation.

  8. 75 FR 49930 - Stakeholder Meeting Regarding Re-Evaluation of Currently Approved Total Coliform Analytical Methods

    Science.gov (United States)

    2010-08-16

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Stakeholder Meeting Regarding Re-Evaluation of Currently Approved Total Coliform Analytical...) analytical methods. At these meetings, stakeholders will be given an opportunity to discuss...

  9. Periodic safety re-evaluations in NPPs in EC member states, Finland and Sweden

    International Nuclear Information System (INIS)

    The work on periodic safety re-evaluations summarized in this report was performed by a Task Force of the CEC Working Group on the Safety of Thermal Reactors. The periodic safety re-evaluations under review in this study were those that are carried out in addition to other reviews which represent the primary means of safety assurance. The periodic safety re-evaluation is broader and more comprehensive in nature. The cumulative effects of experience (national and international), advances in knowledge and analysis techniques, improvements in safety standards and operating practices, overall effects of plant ageing, and the totality of all modifications over the period in question need to be taken into account. All countries have recognized the value of such periodic reviews, and licensees, either as a regulatory requirement or as a voluntary action, are carrying them out. The scope and contents of each country's review showed many similarities of approach, any differences being explained by the age and type of reactor in operation. Many similarities emerged in the topics selected for re-evaluation and in the approach to re-evaluation itself. The overall conclusion was that while approaches may differ in some respects, for practical purposes comparable levels of safety are achieved in the periodic safety re-evaluation of nuclear power plants

  10. Reevaluating the functional implications of Australopithecus afarensis navicular morphology.

    Science.gov (United States)

    Prang, Thomas C

    2016-08-01

    The longitudinal arch is a unique characteristic of the human foot, yet the timing and pattern of its evolution remain controversial, in part due to the disagreement among researchers over which skeletal traits are the best indicators of its presence or absence. The small size of the human navicular tuberosity has previously been linked to the presence of a longitudinal arch, implying that the large tuberosity of early hominins such as Australopithecus afarensis reflects a flat foot. However, this hypothesis is at odds with other evidence of pedal form and function, such as metatarsal, tarsal, and footprint morphology, which show that a longitudinal arch was probably present in A. afarensis. This study reevaluates the morphometric affinities of the A. afarensis naviculars among other Plio-Pleistocene fossil hominins and anthropoid primates (N = 170). Multivariate cluster analyses show that all fossil hominin naviculars, including those attributed to A. afarensis, are most similar to modern humans. A measure of navicular tuberosity size quantified as the ratio of the tuberosity volume to the surface area of the talar facet shows that Ateles has the largest navicular tuberosity among the anthropoid sample and that there is no difference between highly arboreal and terrestrial taxa in this metric (e.g., Hylobates and Gorilla beringei). Instead, a relatively large navicular tuberosity may reflect the development of leg musculature associated with ankle plantarflexion. The functional inferences derived from the morphology of the A. afarensis naviculars are consistent with the morphology of the Laetoli footprints. PMID:27457546

  11. Re-evaluation of seismic design for JOYO buildings and equipments

    Energy Technology Data Exchange (ETDEWEB)

    Isozaki, K.; Tomita, N. [Power Reactor and Nuclear Fuel Development Corp., Oarai, Ibaraki (Japan). Oarai Engineering Center

    1997-07-01

    Hyougo-ken southern earthquake broke out in 1997/01/17. The Atomic Energy Safety Commission considered reasonable of the design guide for seismic design. And the Science and Technology Agency (STA) required reevaluation of atomic power facilities built by old design guide according to the new seismic design guide. JOYO obtained the construction license in 1970/02. Heat transport system and buildings of JOYO was re-evaluated by the new seismic design guide for the MK-III project. So, JOYO was not required re-evaluation by STA. But, this evaluation of MK-III was limited to reconstruction area, and the seismic design was reevaluated extensively to confirm earthquake proof characteristics. The structural integrity of buildings and equipments was confirmed by the result of reevaluation by the new seismic design guide. The analysis model conditions were established according to the 1987 and 1991 version of JEAG. This was done by ground investigation result and buildings vibration test. It was made clear that the analysis model conditions were reasonable and conservative from a technical view point. (author)

  12. 24 CFR 35.1355 - Ongoing lead-based paint maintenance and reevaluation activities.

    Science.gov (United States)

    2010-04-01

    ... assessor. (4) Each reevaluation shall be conducted in accordance with the following schedule if a risk... assessor shall review any available past evaluation, hazard reduction and clearance reports, and any other... building operations. (ii) Visual assessment. The risk assessor shall: (A) Visually evaluate all...

  13. Loveless Frump as Hip and Sexy Party Girl: A Reevaluation of the Old-Maid Stereotype.

    Science.gov (United States)

    Adams, Katherine C.

    2000-01-01

    Argues for a reevaluation of the old-maid stereotype that will allow professionals in the library and information science (LIS) field to embrace digital technology while remaining mindful of their distinctiveness and recognizing the stereotype as an important part of their collective identity and professional history. (Contains 55 references.)…

  14. Reevaluation of the indications for permanent pacemaker implantation after transcatheter aortic valve implantation

    DEFF Research Database (Denmark)

    Bjerre Thygesen, Julie; Loh, Poay Huan; Cholteesupachai, Jiranut;

    2014-01-01

    AIMS: Conduction abnormalities (CA) requiring permanent pacemaker (PPM) are a well-known complication after transcatheter aortic valve implantation (TAVI). This study aimed to determine the incidence of TAVI-related PPM and reevaluate the indications for PPM after the periprocedural period. METHO...

  15. Reevaluation of the Amsterdam Inventory for Auditory Disability and Handicap Using Item Response Theory

    Science.gov (United States)

    Hospers, J. Mirjam Boeschen; Smits, Niels; Smits, Cas; Stam, Mariska; Terwee, Caroline B.; Kramer, Sophia E.

    2016-01-01

    Purpose: We reevaluated the psychometric properties of the Amsterdam Inventory for Auditory Disability and Handicap (AIADH; Kramer, Kapteyn, Festen, & Tobi, 1995) using item response theory. Item response theory describes item functioning along an ability continuum. Method: Cross-sectional data from 2,352 adults with and without hearing…

  16. Reevaluating the Aims of Modern Dance Training in Korea: Toward a Whole Dancer

    Science.gov (United States)

    Kim, Na-ye

    2013-01-01

    This study reevaluates modern dance training in Korea and attempts to identify possible improvements. This study is based on the rationale that Korean modern dance training must recover its nature of a holistic connection between body and mind. A qualitative methodology was used to interpret data from in-depth interviews and open-ended…

  17. 76 FR 42762 - Final Written Re-Evaluation for Environmental Impact Statement: Sikorsky Memorial Airport...

    Science.gov (United States)

    2011-07-19

    ... Federal Aviation Administration Final Written Re-Evaluation for Environmental Impact Statement: Sikorsky... Final Environmental Impact Statement (FEIS) has been completed for Sikorsky Memorial Airport in... analysis contained in a Final Environmental Impact Statement (FEIS) that the FAA issued in May 1999....

  18. 75 FR 55846 - Draft Re-Evaluation for Environmental Impact Statement: Sikorsky Memorial Airport, Stratford, CT

    Science.gov (United States)

    2010-09-14

    ... Federal Aviation Administration Draft Re-Evaluation for Environmental Impact Statement: Sikorsky Memorial... Environmental Impact Statement (EIS) has been prepared for Sikorsky Memorial Airport in Stratford, Connecticut... INFORMATION: The FAA is making available a Draft Re- Evaluation document, which evaluates the impacts...

  19. Staged re-evaluation of non-culprit lesions in ST segment elevation myocardial infarction: a retrospective study

    Science.gov (United States)

    Thim, Troels; Egholm, Gro; Olesen, Kevin Kris Warnakula; Kaltoft, Anne; Terkelsen, Christian Juhl; Krusell, Lars Romer; Kristensen, Steen Dalby; Bøtker, Hans Erik; Christiansen, Evald Høj; Maeng, Michael

    2016-01-01

    Objective It remains unknown whether complete revascularisation is optimally performed in patients with ST segment elevation myocardial infarction (STEMI) during the index or at staged procedures. The aims of this study were to quantify the number of primary percutaneous coronary intervention (PCI) procedures in which non-culprit lesions needed further evaluation, to determine the consequence of the re-evaluation and to quantify adverse cardiac events during the waiting time for re-evaluation and intervention. Methods The study was observational and retrospective and included all patients with STEMI treated with primary PCI during 1 year at our centre. Results Among the 507 patients with STEMI, 374 were considered sufficiently treated with culprit lesion PCI only. Complete primary multivessel revascularisation was performed in 11 patients. Non-culprit lesion re-evaluation was planned for 122 patients (24%). Of these 122 patients, 3 patients died during their index admission. Follow-up data were not available for 3 patients. Among the 116 patients, 187 non-culprit lesions were re-evaluated and 77 patients (66.4%) underwent revascularisation with treatment of 119 lesions (63.3%). Re-evaluation was performed after a median of 30 days (25th centile: 9 days, 75th centile: 35 days). During the waiting time for re-evaluation, two patients underwent a new primary PCI due to stent thrombosis of the index culprit lesion. Conclusions Staged re-evaluation of non-culprit lesions observed in patients with STEMI was required in 24% of a primary PCI cohort. Intervention was performed in 66.4% of patients scheduled for re-evaluation. We observed no adverse events related to the non-culprit lesions during the waiting time for a staged re-evaluation or intervention. PMID:27403331

  20. Proceedings of the workshop on the seismic re-evaluation of all nuclear facilities

    International Nuclear Information System (INIS)

    The Committee on the Safety of Nuclear Installations (CSNI) of the OECD-NEA co-ordinates the NEA activities concerning the technical aspects of design, construction and operation of nuclear installations insofar as they affect the safety of such installations. The Integrity and Ageing Working Group (IAGE WG) of the CSNI deals with the integrity of structures and components, and has three sub-groups, dealing with the integrity of metal components and structures, ageing of concrete structures, and the seismic behaviour of structures. This workshop was proposed by the sub-group dealing with the seismic behaviour of structures. Seismic re-evaluation is identified as the process of carrying out a re-assessment of the safety of existing nuclear facilities for a specified seismic hazard. This may be necessary when no seismic hazard was considered in the original design of the plant, the relevant codes and regulations have been revised, the seismic hazard for the site has been re-assessed or there is a need to assess the capacity of the plant for severe accident conditions and behaviour beyond the design basis. Re-evaluation may also be necessary to resolve an issue, or to assess the impact of new findings or knowledge. In 1997, CSNI recognised the increasing importance of seismic re-evaluation for nuclear facilities throughout the world. It prepared a status report on seismic Re-evaluation NEA/CSNI/R(98)5 which summarized the current situation for Member countries of the OECD. The report suggested a number of areas of the seismic reevaluation process, which could be considered in the future. In May 2000, the seismic sub-group reviewed these suggestions and determined that it was timely to address progress on this topic through this workshop. The workshop focused on methods and acceptance criteria and, on countermeasures and strengthening of plant. The workshop had 2 technical sessions listed below devoted to presentations, and a 3. session devoted to a discussion of the

  1. Reevaluation of the Parton Distribution of Strange Quarks in the Nucleon

    CERN Document Server

    Airapetian, A; Akopov, Z; Aschenauer, E C; Augustyniak, W; Avetissian, A; Avetisyan, E; Belostotski, S; Blok, H P; Borissov, A; Bryzgalov, V; Burns, J; Capiluppi, M; Capitani, G P; Cisbani, E; Ciullo, G; Contalbrigo, M; Dalpiaz, P F; Deconinck, W; De Leo, R; De Sanctis, E; Diefenthaler, M; Di Nezza, P; Düren, M; Ehrenfried, M; Elbakian, G; Ellinghaus, F; Etzelmüller, E; Felawka, L; Frullani, S; Gabbert, D; Gapienko, G; Gapienko, V; García, J Garay; Garibaldi, F; Gavrilov, G; Gharibyan, V; Giordano, F; Gliske, S; Hartig, M; Hasch, D; Hoek, M; Holler, Y; Hristova, I; Jackson, H E; Joosten, S; Kaiser, R; Karyan, G; Keri, T; Kinney, E; Kisselev, A; Korotkov, V; Kozlov, V; Kravchenko, P; Krivokhijine, V G; Lagamba, L; Lapikás, L; Lehmann, I; Lenisa, P; Lorenzon, W; Ma, B -Q; Mahon, D; Manaenkov, S I; Mao, Y; Marianski, B; Marukyan, H; Miyachi, Y; Movsisyan, A; Muccifora, V; Murray, M; Mussgiller, A; Naryshkin, Y; Nass, A; Negodaev, M; Nowak, W -D; Pappalardo, L L; Perez-Benito, R; Petrosyan, A; Reimer, P E; Reolon, A R; Riedl, C; Rith, K; Rosner, G; Rostomyan, A; Rubin, J; Ryckbosch, D; Salomatin, Y; Schäfer, A; Schnell, G; Seitz, B; Shibata, T -A; Stahl, M; Statera, M; Steffens, E; Steijger, J J M; Stinzing, F; Taroian, S; Terkulov, A; Truty, R; Trzcinski, A; Tytgat, M; Van Haarlem, Y; Van Hulse, C; Veretennikov, D; Vikhrov, V; Vilardi, I; Vogel, C; Wang, S; Yaschenko, S; Ye, Z; Yen, S; Zihlmann, B; Zupranski, P

    2013-01-01

    An earlier extraction from the HERMES experiment of the polarization-averaged parton distribution of strange quarks in the nucleon has been reevaluated using final data on the multiplicities of charged kaons in semi-inclusive deep-inelastic scattering obtained with a kinematically more comprehensive method of correcting for experimental effects. General features of the distribution are confirmed, but the rise at low $x$ is less pronounced than previously reported.

  2. Reevaluation of the parton distribution of strange quarks in the nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Airapetian, A. [Giessen Univ. (Germany). II. Physikalisches Institut; Michigan Univ., Ann Arbor, MI (United States). Randall Laboratory of Physics; Akopov, N. [Yerevan Physics Institute (Argentina); Akopov, Z. [DESY Hamburg (Germany); Collaboration: HERMES Collaboration; and others

    2013-12-15

    An earlier extraction from the HERMES experiment of the polarization-averaged parton distribution of strange quarks in the nucleon has been reevaluated using final data on the multiplicities of charged kaons in semi-inclusive deep-inelastic scattering obtained with a kinematically more comprehensive method of correcting for experimental effects. General features of the distribution are confirmed, but the rise at low x is less pronounced than previously reported.

  3. Reevaluating nuclear safety and security in a post 9/11 era.

    Energy Technology Data Exchange (ETDEWEB)

    Booker, Paul M.; Brown, Lisa M.

    2005-07-01

    This report has the following topics: (1) Changing perspectives on nuclear safety and security; (2) Evolving needs in a post-9/11 era; (3) Nuclear Weapons--An attractive terrorist target; (4) The case for increased safety; (5) Evolution of current nuclear weapons safety and security; (6) Integrated surety; (7) The role of safety and security in enabling responsiveness; (8) Advances in surety technologies; and (9) Reevaluating safety.

  4. Orphan caribou, Rangifer tarandus, calves: A re-evaluation of overwinter survival data

    Science.gov (United States)

    Joly, Kyle

    2000-01-01

    Low sample size and high variation within populations reduce power of statistical tests. These aspects of statistical power appear to have affected an analysis comparing overwinter survival rates of non-orphan and orphan Caribou (Rangifer tarandus) calves by an earlier study for the Porcupine Caribou Herd. A re-evaluation of the data revealed that conclusions about a lack of significant difference in the overwinter survival rates between orphan and non-orphan calves were premature.

  5. Re-evaluation of potential impacts of runoff from a Dare County Landfill On Alligator River National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Sediment samples were collected from 9 sites on Alligator River National Wildlife Refuge (Dare County, NC) in September 2005 to re-evaluate the potential impacts of...

  6. Reevaluating Surface Composition of Asteroid (4) Vesta by Comparing HED Spectral Data with Dawn Framing Camera (FC) Observations

    Science.gov (United States)

    Giebner, T.; Jaumann, R.; Schröder, S.

    2016-08-01

    This master's thesis project tries to reevaluate previous findings on asteroid (4) Vesta's surface composition by using DAWN FC Filter image ratios in a new way in order to identify HED (howardite, eucrite, diogenite) lithologies on the surface.

  7. [Research about re-evaluation of screening of traditonal Chinese medicine symptoms item of post-marketing medicine Xuezhikang].

    Science.gov (United States)

    He, Wei; Xie, Yanming; Wang, Yongyan

    2011-10-01

    The purpose of post-marketing Chinese medicine re-evaluation is to identify Chinese medicine clinical indications, while designing scientific and rational of Chinese medicine symptoms items are important to the result of symptoms re-evaluation. This study give screening of traditional Chinese medicine(TCM) symptoms item of post-marketing medicine Xuezhikang re-evaluation as example that reference to principle dyslipidemia clinical research, academic dissertations, Xuezhikang directions, clinical expert practice experience etc. while standardization those symptom names and screening 41 dyslipidemia common symptoms. Furthermore, this paper discuss about the accoerdance and announcements when screening symptoms item, so as to providing a research thread to manufacture PRO chart for post-marketing medicine re-evaluation. PMID:22292395

  8. ACCOUNTING AND TAX TREATMENT OF THE RE-EVALUATION OF THE TANGIBLE ASSETS

    Directory of Open Access Journals (Sweden)

    Daniela CRETU

    2013-01-01

    Full Text Available The methods of patrimonial evaluation are recognised on a large scale by the specialists in the Continental Europe, while the specialists in the North America almost ignore them, they consider as a realistic economic value the one that results from the update of the forecast cash-flows. The Romanian financial school does not mention at present a basic orientation related to the continental or American opinion. In general, it can be found out that the attitude of the Romanian authors, specialised in the accounting domain, is for the patrimonial methods, and those in financial professional domain, is for the financial and stock methods. According to the International Standards for business evaluation, the “asset based approach is the way to estimate the value of a business and /or the participations to it, using methods based on the market value of the individual assets of the business, decreasing its debts”. The entities can proceed to the re-evaluation of the tangible assets that exist at the end of the financial exercise, so that they are presented to their true value in accounting, reflecting the results of this re-evaluation in the financial reports made for that exercise. In this context, the present paper proposes the analysis of the accounting and tax treatmentforeseen by the accounting regulations, according to the European directives, and to the procedures of evaluation and re-evaluation of the tangible assets.

  9. Staged re-evaluation of non-culprit lesions in ST segment elevation myocardial infarction: a retrospective study

    OpenAIRE

    Thim, Troels; Egholm, Gro; Olesen, Kevin Kris Warnakula; Kaltoft, Anne; Terkelsen, Christian Juhl; Krusell, Lars Romer; Kristensen, Steen Dalby; Bøtker, Hans Erik; Christiansen, Evald Høj; Maeng, Michael

    2016-01-01

    Objective It remains unknown whether complete revascularisation is optimally performed in patients with ST segment elevation myocardial infarction (STEMI) during the index or at staged procedures. The aims of this study were to quantify the number of primary percutaneous coronary intervention (PCI) procedures in which non-culprit lesions needed further evaluation, to determine the consequence of the re-evaluation and to quantify adverse cardiac events during the waiting time for re-evaluation...

  10. Source-term reevaluation for US commercial nuclear power reactors: a status report

    Energy Technology Data Exchange (ETDEWEB)

    Herzenberg, C.L.; Ball, J.R.; Ramaswami, D.

    1984-12-01

    Only results that had been discussed publicly, had been published in the open literature, or were available in preliminary reports as of September 30, 1984, are included here. More than 20 organizations are participating in source-term programs, which have been undertaken to examine severe accident phenomena in light-water power reactors (including the chemical and physical behavior of fission products under accident conditions), update and reevaluate source terms, and resolve differences between predictions and observations of radiation releases and related phenomena. Results from these source-term activities have been documented in over 100 publications to date.

  11. Re-evaluation of classical prognostic factors in resectable ductal adenocarcinoma of the pancreas.

    Science.gov (United States)

    Åkerberg, Daniel; Ansari, Daniel; Andersson, Roland

    2016-07-28

    Pancreatic ductal adenocarcinoma carries a poor prognosis with annual deaths almost matching the reported incidence rates. Surgical resection offers the only potential cure. Yet, even among patients that undergo tumor resection, recurrence rates are high and long-term survival is scarce. Various tumor-related factors have been identified as predictors of survival after potentially curative resection. These factors include tumor size, lymph node disease, tumor grade, vascular invasion, perineural invasion and surgical resection margin. This article will re-evaluate the importance of these factors based on recent publications on the topic, with potential implications for treatment and outcome in patients with pancreatic cancer. PMID:27605878

  12. Source-term reevaluation for US commercial nuclear power reactors: a status report

    International Nuclear Information System (INIS)

    Only results that had been discussed publicly, had been published in the open literature, or were available in preliminary reports as of September 30, 1984, are included here. More than 20 organizations are participating in source-term programs, which have been undertaken to examine severe accident phenomena in light-water power reactors (including the chemical and physical behavior of fission products under accident conditions), update and reevaluate source terms, and resolve differences between predictions and observations of radiation releases and related phenomena. Results from these source-term activities have been documented in over 100 publications to date

  13. Association between obesity and focal nodular hyperplasia telangiectasia. 24 cases re-evaluation

    Directory of Open Access Journals (Sweden)

    Pérez Rojas, J.¹; Guarín Corredor, M. J.; Artes Martínez, M. J.¹; Vera Sempere, F. J.¹, ²; Brisa Estelles, C.¹; Huart Peris, M. C.¹; Hernández Girón, S.¹

    2013-03-01

    Full Text Available Focal nodular hyperplasia is not a true neoplasm. Itis a regenerative response of hepatocytes to a vascular abnormality.24 cases were re-evaluated and diagnosed at pathologic examination confirmed as focal nodular hyperplasia.Three of the 24 cases were reclassified as inflammatory telangiectatic adenomas with imnumorreactividadagainst amyloid A.The presence of vascular and sinusoidal dilatation,congestion, peliotic areas with signs of inflammationassociated with focal or diffuse immunoreactivity compared to Amyloid are histological signs that indicatethe presence of inflammatory telangiectatic hepatocellular adenomas, formerly classified as focal nodularhyperplasia, atypical.An increased reactivity to Amyloid and associationmetabolic syndrome characterizes inflammatory telangiectatic adenomas.

  14. A re-evaluation of Scinaia (Nemaliales, Rhodophyta) in the Azores

    Science.gov (United States)

    León-Cisneros, K.; Riosmena-Rodríguez, R.; Neto, A. I.

    2011-06-01

    The genus Scinaia in the Azores is re-evaluated based on historical and recent collections. A combination of morphological and anatomical diagnostic characters was used for species segregation, and a key for Azorean species determination is presented. Anatomical information associated to the hair development is described for the first time for the genus. The occurrence of S. furcellata and S. interrupta is confirmed for the archipelago. The presence of S. acuta is reported for the first time in the Azores, representing a spread from Australia to the N-Atlantic and specifically into the Macaronesian region. Its occurrence in the archipelago and the Canaries is discussed as a possible introduction.

  15. Reevaluation of the Thyroid Scan for the Assessment of Pathophysiologic Status of Thyroid Disease

    Energy Technology Data Exchange (ETDEWEB)

    Woo, In Sook; Nah, Jung Il; Kim, Deog Yoon [Kyunghee University College of Medicine, Seoul (Korea, Republic of)

    1991-03-15

    To diagnosis and understand the pathophysiologic status of thyroid disease, not only hormonal measurements but also thyroid scan is believed to have a unique role. Especially in the cases of the change of the thyroid function by thyroiditis, it is emphasized that thyroid scan can be helpful in differential diagnosis, Discordant results of thyroid hormone levels and thyroid scan are found in transient hyperthyroidism, or in transient hypothyroidism. We analysed and reevaluated thyroid scan to look at the importance of thyroid scan. The results are summarised as follows: 1) 80%. of hyperthyroid patients had hyperthyroidism increased RAIU with even density, they are compatible with Graves' disease. 2) 2.1% of hyperthyroid patients had normal or decreased RAIU, which are classified as high iodine turn over genuine hyperthyroidism. 3) 8.5% of hyperthyroid patients had markedly decreased RAIU at both 2 hour and 24 hour, whose pathologic processes are suggested to be heterogenous namely subacute thyroiditis, postpartum thyroiditis, Hashimoto's thyroiditis, and pamless thyroiditis. 4) 45% of hypothyroid patients had increased 24 hr RAIU, 30% of hypothyroid patients were normal, 25%, decreased. In conclusion, thyroid scan should be reevaluated its useful role to asses the pathophysiologic status of thyroid disease. Especially in cases of transient thyrotoxicosis, thyroid scan is essential to diagnose and follow up the disease process.

  16. Postmarketing Safety Surveillance and Reevaluation of Danhong Injection: Clinical Study of 30888 Cases

    Directory of Open Access Journals (Sweden)

    Xue-Lin Li

    2015-01-01

    Full Text Available Traditional Chinese medicine injections (TCMIs have played an irreplaceable role for treating some clinical emergency, severe illness, and infectious diseases in China. In recent years, the incidence rates of adverse drug reactions (ADRs of TCMIs have increased year by year. Danhong injection (DHI is one representative TCMI comprised of Danshen and Honghua for treating cardiovascular and cerebrovascular diseases in clinic. In present study, the postmarketing safety surveillance and reevaluation of DHI were reported. Total 30888 patients in 37 hospitals from 6 provinces participated in the study. The results showed that the ADR incidence rate of DHI was 3.50‰. Seventeen kinds of new adverse reactions of DHI were found. The main type of ADRs of DHI was type A (including sweating, dizziness, headache, flushing, vasodilation, eye hemorrhage, faintness, chest pain, palpitations, breathlessness, anxious, nausea, flatulence, vomiting, hypotension, hypertension, local numbness, dyspnea, joint disease, and tinnitus accounting for 57.75%. The severities of most ADRs of DHI were mild and moderate reactions accounting for 25.93% and 66.67%, respectively. The main disposition of ADRs of DHI was drug withdrawal and without any treatments. The results can provide basis for amendment and improvement of the instructions of DHI, as well as demonstration and reference for the postmarketing safety surveillance and reevaluation of other TCMIs. And the rationality, scientificity, and safety of clinical applications of TCMIs could be improved.

  17. Postmarketing Safety Surveillance and Reevaluation of Danhong Injection: Clinical Study of 30888 Cases.

    Science.gov (United States)

    Li, Xue-Lin; Tang, Jin-Fa; Li, Wei-Xia; Li, Chun-Xiao; Zhao, Tao; Zhao, Bu-Chang; Wang, Yong; Zhang, Hui; Chen, Xiao-Fei; Xu, Tao; Zhu, Ming-Jun

    2015-01-01

    Traditional Chinese medicine injections (TCMIs) have played an irreplaceable role for treating some clinical emergency, severe illness, and infectious diseases in China. In recent years, the incidence rates of adverse drug reactions (ADRs) of TCMIs have increased year by year. Danhong injection (DHI) is one representative TCMI comprised of Danshen and Honghua for treating cardiovascular and cerebrovascular diseases in clinic. In present study, the postmarketing safety surveillance and reevaluation of DHI were reported. Total 30888 patients in 37 hospitals from 6 provinces participated in the study. The results showed that the ADR incidence rate of DHI was 3.50‰. Seventeen kinds of new adverse reactions of DHI were found. The main type of ADRs of DHI was type A (including sweating, dizziness, headache, flushing, vasodilation, eye hemorrhage, faintness, chest pain, palpitations, breathlessness, anxious, nausea, flatulence, vomiting, hypotension, hypertension, local numbness, dyspnea, joint disease, and tinnitus) accounting for 57.75%. The severities of most ADRs of DHI were mild and moderate reactions accounting for 25.93% and 66.67%, respectively. The main disposition of ADRs of DHI was drug withdrawal and without any treatments. The results can provide basis for amendment and improvement of the instructions of DHI, as well as demonstration and reference for the postmarketing safety surveillance and reevaluation of other TCMIs. And the rationality, scientificity, and safety of clinical applications of TCMIs could be improved.

  18. Reevaluating the tectonic uplift of western Mount Carmel, Israel, since the middle Pleistocene

    Science.gov (United States)

    Zviely, Dov; Galili, Ehud; Ronen, Avraham; Salamon, Amos; Ben-Avraham, Zvi

    2009-03-01

    Reevaluation of geological and archaeological evidence from western Mount Carmel constrains its maximal tectonic uplift since the Middle Pleistocene. Tabun Cave, presently 45 m above sea level (asl), revealed human occupation from about 600 ka to 90 ka before present. The 25 m thick archaeological strata at Tabun are composed of laminated fine sand, silt and clays. Moreover, no marine deposits were found in Tabun or nearby caves. Since sea level in the last 600 ka reached a maximal of 5 to 10 m asl, Tabun Cave could not have been uplifted since then by more than 35 to 40 m, that is a maximal average rate of 58 to 67 mm/ka.

  19. Re-evaluation of natural food colours—State of the art

    DEFF Research Database (Denmark)

    Dusemund, B.; Parent-Massin, D.; Mortensen, Alicja;

    2011-01-01

    regarding the re-evaluation of natural food colours, including: (1) the extracts are often made from different natural sources, (2) the extracts can be made using a range of extraction solvents/methods, (3) chemical characterisation of different extracts is usually missing, (4) detailed specifications...... of the materials tested in the toxicity assays is generally unknown. Given this situation the ANS Panel considered that adequate chemical specifications for each extract are needed. Extracts derived from different sources or obtained by the use of different extraction solvents/methods can only be evaluated...... provided the chemical specifications allow a read across, or if there are toxicological data on each separate extract. If read across is not possible and if chemical specifications are limited, the safety evaluation of an extract has to be based on an adequate toxicological dataset on exactly that extract...

  20. Re-Evaluating Sexual Violence Prevention Through Bystander Education: A Latent Growth Curve Approach.

    Science.gov (United States)

    Shaw, Jessica; Janulis, Patrick

    2016-10-01

    Recently, there has been a call for more advanced analytic techniques in violence against women research, particularly in community interventions that use longitudinal designs. The current study re-evaluates experimental evaluation data from a sexual violence bystander intervention program. Using an exploratory latent growth curve approach, we were able to model the longitudinal growth trajectories of individual participants over the course of the entire study. Although the results largely confirm the original evaluation findings, the latent growth curve approach better fits the demands of "messy" data (e.g., missing data, varying number of time points per participant, and unequal time spacing within and between participants) that are frequently obtained during a community-based intervention. The benefits of modern statistical techniques to practitioners and researchers in the field of sexual violence prevention, and violence against women more generally, are further discussed. PMID:25888503

  1. Reevaluating the "subjective weathering" hypothesis: subjective aging, coping resources, and the stress process.

    Science.gov (United States)

    Benson, Janel E

    2014-03-01

    The subjective weathering model contends that subjective aging is a key component of the stress process. This study reevaluates and extends this model by considering how adaptive capacities influence subjective aging and depressive symptoms in late adolescence and young adulthood. Using longitudinal data from the National Longitudinal Study of Adolescent Health (n = 7,230), I investigate how earlier stressors and coping resources contribute to older age identities (ages 18-22) and how these self-perceptions influence subsequent depressive symptoms (ages 25-29). The results show that subjective weathering alone does not lead to depressive symptoms; the critical issue is the level of psychosocial maturity that accompanies an older age identity. Those with high levels of psychosocial maturity, regardless of subjective age, were least likely to exhibit depressive symptoms. These results demonstrate that psychosocial maturity is an important adaptive resource that can shield young adults from the negative effects of "subjective weathering" or growing up fast.

  2. Gastric pseudolipomatosis, usual or unusual? Re-evaluation of 909 endoscopic gastric biopsies

    Institute of Scientific and Technical Information of China (English)

    Murat Alper; Yusuf Akcan; Olcay K Belenli; Selma Cukur; Kamuran A Aksoy; Mazlume Suna

    2003-01-01

    Microvesicular pneumatosis intestinalis, also called "pseudolipomatosis" for resembling fatty infiltration, is characterized by the presence of small gas voids in the gastrointestinal wall, especially in mucosa. These voids are not lined with epithelia. There are few reported cases about colon, duodenum and skin. Because there is only one case report about pseudolipomatosis in the stomach, we reevaluated 909 endoscopic biopsies taken from gastric corpus to check the presence of pseudolipomatosis. We determined pseudolipomatosis foci in 3 percent (n=27) of biopsies. In two cases there were pseudolipomatosis foci in endoscopic biopsies having otherwise normal histologic findings, while there were pseudolipomatosis foci in endoscopic biopsies of 25 patients with gastritis. H pylori was found in 85 % of biopsies having pseudolipomatosis foci. In this study, we presented some histopathologic characteristics of pseudolipomatosis seen in gastric mucosa.

  3. Scientific Opinion on the re-evaluation of anthocyanins (E 163 as a food additive

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS

    2013-04-01

    Full Text Available Following a request from the European Commission to the European Food Safety Authority (EFSA, the Scientific Panel on Food Additives and Nutrient Sources added to Food (ANS was asked to provide a scientific opinion re-evaluating the safety of anthocyanins (E 163. The Panel concluded that the currently available toxicological database was inadequate to establish a numerical ADI for anthocyanins. For anthocyanins extracted from edible fruits and vegetables by aqueous processes, changes in composition would not be expected. The Panel concluded that provided exposure from use as a food additive was comparable to that from the diet the underlying conclusion in the 1975 SCF opinion that such food additives derived from natural sources would still apply. The majority of data are on aqueous grape skin extract (GSKE and blackcurrant extracts and the Panel considers that exposures estimated from current uses and use levels these extracts are unlikely to be of safety concern. The Panel recommends that the specifications for E 163 should be modified to reflect this conclusion. For anthocyanins extracted from other sources and/or using non-aqueous extraction methods the absence of characterisation does not allow verification that this conclusion in the 1975 SCF opinion could be applied. The Panel noted that for some extracts it had proven possible to assess a group based on toxicological and compositional data on representative samples across the range of extracts. The Panel concluded that refined exposure estimates of anthocyanins used as a food additive were higher than dietary intakes and that these did not include intakes from colouring foods. Therefore the Panel would recommend that appropriate characterisation and toxicological data should be required to permit a further re-evaluation of anthocyanins including comparative data on anthocyanins (E 163 produced by aqueous extraction.

  4. Re-evaluation of Non-regulatory Asbestos Group Minerals for Regulatory Agencies

    Science.gov (United States)

    Dogan, M.; Dogan, A.

    2013-05-01

    There are established rules and regulations for some asbestos group minerals - amphibole group minerals of actinolite, amosite, anthophyllite, crocidolite, tremolite; and serpentine group minerals of chrysotile- called "regulatory". There are also "non-regulatory" naturally occurring asbestos (NOA) group minerals as constituent of rocks and soil, including richterite, winchite, fluoro-edenite, balangeroite, carlosturanite, gageite, arfvedsonite, and magnesio-arfvedsonite. Strong evidences for carcinogenicity of these NOA minerals in later cohorts of cancer patients demonstrated the risks associated with these minerals. In addition, although the chrysotile asbestos regulated by some organizations such as WHO, World Trade Organization, United Nations, US EPA, International Labour Organization, and EU Countries; however, controversies still continue surrounding the use of chrysotile. Determinations of polymineralic fibrous veins, mixed particles, amphibole cleavage fragments, and genetic predisposition are also important issues (i.e. Dogan et al., 2006).Therefore, accurate characterizations of chemical composition, morphology, structure, and defects are necessary in order to find out mechanism(s) of carcinogenicity of all asbestos group minerals. Calculation methods of chemical composition are still under debate because of assumption of no vacancies at any sites and intergrowth of minerals. Substitution(s) may cause deviations from the ideal chemical formula and wide variations in chemical compositions. Detail morphological and chemical quantification of individual asbestos group minerals in micro- and nano-scale may help to evaluate its true carcinogenetic mechanism(s), and consequently prevention and possibly treatment of related diseases. we propose that nonregulatory asbestos minerals and the chrysotile should be re-evaluated. The amount of fibers inhaled, in terms of weight percent and number, need also be re-evaluated by mineralogists. Finally, Regulatory

  5. Reevaluation of dating results for some {sup 14}C - AMS applications on the basis of the new calibration curves available

    Energy Technology Data Exchange (ETDEWEB)

    Macario, K.D.; Gomes, P.R.S.; Anjos, R.M. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Inst. de Fisica

    2007-03-15

    In this paper we describe briefly some characteristics of the Accelerator Mass Spectrometry (AMS) technique and the need of corrections in the radiocarbon ages by specific calibration curves. Then we discuss previous results of some Brazilian projects where radiocarbon AMS had been applied in order to reevaluate the dates obtained on the basis of the new calibration curves available. (author)

  6. Re-evaluation of 40Ca(n, tot) Cross Sections and Covariance up to 20 MeV

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Yue; XU; Rui-rui; LIU; Ting-jin

    2012-01-01

    <正>Based on the last evaluation on 40Ca(n, tot) cross sections and covariance in 2011, the new covariance evaluation is given, improved some deficiency of last work. In this work the commended cross sections are reserved and the covariance is re-evaluated. The

  7. 76 FR 29021 - Written Re-Evaluation and Record of Decision for the Final Environmental Impact Statement for the...

    Science.gov (United States)

    2011-05-19

    ... Environmental Impact Statement for the Relocation of the Panama City-Bay County International Airport (2006... Federal Aviation Administration Written Re-Evaluation and Record of Decision for the Final Environmental Impact Statement for the Relocation of the Panama City- Bay County International Airport AGENCY: FAA,...

  8. Reevaluation of the macroseismic effects of the 1887 Sonora, Mexico earthquake and its magnitude estimation

    Science.gov (United States)

    Suárez, Gerardo; Hough, Susan E.

    2008-01-01

    The Sonora, Mexico, earthquake of 3 May 1887 occurred a few years before the start of the instrumental era in seismology. We revisit all available accounts of the earthquake and assign Modified Mercalli Intensities (MMI), interpreting and analyzing macroseismic information using the best available modern methods. We find that earlier intensity assignments for this important earthquake were unjustifiably high in many cases. High intensity values were assigned based on accounts of rock falls, soil failure or changes in the water table, which are now known to be very poor indicators of shaking severity and intensity. Nonetheless, reliable accounts reveal that light damage (intensity VI) occurred at distances of up to ~200 km in both Mexico and the United States. The resulting set of 98 reevaluated intensity values is used to draw an isoseismal map of this event. Using the attenuation relation proposed by Bakun (2006b), we estimate an optimal moment magnitude of Mw7.6. Assuming this magnitude is correct, a fact supported independently by documented rupture parameters assuming standard scaling relations, our results support the conclusion that northern Sonora as well as the Basin and Range province are characterized by lower attenuation of intensities than California. However, this appears to be at odds with recent results that Lg attenuation in the Basin and Range province is comparable to that in California.

  9. Re-evaluation and updating of the seismic hazard of Lebanon

    Science.gov (United States)

    Huijer, Carla; Harajli, Mohamed; Sadek, Salah

    2016-01-01

    This paper presents the results of a study undertaken to evaluate the implications of the newly mapped offshore Mount Lebanon Thrust (MLT) fault system on the seismic hazard of Lebanon and the current seismic zoning and design parameters used by the local engineering community. This re-evaluation is critical, given that the MLT is located at close proximity to the major cities and economic centers of the country. The updated seismic hazard was assessed using probabilistic methods of analysis. The potential sources of seismic activities that affect Lebanon were integrated along with any/all newly established characteristics within an updated database which includes the newly mapped fault system. The earthquake recurrence relationships of these sources were developed from instrumental seismology data, historical records, and earlier studies undertaken to evaluate the seismic hazard of neighboring countries. Maps of peak ground acceleration contours, based on 10 % probability of exceedance in 50 years (as per Uniform Building Code (UBC) 1997), as well as 0.2 and 1 s peak spectral acceleration contours, based on 2 % probability of exceedance in 50 years (as per International Building Code (IBC) 2012), were also developed. Finally, spectral charts for the main coastal cities of Beirut, Tripoli, Jounieh, Byblos, Saida, and Tyre are provided for use by designers.

  10. Re-Evaluation of Clinical Dementia Diagnoses with Pittsburgh Compound B Positron Emission Tomography

    Directory of Open Access Journals (Sweden)

    M. Degerman Gunnarsson

    2013-12-01

    Full Text Available Objectives: There is an overlap regarding Pittsburgh compound B (PIB retention in patients clinically diagnosed as Alzheimer's disease (AD and non-AD dementia. The aim of the present study was to investigate whether there are any differences between PIB-positive and PIB-negative patients in a mixed cohort of patients with neurodegenerative dementia of mild severity regarding neuropsychological test performance and regional cerebral glucose metabolism measured with [18F]fluoro-2-deoxy-D-glucose (FDG positron emission tomography (PET. Methods: Eighteen patients clinically diagnosed as probable AD or frontotemporal dementia were examined with PIB PET, FDG PET and neuropsychological tests and followed for 5-9 years in a clinical setting. Results: The PIB-positive patients (7 out of 18 had slower psychomotor speed and more impaired visual episodic memory than the PIB-negative patients; otherwise performance did not differ between the groups. The initial clinical diagnoses were changed in one third of the patients (6 out of 18 during follow-up. Conclusions: The subtle differences in neuropsychological performance, the overlap of hypometabolic patterns and clinical features between AD and non-AD dementia highlight the need for amyloid biomarkers and a readiness to re-evaluate the initial diagnosis.

  11. Adaptively Reevaluated Bayesian Localization (ARBL): A novel technique for radiological source localization

    International Nuclear Information System (INIS)

    We present a novel technique for the localization of radiological sources in urban or rural environments from an aerial platform. The technique is based on a Bayesian approach to localization, in which measured count rates in a time series are compared with predicted count rates from a series of pre-calculated test sources to define likelihood. This technique is expanded by using a localized treatment with a limited field of view (FOV), coupled with a likelihood ratio reevaluation, allowing for real-time computation on commodity hardware for arbitrarily complex detector models and terrain. In particular, detectors with inherent asymmetry of response (such as those employing internal collimation or self-shielding for enhanced directional awareness) are leveraged by this approach to provide improved localization. Results from the localization technique are shown for simulated flight data using monolithic as well as directionally-aware detector models, and the capability of the methodology to locate radioisotopes is estimated for several test cases. This localization technique is shown to facilitate urban search by allowing quick and adaptive estimates of source location, in many cases from a single flyover near a source. In particular, this method represents a significant advancement from earlier methods like full-field Bayesian likelihood, which is not generally fast enough to allow for broad-field search in real time, and highest-net-counts estimation, which has a localization error that depends strongly on flight path and cannot generally operate without exhaustive search

  12. The carcinogenic effects of aspartame: The urgent need for regulatory re-evaluation.

    Science.gov (United States)

    Soffritti, Morando; Padovani, Michela; Tibaldi, Eva; Falcioni, Laura; Manservisi, Fabiana; Belpoggi, Fiorella

    2014-04-01

    Aspartame (APM) is an artificial sweetener used since the 1980s, now present in >6,000 products, including over 500 pharmaceuticals. Since its discovery in 1965, and its first approval by the US Food and Drugs Administration (FDA) in 1981, the safety of APM, and in particular its carcinogenicity potential, has been controversial. The present commentary reviews the adequacy of the design and conduct of carcinogenicity bioassays on rodents submitted by G.D. Searle, in the 1970s, to the FDA for market approval. We also review how experimental and epidemiological data on the carcinogenic risks of APM, that became available in 2005 motivated the European Commission (EC) to call the European Food and Safety Authority (EFSA) for urgent re-examination of the available scientific documentation (including the Searle studies). The EC has further requested that, if the results of the evaluation should suggest carcinogenicity, major changes must be made to the current APM specific regulations. Taken together, the studies performed by G.D. Searle in the 1970s and other chronic bioassays do not provide adequate scientific support for APM safety. In contrast, recent results of life-span carcinogenicity bioassays on rats and mice published in peer-reviewed journals, and a prospective epidemiological study, provide consistent evidence of APM's carcinogenic potential. On the basis of the evidence of the potential carcinogenic effects of APM herein reported, a re-evaluation of the current position of international regulatory agencies must be considered an urgent matter of public health.

  13. Adaptively Reevaluated Bayesian Localization (ARBL): A novel technique for radiological source localization

    Science.gov (United States)

    Miller, Erin A.; Robinson, Sean M.; Anderson, Kevin K.; McCall, Jonathon D.; Prinke, Amanda M.; Webster, Jennifer B.; Seifert, Carolyn E.

    2015-06-01

    We present a novel technique for the localization of radiological sources in urban or rural environments from an aerial platform. The technique is based on a Bayesian approach to localization, in which measured count rates in a time series are compared with predicted count rates from a series of pre-calculated test sources to define likelihood. This technique is expanded by using a localized treatment with a limited field of view (FOV), coupled with a likelihood ratio reevaluation, allowing for real-time computation on commodity hardware for arbitrarily complex detector models and terrain. In particular, detectors with inherent asymmetry of response (such as those employing internal collimation or self-shielding for enhanced directional awareness) are leveraged by this approach to provide improved localization. Results from the localization technique are shown for simulated flight data using monolithic as well as directionally-aware detector models, and the capability of the methodology to locate radioisotopes is estimated for several test cases. This localization technique is shown to facilitate urban search by allowing quick and adaptive estimates of source location, in many cases from a single flyover near a source. In particular, this method represents a significant advancement from earlier methods like full-field Bayesian likelihood, which is not generally fast enough to allow for broad-field search in real time, and highest-net-counts estimation, which has a localization error that depends strongly on flight path and cannot generally operate without exhaustive search.

  14. Lessons learned from the seismic reevaluation of San Onofre Nuclear Generating Station, Unit 1

    International Nuclear Information System (INIS)

    A seismic reevaluation program was conducted for the San Onofre Nuclear Generating Station, Unit No. 1 (SONGS 1). SEP was created by the NRC to provide (1) an assessment of the significance of differences between current technical positions on safety issues and those that existed when a particular plant was licensed, (2) a basis for deciding on how these differences should be resolved in an integrated plant review, and (3) a documented evaluation of plant safety. The Systematic Evaluation Program (SEP) seismic review for SONGS 1 was exacerbated by the results of an evaluation of an existing capable fault near the site during the design review for Units 2 and 3, which resulted in a design ground acceleration of 0.67g. Southern California Edison Company (SCE), the licensee for SONGS 1, realized that a uniform application of existing seismic criteria and methods would not be feasible for the upgrading of SONGS 1 to such a high seismic requirement. Instead, SCE elected to supplement existing seismic criteria and analysis methods by developing criteria and methods closer to the state of the art in seismic evaluation techniques

  15. Reevaluation of thermonuclear reaction rate of 50Fe(p,gamma)51Co

    CERN Document Server

    Zhang, L P; Chai, W D; Hou, S Q; Zhang, L Y

    2016-01-01

    The thermonuclear rate of the 50Fe(p,gamma)51Co reaction in the Type I X-ray bursts (XRBs) temperature range has been reevaluated based on a recent precise mass measurement at CSRe lanzhou, where the proton separation energy Sp=142+/-77 keV has been determined firstly for the 51Co nucleus. Comparing to the previous theoretical predictions, the experimental Sp value has much smaller uncertainty. Based on the nuclear shell model and mirror nuclear structure information, we have calculated two sets of thermonuclear rates for the 50Fe(p,gamma)51Co reaction by utilizing the experimental Sp value. It shows that the statistical-model calculations are not ideally applicable for this reaction primarily because of the low density of low-lying excited states in 51Co. In this work, we recommend that a set of new reaction rate based on the mirror structure of 51Cr should be incorporated in the future astrophysical network calculations.

  16. Seismic re-evaluation of piping systems of heavy water plant, Kota

    CERN Document Server

    Mishra, R; Soni, R S; Venkat-Raj, V

    2002-01-01

    Heavy Water Plant, Kota is the first indigenous heavy water plant built in India. The plant started operation in the year 1985 and it is approaching the completion of its originally stipulated design life. In view of the excellent record of plant operation for the past so many years, it has been planned to carry out various exercises for the life extension of the plant. In the first stage, evaluation of operation stresses was carried out for the process critical piping layouts and equipment, which are connected with 25 process critical nozzle locations, identified based on past history of the plant performance. Fatigue life evaluation has been carried out to fmd out the Cumulative Usage Factor, which helps in arriving at a decision regarding the life extension of the plant. The results of these exercises have been already reported separately vide BARC/200I /E/O04. In the second stage, seismic reevaluation of the plant has been carried out to assess its ability to maintain its integ:rity in case of a seismic e...

  17. Reevaluating Metabolism in Alzheimer's Disease from the Perspective of the Astrocyte-Neuron Lactate Shuttle Model

    Directory of Open Access Journals (Sweden)

    Jordan T. Newington

    2013-01-01

    Full Text Available The conventional view of central nervous system (CNS metabolism is based on the assumption that glucose is the main fuel source for active neurons and is processed in an oxidative manner. However, since the early 1990s research has challenged the idea that the energy needs of nerve cells are met exclusively by glucose and oxidative metabolism. This alternative view of glucose utilization contends that astrocytes metabolize glucose to lactate, which is then released and taken up by nearby neurons and used as a fuel source, commonly known as the astrocyte-neuron lactate shuttle (ANLS model. Once thought of as a waste metabolite, lactate has emerged as a central player in the maintenance of neuronal function and long-term memory. Decreased neuronal metabolism has traditionally been viewed as a hallmark feature of Alzheimer's disease (AD. However, a more complex picture of CNS metabolism is emerging that may provide valuable insight into the pathophysiological changes that occur during AD and other neurodegenerative diseases. This review will examine the ANLS model and present recent evidence highlighting the critical role that lactate plays in neuronal survival and memory. Moreover, the role of glucose and lactate metabolism in AD will be re-evaluated from the perspective of the ANLS.

  18. Bad taxonomy can kill : molecular reevaluation of Unio mancus Lamarck, 1819 (Bivalvia : Unionidae) and its accepted subspecies

    OpenAIRE

    Prie V.; Puillandre N.; Bouchet P.

    2012-01-01

    The conservation status of European unionid species rests on the scientific knowledge of the 1980s, before the current revival of taxonomic reappraisals based on molecular characters. The taxonomic status of Unio mancus Lamarck, 1819, superficially similar to Unio pictorum (Linnaeus, 1758) and often synonymized with it, is re-evaluated based on a random sample of major French drainages and a systematic sample of historical type localities. We confirm the validity of U. mancus as a distinct sp...

  19. Reevaluation of Fatty Acid Receptor 1 as a Drug Target for the Stimulation of Insulin Secretion in Humans

    OpenAIRE

    Wagner, Robert; Kaiser, Gabriele; Gerst, Felicia; Christiansen, Elisabeth; Due-Hansen, Maria E.; Grundmann, Manuel; Machicao, Fausto; Peter, Andreas; Kostenis, Evi; Ulven, Trond; Fritsche, Andreas; Häring, Hans-Ulrich; Ullrich, Susanne

    2013-01-01

    The role of free fatty acid receptor 1 (FFAR1/GPR40) in glucose homeostasis is still incompletely understood. Small receptor agonists stimulating insulin secretion are undergoing investigation for the treatment of type 2 diabetes. Surprisingly, genome-wide association studies did not discover diabetes risk variants in FFAR1. We reevaluated the role of FFAR1 in insulin secretion using a specific agonist, FFAR1-knockout mice and human islets. Nondiabetic individuals were metabolically phenotype...

  20. Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin.

    Science.gov (United States)

    Hard, Gordon C; Seely, John Curtis; Betz, Laura J; Hayashi, Shim-Mo

    2007-04-01

    Renal histopathology in the most recent 2-year carcinogenicity bioassay of quercetin, in Fischer 344 rats, was re-evaluated in an attempt to determine a mode of action underlying a small increase in renal tubule tumors reported in the males (). The re-evaluation confirmed the reported increase in renal tumors in mid- and high-dose males, including a single carcinoma in a high-dose male, as well as an exacerbation of spontaneous, chronic progressive nephropathy (CPN) in male rats only. The re-evaluation also showed that there were no cellular alterations in the kidney indicative of chemical toxicity at 6 months, 15 months, or 2 years. The evidence linked the occurrence of the predominant basophilic adenomas and foci of atypical tubule hyperplasia (ATH) with the exacerbation of CPN to advanced grades of severity, supporting a mode of action involving quercetin interaction with CPN. This mode of action represents a secondary mechanism for renal tumor development, with no relevance for extrapolation to humans. In addition, the single carcinoma present in the high-dose males, along with 4 other lesions ranging from ATH to adenoma in male and female groups, were considered to have a unique phenotype associated previously with neoplasms of spontaneous and familial origin.

  1. Re-evaluation of the macroseismic effects produced by the March 4, 1977, strong Vrancea earthquake in Romanian territory

    Directory of Open Access Journals (Sweden)

    Aurelian Pantea

    2013-04-01

    Full Text Available In this paper, the macroseismic effects of the subcrustal earthquake in Vrancea (Romania that occurred on March 4, 1977, have been re-evaluated. This was the second strongest seismic event that occurred in this area during the twentieth century, following the event that happened on November 10, 1940. It is thus of importance for our understanding of the seismicity of the Vrancea zone. The earthquake was felt over a large area, which included the territories of the neighboring states, and it produced major damage. Due to its effects, macroseismic studies were developed by Romanian researchers soon after its occurrence, with foreign scientists also involved, such as Medvedev, the founder of the Medvedev-Sponheuer-Karnik (MSK seismic intensity scale. The original macroseismic questionnaires were re-examined, to take into account the recommendations for intensity assessments according to the MSK-64 macroseismic scale used in Romania. After the re-evaluation of the macroseismic field of this earthquake, the intensity dataset was obtained for 1,620 sites in Romanian territory. The re-evaluation was necessary as it has confirmed that the previous macroseismic map was underestimated. On this new map, only the intensity data points are plotted, without tracing the isoseismals.

  2. 40 CFR 33.209 - Can EPA re-evaluate the MBE or WBE status of an entity after EPA certifies it to be an MBE or WBE?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Can EPA re-evaluate the MBE or WBE status of an entity after EPA certifies it to be an MBE or WBE? 33.209 Section 33.209 Protection of... EPA re-evaluate the MBE or WBE status of an entity after EPA certifies it to be an MBE or WBE? (a)...

  3. Reevaluation of the digestible lysine requirement for broilers based on genetic potential

    Directory of Open Access Journals (Sweden)

    Juliano Cesar De Paula Dorigam

    2014-06-01

    Full Text Available Broiler strains available in the poultry industry present different requirements for dietary lysine due to their different growth potentials as a result of their genetic makeup. This study aimed to determine the model parameters for maximum nitrogen retention (NRmaxT, the nitrogen maintenance requirement (NMR and the efficiency of lysine utilization (bc-1 to reevaluate the lysine (Lys requirements of male and female broilers. Nitrogen balance trials were performed during three periods (I: 6-21 days, II: 22-37 days, and III: 38-53 days. Seven treatments were used for males and females; the treatments consisted of seven diets with protein levels ranging from 61 to 364 g kg-1 dry matter, with Lys being limiting in the dietary nitrogen (4.91 g of Lys in 16 g of N. Nitrogen intake (NI, excretion (NEX, deposition (ND, ND=NI-NEX and retention (NR, NR=ND+NMR values were obtained. The NMR was represented by the exponential relationship between NEX and NI. The NRmax T and bc-1 were estimated by the exponential fit between ND and NI. The NRmax T, bc-1, and NMR values were combined in a model to estimate Lys intake by simulating different percentages of the NRmaxT. The Lys intake estimates were 581, 1,538, and 2,171 mg day-1 for males and 512, 1,340, and 1674 mg day-1 for females during periods I, II, and III, respectively. Due to the flexibility of the model, it is possible to calculate the Lys intake for percentages of NR in the range of practical performance data.

  4. Re-evaluation of the amplitude-force relationship of trunk muscles.

    Science.gov (United States)

    Huebner, Agnes; Faenger, Bernd; Scholle, Hans-Christoph; Anders, Christoph

    2015-04-13

    Amplitude-force relationships of major trunk muscles are established in terms of curve characteristics, but up to now were not normalized with respect to maximum voluntary contraction (MVC) force levels. The study therefore aims at a re-evaluation of trunk muscle amplitude-force relationship data according to MVC. Surface EMG of five major trunk muscles was taken from 50 healthy subjects of both sexes (age 20-40 years). All tasks were performed in a device where submaximal loads on the trunk were applied by gradually tilting the subjects in sagittal plane to horizontal position. MVC flexion and extension forces were determined in upright position using an additional harness over the subject's shoulders. Furthermore, the subject's upper body mass (UBM) was obtained during forward tilt to horizontal. MVC to UBM ratio was calculated, corrected by the actual tilt angle, and these linearly estimated values compared with the measured relative values according to MVC. All abdominal muscles confirmed the known non-linear amplitude-force relationship. At low load levels the linearly estimated values overestimated the measured ones and, at higher load levels, underestimated the true stress levels considerably. Back muscles confirmed the known linear curve shape, but for the longissimus muscle at L1 level measured data was always below estimated values. With increasing load, muscular stress of abdominal muscles changes from overestimated towards considerably underestimated values if expected stress levels are based on linear interpolation. Major back muscles' activation levels are nearly linear, but the amplitude-force relationship values seem overestimated for longissimus.

  5. A Re-Evaluation of the Relativistic Redshift on Frequency Standards at NIST, Boulder, Colorado, USA

    Science.gov (United States)

    Pavlis, N. K.; Weiss, M. A.

    2014-12-01

    Primary frequency standards that realize the definition of the second based on the Caesium (Cs) atom are used to steer International Atomic Time. According to the theory of relativity, their frequency should be adjusted to that at which these would operate, if located on the geoid. Current best standards for the current definition of the second are approaching uncertainties of one part in 1016. Optical frequency standards however are now reaching uncertainties of few parts in 1018 and are expected to lead to a new definition of the second. Their performance requires centimetre-level geoid accuracy, in order to calculate accurately the redshift frequency offset necessary for their inter-comparison. We re-evaluated the relativistic redshift of the frequency standards at NIST in Boulder, Colorado, USA, based on a recent precise GPS survey of several benchmarks on the roof of the building where these are housed, and on global and local geoid models supported by data from the GRACE and GOCE missions, including EGM2008, USGG2009, and USGG2012. We also evaluated the redshift offset based on the published NAVD88 geopotential number of the levelling benchmark Q407, after estimating the bias of the NAVD88 datum at our specific location. We present and discuss the results that we obtained using different methods, and provide our current estimate of the redshift offset and of its accuracy, considering the main error sources contributing to the total error budget. We compare our current estimates to those published by Pavlis and Weiss in 2003, using the data and models that were available at that time. We also discuss the prospects of using inter-connected ultra-precise frequency standards for the direct determination of geoid height differences, which may provide in the not-too-distant future an alternative approach for the establishment of vertical datums and the independent verification of the accuracy of global and local geoid models.

  6. Cardioprotective effects of diltiazem reevaluated by a novel myocardial ischemic model in Chinese miniature swine

    Institute of Scientific and Technical Information of China (English)

    Jian-xun LIU; Zhen YU; Xin-zhi LI; Jian-hua FU; Xiao-hong SHANG; Ai-guo YAN; Yue SHI; Yan-lei MA

    2007-01-01

    Aim: To develop a new model of myocardial ischemia in Chinese miniature swine and reevaluate the cardioprotective effects of diltiazem. Methods: Myocardial ischemia was induced by injecting self-embolus into the left anterior descending(LAD) coronary artery in qualified miniature swine. Diltiazem (5 mg.kg-1.d-1) was orally administered to the swine by mixing into normal pig diet from 1 to 6 d after self-embolus injection. The coronary angiography, 30 point body surface electro-cardiogram (BS-ECG), hemodynamics, biochemistry, quantitative histology and pathohistology were determined 6 d after self-embolus injection. Results: Embo-lization occurred in the LAD coronary artery of the Chinese miniature swine in-jected by self-embolus. There were significant myocardial ischemia and large cardiac muscle infarction in the Chinese miniature swine, which were accompa-nied with increased BS-ECG, decreased hemodynamic indexes of the cardiac output,cardiac index, left cardiac work and left cardiac work index, and increased systemic vascular resistance index. Pathohistological analysis revealed myocardial degen-eration, necrosis, fibrosis, inflammatory cell infiltration and granulation tissue hyperblastosis (n=6). Diltiazem diminished the extent of the LAD embolism, ame-liorated myocardial ischemia, improved the hemodynamic indexes, increased the plasma superoxide dismutase activity, decreased the plasma malondialdehyde content, narrowed the myocardial ischemic area and weakened the pathohistological damage in the cardiac muscle (n=6). Conclusion: Myocardial ischemia induced by injecting self-embolus into the LAD coronary artery in Chinese miniature swine is quite close to clinical pathophysiological conditions. Diltiazem is effective to inhibit the myocardial ischemia and restore the heart function in this novel model.

  7. Abdominal pain among children re-evaluation of a diagnostic algorithm

    Institute of Scientific and Technical Information of China (English)

    Hona Zhou; Yi-Chen Chen; Jin-Zhe Zhana

    2002-01-01

    AIM: To re-evaluate the algorithm that has been used forover 40 years for diagnosis of acute abdominal pain amongchildren.METHODS: Among the 937 cases admitted to the surgicalemergency ward in 2000, 656 cases of acute appendicitiswere studied to evaluate the usefulness of the presentalgorithm for its colculated accuracy, false positive and falsenegative rates, the sensitivity and specificity in the instantdiagnosis of various types of acute appendicitis in differentage groups.The algorithm used was established in 1958and revisedror this study in 1999. It includes a 3-step analysisof clinical presentations, i.e.: firstly, a diagnosis of surgicalpain by definite organic abdominal signs; then a diagnosisof the subgroup of surgical condition by special signs; andfinally the diagnosis of the present disease by specific signs.A footnote describes a "comparative technique″ of abdominalexamination in non-cooperative children.RESULTS: The general accuracy of diagnosis was 92.8 %,overall mortality 0.1% among 973 cases of abdominal painin 2000. 373 attending surgeons and 241 residents includingtrainees joined the diagnosis and treatment with noremarkable difference in the results. The incidence of acuteappendicitis, 656 in 973 cases, was 67.4 % representingthe majority of abdominal pain. In the series of 656 cases,the accuracy of diagnosis of acute appendidtis was 93.6 %,false positive 6.4 %, false negative 0.9 %, sensitivity at firstvisit 82.7 %, specificity for appendicitis 98.0 %, no death ordocumentary complication.CONCLUSION: The present algorithm used for diagnosisof acute abdominal pain is effective and preferable inreducing misdiagnosis and maltreatment at emergency. Theuse of some modern technology should be further explored.

  8. Re-evaluation of internal exposure from the Chernobyl accident to the Czech population

    Energy Technology Data Exchange (ETDEWEB)

    Malatova, I.; Skrkal, J. [National Radiation Protection Institute, Srobarova (Czech Republic)

    2006-07-01

    Doses from internal and external exposure due to the Chernobyl accident to the Czech population were estimated early in 1986. Later on, with more eimental results, doses from internal exposure were calculated more precisely. The initial predictions were rather conservative leading thus to higher doses than it appeared one year later. Monitoring of the environment, food chain and monitoring of internal contamination has been performed on the whole territory of the country since 1986 up to present time and has thus enabled reevaluation of the original estimates and also prediction of doses in future. This paper is focused mainly on evaluation of in vivo measurements of people. Use of the sophisticate software I.M.B.A. Professional Plus led to new estimation of committed effective doses and calculated inhalation intakes of radionuclides lead to estimation of content of radionuclides in the air. Ingestion intakes were also evaluated and compared with estimates from the results of measurements of food chain. Generally, the doses from the Chernobyl accident to the Czech population were low; however, as a few radionuclides have been measurable in environment, food chain and human body (137 Cs up to present), it is a unique chance for studying behaviour of radionuclides in the biosphere. Experience and conclusions which follow from the monitoring of the Chernobyl accident are unique for running and development of monitoring networks. Re evaluation of internal doses to the Czech population from the Chernobyl accident, using alternative approach, gave generally smaller doses than original estimation; still, the difference was not significant. It was shown that the doses from inhalation of 131 I and 137 Cs were greater than originally estimated, whereas doses from ingestion intake were lower than the originally estimated ones. (authors)

  9. A reevaluation of the morphology, paleoecology, and phylogenetic relationships of the enigmatic walrus Pelagiarctos.

    Directory of Open Access Journals (Sweden)

    Robert W Boessenecker

    Full Text Available BACKGROUND: A number of aberrant walruses (Odobenidae have been described from the Neogene of the North Pacific, including specialized suction-feeding and generalist fish-eating taxa. At least one of these fossil walruses has been hypothesized to have been a specialized predator of other marine mammals, the middle Miocene walrus Pelagiarctos thomasi from the Sharktooth Hill Bonebed of California (16.1-14.5 Ma. METHODOLOGY/PRINCIPAL FINDINGS: A new specimen of Pelagiarctos from the middle Miocene "Topanga" Formation of southern California (17.5-15 Ma allows a reassessment of the morphology and feeding ecology of this extinct walrus. The mandibles of this new specimen are robust with large canines, bulbous premolars with prominent paraconid, metaconid, hypoconid cusps, crenulated lingual cingula with small talonid basins, M₂ present, double-rooted P₃-M₁, single-rooted P₁ and M₂, and a P₂ with a bilobate root. Because this specimen lacks a fused mandibular symphysis like Pelagiarctos thomasi, it is instead referred to Pelagiarctos sp. This specimen is more informative than the fragmentary holotype of Pelagiarctos thomasi, permitting Pelagiarctos to be included within a phylogenetic analysis for the first time. Analysis of a matrix composed of 90 cranial, dental, mandibular and postcranial characters indicates that Pelagiarctos is an early diverging walrus and sister to the late Miocene walrus Imagotaria downsi. We reevaluate the evidence for a macropredatory lifestyle for Pelagiarctos, and we find no evidence of specialization towards a macrophagous diet, suggesting that Pelagiarctos was a generalist feeder with the ability to feed on large prey. CONCLUSIONS/SIGNIFICANCE: This new specimen of Pelagiarctos adds to the knowledge of this problematic taxon. The phylogenetic analysis conclusively demonstrates that Pelagiarctos is an early diverging walrus. Pelagiarctos does not show morphological specializations associated with macrophagy

  10. Scientific Opinion on the re-evaluation of candelilla wax (E 902 as a food additive

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS

    2012-11-01

    Full Text Available The Panel on Food Additives and Nutrient Sources added to Food (ANS delivers a scientific opinion re-evaluating the safety of candelilla wax (E 902. Candelilla wax (E 902 is authorised in the EU as a food additive as a glazing agent. It has been evaluated by the Scientific Committee on Food (SCF and by the Joint FAO/WHO Expert Committee on Food Additives (JECFA. The JECFA and the SCF did not establish an Acceptable Daily Intake (ADI but considered the use of candelilla wax as a glazing agent acceptable. Candelilla wax is obtained from leaves of candelilla plants Euphorbia antisyphilitica found in semi-desert regions. It is a complex mixture composed of wax hydrocarbons, wax, resin esters, lactones, free wax resin alcohols, and free wax resin acids. The Panel considered that absorption of candelilla wax is expected to be low, and that upon absorption the components would be incorporated into normal metabolic pathways. The Panel noted that there were limited data comparing the composition of the candelilla wax tested with the specification of the food additive. However the Panel considered that the materials tested were likely to be broadly similar in composition to the food additive. Overall, the Panel considered that the available data suggest that candelilla wax is not genotoxic. The Panel considered that long-term toxicity data on candelilla wax were lacking and therefore did not establish an ADI. However, the Panel noted that available toxicity studies consistently reported no findings associated with intake of the main components constituting candelilla wax. Furthermore, consideration of the exposure estimates to candelilla wax, using the Maximum Permitted Level (MPL of carnauba wax, indicated sufficient margins of safety. This allowed the Panel to conclude that the use of candelilla wax as a food additive with the currently authorised uses would not be of safety concern.

  11. Scientific Opinion on the re-evaluation of Indigo Carmine (E 132 as a food additive

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Food Additives and Nutrient Sources added to food (ANS

    2014-07-01

    Full Text Available The ANS Panel provides a scientific opinion re-evaluating the safety of Indigo Carmine (E132. The Panel observed that Indigo Carmine was poorly absorbed and does not raise concern for genotoxicity. No adverse effects in subacute, chronic, reproduction and developmental toxicity studies, and no modifications of haematological and biological parameters in chronic toxicity studies have been identified at doses less than or equal to 500 mg/kg bw/day. The only report of an adverse effect was in testis with a LOAEL of 17 mg/kg bw/day which would give rise to a safety concern if confirmed. The Panel considered that this study has shortcomings since it is not clear to the Panel whether the adverse effects observed were due to the food additive itself or to impurities and/or contaminants present in the material tested and/or to the conduct of the study. The Panel considered that the current ADI of 5 mg/kg bw/day for Indigo Carmine was applicable to a material with the same purity and manufacturing process as material used in studies without adverse effects on testis (93% pure colouring and 7% volatile matter and concluded that any extension of this ADI to Indigo Carmine of lower purity and/or manufactured using a different process would require new data which would need to address the adverse effects on testis. The Panel noted that at the MPL, exposure estimates of Indigo Carmine would exceed the ADI for toddlers and children at the high level. Exposure estimates using the available usage and analytical data did not show an exceedance of the ADI for any population groups.

  12. Fear but not fright: re-evaluating traumatic experience attenuates anxiety-like behaviors after fear conditioning

    Directory of Open Access Journals (Sweden)

    Marco eCostanzi

    2014-08-01

    Full Text Available Fear allows organisms to cope with dangerous situations and remembering these situations has an adaptive role preserving individuals from injury and death. However, recalling traumatic memories can induce re-experiencing the trauma, thus resulting in a maladaptive fear. A failure to properly regulate fear responses has been associated with anxiety disorders, like Posttraumatic Stress Disorder (PTSD. Thus, re-establishing the capability to regulate fear has an important role for its adaptive and clinical relevance. Strategies aimed at erasing fear memories have been proposed, although there are limits about their efficiency in treating anxiety disorders. To re-establish fear regulation, here we propose a new approach, based on the re-evaluation of the aversive value of traumatic experience. Mice were submitted to a contextual-fear-conditioning paradigm in which a neutral context was paired with an intense electric footshock. Three weeks after acquisition, conditioned mice were treated with a less intense footshock (pain threshold. The effectiveness of this procedure in reducing fear expression was assessed in terms of behavioral outcomes related to PTSD (e.g. hyper-reactivity to a neutral tone, anxiety levels in a plus maze task, social avoidance, and learning deficits in a spatial water maze and of amygdala activity by evaluating c-fos expression. Furthermore, a possible role of lateral orbitofrontal cortex (lOFC in mediating the behavioral effects induced by the re-evaluation procedure was investigated. We observed that this treatment (i significantly mitigates the abnormal behavioral outcomes induced by trauma, (ii persistently attenuates fear expression without erasing contextual memory, (iii prevents fear reinstatement, (iv reduces amygdala activity and (v requires an intact lOFC to be effective.The results suggest that an effective strategy to treat pathological anxiety should address cognitive re-evaluation of traumatic experiences

  13. Recruitment processes in Baltic sprat - A re-evaluation of GLOBEC Germany hypotheses

    Science.gov (United States)

    Voss, Rüdiger; Peck, Myron A.; Hinrichsen, Hans-Harald; Clemmesen, Catriona; Baumann, Hannes; Stepputtis, Daniel; Bernreuther, Matthias; Schmidt, Jörn O.; Temming, Axel; Köster, Fritz W.

