WorldWideScience

Sample records for 2004-5 pelotas rs

  1. Metodologia do estudo da coorte de nascimentos de 1982 a 2004-5, Pelotas, RS Metodologia de estudio de la cohorte de nacimientos de 1982 a 2004-5, Pelotas, Sur de Brasil Methodology of the Pelotas birth cohort study from 1982 to 2004-5, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Fernando C Barros

    2008-12-01

    Full Text Available OBJETIVO: Descrever os métodos utilizados no estudo longitudinal e acompanhamento das crianças nascidas em Pelotas (RS em 1982. MÉTODOS: A coorte foi iniciada com um inquérito de saúde perinatal de todas as 6.011 crianças nascidas nas maternidades de Pelotas em 1982. As 5.914 crianças nascidas vivas foram incluídas nos estudos de acompanhamento. Até 2004-5 foram realizados oito acompanhamentos, com a aplicação de questionários às mães e/ou aos membros da coorte, conforme a faixa etária. Exames antropométricos e clínicos foram realizados nas visitas. Os participantes da coorte são descritos conforme variáveis demográficas, socioeconômicas e de saúde colhidas nos primeiros acompanhamentos, que são utilizadas como variáveis de exposição. RESULTADOS: A maior parte dos jovens da coorte foram acompanhados durante 23 anos de vida e distintas visitas. Os acompanhamentos que obtiveram maior êxito foram aqueles precedidos por um censo da cidade. Com este método foram localizados 87,2% em 1984 (idade média de 19 meses, 84,1% em 2006 (média 43 meses, e 77,4% em 2004-5 (média 23 anos. CONCLUSÕES: Estudos de coorte de nascimentos podem ser realizados com sucesso em países em desenvolvimento, e a metodologia empregada nesses estudos de ciclo vital permite estudar a influência de exposições precoces sobre a determinação das doenças da vida adulta.OBJETIVO: Describir los métodos utilizados en el estudio longitudinal y acompañamiento de los niños nacidos en Pelotas (Sur de Brasil en 1982. MÉTODOS: La cohorte fue iniciada con una investigación de salud perinatal de todos los 6.011 niños nacidos en las maternidades de Pelotas en 1982. Los 5.914 niños nacidos vivos fueron incluidos en los estudios de acompañamiento. Hasta 2004-5 fueron realizados ocho acompañamientos, con la aplicación de cuestionarios a las mamás y/o a los miembros de la cohorte conforme el rango de edad. Exámenes antropométricos y cl

  2. Maternidade e paternidade na coorte de nascimentos de 1982 a 2004-5, Pelotas, RS Maternidad y paternidad en la cohorte de nacimientos de 1982 a 2004-5, Pelotas, Sur de Brasil Maternity and paternity in the Pelotas birth cohort from 1982 to 2004-5, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Denise P Gigante

    2008-12-01

    Full Text Available OBJETIVO: Descrever a prevalência de maternidade e paternidade em adultos jovens e sua associação com variáveis perinatais, socioeconômicas e demográficas. MÉTODOS: Os participantes foram jovens com idade média de 23 anos, acompanhados em estudo de coorte desde o seu nascimento, em 1982, em Pelotas (RS e entrevistados em 2004-5. Foram considerados elegíveis os jovens que referiram ter tido um ou mais filhos, nascidos vivos ou mortos. Dois questionários foram aplicados para coletar informações sobre saúde reprodutiva, dados socioeconômicos e demográficos. As variáveis independentes foram sexo e cor da pele, renda familiar em 1982 e 2004-5, mudança de renda, peso ao nascer do jovem e escolaridade aos 23 anos. Análises brutas e ajustadas foram realizadas por meio de regressão de Poisson para investigar os efeitos das variáveis independentes sobre a maternidade/paternidade na adolescência. RESULTADOS: De 4.297 jovens entrevistados, 1.373 (32% eram mães ou pais, dos quais 842 (19,6% haviam experimentado a maternidade/paternidade na adolescência. O planejamento da gravidez do primeiro filho mostrou relação direta com a idade do jovem. Relação inversa foi observada entre as variáveis socioeconômicas e a ocorrência de maternidade/paternidade na adolescência. A probabilidade de ser mãe na adolescência foi maior entre as mulheres pretas ou pardas, mas a cor da pele não esteve associada com a paternidade na adolescência. CONCLUSÕES: Houve forte relação entre a maternidade/paternidade na adolescência e condições socioeconômicas, a qual deve ser considerada no delineamento de ações preventivas no campo da saúde pública.OBJETIVO: Describir la prevalencia de maternidad y paternidad en adultos jóvenes y su asociación con variables perinatales, socioeconómicas y demográficas. MÉTODOS: Los participantes fueron jóvenes con edad promedio de 23 años, acompañados en estudio de cohorte desde su nacimiento, en 1982

  3. Determinantes sociais da iniciação sexual precoce na coorte de nascimentos de 1982 a 2004-5, Pelotas, RS Determinantes sociales de la iniciación sexual precoz en la cohorte de nacimientos de 1982 a 2004-5, Pelotas, Sur de Brasil Determinants of early sexual initiation in the Pelotas birth cohort from 1982 to 2004-5, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Helen Gonçalves

    2008-12-01

    Full Text Available OBJETIVO: Analisar determinantes sociais da iniciação sexual precoce de jovens pertencentes a uma coorte de nascimentos. MÉTODOS: Foram entrevistados em 2004-5 os indivíduos da coorte de nascimentos de Pelotas (RS, em 1982 (N=4.297. A iniciação sexual precoce (OBJETIVO: Analizar las determinantes sociales de la iniciación sexual precoz de jóvenes pertenecientes a una cohorte de nacimientos. MÉTODOS: Fueron entrevistados en 2004-5 los individuos de la cohorte de nacimientos de Pelotas (Sur de Brasil, en 1982 (N= 4.297. La iniciación sexual precoz (OBJECTIVE: To analyze social determinants of early sexual initiation among young adults from a birth cohort. METHODS: Individuals from the 1982 birth cohort (N=4,297 were interviewed in 2004-5, city of Pelotas, Southern Brazil. Early sexual initiation (<13 years of age was the outcome. Descriptive and stratified analyses were performed according to sex. Variables analyzed were family income in 1982, ethnicity, young adult's level of education and change in income (between 1982 and 2004-5. Ethnographic data were used to complement result analysis. RESULTS: Prevalence of early sexual initiation was higher among black and mixed men, and those with low level of education and low family income in 1982 and 2004-5. More traditional male sexual role requirements, such as virility and sexual initiative, showed more repercussion and adherence from an early age among men. Young family women with higher income and level of education tended to delay their sexual initiation. Imposition of traditional values was found to influence early sexual initiation among men and women with lower level of education and income. CONCLUSIONS: Results found re-established the economic factor as a determinant of behavior or uses of sexuality for both sexes. To focus on political efforts that help the economically disadvantaged to have opportunities and egalitarian future perspectives is an important strategy for health

  4. Educação e trabalho na coorte de nascimentos de 1982 a 2004-5, Pelotas, RS Educación y trabajo en la cohorte de nacimientos de 1982 a 2005, Pelotas, Sur de Brasil Education and work in the Pelotas birth cohort from 1982 to 2004-5, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Fernando C Barros

    2008-12-01

    Full Text Available OBJETIVO: Analisar a influência de fatores socioeconômicos e biológicos precoces ao longo da vida sobre o ingresso na universidade e a inserção no mercado de trabalho dos jovens da coorte de nascimento de 1982. MÉTODOS: Estudo longitudinal de 5.914 nascimentos da cidade de Pelotas (RS, em 1982. Utilizando-se questionários aplicados ao jovem, foram coletadas informações sobre nível educacional e a inserção no mercado de trabalho durante acompanhamento da coorte realizado em 2004-5. Regressão de Poisson foi utilizada para estudar o efeito de variáveis demográficas, socioeconômicas, peso ao nascer e aleitamento materno sobre os desfechos. RESULTADOS: A escolaridade média foi de 9,4 anos (± 3,1 e 42% dos jovens estavam freqüentando a escola em 2004-5. Um de cada cinco jovens havia ingressado na universidade e cerca de dois terços estavam trabalhando no mês anterior à entrevista. O ingresso na universidade foi determinado pelas condições econômicas, e teve influência do peso ao nascer nas mulheres e da amamentação nos homens. A inserção no mercado de trabalho foi mais freqüente entre os homens mais pobres, mas não para as mulheres. CONCLUSÕES: A baixa inclusão universitária e a necessidade de inserção no mercado de trabalho dos jovens de famílias mais pobres mantêm um círculo vicioso que reproduz a hierarquia social dominante.OBJETIVO: Analizar la influencia de factores socioeconómicos y biológicos precoces a lo largo de la vida sobre el ingreso en la universidad y la inserción en el mercado de trabajo de los jóvenes de la cohorte de nacimiento de 1982. MÉTODOS: Estudio longitudinal de 5.914 nacimientos de la ciudad de Pelotas (Sur de Brasil, en 1982. Utilizándose cuestionarios aplicados al joven, fueron colectadas informaciones sobre el nivel educacional y la inserción en el mercado de trabajo durante acompañamiento de la cohorte realizado en 2004-5. Regresión de Poisson fue utilizada para estudiar el

  5. Utilização de serviços de saúde por adultos da coorte de nascimentos de 1982 a 2004-5, Pelotas, RS Utilización de servicios de salud por adultos de la cohorte de nacimientos de 1982 a 2005, Pelotas, Sur de Brasil Pattern of health services utilization by adults of the Pelotas birth cohort from 1982 to 2004-5, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Juvenal S Dias-da-Costa

    2008-12-01

    Full Text Available OBJETIVO: Descrever o padrão de utilização de serviços de saúde por adultos jovens. MÉTODOS: Estudo longitudinal em Pelotas (RS, em que os indivíduos foram localizados no seu nascimento em 1982 e acompanhados até os 23 anos. O desfecho foi definido por informações coletadas sobre consultas com profissionais de saúde realizadas no ano anterior à entrevista entre 2004 e 2005. Os locais de consulta foram categorizados como públicos, privados ou planos de saúde. Análises descritivas foram realizadas para utilização e tipo de serviço de saúde. Regressão de Poisson foi utilizada na análise ajustada. RESULTADOS: Dos entrevistados, 72,0% tiveram consulta com profissionais de saúde no ano anterior à entrevista; 86,2% (IC 95% 84,7;87,7 das mulheres e 59,3% (IC 95% 57,3;61,3 dos homens. Mesmo quando excluídas as consultas com ginecologista, as mulheres continuavam tendo mais consultas do que os homens, 68,4% (IC 95% 66,4;70,4. A utilização dos serviços de saúde foi mais freqüente entre os entrevistados de melhor nível socioeconômico. Diferença de menor uso em relação à cor da pele não branca foi observada somente entre os jovens do sexo masculino. Houve diferenças em relação ao tipo de profissional consultado por homens e mulheres e também conforme a renda familiar. Homens e mulheres consultaram mais freqüentemente o sistema público, os serviços conveniados e em menor proporção o sistema privado. CONCLUSÕES: A situação socioeconômica influenciou a utilização e o tipo de serviço de saúde, com homens e mulheres classificados como "pobres no momento", indicando menor utilização de serviços. Tais diferenças socioeconômicas podem ser indicativas de dificuldades de acesso ao sistema de saúde.OBJETIVO: Describir el patrón de utilización de servicios de salud por adultos jóvenes. MÉTODOS: Estudio longitudinal en Pelotas (Sur de Brasil, en que los individuos fueron localizados en su nacimiento en 1982 y

  6. Methodological aspects of the 1993 Pelotas (Brazil birth cohort study Aspectos metodológicos da coorte de nascimentos de 1993 em Pelotas, RS

    Directory of Open Access Journals (Sweden)

    Cesar Gomes Victora

    2006-02-01

    Full Text Available This paper describes the main methodological aspects of a cohort study, with emphasis on its recent phases, which may be relevant to investigators planning to carry out similar studies. In 1993, a population based study was launched in Pelotas, Southern Brazil. All 5,249 newborns delivered in the city's hospitals were enrolled, and sub-samples were visited at the ages of one, three and six months and of one and four years. In 2004-5 it was possible to trace 87.5% of the cohort at the age of 10-12 years. Sub-studies are addressing issues related to oral health, psychological development and mental health, body composition, and ethnography. Birth cohort studies are essential for investigating the early determinants of adult disease and nutritional status, yet few such studies are available from low and middle-income countries where these determinants may differ from those documented in more developed settings.Descrever aspectos metodológicos do estudo da coorte de crianças que podem ser relevantes para pesquisadores que estejam planejando investigações semelhantes. Em 1993, uma coorte de base populacional foi recrutada em Pelotas, RS. Os 5.249 recém-nascidos nos hospitais da cidade foram acompanhados com um, três e seis meses, e com um e quatro anos de idade. Subestudos estão sendo realizados sobre saúde bucal, desenvolvimento psicológico e saúde mental, composição corporal e aspectos etnográficos. Em 2004-5 foi possível entrevistar 87,5% da coorte inicial, com a idade de 10-12 anos. Estudos de coortes de nascimentos são essenciais para investigar os determinantes precoces da morbidade e estado nutricional de adultos. No entanto, há poucos estudos com esta metodologia em países de renda média e baixa, e alguns dos determinantes da situação de saúde podem ser distintos daqueles observados em países ricos.

  7. Prevalência e determinantes precoces dos transtornos mentais comuns na coorte de nascimentos de 1982, Pelotas, RS Prevalencia y determinantes precoces de los trastornos mentales comunes en la cohorte de nacimientos de 1982, Pelotas, Sur de Brasil Prevalence and early determinants of common mental disorders in the 1982 birth cohort, Pelotas, Southern Brazil

    OpenAIRE

    Luciana Anselmi; Barros, Fernando C; Minten, Gicele C; Gigante, Denise P.; Horta, Bernardo L.; Victora, Cesar G.

    2008-01-01

    OBJETIVO: Estimar a prevalência de transtornos mentais comuns e sua associação com fatores de risco numa coorte de adultos jovens. MÉTODOS: Estudo transversal aninhado à coorte de nascimentos de 1982 de Pelotas, RS. Em 2004-5, 4.297 indivíduos foram entrevistados em visita domiciliar. A probabilidade de transtornos mentais comuns foi estimada pelo Self-Report Questionnaire. Os fatores de risco incluíram variáveis socioeconômicas, demográficas, perinatais e ambientais. A análise foi estratific...

  8. IMPACTOS DO TURISMO NA CIDADE DE PELOTAS/RS, SEGUNDO A COMUNIDADE LOCAL.

    Directory of Open Access Journals (Sweden)

    Dalila Rosa Hallal

    2013-12-01

    Full Text Available O fenômeno atual do rápido crescimento do turismo no mundo vem trazendo algumas importantes reflexões para governos, mercados, pesquisadores, ambientalistas e comunidades. Sabe-se que o turismo pode contribuir sensivelmente para o desenvolvimento sócio-econômico e cultural de amplas regiões e, ao mesmo tempo, em poucos anos, pode degradar o ambiente natural, as estruturas sociais e a herança históricocultural dos povos. Historicamente, é notável o poder das cidades de atrair visitantes. “É uma obra de arte viva e seus atores são seus habitantes. Há cores e odores. Hábitos e costumes. História e memória.” (WAINBERG, 2000, p.13. Com base nestas questões, o presente trabalho tem por objetivo analisar, a partir da comunidade local de Pelotas, as vantagens e desvantagens da atividade turística para a cidade. A coleta de dados foi realizada no município de Pelotas/RS através de entrevistas semiestruturadas com a comunidade local. Este estudo possibilitou a identificação dos principais impactos (econômicos, sociais, ambientais e culturais do turismo na cidade de Pelotas a partir da comunidade local. Os sujeitos identificaram vantagens e desvantagens da atividade turística, sendo as vantagens econômicas e as desvantagens ambientais as mais citadas nas entrevistas

  9. Prevalência e determinantes precoces dos transtornos mentais comuns na coorte de nascimentos de 1982, Pelotas, RS Prevalencia y determinantes precoces de los trastornos mentales comunes en la cohorte de nacimientos de 1982, Pelotas, Sur de Brasil Prevalence and early determinants of common mental disorders in the 1982 birth cohort, Pelotas, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Luciana Anselmi

    2008-12-01

    Full Text Available OBJETIVO: Estimar a prevalência de transtornos mentais comuns e sua associação com fatores de risco numa coorte de adultos jovens. MÉTODOS: Estudo transversal aninhado à coorte de nascimentos de 1982 de Pelotas, RS. Em 2004-5, 4.297 indivíduos foram entrevistados em visita domiciliar. A probabilidade de transtornos mentais comuns foi estimada pelo Self-Report Questionnaire. Os fatores de risco incluíram variáveis socioeconômicas, demográficas, perinatais e ambientais. A análise foi estratificada por sexo e as razões de prevalência simples e ajustadas foram estimadas utilizando-se regressão de Poisson. RESULTADOS: A prevalência de transtornos mentais comuns na população geral foi 28,0%; 32,8% e 23,5%, respectivamente, entre mulheres e homens. Independentemente da pobreza em 1982, homens e mulheres pobres em 2004-5 apresentaram risco aproximado de 1,5 para esses transtornos (pOBJETIVO: Estimar la prevalencia de trastornos mentales comunes y su asociación con factores de riesgo en una cohorte de adultos jóvenes. MÉTODOS: Estudio transversal anidado a la cohorte de nacimientos de 1982 de Pelotas (Sur de Brasil. En 2004-5, 4.297 individuos fueron entrevistados en visita domiciliar. La probabilidad de trastornos mentales comunes fue estimada por el Self-Report Questionnaire. Los factores de riesgo incluyeron variables socioeconómicas, demográficas, perinatales y ambientales. El análisis fue estratificado por sexo y las razones de prevalencia simples y ajustadas fueron estimadas utilizándose regresión de Poisson. RESULTADOS: La prevalencia de trastornos mentales comunes en la población general fue de 28,0%; 32,8% y 23,5%, respectivamente, entre mujeres y hombres. Independientemente de la pobreza en 1982, hombres y mujeres pobres en 2004-5 presentaron riesgo aproximado de 1,5 para esos trastornos (pOBJECTIVE: To estimate the prevalence of common mental disorders and assess its association with risk factors in a cohort of young

  10. Estrutura vertical da troposfera associada com nuvens Cumulunimbus e Nimbustratus em Pelotas, RS The tropospheric vertical structure associated with Cumulunimbus and Nimbustratus cloudiness in Pelotas, RS

    Directory of Open Access Journals (Sweden)

    Natalia Fedorova

    2010-12-01

    Full Text Available As condições termodinâmicas do desenvolvimento de nuvens Cumulunimbus (Cb e Nimbustratus (Ns e formação de precipitações na cidade de Pelotas são estudadas utilizando-se dados do NCEP (National Center for Environmental Prediction, Washington para os níveis padrões e dados meteorológicos convencionais. Analisou-se a freqüência das nuvens Cb e Ns durante três anos, para as quatro estações do ano, e calcularam- se os índices de instabilidade (Showalter, lifted, K and standard totals-totals e a energia potencial de convecção. Foram identificados cinco tipos de perfis verticais de temperatura e umidade para os dias em que foram verificadas nuvens Cb e Ns, através de dados de radiossondagens de Porto Alegre, e das análises do NCEP. Apresentam-se os resultados da análise da instabilidade atmosférica e são discutidos os problemas da previsão de nuvens Cb e Ns, utilizando os índices de instabilidade.The thermodynamic conditions of Cumulunimbus (Cb and Nimbustratus (Ns cloudiness development and precipitation formation in Pelotas city were studied using NCEP (National Centers for Environmental Prediction, Washington data for standard levels and conventional meteorological data. The frequency of the Cb and Ns cloudiness during three years and for each seasons was analyzed. Stability indexes (Showalter, lifted, K and standard totals-totals and the convective available potential energy were calculated. Five types of vertical profiles of temperature and humidity for days with Cb and Ns clouds were identified through radiosonde data over Porto Alegre and NCEP analysis. The results of the atmospheric instability analysis are presented and problems envolving the Cb and Ns cloudiness forecasting, using the stability indexes, are discussed.