    2012-12-01

    The GLOBEC Germany program (2002-2007) had the ambitious goal to resolve the processes impacting the recruitment dynamics of Baltic sprat (Sprattus sprattus L.) by examining various factors affecting early life history stages. At the start of the research program, a number of general recruitment hypotheses were formulated, i.e. focusing on (1) predation, (2) food availability, (3) physical parameters, (4) the impact of current systems, and finally (5) the importance of top-down vs bottom-up effects. The present study synthesizes the results of field sampling (2002 and 2003), laboratory experiments, and modeling studies to re-evaluate these hypotheses for the Baltic sprat stock. Recruitment success was quite different in the 2 years investigated. Despite a lower spawning stock biomass in 2003, the total number of recruits was almost 2-fold higher that year compared to 2002. The higher recruitment success in 2003 could be attributed to enhanced survival success during the post-larval/juvenile stage, a life phase that appears to be critical for recruitment dynamics. In the state of the Baltic ecosystem during the period of investigation, we consider bottom-up control (e.g. temperature, prey abundance) to be more important than top-down control (predation mortality). This ranking in importance does not vary seasonally. Prevailing water circulation patterns and the transport dynamics of larval cohorts have a strong influence on sprat recruitment success. Pronounced transport to coastal areas is detrimental for year-class strength particularly at high sprat stock sizes. A suggested mechanism is density-dependant regulation of survival via intra- and inter-specific competition for prey in coastal areas. A documented change in larval vertical migration behavior between the early 1990s and early 2000s increased the transport potential to the coast, strengthening the coupling between inter-annual differences in the magnitude and direction of wind-driven surface currents and

  14. Reevaluation of fuel enthalpy in NSRR test for high burnup fuels

    International Nuclear Information System (INIS)

    adopted in the present reevaluation is described and the result is discussed; how the correction made can affect the PCMI failure limit and interpretation of other fuel behaviors, derived from the NSRR test results, such as cladding temperature, cladding deformation, and fission gas release under RIA conditions. (author)

  15. REEVALUATION OF MALARIA PARASITES IN EL-FAYOUM GOVERNORATE, EGYPT USING RAPID DIAGNOSTIC TESTS (RDTS).

    Science.gov (United States)

    Dahesh, Salwa M A; Mostafa, Heba I

    2015-12-01

    Malaria as a disease has been identified in Egypt since ancient times. Malaria was endemic in almost all parts of the country but prevalence showed a steady decrease by 1990, and regressed in most of the Governorates. Then by the end of 1998 till now Egypt become free from local transmission of malaria. All reported cases were imported mainly from Sudan. However, the outbreak of falciparum (1 case) and vivax (23 cases) that occurred (May 2014) in Aswan Governorate strongly indicated that malaria is reemerging in the country. El-Fayoum should be take special attention, rather than being the last residual focus. The efficient malaria vector A. sergenti, the proven vector A. pharoensis and the suspected vector A. multicolor were encountered. This work reevaluated malaria status by using RDTs in survey and Giemsa stained thick films to confirm positive cases and estimation of parasite rate, formula, densities and species, also to study the ecological and entomological efficacy factors. The result showed that out of 2044 examined persons, 14 (0.68%) were passive cases, i.e., attending themselves to El-Fayoum Malaria Units after their return from Sudan. Microscopic examination of their stained thick films obtained from MOH&P shows that 9 (64.2%) out of passive cases were positive 3 of them are P. falciparum (33.3%) and the rest P. vivax 6 (66.7%) The species formulas of P. falciparum and P. vivax were 33.3% and 66.7% respectively. Concerning the density class, only one vivax case was of low density class while the other cases were of high density class. All positive cases were males, imported from Sudan and most of them were merchants having trade activities in Sudan. All examined persons during active case detection ACD (1551) and neighborhood of detected cases NOD (479) were malaria negative by rapid diagnostic tests. The areas recording the highest number of imported cases were Abu Shanap, Aboxa (Ballona) and Kafr Aboud (Abshaway Center) but no Anopheline spp larvae

  16. A swipe at the dragon of the commonplace : a re-evaluation of George MacDonald's fiction

    OpenAIRE

    Stelle, Ginger

    2011-01-01

    This thesis offers a re-evaluation of the fiction of George MacDonald (1824-1905), both fantasy and non-fantasy. The general trend in MacDonald studies is to focus primarily on his works of fantasy, either ignoring the rest (which includes non-fantasy fiction, sermons, poetry, and criticism) or using them to illuminate the fantasies. The overall critical consensus is that these works, particularly MacDonald’s non-fantasy fiction, possess little inherent value. Though many critics acknowled...

  17. Safety Re-evaluation of Kyoto University Research Reactor by reflecting the Accident of Fukushima Daiichi Nuclear Power Plant

    Energy Technology Data Exchange (ETDEWEB)

    Nakajima, K.; Yamamoto, T. [Kyoto Univ., Kyoto (Japan)

    2013-07-01

    Kyoto University Research Reactor (KUR) is a light-water moderated tank-type reactor operated at rated thermal power of 5MW. After the accident of Fukushima Daiichi nuclear power plant, we have settled a 40-ton water tank near the reactor room, and prepared a mobile fire pump and a mobile power generator as additional safety measures for beyond design basis accidents (BDBAs). We also have conducted the safety re-evaluation of KUR, and confirmed that the integrity of KUR fuels could be kept against the BDBA with the use of the additional safety measures when the several restrictions were imposed on the reactor operation.

  18. Scientific Opinion on the re-evaluation of Patent Blue V (E 131) as a food additive

    OpenAIRE

    EFSA Panel on Food Additives and Nutrient Sources added to food (ANS)

    2013-01-01

    The Panel on Food Additives and Nutrient Sources added to Food provides a scientific opinion re-evaluating the safety of Patent Blue V (E 131). Patent Blue V (E 131) is a triarylmethane dye permitted for use as a food additive in the EU, that has been previously evaluated by JECFA in 1970 and 1975 and the EU SCF in 1983; JECFA established a Temporary Acceptable Daily Intake (ADI) of 0-1 mg/kg bw/day in 1970, but withdrew it in 1975. Until now JECFA has not allocated an ADI to Patent Blue V (E...

  19. Reevaluating Bounds on Flavor-Changing Neutral Current Parameters in R-parity Conserving and R-parity Violating Supersymmetry

    CERN Document Server

    Saha, J P; Saha, Jyoti Prasad; Kundu, Anirban

    2004-01-01

    We perform a systematic reevaluation of the constraints on the flavor-changing neutral current (FCNC) parameters in R-parity conserving and R-parity violating supersymmetric models. As a typical process, we study the constraints coming from the measurements on the B0-\\bar{B0} system on the supersymmetric $\\delta^d_{13}$ parameters, as well as on the products of the lambda' type R-parity violating couplings. Present data allows us to put constraints on both the real and the imaginary parts of the relevant parameters.

  20. Covalently bound phosphate residues in bovine milk xanthine oxidase and in glucose oxidase from Aspergillus niger: A reevaluation

    International Nuclear Information System (INIS)

    The reported presence of covalently bound phosphate residues in flavoproteins has significant implications with regard to the catalytic mechanisms and structural stability of the specific enzymes themselves and in terms of general cellular metabolic regulation. These considerations have led to a reevaluation of the presence of covalently bound phosphorus in the flavoproteins xanthine oxidase and glucose oxidase. Milk xanthine oxidase purified by a procedure that includes anion-exchange chromatography is shown to contain three phosphate residues. All three are noncovalently associated with the protein, two with the FAD cofactor, and one with the molybdenum cofactor. Results of chemical analysis and 31P NMR spectroscopy indicate that enzyme purified by this method contains no phosphoserine residues. Xanthine oxidase preparations purified by chromatography on calcium phosphate gel in place of DEAE-Sephadex yielded higher phosphate-to-protein ratios, which could be reduced to the expected values by additional purification on a folate affinity column. Highly active, highly purified preparations of glucose oxidase are shown to contain only the two phosphate residues of the FAD cofactor. The covalently bound bridging phosphate reported by others may arise in aged or degraded preparations of the enzyme but appears not to be a constituent of functional glucose oxidase. These results suggest that the presence of covalent phosphate residues in other flavoproteins should be rigorously reevaluated as well

  1. Ozone balloon soundings at Payerne (Switzerland): Reevaluation of the time series 1967-2002 and trend analysis

    Science.gov (United States)

    Jeannet, P.; Stübi, R.; Levrat, G.; Viatte, P.; Staehelin, J.

    2007-06-01

    This study documents the history of the Payerne (Switzerland) ozone series obtained with the Brewer-Mast sonde from the end of 1966 until the change to the electrochemical concentration cell (ECC) sonde in autumn 2002, as well as the reevaluation of the original data. Several corrections were made in order to improve the homogeneity and the quality of the time series. We furthermore derived long-term trends for the reevaluated time series using atmospheric variables in a stepwise regression model. In the stratosphere, trends over the 1970-2002 period remain nearly the same as over periods ending a few years earlier. For tropospheric ozone trends, a hockey stick model allowing for a change in trend in 1990 was used and a sensitivity analysis with different data sets was carried out. Besides the standard World Meteorological Organization (WMO) data evaluation procedure, we used alternative data sets (1) accounting for the preflight laboratory calibrations, or (2) ignoring the total ozone normalization, (3) as well as correcting for chemical interference with SO2. With all data sets, tropospheric trends were strongly positive in all seasons over the 1967-1989 period. In the 1990-2002 period, winter trends remained positive over the whole troposphere with all data sets, whereas in the other seasons, trends were generally negative near the ground and shifted to zero or positive values with increasing altitude in the troposphere. The alternative evaluation procedures strongly affect the derived tropospheric trends in the 1990-2002 period and their uncertainties.

  2. Is the Gop rift oceanic? A reevaluation of the Seychelles-India conjugate margins

    Science.gov (United States)

    Guan, Huixin; Werner, Philippe; Geoffroy, Laurent

    2016-04-01

    Recent studies reevaluated the timing and evolution of the breakup process between the Seychelles continental ridge and India, and the relationship between this evolution and mantle melting associated with the Deccan Igneous Province1,2,3. Those studies, mainly based on gravity and seismic refraction surveys, point that the oceanic domain located between the Seychelles and the Laxmi Ridge (here designed as the Carlsberg Basin) is the youngest oceanic domain between India and the Seychelles. To the East of the Laxmi Ridge, the aborted Gop Rift is considered as an older highly magmatic extensional continental system with magmatism, breakup and oceanic spreading being coeval with or even predating the emplacement of the major pulse of the Deccan trapps. This interpretation on the oceanic nature of the Gop Rift conflicts with other extensive surveys based on magnetic and seismic reflection data4 which suggest that the Gop Rift is an extended syn-magmatic continental domain. In our work based (a) on the existing data, (b) on new deep-seismic reflection surveys (already published by Misra5) down to the Moho and underlying mantle and (c) on new concepts on the geometry of volcanic passive margins, we propose a distinct interpretation of the Seychelles-India system. As proposed by former authors6,7, the Indian margin suffered some continental stretching and thinning before the onset of the Deccan traps during the Mesozoic. Thus continental crust thickness cannot be used easily as a proxy of syn-magmatic stretching-thinning processes or even to infer the presence or not of oceanic-type crust based, solely, on crustal thickness. However, some remarkable features appear on some of the deep penetration seismic lines we studied. We illustrate that the whole Seychelles/India system, before the opening of the present-day "Carlsberg Basin" may simply be regarded as a pair of sub-symmetric conjugate volcanic passive margins (VPMs) with inner and outer SDR wedges dipping towards the

  3. Re-Evaluation of the 1921 Peak Discharge at Skagit River near Concrete, Washington

    Science.gov (United States)

    Mastin, M.C.

    2007-01-01

    The peak discharge record at the U.S. Geological Survey (USGS) gaging station at Skagit River near Concrete, Washington, is a key record that has come under intense scrutiny by the scientific and lay person communities in the last 4 years. A peak discharge of 240,000 cubic feet per second for the flood on December 13, 1921, was determined in 1923 by USGS hydrologist James Stewart by means of a slope-area measurement. USGS then determined the peak discharges of three other large floods on the Skagit River (1897, 1909, and 1917) by extending the stage-discharge rating through the 1921 flood measurement. The 1921 estimate of peak discharge was recalculated by Flynn and Benson of the USGS after a channel roughness verification was completed based on the 1949 flood on the Skagit River. The 1949 recalculation indicated that the peak discharge probably was 6.2 percent lower than Stewart's original estimate but the USGS did not officially change the peak discharge from Stewart's estimate because it was not more than a 10-percent change (which is the USGS guideline for revising peak flows) and the estimate already had error bands of 15 percent. All these flood peaks are now being used by the U.S. Army Corps of Engineers to determine the 100-year flood discharge for the Skagit River Flood Study so any method to confirm or improve the 1921 peak discharge estimate is warranted. During the last 4 years, two floods have occurred on the Skagit River (2003, 2006) that has enabled the USGS to collect additional data, do further analysis, and yet again re-evaluate the 1921 peak discharge estimate. Since 1949, an island/bar in the study reach has reforested itself. This has complicated the flow hydraulics and made the most recent recalculation of the 1921 flood based on channel roughness verification that used 2003 and 2006 flood data less reliable. However, this recent recalculation did indicate that the original peak-discharge calculation by Stewart may be high, and it added to a

  4. Statement on a conceptual framework for the risk assessment of certain food additives re-evaluated under Commission Regulation (EU) No 257/2010

    OpenAIRE

    EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)

    2014-01-01

    The Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific statement presenting a conceptual framework for the risk assessment of certain food additives re-evaluated under Commission Regulation (EU) No 257/2010. This framework will be used in the evaluation made by the Panel, but the expert judgement of the scientific background, on a case-by-case basis, remains essential to reach a final conclusion. The outcome of the re-evaluation of food additives taking int...

  5. New tool for biological dosimetry: Reevaluation and automation of the gold standard method following telomere and centromere staining

    Energy Technology Data Exchange (ETDEWEB)

    M’kacher, Radhia [Laboratoire de Radiobiologie et Oncologie (LRO), Commissariat à l’Energie Atomique (CEA), Route du Panorama, 92265 Fontenay-aux-Roses (France); Maalouf, Elie E.L. [Laboratoire de Radiobiologie et Oncologie (LRO), Commissariat à l’Energie Atomique (CEA), Route du Panorama, 92265 Fontenay-aux-Roses (France); Laboratoire MIPS – Groupe TIIM3D, Université de Haute-Alsace, F-68093 Mulhouse (France); Ricoul, Michelle [Laboratoire de Radiobiologie et Oncologie (LRO), Commissariat à l’Energie Atomique (CEA), Route du Panorama, 92265 Fontenay-aux-Roses (France); Heidingsfelder, Leonhard [MetaSystems GmbH, Robert-Bosch-Str. 6, 68804 Altlussheim (Germany); Laplagne, Eric [Pole Concept, 61 Rue Erlanger, 75016 Paris (France); Cuceu, Corina; Hempel, William M. [Laboratoire de Radiobiologie et Oncologie (LRO), Commissariat à l’Energie Atomique (CEA), Route du Panorama, 92265 Fontenay-aux-Roses (France); Colicchio, Bruno; Dieterlen, Alain [Laboratoire MIPS – Groupe TIIM3D, Université de Haute-Alsace, F-68093 Mulhouse (France); Sabatier, Laure, E-mail: laure.sabatier@cea.fr [Laboratoire de Radiobiologie et Oncologie (LRO), Commissariat à l’Energie Atomique (CEA), Route du Panorama, 92265 Fontenay-aux-Roses (France)

    2014-12-15

    Graphical abstract: - Highlights: • We have applied telomere and centromere (TC) staining to the scoring of dicentrics. • TC staining renders the scoring of dicentrics more rapid and robust. • TC staining allows the scoring of not only dicentrics but all chromosomal anomalies. • TC staining has led to a reevaluation of the radiation dose–response curve. • TC staining allows automation of the scoring of chromosomal aberations. • Automated scoring of dicentrics after TC staining was as efficient as manual scoring. - Abstract: Purpose: The dicentric chromosome (dicentric) assay is the international gold-standard method for biological dosimetry and classification of genotoxic agents. The introduction of telomere and centromere (TC) staining offers the potential to render dicentric scoring more efficient and robust. In this study, we improved the detection of dicentrics and all unstable chromosomal aberrations (CA) leading to a significant reevaluation of the dose–effect curve and developed an automated approach following TC staining. Material and methods: Blood samples from 16 healthy donors were exposed to {sup 137}Cs at 8 doses from 0.1 to 6 Gy. CA were manually and automatically scored following uniform (Giemsa) or TC staining. The detection of centromeric regions and telomeric sequences using PNA probes allowed the detection of all unstable CA: dicentrics, centric and acentric rings, and all acentric fragments (with 2, 4 or no telomeres) leading to the precise quantification of estimated double strand breaks (DSB). Results: Manual scoring following TC staining revealed a significantly higher frequency of dicentrics (p < 10{sup −3}) (up to 30%) and estimated DSB (p < 10{sup −4}) compared to uniform staining due to improved detection of dicentrics with centromeres juxtaposed with other centromeres or telomeres. This improvement permitted the development of the software, TCScore, that detected 95% of manually scored dicentrics compared to 50% for

  6. Uncertainty reevaluation in determining the volume of a silicon sphere by spherical harmonics in an Avogadro project

    Institute of Scientific and Technical Information of China (English)

    Zhang Ji-Tao; Wu Xue-Jian; Li Yan

    2011-01-01

    To determine the Avogadro constant with a target relative uncertainty of 2×10-8,the uncertainty component of the silicon sphere's volume introduced by the spherical harmonics method,which is usually used in determining the sphere's volume,is reevaluated. By means of representing the shape of the silicon sphere by an ellipsoid with Gaussian white noise in its diameters,the uncertainty of the current mapping methods based on the spherical harmonics theory can be estimated theoretically. It is evidenced that the uncertainty component attributed to the current mapping method is underestimated. To eliminate this effect as much as possible,the number of mapping points should be increased to more than before. Moreover,a new mapping method is proposed to accomplish the equal-area mapping with large number points on the silicon sphere.

  7. Re-evaluation of the age of the Brandon Lignite (Vermont, USA) based on plant megafossils. [USA - Vermont

    Energy Technology Data Exchange (ETDEWEB)

    Tiffney, B.H. (University of California at Santa Barbara, Santa Barbara, CA (United States). Dept. of Geological Sciences)

    1994-07-01

    The Brandon Lignite of west-central Vermont contains the northernmost megafossil flora of Cenozoic angiosperms, and one of the most diverse Cenozoic pollen floras in northeastern North America. While the floristic composition clearly indicates deposition of the Brandon sediments in the warmer parts of the Cenozoic, previous attempts at a more precise stratigraphic placement have been inconclusive, ranging from Cretaceous to Miocene. Re-evaluation of existing and new fruit, seed and wood data from the Brandon flora in the context of other floras in the Northern Hemisphere leads to the conservative conclusion that the deposit could range from earliest Oligocene to Early Miocene. Several lines of potentially weak evidence favor an Early Miocene age, in agreement with recent biostratigraphic data from the associated pollen flora. It is concluded that the Brandon Lignite is Early Miocene.

  8. Re-evaluation of the neutron scattering dynamics in heavy water, generation of multigroup cross sections for THERM-126

    International Nuclear Information System (INIS)

    In providing THERM-126 with cross section matrices for deuterium bound in heavy water the IKE phonon spectrum was reevaluated. The changes are modifications in the acoustic part and in the frequency of the second oscillator. Contrary to the phonon spectrum model for D in D2O in ENDF/B-IV the broad band of hindered rotations is assumed to be temperature dependent taking into account the diffusive motion of the molecule. With the new model scattering law data S (α, β) are generated in the temperature range 293.6 K-673.6 K. The THERM-126 scattering cross section matrices are calculated up to P3. As a validity check a lot of differential and integral cross sections are compared to experiments and benchmarks are recalculated. (orig.)

  9. Effects of major depression, aging and gender upon calculated diurnal free plasma cortisol concentrations: a re-evaluation study.

    Science.gov (United States)

    Deuschle, M; Weber, B; Colla, M; Depner, M; Heuser, I

    1998-12-01

    Depression, aging and female gender are associated with increased diurnal concentrations of total plasma cortisol. For the physical effects of hypercortisolemia, however, it is generally assumed that free rather than total plasma cortisol concentrations are of importance. Herein, we report a mathematical approach to determine free plasma cortisol concentrations on the basis of total cortisol, corticosteroid binding-globulin (CBG) and albumin plasma concentrations. This approach was used to re-evaluate two sets of data in order to estimate the effect of depression as well as the effect of aging and gender upon free plasma cortisol concentrations. Comparing male depressed patients with healthy controls, we found 24-hour free cortisol minima (MIN: 4.1 +/- 1.8 vs. 1.6 +/- 1.1 nmol/l, p MAX: 85.3 +/- 23.3 vs. 45.2 +/- 15. 8 nmol/l, p problems triggered and/or maintained by glucocorticoids (e.g. osteoporosis) are frequently seen.

  10. Regulations and guidelines should be strengthened urgently for re-evaluation on post-marketing medicines in China.

    Science.gov (United States)

    Xie, Yan-Ming; Tian, Feng

    2013-07-01

    This paper reviewed the situation of regulations and guidelines on post-marketing medicines in the developed countries and in China. The developed countries have accumulated a lot of empirical principles and techniques on postmarketing surveillance (also named pharmacovigilance), therefore, their regulation systems are nearly perfect. In China, the regulations on post-marketing re-evaluation and relative technical guidelines do not cover the whole aspects, even lack in some important aspects, and long-term risk management mechanisms have not been established. So it is urgent to establish new regulations and improve the regulatory system in China based on the existing regulations and guidelines, by learning from the ideas of foreign advanced regulations, then fully integrating them with China's actual conditions, and cooperating with multidisciplinary researchers. PMID:23818198

  11. Re-evaluation of the histopathologic classification of ANCA-associated glomerulonephritis : a study of 121 patients in a single center

    NARCIS (Netherlands)

    Chang, Dong-yuan; Wu, Li-hua; Liu, Gang; Chen, Min; Kallenberg, Cees G. M.; Zhao, Ming-Hui

    2012-01-01

    Background. The recently published histopathologic classification of antineutrophil cytoplasmic antibody (ANCA)associated glomerulonephritis might greatly aid in the prognostication of patients at the time of diagnosis. This study aims to re-evaluate the new classification for its prognostic capacit

  12. Statistical re-evaluation of the ASME K{sub IC} and K{sub IR} fracture toughness reference curves

    Energy Technology Data Exchange (ETDEWEB)

    Wallin, K.; Rintamaa, R. [Valtion Teknillinen Tutkimuskeskus, Espoo (Finland)

    1998-11-01

    Historically the ASME reference curves have been treated as representing absolute deterministic lower bound curves of fracture toughness. In reality, this is not the case. They represent only deterministic lower bound curves to a specific set of data, which represent a certain probability range. A recently developed statistical lower bound estimation method called the `Master curve`, has been proposed as a candidate for a new lower bound reference curve concept. From a regulatory point of view, the Master curve is somewhat problematic in that it does not claim to be an absolute deterministic lower bound, but corresponds to a specific theoretical failure probability that can be chosen freely based on application. In order to be able to substitute the old ASME reference curves with lower bound curves based on the master curve concept, the inherent statistical nature (and confidence level) of the ASME reference curves must be revealed. In order to estimate the true inherent level of safety, represented by the reference curves, the original data base was re-evaluated with statistical methods and compared to an analysis based on the master curve concept. The analysis reveals that the 5% lower bound Master curve has the same inherent degree of safety as originally intended for the K{sub IC}-reference curve. Similarly, the 1% lower bound Master curve corresponds to the K{sub IR}-reference curve. (orig.)

  13. Re-evaluation of thermal shock experiment results based on the VTT approach for statistical treatment of fracture toughness data

    International Nuclear Information System (INIS)

    One important step in fracture mechanical research has been thermal shock experiments (TSE). The TSEs are exceptional because many of them had extremely long crack fronts. As a trend, the TSE initiation fracture toughness results form a lower bound to the small specimen data used for material characterization. Presently, work is under way to produce an ASTM testing standard for fracture toughness testing in the transition region. The standard is based on the VTT approach for statistical treatment of fracture toughness data. Key components in the VTT approach are statistical expressions for describing the data scatter and for predicting a specimens size effect, and an expression for the fracture toughness temperature dependence. In order to examine the validity of the statistical size effect assumption, the TSEs were reevaluated with the VTT approach. For all the TSEs investigated, the application of the statistical size correction has had the effect of bringing the material characterization data in agreement with the actual TSE results. Furthermore, the application of a statistically defined size-corrected lower bound toughness estimate, based on the small specimen material characterization data and the master curve, yield a conservative, but realistic, estimate of the TSE failure behaviour. (orig.)

  14. Re-evaluation of the criticality experiments of the ''Otto Hahn Nuclear Ship'' reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lengar, I.; Snoj, L.; Rogan, P.; Ravnik, M. [Jozef Stefan Institute, Ljubljana (Slovenia)

    2008-11-15

    Several series of experiments with a FDR reactor (advanced pressurized light water reactor) were performed in 1972 in the Geesthacht critical facility ANEX. The experiments were performed to test the core prior to its usage for the propulsion of the first German nuclear merchant ship ''Otto-Hahn''. In the present paper a calculational re-evaluation of the experiments is described with the use of the up-to date computer codes (Monte-Carlo code MCNP5) and nuclear data (ENDF/B-VI release 6). It is focused on the determination of uncertainties in the benchmark model of the experimental set-up, originating mainly from the limited set of information still available about the experiments. Effects of the identified uncertainties on the multiplication factor were studied. The sensitivity studies include parametric variation of material composition and geometry. The combined total uncertainty being found 0.0050 in k{sub eff}, the experiments are qualified as criticality safety benchmark experiments. (orig.)

  15. Re-evaluation of Predictive Models in Light of New Data: Sunspot Number Version 2.0

    Science.gov (United States)

    Gkana, A.; Zachilas, L.

    2016-10-01

    The original version of the Zürich sunspot number (Sunspot Number Version 1.0) has been revised by an entirely new series (Sunspot Number Version 2.0). We re-evaluate the performance of our previously proposed models for predicting solar activity in the light of the revised data. We perform new monthly and yearly predictions using the Sunspot Number Version 2.0 as input data and compare them with our original predictions (using the Sunspot Number Version 1.0 series as input data). We show that our previously proposed models are still able to produce quite accurate solar-activity predictions despite the full revision of the Zürich Sunspot Number, indicating that there is no significant degradation in their performance. Extending our new monthly predictions (July 2013 - August 2015) by 50 time-steps (months) ahead in time (from September 2015 to October 2019), we provide evidence that we are heading into a period of dramatically low solar activity. Finally, our new future long-term predictions endorse our previous claim that a prolonged solar activity minimum is expected to occur, lasting up to the year ≈ 2100.

  16. Temporomandibular disorder subtypes according to self-reported physical and psychosocial variables in female patients: a re-evaluation.

    Science.gov (United States)

    Suvinen, T I; Reade, P C; Hanes, K R; Könönen, M; Kemppainen, P

    2005-03-01

    Several studies support the relevance of psychological and psychosocial factors in the assessment and management of chronic musculoskeletal pain disorders, including temporomandibular pain disorders (TMDs). The aim of this study was to re-evaluate subtyping approach used in an earlier study (TI Suvinen, KR Hanes, JA Gerschman, PC Reade. J Orofac Pain 1997;11:200) and to compare perceived physical symptoms, psychological, coping and psychosocial variables between subtypes of patients who seek treatment for their temporomandibular pain and dysfunction. A total of 41 consecutive female patients were assessed multiaxially for physical symptoms, coping style and effectiveness and illness behaviour by a previously validated Temporomandibular Pain Dysfunction Questionnaire (TI Suvinen, KR Hanes, JA Gerschman, PC Reade. J Orofac Pain 1997;11:200). Additional measures of psychosocial variables included the global scores of the Beck Depression and Anxiety Inventory and Part I of the Multidimensional Pain Inventory. Subtypes were generated using an iterative partitioning method, k-means cluster analysis. Three clusters were identified and termed as Simple (22%), Intermediate (41%) and Complex (37%) temporomandibular disorders subtypes. Significant differences (P temporomandibular pain patients to guide management, based on the constellation of predominant psychological and psychosocial illness impact variables. PMID:15707426

  17. LipL32 Is a Subsurface Lipoprotein of Leptospira interrogans: presentation of new data and reevaluation of previous studies.

    Directory of Open Access Journals (Sweden)

    Marija Pinne

    Full Text Available The agents of leptospirosis, a zoonosis with worldwide distribution, are pathogenic spirochetes belonging to the genus Leptospira. The leptospiral life cycle involves transmission via fresh water and colonization of the renal tubules of their reservoir hosts. Infection of accidental hosts, including humans, may result in life-threatening sequelae. Bacterial outer membrane proteins (OMPs, particularly those with surface-exposed regions, play crucial roles in pathogen virulence mechanisms and adaptation to environmental conditions, including those found in the mammalian host. Therefore, elucidation and characterization of the surface-exposed OMPs of Leptospira spp. is of great interest in the leptospirosis field. A thorough, multi-pronged approach for assessing surface exposure of leptospiral OMPs is essential. Herein, we present evidence for a sub-surface location for most or all of the major leptospiral lipoprotein, LipL32, based on surface immunofluorescence utilizing three different types of antibodies and four different permeabilization methods, as well as surface proteolysis of intact and lysed leptospires. We reevaluate prior evidence presented in support of LipL32 surface-exposure and present a novel perspective on a protein whose location has been misleading researchers, due in large part to its extraordinary abundance in leptospiral cells.

  18. Fever of unknown origin; Re-evaluation of sup 67 Ga scintigraphy in detecting causes of fever

    Energy Technology Data Exchange (ETDEWEB)

    Misaki, Takashi; Matsui, Akira; Tanaka, Fumiko; Okuno, Yoshishige; Mitsumori, Michihide; Torizuka, Tatsurou; Dokoh, Shigeharu; Hayakawa, Katsumi; Shimbo, Shin-ichirou (Kyoto City Hospital (Japan))

    1990-06-01

    Gallium-67 scintigraphy is a commonly performed imaging modality in deteting pyrogenic lesions in cases of long-standing inexplainable fever. To re-evaluate the significance of gallium imaging in such cases, a retrospective review was made of 56 scans performed in febrile patients in whom sufficient clinical and laboratory findings were obtained. Gallium scans were true positive in 30 patients, false positive in 3, true negative in 19, and false negative in 4. In the group of true positive, local inflammatory lesions were detected in 23 patients with a final diagnosis of lung tuberculosis, urinary tract infection, and inflammatory joint disease. Abnormal gallium accumulation, as shown in the other 7 patients, provided clues to the diagnosis of generalized disorders, such as hematological malignancies (n=3), systemic autoimmune diseases (n=3), and severe infectious mononucleosis (n=one). In the group of false positive, gallium imaging revealed intestinal excretion of gallium in 2 patients and physiological pulmonary hilar accumulation in one. In the true negative group of 19 patients, fever of unknown origin was resolved spontaneously in 12 patients, and with antibiotics and corticosteroids in 2 and 5 patients, respectively. Four patients having false negative scans were finally diagnosed as having urinary tract infection (n=2), bacterial meningitis (n=one), and polyarteritis (n=one). Gallium imaging would remain the technique of choice in searching for origin of unknown fever. It may also be useful for early diagnosis of systemic disease, as well as focal inflammation. (N.K.).

  19. Bad taxonomy can kill : molecular reevaluation of Unio mancus Lamarck, 1819 (Bivalvia : Unionidae and its accepted subspecies

    Directory of Open Access Journals (Sweden)

    Prie V.

    2012-07-01

    Full Text Available The conservation status of European unionid species rests on the scientific knowledge of the 1980s, before the current revival of taxonomic reappraisals based on molecular characters. The taxonomic status of Unio mancus Lamarck, 1819, superficially similar to Unio pictorum (Linnaeus, 1758 and often synonymized with it, is re-evaluated based on a random sample of major French drainages and a systematic sample of historical type localities. We confirm the validity of U. mancus as a distinct species occurring in France and Spain, where it is structured into three geographical units here ranked as subspecies: U. m. mancus [Atlantic drainages, eastern Pyrenees, Spanish Mediterranean drainages], U. m. turtonii Payraudeau, 1826 [coastal drainages East of the Rhône and Corsica] and U. m. requienii Michaud, 1831 [Seine, Saône-Rhône, and coastal drainages West of the Rhône]. Many populations of Unio mancus have been extirpated during the 20th century and the remaining populations continue to be under pressure; U. mancus satisfies the criteria to be listed as «Endangered» in the IUCN Red List.

  20. Flagellar movement in two bacteria of the family rickettsiaceae: a re-evaluation of motility in an evolutionary perspective.

    Directory of Open Access Journals (Sweden)

    Claudia Vannini

    Full Text Available Bacteria of the family Rickettsiaceae have always been largely studied not only for their importance in the medical field, but also as model systems in evolutionary biology. In fact, they share a recent common ancestor with mitochondria. The most studied species, belonging to genera Rickettsia and Orientia, are hosted by terrestrial arthropods and include many human pathogens. Nevertheless, recent findings show that a large part of Rickettsiaceae biodiversity actually resides outside the group of well-known pathogenic bacteria. Collecting data on these recently described non-conventional members of the family is crucial in order to gain information on ancestral features of the whole group. Although bacteria of the family Rickettsiaceae, and of the whole order Rickettsiales, are formally described as non-flagellated prokaryotes, some recent findings renewed the debate about this feature. In this paper we report the first finding of members of the family displaying numerous flagella and active movement inside their host cells. These two new taxa are hosted in aquatic environments by protist ciliates and are described here by means of ultrastructural and molecular characterization. Data here reported suggest that the ancestor of Rickettsiales displayed flagellar movement and re-evaluate the hypothesis that motility played a key-role in the origin of mitochondria. Moreover, our study highlights that the aquatic environment represents a well exploited habitat for bacteria of the family Rickettsiaceae. Our results encourage a deep re-consideration of ecological and morphological traits of the family and of the whole order.

  1. Reevaluation of fatty acid receptor 1 as a drug target for the stimulation of insulin secretion in humans.

    Science.gov (United States)

    Wagner, Robert; Kaiser, Gabriele; Gerst, Felicia; Christiansen, Elisabeth; Due-Hansen, Maria E; Grundmann, Manuel; Machicao, Fausto; Peter, Andreas; Kostenis, Evi; Ulven, Trond; Fritsche, Andreas; Häring, Hans-Ulrich; Ullrich, Susanne

    2013-06-01

    The role of free fatty acid receptor 1 (FFAR1/GPR40) in glucose homeostasis is still incompletely understood. Small receptor agonists stimulating insulin secretion are undergoing investigation for the treatment of type 2 diabetes. Surprisingly, genome-wide association studies did not discover diabetes risk variants in FFAR1. We reevaluated the role of FFAR1 in insulin secretion using a specific agonist, FFAR1-knockout mice and human islets. Nondiabetic individuals were metabolically phenotyped and genotyped. In vitro experiments indicated that palmitate and a specific FFAR1 agonist, TUG-469, stimulate glucose-induced insulin secretion through FFAR1. The proapoptotic effect of chronic exposure of β-cells to palmitate was independent of FFAR1. TUG-469 was protective, whereas inhibition of FFAR1 promoted apoptosis. In accordance with the proapoptotic effect of palmitate, in vivo cross-sectional observations demonstrated a negative association between fasting free fatty acids (NEFAs) and insulin secretion. Because NEFAs stimulate secretion through FFAR1, we examined the interaction of genetic variation in FFAR1 with NEFA and insulin secretion. The inverse association of NEFA and secretion was modulated by rs1573611 and became steeper for carriers of the minor allele. In conclusion, FFAR1 agonists support β-cell function, but variation in FFAR1 influences NEFA effects on insulin secretion and therefore could affect therapeutic efficacy of FFAR1 agonists. PMID:23378609

  2. Scientific Opinion on the re-evaluation of montan acid esters (E 912 as a food additive

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS

    2013-06-01

    Full Text Available Following a request from the European Commission, the EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS was asked to deliver a scientific opinion re-evaluating the safety of montan acid esters (E 912 when used as a food additive. Montan acids are extracted from oxidised montan wax and esterified with ethylene glycol, 1,3-butanediol or triols, to form montan acid esters. Montan acid esters are authorised only for the surface treatment of fresh fruits. No data, specifically for montan acid esters, on toxicokinetics and reproductive and developmental toxicity were available. The available data on short-term and subchronic toxicity, genotoxicity and chronic toxicity and carcinogenicity were limited. Important deficiencies in the available studies on chronic toxicity and carcinogenicity were noticed. The data requested in the 1990s (i.e. chromosomal aberration in vitro, reproduction and teratogenicity studies, material characteristics, impurities, presence of PAHs were not submitted. Furthermore no data were submitted following an EFSA public call for data in 2012. The Panel identified some summary data in the European Chemicals Agency database (ECHA on registered substances that might have been relevant for the assessment of montan acid esters but the original study reports were not made available to EFSA. Based on these limitations in the toxicological database the Panel concluded that montan acid esters as a food additive could not be evaluated.

  3. Flagellar movement in two bacteria of the family rickettsiaceae: a re-evaluation of motility in an evolutionary perspective.

    Science.gov (United States)

    Vannini, Claudia; Boscaro, Vittorio; Ferrantini, Filippo; Benken, Konstantin A; Mironov, Timofei I; Schweikert, Michael; Görtz, Hans-Dieter; Fokin, Sergei I; Sabaneyeva, Elena V; Petroni, Giulio

    2014-01-01

    Bacteria of the family Rickettsiaceae have always been largely studied not only for their importance in the medical field, but also as model systems in evolutionary biology. In fact, they share a recent common ancestor with mitochondria. The most studied species, belonging to genera Rickettsia and Orientia, are hosted by terrestrial arthropods and include many human pathogens. Nevertheless, recent findings show that a large part of Rickettsiaceae biodiversity actually resides outside the group of well-known pathogenic bacteria. Collecting data on these recently described non-conventional members of the family is crucial in order to gain information on ancestral features of the whole group. Although bacteria of the family Rickettsiaceae, and of the whole order Rickettsiales, are formally described as non-flagellated prokaryotes, some recent findings renewed the debate about this feature. In this paper we report the first finding of members of the family displaying numerous flagella and active movement inside their host cells. These two new taxa are hosted in aquatic environments by protist ciliates and are described here by means of ultrastructural and molecular characterization. Data here reported suggest that the ancestor of Rickettsiales displayed flagellar movement and re-evaluate the hypothesis that motility played a key-role in the origin of mitochondria. Moreover, our study highlights that the aquatic environment represents a well exploited habitat for bacteria of the family Rickettsiaceae. Our results encourage a deep re-consideration of ecological and morphological traits of the family and of the whole order.

  4. Development of a standard data base for FBR core nuclear design. 10. Reevaluation of atomic number density of JOYO Mk-II core

    Energy Technology Data Exchange (ETDEWEB)

    Numata, Kazuyuki; Sato, Wakaei [Japan Nuclear Cycle Development Inst., Oarai, Ibaraki (Japan). Oarai Engineering Center; Ishikawa, Makoto; Arii, Yoshio [Nuclear Energy System Incorporation, Tokyo (Japan)

    1999-07-01

    The material composition of JOYO Mk-II core components in its initial core was reevaluated as a part of the effort for developing a standard data base for FBR core nuclear design. The special feature of the reevaluation is to treat the decay of Pu-241 isotope, so that the atomic number densities of Pu-241 and Am-241 in fuel assemblies can be exactly evaluated on the initial critical date, Nov. 22nd, 1982. Further, the atomic number densities of other core components were also evaluated to improve the analytical accuracy. Those include the control rods which were not so strictly evaluated in the past, and the dummy fuels and the neutron sources which were not treated in the analytical model so far. The results of the present reevaluation were as follows: (1) The changes of atomic number densities of the major nuclides such as Pu-239, U-235 and U-238 were about {+-}0.2 to 0.3%. On the other hand, the number density of Pu-241, which was the motivation of the present work, was reduced by 12%. From the fact, the number densities in the past analysis might be based on the isotope measurement of the manufacturing point of time without considering the decay of Pu-241. (2) As the other core components, the number densities of control rods and outer reflector-type A were largely improved. (author)

  5. Re-evaluation of the sorption behaviour of Bromide and Sulfamethazine under field conditions using leaching data and modelling methods

    Science.gov (United States)

    Gassmann, Matthias; Olsson, Oliver; Höper, Heinrich; Hamscher, Gerd; Kümmerer, Klaus

    2016-04-01

    The simulation of reactive transport in the aquatic environment is hampered by the ambiguity of environmental fate process conceptualizations for a specific substance in the literature. Concepts are usually identified by experimental studies and inverse modelling under controlled lab conditions in order to reduce environmental uncertainties such as uncertain boundary conditions and input data. However, since environmental conditions affect substance behaviour, a re-evaluation might be necessary under environmental conditions which might, in turn, be affected by uncertainties. Using a combination of experimental data and simulations of the leaching behaviour of the veterinary antibiotic Sulfamethazine (SMZ; synonym: sulfadimidine) and the hydrological tracer Bromide (Br) in a field lysimeter, we re-evaluated the sorption concepts of both substances under uncertain field conditions. Sampling data of a field lysimeter experiment in which both substances were applied twice a year with manure and sampled at the bottom of two lysimeters during three subsequent years was used for model set-up and evaluation. The total amount of leached SMZ and Br were 22 μg and 129 mg, respectively. A reactive transport model was parameterized to the conditions of the two lysimeters filled with monoliths (depth 2 m, area 1 m²) of a sandy soil showing a low pH value under which Bromide is sorptive. We used different sorption concepts such as constant and organic-carbon dependent sorption coefficients and instantaneous and kinetic sorption equilibrium. Combining the sorption concepts resulted in four scenarios per substance with different equations for sorption equilibrium and sorption kinetics. The GLUE (Generalized Likelihood Uncertainty Estimation) method was applied to each scenario using parameter ranges found in experimental and modelling studies. The parameter spaces for each scenario were sampled using a Latin Hypercube method which was refined around local model efficiency maxima

  6. Reevaluation of the Coding Potential and Proteomic Analysis of the BAC Derived Rhesus Cytomegalovirus Strain 68-1

    Energy Technology Data Exchange (ETDEWEB)

    Malouli, Daniel; Nakayasu, Ernesto S.; Viswanathan, Kasinath; Camp, David G.; Chang, W. L.; Barry, Peter A.; Smith, Richard D.; Fruh, Klaus

    2012-09-01

    Cytomegaloviruses are highly host restricted resulting in co-speciation with their hosts. As a natural pathogen of rhesus macaques (RM), Rhesus Cytomegalovirus (RhCMV) has therefore emerged as a highly relevant experimental model for pathogenesis and vaccine development due to its close evolutionary relationship to human CMV (HCMV). To date, most in vivo experiments performed with RhCMV employed strain 68-1 cloned as bacterial artificial chromosome (BAC). However, the complete genome sequence of the 68-1 BAC has not been determined. Furthermore, the gene content of the RhCMV genome is unknown and previous open reading frame (ORF) predictions relied solely on uninterrupted ORFs with an arbitrary cutoff of 300bp. To obtain a more precise picture of the actual proteins encoded by the most commonly used molecular clone of RhCMV we re-evaluated the RhCMV 68-1 BAC-genome by whole genome shotgun sequencing and determined the protein content of the resulting RhCMV virions by proteomics. By additionally comparing the RhCMV genome to that of several closely related Old World Monkey (OWM) CMVs we were able to filter out many unlikely ORFs and obtain a simplified map of the RhCMV genome. This comparative genomics analysis eliminated many genes previously characterized as RhCMV-specific while consolidating a high conservation of ORFs among OWM-CMVs and between RhCMV and HCMV. Moreover, virion proteomics independently validated the revised ORF predictions since only proteins encoded by predicted ORFs could be detected. Taken together these data suggest a much higher conservation of genome and virion structure between CMVs of humans, apes and OWMs than previously assumed. Remarkably, BAC-derived RhCMV is able to establish and maintain persistent infection despite the lack of multiple genes homologous to HCMV genes involved in tissue tropism.

  7. Reevaluation of the thyroidal radioactive iodine uptake test, with special reference to reversible primary hypothyroidism with elevated thyroid radioiodine uptake

    Energy Technology Data Exchange (ETDEWEB)

    Okamura, K.; Sato, K.; Ikenoue, H.; Yoshinari, M.; Nakagawa, M.; Kuroda, T.; Fujishima, M.

    1988-10-01

    The clinical significance of the thyroidal radioactive iodine uptake (RAIU) test was reevaluated in patients with various thyroid disorders. Compared with 262 normal subjects or 194 patients with euthyroid diffuse goiter with normal serum TSH levels, RAIU values were significantly higher in 100 patients with latent primary hypothyroidism (serum TSH, 5-40 mU/L). In 126 patients with overt primary hypothyroidism (serum TSH, greater than 40 mU/L), RAIU values were either extremely high (49 patients with reversible hypothyroidism and 10 patients with postpartum hypothyroidism) or low (67 patients with irreversible hypothyroidism). The increase in RAIU values in latent, or reversible overt hypothyroidism was TSH dependent, and there was a good correlation between RAIU values and serum TSH levels (r = 0.6203; P less than 0.001). In overt primary hypothyroidism, spontaneous recovery of thyroid function during iodide restriction alone occurred in 52 of 53 patients with RAIU values above 35%, in only 7 of 23 patients with RAIU values between 10-35%, and in none of 50 patients with RAIU below 10%. Thus, recovery was predicted by high RAIU values (P less than 0.001; prediction rate, 91.4%). Goiter was found in about 80% of the patients with reversible hypothyroidism, compared with only 34% of the patients with irreversible hypothyroidism. Recovery of thyroid function during iodide restriction also occurred in 71% of the patients with latent hypothyroidism. However, RAIU measurements did not predict the prognosis of patients with latent hypothyroidism. We conclude that iodine-induced reversible hypothyroidism is common in our patient population, and RAIU measurements may be helpful in determining the prognosis of patients with overt primary hypothyroidism.

  8. Comparative experimental re-evaluation of the two implanting methods of silicone gel testicular prostheses in beagle dogs

    Directory of Open Access Journals (Sweden)

    Chen Peng

    2011-04-01

    Full Text Available Abstract Background Testicular prosthesis has been applied clinically for decades, and implantation of testis prosthesis under the tunica albuginea has been considered to be the standard method in the most of the reports. However, postoperative scrotal appearance, the mobilization and the palpitation of the prosthesis are not always satisfactory to all the patients. Modifications in surgical techniques might be necessary to bring improvements to the clinical outcomes in testicular prosthesis implantation. Findings In a group of 9 beagle dogs in this study, an orchiectomy succeeded with a testicular prosthesis implantation under the tunica vaginalis, and a complete mechanical denudation of the testicular parenchyma succeeded with an implantation under the tunica albuginea were performed, respectively. Histopathological evaluations of the scrotal tissues and the implants, which were made at the end of the follow-up, showed that all the tested animals lived uneventful lives during the follow-up period, and no rejections or infections were found. Prostheses implanted under the tunica vaginalis showed a more satisfying mobilization and palpation than those implanted under the tunica albuginea. Chronic inflammation in the para-prosthesis tissues with vascular proliferation and fibrinogenesis were more common in the "under tunica albuginea" group than that in the "under tunica vaginalis" group, although differences in fibrinogenesis between the two groups were found to be statistically insignificant. Conclusions In this comparative study, we have re-evaluated the two most popular implantation methods of testicular prosthesis, the "under the tunica albuginea" and the "under the tunica vaginalis" pathways, in animal models. We found that the testicular prosthesis were all well tolerated, but the prosthesis implanted under the tunica vaginalis showed a more satisfying result concerning appearance, palpability, and histopathological findings than that of

  9. Re-evaluation of benefit-risk analysis for mammographic screening in Japan using prevalence model and BEIR VII report

    International Nuclear Information System (INIS)

    The risk of radiation exposure associated with mammography in breast cancer screening must be considered. In this study, we re-evaluated the benefit vs. risk of the mammographic procedure used for breast cancer screening in Japan, assuming a screening interval of 2 years with 2 mammography views for women aged 40-49 years and 1 view for those aged 50 years or more. We also used a new breast tissue weighting factor defined by ICRP2007 and the life-time mortality coefficient defined by BEIR. The effective radiation dose used in mammography was assumed to be 0.72 mSv and 0.36 mSv for women aged 40-49 and 50 years or more respectively. The risk was expressed as loss of life expectancy (person-day) due to a single screening test. On the other hand, the benefit of screening was calculated on the basis of the number of lives saved by a stage shift of breast cancer detected by screening and then multiplying by the average life expectancy. Thus the benefit was expressed as the gain of life expectancy (person-day) due to a single screening. Finally, the benefit/risk ratio was obtained as: gain of life expectancy/loss of life expectancy as a function of age at which the benefit/risk ratio exceeded 1.0. In this study we showed that the benefit/risk ratio exceeds 1.0 from age of 25 years old or more in Japanese breast cancer screening, and so our screening is justified because the lowest age for the screenee is set at 40 years old. (author)

  10. improbable molecular results and the need to reevaluate a priori genetic risks: A report of 2 neuromuscular disorders

    Energy Technology Data Exchange (ETDEWEB)

    Giardine, R.M.; Rose, N.C.; Fischbeck, K.H. [Univ. of Pennsylvania Medical Center, Philadelphia (United States)] [and others

    1994-09-01

    Case 1: A 27-year-old woman whose brother and deceased father were diagnosed with myotonic dystrophy presented for preconceptional counseling. Three other first and second degree relatives were judged clinically affected on the basis of myotonia by positive electromyelograms (EMGs). The proband appeared to be clinically affected with mild percussion myotonia and a positive EMG. Initial studies by linkage analysis required postulation that the at-risk chromosome 19 inherited by the patient and her brother had undergone recombination in the brother between 2 very closely linked RFLP markers. Conclusion: Molecular testing did not support a unifying diagnosis for myotonia in this family. In addition to one classic example of myotonic dystrophy, it is possible a milder form of myotonia is also segregating in this pedigree. Case 2: The maternal aunt of a young man with Becker`s muscular dystrophy (BMD) presented for reproductive counseling. Serum CK values were elevated in her mother, who shared an X chromosome haplotype with the affected grandson and was judged an obligate carrier. The aunt was judged a likely carrier because of elevated serum CK values. Three maternal uncles, including ones with the same X chromosome haplotype as the affected nephew, were clinically normal. Finally, dosage analysis for dystrophin exons deleted in the grandson showed the grandmother and aunt to be non-carriers, but the mother of the affected boy to be a somatic carrier. The grandmother and aunt are not BMD carriers. Since the elevated CK levels do not segregate with the affected X chromosome, they may reflect autosomal inheritance or nongenetic influences; in either case their clinical significance is uncertain. These cases reinforce the importance of periodic reevaluation of initial genetic assignments, particularly when rare events must be invoked to explain molecular studies.

  11. Reevaluating the age of the Walden Creek Group and the kinematic evolution of the western Blue Ridge, southern Appalachians

    Science.gov (United States)

    Thigpen, J. Ryan; Hatcher, Robert D.; Kah, Linda C.; Repetski, John E.

    2016-01-01

    An integrated synthesis of existing datasets (detailed geologic mapping, geochronologic, paleontologic, geophysical) with new paleontologic and geochemical investigations of rocks previously interpreted as part of the Neoproterozoic Walden Creek Group in southeastern Tennessee suggest a necessary reevaluation of the kinematics and structural architecture of the Blue Ridge Foothills. The western Blue Ridge of Tennessee, North Carolina, and Georgia is composed of numerous northwest-directed early and late Paleozoic thrust sheets, which record pronounced variation in stratigraphic/structural architecture and timing of metamorphism. The detailed spatial, temporal, and kinematic relationships of these rocks have remained controversial. Two fault blocks that are structurally isolated between the Great Smoky and Miller Cove-Greenbrier thrust sheets, here designated the Maggies Mill and Citico thrust sheets, contain Late Ordovician-Devonian conodonts and stable isotope chemostratigraphic signatures consistent with a mid-Paleozoic age. Geochemical and paleontological analyses of Walden Creek Group rocks northwest and southeast of these two thrust sheets, however, are more consistent with a Late Neoproterozoic (550–545 Ma) depositional age. Consequently, the structural juxtaposition of mid-Paleozoic rocks within a demonstrably Neoproterozoic-Cambrian succession between the Great Smoky and Miller Cove-Greenbrier thrust sheets suggests that a simple foreland-propagating thrust sequence model is not applicable in the Blue Ridge Foothills. We propose that these younger rocks were deposited landward of the Ocoee Supergroup, and were subsequently plucked from the Great Smoky fault footwall as a horse, and breached through the Great Smoky thrust sheet during Alleghanian emplacement of that structure.

  12. Re-evaluation of the lifetimes of the major CFCs and CH3CCl3 using atmospheric trends

    Directory of Open Access Journals (Sweden)

    J. W. Elkins

    2012-09-01

    Full Text Available Since the Montreal Protocol on substances that deplete the ozone layer and its amendments came into effect, growth rates of the major ozone depleting substances (ODS, particularly CFC-11, -12 and -113 and CH3CCl3, have declined markedly, paving the way for global stratospheric ozone recovery. Emissions have now fallen to relatively low levels, therefore the rate at which this recovery occurs will depend largely on the atmospheric lifetime of these compounds. The first ODS measurements began in the early 1970s along with the first lifetime estimates calculated by considering their atmospheric trends. We now have global mole fraction records spanning multiple decades, prompting this lifetime re-evaluation. Using surface measurements from the Advanced Global Atmospheric Gases Experiment (AGAGE and the National Oceanic and Atmospheric Administration Global Monitoring Division (NOAA GMD from 1978 to 2011, we estimated the lifetime of CFC-11, CFC-12, CFC-113 and CH3CCl3 using a multi-species inverse method. The CFC-11 lifetime of 45 yr, currently recommended in the World Meteorological Organisation (WMO Scientific Assessment of Ozone Depletion, lies at the lower uncertainty bound of our estimates which are 524066 yr (1-sigma uncertainty when AGAGE data were used, and 504066 yr when the NOAA network data were used. Our derived lifetime for CFC-113 is higher than the WMO estimates of 85 yr (10488123 using AGAGE, 10387122 using NOAA. Our estimates of the lifetime of CFC-12 and CH3CCl3 agree well with other recent estimates being 10885137 and 10484135 yr (CFC-12, AGAGE and NOAA, respectively and 5.24.85.6 and 5.24.85.7 yr (CH3CCl3, AGAGE and NOAA, respectively.

  13. Predictors of academic performance of first year dental undergraduates in Sri Lanka: a re-evaluation following curriculum changes.

    Science.gov (United States)

    Ariyasinghe, S; Pallegama, R

    2013-02-01

    The dentistry course in Sri Lanka is conducted in English, a second language for its students. A decade ago, English language proficiency was the key factor in predicting the academic performance of first year dental undergraduates. Since then, changes have been introduced to the teaching programme and examination format to minimise the effect of language proficiency on their performance. This study aimed at re-evaluating the factors influencing academic performance in a similar academic cohort. A total of 306 first year students in five consecutive academic years ranging in age from 20 to 24 years (77% of the total number registered, 36.3% men) were recruited, and a questionnaire was used to collect data regarding demographics, previous academic ability and perceived levels of difficulty of the first year course, English language and its sub-skills. Performances of the English language test and cumulative GPA of the first year course were used as objective indicators of language competency and academic performance respectively. The data were analysed using SPSS 11.5. Hierarchical Regression Analysis revealed that English language proficiency, gender and previous academic ability were the significant predictors of GPA. Students who received a lower GPA perceived English as considerably more difficult compared to the academic course itself; however, students who obtained a higher GPA perceived the opposite. Students' language competency remains the major predictor of academic performance, although previous academic ability and gender emerge as significant predictors. The perceived difficulty, however, of the dental course and of studying in English may also be predictors of student academic performance.

  14. Re-evaluation of the lifetimes of the major CFCs and CH3CCl3 using atmospheric trends

    Directory of Open Access Journals (Sweden)

    M. Rigby

    2013-03-01

    Full Text Available Since the Montreal Protocol on Substances that Deplete the Ozone Layer and its amendments came into effect, growth rates of the major ozone depleting substances (ODS, particularly CFC-11, -12 and -113 and CH3CCl3, have declined markedly, paving the way for global stratospheric ozone recovery. Emissions have now fallen to relatively low levels, therefore the rate at which this recovery occurs will depend largely on the atmospheric lifetime of these compounds. The first ODS measurements began in the early 1970s along with the first lifetime estimates calculated by considering their atmospheric trends. We now have global mole fraction records spanning multiple decades, prompting this lifetime re-evaluation. Using surface measurements from the Advanced Global Atmospheric Gases Experiment (AGAGE and the National Oceanic and Atmospheric Administration Global Monitoring Division (NOAA GMD from 1978 to 2011, we estimated the lifetime of CFC-11, CFC-12, CFC-113 and CH3CCl3 using a multi-species inverse method. A steady-state lifetime of 45 yr for CFC-11, currently recommended in the most recent World Meteorological Organisation (WMO Scientific Assessments of Ozone Depletion, lies towards the lower uncertainty bound of our estimates, which are 544861 yr (1-sigma uncertainty when AGAGE data were used and 524561 yr when the NOAA network data were used. Our derived lifetime for CFC-113 is significantly higher than the WMO estimates of 85 yr, being 10999121 (AGAGE and 10997124 (NOAA. New estimates of the steady-state lifetimes of CFC-12 and CH3CCl3 are consistent with the current WMO recommendations, being 11195132 and 11295136 yr (CFC-12, AGAGE and NOAA respectively and 5.044.925.20 and 5.044.875.23 yr (CH3CCl3, AGAGE and NOAA respectively.

  15. Re-evaluation of the lifetimes of the major CFCs and CH3CCl3 using atmospheric trends

    Science.gov (United States)

    Rigby, M.; Prinn, R. G.; O'Doherty, S.; Montzka, S. A.; McCulloch, A.; Harth, C. M.; Mühle, J.; Salameh, P. K.; Weiss, R. F.; Young, D.; Simmonds, P. G.; Hall, B. D.; Dutton, G. S.; Nance, D.; Mondeel, D. J.; Elkins, J. W.; Krummel, P. B.; Steele, L. P.; Fraser, P. J.

    2013-03-01

    Since the Montreal Protocol on Substances that Deplete the Ozone Layer and its amendments came into effect, growth rates of the major ozone depleting substances (ODS), particularly CFC-11, -12 and -113 and CH3CCl3, have declined markedly, paving the way for global stratospheric ozone recovery. Emissions have now fallen to relatively low levels, therefore the rate at which this recovery occurs will depend largely on the atmospheric lifetime of these compounds. The first ODS measurements began in the early 1970s along with the first lifetime estimates calculated by considering their atmospheric trends. We now have global mole fraction records spanning multiple decades, prompting this lifetime re-evaluation. Using surface measurements from the Advanced Global Atmospheric Gases Experiment (AGAGE) and the National Oceanic and Atmospheric Administration Global Monitoring Division (NOAA GMD) from 1978 to 2011, we estimated the lifetime of CFC-11, CFC-12, CFC-113 and CH3CCl3 using a multi-species inverse method. A steady-state lifetime of 45 yr for CFC-11, currently recommended in the most recent World Meteorological Organisation (WMO) Scientific Assessments of Ozone Depletion, lies towards the lower uncertainty bound of our estimates, which are 544861 yr (1-sigma uncertainty) when AGAGE data were used and 524561 yr when the NOAA network data were used. Our derived lifetime for CFC-113 is significantly higher than the WMO estimates of 85 yr, being 10999121 (AGAGE) and 10997124 (NOAA). New estimates of the steady-state lifetimes of CFC-12 and CH3CCl3 are consistent with the current WMO recommendations, being 11195132 and 11295136 yr (CFC-12, AGAGE and NOAA respectively) and 5.044.925.20 and 5.044.875.23 yr (CH3CCl3, AGAGE and NOAA respectively).

  16. Re-evaluation of the formalin-ether sedimentation method for the improvement of parasite egg recovery efficiency.

    Science.gov (United States)

    Sato, C; Rai, S K; Uga, S

    2014-09-01

    The formalin-ether sedimentation (FES) method is considered as reliable method of fecal examination for the detection of parasites. In this study, we re-evaluated several aspects of FES such as (i) pretreatment of feces; (ii) filtration of fecal suspensions; (iii) test-tube material and (iv) substitution of ether by other organic solvents as to see an improvement in parasite egg recovery. The egg count was represented by the number of ova detected per 100 μg of sediment. Pre-treatment of feces with formalin (pH 7) increased egg detection rate remarkably compared with original FES method. Use of three layers of gauze dramatically reduced the sediment in the final product, and led to an increase in the number of ova detected. Use of polypropylene test tubes instead of glass test tubes also increased the number of egg detection. None of the organic solvents used to replace the ether produced better results. Based on these findings, we proposed a modified FES procedure. Further, we also compared the parasite positive rate and the number of ova recovered by using original FES and the modified FES procedures by examining 112 fecal samples collected from school children of parasite endemic area in Nepal. Feces collected from Nepal had many parasite ova, and these fecal samples barely displayed false-negative results even by method with low sensitivity. When the mean number of Hemenolepis nana, hookworm, T. trichiura, and A. lumbricoides ova recovered by original FES and the modified FES methods was compared, the values obtained by modified FES were superior (higher). This result suggested that the modified FES is effective and better for the recovery of parasite ova in areas of low-intensity parasitic infection.

  17. Thanatos--a reevaluation.

    Science.gov (United States)

    Wallace, E R

    1976-11-01

    Freud's most controversial tenet is the death instinct. Although it appears full blown in 1920, it was doubtless nurtured for years in his mind. In its indissoluble relation to the repetition compulsion and Nirvana principle, Thanatos is the bedrock of much of Freud's later philosophy. This paper is an examination of the motivations for the idea, an exegesis of Freud's writings on the subject, and a review of critical opinion. PMID:792927

  18. Indications of postoperative irradiation and prognosis in cancer of the uterine cervix; Reevaluation of its indications from prognosis

    Energy Technology Data Exchange (ETDEWEB)

    Shiromizu, Kenji; Ishimoto, Kazuya; Kobayashi, Kouichi; Onda, Takashi; Nishimura, Toshinobu; Takahashi, Michiko; Matsuzawa, Masumi; Sakura, Mizuyoshi (Saitama Prefectural Cancer Center, Ina (Japan))

    1993-09-01

    This study reevaluated indications of postoperative radiotherapy for cancer of the uterine cervix from the viewpoint of prognosis and side effects. The subjects were 441 patients treated for clinical stage Ib or more from 1976 through 1987. According to the degree of cancer involvement, the patients were classified as cancer involvement to one third of the uterine cervix (group A), two thirds (group B), more than two thirds (group C), and the parauterine tissue (group D). Postoperative total pelvic irradiation of 40-50 Gy was given to patients with vascular involvement in groups A and B, all patients in groups C and D, and patients with lymph node (LN) metastases. Histology revealed squamous cell carcinoma (SCC) in 354 patients and adenocarcinoma or adenomatous SCC in the other 87. In LN negative SCC patients (n=268), the recurrence rate for irradiated patients was 16.7% in group A, 13.6% in group B, and 21.0% in group C; the corresponding figures for non-irradiated patients were 9.6%, 8.3%, and 50.0%, respectively. In all LN positive SCC patients treated with irradiation (n=86), it was 0% in group A, 37.5% in group B, 45.7% in group C, and 54.8% in group D. The more cancer was involved, the higher the recurrence rate was in both negative and positive SCC patients. The 5-year survival rate in LN negative SCC patients was 100% and 97.2% for irradiated and non-irradiated patients, respectively, in group A, 100% and 97.0% in group B, and 89.7% and 50.0% in group C. Postoperative irradiation seemed to be unnecessary for LN negative patients in groups A and B. In SCC patients with either musculi iliacus involvement or primary LN metastases, prognosis was independent of the presence or absence of irradiation. The incidence of edema in the lower extremities and vulva was 0% for irradiation without LN dissection, 10.2% for LN dissection without irradiation, and 51.3% for both irradiation and LN dissection. (N.K.).

  19. The Reevaluation of MIBI as the Ligand of 99mTc-MIBI Radiopharmaceutical for Myocardial Imaging

    Directory of Open Access Journals (Sweden)

    Z. Nurlaila

    2008-01-01

    Full Text Available Methoxy isobutyl isonitrile labelled with technetium-99m (99mTc radionuclide can be used for the evaluation of acute myocardial infarction. The 99mTc-MIBI radiopharmaceutical is available in the lyophilized-kit, which is separately packed with its radionuclide. Recently, in CNTMR-BATAN Bandung, 99mTc-MIBI radiopharmaceutical was prepared using MIBI ligand synthesized in 1996 as lyophilized-kits having the radiochemical purity less than 90 % and not accumulated in the myocardium. It could be caused by several factors, among others were technical preparation of lyophilized dry-kit and the quality of MIBI; therefore the reevaluation of the ligand for the quality improvement was needed. Firstly, MIBI ligand was recristallized. It was found that MIBI as [Cu(MIBI4]BF4 salt was a glassy solid with the melting point of 98 -99 oC. The infra red analysis showed the presence of spectra vibration at 1085, 1180 cm-1 and 2180, 2220 cm-1 for –OCH3 and N≡C groups, respectively. The preparation of 99mTc-MIBI was performed by adding 99mTc radionuclide into new MIBI liquid-kit, then boiled in water bath for minimum period of 10 minutes. The radiochemical purity of 99mTc-MIBI was analysed by thin layer chromatographic method using absolute ethanol as a mobile phase. The pre-clinical evaluation was observed in Wistar rat and clinical studies were performed in volunter using gamma camera. It is revealed that the radiochemical purity of more than 90 % i.e. 96.83 ± 1.43 % was still stable until 24 hours storage at room temperature. The stability studies of 99mTc-MIBI in human blood plasma showed that in 6 hours, the radiochemical purity was decreased to 90.89 ± 2.90 %. Clinical application of 99mTc-MIBI with tomography techniques using gamma camera showed the distinct accumulation of radioactivity in the heart.

  20. A re-evaluation of the Italian historical geomagnetic catalogue: implications for paleomagnetic dating at active Italian volcanoes

    Directory of Open Access Journals (Sweden)

    F. D'Ajello Caracciolo

    2011-06-01

    Full Text Available Paleomagnetism is proving to represent one of the most powerful dating tools of volcanics emplaced in Italy during the last few centuries/millennia. This method requires that valuable proxies of the local geomagnetic field (paleosecular variation ((PSV are available. To this end, we re-evaluate the whole Italian geomagnetic directional dataset, consisting of 833 and 696 declination and inclination measurements, respectively, carried out since 1640 AD at several localities. All directions were relocated via the virtual geomagnetic pole method to Stromboli (38.8° N, 15.2° E, the rough centre of the active Italian volcanoes. For declination-only measurements, missing inclinations were derived (always by pole method by French data (for period 1670–1789, and by nearby Italian sites/years (for periods 1640–1657 and 1790–1962. Using post-1825 declination values, we obtain a 0.46 ± 0.19° yr−1 westward drift of the geomagnetic field for Italy. The original observation years were modified, considering such drift value, to derive at a drift-corrected relocated dataset. Both datasets were found to be in substantial agreement with directions derived from the field models by Jackson et al. (2000 and Pavon-Carrasco et al. (2009. However, the drift-corrected dataset minimizes the differences between the Italian data and both field models, and eliminates a persistent 1.6° shift of 1933–1962 declination values from Castellaccio with respect to other nearly coeval Italian data. The relocated datasets were used to calculate two post-1640 Italian SV curves, with mean directions calculated every 30 and 10 years before and after 1790, respectively. The curve comparison suggests that both available field models yield the best available SV curve to perform paleomagnetic dating of 1600–1800 AD Italian volcanics, while the Italian drift-corrected curve is probably preferable for the 19th century. For the 20th century, the global model by

  1. Re-evaluation of the Optimum Dietary Vitamin C Requirement in Juvenile Eel, Anguilla japonica by Using L-ascorbyl-2-monophosphate

    OpenAIRE

    Bae, Jun-Young; Park, Gun-Hyun; Yoo, Kwang-Yeol; Lee, Jeong-Yeol; Kim, Dae-Jung; Bai, Sungchul C.

    2012-01-01

    This study was conducted to re-evaluate the dietary vitamin C requirement in juvenile eel, Anguilla japonica by using L-ascorbyl-2-monophosphate (AMP) as the vitamin C source. Five semi-purified experimental diets were formulated to contain 0 (AMP0), 30 (AMP24), 60 (AMP52), 120 (AMP108) and 1,200 (AMP1137) mg AMP kg-1 diet on a dry matter basis. Casein and defatted fish meal were used as the main protein sources in the semi-purified experimental diets. After a 4-week conditioning period, fish...

  2. Re-evaluating the role of voluntary organisations: merchant networks, the Baltic and the expansion of European long-distance trade

    OpenAIRE

    Sahle, Esther

    2010-01-01

    Based on a letter book of the London Baltic merchant Michael Mitford dating 1703-1707 this paper argues that the ability of merchant networks to secure property rights in long distance trade must be re-evaluated. Contrary to the argument of the New Institutional Economists, these were not inferior to the nation state in facilitating the expansion of trade and thereby Smithean growth. It is shown that Mitford's network did not limit membership by non-economic criteria but adapted to the needs ...

  3. New Markov-autocorrelation indices for re-evaluation of links in chemical and biological complex networks used in metabolomics, parasitology, neurosciences, and epidemiology.

    Science.gov (United States)

    González-Díaz, Humberto; Riera-Fernández, Pablo

    2012-12-21

    The development of new methods for the computational re-evaluation of links in chemical and biological complex networks is very important to save time and resources. The Moreau-Broto autocorrelation indices (MBis) are well-known topological indices (TIs) used in QSAR/QSPR studies to encode the structural information contained in molecular graphs. In addition, MBis and similar autocorrelation measures have been used to study other systems like, for example, proteins. In the present work, MBis are combined with Markov chains to develop a general class of stochastic MBis of order k (MB(k)) that is used to encode the structural information contained in different types of large complex networks. The MB(k) values obtained for the nodes (centralities) of these networks are used as input variables to seek QSPR-like equations (by means of linear discriminant analysis) in which the outputs are numerical scores S(L(ij)) that allow us to discriminate between connected and nonconnected nodes and therefore re-evaluate the connectivity of the whole network. The models developed in this work produced the following results in terms of overall accuracy for network reconstruction: metabolic networks (72.10%), parasite-host networks (88.70%), CoCoMac brain cortex coactivation network (81.89%), and fasciolosis spreading network (86.39%).

  4. [A case of carbon monoxide poisoning by explosion of coal mine presenting as visual agnosia: re-evaluation after 40 years].

    Science.gov (United States)

    Takaiwa, Akiko; Yamashita, Kenichiro; Nomura, Takuo; Shida, Kenshiro; Taniwaki, Takayuki

    2005-11-01

    We re-evaluated a case of carbon monoxide poisoning presenting as visual agnosia who had been injured by explosion of Miike-Mikawa coal mine 40 years ago. In an early stage, his main neuropsychological symptoms were visual agnosia, severe anterograde amnesia, alexia, agraphia, constructional apraxia, left hemispatial neglect and psychic paralysis of gaze, in addition to pyramidal and extra pyramidal signs. At the time of re-evaluation after 40 years, he still showed visual agnosia associated with agraphia and constructional apraxia. Concerning visual agnosia, recognition of the real object was preserved, while recognition of object photographs and picture was impaired. Thus, this case was considered to have picture agnosia as he could not recognize the object by pictorial cues on the second dimensional space. MRI examination revealed low signal intensity lesions and cortical atrophy in the bilateral parieto-occipital lobes on T1-weighted images. Therefore, the bilateral parieto-occipital lesions are likely to be responsible for his picture agnosia.

  5. A case of carbon monoxide poisoning by explosion of coal mine presenting as visual agnosia: re-evaluation after 40 years

    Energy Technology Data Exchange (ETDEWEB)

    Takaiwa, A.; Yamashita, K.; Nomura, T.; Shida, K.; Taniwaki, T. [Kyushu University, Fukuoka (Japan). Department of Neurology, Graduate School of Medical Science

    2005-11-15

    We re-evaluated a case of carbon monoxide poisoning presenting as visual agnosia who had been injured by explosion of Miike-Mikawa coal mine 40 years ago. In an early stage, his main neuropsychological symptoms were visual agnosia, severe anterograde amnesia, alexia, agraphia, constructional apraxia, left hemispatial neglect and psychic paralysis of gaze, in addition to pyramidal and extra pyramidal signs. At the time of re-evaluation after 40 years, he still showed visual agnosia associated with agraphia and constructional apraxia. Concerning visual agnosia, recognition of the real object was preserved, while recognition of object photographs and picture was impaired. Thus, this case was considered to have picture agnosia as he could not recognize the object by pictorial cues on the second dimensional space. MRI examination revealed low signal intensity lesions and cortical atrophy in the bilateral parieto-occipital lobes on T1-weighted images. Therefore, the bilateral parieto-occipital lesions are likely to be responsible for his picture agnosia.

  6. A safety re-evaluation of the AVR pebble bed reactor operation and its consequences for future HTR concepts

    Energy Technology Data Exchange (ETDEWEB)

    Moormann, R.

    2008-06-15

    The AVR pebble bed reactor (46 MW{sub th}) was operated 1967-88 at coolant outlet temperatures up to 990 C. A principle difference of pebble bed HTRs as AVR to conventional reactors is the continuous movement of fuel element pebbles through the core which complicates thermohydraulic, nuclear and safety estimations. Also because of a lack of other experience AVR operation is still a relevant basis for future pebble bed HTRs and thus requires careful examination. This paper deals mainly with some insufficiently published unresolved safety problems of AVR operation and of pebble bed HTRs but skips the widely known advantageous features of pebble bed HTRs. The AVR primary circuit is heavily contaminated with metallic fission products (Sr-90, Cs-137) which create problems in current dismantling. The amount of this contamination is not exactly known, but the evaluation of fission product deposition experiments indicates that the end of life contamination reached several percent of a single core inventory, which is some orders of magnitude more than precalculated and far more than in large LWRs. A major fraction of this contamination is bound on graphitic dust and thus partly mobile in depressurization accidents, which has to be considered in safety analyses of future reactors. A re-evaluation of the AVR contamination is performed here in order to quantify consequences for future HTRs (400 MW{sub th}). It leads to the conclusion that the AVR contamination was mainly caused by inadmissible high core temperatures, increasing fission product release rates, and not - as presumed in the past - by inadequate fuel quality only. The high AVR core temperatures were detected not earlier than one year before final AVR shut-down, because a pebble bed core cannot yet be equipped with instruments. The maximum core temperatures are still unknown but were more than 200 K higher than calculated. Further, azimuthal temperature differences at the active core margin of up to 200 K were

  7. Prevalence of Campylobacter, Arcobacter, Helicobacter, and Sutterella spp. in human fecal samples as estimated by a reevaluation of isolation methods for Campylobacters

    DEFF Research Database (Denmark)

    Engberg, J.; On, Stephen L.W.; Harrington, C.S.;

    2000-01-01

    CCDA recovered significantly more thermophilic Campylobacter spp. than Skirrow's medium (P = 0.0034). No significant difference between Skirrow's medium and CAT agar was observed in this study. Another six taxa were identified, namely, Campylobacter concisus, Campylobacter curvus-like bacteria, Arcobacter......The aims of this study were to investigate the prevalence of campylobacteria including Campylobacter jejuni subsp. jejuni (C. jejuni) and Campylobacter coli in human clinical samples and in samples from healthy individuals and to reevaluate the efficacies of conventional selective methods...... for isolation of Campylobacter spp. Two charcoal-based selective media, modified charcoal cefoperazone deoxycholate agar (mCCDA) and cefoperazone-amphotericin-teicoplanin (CAT) agar, were compared with Skirrow's blood-based medium and with a filter method (filter) applied to a yeast-enriched blood agar. A total...

  8. Exploring Ideational Metafunction in Helon Habila’s Oil on Water: A re-evaluation and redefinition of African Women’s Personality and Identity through Literature

    Directory of Open Access Journals (Sweden)

    Léonard A. Koussouhon

    2015-09-01

    Full Text Available This article aims at applying some of the principles guiding Systemic Functional Grammar (SFG to Helon Habila’s Oil On Water (2011. One of the major principles of Systemic Linguistics is that the exploration of the Transitivity properties (processes, participants, and circumstances in/of a text can give a full insight into how the writer encodes experiential meaning therein (Koussouhon & Allagbe, 2013 and Koussouhon & Dossoumou, 2014. This implies that the analysis in/of a text can reveal how its language is organized to express the speaker’s or narrator’s personal experience, views, etc., thereby contributing to the meaning of personal and interpersonal interaction. Given the importance of social role played by language in any societal situation, the experiential meaning of a structural choice is not determined only by Lexico-grammar, but also by contextual factors (Gledhill, 2011. By applying the theory of the grammar of experiential meaning to Helon Habila’s Oil On Water (2011, this article attempts to auscultate African society’s emerging perception of gender identity as it affects and re-presents women. By borrowing the way the writer encodes his experience (or fictional reality via the medium of language to affirm male writers’ support to the trend, this article is proving the propriety and relevance of womanist theory by re-evaluating and re-defining African women’s identity and personality through the novel under study.    Keywords: systemic functional grammar (SFG, experiential meaning, re-evaluation, redefinition, Womanism, women’s identity

  9. Seismic re-evaluation of EDF Bugey 900 PWR nuclear power plant in the frame of the 3rd periodic safety review

    Energy Technology Data Exchange (ETDEWEB)

    Viallet, E.; Labbe, P.; Gallitre, E.; Nadjarian, A.; Vandeputte, D.; Ravet, S.; Humbert, N. [EDF - SEPTEN, 12-14 avenue Dutrievoz, 69628 Villeurbanne Cedex (France); Durouchoux, C. [EDF - TEGG, 905 Avenue du Camp de Menthe, 13097 AIX-EN-PROVENCE CEDEX 02 (France); Pascal, P.; Blanchard, M.T.; Pons, Y. [EDF - SEPTEN, 12-14 avenue Dutrievoz, 69628 Villeurbanne Cedex (France); Jadot, H., E-mail: hugo.jadot@edf.f [EDF - SEPTEN, 12-14 avenue Dutrievoz, 69628 Villeurbanne Cedex (France); Louche, V.; Nicolet, S. [EDF - CIPN, 140 Avenue Viton, 13401 Marseille Cedex 20 (France)

    2010-06-15

    As compared to the previous Periodic Safety Review (PSR), main features of the seismic facet of the Bugey NPP (France) 3rd PSR are relating to (i) a 45% increase of the Review Level Earthquake (RLE), (ii) a dramatic increase of computer code capabilities and (iii) a certain evolution of safety standards. This paper presents the method implemented to cope with this situation. Seismic input motion is determined according to an updated Basic Safety Rule published in 2001. Concerning buildings, 3D models are established, accounting for torsion effects, which were not represented by the initial design spring-mass models; analyses are carried out as per the IAEA methodology, accounting for ductile capacity through a F{sub m}u factor; finally the major impact of the seismic re-evaluation is a reinforcement of electrical building, so that it is less torsion sensitive. Regarding equipment, the concept of Safe Shutdown Equipment List (SSEL) is enlarged to all the Safety Related Equipment List (SREL). An equipment hierarchy classification is introduced, based on two complementary approaches: a system approach that identifies components associated to success paths for a safe shutdown, and a ruggedness approach that considers experience feedback about seismic behavior of components. On these bases, all the safety related equipments are classified in two categories: High Hierarchy level (HH) and Medium Hierarchy level (MH). MH equipment is mainly verified by walkdown, whereas HH equipment is by calculation, taking benefit from design margins. The optimization procedures enable to focus on the more relevant components. Bugey NPP seismic re-evaluation stands out by its realistic calculation chain and the completeness of its assessment, and eventually, the 3rd PSR is an opportunity to improve the plant safety and increase design margins.

  10. A morphological re-evaluation of the taxonomic status of the genus Pellegriniodendron (Harms) J. Léonard (Leguminosae-Caesalpinioideae-Detarieae) and its inclusion in Gilbertiodendron J. Léonard.

    NARCIS (Netherlands)

    Estrella, de la M.; Devesa, J.A.; Wieringa, J.J.

    2012-01-01

    The taxonomic status of the genus Pellegriniodendron J. Léonard (Leguminosae, Caesalpinioideae), which consists in one tree species endemic to West Central tropical Africa, is re-evaluated. Based on our morphological comparison and on published phylogenetic studies, we conclude that P. diphyllum sho

  11. Literature re-evaluation on antipyretic effect of Chinese heat-clearing herbs%清热药解热作用的文献再评价

    Institute of Scientific and Technical Information of China (English)

    张涓; 李晓会; 马丽娜; 张恩户

    2014-01-01

    Literally re-evaluate the antipyretic effect of heat-clearing herbs. Choose 20 taste heat-clearing herbs from the Chinese Medicine materials(China press of traditional Chinese medicine,2009)as evaluation objects,through the consulting,induction,sorting the literatures about heat-clearing herbs antipyretic effect published before 2013. According to repeating and integrating evaluation prin-ciples,Chinese medicine antipyretic role of assessment standard is self-made. Literally re-evaluate the heat-clearing herbs of antipyretic role in order to determine its reliability. The functions of radix scutellariae,bupleurum,artemisia annua,radix isatidis,honeysuckle,and forsythia are exact. Experiments on the basis of Rhizoma coptidis,barbed skullcap herb,cortex lycii radicis,honeysuckle,radix scrophu-lariae,gypsum,folium isatidis,cortex moutan and gardenia are inadequate. Cortex phellodendri doesn’t have antipyretic effect. There is no related research literature of rhizoma anemarrhenae,sophora,dandelion,radix rehmanniae,and radix paeoniae rubra.%对清热药药理作用中的解热作用进行文献再评价。选择《中药学》(中国中医药出版社,2009)教材中20味清热药作为评价对象,通过查阅、归纳、整理2013年以前公开发表的有关清热药解热作用的研究文献,根据重复和综合评价等原则,自拟中药解热作用的评定标准,对清热药的解热作用进行文献再评价,以确定其可靠性。黄芩、柴胡、青蒿、板蓝根、金银花、连翘作用确切;黄连、半枝莲、地骨皮、忍冬、玄参、石膏、大青叶、牡丹皮、栀子实验依据不足;黄柏无解热作用;知母、苦参、蒲公英、生地黄、赤芍未见相关研究文献。

  12. Re-evaluation of interferences of doubly charged ions of heavy rare earth elements on Sr isotopic analysis using multi-collector inductively coupled plasma mass spectrometry

    International Nuclear Information System (INIS)

    We re-evaluate the interference of doubly charged heavy rare earth elements during Sr isotopic analysis using multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS). A series of mixed solutions of standard reference material SRM 987, rare earth elements, and Sr separated from rock reference materials are measured to assess the influence of isobaric interferences on the MC-ICP-MS analysis of Sr isotopes. After sample dissolution, conventional cation-exchange chromatography is employed for Sr purification of rock reference materials prior to MC-ICP-MS measurement. It has been demonstrated that if the natural abundances of Er and Yb are used to correct for doubly charged ion interferences on Sr, an overcorrection results. In contrast, the use of measured doubly charged ion ratios results in an accurate and precise correction of isobaric interference. This finding is confirmed by analytical results for several certified reference materials from mafic (basaltic) to felsic (granitic) silicate rocks. It is noteworthy that, because Er is more prone to doubly charged ion formation, it dominates over Yb doubly charged ions as an interference source. - Highlights: • We re-investigated interference of doubly charged HREE ion on Sr isotope. • Natural abundance of Er and Yb to correct the interference leads to an overcorrection. • Er is more prone to doubly charged ion formation than Yb

  13. Re-evaluation of the $^{16}$O($n$,$\\gamma$)$^{17}$O cross section at astrophysical energies and its role as neutron poison in the $s$ process

    CERN Document Server

    Mohr, Peter; Pignatari, Marco; Dillmann, Iris; Mengoni, Alberto; Kaeppeler, Franz

    2016-01-01

    The doubly-magic nucleus $^{16}$O has a small neutron capture cross section of just a few tens of microbarn in the astrophysical energy region. Despite of this, $^{16}$O plays an important role as neutron poison in the astrophysical slow neutron capture ($s$) process due to its high abundance. We present in this paper a re-evaluation of the available experimental data for $^{16}$O($n,\\gamma$)$^{17}$O and derive a new recommendation for the Maxwellian-averaged cross sections (MACS) between $kT$= 5$-$100 keV. Our new recommendations are lower up to $kT$= 60 keV compared to the previously recommended values but up to 14\\% higher at $kT$= 100 keV. We explore the impact of this different energy dependence on the weak $s$-process during core helium- ($kT$= 26 keV) and shell carbon burning ($kT$= 90 keV) in massive stars where $^{16}$O is the most abundant isotope.

  14. Quasi-periodic pulsations in solar and stellar flares: re-evaluating their nature in the context of power-law flare Fourier spectra

    CERN Document Server

    Inglis, A R; Dominique, M

    2014-01-01

    The nature of quasi-periodic pulsations in solar and stellar flares remains debated. Recent work has shown that power-law-like Fourier power spectra, also referred to as 'red' noise processes, are an intrinsic property of solar and stellar flare signals, a property that many previous studies of this phenomenon have not accounted for. Hence a re-evaluation of the existing interpretations and assumptions regarding QPP is needed. Here we adopt a Bayesian method for investigating this phenomenon, fully considering the Fourier power law properties of flare signals. Using data from the PROBA2/LYRA, Fermi/GBM, Nobeyama Radioheliograph and Yohkoh/HXT instruments, we study a selection of flares from the literature identified as QPP events. Additionally we examine optical data from a recent stellar flare that appears to exhibit oscillatory properties. We find that, for all but one event tested, an explicit oscillation is not required in order to explain the observations. Instead, the flare signals are adequately descri...

  15. Discovery of Naturally Etched Fission Tracks and Alpha-Recoil Tracks in Submarine Glasses: Reevaluation of a Putative Biosignature for Earth and Mars

    Directory of Open Access Journals (Sweden)

    Jason E. French

    2016-01-01

    Full Text Available Over the last two decades, conspicuously “biogenic-looking” corrosion microtextures have been found to occur globally within volcanic glass of the in situ oceanic crust, ophiolites, and greenstone belts dating back to ~3.5 Ga. These so-called “tubular” and “granular” microtextures are widely interpreted to represent bona fide microbial trace fossils; however, possible nonbiological origins for these complex alteration microtextures have yet to be explored. Here, we reevaluate the origin of these enigmatic microtextures from a strictly nonbiological standpoint, using a case study on submarine glasses from the western North Atlantic Ocean (DSDP 418A. By combining petrographic and SEM observations of corrosion microtextures at the glass-palagonite interface, considerations of the tectonic setting, measurement of U and Th concentrations of fresh basaltic glass by ICP-MS, and theoretical modelling of the present-day distribution of radiation damage in basaltic glass caused by radioactive decay of U and Th, we reinterpret these enigmatic microtextures as the end product of the preferential corrosion/dissolution of radiation damage (alpha-recoil tracks and fission tracks in the glass by seawater, possibly combined with pressure solution etch-tunnelling. Our findings have important implications for geomicrobiology, astrobiological exploration of Mars, and understanding of the long-term breakdown of nuclear waste glass.

  16. Epidermolytic palmoplantar keratoderma of Vörner: re-evaluation of Vörner's original family and identification of a novel keratin 9 mutation.

    Science.gov (United States)

    Küster, Wolfgang; Reis, André; Hennies, Hans Christian

    2002-08-01

    In 1901, Hans Vörner observed a family with a diffuse non-transgredient palmoplantar keratoderma of autosomal dominant inheritance. Histopathologically, he found epidermolytic hyperkeratosis as a characteristic sign and diagnostic criterion of this disorder. We performed a follow-up study of the family originally seen by Vörner in 1901 with clinical, histopathological, and molecular investigations. Clinically, affected family members showed the typical diffuse keratoses over the entire surface of the palms and soles sharply bordered by red margins. A mycotic infection was additionally found in two patients examined. Histopathological investigations confirmed epidermolytic hyperkeratosis. Molecular studies revealed a novel mutation in keratin 9, N160I, in patients from the family. The mutation in the coil-1A domain is thought to have a dominant negative effect on the assembly of keratin intermediate filaments, explaining the dominant inheritance of the phenotype. These findings give further evidence that palmoplantar keratoderma of Vörner represents the same entity as palmoplantar keratoderma of Thost, which was recently re-evaluated in Thost's original family and shown to be caused by a similar mutation, R162 W, in the same segment of keratin 9.

  17. Reevaluation of the linkage of an optic atrophy susceptibility gene to X-chromosomal markers in Finnish families with Leber hereditary optic neuroretinopathy (LHON)

    Energy Technology Data Exchange (ETDEWEB)

    Juvonen, V.; Aula, P.; Vilkki, J.; Nikoskelainen, E.; Savontaus, M.-L.

    1993-07-01

    One of the commonest reasons for sudden-onset optic nerve degeneration in young men can be attributed to maternally inherited Leber hereditary optic neuroretinopathy (LHON) (Nikoskelainen et al. 1987). Specific point mutations at either np 11778 (Wallace et al. 1988) or np 3460 (Howell et al. 1991; Huoponen et al. 1991) in mitochondrial DNA (mtDNA) encoding for respiratory enzyme complex I subunits (i.e., ND4 or ND1) can be found in 70% of families. These mutations exist as being either homoplasmic or heteroplasmic, but the correlation between the degree of heteroplasmy and the risk of developing optic atrophy is far from clear (Holt et al. 1989; Vilkki et al. 1990). Neither does heteroplasmy explain the strong male bias seen in LHON families, when the sex ratio of patients with visual impairment is observed. Earlier results indicated that susceptibility to optic atrophy in Finnish families with LHON was probably determined by an X-chromosomal gene closely linked to DXS7. Contradictory results prompted reevaluation of the existence of an X-chromosomal visual loss susceptibility gene in Finnish LHON families. The results of this present study clearly demonstrate that the earlier close linkage to DXS7 is implausible. The altered Z is due to revised pedigrees, the use of liability classes, and separation of the families according to the associated mtDNA mutation. 16 refs., 1 fig., 1 tab.

  18. Grass carp in the Great Lakes region: establishment potential, expert perceptions, and re-evaluation of experimental evidence of ecological impact

    Science.gov (United States)

    Wittmann, Marion E.; Jerde, Christopher L.; Howeth, Jennifer G.; Maher, Sean P.; Deines, Andrew M.; Jenkins, Jill A.; Whitledge, Gregory W.; Burbank, Sarah B.; Chadderton, William L.; Mahon, Andrew R.; Tyson, Jeffrey T.; Gantz, Crysta A.; Keller, Reuben P.; Drake, John M.; Lodge, David M.

    2014-01-01

    Intentional introductions of nonindigenous fishes are increasing globally. While benefits of these introductions are easily quantified, assessments to understand the negative impacts to ecosystems are often difficult, incomplete, or absent. Grass carp (Ctenopharyngodon idella) was originally introduced to the United States as a biocontrol agent, and recent observations of wild, diploid individuals in the Great Lakes basin have spurred interest in re-evaluating its ecological risk. Here, we evaluate the ecological impact of grass carp using expert opinion and a suite of the most up-to-date analytical tools and data (ploidy assessment, eDNA surveillance, species distribution models (SDMs), and meta-analysis). The perceived ecological impact of grass carp by fisheries experts was variable, ranging from unknown to very high. Wild-caught triploid and diploid individuals occurred in multiple Great Lakes waterways, and eDNA surveillance suggests that grass carp are abundant in a major tributary of Lake Michigan. SDMs predicted suitable grass carp climate occurs in all Great Lakes. Meta-analysis showed that grass carp introductions impact both water quality and biota. Novel findings based on updated ecological impact assessment tools indicate that iterative risk assessment of introduced fishes may be warranted.

  19. Molecular monitoring of African swine fever virus using surveys targeted at adult Ornithodoros ticks : a re-evaluation of Mkuze Game Reserve, South Africa

    Directory of Open Access Journals (Sweden)

    L.F. Arnot

    2009-09-01

    Full Text Available The Mkuze Game Reserve (MGR, in north-eastern KwaZulu-Natal Province, South Africa is an African swine fever virus (ASF controlled area. In a survey conducted in 1978, ASF prevalence in warthogs and Ornithodoros ticks in MGR was determined to be 2 % and 0.06 %, respectively. These values, acknowledged as being unusually low compared to other East and southern African ASF-positive sylvatic-cycle host populations, have not been assessed since. The availability of a sensitive PCR-based virus detection method, developed specifically for the sylvatic tampan host, prompted a re-evaluation of ASF virus (ASFV prevalence in MGR ticks. Of the 98 warthog burrows inspected for Ornithodoros presence, 59 (60.2 % were found to contain tampans and tick sampling was significantly male-biased. Whilst gender sampling-bias is not unusual, the 27 % increase in infestation rate of warthog burrows since the 1978 survey is noteworthy as it anticipates a concomitant increase in ASFV prevalence, particularly in light of the high proportion (75 % of adult ticks sampled. However, despite DNA integrity being confirmed by internal control amplification of the host 16S gene, PCR screening failed to detect ASFV. These results suggest that ASFV has either disappeared from MGR or if present, is localized, occurring at exceptionally low levels. Further extensive surveys are required to establish the ASFV status of sylvatic hosts in this controlled area.

  20. Re-evaluation of the indications for liver transplantation in Wilson's disease based on the outcomes of patients referred to a transplant center.

    Science.gov (United States)

    Ohya, Yuki; Okajima, Hideaki; Honda, Masaki; Hayashida, Shintaro; Suda, Hiroko; Matsumoto, Shiro; Lee, Kwang-Jong; Yamamoto, Hidekazu; Takeichi, Takayuki; Mitsubuchi, Hiroshi; Asonuma, Katsuhiro; Endo, Fumio; Inomata, Yukihiro

    2013-06-01

    The aim of this study was to re-evaluate the indications and timing of LT for WD. From 2000 to 2009, eight patients with WD who had been referred to our institution for LT were enrolled in this study. The mean patient age was 15.9 yr (range, 7-37 yr). Four patients could not receive LT, because there were no available donors. All four patients were treated with chelating agent medication. Three of them (two of two patients with fulminant WD and one of two with cirrhotic WD) who did not undergo LT are still alive and doing well with stable liver functional tests. Only one of the patients with cirrhotic WD who did not undergo LT died of hepatic failure. Even among the four patients who underwent LT, one with fulminant WD recovered from hepatic encephalopathy with apheresis therapy and chelating agent. He later required LT because of severe neutropenia from d-penicillamine. The other three patients who underwent LT recovered and have been doing well. Some of the patients with WD can recover and avoid LT with medical treatment. Even when WD has progressed liver cirrhosis and/or fulminant hepatic failure at the time of diagnosis, medical treatment should be tried before considering LT.

  1. Reevaluation of the hadronic contribution to the muon magnetic anomaly using new $e^{+}e^{-}\\to \\pi^{+}\\pi^{-}$ cross section data from BABAR

    CERN Document Server

    Davier, M; Malaescu, B; Yuan, C Z; Zhang, Z

    2010-01-01

    Using recently published, high-precision pi+pi- cross section data by the BABAR experiment from the analysis of e+e- events with high-energy photon radiation in the initial state, we reevaluate the lowest order hadronic contribution a_mu[had,LO] to the anomalous magnetic moment of the muon. We employ newly developed software featuring improved data interpolation and averaging, more accurate error propagation and systematic validation. With the new data, the discrepancy between the e+e- and tau-based results for the dominant two-pion mode reduces from previously 2.4 sigma to 1.5 sigma in the dispersion integral, though significant local discrepancies in the spectra persist. We obtain for the e+e- based evaluation amu[had,LO] = (695.5 +- 4.1) 10^-10, where the error accounts for all sources. The full Standard Model prediction of a_mu differs from the experimental value by 3.1 sigma.

  2. Reevaluation of the offset of the Great Wall associated with the 1739 M 8.0 Pingluo earthquake, Yinchuan Graben, China (Invited)

    Science.gov (United States)

    Lin, A.; Rao, G.; Hu, J.; Gong, W.

    2013-12-01

    The study of large-magnitude earthquakes that occurred prior to the availability of routine instrumental measurements relies mainly on the analysis of historical documents and field observations. Significant uncertainties often exist in relation to the location of the epicenter, the magnitude, and the actual extent of damage, including the number of fatalities, caused by individual historical earthquakes, because records are generally focused on the effects in the restricted regions that were settled. In these cases, field observations of the geologic effects of large historical and paleo-earthquakes provide direct evidence of the co-seismic ground deformation and macro-seismic intensity of these large-magnitude events, and can therefore help to improve our ability to assess seismic hazards in densely populated epicentral regions. The ruins of ancient civilizations that experienced and were damaged by earthquakes are often used as surface indicators in the study of past seismic events in regions with long historical records, such as China, Japan, and Turkey. China is located in one of the most active seismic regions of the world and has experienced numerous destructive earthquakes over its long history. The damage caused by previous large-magnitude earthquakes has been recorded in historical documents, and co-seismic ground deformation is locally preserved in ruined ancient buildings such as temples, tombs, and other constructions erected over the past several thousand years. Previous studies have shown that the Great Wall of China was damaged and offset by the ca. M 8 Pingluo earthquake of 1739 along an active fault zone in the Yinchuan graben, on the western margin of the Ordos Block in northern central China (e.g., Deng and Liao, 1996, JGR; Zhang et al., 1986, BSSA). In this study, we reevaluate, on the basis of our investigation, the ground deformation caused around the area of the Great Wall by the ca. M 8 Pingluo earthquake of 1739 along an active fault zone

  3. Decadal re-evaluation of contaminant exposure and productivity of ospreys (Pandion haliaetus) nesting in Chesapeake Bay Regions of Concern

    International Nuclear Information System (INIS)

    The last large-scale ecotoxicological study of ospreys (Pandion haliaetus) in Chesapeake Bay was conducted in 2000–2001 and focused on U.S. EPA-designated Regions of Concern (ROCs; Baltimore Harbor/Patapsco, Anacostia/middle Potomac, and Elizabeth Rivers). In 2011–2012, ROCs were re-evaluated to determine spatial and temporal trends in productivity and contaminants. Concentrations of p,p′-DDE were low in eggs and below the threshold associated with eggshell thinning. Eggs from the Anacostia/middle Potomac Rivers had lower total PCB concentrations in 2011 than in 2000; however, concentrations remained unchanged in Baltimore Harbor. Polybrominated diphenyl ether flame retardants declined by 40%, and five alternative brominated flame retardants were detected at low levels. Osprey productivity was adequate to sustain local populations, and there was no relation between productivity and halogenated contaminants. Our findings document continued recovery of the osprey population, declining levels of many persistent halogenated compounds, and modest evidence of genetic damage in nestlings from industrialized regions. - Highlights: • This study documents the continued recovery of the Chesapeake Bay osprey population. • Osprey eggshells have nearly returned to pre-DDT-era thickness. • Organochlorine pesticides are low in eggs, but PCB levels seem unchanged in industrialized areas. • PBDE flame retardants have declined in eggs, but seem to peak near wastewater treatment plants. • There is some evidence of genetic damage in nestling blood samples in the most industrialized areas. - While the Chesapeake Bay osprey population has recovered, concentrations of some persistent contaminants in eggs remain unchanged, and there is some evidence of genetic damage in nestlings

  4. Re-evaluation of kidney histopathology from 13-week toxicity and two-year carcinogenicity studies of melamine in the F344 rat: morphologic evidence of retrograde nephropathy.

    Science.gov (United States)

    Hard, G C; Flake, G P; Sills, R C

    2009-11-01

    The histopathologic changes induced in F344 rat kidney by oral administration of melamine for 13-week and 2-year periods in studies conducted by the National Toxicology Program, NIH,(25) from 1976 to 1983 have been re-evaluated and described in detail. A constellation of tubule changes extending from papilla to cortex consistently included tubule dilatation and tubule basophilia as salient features at the subchronic time point. By 2 years, these lesions had usually resolved into fibrotic scars, in which tubule loss and collagen deposition were prominent, running from superficial cortex into the medulla. These fibrotic lesions required discrimination from chronic scars resulting from infarcts and foci of chronic progressive nephropathy (CPN). A case is presented here for interpreting the constellation of histologic changes induced in rats by melamine as representing an ascending form of nephropathy. The term retrograde nephropathy is considered to be the appropriate nomenclature for both the acute and chronic lesions. The cause for the reflux, emanating from the lower urinary tract, appeared not to be infection as an inflammatory response was not prominent. It can be speculated that melamine precipitation in the lower urinary tract created pressure effects through transient obstruction leading to the renal changes. These changes were different from those involved in a major US outbreak of renal disease and death in cats and dogs associated with triazine-contaminated pet food, in which crystalluria from insoluble melamine/cyanuric acid complexes occurred in the kidney. However, the rat findings may be relevant to melamine-associated kidney disease recently reported in infants in China.

  5. Re-evaluation of Assay Data of Spent Nuclear Fuel obtained at Japan Atomic Energy Research Institute for validation of burnup calculation code systems

    International Nuclear Information System (INIS)

    Highlights: → The specifications required for the analyses of the destructive assay data taken from irradiated fuel in Ohi-1 and Ohi-2 PWRs were documented in this paper. → These data were analyzed using the SWAT2.1 code, and the calculation results showed good agreement with experimental results. → These destructive assay data are suitable for the benchmarking of the burnup calculation code systems. - Abstract: The isotopic composition of spent nuclear fuels is vital data for studies on the nuclear fuel cycle and reactor physics. The Japan Atomic Energy Agency (JAEA) has been active in obtaining such data for pressurized water reactor (PWR) and boiling water reactor (BWR) fuels, and some data has already been published. These data have been registered with the international Spent Fuel Isotopic Composition Database (SFCOMPO) and widely used as international benchmarks for burnup calculation codes and libraries. In this paper, Assay Data of Spent Nuclear Fuel from two fuel assemblies irradiated in the Ohi-1 and Ohi-2 PWRs in Japan are shown. The destructive assay data from Ohi-2 have already been published. However, these data were not suitable for the benchmarking of calculation codes and libraries because several important specifications and data were not included. This paper summarizes the details of destructive assay data and specifications required for analyses of isotopic composition from Ohi-1 and Ohi-2. For precise burnup analyses, the burnup values of destructive assay samples were re-evaluated in this study. These destructive assay data were analyzed using the SWAT2.1 code, and the calculation results showed good agreement with experimental results. This indicates that the quality of destructive assay data from Ohi-1 and Ohi-2 PWRs is high, and that these destructive assay data are suitable for the benchmarking of burnup calculation code systems.

  6. QUASI-PERIODIC PULSATIONS IN SOLAR AND STELLAR FLARES: RE-EVALUATING THEIR NATURE IN THE CONTEXT OF POWER-LAW FLARE FOURIER SPECTRA

    Energy Technology Data Exchange (ETDEWEB)

    Inglis, A. R.; Ireland, J. [Solar Physics Laboratory, Heliophysics Science Division, NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Dominique, M. [Solar-Terrestrial Center of Excellence, Royal Observatory of Belgium, Avenue Circulaire 3, B-1180, Brussels (Belgium)

    2015-01-10

    The nature of quasi-periodic pulsations (QPPs) in solar and stellar flares remains debated. Recent work has shown that power-law-like Fourier power spectra are an intrinsic property of solar and stellar flare signals, a property that many previous studies of this phenomenon have not accounted for. Hence a re-evaluation of the existing interpretations and assumptions regarding QPPs is needed. We adopt a Bayesian method for investigating this phenomenon, fully considering the Fourier power-law properties of flare signals. Using data from the PROBA2/Large Yield Radiometer, Fermi/Gamma-ray Burst Monitor, Nobeyama Radioheliograph, and Yohkoh/HXT instruments, we study a selection of flares from the literature identified as QPP events. Additionally, we examine optical data from a recent stellar flare that appears to exhibit oscillatory properties. We find that, for all but one event tested, an explicit oscillation is not required to explain the observations. Instead, the flare signals are adequately described as a manifestation of a power law in the Fourier power spectrum. However, for the flare of 1998 May 8, strong evidence for an explicit oscillation with P ≈ 14-16 s is found in the 17 GHz radio data and the 13-23 keV Yohkoh/HXT data. We conclude that, most likely, many previously analyzed events in the literature may be similarly described by power laws in the flare Fourier power spectrum, without invoking a narrowband, oscillatory component. Hence the prevalence of oscillatory signatures in solar and stellar flares may be less than previously believed. The physical mechanism behind the appearance of the observed power laws is discussed.

  7. Re-evaluating the reactive uptake of HOBr in the troposphere with implications for the marine boundary layer and volcanic plumes

    Directory of Open Access Journals (Sweden)

    T. J. Roberts

    2014-01-01

    Full Text Available The reactive uptake of HOBr onto halogen-rich aerosols promotes conversion of Br−(aq into gaseous reactive bromine (incl. BrO with impacts on tropospheric oxidants and mercury deposition. However, experimental data quantifying HOBr reactive uptake on tropospheric aerosols is limited, and reported values vary in magnitude. This study re-examines the reaction kinetics of HOBr across a range of aerosol acidity conditions, focusing on chemistry within the marine boundary layer and volcanic plumes. We highlight that the termolecular approach to HOBr reaction kinetics, used in numerical model studies to date, is strictly only valid over a specific pH range. Here we re-evaluate the reaction kinetics of HOBr according to the general acid assisted mechanism. The rate of reaction of HOBr with halide ions becomes independent of pH at high acidity yielding an acid-independent second-order rate constant, kII. The limit of acid-saturation is poorly constrained by available experimental data, although a reported estimate for HOBr+ Br−(aq+H+(aq, is kIIsat = 108–109 M−1 s−1, at pH ≲ 1. By consideration of halide nucleophilic strength and re-evaluation of reported uptake coefficient data on H2SO4-acidified sea-salt aerosol, we suggest the reaction of HOBr(aq + Cl−(aq+H+(aq may saturate to become acid-independent at pH ≤ 6, with kIIsat ~104 M−1 s−1. This rate constant is multiple orders of magnitude lower (a factor of 103 at pH = 3 and a factor of 106 at pH = 0 than that currently assumed in numerical models of tropospheric BrO chemistry, which are based on the termolecular approach. Reactive uptake coefficients, γHOBr, were calculated as a function of composition using the revised HOBr kinetics, with kI = kII · [X−(aq], and X = Br or Cl. γHOBr initially increases with acidity but subsequently declines with increasing H2SO4-acidification of sea-salt aerosol. The HOBr+Cl− uptake coefficient declines due to acid-displacement of HCl

  8. Congenital PCB poisoning: a reevaluation

    Energy Technology Data Exchange (ETDEWEB)

    Miller, R.W.

    1985-05-01

    A review of the literature reveals a need to clarify the pathologic physiology of congenital polychlorinated biphenyl (PCB) poisoning, which is characterized by intrauterine growth retardation, brown staining of the skin and mucous membranes as in Addison's disease, natal teeth, widely open fontanelles and sagittal suture and apparent overgrowth of the gingiva. The skull abnormalities may represent irregular calcification, with natal teeth appearing because the bone of the mandible is penetrated more easily than usual. Some fetuses were poisoned at the time the mothers ingested the oil; others were affected in the subsequent years from residual contamination in the mothers' bodies. The misadventure in Japan was repeated in Taiwan in 1979. The seven congenital cases in Taiwan reported thus far seem to differ from those in Japan. In Taiwan the noses were somewhat black, two of the infants did not have low birth weight and the osseous abnormalities of the skull and gingival hyperplasia were not observed. Systematic followup studies should be made in Taiwan of the children born within 2 years of maternal poisoning with PCBs. Special attention should be given to age at first dentition and skull-X-rays for spotty calcification, among other measures of physical, neurologic and intellectual development.

  9. Congenital PCB poisoning: a reevaluation.

    OpenAIRE

    Miller, R. W.

    1985-01-01

    A review of the literature reveals a need to clarify the pathologic physiology of congenital polychlorinated biphenyl (PCB) poisoning, which is characterized by intrauterine growth retardation, brown staining of the skin and mucous membranes, as in Addison's disease, natal teeth, widely open fontanelles and sagittal suture and apparent overgrowth of the gingiva. The skull abnormalities may represent irregular calcification, with natal teeth appearing because the bone of the mandible is penetr...

  10. Re-evaluation of the significance of penicillin binding protein 3 in the susceptibility of Listeria monocytogenes to β-lactam antibiotics

    Directory of Open Access Journals (Sweden)

    Krawczyk-Balska Agata

    2012-04-01

    Full Text Available Abstract Background Penicillin binding protein 3 (PBP3 of L. monocytogenes has long been thought of as the primary lethal target for β-lactam antibiotics due to the excellent correlation between the MICs of different β-lactams and their affinity for this protein. The gene encoding PBP3 has not yet been directly identified in this gram-positive bacterium, but based on in silico analysis, this protein is likely to be encoded by lmo1438. However, studies examining the effects of mutations in genes encoding known and putative L. monocytogenes PBPs have demonstrated that inactivation of lmo1438 does not affect sensitivity to β-lactams. Results In this study, overexpression of lmo1438 was achieved using an inducible (nisin-controlled expression system. This permitted the direct demonstration that lmo1438 encodes PBP3. PBP3 overexpression was accompanied by slightly elevated PBP4 expression. The recombinant strain overexpressing PBP3 displayed significant growth retardation and greatly reduced cell length in the stationary phase of growth in culture. In antibiotic susceptibility assays, the strain overexpressing PBP3 displayed increased sensitivity to subinhibitory concentrations of several β-lactams and decreased survival in the presence of a lethal dose of penicillin G. However, the MIC values of the tested β-lactams for this recombinant strain were unchanged compared to the parent strain. Conclusions The present study allows a reevaluation of the importance of PBP3 in the susceptibility of L. monocytogenes to β-lactams. It is clear that PBP3 is not the primary lethal target for β-lactams, since neither the absence nor an excess of this protein affect the susceptibility of L. monocytogenes to these antibiotics. The elevated level of PBP4 expression observed in the recombinant strain overexpressing PBP3 demonstrates that the composition of the L. monocytogenes cell wall is subject to tight regulation. The observed changes in the morphology of

  11. Re-evaluation of microscopic and integral cross-section data for important dosimetry reactions. Re-evaluation of the excitation functions for the 24Mg(n,p)24Na, 32S(n,p)32P, 60Ni(n,p)60m+gCo, 63Cu(n,2n)62Cu, 65Cu(n,2n)64Cu, 64Zn(n,p)64Cu, 115In(n,2n)114mIn, 127I(n,2n)126I, 197Au(n,2n)196Au and 199Hg(n,n')199mHg reactions

    International Nuclear Information System (INIS)

    Re-evaluations of cross sections and their associated covariance matrices have been carried out for ten dosimetry reactions: - excitation functions for the 63Cu(n,2n)62Cu, 65Cu(n,2n)64Cu, 64Zn(n,p)64Cu, 115In(n,2n)114mIn and 199Hg(n,n')199mHg reactions were re-evaluated over the neutron energy range from threshold to 20 MeV; - excitation functions for the 24Mg(n,p)24Na, 32S(n,p)32P and 60Ni(n,p)60m+gCo were reevaluated in the energy range from threshold to 21 MeV; - excitation functions for the 127I(n,2n)126I and 197Au(n,2n)196Au reactions were reevaluated in the energy range from threshold to 32 and 40 MeV, respectively. Benchmark calculations performed for 235U thermal fission and 252Cf spontaneous fission neutron spectra show that the integral cross sections derived from the newly evaluated excitation functions exhibit improved agreement with related experimental data when compared with the equivalent data from the IRDF-2002 library. (author)

  12. Statement on two reports published after the closing date of the public consultation of the draft Scientific Opinion on the re-evaluation of aspartame (E 951 as a food additive

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Food Additives and Nutrient Sources added to food (ANS

    2013-12-01

    Full Text Available Following a request from the European Commission, the Panel on Food Additives and Nutrient Sources added to Food (ANS of the European Food Safety Authority (EFSA was asked to deliver a scientific opinion on the re-evaluation of aspartame (E 951 as a food additive. After the end of the public consultation on the draft opinion on the re-evaluation of aspartame (E951 (15th February 2013, the cut-off date for the inclusion of new literature in the assessment, two papers were brought to the attention of EFSA as relevant for the evaluation of aspartame. One was the evaluation by Gift et al. (2013 of several studies carried out by the European Ramazzini Foundation (ERF and the second was the Toxicological Review of Methanol (Noncancer by the US-EPA. The Panel noted that the Gift et al. (2013 review of the ERF studies is consistent with EFSA’s conclusions on the lack of carcinogenic activity of aspartame. The Panel also analysed US-EPA’s Toxicological Review of Methanol (Noncancer in the context of the safety assessment of aspartame. The Panel noted that the combination of the endpoint used, a benchmark dose response (BMR of 5% and the uncertainty factors applied, resulted in a Reference Dose (RfD for exogenous methanol of 2 mg/kg bw/day that was overly conservative. This RfD was by definition in addition to dietary intakes of methanol which were included in the background exposure estimates used by the US EPA. Taking all these factors into consideration, the Panel concluded that the toxicological review of methanol by US-EPA and the review by Gift et al. (2013 do not alter the conclusions on the risk assessment of aspartame performed by EFSA. EFSA confirmed the Acceptable Daily Intake (ADI for aspartame of 40 mg/kg bw/day.

  13. Dosimetry checking of treatment in stereotactic conditions by portal imager; Verification dosimetrique des traitements en conditions stereotaxiques par imageur portal

    Energy Technology Data Exchange (ETDEWEB)

    Santoro, L.; Ailleres, N.; Simeon, S.; Fenoglietto, P. [IRCM, institut de Recherche en Cancerologie, 34 - Montpellier (France)

    2009-10-15

    Objective: The irradiations in stereotactic conditions require specific tools of measurements for the dosimetry software configuration. The spatial resolution of these systems is the crucial point of this modeling and it is always difficult to make this measurement for the edge beams <1.5 cm. The checking of treatment plans is also very important because of the single dose irradiation of the target volume and if the irradiation geometry parameters are checked on the device before the patient installation, it is often difficult for temporal reasons to check and validate the dose distribution in a phantom. A fast validation process of the treatment supply is studied in our institution. Conclusion: A checking of the planned dose distribution can be realised before the patient positioning in the case of treatment in stereotactic conditions. A study realised on less than 3 cm beams is under way. (N.C.)

  14. Automatic image segmentation for treatment planning in radiotherapy; Segmentation automatique des images pour la planifi cation dosimetrique en radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Pasquiera, D. [Centre Galilee, polyclinique de la Louviere, 59 - Lille (France); Peyrodie, L. [Ecole des hautes etudes d' ingenieur, 59 - Lille (France); Laboratoire d' automatique, genie informatique et signal (LAGIS), Cite scientifi que, 59 - Villeneuve d' Ascq (France); Denis, F. [Centre Jean-Bernard, 72 - Le Mans (France); Pointreau, Y.; Bera, G. [Clinique d' oncologie radiotherapie, Centre Henry-S.-Kaplan, CHU Bretonneau, 37 - Tours (France); Lartigau, E. [Departement universitaire de radiotherapie, Centre O. Lambret, Universite Lille 2, 59 - Lille (France)

    2010-07-01

    One drawback of the growth in conformal radiotherapy and image-guided radiotherapy is the increased time needed to define the volumes of interest. This also results in inter- and intra-observer variability. However, developments in computing and image processing have enabled these tasks to be partially or totally automated. This article will provide a detailed description of the main principles of image segmentation in radiotherapy, its applications and the most recent results in a clinical context. (authors)

  15. Re-evaluation of the dose to the cyst wall in P-32 radiocolloid treatments of cystic brain tumors using the Dose-Point-Kernel and Monte Carlo methods

    International Nuclear Information System (INIS)

    Intracavity instillation of β-emitting colloid pharmaceuticals is a common technique used to treat cystic brain tumors. Most of the dosimetric calculations that have been reported in the literature for this problem are based on empirical formulas derived by Loevinger. Concentration of P-32 radiolabeled solution for the delivery of a prescribed dose (200 Gy to the cyst wall) has been published previously using this formalism in what we refer to as a standard nomogram. The calculations using the Loevinger formulas for calculating the P-32 activity necessary to achieve 200 Gy at the cyst wall is re-evaluated and compared to numerically computed results based on full Monte Carlo simulations (EGSnrc) and the dose-point-kernel (DPK) integration method. For cyst diameters greater than 1 cm, the new calculations agree well with previously published results (the standard nomogram) to within a few percents. However, for cyst diameters of less than 1 cm, it is shown that the standard nomogram results underestimate the therapeutic activity by a factor of ∼3 for very small diameters (∼0.2 cm). New tables based on our calculations are presented and the sources of discrepancies are identified. It is concluded that the new set of data based on our calculations should replace the standard nomogram to administer accurately the target dose to the cyst wall for the smaller diameter cysts (<1 cm)

  16. Renal histopathology in toxicity and carcinogenicity studies with tert-butyl alcohol administered in drinking water to F344 rats: a pathology working group review and re-evaluation.

    Science.gov (United States)

    Hard, Gordon C; Bruner, Richard H; Cohen, Samuel M; Pletcher, John M; Regan, Karen S

    2011-04-01

    An independent Pathology Working Group (PWG) re-evaluated the kidney changes in National Toxicology Program (NTP) toxicology/carcinogenicity studies of tert-butyl alcohol (TBA) in F344/N rats to determine possible mode(s) of action underlying renal tubule tumors in male rats at 2-years. In the 13-week study, the PWG confirmed that the normal pattern of round hyaline droplets in proximal convoluted tubules was replaced by angular droplet accumulation, and identified precursors of granular casts in the outer medulla, changes typical of alpha(2u)-globulin (α(2u)-g) nephropathy. In the 2-year study, the PWG confirmed the NTP observation of increased renal tubule tumors in treated male groups. Linear papillary mineralization, another hallmark of the α(2u)-g pathway was present only in treated male rats. Chronic progressive nephropathy (CPN) was exacerbated in high-dose males and females, with a relationship between advanced grades of CPN and renal tumor occurrence. Hyperplasia of the papilla lining was a component of CPN in both sexes, but there was no pelvic urothelial hyperplasia. High-dose females showed no TBA-related nephrotoxicity. The PWG concluded that both α(2u)-g nephropathy and exacerbated CPN modes of action were operative in TBA renal tumorigenicity in male rats, neither of which has relevance for human cancer risk.

  17. A re-evaluation of k0 and related nuclear data for the 555.8 keV gamma-line emitted by the 104mRh-104Rh mother-daughter pair for use in NAA

    International Nuclear Information System (INIS)

    A re-evaluation is made of the k0-factor and related nuclear data for the 555.8 keV gamma-ray of the 104mRh-104Rh mother-daughter pair that are important in neutron activation analysis (NAA). This study considers that the relevant level is also fed by the 4.34 min 104mRh mother (with an absolute gamma-ray emission probability γ2=0.13%) and not only, as assumed in former work, by the 42.3 s 104Rh daughter isotope (with γ3=2.0%). In view of this, generalised equations were developed for both the experimental determination and the analytical use of the k0-factor and of the associated parameters k0(m)/k0(g), Q0(m) and Q0(g) [(m):104mRh; (g): 104Rh], requiring the introduction of the γ2 and γ3 data and also of the 104mRh→104Rh fractional decay factor F2(=0.9987). The experimental determinations were based on irradiations performed in the BR1 reactor in Mol and the WWR-M reactor in Budapest. Furthermore, considering the special formation of the 555.8 keV gamma-ray, the procedure for true-coincidence correction was revised as well. All this led to the compilation and recommendation of a new set of 'k0-NAA' data

  18. Re-evaluation of the 16O(N, γ)17O Cross Section at Astrophysical Energies and Its Role as a Neutron Poison in the s-process

    Science.gov (United States)

    Mohr, Peter; Heinz, Christian; Pignatari, Marco; Dillmann, Iris; Mengoni, Alberto; Käppeler, Franz

    2016-08-01

    The doubly magic nucleus 16O has a small neutron-capture cross section of just a few tens of microbarns in the astrophysical energy region. Despite this, 16O plays an important role as a neutron poison in the astrophysical slow neutron capture (s) process due to its high abundance. We present in this paper a re-evaluation of the available experimental data for 16O(n,γ )17O and derive a new recommendation for the Maxwellian-averaged cross sections between kT = 5 and 100 keV. Our new recommendations are lower up to kT = 60 keV compared to the previously recommended values but up to 14% higher at kT = 100 keV. We explore the impact of this different energy dependence on the weak s-process during core helium burning (kT = 26 keV) and shell carbon burning (kT = 90 keV) in massive stars where 16O is the most abundant isotope.

  19. The Rhetoric of Inferiority of African Slaves in John Fawcett’s Obi; or, Three-Fingered Jack (1800 Re-evaluated in Charlie Haffner’s Amistad Kata-Kata (1987

    Directory of Open Access Journals (Sweden)

    Ulrich Pallua

    2014-02-01

    Full Text Available John Fawcett’s Obi; or, Three-Finger’d Jack (1800 draws a distorted picture of the life of slaves in Jamaica. This paper investigates the ambivalence in this distortion as Fawcett creates two kinds of slaves by pitting them against each other: the loyal and obedient slaves (but still inferior vs. the superstitious-ridden and rebellious slaves deeply rooted in old traditions, thus considered inferior, uneducated, immoral and dangerous. The juxtaposition of what I call ‘anglicised’ slaves instrumentalised by the coloniser and the heathen ‘savages’ that are beyond the reach of the imperial ideology enables Fawcett to substantiate the claim that Christianity successfully promotes slaves to ‘anglicised’ mimic men/women who are then able to carry out its mission: to eradicate the pagan practice of obeah, three-finger’d Jack, and all those slaves that threaten the stability of the coloniser’s superiority. Charlie Haffner’s play Amistad Kata-Kata (1987 is about the heroism of Shengbe Pieh and his fellow slaves on board the La Amistad: on their way to the colonies they revolted, were sent to prison, tried, finally freed, and taken back home after 3 years. The paper shows how Haffner repositions the ‘Amistad trope’ in the 20th century by effacing the materiality of the body of the African slaves, thus re-evaluating the corporeality of the colonised slave in the 19th -century post-abolition debate by coming to terms with the cultural trauma postindependent African collective identity has been experiencing. The re-staging of the play by the ‘Freetong Players’ in 2007/8 commemorated the bicentenary of the abolition of the Atlantic Slave Trade, a unique opportunity to direct the attention to asserting the identity of ‘Post-European’ Africa.

  20. Back to Lifeline: Reevaluate Chen Heqin's “Living Education” Finalism%回归命脉:重审陈鹤琴的“活教育”目的论

    Institute of Scientific and Technical Information of China (English)

    黄书光

    2012-01-01

    当代中国教育学重建的一个重要基点就是要找回活生生的"人","做人"是教育的出发点和归宿。重审陈鹤琴的"活教育"目的论——"做人,做中国人,做现代中国人",体会其中所蕴藏的深刻教育哲理,寻觅其不朽的时代价值与现实意义,求索这一理论形成的实践诉求与本土文化底蕴,感悟其"一切为儿童"的崇高办学理想,对于我们进一步理解当代"教育家办学"和引领中国基础教育改革方向,无疑具有十分重要的启迪之功。%An important basic point of the reconstruction of pedagogy in contemporary China is to retrieve the animated “human being”.“How to behave as a human being” is the start and the destination of education. Reevaluating Chen Heqin's “Living Education” finalism: “behave as a human being, a Chinese, a modem Chinese”; experiencing the profound educational philosophy which contains in it; seeking the eternal time value and practical significance; searching the practical appeal and the local culture undertone which form the theory; comprehending his lofty ideal of running a school that all what we do is for the children; which all undoubtedly provide the fundamental enlightening contribution for us to further understand the idea of “educationists” running schools in contemporary China and guide the basic education reform direction.

  1. A Reevaluation of the Attentional Inertia Concept

    NARCIS (Netherlands)

    W.J.M.I. Verbeke (Willem)

    1992-01-01

    textabstractAnderson's (1983) theory about children's attention behavior during television viewing hypothesizes that attention behavior is affected by positive feedback (the inertia hypothesis) and the degree to which a child understands the television program. During an experiment, neither componen

  2. Reevaluation of air surveillance station siting

    Energy Technology Data Exchange (ETDEWEB)

    Abbott, K. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Jannik, T. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-07-06

    DOE Technical Standard HDBK-1216-2015 (DOE 2015) recommends evaluating air-monitoring station placement using the analytical method developed by Waite (Waite, 1973). The technique utilizes wind rose and population distribution data in order to determine a weighting factor for each directional sector surrounding a nuclear facility. Based on the available resources (number of stations) and a scaling factor, this weighting factor is used to determine the number of stations recommended to be placed in each sector considered. An assessment utilizing this method was performed in 2003 to evaluate the effectiveness of the existing SRS air-monitoring program. The resulting recommended distribution of air-monitoring stations was then compared to that of the existing site perimeter surveillance program (Fledderman 2003). The assessment demonstrated that the distribution of air-monitoring stations at the time generally agreed with the results obtained using the Waite method; however at the time new stations were established in Barnwell and in Williston in order to meet requirements of DOE guidance document EH-0173T.

  3. Reevaluating the Impact of Video Games.

    Science.gov (United States)

    Funk, Jeanne B.

    1993-01-01

    Surveyed 357 seventh and eighth graders about video game play and preference. Found that approximately 64% of boys and 56% of girls played one to two hours of video games per week at home; and that, among five categories of video games, those most preferred by the students were games that involved fantasy violence and sports games. (BC)

  4. Reevaluating the impact of video games.

    Science.gov (United States)

    Funk, J B

    1993-02-01

    The evolution of the video game phenomenon is reviewed and contemporary data are presented. A survey assessing frequency and location of play and game preference was completed by 357 seventh- and eighth-grade students. In this middle-class sample, about two thirds of girls played video games at least one to two hours per week at home, but only 20% played in arcades. About 90% of boys played in the home and about 50% in arcades. Approximately half of preferred games were from one of two categories of violent games, while 2% of preferred games were educational. Parent education about the influence of the media should include recommendations to monitor game playing and influence game selection. PMID:8432085

  5. Reevaluation of the balloon in gastrointestinal manometry.

    Science.gov (United States)

    Wilkes, P R; Hoskin, R W; Semlacher, E A; MacCannell, K L; Tyberg, J V

    1994-09-01

    Although the flow-through catheter (FTC) system has been useful and satisfactorily accurate for gastrointestinal manometry, we hypothesized that a cylindrical, liquid-filled balloon would also accurately reflect stress imposed by a sphincter. Latex balloons were fitted over the side ports of a closed-end catheter. The responses of the balloon and FTC system were compared in a cylindrical chamber commonly identified as a Starling resistor. Independent, constant-pressure sources were used to control both the inwardly directed "contact pressure" of the Starling resistor (Ps) and the intraluminal fluid pressure (P(lum)). The balloon transducers responded linearly and accurately (slope = 1) to changes in both Ps and P(lum) within the test range (0-200 mmHg, 0-26.7 kPa). When either P(lum) or Ps was held constant and the other changed, the balloon transducers always accurately measured the higher of the two pressures. Although the performance of the FTC system was improved after the Starling resistor was lubricated, the FTC system sometimes responded inaccurately to changes in Ps. The ability of the balloon transducers to measure the contractions of the lower esophageal sphincter and of the esophagus was demonstrated. We conclude that the balloon transducer can measure sphincter pressure accurately and suggest that, in certain circumstances, it might be advantageous relative to the FTC system. PMID:7842396

  6. Re-evaluating early breast neoplasia

    OpenAIRE

    Moulis, Sharon; Sgroi, Dennis Charles

    2008-01-01

    Historically, histomorphological and epidemiological data suggested that atypical ductal hyperplasia and ductal carcinoma in situ are the earliest recognizable neoplastic stages of breast cancer progression. Over the past several years, detailed high-throughput molecular genetic, gene expression and epigenetic analyses have enhanced our understanding of these early neoplastic lesions and have re-shaped our view of human breast cancer progression to include multiple distinct pathways of evolut...

  7. A phylogenetic re-evaluation of Arthrinium

    OpenAIRE

    Crous, P.W.; Groenewald, J.Z.

    2013-01-01

    Although the genus Arthrinium (sexual morph Apiospora) is commonly isolated as an endophyte from a range of substrates, and is extremely interesting for the pharmaceutical industry, its molecular phylogeny has never been resolved. Based on morphology and DNA sequence data of the large subunit nuclear ribosomal RNA gene (LSU, 28S) and the internal transcribed spacers (ITS) and 5.8S rRNA gene of the nrDNA operon, the genus Arthrinium is shown to belong to Apiosporaceae in Xylariales. Arthrinium...

  8. A phylogenetic re-evaluation of Arthrinium.

    Science.gov (United States)

    Crous, Pedro W; Groenewald, Johannes Z

    2013-07-01

    Although the genus Arthrinium (sexual morph Apiospora) is commonly isolated as an endophyte from a range of substrates, and is extremely interesting for the pharmaceutical industry, its molecular phylogeny has never been resolved. Based on morphology and DNA sequence data of the large subunit nuclear ribosomal RNA gene (LSU, 28S) and the internal transcribed spacers (ITS) and 5.8S rRNA gene of the nrDNA operon, the genus Arthrinium is shown to belong to Apiosporaceae in Xylariales. Arthrinium is morphologically and phylogenetically circumscribed, and the sexual genus Apiospora treated as synonym on the basis that Arthinium is older, more commonly encountered, and more frequently used in literature. An epitype is designated for Arthrinium pterospermum, and several well-known species are redefined based on their morphology and sequence data of the translation elongation factor 1-alpha (TEF), beta-tubulin (TUB) and internal transcribed spacer (ITS1, 5.8S, ITS2) gene regions. Newly described are A. hydei on Bambusa tuldoides from Hong Kong, A. kogelbergense on dead culms of Restionaceae from South Africa, A. malaysianum on Macaranga hullettii from Malaysia, A. ovatum on Arundinaria hindsii from Hong Kong, A. phragmites on Phragmites australis from Italy, A. pseudospegazzinii on Macaranga hullettii from Malaysia, A. pseudosinense on bamboo from The Netherlands, and A. xenocordella from soil in Zimbabwe. Furthermore, the genera Pteroconium and Cordella are also reduced to synonymy, rejecting spore shape and the presence of setae as characters of generic significance separating them from Arthrinium. PMID:23898419

  9. A phylogenetic re-evaluation of Arthrinium

    NARCIS (Netherlands)

    Crous, P.W.; Groenewald, J.Z.

    2013-01-01

    Although the genus Arthrinium (sexual morph Apiospora) is commonly isolated as an endophyte from a range of substrates, and is extremely interesting for the pharmaceutical industry, its molecular phylogeny has never been resolved. Based on morphology and DNA sequence data of the large subunit nuclea

  10. CHESAPEAKE BAY 2007 RE-EVALUATION

    Science.gov (United States)

    A long term goal of multimedia environmental management is to achieve sustainable ecological resources. Progress towards this goal rests on a foundation of science-based methods and data integrated into predictive multimedia, multi-stressor open architecture modeling systems. The...

  11. How to Reevaluate Outsourcing Contracts Best Practices

    Institute of Scientific and Technical Information of China (English)

    Bill Martorelli

    2011-01-01

    Contract terms for outsourcing continue to change with the times,at least at the margins.The body of contractual best practices changes little in regard to specific terms available for governing outsourcing transactions,but their relative importance can shift in response to both ongoing and emerging risks.In 2009,for example,concerns over Satyam's sudden collapse and terrorism in Mumbai made customers keenly aware of their reliance on key service providers and how fragile they could be.But since then,Satyam is back solidly under new ownership (now Mahindra Satyam),and security measures in India and elsewhere have kept terrorism's specter largely at bay.While the risk of terrorism or a sudden failure of a key supplier-then top of mind - have fallen in priorities,new issues have emerged as more likely near-term concerns.%In order to effectively address contractual protections for threats existing in today's environment Forrester urges sourcing professionals to consider variations on time-honored outsourcing contractual best practices.

  12. Dementia and functional cerebral imaging a reevaluation

    International Nuclear Information System (INIS)

    New concepts which concerned especially the nosologic classification of dementia as for example Dementia with Lewy Bodies (DLB) incite to revalue the main characteristics of the regional cerebral blood flow measurements studied by SPECT in several forms of dementia. SPECT analysis with 99m-Technetium HMPAO (555 MBq) was performed to 20 patients with probable DLB, 20 patients with probable Alzheimer's disease (AD) and 20 patients with Fronto-Temporal dementia (FTD). Ten pairs of regions of interest were analysed. Tracer uptake was expressed as a cortico-cerebellar activity ratio. Statistical analysis of index of fixation was performed using an univariate analysis of variance, and a selection of significative ROIs was performed using two cut-off values (80 and 82.5 %). In the FTD group, a decrease of HMPAO uptake in frontal cortical regions of interest (internal, lateral and posterior) was observed. In the DLB group the decrease of HMPAO uptake was widespread and concerned all the cortical regions of interest except the posterior frontal and occipital regions. Finally in the AD group there was a limited temporal and parietal hypoperfusion more marked on the left side without frontal hypoperfusion. This last result was obtained whatever the cognitive impairment. Consequently it seems that the frontal hypoperfusion previously reported in AD groups was induced by the fact that patients with DLB were also included because the diagnosis was not established. In conclusion we estimate that SPECT studies could be used more often in clinical research especially for a classification approach of dementia. (authors)

  13. BOARD-INVITED REVIEW: Efficiency of converting digestible energy to metabolizable energy and reevaluation of the California Net Energy System maintenance requirements and equations for predicting dietary net energy values for beef cattle.

    Science.gov (United States)

    Galyean, M L; Cole, N A; Tedeschi, L O; Branine, M E

    2016-04-01

    For the past several decades, nutrient requirement systems for beef cattle in North America have recommended that dietary ME can be calculated as dietary DE × 0.82, but considerable published data suggest a variable relationship between DE and ME. We reviewed the literature and tabulated the results of 23 respiration calorimetry studies (87 treatment mean data points), in which measurements of fecal, urinary, and gaseous energy were determined with beef cattle (bulls, steers, and heifers) and growing dairy cattle. Mixed-model regression analyses to adjust for the effects of the citation from which the data were obtained suggested a strong linear relationship between ME and DE (Mcal/kg of DM; ME = 0.9611 × DE - 0.2999; = 0.986, root mean square error [RMSE] = 0.048, linear regression equation indicated high correlations of residuals with other dietary components, and a slight increase in precision was obtained when dietary CP, ether extract, and starch (% of DM) concentrations were included in a multiple linear regression equation (citation-adjusted = 0.992, RMSE = 0.039). Using the simple linear relationship, we reevaluated the original data used to develop the California Net Energy System (CNES) for beef cattle by recalculating ME intake and heat production and regressing the logarithm of heat production on ME intake (both per BW, kg daily). The resulting intercept and slope of the recalculated data did not differ ( ≥ 0.34) from those reported for the original analyses of the CNES data, suggesting that use of the linear equation for calculating ME concentration was consistent with NEm and NEg values as derived in the CNES. Nonetheless, because the cubic equations recommended by the NRC to calculate dietary NEm and NEg from ME were based on conversion of DE to ME using 0.82, these equations were mathematically recalculated to account for the linear relationship between DE and ME. Overall, our review and analyses suggested that there is a strong linear

  14. Re-evaluation of Vernacular Architecture Research Paradigm:From Feature Oriented to Problem Oriented%乡土建筑研究范式的再定位:从特色导向到问题导向

    Institute of Scientific and Technical Information of China (English)

    吴志宏

    2014-01-01

    本文深入分析了乡土建筑研究中以“特色为导向”研究范式存在的问题,认为它是近代中国文化认同的危机而形成的“中国特色”建筑话语的延续。在当下现代文化转型基本完成的语境下,“特色导向”的研究范式不再具有天然的合理性。乡土建筑研究应该回归乡土,研究乡土中现实的条件和问题,即所谓“问题导向”的研究范式。乡土研究应该更加关注那些日常的、大量性的、“无特色”的普通当代民居,注重对其形态生成机制和演化规律的研究。最后为乡土建筑研究提出一些新的研究可能。%This paper attempts to re-evaluate the feature-oriented research paradigm of vernacular architecture, which is regarded as the architectural discourse with the “Chinese identity” created by Chinese cultural crisis of western invasion from 19 century. When Chinese modern cultural transformation had already completed recently, however, the feature-oriented paradigm has also lost its rationality along with its professional attention. Thus, vernacular architecture research paradigm should be transformed from feature oriented to problem oriented, attach importance to the true reality and issues in rural areas, pay more attention to the ordinary, extensive, and nondescript folk houses, and focus on the basic mechanism and law of morphological evolution of the vernacular architecture. Finally, it’s expected that it will provide references for future studies.

  15. 强化农药监测与再评价,科学防控各类安全风险%Strengthen the Monitoring of Pesticide and Re-evaluation of Scientific Prevention and Control of All Kinds of Security Risks

    Institute of Scientific and Technical Information of China (English)

    宗伏霖; 顾宝根; 嵇莉莉; 朴秀英; 吕宁

    2013-01-01

    This paper mainly elaborates the necessity and feasibility of establishing the pesticide safety monitoring,implementing pesticide re-evaluation and re-registration after their registered in china.Establishing the policy of pesticide re-evaluation and re-registration by following and learning from international pesticide management mode are the perfection of Chinese pesticide management policy,and are inevitable for pesticide safety management in the new period.%本文主要阐述在我国建立登记后农药安全性监测,实施农药再评价、再登记管理的必要性、可行性.遵循、借鉴国际农药管理模式,建立我国的农药再评价、再登记制度是对我国农药管理制度的完善,是新时期农药安全管理的必然.

  16. Seismic re-evaluation of Mochovce nuclear power plant. Seismic reevaluation of civil structures

    International Nuclear Information System (INIS)

    In this contribution, an overview of seismic design procedures used for reassessment of seismic safety of civil structures at the Mochovce NPP in Slovak Republic presented. As an introduction, the objectives, history, and current status of seismic design of the NPP have been explained. General philosophy of design methods, seismic classification of buildings, seismic data, calculation methods, assumptions on structural behavior under seismic loading and reliability assessment were described in detail in the subsequent section. Examples of calculation models used for dynamic calculations of seismic response are given in the last section. (author)

  17. Radioecological and dosimetric consequences of the Chernobyl accident in France; Consequences radioecologiques et dosimetriques de l'accident de Tchernobyl en France

    Energy Technology Data Exchange (ETDEWEB)

    Renaud, Ph.; Beaugelin, K.; Maubert, H.; Ledenvic, Ph. [Inst. de Protection et de Surete Nucleaire, CEA Centre d' Etudes de Fontenay-aux-Roses, 92 (France)

    1997-11-01

    This study has as objective a survey of the radioecological and dosimetric consequences of the Chernobyl accident in France, as well as a prognosis for the years to come. It was requested by the Direction of Nuclear Installation Safety (DSIN) in relation to different organisms which effected measurements after this accident. It is based on the use of combined results of measurements and modelling by means of the code ASTRAL developed at IPSN. Various measurements obtained from five authorities and institutions, were made available, such as: activity of air and water, soil, processed food, agricultural and natural products. However, to achieve the survey still a modelling is needed. ASTRAL is a code for evaluating the ecological consequences of an accident. It allows establishing the correspondence between the soil Remnant Surface Activities (RSA, in Bq.m{sup -2}), the activity concentration of the agricultural production and the individual and collective doses resulting from external and internal exposures (due to inhalation and ingestion of contaminated nurture). The results of principal synthesis documents on the Chernobyl accident and its consequences were also used. The report is structured in nine sections, as follows: 1.Introduction; 2.Objective and methodology; 3.Characterization of radioactive depositions; 4;Remnant surface activities; 5.Contamination of agricultural products and foods; 6.Contamination of natural, semi-natural products and of drinking water; 7.Dosimetric evaluations; 8.Proposals for the environmental surveillance; 9.Conclusion. Finally, after ten years, one concludes that at presentthe dosimetric consequences of the Chernobyl accident in France were rather limited. For the period 1986-2046 the average individual effective dose estimated for the most struck zone is lower than 1500 {mu}Sv, which represents almost 1% of the average natural exposure for the same period. At present, the cesium 137 levels are at often inferior to those recorded before the accident.

  18. Radioecological and dosimetric consequences of Chernobyl accident in France; Consequences radioecologiques et dosimetriques de l`accident de Tchernobyl en France

    Energy Technology Data Exchange (ETDEWEB)

    Renaud, Ph.; Beaugelin, K.; Maubert, H.; Ledenvic, Ph

    1997-12-31

    After ten years and the taking in account of numerous data, it can be affirmed that the dosimetric consequences of Chernobyl accident will have been limited in France. for the period 1986-2046, the individual middle efficient dose commitment, for the area the most reached by depositing is inferior to 1500 {mu}Sv, that represents about 1% of middle natural exposure in the same time. but mountains and forests can have more important surface activities than in plain. Everywhere else, it can be considered that the effects of Chernobyl accident are disappearing. the levels of cesium 137 are now often inferior to what they were before the accident. (N.C.)

  19. Dosimetric and health consequences of radon ingestion via drinking water; Consequences dosimetriques et sanitaires de l'ingestion de radon via l'eau de boisson

    Energy Technology Data Exchange (ETDEWEB)

    Laurent, O.; Guseva canu, I. [IRSN, Laboratoire d' epidemiologie, DRPH/SRBE/LEPID, 92 - Fontenay-aux-Roses (France); Blanchardon, E. [IRSN, Laboratoire d' evaluation de la dose interne, DRPH/SDI/LEDI, 92 - Fontenay-aux-Roses (France)

    2010-10-15

    Lung cancer risk following radon inhalation is strongly established. On the contrary, much less is known about the possible health effects of radon ingestion via drinking water. This article summarizes the current knowledge of dosimetry following radon ingestion. Results from epidemiological studies of radon in drinking water are also presented and discussed. (author)

  20. Neutron capture therapy of ocular melanoma: dosimetry and microdosimetry approaches; Therapie par capture de neutrons des melanomes oculaires: approches dosimetrique et microdosimetrique

    Energy Technology Data Exchange (ETDEWEB)

    Pignol, J.P.; Methlin, G. [Centre Paul Strauss, 67 - Strasbourg (France); Abbe, J.C. [Strasbourg-1 Univ., 67 (France). Centre de Recherches Nucleaires; Stampfler, A. [Strasbourg-1 Univ., 67 (France); Lefebvre, O. [Faculte de Medecine, 67 - Strasbourg (France); Sahel, J. [Centre Hospitalier Universitaire, 67 - Strasbourg (France)

    1994-06-01

    Neutron capture therapy (NCT) aims at destroying cancerous cells with the {alpha} and {sup 7}Li particles produced by the neutron capture reaction on {sup 10}B. This note reports on the study of the boron distribution in tissues on an animal model (nude mice) xenografted with a human ocular melanoma after an i.p.injection of 2g/kg of {sup 10}B-BPA and in cells cultured in the presence of 530 {mu}mol/l of {sup 10}B-BPA. A concentration of 64 ppm of {sup 10}B in the active part of the tumour with a ratio of concentrations versus the skin of 3.7 are observed. Investigations on cells reveal the presence of boron in the cytoplasm. The biological, dosimetric and microdosimetric consequences of these findings are discussed. (authors). 15 refs., 2 tabs., 2 figs.

  1. The fallout in France of the Chernobyl accident. Radioecological and dosimetric consequences; Les retombees en France de l'accident de Tchernobyl. Consequences radioecologiques et dosimetriques

    Energy Technology Data Exchange (ETDEWEB)

    Renaud, Ph.; Beaugelin, K.; Maubert, H.; Ledenvic, Ph. [CEA Fontenay-aux-Roses, 92 (France). Inst. de Protection et de Surete Nucleaire

    1999-07-01

    For the first time, the whole of scientific data available has been gathered and exploited thanks to the ASTRAL model, developed at the Institute of protection and nuclear safety, (IPSN). This model has allowed to explain the principal causes of land and food contamination, as well their potential consequences on the human being. This book has elaborated with the help of every organism that has made radioactivity measurements in environment and man and his feeding. The extent of information sources used in this work makes of it a reference work. It allows to estimate the impact, in France of the Chernobyl accident on each of us and to understand the transfer mechanisms of radioactivity in environment. (N.C.)