  11. SERVIÇO DE ALIMENTOS E BEBIDAS: O CASO DO MERCADO PÚBLICO DE PELOTAS/RS

    Directory of Open Access Journals (Sweden)

    Jacqueline Valle Bairros

    2015-06-01

    Full Text Available Com o crescimento do turismo, cresce a preocupação com o fornecimento de refeições, tanto em qualidade sensorial quanto em qualidade higiênico-sanitária. A cidade de Pelotas, pertence à região Turística da Costa Doce, recebe muitos visitantes que usufruem dos seus serviços turísticos. O Mercado Público Municipal se destaca entre os pontos turísticos de grande visitação por sua localização central e por possuir bancas com os tradicionais doces de Pelotas. Este estudo teve como objetivo realizar um diagnóstico das condições higiênico-sanitárias das lojas de doces do Mercado Público Municipal de Pelotas/RS. Foram verificadas as condições higiênico-sanitárias mediante a aplicação de check list conforme a Portaria nº. 78/2009 da Secretaria da Saúde do Estado do Rio Grande do Sul. A porcentagem geral de conformidades das Lojas de Doces foi de 75,7% e 73,4% sendo, portanto, classificadas como nível Bom (Banca de Doces 01 e Aceitável (Banca de Doces 02. Esses resultados demonstram falhas no processo de produção dos doces, colocando em risco a saúde dos turistas. Conclui-se que, os estabelecimentos necessitam de maior atenção nos serviços com vistas as Boas Práticas de Fabricação.

  12. Immunofluorescent Antibody Test (IFAT for Trypanosoma cruzi in dogs from urban and rural areas of Pelotas, RS

    Directory of Open Access Journals (Sweden)

    Charlene Nascimento dos Santos

    2015-07-01

    Full Text Available Chagas disease (CD is a zoonosis with the protozoan Trypanosoma cruzi as the causative agent. Dogs are considered the main domestic reservoir for T. cruzi in most Latin American countries and in some areas of the United States. In southern Brazil, despite being an endemic area of the disease, the prevalence in dogs is still unknown. This study aimed to evaluate the frequency of T. cruzi antibodies in dogs from urban and rural areas of Pelotas, RS, Brazil. A total of 227 canine sera were used for serological tests, of which 99 were from urban areas and 128 were from rural areas of Pelotas. Information regarding the environment and the possible risk factors (origin, rural contact, age, breed, confinement and gender to which the dogs were exposed were recorded. Indirect immunofluorescence was used to assess the presence of specific immunoglobulins (IgG anti-T. cruzi in the serum of dogs. Of the 227 sera analyzed, 81 (35.7% exhibited anti-T. cruzi, which represented 34.3% of the dogs from the urban area and 36.7% of the dogs from the rural area. Among the variables analyzed, rural contact and male gender showed an association with seropositivity for T. cruzi. The detection of T. cruzi antibodies in the serum of these dogs emphasizes the need to study trypanosomiasis in this important domestic reservoir of Chagas disease.

  13. SEDENTARISMO ENTRE USUÁRIOS DE CENTROS DE ATENÇÃO PSICOSSOCIAL EM PELOTAS-RS: PREVALÊNCIA E FATORES ASSOCIADOS

    OpenAIRE

    Duarte Júnior, Osvaldo

    2011-01-01

    Objetivo: Descrever a prevalência de sedentarismo entre usuários de Centros de Atenção Psicossocial de Pelotas e investigar fatores associados. Métodos: Estudo de delineamento transversal aninhado à uma coorte prospectiva entre os usuários dos CAPS de Pelotas/RS. Utilizou-se um questionário padronizado contendo questões pré-codificadas. A variável dependente foi o sedentarismo no lazer, avaliado através do Questionário Internacional de Atividade Física (IPAQ) na versão curta...

  14. Stochastic modeling: temperature forecast for the city of Pelotas/RS/Brazil = Modelagem estocástica: previsão das temperaturas para a localidade de Pelotas/RS/Brasil.

    Directory of Open Access Journals (Sweden)

    Rita de Cássia Fraga Damé

    2014-04-01

    Full Text Available - The knowledge of temperature from the agronomic viewpoint is important for the growth and development of plants as well as for agricultural production. However, the availability time series is not always available in a way that would allow characterizing the behavior of the interest variable over time. In this sense, the aim of modeling the series of average minimum, maximum temperature and average annual agricultural weather season located in Pelotas, Brazil, in the period 1931- 2011, using the autoregressive models and from the adequacy of the selected model, perform the prediction variable. For both tests Cox- Stuart, Wald-Wolfowitz Spearman and Mann-Kendall were used to prove or disprove the existence of the series of temperature trend over time. The Autoregressive Integrated Moving Average was used as a modeling method and the Porteau Monteau test was used in order to select the fittest model. The non-parametric Spearman test was considered the most robust for the detection of trend in time series, which allowed us to observe an increase of 1.12ºC in the annual minimum of the study site, average temperatures. The annual minimum of Pelotas average temperatures can be predicted by autoregressive models - AR (1, the inclusion of other regressive parameter showed no information gain in forecast of annual average minimum temperatures. Resumo - O conhecimento da temperatura do ponto de vista agronômico é importante para o crescimento e desenvolvimento das plantas, assim como para a produção agrícola. No entanto, nem sempre tem-se a disponibilidade de séries temporais, de forma que caracterize o comportamento da variável de interesse ao longo do tempo. Nesse sentido, objetivou-se modelar as séries de temperaturas médias mínima, máxima e média anual da estação agroclimatológica localizada em Pelotas, RS, Brasil, no período de 1931 a 2011, utilizando os modelos autorregressivos e, a partir da adequação do modelo selecionado

  15. Espinheira-santa (Maytenus ilicifolia Mart. ex Reiss.: saber de erveiros e feirantes em Pelotas (RS

    Directory of Open Access Journals (Sweden)

    C. ALMEIDA

    2015-01-01

    Full Text Available RESUMO O objetivo deste trabalho é descrever o conhecimento popular relacionado à espinheira-santa (Maytenus ilicifolia entre erveiros e feirantes que comercializam a planta no centro de Pelotas, Rio Grande do Sul, Brasil. Foi realizada uma pesquisa de abordagem qualitativa, exploratória e descritiva, de agosto a outubro de 2013. Entrevistas semi-estruturadas, com questões sobre os saberes e práticas relacionados à espinheira-santa, foram aplicadas a cinco erveiros e três feirantes do mercado informal de plantas medicinais. Para a análise dos dados foi utilizada a proposta operativa de Minayo, sendo Capra o referencial teórico para este estudo. Foi verificado que o saber relacionado ao uso da espinheira-santa é transmitido de geração a geração, embora existam outras fontes de conhecimento. As indicações do uso popular da espinheira-santa com finalidade terapêutica estão relacionadas a distúrbios gástricos, cicatrização e depuração do sangue. As diferentes formas dos sujeitos deste estudo interagirem com o ambiente, com sua família e em outras relações interpessoais resultam em diferentes saberes relacionados à espinheira-santa.

  16. Esporotricose felina com envolvimento humano na cidade de Pelotas, RS, Brasil

    Directory of Open Access Journals (Sweden)

    Xavier Melissa Orzechowski

    2004-01-01

    Full Text Available A esporotricose é uma micose subcutânea, causada pelo fungo dimórfico Sporothrix schenckii. O presente estudo descreve a ocorrência de esporotricose felina na cidade de Pelotas (Rio Grande do Sul - Brasil, e a transmissão para um atendente da clínica veterinária, ocasionada pela arranhadura do animal doente. O felino apresentava deformação do espelho nasal e lesões cutâneas, enquanto o humano apresentava uma lesão ulcerada na região metacarpiana dorsal esquerda. Foram colhidas crostas e/ou exsudato das lesões do felino e do atendente para diagnóstico micológico, os quais foram cultivados em ágar Sabouraud dextrose acrescido de cloranfenicol e incubados a 25 e 37degreesC, durante 10 dias. O isolamento do S. schenckii confirmou o diagnóstico clínico de esporotricose cutânea disseminada no felino e cutânea localizada no atendente. Esta nota pretende alertar profissionais relacionados à clínica de pequenos animais quanto à existência da doença e o alto risco de transmissão pela mordedura e/ou arranhadura de animais infectados.

  17. Listeria spp. no processamento de lingüiça frescal em frigoríficos de Pelotas, RS, Brasil Listeria spp. in the processing of fresh sausages in slaughterhou ses from Pelotas, RS, Brazil

    Directory of Open Access Journals (Sweden)

    Wladimir Padilha da Silva

    2004-06-01

    Full Text Available Alimentos intensamente manipulados, como as lingüiças mistas do tipo frescal são freqüentemente responsáveis pela veiculação de enfermidades transmitidas por alimentos. Devido ao risco à saúde pública que a bactéria Listeria monocytogenes representa, este trabalho teve como objetivo estudar a presença de Listeria spp., em especial de L. monocytogenes, durante o processamento de lingüiças mistas do tipo frescal, em três frigoríficos com inspeção sanitária estadual, em Pelotas-RS. Para isso, analisou-se a matéria-prima utilizada no preparo da lingüiça, os equipamentos da linha de processamento e o produto final. Isolou-se Listeria spp. em 100% das 41 amostras analisadas, nos 3 estabelecimentos estudados. Dentre as diferentes espécies, L. innocua foi aquela isolada com maior freqüência, em 97,6% das amostras, seguida por L. monocytogenes em 29,3% e L. welshimeri em 24,4%. A presença destes microrganismos nas amostras analisadas, em especial no produto final, demonstra a necessidade de readequação nas práticas de limpeza e sanificação das plantas de processamento analisadas, bem como representa risco potencial de listeriose ao consumidor.Food that is highly manipulated, such as fresh sausages, is frequently responsible for spreading food borne diseases. Due to the threat that the bacterium Listeria monocytogenes represents to public health, the aim of this work was to study the presence of Listeria spp., especially Listeria monocytogenes, during processing of fresh sausages, in three slaughterhouses with state food inspection, in the city of Pelotas, Brazil. The raw material used for the sausage elaboration, the equipment used in the processing and the end products were analyzed. The results showed Listeria spp. in 100% of the 41 samples analyzed. Among the different species, L. innocua was the most frequent, isolated from 97.6% of the samples, followed by the L. monocytogenes and L. welshimeri that were isolated from

  18. AVALIAÇÃO DA QUALIDADE FÍSICO-QUÍMICA DO MEL PRODUZIDO NA CIDADE DE PELOTAS/RS

    Directory of Open Access Journals (Sweden)

    Willian RICHTER

    2011-12-01

    Full Text Available O trabalho teve por objetivo avaliar a qualidade físico-química de dezenove amostras de méis produzidas na cidade de Pelotas/RS. Foram realizadas análises de umidade, cinzas, acidez total, açúcares redutores e não redutores, hidroximetilfurfural, condutividade elétrica, reações de Fiehe e Lund. Das dezenove amostras avaliadas, dezoito pela determinação da condutividade elétrica, foram classificadas como sendo mel de melato, mel de castanha ou mistura das mesmas. Em relação às demais análises, uma amostra foi considerada adulterada por apresentar inconformidade em relação ao teor umidade, cinzas, açúcares redutores, reação de Lund e reação de Fiehe confirmada pela quantificação de hidroximetilfurfural. Assim, devido à possibilidade de fraude, deve haver maior fiscalização dos órgãos competentes, quanto à produção e comercialização de mel. O consumidor deverá atentar-se ao adquirir mel em feiras livres e estabelecimentos onde os produtos são comercializados sem certificação.

  19. Biochronostratigraphy and paleoenvironment analysis of Neogene deposits from the Pelotas Basin (well 2-TG-96-RS, Southernmost Brazil

    Directory of Open Access Journals (Sweden)

    WAGNER G. SILVA

    2015-09-01

    Full Text Available This paper presents the integration of micropaleontological (palynology and foraminifera and isotopic (87Sr/86Sr analysis of a selected interval from the well 2-TG-96-RS, drilled on the onshore portion of the Pelotas Basin, Rio Grande do Sul, Brazil. A total of eight samples of the section between 140.20 and 73.50 m in depth was selected for palynological analysis, revealing diversified and abundant palynomorph associations. Species of spores, pollen grains and dinoflagellate cysts are the most common palynomorphs found. Planktic and benthic calcareous foraminifera were recovered from the lowest two levels of the section (140.20 and 134.30 m. Based on the stratigraphic range of the species of dinoflagellate cysts and sporomorphs, a span age from Late Miocene to Early Pliocene is assigned. The relative age obtained from the 87Sr/86Sr ratio in shells of calcareous foraminifers indicates a Late Miocene (Messinian correspondence, corroborating the biostratigraphic positioning performed with palynomorphs. Paleoenvironmental interpretations based on the quantitative distribution of organic components (palynomorphs, phytoclasts and amorphous organic matter throughout the section and on foraminiferal associations indicate a shallow marine depositional environment for the section. Two palynologicals intervals were recognized based on palynofacies analysis, related to middle to outer shelf (140.20 to 128.90 m and inner shelf (115.75 to 73.50 m conditions.

  20. Fatores associados ao consumo regular de refrigerante não dietético em adultos de Pelotas, RS

    Directory of Open Access Journals (Sweden)

    Airton José Rombaldi

    2011-04-01

    Full Text Available OBJETIVO: Analisar fatores associados ao consumo regular de refrigerantes não dietéticos por adultos. MÉTODOS: Estudo transversal de base populacional com 972 adultos (20 a 69 anos do município de Pelotas, RS, realizado em 2006. A freqüência de consumo nos 12 meses anteriores à pesquisa foi medida por meio da pergunta: "em geral desde o do ano passado, quantas vezes tu tomaste refrigerante não dietético?". As respostas categorizadas foram dicotomizadas para fins de análise. Foi considerado consumo regular de refrigerante não dietético a freqüência de cinco ou mais vezes por semana. A associação entre o desfecho e variáveis demográficas, socioeconômicas, comportamentais e nutricionais foi analisada pelo teste qui-quadrado para heterogeneidade e tendência linear e a análise multivariável foi realizada por meio de regressão de Poisson, com variância robusta. RESULTADOS: Cerca de um quinto da população adulta de Pelotas (20,4% ingeria regularmente refrigerante não dietético. Indivíduos do sexo masculino (RP 1,50; IC95%: 1,20;2,00, fumantes atuais (RP 1,60; IC95%: 1,20;2,10 e que consumiam semanalmente lanches (RP 2,10; IC95%: 1,60;2,70 apresentaram maior prevalência de consumo de refrigerantes não dietéticos na análise ajustada. A análise estratificada por sexo mostrou que o consumo regular de frutas, legumes e verduras foi fator protetor ao consumo de refrigerantes entre mulheres (RP 0,50; IC95%: 0,30;0,90. CONCLUSÕES: A freqüência do consumo regular de refrigerantes não dietéticos na população adulta foi elevada, particularmente entre homens, jovens e fumantes.

  1. Fatores associados ao sedentarismo no lazer de adultos na coorte de nascimentos de 1982, Pelotas, RS Factores asociados al sedentarismo en el tiempo de ocio de adultos en la cohorte de nacimientos de 1982, Pelotas, Sur de Brasil Factors associated to leisure-time sedentary lifestyle in adults of 1982 birth cohort, Pelotas, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Mario R Azevedo

    2008-12-01

    Full Text Available OBJETIVO: Analisar fatores relacionados à prática de atividade física e ao sedentarismo no lazer. MÉTODOS: Estudo prospectivo de coorte dos nascidos em 1982 na cidade de Pelotas (RS. Os dados foram coletados no nascimento e na visita em 2004-5, na qual foram avaliados 77,4% dos indivíduos da coorte, totalizando 4.297. Informações sobre a prática de atividades físicas, no período de lazer, foram obtidas por meio do Questionário Internacional de Atividades Físicas. Foram considerados sedentários os indivíduos com escore de prática de atividade física semanal inferior a 150 min. Foram consideradas variáveis independentes: sexo, cor da pele, peso ao nascer, renda familiar no ano do nascimento e mudança de renda entre o nascimento e os 23 anos. A regressão de Poisson com ajuste robusto da variância foi utilizada na avaliação dos fatores de risco para o sedentarismo. RESULTADOS: Os homens relataram 334 min do escore de atividades físicas no período de lazer por semana versus 112 min entre as mulheres. A prevalência de sedentarismo foi de 80,6% entre as mulheres e 49,2% entre os homens. Observou-se tendência de aumento do escore de atividades físicas conforme aumentou a renda ao nascer. Indivíduos atualmente pobres ou que se tornaram pobres na idade adulta foram mais sedentários. CONCLUSÕES: O sedentarismo no período de lazer entre adultos jovens mostrou-se elevado, principalmente no sexo feminino. A atividade física no lazer é determinada pelas condições socioeconômicas atuais.OBJETIVO: Analizar factores relacionados con la práctica de actividad física y al sedentarismo en el tiempo de ocio. MÉTODOS: Estudio prospectivo de cohorte de los nacidos en 1982 en la ciudad de Pelotas (Sur de Brasil. Los datos fueron colectados en el nacimiento y en la visita en 2004-5, en la cual fueron evaluados 77,4% de los individuos de la cohorte, totalizando 4.297. Informaciones sobre la práctica de actividades físicas, en el per

  2. Avaliação nutricional de adultos da coorte de nascimentos de 1982, Pelotas, RS Evaluación nutricional de adultos de la cohorte de nacimientos de 1982, Pelotas, Sur de Brasil Nutritional evaluation follow-up of the 1982 birth cohort, Pelotas, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Denise P Gigante