  2. Techniques and results of extremities dosimetric assessments among interventional imagery operators; Techniques et resultats d'evaluations dosimetriques des extremites chez les operateurs en imagerie interventionnelle

    Energy Technology Data Exchange (ETDEWEB)

    Donadille, L.; Tagnard-Merat, F.; Rehel, J.L. [Institut de Radioprotection et de Surete Nucleaire, 92 - Fontenay aux Roses (France); Gauron, C. [Institut national de recherche et de securite pour la prevention des accidents du travail et des maladies professionnelles (INRS), Centre de Paris, 30 rue Olivier Noyer, 75680 Paris Cedex 1 4 (France)

    2009-07-01

    The authors evoke different surveys made among interventional imagery operators to assess the doses received by their hands. The operators had a local dosimeter on their middle finger nail during a single procedure, and had then to fill in a questionnaire. At least ten measurements per operator are required for the survey. The survey started in 2008 and is planned to end in December 2009. Some results are already briefly discussed

  3. Is there a future for dosimetry by portal imaging?; Le controle dosimetrique par imagerie portale a-t-il un avenir?

    Energy Technology Data Exchange (ETDEWEB)

    Huyskens, D.P. [Hopital Universitairel Gasthuisberg, Dept. de Radiotherapie, Louvain (Belgium)

    2000-12-01

    This article deals with the potential benefits of portal imaging as a tool for the dosimetric control of a radiotherapy treatment. In the introduction the advantages of dosimetric control with portal imaging are described. Subsequently, the physical problem is considered between patient exit dose and dose at the level of the portal detector. Measurements with phantoms have shown that this relationship is complex: different algorithms have been developed by groups of researchers and some of them are summarised in this article. Finally, three examples of dosimetric control using portal imaging are presented: in vivo dosimetry on the beam axis, dosimetric profiles in two dimensions and portal dosimetry for intensity modulation. (author)

  4. 中药上市后再评价HIS“真实世界”集成数据仓库的构建与实现%Construction and realization of real world integrated data warehouse from HIS on re-evaluation of post-maketing traditional Chinese medicine

    Institute of Scientific and Technical Information of China (English)

    庄严; 谢邦铁; 翁盛鑫; 谢雁鸣

    2011-01-01

    Objective: To construct real world integrated data warehouse on re-evaluation of post-marketing traditional Chinese medicine for the research on key techniques of clinic re-evaluation which mainly includes indication of traditional Chinese medicine, dosage usage, course of treatment, unit medication, combined disease and adverse reaction, which provides data for reviewed research on its safety,availability and economy,and provides foundation for perspective research. Method: The integrated data warehouse extracts and integrate data from HIS by information collection system and data warehouse technique and forms standard structure and data. The further research is on process based on the data. Result: A data warehouse and several sub data warehouses were built,which focused on patients' main records , doctor orders, diseases diagnoses, laboratory results and economic indications in hospital. Conclusion:These data warehouses can provide research data for re-evaluation of post-marketing traditional Chinese medicine, and it has clinical value. Besides, it points out the direction for further research.%目的:构建中药上市后再评价HIS(hospital information system)集成数据仓库,为以中药适应症、剂量疗程、联合用药、合并疾病以及不良反应等为主要内容的中药上市后临床再评价关键技术研究提供数据支撑,为上市后中成药的安全性、有效性和经济性的回顾研究提供数据,同时也为前瞻性研究提供基础.方法:上市中药HIS集成数据仓库利用信息采集系统和数据仓库技术,将多家医院HIS系统的数据进行清洗和有机整合,形成结构标准化、数据规范化的统一的数据仓库,在此基础上开展上市中药再评价关键技术研究.结果:构建了围绕患者住院主记录、患者住院医嘱、患者疾病诊断以及检验指标和经济指标几个主题的包含海量数据的数据仓库和多个可供研究的子数据仓库.结论:建立的数

  5. Designs and thoughts of real world integrated data warehouse from HIS on re-evaluation of post-maketing traditional Chinese medicine%中药上市后再评价HIS“真实世界”集成数据仓库的设计方法探讨

    Institute of Scientific and Technical Information of China (English)

    庄严; 谢邦铁; 翁盛鑫; 谢雁鸣

    2011-01-01

    目的:探讨利用医院信息系统数据的集成构建涵盖广泛的用于药物上市后再评价的大型数据库系统的可行性和必要性,为中药上市后再评价HIS(hospital information system)集成数据仓库的构建提供总体设计思路和方法.方法:通过对国内外利用电子信息系统开展基于真实世界的临床试验设计的分析和对比,结合我国医院信息系统的特性,从设计思路、设计特点、存在问题和解决办法等几个方面对总体构架进行设计和探讨.结果:提出了中药上市后再评价HIS集成数据仓库的设计方案,指明了建设的途径和方法.结论:提出的中药上市后再评价HIS集成数据仓库的设计方案具有高内聚低耦合、安全、通用、高效、可维护性好的特点,可以有效解决多家医院HIS数据集成过程中的问题和挑战,具有实用价值.%Objective: To discuss the feasibility and necessity of using HIS data integration to build large data warehouse system which is extensively used on re-evaluation of post-marketing traditional Chinese medicine, and to provide the thought and method of the overall design for it. Method: With domestic and overseas'analysis and comparison on clinical experiments'design based on real world using electronic information system, and with characteristics of HIS in China, a general framework was designed and discussed which refers to design thought, design characteristics, existing problems and solutions and so on. Result: A design scheme of HIS data warehouse on re-evaluation of post-marketing traditional Chinese medicine was presented. Conclusion: The design scheme was proved to be high coherence and low coupling, safe, Universal, efficient and easy to maintain, which can effectively solve the problems many hospitals have faced during the process of HIS data integration.

  6. A re-evaluation of k sub 0 and related nuclear data for the 555.8 keV gamma-line emitted by the sup 1 sup 0 sup 4 sup m Rh- sup 1 sup 0 sup 4 Rh mother-daughter pair for use in NAA

    CERN Document Server

    Corte, F D; Simonits, A; Bossus, D; Sluijs, R V; Pommé, S

    1999-01-01

    A re-evaluation is made of the k sub 0 -factor and related nuclear data for the 555.8 keV gamma-ray of the sup 1 sup 0 sup 4 sup m Rh- sup 1 sup 0 sup 4 Rh mother-daughter pair that are important in neutron activation analysis (NAA). This study considers that the relevant level is also fed by the 4.34 min sup 1 sup 0 sup 4 sup m Rh mother (with an absolute gamma-ray emission probability gamma sub 2 =0.13%) and not only, as assumed in former work, by the 42.3 s sup 1 sup 0 sup 4 Rh daughter isotope (with gamma sub 3 =2.0%). In view of this, generalised equations were developed for both the experimental determination and the analytical use of the k sub 0 -factor and of the associated parameters k sub 0 (m)/k sub 0 (g), Q sub 0 (m) and Q sub 0 (g) [(m): sup 1 sup 0 sup 4 sup m Rh; (g): sup 1 sup 0 sup 4 Rh], requiring the introduction of the gamma sub 2 and gamma sub 3 data and also of the sup 1 sup 0 sup 4 sup m Rh-> sup 1 sup 0 sup 4 Rh fractional decay factor F sub 2 (=0.9987). The experimental determinations...

  7. Practice of Post-marketing Safety Reevaluation of Salvianolate and Other TCM Injections in Our Hospital%我院开展丹参多酚酸盐等中药注射剂上市后安全性再评价的实践Δ

    Institute of Scientific and Technical Information of China (English)

    吕世文; 郭佳奕; 朱亚兰

    2015-01-01

    OBJECTIVE:To explore the idea and method of post-marketing safety reevaluation of TCM injection in our hospi-tal. METHODS:In case-control study,salvianolate for injection was chosen for practice. 1 000 patients with stable angina receiv-ing Salvianolate for injection in our hospital during May 2012-Oct. 2013 were selected as subjects. The occurrence of ADR/ADE were observed and Logistic regression analysis was conducted by using SPSS 20.0 software. RESULTS:The incidence of ADR/ADE was 0.6%,and rare(0.1%-1%). The ADR/ADE were general and mainly manifested as erythra(66.67%). Skin and its ap-pendants were main organs involved in ADR(66.67%). Logistic regression analysis showed that gender,drug combination and age are risk factors of ADR/ADE. CONCLUSIONS:The post-marketing safety reevaluation of TCM injection not only make up for the deficiency of pre-marketing safety evaluation of TCM injection and find out potential delayed and severe ADR/ADE and drug inter-action,but also provide reference for rational drug use in the clinic and guarantee the safe and rational drug use.%目的:探索我院开展中药注射剂上市后安全性再评价的研究思路与方法。方法:采用队列内病例-对照研究,以注射用丹参多酚酸盐为例进行实践。选取我院2012年5月至2013年10月1000例使用注射用丹参多酚酸盐的冠心病稳定性心绞痛患者为研究对列,观察其不良反应/不良事件(ADR/ADE)的发生情况,结果采用SPSS 20.0软件进行Logistic回归分析。结果:患者的ADR/ADE发生率为0.6%,均为偶见(0.1%~1%),级别为“一般”,主要表现为皮疹(66.67%),主要累及器官为皮肤及其附件(66.67%);经Logistic回归分析显示,性别、合并用药、年龄是ADR/ADE发生的危险因素。结论:对中药注射剂进行上市后安全性再评价,不仅弥补了中药注射剂在药品上市前评价的不足,发现可能存

  8. Reevaluation of Turkey's hydropower potential and electric energy demand

    International Nuclear Information System (INIS)

    This paper deals with Turkey's hydropower potential and its long-term electric energy demand predictions. In the paper, at first, Turkey's energy sources are briefly reviewed. Then, hydropower potential is analyzed and it has been concluded that Turkey's annual economically feasible hydropower potential is about 188 TWh, nearly 47% greater than the previous estimation figures of 128 TWh. A review on previous prediction models for Turkey's long-term electric energy demand is presented. In order to predict the future demand, new increment ratio scenarios, which depend on both observed data and future predictions of population, energy consumption per capita and total energy consumption, are developed. The results of 11 prediction models are compared and analyzed. It is concluded that Turkey's annual electric energy demand predictions in 2010, 2015 and 2020 vary between 222 and 242 (average 233) TWh; 302 and 356 (average 334) TWh; and 440 and 514 (average 476) TWh, respectively. A discussion on the role of hydropower in meeting long-term demand is also included in the paper and it has been predicted that hydropower can meet 25-35% of Turkey's electric energy demand in 2020

  9. Re-telling, Re-evaluating and Re-constructing

    Directory of Open Access Journals (Sweden)

    Gorana Tolja

    2013-11-01

    Full Text Available 'Graphic History: Essays on Graphic Novels and/as History '(2012 is a collection of 14 unique essays, edited by scholar Richard Iadonisi, that explores a variety of complex issues within the graphic novel medium as a means of historical narration. The essays address the issues of accuracy of re-counting history, history as re-constructed, and the ethics surrounding historical narration.

  10. Reevaluating the Serotype II Capsular Locus of Streptococcus agalactiae▿

    OpenAIRE

    Martins, E. R.; Melo-Cristino, J.; Ramirez, M.

    2007-01-01

    We report a novel sequence of the serotype II capsular locus of group B streptococcus that resolves inconsistencies among the results of various groups and the sequence in GenBank. This locus was found in diverse lineages and presents genes consistent with the complete synthesis of the type II polysaccharide.

  11. Reevaluation of mid-Pliocene North Atlantic sea surface temperatures

    Science.gov (United States)

    Robinson, Marci M.; Dowsett, Harry J.; Dwyer, Gary S.; Lawrence, Kira T.

    2008-01-01

    Multiproxy temperature estimation requires careful attention to biological, chemical, physical, temporal, and calibration differences of each proxy and paleothermometry method. We evaluated mid-Pliocene sea surface temperature (SST) estimates from multiple proxies at Deep Sea Drilling Project Holes 552A, 609B, 607, and 606, transecting the North Atlantic Drift. SST estimates derived from faunal assemblages, foraminifer Mg/Ca, and alkenone unsaturation indices showed strong agreement at Holes 552A, 607, and 606 once differences in calibration, depth, and seasonality were addressed. Abundant extinct species and/or an unrecognized productivity signal in the faunal assemblage at Hole 609B resulted in exaggerated faunal-based SST estimates but did not affect alkenone-derived or Mg/Ca–derived estimates. Multiproxy mid-Pliocene North Atlantic SST estimates corroborate previous studies documenting high-latitude mid-Pliocene warmth and refine previous faunal-based estimates affected by environmental factors other than temperature. Multiproxy investigations will aid SST estimation in high-latitude areas sensitive to climate change and currently underrepresented in SST reconstructions.

  12. A reevaluation of the absenteeism-job satisfaction relationship.

    Science.gov (United States)

    Hackett, R D; Guion, R M

    1985-06-01

    Previous reviews of the relationship of employee absenteeism to job satisfaction have largely neglected the size of the relationships reported and the artifacts that can affect statistical tests of significance. This paper applies the F. L. Schmidt-J. E. Hunter (1977, Journal of Applied Psychology, 62, 529-540) model of validity generalization in assessing the nature and strength of the relationship of absence to attitudes. Issues concerning the reliability and validity of absence measures are addressed, correlations between absence and job satisfaction are compiled and summarized, and an agenda for future research is set out. Considering the reliability estimates reported for the Frequency, Attitudinal, and Time Lost indices, the Time Lost Index was found to be the most reliable (r xx = .66, SD = .28). Factor analyses of intercorrelations among absence measures provided tentative support for a voluntary-involuntary absenteeism distinction. Combining all measures of satisfaction and all measures of absences, the mean correlation between absence and attitudes is -.09 (SD = .13). In addition to more comprehensive theory-guided multivariate research, future studies should aim toward a reconceptualization of absenteeism as a construct to take into consideration the perceptions of the workers themselves. PMID:10300152

  13. Risk in Enterprise Cloud Computing: Re-Evaluated

    Science.gov (United States)

    Funmilayo, Bolonduro, R.

    2016-01-01

    A quantitative study was conducted to get the perspectives of IT experts about risks in enterprise cloud computing. In businesses, these IT experts are often not in positions to prioritize business needs. The business experts commonly known as business managers mostly determine an organization's business needs. Even if an IT expert classified a…

  14. Re-evaluation of hyaluronidase in peribulbar anaesthesia.

    OpenAIRE

    Prosser, D P; Rodney, G E; Mian, T; Jones, H. M.; Khan, M Y

    1996-01-01

    AIMS/BACKGROUND: Hyaluronidase can augment the actions of local anaesthetics in peribulbar anaesthesia. However, evidence suggests satisfactory anaesthesia can be achieved using mixtures without hyaluronidase. A randomised double blind study was conducted on 50 patients, undergoing peribulbar anaesthesia, to validate this observation. METHODS: Patients received a standard mixture of local anaesthetic (0.5% bupivacaine and 2% lignocaine in a 1:1 ratio) with or without hyaluronidase (25 IU/ml o...

  15. Market orientation – a pertinent solution in reevaluating traditional marketing

    Directory of Open Access Journals (Sweden)

    Luminita Zait

    2010-12-01

    Full Text Available This article focuses on describing the latest trends in the theoretical and practical development of the marketing concept. Market orientation is the main item discussed, emphasizing the advantages and pitfalls of applying such a specific concept.

  16. Special Education: Evaluation and Reevaluation. Alliance Action Information Sheets

    Science.gov (United States)

    Technical Assistance ALLIANCE for Parent Centers, 2007

    2007-01-01

    Before a child receives special education or related services, he or she must have an evaluation. The evaluation will help determine if a child needs special education. A parent or a member of the school staff may make the request for an evaluation. The child's parent must give consent in writing for the first evaluation. The evaluation will…

  17. Reevaluation of the value of autoparasitoids in biological control.

    Directory of Open Access Journals (Sweden)

    Lian-Sheng Zang

    Full Text Available Autoparasitoids with the capacity of consuming primary parasitoids that share the same hosts to produce males are analogous to intraguild predators. The use of autoparasitoids in biological control programs is a controversial matter because there is little evidence to support the view that autoparasitoids do not disrupt and at times may promote suppression of insect pests in combination with primary parasitoids. We found that Encarsia sophia, a facultative autoparasitoid, preferred to use heterospecific hosts as secondary hosts for producing males. The autoparasitoids mated with males originated from heterospecifics may parasitize more hosts than those mated with males from conspecifics. Provided with an adequate number of males, the autoparasitoids killed more hosts than En. formosa, a commonly used parasitoid for biological control of whiteflies. This study supports the view that autoparasitoids in combination with primary parasitoids do not disrupt pest management and may enhance such programs. The demonstrated preference of an autoparasitoid for heterospecifics and improved performance of males from heterospecifics observed in this study suggests these criteria should be considered in strategies that endeavor to mass-produce and utilize autoparasitoids in the future.

  18. Re-evaluation of the immunological Big Bang.

    Science.gov (United States)

    Flajnik, Martin F

    2014-11-01

    Classically the immunological 'Big Bang' of adaptive immunity was believed to have resulted from the insertion of a transposon into an immunoglobulin superfamily gene member, initiating antigen receptor gene rearrangement via the RAG recombinase in an ancestor of jawed vertebrates. However, the discovery of a second, convergent adaptive immune system in jawless fish, focused on the so-called variable lymphocyte receptors (VLRs), was arguably the most exciting finding of the past decade in immunology and has drastically changed the view of immune origins. The recent report of a new lymphocyte lineage in lampreys, defined by the antigen receptor VLRC, suggests that there were three lymphocyte lineages in the common ancestor of jawless and jawed vertebrates that co-opted different antigen receptor supertypes. The transcriptional control of these lineages during development is predicted to be remarkably similar in both the jawless (agnathan) and jawed (gnathostome) vertebrates, suggesting that an early 'division of labor' among lymphocytes was a driving force in the emergence of adaptive immunity. The recent cartilaginous fish genome project suggests that most effector cytokines and chemokines were also present in these fish, and further studies of the lamprey and hagfish genomes will determine just how explosive the Big Bang actually was. PMID:25517375

  19. Cordaiteans in paleotropical wetlands: An ecological re-evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Raymond, Anne [Dept. of Geology and Geophysics, Texas A and M University, College Station, TX 77843-3115 (United States); Ecology and Evolutionary Biology, Texas A and M University, College Station, TX 77843-3115 (United States); Lambert, Lance [Dept. of Geological Sciences, University of Texas at San Antonio, San Antonio, TX 78249 (United States); Costanza, Suzanne [Paleobotanical Museum, Harvard University, Cambridge, MA 02138 (United States); Slone, E.J. [Dept. of Geology and Geophysics, Texas A and M University, College Station, TX 77843-3115 (United States); Cutlip, P.C. [Dept. of Natural Science, St. Petersburg College, St. Petersburg, FL 33733-3489 (United States)

    2010-08-01

    Cordaiteans in cordaite-dominated permineralized peat from Pennsylvanian coals in Iowa have been reconstructed as mangroves using root anatomy, peat taphonomy, and geochemical data. Macrofloral, palynofloral, and conodont biostratigraphy indicate that these peats come from the latest Atokan Blackoak coal and earliest Desmoinesian Cliffland coal (mid-Moscovian), both in the Kalo Formation. Thus, their depositional setting can be used to evaluate the mangrove hypothesis. In Recent mires, thick mangrove peats have accumulated in tropical to subtropical carbonate systems; in contrast, thick tropical freshwater peats have accumulated in siliclastic systems. Kalo Formation coals, which we interpret as freshwater deposits, formed in siliciclastic depositional settings, similar to those of modern tropical freshwater peat, and to other Pennsylvanian coals in North America interpreted as freshwater deposits. In the late Atokan and earliest Desmoinesian (mid-Moscovian), cordaiteans and tree ferns predominated in the Western Interior and Illinois Basins; lycopsids and cordaiteans predominated in the Appalachian and Donets Basins. The scarcity of lycopsid-only mires in North America during the late Atokan-earliest Desmoinesian (mid-Moscovian) suggests drier climates than during the mid-to-late Desmoinesian (late Moscovian). Rather than indicating mangrove swamps, cordaite-dominated peat may indicate climates with a 'low-rain' season. Although most plants in cordaite-dominated peat probably grew in freshwater, coastal mires in climate zones with seasons of 'low-rain' may harbor mangrove taxa. The Changuinola Swamp of Panama, a modern peat-accumulating wetland that has a 'low-rain' season, is a possible analog of ancient cordaite-dominated mires. In Changuinola, most plants require freshwater; however mangroves, sustained by salt-water influx into the swamp, grow along the seaward edge and along blackwater creeks. The 'low-rain' season hypothesis has implications for understanding rainfall amount and continuity during Pennsylvanian cyclothem deposition. The floral succession in diverse cordaite coals, from cordaiteans to tree ferns to lycopsids, suggests increasingly wet climate during coal accumulation. The position of these coals immediately above the sequence boundary suggests humid climate during early glacial melting for these cyclothems. (author)

  20. Reevaluation of the Braginskii viscous force for toroidal plasma

    Science.gov (United States)

    Johnson, Robert W.

    2011-12-01

    The model by Braginskii [1] (Braginskii, S. I. 1965 Transport processes in plasma. In: Review of Plasma Physics, Vol. 1 (ed. M.A. Leontovich). New York, NY: Consultants Bureau, pp. 205-311) for the viscous stress tensor is used to determine the shear and gyroviscous forces acting within a toroidally confined plasma. Comparison is made to a previous evaluation, which contains an inconsistent treatment of the radial derivative and neglects the effect of the pitch angle. Parallel viscosity contributes a radial shear viscous force, which may develop for sufficient vertical asymmetry to the ion velocity profile. An evaluation is performed of this radial viscous force for a tokamak near equilibrium, which indicates qualitative agreement between theory and measurement for impure plasma discharges with strong toroidal flow.

  1. Reevaluation of the Braginskii viscous force for toroidal plasma

    CERN Document Server

    Johnson, Robert W

    2009-01-01

    The model by Braginskii for the viscous stress tensor is used to determine the shear and gyroviscous forces acting within a toroidally confined plasma. Comparison is made to previous evaluations which contain an inconsistent treatment of the radial derivative and neglect the effect of the pitch angle. A radial gyroviscous force is found to survive the limit of constant density and rigid toroidal rotation of the flux surface, and a radial shear viscous force may develop for sufficient vertical asymmetry to the ion velocity profile.

  2. Taxonomic re-evaluation of black koji molds

    NARCIS (Netherlands)

    Hong, S.B.; Yamada, O.; Samson, R.A.

    2013-01-01

    Black koji molds including its albino mutant, the white koji mold, have been widely used for making the distilled spirit shochu in Northeast Asia because they produce citric acid which prevents undesirable contamination from bacteria. Since Inui reported Aspergillus luchuensis from black koji in Oki

  3. Re-Evaluating Risk and Exploring Educational Alternatives

    Science.gov (United States)

    Brown, Mike; Fraser, Deborah

    2009-01-01

    Risk is positioned as a distinguishing feature of outdoor adventure education (OAE) pedagogy. Risk defines much of what happens in OAE, from participants "taking" risks to instructors "managing" risks. The taken-for-granted centrality of risk continues to have currency due to the thrill and allure of adventurous outdoor activities. This paper…

  4. [Morphological Re-evaluation of the Basal Ganglia Network].

    Science.gov (United States)

    Fujiyama, Fumino

    2016-07-01

    Electrophysiological studies in monkeys have shown that dopaminergic neurons respond to the reward prediction error. In addition, striatal neurons alter their responsiveness to cortical or thalamic inputs in response to dopamine signals, via dopamine-regulated synaptic plasticity. These findings have led to the hypothesis that the striatum exhibits synaptic plasticity under the influence of reward prediction error and conducts reinforcement learning throughout the basal ganglia circuits. The reinforcement learning model is useful; however, the mechanism by which such a process emerges in the basal ganglia needs to be anatomically explained. The actor-critic model has been previously proposed and extended by the existence of role sharing within the striatum, with particular focus on the striosome and matrix compartments. However, this hypothesis has been difficult to confirm morphologically, partly because of the complex structure of the striosome and matrix compartments. Here, we review recent morphological studies that elucidate the input/output organization of the striatal compartments. PMID:27395470

  5. The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation

    Directory of Open Access Journals (Sweden)

    Giorgio Cozza

    2015-01-01

    Full Text Available Many polyphenolic compounds have been reported to inhibit protein kinases, with special reference to CK2, a pleiotropic serine/threonine kinase, implicated in neoplasia, neurodegenerative disease, and viral infections. In general however these compounds are not endowed with stringent selectivity. Among them quinalizarin (1,2,5,8-tetrahydroxyanthraquinone turned out to be particularly potent (Ki = 0.058 μM and quite selective as judged by profiling it on a small panel of 70 protein kinases. Here, by profiling quinalizarin on a larger panel of 140 kinases we reach the conclusion that quinalizarin is one of the most selective inhibitors of CK2, superior to the first-in-class CK2 inhibitor, CX-4945, now in clinical trials for the treatment of cancer. Moreover here we show that quinalizarin is able to discriminate between the isolated CK2 catalytic subunit (CK2α and CK2 holoenzyme (CK2α2β2, consistent with in silico and in vitro analyses.

  6. Reevaluating the Role of LTD in Cerebellar Motor Learning

    NARCIS (Netherlands)

    M. Schonewille (Martijn); Z. Gao (Zhenyu); H.J. Boele (Henk-Jan); M.F. Vinueza Veloz (Maria); W.E. Amerika; A. Šimek (Antonia); M.T.G. Jeu (Marcel); J. Steinberg (Jordan); K. Takamiya (Kogo); F.E. Hoebeek (Freek); D. Linden (David); R. Huganir (Richard); C.I. de Zeeuw (Chris)

    2011-01-01

    textabstractLong-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been proposed to be required for cerebellar motor learning. To date, tests of this hypothesis have sought to interfere with receptors (mGluR1) and enzymes (PKC, PKG, or αCamKII) necessary for induction of PF-PC

  7. Re-Evaluation of Reportedly Metal Tolerant Arabidopsis thaliana Accessions

    Science.gov (United States)

    Silva-Guzman, Macarena; Addo-Quaye, Charles; Dilkes, Brian P.

    2016-01-01

    Santa Clara, Limeport, and Berkeley are Arabidopsis thaliana accessions previously identified as diversely metal resistant. Yet these same accessions were determined to be genetically indistinguishable from the metal sensitive Col-0. We robustly tested tolerance for Zn, Ni and Cu, and genetic relatedness by growing these accessions under a range of Ni, Zn and Cu concentrations for three durations in multiple replicates. Neither metal resistance nor variance in growth were detected between them and Col-0. We re-sequenced the genomes of these accessions and all stocks available for each accession. In all cases they were nearly indistinguishable from the standard laboratory accession Col-0. As Santa Clara was allegedly collected from the Jasper Ridge serpentine outcrop in California, USA we investigated the possibility of extant A. thaliana populations adapted to serpentine soils. Botanically vouchered Arabidopsis accessions in the Jepson database were overlaid with soil maps of California. This provided no evidence of A. thaliana collections from serpentine sites in California. Thus, our work demonstrates that the Santa Clara, Berkeley and Limeport accessions are not metal tolerant, not genetically distinct from Col-0, and that there are no known serpentine adapted populations or accessions of A. thaliana. PMID:27467746

  8. Tell el Yahudiyeh Ware: a re-evaluation

    International Nuclear Information System (INIS)

    The TY (Tell el Yahudiyeh ware) project has implications for understanding the cultural interactions. The Second Intermediate Period (1750-1550 B.C.), one during which centraized government in Egypt collapses and, it is generally assumed, so does her trade network. Foreigners - the Hyksos - are able to enter the country and rule at least part of it. Results of this study (which includes activation analysis), however, indicate the TY is primarily an Egyptian pottery which appeared before the Hyksos entered and may have continued in use after they left. It cannot, therefore, be tightly associated with the Hyksos nor can it be used to judge the extent of their influence. Its wide distribution shows that Egypt continued to trade goods outside her boundaries throughout this period. Finally, not only goods travelled between what were generally considered to have been hostile neighbors, but the trade appears to have included ideas and technology as well

  9. Makeham's addition to the Gompertz law re-evaluated.

    Science.gov (United States)

    Hallén, Anund

    2009-08-01

    The Makeham parameter, a constant mortality rate independent of aging added to the Gompertz law of human mortality, is proposed to be a measure of the impact on mortality rate by extrinsic causes of mortality, with the effect of aging removed. A small intrinsic contribution to mortality, assumed to depend on the components involved in cellular function, is linked to the initial mortality rate of the Gompertz law. To avoid biased results and conclusions, the impact of extrinsic mortality should be eliminated from the Gompertz parameters.

  10. Reevaluation of RINT1 as a breast cancer predisposition gene.

    Science.gov (United States)

    Li, Na; Thompson, Ella R; Rowley, Simone M; McInerny, Simone; Devereux, Lisa; Goode, David; Investigators, LifePool; Wong-Brown, Michelle W; Scott, Rodney J; Trainer, Alison H; Gorringe, Kylie L; James, Paul A; Campbell, Ian G

    2016-09-01

    Rad50 interactor 1 (RINT1) has recently been reported as an intermediate-penetrance (odds ratio 3.24) breast cancer susceptibility gene, as well as a risk factor for Lynch syndrome. The coding regions and exon-intron boundaries of RINT1 were sequenced in 2024 familial breast cancer cases previously tested negative for BRCA1, BRCA2, and PALB2 mutations and 1886 population-matched cancer-free controls using HaloPlex Targeted Enrichment Assays. Only one RINT1 protein-truncating variant was detected in a control. No excess was observed in the total number of rare variants (truncating and missense) (28, 1.38 %, vs. 27, 1.43 %. P > 0.999) or in the number of variants predicted to be pathogenic by various in silico tools (Condel, Polyphen2, SIFT, and CADD) in the cases compared to the controls. In addition, there was no difference in the incidence of classic Lynch syndrome cancers in RINT1 rare variant-carrying families compared to RINT1 wild-type families. This study had 90 % power to detect an odds ratio of at least 2.06, and the results do not provide any support for RINT1 being a moderate-penetrance breast cancer susceptibility gene, although larger studies will be required to exclude more modest effects. This study emphasizes the need for caution before designating a cancer predisposition role for any gene based on very rare truncating variants and in silico-predicted missense variants. PMID:27544226

  11. Excess Barium as a Paleoproductivity Proxy: A Reevaluation

    Science.gov (United States)

    Eagle, M.; Paytan, A.

    2001-12-01

    Marine barite may serve as a proxy to reconstruct past export production (Dymond, 1992). In most studies sedimentary barite accumulation is not measured directly, instead a parameter termed excess barium (Baexs), also referred to as biogenic barium, is used to estimate the barite content. Baexs is defined as the total Ba concentration in the sediment minus the Ba associated with terrigenous material. Baexs is calculated by normalization to a constant Ba/Al ratio, typically the average shale ratio. This application assumes that (1) all the Ba besides the fraction associated with terrigenous Al is in the form of barite (the phase related to productivity) (2) the Ba/Alshale is constant in space and time (3) all of the Al is associated with terrigenous matter. If these assumptions are invalidated however, this approach lead to significant errors in calculating export production rates. To test the validity of the use of Baexs as a proxy for barite we compared the Baexs in a wide range of core top sediments from different oceanic settings to the barite content in the same cores. We found that Baexs frequently overestimated the Ba fraction associated with barite and in several cases significant Baexs was measured in the cores where no barite was observed. We have also used a sequential leaching protocol (Collier and Edmond 1984) to determine Ba association with organic matter, carbonates, Fe-Mn hydroxides and silicates. While terrigenous Ba remains an important fraction, in our samples 25-95% of non-barite Ba was derived from other fractions, with Fe-Mn oxides contributing the most Ba. In addition we found that the Ba/Al ratio in the silicate fraction of our samples varied considerably from site to site. The above results suggest that at least two of the underlying assumptions for employing Baexs to reconstruct paleoproductivity are not always valid and previously published data from (Murray and Leinen 1993) indicate that the third assumption may also not hold in every oceanic regime. We conclude that using Baexs instead of direct estimates of barite accumulation rates in sediment cores may result in significant errors in estimating past productivity and this proxy should only be used when it is clear that the associated assumptions are valid throughout the cores used. Collier, R. and J. M. Edmond (1984). "The trace elements geochemistry of marine biogenic particulate matter." Progress in Oceanography 13: 113-199. Dymond, J. (1992). "Barium in deep-sea sediment: A geochemical proxy for paleoproductivity." Paleoceanography 7(2): 163-181. Murray, R. W. and M. Leinen (1993). "Chemical transport to the seafloor of the equatorial Pacific Ocean across a latitudinal transect at 135ºW: Tracking sedimentary major, trace, and rare earth element fluxes at the Equator and the Intertropical Convergence Zone." Geochimica et Cosmochimica Acta 57: 4141-4163.

  12. A Critical Reevaluation of Radio Constraints on Annihilating Dark Matter

    Energy Technology Data Exchange (ETDEWEB)

    Cholis, Ilias [Fermilab; Hooper, Dan [Fermilab; Linden, Tim [Chicago U., KICP

    2015-04-03

    A number of groups have employed radio observations of the Galactic center to derive stringent constraints on the annihilation cross section of weakly interacting dark matter. In this paper, we show that electron energy losses in this region are likely to be dominated by inverse Compton scattering on the interstellar radiation field, rather than by synchrotron, considerably relaxing the constraints on the dark matter annihilation cross section compared to previous works. Strong convective winds, which are well motivated by recent observations, may also significantly weaken synchrotron constraints. After taking these factors into account, we find that radio constraints on annihilating dark matter are orders of magnitude less stringent than previously reported, and are generally weaker than those derived from current gamma-ray observations.

  13. Re-evaluating the 1940s CO2 plateau

    Science.gov (United States)

    Bastos, Ana; Ciais, Philippe; Barichivich, Jonathan; Bopp, Laurent; Brovkin, Victor; Gasser, Thomas; Peng, Shushi; Pongratz, Julia; Viovy, Nicolas; Trudinger, Cathy M.

    2016-09-01

    The high-resolution CO2 record from Law Dome ice core reveals that atmospheric CO2 concentration stalled during the 1940s (so-called CO2 plateau). Since the fossil-fuel emissions did not decrease during the period, this stalling implies the persistence of a strong sink, perhaps sustained for as long as a decade or more. Double-deconvolution analyses have attributed this sink to the ocean, conceivably as a response to the very strong El Niño event in 1940-1942. However, this explanation is questionable, as recent ocean CO2 data indicate that the range of variability in the ocean sink has been rather modest in recent decades, and El Niño events have generally led to higher growth rates of atmospheric CO2 due to the offsetting terrestrial response. Here, we use the most up-to-date information on the different terms of the carbon budget: fossil-fuel emissions, four estimates of land-use change (LUC) emissions, ocean uptake from two different reconstructions, and the terrestrial sink modelled by the TRENDY project to identify the most likely causes of the 1940s plateau. We find that they greatly overestimate atmospheric CO2 growth rate during the plateau period, as well as in the 1960s, in spite of giving a plausible explanation for most of the 20th century carbon budget, especially from 1970 onwards. The mismatch between reconstructions and observations during the CO2 plateau epoch of 1940-1950 ranges between 0.9 and 2.0 Pg C yr-1, depending on the LUC dataset considered. This mismatch may be explained by (i) decadal variability in the ocean carbon sink not accounted for in the reconstructions we used, (ii) a further terrestrial sink currently missing in the estimates by land-surface models, or (iii) LUC processes not included in the current datasets. Ocean carbon models from CMIP5 indicate that natural variability in the ocean carbon sink could explain an additional 0.5 Pg C yr-1 uptake, but it is unlikely to be higher. The impact of the 1940-1942 El Niño on the observed stabilization of atmospheric CO2 cannot be confirmed nor discarded, as TRENDY models do not reproduce the expected concurrent strong decrease in terrestrial uptake. Nevertheless, this would further increase the mismatch between observed and modelled CO2 growth rate during the CO2 plateau epoch. Tests performed using the OSCAR (v2.2) model indicate that changes in land use not correctly accounted for during the period (coinciding with drastic socioeconomic changes during the Second World War) could contribute to the additional sink required. Thus, the previously proposed ocean hypothesis for the 1940s plateau cannot be confirmed by independent data. Further efforts are required to reduce uncertainty in the different terms of the carbon budget during the first half of the 20th century and to better understand the long-term variability of the ocean and terrestrial CO2 sinks.

  14. Sympatric speciation by sexual selection : A critical reevaluation

    NARCIS (Netherlands)

    van Doorn, G.S.; Dieckmann, U.; Weissing, F.J.

    2004-01-01

    Several empirical studies put forward sexual selection as an important driving force of sympatric speciation. This idea agrees with recent models suggesting that speciation may proceed by means of divergent Fisherian runaway processes within a single population. Notwithstanding this, the models so f

  15. Re-evaluating green marketing strategy : a stakeholder perspective

    OpenAIRE

    Rivera Camino, Jaime

    2007-01-01

    Purpose The present study aims to examine the influence of stakeholders on green marketing strategy (GMS). Marketing literature recognizes that stakeholders play a significant role in influencing organizations and markets, but has not targeted a single integrated approach to examine the relationship between stakeholder management and GMS. Design/methodology/approach This research comprised several phases, including the development of a typology of GMS, an analysis of how manage...

  16. Locally advanced pancreatic adenocarcinoma. Chemoradiotherapy, reevaluation and secondary resection; Adenocarcinomes pancreatiques localement evolues. Chimioradiotherapie, reevaluation et resection secondaire?

    Energy Technology Data Exchange (ETDEWEB)

    Delpero, J.R.; Turrini, O. [Institut Paoli-Calmettes, Dept. de chirurgie, 13 - Marseille (France)

    2006-11-15

    Induction chemoradiotherapy (CRT) may down-stage locally advanced pancreatic tumors but secondary resections are unfrequent. However some responders' patients may benefit of a RO resection. Patients and methods. We report 18 resections among 29 locally advanced pancreatic cancers; 15 patients were treated with neo-adjuvant 5-FU-cisplatin based (13) or taxotere based (2 patients) chemoradiotherapy (45 Gy), and 3 patients without histologically proven adenocarcinoma were resected without any preoperative treatment. Results. The morbidity rate was 28% and the mortality rate was 7%; one patient died after resection (5.5%) and one died after exploration (9%). The RO resection rate was 50%. The median survival for the resected patients was not reached and the actuarial survival at 3 years was 59%. Two specimens showed no residual tumor and the two patients were alive at 15 and 46 months without recurrence; one specimen showed less than 10% viable tumoral cells and the patient was alive at 36 months without recurrence. A mesenteric infarction was the cause of a late death at 3 years in a disease free patient (radiation induced injury of the superior mesenteric artery). The median survival of the 11 non-resected patients was 21 months and the actuarial survival at 2 years was 0%. When the number of the resected patients (18) was reported to the entire cohort of the patients with locally advanced pancreatic cancer treated during the same period in our institution, the secondary resectability rate was 9%. Conclusion. Preoperative chemoradiotherapy identifies poor surgical candidates through observation and may enhance the margin status of patients undergoing secondary resection for locally advanced tumors. However it remains difficult to evaluate the results in the literature because of the variations in the definitions of resectability. The best therapeutic strategy remains to be defined, because the majority of patients ultimately succumb with distant metastatic disease. (author)

  17. 我国文献报道维生素D中毒病例诊断依据分析%Reevaluate of vitamin D intoxication diagnosis of reported cases in recent years in China and the criteria diagnosis and treatment of vitamin D intoxication

    Institute of Scientific and Technical Information of China (English)

    胡燕琪; 盛晓阳

    2011-01-01

    [Objectives] To reevaluate the diagnosis of vitamin D overdose and intoxication in reported cases in China, to improve the awareness of pediatricians on vitamin D overdose and intoxication, and to properly administrate vitamin D supplements. [Methods] All the cases of vitamin D overdose and intoxication reported from January 2004 till May 2010 in major domestic database had been searched by keywords "vitamin D" , "overdose" , "intoxication". The clinical manifestation, laboratory finding, treatment and prognosis of these cases had been reviewed. [Results] A total of 11 references had been searched. There were 475 cases of vitamin D overdose and intoxication had been reported in these references. Among them, 23 cases (4.8 %) meet vitamin D intoxication diagnosis criteria; 17 cases (3.6 % ) were overdose of vitamin D;234 cases (49.3%) could not be confirmed because incomplete information; 201 cases (42.3%) were misdiagnosis. [Conclusions] Almost half of cases are misdiagnosed vitamin D overdose and intoxication. Long-term prophylactic supplement vitamin D is very important to prevent and reduce vitamin D deficiency in children. However, precaution vitamin D abuse or misuse also should be emphasized.%[目的]分析和评估我国近年文献报道的维生素D过量和中毒病例,以期为临床医生正确认识维生素D中毒和预防性补充提供参考.[方法]检索国内主要数据库,收集2004年1月-2010年5月全部维生素D中毒、过量的文献报道,并对报道病例进行分析和总结.[结果]共检索到11篇文献,报道475例维生素D过量或中毒病例.依据目前维生素D过量和中毒诊断标准评估,其中仅23例(4.8%)符合维生素D中毒诊断;17例(3.6%)明确维生素D过量;234例(49.3%)无法肯定诊断;201例(42.3%)缺乏必要诊断依据.[结论]近年来我国确实存在维生素D中毒病例,但部分报道病例诊断依据明显不足.临床医生应警惕维生素D的滥用或误用,同时提高对长

  18. Morris水迷宫测评方法的改进及对快速老化痴呆小鼠SAMP8认知功能的再评价%Improvements of Morris Water Maze Evaluation Method and Re-evaluation of the Rapid Aaging Dementia SAMP8 Cognitive Function in Mice

    Institute of Scientific and Technical Information of China (English)

    刘金凤; 聂坤; 栗振杰; 徐思思; 张莹; 孙金平; 张雪竹

    2013-01-01

    Objective: To improve evaluation of the Morris water maze,which make it more suitable for the e-valuation of the cognitive function of mice. And re-evaluate the cognitive function of the rapid aging dementia mice the SAMP8 (senescence accelerated mouse prone 8). Methods: The SAMP8 group and its homologous normal control mice SAMR1 (senescence accelerated mouse resistant 1) were taken as the research object,and the e-valuation of the Morris water maze conditions was optimized. The effect of the mice spatial reference memory capacity by into water point position,the number of daily swim,test order,color and ect were researched. Results: The SAMP8 mice escape latency in each part of the test significantly was longer than SAMR1 mice. SAMP8 mice swam slower than SAMR1 mice. SAMP8 mice their own swimming speed remained stable during the test. Groups latency show no difference on the first day of change the test method.The SAMP8 mice search strategy were mostly random type and edge-type while the SAMR1 mice were linear type and tend type. Conclusion: Explore trials interspersed in hidden and reverse platform test is more effective in test mice short-term learning memory abilities. The scores of the first day after changing test method can not be the standard of evaluate the learning and memory abilities of mice. 4-5 times a day, the number of training does not affect the swimming speed of the mice. SAMP8 mice is a good animal model to study age-related learning and memory deficits.%目的 改进Morris水迷宫的测评方法,使之更适于评价小鼠的认知功能,并对快速老化痴呆小鼠SAMP8的认知功能进行再评价.方法 以SAMP8组及其正常同源对照小鼠SAMR1为研究对象,优化Morris水迷宫的测评条件,研究入水点位置、每日游泳次数、试验次序、颜色等对其空间参考记忆能力的影响.结果 SAMP8小鼠在各部分试验的逃避潜伏期明显长于SAMR1小鼠;SAMP8小鼠比SAMR1小鼠的游泳速度慢,自身

  19. Re-evaluation of China’s Position in International Division from the Dual Perspectives of Export Technological Sophistication and Domestic Value Added%中国国际分工地位的再评估∗--基于出口技术复杂度与国内增加值双重视角的分析

    Institute of Scientific and Technical Information of China (English)

    苏庆义

    2016-01-01

    合理地评估当前中国的国际分工地位是判断中国的出口优势与劣势以及提升中国的国际分工地位的重要依据。文章将出口技术复杂度和国内增加值率结合起来,构建了同时具有产品属性和增加值属性的国际分工地位新指标,并基于投入产出框架构建了理解国际分工地位差异的理论模型,进而对中国的国际分工地位进行了再评估。结果表明:(1)考虑服务业出口后,目前中国的国际分工地位处于最为落后的经济体行列,亚洲新兴经济体的国际分工地位普遍不高,发达经济体和资源丰富的经济体拥有较高的国际分工地位。(2)1995-2009年中国与美国、印度和巴西之间的分工地位差距有所扩大,与德国之间的分工地位差距比较稳定,而与日本之间的分工地位差距则有所缩小。(3)结构分解的分析显示,中国国际分工地位落后的主要原因是出口结构问题,即服务业出口比重过低,而国内增加值率的降低也在发挥越来越重要的影响。(4)中国国际分工地位指数的变动主要源于产业属性效应和国内增加值效应,而出口结构效应的影响则较低。因此,调整出口结构和提升国内增加值率是中国未来提升国际分工地位的两种重要方式。%Reasonable evaluation of current China’s position in international division is the key basis of j udging China’s export strengths and weaknesses as well as improving its position in international division.This paper constructs a new index of position in international division pos-sessing both product and domestic value added attributes by integrating export technological sophistication and domestic value added.Then it constructs a theoretical model about understanding the differences in positions in international division based on input-output framework,and re-eval-uates China’s position in international division.It draws the results as

  20. Personnel radiation protection. Situation of the dosimetry surveillance of external exposure in 2003; La radioprotection des travailleurs. Bilan de la surveillance dosimetrique de l'exposition externe en 2003

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    The situation of external exposure of workers for the year 2003 has been realised according to the same method than this one of the year 2002. It does not show big variations of trends, both in term of workforce watched and collective doses alike associated in the different sectors of activity. Some differences observed between the two years can explain by real evolutions of situations. For example, the 2800 workers registered in the veterinary sector are the result of a better awareness of this profession for the radiation protection during the last months. Some variations can be the results of artefacts in the data processing. The centralization at I.R.S.N. of the whole of dosimetry data should allow to make easy the data treatment and to improve the statistics of occupational exposure. (N.C.)

  1. Dosimetric comparison of IMRT and modulated arc-therapy techniques in the treatment of cervical cancers; Comparaison dosimetrique des techniques de RCMI et d'arctherapie modulee dans le traitement des cancers du col uterin

    Energy Technology Data Exchange (ETDEWEB)

    Renard-Oldrini, S.; Charra-Brunaud, C.; Tournier-Rangeard, L.; Huger, S.; Marchesi, V.; Bouziz, D.; Peiffert, D. [Centre Alexis-Vautrin, Nancy (France)

    2011-10-15

    The authors report the dosimetric comparison of two techniques used for the treatment of cervical cancers: the intensity-modulated conformational radiotherapy (IMRT) with static beams and modulated arc-therapy with RapidArc. The treatment plans of 15 patients have been compared. The clinical target volume (CTV) comprises the gross target volume, the cervix, the upper third of the vagina, and ganglionary areas. The previsional target volume comprises the clinical target volume and a one centimetre margin. Organs at risk are rectum, bladder, intestine and bone marrow. Arc-therapy seems to provide a better sparing of intestine that IMRT, while maintaining a good coverage of the previsional target volume and decreasing treatment duration. Short communication

  2. Extended helical tomo-therapy and concomitant chemotherapy for an uterine cervix carcinoma: dosimetry parameters and hematological toxicity; Tomotherapie helicoidale etendue et chimiotherapie concomitante pour un cancer du col de l'uterus: parametres dosimetriques et toxicite hematologique

    Energy Technology Data Exchange (ETDEWEB)

    Haddad, H.; Thomas, L.; Belhomme, S.; Chemin, A.; Caron, J.; Dejean, C.; Kantor, G.; Richaud, P. [Institut Bergonie, Dept. de Radiotherapie, 33 - Bordeaux (France); Floquet, A.; Guyon, F. [Institut Bergonie, Dept. de Chirurgie, 33 - Bordeaux (France)

    2009-10-15

    the extended tomo-therapy associated to concomitant chemotherapy is feasible and allows a dose escalation at the ganglions level. It is necessary to continue to study the dosimetry parameters at the hematopoietic marrow level that are predictive for a hematological toxicity. (N.C.)

  3. Realisation of dosimetric studies for workplaces with a risk of exposure to ionizing radiations (version 2). Practical guide; Realisation des etudes dosimetriques de poste de travail presentant un risque d'exposition aux rayonnements ionisants (version 2). Guide pratique

    Energy Technology Data Exchange (ETDEWEB)

    Donadille, L.; Rehel, J.L.; Deligne, J.M.; Queinnec, F.; Aubert, B.; Bottollier-Depois, J.F.; Clairand, I.; Jourdain, J.R.; Rannou, A.

    2010-07-01

    This guide proposes a methodological approach to help carry out dosimetric workplace studies complying with the french regulation, and necessary to identify risks of radiological exposure, optimize radiation protection, classify the workers into different categories and the workplaces into different areas. Additional information is provided relating the main objectives of a workplace study, the French regulatory context, main sources and pathways of exposure to ionizing radiation. Radiation protection and operational quantities are reminded. Recommendations about the selection and use of detectors and about the implementation of calculation methods are also provided. The general methodological approach is applied and developed into 'workplace sheets', each one devoted to a particular type of workplace. (authors)

  4. Mortality study among veterans with dosimeter monitoring during the French nuclear tests in the Pacific; Etude de mortalite des veterans ayant beneficie d'une surveillance dosimetrique lors des essais nucleaires francais dans le Pacifique

    Energy Technology Data Exchange (ETDEWEB)

    Pedrono, G.; Pachol, H.; Segala, C. [SEPIA-sante, 31, rue de Pontivy, 56150 Baud (France)

    2011-06-15

    Background: A mortality study was carried out in a cohort of veterans present on the sites of the French nuclear experiments center in the Pacific (CEP) from 1966 to 1996, and for whom external dosimeter monitoring recordings were available. Methods: The cohort included 32,550 veterans having had at least one dosimetry recording. Current vital status was collected from the National Register of Identification of Physical People and causes of death data from the national causes of death database. Total mortality and mortality by cause were compared with mortality of the French population using standardized mortality ratios (SMR). To test the effect of a dosimeter recording higher than the threshold (0.2 mSv), i.e., no null dosimetry, the mortality of veterans was compared inside the cohort, using standardized ratios and Poisson regression models. Results: The mortality analysis was performed among 26,524 men, of whom 8% had had at least one non-null dosimeter. Five thousand four hundred and ninety-two (21%) veterans died before December 31, 2008 and causes were available for nearly 97% of these deaths. Comparing the mortality between the cohort and the French population highlighted a deficit of mortality, for all causes, by cancer and for radiation-induced pathologies; these results were related to the 'healthy worker effect'. The data showed that all causes mortality and cancer mortality of the cohort of veterans with no null dosimeter were not different from those of other veterans, but also showed an excess of hematological malignancies in this sub-population: this excess was significant in the regression model (RR = 1.82; CI 95% [1.6-2.0]). Conclusion: Among veterans with an external dosimeter monitoring recording, presence on the sites of CEP from 1966 to 1996 does not constitute a factor of increased mortality compared with the national population. However, an increased risk was observed for mortality by hematological malignancies among veterans with no null dosimetry. This result is in line with studies on veterans present during nuclear experiments abroad. (authors)

  5. Organ motion study and dosimetric impact of respiratory gating radiotherapy for esophageal cancer; Etude de mobilite organique et impact dosimetrique de l'asservissement respiratoire dans la radiotherapie des cancers de l'oesophage

    Energy Technology Data Exchange (ETDEWEB)

    Lorchel, F

    2007-04-15

    Chemoradiotherapy is now the standard treatment for locally advanced or inoperable esophageal carcinoma. In this indication, conformal radiotherapy is generally used. However, prognosis remains poor for these patients. Respiratory gating radiotherapy can decrease healthy tissues irradiation and allows escalation dose in lung, liver and breast cancer. In order to improve radiotherapy technique, we propose to study the feasibility of respiratory gating for esophageal cancer. We will study the respiratory motions of esophageal cancer to optimize target volume delineation, especially the internal margin (I.M.). We will test the correlation between tumour and chest wall displacements to prove that esophageal cancer motions are induced by respiration. This is essential before using free breathing respiratory gating systems. We will work out the dosimetric impact of respiratory gating using various dosimetric analysis parameters. We will compare dosimetric plans at end expiration, end inspiration and deep inspiration with dosimetric plan in free-breathing condition. This will allow us to establish the best respiratory phase to irradiate for each gating system. This dosimetric study will be completed with linear quadratic equivalent uniform dose (E.U.D.) calculation for each volume of interest. Previously, we will do a theoretical study of histogram dose volume gradation to point up its use. (author)

  6. Dose comparison between three planing prostate: 3-D conformational radiotherapy, coplanar arc therapy and non-coplanar arc therapy; Comparaison dosimetrique de trois balistiques prostatiques: radiotherapie conformationnelle tridimensionnelle, arctherapie coplanaire et arctherapie non-coplanaire

    Energy Technology Data Exchange (ETDEWEB)

    Voyant, C.; Baadj, A.; Biffi, K.; Leschi, D.; Lantieri, C. [Centre Hospitalier Dept. Castelluccio, Service de Radiotherapie, Ajaccio (France); Voyant, C. [Universite de Corse, Lab. SPE, CNRS-UMR 6134, Corte (France)

    2008-09-15

    Purpose: Comparative study between a classical conformational prostate radiotherapy (3 D.R.T.C.) and two arc therapy techniques, a coplanar (A.T.-C) and the other non-coplanar (A.T.-N.C.). Patients and Methods:The comparison has been made retrospectively on 30 patients with localized prostate cancer (T.2-T.3a, P.S.A. < 20 ng/ml, Gleason < 7). The objective criteria for comparison were the N.T.C.P., E.U.D., and dose volume (on D.V.H.), for the volumes of bladder wall, rectal wall, femoral heads, small bowel, prostate (P) and seminal vesicles (V.S.). The treatment was 46 Gy on P.T.V.1 (V.S. + P + margins), and then an overdose of 30 Gy on P.T.V.1 (P + margins). Results: For prostate volumes exceeding 75 cm{sup 3}, arc therapy leads to a decrease in uniformity in the target volume and an increase in the dose received by the femoral heads, this method does not seem appropriate. For prostate volumes less than 75 cm{sup 3}, in addition to the coverage almost tumor, and radiation toxicity equivalent to the bladder and the small intestine, there is a significant increase in the dose to the femoral heads, while the remaining is still within limits, such as clinically tolerable. The contribution of arc therapy is mainly observed at the level of rectal doses. The dose received by 30% of the rectum is reduced by - 12% for A.T.-C and - 11.7% for A.T-N.C., and E.U.D. rectum - 5.2% and - 4.8%. Conclusion: In this virtual study, the arc therapy seems to generate a true dose reduction in the rectum wall. These results encourage us to continue the investigation for a possible integration in a dynamic clinical routine. (authors)

  7. Recommendations for the target volume definition on dosimetry scanning in the oropharynx cancers; Recommandations pour la definition d'un volume cible sur scanographie dosimetrique dans les cancers de l'oropharynx

    Energy Technology Data Exchange (ETDEWEB)

    Maingon, P. [Centre Georges-Francois-Leclerc, Dept. de Radiotherapie, 21 - Dijon (France); Gregoire, V. [Hopital Universitaire Saint Luc, Dept. d' Oncologie Radiotherapie et Lab. de Radiologie, Brussels (Belgium)

    2004-11-01

    The oropharynx includes the base of tongue, tonsil pillars, soft palate, lateral and posterior wall of the hypopharynx. Tumors involving each part of these areas are often treated by external beam radiation therapy. The development of conformal approaches and the implementation of intensity modulated radiation therapy, combined with accurate definition of target volumes, endorsed by the international community, allows to propose guidelines for definition of target volumes. First of all imaging acquisition for dosimetry is reminded. For tumors involving the base of tongue and vallecula, early superficial tumors should be distinguished from tumors involving the muscles, indicating an increased margin defining the clinical target volume around the tumor to 1.5 cm. Tumors developed in the posterior wall of the hypopharynx should include constrictor muscles of the pharynx inside of the CTV. Tonsil carcinomas should be treated with a 1.5 cm margin around the tumor in the three dimensions. In spite of modern imaging, external beam treatment of tumors developed in the soft palate and in palatine arch remains difficult. The high rate of nodal involvement of these tumors and significant rates of bilateral extension have to be taken into consideration. Accurate criteria have been available to integrate a probability of bilateral extension in oropharynx 1 tumors. It should be analyzed according to the size of the tumor and the rate of extension in the base of the tongue and in the palatine arch. (authors)

  8. Radiotherapy of breast cancers: dosimetry comparison of irradiation complement of the surgical field by photons and electrons; Radiotherapie des cancers du sein: comparaison dosimetrique des complements d'irradiation du lit operatoire par photons et electrons

    Energy Technology Data Exchange (ETDEWEB)

    Hajji, Z.; Lorchel, F.; Barbet, N.; Pouchard, I.; Khodri, M. [Centre de Radiotherapie, 71 - Macon (France)

    2009-10-15

    Purpose: to quantify the dosimetry differences between two plans of irradiation complement of the surgical bed by photons and electrons. Conclusion: We observe a significant difference in favour of photons in term of homogeneity, recovery around the P.T.V. and pulmonary irradiation, at the detriment of a deterioration of the external volume index, attesting of a larger irradiation of the mammary gland. (N.C.)

  9. Quality control of the treatment planning systems dose calculations in external radiation therapy using the Penelope Monte Carlo code; Controle qualite des systemes de planification dosimetrique des traitements en radiotherapie externe au moyen du code Monte-Carlo Penelope

    Energy Technology Data Exchange (ETDEWEB)

    Blazy-Aubignac, L

    2007-09-15

    The treatment planning systems (T.P.S.) occupy a key position in the radiotherapy service: they realize the projected calculation of the dose distribution and the treatment duration. Traditionally, the quality control of the calculated distribution doses relies on their comparisons with dose distributions measured under the device of treatment. This thesis proposes to substitute these dosimetry measures to the profile of reference dosimetry calculations got by the Penelope Monte-Carlo code. The Monte-Carlo simulations give a broad choice of test configurations and allow to envisage a quality control of dosimetry aspects of T.P.S. without monopolizing the treatment devices. This quality control, based on the Monte-Carlo simulations has been tested on a clinical T.P.S. and has allowed to simplify the quality procedures of the T.P.S.. This quality control, in depth, more precise and simpler to implement could be generalized to every center of radiotherapy. (N.C.)

  10. Justification and dosimetric issues for new CT practice: heart-scan, colon-scan and full body scan; Justification et enjeux dosimetriques des nouvelles pratiques scanographiques: coroscanner, coloscanner, scanner corps entier

    Energy Technology Data Exchange (ETDEWEB)

    Vidal, Vincent; Moulin, Guy; Bartoli, Jean-Michel [Service de radiologie, Hopital de la Timone, 264, rue Saint Pierre, 13385 Marseille Cedex 5 (France)

    2011-07-15

    The goals of the new computed tomography techniques are to improve diagnostic quality while being less invasive. These examinations have to be justified, in other words their clinical indication has to be confirmed, along with the choice of this technique as being the most appropriate. Correctly managed use of these tools ensures that the patients are guaranteed a risk/benefit ratio that is frequently better than that of other medical exploratory methods. New procedures such as CT colonography and coronary CT angiography are currently being evaluated, even if these examinations can already be justified on the basis of their improved tolerance, rapidity and cost. In any case, in the same way as any other irradiating examination, they must comply in all respects with the ALARA principle. (authors)

  11. Reevaluation of spin-dependent WIMP-proton interactions as an explanation of the DAMA data

    CERN Document Server

    Del Nobile, Eugenio; Georgescu, Andreea; Huh, Ji-Haeng

    2015-01-01

    We reexamine the interpretation of the annual modulation signal observed by the DAMA experiment as due to WIMPs with a spin-dependent coupling mostly to protons. We consider both axial-vector and pseudo-scalar couplings, and elastic as well as endothermic and exothermic inelastic scattering. We conclude that the DAMA signal is in strong tension with null results of other direct detection experiments, particularly PICASSO and KIMS.

  12. Re-evaluating "transitional neonatal hypoglycemia": mechanism and implications for management

    Science.gov (United States)

    A Committee of the Pediatric Endocrine Society was recently formed to develop guidelines for evaluation and management of hypoglycemia in neonates, infants, and children. To aid in formulating recommendations for neonates, in this review, we analyzed available data on the brief period of hypoglycemi...

  13. Re-Evaluation of the AASHTO-Flexible Pavement Design Equation with Neural Network Modeling

    Science.gov (United States)

    Tiğdemir, Mesut

    2014-01-01

    Here we establish that equivalent single-axle loads values can be estimated using artificial neural networks without the complex design equality of American Association of State Highway and Transportation Officials (AASHTO). More importantly, we find that the neural network model gives the coefficients to be able to obtain the actual load values using the AASHTO design values. Thus, those design traffic values that might result in deterioration can be better calculated using the neural networks model than with the AASHTO design equation. The artificial neural network method is used for this purpose. The existing AASHTO flexible pavement design equation does not currently predict the pavement performance of the strategic highway research program (Long Term Pavement Performance studies) test sections very accurately, and typically over-estimates the number of equivalent single axle loads needed to cause a measured loss of the present serviceability index. Here we aimed to demonstrate that the proposed neural network model can more accurately represent the loads values data, compared against the performance of the AASHTO formula. It is concluded that the neural network may be an appropriate tool for the development of databased-nonparametric models of pavement performance. PMID:25397962

  14. The social psychology of seismic hazard adjustment: re-evaluating the international literature

    Science.gov (United States)

    Solberg, C.; Rossetto, T.; Joffe, H.

    2010-08-01

    The majority of people at risk from earthquakes do little or nothing to reduce their vulnerability. Over the past 40 years social scientists have tried to predict and explain levels of seismic hazard adjustment using models from behavioural sciences such as psychology. The present paper is the first to synthesise the major findings from the international literature on psychological correlates and causes of seismic adjustment at the level of the individual and the household. It starts by reviewing research on seismic risk perception. Next, it looks at norms and normative beliefs, focusing particularly on issues of earthquake protection responsibility and trust between risk stakeholders. It then considers research on attitudes towards seismic adjustment attributes, specifically beliefs about efficacy, control and fate. It concludes that an updated model of seismic adjustment must give the issues of norms, trust, power and identity a more prominent role. These have been only sparsely represented in the social psychological literature to date.

  15. Evaluation and re-evaluation of genetic radiation hazards in man

    International Nuclear Information System (INIS)

    A detailed presentation is made of the experimental data from the various systems used by Abrahamson to conclude that the per locus per rad (low LET) radiation-induced forward mutation rates in organisms whose DNA content varies by a factor of about 1000, is proportional to genome size. Additional information pertinent in this context is also reviewed. It is emphasized that the mutation rates cited by Abrahamson, although considered as pertaining to mutations at specific loci, actually derive from a broad variety of genetic end-points. It is argued that an initial (if not sufficient) condition for sound interspecific mutation rate comparisons, covering a wide range of organisms and detecting systems of various sensitivities, requires a reasonably consistent biological definition of a specific locus mutation, namely, a transmissible intralocus change. Granting the differences between systems in their resolving power to detect intergenic change, the data cited in this paper do not support the existence of a simple proportionality between radiation-induced intralocus mutation rate and genome size for the different species reviewed here

  16. Re-evaluating low-energy neutron-deuteron elastic scattering using three-nucleon theory

    Energy Technology Data Exchange (ETDEWEB)

    Svenne, J.P. [Manitoba Univ., Dept. of Physics and Astronomy, Winnipeg Institute for Theoretical Phyiscs, Winnipeg, Manitoba (Canada); Canton, L. [Fisica dell' Universita di Padova, Istituto Nazionale di Fisica Nucleare, sezione di Padova e Dipt., Padova (Italy); Kozier, K. [Atomic Energy of Canada Limited, Chalk River Laboratories, Chalk River, ON (Canada); Townsend, L. [Tennessee Univ., Dept. of Nuclear Engineering, TN (United States)

    2008-07-01

    Using a well-established nucleon-nucleon interaction that fits the NN scattering data (Bonn potential), and the AGS form of three-body theory, we perform precise calculations of low-energy neutron-deuteron scattering. There appear to be problems for this system in the Endf/B-VI.8 (Endf/B-VI.5 through VI.8) data library, which persist in the newest version, Endf/B-VII.0. Supporting experimental data in this energy region are rather old (>25 years), sparse and often inconsistent. Our three-body results at low energies, 50 keV to 10 MeV are compared to the Endf/B-VII.0 and JENDL-3.3 evaluated angular distributions. The impact of these results on calculated reactivity for various critical systems involving heavy water is shown.We conclude that, if the Endf/B-VII.0 data for {sup 2}H are flawed, our next preference, based on the lower CVR bias value, are theoretical results from AGS calculations using the Bonn-B NN interaction. Our other main conclusion is that modern nuclear model calculations produce results for practical applications that are noticeably different, and likely better, than those based on older Faddeev calculations with a simple Yamaguchi potential.

  17. Scientific Opinion on the re-evaluation of aspartame (E 951 as a food additive

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Food Additives and Nutrient Sources added to food (ANS

    2013-12-01

    Full Text Available The EFSA ANS Panel provides a scientific opinion on the safety of aspartame (E 951. Aspartame is a sweetener authorised as a food additive in the EU. In previous evaluations by JECFA and the SCF, an ADI of 40 mg/kg bw/day was established based on chronic toxicity in animals. Original reports, previous evaluations, additional literature and data made available following a public call were evaluated. Aspartame is rapidly and completely hydrolysed in the gastrointestinal tract to phenylalanine, aspartic acid and methanol. Chronic and developmental toxicities were relevant endpoints in the animal database. From chronic toxicity studies in animals, a NOAEL of 4000 mg/kg bw/day was identified. The possibility of developmental toxicity occurring at lower doses than 4000 mg/kg in animals could not be excluded. Based on MoA and weight-of-evidence analysis, the Panel concluded that developmental toxicity in animals was attributable to phenylalanine. Phenylalanine at high plasma levels is known to cause developmental toxicity in humans. The Panel concluded that human data on developmental toxicity were more appropriate for the risk assessment. Concentration-response modelling was used to determine the effects of aspartame administration on plasma phenylalanine using human data after phenylalanine administration to normal, PKU heterozygote or PKU homozygote individuals. In normal and PKU heterozygotes, aspartame intakes up to the ADI of 40 mg/kg bw/day, in addition to dietary phenylalanine, would not lead to peak plasma phenylalanine concentrations above the current clinical guideline for the prevention of adverse effects in fetuses. The Panel concluded that aspartame was not of safety concern at the current aspartame exposure estimates or at the ADI of 40 mg/kg bw/day. Therefore, there was no reason to revise the ADI of aspartame. Current exposures to aspartame - and its degradation product DKP - were below their respective ADIs. The ADI is not applicable to PKU patients.

  18. Reevaluating the Mass-Radius Relation for Low-mass, Main-sequence Stars

    Science.gov (United States)

    Feiden, Gregory A.; Chaboyer, Brian

    2012-09-01

    We examine the agreement between the observed and theoretical low-mass (models. The new grid allows for a realistic variation in the age and metallicity of the DEB population, characteristic of the local galactic neighborhood. Overall, our models do a reasonable job of reproducing the observational data. A large majority of the models match the observed stellar radii to within 4%, with a mean absolute error of 2.3%. These results represent a factor of two improvement compared to previous examinations of the low-mass mass-radius relationship. The improved agreement between models and observations brings the radius deviations within the limits imposed by potential starspot-related uncertainties for 92% of the stars in our DEB sample.

  19. Reevaluating the Mass-Radius Relation for Low-Mass, Main Sequence Stars

    CERN Document Server

    Feiden, Gregory A

    2012-01-01

    We examine the agreement between the observed and theoretical low-mass (< 0.8 solar masses) stellar main sequence mass-radius relationship by comparing detached eclipsing binary (DEB) data with a new, large grid of stellar evolution models. The new grid allows for a realistic variation in the age and metallicity of the DEB population, characteristic of the local galactic neighborhood. Overall, our models do a reasonable job of reproducing the observational data. A large majority of the models match the observed stellar radii to within 4%, with a mean absolute error of 2.3%. These results represent a factor of two improvement compared to previous examinations of the low-mass mass-radius relationship. The improved agreement between models and observations brings the radius deviations within the limits imposed by potential starspot-related uncertainties for 92% of the stars in our DEB sample.

  20. Re-evaluating Open Source for Sustaining Competitive Advantage for Hosted Applications

    Directory of Open Access Journals (Sweden)

    Daniel Crenna

    2010-03-01

    Full Text Available The use of open source in hosted solutions is undoubtedly widespread. However, it is seldom considered important in its own right, nor do the majority of hosted solutions providers contribute to or create open source as natural artifacts of doing good business. In this exploration of the nature of hosted solutions and their developers, it is suggested that not only consuming open source, but creating and disseminating it to collaborators and competitors alike, is essential to success. By establishing an open source ecosystem where hosted solutions compete on differentiation rather than lose time and money to concerns that are expected by users, do not add value, and benefit from public scrutiny, hosted solution providers can reduce the cost of their solution, the time it takes to deliver new ones, and improve their quality without additional resources.

  1. Males Resemble Females: Re-Evaluating Sexual Dimorphism in Protoceratops andrewsi (Neoceratopsia, Protoceratopsidae.

    Directory of Open Access Journals (Sweden)

    Leonardo Maiorino

    Full Text Available Protoceratops andrewsi (Neoceratopsia, Protoceratopsidae is a well-known dinosaur from the Upper Cretaceous of Mongolia. Some previous workers hypothesized sexual dimorphism in the cranial shape of this taxon, using qualitative and quantitative observations. In particular, width and height of the frill as well as the development of a nasal horn have been hypothesized as potentially sexually dimorphic.Here, we reassess potential sexual dimorphism in skulls of Protoceratops andrewsi by applying two-dimensional geometric morphometrics to 29 skulls in lateral and dorsal views. Principal Component Analyses and nonparametric MANOVAs recover no clear separation between hypothetical "males" and "females" within the overall morphospace. Males and females thus possess similar overall cranial morphologies. No differences in size between "males" and "females" are recovered using nonparametric ANOVAs.Sexual dimorphism within Protoceratops andrewsi is not strongly supported by our results, as previously proposed by several authors. Anatomical traits such as height and width of the frill, and skull size thus may not be sexually dimorphic. Based on PCA for a data set focusing on the rostrum and associated ANOVA results, nasal horn height is the only feature with potential dimorphism. As a whole, most purported dimorphic variation is probably primarily the result of ontogenetic cranial shape changes as well as intraspecific cranial variation independent of sex.

  2. Re-evaluating the Frankfurt isothermal static diffusion chamber for ice nucleation

    OpenAIRE

    J. Schrod; A. Danielczok; Weber, D.; M. Ebert; Thomson, E. S.; H. G. Bingemer

    2015-01-01

    Recently significant advances have been made in the collection, detection, and characterization of ice nucleating particles (INP). Ice nuclei are particles that facilitate the heterogeneous formation of ice within the atmospheric aerosol by lowering the free energy barrier to spontaneous nucleation and growth of ice from atmospheric water and/or vapor. The Frankfurt isostatic diffusion chamber (FRIDGE) is an INP collection and offline detection system that has become widely deployed and sho...

  3. Re-evaluating the Frankfurt isothermal static diffusion chamber for ice nucleation

    OpenAIRE

    Schrod, Jann; Danielczok, Anja; Weber, Daniel; Ebert, Martin; Thomson, Erik S.; Bingemer, Heinz G.

    2016-01-01

    Recently significant advances have been made in the collection, detection and characterization of ice nucleating particles (INPs). Ice nuclei are particles that facilitate the heterogeneous formation of ice within the atmospheric aerosol by lowering the free energy barrier to spontaneous nucleation and growth of ice from atmospheric water and/or vapor. The Frankfurt isostatic diffusion chamber (FRankfurt Ice nucleation Deposition freezinG Experiment: FRIDGE) is an INP collecti...