    2008-12-01

    Full Text Available OBJETIVO: Estimar a prevalência de desnutrição por déficit ou excesso de peso e sua associação com fatores demográficos e socioeconômicos. MÉTODOS: Estudo longitudinal de coorte de jovens nascidos em 1982 em Pelotas, RS. Em 2004-5 foram entrevistados 4.198 dos 5.914 indivíduos dessa coorte, que tiveram suas medidas de peso e estatura coletadas para cálculo do índice de massa corporal (IMC. Definiu-se baixo peso pelo valor de IMC inferior a 18,5 kg/m²; excesso de peso, pelo IMC entre 25 e 30kg/m²; e obesidade pelo IMC>30kg/m². Os efeitos de variáveis socioeconômicas (renda familiar e escolaridade, demográfica (cor da pele, peso ao nascer e amamentação sobre baixo peso, excesso de peso e obesidade foram analisados utilizando regressão de Poisson separadamente para homens e mulheres. RESULTADOS: As prevalências de baixo peso, obesidade e excesso de peso foram 6,0%, 8,2% e 28,9%, respectivamente. Na análise ajustada somente o peso ao nascer manteve-se associado com baixo peso em homens e mulheres. Homens pobres tiveram maior risco de baixo peso, mas ficaram protegidos da obesidade e do excesso de peso. Por outro lado, o risco de obesidade e excesso de peso foi maior entre as mulheres pobres. CONCLUSÕES: Os resultados reforçam a importância da determinação socioeconômica sobre o estado nutricional, chamando atenção como esses fatores agem de forma distinta em homens e mulheres de diferentes situações nutricionais, indicando atenção no que se refere a medidas específicas na prevenção, melhorando o acesso à informação sobre educação alimentar e nutricional para toda população.OBJETIVO: Estimar la prevalencia de desnutrición por déficit o exceso de peso y su asociación con factores demográficos y socioeconómicos. MÉTODOS: Estudio longitudinal de cohorte de jóvenes nacidos en 1982 en Pelotas (Sur de Brasil. En 2004-5 fueron entrevistados 4.198 de los 5.914 individuos de esa cohorte, que tuvieron sus

  3. Prevalência de chiado no peito em adultos da coorte de nascimentos de 1982, Pelotas, RS Prevalencia del silbido en el pecho en adultos de la cohorte de nacimientos de 1982, Pelotas, Sur de Brasil Prevalence of wheezing in the chest among adults from the 1982 Pelotas birth cohort, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Ana M B Menezes

    2008-12-01

    Full Text Available OBJETIVO: Estimar a prevalência de chiado no peito em adultos jovens, explorando o efeito de algumas variáveis sobre a ocorrência desta morbidade. MÉTODOS: Estudo prospectivo de coorte dos nascidos em 1982 na cidade de Pelotas (RS. Foram localizados 4.297 (77,4% dos membros da coorte em 2004-5, cujos dados foram coletados por meio de entrevista, utilizando o questionário ISAAC (International Study of Asthma and Allergies in Childhood Steering Committee. A associação entre o desfecho "ocorrência de chiado no peito nos 12 meses anteriores à entrevista" e variáveis socioeconômicas, demográficas e características ao nascimento foi calculada por análise multivariável utilizando regressão de Poisson. RESULTADOS: A prevalência de chiado no último ano foi de 24,9%. Entre aqueles que relataram chiado, 54,6% referiram dificuldade para dormir e 12,9% para falar devido ao chiado. A prevalência de chiado no peito foi significativamente maior entre as mulheres, mantendo associação na análise ajustada com cor de pele não branca, com história familiar de asma e nível socioeconômico baixo. Entre os homens, não houve associação significativa na análise ajustada para cor de pele e renda familiar ao nascimento; história familiar de asma e pobreza durante a vida mostraram associação significativa com chiado no peito. Para ambos os sexos, não houve associação com as variáveis peso ao nascer e duração da amamentação. CONCLUSÕES: A prevalência de chiado no peito foi alta e as pessoas com renda familiar baixa ao nascer tiveram maior risco de chiado no peito no último ano.OBJETIVO: Estimar la prevalencia del silbido en el pecho en adultos jóvenes, explorando el efecto de algunas variables sobre la ocurrencia de esta morbilidad. MÉTODOS: Estudio prospectivo de cohorte de los nacidos en 1982 en la ciudad de Pelotas (Sur de Brasil. Fueron localizados 4.297 (77,4% de los miembros de la cohorte en 2004-5, cuyos datos fueron

  4. RELATÓRIO DA INTERVENÇÃO DE RESTAURO DE UM LEQUE MANDARIM, ACERVO DO MUSEU MUNICIPAL PARQUE DA BARONESA, PELOTAS-RS

    Directory of Open Access Journals (Sweden)

    Isabel Halfen Torino

    2013-02-01

    Full Text Available O presente relatório descreve as etapas de restauração de um leque chinês do século XIX, acervo do Museu Municipal Parque da Baronesa, localizado em Pelotas-RS. O trabalho observou as técnicas construtivas, a caracterização e o comportamento dos materiais constituintes da peça, concentrando-se na diversidade de matérias primas integradas neste objeto e suas interações no processo de restauro. A intenção deste estudo foi a de contribuir para a conservação e orientar para as práticas adequadas de recuperação de acervos desta tipologia para Pelotas e região.

  5. Respiratory syncytial virus infection in children under one year of age hospitalized for acute respiratory diseases in Pelotas, RS

    Directory of Open Access Journals (Sweden)

    Silvia Elaine Cardozo Macedo

    2003-01-01

    Full Text Available INTRODUCTION: Acute respiratory diseases (ARDs are a major cause of infant morbidity and mortality. OBJECTIVE: The present case-controlled study investigated the hospitalizations by ARDs in children under one year of age and the association with the respiratory syncytial virus (RSV in za Pelotas, RS. METHODS: All children under one year of age hospitalized due to ARDs from August 1997 to July of 1998 were followed-up in the four hospitals of the city. A standardized questionnaire was applied to the children's mother regarding symptoms of the actual illness in addition to social and demographic variables, nutrition, and previous morbidity. The final diagnosis of ARDs was performed by an arbiter (a pediatrician based on the hospital records of the children and the data on the questionnaire. Nasopharyngeal secretions were collected for RSV detection by direct immunofluorescence. RESULTS: The study included 650 children and the annual incidence rate of hospital admissions for ARDs was 13.9%. Admissions showed a seasonal pattern with most of the hospitalizations occurring from July to October. The main causes of admission were: pneumonia (43.7%, bronchiolitis (31.0%, asthma (20.3%, influenza (3.5%, otitis media (0.8% and laryngitis (0.6%. The overall prevalence of RSV was 30.7%, with 40.2% in bronchiolitis, 28.6% in influenza, 27.4% in asthma, 26.3% in pneumonia, and 25% in otitis media. CONCLUSIONS: The results of the present study confirm the high morbidity of ARDs in childhood and the seasonal pattern of ARDs hospitalizations and their association with RSV infection.

  6. Condições higiênico-sanitárias no comércio ambulante de alimentos em Pelotas-RS Hygienic-sanitary conditions of street foods from Pelotas, RS

    Directory of Open Access Journals (Sweden)

    Kelly Lameiro Rodrigues

    2003-12-01

    Full Text Available O comércio de alimentos prontos para o consumo por vendedores ambulantes pode constituir um alto risco para a saúde dos consumidores, visto que as pessoas envolvidas nesta atividade geralmente não tem preparo para a manipulação correta de alimentos. Neste trabalho foram investigadas as condições de preparo e a qualidade higiênico-sanitária de lanches comercializados por vendedores ambulantes em Pelotas. Foram colhidas de 60 estabelecimentos, uma amostra de água, uma da superfície de manuseio e um lanche (cachorro-quente. Nos cachorros-quentes foram realizadas contagens de bactérias aeróbias mesófilas (BAM, Staphylococcus coagulase positiva (STA, coliformes totais (CT, coliformes a 45ºC (CF, e investigada a presença de Salmonella sp. Na água e superfície foram realizadas contagens de BAM, CT e CF. Entre as 60 amostras de cachorros-quentes analisadas, 53%, 48%, 37% e 25% estavam fora do padrão para CT, BAM, STA e CF, respectivamente. Em nenhuma amostra foi detectada a presença de Salmonella. As amostras de água apresentaram apenas 3 (5% amostras fora do padrão para BAM, e 27% e 23% fora do padrão para CT e CF, respectivamente. Em relação às superfícies, 70% foram consideradas insatisfatórias para contagem de BAM e 68% e 67% para CT e CF. Os resultados sugerem que as condições higiênicas existentes em muitos estabelecimentos não são adequadas, o que se reflete em uma proporção relativamente alta de lanches com qualidade microbiológica insatisfatória para o consumo.Street-vending of ready-to-eat (RTE foods can be a risk to the consumers health, since people usually involved in this activity does not have proper knowledge in safe handling of foods. Despite this, only a few studies have been made on the microbiological quality of these foods and places where they are prepared. In this paper we report on the higienic-sanitary quality of hot-dogs sold by street-vendors from Pelotas,RS. Samples of hot-dogs, water and

  7. Elections and political changes in Brazil in the 80’s: an analysis from a sub-national unity (Pelotas, RS

    Directory of Open Access Journals (Sweden)

    Alvaro Augusto de Borba Barreto

    2009-06-01

    Full Text Available It examines how the elections in the 1980s (General, in 82 and 86; local, 82 and 88; presidential, 89, reflected in the city of Pelotas (RS, with the aim to identify and close separations the behavior of voters in the national historical process. The prospect is that these four elections show a party system in the process of fragmentation and rules in transformation, which entailed significant changes in the behavior of voters and the actors chosen to lead the national and local policy.

  8. Determinantes precoces da pressão arterial em adultos da coorte de nascimentos de 1982, Pelotas, RS Determinantes precoces de la presión arterial en adultos de la cohorte de nacimientos de 1982, Pelotas, Sur de Brasil Early determinants of blood pressure among adults of the 1982 birth cohort, Pelotas, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Bernardo L Horta

    2008-12-01

    Full Text Available OBJETIVO: Avaliar os efeitos de exposições ocorridas na gestação ou nos primeiros anos de vida sobre a pressão arterial. MÉTODOS: Estudo de coorte com todas as crianças nascidas em 1982 nas maternidades da cidade de Pelotas, RS. As mães residentes em área urbana foram entrevistadas e as crianças, acompanhadas em diferentes ocasiões. Em 2004-5, buscou-se acompanhar todos os indivíduos da coorte. A pressão arterial foi medida duas vezes, no início e no final da entrevista, com esfigmomanômetro digital de pulso. Foi avaliada a associação entre pressão arterial e as seguintes variáveis: cor da pele; escolaridade materna; renda familiar ao nascer; mudança de renda entre o nascimento e os 23 anos de idade; peso ao nascer e duração da amamentação. A análise de variância foi utilizada para a comparação de médias e os modelos lineares generalizados na análise ajustada. RESULTADOS: Obteve-se a medida da pressão arterial para 4.291 indivíduos, 2.208 do sexo masculino e 2.083 do sexo feminino. A média das medidas da pressão arterial sistólica foi de 117,5±15,0 mmHg e da diastólica, de 73,6±11,5 mmHg. Entre os homens, a pressão arterial sistólica foi maior nos indivíduos de cor da pele preta ou parda e naqueles que nunca foram considerados pobres. A pressão diastólica esteve associada apenas com o peso ao nascer. Entre as mulheres, a pressão arterial sistólica foi maior nas de cor da pele preta ou parda, cuja escolaridade materna era maior ou igual a 12 anos ou com peso ao nascer menor do que 4.000 g. CONCLUSÕES:Para ambos os sexos apenas a cor da pele esteve associada com a pressão arterial. A amamentação não teve efeito em longo prazo sobre a pressão arterial, e para o peso ao nascer e o nível socioeconômico, as associações não foram consistentes.OBJETIVO: Evaluar los efectos de exposiciones ocurridas en la gestación o en los primeros años de vida sobre la presión arterial. MÉTODOS: Estudio de

  9. TURISMO NO ESPAÇO RURAL, PRÁTICAS LOCAIS E IMIGRAÇÃO ITALIANA: O Caminho Colonial do Vinho, Pelotas/RS.

    Directory of Open Access Journals (Sweden)

    Tiaraju Salini Duarte

    2011-11-01

    Full Text Available Resumo: As novas características e funções do espaço rural despertam interesse em diferentes áreas do conhecimento, a partir da década de 1980, devido às transformações que levaram a agricultura a se adaptar às novas exigências do mercado. A multifuncionalidade da agricultura é um fenômeno atual, presente no espaço rural, ou seja, as atividades agrícolas passam a não serem as únicas fontes geradoras de renda para o agricultor. Partindo dessas concepções, o turismo no espaço rural do município de Pelotas/RS, mais especificamente no Distrito do Rincão da Cruz, representa a possibilidade de valorização das paisagens naturais e da herança cultural da imigração italiana presentes no local. Para a população urbana, o espaço rural é lócus de lazer e, simultaneamente, depositário de um saber-fazer em relação aos produtos locais, como a uva e seu processamento. Palavras-chave: Turismo Rural. Imigração italiana. Vitivinicultura. Pelotas/RS

  10. Canine coronavirus (CCoV) in dogs vaccinated and unvaccinated domiciliated in Pelotas, RS, Brazil
    Coronavirus canino (CCoV) em cães vacinados e não vacinados domiciliados em Pelotas, RS

    OpenAIRE

    Geferson Fischer; Gilberto D'Avila Vargas; Cristina Freitas Nunes; Paula Fonseca Finger; Juciane Maria Johann; Clarissa Caetano de Castro; Silvia de Oliveira Hübner

    2010-01-01

    Canine coronavirus (CCoV) has been reported causing enteric disease mainly in young pups. In this study, to investigate immunity and exposure to CCoV, was estimated the frequency of serum antibodies to CCoV in 121 dogs in the Pelotas, South of Brazil, by serum neutralization test (SN): 22 had not been vaccinated, 69 had been vaccinated at least once, and 30 had unknown vaccination history. Antibodies were present in 47,8% (33/69) of the vaccinated dogs, in 45,5% (10/22) of the unvaccinated, a...

  11. PREVALÊNCIA DE SALMONELLA EM PRODUTOS DE FRANGOS E OVOS DE GALINHA COMERCIALIZADOS EM PELOTAS, RS, BRASIL PREVALENCE OF SALMONELLA IN CHICKEN PRODUCTS AND HEN'S EGGS FROM PELOTAS, RS, BRAZIL

    Directory of Open Access Journals (Sweden)

    Ana Cristina Baú

    2001-04-01

    Full Text Available A prevalência de Salmonella em produtos de frangos e ovos de galinhas, os sorovares mais freqüentes e sua sensibilidadea a antimicrobianos, foram investigados em Pelotas, Brasil, no período de maio de 1997 a outubro de 1998. Um total de 124 amostras de produtos de frangos obtidas em supermercados e açougues e 94 amostras de 6 unidades de ovos de galinhas obtidas em supermercados e feiras-livres foram analisadas através do método convencional de cultivo. Entre as amostras de produtos de frangos analisadas, 13 (10,48% continham salmonelas. Os 13 isolamentos de salmonelas realizados foram sorotipificados como S. enteritidis (10, S. anatum (1 e S. enterica subespécie enterica sorovar 3,10:e,h:- (2. Todas as cepas isoladas foram resistentes à penicilina G e sensíveis aos demais antimicrobianos testados. Em amostras de ovos, não foram detectadas salmonelas.The prevalence of Salmonella in chicken products and hen's eggs, the most frequent serovars and their antimicrobial sensitivity, were investigated in the city of Pelotas, Brazil from May 1997 through October 1998. A total of 124 samples of chicken products obtained from local supermarkets and butcher shops, and 94 samples of eggs (6 units each obtained from supermarkets and street vendors, were examined through standard cultivation procedures. Salmonella were detected in 13 (10,48% samples of chicken products. Among the 13 strains of salmonellae isolated, 10 were serotyped as S. enteritidis, 1 was S. anatum and 2 were S. enterica subsp. enterica sorovar 3,10:e,h:-. All strains isolated were resistant to penicillin G and susceptible to the others antimicrobial drugs tested. Hen's eggs were not found contaminated with salmonellae.

  12. Determinantes precoces da glicemia casual em adultos da coorte de nascimentos de 1982, Pelotas, RS Determinantes precoces de la glicemia casual en adultos de la cohorte de nacimientos de 1982, Pelotas, Sur de Brasil Early determinants of random blood glucose among adults of the 1982 birth cohort, Pelotas, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Bernardo L Horta

    2008-12-01

    Full Text Available OBJETIVO: Avaliar o efeito de variáveis socioeconômicas, peso ao nascer, duração da amamentação e mudança de renda sobre a glicemia ao acaso em jovens adultos. MÉTODOS: Estudo sobre coorte de nascidos em 1982, quando os 5.914 nascimentos hospitalares ocorridos na cidade de Pelotas foram identificados e as mães entrevistadas. As crianças, cujas famílias residiam na área urbana da cidade, foram acompanhadas diversas vezes. Em 2004-5, 4.927 indivíduos da coorte foram entrevistados e 3.730 tiveram sangue da polpa digital coletado para medida da glicemia casual. Foi avaliada a associação entre glicemia casual e cor da pele, renda familiar ao nascer, escolaridade materna, mudança de renda entre 1982 e 2004-5, peso ao nascer e duração da amamentação. RESULTADOS: A média da glicemia foi de 97,3±15,1mg/dL, sendo maior entre os homens. Nenhuma das variáveis estudadas esteve associada com a glicemia dos homens. Entre as mulheres, a escolaridade materna, a renda familiar aos 23 anos e o peso ao nascimento estiveram inversamente associados com a glicemia. Contudo, o efeito do peso ao nascer perdeu a significância estatística na análise multivariável. CONCLUSÕES: O peso ao nascer e a duração da amamentação não apresentaram efeito em longo prazo sobre a glicemia casual, apenas a escolaridade materna e a renda atual estiveram associados com a glicemia casual nas mulheres.OBJETIVO: Evaluar el efecto de variables socioeconómicas, peso al nacer, duración del amamantamiento y cambio de renta sobre la glicemia al azar en jóvenes adultos. MÉTODOS: Estudio sobre cohorte de nacidos en 1982, cuando los 5.914 nacimientos hospitalares ocurridos en la ciudad de Pelotas fueron identificados y las madres entrevistadas. Los niños, cuyas familiar residían en el área urbana de la ciudad, fueron acompañadas diversas veces. En 2004-5, 4.927 individuos de la cohorte fueron entrevistados y 3.730 tuvieron sangre de la pulpa digital colectada

  13. Os jornais estudantis Ecos Gonzagueanos e Estudante: apontamentos sobre o ensino secundário católico e laico (Pelotas/RS, 1930 a 1960 - The student newspaper Ecos Gonzagueanos e Estudante: notes on the secondary schools catholic and secular (Pelotas/RS

    Directory of Open Access Journals (Sweden)

    Giana Lange do Amaral, Brasil

    2013-04-01

    Full Text Available O presente texto trata do uso de jornais estudantis como fonte para estudos em História da Educação, bem como da importância da leitura de jornais escolares. Privilegia-se a análise de dois jornais de escolas de ensino secundário católico e laico de Pelotas/RS: o Ecos Gonzagueanos e o Estudante. Nas investigações que abordam as práticas culturais, seus sujeitos e sua produção, os jornais estudantis são considerados elementos potenciais para a apreensão das práticas, dos discursos e do cotidiano escolar. É possível observar valores, costumes e interesses que balizavam as relações dos jovens estudantes, bem como os reflexos das apropriações feitas a partir da cultura escolar da instituição a qual estavam ligados.Palavras-chave: jornais estudantis, fontes históricas, ensino secundário, ensino laico e católico. THE STUDENT NEWSPAPER ECOS GONZAGUEANOS E ESTUDANTE: NOTES ON THESECONDARY SCHOOLS CATHOLIC AND SECULAR (PELOTAS/RS, 1930 A 1960AbstractThis paper discusses the use of student newspapers as a source for studies in history of education, as well as the importance of reading school newspaper. Focuses on the analysis of two newspapers of catholic secondary schools and secular of Pelotas/RS: Ecos Gonzagueanos and Estudante. In investigations that address cultural practices, their subjects and their production, student newspapers are considered potential elements for the seizure of the practices, discourses and daily life at school. You can see the values, customs and interests that oriented the relationships of young students as well as the reflections of the appropriations made from the school culture of the institution to which they were connected.Key-words: student newspapers, historical sources, secondary education, secular and catholic education. LOS PERIÓDICOS ESTUDANTILES ECOS GONZAGUEANOS E ESTUDANTE: NOTAS SOBRE LAS ESCUELAS SECUNDARIAS CATÓLICAS E SECULARES (PELOTAS/RS, 1930 A 1960ResumenEste art

  14. Canine coronavirus (CCoV in dogs vaccinated and unvaccinated domiciliated in Pelotas, RS, Brazil Coronavirus canino (CCoV em cães vacinados e não vacinados domiciliados em Pelotas, RS

    Directory of Open Access Journals (Sweden)

    Geferson Fischer

    2010-12-01

    Full Text Available Canine coronavirus (CCoV has been reported causing enteric disease mainly in young pups. In this study, to investigate immunity and exposure to CCoV, was estimated the frequency of serum antibodies to CCoV in 121 dogs in the Pelotas, South of Brazil, by serum neutralization test (SN: 22 had not been vaccinated, 69 had been vaccinated at least once, and 30 had unknown vaccination history. Antibodies were present in 47,8% (33/69 of the vaccinated dogs, in 45,5% (10/22 of the unvaccinated, and in 43,3% (13/30 of the dogs with unknown historical vaccination. There was no significant relationship between these antibodies and sex, age, habitat, and season of collection. The results proved the circulation of the CCoV among this dog population and indicated that the infection affects a significant group of animals. The large proportion of seronegative vaccinated dogs indicates failure of CCoV vaccine in inducing neutralizing antibodies, suggesting that immunizations to CCoV should be reevaluated. The authors indicate the need for further studies in order to evaluate the impact of the infection caused by CCoV, as well as to propose and evaluate preventive measures. Coronavírus canino (CCoV foi relatado como causa de doença entérica principalmente em cães jovens. Nesse estudo, para investigar imunidade e exposição ao CCoV, foi estimado a frequência de anticorpos em 121 cães de Pelotas, sul do Brasil, pelo teste de soro-neutralização (SN: 22 não haviam sido vacinados, 69 haviam sido vacinados com pelo menos uma dose, e 30 possuíam histórico de vacinação desconhecido. Foram detectados anticorpos em 47,8% (33/69 dos cães vacinados, em 45,5% (10/22 dos não vacinados, e em 43,3% (13/30 dos cães com histórico de vacinação desconhecido. Não houve associação significativa entre os anticorpos e sexo, idade, habitação e estação da coleta. Os resultados confirmam a circulação do CCoV entre essa população de cães e indicam que a infec

  15. Estudo longitudinal das crianças nascidas em 1982 em Pelotas, RS, Brasil: metodologia e resultados preliminares Study in length of children born in Pelotas, Rio Grande do Sul, Brazil, in 1982: metodology and preliminary results

    Directory of Open Access Journals (Sweden)

    César Gomes Victora

    1985-02-01

    Full Text Available Tentou-se acompanhar a morbi-mortalidade e o crescimento de uma coorte de 6.011 crianças urbanas nascidas em 1982 nos hospitais de Pelotas, RS, através de visitas domiciliares aos 12 meses (para uma amostra de 30% das crianças e aos 20 meses (para toda a população. Estas crianças representaram mais de 99% de todos os nascimentos urbanos naquele ano. Foi possível localizar 81% das crianças aos 12 meses e 86% aos 20 meses, devido a uma mudança na estratégia de trabalho de campo. A metodologia empregada e as principais dificuldades encontradas são descritas e as características ao nascer das crianças localizadas no acompanhamento são comparadas com as características das crianças não localizadas. A potencialidade de uso dos dados coletados é exemplificada através de alguns resultados preliminares mostrando as associações entre o peso ao nascer, a renda familiar e o estado nutricional aos 12 meses. O estudo mostra que é possível acompanhar, com uma perda relativamente pequena, uma coorte de crianças com base populacional em uma cidade brasileira de tamanho médio.A cohort of 6,011 urban children born in 1982 in the hospitals of Pelotas, Rio Grande do Sul, was followed up so that their morbidity, mortality and growth could be assessed. These children accounted for over 99% of all births in the city. A 30% sample of the children were visited at home when approximately 12 months old, and the whole population was visited at about 20 months of age. It was possible to locate 81% of the children at 12 months. This proportion increased to 86% at 24 months, due to a change in the logistics of the field work which then included visiting all 69,000 households in the city to locate children whose families had moved within the urban area. The methodology and main difficulties encountered are discussed, and the characteristics at birth of children who were located at the first follow-up visit was compared to those of children lost to

  16. O perfil oftalmológico dos candidatos à carteira de motorista na cidade de Pelotas - RS

    Directory of Open Access Journals (Sweden)

    Duarte Wladimir Ribeiro

    2002-01-01

    Full Text Available Objetivo: Estudar a acuidade visual dos candidatos a condutores de veículos da cidade de Pelotas e sua associação com as características sociodemográficas dos candidatos. Métodos: Foram examinados 1.010 candidatos a condutores em um serviço médico autorizado pelo Detran. Avaliou-se a acuidade visual, com e sem correção, bem como a sua relação com a visão de cores, sexo, idade e profissão dos entrevistados, por meio da análise de freqüências e de teste para associação. Resultados: Deste contingente 73,0% eram do sexo masculino, 65,0% tinham idade entre 18 e 45 anos, 51,4% ocupavam o setor de serviços e 25,0% utilizavam meio de correção visual. Sob o ponto de vista oftalmológico, 0,5% dos entrevistados não poderiam dirigir veículos automotores e 4,7% só poderiam obter habilitação para condução veicular, nas categorias A e B. Mostrou-se associada à acuidade visual baixa a maior longevidade. Conclusão: Baseado nos resultados, sugere-se menor intervalo de tempo para reavaliação visual dos motoristas das categorias C, D e E.

  17. Use of geotechnologies for mapping of subject to flooding areas in urban zones: case study of the urban zone of Pelotas/RS

    Directory of Open Access Journals (Sweden)

    Cláudio Santos da Silva

    2007-12-01

    Full Text Available The subject of this work is the study of the urban zone of Pelotas City, RS, Brazil. In order to reach it, the information about the natural relief of the city area was organized and related to the urban drainage information, to identify inward risk areas, susceptible to inundation. The purpose is to minimize the lack of information related to the subject, intending to promote the composition of an orientation system to the use and occupation of the land, besides the educational aspect. Trough the resources of remote sensing environment and Geographic Position System it was possible to identify the risk, compose a important instrument to define the urban expansion areas, equipment localization and pollution activities. From the results, obtained by digital simulation, it was possible to find out that approximately 37,5% of the urban territory are less than 5 meters high and situated near water, increasing the risk of inundation. It demonstrates the necessity of more accurate diagnosis of draining, related to the land use and occupation planning activities. The practical use of this method, identifying and mapping inundation risk areas, gives evidence of its applicability to other cities.

  18. EFEITO DO FRIO NA BROTAÇÃO DE GEMAS DE PEREIRA (Pyrus communis L. cv. Carrick, EM PELOTAS, RS EFFECT OF CHILLING ON THE BUD BREAKING OF PEAR CV. CARRICK, IN PELOTAS, RS

    Directory of Open Access Journals (Sweden)

    FLÁVIO GILBERTO HERTER

    2001-08-01

    Full Text Available Objetivou-se, no presente trabalho, identificar a profundidade de dormência e a velocidade de brotação em gemas de pereira, submetidas a diferentes períodos de frio à temperatura de 4ºC ±1. O experimento foi conduzido na Embrapa-Clima Temperado, em Pelotas, em 1999. Em 1º de junho, foram coletados 50 ramos, na cultivar Carrick, com aproximadamente 30 cm de comprimento. Após, foram divididos em 5 lotes de 10 ramos, sendo 4 mantidos a 4ºC± 1, e um em condições ambiente, constituindo, assim, 5 tratamentos: 0 (Testemunha; 272; 544; 816 e 1088 horas de frio (HF. No final de cada tratamento, os ramos foram divididos em pequenas estacas, contendo apenas uma única gema, sendo, após, armazenados em câmara climática a 25ºC ± 1. Avaliou-se a brotação, considerando-se o estádio de ponta verde. A partir destes dados, calculou-se o tempo médio de brotação (TMB, bem como a percentagem de gemas brotadas, em cada um dos tratamentos. Utilizou-se o índice de velocidade de brotação (IVB, para determinar a eficiência da temperatura na brotação das gemas. A profundidade de dormência, das gemas terminais, diminuiu à medida que se aumentou o período de frio. As gemas axilares não foram influenciadas pelo tempo de exposição ao frio. Com base nos dados do IVB e dos coeficientes angulares, as gemas terminais da cv. Carrick necessitam de 800 horas de frio para completar a brotação, nas condições que foram conduzidos os experimentos.The objective for this work was to identify the dormancy depth and the bud-sprouting rate of pear trees kept at chilling conditions (4ºC±1 for different periods. The experiment was carried out using buds of twigs of the previous growth season from a pear orchard of the Embrapa Clima Temperado Research Center. The twigs were collected on June 1, 1999. The treatments were five period of chilling: 0 (control; 272; 544; 816; or 1088 hours at 4ºC±1. At the end of each treatment, the twigs were cut into

  19. Mixed Martial Arts: rotinas de condicionamento e avaliação da aptidão física de lutadores de Pelotas/RS

    Directory of Open Access Journals (Sweden)

    Fabrício Boscolo del Vecchio

    2013-09-01

    Full Text Available O Mixed Martial Arts (MMA carece de informações acerca do sistema de treinos e da aptidão física de seus lutadores, os quais necessitam de elevado condicionamento aeróbio e neuromuscular. Assim, objetivou-se registrar as rotinas de treinamento e mensurar a aptidão física de lutadores de MMA de nível regional. Oito competidores da cidade de Pelotas/RS constituíram a amostra. Realizaram-se: i entrevista semi-estruturada, contendo dez perguntas abertas, ii avaliação neuromuscular, com testes de carga máxima (1RM no supino reto e levantamento terra, e iii avaliação do componente aeróbio, a partir da determinação da velocidade no VO2máx (vVO2máx, cálculo da potência aeróbia máxima (VO2máx e quantificação do tempo limite (TLim. Os resultados indicam que a maioria dos lutadores de Pelotas realiza apenas dois treinos semanais específicos, não utiliza o treinamento de pesos e emprega corridas nas suas sessões de treino. Acerca da aptidão física, os atletas têm IMC de 26,19±26,19 kg/m², 9,47±4,06% de gordura corporal, 1RM de 76,25±10,61 kg no supino reto e de 115±10,69 kg no levantamento terra, VO2máx de 52,5±4,95mL·kg-1·min-1, vVO2máx de 15±1,41 km·h-1 e TLim de 360,75±55 segundos. Conclui-se que a frequência de treinos aeróbios e de força destes lutadores é insuficiente para o MMA, o percentual de gordura corporal deles é baixo e, apesar da aptidão aeróbia moderada, os níveis de força absoluta e relativa destes lutadores são inferiores aos apresentados pela literatura.

  20. Percepção de exposição a cargas de trabalho e riscos de acidentes em Pelotas, RS (Brasil

    Directory of Open Access Journals (Sweden)

    Rosângela C. Lima

    1999-04-01

    Full Text Available OBJETIVO: Investigar a associação entre a percepção de exposição às cargas de trabalho e o risco de acidentes. MÉTODOS: O delineamento do estudo foi o tipo de casos e controles. Os casos (n=264 incluíram os acidentes de trabalho típicos notificados no Instituto Nacional de Seguridade Social, de Pelotas, RS (Brasil, de janeiro a julho de 1996. Foram excluídos os óbitos (dois, os acidentes ocorridos na zona rural, e os que afastaram o trabalhador de suas atividades por menos de sete dias. Para cada caso foram selecionados três tipos de controles: um trabalhador da mesma empresa, um vizinho e um controle populacional. Os controles foram emparelhados com os casos por idade e sexo e precisavam ter vínculo empregatício formal e não ter sofrido acidente no último mês. Os dados foram analisados usando regressão logística condicional. RESULTADOS E CONCLUSÕES: Os trabalhadores que relatavam enfrentar situações de emergência, o trabalho em altura, perigo constante, ou ambientes ruidosos tinham cerca de duas vezes mais risco de acidentar-se. O trabalho em posições incômodas ou com esforço físico intenso aumentaram em 50% o risco de acidentes. As demais cargas de trabalho estudadas não se constituíram como fatores de risco para os acidentes. Os resultados foram ajustados para fatores de confusão.

  1. Critérios de escolha de postos de saúde para acompanhamento pré-natal em Pelotas, RS

    Directory of Open Access Journals (Sweden)

    Iná S Santos

    2000-12-01

    Full Text Available OBJETIVO: Caracterizar o cuidado pré-natal em uma amostra representativa de mães, identificando o serviço de saúde onde estas realizaram o acompanhamento da gestação e os motivos que as levaram a escolher este local. MÉTODOS: Estudo transversal, realizado nos meses de março e abril de 1997, nas quatro principais maternidades de Pelotas, RS, através de entrevista a 401 mães no pós-parto imediato. RESULTADOS: Fizeram acompanhamento pré-natal, em um posto de saúde 51% das mães, sendo a proximidade geográfica o critério mais freqüentemente referido para tal escolha (46,8%. Para 85% das mães, o serviço de saúde mais próximo de casa era um posto de saúde. No entanto, 52,2% dessas não utilizaram esse local para as consultas pré-natais alegando a má qualidade do atendimento (37,4%. Conforme referido pelas mães, entre os procedimentos de rotina do pré-natal recomendados pelo programa de saúde da rede pública, incluindo a promoção do aleitamento materno, apenas a imunização anti-tetânica foi realizada mais freqüentemente nos postos do que nos demais locais. CONCLUSÕES: Tendo em vista a expressiva utilização da rede pública para o acompanhamento pré-natal, necessitam ser implementados investimentos em educação continuada dos profissionais, com ênfase no cumprimento de normas técnicas pré-estabelecidas.

  2. Critérios de escolha de postos de saúde para acompanhamento pré-natal em Pelotas, RS

    Directory of Open Access Journals (Sweden)

    Santos Iná S

    2000-01-01

    Full Text Available OBJETIVO: Caracterizar o cuidado pré-natal em uma amostra representativa de mães, identificando o serviço de saúde onde estas realizaram o acompanhamento da gestação e os motivos que as levaram a escolher este local. MÉTODOS: Estudo transversal, realizado nos meses de março e abril de 1997, nas quatro principais maternidades de Pelotas, RS, através de entrevista a 401 mães no pós-parto imediato. RESULTADOS: Fizeram acompanhamento pré-natal, em um posto de saúde 51% das mães, sendo a proximidade geográfica o critério mais freqüentemente referido para tal escolha (46,8%. Para 85% das mães, o serviço de saúde mais próximo de casa era um posto de saúde. No entanto, 52,2% dessas não utilizaram esse local para as consultas pré-natais alegando a má qualidade do atendimento (37,4%. Conforme referido pelas mães, entre os procedimentos de rotina do pré-natal recomendados pelo programa de saúde da rede pública, incluindo a promoção do aleitamento materno, apenas a imunização anti-tetânica foi realizada mais freqüentemente nos postos do que nos demais locais. CONCLUSÕES: Tendo em vista a expressiva utilização da rede pública para o acompanhamento pré-natal, necessitam ser implementados investimentos em educação continuada dos profissionais, com ênfase no cumprimento de normas técnicas pré-estabelecidas.

  3. Nível de atividade física entre professores de Educação Física das escolas de educação básica de Pelotas RS

    OpenAIRE

    Canabarro, Lucio Kerber

    2010-01-01

    Estimar o nível de atividade física é importante para o planejamento de intervenções, no entanto há poucos trabalhos que investigam o comportamento de professores neste aspecto. Objetivo: verificar, através de um estudo transversal, o nível de atividade física no lazer dos professores de educação física do ensino básico que atuam na zona urbana da cidade de Pelotas - RS. Método: estudo de caráter censitário, que utilizou o IPAQ (International Physical Activity Questionnarie) lo...

  4. Tabagismo na coorte de nascimentos de 1982: da adolescência à vida adulta, Pelotas, RS Tabaquismo en la cohorte de nacimientos de 1982: de la adolescencia a la vida adulta, Pelotas, Sur de Brasil Smoking prevalence in the 1982 birth cohort: from adolescence to adult life, Pelotas, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Ana M B Menezes

    2008-12-01

    Full Text Available OBJETIVO: Avaliar a prevalência de tabagismo em adolescentes e adultos jovens pertencentes a uma coorte de nascimentos de base populacional. MÉTODOS: Estudo prospectivo de coorte dos nascidos em 1982 na cidade de Pelotas, RS, entrevistados em 1997, 2000-1 e 2005. O desfecho estudado foi o tabagismo, definido como consumo de pelo menos um cigarro na última semana nos acompanhamentos de 1997 e 2000-1. No acompanhamento de 2005, a variável dependente foi tabagismo atual. A análise ajustada foi realizada por meio de regressão de Poisson. RESULTADOS: As prevalências de tabagismo entre homens foram de 5,9%, 20,2% e 27,6% nos acompanhamentos de 1997, 2000-1 e 2005, respectivamente. Os respectivos valores para as mulheres foram 9,3%, 27,5% e 23,6%. A idade média de início do fumo foi de 15,1 anos (dp=2,5. Na análise multivariável, menor escolaridade materna, baixa renda familiar em 1982, ter sido pobre durante todo o período acompanhado e fumo materno na gravidez estiveram significativamente associados com maiores prevalências de fumo em ambos os sexos. A cor da pele não branca associou-se com maior risco de fumo apenas entre as mulheres. A amamentação não mostrou associação com tabagismo. Nas mulheres, o fumo esteve inversamente associado com o peso ao nascer na análise bruta, mas perdeu a significância na ajustada. CONCLUSÕES: A maior concentração de tabagismo nos grupos mais pobres sugere que condutas como o combate ao fumo na gestação e o aumento do preço do cigarro poderiam ter importante impacto populacional.OBJETIVO: Evaluar la prevalencia de tabaquismo en adolescentes y adultos jóvenes pertenecientes a una cohorte de nacimientos de base poblacional. MÉTODOS: Estudio prospectivo de cohorte de los nacidos en 1982 en la ciudad de Pelotas, RS, entrevistados en 1997, 2000-1 y 2005. El desenlace estudiado fue el tabaquismo, definido como consumo de al menos un cigarro en la última semana en los acompañamientos de 1997 y

  5. Uso de medicamentos do nascimento aos dois anos: Coorte de Nascimentos de Pelotas, RS, 2004 Uso de medicamentos desde el nacimiento hasta los dos años: Cohorte de Nacimientos de Pelotas, Sur de Brasil, 2004 Medicine use from birth to age two years: the 2004 Pelotas (Brazil Birth Cohort Study

    Directory of Open Access Journals (Sweden)

    Edilson Almeida de Oliveira

    2010-08-01

    Full Text Available OBJETIVO: Descrever a utilização de medicamentos em crianças aos três, 12 e 24 meses de idade. MÉTODOS: Estudo transversal utilizando dados da Coorte de Nascimentos de Pelotas, RS, de 2004. Foram incluídas 3.985 crianças aos três meses, 3.907 aos 12 meses e 3.868 aos 24 meses de idade. O desfecho considerado foi o uso de medicamentos pelas crianças nos 15 dias anteriores à entrevista. Informações sobre as variáveis independentes (medicamentos utilizados, fonte de indicação, forma de aquisição, regularidade do uso e grupos terapêuticos foram coletadas por meio de questionário padronizado, em entrevista aos pais nos domicílios. RESULTADOS: As prevalências de uso de medicamentos aos três, 12 e 24 meses foram de 65,0% (IC 95%: 63,5;66,5, 64,4% (IC 95%: 62,9;65,9 e 54,7% (IC 95%: 53,1;56,2, respectivamente. Com o avanço da idade observou-se diminuição no número total de medicamentos utilizados e aumento na automedicação, essa última chegando a 34% aos 24 meses. Também, a freqüência do uso de medicamentos em caráter eventual aumentou e diminuiu a de uso contínuo. Os medicamentos foram adquiridos principalmente com recursos próprios e cerca de 10% foi adquirido pelo Sistema Único de Saúde. Observou-se mudança no perfil dos grupos terapêuticos mais utilizados em função da idade. Aos três meses, o maior uso foi de medicamentos dermatológicos (36%; aos 12 meses, de medicamentos para o sistema respiratório (24%; e, aos 24 meses, de analgésicos (26%. Comparando-se o uso aos 24 meses com o dos três meses de idade observou-se diminuição na utilização de: medicamentos destinados ao trato alimentar e metabolismo, aos órgãos dos sentidos, sistema cardiovascular e produtos dermatológicos. Houve aumento na utilização de: medicamentos anti-infecciosos sistêmicos, destinados ao sistema musculoesquelético, ao sistema respiratório, analgésicos, antiparasitários, inseticidas e repelentes. CONCLUSÕES: A

  6. PREVENÇÃO DE DEFEITOS DO TUBO NEURAL: PREVALÊNCIA DO USO DA SUPLEMENTAÇÃO DE ÁCIDO FÓLICO E FATORES ASSOCIADOS EM GESTANTES NA CIDADE DE PELOTAS RS, BRASIL

    OpenAIRE

    Mezzomo,Cíntia Leal Sclowitz

    2006-01-01

    Com o objetivo de determinar a prevalência do uso do ácido fólico e fatores associados, realizou-se um estudo transversal de base populacional nas cinco maternidades da cidade de Pelotas - RS, Brasil. A coleta de dados ocorreu no período de 1° de abril a 15 de agosto de 2006 com 1.450 mulheres. As entrevistas foram realizadas em nível hospitalar por questionário padronizado. A análise estatística se realizou por regressão de Poisson. A prevalência do uso de ácido fólico na gest...