  4. Reevaluation of whether a soma-to-germ-line transformation extends lifespan in Caenorhabditis elegans.

    Science.gov (United States)

    Knutson, Andrew Kekūpa'a; Rechtsteiner, Andreas; Strome, Susan

    2016-03-29

    The germ lineage is considered to be immortal. In the quest to extend lifespan, a possible strategy is to drive germ-line traits in somatic cells, to try to confer some of the germ lineage's immortality on the somatic body. Notably, a study in Caenorhabditis elegans suggested that expression of germ-line genes in the somatic cells of long-lived daf-2 mutants confers some of daf-2's long lifespan. Specifically, mRNAs encoding components of C. elegans germ granules (P granules) were up-regulated in daf-2 mutant worms, and knockdown of individual P-granule and other germ-line genes in daf-2 young adults modestly reduced their lifespan. We investigated the contribution of a germ-line program to daf-2's long lifespan and also tested whether other mutants known to express germ-line genes in their somatic cells are long-lived. Our key findings are as follows. (i) We could not detect P-granule proteins in the somatic cells of daf-2 mutants by immunostaining or by expression of a P-granule transgene. (ii) Whole-genome transcript profiling of animals lacking a germ line revealed that germ-line transcripts are not up-regulated in the soma of daf-2 worms compared with the soma of control worms. (iii) Simultaneous removal of multiple P-granule proteins or the entire germ-line program from daf-2 worms did not reduce their lifespan. (iv) Several mutants that robustly express a broad spectrum of germ-line genes in their somatic cells are not long-lived. Together, our findings argue against the hypothesis that acquisition of a germ-cell program in somatic cells increases lifespan and contributes to daf-2's long lifespan. PMID:26976573

  5. Re-evaluation of Cryptosporiopsis eucalypti and Cryptosporiopsis-like species occurring on Eucalyptus

    NARCIS (Netherlands)

    Cheewangkoon, R.; Groenewald, J.Z.; Verkley, G.J.M.; Hyde, K.D.; Wingfield, M.J.; Gryzenhout, M.; Summerell, B.A.; Denman, S.; Toanan, C.; Crous, P.W.

    2010-01-01

    Cryptosporiopsis eucalypti is a common follicolous pathogen of Eucalyptus species in tropical and temperate regions where these trees are grown in plantations. The taxonomy of C. eucalypti is confused by the fact that it is phylogenetically unrelated to the type species of Cryptosporiopsis (Cryptosp

  6. Re-evaluation of Cryptosporiopsis eucalypti and Cryptosporiopsis-like species occurring on Eucalyptus

    OpenAIRE

    Cheewangkoon, R.; Groenewald, J.Z.; Verkley, G.J.M.; Hyde, K.D.; Wingfield, M.J.; Gryzenhout, M.; Summerell, B.A.; Denman, S; Toanan, C.; Crous, P.W.

    2010-01-01

    Cryptosporiopsis eucalypti is a common follicolous pathogen of Eucalyptus species in tropical and temperate regions where these trees are grown in plantations. The taxonomy of C. eucalypti is confused by the fact that it is phylogenetically unrelated to the type species of Cryptosporiopsis (Cryptosporiopsis nigra = C. scutellata, Helotiales). The aim of this study was to resolve the taxonomic position of C. eucalypti based on morphology and phylogenetic inference. Thirty-two Eucalyptus leaf s...

  7. Re-evaluation of Cryptosporiopsis eucalypti and Cryptosporiopsis-like species occurring on Eucalyptus leaves

    NARCIS (Netherlands)

    Cheewangkoon, R.; Groenewald, J.Z.; Verkley, G.J.M.; Hyde, K.D.; Wingfield, M.J.; Gryzenhout, M.; Summerell, B.A.; Denman, S.; Toanun, C.; Crous, P.W.

    2010-01-01

    Cryptosporiopsis eucalypti is a common follicolous pathogen of Eucalyptus species in tropical and temperate regions where these trees are grown in plantations. The taxonomy of C. eucalypti is confused by the fact that it is phylogenetically unrelated to the type species of Cryptosporiopsis (Cryptosp

  8. Medial prefrontal cortical activity reflects dynamic re-evaluation during voluntary persistence.

    Science.gov (United States)

    McGuire, Joseph T; Kable, Joseph W

    2015-05-01

    Deciding how long to keep waiting for future rewards is a nontrivial problem, especially when the timing of rewards is uncertain. We carried out an experiment in which human decision makers waited for rewards in two environments in which reward-timing statistics favored either a greater or lesser degree of behavioral persistence. We found that decision makers adaptively calibrated their level of persistence for each environment. Functional neuroimaging revealed signals that evolved differently during physically identical delays in the two environments, consistent with a dynamic and context-sensitive reappraisal of subjective value. This effect was observed in a region of ventromedial prefrontal cortex that is sensitive to subjective value in other contexts, demonstrating continuity between valuation mechanisms involved in discrete choice and in temporally extended decisions analogous to foraging. Our findings support a model in which voluntary persistence emerges from dynamic cost/benefit evaluation rather than from a control process that overrides valuation mechanisms. PMID:25849988

  9. Reevaluation of the plant "gemstones": Calcium oxalate crystals sustain photosynthesis under drought conditions.

    Science.gov (United States)

    Tooulakou, Georgia; Giannopoulos, Andreas; Nikolopoulos, Dimosthenis; Bresta, Panagiota; Dotsika, Elissavet; Orkoula, Malvina G; Kontoyannis, Christos G; Fasseas, Costas; Liakopoulos, Georgios; Klapa, Maria I; Karabourniotis, George

    2016-09-01

    Land plants face the perpetual dilemma of using atmospheric carbon dioxide for photosynthesis and losing water vapors, or saving water and reducing photosynthesis and thus growth. The reason behind this dilemma is that this simultaneous exchange of gases is accomplished through the same minute pores on leaf surfaces, called stomata. In a recent study we provided evidence that pigweed, an aggressive weed, attenuates this problem exploiting large crystals of calcium oxalate as dynamic carbon pools. This plant is able to photosynthesize even under drought conditions, when stomata are closed and water losses are limited, using carbon dioxide from crystal decomposition instead from the atmosphere. Abscisic acid, an alarm signal that causes stomatal closure seems to be implicated in this function and for this reason we named this path "alarm photosynthesis." The so-far "enigmatic," but highly conserved and widespread among plant species calcium oxalate crystals seem to play a crucial role in the survival of plants.

  10. Reevaluation of the 131I thyroid uptake in Rio de Janeiro

    International Nuclear Information System (INIS)

    The values of the 3 and 24 hour thyroid radioiodine uptake were analysed in 919 of the patients examined during 1977-1980. Reference values determined for 95% of the normal population are 2.5 - 17.5% for the 3 hour thyroid uptake values, and 10.5 - 41.2% for the 24 hour values. The non-toxic diffuse goiter group has significantly higher mean values than normals or patients with non-toxic nodular goiters and cold nodules, their upper values reaching 24.7% and 52.9% for 3 and 24 hour uptake. The discriminatory power of the test for non-toxic diffuse goiters may be increased if higher limits than those determined for normals are used in day to day routine. Values of 20% for 3 hour uptake and 45% for the 24 hour uptake improve diagnosis in these patients without seriously reducing the capacity for identification of thyrotoxicosis. A value greater than 0.6 for the ratio between the 3 hour and 24 hour uptake can serve as a coadjuvant factor in the diagnosis of diffuse toxic goiters; values higher than 0.8 were found in less than 0.5% of the non-toxic patients. (Author)

  11. Need of reevaluation of the parameters of semen straws to be used in artificial insemination programs

    Directory of Open Access Journals (Sweden)

    J. Angel

    2010-02-01

    Full Text Available In buffalo industry artificial insemination is being used in breeding programs of our country . It has limitations such us seasonality, difficult estrus detection and low pregnancy rates when compared with cattle. IATF programs using a single insemination show results from 10 to 50% pregnancy rate, little information is available about minimum requirements of spermatozoa for IA. The aim of this paper is to compare the pregnancy rates after using narual mating or frozen semen in a sincronization of ovulation program. This work were conducted in Pueblo Nuevo Cordoba Colombia in August during the breeding season of 2005-6. 99 multiparous crossbred females were used with 50 to 150 postpartum days. Body score condition of 3,5 to 4. All animals were palpated to exclude anatomical alterations. Ovsynch protocol for IATF reported by Baruselli (2000, they were allocated in two groups: Buffalo group, after the last GnRH analog injection 17 females were allocated with 5 bulls, and IATF Group 82 females were inseminated 16 hours later. The semen of 7 different buffalo bulls were used and evaluated and qualified as normal. Inseminations were performed by 3 different technicians. A blood sample was obtained 20 days after IA to determine pregnancy by determinations of P4 levels using chemiluminiscence, ≥1ng/ml were used as cut off value to determine pregnancy. Data were compared using Chi square test. 70% (12/17 females of the bull group and 29% (24/82 of IATF group were diagnosed us pregnant using P4, this difference were statistically significant (P≤0.001. Buffalo bulls mount all females. No statistical differences were found in pregnancy rates of the bulls used for IATF, from 12% to 37 %, one exceptional bull obtain 71%. As expected bulls have higher pregnancy rates than artificial insemination, the results obtained here allow researchers to evaluated semen quality, specially density to improve results IATF in buffaloes.

  12. It is time to reevaluate the management of patients with brain metastases.

    Science.gov (United States)

    Kondziolka, Douglas; Kalkanis, Steven N; Mehta, Minesh P; Ahluwalia, Manmeet; Loeffler, Jay S

    2014-07-01

    There are many elements to the science that drives the clinical care of patients with brain metastases. Although part of an understanding that continues to evolve, a number of key historical misconceptions remain that commonly drive physicians' and researchers' attitudes and approaches. By understanding how these relate to current practice, we can better comprehend our available science to provide both better research and care. These past misconceptions include: Misconception 1: Once a primary cancer spreads to the brain, the histology of that primary tumor does not have much impact on response to chemotherapy, sensitivity to radiation, risk of further brain relapse, development of additional metastatic lesions, or survival. All tumor primary histologies are the same once they spread to the brain. They are the same in terms of the number of tumors, radiosensitivity, chemoresponsiveness, risk of further brain relapse, and survival. Misconception 2: The number of brain metastases matters. This number matters in terms of subsequent brain relapse, survival, and cognitive dysfunction; the precise number of metastases can also be used as a limit in determining which patients might be eligible for a particular treatment option. Misconception 3: Cancer in the brain is always a diffuse problem due to the presence of micrometastases. Misconception 4: Whole-brain radiation therapy invariably causes disabling cognitive dysfunction if a patient lives long enough. Misconception 5: Most brain metastases are symptomatic. Thus, it is not worth screening patients for brain metastases, especially because the impact on survival is minimal. The conduct and findings of past clinical research have led to conceptions that affect clinical care yet appear limiting. PMID:24662510

  13. Relapse surveillance in AFP-positive hepatoblastoma: re-evaluating the role of imaging

    Energy Technology Data Exchange (ETDEWEB)

    Rojas, Yesenia; Vasudevan, Sanjeev A.; Nuchtern, Jed G. [Baylor College of Medicine, Pediatric Surgery Division, Michael E. DeBakey Department of Surgery, Texas Children' s Hospital, Houston, TX (United States); Guillerman, R.P. [Baylor College of Medicine, Department of Pediatric Radiology, Texas Children' s Hospital, Houston, TX (United States); Zhang, Wei [Texas Children' s Hospital, Surgical Outcomes Center, Houston, TX (United States); Thompson, Patrick A. [Baylor College of Medicine, Hematology-Oncology Division, Department of Pediatrics, Texas Children' s Cancer Center, Texas Children' s Hospital, Houston, TX (United States); University of North Carolina, Hematology-Oncology Division, Department of Pediatrics, North Carolina Children' s Hospital, Chapel Hill, NC (United States)

    2014-10-15

    Children with hepatoblastoma routinely undergo repetitive surveillance imaging, with CT scans for several years after therapy, increasing the risk of radiation-induced cancer. The purpose of this study was to determine the utility of surveillance CT scans compared to serum alpha-fetoprotein (AFP) levels for the detection of hepatoblastoma relapse. This was a retrospective study of all children diagnosed with AFP-positive hepatoblastoma from 2001 to 2011 at a single institution. Twenty-six children with hepatoblastoma were identified, with a mean age at diagnosis of 2 years 4 months (range 3 months to 11 years). Mean AFP level at diagnosis was 132,732 ng/ml (range 172.8-572,613 ng/ml). Five of the 26 children had hepatoblastoma relapse. A total of 105 imaging exams were performed following completion of therapy; 88 (84%) CT, 8 (8%) MRI, 5 (5%) US and 4 (4%) FDG PET/CT exams. A total of 288 alpha-fetoprotein levels were drawn, with a mean of 11 per child. The AFP level was elevated in all recurrences and no relapses were detected by imaging before AFP elevation. Two false-positive AFP levels and 15 false-positive imaging exams were detected. AFP elevation was found to be significantly more specific than PET/CT and CT imaging at detecting relapse. We recommend using serial serum AFP levels as the preferred method of surveillance in children with AFP-positive hepatoblastoma, reserving imaging for the early postoperative period, for children at high risk of relapse, and for determination of the anatomical site of clinically suspected recurrence. Given the small size of this preliminary study, validation in a larger patient population is warranted. (orig.)

  14. RE-EVALUATION OF THE MECHANISM AND TREATMENT OF ANGINA DECUBITUS

    Institute of Scientific and Technical Information of China (English)

    陈纪林; 陈在嘉; 徐义枢; 高润霖; 寇文蓉; 姚康宝; 于全俊; 陶寿琪

    1996-01-01

    30 patients with angina decubittus(AD) were studied during hospitalization. These patients were found to have severe coronary artery obstructive lesions and an increase of myocardial oxygen consumption (MOC) before the onset to AD, indicating that AD belongs to the category of effort angina. 18 patients were investigated by continuous hemodynamic mordtoring. Three patients had significant increase in pulmonary artery diastolic pressure (PADP) before the onset. In the other 15 patients, PADP increased slightly in J2 and remained unchanged in 3 cases before the onset. Left ventriculography showed ejection fraction (EF))45% in 25 of the 27 patients. These results indicate that left ventricular (LV) systolic dysfunction is not a major factor in the pathogenesis of AD. The patients with LVEDP>12 mmHg constituted 60% of 25 patients with EF)45%, suggesting that these patients had obvious LV diastolic dysfunction, which may he the major factor in the pathogenesis of AD. According to the results of our treatment, Beta blockers may be used as the major form of treatment in the patients with AD.

  15. Was John Dewey Ethnocentric? Reevaluating the Philosopher's Early Views on Culture and Race

    Science.gov (United States)

    Fallace, Thomas D.

    2010-01-01

    In this historical study, the author explores the early racial and cultural views of John Dewey. The author argues that, during his years at the University of Chicago, when he wrote the majority of his works on education, Dewey considered American non-White minorities to be biologically equal to Whites but socially deficient. In particular, Dewey…

  16. Reevaluating Data Stall Time with the Consideration of Data Access Concurrency

    Institute of Scientific and Technical Information of China (English)

    刘宇航; 孙贤和

    2015-01-01

    Data access delay has become the prominent performance bottleneck of high-end computing systems. The key to reducing data access delay in system design is to diminish data stall time. Memory locality and concurrency are the two essential factors influencing the performance of modern memory systems. However, existing studies in reducing data stall time rarely focus on utilizing data access concurrency because the impact of memory concurrency on overall memory system performance is not well understood. In this study, a pair of novel data stall time models, the L-C model for the combined effort of locality and concurrency and the P-M model for the effect of pure miss on data stall time, are presented. The models provide a new understanding of data access delay and provide new directions for performance optimization. Based on these new models, a summary table of advanced cache optimizations is presented. It has 38 entries contributed by data concurrency while only has 21 entries contributed by data locality, which shows the value of data concurrency. The L-C and P-M models and their associated results and opportunities introduced in this study are important and necessary for future data-centric architecture and algorithm design of modern computing systems.

  17. Learning to love what we despise: Experiential re-evaluation of stigmatised technologies

    DEFF Research Database (Denmark)

    Scholderer, Joachim; Grunert, Klaus G.; Søndergaard, Helle Alsted

    modified organisms or their derivatives. In the absence of product experience, consumers tend to evaluate this technology by setting it into relation to other, even more and general socio-political attitudes. Previous research has shown that these attitudes are resistant to all forms of communicative......Commercialization of novel technologies may be hampered by stakeholder resistance and a sceptical public. Genetic modification has suffered particularly from such stigma; at present, practically no products exist on the shelves of European retailers that are labelled as containing genetically...... interventions. A study is presented in which the effectiveness and mechanisms of direct-experience interventions are experimentally tested. Results indicate that even a single trial of a high-quality genetically modified food can lead to strong changes in consumer attitudes (effect size d = .40). Furthermore...

  18. Re-Evaluating Geothermal Potential with GIS Methods and New Data: Williston Basin, North Dakota

    Science.gov (United States)

    Crowell, A. M.; Gosnold, W. D.; UND Geothermal Laboratory

    2011-12-01

    The University of North Dakota Geothermal Laboratory is working on the National Geothermal Data Aggregation project in conjunction with Southern Methodist University (SMU) and other partners, and funded by the Department of Energy to collect data for exploration and utilization of resources for geothermal power production. We have examined 10,951 wells in the Williston Basin to determine accurate methods for estimating power extraction potential in a sedimentary basin. The calculations we used involved defining the area of wells within designated ranges and calculating the geothermal fluid reservoir volume using porosity data from the North Dakota Geological Survey Wilson M. Laird Core Library. We defined the parameters for our calculations as: bottom-hole temperature (BHT), formation thickness data, surface area of the polygon around wells within the temperature range, and porosity data. The wells in each formation with a BHT over 90°C were imported into ArcGIS, buffered to 1.6 kilometers from centroid, and outlined with a polygon feature to define the surface area. We then included average formation thickness to determine an approximate volume for ten water and rock reservoirs. In calculating this available energy the following three assumptions were made; that 1/1000 of the water volume is available to use per year, that the temperature is lowered to 50°C during electrical power production, and that the efficiency of the binary power plant utilized is 14%. The estimated recoverable energy in the volume of rock containing geothermal fluids by temperature range is as follows: 1.32 x 108 MW for 90°-100° C, 1.92 x 108 MW for 100°-110° C, 2.15 x 108 MW for 110°-120° C, 2.4 x 108 MW for 120°-130° C, 1.4 x 108 MW for 130°-140° C, 4.95 x 107 MW for 140°-150° C, and 3.67 x 107 MW for 150° C and up.

  19. Reevaluating the Concept of Treating Experimental Tumors with a Mixed Bacterial Vaccine: Coley's Toxin

    OpenAIRE

    Maletzki, C.; Klier, U.; W. Obst; Kreikemeyer, B.; Linnebacher, M

    2012-01-01

    Several decades after Coley's initial work, we here systematically analyzed tumoricidal as well as immunostimulatory effects of the historical preparation Coley's Toxin (CT), a safe vaccine made of heat-inactivated S. pyogenes and S. marcescens. First, by performing in vitro analysis, established human pancreatic carcinoma cell lines responded with dose- and time-dependent growth inhibition. Effects were attributed to necrotic as well as apoptotic cell death as determined by increased Caspase...

  20. Re-evaluation of a bacterial antifreeze protein as an adhesin with ice-binding activity.

    Directory of Open Access Journals (Sweden)

    Shuaiqi Guo

    Full Text Available A novel role for antifreeze proteins (AFPs may reside in an exceptionally large 1.5-MDa adhesin isolated from an Antarctic Gram-negative bacterium, Marinomonas primoryensis. MpAFP was purified from bacterial lysates by ice adsorption and gel electrophoresis. We have previously reported that two highly repetitive sequences, region II (RII and region IV (RIV, divide MpAFP into five distinct regions, all of which require mM Ca(2+ levels for correct folding. Also, the antifreeze activity is confined to the 322-residue RIV, which forms a Ca(2+-bound beta-helix containing thirteen Repeats-In-Toxin (RTX-like repeats. RII accounts for approximately 90% of the mass of MpAFP and is made up of ∼120 tandem 104-residue repeats. Because these repeats are identical in DNA sequence, their number was estimated here by pulsed-field gel electrophoresis. Structural homology analysis by the Protein Homology/analogY Recognition Engine (Phyre2 server indicates that the 104-residue RII repeat adopts an immunoglobulin beta-sandwich fold that is typical of many secreted adhesion proteins. Additional RTX-like repeats in RV may serve as a non-cleavable signal sequence for the type I secretion pathway. Immunodetection shows both repeated regions are uniformly distributed over the cell surface. We suggest that the development of an AFP-like domain within this adhesin attached to the bacterial outer surface serves to transiently bind the host bacteria to ice. This association would keep the bacteria within the upper reaches of the water column where oxygen and nutrients are potentially more abundant. This novel envirotactic role would give AFPs a third function, after freeze avoidance and freeze tolerance: that of transiently binding an organism to ice.

  1. Re-evaluating the Frankfurt isothermal static diffusion chamber for ice nucleation

    Directory of Open Access Journals (Sweden)

    J. Schrod

    2015-12-01

    Full Text Available Recently significant advances have been made in the collection, detection, and characterization of ice nucleating particles (INP. Ice nuclei are particles that facilitate the heterogeneous formation of ice within the atmospheric aerosol by lowering the free energy barrier to spontaneous nucleation and growth of ice from atmospheric water and/or vapor. The Frankfurt isostatic diffusion chamber (FRIDGE is an INP collection and offline detection system that has become widely deployed and shows additional potential for ambient measurements. Since its initial development FRIDGE has gone through several iterations and improvements. Here we describe improvements that have been made in the collection and analysis techniques. We detail the uncertainties inherent in the measurement method, and suggest a systematic method of error analysis for FRIDGE measurements. Thus what is presented herein should serve as a foundation for the dissemination of all current and future measurements using FRIDGE instrumentation.

  2. Using Rasch Modeling to Re-Evaluate Rapid Malaria Diagnosis Test Analyses

    Directory of Open Access Journals (Sweden)

    Dawit G. Ayele

    2014-06-01

    Full Text Available The objective of this study was to demonstrate the use of the Rasch model by assessing the appropriateness of the demographic, social-economic and geographic factors in providing a total score in malaria RDT in accordance with the model’s expectations. The baseline malaria indicator survey was conducted in Amhara, Oromiya and Southern Nation Nationalities and People (SNNP regions of Ethiopia by The Carter Center in 2007. The result shows high reliability and little disordering of thresholds with no evidence of differential item functioning.

  3. Reevaluation of whether a soma–to–germ-line transformation extends lifespan in Caenorhabditis elegans

    Science.gov (United States)

    Knutson, Andrew Kekūpa'a; Rechtsteiner, Andreas; Strome, Susan

    2016-01-01

    The germ lineage is considered to be immortal. In the quest to extend lifespan, a possible strategy is to drive germ-line traits in somatic cells, to try to confer some of the germ lineage’s immortality on the somatic body. Notably, a study in Caenorhabditis elegans suggested that expression of germ-line genes in the somatic cells of long-lived daf-2 mutants confers some of daf-2’s long lifespan. Specifically, mRNAs encoding components of C. elegans germ granules (P granules) were up-regulated in daf-2 mutant worms, and knockdown of individual P-granule and other germ-line genes in daf-2 young adults modestly reduced their lifespan. We investigated the contribution of a germ-line program to daf-2’s long lifespan and also tested whether other mutants known to express germ-line genes in their somatic cells are long-lived. Our key findings are as follows. (i) We could not detect P-granule proteins in the somatic cells of daf-2 mutants by immunostaining or by expression of a P-granule transgene. (ii) Whole-genome transcript profiling of animals lacking a germ line revealed that germ-line transcripts are not up-regulated in the soma of daf-2 worms compared with the soma of control worms. (iii) Simultaneous removal of multiple P-granule proteins or the entire germ-line program from daf-2 worms did not reduce their lifespan. (iv) Several mutants that robustly express a broad spectrum of germ-line genes in their somatic cells are not long-lived. Together, our findings argue against the hypothesis that acquisition of a germ-cell program in somatic cells increases lifespan and contributes to daf-2’s long lifespan. PMID:26976573

  4. Re-Evaluating and Exploring the Contributions of Constituency Grammar to Semantic Role Labeling

    Science.gov (United States)

    Yang, Li

    2009-01-01

    Since the seminal work of Gildea and Jurafsky (2000), semantic role labeling (SRL) researchers have been trying to determine the appropriate syntactic/semantic knowledge and statistical algorithms to tackle the challenges in SRL. In search of the appropriate knowledge, SRL researchers shifted from constituency grammar to dependency grammar around…

  5. A re-evaluation of the archaeal membrane lipid biosynthetic pathway

    NARCIS (Netherlands)

    Villanueva, L.; Sinninghe Damsté, J.S.; Schouten, S.

    2014-01-01

    Archaea produce unique membrane lipids in which isoprenoid alkyl chains are bound to glycerol moieties via ether linkages. As cultured representatives of the Archaea have become increasingly available throughout the past decade, archaeat genomic and membrane lipid-composition data have also become a

  6. Reevaluation of design waves off the western Indian coast considering climate change

    Digital Repository Service at National Institute of Oceanography (India)

    Satyavathi, P.; Deo, M.C.; Kerkar, J.; Vethamony, P.

    . This was done FIGURE 4 Selection of threshold and distribution for Hs (left) and Tz (right) values at location 19.The parameters of the above distributions were derived according to the method of maximum likelihood, which consists of maximizing the likelihood... and Tz along the coastline, although rise in Hs is accompanied by the rise in Tz as well. As regards stations 19 and 21, it may be mentioned that FIGURE 6 Projected versus historical 100-year Hs.hold true here. It is possible that, in the future...

  7. Biogeography of Mediterranean Hotspot Biodiversity: Re-Evaluating the 'Tertiary Relict' Hypothesis of Macaronesian Laurel Forests.

    Directory of Open Access Journals (Sweden)

    Paulina Kondraskov

    Full Text Available The Macaronesian laurel forests (MLF are dominated by trees with a laurophyll habit comparable to evergreen humid forests which were scattered across Europe and the Mediterranean in the Paleogene and Neogene. Therefore, MLF are traditionally regarded as an old, 'Tertiary relict' vegetation type. Here we address the question if key taxa of the MLF are relictual. We evaluated the relict hypothesis consulting fossil data and analyses based on molecular phylogenies of 18 representative species. For molecular dating we used the program BEAST, for ancestral trait reconstructions BayesTraits and Lagrange to infer ancestral areas. Our molecular dating showed that the origins of four species date back to the Upper Miocene while 14 originated in the Plio-Pleistocene. This coincides with the decline of fossil laurophyllous elements in Europe since the middle Miocene. Ancestral trait and area reconstructions indicate that MLF evolved partly from pre-adapted taxa from the Mediterranean, Macaronesia and the tropics. According to the fossil record laurophyllous taxa existed in Macaronesia since the Plio- and Pleistocene. MLF are composed of species with a heterogeneous origin. The taxa dated to the Pleistocene are likely not 'Tertiary relicts'. Some species may be interpreted as relictual. In this case, the establishment of most species in the Plio-Pleistocene suggests that there was a massive species turnover before this time. Alternatively, MLF were largely newly assembled through global recruitment rather than surviving as relicts of a once more widespread vegetation. This process may have possibly been triggered by the intensification of the trade winds at the end of the Pliocene as indicated by proxy data.

  8. Adrian Marino and the Ideea of Freedom. A Necesary Reevaluation and Challenge

    Directory of Open Access Journals (Sweden)

    Ionuţ COSTEA

    2011-01-01

    Full Text Available The study aims to highlight a turn in Marino Adrian's intellectual identity. This change wasconfirmed in memorialistic feature texts (dialogues, memories printed after the events of December1989 and it is seen at some program writings, which are militant in order to define a new Romanianculture, based on a real dialog with the West, animated by a critical spirit, being original andoriented through fundamental writings, synthesis and encyclopedias. If at cultural level, Marinoasserted his desire to build a new culture, at social level he believed in building up a civil society,dominated by the values of democracy and of human rights. In this context, Marino’s interest movesfrom the criticism and literary theory to the history of ideas and ideologies, in order to define aliberal culture necessary to the deep modernization and Europeanization of the Post communistRomania.1

  9. Re-evaluation of the use of low activation materials in waste management strategies for fusion

    International Nuclear Information System (INIS)

    The world fusion programs have had a long goal that fusion power stations should produce only low level waste and thus not pose a burden for the future generations. However, the environmental impact of waste material is determined not only by the level of activation, but also the total volume of activated material. Since a tokamak power plant is large, the potential to generate a correspondingly large volume of activated material exists. The adoption of low activation materials, while important for reducing the radiotoxicity of the most active components, should be done as part of a strategy that also minimizes the volume of waste material that might be categorized as radioactive, even if lower in level. In this paper we examine different fusion blanket and shield designs in terms of their ability to limit the activation of the large vessel/ex-vessel components (e.g. vacuum vessel, magnets) and we identify the trends that allow improved in-vessel shielding to result in reduced vessel/ex-vessel activation. Recycling and clearance are options for reducing the volume of radioactive waste in a fusion power plant. Thus, the performance of typical fusion power plant designs with respect to recycling and clearance criteria are also assessed, to show the potential for improvement in waste volume reduction by careful selection of materials' combinations. We discuss the impact of these results on fusion waste strategies and on the development of fusion power in the future

  10. Gall-bladder and colonic retention of SeHCAT: a re-evaluation

    International Nuclear Information System (INIS)

    A number of suggested alternatives and emendations to the 7-day SeHCAT retention test have been compared with whole-body counting. It was found that correction for colonic retention is an unnecessary complication in patients with diarrhoea and that imaging either of the gall-bladder or of the distribution of activity in the intestines at 24 h does not add useful information to the standard 7-day retention measurement. Neither could the patterns of colonic uptake identified in patients following extensive ideal resection or radiotherapy be reproduced in patients with idiopathic diarrhoea. Sadly it must be concluded that neither of these shortened techniques is of clinical value in patients with intact small bowel and that there remains no reliable alternative to the 7-day Se HCAT retention test. The simplest technique the best. (orig.)

  11. A re-evaluation of physical protection standards for irradiated HEU fuel

    International Nuclear Information System (INIS)

    In the post-September 11 era, it is essential to reconsider all the assumptions upon which the physical protection systems of the past were based and determine whether these assumptions are still appropriate in light of the current terrorist threat. For instance, the U.S. Nuclear Regulatory Commission definition of a 'formula quantity' of special nuclear material is derived from the belief that a terrorist plot to carry out multiple coordinated attacks on different facilities with the goal of acquiring enough SNM for a nuclear weapon is incredible. This assumption has clearly been proven wrong by the September 11 attacks. Another standard that needs to be revisited is the 'self-protection' threshold that determines whether or not an item containing SNM is considered to be 'irradiated' for physical protection purposes. The current value of this threshold, 1 Sv/hr unshielded at 1 meter, is of questionable value as a deterrent to determined terrorists who would be willing to sustain long-term injury as long as they could accomplish their near-term goals. A more credible threshold would be set at a level that would have a high likelihood of disabling the perpetrators before they could complete their mission. Most irradiated nonpower reactor fuels would be unable to meet such a standard. This raises serious questions about the adequacy of the level of physical protection applied today to the large inventories of irradiated HEU fuels now scattered in storage sites around the world. The absence of a coherent global policy for dealing with these materials has created a situation rife with vulnerabilities that terrorists could exploit. The international community, now seized with concern about unused stockpiles of unirradiated HEU fuels around the world, also needs to appreciate the dangers posed by lightly irradiated spent fuels as well. A U.S. proposal to import Russian HEU for supplying U.S. nonpower reactors will only prolong this situation This paper will review policy options to mitigate this threat. (author)

  12. Re-evaluation of the AASHTO-flexible pavement design equation with neural network modeling.

    Directory of Open Access Journals (Sweden)

    Mesut Tiğdemir

    Full Text Available Here we establish that equivalent single-axle loads values can be estimated using artificial neural networks without the complex design equality of American Association of State Highway and Transportation Officials (AASHTO. More importantly, we find that the neural network model gives the coefficients to be able to obtain the actual load values using the AASHTO design values. Thus, those design traffic values that might result in deterioration can be better calculated using the neural networks model than with the AASHTO design equation. The artificial neural network method is used for this purpose. The existing AASHTO flexible pavement design equation does not currently predict the pavement performance of the strategic highway research program (Long Term Pavement Performance studies test sections very accurately, and typically over-estimates the number of equivalent single axle loads needed to cause a measured loss of the present serviceability index. Here we aimed to demonstrate that the proposed neural network model can more accurately represent the loads values data, compared against the performance of the AASHTO formula. It is concluded that the neural network may be an appropriate tool for the development of databased-nonparametric models of pavement performance.

  13. Re-evaluation of the AASHTO-flexible pavement design equation with neural network modeling.

    Science.gov (United States)

    Tiğdemir, Mesut

    2014-01-01

    Here we establish that equivalent single-axle loads values can be estimated using artificial neural networks without the complex design equality of American Association of State Highway and Transportation Officials (AASHTO). More importantly, we find that the neural network model gives the coefficients to be able to obtain the actual load values using the AASHTO design values. Thus, those design traffic values that might result in deterioration can be better calculated using the neural networks model than with the AASHTO design equation. The artificial neural network method is used for this purpose. The existing AASHTO flexible pavement design equation does not currently predict the pavement performance of the strategic highway research program (Long Term Pavement Performance studies) test sections very accurately, and typically over-estimates the number of equivalent single axle loads needed to cause a measured loss of the present serviceability index. Here we aimed to demonstrate that the proposed neural network model can more accurately represent the loads values data, compared against the performance of the AASHTO formula. It is concluded that the neural network may be an appropriate tool for the development of databased-nonparametric models of pavement performance. PMID:25397962

  14. Re-evaluating Primary Biotic Resource Use for Marine Biomass Production: A New Calculation Framework.

    Science.gov (United States)

    Luong, Anh D; Schaubroeck, Thomas; Dewulf, Jo; De Laender, Frederik

    2015-10-01

    The environmental impacts of biomass harvesting can be quantified through the amount of net primary production required to produce one unit of harvested biomass (SPPR-specific primary production required). This paper presents a new calculation framework that explicitly takes into account full food web complexity and shows that the resulting SPPR for toothed whales in the Icelandic marine ecosystem is 2.8 times higher than the existing approach based on food web simplification. In addition, we show that our new framework can be coupled to food web modeling to examine how uncertainty on ecological data and processes can be accounted for while estimating SPPR. This approach reveals that an increase in the degree of heterotrophy by flagellates from 0% to 100% results in a two-fold increase in SPPR estimates in the Barents Sea. It also shows that the estimated SPPR is between 3.9 (herring) and 5.0 (capelin) times higher than that estimated when adopting food chain theory. SPPR resulting from our new approach is only valid for the given time period for which the food web is modeled and cannot be used to infer changes in SPPR when the food web is altered by changes in human exploitation or environmental changes. PMID:26348118

  15. Reevaluating the roles of large public surpluses and sovereign wealth funds in Asia

    OpenAIRE

    Lee, Bernard; Wang, Hefei

    2011-01-01

    This paper discusses the increasingly important roles of Asian official institutions in the new global financial landscape and the reasons that have led to the build-up of massive public surpluses. We re-examine the role of sovereign wealth funds (SWFs) as the de facto "global lender of last resort" during the recent financial crisis. Specifically, we analyze SWFs’ balance sheet characteristics, target allocations strategies, strategic agendas and political realities, management philosop...

  16. A re-evaluation of the determinants of glomerular filtration rate

    DEFF Research Database (Denmark)

    Karlsen, F M; Holstein-Rathlou, N H; Leyssac, P P

    1995-01-01

    Several factors are potentially able to change the glomerular filtration rate (GFR) and thereby participate in its regulation, but only a few factors seem to be physiologically important. The variable nature of proximal tubular pressure should be recognized as important in the regulation of GFR....... It is argued that a distinction should be made between the terms 'autoregulation of GFR' and 'regulation of GFR'. The tubuloglomerular feedback mechanism (TGF) is an important factor for autoregulatory control of GFR. When perturbations result in major increases in tubular flow, the TGF saturates. Proximal...... tubular pressure then increases and becomes the major factor responsible for the stabilization of GFR. Changes in the proximal reabsorption rate (APR) are important for long-term variations in GFR (regulation of GFR). Small changes in the APR cause near parallel changes in the GFR mainly through the TGF...

  17. Reevaluating geographic variation in life-history traits of a widespread Nearctic amphibian

    Science.gov (United States)

    Davenport, Jon M.; Hossack, Blake R.

    2016-01-01

    Animals from cold environments are usually larger than animals from warm environments, which often produce clines in body size. Because variation in body size can lead to trade-offs between growth and reproduction, life-history traits should also vary across climatic gradients. To determine if life-history traits of wood frogs Rana sylvatica vary with climate, we examined female and male body length, clutch size, and ovum size from 37 locations across an unprecedented 32° of latitude. In conflict with recent research, body size, and ovum size decreased in cold climates and at higher latitudes. Clutch size did not vary with climate or latitude, but reproductive effort (clutch size:female size) did, suggesting selection for a life-history traits that favors maximizing propagule number over propagule size in cold climates. With accelerating climate change that will expose populations to novel environmental conditions, it is important to identify the limits of adaptation, which can be informed by greater understanding of variation in life-history traits.

  18. Beyond the ‘dyad’: a qualitative re-evaluation of the changing clinical consultation

    Science.gov (United States)

    Swinglehurst, Deborah; Roberts, Celia; Li, Shuangyu; Weber, Orest; Singy, Pascal

    2014-01-01

    Objective To identify characteristics of consultations that do not conform to the traditionally understood communication ‘dyad’, in order to highlight implications for medical education and develop a reflective ‘toolkit’ for use by medical practitioners and educators in the analysis of consultations. Design A series of interdisciplinary research workshops spanning 12 months explored the social impact of globalisation and computerisation on the clinical consultation, focusing specifically on contemporary challenges to the clinician–patient dyad. Researchers presented detailed case studies of consultations, taken from their recent research projects. Drawing on concepts from applied sociolinguistics, further analysis of selected case studies prompted the identification of key emergent themes. Setting University departments in the UK and Switzerland. Participants Six researchers with backgrounds in medicine, applied linguistics, sociolinguistics and medical education. One workshop was also attended by PhD students conducting research on healthcare interactions. Results The contemporary consultation is characterised by a multiplicity of voices. Incorporation of additional voices in the consultation creates new forms of order (and disorder) in the interaction. The roles ‘clinician’ and ‘patient’ are blurred as they become increasingly distributed between different participants. These new consultation arrangements make new demands on clinicians, which lie beyond the scope of most educational programmes for clinical communication. Conclusions The consultation is changing. Traditional consultation models that assume a ‘dyadic’ consultation do not adequately incorporate the realities of many contemporary consultations. A paradox emerges between the need to manage consultations in a ‘super-diverse’ multilingual society, while also attending to increasing requirements for standardised protocol-driven approaches to care prompted by computer use. The tension between standardisation and flexibility requires addressing in educational contexts. Drawing on concepts from applied sociolinguistics and the findings of these research observations, the authors offer a reflective ‘toolkit’ of questions to ask of the consultation in the context of enquiry-based learning. PMID:25270858

  19. A Model of Re-Evaluating International Partnerships in Universities: A UK Example

    Science.gov (United States)

    Ayoubi, Rami M.

    2013-01-01

    International cooperation and partnerships became an important asset for UK universities, where in order to facilitate such international cooperation, selecting partners and arranging partnerships are considered as major organizational steps towards the success of the partnership itself. This study aims at investigating the organizational process…

  20. Seismic re-evaluation and upgrading of Bohunice V1 NPP

    International Nuclear Information System (INIS)

    Bohunice V1 in Slovakia is a two unit WWER 440/230 whose units went into commercial operation in 1979 and 1981 respectively. The plant was not initially designed for seismic loading. Later geotechnical studies concluded that the site seismic hazard should be defined as an earthquake of MSK 8 intensity. This relates to approximately 0.25 g peak ground acceleration in the free field at the site. Some early reconstruction to strengthen the plant against earthquakes was done in the early 1990s but did not include all safety significant structures and equipment. In 1996, EBO, the plant operator, entered into a contract with consortium REKON, a Siemens and VUJE joint venture, for a major reconstruction program to update all safety systems required for a safe shutdown, to improve integrity of confinement and assure spent fuel cooling. This reconstruction project includes verification of seismic adequacy of all safety related structures and equipment in the REKON scope which is not being replaced by new construction. Siemens and EQE International are jointly conducting the seismic verification and required upgrading for the existing structures and equipment. Criteria for the verification and upgrading were developed for the project utilizing Technical Guidelines provided by IAEA, Reference 1, and linking them with international and local codes and standards and specific methodologies developed for similar projects in the US and Western Europe. The criteria are briefly discussed herein and are summarized in a companion paper, Reference 4. Because of the major improvements being implemented in safety systems, much of the essential safety related equipment is being directly replaced or completely new systems are being constructed that supersede existing ones. Consequently, a significant amount of the equipment that would normally require seismic adequacy verification is deleted from the verification scope (see Table 4). The reconstruction project will continue through 1999. This paper summarizes the progress to date in seismic adequacy verification of existing structures and equipment which will remain as essential elements of the plant safety systems. (author)

  1. A re-examination and re-evaluation of salamander orbital glands.

    Science.gov (United States)

    Rehorek, Susan J; Grand-Pierre, Alix E; Cummings, Joshua R; Jewell, Bridgette; Constantine, Julieanne; Hillenius, W Jaap

    2013-11-01

    The amphibian integument contains numerous multicellular glands. Although two of these, the nasolabial and orbital glands and the associated nasolacrimal duct (NLD), have historically received considerable attention, interpretation of the original observations can be problematic in the context of current literature. Salamanders, in particular, are frequently regarded as at least indicative of aspects of the morphology of the common ancestor to all extant tetrapods; hence, an understanding of these glands in salamanders might prove to be informative about their evolution. For this study, the orbitonasal region of salamanders from three families was histologically examined. Three themes emerged: (1) examination of the effect of phylogeny on the nasolabial gland and NLD revealed a combination of features that may be unique to plethodontid salamanders, and may be correlated to their nose-tapping behavior by which substances are moved into the vomeronasal organ; (2) ecology appears to impact the relative development of the orbital glands, but not necessarily the nasolabial gland, with smaller glands being present in the aquatic species; (3) the nomenclature of the salamander orbital gland remains problematic, especially in light of comparative studies, as several alternate possibilities are viable. From this nomenclatural conundrum, however, it could be concluded that there may be a global pattern in the location of tetrapod orbital gland development. Molecular questions in terms of ontogeny and genetic homology affect the nature of the debate on orbital gland nomenclature. These observations suggest that rather than reflecting an ancestral condition, salamanders may instead represent a case of specialized, convergent evolution. PMID:24106029

  2. Nasopalatine ducts and flehmen behavior in the mandrill: reevaluating olfactory communication in Old World primates.

    Science.gov (United States)

    Charpentier, Marie J E; Mboumba, Sylvère; Ditsoga, Claude; Drea, Christine M

    2013-07-01

    Compared to other modes of communication, chemical signaling between conspecifics generally has been overlooked in Old World primates, despite the presence in this group of secretory glands and scent-marking behavior, as well as the confirmed production and perception of olfactory signals. In other mammalian species, flehmen is a behavior thought to transport primarily nonvolatile, aqueous-soluble odorants via specialized ducts to the vomeronasal organ (VNO). By contrast, Old World primates are traditionally thought to lack a functional VNO, relying instead on the main olfactory system to process volatile odorants from their environment. Here, in the mandrill (Mandrillus sphinx), we document unusual morphological and behavioral traits that typically are associated with the uptake of conspecific chemical cues for processing by an accessory olfactory system. Notably, we confirmed that both sexes possess open nasopalatine ducts and, in response to the presentation of conspecific odorants, we found that both sexes showed stereotyped behavior consistent with the flehmen response. If, as in other species, flehmen in the mandrill serves to mediate social or reproductive information, we expected its occurrence to vary with characteristics of either the signaler or receiver. Flehmen, particularly in a given male, occurred most often in response to odorants derived from male, as opposed to female, conspecifics. Moreover, odorants derived during the breeding season elicited more flehmen responses than did odorants collected during the birthing season. Lastly, odorants from reproductively cycling females also elicited more responses than did odorants from contracepted females. Although confirming a link between the nasopalatine ducts, flehmen behavior, and olfactory processing in mandrills would require further study, our observations provide new information to suggest anatomical variability within Old World primates, calling further attention to the underappreciated role of chemical communication in this lineage. PMID:23526642

  3. Empirical relationship between inlet cross-sectional area and tidal prism: A re-evaluation

    NARCIS (Netherlands)

    Stive, M.J.F.; Ji, L.; Brouwer, R.L.; Van de Kreeke, J.; Ranasinghe, R.W.M.R.J.B.

    2010-01-01

    The well-known empirical relationship between the equilibrium cross-sectional area of tidal inlet entrances (A) and the tidal prism (P), first developed by O’Brien (1931), has been extensively reviewed. Our theoretical investigations indicate that a unique A-P relationship should only be expected fo

  4. Reevaluation of 1999 Health-Based Environmental Screening Levels (HBESLs) for Chemical Warfare Agents

    Energy Technology Data Exchange (ETDEWEB)

    Watson, Annetta Paule [ORNL; Dolislager, Fredrick G [ORNL

    2007-05-01

    This report evaluates whether new information and updated scientific models require that changes be made to previously published health-based environmental soil screening levels (HBESLs) and associated environmental fate/breakdown information for chemical warfare agents (USACHPPM 1999). Specifically, the present evaluation describes and compares changes that have been made since 1999 to U.S. Environmental Protection Agency (EPA) risk assessment models, EPA exposure assumptions, as well as to specific chemical warfare agent parameters (e.g., toxicity values). Comparison was made between screening value estimates recalculated with current assumptions and earlier health-based environmental screening levels presented in 1999. The chemical warfare agents evaluated include the G-series and VX nerve agents and the vesicants sulfur mustard (agent HD) and Lewisite (agent L). In addition, key degradation products of these agents were also evaluated. Study findings indicate that the combined effect of updates and/or changes to EPA risk models, EPA default exposure parameters, and certain chemical warfare agent toxicity criteria does not result in significant alteration to the USACHPPM (1999) health-based environmental screening level estimates for the G-series and VX nerve agents or the vesicant agents HD and L. Given that EPA's final position on separate Tier 1 screening levels for indoor and outdoor worker screening assessments has not yet been released as of May 2007, the study authors find that the 1999 screening level estimates (see Table ES.1) are still appropriate and protective for screening residential as well as nonresidential sites. As such, risk management decisions made on the basis of USACHPPM (1999) recommendations do not require reconsideration. While the 1999 HBESL values are appropriate for continued use as general screening criteria, the updated '2007' estimates (presented below) that follow the new EPA protocols currently under development are also protective. When EPA finalizes and documents a position on the matter of indoor and outdoor worker screening assessments, site-specific risk assessments should make use of modified models and criteria. Screening values such as those presented in this report may be used to assess soil or other porous media to determine whether chemical warfare agent contamination is present as part of initial site investigations (whether due to intentional or accidental releases) and to determine whether weather/decontamination has adequately mitigated the presence of agent residual to below levels of concern. However, despite the availability of scientifically supported health-based criteria, there are significant resources needs that should be considered during sample planning. In particular, few analytical laboratories are likely to be able to meet these screening levels. Analyses will take time and usually have limited confidence at these concentrations. Therefore, and particularly for the more volatile agents, soil/destructive samples of porous media should be limited and instead enhanced with headspace monitoring and presence-absence wipe sampling.

  5. A reevaluation of the key factors that influence tomato fruit softening and integrity

    OpenAIRE

    Saladie, M.; Matas, A; Isaacson, T.; Jenks, M.; Goodwin, S.; Niklas, K.; Xiaolin, R.; Labavitch, J.; Shackel, K.; Fernie, A.; Lytovchenko, A.; O'Neill, M.; Watkins, C.; Rose, J.

    2007-01-01

    The softening of fleshy fruits, such as tomato (Solanum lycopersicum), during ripening is generally reported to result principally from disassembly of the primary cell wall and middle lamella. However, unsuccessful attempts to prolong fruit firmness by suppressing the expression of a range of wall-modifying proteins in transgenic tomato fruits do not support such a simple model. 'Delayed Fruit Deterioration' (DFD) is a previously unreported tomato cultivar that provides a unique opportunity t...

  6. Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor

    NARCIS (Netherlands)

    Möller, Thomas; Bard, Frédérique; Bhattacharya, Anindya; Biber, Knut; Campbell, Brian; Dale, Elena; Eder, Claudia; Gan, Li; Garden, Gwenn A; Hughes, Zoë A; Pearse, Damien D; Staal, Roland G W; Wes, Paul D; Boddeke, Hendrikus W G M

    2016-01-01

    Minocycline, a second generation broad-spectrum antibiotic, has been frequently postulated to be a "microglia inhibitor." A considerable number of publications have used minocycline as a tool and concluded, after achieving a pharmacological effect, that the effect must be due to "inhibition" of micr

  7. Re-evaluation of the 23Mg(p,γ) 24Al reaction rate

    Institute of Scientific and Technical Information of China (English)

    Liu Hong-Lin; Liu Men-Quan; Lai Xiang-Jun; Luo Zhi-Quan

    2007-01-01

    Based on a new screening Coulomb model, this paper discusses the effect of electron screening on proton capture reaction of 23Mg. The derived result shows that, in some considerable range of stellar temperatures, the effect of electron screening on resonant reaction is prominent; on the non-resonant reaction the effect is obvious only in the low stellar temperatures. The reaction rates of 23Mg(p,γ)24Al would increase 15%-25% due to the fact that the electron screening are considered in typical temperature range of massive mass white dwarfs, and the results undoubtedly affect the nucleosynthesis of some heavier nuclei in massive mass white dwarfs.

  8. Reevaluation of the role of the polar groups of collagen in the platelet-collagen interaction.

    OpenAIRE

    Chesney, C M; Pifer, D. D.; Crofford, L. J.; Huch, K. M.

    1983-01-01

    Chemical modification of collagen is a tool for exploring the platelet-collagen interaction. Since collagen must polymerize prior to the initiation of platelet aggregation and secretion, modification must be shown to affect platelet-collagen interaction and not collagen-collagen interaction. To address this point, the authors carried out the following chemical modifications on soluble monomeric collagen and preformed fibrillar collagen in parallel: 1) N-and O-acetylation, 2) esterification of...

  9. Reevaluation of a Radiation Risk Coefficient Based on a Review of the DDREF of Radiation Exposure

    Energy Technology Data Exchange (ETDEWEB)

    Urabe, I.

    2004-07-01

    On the basis of the consideration of the dose rate effectiveness of radiation exposure a sigmoid curve was fitted to the solid cancer dose response by A-bomb survivors. Since the variation of the ERR of solid cancer mortality could be represented by the sigmoid function, the DDREF of 10 was obtained by using the ERR per Sv around the weighted dose of 0.9 Sv (inflection point of the sigmoid curve) and 0.1 Sv (dose limit per 5 year or emergency) of the curve fitted. Though this might be large than the present value, the DDREF obtained here could be supported by the results of the studies in experimental human cells and animals conducting over wide dose and dose rate range such as acute, protracted and chronic exposure, which gave dose rate effectiveness factors from about 1 to 10 or more. Furthermore, it was quite possible that the higher DDREF would be explained by the acquirement of abilities of reducing the effects by radiation exposures. Based on these discussion, it has become clear that applying the DDREF of 10 yields a nominal value of 1x 10''-2 Sv for the probability of induced fatal caner in a population. And the annual mortality risk of 1x10''-5/y corresponding to the exposure of 1 mSv/y, which was on the order of the external annual background doses, was considered to be reasonable because it was well known that incidences below the risk of 1x10''-5/y were the events that the people did not show much concern about protective actions for mitigating the detriment in the society. (Author) 15 refs.

  10. Re-evaluating neonatal-age models for ungulates: does model choice affect survival estimates?

    Directory of Open Access Journals (Sweden)

    Troy W Grovenburg

    Full Text Available New-hoof growth is regarded as the most reliable metric for predicting age of newborn ungulates, but variation in estimated age among hoof-growth equations that have been developed may affect estimates of survival in staggered-entry models. We used known-age newborns to evaluate variation in age estimates among existing hoof-growth equations and to determine the consequences of that variation on survival estimates. During 2001-2009, we captured and radiocollared 174 newborn (≤24-hrs old ungulates: 76 white-tailed deer (Odocoileus virginianus in Minnesota and South Dakota, 61 mule deer (O. hemionus in California, and 37 pronghorn (Antilocapra americana in South Dakota. Estimated age of known-age newborns differed among hoof-growth models and varied by >15 days for white-tailed deer, >20 days for mule deer, and >10 days for pronghorn. Accuracy (i.e., the proportion of neonates assigned to the correct age in aging newborns using published equations ranged from 0.0% to 39.4% in white-tailed deer, 0.0% to 3.3% in mule deer, and was 0.0% for pronghorns. Results of survival modeling indicated that variability in estimates of age-at-capture affected short-term estimates of survival (i.e., 30 days for white-tailed deer and mule deer, and survival estimates over a longer time frame (i.e., 120 days for mule deer. Conversely, survival estimates for pronghorn were not affected by estimates of age. Our analyses indicate that modeling survival in daily intervals is too fine a temporal scale when age-at-capture is unknown given the potential inaccuracies among equations used to estimate age of neonates. Instead, weekly survival intervals are more appropriate because most models accurately predicted ages within 1 week of the known age. Variation among results of neonatal-age models on short- and long-term estimates of survival for known-age young emphasizes the importance of selecting an appropriate hoof-growth equation and appropriately defining intervals (i.e., weekly versus daily for estimating survival.

  11. Re-evaluating high-latitude warming in the Pliocene Nordic Seas

    Science.gov (United States)

    Hill, Daniel; Smith, Yvonne; Dolan, Aisling

    2016-04-01

    The Pliocene warm period was generally been seen as stable warm climate with global temperatures of 2-3K above pre-industrial and significant polar amplification. Northern Hemisphere ice has been reconstructed to be restricted to the high altitude areas of Greenland and global reconstructions of sea surface temperatures show an especially strong warming in the Nordic Seas, most often attributed to increased ocean heat transport in the North Atlantic Ocean. Here we present climate model results that show that the strongest warming recorded in the Nordic Seas and Arctic is forced by changes in orbital forcing and palaeogeographic changes. Of particular importance is the presence of a sub-aerial landmass in the Barents Sea region, which has subsequently been eroded by Pleistocene glaciation. While climate models can produce strong warming signals in the Nordic Seas, a new iceberg modelling study showing that through much of the Pliocene the conditions in the Nordic Seas were suitable for the presence of significant quantities of icebergs. The locations of IRD records also raises the possibility of significant glaciations in places previously considered to be ice free in the Pliocene.

  12. Re-evaluation of the LHC potential for the measurement of mW

    International Nuclear Information System (INIS)

    We present a study of the LHC sensitivity to the W boson mass based on simulation studies. We find that both experimental and phenomenological sources of systematic uncertainties can be strongly constrained with Z measurements: the lineshape, dσZ/dm, is robustly predicted, and its analysis provides an accurate measurement of the detector resolution and absolute scale, while the differential cross-section analysis, d2σZ/dydpT, absorbs the strong interaction uncertainties. A sensitivity δmW∝7 MeV for each decay channel (W→eν,W→μν), and for an integrated luminosity of 10fb-1, appears as a reasonable goal. (orig.)

  13. Re-evaluation of the LHC potential for the measurement of m{sub W}

    Energy Technology Data Exchange (ETDEWEB)

    Besson, Nathalie; Boonekamp, Maarten [CEA, IRFU, SPP, DSM Saclay, Gif sur Yvette (France); Klinkby, Esben; Mehlhase, Sascha [Niels Bohr Institute, Copenhagen (Denmark); Petersen, Troels [Niels Bohr Institute, Copenhagen (Denmark); European Organization for Nuclear Research CERN, Geneva 23 (Switzerland)

    2008-10-15

    We present a study of the LHC sensitivity to the W boson mass based on simulation studies. We find that both experimental and phenomenological sources of systematic uncertainties can be strongly constrained with Z measurements: the lineshape, d{sigma}{sub Z}/dm, is robustly predicted, and its analysis provides an accurate measurement of the detector resolution and absolute scale, while the differential cross-section analysis, d{sup 2}{sigma}{sub Z}/dydp{sub T}, absorbs the strong interaction uncertainties. A sensitivity {delta}m{sub W}{proportional_to}7 MeV for each decay channel (W{yields}e{nu},W{yields}{mu}{nu}), and for an integrated luminosity of 10fb{sup -1}, appears as a reasonable goal. (orig.)

  14. Interrupting, patronizing and silencing in the series Teen Mom 2:re-evaluating the stereotypes

    OpenAIRE

    Sirén, T. (Teppo)

    2016-01-01

    Today’s western society sees women as powerless and incapable and men as dominant leaders in any given situation. These stereotypes of men and women are often reflected as expectations of how men and women should behave and carry themselves. Women are expected to stay quiet and men are expected to take charge regardless of the situation at hand. These expectations further prevent opportunities for both men and women in working life, for example. They also cloud people’s ability and willingnes...

  15. Re-evaluation of the function of the male specific lethal complex in Drosophila

    Institute of Scientific and Technical Information of China (English)

    James Birchler; Lin Sun; Harvey Fernandez; Ryan Donohue; Weiwu Xie; Abhijit Sanyal

    2011-01-01

    A set of proteins and noncoding RNAs,referred to as the male specific lethal (MSL) complex,is present on the male X chromosome in Drosophila and has been postulated to be responsible for dosage compensation of this chromosome - the up-regulation of its expression to be equal to that of two X chromosomes in females.This hypothesis is evaluated in view of lesser known aspects of dosage compensation such as the fact that metafemales with three X chromosomes also have equal expression to normal females,which would require a down-regulation of each gene copy.Moreover,when this complex is ectopically expressed in females or specifically targeted to a reporter in males,there is no increase in expression of the genes or targets with which it is associated.These observations are not consistent with the hypothesis that the MSL complex conditions dosage compensation.A synthesis is described that can account for these observations.

  16. Re-evaluation of cystic echinococcosis with molecular differentiation of causative species

    Science.gov (United States)

    Human cystic echinococcosis (CE) has been conceived to be caused predominantly by Echinococcus granulosus sensu stricto (the dog-sheep strain). Recent molecular approaches on CE, however, have revealed that human cases are also commonly caused by another species, Echinococcus canadensis. All indices...

  17. Evaluation and re-evaluation of genetic radiation hazards in man

    International Nuclear Information System (INIS)

    The arm number hypothesis proposed by Brewen and colleagues in 1973 has been examined in the light of information thus far available from mammalian studies. In experiments with peripheral blood lymphocytes (radiation in vitro), a linear relationship between dicentric yield and the effective chromosome arm number of the species was obtained in the mouse, Chinese hamster, goat, sheep, pig, wallaby and man. However, the data are not consistent with such a relationship in several primate species (marmoset, rhesus monkey, cynomolgus monkey, squirrel monkey and the slow loris), the cat and the dog. In the rabbit, the data are conflicting. In the mouse and the Chinese hamster the frequencies of reciprocal translocations recorded in spermatocytes descended from irradiated spermatogonia are in line with the expectation based on the arm number hypothesis, whereas in the golden hamster, rabbit and the rhesus they are not. In man and the marmoset, the limited data are not inconsistent with a 2-fold higher sensitivity of these species relative to the mouse although they do not rule out a difference as high as 4-fold. In the guinea-pig, the situation is unclear. New data on the transmission of reciprocal translocations in mice suggest that the frequency in the F1 progeny may be close to one-quarter of that recorded in the spermatocytes of the irradiated fathers (spermatogonial irradiation) at an exposure level of 150 R, whereas at higher exposures, the reduction factor is about one-eighth, the latter being in line with the earlier finding. All these results taken together suggest that inter-specific extrapolation from the radiosensitivity of somatic cells (to dicentric induction) to that of germ cells (to translocation induction) is fraught with uncertainty at present. Certain aspects that need to be studied in more detail in the context of induced chromosome aberrations are discussed

  18. Re-evaluating gadolinium(III) texaphyrin as a radiosensitizing agent.

    Science.gov (United States)

    Bernhard, E J; Mitchell, J B; Deen, D; Cardell, M; Rosenthal, D I; Brown, J M

    2000-01-01

    Gadolinium(III) texaphyrin (Gd-tex) was recently proposed as a radiosensitizing agent that combines preferential tumor uptake with detection of drug localization by magnetic resonance imaging (S. W. Young et al., Proc. Natl. Acad. Sci. USA, 93: 6610-6615, 1996). In view of the initial report on this compound, four radiobiology laboratories undertook independent efforts to further study radiosensitization by Gd-tex. In addition to repeating the previously reported studies on Gd-tex in HT-29 cells, we tested five other human tumor cell lines (U-87 MG, U251-NCI, SW480, A549, and MCF-7). These studies included a Gd-tex treatment period of 24 h before irradiation (as in the original publication), with concentrations of Gd-tex ranging from 20-500 microM. In neither the HT-29 cells nor any of the other five human cell lines did we see radiation sensitization by Gd-tex. Two cell lines (MCF-7 and U-87 MG) were further tested for radiosensitization by Gd-tex under hypoxic conditions. No radiosensitization was observed in either case. Finally, the radiation response of two tumor lines were assessed in vivo. Neither HT-29 xenografts in severe combined immunodeficient (SCID) mice nor RIF-1 tumors growing in C3H mice demonstrated radiosensitization after Gd-tex treatment before single or fractionated doses of radiation. Our results raise questions about the efficacy of Gd-tex as a radiosensitizing agent. PMID:10646858

  19. Re-evaluation of sugarcane borer (Lepidoptera: Crambidae) bioeconomics in Louisiana

    Science.gov (United States)

    The sugarcane borer, Diatraea saccharalis (F.) (Lepidoptera: Crambidae), is the key insect pest of sugarcane, Saccharum spp., grown in Louisiana. For more than 40 years Louisiana sugarcane farmers have used a value of 10% internodes bored at harvest as the Economic Damage level (ED) because damage l...

  20. Re-evaluation and Re-commendation of Neutron Induced Data of 197Au

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The evaluation of neutron-induced data of 197Au with energy range from 10-5 eV to 20 MeV wascarried out. Based on the available measured data, the code APMN is used to get the neutron opticalpotential with energy region from 5 keV to 20 MeV based on the available measured data, such as totalcross section, non-elastic scattering cross sections and elastic angular distributions. The parameters for

  1. Stories and story telling in first-levellanguage learning: a re-evaluation

    Directory of Open Access Journals (Sweden)

    Robert W. Blair

    2013-02-01

    Full Text Available This paper proposes that in the midst of all our theories on language teaching and language learning, we might have overlooked an age-old tool that has always been at the disposal of mankind; the telling of stories. Attention is drawn to how some have found in stories and story telling a driving force of natural language acquisition, a key that can unlock the intuitive faculties ofthe mind. A case is being made out for the re-instalment of stories and associated activities as a means of real, heart-felt functional communication in a foreign language, rather than through a direct assault on the structure of the language itself. Met hierdie artikel word daar voorgestel dat daar opnuut gekyk moet word na 'n hulpmiddel wat so oud is as die mensheid self en wat nog altyd tot ons beskikking was, naamlik stories en die vertel daarvan. Die aandag word daarop gevestig dat daar persone is wat in stories en die verbale oordrag daarvan 'n stukrag ontdek het tot natuurlike taalvaardigheid, 'n sleutel tot die intultiewe breinfunksies. Daar word 'n saak uitgemaak vir die terugkeer na stories en gepaardgaande aktiwiteite as middel tot 'n egte, diep deurleefde en funksionele wyse van kommunikasie in 'n vreemde taal, eerder as 'n direkte aanslag op die taalstruktuur self.

  2. Reevaluating the conceptual framework for applied research on host-plant resistance

    Institute of Scientific and Technical Information of China (English)

    Michael J.Stout

    2013-01-01

    Applied research on host-plant resistance to arthropod pests has been guided over the past 60 years by a framework originally developed by Reginald Painter in his 1951 book,Insect Resistance in Crop Plants.Painter divided the "phenomena" of resistance into three "mechanisms," nonpreference (later renamed antixenosis),antibiosis,and tolerance.The weaknesses of this framework are discussed.In particular,this trichotomous framework does not encompass all known mechanisms of resistance,and the antixenosis and antibiosis categories are ambiguous and inseparable in practice.These features have perhaps led to a simplistic approach to understanding arthropod resistance in crop plants.A dichotomous scheme is proposed as a replacement,with a major division between resistance (plant traits that limit injury to the plant) and tolerance (plant traits that reduce amount of yield loss per unit injury),and the resistance category subdivided into constitutive/inducible and direct/indirect subcategories.The most important benefits of adopting this dichotomous scheme are to more closely align the basic and applied literatures on plant resistance and to encourage a more mechanistic approach to studying plant resistance in crop plants.A more mechanistic approach will be needed to develop novel approaches for integrating plant resistance into pest management programs.

  3. Vike-Freiberga calls on Russia to re-evaluate its history / Aaron Eglitis

    Index Scriptorium Estoniae

    Eglitis, Aaron

    2003-01-01

    Rahvusvahelisel holokausti uurimise konverentsil avaldas Läti president Vaira Vike-Freiberga kahetsust, et kuna Venemaa ei soovi tunnistada Läti okupeerimist Nõukogude Liidu poolt 1940. aasta juunis, tekitab see probleeme Läti-Vene suhetes

  4. Reevaluation of Mineral aerosol radiative forcings suggests a better agreement with satellite and AERONET data

    Directory of Open Access Journals (Sweden)

    Y. Balkanski

    2007-01-01

    Full Text Available Modelling studies and satellite retrievals do not agree on the amplitude and/or sign of the direct radiative perturbation from dust. Modelling studies have systematically overpredicted mineral dust absorption compared to estimates based upon satellite retrievals. In this paper we first point out the source of this discrepancy, which originates from the shortwave refractive index of dust used in models. The imaginary part of the refractive index retrieved from AERONET over the range 300 to 700 nm is 3 to 6 times smaller than that used previously to model dust. We attempt to constrain these refractive indices using a mineralogical database and varying the abundances of iron oxides (the main absorber in the visible. We first consider the optically active mineral constituents of dust and compute the refractive indices from internal and external mixtures of minerals with relative amounts encountered in parent soils. We then compute the radiative perturbation due to mineral aerosols for internally and externally mixed minerals for 3 different hematite contents, 0.9%, 1.5% and 2.7% by volume. These constant amounts of hematite allow bracketing the influence of dust aerosol when it is respectively an inefficient, standard and a very efficient absorber. These values represent low, central and high content of iron oxides in dust determined from the mineralogical database. Linke et al. (2006 determined independently that iron-oxides represent 1.0 to 2.5% by volume using x-Ray fluorescence on 4 different samples collected over Morocco and Egypt. Based upon values of the refractive index retrieved from AERONET, we show that the best agreement between 440 and 1020 nm occurs for mineral dust internally mixed with 1.5% volume weighted hematite. This representation of mineral dust allows us to compute, using a general circulation model, a new global estimate of mineral dust perturbation between –0.47 and –0.24 Wm−2 at the top of the atmosphere, and between –0.81 and –1.13 Wm−2 at the surface for both shortwave and longwave wavelengths. The anthropogenic dust fraction is thought to account for between 10 and 50% of the total dust load present in the atmosphere. We estimate a top of the atmosphere forcing between –0.03 and –0.25 Wm−2, which is markedly different that the IPCC range of –0.6 to +0.4 Wm−2 (IPCC, 2001. The 24-h average atmospheric heating by mineral dust during summer over the tropical Atlantic region (15° N–25° N; 45° W–15° W is in the range +22 to +32 Wm−2 τ−1 which compares well with the 30±4 Wm−2 τ−1 measured by Li et al. (2004 over that same region. The refractive indices from Patterson et al. (1977 and from Volz (1973 overestimate by a factor of 2 the energy absorbed in the column during summer over the same region. This discrepancy is due to too large absorption in the visible but we could not determine if this is linked to the sample studied by Patterson et al. (1997 or to the method used in determining the refractive index.

  5. Reevaluation of Stratospheric Ozone Trends From SAGE II Data Using a Simultaneous Temporal and Spatial Analysis

    Science.gov (United States)

    Damadeo, R. P.; Zawodny, J. M.; Thomason, L. W.

    2014-01-01

    This paper details a new method of regression for sparsely sampled data sets for use with time-series analysis, in particular the Stratospheric Aerosol and Gas Experiment (SAGE) II ozone data set. Non-uniform spatial, temporal, and diurnal sampling present in the data set result in biased values for the long-term trend if not accounted for. This new method is performed close to the native resolution of measurements and is a simultaneous temporal and spatial analysis that accounts for potential diurnal ozone variation. Results show biases, introduced by the way data is prepared for use with traditional methods, can be as high as 10%. Derived long-term changes show declines in ozone similar to other studies but very different trends in the presumed recovery period, with differences up to 2% per decade. The regression model allows for a variable turnaround time and reveals a hemispheric asymmetry in derived trends in the middle to upper stratosphere. Similar methodology is also applied to SAGE II aerosol optical depth data to create a new volcanic proxy that covers the SAGE II mission period. Ultimately this technique may be extensible towards the inclusion of multiple data sets without the need for homogenization.

  6. Phylogenetic and morphological re-evaluation of the Botryosphaeria species causing diseases of Mangifera indica

    NARCIS (Netherlands)

    Slippers, B.; Johnson, G.I.; Crous, P.W.; Coutinho, T.A.; Wingfield, B.D.; Wingfield, M.J.

    2005-01-01

    Species of Botryosphaeria are among the most serious pathogens that affect mango trees and fruit. Several species occur on mangoes, and these are identified mainly on the morpholopy of the anamorphs. Common taxa include Dothiorella dominicana, D. mangiferae (= Natrassia mangiferae), D. aromatica and

  7. Re-evaluating the NO 2 hotspot over the South African Highveld

    Directory of Open Access Journals (Sweden)

    Alexandra S.M. Lourens

    2012-10-01

    Full Text Available Globally, numerous pollution hotspots have been identified using satellite-based instruments. One of these hotspots is the prominent NO2hotspot over the South African Highveld. The tropospheric NO2column density of this area is comparable to that observed for central and northern Europe, eastern North America and south-east Asia. The most well-known pollution source in this area is a large array of coal-fired power stations. Upon closer inspection, long-term means of satellite observations also show a smaller area, approximately 100 km west of the Highveld hotspot, with a seemingly less substantial NO2column density. This area correlates with the geographical location of the Johannesburg–Pretoria conurbation or megacity, one of the 40 largest metropolitan areas in the world. Ground-based measurements indicate that NO2concentrations in the megacity have diurnal peaks in the early morning and late afternoon, which coincide with peak traffic hours and domestic combustion. During these times, NO2concentrations in the megacity are higher than those in the Highveld hotspot. These diurnal NO2 peaks in the megacity have generally been overlooked by satellite observations because the satellites have fixed local overpass times that do not coincide with these peak periods. Consequently, the importance of NO2 over the megacity has been underestimated. We examined the diurnal cycles of NO2 ground-based measurements for the two areas – the megacity and the Highveld hotspot – and compared them with the satellite-based NO2 observations. Results show that the Highveld hotspot is accompanied by a second hotspot over the megacity, which is of significance for the more than 10 million people living in this megacity.

  8. Psychometric Reevaluation of Parental Press for Academic Achievement and Postsecondary Planning Scale

    Science.gov (United States)

    Bates, Samantha; Ball, Annahita; Wilks, Scott

    2016-01-01

    Objective: Psychometric details of the Parental Press for Academic Achievement and Postsecondary Planning Scale (PPS), developed by Chicago Consortium of Chicago School Research, are scarce. The purpose of this study was to reexamine the properties of this 7-item measure. Method: The study utilized cross-sectional, self-reported data from 100…

  9. Reevaluating the first and the second dividends of environmental tax reforms

    Energy Technology Data Exchange (ETDEWEB)

    Gimenez, Eduardo L. [Departamento de Fundamentos da Analise Economica e Historia e Institucions Economicas and rede, Universidade de Vigo (Spain); Rodriguez, Miguel [Departamento de Economia Aplicada and rede, Universidade de Vigo (Spain)

    2010-11-15

    There is increasing global interest in market-based climate change policies following the last elections in the United States. In this context an Exxon Mobil chief executive came out in favour of a carbon tax. This paper is concerned with the welfare analysis of Environmental Tax Reforms (ETR), and takes up the claims for the need of an unambiguous and operative definition of the double dividend both for empirical purposes and political advisement. In this paper, we contest the usual definition of the second dividend and its assimilation to an 'efficiency dividend'. We propose alternative definitions by suggesting a different splitting of the total welfare variation between the first and the second dividend in order to isolate the efficiency effects of the ETR. The new definitions become clearly understandable and easy for economic and policy interpretation. Concepts like 'weak' and 'strong' double dividend turn out to be unnecessary. Finally, we analyze ETR for the US economy to illustrate the advantages of the proposed definitions for policy implementation. (author)

  10. Reevaluation of spin-dependent WIMP-proton interactions as an explanation of the DAMA data

    Energy Technology Data Exchange (ETDEWEB)

    Nobile, Eugenio Del; Gelmini, Graciela B.; Georgescu, Andreea; Huh, Ji-Haeng [Department of Physics and Astronomy, UCLA,475 Portola Plaza, Los Angeles, CA 90095 (United States)

    2015-08-25

    We reexamine the interpretation of the annual modulation signal observed by the DAMA experiment as due to WIMPs with a spin-dependent coupling mostly to protons. We consider both axial-vector and pseudo-scalar couplings, and elastic as well as endothermic and exothermic inelastic scattering. We conclude that the DAMA signal is in strong tension with null results of other direct detection experiments, particularly PICASSO and KIMS.