  7. Traumatismos alveolodentários na dentição decídua : estudo epidemiológico em pré-escolares da rede municipal e privada de ensino de Pelotas-RS

    OpenAIRE

    2008-01-01

    Estudos epidemiológicos indicam que as injúrias traumáticas têm se tornado um problema de Saúde Pública. Esta pesquisa teve como objetivo determinar a prevalência e a distribuição dos traumatismos alveolodentários na dentição decídua em crianças de 12 a 71 meses, de ambos os sexos, matriculadas nas escolas municipais e privadas de Educação Infantil da cidade de Pelotas/RS. Com o termo de consentimento livre e esclarecido assinado pelos responsáveis e a aprovação do estudo pelo Comitê de Ét...

  8. Fumicultores da zona rural de Pelotas (RS, no Brasil: exposição ocupacional e a utilização de equipamentos de proteção individual (EPI

    Directory of Open Access Journals (Sweden)

    Jober Buss da Silva

    Full Text Available Objetivou-se identificar o conhecimento dos fumicultores frente à exposição aos riscos ocupacionais e à utilização dos equipamentos de proteção individual (EPI durante sua atividade laboral. Estudo descritivo-exploratório, com abordagem qualitativa, utilizando entrevista semiestruturada com fumicultores do Município de Pelotas (RS. A análise temática evidenciou que os trabalhadores possuem conhecimento superficial sobre os problemas de saúde aos quais estão expostos no seu ambiente laboral. Além disso, ficou claro que os EPI são pouco aceitos pelos fumicultores; que estes trabalhadores fazem uso somente de alguns dos equipamentos, por os considerarem desconfortáveis. Tudo isso associado, ainda, à falta de capacitações. Conclui-se que há necessidade de trabalho educativo nas lavouras de fumicultura.

  9. SEMINÁRIO INTERNACIONAL TURISMO E ARQUEOLOGIA: PATRIMÔNIO CULTURAL E NATURAL –PELOTAS/RS/BRASIL PROMOÇÃO DA REDE INTERINSTITUCIONAL UFPEL-UFSM-IPT PARA O DESENVOLVIMENTO INTEGRADO DA ARQUEOLOGIA, PALEONTOLOGIA,TURISMO CULTURAL, PRESERVAÇÃO E EDUCAÇÃO PA

    OpenAIRE

    Fábio Vergara Cerqueira; Rafael Milheira; Jorge Viana

    2012-01-01

    O Seminário Internacional Turismo e Arqueologia: Patrimônio Cultural e Natural  foi idealizado e promovido pela rede interinstitucional estabelecida entre a Universidade Federal de Pelotas (UFPEL), a Universidade Federal de Santa Maria (UFSM) e o Instituto Politécnico de Tomar (IPT-Portugal), visando ao desenvolvimento de projetos nas áreas de Arqueologia, Paleontologia, Preservação e Educação Patrimonial e Turismo Cultural. Sua realização ocorreu em Pelotas/RS/Brasil, entre 24 e 27 de Novemb...

  10. SEMINÁRIO INTERNACIONAL TURISMO E ARQUEOLOGIA: PATRIMÔNIO CULTURAL E NATURAL –PELOTAS/RS/BRASIL PROMOÇÃO DA REDE INTERINSTITUCIONAL UFPEL-UFSM-IPT PARA O DESENVOLVIMENTO INTEGRADO DA ARQUEOLOGIA, PALEONTOLOGIA,TURISMO CULTURAL, PRESERVAÇÃO E EDUCAÇÃO PA

    Directory of Open Access Journals (Sweden)

    Fábio Vergara Cerqueira

    2012-09-01

    Full Text Available O Seminário Internacional Turismo e Arqueologia: Patrimônio Cultural e Natural  foi idealizado e promovido pela rede interinstitucional estabelecida entre a Universidade Federal de Pelotas (UFPEL, a Universidade Federal de Santa Maria (UFSM e o Instituto Politécnico de Tomar (IPT-Portugal, visando ao desenvolvimento de projetos nas áreas de Arqueologia, Paleontologia, Preservação e Educação Patrimonial e Turismo Cultural. Sua realização ocorreu em Pelotas/RS/Brasil, entre 24 e 27 de Novembro de 2004.

  11. PROJETO DE SALVAMENTO ARQUEOLÓGICO DA ZONA URBANA DE PELOTAS/RS: CATÁLOGO DO MATERIAL ARQUEOFAUNÍSTICO DO SITIO CASA 8

    Directory of Open Access Journals (Sweden)

    Chimene Kuhn Nobre

    2012-10-01

    Full Text Available O presente projeto de pesquisa teve como objetivo estudar os vestígiosarqueofaunísticos revelados pelas escavações realizadas em uma residênciapelotense do séc. XIX. A pesquisa insere-se em um projeto mais amplo,desenvolvido sob responsabilidade do Laboratório de Ensino e Pesquisa emAntropologia e Arqueologia (LEPAARQ/ICH/UFPEL, em parceria com aSecretaria Municipal de Cultura de Pelotas (SECULT, no âmbito do ProgramaBID/Monumenta.12 Trata-se de um projeto de salvamento arqueológico das Casas 2,6 e 8, Casa da Banha e Praça Coronel Pedro Osório, autorizado pela portariaIPHAN No 165, de 2 de Agosto de 2002. Conta com o apoio do CNPQ eFAPERGS.

  12. Ludopedagogia: atendimento recreacional-pedagógico para pediatria do Hospital Universitário São Francisco de Paula - Pelotas/RS

    Directory of Open Access Journals (Sweden)

    Nivia Celoi Ferreira

    2016-03-01

    Full Text Available O respectivo projeto procura apresentar o projeto de extensão universitária do Curso de Pedagogia da Universidade Católica de Pelotas, denominado “Ludopedagogia: atendimento recreacional-pedagógico para pediatria do Hospital Universitário São Francisco de Paula - Pelotas RS”. A proposta apoia-se na perspectiva de que o brincar, no contexto da ludicidade infantil, é um fator relevante para estimular os processos de desenvolvimento humano, a fim de inserir a criança em momentos de descontração e promover habilidades cognitivas, bem como, amenizar as tensões provadas pelo ambiente hospitalar. A presença do brincar e tudo a ele relacionado é um dos fatores que facilitam e proporcionam a adaptação do enfermo ao ambiente hospitalar. Para tanto, é necessária a presença de um responsável (pedagogo para mediar experiências lúdicas e criar um elo entre a magia do brincar e o ambiente familiar. Além da presença deste profissional a proposta visa a participação dos familiares para criar uma situação de bem estar e proporcionar a realização de trocas, desta maneira é possível amenizar a tensão emocional no ambiente hospitalar e promover estratégias para o desenvolvimento infantil.

  13. Relatório das atividades de campo do Projeto de Salvamento Arqueológico do Centro Histórico de Pelotas-RS/Brasil (período 2006-2007

    Directory of Open Access Journals (Sweden)

    Fábio Vergara Cerqueira

    2012-09-01

    Full Text Available O Projeto de Salvamento Arqueológico do Centro Histórico de Pelotas-Rs/Brasil  consiste em uma pesquisa de arqueologia histórica em meio urbano que realiza atividades de levantamento e preservação de sítios arqueológicos desde o ano de 2002. Inicialmente, o projeto foi desenvolvido para atender as demandas do Programa  Monumenta  (o qual prevê a restauração da Praça Cel. Pedro Osório e dos mais imponentes prédios de seu entorno e atuou nos projetos de restauração dos casarões 8 (sítio PSGPe-1, escavado em 2002 e 2 (Sítio PSGPe-2, escavado em 2003. Atualmente, o projeto atende a todas as obras de impactação em prédios históricos e sítios arqueológicos da área urbana pelotense, bem como do patrimônio histórico das áreas periféricas. A responsabilidade  técnica pelo trabalho, junto ao  Instituto do Patrimônio Histórico e Artístico Nacional (IPHAN  -  registrado sob número de processo 01512.000006/2005  –  92  -  é do  Laboratório de Ensino e Pesquisa em Antropologia e Arqueologia da Universidade Federal de Pelotas (LEPAARQ  –  UFPEL,  coordenado pelo  Arqueólogo Dr. Fábio Vergara Cerqueira (CERQUEIRA  et  al., 2004a; CERQUEIRA e LOUREIRO, 2004b. PALAVRAS-CHAVE:  Arqueologia histórica  –  Salvamento Arqueológico  – Pelotas oitocentista

  14. Exame citopatológico de colo uterino em mulheres com idade entre 20 e 59 anos em Pelotas, RS: prevalência, foco e fatores associados à sua não realização Pap smears of 20 - 59 year-old women in Pelotas, Southern Brazil: prevalence, approach and factors associated with not undergoing the test

    Directory of Open Access Journals (Sweden)

    Arnildo A. Hackenhaar

    2006-03-01

    Full Text Available OBJETIVO: Determinar a prevalência e o foco de realização do exame citopatológico do colo uterino e também fatores associados à sua não realização em mulheres com idade entre 20 e 59 anos residentes na cidade de Pelotas, RS. MÉTODOS: Entre outubro e dezembro de 2003 foi realizado um estudo transversal de base populacional. Através de amostragem por conglomerados foram sorteados 144 setores censitários em múltiplos estágios. Foram investigadas variáveis sociodemográficas e a realização de exame citopatológico do colo uterino. RESULTADOS: Dentre as 1404 mulheres que constituem a população-alvo dos programas de prevenção do câncer do colo uterino, 83,0% realizaram o exame citopatológico do colo uterino nos três anos antecedentes a este estudo. Mostraram-se significativamente associadas (POBJECTIVE: This study aims to determine the prevalence of and approach of Pap smear tests, as well as associated factors in women living in Pelotas, RS, Southern Brazil, within the 20 - 59 age range, who did not undergo a Pap smear. METHODS: A cross-sectional population-based study was carried out from October to December 2003. 144 census tracts were sampled through a multiple-stage clustered method. Socio-demographic variables were investigated, as well as women's Pap smear tests. RESULTS: Among the 1,404 women who were the target population included in the early detection program of uterine cervix cancer, 83% had had Pap smears in the three years before the study. Variables statistically associated (p<0.05 with women not undergoing the test in the previous three years were: ages ranging from 20-29 to 50-59 years compared with 40-49 year-old women, lower schooling level, lower social level, mixed and black skin color, not having seen a gynecologist in the previous 12 months. CONCLUSIONS: Although this study presents a high coverage of women undergoing Pap smears, women that present higher risk factors for this type of cancer had fewer

  15. USERS’ PERCEPTIONS OF SAFETY IN LOW-INCOME SOCIAL HOUSING – THE CASE STUDY OF “RESIDENCIAL PORTO”, PELOTAS, RS

    Directory of Open Access Journals (Sweden)

    Mateus Treptow Coswig

    2010-11-01

    Full Text Available The subject of safety in low-income social housing challenges architectural and urban planning researches when related with the study of the relationship between environment and behaviour with the following aspect: the benefits that physical and spatial solutions can bring to decrease and prevent crimes and robberies in these places. In Pelotas, the social housings built by “Programa de Arrendamento Residencial” (Residential Leasing Program have been studied in regard to this perspective, seeking to evaluate solutions of design and insertion of safety elements. Methods of research/ Approach: The case study is “Residencial Porto”, built by Residential Leasing Program in 2004, which has blocks built in the limit of the plot creating potential insecurity situations for 12 flats on the ground floor. Through the fieldwork, where methods and techniques of Post Occupancy Evaluation (POE were applied, it is analysed data regarding residents´ perceptions of safety and solutions to increase safety. Results: Residents who live in flats that look at the public road have different perceptions of safety in comparison with the other residents; in this way there are flats on the fourth floor with fences on the windows. Contributions/Originality: This study seeks to identify and analyse residents´ perceptions of safety and safety solutions adopted after the social housing construction was concluded.

  16. FLORÍSTICA E ANÁLISE DE SIMILARIDADE DE ESPÉCIES ARBÓREAS DA MATA DA PRAIA DO TOTÓ, PELOTAS, RS, BRASIL

    Directory of Open Access Journals (Sweden)

    Tiago Schuch Venzke

    2012-01-01

    Full Text Available The floristic survey of tree species was performed in a 'Restinga' forest, municipality of Pelotas, Rio Grande do sul State, Brazil. The area studied is known as 'Mata da Praia do Totó'('Totó' beach forest, and comprises a remnant formed by a sandy and turf 'Restinga' forest. A total 65 native species were sampled comprising 51 genera distributed in 34 families. The family with the greatest number of species was Myrtaceae, with ten species, followed by Salicaceae and Rubiaceae. The most representative genera were Myrsine and Eugenia, respectivelly sampled with four and three species. The analysis of similarity sampled that the sandy forest is floristically related to riparian and hillside forests and the forest peat is related to other forests located in areas of permanent water saturation of soil. Species richness of the site is high for 'Restinga' forests in Rio Grande do Sul state, probably due to the influence of forests located in Serra dos Tapes and by diversity of the environments that make up the study area.

  17. Qualidade da dieta de jovens aos 18 anos de idade, pertencentes à coorte de nascimentos de 1993 da cidade de Pelotas (RS, Brasil

    Directory of Open Access Journals (Sweden)

    Cristina Bossle de Castilhos

    2015-11-01

    Full Text Available O objetivo deste artigo é descrever a qualidade da dieta de adolescentes segundo fatores sociodemográficos e comportamentais. Estudo transversal com 3.959 adolescentes de dezoito anos de idade, pertencentes à coorte de nascimentos de 1993, de Pelotas, Rio Grande do Sul, Brasil. O consumo alimentar foi avaliado através de um Questionário de Frequência Alimentar semiquantitativo, com período recordatório de 12 meses. A qualidade da dieta foi avaliada através do Índice de Qualidade da Dieta Revisado (IQD-R. Este índice varia de 0 a 100 pontos e quanto maior a pontuação, melhor a qualidade da dieta. A média geral do escore do IQD-R foi de 62,4 pontos (DP 12. Adolescentes com cor da pele não branca (63,1, provenientes de familias cujos chefes tinham menor escolaridade (63,6 e pertencentes ao menor quintil do índice de bens (64,7 apresentaram maiores médias no escore do IQD-R. Menores médias foram encontradas entre adolescentes que fumavam (58,5 e que consumiam bebida alcoólica (56,0. Este estudo mostrou que a qualidade da dieta dos adolescentes avaliados merece atenção, especialmente no que se refere à ingestão de vegetais, leites e derivados.

  18. Qualidade da dieta de pré-escolares de 2 a 5 anos residentes na área urbana da cidade de Pelotas, RS

    Directory of Open Access Journals (Sweden)

    Katharine Konrad Leal

    2015-09-01

    Full Text Available ResumoObjetivo:Avaliar a qualidade da dieta de pré-escolares residentes na área urbana da cidade de Pelotas, Rio Grande do Sul, Brasil.Métodos:A qualidade da dieta foi avaliada de acordo com o Índice de Alimentação Saudável (IAS, adaptado para o Brasil. O consumo alimentar foi medido por meio de Questionário de Frequência Alimentar. O escore do índice foi obtido por uma pontuação distribuída em 13 grupos alimentares, que caracterizam diferentes aspectos de uma dieta saudável, variação de 0 a 100 pontos. Quanto mais próximo de 100, melhor será a qualidade da dieta.Resultados:A qualidade da dieta foi avaliada em 556 pré-escolares. O valor médio do escore do IAS foi de 74,4 pontos. Isso indica que as dietas necessitam ser melhoradas. As médias dos escores foram significativamente maiores entre as meninas e entre crianças provenientes de famílias com renda familiar entre um e menos de três salários mínimos mensais.Conclusões:As crianças apresentaram consumo de verduras e legumes abaixo da recomendação, enquanto os alimentos do grupo dos óleos e gorduras, bem como do grupo dos açúcares, balas, chocolates e salgadinhos, foram consumidos em excesso. É importante reforçar orientações para promover um hábito alimentar mais saudável, que poderá perdurar em etapas posteriores da vida

  19. Produção e qualidade do leite na bacia leiteira de Pelotas-RS em diferentes meses do ano

    Directory of Open Access Journals (Sweden)

    Martins Paulo Ricardo Garcia

    2006-01-01

    Full Text Available Avaliou-se a variação da produção e qualidade do leite, durante 11 meses do ano através do monitoramento de nove unidades produtoras de leite (UP, escolhidas aleatoriamente por pertencerem à bacia leiteira de Pelotas. Foram realizadas coletas mensais de leite e dos alimentos de cada UP. Foram avaliadas as características físico-químicas e contagem de células somáticas do leite, além da incidência de mastite e a produção média de leite das UP. As UP foram classificadas nos seguintes sistemas de produção: especializadas, semi-especializadas e não especializadas conforme critérios previamente estabelecidos. Na análise da variância, foram considerados os efeitos de sistemas de produção, meses do ano e a interação entre sistemas e meses do ano, segundo um delineamento completamente casualizado em arranjo fatorial. Foram observadas diferenças no leite produzido nos diversos meses do ano, quanto à produção de leite corrigida, proteína bruta, teor de caseína, teor de lactose, extrato seco total, extrato seco desengordurado e incidência de mastite, não sendo observadas, neste estudo, diferenças quanto às percentagens de gordura e nitrogênio não protéico do leite nem contagem de células somáticas. Nos meses de outono e inverno, ocorreram as menores produções de leite e menores teores dos componentes químicos, enquanto a ocorrência de mastite foi mais importante nos meses de primavera - verão.

  20. Nutrição materna e duração da amamentação em uma coorte de nascimento de Pelotas, RS

    Directory of Open Access Journals (Sweden)

    Gigante Denise Petrucci

    2000-01-01

    Full Text Available OBJETIVO: Os efeitos da situação nutricional materna sobre a duração da amamentação são inconsistentes na literatura. O estudo realizado objetivou investigar esses efeitos em uma coorte de nascimentos hospitalares. MÉTODOS: Foram estudadas 977 mulheres que tiveram filhos no ano de 1993, em Pelotas (representando 20% dos nascimentos ocorridos nesse ano. Os efeitos da situação nutricional materna e de variáveis socioeconômicas e demográficas sobre a prevalência de amamentação aos seis meses de idade e sobre a duração da amamentação foram analisados pela regressão logística e de Cox, respectivamente. RESULTADOS: A análise multivariada mostrou que a prevalência de amamentação foi mais alta entre mulheres que iniciaram a gestação com 49 kg ou mais (RO = 1,31; IC95% 1,04 - 1,64, e a associação com altura materna foi no limiar da significância (p=0,06. A regressão de Cox mostrou um efeito protetor, no limiar da significância, do maior peso pré-gestacional sobre o desmame (RR = 0,91; IC95% 0,82 -- 1,01. Não houve diferença na duração da amamentação quanto à altura materna. O ganho de peso gestacional não mostrou associação com prevalência ou duração da amamentação. Idade materna, paridade, hábito de tabagismo e idade gestacional estiveram associadas significativamente com a amamentação em ambas as análises. Renda familiar mostrou associação com a prevalência de amamentação aos seis meses e o peso ao nascer com a duração da amamentação. CONCLUSÕES: Peso pré-gestacional foi um melhor preditor para duração da amamentação do que o ganho de peso gestacional.

  1. Escherichia coli verotoxigênica: isolamento e prevalência em 60 propriedades de bovinos de leite da região de Pelotas, RS, Brasil Verotoxin-producing Escherichia coli: isolation and prevalence in 60 dairy cattle farms from Pelotas-RS, Brazil

    Directory of Open Access Journals (Sweden)

    Cecília Nunes Moreira Sandrini

    2007-02-01

    Full Text Available A produção de verotoxinas foi investigada em 1.127 isolamentos de Escherichia coli feitos a partir de 243 bovinos de leite, de água de consumo humano e animal e de amostras de leite de 60 propriedades da bacia leiteira de Pelotas, no período de dezembro de 1999 a dezembro de 2000, com o objetivo de determinar a prevalência de E. coli verotoxigênicas (VTEC nas propriedades e no rebanho, de detectar a presença de sorotipos ligados a infecções humanas e de identificar, nas propriedades e na região de Pelotas, potenciais fatores de risco de infecção para os animais. A detecção das toxinas em sobrenadante de culturas de E. coli isoladas foi realizada através do ensaio de citotoxicidade em células Vero. VTEC foi isolada em 95% (57/60 das propriedades estudadas, em 49% (119/243 dos animais testados, em 5% (3/60 das amostras de água de consumo humano, em 8,35% (5/60 das amostras de água de consumo animal e em 5% (3/60 das amostras de leite. A prevalência de bovinos infectados em cada propriedade variou de 0 a 100%. Em 2,9% (7/243 dos animais testados, foram isoladas VTEC pertencentes aos sorogrupos O157, O91 e O112, que incluem cepas responsáveis por casos de colite hemorrágica e síndrome urêmica hemolítica em humanos. Fatores de risco de contaminação, como a precipitação pluviométrica, a temperatura, o tamanho da propriedade e a concentração de animais, apresentaram evidências de influenciarem a prevalência de VTEC nos animais. Estes resultados sugerem que o grupo VTEC está amplamente distribuído na bacia leiteira de Pelotas e inclui organismos pertencentes a sorogrupos patogênicos para humanos.The production of verotoxin was investigated in 1127 Escherichia coli isolated from 243 dairy cattle, water for human and animal consumption, and milk samples from 60 dairy farms from Pelotas-Brazil, from December of 1999 to December of 2000, to determine the prevalence of verotoxigenic E. coli (VTEC in farms, to detect the

  2. Alterações Geomorfológicas Derivadas Da Intervenção De Atividades Antrópicas: análise temporal na Bacia do Arroio Santa Bárbara – Pelotas (RS.

    Directory of Open Access Journals (Sweden)

    Adriano Luís Heck Simon

    2010-08-01

    Full Text Available A análise temporal das alterações nas formas do relevo, tendo como base informações espaciais oriundas da cartografia geomorfológica, possibilita a compreensão da gênese dos distúrbios na morfodinâmica e dos impactos ambientais. Assim, este artigo foi desenvolvido com o objetivo de analisar as principais alterações geomorfológicas desencadeadas na bacia do Arroio Santa Bárbara, localizada no município de PelotasRS, durante 41 anos (1965 – 2006. Para avaliar as alterações ocorridas sobre a morfologia, foram elaborados mapas geomorfológicos da área em estudo, referentes aos anos de 1965 e 1995, a partir da interpretação de fotografias aéreas. O cenário de 2006 foi constituído por meio de representações cartográficas, esquematizadas a partir da obtenção de imagens orbitais do software Google Earth TM. A integralização deste mapeamento ocorreu por meio de trabalhos de campo, onde foram constatadas as transformações da morfologia e as feições geomorfológicas artificiais. As atividades antrópicas efetivaram a imposição de mecanismos de controle que alteraram as formas e a estrutura do sistema, agindo, conseqüentemente, sobre os fluxos de matéria e energia. Tais alterações vinculam-se à expansão urbana, ao desenvolvimento das atividades agrícolas e às ações antrópicas pontuais como a mineração e a interceptação dos cursos de água para a construção de reservatórios.

  3. Explorando as múltiplas trajetórias de causalidade: colaboração entre antropologia e epidemiologia na coorte de nascimentos de 1982, Pelotas, RS Explorando las múltiples trayectorias de causalidad: colaboración entre antropología y epidemiología en la cohorte de nacimientos de 1982, Pelotas, Sur de Brasil Exploring multiple trajectories of causality: collaboration between Anthropology and Epidemiology in the 1982 birth cohort, Pelotas, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Dominique P Béhague

    2008-12-01

    Full Text Available OBJETIVO: Embora a relação entre Epidemiologia e Antropologia tenha uma longa história, geralmente, ela tem sido compreendida por meio da integração dos métodos quantitativos e qualitativos em pesquisa. Recentemente, esses dois campos têm convergido para linhas conceituais e teóricas, enfatizando mais a explicação do que a simples descrição dos fenômenos investigados. O objetivo do estudo foi mostrar como a análise de dados etnográficos auxilia na interpretação aprofundada e teórica de dados epidemiológicos. MÉTODOS: As análises antropológicas do artigo foram obtidas usando métodos etnográficos, de 1997 a 2007, de uma amostra pertencente ao estudo de coorte de nascimento de 1982 em Pelotas (RS. As análises etnográficas foram estruturadas de acordo com os resultados de dois artigos epidemiológicos sobre os determinantes de morbidade mental e da idade de iniciação sexual. RESULTADOS E CONCLUSÕES: As análises etnográficas indicam diversos caminhos de influência e causalidade presentes nas associações estatísticas e que correspondem a experiências únicas de grupos específicos. Explorando esses caminhos, observaram-se vários fatores importantes que ajudam a explicar os resultados epidemiológicos, incluindo as respostas dos jovens às experiências de injustiça/desigualdade, o papel da violência na vida diária, os eventos de vida traumáticos, a reclusão social e introversão como resposta as dificuldades vividas, assim como a maturação psicossocial. A colaboração teórica e metodológica entre antropologia e epidemiologia é importante para a saúde pública, pois tem modificado positivamente esses dois campos do saber.OBJETIVO: A pesar de que la relación entre Epidemiología y Antropología tiene una larga historia, generalmente, ella ha sido comprendida por medio de la integración de los métodos cuantitativos y cualitativos en investigación. Recientemente, esos dos campos han convergido en l

  4. Percepção de exposição a cargas de trabalho e riscos de acidentes em Pelotas, RS (Brasil Workers' perception of exposure to occupational hazards and the risk of accidents in a Southern Brazilian city

    Directory of Open Access Journals (Sweden)

    Rosângela C. Lima

    1999-04-01

    Full Text Available OBJETIVO: Investigar a associação entre a percepção de exposição às cargas de trabalho e o risco de acidentes. MÉTODOS: O delineamento do estudo foi o tipo de casos e controles. Os casos (n=264 incluíram os acidentes de trabalho típicos notificados no Instituto Nacional de Seguridade Social, de Pelotas, RS (Brasil, de janeiro a julho de 1996. Foram excluídos os óbitos (dois, os acidentes ocorridos na zona rural, e os que afastaram o trabalhador de suas atividades por menos de sete dias. Para cada caso foram selecionados três tipos de controles: um trabalhador da mesma empresa, um vizinho e um controle populacional. Os controles foram emparelhados com os casos por idade e sexo e precisavam ter vínculo empregatício formal e não ter sofrido acidente no último mês. Os dados foram analisados usando regressão logística condicional. RESULTADOS E CONCLUSÕES: Os trabalhadores que relatavam enfrentar situações de emergência, o trabalho em altura, perigo constante, ou ambientes ruidosos tinham cerca de duas vezes mais risco de acidentar-se. O trabalho em posições incômodas ou com esforço físico intenso aumentaram em 50% o risco de acidentes. As demais cargas de trabalho estudadas não se constituíram como fatores de risco para os acidentes. Os resultados foram ajustados para fatores de confusão.OBJETIVE: The study of the association between workers' perceptions of occupational hazards and the risk of occupational accidents. DESIGN: Case control study. POPULATION: The cases were 264 workers who presented a "typical" occupational accident, registered at the National Institute of Social Security in the city of Pelotas, between January and July, 1996. Fatal accidents (two were excluded, as were those leading to an absence of less than seven days from work. The cases were interviewed in their homes with a standard questionnaire. For each case, three controls were chosen: a fellow-work, a neighbor and a population control. Controls

  5. Critérios de escolha de postos de saúde para acompanhamento pré-natal em Pelotas, RS Criteria for choosing primary health care facilities for prenatal care, Brazil

    Directory of Open Access Journals (Sweden)

    Iná S Santos

    2000-12-01

    Full Text Available OBJETIVO: Caracterizar o cuidado pré-natal em uma amostra representativa de mães, identificando o serviço de saúde onde estas realizaram o acompanhamento da gestação e os motivos que as levaram a escolher este local. MÉTODOS: Estudo transversal, realizado nos meses de março e abril de 1997, nas quatro principais maternidades de Pelotas, RS, através de entrevista a 401 mães no pós-parto imediato. RESULTADOS: Fizeram acompanhamento pré-natal, em um posto de saúde 51% das mães, sendo a proximidade geográfica o critério mais freqüentemente referido para tal escolha (46,8%. Para 85% das mães, o serviço de saúde mais próximo de casa era um posto de saúde. No entanto, 52,2% dessas não utilizaram esse local para as consultas pré-natais alegando a má qualidade do atendimento (37,4%. Conforme referido pelas mães, entre os procedimentos de rotina do pré-natal recomendados pelo programa de saúde da rede pública, incluindo a promoção do aleitamento materno, apenas a imunização anti-tetânica foi realizada mais freqüentemente nos postos do que nos demais locais. CONCLUSÕES: Tendo em vista a expressiva utilização da rede pública para o acompanhamento pré-natal, necessitam ser implementados investimentos em educação continuada dos profissionais, com ênfase no cumprimento de normas técnicas pré-estabelecidas.OBJECTIVE: To describe the prenatal care delivered to a representative sample of mothers, identifying the health care facility they attended and to explore the reasons that led them to choose that specific health facility. METHOD: A cross-sectional study was conducted at four maternity hospitals in Pelotas, in Southern Brazil, from March to April 1997. A total of 401 mothers were interviewed at the hospital, immediately after delivery. RESULTS: The majority of mothers (51% were followed up at a primary health care facility (PHCF. The main reported reason for choosing a PHCF was its geographic accessibility (46

  6. Hábitos alimentares de escolares adolescentes de Pelotas, Brasil

    OpenAIRE

    Neutzling, Marilda Borges; Assunção, Maria Cecília Formoso; Malcon,Maura Cavada; Hallal, Pedro Curi; Menezes, Ana Maria Baptista

    2010-01-01

    OBJETIVO: Descrever a frequência com que escolares adolescentes de Pelotas (RS) estão seguindo as recomendações nacionais para uma alimentação saudável. MÉTODOS: Estudo transversal aninhado a um estudo longitudinal em 2004, incluindo adolescentes de 13 e 14 anos matriculados em 32 escolas públicas de Pelotas (RS). A amostra incluiu 2.209 adolescentes. Para avaliação da frequência de consumo alimentar, foi utilizado questionário proposto pelo Instituto Nacional do Câncer. Foram construídos des...

  7. Padrões de sibilância respiratória do nascimento até o início da adolescência: coorte de Pelotas (RS Brasil, 1993-2004 Wheezing phenotypes from birth to adolescence: a cohort study in Pelotas, Brazil, 1993-2004

    Directory of Open Access Journals (Sweden)

    Adriana Muiño

    2008-06-01

    Full Text Available OBJETIVO: Estudar a prevalência dos padrões de sibilância respiratória e suas associações com variáveis independentes. MÉTODOS: Coorte de nascidos vivos, 1993, Pelotas (RS; subamostra sistemática de 20% da coorte original acompanhada aos 6 e 12 meses e 4 anos; aos 10-12 anos localizou-se 87,5% da coorte original. Definição dos padrões: transitório: chiado até 4 anos e ausência de chiado aos 10-12 anos; persistente: chiado em todos acompanhamentos; início tardio: chiado aos 10-12 anos. Variáveis independentes: gênero; cor da pele; renda familiar; fumo/asma na gravidez; amamentação; infecção respiratória/diarréia (1º ano; alergia e asma na família (4 e 10-12 anos; diagnóstico médico de rinite/eczema (10-12 anos. RESULTADOS: O total da subamostra foi de 897 adolescentes. Prevalência (IC95% dos padrões de sibilância: transitório 43,9% (40,7-47,2;persistente 6,4% (4,8-8,0; de início tardio 3,3% (2,2-4,5. O transitório foi mais freqüente em crianças de famílias de baixa renda, com menor duração da amamentação, relato de infecções respiratórias (1º ano e história familiar de asma (4 anos; o persistente foi quase duas vezes mais freqüente em meninos, em filhos de mulheres com asma na gravidez, com infecções respiratórias (1º ano e história familiar de asma (4 e 10-12 anos; de início tardio mostrou maior prevalência naqueles com asma na família (10-12 anos e diagnóstico médico de rinite (10-12 anos; menor prevalência em quem relatou infecções respiratórias (1º ano e diagnóstico médico de eczema (10-12 anos. CONCLUSÕES: O conhecimento das associações dos padrões sibilantes permite a adoção de medidas preventivas e terapêuticas.OBJECTIVE: To study the prevalence of wheezing patterns and their associations with independent variables. METHODS: Cohort study of live births in 1993 in Pelotas, Brazil. A systematic subsample (20% of the original cohort was evaluated at 6 months, 12 months and

  8. Depressão pós-parto e alterações de sono aos 12 meses em bebês nascidos na zona urbana da cidade de Pelotas/RS Postpartum depression and sleep disorders in 12 month-old babies born in the urban area of Pelotas city

    Directory of Open Access Journals (Sweden)

    Eliane Rozales Lopes

    2010-01-01

    Full Text Available OBJETIVO: Verificar se existe associação entre as alterações no sono dos bebês aos 12 meses de vida e a depressão pós-parto materna. MÉTODOS: Estudo do tipo transversal aninhado a uma coorte. A amostra foi constituída por mulheres que realizaram o acompanhamento pelo Sistema Único de Saúde (SUS, nas unidades básicas de saúde do município de Pelotas, e que tiveram seus partos a partir de junho/2006. Os bebês de 12 meses oriundos dessa gestação também fazem parte da amostra. Para avaliar a presença de sintomas depressivos nas mães, foi utilizada a Edinburgh Postnatal Depression Scale (EPDS e foram investigados os seguintes comportamentos do sono dos bebês: horas de sono por dia, regularidade do horário para dormir e acordar, sono agitado e despertar noturno. Para análise, foi utilizada Regressão de Poisson. RESULTADOS: 35,7% dos bebês possuem alteração no padrão de sono. Após o ajuste ao modelo hierárquico proposto, a alteração no sono infantil manteve associação com a sintomatologia depressiva da mãe (p OBJECTIVE: Verify whether there is association between sleep disorders in babies at 12 months of age and postpartum depression in motherhood. METHODS:Cross sectional study. The sample was made up of women who had done their prenatal medical care at the National Health System (SUS, at the health basic units in Pelotas and who had their deliveries from June, 2006. The 12 month old babies from these women are also part of the sample. In order to assess depressive symptoms in the mothers, Edinburgh Postnatal Depression Scale was used and the following sleeping behaviors of the babies were investigated: hours of sleep per day, regularity of sleep and wake up time, disturbed sleep and night awakening. Poisson Regression was used for the analysis. RESULTS: 35.7% of the babies showed alterations in their sleeping patterns. After adjusting for the proposed hierarchal model, sleep alteration of the babies was still

  9. Prevalência e fatores associados à enxaqueca na população adulta de Pelotas, RS Prevalence and factors associated to migraine in adult population, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Luciane Scherer Pahim