  11. Re-evaluation of neutron nuclear data for 129I and 143Nd

    International Nuclear Information System (INIS)

    The evaluated nuclear data for 129I and 143Nd stored in JENDL-3.3 were investigated comparing with other evaluated data and experimental data. New experimental data were available especially for the capture cross sections of both nuclides. The parameters used in theoretical calculations were modified so as to reproduce those experimental data. The statistical model calculation was performed using the revised parameters. The resonance parameters were also revised so that the cross sections measured in the thermal energy region were reproduced well. The present results were compiled in the ENDF-6 format. (author)

  12. Reevaluating the Role of Saharan Air Layer in Atlantic Tropical Cyclogenesis and Evolution

    Science.gov (United States)

    Braun, Scott A.

    2010-01-01

    The existence of the Saharan air layer (SAL), a layer of warm, dry, dusty air that frequently moves westward off of the Saharan desert of Africa and over the tropical Atlantic Ocean, has long been appreciated. As air moves over the desert, it is strongly heated from below, producing a very hot air mass at low levels. Because there is no moisture source over the Sahara, the rise in temperature causes a sharp drop in relative humidity, thus drying the air. In addition, the warm air produces a very strong jet of easterly flow in the middle troposphere called the African easterly jet that is thought to play a critical role in hurricane formation. In recent years, there has been an increased focus on the impact that the SAL has on the formation and evolution of hurricanes in the Atlantic. However, the nature of its impact remains unclear, with some researchers arguing that the SAL amplifies hurricane development and with others arguing that it inhibits it. The argument for positively influencing hurricane development is based upon the fact that the African easterly jet provides an energy source for the waves that eventually form hurricanes and that it leads to rising motion south of the jet that favors the development of deep thunderstorm clouds. The potential negative impacts of the SAL include 1) low-level vertical wind shear associated with the African easterly jet; 2) warm SAL air aloft, which increases thermodynamic stability and suppresses cloud development; and 3) dry air, which produces cold downdrafts in precipitating regions, thereby removing energy needed for storm development. As part of this recent focus on the SAL and hurricanes (which motivated a 2006 NASA field experiment), there has been little emphasis on the SAL s potential positive influences and almost complete emphasis on its possible negative influences, almost to the point of claims that the SAL is the major suppressing influence on hurricanes in the Atlantic. In this study, multiple NASA satellite data sets (TRMM, MODIS, CALIPSO, and AIRS/AMSU) and National Centers for Environmental Prediction global analyses are used to see if the proposed negative influences deserve all of the attention they have recently received. The results show that storms generally form on the southern side of the African jet, where favorable background rotation is high. The jet often helps to form the northern side of the storms and is typically stronger in storms that intensify than those that weaken, suggesting that jet-induced vertical wind shear is not a negative influence on developing storms. Warm SAL air is confined to regions north of the jet and generally does not impact the tropical cyclone precipitation south of the jet. A comparison of the environments of strongly strengthening storms and of weakening storms shows no differences in SAL structure, indicating that the SAL has little influence on whether storms weaken or intensify. The large-scale flow at upper levels above the SAL was found to be most important, with the environment of strengthening storms having very little vertical wind shear and also favoring more expansive outflow from the storm. The SAL is shown to occur in a large-scale environment that is already characteristically dry as a result of large-scale subsidence (sinking air motions). Strong surface heating and deep dry convective mixing enhance dryness at low levels, but moisten the air at midlevels. Therefore, mid-to-upper-level dryness is not a defining characteristic of the SAL, but is instead a signature of subsidence. As a result, we conclude that the SAL is not the major negative influence on hurricanes that recent studies have emphasized. It is just one of many possible influences and can be both positive and negative.

  13. A Case for Reevaluating Teacher's Role in Data-Driven Learning (DDL) of English Articles

    Institute of Scientific and Technical Information of China (English)

    ZHAO Juan

    2013-01-01

    A case study has been made to explore whether the teacher’s role in data-driven learning (DDL) can be minimized. The outcome shows that the teacher’s role in offering an explicit instruction may be indispensable and even central to the acquisi-tion of English articles.

  14. Reevaluation of antimicrobial and antioxidant activity of Thymus spp. extracts before and after encapsulation in liposomes.

    Science.gov (United States)

    Gortzi, Olga; Lalas, Stavros; Chinou, Ioanna; Tsaknis, John

    2006-12-01

    The antioxidant and antimicrobial activity of four Thymus species (boissieri, longicaulis, leucospermus, and ocheus) extracts were determined. Two methods (Rancimat and malondialdehyde by high-performance liquid chromatography) were used to measure the antioxidant action in comparison with common commercial antioxidants, including butylated hydroxytoluene and alpha-tocopherol. The extracts that presented high antioxidant activity were encapsulated in liposomes and their antioxidant action was again estimated. Thermal-oxidative decomposition of the samples (pure liposomes and encapsulating extracts) was studied using the differential scanning calorimetry method. The modification of the main transition temperature for the lipid mixture and the splitting of the calorimetric peak in the presence of the antioxidants were also demonstrated by differential scanning calorimetry. All extracts showed antioxidant and antimicrobial activities. Some extracts showed superior or equal antioxidant activity to alpha-tocopherol. When the extracts were encapsulated in liposomes, their antioxidant as well as antimicrobial activities proved to be superior from the same extracts in pure form. PMID:17186670

  15. Psychometric Reevaluation of the Women in Science Scale (WiSS)

    Science.gov (United States)

    Owen, Steven V.; Toepperwein, Mary Anne; Pruski, Linda A.; Blalock, Cheryl L.; Liu, Yan; Marshall, Carolyn E.; Lichtenstein, Michael J.

    2007-01-01

    The Women in Science Scale (WiSS) was first developed in 1984, and is still being used in contemporary studies, yet its psychometric properties have not been evaluated with current statistical methods. In this study, the WiSS was administered in its original 27-item form to 1,439 middle and high school students. Confirmatory factor analysis based…

  16. Strategies of vertebrate neurulation and a re-evaluation of teleost neural tube formation.

    Science.gov (United States)

    Lowery, Laura Anne; Sive, Hazel

    2004-10-01

    The vertebrate neural tube develops by two distinct mechanisms. Anteriorly, in the brain and future trunk (cervicothoracic) region, 'primary neurulation' occurs, where an epithelial sheet rolls or bends into a tube. Posteriorly, in the future lumbar and tail region, the neural tube forms by 'secondary neurulation', where a mesenchymal cell population condenses to form a solid rod that undergoes transformation to an epithelial tube. Teleost neurulation has been described as different from that of other vertebrates. This is principally because the teleost trunk neural tube initially forms a solid rod (the neural keel) that later develops a lumen. This process has also been termed secondary neurulation. However, this description is not accurate since the teleost neural tube derives from an epithelial sheet that folds. This best fits the description of primary neurulation. It has also been suggested that teleost neurulation is primitive, however, both primary and secondary neurulation are found in groups with a more ancient origin than the teleosts. The similarity between neurulation in teleosts and other vertebrates indicates that this group includes viable models (such as the zebrafish) for understanding human neural tube development.

  17. Re-evaluation of batoid pectoral morphology reveals novel patterns of diversity among major lineages.

    Science.gov (United States)

    Martinez, Christopher M; Rohlf, F James; Frisk, Michael G

    2016-04-01

    Batoids (Chondrichthyes: Batoidea) are a diverse group of cartilaginous fishes which comprise a monophyletic sister lineage to all neoselachians or modern sharks. All species in this group possess anteroposteriorly expanded-pectoral fins, giving them a unique disc-like body form. Reliance on pectoral fins for propulsion ranges from minimal (sawfish) to almost complete dependence (skates and rays). A recent study on the diversity of planform pectoral fin shape in batoids compared overall patterns of morphological variation within the group. However, inconsistent pectoral homology prevented the study from accurately representing relationships within and among major batoid taxa. With previous work in mind, we undertook an independent investigation of pectoral form in batoids and evaluated the implications of shape diversity on locomotion and lifestyle, particularly in the skates (Rajoidei) and rays (Myliobatoidei). We used geometric morphometrics with sliding semilandmarks to analyze pectoral fin outlines and also calculate fin aspect ratios (AR), a functional trait linked to locomotion. In agreement with previous work, our results indicated that much of the evolution of batoid pectoral shape has occurred along a morphological axis that is closely related to AR. For species where kinematic data were available, both shape and AR were associated with swimming mode. This work further revealed novel patterns of shape variation among batoids, including strong bimodality of shape in rays, an intermediate location of skate species in the morphospace between benthic/demersal and pelagic rays, and approximately parallel shape trajectories in the benthic/demersal rays and skates. Finally, manipulation of landmarks verified the need for a consistent and accurate definition of homology for the outcome and efficacy of analyses of pectoral form and function in batoids. PMID:26869186

  18. Bathymetric limits of chondrichthyans in the deep sea: A re-evaluation

    Science.gov (United States)

    Musick, J. A.; Cotton, C. F.

    2015-05-01

    Chondrichthyans are largely absent in abyssal (>3000 m) habitats in most regions of the world ocean and are uncommon below 2000 m. The deeper-living chondrichthyans include certain rajids, squaliforms and holocephalans. Several hypotheses have been erected to explain the absence of chondrichthyans from the abyss. These are mostly based on energetics: deep-sea food webs are impoverished due to their distance from primary production, and chondrichthyans, occupying the highest trophic levels, cannot be supported due to entropy among trophic levels. We examined this hypothesis by comparing trophic levels, calculated from dietary data, of deep-sea chondrichthyans with those of deep-sea teleosts. Chondrichthyans were mostly above trophic level 4, whereas all the teleosts examined were below that level. Both small and medium squaloids, as well as sharks and skates of large size, feed on fishes, cephalopods and scavenged prey, and thus occupy the highest trophic levels in bathydemersal fish communities. In addition, whereas teleosts and chondrichthyans both store lipids in their livers to support long periods of fasting, chondrichthyans must devote much of their liver lipids to maintain neutral buoyancy. Consequently teleosts with swim bladders are better adapted to survive in the abyss where food sources are sparse and unpredictable. The potential prey field for both chondrichthyans and teleosts declines in biomass and diversity with depth, but teleosts have more flexibility in their feeding mechanisms and food habits, and occupy abyssal trophic guilds for which chondrichthyans are ill adapted.

  19. Using genetic inference to re-evaluate the minimum longevity of the lemon shark Negaprion brevirostris.

    Science.gov (United States)

    Brooks, J L; Guttridge, T L; Franks, B R; Grubbs, R D; Chapman, D D; Gruber, S H; Dibattista, J D; Feldheim, K A

    2016-05-01

    A combination of mark-recapture and genetic sampling was used to extend the minimum longevity of an elasmobranch species and the life span estimate of the lemon shark Negaprion brevirostris was increased conservatively from 20·2 to 37 years. This increase in longevity means higher vulnerability and a longer recovery time from exploitation. PMID:27060882

  20. Rasch analysis of the Knee injury and Osteoarthritis Outcome Score (KOOS): a statistical re-evaluation

    DEFF Research Database (Denmark)

    Comins, J; Brodersen, J; Krogsgaard, M;

    2008-01-01

    The knee injury and Osteoarthritis Outcome Score (KOOS), based on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), is widely used to evaluate subjective outcome in anterior cruciate ligament (ACL) reconstructed patients. However, the validity of KOOS has not been assessed...... using Rasch analysis. The objective of this study was to evaluate the viability of KOOS as an outcome measure for ACL reconstruction using the partial credit Rasch model. Rasch analysis was applied to 200 KOOS questionnaires completed by patients consecutively tested 20 weeks after ACL reconstruction...... in KOOS extracted from WOMAC did not fulfill these criteria. While the content of KOOS appears to be relevant for knee patients, the psychometric measurement properties of KOOS are insufficient for use on patients 20 weeks subsequent to ACL reconstruction. A new knee measure targeted for these patients...

  1. The Relation between Life Satisfaction and the Material Situation: A Re-Evaluation Using Alternative Measures

    Science.gov (United States)

    Christoph, Bernhard

    2010-01-01

    Among the surprising results of research on the relation between a person's material circumstances and his or her subjective well-being was the finding that this relationship appears to be rather weak (throughout this paper the terms "(general) life satisfaction", "(subjective) satisfaction", "happiness" and "subjective well-being" will be used…

  2. A comparison of five commercial thromboplastins: ISI re-evaluation on an automated coagulometer.

    Science.gov (United States)

    Ford, K; McArdle, B; Kesteven, P J

    1995-03-01

    Five commercial rabbit brain thromboplastins were compared with an International Reference Preparation on an ACL coagulometer, using 90 patients stabilized on warfarin and 22 normal individuals. The prothrombin times were converted to INRs using the thromboplastin manufacturers' quoted ISI. The quoted ISIs were reassigned using orthogonal regression analysis and then used to recalculate INRs for patient and commercial INR control plasmas. This showed that the manufacturers' quoted ISIs and the INR control plasma results were inconsistent. With one thromboplastin the manufacturers quoted ISI changed from 1.17 to 1.05 whilst the control plasma results changed from an INR of 4.3 to an INR of 3.7 (manufacturer's INR, 3.3). In most routine laboratories ISI reassignment is not practical. We conclude that the availability of a reliable plasma calibrant is essential for the accurate calculation of INRs at a local level.

  3. Re-evaluation of Need for Bone Marrow Examination in Patients with Isolated Thrombocytopenia Contributors.

    Science.gov (United States)

    Purohit, Abhishek; Aggarwal, Mukul; Singh, Pawan Kumar; Mahapatra, Manoranjan; Seth, Tulika; Tyagi, Seema; Saxena, Renu; Pati, Hara P; Mishra, Pravas

    2016-06-01

    Diagnosis of immune thrombocytopenia (ITP) is based on clinical suspicion and normal peripheral smear except for thrombocytopenia. Bone marrow examination is carried out to rule out leukemia, myelodysplastic syndrome or aplastic anemia. However, in most cases, clinical diagnosis is not altered after the bone marrow reports. Hence, this present study was carried out to evaluate the justification for bone marrow examination in the setting of isolated thrombocytopenia. All patients presenting to the hematology OPD with isolated thrombocytopenia and suspected diagnosis of ITP, between October 2011 and April 2013, were included in the study. Data was collected from bone marrow reports and outpatient records. A total of 353 cases were found. 319 cases had features of typical ITP and the rest had some form of organomegaly and/or lymphadenopathy. Bone marrow examination in all cases revealed normal hematopoietic elements and prominence of megakaryocytes including juvenile forms with no novel diagnosis in any patient. Routine use of bone marrow examination in the diagnostic workup of isolated thrombocytopenia is not required in our center even if steroids are planned as a first line therapy. However, a detailed history, thorough examination with complete hemogram and peripheral smear examination are essential. PMID:27065582

  4. Changing health in China: re-evaluating the epidemiological transition model.

    Science.gov (United States)

    Cook, Ian G; Dummer, Trevor J B

    2004-03-01

    This paper reviews the changing health situation in China, which has shown remarkable improvement in the 50 years since the founding of the People's Republic of China (PRC) in 1949. At first sight this improving health situation follows the classical epidemiological transition model. Just three decades ago health in China was characterised by high rates of infectious disease and early mortality (diseases of poverty) in a mainly peasant society. More recently infectious disease rates have decreased, with corresponding and extended morbidity and mortality associated with an aging population in a rapidly urbanising society. This process has given rise to new health problems, including chronic and degenerative diseases (diseases of affluence). Nonetheless, while there is some validity in the application of the epidemiological transition concept, further analysis demonstrates that China faces a new epidemiological phase, characterised by increasing life expectancy and diseases of affluence coupled with the emergence and re-emergence of infectious diseases. We demonstrate that China's state policy plays a major role in defining the parameters of health in a Chinese context. We conclude that, today, China is faced with a new set of health issues, including the impact of smoking, hypertension, the health effects of environmental pollution and the rise of HIV/AIDS; however, state policy remains vital to the health of China's vast population. The challenge for policy is to maintain health reform whilst tackling the problems associated with rapid urbanisation, widening social and spatial inequalities and the emergence of HIV/AIDS and other infectious diseases.

  5. Re-Evaluation of Constant versus Varied Punishers Using Empirically Derived Consequences

    Science.gov (United States)

    Toole, Lisa M.; DeLeon, Iser G.; Kahng, Sung Woo; Ruffin, Geri E.; Pletcher, Carrie A.; Bowman, Lynn G.

    2004-01-01

    Charlop, Burgio, Iwata, and Ivancic [J. Appl. Behav. Anal. 21 (1988) 89] demonstrated that varied punishment procedures produced greater or more consistent reductions of problem behavior than a constant punishment procedure. More recently, Fisher and colleagues [Res. Dev. Disabil. 15 (1994) 133; J. Appl. Behav. Anal. 27 (1994) 447] developed a…

  6. Reevaluating NIMBY: Evolving Public Fear and Acceptance in Siting a Nuclear Waste Facility

    International Nuclear Information System (INIS)

    The not-in-my-backyard (NIMBY) syndrome has long been the focus of academic and policy research. We test several competing hypothesis concerning the sources of NIMBY sentiments, including demographics, proximity, political ideology and partisanship, and the unfolding policy process over time. To test these hypotheses we use survey data collected in New Mexico dealing with risk perceptions and acceptance related to the Waste Isolation Pilot Project (WIPP), a permanent storage site for radioactive waste located near Carlsbad, New Mexico. WIPP became operational and received its first shipment of waste on March 26, 1999. This study tracks the changes of risk perception and acceptance over a decade, using measures taken from 35 statewide surveys of New Mexico citizens spanning the 11-year period from fall 1990 to summer 2001. This time span includes periods before and after WIPP became operational. We find that acceptance of WIPP is greater among those in the most proximate counties to WIPP. Surprisingly, and contrary to expectations drawn from the broader literature, acceptance is also greater among those who live closest to the nuclear waste transportation route. We also find that ideology, partisanship, government approval and broader environmental concerns influence support for WIPP acceptance. Finally, the sequence of procedural steps taken toward formal approval of WIPP by government agencies proved to be important to public acceptance, the most significant being the opening of the WIPP facility itself

  7. Recruitment processes in Baltic sprat - A re-evaluation of GLOBEC Germany hypotheses

    DEFF Research Database (Denmark)

    Voss, Rudiger; Peck, M.A.; Hinrichsen, H.-H.;

    2012-01-01

    projections of the future strength of the Balticsprat stock will need to take into account climate-driven changes in both abiotic (e.g., drift trajectories) and biotic (trophodynamic) factors. Although our understanding ofprocesses affecting pre-recruit (larval) growth and survival has been advanced......The GLOBEC Germany program (2002–2007) had the ambitious goal to resolve the processes impacting the recruitment dynamics ofBalticsprat (Sprattus sprattus L.) by examining various factors affecting early life history stages. At the start of the research program, a number of general...... for year-class strength particularly at high sprat stock sizes. A suggested mechanism is density-dependant regulation of survival via intra- and inter-specific competition for prey in coastal areas. A documented change in larval vertical migration behavior between the early 1990s and early 2000s increased...

  8. Low genetic diversity in a marine nature reserve: re-evaluating diversity criteria in reserve design

    OpenAIRE

    Bell, J.J; Okamura, B.

    2005-01-01

    Little consideration has been given to the genetic composition of populations associated with marine reserves, as reserve designation is generally to protect specific species, communities or habitats. Nevertheless, it is important to conserve genetic diversity since it provides the raw material for the maintenance of species diversity over longer, evolutionary time-scales and may also confer the basis for adaptation to environmental change. Many current marine reserves are small in size and i...

  9. Re-evaluation of model-based light-scattering spectroscopy for tissue spectroscopy.

    Science.gov (United States)

    Lau, Condon; Sćepanović, Obrad; Mirkovic, Jelena; McGee, Sasha; Yu, Chung-Chieh; Fulghum, Stephen; Wallace, Michael; Tunnell, James; Bechtel, Kate; Feld, Michael

    2009-01-01

    Model-based light scattering spectroscopy (LSS) seemed a promising technique for in-vivo diagnosis of dysplasia in multiple organs. In the studies, the residual spectrum, the difference between the observed and modeled diffuse reflectance spectra, was attributed to single elastic light scattering from epithelial nuclei, and diagnostic information due to nuclear changes was extracted from it. We show that this picture is incorrect. The actual single scattering signal arising from epithelial nuclei is much smaller than the previously computed residual spectrum, and does not have the wavelength dependence characteristic of Mie scattering. Rather, the residual spectrum largely arises from assuming a uniform hemoglobin distribution. In fact, hemoglobin is packaged in blood vessels, which alters the reflectance. When we include vessel packaging, which accounts for an inhomogeneous hemoglobin distribution, in the diffuse reflectance model, the reflectance is modeled more accurately, greatly reducing the amplitude of the residual spectrum. These findings are verified via numerical estimates based on light propagation and Mie theory, tissue phantom experiments, and analysis of published data measured from Barrett's esophagus. In future studies, vessel packaging should be included in the model of diffuse reflectance and use of model-based LSS should be discontinued. PMID:19405760

  10. Reevaluation of whether a soma-to-germ-line transformation extends lifespan in Caenorhabditis elegans.

    Science.gov (United States)

    Knutson, Andrew Kekūpa'a; Rechtsteiner, Andreas; Strome, Susan

    2016-03-29

    The germ lineage is considered to be immortal. In the quest to extend lifespan, a possible strategy is to drive germ-line traits in somatic cells, to try to confer some of the germ lineage's immortality on the somatic body. Notably, a study in Caenorhabditis elegans suggested that expression of germ-line genes in the somatic cells of long-lived daf-2 mutants confers some of daf-2's long lifespan. Specifically, mRNAs encoding components of C. elegans germ granules (P granules) were up-regulated in daf-2 mutant worms, and knockdown of individual P-granule and other germ-line genes in daf-2 young adults modestly reduced their lifespan. We investigated the contribution of a germ-line program to daf-2's long lifespan and also tested whether other mutants known to express germ-line genes in their somatic cells are long-lived. Our key findings are as follows. (i) We could not detect P-granule proteins in the somatic cells of daf-2 mutants by immunostaining or by expression of a P-granule transgene. (ii) Whole-genome transcript profiling of animals lacking a germ line revealed that germ-line transcripts are not up-regulated in the soma of daf-2 worms compared with the soma of control worms. (iii) Simultaneous removal of multiple P-granule proteins or the entire germ-line program from daf-2 worms did not reduce their lifespan. (iv) Several mutants that robustly express a broad spectrum of germ-line genes in their somatic cells are not long-lived. Together, our findings argue against the hypothesis that acquisition of a germ-cell program in somatic cells increases lifespan and contributes to daf-2's long lifespan.

  11. [Re-evaluation of using acupuncture needle as sphenoidal electrode in temporal lobe epilepsy].

    Science.gov (United States)

    Chu, Nai-Shin

    2009-06-01

    In 1965, Feng of the Peking Union Hospital published an article entitled "Innovation in electroencephalography: the use of acupuncture needles as sphenoidal electrodes". It was a preliminary report, but surprisingly EEG records in the figures did not show definite spikes or sharp waves in the sphenoidal leads. In 1983, Feng and his colleagues reported a summary of 2,000 cases studied with acupuncture needle sphenoidal electrodes. This time, spikes or sharp waves were shown in EEG recordings. However, cases studied were several "paroxysmal disorders", including psychomotor seizure (155 cases), generalized seizure (765 cases), epileptic cephalgia (101 cases), syncope (104 cases), abdominal epilepsy (24 cases), encephalopathy (135 cases), brain tumor (32 cases), hemiplegia of unknown cause (43 cases), psychosis (34 cases), and others (607 cases). Therefore, there were many unknown cases and many cases that were not related to temporal lobe epilepsy. Surprisingly, the increase in detection by acupuncture needle electrode was higher for hemiplegia of unknown cause, brain tumors, and encephalopathies than for the temporal lobe epilepsy. Furthermore, the issue of no insulation of the acupuncture needle was not addressed. Therefore, we began in 1988 to reinvestigate the usefulness of uninsulated acupuncture needles as sphenoidal electrodes. We also compared the efficacy of anterior temporal electrodes (T1, T2) with those of acupuncture needle and EMG needle. Our results showed that when compared to the routine EEG recordings, acupuncture needle sphenoidal electrodes increased the yield of detecting anterior temporal spikes from 41% to 70%. Our data further showed that when compared to the EMG needle recordings, acupuncture needle recordings had the same detection rate, but the spike amplitude was slightly smaller (129 microv vs. 135 microv). Interestingly, we also found that anterior temporal surface electrode recordings were nearly as good as those of acupuncture needle and traditional insulated needle electrodes in the detection of anterior temporal spikes. Our data indicate that acupuncture needle sphenoidal electrode is as effective as the traditional insulated needle sphenoidal electrode in the detection of anterior temporal spikes. We agree with Feng that the use of acupuncture needle is easy, safe, and has minimal discomfort and complications. However, when the use of the acupuncture needle is not acceptable to patients or as in the pediatric group, anterior temporal electrode is an ideal alternative to acupuncture needle sphenoidal electrode. PMID:19673369

  12. Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes.

    Science.gov (United States)

    Martomo, Stella A; Saribasak, Huseyin; Yokoi, Masayuki; Hanaoka, Fumio; Gearhart, Patricia J

    2008-09-01

    DNA polymerase theta has been implicated in the process of somatic hypermutation in immunoglobulin variable genes based on several reports of alterations in the frequency and spectra of mutations from Polq(-/-) mice. However, these studies have contrasting results on mutation frequencies and the types of nucleotide substitutions, which question the role of polymerase theta in hypermutation. DNA polymerase eta has a dominant effect on mutation and may substitute in the absence of polymerase theta to affect the pattern. Therefore, we have examined mutation in mice deficient for both polymerases theta and eta. The mutation frequencies in rearranged variable genes from Peyer's patches were similar in wild type, Polq(-/-), Polh(-/-), and Polq(-/-)Polh(-/-) mice. The types of substitutions were also similar between wild type and Polq(-/-) clones, and between Polh(-/-) and Polq(-/-)Polh(-/-) clones. Furthermore, there was no difference in heavy chain class switching in splenic B cells from the four groups of mice. These results indicate that polymerase theta does not play a significant role in the generation of somatic mutation in immunoglobulin genes.

  13. Reevaluation of an Acanthamoeba Molecular Diagnostic Algorithm following an Atypical Case of Amoebic Keratitis.

    Science.gov (United States)

    Lau, Rachel; Cunanan, Marlou; Jackson, Jonathan; Ali, Ibne Karim M; Chong-Kit, Ann; Gasgas, Jason; Tian, Jinfang; Ralevski, Filip; Boggild, Andrea K

    2015-10-01

    Amoebic keratitis (AK) is a potentially blinding infection, the prompt diagnosis of which is essential for limiting ocular morbidity. We undertook a quality improvement initiative with respect to the molecular detection of acanthamoebae in our laboratory because of an unusual case of discordance. Nine ATCC strains of Acanthamoeba and 40 delinked, biobanked, surplus corneal scraping specimens were analyzed for the presence of acanthamoebae with four separate real-time PCR assays. The assay used by the Free-Living and Intestinal Amebas Laboratory of the CDC was considered the reference standard, and the performance characteristics of each individual assay and pairs of assays were calculated. Outcome measures were sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Of 49 included specimens, 14 (28.6%) were positive by the gold standard assay, and 35 (71.4%) were negative. The sensitivities of the individual assays ranged from 64.3% to 92.9%, compared to the gold standard, while the specificities ranged from 88.6% to 91.4%. The PPVs and NPVs ranged from 69.2% to 78.6% and from 86.1% to 96.9%, respectively. Combinations of assay pairs led to improved performance, with sensitivities ranging from 92.9% to 100% and specificities ranging from 97.1% to 100%. ATCC and clinical strains of Acanthamoeba that failed to be detected by certain individual assays included Acanthamoeba castellanii, Acanthamoeba culbertsoni, and Acanthamoeba lenticulata. For three clinical specimens, false negativity of the gold standard assay could not be excluded. Molecular diagnostic approaches, especially combinations of highly sensitive and specific assays, offer a reasonably performing, operator-independent, rapid strategy for the detection of acanthamoebae in clinical specimens and are likely to be more practical than either culture or direct microscopic detection.

  14. Re-evaluation of the concrete faced rockfill dams in Turkey

    Energy Technology Data Exchange (ETDEWEB)

    Tosun, H. [Dam Safety Association, Ankara (Turkey); Turkoz, M. [Eskisehir Osmangazi University, Eskisehir (Turkey)

    2006-07-01

    One of the most popular types of dams in the world is the concrete faced rockfill dam (CFRD). In the 1940s, it was used for moderate height structures, however with the application of the vibratory roller, it quickly advanced. The concrete-faced rockfill dam is being constructed with increasing frequency, because it does not have settlement problems as a result of the use of compacted rockfill. It is thought that the entire rockfill mass increases the overall stability of the dam, since the water pressure acts on the upstream face. One of its advantages is that there can be no pore water pressure due to earthquake shaking, because the embankment does not include water inside. Therefore, it is not necessary to consider a strength reduction for embankment materials and have a high resistance to seismic loading when well compacted. Currently, CFRD's are designed with an upstream zone of small rock particles and soil materials without any permeability problems. The stability of slopes of concrete-faced rockfill dams can be analysed under different levels of seismic loading. In Turkey, the CFRD is increasingly popular. This paper described evaluation of design principles for CFRD's in Turkey and introduced the results of a study including deformation and stress analyses of the Kurtun Dam using the Finite Element Method and compared the calculated and measured values of settlement. The predicted values of settlement were compared with actual ones. It was concluded that settlement analysis using the finite element model is a credible method when suitable parameters of embankment materials are used in the analysis. 11 refs., 5 tabs., 7 figs.

  15. Finding Pearls: Psychometric Reevaluation of the Simpson-Troost Attitude Questionnaire (STAQ)

    Science.gov (United States)

    Owen, Steven V.; Toepperwein, Mary Anne; Marshall, Carolyn E.; Lichtenstein, Michael J.; Blalock, Cheryl L.; Liu, Yan; Pruski, Linda A.; Grimes, Kandi

    2008-01-01

    The Simpson-Troost Attitude Questionnaire (STAQ) was developed as part of a study to assess adolescent commitment to and achievement in science. For this psychometric reappraisal of the 57-item STAQ, data were analyzed from a convenience sample of 1,754 secondary students. Confirmatory and exploratory factor analyses were applied, and results…

  16. Multi-omic landscape of Rheumatoid Arthritis: re-evaluation of drug adverse effects

    OpenAIRE

    Paolo eTieri; XiaoYuan eZhou; Lisha eZhu; Christine eNardini

    2014-01-01

    Objective: To provide a frame to estimate the systemic impact (side/adverse events) of (novel) therapeutic targets by taking into consideration drugs potential on the numerous districts involved in rheumatoid arthritis (RA) from the inflammatory and immune response to the gut-intestinal (GI) microbiome.Methods: We curated the collection of molecules from high-throughput screens of diverse (multi-omic) biochemical origin, experimentally associated to RA. Starting from such collection we genera...

  17. Multi-omic landscape of rheumatoid arthritis: re-evaluation of drug adverse effects

    OpenAIRE

    Tieri, Paolo; Zhou, Xiaoyuan; Zhu, Lisha; Nardini, Christine

    2014-01-01

    Objective: To provide a frame to estimate the systemic impact (side/adverse events) of (novel) therapeutic targets by taking into consideration drugs potential on the numerous districts involved in rheumatoid arthritis (RA) from the inflammatory and immune response to the gut-intestinal (GI) microbiome. Methods: We curated the collection of molecules from high-throughput screens of diverse (multi-omic) biochemical origin, experimentally associated to RA. Starting from such collection we ge...

  18. Multi-omic landscape of Rheumatoid Arthritis: re-evaluation of drug adverse effects

    Directory of Open Access Journals (Sweden)

    Paolo eTieri

    2014-11-01

    Full Text Available Objective: To provide a frame to estimate the systemic impact (side/adverse events of (novel therapeutic targets by taking into consideration drugs potential on the numerous districts involved in rheumatoid arthritis (RA from the inflammatory and immune response to the gut-intestinal (GI microbiome.Methods: We curated the collection of molecules from high-throughput screens of diverse (multi-omic biochemical origin, experimentally associated to RA. Starting from such collection we generated RA-related protein-protein interaction (PPI networks (interactomes based on experimental PPI data. Pharmacological treatment simulation, topological and functional analyses were further run to gain insight into the proteins most affected by therapy and by multi-omic modelling.Results: Simulation on the administration of MTX results in the activation of expected (apoptosis and adverse (nitrogenous metabolism alteration effects. Growth factor receptor-bound protein 2 (GRB2 and Interleukin-1 Receptor Associated Kinase-4 (IRAK4, already an RA target emerge as relevant nodes. The former controls the activation of inflammatory, proliferative and degenerative pathways in host and pathogens. The latter controls immune alterations and blocks innate response to pathogens.Conclusions: This multi-omic map properly recollects in a single analytical picture known, yet complex, information like the adverse/side effects of MTX, and provides a reliable platform for in silico hypothesis testing or recommendation on novel therapies. These results can support the development of RA translational research in the design of validation experiments and clinical trials, as such we identify GRB2 as a robust potential new target for RA for its ability to control both synovial degeneracy and dysbiosis, and, conversely, warn on the usage of IRAK4-inhibitors recently promoted, as this involves potential adverse effects in the form of impaired innate response to pathogens.

  19. Re-evaluating the Frankfurt isothermal static diffusion chamber for ice nucleation

    Science.gov (United States)

    Schrod, Jann; Danielczok, Anja; Weber, Daniel; Ebert, Martin; Thomson, Erik S.; Bingemer, Heinz G.

    2016-03-01

    Recently significant advances have been made in the collection, detection and characterization of ice nucleating particles (INPs). Ice nuclei are particles that facilitate the heterogeneous formation of ice within the atmospheric aerosol by lowering the free energy barrier to spontaneous nucleation and growth of ice from atmospheric water and/or vapor. The Frankfurt isostatic diffusion chamber (FRankfurt Ice nucleation Deposition freezinG Experiment: FRIDGE) is an INP collection and offline detection system that has become widely deployed and shows additional potential for ambient measurements. Since its initial development FRIDGE has gone through several iterations and improvements. Here we describe improvements that have been made in the collection and analysis techniques. We detail the uncertainties inherent in the measurement method and suggest a systematic method of error analysis for FRIDGE measurements. Thus what is presented herein should serve as a foundation for the dissemination of all current and future measurements using FRIDGE instrumentation.

  20. A reevaluation of myceliogenic germination of sclerotia for Sclerotinia sclerotiorum strain Sun-87

    Science.gov (United States)

    Basal stalk rot of sunflower is an economically important, and rather unique disease, among crops that are susceptible to Sclerotinia sclerotiorum. This disease is the result of myceliogenic germination of sclerotia whereby the vegetative hyphae infect the sunflower below the soil level. In contrast...

  1. A conserved class of queen pheromones? Re-evaluating the evidence in bumblebees (Bombus impatiens).

    Science.gov (United States)

    Amsalem, Etya; Orlova, Margarita; Grozinger, Christina M

    2015-10-22

    The regulation of reproductive division of labour is a key component in the evolution of social insects. Chemical signals are important mechanisms to regulate worker reproduction, either as queen-produced pheromones that coercively inhibit worker reproduction or as queen signals that honestly advertise her fecundity. A recent study suggested that a conserved class of hydrocarbons serve as queen pheromones across three independent origins of eusociality. In bumblebees (Bombus terrestris), pentacosane (C25) was suggested to serve as a queen pheromone. Here, we repeat these studies using a different species of bumblebee (Bombus impatiens) with a more controlled experimental design. Instead of dequeened colonies, we used same-aged, three-worker queenless groups comprising either experienced or naive workers (with/without adult exposure to queen pheromone). We quantified three hydrocarbons (C23, C25 and C27) on the cuticular surfaces of females and tested their effects on the two worker types. Our results indicate differences in responses of naive and experienced workers, genetic effects on worker reproduction, and general effects of hydrocarbons and duration of egg laying on ovary resorption rates. However, we found no evidence to support the theory that a conserved class of hydrocarbons serve as queen pheromones or queen signals in Bombus impatiens. PMID:26490791

  2. Carbon isotope ratios of Phanerozoic marine cements: Re-evaluating the global carbon and sulfur systems

    Science.gov (United States)

    Carpenter, Scott J.; Lohmann, Kyger C.

    1997-11-01

    Original δ 13C values of abiotically precipitated marine cements from a variety of stratigraphic intervals have been used to document secular variations in the δ 13C values of Phanerozoic oceans. These, together with the ° 34S values of coeval marine sulfates, are used to examine the global cycling of carbon and sulfur. It is generally accepted that secular variation in δ 13C and δ 34S values of marine carbonates and sulfates is controlled by balanced oxidation-reduction reactions and that their long-term, steady-state variation can be predicted from the present-day isotopic fractionation ratio (Δ c/Δ s) the ratio of the riverine flux of sulfur and carbon ( Fs/ Fc). The predicted slope of the linear relation between δ 13C carb and δ 34S sulfate values is approximately -0.10 to -0.14. However, temporal variation observed in marine cement δ 13C values and the 6345 values of coeval marine sulfates produces a highly significant linear relation ( r2 = 0.80; α > 95%) with a slope of -0.24; approximately twice the predicted value. This discordance suggests that either the Phanerozoic average riverine Fs/ Fc was 1.6-3.3 times greater than today's estimates or that an additional source of 34S-depleted sulfur or 13C-enriched carbon, other than continental reservoirs, was active during the Phanerozoic. This new relation between marine δ 13C and δ 34S values suggests that the flux of reduced sulfur, iron, and manganese from seafloor hydrothermal systems affects oceanic O2 levels which, in turn, control the oxidation or burial of organic matter, and thus the δ 13C value of marine DIC. Therefore, the sulfur system (driven by seafloor hydrothermal systems) controls the carbon system rather than organic carbon burial controlling the response of δ 34S values (via formation of sedimentary pyrite). Secular variation of marine 87Sr/86Sr ratios and δ 13C values argues for a coupling of δ 34S and δ 34S values to variation in the relative contribution of seafloor hydrothermal and continental weathering fluxes. These trends indicate that the early Paleozoic was dominated by low temperature silicate weathering, whereas the Late Paleozoic to Modern was dominated by high temperature seawater-basalt interactions. Variation in Proterozoic δ 13C carb and δ 34S sulfate values produces a slope that is greater than that of the Phanerozoic ( -0.50 vs. -0.24). This steeper slope is consistent with other geochernical data that indicate relatively high seafloor hydrothermal fluxes during the late Precambrian. We speculate that the dramatic evolutionary changes of the Neoproterozoic-Paleozoic transition occur during a waning of seafloor hydrothermal fluxes and a concomitant decrease in O 2 consumption that permitted the oxygenation of seawater thought to be critical in metazoan evolution.

  3. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis.

    Directory of Open Access Journals (Sweden)

    Suzhen Jiang

    Full Text Available To examine the role of hepatitis B virus (HBV integration in hepatocarcinogenesis, a systematic comparative study of both tumor and their corresponding non-tumor derived tissue has been conducted in a cohort of 60 HBV associated hepatocellular carcinoma (HCC patients. By using Alu-polymerase chain reaction (PCR and ligation-mediated PCR, 233 viral-host junctions mapped across all human chromosomes at random, no difference between tumor and non-tumor tissue was observed, with the exception of fragile sites (P = 0.0070. HBV insertions in close proximity to cancer related genes such as hTERT were found in this study, however overall they were rare events. No direct correlation between chromosome aberrations and the number of HBV integration events was found using a sensitive array-based comparative genomic hybridization (aCGH assay. However, a positive correlation was observed between the status of several tumor suppressor genes (TP53, RB1, CDNK2A and TP73 and the number of chromosome aberrations (r = 0.6625, P = 0.0003. Examination of the viral genome revealed that 43% of inserts were in the preC/C region and 57% were in the HBV X gene. Strikingly, approximately 24% of the integrations examined had a breakpoint in a short 15 nt viral genome region (1820-1834 nt. As a consequence, all of the confirmed X gene insertions were C-terminal truncated, losing their growth-suppressive domain. However, the same pattern of X gene C-terminal truncation was found in both tumor and non-tumor derived samples. Furthermore, the integrated viral sequences in both groups had a similar low frequency of C1653T, T1753V and A1762T/G1764A mutations. The frequency and patterns of HBV insertions were similar between tumor and their adjacent non-tumor samples indicating that the majority of HBV DNA integration events are not associated with hepatocarcinogenesis.

  4. Scientific Opinion on the re-evaluation of hexamethylene tetramine (E 239 as a food additive

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Food Additives and Nutrient Sources added to food (ANS

    2014-06-01

    Full Text Available Hexamethylene tetramine (HMT is a food additive, currently only permitted in EU for use in Provolone cheese. The maximum permitted level is 25 mg/kg residual amount, expressed as formaldehyde, the break down product of HMT under acidic conditions. HMT has been previously evaluated by the Joint Expert Committee on Food Additives (JECFA, 1974 who established an ADI of 0.15 mg/kg bw/day based on a reproductive study with a NOEL of 15 mg/kg bw/day. Due to the limitations in the database the Panel could not identify a critical study and therefore to derive an ADI. However, the Panel noted that the exposure to formaldehyde from HMT of high level consumers of Provolone cheese equalled 18 µg formaldehyde/kg bw/day in adults and could be as high as 87 µg formaldehyde/kg bw/day in children according to a theoretical conservative assumption that all ripened cheese consumed was Provolone cheese. Considering the estimated exposure from the very limited permitted use, the toxicological database on HMT, the data from use of HMT therapeutically, the available oral toxicity and toxicokinetic data of formaldehyde and the magnitude of the potential effect on intracellular formaldehyde levels arising from this use of HMT, the Panel concluded that the use of HMT in Provolone cheese at the MPL of 25 mg/kg residual amount, expressed as formaldehyde, would not be of safety concern. However the Panel considered that any increase in the permitted uses of HMT or increases in the MPL of 25 mg /kg residual amount, expressed as formaldehyde would need detailed assessment which might require new toxicity data as well as use levels and/or an evaluation of its impact on formaldehyde levels in vivo.

  5. Scientific Opinion on the re-evaluation of microcrystalline wax (E 905 as a food additive

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS

    2013-04-01

    Full Text Available Following a request from the European Commission, the Panel on Food Additives and Nutrient Sources added to Food (ANS was asked to deliver a scientific opinion on microcrystalline wax (E 905 when used as a food additive. Microcrystalline wax (E 905 is authorised quantum satis as a surface treatment agent on non-chocolate confectionery, chewing gum and decorations, coatings and fillings, except fruit based fillings. It is also permitted as a surface treatment of melons, papaya, mango and avocado. The substance was evaluated by the Scientific Committee on Food (SCF in 1990 and 1995 and by the Joint FAO/WHO Expert Committee on Food Additives (JECFA, the latest in 1995. The JECFA established a group ADI of 20 mg/kg bw/day for mineral oils, paraffins and microcrystalline waxes. The Panel noted that all mineral oil products accumulated in tissues in a dose- and time-dependent manner with the exception of microcrystalline waxes. The Panel concluded that there is no concern for genotoxicity from microcrystalline wax (E 905. The Panel also considered that the available toxicity studies with mineral hydrocarbons, closely related from a chemical point of view with microcrystalline waxes, consistently reported no effects of concern associated with the intake of microcrystalline wax. The Panel further concluded that since no long-term toxicity and carcinogenicity studies with microcrystalline wax E 905 were available, no ADI could be established. The Panel also concluded that the conservative exposure estimates to microcrystalline wax (E 905 from its use at maximum permitted level (following quantum satis rules, resulted in a sufficient margin of safety compared to the NOAEL established by the Panel for the closely related high viscosity mineral oils, and therefore the use microcrystalline wax (E 905 as a food additive with the currently authorised uses would not be of safety concern.

  6. Reevaluation of Meta-analysis on prophylactic drug management for recurrence of febrile seizures

    Directory of Open Access Journals (Sweden)

    Huan LIAO

    2015-08-01

    Full Text Available Objective To explore the efficiency and safety of drugs to prevent the recurrence of febrile seizures (FS.  Methods Relevant literatures were searched via PubMed, EMBASE/SCOPUS, EBSCO-CINAHL, Web of Science, Cochrane Database of Systematic Reviews from December 1997 to November 2014 using the following keywords: febrile seizure OR febrile convulsion, recurrence, prevention OR prophylaxis, medicine OR medication. Publication type was limited to Meta-analysis. Extract the relevant information of Meta-analysis, such as characteristics of objects, types of study design, number of clinical trials, number of cases, search strategies, databases, information of methodology (methods of randomization, concealment, blinding, withdrawal and exit, follow-up time, heterogeneity analysis, subgroup analysis and outcome assessment, etc. Quality of Reporting of Meta-analyses (QUOROM and Oxman-Guyatt Overview Quality Assessment Questionnaire (OQAQ were used to assess the quality of included Meta-analyses. Jadad decision was used to assess inclusion and exclusion criteria, search strategies, effectiveness evaluation, data extraction and data analysis, to explore reliable evidence of evidence-based medicine.  Results Eventually, four Meta-analyses were included after screening of all the literatures that can be searched out. Among those Meta-analyses, the Meta-analysis of Offringa and Newton (2012 was relatively more reliable. The results suggesed that no clinically important benefits were found in administering intermittent oral or rectal diazepam, oral phenobarbitone, phenytoin, valproate, pyridoxine, buprofen, diclofenac and acetominophen to children with FE. Only one clinical trial reported that intermittent oral clobazam could reduce the recurrence of FE in comparing with placebo at 6-month follow-up (RR = 0.360, 95% CI: 0.200-0.640; P = 0.000, but it should be verified by more randomized controlled trials (RCTs. Among 4 Meta-analyses included in this study, the Meta-analyses of Rosenbloom (2013, Masuko (2003 and Rantala (1997 did not mention the problems of publication bias; in the Meta-analysis of Offringa and Newton (2012, a funnel plot was applied for evaluation of this problem, however, no quantitative analysis was conducted to evaluate the effect of publication bias on the validity of conclusions and no further processing was mentioned. Conclusions In view of good prognosis of recurrent FE, unsure efficacy of preventive medicine and high risk of adverse drug reactions, it should not be routinely recommended the use of antiepileptic drugs, antipyretic drugs or pyridoxine to prevent the recurrence of FE. DOI: 10.3969/j.issn.1672-6731.2015.08.011

  7. Reevaluation of the proposed autocrine proliferative function of prolactin in breast cancer

    DEFF Research Database (Denmark)

    Nitze, Louise Maymann; Galsgaard, Elisabeth Douglas; Din, Nanni;

    2013-01-01

    The pituitary hormone prolactin (PRL) has been implicated in tumourigenesis. Expression of PRL and its receptor (PRLR) was reported in human breast epithelium and breast cancer cells. It was suggested that PRL may act as an autocrine/paracrine growth factor. Here, we addressed the role of locally...

  8. Re-evaluation of the prolactin receptor expression in human breast cancer

    DEFF Research Database (Denmark)

    Galsgaard, Elisabeth Douglas; Rasmussen, Birgitte Bruun; Folkesson, Charlotta Grånäs;

    2009-01-01

    The pituitary hormone PRL is involved in tumorigenesis in rodents and humans. PRL promotes proliferation, survival and migration of cancer cells acting via the PRL receptor (PRLR). Aiming to perform a large-scale immunohistochemical (IHC) screening of human mammary carcinomas for PRLR expression,...

  9. Aragonian stratigraphy reconsidered, and a re-evaluation of the middle Miocene mammal biochronology in Europe

    NARCIS (Netherlands)

    Daams, R.; Meulen, A.J. van der; Alvarez Sierra, M.A.; Peláez-Campomanes, P.; Krijgsman, W.

    2001-01-01

    The recently collected fauna of Armantes 1A in Chron C5Br of the Armantes section necessitates reinterpretation of the previous bio- and magnetostratigraphical correlations between the Armantes and Vargas sections (Calatayud-Daroca Basin, Central Spain) [W. Krijgsman, M. Garcés, C.G. Langereis, R. D

  10. Re-evaluation of an animal model for ADHD using a free-operant choice task.

    Science.gov (United States)

    Pardey, Margery C; Homewood, Judi; Taylor, Alan; Cornish, Jennifer L

    2009-01-30

    Previous research using free-operant procedures have reported that the Spontaneously Hypertensive Rat (SHR) is more impulsive and inattentive than the Wistar-Kyoto (WKY) rat. Recently these behavioural differences have been suggested to be a consequence of differences in the overall activity of these strains. This study compared SHRs to WKYs on locomotor activity and delay sensitivity using a delayed reinforcement (DR) and extinction (EXT) task. SHRs maintained higher locomotor activity than WKYs, however no significant group differences were found on the total lever presses in the DR or EXT tasks. During the DR task, SHRs shifted to selecting the immediate small reinforcer significantly faster than WKYs as the delay increased. WKYs predominantly selected the lever previously associated with the delayed large reinforcer throughout the EXT task, while the SHRs showed no such preference. The significant group differences found on lever selection during the DR and EXT tasks suggests that SHRs are more sensitive to delays, therefore providing further support for the face validity of the SHR as an animal model of ADHD. PMID:18835408

  11. Reevaluating the first and the second dividends of environmental tax reforms

    International Nuclear Information System (INIS)

    There is increasing global interest in market-based climate change policies following the last elections in the United States. In this context an Exxon Mobil chief executive came out in favour of a carbon tax. This paper is concerned with the welfare analysis of Environmental Tax Reforms (ETR), and takes up the claims for the need of an unambiguous and operative definition of the double dividend both for empirical purposes and political advisement. In this paper, we contest the usual definition of the second dividend and its assimilation to an 'efficiency dividend'. We propose alternative definitions by suggesting a different splitting of the total welfare variation between the first and the second dividend in order to isolate the efficiency effects of the ETR. The new definitions become clearly understandable and easy for economic and policy interpretation. Concepts like 'weak' and 'strong' double dividend turn out to be unnecessary. Finally, we analyze ETR for the US economy to illustrate the advantages of the proposed definitions for policy implementation.

  12. Thyroid cancer. Reevaluation of an experimental model for radiogenic endocrine carcinogenesis

    International Nuclear Information System (INIS)

    The status of experimental studies of radiogenic thyroid cancer is appraised, and some older data are reinterpreted in the light of more recent findings. Problems of thyroid dosimetry, particularly the dosimetry of internal radioiodides, are discussed. The steps in radiation carcinogenesis during the acute phase, the latent phase, and the phase of tumor growth are discussed in terms of thyroid epithelial cell population changes. The roles of three cell populations (undamaged or completely repaired epithelial cells, oncogenically initiated cells, and terminally damaged but functionally competent cells) in neoplasia are described. Finally, the implications for man of these experimental results and conclusions are discussed. 89 refs., 4 figs

  13. Re-evaluation and continued development of shielding benchmark database SINBAD

    International Nuclear Information System (INIS)

    The Expert Group on Radiation Transport and Shielding was started at the OECD/NEA in June 2011 with the mandate to, among others, monitor, steer and support the continued development of the Shielding Integral Benchmark Archive and Database (SINBAD), in cooperation with RSICC. The present status of this database is presented, which grew since its beginnings in the 1990’s to an international reference database containing at present 100 benchmarks relevant for fission, fusion and accelerator shielding applications. As part of its activities a thorough revision of 45 benchmark experiments was completed recently in order to verify in details the completeness and consistency of the benchmark information, in particular concerning the evaluation of the experimental sources of uncertainty. This review process is expected to provide users with a proper choice and help them make better use of the experimental information and is planned to be extended to other available benchmarks. (author)

  14. Reevaluation of tsunami formation by debris avalanche at Augustine Volcano, Alaska

    Science.gov (United States)

    Waythomas, C.F.

    2000-01-01

    Debris avalanches entering the sea at Augustine Volcano, Alaska have been proposed as a mechanism for generating tsunamis. Historical accounts of the 1883 eruption of the volcano describe 6- to 9-meter-high waves that struck the coastline at English Bay (Nanwalek), Alaska about 80 kilometers east of Augustine Island. These accounts are often cited as proof that volcanigenic tsunamis from Augustine Volcano are significant hazards to the coastal zone of lower Cook Inlet. This claim is disputed because deposits of unequivocal tsunami origin are not evident at more than 50 sites along the lower Cook Inlet coastline where they might be preserved. Shallow water (out zone for debris avalanches, limits the size of an avalanche-caused wave. If the two most recent debris avalanches, Burr Point (A.D. 1883) and West Island (work (erosion, sediment transport, formation of wave-cut features) on the coastline of lowwer Cook Inlet. Because widespread evidence of the effects of large waves cannot be found, it appears that the debris avalanches could not have been traveling very fast when they entered the sea, or they happened during low tide and displaced only small volumes of water. In light of these results, the hazard from volcanigenic tsunamis from Augustine Volcano appears minor, unless a very large debris avalanche occurs at high tide.

  15. RE-EVALUATION OF SCHISTOSOMIASIS MANSONI IN MINAS GERAIS, BRAZIL. III. "NOROESTE DE MINAS" MESOREGION

    Directory of Open Access Journals (Sweden)

    CARVALHO Omar S.

    1998-01-01

    Full Text Available This study was conducted to assess the presence of schistosomiasis mansoni in the "Noroeste de Minas" mesoregion, an area considered non-endemic. A malacologic survey and parasitologic stool examinations were undertaken in 13 municipalities of the mesoregion. A sample of 3,283 primary school students was submitted to fecal examination by the Kato-Katz method. A total of 3,627 planorbids was collected and examined. The molluscs were identified as Biomphalaria straminea in seven municipalities (Unaí, Bonfinópolis de Minas, Paracatu, João Pinheiro, Vazante, Lagamar and Lagoa Grande and as Biomphalaria peregrina in one (Presidente Olegário. All planorbids were negative for Schistosoma mansoni. Four students were diagnosed with schistosomiasis in the municipalities of Buritis, Formoso, Paracatu and Unaí, but none of these cases was considered autochthonous. The data obtained indicate that the "Noroeste de Minas" mesoregion continues to be non-endemic for schistosomiasis mansoni, although the presence of intermediate hosts associated with parasitized individuals emphasizes the need for epidemiological surveillance of schistosomiasis in this mesoregion.

  16. Re-evaluating Okun's law in South Africa: A nonlinear co-integration approach

    OpenAIRE

    Phiri, Andrew

    2014-01-01

    This study undertakes an examination of asymmetric co-integration adjustment in Okun’s law for South Africa between the periods of 2000-2013. This objective is tackled through the use of momentum threshold autoregressive (MTAR) econometric framework. Contrary to conventional theory, the results show that unemployment granger causes economic growth in the long-run, a result which may account for the job-less growth experienced by South Africa over the last decade or so. The obtained results ha...

  17. Reevaluation of USTUR plutonium wound case 0262 using Bayesian methodology and new data.

    Science.gov (United States)

    Weber, Shane N; Brey, Richard R; James, Anthony C

    2012-09-01

    Skin penetration by radionuclide contaminants serves as a route of entry into the body and may pose a serious health risk to humans depending on the magnitude of intake. The United States Transuranium and Uranium Registry whole body Case 0262 was involved in a wound intake of plutonium at the Hanford Site. The registrant died about 33 years later. Results were initially reported in 2007 regarding the deposition and retention of plutonium in various tissues, including the wound site. However in 2009, an additional (previously unrecorded) sample of the wound tissue was located in the National Human Radiobiological Tissue Repository. The new sample was analyzed using inductively coupled plasma-mass spectrometry (ICP-MS), and the results were used to calibrate the measurement of emitted Pu x-rays from the original wound tissue sample made in 2007. In the present study, the analysis of Pu absorption rates from the wound and axillary lymph node from the initial study is repeated using the additional wound activity data and ICP-MS calibration. This new analysis is carried out using the Weighted Likelihood Monte Carlo Sampling (WeLMoS) method and code, which applies Bayesian inference to calculate the posterior probability distribution of intake and wound absorption parameters directly from the observed data and the assumed biokinetic model structure. The resulting central estimates of empirical wound absorption parameters and their associated uncertainties are here compared with the empirical values recommended in NCRP Report No. 156 for plutonium and with the maximum likelihood point estimates derived in the initial study from the Case 0262 data available at the time.

  18. Fluctuation spectra and variances in convective turbulent boundary layers: A reevaluation of old models

    Science.gov (United States)

    Yaglom, A. M.

    1994-02-01

    Most of the existing theoretical models for statistical characteristics of turbulence in convective boundary layers are based on the similarity theory by Monin and Obukhov [Trudy Geofiz. Inst. Akad. Nauk SSSR 24(151), 163 (1954)], and its further refinements. A number of such models was recently reconsidered and partially compared with available data by Kader and Yaglom [J. Fluid Mech. 212, 637 (1990); Turbulence and Coherent Structures (Kluwer, Dordrecht, 1991), p. 387]. However, in these papers the data related to variances =σ2u and =σ2v of horizontal velocity components were not considered at all, and the data on horizontal velocity spectra Eu(k) and Ev(k) were used only for a restricted range of not too small wave numbers k. This is connected with findings by Kaimal et al. [Q. J. R. Meteorol. Soc. 98, 563 (1972)] and Panofsky et al. [Boundary-Layer Meteorol. 11, 355 (1977)], who showed that the Monin-Obukhov theory cannot be applied to velocity variance σ2u and σ2v and to spectra Eu(k) and Ev(k) in energy ranges of wave numbers. It is shown in this paper that a simple generalization of the traditional similarity theory, which takes into account the influence of large-scale organized structures, leads to new models of horizontal velocity variances and spectra, which describe the observed deviations of these characteristics from the predictions based on the Monin-Obukhov theory, and agree satisfactorily with the available data. The application of the same approach to the temperature spectrum and variance explains why the observed deviations of temperature spectrum in convective boundary layers from the Monin-Obukhov similarity does not lead to marked violations of the same similarity as applied to temperature variance =σ2t.

  19. Is CLIL so Beneficial, or Just Selective? Re-Evaluating Some of the Research

    Science.gov (United States)

    Bruton, Anthony

    2011-01-01

    A number of studies on CLIL, particularly from Spain, which is familiar to this author, will be analysed to show that there are numerous anomalies not only in the research, but in the analysis, and doubts about the conclusions drawn. CLIL instruction is not always necessarily that beneficial, and there is every reason to believe some students may…

  20. Re-evaluation of the functional anatomy of the basal ganglia in normal and Parkinsonian states.

    Science.gov (United States)

    Levy, R; Hazrati, L N; Herrero, M T; Vila, M; Hassani, O K; Mouroux, M; Ruberg, M; Asensi, H; Agid, Y; Féger, J; Obeso, J A; Parent, A; Hirsch, E C

    1997-01-01

    In the late 1980s, a functional and anatomical model of basal ganglia organization was proposed in order to explain the clinical syndrome of Parkinson's disease. According to this model, the pathological overactivity observed in the subthalamic nucleus and the output station of the basal ganglia plays a crucial role in the pathophysiology of the motor signs of Parkinson's disease. The hyperactivity of subthalamic neurons in Parkinsonism is viewed as a direct consequence of a pathological hypoactivity of the external segment of the pallidum. This article reviews recent data from different experimental approaches that challenge the established model of basal ganglia organization by reinterpreting the functional interaction between the external segment of the pallidum and the subthalamic nucleus in both the normal and pathological state. Indeed, recent neurobiochemical studies have rather unexpectedly shown that the GABAergic and metabolic activities of the external pallidum are not decreased in human and non-human primates with Parkinsonism. This absence of any decrease in activity might be explained by the functionally antagonistic influences of the striatal and subthalamic afferences within the external pallidum, as suggested by several anatomical studies. In addition, there are clues from electrophysiological studies to suggest that the hyperactivity found in the subthalamic neurons in Parkinsonism may not depend solely on the level of activity in the external pallidum. In such a framework, the hyperactivity of the subthalamic neurons would have to be explained, at least in part, by other sources of excitation or disinhibition. However, any explanation for the origin of the subthalamic overactivity in Parkinsonism remains speculative.

  1. Development of seismic safety reevaluation procedure considering the ageing of NPP facilities

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Myoung Kue [Jeonju Univ., Cheonju (Korea, Republic of); Kim, J. M. [Cheonnam National Univ., Gwangju (Korea, Republic of); Kim, Y. S.; Cheong, S. H.; Kim, I. S.; Lee, M. G.; Kim, D. O. [Andong National Univ., Andong (Korea, Republic of); Lee, G. H. [Mokpo National Maritime Univ., Mokpo (Korea, Republic of)

    2003-03-15

    There are three of Nuclear Power Plants subject to the USI A-46 in Korea, including Kori No 1 and No 2 and Wolsung No 1. For the sake of resolution of the issue the possibility of adopting the GIP developed by the SQUG in USA is very high. In relation to the issue, this study addresses some technical improvements of the GIP including sloshing analysis based on multiple modes, seismic retrofit of cabinet for reduction of ICRS and modification of IRS depending on damping ratio. Dominant degradation factor and its affects NPP concrete elements are reviewed : chloride induced corrosion, carbonation of concrete elements, freezing and thawing of concrete elements, chemical and biological process, crack affect on concrete degradation. Various technical reports and papers about age-related degradation are reviewed for identification of degradation properties of NPP structures and components and degradation trend in NPP structures and components. This report summarizes numerical model for concrete degradation and development procedure of numerical models for concrete degradation. This report proposes the research necessity for performance evaluation of degraded concrete structure and selection of element for further study.

  2. Pandemic of Pregnant Obese Women: Is It Time to Re-Evaluate Antenatal Weight Loss?

    Directory of Open Access Journals (Sweden)

    Anne M. Davis

    2015-08-01

    Full Text Available The Obesity pandemic will afflict future generations without successful prevention, intervention and management. Attention to reducing obesity before, during and after pregnancy is essential for mothers and their offspring. Preconception weight loss is difficult given that many pregnancies are unplanned. Interventions aimed at limiting gestational weight gain have produced minimal maternal and infant outcomes. Therefore, increased research to develop evidence-based clinical practice is needed to adequately care for obese pregnant women especially during antenatal care. This review evaluates the current evidence of obesity interventions during pregnancy various including weight loss for safety and efficacy. Recommendations are provided with the end goal being a healthy pregnancy, optimal condition for breastfeeding and prevent the progression of obesity in future generations.

  3. The Lesser Antillean Ameiva (Sauria, Teiidae) Re-evaluation, zoogeography and the effects of predation

    NARCIS (Netherlands)

    Baskin, Jonathan N.; Williams, Ernest E.

    1966-01-01

    The Ameiva of the Lesser Antilles present an interesting case of isolated populations of related animals on a chain of islands that differ in size and proximity among themselves but form a geographic group. The situation is made still more interesting by the fact that at times in the Pleistocene the

  4. Reevaluation of the effect of calcium ions on auxin-induced elongation

    Energy Technology Data Exchange (ETDEWEB)

    Cleland, R.E. (Univ. of Washington, Seattle); Rayle, D.L.

    1977-01-01

    The mechanism by which calcium ions inhibit cell elongation has been reinvestigated. Growth-inhibiting levels of calcium, when applied to isolated walls (in vitro treatment) do not decrease cell wall extensibility as measured by the Instron technique. Thus, the hypothesis that calcium inhibits growth by forming wall-stiffening calcium bridges must be abandoned. Treatment of living auxin-treated sections with calcium (in vivo treatment) does cause a decrease in the subsequently measured wall extensibility, but this decline appears to be simply a consequence of the growth inhibition rather that its cause. Growth-inhibiting levels of calcium do not appreciably reduce the rate of auxin-enhanced H+ excretion. Pretreatment with calcium does not reduce the capacity of walls to undergo acid-activated wall loosening in the absence of calcium. High concentrations of CaC1/sub 2/ (0.02 M) cause an initial elastic shrinkage of Avena sections comparable to that caused by the same osmolarity of mannitol, but the subsequent growth inhibition is to great to be explained by an osmotic inhibition.Calcium ions do inhibit H+-induced extension of frozen-thawed sections under tension. The growth-inhibitory effects of calcium, then, may be ascribed to a direct inhibition exerted by calcium ions on the H+-induced wall-loosening process.

  5. 75 FR 31834 - Adoption of Environmental Impact Statement; Availability of an Environmental Reevaluation

    Science.gov (United States)

    2010-06-04

    ... mentioned benefits, the 2004 EIS contemplated a future high-speed rail system at the TTC in the form of a rail box that could accommodate high-speed rail trains. On the basis of the 2004 EIS, the FTA issued a... the train box under the High-Speed Intercity Passenger Rail Program. The American Recovery...

  6. Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape

    OpenAIRE

    Restifo, Nicholas P

    2000-01-01

    Based on early studies, it was hypothesized that expression of Fas ligand (FasL) by tumor cells enabled them to counterattack the immune system, and that transplant rejection could be prevented by expressing FasL on transplanted organs. More recent studies have indicated that the notion of FasL as a mediator of immune privilege needed to be reconsidered, and taught a valuable lesson about making broad conclusions based on small amounts of data.

  7. Re-Evaluating the Role of Energy Efficiency Standards: A Time-Consistent Behavioral Economics Approach

    OpenAIRE

    Tsvetan Tsvetanov; Kathleen Segerson

    2011-01-01

    The economic models that prescribe Pigovian taxation as the first-best means of reducing energy-related externalities and argue that taxes are superior to energy efficiency standards are typically based on the neoclassical model of rational consumer choice. Yet, observed consumer behavior with regards to energy use and the purchase of energy-using durable goods is generally thought to be far from efficient, giving rise to the concept of the “energy-efficiency gap.” In this paper, we present a...

  8. Re-evaluation of honeybees and wind on pollination of avocado

    Science.gov (United States)

    Avocado (Persea americana Mill) flowers, with their synchronously dichogamous behavior, are considered to be pollinated by honeybees, despite the lack of any direct evidence. Results in south Florida showed that avocado pollen was transferable by wind and dispersed over a brief period of time (15-60...

  9. Reevaluating NIMBY: Evolving Public Fear and Acceptance in Siting a Nuclear Waste Facility

    Energy Technology Data Exchange (ETDEWEB)

    Jenkins-Smith, Hank C.; Silva, Carol L.; Nowlin, Matthew C.; deLozier, Grant (Dept. of Political Science, Univ. of Oklahoma, Norman, OK (United States))

    2010-09-15

    The not-in-my-backyard (NIMBY) syndrome has long been the focus of academic and policy research. We test several competing hypothesis concerning the sources of NIMBY sentiments, including demographics, proximity, political ideology and partisanship, and the unfolding policy process over time. To test these hypotheses we use survey data collected in New Mexico dealing with risk perceptions and acceptance related to the Waste Isolation Pilot Project (WIPP), a permanent storage site for radioactive waste located near Carlsbad, New Mexico. WIPP became operational and received its first shipment of waste on March 26, 1999. This study tracks the changes of risk perception and acceptance over a decade, using measures taken from 35 statewide surveys of New Mexico citizens spanning the 11-year period from fall 1990 to summer 2001. This time span includes periods before and after WIPP became operational. We find that acceptance of WIPP is greater among those in the most proximate counties to WIPP. Surprisingly, and contrary to expectations drawn from the broader literature, acceptance is also greater among those who live closest to the nuclear waste transportation route. We also find that ideology, partisanship, government approval and broader environmental concerns influence support for WIPP acceptance. Finally, the sequence of procedural steps taken toward formal approval of WIPP by government agencies proved to be important to public acceptance, the most significant being the opening of the WIPP facility itself

  10. The mineral treasure that almost got away: Re-evaluating yesterday's mine waste

    Science.gov (United States)

    Högdahl, K.; Jonsson, E.; Troll, V.; Majka, J.

    2012-04-01

    Rare metals and semi-metals such as In, Ga, Se, Te and rare earth elements (REE) are increasing in demand for use in "new" and "green" technology. Yet, before the end of the 20th century the applications and thus the markets for these elements were limited. In many mines, the exploration paradigms and current knowledge as well as contemporary analytical methodology likely resulted in minerals hosting these metals to end up as waste, that is, on the mine dumps. In other cases, they were identified, but considered as mineralogical "exotica". Even extremely well-known and traditionally valuable metals such as gold went undetected on the dumps in some mine fields. This is due to a combination of factors such as that the deposits were "of the wrong type", assays were expensive, and suitable laboratory capacity sparse. This implies that in many regions, this old mine waste is a potential resource for several sought-after metals and semi-metals, including the ones increasingly used in modern high-tech applications. Admittedly, many older dumps and dump fields host only minor to moderate total amounts of material, but in todaýs society - increasingly focused on sustainability and related needs for recycling - this is likely to become an asset. In Sweden, many mine dumps date back hundreds of years or more as mining has been documented to go back at least 1000 years. Before the 20th century, only a single or, at best, a couple of metals were extracted from any given mine. Due to modern development in analytical techniques, the concentrations of trace elements, including highly sought-after metals and semi-metals can be obtained at moderate costs today. The presence of variable amounts of precious and rare elements along with the main ore commodity has now been documented in several cases. A recently started project in the classic, Palaeoproterozoic Bergslagen ore province in central Sweden is aimed at resolving the potential for finding and utilising these "unknown treasures". A conservative estimate based on SGU databases is that in this province alone, there are over 6500 mineralisations/deposits. A majority of these have associated mine dumps and in the case of more recently mined deposits, different types of tailings. Initial results highlight the high average contents of REÉs and identify their mineralogical and textural distribution in apatite-iron oxide ore present in both dumps and tailings. In addition, we report the occurrence of previously undetected mineralisation of indium and tungsten in different mine dumps in the western part of the province.

  11. Structural and Volumetric re-evaluation of the Vaiont landslide using DEM techniques

    Science.gov (United States)

    Superchi, Laura; Pedrazzini, Andrea; Floris, Mario; Genevois, Rinaldo; Ghirotti, Monica; Jaboyedoff, Michel

    2010-05-01

    On the 9th October 1963 a catastrophic landslide occurred on the southern slope of the Vaiont dam reservoir. A mass of approximately 270 million m3 collapsed into the reservoir generating a wave which overtopped the dam and hit the town of Longarone and other villages: almost 2000 people lost their lives. The large volume and high velocity of the landslide combined with the great destruction and loss of life that occurred make the Vaiont landslide as a natural laboratory to investigate landslide failure mechanisms and propagation. Geological, structural, geomorphological, hydrogeological and geomechanical elements should be, then, re-analyzed using methods and techniques not available in the '60s. In order to better quantify the volume involved in the movement and to assess the mechanism of the failure, a structural study is a preliminary and necessary step. The structural features have been investigated based on a digital elevation model (DEM) of the pre- and post-landslide topography at a pixel size of 5m and associated software (COLTOP-3D) to create a colored shaded relief map revealing the orientation of morphological features. Besides,the results allowed to identify on both pre- and post-slide surface six main discontinuity sets, some of which influence directly the Vaiont landslide morphology. Recent and old field surveys allowed to validate the COLTOP-3D analysis results. To estimate the location and shape of the sliding surface and to evaluate the volume of the landslide, the SLBL (Sloping Local Base Level) method has been used, a simple and efficient tool that allows a geometric interpretation of the failure surface based on a DEM. The SLBL application required a geological interpretation to define the contours of the landslide and to estimate the possible curvature of the sliding surface, that is defined by interpolating between points considered as limits of the landslide. The SLBL surface of the Vaiont landslide, was obtained from the DEM reconstruction of limits of the landslide defined by using geomorphological features and by literature data observed. Once the sliding plane was defined the potential sliding volume has been calculated in a GIS, considering also six different cross-sections realized along the landslide area before and after the event.

  12. Brazilian Alcohol Program (Proalcool): economic re-evaluation and demand adjustments

    International Nuclear Information System (INIS)

    The aim of this paper is to discuss the economic impact on the Brazilian National Alcohol Programme caused by changes in the energy scenery, in view of recent oil price fall in the international market, and evaluate the necessary adjustments of the Programme according to the new Brazilian economic reality. The economic analysis concludes that the alcohol production, considering current production capacity and its investments, could be economically feasible at international oil prices near US$ 30.00. Excluding investments, its feasibility would be between US$ 18.00 and US$ 20.00 per equivalent oil barrel. Based on these conclusions, proposals for adjusting the PROALCOOL are discussed, including alternative pricing, fiscal and credit policies to control the alcohol-fuel demand. (author)

  13. Re-evaluation of the socio-economical cost for straw

    International Nuclear Information System (INIS)

    The socio-economical price for straw is calculated. Prices per ton are for the year 1984, 230 Danish kroner per ton and 15.53 kroner per giga joule, for 1990, 291 kroner per ton and 19.40 per giga joule and for 1992, 171 kroner per ton and 11.81 per giga joule. This development reflects that in the case of some machines there has been a fall in price, and that the operation capacity has in many instances increased. The calculation of storage costs must be seen in relation to the current discussion on acceptable straw qualities. The calculated storage costs are based on the consideration of 6 storage possibilities. It was attempted to price the management methods in relation to equipment which is most used by farmers and lorry drivers daily. An example of this is that tranportation calculations are based on the probable use of secondhand renovated lorries, as new ones can not be afforded. Sliced straw is not included in the calculations. (AB) (16 refs.)

  14. Dosimetric comparison between three dimensional conformal radiotherapy, tomo-therapy and treatment by Cyberknife: about one case of a ponto cerebellar meningioma; Comparaison dosimetrique entre radiotherapie conformationnelle tridimensionnelle, tomotherapie et traitement par cyberknife: a propos d'un cas de meningiome de l'angle pontocerebelleux

    Energy Technology Data Exchange (ETDEWEB)

    Vasseur, F.; Rezvoy, N.; Lacornerie, T.; Lartigau, E. [Centre Oscar-Lambret, Dept. Universitaire de Radiotherapie, 59 - Lille (France)

    2009-10-15

    In order to illustrate the evolution of techniques in radiotherapy we compare the dose distributions calculated for the exclusive treatment of a ponto-cerebellar angle meningioma by a linear accelerator (clinac 2100) by helical irradiation and by cyberknife in radiosurgery mode and in fractionated mode. In conclusion: according to our first results, the tomo-therapy or the fractionated stereotactic radiotherapy appear as the treatments conjugating the advantages of stereotactic radiotherapy ( conformation of the dose to the target volume) and the fractionated radiotherapy ( protection of sane tissues by the fractionation). This study highlights the saving of sane tissues that allows these techniques. this better tolerance is to be evaluated. If it was confirmed, an increasing of the dose prescribed on the target volume could be considered. (N.C.)

  15. The contribution of three-dimensional intensity-modulated conformational radiotherapy (IMRT) in the Hodgkin disease: dosimetric study comparing tomo-therapy and three-dimensional conformation radiotherapy; Apport de la radiotherapie conformationnelle tridimensionnelle avec modulation d'intensite (RCMI) dans la maladie de Hodgkin: etude dosimetrique comparant une tomotherapie et une radiotherapie conformationnelle tridimensionnelle

    Energy Technology Data Exchange (ETDEWEB)

    Antoni, D.; Meyer, P.; Niederst, C.; Karamanoukian, D.; Noel, G. [Centre de lutte contre le cancer Paul-Strauss, 67 - Strasbourg (France); Bourahla, K. [Service de medecine nucleaire, centre Paul-Strauss, 67 - Strasbourg (France); Ame, S. [Service d' onco-hematologie, CHU Strasbourg, 67 - Strasbourg (France)

    2010-10-15

    A risk of cancer induced by chemotherapy or radiotherapy has been observed on a long term for patients suffering from the Hodgkin disease. The age at the time of irradiation and a high dose delivered in the breast could be the major risk factors for breast cancers. The authors report the results of the use of an IMRT which reduces these high doses. Notably, the planning target volume (PTV) is significantly better with the IMRT. The authors discuss the volume distribution of low doses for different organs. A long term monitoring is still required to confirm the interest of using IMRT. Short communication

  16. Monte-Carlo simulation of the SL-ELEKTA-20 medical linear accelerator. Dosimetric study of a water phantom; Simulation Monte Carlo de l'accelerateur lineaire clinique SL-ELEKTA 20. Etude dosimetrique dans un fantome d'eau

    Energy Technology Data Exchange (ETDEWEB)

    Thiam, Ch. O

    2003-06-01

    In radiotherapy, it is essential to have a precise knowledge of the dose delivered in the target volume and the neighbouring critical organs. To be usable clinically, the models of calculation must take into account the exact characteristics of the beams used and the densities of fabrics. Today we can use sophisticated irradiation techniques and get a more precise assessment of the dose and with a better knowledge of its distribution. Thus in this report, will be detailed a simulation of the head of irradiation of accelerator SL-ELEKTA-20 in electrons mode and a dosimetric study of a water phantom. This study is carried out with the code of simulation Monte Carlo GATE adapted for applications of medical physics; the results are compared with the data obtained by the anticancer center 'Jean Perrin' on a similar accelerator. (author)

  17. Radiotherapy for soft tissue sarcomas of extremities. Preliminary comparative dosimetric study of 3D conformal radiotherapy versus helical tomo-therapy; Radiotherapie postoperatoire des sarcomes des tissus mous des extremites. Etude dosimetrique preliminaire comparative de la radiotherapie conformationnelle avec la tomotherapie helicoidale

    Energy Technology Data Exchange (ETDEWEB)

    Donnay, L.; Dejean, C.; Amsellem, E.; Bourezgui, H.; Figueiredo, B.H. de; Duparc, A.; Caron, J.; Tournat, H.; Lagarde, P.; Kantor, G. [Centre Regional de Lutte Contre le Cancer, Dept. de Radiotherapie, 33 - Bordeaux (France); Stoeckle, E. [Centre Regional de Lutte Contre le Cancer, Dept. de Chirurgie, Institut Bergonie, 33 - Bordeaux (France)

    2008-12-15

    Purpose: To evaluate dosimetry of helical tomo-therapy versus three-dimensional conformal radiotherapy (3D-C.R.T.) with and without I.M.R.T. for the treatment of soft tissue sarcoma (S.T.S.) of the thigh. Methods and patients: A retrospective study was performed for three patients who received 3D-C.R.T. as adjuvant radiation therapy for S.T.S. of the thigh. These three patients had a tumor in posterior, adductor or anterior compartment of the thigh. In each case, three treatments plans were optimised in tomo-therapy, without bloc, with directional bloc and complete bloc of contralateral limb, to adequately treat the planning target volume and spare organ at risk. For each patient, we compare the three modalities of tomo-therapy or 'classical' I.M.R.T. from a Clinac with the 3D-C.R.T. actually performed for the treatment. Results: Tomo-therapy provides improved P.T.V. coverage and dose homogeneity. This benefit was comparable in the three tomo-therapy plans. The average D95% for tomo-therapy and 3D-C.R.T. were 97.6% and 94.8% respectively and the standard deviation is, at least, divided by two with conformal and is always better than performed with a Clinac. The volume of the surrounding soft tissues receiving at least full prescription and hot spots, as evaluated by D2%, were significantly reduced in tomo-therapy. Nevertheless, the results concerning the skin, the femur and the gonads were dependent on the tumor site in the thigh and not always improved with tomo-therapy dosimetric studies. (authors)

  18. Radiological and dosimetric consequences in case of nuclear accident: taking them into account within the security approach and protection challenges; Consequences radiologiques et dosimetriques en cas d'accident nucleaire: prise en compte dans la demarche de surete et enjeux de protection

    Energy Technology Data Exchange (ETDEWEB)

    Cogez, E.; Herviou, K.; Isnard, O.; Cessac, B.; Reales, N.; Quentric, E.; Quelo, D. [Institut de Radioprotection et de Surete Nucleaire, Direction de l' Environnement et de l' Intervention, Service des Situations d' Urgence et d' Organisation de Crise, BP 17 - 92262 Fontenay-aux-Roses (France)

    2010-07-01

    This report first proposes a presentation of the 'defence in depth' concept which comprises five as much as possible independent levels: preventing operation anomalies and system failures, maintaining the installation within the authorized domain, controlling accidents within design hypotheses, preventing the degradation of accidental conditions and limiting consequences of severe accidents, limiting radiological consequences for population in case of important releases. Then, after a description of a release atmospheric dispersion and of its consequences, this report describes the consequences of two accident scenarios. The first accident is a failure of steam generator tubes, and the second a loss of primary coolant. It notably indicates the main released radionuclides, exposure levels at different distance for a given set of dispersion conditions

  19. Report GT2 by the pluralistic expertise group on the Limousin uranium mining sites.Volume 1 and 2: Environmental, ecosystem and health controls. Environmental risk. Dose and health impacts; Rapport GT2 du Groupe d'Expertise Pluraliste sur les sites miniers d'uranium du Limousin. Surveillances environnementale, des ecosystemes et sanitaire. Risque environnemental Impacts dosimetrique et sanitaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    After a presentation of the expertise group and of its mission, the first volume reports the various controls and monitoring actions performed on the environment, on ecosystems, and on health. For each of this field, objectives, equipment, methods and results are presented, as well as the actors involved in data acquiring and gathering. Results are discussed and recommendations are proposed. With the same kind of approach (objectives, equipment, method and results), risks are assessed for the environment and for the population. The different standards of radiological and chemical exposure are presented. The second volume deals with the same topics and contains many documents detailing each of these issues

  20. Dosimetric comparison of volumetric modulated arc-therapy and intensity-modulated conformational radiotherapy in the treatment of prostate at high risk; Comparaison dosimetrique de l'arctherapie volumique modulee et de la radiotherapie conformationnelle avec modulation d'intensite dans le traitement de la prostate a haut risque

    Energy Technology Data Exchange (ETDEWEB)

    Largeron, G.; Pouchard, I.; Lorchel, F.; Passerat, V.; Barbet, N.; Khodri, M. [Centre de radiotherapie Orlam, Macon (France)

    2011-10-15

    The authors report a dosimetric comparison of IMRT (intensity-modulated radiotherapy) plans with that of volumetric-modulated arc-therapy in the case of treatment of high risk prostate, these plans being calculated on an Eclipse 8.9 (Varian{sup TM}) treatment planning system. The study is based on the treatment of 20 patients. Both techniques give similar results in terms of target volume coverage plan as well as in terms of organ-at-risk sparing, except for the plan with a single arc which results in smaller coverage and a lower homogeneity. Short communication

  1. Assessment of the dosimetric impact associated with the use of the car park of the Jean Laville stadium in the city of Gueugnon; Evaluation de l'impact dosimetrique lie a l'utilisation du parking du stade Jean Laville de la commune de Gueugnon (71)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    This document first reports and comments the assessment of external exposure associated with the use of a car park located on an ancient uranium contaminated zone (that has been rehabilitated): gamma dose rate measurements, assessment of the added yearly efficient dose associated with external exposure. It discusses the available data to assess the efficient dose added by internal exposure

  2. Development of a personalized dosimetric tool for radiation protection in case of internal contamination and targeted radiotherapy in nuclear medicine; Developpement d'un outil dosimetrique personnalise pour la radioprotection en contamination interne et la radiotherapie vectorisee en medecine nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Chiavassa, S

    2005-12-15

    Current internal dosimetric estimations are based on the M.I.R.D. formalism and used standard mathematical models. These standard models are often far from a given patient morphology and do not allow to perform patient-specific dosimetry. The aim of this study was to develop a personalized dosimetric tool, which takes into account real patient morphology, composition and densities. This tool, called O.E.D.I.P.E., a French acronym of Tool for the Evaluation of Personalized Internal Dose, is a user-friendly graphical interface. O.E.D.I.P.E. allows to create voxel-based patient-specific geometries and associates them with the M.C.N.P.X. Monte Carlo code. Radionuclide distribution and absorbed dose calculation can be performed at the organ and voxel scale. O.E.D.I.P.E. can be used in nuclear medicine for targeted radiotherapy and in radiation protection in case of internal contamination. (author)

  3. Dosimetry comparison of irradiation with conformal radiotherapy, intensity modulated radiotherapy, conformal radiotherapy in stereotactic conditions and robotic stereotactic radiotherapy for benign brain tumours; Comparaison dosimetrique de la radiotherapie conformationnelle, la radiotherapie conformationnelle avec modulation d'intensite, la radiotherapie conformationnelle en conditions stereotaxiques et la radiotherapie en conditions stereotaxiques robotisee des tumeurs cerebrales benignes

    Energy Technology Data Exchange (ETDEWEB)

    Spasic, E.; Noel, A. [Departement de radiophysique, centre Alexis-Vautrin, avenue de Bourgogne, 54511 Vandoeuvre-les-Nancy cedex (France); UMR 7039 CNRS, centre de recherche en automatique de Nancy (Cran), BP 239, 54506 Vandoeuvre-les-Nancy cedex (France); Cran UMR 7039, faculte des sciences et techniques, universite Henri-Poincare Nancy 1, BP 239, 54506 Vandoeuvre-les-Nancy cedex (France); Cran UMR 7039, institut national polytechnique de Lorraine, BP 239, 54506 Vandoeuvre-les-Nancy cedex (France); Buchheit, I.; Bernier, V. [Departement de radiophysique, centre Alexis-Vautrin, avenue de Bourgogne, 54511 Vandoeuvre-les-Nancy cedex (France)

    2011-07-15

    Purpose. - To compare several techniques in order to determine the best treatment for benign brain tumours. Methods and patients. - A retrospective study was performed for five patients who received 3D-conformal radiotherapy, intensity modulated radiotherapy or CyberKnife{sup R}. These patients had a meningioma, a pituitary tumour, a cranio-pharyngioma or a neurinoma. In each case, these treatment plans were optimised and compared with the three other dosimetries. Radiobiological or positioning parameters were evaluated, as well as dosimetric parameters, in order to compare treatments with different characteristics. Results. - The dosimetric parameters showed that the choice of treatment seemed to be determined mostly by tumour size, shape and proximity with organs at risk (not tumour localisation). Whereas the results showed no significant deviations with regards to the radiobiological parameters. Therefore, with these parameters, it was difficult to give priority to a treatment. Conclusions. - With regards to benign brain tumours of medium or large size, intensity modulated radiotherapy seemed the recommended treatment. It enabled to obtain a good ratio between efficacy and toxicity for tumours that are really close to organs at risk. Concerning small benign brain tumours, the CyberKnife{sup R} was probably the best treatment. (authors)

  4. Dosimetric study of tips exposure during preparations and injections of {sup 18}F.D.G. in usual situation and degraded mode; Etude dosimetrique des expositions aux extremites lors des preparations et injections de 18FDG en situation normale et en mode degrade

    Energy Technology Data Exchange (ETDEWEB)

    Halley, A.; Lortal, B.; Dejean, C.; Buj, S.; Bouquey, C.; Clement, R.; Lecamus, S.; Bonichon, F.; Cazeau, A.L.; Caron, J. [Institut Bergonie, 33 - Bordeaux (France)

    2010-07-01

    Purpose: to evaluate tips exposure of manipulators in electro radiology in usual and degraded situation of radiation protection during the preparation and injection of {sup 18}F.D.G. solutions. indeed, during dysfunction of high energy shielded enclosure and/or automatic injector of F.D.G., an operation in manual mode is established. Conclusions: As expected, the phase of manual preparation in case of dysfunction of high energy shielded enclosure is the most irradiating because of possible successive sampling in order to adjust activity to inject. The derivative use of syringe-guard of automatic injector shows its efficiency for manual injection in degraded situation, even if irradiation stay more important comparatively to an automatic injection. (N.C.)

  5. Dosimetric comparison between conformational radio-therapies with or without intensity modulation in the postoperative treatment of retroperitoneal sarcomas; Comparaison dosimetrique entre radio-therapies conformationnelles sans et avec modulation d'intensite dans le traitement postoperatoire des sarcomes retro-peritoneaux

    Energy Technology Data Exchange (ETDEWEB)

    Paumier, A.; Le Pechoux, C.; Negretti, L.; Roberti, E.; Daly-Schweitzer, N. [Departement de radiotherapie, institut Gustave-Roussy, 94 - Villejuif (France); Ferreira, I.; Beaudre, A.; Brahim, J.; Lefkopoulos, D. [Unite de physique, institut Gustave-Roussy, 94 - Villejuif (France); Bonvalot, S. [Departement de chirurgie, institut Gustave-Roussy, 94 - Villejuif (France)

    2010-10-15

    The authors report a study performed on ten patients who had a postoperative radiotherapy. Three treatment plans have been computed (conventional conformational radiotherapy, intensity-modulated conformation radiotherapy or IMRT with 6 or 9 beams). Different parameters have been compared: dose delivered to organs at risk, dose delivered to the whole body, and the conformity index. It appears that IMRT reduces high-dose irradiated volumes, increases low dose irradiation, and also allows the treatment duration to be reduced. Radio-induced cancers and late toxicity are still to be assessed, notably the intestinal and contralateral renal toxicity. Short communication

  6. Study and determination of the national dosimetric standards in terms of air kerma for X-rays radiation fields of low and medium-energies; Etude et realisation des references dosimetriques nationales en termes de kerma dans l'air pour les faisceaux de rayons X de basses et moyennes energies

    Energy Technology Data Exchange (ETDEWEB)

    Ksouri, W

    2008-12-15

    Progress in radiation protection and radiotherapy, and the increased needs in terms of accuracy lead national metrology institutes to improve the standard. For ionizing radiation, the standard is defined by an absolute instrument used for air kerma rate measurement. The aim of the thesis is to establish standards, in terms of air kerma for X-rays beams of low and medium-energies. This work enables to complement the standard beam range of the Laboratoire National Henri Becquerel (LNHB). Two free-air chambers have been developed, WK06 for medium-energy and WK07 for low-energy. The air-kerma rate is corrected by several correction factors. Some are determined experimentally; and the others by using Monte Carlo simulations. The uncertainty budget of the air-kerma rate at one standard deviation has been established. These dosimetric standards were compared with those of counterparts' laboratories and are consistent in terms of degree of equivalence. (author)

  7. Radioinduced pulmonary fibrosis: prospective study of clinical, dosimetric and biological predictive factors after conformal irradiation of non at small cells bronchi carcinomas; Fibroses radiques pulmonaires: etude prospective des facteurs predictifs cliniques, dosimetriques et biologiques apres irradiation conformationnelle des carcinomes bronchiques non a petites cellules

    Energy Technology Data Exchange (ETDEWEB)

    Claude, L.; Ginestet, C.; Martel-Lafay, I.; Carrie, C. [Centre Leon-Berard, 69 - Lyon (France); Etienne-Mastroiani, B. [Hopital Louis-Pradel, 69 - Lyon (France); Arpin, D. [Hopital de la Croix-Rousse, 69 - Lyon (France); Vincent, M. [Hopital Saint-Luc-Saint-Joseph, 69 - Lyon (France); Falchero, L. [Hopital de Villefranche, 69 - Villefranche s/Saone (France); Blay, J.Y. [Hopital Edouard-Herriot, 69 - Lyon (France); Perol, D. [Centre Leon-Berard, 69 - Lyon (France)

    2007-11-15

    This broad prospective study confirms the contribution of dosimetry factors ( pulmonary average dose, V10 to V50) in the predictive part for the delayed radioinduced fibrosis. Contrary to the acute radioinduced pneumopathy, no significant relationship has been underlined between the variations of cytokines and the delayed radioinduced fibrosis risk. (N.C.)

  8. Adaptation of proton total dose with respect to dosimetric parameters within the frame of treatment of skull base or upper cervical spine chordomas; Adaptation de la dose totale de protons en fonction des parametres dosimetriques dans le cadre du traitement des chordomes de la base du crane et du rachis cervical haut

    Energy Technology Data Exchange (ETDEWEB)

    Hemery, C.G.; Mazeron, J.J.; Feuvret, L. [Groupe hospitalier Pitie-Salpetriere (AP-HP), 75 - Paris (France); Calugaru, V.; Bolle, S.; Habrand, J.L.; Datcharty, J.; Alapetite, C.; Dendale, R.; Feuvret, L. [Institut Curie-Centre de protontherapie d' Orsay, 91 (France); Habrand, J.L.; Datcharty, J. [Institut Gustave-Roussy, 94 - Villejuif (France); Noel, G. [Centre Paul-Strauss, 67 - Strasbourg (France)

    2010-10-15

    The authors report the study of the feasibility of a photon-proton irradiation protocol with a dose adaptation with respect to dosimetric factors for patients suffering form a skull base and upper cervical spine chordoma. Sixty patients have been treated between May 2006 and June 2008 with a combination of high energy photons and protons. As five tumours have locally relapsed and one at distance, the authors comment the local control rates, the number of attained cranial nerves, the value of the macroscopic tumour volume, the survival rate without relapse in terms of multifactorial of uni-factorial analysis. Short communication

  9. Comparative study and clinical implementation of two breathing-adapted radiotherapy techniques: dosimetric benefits for lung cancer treatment; Etude comparative et mise en oeuvre clinique de deux systemes de radiotherapie asservie a la respiration: benefice dosimetrique pour le traitement du cancer du poumon

    Energy Technology Data Exchange (ETDEWEB)

    Simon, L.; Giraud, P.; Rosenwald, J.C. [Institut Curie, Dept. de Radiotherapie, 75 - Paris (France); Servois, V. [Institut Curie, Dept. d' Imagerie Medicale, 75 - Paris (France)

    2006-11-15

    Breathing can lead to organ motions up to several centimeters. For radiotherapy of lung, these motions are generally taken into account by adding a specific margin around the target. Thus, treated volumes are often too large to allow for the high-dose values requested for local control. To manage respiratory motion, deep-inspiration breath-hold technique (DIBH) and gated radiotherapy are starting being used clinically. DIBH consists in asking the patient to perform breath-hold during the treatment and the image acquisition, DIBH level being measured by a spirometer. Gated radiotherapy consists in treating the patient at a certain phase of the free breathing. Linac is synchronized with the motion of a marker' located on the patient chest. Planning images are obtained by a four-dimensional CT (4D-CT) using the same marker. We have assessed the value of these two methods. For lung treatment, compared to a standard treatment, toxicity reduction was mainly due to the lung total volume increase.; It is therefore more significant for breath-hold approach. It is also due to the reduction of safety margins, which is similar for both methods. These two techniques, which have specific advantages and drawbacks, are used routinely at Curie Institute for a large proportion of lung patients, but also for some breast, liver or even Hodgkin disease treatments. (author)

  10. Methodology of assessment of the clinical and dosimetric impact of a change of dose calculation algorithm in radiotherapy; Methodologie d'evaluation de l'impact dosimetrique et clinique du changement d'algorithme de calcul de dose en radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Chaikh, A.; Giraud, J.Y.; Balosso, J. [Centre hospitalier universitaire de Grenoble, Grenoble (France)

    2011-10-15

    The authors report the use of five dose calculation algorithms and the comparison of six treatment plans with identical configurations regarding patient, energy, and ballistics. Thirteen tumour locations have been compared (five in lungs, one in oesophagus, one in breast, three in ENT, two in brain, and one in prostate). The methodology is based on a dosimetric criterion (analysis related to the treatment dose, and to dose distribution) and on a statistic criterion. Short communication

  11. Comparison of three dosimetric techniques to take in account lung tumor motion: gating-like technique results lead to advice the use of gating device even in the cases of pre-operative irradiation; Analyse des contraintes dosimetriques obtenues par trois techniques d'irradiation de tumeurs pulmonaires

    Energy Technology Data Exchange (ETDEWEB)

    Beneyton, V.; Billaud, G.; Niederst, C.; Meyer, P.; Schumacher, C.; Karamanoukian, D.; Noel, G. [Centre de lutte contre le cancer Paul-Strauss, Dept. de radiotherapie, 67 - Strasbourg (France); Bourhala, K. [Centre de lutte contre le cancer Paul-Strauss, Dept. de medecine nucleaire, 67 - Strasbourg (France)

    2010-01-15

    Purpose: Comparison of three dosimetric techniques of lung tumor delineation to integrate tumor motion during breathing. Patients and method: Nineteen patients with T1-3N0M0 malignant lung tumor were treated with definitive chemoradiotherapy (14 cases) or pre-surgery chemo radiation. Doses were, respectively, 66 and 46 Gy. CT-scan for delineation was performed during three phases of breathing: free breathing and deep breath-hold inspiration and expiration. G.T.V. (gross tumor volume) was delineated on the three sequences. The classic technique included G.T.V. from the free-breathing sequence plus a C.T.V. (clinical target volume) margin of 5 to 8 mm plus a P.T.V. (planning target volume) margin of 7 to 10 mm (including I.T.V. [internal target volume] margin and set-up margin). The gating-like technique included G.T.V. from the deep breath-hold inspiration sequence plus a C.T.V. margin of 5 to 8 mm plus a P.T.V. margin of 2 mm. The three-volume technique, included G.T.V. as a result of the fusion of G.T.V.s from the three sequences plus a C.T.V. margin of 5 to 8 mm plus a P.T.V. margin of 2 mm. Dosimetry was calculated for the three P.T.V.s, if possible, with the same fields number and position. Dose constraints and rules were imposed to accept dosimetries: firstly spinal cord maximal dose less than 45 Gy, followed by V95 % for P.T.V. greater than or equal to 95 %, and V20 GY{sub Gy} for lung less than or equal to 30 %, V30 GY{sub Gy} for lung less than or equal to 20 %. Results: G.T.V.s were not statistically different between the three methods of delineation. P.T.V.s were significantly lower with the gating-like technique. V95% of the P.T.V. were not different between the three techniques. With the classic-, the gating-like- and the 3-volume techniques, dosimetry was considered as acceptable, respectively in 15, 18 and 15 cases. Comparisons of constraint values showed that the gating-like method gave the best results. In the case of pre-operative management, the gating-like method allowed the best results even for the V95% values. However, in the absence of gating device or without the possibility to use it, the 3-volume method allowed to take into account more precisely the organ motion than the classical technique. Conclusion: The 3-volume method can be done. It is a good method to take into account the organ motions. However, the gating-like method gives the best results leading to propose its use even for pre-operative patients with upper tumors. (authors)

  12. Radiotherapy of breast or left wall and of ganglionary areas including the internal mammary chain: dosimetric comparison of different ballistics; Radiotherapie du sein ou de la paroi gauche et des aires ganglionnaires incluant la chaine mammaire interne: comparaison dosimetrique de differentes balistiques

    Energy Technology Data Exchange (ETDEWEB)

    Regnault de la Mothe, P.; Berger, A.; Bensadoun, R.J. [PRC, 86 - Poitiers (France)

    2010-10-15

    As the irradiation of the mammary chain is still a matter of controversy because of non negligible toxicity risks, the authors report the comparison of three different irradiation ballistics for the breast or left wall as well as for ganglionary areas: short ballistics of internal mammary chains, long ballistics of internal mammary chains, and ballistics in tangential beams. Target volumes and organs at risk have been delineated, and dose-volume histograms have been compared. Short communication

  13. Dosimetry evaluation of the potential exposure bound to uranium and thorium natural accumulation in the sand of some beaches of the Camargue littoral; Evaluations dosimetriques de l'exposition potentielle liee a l'accumulation naturelle d'uranium et de thorium dans les sables de certaines plages du littoral de Camargue

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The aim of this report is the assessment of potential exposure to radioactive sands discovered in 2000 in two points of the coast of the Camargue (East of Beauduc and Espiguette lighthouses), where specific activity can reach up several thousands of Bq.kg{sup -1} for radionuclides of U{sup 238} and Th{sup 232} radioactive families, and environmental dose rate up to ten times of usual natural background. The excess of radioactivity is carried by small particles of sand (apatites and zircons less than 100 {mu}m). First chapter focuses on radioactivity of the coast of the Golfe du lion and of the Camargue, and more particularly on these two points (cartography, measure, radionuclide identification, mineralogical characterization of particles). This chapter concludes the excess of radioactivity is natural; particles come from several massifs of the Rhone basin, transported by the river and re-distributed on the coast. Second chapter focuses on dosimetric assessment, using reasonable scenarios for the frequenting of these sites by persons of the public in one hand, and drawing up the sizing of the sands and their solubility in gastric and intestinal fluids in an other hand. the annual effective dose, carefully calculated, is about 1 mSv, mainly due to external exposure to gamma rays. such a dose, of same levels as the dose received for 17 months of residence in Paris for example, does not involve any particular action. (authors)

  14. Re-evaluation of ‘paradox of mesozooplankton’ in the eastern Arabian Sea based on ship and satellite observations

    Digital Repository Service at National Institute of Oceanography (India)

    Jyothibabu, R.; Madhu, N.V.; Habeebrehman, H.; Jayalakshmy, K.V.; Nair, K.K.C.; Achuthankutty, C.T.

    of copepods inhabiting in the coastal areas actively consume organic detritus as a supplementary nutritional source. Similarly, a model by Parson and Kessler (1986) shows that the initial presence of microzooplankton in fresh water plumes might increase...

  15. Is group membership necessary for understanding generalized prejudice? A re-evaluation of why prejudices are interrelated.

    Science.gov (United States)

    Bergh, Robin; Akrami, Nazar; Sidanius, Jim; Sibley, Chris G

    2016-09-01

    Many scholars have proposed that people who reject one outgroup tend to reject other outgroups. Studies examining a latent factor behind different prejudices (e.g., toward ethnic and sexual minorities) have referred to this as generalized prejudice. Such research has also documented robust relations between latent prejudice factors and basic personality traits. However, targets of generalized prejudice tend to be lower in power and status and thus it remains an open question as to whether generalized prejudice, as traditionally studied, is about devaluing outgroups or devaluing marginalized groups. We present 7 studies, including experiments and national probability samples (N = 9,907 and 4,037) assessing the importance of outgroup devaluation, versus status- or power based devaluations, for understanding the nature of generalized prejudice, and its links to personality. Results show that (a) personality variables do not predict ingroup/outgroup biases in settings where power and status differences are absent, (b) women and overweight people who score high on generalized prejudice devalue their own groups, and (c) personality variables are far more predictive of prejudice toward low-compared with high-status targets. Together, these findings suggest that the personality explanation of prejudice including the generalized prejudice concept is not about ingroups versus outgroups per se, but rather about devaluing marginalized groups. (PsycINFO Database Record

  16. Re-evaluation of the model-free analysis of fast internal motion in proteins using NMR relaxation.

    Science.gov (United States)

    Frederick, Kendra King; Sharp, Kim A; Warischalk, Nicholas; Wand, A Joshua

    2008-09-25

    NMR spin relaxation retains a central role in the characterization of the fast internal motion of proteins and their complexes. Knowledge of the distribution and amplitude of the motion of amino acid side chains is critical for the interpretation of the dynamical proxy for the residual conformational entropy of proteins, which can potentially significantly contribute to the entropy of protein function. A popular treatment of NMR relaxation phenomena in macromolecules dissolved in liquids is the so-called model-free approach of Lipari and Szabo. The robustness of the mode-free approach has recently been strongly criticized and the remarkable range and structural context of the internal motion of proteins, characterized by such NMR relaxation techniques, attributed to artifacts arising from the model-free treatment, particularly with respect to the symmetry of the underlying motion. We develop an objective quantification of both spatial and temporal asymmetry of motion and re-examine the foundation of the model-free treatment. Concerns regarding the robustness of the model-free approach to asymmetric motion appear to be generally unwarranted. The generalized order parameter is robustly recovered. The sensitivity of the model-free treatment to asymmetric motion is restricted to the effective correlation time, which is by definition a normalized quantity and not a true time constant and therefore of much less interest in this context. With renewed confidence in the model-free approach, we then examine the microscopic distribution of side chain motion in the complex between calcium-saturated calmodulin and the calmodulin-binding domain of the endothelial nitric oxide synthase. Deuterium relaxation is used to characterize the motion of methyl groups in the complex. A remarkable range of Lipari-Szabo model-free generalized order parameters are seen with little correlation with basic structural parameters such as the depth of burial. These results are contrasted with the homologous complex with the neuronal nitric oxide synthase calmodulin-binding domain, which has distinctly different thermodynamic origins for high affinity binding. PMID:18759409

  17. Re-evaluation of pulmonary titanium dioxide nanoparticle distribution using the "relative deposition index": Evidence for clearance through microvasculature

    Directory of Open Access Journals (Sweden)

    Gehr Peter

    2007-08-01

    Full Text Available Abstract Background Translocation of nanoparticles (NP from the pulmonary airways into other pulmonary compartments or the systemic circulation is controversially discussed in the literature. In a previous study it was shown that titanium dioxide (TiO2 NP were "distributed in four lung compartments (air-filled spaces, epithelium/endothelium, connective tissue, capillary lumen in correlation with compartment size". It was concluded that particles can move freely between these tissue compartments. To analyze whether the distribution of TiO2 NP in the lungs is really random or shows a preferential targeting we applied a newly developed method for comparing NP distributions. Methods Rat lungs exposed to an aerosol containing TiO2 NP were prepared for light and electron microscopy at 1 h and at 24 h after exposure. Numbers of TiO2 NP associated with each compartment were counted using energy filtering transmission electron microscopy. Compartment size was estimated by unbiased stereology from systematically sampled light micrographs. Numbers of particles were related to compartment size using a relative deposition index and chi-squared analysis. Results Nanoparticle distribution within the four compartments was not random at 1 h or at 24 h after exposure. At 1 h the connective tissue was the preferential target of the particles. At 24 h the NP were preferentially located in the capillary lumen. Conclusion We conclude that TiO2 NP do not move freely between pulmonary tissue compartments, although they can pass from one compartment to another with relative ease. The residence time of NP in each tissue compartment of the respiratory system depends on the compartment and the time after exposure. It is suggested that a small fraction of TiO2 NP are rapidly transported from the airway lumen to the connective tissue and subsequently released into the systemic circulation.

  18. Re-evaluation of antitumor effects of combination chemotherapy with interferon-α and 5-fluorouracil for advanced hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Munechika Enjoji; Shusuke Morizono; Kazuhiro Kotoh; Motoyuki Kohjima; Yuzuru Miyagi; Tsuyoshi Yoshimoto; Makoto Nakamuta

    2005-01-01

    AIM: To evaluate the efficacy of combination chemotherapy with interferon-α (IFNα) and 5-fluorouracil (5-FU) in patients with advanced hepatocellular carcinoma (HCC).METHODS: Twenty-eight HCC patients in advanced stage were enrolled in the study. They were treated with IFNα/5-FU combination chemotherapy. One cycle of therapy lasted for 4 wk. IFNα (3× 106 units) was subcutaneously injected thrice weekly on days 1, 3, and 5 for 3 wk, and 5-FU (500 mg/d) was administered via the proper hepatic artery for 5 consecutive days per week for 3 wk. No drugs were administered during the 4th wk. The effect of combination chemotherapy was evaluated in each patient after every cycle based on the reduction of tumor volume.RESULTS: After the 1st cycle of therapy, 16 patients showed a partial response (PR, 57.1%) but none showed a complete response (CR, 0%). At the end of therapy,the number of patients who showed a CR, PR, or no response (NR) was 1, 10, and 17, respectively. The response rate for therapy (CR+PR) was 21.5%. Biochemical tests before therapy were compared between responsive (CR+PR) and non-responsive (NR) patients, but no significant differences were found for any of the parameters examined, indicating that no reasonable predictors could be identified in our analysis.CONCLUSION: Attempts should be made to discriminate between responders and non-responders by evaluating tumor size after the first cycle of IFNα/5-FU combination chemotherapy. For non-responders, therapy should not proceed to the next cycle, and instead, different combination of anticancer drugs should be explored.

  19. Re-evaluating the green versus red signal in eukaryotes with secondary plastid of red algal origin

    KAUST Repository

    Burki, Fabien

    2012-05-16

    The transition from endosymbiont to organelle in eukaryotic cells involves the transfer of significant numbers of genes to the host genomes, a process known as endosymbiotic gene transfer (EGT). In the case of plastid organelles, EGTs have been shown to leave a footprint in the nuclear genome that can be indicative of ancient photosynthetic activity in present-day plastid-lacking organisms, or even hint at the existence of cryptic plastids. Here,we evaluated the impact of EGTon eukaryote genomes by reanalyzing the recently published EST dataset for Chromera velia, an interesting test case of a photosynthetic alga closely related to apicomplexan parasites. Previously, 513 genes were reported to originate from red and green algae in a 1:1 ratio. In contrast, by manually inspecting newly generated trees indicating putative algal ancestry, we recovered only 51 genes congruent with EGT, of which 23 and 9 were of red and green algal origin, respectively,whereas 19 were ambiguous regarding the algal provenance.Our approach also uncovered 109 genes that branched within a monocot angiosperm clade, most likely representing a contamination. We emphasize the lack of congruence and the subjectivity resulting from independent phylogenomic screens for EGT, which appear to call for extreme caution when drawing conclusions for major evolutionary events. 2012 The Author(s).

  20. Proposed Risk-Informed Seismic Hazard Periodic Reevaluation Methodology for Complying with DOE Order 420.1C

    Energy Technology Data Exchange (ETDEWEB)

    Kammerer, Annie [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    Department of Energy (DOE) nuclear facilities must comply with DOE Order 420.1C Facility Safety, which requires that all such facilities review their natural phenomena hazards (NPH) assessments no less frequently than every ten years. The Order points the reader to Standard DOE-STD-1020-2012. In addition to providing a discussion of the applicable evaluation criteria, the Standard references other documents, including ANSI/ANS-2.29-2008 and NUREG-2117. These documents provide supporting criteria and approaches for evaluating the need to update an existing probabilistic seismic hazard analysis (PSHA). All of the documents are consistent at a high level regarding the general conceptual criteria that should be considered. However, none of the documents provides step-by-step detailed guidance on the required or recommended approach for evaluating the significance of new information and determining whether or not an existing PSHA should be updated. Further, all of the conceptual approaches and criteria given in these documents deal with changes that may have occurred in the knowledge base that might impact the inputs to the PSHA, the calculated hazard itself, or the technical basis for the hazard inputs. Given that the DOE Order is aimed at achieving and assuring the safety of nuclear facilities—which is a function not only of the level of the seismic hazard but also the capacity of the facility to withstand vibratory ground motions—the inclusion of risk information in the evaluation process would appear to be both prudent and in line with the objectives of the Order. The purpose of this white paper is to describe a risk-informed methodology for evaluating the need for an update of an existing PSHA consistent with the DOE Order. While the development of the proposed methodology was undertaken as a result of assessments for specific SDC-3 facilities at Idaho National Laboratory (INL), and it is expected that the application at INL will provide a demonstration of the methodology, there is potential for general applicability to other facilities across the DOE complex. As such, both a general methodology and a specific approach intended for INL are described in this document. The general methodology proposed in this white paper is referred to as the “seismic hazard periodic review methodology,” or SHPRM. It presents a graded approach for SDC-3, SDC-4 and SDC-5 facilities that can be applied in any risk-informed regulatory environment once risk-objectives appropriate for the framework are developed. While the methodology was developed for seismic hazard considerations, it can also be directly applied to other types of natural hazards.

  1. Re-evaluation of normal splitting of the second heart sound in patients with classical left bundle branch block.

    Science.gov (United States)

    Xiao, H B; Faiek, A H; Gibson, D G

    1994-07-01

    To study the mechanism of normal splitting of the second heart sound in patients with classical left bundle branch block, we investigated 43 such patients and 15 normal controls, using electro-, phono- and echo-cardiography and comparing the relative timing of mechanical activity in the two ventricles. The splitting of the second heart sound is reversed in only two-thirds of the patients and normal in remaining one-third. Comparing patients with and without reversed splitting, there are no significant differences in left ventricular cavity size, heart rate, pre-ejection period and the distribution of age, gender, or aetiology. QRS duration is longer (P < 0.01) in patients with reversed splitting. Diastolic events of the left ventricle do not differ between groups. The onset of the left ventricular free wall motion is delayed compared with normal by a similar extent in the two groups. In patients with normal splitting, the onset of the right ventricular wall motion is also delayed, both with respect to normal and to those with reversed splitting to an extent similar to that seen in classical right bundle branch block. Normal splitting of the second heart sound associated with an electrocardiographic pattern of left bundle branch block therefore suggests bilateral block. This combination can be documented from the precise timing of the movement of the two ventricles by M-mode echocardiography and identified by simple auscultation. PMID:7960260

  2. A re-evaluation of the size of the white shark (Carcharodon carcharias population off California, USA.

    Directory of Open Access Journals (Sweden)

    George H Burgess

    Full Text Available White sharks are highly migratory and segregate by sex, age and size. Unlike marine mammals, they neither surface to breathe nor frequent haul-out sites, hindering generation of abundance data required to estimate population size. A recent tag-recapture study used photographic identifications of white sharks at two aggregation sites to estimate abundance in "central California" at 219 mature and sub-adult individuals. They concluded this represented approximately one-half of the total abundance of mature and sub-adult sharks in the entire eastern North Pacific Ocean (ENP. This low estimate generated great concern within the conservation community, prompting petitions for governmental endangered species designations. We critically examine that study and find violations of model assumptions that, when considered in total, lead to population underestimates. We also use a Bayesian mixture model to demonstrate that the inclusion of transient sharks, characteristic of white shark aggregation sites, would substantially increase abundance estimates for the adults and sub-adults in the surveyed sub-population. Using a dataset obtained from the same sampling locations and widely accepted demographic methodology, our analysis indicates a minimum all-life stages population size of >2000 individuals in the California subpopulation is required to account for the number and size range of individual sharks observed at the two sampled sites. Even accounting for methodological and conceptual biases, an extrapolation of these data to estimate the white shark population size throughout the ENP is inappropriate. The true ENP white shark population size is likely several-fold greater as both our study and the original published estimate exclude non-aggregating sharks and those that independently aggregate at other important ENP sites. Accurately estimating the central California and ENP white shark population size requires methodologies that account for biases introduced by sampling a limited number of sites and that account for all life history stages across the species' range of habitats.

  3. A re-evaluation of the size of the white shark (Carcharodon carcharias) population off California, USA.

    Science.gov (United States)

    Burgess, George H; Bruce, Barry D; Cailliet, Gregor M; Goldman, Kenneth J; Grubbs, R Dean; Lowe, Christopher G; MacNeil, M Aaron; Mollet, Henry F; Weng, Kevin C; O'Sullivan, John B

    2014-01-01

    White sharks are highly migratory and segregate by sex, age and size. Unlike marine mammals, they neither surface to breathe nor frequent haul-out sites, hindering generation of abundance data required to estimate population size. A recent tag-recapture study used photographic identifications of white sharks at two aggregation sites to estimate abundance in "central California" at 219 mature and sub-adult individuals. They concluded this represented approximately one-half of the total abundance of mature and sub-adult sharks in the entire eastern North Pacific Ocean (ENP). This low estimate generated great concern within the conservation community, prompting petitions for governmental endangered species designations. We critically examine that study and find violations of model assumptions that, when considered in total, lead to population underestimates. We also use a Bayesian mixture model to demonstrate that the inclusion of transient sharks, characteristic of white shark aggregation sites, would substantially increase abundance estimates for the adults and sub-adults in the surveyed sub-population. Using a dataset obtained from the same sampling locations and widely accepted demographic methodology, our analysis indicates a minimum all-life stages population size of >2000 individuals in the California subpopulation is required to account for the number and size range of individual sharks observed at the two sampled sites. Even accounting for methodological and conceptual biases, an extrapolation of these data to estimate the white shark population size throughout the ENP is inappropriate. The true ENP white shark population size is likely several-fold greater as both our study and the original published estimate exclude non-aggregating sharks and those that independently aggregate at other important ENP sites. Accurately estimating the central California and ENP white shark population size requires methodologies that account for biases introduced by sampling a limited number of sites and that account for all life history stages across the species' range of habitats. PMID:24932483

  4. A Re-Evaluation of the Size of the White Shark (Carcharodon carcharias) Population off California, USA

    OpenAIRE

    Burgess, George H; Barry D Bruce; Cailliet, Gregor M.; Goldman, Kenneth J.; Dean Grubbs, R.; Lowe, Christopher G.; M Aaron MacNeil; Mollet, Henry F.; Weng, Kevin C.; John B O'Sullivan

    2014-01-01

    White sharks are highly migratory and segregate by sex, age and size. Unlike marine mammals, they neither surface to breathe nor frequent haul-out sites, hindering generation of abundance data required to estimate population size. A recent tag-recapture study used photographic identifications of white sharks at two aggregation sites to estimate abundance in "central California" at 219 mature and sub-adult individuals. They concluded this represented approximately one-half of the total abundan...

  5. Reevaluation of Acromegalic Patients in Long-Term Remission according to Newly Proposed Consensus Criteria for Control of Disease

    Directory of Open Access Journals (Sweden)

    Elisa Verrua

    2014-01-01

    Full Text Available Acromegaly guidelines updated in 2010 revisited criteria of disease control: if applied, it is likely that a percentage of patients previously considered as cured might present postglucose GH nadir levels not adequately suppressed, with potential implications on management. This study explored GH secretion, as well as hormonal, clinical, neuroradiological, metabolic, and comorbid profile in a cohort of 40 acromegalic patients considered cured on the basis of the previous guidelines after a mean follow-up period of 17.2 years from remission, in order to assess the impact of the current criteria. At the last follow-up visit, in the presence of normal IGF-I concentrations, postglucose GH nadir was over 0.4 μg/L in 11 patients (Group A and below 0.4 μg/L in 29 patients (Group B; moreover, Group A showed higher basal GH levels than Group B, whereas a significant decline of both GH and postglucose GH nadir levels during the follow-up was observed in Group B only. No differences in other evaluated parameters were found. These results seem to suggest that acromegalic patients considered cured on the basis of previous guidelines do not need a more intensive monitoring than patients who met the current criteria of disease control, supporting instead that the cut-off of 0.4 mcg/L might be too low for the currently used GH assay.

  6. [Re-evaluation of the epistemic foundation of Baglivi's medical doctrine and his anatomico-physiological theory].

    Science.gov (United States)

    Mihalić, Neva G

    2009-01-01

    Gjuro Baglivi (1668-1707) is a Croatian medical doctor and natural philosopher who realised a relevant scientific career and an European fame during the time of scientific revolution, having worked in Rome as an associate and personal secretary of M. Malpighi, as a personal doctor of two popes and teaching medicine at the Sapienza University. Baglivi's life and works have been investigated thoroughly due to their historical and medical history aspects but his other scientific and philosophical views were touched upon only in principle. From the history and philosophy of science perspective I investigated the epistemic foundations of Baglivi's medical praxis and his anatomico-physiological theory as they were the results not only of his medical knowledge, medical practice and anatomical observations but they emerged from Baglivi's conceptualization of structure and function of human body in the context of natural history and, respectively, natural philosophy of that time. Baglivi wanted to establish medicine on experimental and empirical foundations and to point to the object and the purpose of medical study--the human body. By doing this, and despite being a proponent of iatrophysics, Baglivi clearly separated medicine from physical and mathematical sciences which flourished in the 16th and 17th century. As they were derivated with great cautiousness in philosophysing from his empirical observations and experiments, even in the faulty explanations Baglivi's conceptions hide an analyticaly correct cognitive flair.

  7. Reevaluation of ANS binding to human and bovine serum albumins: key role of equilibrium microdialysis in ligand - receptor binding characterization.

    Directory of Open Access Journals (Sweden)

    Irina M Kuznetsova

    Full Text Available In this work we return to the problem of the determination of ligand-receptor binding stoichiometry and binding constants. In many cases the ligand is a fluorescent dye which has low fluorescence quantum yield in free state but forms highly fluorescent complex with target receptor. That is why many researchers use dye fluorescence for determination of its binding parameters with receptor, but they leave out of account that fluorescence intensity is proportional to the part of the light absorbed by the solution rather than to the concentration of bound dye. We showed how ligand-receptor binding parameters can be determined by spectrophotometry of the solutions prepared by equilibrium microdialysis. We determined the binding parameters of ANS - human serum albumin (HSA and ANS - bovine serum albumin (BSA interaction, absorption spectra, concentration and molar extinction coefficient, as well as fluorescence quantum yield of the bound dye. It was found that HSA and BSA have two binding modes with significantly different affinity to ANS. Correct determination of the binding parameters of ligand-receptor interaction is important for fundamental investigations and practical aspects of molecule medicine and pharmaceutics. The data obtained for albumins are important in connection with their role as drugs transporters.

  8. The multidimensional driving style inventory a decade later: Review of the literature and re-evaluation of the scale.

    Science.gov (United States)

    Taubman-Ben-Ari, Orit; Skvirsky, Vera

    2016-08-01

    The Multidimensional Driving Style Inventory (MDSI; Taubman - Ben-Ari, Mikulincer, & Gillath, 2004a), a self-report questionnaire assessing four broad driving styles, has been in use for the last ten years. During that time, numerous studies have explored the associations between the MDSI factors and sociodemographic and driving-related variables. The current paper employs two large data sets to summarize the accumulated knowledge, examining MDSI factors in samples of young drivers aged 17-21 (Study 1, n=1436) and older drivers aged 22-84 (Study 2, n=3409). Findings indicate that driving-related indicators are coherently and systematically related to the four driving styles in the expected directions, revalidating the structure of the MDSI. The results also help clarify the relationships between the driving styles and variables such as gender, ethnicity, car ownership, age, and experience, and suggest that driving styles are largely unaffected by sociodemographic characteristics, except for gender and ethnicity, and appear to represent a relatively stable and universal trait. The two studies highlight the validity and reliability of the MDSI, attesting to its practical value as a tool for purposes of research, evaluation, and intervention. PMID:27208590

  9. Re-evaluation of the mechanisms of dietary fibre and implications for macronutrient bioaccessibility, digestion and postprandial metabolism.

    Science.gov (United States)

    Grundy, Myriam M-L; Edwards, Cathrina H; Mackie, Alan R; Gidley, Michael J; Butterworth, Peter J; Ellis, Peter R

    2016-09-01

    The positive effects of dietary fibre on health are now widely recognised; however, our understanding of the mechanisms involved in producing such benefits remains unclear. There are even uncertainties about how dietary fibre in plant foods should be defined and analysed. This review attempts to clarify the confusion regarding the mechanisms of action of dietary fibre and deals with current knowledge on the wide variety of dietary fibre materials, comprising mainly of NSP that are not digested by enzymes of the gastrointestinal (GI) tract. These non-digestible materials range from intact cell walls of plant tissues to individual polysaccharide solutions often used in mechanistic studies. We discuss how the structure and properties of fibre are affected during food processing and how this can impact on nutrient digestibility. Dietary fibre can have multiple effects on GI function, including GI transit time and increased digesta viscosity, thereby affecting flow and mixing behaviour. Moreover, cell wall encapsulation influences macronutrient digestibility through limited access to digestive enzymes and/or substrate and product release. Moreover, encapsulation of starch can limit the extent of gelatinisation during hydrothermal processing of plant foods. Emphasis is placed on the effects of diverse forms of fibre on rates and extents of starch and lipid digestion, and how it is important that a better understanding of such interactions with respect to the physiology and biochemistry of digestion is needed. In conclusion, we point to areas of further investigation that are expected to contribute to realisation of the full potential of dietary fibre on health and well-being of humans. PMID:27385119

  10. Re-evaluation of the conodont Iapetognathus and implications for the base of the Ordovician System GSSP

    DEFF Research Database (Denmark)

    Terfelt, Fredrik; Bagnoli, Gabriella; Stouge, Svend

    2012-01-01

    . A redefinition of the GSSP horizon is suggested. The following four alternative horizons have potential as new horizons for the GSSP level: the FAD of Cordylodus intermedius; the FAD of Cordylodus andresi; the FAD of Eoconodontus notchpeakensis; and the FAD of the agnostoid Lotagnostus americanus. □Boundary...

  11. A taxonomic reevaluation of Phrynops (Testudines: Chelidae) with the description of two new genera and a new species of Batrachemys.

    Science.gov (United States)

    McCord, W P; Joseph-Ouni, M; Lamar, W W

    2001-06-01

    Relationships among turtle species loosely categorized within the South American genus Phrynops are explored. Three once recognized genera (Batrachemys, Mesoclemmys and Phrynops) that were demoted to subgenera, and then synonymized with Phrynops, are demonstrated to warrant full recognition based on morphometric analysis, skull osteology, and mitochondrial and nuclear gene sequencing. Mesoclemmys is resurrected from the synonymy of Phrynops as a monotypic genus including M. gibba. The genus Rhinemys, previously a synonym of Phrynops, is resurrected for the species R. rufipes. Ranacephala gen. nov. is described to include the species R. hogei. The genus Batrachemys is resurrected from the synonymy of Phrynops and includes B. dahli, B. nasuta, B. raniceps, B. tuberculata, and B. zuliae. The taxon vanderhaegei is placed in Bufocephala gen. nov. The genus Phrynops is redefined to include the taxa P. geoffroanus, P. hilarii, P. tuberosus, and P. williamsi. Cladistic analysis of morphological data supports this taxonomy. A new species of Batrachemys is described from the western Amazon region, and is distinguished by having facial markings in juveniles, a relatively wide head, and a flattened shell. The new species, B. heliostemma sp. nov., is sympatric with and most similar to the recently resurrected form Batrachemys raniceps in the upper Amazonian region of Peru and adjacent Brazil, Ecuador, Venezuela, and Colombia. Lastly, morphometric data from living and museum specimens of all species of Batrachemys are presented. PMID:11935927

  12. High resolution optical spectroscopy in isotopically-pure Si using radioactive isotopes: towards a re-evaluation of deep centres

    CERN Multimedia

    2008-01-01

    Deep centres in silicon have been studied in great detail over the last 50 years and much progress has been made in the understanding and control of impurities in this material. Much of this effort has been focussed on the problems of metallic impurities such as Fe, Ag, Cu and Au. These are impurities that diffuse quickly into the crystal and hamper device performance. Although the understanding of these impurity centres in Si is widely thought to be "solved" recent experiments with isotopically-pure Si are disproving long-held results and are opening up new perspectives on the constitutent nature of deep centres in Si. In particular, there is new evidence to show that the family of Cu, Ag and Au may all show essentially the same behaviour by forming a cluster of $\\textbf{any four atoms}$ of these elements. This has been established for Cu and Ag through the use of different stable isotopes in the preparation of samples, but the case of Au remains unproven since there is only one stable Au isotope. In this pr...

  13. In vivo nuclear magnetic resonance studies of hepatic methoxyflurane metabolism. II. A reevaluation of hepatic metabolic pathways.

    Science.gov (United States)

    Selinsky, B S; Perlman, M E; London, R E

    1988-05-01

    Methoxyflurane (2,2-dichloro-1,1-difluoro-ethyl methyl ether) is believed to be metabolized via two convergent metabolic pathways. The relative flux through these two metabolic pathways has been investigated using a combination of in vivo surface coil NMR techniques and in vitro analyses of urinary metabolites. Analysis of the measured concentrations of inorganic fluoride, oxalate, and methoxydifluoroacetate in the urine of methoxyflurane-treated rats for 4 days after anesthesia indicates that the anesthetic is metabolized primarily via dechlorination to yield methoxydifluoroacetate. The methoxydifluoroacetate is largely excreted without further metabolism, although a small percentage of this metabolite is broken down to yield fluoride and oxalate, as determined by urine analysis of rats dosed with synthetic methoxydifluoroacetate. At early times after methoxyflurane exposure, the relative concentrations of methoxyflurane metabolites indicate that a significant fraction of the metabolic flux occurs via a different pathway, presumably demethylation, to yield dichloroacetate as an intermediate. Direct analysis of dichloroacetate in the urine using water-suppressed proton NMR indicates that the level of this metabolite is below the detection threshold of the method. Measurements made on the urine of rats dosed directly with dichloroacetate indicate that this compound is quickly metabolized, and dichloroacetate levels in urine are again found to be below the detection threshold. These results demonstrate the quantitative importance of the dechlorination pathway in the metabolism of methoxyflurane in rats. PMID:3367904

  14. Steacyite, a new name, and a re-evaluation of the nomenclature of 'ekanite'-group minerals

    International Nuclear Information System (INIS)

    Ekanite from the type locality (Sri Lanka), ThCa2Si8O20, is metamict and gives only a very poor Debye-Scherrer diagram; heated Sri Lanka ekanite is body-centred tetragonal, with a 7.46, c 14.96 A. Natural ekanite from the Tombstone Mountains, Yukon Territory (Symanski et al. 1982) has the same chemical composition and gives a powder pattern that matches that of heated ekanite from Sri Lanka. The crystal structure of ekanite is characterized by Si8O20 sheets, space group I422, a 7.483(3), c 14.893(6) A. Steacyite corresponds to Th(Na,Ca)sub(2)(Ksub(1-) blocksub(z))Sisub(8)0sub(20), z = 0.39, described by Perrault β Richard (1973) under the name 'ekanite'. The crystal structure of steacyite is characterized by discrete pseudocubic arrangments of Si8O20, space group P4/mcc, a 7.58(1), c 14.77(2) A, Z=2. Powder diagrams of ekanite and steacyite show significant diffrences. A Th-Ca-K silicate from central Asia was described by Ginzburg et al. (1965) under the name 'ekanite'; it corresponds to Th(Ca,Na)sub( 2)(Ksub(1-z)blocksub(z)) Sisub(8)Osub(20) with z between 0.23 and 0.40. Space group, cell dimensions and powder pattern are essentially identical to those of steacyite; this mineral should receive a name other than ekanite. These two minerals may define a continuous series. The name honours H.R. Steacy of the Geological Survey of Canada. Iraqite (Livingston et al. 1976) gives a powder pattern identical to that of steacyite and is presumed isotructural. It corresponds to (RE,Th)Casub(2)(Ksub(1-z)blocksub(z)) Sisub(8)0sub(20), with z = 0.47

  15. Re-evaluating the Rose approach: comparative benefits of the population and high-risk preventive strategies.

    LENUS (Irish Health Repository)

    Cooney, Marie-Therese

    2009-10-01

    Options for the prevention of cardiovascular disease, the greatest global cause of death, include population preventive measures (the Rose approach), or specifically seeking out and managing high-risk cases. However, the likely benefit of a population approach has been recently questioned.

  16. Re-evaluating the Rose approach: comparative benefits of the population and high-risk preventive strategies

    DEFF Research Database (Denmark)

    Cooney, Marie-Therese; Dudina, Alexandra; Whincup, Peter;

    2009-01-01

    BACKGROUND: Options for the prevention of cardiovascular disease, the greatest global cause of death, include population preventive measures (the Rose approach), or specifically seeking out and managing high-risk cases. However, the likely benefit of a population approach has been recently...... (SCORE risk) before and after the particular intervention. Risk factors studied were: total cholesterol, blood pressure and smoking. RESULTS: At population level, if a 10-year reduction of blood cholesterol level of 10%, a BP reduction of 10% and a 10% reduction in the prevalence of smoking is considered...

  17. A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?

    Science.gov (United States)

    Herbert, Terence P; Laybutt, D Ross

    2016-06-01

    Endoplasmic reticulum (ER) stress caused by perturbations in ER homeostasis activates an adaptive response termed the unfolded protein response (UPR) whose function is to resolve ER stress. If unsuccessful, the UPR initiates a proapoptotic program to eliminate the malfunctioning cells from the organism. It is the activation of this proapoptotic UPR in pancreatic β-cells that has been implicated in the onset of type 2 diabetes and thus, in this context, is considered a maladaptive response. However, there is growing evidence that β-cell death in type 2 diabetes may not be caused by a maladaptive UPR but by the inhibition of the adaptive UPR. In this review, we discuss the evidence for a role of the UPR in β-cell dysfunction and death in the development of type 2 diabetes and ask the following question: Is β-cell dysfunction the result of a maladaptive UPR or a failure of the UPR to adequately adapt? The answer to this question is critically important in defining potential therapeutic strategies for the treatment and prevention of type 2 diabetes. In addition, we discuss the potential role of the adaptive UPR in staving off type 2 diabetes by enhancing β-cell mass and function in response to insulin resistance. PMID:27222391

  18. Re-evaluation of Magnetic Resonance and Computerised Tomographic Imaging in Neuro-Ophthalmic Patients in an Academic Centre

    NARCIS (Netherlands)

    Koekoek, Clarence G. J.; Meiners, Linda C.; Pott, Jan Willem R.

    2012-01-01

    The aim of the study is to report the frequency of missed diagnoses on magnetic resonance and computerised tomographic imaging in neuro-ophthalmic patients who were referred to an academic ophthalmology department, with apparent normal imaging. The authors included all neuro-ophthalmic patients, ref

  19. A re-evaluation of life-long severe galactose restriction for the nutrition management of classic galactosemia.

    Science.gov (United States)

    Van Calcar, Sandra C; Bernstein, Laurie E; Rohr, Frances J; Scaman, Christine H; Yannicelli, Steven; Berry, Gerard T

    2014-07-01

    The galactose-restricted diet is life-saving for infants with classic galactosemia. However, the benefit and extent of dietary galactose restriction required after infancy remain unclear and variation exists in practice. There is a need for evidence-based recommendations to better standardize treatment for this disorder. This paper reviews the association between diet treatment and outcomes in classic galactosemia and evaluates the contribution of food sources of free galactose in the diet. Recommendations include allowing all fruits, vegetables, legumes, soy products that are not fermented, various aged cheeses and foods containing caseinates. Further research directions are discussed. PMID:24857409

  20. Dawsonite synthesis and reevaluation of its thermodynamic properties from solubility measurements: Implications for mineral trapping of CO 2

    Science.gov (United States)

    Bénézeth, Pascale; Palmer, Donald A.; Anovitz, Lawrence M.; Horita, Juske

    2007-09-01

    Over the last decade, a significant research effort has focused on determining the feasibility of sequestering large amounts of CO 2 in deep, permeable geologic formations to reduce carbon dioxide emissions to the atmosphere. Most models indicate that injection of CO 2 into deep sedimentary formations will lead to the formation of various carbonate minerals, including the common phases calcite (CaCO 3), dolomite (CaMg(CO 3) 2), magnesite (MgCO 3), siderite (FeCO 3), as well as the far less common mineral, dawsonite (NaAlCO 3(OH) 2). Nevertheless, the equilibrium and kinetics that control the precipitation of stable carbonate minerals are poorly understood and few experiments have been performed to validate computer codes that model CO 2 sequestration. In order to reduce this uncertainty we measured the solubility of synthetic dawsonite according to the equilibrium: NaAlCO(OH)+2HO⇌Al(OH)4-+HCO3-+Na+H, from under- and oversaturated solutions at 50-200 °C in basic media at 1.0 mol · kg -1 NaCl. The solubility products ( Qs) obtained were extrapolated to infinite dilution to obtain the solubility constants ( Kso). Combining the fit of these logKso values and fixing ΔCp,roat-185.5J·mol·K-1 at 25 °C, which was derived from the calorimetric data of Ferrante et al. [Ferrante, M.J., Stuve, J.M., and Richardson, D.W., 1976. Thermodynamic data for synthetic dawsonite. U.S. Bureau of Mines Report Investigation, 8129, Washington, D.C., 13p.], the following thermodynamic parameters for the dissolution of dawsonite were calculated at 25 °C: ΔGro=102.1kJ·mol, ΔHro=97.0kJ·mol and ΔSro=-17.1J·mol·K-1. Subsequently, we were able to derive values for the Gibbs energy of formation ( ΔfG298.15o=-1782±2kJ·mol), enthalpy of formation ( ΔfH298.15o=-1960±7kJ·mol) and entropy ( S298.15o=131±2J·mol·K-1) of dawsonite. These results are within the combined experimental uncertainties of the values reported by Ferrante et al. (1976). Predominance diagrams are presented for the dawsonite/boehmite and dawsonite/bayerite equilibria at 100 °C in the presence of a saline solution with and without silica-containing minerals.

  1. Re-evaluation of low intensity pulsed ultrasound in treatment of tibial fractures (TRUST): randomized clinical trial

    Science.gov (United States)

    Bhandari, Mohit; Einhorn, Thomas A; Schemitsch, Emil; Heckman, James D; Tornetta, Paul; Leung, Kwok-Sui; Heels-Ansdell, Diane; Makosso-Kallyth, Sun; Della Rocca, Gregory J; Jones, Clifford B; Guyatt, Gordon H

    2016-01-01

    Objective To determine whether low intensity pulsed ultrasound (LIPUS), compared with sham treatment, accelerates functional recovery and radiographic healing in patients with operatively managed tibial fractures. Design A concealed, randomized, blinded, sham controlled clinical trial with a parallel group design of 501 patients, enrolled between October 2008 and September 2012, and followed for one year. Setting 43 North American academic trauma centers. Participants Skeletally mature men or women with an open or closed tibial fracture amenable to intramedullary nail fixation. Exclusions comprised pilon fractures, tibial shaft fractures that extended into the joint and required reduction, pathological fractures, bilateral tibial fractures, segmental fractures, spiral fractures >7.5 cm in length, concomitant injuries that were likely to impair function for at least as long as the patient’s tibial fracture, and tibial fractures that showed 1 cm gap after surgical fixation. 3105 consecutive patients who underwent intramedullary nailing for tibial fracture were assessed, 599 were eligible and 501 provided informed consent and were enrolled. Interventions Patients were allocated centrally to self administer daily LIPUS (n=250) or use a sham device (n=251) until their tibial fracture showed radiographic healing or until one year after intramedullary fixation. Main outcome measures Primary registry specified outcome was time to radiographic healing within one year of fixation; secondary outcome was rate of non-union. Additional protocol specified outcomes included short form-36 (SF-36) physical component summary (PCS) scores, return to work, return to household activities, return to ≥80% of function before injury, return to leisure activities, time to full weight bearing, scores on the health utilities index (mark 3), and adverse events related to the device. Results SF-36 PCS data were acquired from 481/501 (96%) patients, for whom we had 2303/2886 (80%) observations, and radiographic healing data were acquired from 482/501 (96%) patients, of whom 82 were censored. Results showed no impact on SF-36 PCS scores between LIPUS and control groups (mean difference 0.55, 95% confidence interval −0.75 to 1.84; P=0.41) or for the interaction between time and treatment (P=0.30); minimal important difference is 3-5 points) or in other functional measures. There was also no difference in time to radiographic healing (hazard ratio 1.07, 95% confidence interval 0.86 to 1.34; P=0.55). There were no differences in safety outcomes between treatment groups. Patient compliance was moderate; 73% of patients administered ≥50% of all recommended treatments. Conclusions Postoperative use of LIPUS after tibial fracture fixation does not accelerate radiographic healing and fails to improve functional recovery. Study registration ClinicalTrialGov Identifier: NCT00667849

  2. Organic Matter in SNC Meteorites: Is It Time to Re-Evaluate the Viking Biology Experimental Data?

    Science.gov (United States)

    Warmflash, D.; Clemett, S. J.; McKay, D. S.

    2001-01-01

    New data from SNC meteorites suggests that organic material may be present in the martian upper crust. This adds to possibility that the Viking biology experiments may have plausible biological interpretations as well as inorganic chemical interpretations Additional information is contained in the original extended abstract..

  3. Poor Tc-99m dimercaptosuccinic acid uptake, re-evaluation with Tc-99m MAG3 scintigraphy in Lowe syndrome

    Science.gov (United States)

    Koca, Gokhan; Atilgan, Hasan Ikbal; Demirel, Koray; Diri, Akif; Korkmaz, Meliha

    2011-01-01

    Tc-99m dimercaptosuccinic acid (DMSA) is filtered through the glomeruli and reabsorbed by the proximal tubules as low molecular weight proteins. In Lowe syndrome this mechanism is impaired and so poor DMSA uptake is seen. Poor DMSA uptake was shown in very few studies, but none mentioned normal Tc-99m MAG3 uptake. In this case, the patient had poor DMSA uptake, normal MAG3 uptake and a neurogenic bladder in anterior to the left kidney that attenuates left kidney. PMID:23559713

  4. A reevaluation of the Pallett Creek earthquake chronology based on new AMS radiocarbon dates, San Andreas fault, California

    Science.gov (United States)

    Scharer, K.M.; Biasi, G.P.; Weldon, R.J.

    2011-01-01

    The Pallett Creek paleoseismic record occupies a keystone position in most attempts to develop rupture histories for the southern San Andreas fault. Previous estimates of earthquake ages at Pallett Creek were determined by decay counting radiocarbon methods. That method requires large samples which can lead to unaccounted sources of uncertainty in radiocarbon ages because of the heterogeneous composition of organic layers. In contrast, accelerator mass spectrometry (AMS) radiocarbon dates may be obtained from small samples that have known carbon sources and also allow for a more complete sampling of the section. We present 65 new AMS radiocarbon dates that span nine ground-rupturing earthquakes at Pallett Creek. Overall, the AMS dates are similar to and reveal no dramatic bias in the conventional dates. For many layers, however, individual charcoal samples were younger than the conventional dates, leading to earthquake ages that are overall slightly younger than previously reported. New earthquake ages are determined by Bayesian refinement of the layer ages based on stratigraphic ordering and sedimentological constraints. The new chronology is more regular than previously published records in large part due to new samples constraining the age of event R. The closed interval from event C to 1857 has a mean recurrence of 135years (?? = 83.2 years) and a quasiperiodic coefficient of variation (COV) of 0.61. We show that the new dates and resultant earthquake chronology have a stronger effect on COV than the specific membership of this long series and dating precision improvements from sedimentation rates. Copyright 2011 by the American Geophysical Union.

  5. Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF)

    DEFF Research Database (Denmark)

    Croll, Tristan Ian; Andersen, Gregers Rom

    2016-01-01

    interactive molecular-dynamics flexible fitting (iMDFF) approach significantly reduces the complexity of the conformational space to be searched during manual rebuilding. This substantially improves the rate of detection and correction of register errors, and allows user-guided model building in maps...... density. With current model-building tools this task can be challenging, and the de facto standard for acceptable error rates (in the form of atomic clashes and unfavourable backbone and side-chain conformations) in structures based on data with dmax not exceeding 3.5 Å reflects this. When combined...

  6. Advances in the pathogenesis of Alzheimer’s disease: a re-evaluation of amyloid cascade hypothesis

    Directory of Open Access Journals (Sweden)

    Dong Suzhen

    2012-09-01

    Full Text Available Abstract Alzheimer’s disease (AD is a common neurodegenerative disease characterized clinically by progressive deterioration of memory, and pathologically by histopathological changes including extracellular deposits of amyloid-beta (A-beta peptides forming senile plaques (SP and the intracellular neurofibrillary tangles (NFT of hyperphosphorylated tau in the brain. This review focused on the new developments of amyloid cascade hypothesis with details on the production, metabolism and clearance of A-beta, and the key roles of some important A-beta-related genes in the pathological processes of AD. The most recent research advances in genetics, neuropathology and pathogenesis of the disease were also discussed.

  7. Future directions in combined modality therapy for rectal cancer: reevaluating the role of total mesorectal excision after chemoradiotherapy

    Directory of Open Access Journals (Sweden)

    Solanki AA

    2013-08-01

    Full Text Available Abhishek A Solanki,1 Daniel T Chang,2 Stanley L Liauw11Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA; 2Department of Radiation Oncology, Stanford University, Stanford, CA, USAAbstract: Most patients who develop rectal cancer present with locoregionally advanced (T3 or node-positive disease. The standard management of locoregionally advanced rectal cancer is neoadjuvant concurrent chemoradiotherapy (nCRT, followed by radical resection (low-anterior resection or abdominoperineal resection with total mesorectal excision. Approximately 15% of patients can have a pathologic complete response (pCR at the time of surgery, indicating that some patients can have no detectable residual disease after nCRT. The actual benefit of surgery in this group of patients is unclear. It is possible that omission of surgery in these patients, termed selective nonoperative management, can limit the toxicities associated with standard, multimodal combined modality therapy without compromising disease control. In this review, we discuss the clinical experiences to date using selective nonoperative management and various attempts at escalation of nCRT to improve the number of patients who have a pCR. We also explore several clinical, laboratory, imaging, histopathologic, and genetic biomarkers that have been tested as tools to predict which patients are most likely to have a pCR after nCRT.Keywords: rectal cancer, chemoradiotherapy, total mesorectal excision, nonoperative management, organ preservation

  8. Re-evaluation of groundwater monitoring data for glyphosate and bentazone by taking detection limits into account

    DEFF Research Database (Denmark)

    Hansen, Claus Toni; Ritz, Christian; Gerhard, Daniel;

    2015-01-01

    .e. samples with concentrations below the detection limit, as left-censored observations. The median calculated pesticide concentrations are shown to be reduced 10(4) to 10(5) fold for two representative herbicides (glyphosate and bentazone) relative to the median concentrations based upon observations above...