    2006-08-01

    Full Text Available OBJETIVO: A enxaqueca é uma doença de alta prevalência, com importantes repercussões nas atividades diárias dos indivíduos. O objetivo do estudo foi conhecer a distribuição da enxaqueca na população adulta e alguns de seus determinantes. MÉTODOS: Utilizou-se delineamento transversal de base populacional, com amostragem em múltiplos estágios e probabilística. Foram entrevistados 2.715 indivíduos, de 20 a 64 anos, da zona urbana da cidade de Pelotas, Rio Grande do Sul. Aplicou-se um questionário utilizando as recomendações da International Headache Society para a definição do desfecho. As análises bruta e ajustada foram realizadas pela Regressão de Poisson. RESULTADOS: A prevalência de cefaléia e enxaqueca foram respectivamente 71,3% (IC 95%: 69,6-73,0 e 10,7% (IC 95%: 9,4-12,1. As mulheres apresentaram quatro vezes mais enxaqueca do que os homens (16,2% vs 3,9% e indivíduos com cor de pele branca apresentaram risco 1,4 vezes maior do que os de cor não branca. Mulheres em uso de anticoncepcional hormonal apresentaram 1,3 vezes mais enxaqueca do que as que não o usavam. Nível socioeconômico e menstruação regular nos últimos três meses não mostraram associação com enxaqueca. CONCLUSÕES: A enxaqueca é uma doença que afeta principalmente as mulheres, estando associada a cor da pele branca e uso de anticoncepcional hormonal.OBJECTIVE: Migraine is a disease of high prevalence with important impact on people's daily activities. The study aimed at assessing the distribution of migraine in adult population and some of its determinants. METHODS: A cross-sectional population-based study was conducted with a multi-stage and probabilistic sampling. A total of 2,715 individuals aged 20 to 64 years old living in the urban area of the city of Pelotas, Southern Brazil, were interviewed. A questionnaire was applied according to the recommendations of the International Headache Society to define the main outcome. Crude and

  10. Methodological aspects of the 1993 Pelotas (Brazil) Birth Cohort Study

    Science.gov (United States)

    Victora, Cesar Gomes; Araújo, Cora Luiza Pavin; Menezes, Ana Maria Batista; Hallal, Pedro Curi; Vieira, Maria de Fátima; Neutzling, Marilda Borges; Gonçalves, Helen; Valle, Neiva Cristina; Lima, Rosangela Costa; Anselmi, Luciana; Behague, Dominique; Gigante, Denise Petrucci; Barros, Fernando Celso

    2010-01-01

    This paper describes the main methodological aspects of a cohort study, with emphasis on its recent phases, which may be relevant to investigators planning to carry out similar studies. In 1993, a population based study was launched in Pelotas, Southern Brazil. All 5,249 newborns delivered in the city’s hospitals were enrolled, and sub-samples were visited at the ages of one, three and six months and of one and four years. In 2004-5 it was possible to trace 87.5% of the cohort at the age of 10-12 years. Sub-studies are addressing issues related to oral health, psychological development and mental health, body composition, and ethnography. Birth cohort studies are essential for investigating the early determinants of adult disease and nutritional status, yet few such studies are available from low and middle-income countries where these determinants may differ from those documented in more developed settings. PMID:16410981

  11. Typographic Landscapes of Pelotas: initial survey of the collection and some methodological definitions

    Directory of Open Access Journals (Sweden)

    Daniela Velleda Brisolara

    2016-03-01

    Full Text Available This paper presents part of the research “Pelotas Typographic Landscapes: An exploratory study of the typography in the urban space”. The study aims to investigate the different occurrences of typographic landscapes in certain urban areas of the city of Pelotas / RS to better understanding of typography as a historical and cultural information. The research is based on studies of ‘typographic landscapes’ that have been developed in recent years in several Brazilian cities, which presents methods for collecting, processing and analysis of typography data in the urban space. Therefore, the methodology adopted is based on the indications of investigative process already started in this field, such as the establishment of routes and field research records, making adaptations necessary to context. This paper presents samples of survey from two typographical categories performed in a specific region, in addition to the proposed adjustment to the structure of cataloguing and analysis record.

  12. Hábitos alimentares de escolares adolescentes de Pelotas, Brasil Food habits of adolescent students from Pelotas, Brazil

    Directory of Open Access Journals (Sweden)

    Marilda Borges Neutzling

    2010-06-01

    Full Text Available OBJETIVO: Descrever a frequência com que escolares adolescentes de Pelotas (RS estão seguindo as recomendações nacionais para uma alimentação saudável. MÉTODOS: Estudo transversal aninhado a um estudo longitudinal em 2004, incluindo adolescentes de 13 e 14 anos matriculados em 32 escolas públicas de Pelotas (RS. A amostra incluiu 2.209 adolescentes. Para avaliação da frequência de consumo alimentar, foi utilizado questionário proposto pelo Instituto Nacional do Câncer. Foram construídos desfechos baseados nos dez passos para a alimentação saudável propostos pelo Ministério da Saúde do Brasil. RESULTADOS: Os hábitos alimentares saudáveis mais frequentes foram o consumo diário de feijão e leite, relatado por cerca de metade dos adolescentes. Quase metade dos jovens referiu ingerir batata frita e salgadinhos no máximo uma vez por semana. Verificou-se consumo adequado de alimentos conservados e enlatados em 44,6% dos adolescentes. Pouco menos da metade dos jovens (43,6% nunca colocava sal adicional na comida. Quanto ao consumo de doces e outros alimentos ricos em açúcar, constatou-se que aproximadamente um terço deles consumia bolos ou biscoitos no máximo duas vezes por semana. CONCLUSÃO: Verificou-se baixa frequência de hábitos alimentares saudáveis em todos os subgrupos estudados, sendo a frequência mais baixa entre jovens de maior nível socioeconômico e entre as meninas. O hábito alimentar que apresentou mais baixa frequência - 5,3% dos adolescentes - foi o consumo de frutas e verduras cinco ou mais vezes por dia. Políticas públicas de promoção da saúde voltadas à melhoria da alimentação e nutrição dos adolescentes são necessárias e urgentes.OBJECTIVE: This study aimed to describe the extent to which adolescent students living in Pelotas, Brazil, follow the national recommendations for healthy eating. METHODS: A cross-sectional study was undertaken in 2004, nested to a longitudinal project

  13. Strontium isotope stratigraphy of the Pelotas Basin

    Energy Technology Data Exchange (ETDEWEB)

    Zerfass, Geise de Santana dos Anjos, E-mail: geise.zerfass@petrobras.com.br [Petroleo Brasileiro S.A. (PETROBRAS/CENPES/PDGEO/BPA), Rio de Janeiro, RJ (Brazil). Centro de Pesquisas e Desenvolvimento Leopoldo Americo Miguez de Mello; Chemale Junior, Farid, E-mail: fchemale@unb.br [Universidade de Brasilia (UnB), DF (Brazil). Instituto de Geociencias; Moura, Candido Augusto Veloso, E-mail: candido@ufpa.br [Universidade Federal do Para (UFPA), Belem, PA (Brazil). Centro de Geociencias. Dept. de Geoquimica e Petrologia; Costa, Karen Badaraco, E-mail: karen.costa@usp.br [Instituto Oceanografico, Sao Paulo, SP (Brazil); Kawashita, Koji, E-mail: koji@usp.br [Unversidade de Sao Paulo (USP), SP (Brazil). Centro de Pesquisas Geocronologicas

    2014-07-01

    Strontium isotope data were obtained from foraminifera shells of the Pelotas Basin Tertiary deposits to facilitate the refinement of the chronostratigraphic framework of this section. This represents the first approach to the acquisition of numerical ages for these strata. Strontium isotope stratigraphy allowed the identification of eight depositional hiatuses in the Eocene-Pliocene section, here classified as disconformities and a condensed section. The reconnaissance of depositional gaps based on confident age assignments represents an important advance considering the remarkably low chronostratigraphic resolution in the Cenozoic section of the Pelotas Basin. The recognition of hiatuses that match hiatuses is based on biostratigraphic data, as well as on global events. Furthermore, a substantial increase in the sedimentation rate of the upper Miocene section was identified. Paleotemperature and productivity trends were identified based on oxygen and carbon isotope data from the Oligocene-Miocene section, which are coherent with worldwide events, indicating the environmental conditions during sedimentation. (author)

  14. Clubes carnavalescos negros na cidade de Pelotas

    Directory of Open Access Journals (Sweden)

    Loner, Beatriz Ana

    2009-01-01

    Full Text Available O artigo trata da organização negra na cidade de Pelotas, particularmente com relação aos seus clubes carnavalescos, que tiveram seu auge entre os anos de 1920 e 1950. Pretende-se descrever os principais clubes e sua evolução, analisando seu papel e sua importância para a comunidade negra pelotense

  15. Alimentação nos primeiros três meses de vida dos bebês de uma coorte na cidade de Pelotas, Rio Grande do Sul Alimentación en los primeros tres meses de vida de los bebés de una coorte en la ciudad de Pelotas, Rio Grande do Sul (Brasil Feeding during the first three months of life for infants of a cohort in Pelotas, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Cristina Corrêa Kaufmann

    2012-06-01

    Full Text Available OBJETIVO: Estudar o padrão alimentar nos primeiros três meses de vida de crianças nascidas na cidade de Pelotas (RS. MÉTODOS: Estudo de coorte prospectivo com os bebês nascidos entre setembro de 2002 e maio de 2003, na cidade de Pelotas (RS. Incluíram-se 2.741 bebês nas maternidades e uma amostra aleatória de 30% acompanhada no primeiro e terceiro meses de vida. Foram realizadas análises uni, bi e multivariada. Somente as variáveis com pOBJETIVO: Estudiar el estándar alimentar en los primeros tres meses de vida de niños nascidos en la ciudad de Pelotas (RS, Brasil. MÉTODOS: Estudio de coorte prospectivo con bebés nascidos entre septiembre de 2002 y mayo de 2003, en la ciudad de Pelotas (RS, Brasil. Se incluyó a 2.741 bebés en las maternidades y una muestra aleatoria de 30%, seguida en el primero y el tercero meses de vida. Se realizaron análisis uni, bi y multivariados, y solamente las variables con pOBJECTIVE: To study the feeding pattern in the first three months of babies born in the Pelotas city, in Sothern Brazil. METHODS: Prospective cohort study, with babies born between september 2002 and may 2003. Among 2,741 babies whose mothers were interviewed at the maternity ward, a random sample of 30% was followed up on the first and third months of age. Univariate, bivariate and multivariate analyses were applied. Variables with a p<0.05 were considered as associated. RESULTS: 951 babies were followed up on the first month, 60% were under exclusive maternal breastfeeding, and 10% were already weaned. Smoking during pregnancy, father's educational level lower than four years and the use of a pacifier were associated to weaning. On the third month, 29% had been weaned, 39% received maternal milk exclusively, and 59% were bottle fed. Smoking during pregnancy, father schooling and the use of a pacifier were associated with weaning. There was an increase in the pacifier use - from 56 to 66% between the first and the third month of

  16. The 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study: methods A visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993: métodos

    Directory of Open Access Journals (Sweden)

    Cora Luiza Araújo

    2010-10-01

    Full Text Available The aim of this study is to describe the methodology of the 2004-2005 follow-up visit of the 1993 Pelotas (Brazil birth cohort. All children born in Pelotas in 1993 and whose mothers lived in the city at that time were eligible to be enrolled in a longitudinal study. Between July 2004 and March 2005, all cohort participants were sought for a follow-up visit. Several strategies were used to help trace cohort members, including a census of the city's schools and a census of all households in the municipality. The Mortality Information System was monitored in order to identify deaths among cohort members. Of the 5,249 cohort members, 4,452 were interviewed in 2004-5. When added to the 141 deaths, these represent 87.5% of the original cohort. In spite of the logistic and financial difficulties, it is possible to carry out prospective studies with long-term follow-up in the Brazilian context.O objetivo deste artigo é descrever a metodologia do acompanhamento realizado em 2004-2005 da coorte de nascidos em 1993 na cidade de Pelotas, Rio Grande do Sul, Brasil. Todas as crianças nascidas em 1993 nessa cidade, cujas mães residiam no município, foram elegíveis para um estudo longitudinal. Entre os meses de julho de 2004 e março de 2005, todos os participantes da coorte foram procurados para um acompanhamento. Diversas estratégias de busca foram utilizadas para auxiliar na localização dos participantes, sendo as principais um censo em todas as escolas do município e um censo domiciliar. O Sistema de Informações sobre Mortalidade foi monitorado para detecção de óbitos de participantes da coorte. Dos 5.249 participantes da coorte, 4.452 foram entrevistados em 2004-2005, os quais, somados aos 141 óbitos detectados, representam 87,5% da coorte original. Apesar das dificuldades logísticas e financeiras, é possível realizar estudos prospectivos com altas taxas de acompanhamento em longo prazo no contexto brasileiro.

  17. Phytosociology of a coastal peat forest of the Toto Beach, Municipality of Pelotas, RS, Brazil

    Directory of Open Access Journals (Sweden)

    Tiago Schuch Lemos Venzke

    2015-06-01

    Full Text Available Floristic composition and structure of the tree component were analyzed in a coastal peat forest of the Toto Beach, located in the southern region of Lagoa dos Patos (31º43’39”S e 52º12’04”W. The phytosociological sampling was conducted on a sample area of 0.1 ha. All trees with DBH ≥ 4.8 cm were included. The species richness found was equivalent to 23 species distributed in 20 genera and 15 families. Two endangered species were sampled. The total tree density estimated for one hectare was equivalent to 3,480 trees. The most important species in the forest structure were Ocotea sp., Myrcia multiflora, Psidium cattleyanum, Ocotea pulchella, Myrsine lorentziana, Citharexyllum myrianthum, Ilex dumosa, Syagrus romanzoffiana, Guapira opposita and Sebastiania brasiliensis. The species diversity estimated by the Shannon index was 2,174 nats.ind.-1 and evenness (J was 0.684. The forest structure, number of taxa and diversity are similar to other surveys carried out in swamp forests of southern and southeastern Brazil. These parameters must be considered in the environmental licensing and ecological restoration projects of this forest type.

  18. Sporothrix schenckii in a hospital and home environment in the city of Pelotas/RS - Brazil

    Directory of Open Access Journals (Sweden)

    Antonella S. Mattei

    2011-12-01

    Full Text Available This study describes the isolation of S. schenckii in hospital and home environments in Brazil. Samples were collected from surfaces of a veterinary service place and at home. S. schenckii was detected in 1.5% of the samples from the hospital environment. However, this fungus was isolated from all sampled areas in home environments. The isolation of S. schenckii deonstrates that these surfaces could act as infection sources to anials and huans. Therefore, employees and pet owners could be exposed to this agent, and the contamination, through surfaces, could occur through the traumatic inoculation of the fungus or by direct contact with pre-existing lesions.Esse estudo descreve o isolamento de S. schenckii em ambiente hospitalar e domiciliar, no Brasil. Foram colhidas amostras de superfície de local de atendimento veterinário e ambiente domiciliar. S. schenckii foi isolado em 1,5% das amostras do ambiente hospitalar. Entretanto, esse fungo foi isolado em todas as amostras do ambiente domiciliar. O isolamento do S. schenckii demonstra a importância dessas superfícies atuarem como fontes de infecção para animais e humanos. Portanto, funcionários e proprietários de animais de estimação estariam expostos a esse agente e a contaminação, através das superfícies, poderia ocorrer pela inoculação traumática do fungo ou pelo contato direto com lesões pré-existentes.

  19. FUNGI ISOLATED FROM THE EXCRETA OF WILD BIRDS IN SCREENING CENTERS IN PELOTAS, RS, BRAZIL

    Directory of Open Access Journals (Sweden)

    Josiara Furtado Mendes

    2014-12-01

    Full Text Available The identification of the fungal species belonging to the healthy microflora in animals is a precondition for the recognition of pathological processes causing them. The aim of this study was to investigate the presence of potentially pathogenic fungi in the feces of wild birds collected in Screening Centers. Samples were collected from the feces of 50 cages with different species of birds. The samples were processed according to the modified method STAIB and the plates incubated at 32 °C for up to ten days with daily observation for detection of fungal growth. The isolation of the following species was observed: Malassezia pachydermatis, Candida albicans, C. famata, C. guilliermondii, C. sphaerica, C. globosa, C. catenulata, C. ciferri, C. intermedia, Cryptococcus laurentii, Trichosporon asahii, Geotrichum klebahnii, Aspergillus spp., A. niger and Penicillium spp. Knowing the character of some opportunistic fungi is important in identifying them, facilitating the adoption of preventive measures, such as proper cleaning of cages, since the accumulation of excreta may indicate a risk for both health professionals and centers for screening public health.

  20. Maria - RS

    Directory of Open Access Journals (Sweden)

    Suzinara Beatriz Soares de Lima

    2005-01-01

    Full Text Available Estudio de carácter histórico social que tiene como objetivo describir la memoria del servicio de enfermaria del Hospital Universitário de Santa Maria, en la Universidade Federal de Santa Maria – RS, durante el periodo de 1459 al 2000. Las fuentes primarias fueron documentos escritos y declaraciones orales de enfermeras que hacieron parte de esta trayectoria, y como fuentes secundarias se utilizaron los artículos y libros sobre el temática. Los resultados demuestran que el hospital, desde su fundación sufrió varias alteraciones en función de su misión y de las condiciones contextuales de trabajo. Fueron muchos los problemas administrativos enfrentados por los profisionales de enfermería. A razón de los hallazgos fue evidente el hecho de que la discusión de la racionalidad asistencial, las condiciones de trabajo y la posible autonomía profesional representan un avance importante para la comprensión del presente y la proyección del futuro servicio de enfermería del Hospital.

  1. Efecto del Cambio de Reglas en Pelota Vasca Escolar

    Directory of Open Access Journals (Sweden)

    Oidui Usabiaga Arruabarrena

    2014-01-01

    Full Text Available El objetivo del presente estudio fue analizar la influencia de las modificaciones de reglas en la acción de juego de los escolares que participaron en un programa de deporte escolar de pelota a mano. La muestra estuvo compuesta por 60 escolares de 8 a 12 años, 35 participaron en seis partidos celebrados durante el curso 2007-08 y los 25 restantes en otros seis enfrentamientos del 2008- 09. El registro se llevó a cabo mediante un instrumento observacional ad hoc y posteriormente se realizó un análisis de las variables: zona y tipo de golpe, ubicación espacial en situación de espera y dirección del saque, resto y juego de intercambio. La comparación (curso 2007-08 y 2008-09 de medias se llevó a cabo mediante el test no paramétrico de U de Mann-Whitney (p < 0,05, con corrección de Bonferroni. Los resultados muestran que, después de modificar las reglas, los jugadores de ambos cursos juegan de forma similar: golpean la pelota con la mano derecha en zonas próximas a la pared frontal e izquierda, se ubican a la derecha del jugador que golpea en los duelos por parejas y a la izquierda en los individuales, dirigen los saques a media distancia, cometen faltas en el resto y juego de intercambio y desarrollan un juego a corta distancia. La única diferencia se encontró en el resto a distancia corta y a la derecha. El análisis de indicadores de juego puede ser de gran ayuda para conocer los efectos de los cambios de reglas en el ámbito formativo.