  9. Re-evaluating the taxonomic status of Chiromantis in Thailand using multiple lines of evidence (Amphibia: Anura: Rhacophoridae).

    Science.gov (United States)

    Aowphol, Anchalee; Rujirawan, Attapol; Taksintum, Wut; Arsirapot, Sutipong; McLeod, David S

    2013-01-01

    Because of general phenotypic similarities and distribution of species across two continents, the genus Chiromantis has proven somewhat enigmatic. Among Indochinese species, the validity of C. hansenae has been questioned by some who consider it a junior synonym of C. vittatus. We employ three lines of evidence to elucidate the taxonomic status and phylogenetic relationships of four congeneric species of Chiromantis frogs from Thailand. Results of molecular, morphological, and bioacoustic data analyses support at least four evolutionarily distinct and monophyletic clades: C. doriae, C. nongkhorensis, C. vittatus and C. hansenae. Genetic divergence between C. vittatus and C. hansenae is > 10%, significantly greater than C. doriae and C nongkhorensis (4.5%). Our results support the taxonomic validity of C. hansenae and suggest that there may be more diversity within C. hansenae and C. vittatus than is currently recognized. PMID:26146711

  10. The genomic relationship between cultivated sorghum [Sorghum bicolor (L.) Moench] and Johnsongrass [S. halepense (L.) Pers.]: a re-evaluation.

    Science.gov (United States)

    Hoang-Tang; Liang, G H

    1988-08-01

    The genomic relationship between cultivated sorghum [Sorghum bicolar (L.) Moench, race bicolor, De Wet, 2n=20] and Johnsongrass [S. halepense (L.) Pers., 2n=40] has been a subject of extensive studies. Nevertheless, there is no general consensus concerning the ploidy level and the number of genomes present in the two species. This research tested the validity of four major genomic models that have been proposed previously for the two species by studying chromosome behaviors in the parental species, 30-chromosome hybrids [sorghum, (2n=20) x Johnsongrass, (2n=40)], 40-chromosome hybrids [sorghum, (2n=40) x Johnsongrass, (2n=40)] and 60-chromosome amphiploids. Chromosome pairings of amphiploids are reported for the first time. Chromosomes of cultivated sorghums paired exclusively as 10 bivalents, whereas Johnsongrass had a maximum configuration of 5 ring quadrivalents with occasional hexavalents and octovalents. In contrast, 40-chromosome cultivated sorghum had up to 9 ring quadrivalents and 1 hexavalent. Pairing in the 30-chromosome hybrids showed a maximum of 10 trivalents, and that in the 40-chromosome hybrids exhibited 8 quadrivalents, 5 of which were rings, together with a few hexavalents. Amphiploid plants showed up to 3 ring hexavalents, 1 chain hexavalent and a chain of 12 chromosomes. The data suggest that cultivated sorghum is a tetraploid species with the genomic formula AAB1B1, and Johnsongrass is a segmental auto-allo-octoploid, AAAA B1B1B2B2. The model is further substantiated by chromosome pairing in amphiploid plants whose proposed genomic formula is AAAAAA B1B1B1B1 B2B2.

  11. Poor Tc-99m dimercaptosuccinic acid uptake, re-evaluation with Tc-99m MAG3 scintigraphy in Lowe syndrome

    OpenAIRE

    Koca, Gokhan; Atilgan, Hasan Ikbal; Demirel, Koray; Diri, Akif; KORKMAZ, Meliha

    2011-01-01

    Tc-99m dimercaptosuccinic acid (DMSA) is filtered through the glomeruli and reabsorbed by the proximal tubules as low molecular weight proteins. In Lowe syndrome this mechanism is impaired and so poor DMSA uptake is seen. Poor DMSA uptake was shown in very few studies, but none mentioned normal Tc-99m MAG3 uptake. In this case, the patient had poor DMSA uptake, normal MAG3 uptake and a neurogenic bladder in anterior to the left kidney that attenuates left kidney.

  12. Re-Evaluating WASP-12b: Strong Emission at 2.315 micron, Deeper Occultations, and an Isothermal Atmosphere

    CERN Document Server

    Crossfield, Ian J M; Hansen, Brad M S; Tanaka, Ichi; Kodama, Tadayuki

    2012-01-01

    We revisit the atmospheric properties of the extremely hot Jupiter WASP-12b in light of several new developments. First, new narrowband (2.315 micron) secondary eclipse photometry that we present here, which exhibits a planet/star flux ratio of 0.45% +/- 0.06 %, corresponding to a brightness temperature of 3640 K +/- 230 K; second, recent Spitzer/IRAC and Hubble/WFC3 observations; and third, a recently observed star only 1" from WASP-12, which has diluted previous observations and which we further characterize here. We correct past WASP-12b eclipse measurements for the presence of this object, and we revisit the interpretation of WASP-12b's dilution-corrected emission spectrum. The resulting planetary emission spectrum is well-approximated by a blackbody, and consequently our primary conclusion is that the planet's infrared photosphere is nearly isothermal. Thus secondary eclipse spectroscopy is relatively ill-suited to constrain WASP-12b's atmospheric abundances, and transmission spectroscopy may be necessar...

  13. Re-evaluation of the H+/site ratio of mitochondrial electron transport with the oxygen pulse technique.

    Science.gov (United States)

    Brand, M D; Reynafarje, B; Lehninger, A L

    1976-09-25

    The number of protons ejected per pair of electrons passing each energy-conserving site in the electron transport chain (the H+/site ratio) has been investigated in rat liver mitochondria by means of the oxygen pulse technique introduced by Mitchell and Moyle (1967) (Biochem. J. 105, 1147-1162). The usual H+/site values of 2.0 observed by this method were found to be substantially underestimated as a result of the influx of phosphate into the mitochondria. This was shown by three different kinds of experiments. 1. Addition of N-ethylmaleimide or mersalyl, inhibitors of mitochondrial phosphate transport, increased the H+/site ratio from 2.0 to 3.0. The dependence of this effect on the concentration of either inhibitor was identical with that for inhibition of phosphate transport. Added phosphate diminished the H+/site ratio to values below 2.0 in the absence of N-ethylmaleimide. N-Ethylmaleimide protected the elevated H+/site ratio of 3.0 against the deleterious effect of added phosphate, but did not prevent a lowering effect of weak acid anions such as 3-hydroxybutyrate. 2. Prior washing of mitochondria to remove the endogenous phosphate that leaks out during the anaerobic preincubation led to H+/site ratios near 3.0, which were not increased by N-ethylmaleimide. Addition of low concentrations of phosphate to such phosphate-depleted mitochondria decreased the H+/site ratio to 2.0; addition of N-ethylmaleimide returned the ratio to 3.0. 3. Lowering the temperature to 5 degrees, which slows down phosphate transport, led to H+/site values of 3.0 even in the absence of N-ethylmaleimide. The H+/site ratio of 3.0 observed in the absence of phosphate movements was not dependent on any narrowly limited set of experimental conditions. It occurred with either Ca2+ or K+ (in the presence of valinomycin) as mobile permeant cation. It was independent of the concentration of succinate, oxygen, mitochondria, or rotenone, additions of Ca2+, Li+, or Na+ and was independent of medium pH between 6.5 and 7.5. Inhibitors of the transport of ions or acids other than phosphate did not affect the H+/site ratio. These results indicate that re-uptake of endogenous phosphate, lost from mitochondria during anaerobic preincubation, reduces the observed H+ ejection and leads to underestimated H+/site ratios of 2.0 in the oxygen pulse method. When phosphate movements are eliminated by the procedures described above, the observed H+/site ratio is about 3.0. This value appears to be closer to the true H+/site ratio for the primary H+ ejection process during electron transport. PMID:9396

  14. Reply Comments on Phys. Rev. D89, 097101 (2014) "Reevaluation of the parton distribution of strange quarks in the nucleon"

    CERN Document Server

    Aschenauer, E C; Joosten, S; Rith, K; Schnell, G; Van Hulse, C

    2015-01-01

    In the "Comments on Phys. Rev. D89, 097101 (2014)", the Author presents a number of studies to conjecture that the analysis by the HERMES Collaboration presented in Phys. Rev. D89, 097101 (2014) likely suffers from effects that invalidate the leading-order analysis used in that publication. In our opinion, the Author has drawn erroneous conclusions. We present below a discussion of his arguments and the results from a repetition of that analysis using a range of parton distribution sets. The spread in those results precludes credible conclusions and demonstrates the sensitivity of the analysis to poorly known input data (unfavored FFs, strange-quark distributions, and mixed singlet and nonsinglet quantities).

  15. Proposed Risk-Informed Seismic Hazard Periodic Reevaluation Methodology for Complying with DOE Order 420.1C

    Energy Technology Data Exchange (ETDEWEB)

    Kammerer, Annie [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    Department of Energy (DOE) nuclear facilities must comply with DOE Order 420.1C Facility Safety, which requires that all such facilities review their natural phenomena hazards (NPH) assessments no less than every ten years. The Order points the reader to Standard DOE-STD-1020-2012. In addition to providing a discussion of the applicable evaluation criteria, the Standard references other documents, including ANSI/ANS-2.29-2008 and NUREG-2117. These documents provide supporting criteria and approaches for evaluating the need to update an existing probabilistic seismic hazard analysis (PSHA). All of the documents are consistent at a high level regarding the general conceptual criteria that should be considered. However, none of the documents provides step-by-step detailed guidance on the required or recommended approach for evaluating the significance of new information and determining whether or not an existing PSHA should be updated. Further, all of the conceptual approaches and criteria given in these documents deal with changes that may have occurred in the knowledge base that might impact the inputs to the PSHA, the calculated hazard itself, or the technical basis for the hazard inputs. Given that the DOE Order is aimed at achieving and assuring the safety of nuclear facilities—which is a function not only of the level of the seismic hazard but also the capacity of the facility to withstand vibratory ground motions—the inclusion of risk information in the evaluation process would appear to be both prudent and in line with the objectives of the Order. The purpose of this white paper is to describe a risk-informed methodology for evaluating the need for an update of an existing PSHA consistent with the DOE Order. While the development of the proposed methodology was undertaken as a result of assessments for specific SDC-3 facilities at Idaho National Laboratory (INL), and it is expected that the application at INL will provide a demonstration of the methodology, there is potential for general applicability to other facilities across the DOE complex. As such, both a general methodology and a specific approach intended for INL are described in this document. The general methodology proposed in this white paper is referred to as the “seismic hazard periodic review methodology,” or SHPRM. It presents a graded approach for SDC-3, SDC-4 and SDC-5 facilities that can be applied in any risk-informed regulatory environment by once risk-objectives appropriate for the framework are developed. While the methodology was developed for seismic hazard considerations, it can also be directly applied to other types of natural hazards.

  16. Reevaluation of the average prompt neutron emission multiplicity (nubar) values from fission of uranium and transuranium nuclides

    International Nuclear Information System (INIS)

    In response to a need of the safeguards community, we have begun an evaluation effort to upgrade the recommended values of the prompt neutron emission multiplicity distribution, P/sub nu/ and its average value, nubar. This paper will report on progress achieved thus far. The evaluation of the uranium, plutonium, americium and curium nuclide's nubar values will be presented. The recommended values will be given and discussed. 61 references

  17. Quaternary volcanism in the Acambay graben, Mexican Volcanic Belt: Re-evaluation for potential volcanic danger in central Mexico

    Science.gov (United States)

    Aguirre-Diaz, G. J.; Pedrazzi, D.; Lacan, P.; Roldan-Quintana, J.; Ortuňo, M.; Zuniga, R. R.; Laurence, A.

    2015-12-01

    The Mexican Volcanic Belt (MVB) is best known for the major active stratovolcanoes, such as Popocatépetl, Citlaltépetl and Colima. The most common stratovolcanoes in this province are modest-size cones with heights of 800 to 1000 m. Examples are Tequila, Sangangüey, Las Navajas, Culiacán, La Joya, El Zamorano, Temascalcingo and Altamirano; these last two were formed within the Acambay Graben in central MVB. The Acambay graben (20 x 70 km) is 100 km to the NW of Mexico City, with E-W trending seismically active normal faults; in particular the Acambay-Tixmadejé fault related to a mB =7 earthquake in 1912. Within the graben there are many volcanic structures, including calderas, domes, cinder cones and stratovolcanoes; Temascalcingo and Altamirano are the largest, with about 800 and 900 m heights, respectively. Temascalcingo is mostly composed of dacitic lavas and block and ash flow deposits. Includes a 3 x 2.5 km summit caldera and a magmatic sector collapse event with the associated debris avalanche deposit. 14C ages of 37-12 ka correspond to the volcano's latest phases that produced pyroclastic deposits. A major plinian eruption formed the San Mateo Pumice with an age of <20 Ka. Altamirano volcano is poorly studied; it is andesitic-dacitic, composed of lavas, pyroclastic flow deposits, and pumice fallouts. Morphologically is better preserved than Temascalcingo, and it should be younger. 14C ages of 4.0-2.5 ka were performed in charcoal within pyroclastic flow deposits that apparently were erupted from Altamirano. An undated 3 m thick pumice fallout on the flanks of Altamirano volcano could be also Holocene. It represents a major explosive event. The relatively young ages found in volcanic deposits within the Acambay graben raise the volcanic danger level in this area, originally thought as an inactive volcanic zone. The two major volcanoes, Temascalcingo and Altamirano, should be considered as dormant volcanoes that could restart activity at any time. We thanks grant DGAPA-UNAM-PAPIIT IN-104615.

  18. Lymphatic marker podoplanin/D2-40 in human advanced cirrhotic liver- Re-evaluations of microlymphatic abnormalities

    Directory of Open Access Journals (Sweden)

    Yoshimura Kazunori

    2010-11-01

    Full Text Available Abstract Background From the morphological appearance, it was impossible to distinguish terminal portal venules from small lymphatic vessels in the portal tract even using histochemical microscopic techniques. Recently, D2-40 was found to be expressed at a high level in lymphatic endothelial cells (LECs. This study was undertaken to elucidate hepatic lymphatic vessels during progression of cirrhosis by examining the expression of D2-40 in LECs. Methods Surgical wedge biopsy specimens were obtained from non-cirrhotic portions of human livers (normal control and from cirrhotic livers (LC (Child A-LC and Child C-LC. Immunohistochemical (IHC, Western blot, and immunoelectron microscopic studies were conducted using D2-40 as markers for lymphatic vessels, as well as CD34 for capillary blood vessels. Results Imunostaining of D2-40 produced a strong reaction in lymphatic vessels only, especially in Child C-LC. It was possible to distinguish the portal venules from the small lymphatic vessels using D-40. Immunoelectron microscopy revealed strong D2-40 expression along the luminal and abluminal portions of the cell membrane of LECs in Child C-LC tissue. Conclusion It is possible to distinguish portal venules from small lymphatic vessels using D2-40 as marker. D2-40- labeling in lymphatic capillary endothelial cells is related to the degree of fibrosis in cirrhotic liver.

  19. [Re-evaluation of the medical practice and the medicine in the later half of the Chosun dynasty].

    Science.gov (United States)

    Kim, Seong Su

    2009-06-01

    The state-running medical institutions which had been instituted in the earlier period of the Chosun dynasty substantially downsized during the reconstructing process after the major wars with Japan and Qing dynasty. The downsizing was mainly due to the malfunctioning public financial system; but it was also due to the growth of the private medical market. The growth of the private medical market reoriented the focus of the public health system of the Chosun dynasty from providing treatment for every minor disease to providing the more efficient policy against epidemic. Hwal-in Seo (a temporary local public health center established for epidemic) became a new core of the dynasty's health policy under the phrase of "Ae Rye (saving the rituals)." As the changes of the dynasty's public health policy, the growing private medical market had been admitted into the public domain. Chosun government once had declared Sa Yak Gye (a private mutual-aid group for medicine) illegal and prohibited the private groups to be organized. Instead, with the policy change mentioned above, the government tried to support the private mutual-aid group for medicine while forbidding sales of fake medicine, restraining rise of price of medicine. Especially the Do go merchants often caused the sudden rise of price of medicine by bulk purchasing. Medical practice was reassessed as the period when it was considered as one of the lowest professions had been over. Although the Yangban class still refused to be a professional medical practitioner themselves, they also well understood the value of medicine as a field of study to save human and dismissed negative perception on medicine. Medicine as a field of study and medical practice, which had been underestimated under the ruling system influenced by the Song Confucianism and the status system of the Chosun dynasty, faced a new era. The whole society guaranteed more free practices of the medical practitioners and they were recognized for their works. With the change of social environment, the government officials gradually realized needs to discuss how they could educate and recruit medical practitioners to provide advanced medical treatment and what provisions they had to legislate to ensure the stable supply of the medicine. It is certain that the transformation developed in the medical environment and the changes of the public health policy up to 18th century Chosun dynasty accompanied the emergence of the commercial society. However, the overall social urge was still not enough to induce the actual law-making process. The change of the public health policy and the growth of the private medical market were surely the evidence of the transforming Chosun society; at the same time, they also revealed the immaturity of the medical environment which was not able to lead new health policies. PMID:19636190

  20. Seeking Missing Pieces in Science Concept Assessments: Reevaluating the Brief Electricity and Magnetism Assessment through Rasch Analysis

    Science.gov (United States)

    Ding, Lin

    2014-01-01

    Discipline-based science concept assessments are powerful tools to measure learners' disciplinary core ideas. Among many such assessments, the Brief Electricity and Magnetism Assessment (BEMA) has been broadly used to gauge student conceptions of key electricity and magnetism (E&M) topics in college-level introductory physics courses.…

  1. A reevaluation of the vestibulo-ocular reflex: new ideas of its purpose, properties, neural substrate, and disorders

    Science.gov (United States)

    Leigh, R. J.; Brandt, T.

    1993-01-01

    Conventional views of the vestibulo-ocular reflex (VOR) have emphasized testing with caloric stimuli and by passively rotating patients at low frequencies in a chair. The properties of the VOR tested under these conditions differ from the performance of this reflex during the natural function for which it evolved--locomotion. Only the VOR (and not visually mediated eye movements) can cope with the high-frequency angular and linear perturbations of the head that occur during locomotion; this is achieved by generating eye movements at short latency (< 16 msec). Interpretation of vestibular testing is enhanced by the realization that, although the di- and trisynaptic components of the VOR are essential for this short-latency response, the overall accuracy and plasticity of the VOR depend upon a distributed, parallel network of neurons involving the vestibular nuclei. Neurons in this network variously upon a distributed, parallel network of neurons involving the vestibular nuclei. Neurons in this network variously encode inputs from the labyrinthine semicircular canals and otoliths, as well as from the visual and somatosensory systems. The central vestibular pathways branch to contact vestibular cortex (for perception) and the spinal cord (for control of posture). Thus, the vestibular nuclei basically coordinate the stabilization of gaze and posture, and contribute to the perception of verticality and self-motion. Consequently, brainstem disorders that disrupt the VOR cause not just only nystagmus, but also instability of posture (eg, increased fore-aft sway in patients with downbeat nystagmus) and disturbance of spatial orientation (eg, tilt of the subjective visual vertical in Wallenberg's syndrome).

  2. Insight from Frogs: Sonic Hedgehog Gene Expression and a Re-evaluation of the Vertebrate Odontogenic Band.

    Science.gov (United States)

    Grieco, Theresa M; Hlusko, Leslea J

    2016-08-01

    While the identification of conserved processes across multiple taxa leads to an understanding of fundamental developmental mechanisms, the ways in which different animals fail to conform to common developmental processes can elucidate how evolution modifies development to result in the vast array of morphologies seen today-the developmental mechanisms that lead to anatomical variation. Odontogenesis-how teeth are initiated and formed-is well suited to the examination of both developmental conservation and phenotypic diversity. We suggest here that the study of early tooth development, the period of odontogenic band development, reveals departures from conserved mechanisms that question the role of players in the developmental process. In the earliest stages of odontogenesis, Sonic hedgehog (Shh) gene expression is interpreted as critical evidence of tooth initiation prior to any histological indication. However, a detailed examination of studies of tooth development across a wide range of taxa reveals that several vertebrate species fail to conform to the expectations of the Shh Consensus Model, calling for a reconsideration of the assumed causality of epithelial Shh in tooth initiation. We present new Shh gene expression data for an amphibian, the frog Silurana (Xenopus) tropicalis. In these animals, craniofacial and odontogenic developmental processes are more disjunct, and thereby provide a natural test of the hypothesis that Shh is immediately required for subsequent tooth development. Our results suggest that Shh expression may actually be related to the formation of the mouth rather than a required precursor to subsequent tooth formation. Anat Rec, 299:1099-1109, 2016. © 2016 Wiley Periodicals, Inc. PMID:27262165

  3. Re-evaluation of the Micrometeor Mass Flux into the Earth's Atmosphere Using Arecibo UHF Radar Data.

    Science.gov (United States)

    Meisel, D. D.

    2005-12-01

    Thanks to the advanced search and analysis algorithms developed and written by S. J. Briczinski and J. D. Mathews, CSSL-Penn State, a highly homogeneous sample of nearly 20,000 events in 2001 and 2004 has been obtained and subjected to an extensive statistical analysis. Significant correlations of several dynamical parameters of decelerating particles with height have been found leading to the recovery of particle density. Previously radii were derived assuming the density was the canonical 3000 kg/m3. The density histogram can be deconvolved to compensate for inclination with the beam and possible variations of shape through a variable drag coefficient. Now that individual particle densities are available, revised radii and mass histograms have been derived. The new results and their implications for the dust component of the Earth's upper atmosphere will be discussed in detail. This effort has been supported by NSF Grant AST 02-05848 to The Pennsylvania State University and AST 02-05974 to SUNY-Geneseo The Arecibo Observatory is part of the National Astronomy and Ionosphere Center, which is operated by Cornell University under cooperative agreement with the National Science Foundation.

  4. Reevaluating Key Evidence for the Development of Rehearsal: Phonological Similarity Effects in Children Are Subject to Proportional Scaling Artifacts

    Science.gov (United States)

    Jarrold, Christopher; Citroen, Rebecca

    2013-01-01

    The size of an individual's phonological similarity effect for visually presented material is assumed to reflect his or her ability to recode, and by implication rehearse, information in verbal short-term memory. Many studies have shown that under these conditions, the size of this effect interacts with age, tending to be nonsignificant in…

  5. Re-evaluation of the PBAN receptor (PBANR molecule: characterization of PBANR variants expressed in the pheromone glands of moths

    Directory of Open Access Journals (Sweden)

    Jae Min Lee

    2012-01-01

    Full Text Available Sex pheromone production in most moths is initiated following pheromone biosynthesis activating neuropeptide receptor (PBANR activation. PBANR was initially cloned from pheromone glands (PGs of Helicoverpa zea and Bombyx mori. The B. mori PBANR is characterized by a relatively long C-terminus that is essential for ligand-induced internalization, whereas the H. zea PBANR has a shorter C-terminus that lacks features present in the B. mori PBANR critical for internalization. Multiple PBANRs have been reported to be concurrently expressed in the larval CNS of Heliothis virescens. In the current study, we sought to examine the prevalence of multiple PBANRs in the PGs of three moths and to ascertain their potential functional relevance. Multiple PBANR variants (As, A, B, and C were cloned from the PGs of all species examined with PBANR-C the most highly expressed. Alternative splicing of the C-terminal coding sequence of the PBAN gene gives rise to the variants, which are distinguishable only by the length and composition of their respective C-terminal tails. Transient expression of fluorescent PBANR chimeras in insect cells revealed that PBANR-B and PBANR-C localized exclusively to the cell surface while PBANR-As and PBANR-A exhibited varying degrees of cytosolic localization. Similarly, only the PBANR-B and PBANR-C variants underwent ligand-induced internalization. Taken together, our results suggest that PBANR-C is the principal receptor molecule involved in PBAN signaling regardless of moth species. The high GC content of the C-terminal coding sequence in the B and C variants, which makes amplification using conventional polymerases difficult, likely accounts for previous preferential amplification of PBANR-A like receptors from other species.

  6. The Cost Escalation of Rail Projects: Using Previous Experience to Re-Evaluate the CalSpeed Estimates

    OpenAIRE

    Leavitt, Dan; Ennis, Sean; McGovern, Pat

    1993-01-01

    This report is a follow-up study to last year's CalSpeed publication, "High-Speed Trains for California," Working Paper No. 565. The purpose of this paper is to test rigorously and critically the cost estimate methodology presented in that previous working paper. This has been accomplished primarily by focusing on the issue of cost escalation of rail projects, with reference to both U.S. and foreign experience.

  7. A re-evaluation of the size of the white shark (Carcharodon carcharias) population off California, USA.

    Science.gov (United States)

    Burgess, George H; Bruce, Barry D; Cailliet, Gregor M; Goldman, Kenneth J; Grubbs, R Dean; Lowe, Christopher G; MacNeil, M Aaron; Mollet, Henry F; Weng, Kevin C; O'Sullivan, John B

    2014-01-01

    White sharks are highly migratory and segregate by sex, age and size. Unlike marine mammals, they neither surface to breathe nor frequent haul-out sites, hindering generation of abundance data required to estimate population size. A recent tag-recapture study used photographic identifications of white sharks at two aggregation sites to estimate abundance in "central California" at 219 mature and sub-adult individuals. They concluded this represented approximately one-half of the total abundance of mature and sub-adult sharks in the entire eastern North Pacific Ocean (ENP). This low estimate generated great concern within the conservation community, prompting petitions for governmental endangered species designations. We critically examine that study and find violations of model assumptions that, when considered in total, lead to population underestimates. We also use a Bayesian mixture model to demonstrate that the inclusion of transient sharks, characteristic of white shark aggregation sites, would substantially increase abundance estimates for the adults and sub-adults in the surveyed sub-population. Using a dataset obtained from the same sampling locations and widely accepted demographic methodology, our analysis indicates a minimum all-life stages population size of >2000 individuals in the California subpopulation is required to account for the number and size range of individual sharks observed at the two sampled sites. Even accounting for methodological and conceptual biases, an extrapolation of these data to estimate the white shark population size throughout the ENP is inappropriate. The true ENP white shark population size is likely several-fold greater as both our study and the original published estimate exclude non-aggregating sharks and those that independently aggregate at other important ENP sites. Accurately estimating the central California and ENP white shark population size requires methodologies that account for biases introduced by sampling a limited number of sites and that account for all life history stages across the species' range of habitats.

  8. Re-evaluate the effect of hyperbaric oxygen therapy in cancer - a preclinical therapeutic small animal model study.

    Directory of Open Access Journals (Sweden)

    Sneha Pande

    Full Text Available Tumor hypoxia is a known driver of angiogenesis that also facilitates tumor growth. Moreover, poorly oxygenated central tumor area remains relatively radio or chemo resistant. HBO therapy is known to elevate the levels of dissolved oxygen and eliminates tumor hypoxia. It has been one of the modalities in cancer treatment; therefore its optimization is important. In this experimental study, no cancer enhancing effect was seen during the course of HBO therapy; however, post therapy there was an accelerated growth and progression of tumor. HBO treated mice lived shorter and the response to therapy was dose & tumor volume dependent. HBO therapy probably exert its effect on the cancer proliferating cells through multiple pathways such as increased DNA damage, apoptosis & geno-toxicity leading to slow cancer progression while post therapy tumorigenic effect could be due to impaired DNA repair mechanism, mutagenic effect & aneuploidy as well as altered blood supply & nutrients. Tumor growth reached plateau with time and this finding validated theoretical model predicting tumor reaching an asymptotic limit. While, marked asymmetry observed in tumor volume progression or cancer cell proliferation rate in each of the experimental C3H mouse suggested a need for an alternate small animal pre-clinical cancer therapeutic model.

  9. Trends and variability of midlatitude stratospheric water vapour deduced from the re-evaluated Boulder balloon series and HALOE

    Directory of Open Access Journals (Sweden)

    M. Scherer

    2007-10-01

    Full Text Available This paper presents an updated trend analysis of water vapour in the lower midlatitude stratosphere from the Boulder balloon-borne NOAA frostpoint hygrometer measurements and from the Halogen Occulation Experiment (HALOE. Two corrections for instrumental bias are applied to homogenise the frostpoint data series, and a quality assessment of all soundings after 1991 is presented. Linear trend estimates based on the corrected data for the period 1980–2000 are up to 40% lower than previously reported. Vertically resolved trends and variability are calculated with a multi regression analysis including the quasi-biennal oscillation and equivalent latitude as explanatory variables. In the range of 380 to 640 K potential temperature (≈14 to 25 km, the frostpoint data from 1981 to 2006 show positive linear trends between 0.3± 0.3 and 0.7±0.1%/yr. The same dataset shows trends between −0.2±0.3 and 1.0±0.3%/yr for the period 1992 to 2005. HALOE data over the same time period suggest negative trends ranging from −1.1±0.2 to −0.1±0.1%/yr. In the lower stratosphere, a rapid drop of water vapour is observed in 2000/2001 with little change since. At higher altitudes, the transition is more gradual, with slowly decreasing concentrations between 2001 and 2007. This pattern is consistent with a change induced by a drop of water concentrations at entry into the stratosphere. Previously noted differences in trends and variability between frostpoint and HALOE remain for the homogenised data. Due to uncertainties in reanalysis temperatures and stratospheric transport combined with uncertainties in observations, no quantitative inference about changes of water entering the stratosphere in the tropics could be made with the mid latitude measurements analysed here.

  10. Theoretical reevaluations of black hole mass -- bulge mass relation - I. Influences of the seed black hole mass

    CERN Document Server

    Shirakata, Hikari; Okamoto, Takashi; Makiya, Ryu; Ishiyama, Tomoaki; Matsuoka, Yoshiki; Nagashima, Masahiro; Enoki, Motohiro; Oogi, Taira; Kobayashi, Masakazu A R

    2016-01-01

    We show influences of the mass of seed black holes on black hole mass -- bulge mass relation at z ~ 0 by using a semi-analytic model of galaxy formation combined with large cosmological N-body simulations. We constrain our model to reproduce observed properties of galaxies at z ~ 0. Similar to other semi-analytic models, we place a seed black hole immediately after a galaxy forms. When we set the seed black hole mass to 10^5 M_sun, we find that the model result becomes inconsistent with recent observational results of black hole mass -- bulge mass relation for dwarf galaxies. Namely, the model predicts that bulges with ~ 10^9 M_sun harbor black holes more massive than observed. On the other hand, when we employ seed black holes with 10^3 M_sun or randomly choose their masses in the range of 10^{3-5} M_sun, the black hole mass -- bulge mass relation obtained from these models are consistent with observational results including dispersions. We find that to obtain more stringent restrictions of the mass of seed ...

  11. Comments on Phys. Rev. D89 (2014) 097101 "Reevaluation of the parton distribution of strange quarks in the nucleon"

    CERN Document Server

    Stolarski, M

    2014-01-01

    The HERMES collaboration in Phys. Rev. D89 (2014) 097101 extracted information about the strange quark density in the nucleon. One of the main results is an observation that the shape of the extracted density is very different from the shapes of the strange quark density from global QCD fits and also from that of the light antiquarks. In this paper systematic studies on the HERMES published multiplicity of pion and kaon data are presented. It is shown that the conclusions concerning the strange quark distribution in the nucleon reached in Phys. Rev. D89 (2014) 097101 are at the moment premature.

  12. A new species of the basal "kangaroo" Balbaroo and a re-evaluation of stem macropodiform interrelationships.

    Directory of Open Access Journals (Sweden)

    Karen H Black

    Full Text Available Exceptionally well-preserved skulls and postcranial elements of a new species of the plesiomorphic stem macropodiform Balbaroo have been recovered from middle Miocene freshwater limestone deposits in the Riversleigh World Heritage Area of northwestern Queensland, Australia. This constitutes the richest intraspecific sample for any currently known basal "kangaroo", and, along with additional material referred to Balbaroo fangaroo, provides new insights into structural variability within the most prolific archaic macropodiform clade--Balbaridae. Qualitative and metric evaluations of taxonomic boundaries demonstrate that the previously distinct species Nambaroo bullockensis is a junior synonym of B. camfieldensis. Furthermore, coupled Maximum Parsimony and Bayesian phylogenetic analyses reveal that our new Balbaroo remains represent the most derived member of the Balbaroo lineage, and are closely related to the middle Miocene B. camfieldensis, which like most named balbarid species is identifiable only from isolated jaws. The postcranial elements of Balbaroo concur with earlier finds of the stratigraphically oldest balbarid skeleton, Nambaroo gillespieae, and suggest that quadrupedal progression was a primary gait mode as opposed to bipedal saltation. All Balbaroo spp. have low-crowned bilophodont molars, which are typical for browsing herbivores inhabiting the densely forested environments envisaged for middle Miocene northeastern Australia.

  13. Nurture Net of Nature: Re-Evaluating the Role of Shared Environments in Academic Achievement and Verbal Intelligence

    OpenAIRE

    Daw, Jonathan; Guo, Guang; Harris, Kathie Mullan

    2015-01-01

    Prominent authors in the behavioral genetics tradition have long argued that shared environments do not meaningfully shape intelligence and academic achievement. However, we argue that these conclusions are erroneous due to large violations of the additivity assumption underlying behavioral genetics methods – that sources of genetic and shared and nonshared environmental variance are independent and non-interactive. This is compounded in some cases by the theoretical equation of the effective...

  14. Nurture net of nature: Re-evaluating the role of shared environments in academic achievement and verbal intelligence.

    Science.gov (United States)

    Daw, Jonathan; Guo, Guang; Harris, Kathie Mullan

    2015-07-01

    Prominent authors in the behavioral genetics tradition have long argued that shared environments do not meaningfully shape intelligence and academic achievement. However, we argue that these conclusions are erroneous due to large violations of the additivity assumption underlying behavioral genetics methods - that sources of genetic and shared and nonshared environmental variance are independent and non-interactive. This is compounded in some cases by the theoretical equation of the effective and objective environments, where the former is defined by whether siblings are made more or less similar, and the latter by whether siblings are equally subject to the environmental characteristic in question. Using monozygotic twin fixed effects models, which compare outcomes among genetically identical pairs, we show that many characteristics of objectively shared environments significantly moderate the effects of nonshared environments on adolescent academic achievement and verbal intelligence, violating the additivity assumption of behavioral genetic methods. Importantly, these effects would be categorized as nonshared environmental influences in standard twin models despite their roots in shared environments. These findings should encourage caution among those who claim that the frequently trivial variance attributed to shared environments in behavioral genetic models means that families, schools, and neighborhoods do not meaningfully influence these outcomes. PMID:26004471

  15. Trends and variability of midlatitude stratospheric water vapour deduced from the re-evaluated Boulder balloon series and HALOE

    Directory of Open Access Journals (Sweden)

    M. Scherer

    2008-03-01

    Full Text Available This paper presents an updated trend analysis of water vapour in the lower midlatitude stratosphere from the Boulder balloon-borne NOAA frostpoint hygrometer measurements and from the Halogen Occulation Experiment (HALOE. Two corrections for instrumental bias are applied to homogenise the frostpoint data series, and a quality assessment of all soundings after 1991 is presented. Linear trend estimates based on the corrected data for the period 1980–2000 are up to 40% lower than previously reported. Vertically resolved trends and variability are calculated with a multi regression analysis including the quasi-biennal oscillation and equivalent latitude as explanatory variables. In the range of 380 to 640 K potential temperature (≈14 to 25 km, the frostpoint data from 1981 to 2006 show positive linear trends between 0.3±0.3 and 0.7±0.1%/yr. The same dataset shows trends between −0.2±0.3 and 1.0±0.3%/yr for the period 1992 to 2005. HALOE data over the same time period suggest negative trends ranging from −1.1±0.2 to −0.1±0.1%/yr. In the lower stratosphere, a rapid drop of water vapour is observed in 2000/2001 with little change since. At higher altitudes, the transition is more gradual, with slowly decreasing concentrations between 2001 and 2007. This pattern is consistent with a change induced by a drop of water concentrations at entry into the stratosphere. Previously noted differences in trends and variability between frostpoint and HALOE remain for the homogenised data. Due to uncertainties in reanalysis temperatures and stratospheric transport combined with uncertainties in observations, no quantitative inference about changes of water entering the stratosphere in the tropics could be made with the mid latitude measurements analysed here.

  16. Re-evaluating Science and Technology trough the lens of Arts and Graphic Design. A case study in La Spezia.

    Science.gov (United States)

    Locritani, Marina; Stroobant, Mascha; Talamoni, Roberta; Merlino, Silvia; Guccinelli, Giacomo; Benvenuti, Lucrezia; Zatta, Consuelo; Stricker, Federica; Zappa, Franco; Sgherri, Matteo

    2016-04-01

    The Human society is getting more and more involved with scientific and environmental issues both in terms of consciousness of good practices or participation in legislative decision-making processes. A common effort to preserve our planet is asked every day, for example through recycling practices, reduction of pollutant emission, use of alternative energies and awareness of risks natural and human-induced hazards. In addition, public opinion is often involved for issues of scientific interest (e.g. genetically modified organisms GMO). Unfortunately, the Eurobarometer (Eurobarometer Special 419 Report, Public perceptions of Science, Research and Innovation, 2014) indicates, especially for the Italian population, a low interest in science and therefore a lack of confidence in the potential of the research. It is hence important for people to be informed of the progress made by science and the importance of the researchers' role. Education, awareness and dissemination of scientific results and issues must be made through simple and appealing channels that must reach all levels of society and age groups: from children to older people. A common and comprehensible language for everyone can be found in Graphic Arts. For this reasons, the working group for science dissemination of La Spezia has increased, in recent years, close relationship with some artists (especially graphic designers). The collaboration between two different worlds (art and science) has allowed us to see an unusual approach and to translate concepts developed in images which everyone can understand also under an emotional point of view. Different techniques and tools based on the target to be reached have been employed. 1. Conferences. Gender differences issues in science professions and more generally in society has been addressed through interactive conferences and round tables during the European Researchers' Night 2015 and other occasions for general public. Arguments and questions were described and imprinted in the minds of the public thanks to the support of speed painting and visual scribing, which made it more understandable, interesting and direct. 2. Edutainment activities. Two games have been build up for children aged between 7 and 13 years as a part of the European Researchers' Night activities (2011 and 2014-2015): a great board game with questions and drawings related to marine ecology and environmental protection and a memory game through which children can learn notions on Earthquakes, Volcanoes and Environment. Children's learning is facilitated if bound by game, and in this case images are more direct than words. 3. Surveys. A graphic questionnaire has been created in order to understand science perception and/or stereotypes in children who do not yet know how to read and write. In all these cases the relationship between researchers and artists has been extremely constructive and fruitful: researchers had to simplify their object of study in order to be able to disclose concepts that have been then translated into a simple and easy language.

  17. Proposed Risk-Informed Seismic Hazard Periodic Reevaluation Methodology for Complying with DOE Order 420.1C

    Energy Technology Data Exchange (ETDEWEB)

    Kammerer, Annie [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-10-01

    Department of Energy (DOE) nuclear facilities must comply with DOE Order 420.1C Facility Safety, which requires that all such facilities review their natural phenomena hazards (NPH) assessments no less frequently than every ten years. The Order points the reader to Standard DOE-STD-1020-2012. In addition to providing a discussion of the applicable evaluation criteria, the Standard references other documents, including ANSI/ANS-2.29-2008 and NUREG-2117. These documents provide supporting criteria and approaches for evaluating the need to update an existing probabilistic seismic hazard analysis (PSHA). All of the documents are consistent at a high level regarding the general conceptual criteria that should be considered. However, none of the documents provides step-by-step detailed guidance on the required or recommended approach for evaluating the significance of new information and determining whether or not an existing PSHA should be updated. Further, all of the conceptual approaches and criteria given in these documents deal with changes that may have occurred in the knowledge base that might impact the inputs to the PSHA, the calculated hazard itself, or the technical basis for the hazard inputs. Given that the DOE Order is aimed at achieving and assuring the safety of nuclear facilities—which is a function not only of the level of the seismic hazard but also the capacity of the facility to withstand vibratory ground motions—the inclusion of risk information in the evaluation process would appear to be both prudent and in line with the objectives of the Order. The purpose of this white paper is to describe a risk-informed methodology for evaluating the need for an update of an existing PSHA consistent with the DOE Order. While the development of the proposed methodology was undertaken as a result of assessments for specific SDC-3 facilities at Idaho National Laboratory (INL), and it is expected that the application at INL will provide a demonstration of the methodology, there is potential for general applicability to other facilities across the DOE complex. As such, both a general methodology and a specific approach intended for INL are described in this document. The general methodology proposed in this white paper is referred to as the “seismic hazard periodic review methodology,” or SHPRM. It presents a graded approach for SDC-3, SDC-4 and SDC-5 facilities that can be applied in any risk-informed regulatory environment by once risk-objectives appropriate for the framework are developed. While the methodology was developed for seismic hazard considerations, it can also be directly applied to other types of natural hazards.

  18. A reevaluation of the anatomy of the jaw-closing system in the extant coelacanth Latimeria chalumnae

    Science.gov (United States)

    Dutel, Hugo; Herrel, Anthony; Clément, Gaël; Herbin, Marc

    2013-11-01

    The coelacanth Latimeria is the only extant representative of the Actinistia, a group of sarcopterygian fishes that originated in the Devonian. Moreover, it is the only extant vertebrate in which the neurocranium is divided into an anterior and a posterior portion that articulate by means of an intracranial joint. This joint is thought to be highly mobile, allowing an elevation of the anterior portion of the skull during prey capture. Here we provide a new description of the skull and jaw-closing system in Latimeria chalumnae in order to better understand its skull mechanics during prey capture. Based on a dissection and the CT scanning of an adult coelacanth, we provide a detailed description of the musculature and ligaments of the jaw system. We show that the m. adductor mandibulae is more complex than previously reported. We demonstrate that the basicranial muscle inserts more anteriorly than has been described previously, which has implications for its function. Moreover, the anterior insertion of the basicranial muscle does not correspond to the posterior tip of the tooth plate covering the parasphenoid, questioning previous inferences made on fossil coelacanths and other sarcopterygian fishes. Strong ligaments connect the anterior and the posterior portions of the skull at the level of the intracranial joint, as well as the notochord and the catazygals. These observations suggest that the intracranial joint is likely to be less mobile than previously thought and that its role during feeding merits to be reexamined.

  19. [A transference from somewhere else: reevaluation of the controversies between Melanie Klein and Anna Freud (of noise and silence)].

    Science.gov (United States)

    Prado de Oliveira, L E

    1995-01-01

    Starting from The Freud-Klein Controversies, the author explores the historical reality of these controversies and their transformations into myth which give them the appearance of titanic fights. The verification of the different periods, the description of the variations in themes and style of intervention of the principal actors of these debates show aspects of the way a psychoanalytic institute works and of the theoretical elaboration in psychoanalysis: these appear very different from what the myth suggests. The major function of myth is, as Freud noted and Strachey reminds us, to hide very trite, even shameful realities. History and myth, theoritical effort and institutional life are all organized from and around transference, a major axis of psychoanalytic thought. When we organize our psychoanalytic lives in societies, we have the pride or the vanity of participating in a great historical movement. This goes back to the work of transference in institutional life that involves primal objects in the crudeness of their sexuality. Such is the constraining strength of transference. Being fully conscious of it, like Stratchey or Balint show us, enables to alleviate its violence and stimulate creativity.

  20. Artiodactyls from the Pondaung Formation (Myanmar): new data and reevaluation of the South Asian Faunal Province during the Middle Eocene

    Science.gov (United States)

    Métais, Grégoire; Soe, Aung Naing; Marivaux, Laurent; Beard, K. Christopher

    2007-09-01

    Although Asia is thought to have played a critical role in the radiation of artiodactyls, the fossil record of stem selenodonts (“dichobunoids”) remains dramatically poor in tropical Asian regions. In this study, we report a new dichobunid genus and species Cadutherium kyaukmagyii and a new basal ruminant genus and species Irrawadymeryx pondaungi, from the late Middle Eocene Pondaung Formation, Central Myanmar. Although the scarcity of the present material prevents any attempts to investigate the phylogenetic relationships of Cadutherium with contemporaneous forms from other Holarctic landmasses, this new form shed new light on the diversity of these small rabbit-like ungulates during a key period of their evolutionary history. Reexamination of the small-bodied artiodactyls from Pondaung leads us to propose new identifications of certain published specimens and, in turn, to investigate the temporal and geographic distribution of taxa recognized in the Pondaung Formation. Although fragmentary, these potential new taxa reveal an unsuspected diversity of small forms among artiodactyls of Pondaung. This addition to the Eocene record of dichobunoids and early ruminants provides further insight in the diversity of dental patterns among small artiodactyls from the Pondaung Formation and attests to the antiquity of these groups in Southeast Asia.

  1. Re-evaluation of Yellowstone grizzly bear population dynamics not supported by empirical data: response to Doak & Cutler

    Science.gov (United States)

    van Manen, Frank T.; Ebinger, Michael R.; Haroldson, Mark A.; Harris, Richard B.; Higgs, Megan D.; Cherry, Steve; White, Gary C.; Schwartz, Charles C.

    2014-01-01

    Doak and Cutler critiqued methods used by the Interagency Grizzly Bear Study Team (IGBST) to estimate grizzly bear population size and trend in the Greater Yellowstone Ecosystem. Here, we focus on the premise, implementation, and interpretation of simulations they used to support their arguments. They argued that population increases documented by IGBST based on females with cubs-of-the-year were an artifact of increased search effort. However, we demonstrate their simulations were neither reflective of the true observation process nor did their results provide statistical support for their conclusion. They further argued that survival and reproductive senescence should be incorporated into population projections, but we demonstrate their choice of extreme mortality risk beyond age 20 and incompatible baseline fecundity led to erroneous conclusions. The conclusions of Doak and Cutler are unsubstantiated when placed within the context of a thorough understanding of the data, study system, and previous research findings and publications.

  2. A new species of the basal "kangaroo" Balbaroo and a re-evaluation of stem macropodiform interrelationships.

    Science.gov (United States)

    Black, Karen H; Travouillon, Kenny J; Den Boer, Wendy; Kear, Benjamin P; Cooke, Bernard N; Archer, Michael

    2014-01-01

    Exceptionally well-preserved skulls and postcranial elements of a new species of the plesiomorphic stem macropodiform Balbaroo have been recovered from middle Miocene freshwater limestone deposits in the Riversleigh World Heritage Area of northwestern Queensland, Australia. This constitutes the richest intraspecific sample for any currently known basal "kangaroo", and, along with additional material referred to Balbaroo fangaroo, provides new insights into structural variability within the most prolific archaic macropodiform clade--Balbaridae. Qualitative and metric evaluations of taxonomic boundaries demonstrate that the previously distinct species Nambaroo bullockensis is a junior synonym of B. camfieldensis. Furthermore, coupled Maximum Parsimony and Bayesian phylogenetic analyses reveal that our new Balbaroo remains represent the most derived member of the Balbaroo lineage, and are closely related to the middle Miocene B. camfieldensis, which like most named balbarid species is identifiable only from isolated jaws. The postcranial elements of Balbaroo concur with earlier finds of the stratigraphically oldest balbarid skeleton, Nambaroo gillespieae, and suggest that quadrupedal progression was a primary gait mode as opposed to bipedal saltation. All Balbaroo spp. have low-crowned bilophodont molars, which are typical for browsing herbivores inhabiting the densely forested environments envisaged for middle Miocene northeastern Australia. PMID:25409233

  3. Steady-state brain glucose transport kinetics re-evaluated with a four-state conformational model

    Directory of Open Access Journals (Sweden)

    João M N Duarte

    2009-10-01

    Full Text Available Glucose supply from blood to brain occurs through facilitative transporter proteins. A near linear relation between brain and plasma glucose has been experimentally determined and described by a reversible model of enzyme kinetics. A conformational four-state exchange model accounting for trans-acceleration and asymmetry of the carrier was included in a recently developed multi-compartmental model of glucose transport. Based on this model, we demonstrate that brain glucose (Gbrain as function of plasma glucose (Gplasma can be described by a single analytical equation namely comprising three kinetic compartments: blood, endothelial cells and brain. Transport was described by four parameters: apparent half saturation constant Kt, apparent maximum rate constant Tmax, glucose consumption rate CMRglc, and the iso-inhibition constant Kii that suggests Gbrain as inhibitor of the isomerisation of the unloaded carrier. Previous published data, where Gbrain was quantified as a function of plasma glucose by either biochemical methods or NMR spectroscopy, were used to determine the aforementioned kinetic parameters. Glucose transport was characterized by Kt ranging from 1.5 to 3.5 mM, Tmax/CMRglc from 4.6 to 5.6, and Kii from 51 to 149 mM. It was noteworthy that Kt was on the order of a few mM, as previously determined from the reversible model. The conformational four-state exchange model of glucose transport into the brain includes both efflux and transport inhibition by Gbrain, predicting that Gbrain eventually approaches a maximum concentration. However, since Kii largely exceeds Gplasma, iso-inhibition is unlikely to be of substantial importance for plasma glucose below 25 mM. As a consequence, the reversible model can account for most experimental observations under euglycaemia and moderate cases of hypo- and hyperglycaemia.

  4. Theoretical re-evaluations of the black hole mass-bulge mass relation - I. Effect of seed black hole mass

    Science.gov (United States)

    Shirakata, Hikari; Kawaguchi, Toshihiro; Okamoto, Takashi; Makiya, Ryu; Ishiyama, Tomoaki; Matsuoka, Yoshiki; Nagashima, Masahiro; Enoki, Motohiro; Oogi, Taira; Kobayashi, Masakazu A. R.

    2016-10-01

    We explore the effect of varying the mass of a seed black hole on the resulting black hole mass-bulge mass relation at z ˜ 0, using a semi-analytic model of galaxy formation combined with large cosmological N-body simulations. We constrain our model by requiring that the observed properties of galaxies at z ˜ 0 are reproduced. In keeping with previous semi-analytic models, we place a seed black hole immediately after a galaxy forms. When the mass of the seed is set at 105 M⊙, we find that the model results become inconsistent with recent observational results of the black hole mass-bulge mass relation for dwarf galaxies. In particular, the model predicts that bulges with ˜109 M⊙ harbour larger black holes than observed. On the other hand, when we employ seed black holes of 103 M⊙ or select their mass randomly within a 103-5 M⊙ range, the resulting relation is consistent with observation estimates, including the observed dispersion. We find that, to obtain stronger constraints on the mass of seed black holes, observations of less massive bulges at z ˜ 0 are a more powerful comparison than the relations at higher redshifts.

  5. (2012 30 Windsor Y B Access Just 225 RE-EVALUATING INDEPENDENCE: THE EMERGING PROBLEM OF CROWN-POLICE ALIGNMENT

    Directory of Open Access Journals (Sweden)

    Jeremy Tatum

    2015-05-01

    La partie II fera ressortir les rôles distincts de la police et des procureurs de la poursuite et fournira quelques renseignements généraux sur la question de l’alignement des fonctions de la Couronne et de la police. La partie III examinera un nombre d’affaires récentes où des bureaux et des procureurs qui exercaient leurs fonctions de poursuivants, semblent avoir agi dans l’intérêt de la police plutôt que dans l’intérêt public. Finalement, parce que le problème de l’alignement des fonctions de la Couronne et la de police est, par nature, provincial et localisé, l’auteur tentera de démontrer, dans la partie IV, le rôle crucial que les barreaux et d’autres administrations publiques jouent lorsqu’il s’agit de surveiller le déroulement des poursuites et de veiller à ce que les procureurs généraux voient effectivement à ce que les affaires publiques soient administrées en conformité avec le droit.

  6. Using stable isotopes of water to re-evaluate the recharge/discharge functions of North American bogs and fens

    Science.gov (United States)

    Levy, Zeno; Siegel, Donald; Glaser, Paul; Dasgupta, Soumitri

    2014-05-01

    In North American mires hydrologists commonly find raised bog crests and low-lying fen water tracks to be focal points for groundwater recharge and discharge, respectively. To further test these observations we synoptically surveyed vertical profiles of peat pore water δ18O/δ2H and major mineral solutes from a range of bog and fen landforms across the Glacial Lake Agassiz Peatlands (GLAP) of northern Minnesota. We also sampled a detailed transect through a 150 km2 bog-fen complex in the Red Lake II peatland watershed of the GLAP. The molar ratios of Ca/Mg in the pore water beneath the Red Lake II bog crest are depleted in Mg with respect to the atmospheric average of 3.6, indicative of preferential flushing of Mg from the peat by meteoric recharge. Higher solute concentrations in the middle of the peat profile at an adjacent fen show focused groundwater discharge with Ca/Mg ratios of ~1.4, similar to that of water from local wells tapping underlying glacial till. However, contrary to expectations, we find evidence that modern recharge has penetrated throughout the peat column beneath both bog and fen landforms throughout the GLAP. Landform surface features control the isotopic recharge value. These landform-specific isotope signatures propagate through vertical pore water profiles. Pore waters deeper than 0.5 m partition into discrete ranges of δ18O according to three a priori landform classifications: 1) -11.9 ± 0.4 o for bog crests, 2) -10.6 ± 0.1 o for Sphagnum lawns, and 3) -8.8 ± 1.0 o for fen water tracks. The fen water tracks have standing water at their surface that is seasonally enriched by isotope fractionating evaporation and therefore fingerprints recharge to depths ≥3 m. Incongruities between isotope and solute mixing trends may be related to the dual porosity nature of peat and matrix diffusion, which could supply solutes to active pore spaces following flushing by meteoric recharge. This buffering of base solutes in the deep peat may influence methanogenic bacteria that are sensitive to pH. Our results support the hypothesis that the downward transport of labile carbon substrates from the surface of northern peat basins fuels methane production in deeper peat strata.

  7. Reevaluation of the global warming impacts of algae-derived biofuels to account for possible contributions of nitrous oxide.

    Science.gov (United States)

    Bauer, Sarah K; Grotz, Lara S; Connelly, Elizabeth B; Colosi, Lisa M

    2016-10-01

    The environmental impacts of algae biofuels have been evaluated by life-cycle assessment (LCA); however, these analyses have overlooked nitrous oxide (N2O), a potent greenhouse gas. A literature analysis was performed to estimate algal N2O emissions and assess the impacts of growth conditions on flux magnitudes. Nitrogen source and dissolved oxygen concentration were identified as possible key contributors; therefore, their individual and combined impacts were evaluated using bench-scale experiments. It was observed that maximum N2O emissions (77.5μg/galgae/day) occur under anoxic conditions with nitrite. Conversely, minimum emissions (6.25μg/galgae/day) occur under oxic conditions with nitrate. Aggregated N2O flux estimates were then incorporated into a LCA framework for algae biodiesel. Accounting for "low" N2O emissions mediated no significant increase (<1%) compared to existing GWP estimates; however, "high" N2O emissions mediate an increase of roughly 25%, potentially jeopardizing the anticipated economic and environmental performances of algae biofuels. PMID:27367816

  8. Cross-species conservation of endocrine pathways provides a basis for reevaluation of EDSP tiered testing paradigm

    Science.gov (United States)

    Many structural and functional aspects of the vertebrate hypothalamic-pituitary-gonadal (HPG) axis are known to be highly conserved, but the relative significance of this from a regulatory toxicology perspective has received comparatively little attention. High-quality data gene...

  9. Reevaluation of cortical developmental patterns in Euplotes (s. l.), including a morphogenetic redescription of E. charon (Protozoa, Ciliophora, Euplotida)

    Science.gov (United States)

    Shao, Chen; Ma, Honggang; Gao, Shan; Khaled, Al-Rasheid A.; Song, Weibo

    2010-05-01

    We documented the pattern of cell development in Euplotes charon. The ontogenesis of this species was similar to many of its congeners, except for the formation of the caudal cirri. In E. Charon, a caudal cirrus is formed posterior to each of the rightmost two or three dorsal kinety anlage in the proter, and the second rightmost dorsal kinety in the opisthe. In addition, two caudal cirri are formed posterior to the rightmost dorsal kinety in the opisthe. This pattern of development represents a completely new type. Based on our evaluation, and in comparison with previous studies, we also conclude that the pattern of cell development is variable among species in the Euplotes genera. The variation is particularly evident during the formation of frontoventral and caudal cirri. Based on the segmentation pattern of frontal-midventral transverse cirral anlagen, cirri reduction, and migration of frontoventral cirri, we identified five types: the affinis-type, the eurystomus-type, the charon-type, the raikovi-type and orientalis-type. Euplotes (s. l.) can also be divided into three types based on the formation of caudal cirri: focardii-type, vannus-type and charon-type. Indeed, we conclude that the number (one or two) of marginal cirri should be given as much consideration as the genetic separation. Given this, we reassessed the validity of using genetic separation to classify the group. Generally, the morphogenetic data disagreed with the molecular data (SSrRNA gene sequences). Given these discrepancies, it is too early to draw conclusions on the systematic arrangement of this species-rich taxon.

  10. Re-evaluation of forest biomass carbon stocks and lessons from the world's most carbon-dense forests

    OpenAIRE

    Keith, Heather; Mackey, Brendan G.; Lindenmayer, David B

    2009-01-01

    From analysis of published global site biomass data (n = 136) from primary forests, we discovered (i) the world's highest known total biomass carbon density (living plus dead) of 1,867 tonnes carbon per ha (average value from 13 sites) occurs in Australian temperate moist Eucalyptus regnans forests, and (ii) average values of the global site biomass data were higher for sampled temperate moist forests (n = 44) than for sampled tropical (n = 36) and boreal (n = 52) forests (n is number of site...

  11. Comparison of H+ and He+ Plasmapause Locations Based on Resurrected and Reevaluated OGO-5 Ion Composition Data Base

    Science.gov (United States)

    Truhlik, Vladimir; Triskova, Ludmila; Benson, Robert F.; Bilitza, Dieter; Grebowsky, Joseph; Richards, Phil G.; Smilauer, Jan

    2014-01-01

    Orbiting Geophysical Observatory 5 (OGO 5) magnetospheric ion-composition data (H+, He+ and O+) from an ion spectrometer (Sharp, 1969) have been retrieved from old magnetic tapes archived at the National Space Science Data Center (NSSDC). The highly compressed binary format was converted into a user-friendly ASCII format and these data have been made available online. We have inspected reliability and consistency of this data set in state of the art current knowledge. Comparing with the climatological model IRI-2012 and the mathematical model FLIP a shift of absolute and relative ion densities with time was revealed. We have suggested a correction procedure of individual H+, He+ and O+ ion densities. Using the corrected data set, we investigated plasmapause locations based on density gradient in H+, and He+. Correlation coefficient of both locations was determined as approx. 0.886 and the typical difference (Delta)L approx. 0.1. The electron density at the He+ plasmapause location for all cases is >100/cu cm.

  12. 77 FR 43143 - Limitation on Claims for Judicial Review; Re-Evaluation With Respect to the Willits Bypass...

    Science.gov (United States)

    2012-07-23

    ... Willits Bypass Project, Willits, CA AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of... to the State Route 101 Willits Bypass Project in Willits (Mendocino County), California, two Re... resulting from the new information and proposed changes to the Willits Bypass Project and in order...

  13. Reevaluation of the Correlation between Angiotensinogen Gene M235T Polymorphism and Familial Essential Hypertension Using MS-PCR Technique

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective Using mutagenically separated allele-specific polymerase-chain-reaction (MS-PCR) technique to determine the correlation between angiotensinogen gene M235T (Ag TM235T) polymorphism and the onset of familial essential hypertension in the population from Jiangsu and Anhui Provinces. Methods (1) Establish and compare the optimal reaction system of PCR-RFLP and MS-PCR technique to detect AgTM235T polymorphism. (2) All subjects were divided into four groups: 62 patients with both hypertension and familial background (FH), 32 normal persons who had familial background (FNH), 26 persons in control group (N) and 10 patients with hypertension but without familial background (NFH group). The genotype of all subjects was determined by MS-PCR technique.Results (1) The frequency of T allele in PCR-RFLP was 0.5, much lower than 0.95 in MS-PCR, which was demonstrated by DNA sequencing. (2) The TT-genotype and the frequency of T allele (TT/T) in FH and FNH groups were much higher than those in N and NFH groups (0.581/0.766 and 0.563/0.766 vs 0.346/0.577 and 0.40/0.550, P<0.005). (3) Persons developing hypertension in FNH group were much younger than other three groups (28.07±9.72 , P<0.025). Conclusion (1) Compared with PCR-RFLP, MS-PCR is a rapid, simple and reliable technique for detection gene polymorphism of Ag TM25T. (2) In Jiangsu and Anhui area, the present study confirms the observation of a higher frequency of the 235T allele of the angiotensinogen gene in hypertension and identifies individuals with family history. Concerning of the age, we might speculate that the AgTM235T polymorphism is only associated with familial essential hypertension.

  14. New modalities (setting, fractionation) of radioimmunotherapy by {sup 90}Y-ibritumomab tiuxetan ({sup 90}Y zevalin) in first line treatment of follicular type non Hodgkin malignant lymphomas: efficiency, toxicity and personalized dosimetry approach; Nouvelles modalites (consolidation, fractionnement) de radioimmunotherapie par {sup 90}Y-ibritumomab tiuxetan (Zevalin) en traitement de premiere ligne des lymphomes malin non hodgkiniens de type folliculaire: efficacite, toxicite et approche dosimetrique personnalisee

    Energy Technology Data Exchange (ETDEWEB)

    Morschhauser, F

    2008-12-15

    Rationale: radioimmunotherapy (R.I.T.) with {sup 90}Y-ibritumomab tiuxetan ([{sup 90}Y] Zevalin ) is a new treatment option for patients with relapsed/refractory non Hodgkin follicular lymphoma (F.L.). Efficacy increases when Zevalin is used earlier in the disease course. Currently, Zevalin dosage is based on weight and not dosimetry. This most likely results in a wide range of absorbed dose to critical organs and tumor, which in turn translates in unpredictable efficacy and toxicity. Optimizing R.I.T. with [{sup 90}Y] Zevalin will require its use as part of first-line therapy and implementation of patient-specific dosimetry methods in clinical trials. Objectives and methods: we have consecutively studied 2 new modalities of using Zevalin in first line therapy of F.L.. First, we conducted an international, randomized, phase 3 trial to evaluate the efficacy and safety of consolidation with Zevalin(15 MBq/Kg) in patients with advanced-stage F.L. achieving at least a partial response after induction immuno chemotherapy. A second approach consisted of evaluating a fractionated schedule with 2 doses of Zevalin (11.1 MBq/kg each), 9 to 13 weeks apart, as front line therapy in F.L. patients with high tumor burden. As part of this second approach, we designed a refined imaging-based (planar and 3-dimensional) dosimetry protocol to improve prediction of dose efficacy and toxicity after each dose of zevalin. Data acquisition was performed in 3 centers (Lille, Nantes and Manchester) while data treatment and specific dose calculations for major organ, tumor masses and bone marrow were centralized. Conclusion: Consolidation of first remission with {sup 90}Y-ibritumomab tiuxetan in advanced-stage follicular lymphoma is highly effective with no unexpected toxicities, prolonging P.F.S. by 2 years and resulting in high P.R.-to-C.R. conversion rates regardless of type of first-line induction treatment. Preliminary data show the feasibility of front line fractionated R.I.T. with Zevalin in patient with high tumor burden and of implementing a standardized refined data acquisition/treatment protocol for imaging-based dosimetry in the multicenter setting. Dosimetry results obtained for 6 patients who underwent patient-specific quantitative planar imaging after both Zevalin fractions will be presented. (author)

  15. Re-evaluation of the Mentelle Basin, a polyphase rifted margin basin, offshore south-west Australia: new insights from integrated regional seismic datasets

    Directory of Open Access Journals (Sweden)

    D. Maloney

    2011-02-01

    Full Text Available Vintage 2-D (two dimensional seismic reflection surveys from the sparsely explored Mentelle Basin (western Australian margin have been re-processed and integrated with recent high quality seismic survey, and stratigraphic borehole data. Interpretation of these data sets allows the internal geometry of the Mentelle Basin fill and depositional history to be reanalysed with a greater degree of confidence. Basin stratigraphy can be subdivided into several seismically defined megasequences, separated by major unconformities related to both the Valanginian breakup between India-Madagascar and Australia-Antarctica, and tectonically-driven switches in deposition through the Albian.

    Resting on the Valanginian unconformity are several kilometre-scale mounded structures that formed during late Jurassic to early Cretaceous extension. These have previously been interpreted as volcanic edifices, although direct evidence of volcanic feeder systems is lacking. An alternative interpretation is that these features may be carbonate build-ups. The latter interpretation carries significant climatic ramifications, since carbonate build-ups would have formed at high palaeolatitude, ~60° S.

    Soon after breakup, initial subsidence resulted in a shallow marine environment and Barremian-Aptian silty-sandy mudstones were deposited. As subsidence continued, thick Albian ferruginous black clays were deposited. Internally, black clay megasequences show previously unresolved unconformities, onlapping and downlapping packages, which reflect a complex depositional, rifting and subsidence history, at odds with their previous interpretation as open marine sediments.

    Southwestwards migration of the Kerguelen hotspot led to thermal contraction and subsidence to the present day water depth (~3000 m. This was accompanied by Turonian-Santonian deposition of massive chalk beds, which are unconformably overlain by pelagic Palaeocene-Holocene sediments. This substantial unconformity is related to the diachronous breakup and onset of slow spreading between Australia and Antarctica, which may have led to the reactivation and inversion of basement faults, followed by rapid seafloor spreading from the middle Eocene to the present.

  16. Fundamental discrepancies in abortion estimates and abortion-related mortality: A reevaluation of recent studies in Mexico with special reference to the International Classification of Diseases

    Directory of Open Access Journals (Sweden)

    Koch E

    2012-12-01

    Full Text Available Elard Koch,1,2 Paula Aracena,1 Sebastián Gatica,1 Miguel Bravo,1 Alejandra Huerta-Zepeda,3 Byron C Calhoun41Institute of Molecular Epidemiology (MELISA, Center of Embryonic Medicine and Maternal Health, Faculty of Medicine, Universidad Católica de la Santísima Concepción, Concepción, Chile; 2Faculty of Medicine, University of Chile, Santiago, Chile; 3Universidad Popular Autónoma del Estado de Puebla UPAEP, Puebla, México; 4Department of Obstetrics and Gynecology, West Virginia University, Charleston, WV, USAAbstract: In countries where induced abortion is legally restricted, as in most of Latin America, evaluation of statistics related to induced abortions and abortion-related mortality is challenging. The present article reexamines recent reports estimating the number of induced abortions and abortion-related mortality in Mexico, with special reference to the International Classification of Diseases (ICD. We found significant overestimations of abortion figures in the Federal District of Mexico (up to 10-fold, where elective abortion has been legal since 2007. Significant overestimation of maternal and abortion-related mortality during the last 20 years in the entire Mexican country (up to 35% was also found. Such overestimations are most likely due to the use of incomplete in-hospital records as well as subjective opinion surveys regarding induced abortion figures, and due to the consideration of causes of death that are unrelated to induced abortion, including flawed denominators of live births. Contrary to previous publications, we found important progress in maternal health, reflected by the decrease in overall maternal mortality (30.6% from 1990 to 2010. The use of specific ICD codes revealed that the mortality ratio associated with induced abortion decreased 22.9% between 2002 and 2008 (from 1.48 to 1.14 deaths per 100,000 live births. Currently, approximately 98% of maternal deaths in Mexico are related to causes other than induced abortion, such as hemorrhage, hypertension and eclampsia, indirect causes, and other pathological conditions. Therefore, only marginal or null effects would be expected from changes in the legal status of abortion on overall maternal mortality rates. Rather, maternal health in Mexico would greatly benefit from increasing access to emergency and specialized obstetric care. Finally, more reliable methodologies to assess abortion-related deaths are clearly required.Keywords: maternal health, maternal mortality, abortion, estimation methods, developing countries, International Classification of Diseases

  17. Reevaluating the Role of Acanthamoeba Proteases in Tissue Invasion: Observation of Cytopathogenic Mechanisms on MDCK Cell Monolayers and Hamster Corneal Cells

    Directory of Open Access Journals (Sweden)

    Maritza Omaña-Molina

    2013-01-01

    Full Text Available The morphological analysis of the cytopathic effect on MDCK cell monolayers and hamster cornea and qualitative and quantitative analyses of conditioned medium and proteases were evaluated and compared between two strains of Acanthamoeba genotype T4. Further than highlighting the biological differences found between both strains, the most important observation in this study was the fact that proteases both in total extracts and in conditioned medium are apparently not determinant in tissue destruction. An interestingly finding was that no lysis of corneal tissue was observed as it was previously suggested. These results, together with previous studies, allow us to conclude that the invasion and disruption of corneal tissue is performed by the penetration of the amoebae through cell junctions, either by the action of proteases promoting cellular separation but not by their destruction and/or a mechanical effect exerted by amoebae. Therefore, contact-dependent mechanisms in Acanthamoeba pathogenesis are more relevant than it has been previously considered. This is supported because the phagocytosis of recently detached cells as well as those attached to the corneal epithelium leads to the modification of the cellular architecture facilitating the migration and destruction of deeper layers of the corneal epithelium.

  18. The middle-class nature of identity and its implications for education: a genealogical analysis and reevaluation of a culturally and historically bounded concept.

    Science.gov (United States)

    Matusov, Eugene; Smith, Mark Philip

    2012-09-01

    We consider identity as a historically emerging discourse that requires genealogical analysis - not to discover the roots of our identity but to commit [ourselves] to its dissipation (Foucault 1977, p. 162). We suggest analyzing identity through the history of socio-economic classes, their life struggles, ambitions, development, and reproduction. We see learning not as a project of transformation of identity, but rather as developing access to socially valuable practices and developing one's own voice within these practices (through addressing and responding to other voices). The access and voice projects free agents from unnecessary finalization and objectivization by oneself and others (Bakhtin 1999; Bakhtin 1990). In education, we should develop indigenous discourses of learning and develop a conceptual framework that makes analysis of diverse discourses possible. We argue that learning, as transformation of participation in a sociocultural practice to gain more access, is a better conceptual framework than learning as transformation of identity.

  19. Validation and reevaluation of the pathology classification in IgA nephropathy%IgA肾病病理分型的验证与再评价

    Institute of Scientific and Technical Information of China (English)

    师素芳; 张宏

    2013-01-01

    IgA肾病的病理表现复杂多样,一直以来没有一个被广为接受的病理分型.IgA肾病牛津病理分型的制定过程非常严谨和科学,自2009 年发表至今引起了广泛关注,不同国家对该分型进行了验证,但由于入选病例临床表现不同、随访过程中治疗方法不同、种族的差异,以及多为小样本、少终点事件的回顾性研究,因此导致目前验证研究的结果之间存在很大差异.最新的研究通过对目前已有的12 项验证研究进行的荟萃分析,发现系膜细胞增生病变、节段性硬化或粘连病变及肾小管萎缩或间质纤维化病变是影响IgA肾病肾脏预后的独立病理指标,内皮细胞增生病变不是影响肾脏预后的病理指标.IgA肾病病理分型的临床意义和应用价值有待进一步的大样本、多中心、前瞻性研究进行证实.

  20. Anomalous density and elastic properties of basalt at high pressure: Reevaluating of the effect of melt fraction on seismic velocity in the Earth's crust and upper mantle

    Science.gov (United States)

    Clark, Alisha N.; Lesher, Charles E.; Jacobsen, Steven D.; Wang, Yanbin

    2016-06-01

    Independent measurements of the volumetric and elastic properties of Columbia River basalt glass were made up to 5.5 GPa by high-pressure X-ray microtomography and GHz-ultrasonic interferometry, respectively. The Columbia River basalt displays P and S wave velocity minima at 4.5 and 5 GPa, respectively, violating Birch's law. These data constrain the pressure dependence of the density and elastic moduli at high pressure, which cannot be modeled through usual equations of state nor determined by stepwise integrating the bulk sound velocity as is common practice. We propose a systematic variation in compression behavior of silicate glasses that is dependent on the degree of polymerization and arises from the flexibility of the aluminosilicate network. This behavior likely persists into the liquid state for basaltic melts resulting in weak pressure dependence for P wave velocities perhaps to depths of the transition zone. Modeling the effect of partial melt on P wave velocity reductions suggests that melt fraction determined by seismic velocity variations may be significantly overestimated in the crust and upper mantle.