  2. Campylobacter jejuni occurrence in chicken fecal samples from small properties in Pelotas, southern of Brazil Ocorrência de Campylobacter jejuni em amostras fecais de galinhas em pequenas propriedades de Pelotas, sul do Brasil

    Directory of Open Access Journals (Sweden)

    Fabiane R. Gomes

    2006-09-01

    Full Text Available The aim of this study was to evaluate the occurrence of thermophilic Campylobacter species in broiler flocks from 26 small properties located near the campus of Federal University of Pelotas, RS, Brazil. A total of 404 chicken fecal samples were analyzed and after isolation, identification and biotyping was performed according to Lior´s scheme. Twenty one strains (5.2% of Campylobacter jejuni biotype II were isolated from animals from seven properties (26.9%, with a variation from 3% to 34.6% among the positive properties. We also analyzed twelve C. jejuni isolates by polymerase chain reaction (PCR, using specific primers that generate a fragment of 402 pb. Our study allowed us to observe that chickens raised in non-industrial establishments without sanitary attention can harbour C. jejuni in their intestinal tract, and by doing so, they could be a serious health risk to humans.O objetivo deste estudo foi avaliar a ocorrência de espécies termofílicas de Campylobacter em galinhas de 26 pequenas propriedades localizadas próximo ao campus da Universidade Federal de Pelotas, RS, Brasil. Um total de 404 amostras fecais de galinhas foram analisadas e após o isolamento, a identificação e a biotipificação foram realizadas de acordo com o esquema de Lior. Vinte e uma amostras (5,2% de Campylobacter jejuni biotipo II foram isoladas de animais de sete propriedades (26,9%, com uma variação de 3,3% a 34,6% entre as propriedades positivas. Primers específicos, que geram um fragmento de 402pb, foram usados em PCR para analisar 12 isolados de C. jejuni. Concluímos que galinhas criadas em estabelecimentos não industriais e sem atenção sanitária, são portadoras de C. jejuni e, desta forma, podem ser consideradas um fator de risco para infecção humana.

  3. Mandibular fracture cases in Pelotas, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Rafael Silva da Silva

    2009-10-01

    Full Text Available Objectives: To analyze the data in the literature, which show a high incidence of mandibular fractures. The aim of this research was to elucidate the context in which these fractures occur among patients attended at the first aid center of “Pronto Socorro Municipal de Pelotas”, Rio Grande do Sul, Brazil. Methods: From the records referring to the period of June, 2001 to August, 2007, there were 1 345 patients with facial fractures. Of this total, 116 patients with mandibular fracture were selected for this study and the items analysed were: age, gender, mandibular fracture site, etiology and period of the year. Results: It was found that 86.2% of the sample were men. The most prevalent age was 20 to 29 years old representing 36.2%, and the most affected mandibular sites were the body, with 29 cases (25%, and the condyle, with 26 cases (22.4%. The most common cause of fractures was the physical aggression representing 37.1%. The period of the year with the highest incidence of mandibular fractures was the summer, with 38 cases (32.8%. Conclusion: It was therefore observed that the patients with mandibular fracture assisted at Pronto-Socorro Municipal de Pelotas, Rio Grande do Sul, Brazil, were generally men, 20 to 29 years old with mandibular body fracture and they were victims of physical aggression.

  4. Fundación cultural en el deporte: el caso de la pelota vasca

    Directory of Open Access Journals (Sweden)

    González Abrisketa, Olatz

    2006-12-01

    Full Text Available The author aims to analyze pelota as a framework for concepts of meaning and worldview. Cultural meanings merge at a juncture, bringing about the possibility of change within an otherwise resilient pattern of communion between players and spectators. The author contends that pelota has had a central role in the formation and reproduction of Basques’ collective consciousness —a ritual exercise, nowadays turned into an industrialized sport, that represents an expressive act of cultural founding while transmitting elementary narratives of the bond of identity.

    El presente artículo pretende analizar la pelota vasca en tanto que marco de concepción de sentidos y de representación del mundo. Los significados culturales se refundan dentro de la coyuntura, posibilitando el cambio dentro de la permanencia y la comunión entre jugadores y público. Este artículo defiende que la pelota ha ocupado un papel central en la conformación y mantenimiento de la conciencia colectiva de los vascos, y postula que la pelota es una práctica ritualmente celebrada y convertida hoy en deporte industrializado, que representa un expresivo acto de fundación cultural y que transmite narrativas elementales del vínculo identitario.

  5. Seabed acoustic classification in the Pelotas basin, Brazil

    Directory of Open Access Journals (Sweden)

    Paloma Lumi Costa

    2013-03-01

    Full Text Available The present study sought to develop a seabed map of the region of the Pelotas Basin using acoustic methods. A total number of 1,507,823 seabed reflectivity data, collected during six oceanographic surveys, were processed to generate a seabed map. Data processing consisted of the classification of the acoustic parameter BSBS (Bottom Surface Backscattering Strength obtained with the Scientific Echosounder EK 500 operating at a frequency of 38 kHz. BSBS is expressed in decibels (dB, and corresponds to a logarithm of the ratio between incident acoustic energy and the energy reflected by the seabed. Four BSBS value classes, associated with different sediment types, were established. High BSBS values are associated with coarse sediments, whereas low values indicate fine sediments. A seabed reflectivity map was generated using the Natural Neighbor method to interpolate the BSBS values organized according to the pre-established classes. Four features with high BSBS values were identified at 100-200 m depth. The largest one was found in the region of Santa Marta Cape and attributed mainly to consolidated seabed and/or the presence of biodetritic material, according to comparison with maps available in the literature. Above 500m depth, there was a predominance of acoustically low reflectivity sea floor, which was attributed to the presence of muddy sediment. Considering the lack of information on the seabed at great depths, the acoustic method was shown to be an alternative tool to obtain data on seabed characteristics in these regions.O presente estudo teve como objetivo principal a realização de um mapeamento de fundo, através de metodologia acústica, para a região da Bacia de Pelotas. Um total de 1.507.823 dados de refletividade de fundo provenientes de seis Cruzeiros Oceanográficos foi processado para elaboração de um mapa de refletividade de fundo. Esse processamento consistiu numa classificação dos valores do parâmetro acústico BSBS

  6. Ocorrência de Cryptococcus neoformans em excretas de pombos na cidade de Pelotas, Estado do Rio Grande do Sul Occurrence of Cryptococcus neoformans in pigeon excrement in the city of Pelotas, State of Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Renata Osório de Faria

    2010-04-01

    Full Text Available INTRODUÇÃO: O Cryptococcus neoformans é uma levedura capsulada, agente etiológico da criptococose em humanos e animais, encontrado em fontes ambientais, incluindo excretas de pombos, é uma importante causa de mortalidade em indivíduos imunodeprimidos em todo o mundo. MÉTODOS: Com o objetivo de verificar a ocorrência do Cryptococcus neoformans, em excretas de pombos, na Cidade de Pelotas, pesquisou-se 70 ambientes, incluindo prédios, praças e locais ao ar livre, da Cidade de Pelotas, RS. Após a coleta, os excrementos foram adicionados de salina com cloranfenicol, homogeneizados, semeados em ágar Sabouraud com cloranfenicol e ágar Níger e incubados a 32ºC. Para identificação, realizou-se exame direto, prova da fenoloxidase, urease, assimilação de carboidratos e cultura em meio CGB. RESULTADOS: Dos locais estudados (nº =70, em 26 (37,1% havia excretas de pombos. Estes lugares foram representados por prédios históricos (nº =8, torre de igreja (nº =1, engenhos e armazéns de arroz (nº =7, praça (nº =1 e locais ao ar livre (nº =9, o isolamento de Cryptococcus neoformans ocorreu em 26,9% (nº =7/26, destes locais. CONCLUSÕES: O estudo chama a atenção, para o isolamento do fungo em áreas urbanas, que apresentavam grande acúmulo de excretas, indicando um risco para a saúde pública, especialmente para indivíduos imunocomprometidos.INTRODUCTION: Cryptococcus neoformans is an encapsulated yeast and is the etiological agent for human and animal cryptococcosis. It is found in sources within the environment, including pigeon excrement, and is an important cause of mortality among immunocompromised individuals worldwide. METHODS: Seventy different environments in the city of Pelotas, Rio Grande do Sul, were surveyed for the purpose of investigating Cryptococcus neoformans occurrences in pigeon excreta. The environments included buildings, public squares and outdoor locations in the city. After collection, chloramphenicol

  7. Auditoria Médica: atendimento de crianças com asma em uma Unidade de Saúde da Família, Pelotas, RS Medical Auditing: care to asthmatic children in a Family Health Unit, Pelotas, RS

    Directory of Open Access Journals (Sweden)

    Ana Maria Siga Stephan

    2009-06-01

    Full Text Available Descrição do processo de atendimento médico às crianças com asma, mediante auditoria realizada concomitantemente a estudo transversal, conduzido em crianças da área de cobertura de uma Unidade de Saúde da Família, para verificar a prevalência de asma e avaliar o conhecimento materno sobre a doença. Utilizaram-se como fonte de dados os prontuários de família das crianças com asma que se consultaram nos últimos 12 meses. Das 258 crianças com asma identificadas no estudo, 69 (26,7% tinham registros de consultas devido à doença. Havia registros de peso em 76,8% dos prontuários, de frequência respiratória em 26,1%, de tiragem intercostal em 21,7%, de cianose em 1,4% e de orientações sobre o uso da medicação em 33,3%. A frequência de registros de orientações sobre os sinais e sintomas de gravidade e o manejo das crises foi de 15,9% e sobre os fatores desencadeantes, modificações ambientais e comportamentais, 14,5%. Foram encontrados registros de prescrição de broncodilatador para 55,1% das crianças, e de corticoesteroide mais broncodilatador para 42,0%. Os baixos percentuais de registros sobre orientações evidenciam as deficiências no atendimento médico realizado na Unidade de Saúde da Família, sobretudo no que se refere à educação em saúde.This is a description of the process of medical care to children with asthma, through an audit carried out concomitantly with a cross-sectional study with children living in the catchment area of a Family Health Unit, to find the prevalence of asthma and to assess maternal knowledge about the disease. Medical records of families whose children had asthma and visited doctors in the previous 12 months were used as sources of data. Of the 258 children identified with asthma, 69 (26.7% had visited the unit because of the disease. Weight was recorded in 76.8% of the medical records, respiratory frequency in 26.1%, intercostal retractions in 21.7%, cyanosis in 1.4%, and orientations on the use of medication in 33.3%. Orientations on the signs and symptoms of severity and crisis management were recorded in 15.9% of the charts and trigger factors, environmental changes, and behavior were recorded in 14.5% of them. There were records of prescription of bronchodilators for 55.1% of the children and of bronchodilator plus corticosteroid for 42.0% of them. The low percentage of records of orientation is an evidence of the deficiencies of medical care in Family Health Units, especially regarding education in health.

  8. Macroinvertebrados bentônicos como indicadores de qualidade de água na Barragem Santa Bárbara, Pelotas, RS, Brasil Zoobenthics as indicators of the water quality in the Santa Bárbara Dam, Pelotas, RS, Brazil

    Directory of Open Access Journals (Sweden)

    Sérgio Renato Noguez Piedras

    2006-04-01

    Full Text Available O objetivo deste trabalho foi estudar o impacto de dois afluentes da barragem Santa Bárbara sobre o ambiente da mesma, utilizando a ocorrência de invertebrados bentônicos e características químicas da água. Durante nove meses foram realizadas coletas e análises da água e de invertebrados bentônicos nos afluentes Sanga da Barbuda e Sanga do Passo do Cunha e também no interior da bacia de acumulação da barragem. Os resultados mostram que, embora a Sanga da Barbuda e a Sanga do Passo do Cunha apresentem características químicas abaixo do recomendável, no limite aceitável pela legislação que determina os padrões de qualidade da água para abastecimento público, estes afluentes estão, ainda, sendo diluídos de forma satisfatória na bacia de acumulação da barragem. O estudo das relações entre variáveis químicas e invertebrados bentônicos mostra haver correlação significativa entre os baixos níveis de oxigênio dissolvido e a presença de Oligochaeta, sendo que o aumento do número de Oligochaeta indica uma situação de anoxia na barragem Santa Bárbara.The objective of this work was to study the impact of two tributaries from the Santa Bárbara Dam on this environment using the occurrence of zoobenthics and some water chemical characteristics. Monthly gathering and analysis from the water and zoobenthics were done during nine months in the tributaries Sanga da Barbuda and Sanga Passo do Cunha as well as in the inner part of the accumulation basin in the Santa Barbara dam. The results demonstrate that, though Sanga da Barbuda and Sanga Passo do Cunha present chemical characteristics lower than the recommended but still in the limits acceptable by the law that regulates the water quality standards for the supply, these tributaries are being diluted in a satisfactory way in the accumulation basin in the Santa Barbara dam. The study of the relations between chemical variables and zoobenthics show a significant correlation between low levels of dissolved oxygen and the presence of Oligochaeta; moreover, the increase of Oligochaeta indicates a situation of anoxia in the Santa Barbara Dam.

  9. Jugadores de pelota maya en tiempos del oxlajuj b’ak’tún

    Directory of Open Access Journals (Sweden)

    Jairzinho Francisco Panqueba Cifuentes

    2012-12-01

    Full Text Available La presente reflexión hace parte de un proceso investigativo cuyo objeto ha sido la práctica contemporánea del juego de pelota maya en Guatemala. Es un acercamiento analítico a los testimonios de vida recabados a través de la metodología de investigación-aprehendizaje compartida con los actores del proceso. Sus trayectorias vitales nos permiten comprender en descripciones y acciones, los detalles contemporáneos de una manifestación cultural, lúdica y recreativa ancestral. Pero también de qué maneras el juego de pelota mesoamericano es fuente de conocimientos de los patrimonios corporales hasta ahora difusos entre discursos relacionados con el folclor, las etnicidades, las artes, el deporte, la cultura, las espiritualidades y en general con ciencias como la historia, la antropología y la arqueología. Las vidas cotidianas de los actuales jugadores de pelota ayudan a comprender una parte de las sabidurías ancestrales mayas. Se integran, por tanto, a los testimonios de las herencias inmateriales arqueológicas representadas en los campos de juego de pelota diseminados por Mesoamérica.

  10. Entre amores invisíveis e silenciados : histórias de abusadoras sexuais na cidade de Pelotas (RS)

    OpenAIRE

    SCOBERNATTI, Gisele

    2011-01-01

    A análise das motivações femininas que levam ao cometimento do abuso sexual constitui o foco central deste trabalho, tendo como pano de fundo os elementos sóciohistóricos e culturais que pudessem estar presentes na construção das subjetividades de homens e mulheres que abusam sexualmente. Para tal empreendimento, utilizou-se como recursos metodológicos, a história oral de vida e temática, bem como a análise documental de procedimentos formais, porquanto o abuso sexual de crianças e adolescent...

  11. Characterization of Listeria monocytogenes isolated from a fresh mixed sausage processing line in Pelotas-RS by PFGE

    Science.gov (United States)

    von Laer, Ana Eucares; de Lima, Andréia Saldanha; Trindade, Paula dos Santos; Andriguetto, Cristiano; Destro, Maria Teresa; da Silva, Wladimir Padilha

    2009-01-01

    Listeria monocytogenes is a bacterium capable to adhere to the surfaces of equipment and utensils and subsequently form biofilms. It can to persist in the food processing environmental for extended periods of time being able to contaminate the final product. The aim of this study was to trace the contamination route of L. monocytogenes on a fresh mixed sausage processing line, from raw material to the final product. The isolates obtained were characterized by serotyping and molecular typing by pulsed-field gel electrophoresis (PFGE) using the restriction enzymes ApaI and AscI. L. monocytogenes was detected in 25% of the samples. The samples of raw material were not contaminated, however, the microorganism was detected in 21% of the environmental samples (food contact and non-food contact), 20.8% of the equipments, 20% of the food worker’s hands, 40% of the mass ready to packaging and in all the final products samples, demonstrating that the contamination of final product occurred during the processing and the importance of cross contamination. PFGE yielded 22 pulsotypes wich formed 7 clusters, and serotyping yielded 3 serotypes and 1 serogroup, however, the presence of serotypes 4b and 1/2b in the final product is of great concern for public health. The tracing of contamination showed that some strains are adapted and persisted in the processing environment in this industry. PMID:24031402

  12. Óbitos evitáveis até 48 meses de idade entre as crianças da Coorte de Nascimentos de Pelotas de 2004

    Directory of Open Access Journals (Sweden)

    Luis Ramon Marques da Rocha Gorgot

    2011-04-01

    Full Text Available OBJETIVO: Descrever óbitos evitáveis de crianças pertencentes à Coorte de Pelotas, RS, de 2004. MÉTODOS: O óbito de 92 crianças entre 2004-2008 da Coorte de Pelotas 2004 foi identificado e classificado conforme a Lista de Causas de Mortes Evitáveis por Intervenções do Sistema Único de Saúde. Os Sistemas de Informação sobre Mortalidade (SIM municipal e estadual foram rastreados para localizar mortes ocorridas fora de Pelotas e as causas após o primeiro ano vida. O óbito de menores de um ano foi avaliado e comparado entre um subestudo e o SIM. Foram calculados coeficientes de mortalidade: 1.000 nascidos vivos (NV, mortalidade proporcional por causas evitáveis e conforme tipo de unidade básica de saúde (tradicional ou Estratégia Saúde da Família. RESULTADOS: O coeficiente de mortalidade foi de 22,2:1.000 NV, 82 óbitos ocorreram no primeiro ano de vida (19,4:1.000 NV, dos quais 37 (45% na primeira semana. Mais de ¾ dos óbitos (70/92 eram evitáveis. No primeiro ano de vida, a maioria (42/82 das mortes seriam evitadas pela adequada atenção à mulher durante a gestação; de acordo com o SIM, a maioria (n = 32/82, pela adequada atenção ao recém-nascido. Não houve diferença entre o tipo de Unidade Básica de Saúde quanto à proporção de óbitos evitáveis. CONCLUSÕES: É alta a proporção de óbitos infantis que podem ser evitados. Para que os óbitos evitáveis possam ser utilizados como indicadores no monitoramento da qualidade da atenção à saúde materno-infantil, é necessário aprimorar a qualidade dos os registros das Declarações de Óbito.

  13. Incentivo à leitura nas bibliotecas escolares da rede pública municipal de Pelotas e a inexistência de políticas públicas sistematizadas (1987-2003

    Directory of Open Access Journals (Sweden)

    Renata Braz Gonçalves

    2007-04-01

    Full Text Available A pesquisa buscou investigar a existência de uma política sistematizada de incentivo à leitura na rede pública municipal de ensino de Pelotas/RS, entre os anos de 1987 e 2003. A metodologia utilizada abarcou a revisão bibliográfica e a pesquisa documental, tendo como fontes documentos pertencentes aos arquivos inativos da Secretaria Municipal de Educação de Pelotas. Constatou-se que, nesse período, não houve uma política sistematizada de incentivo à leitura por parte do governo municipal e que mínimos foram os reflexos dos programas nacionais de incentivo à leitura na rede de ensino estudada. No entanto, verificou-se a preocupação e a insistência de muitos professores, principalmente aqueles que atuavam em bibliotecas das escolas municipais, em promover o incentivo à leitura. Dessa forma, este artigo mostra que dificuldades foram enfrentadas e que estratégias foram utilizadas por esses professores para amenizar tais limitações.

  14. Óbitos evitáveis até 48 meses de idade entre as crianças da Coorte de Nascimentos de Pelotas de 2004 Óbitos evitables hasta los 48 meses de edad entre los niños de La Cohorte de Nacimientos de Pelotas de 2004 Avoidable deaths until months of age among children from the 2004 Pelotas birth cohort

    Directory of Open Access Journals (Sweden)

    Luis Ramon Marques da Rocha Gorgot

    2011-04-01

    Full Text Available OBJETIVO: Descrever óbitos evitáveis de crianças pertencentes à Coorte de Pelotas, RS, de 2004. MÉTODOS: O óbito de 92 crianças entre 2004-2008 da Coorte de Pelotas 2004 foi identificado e classificado conforme a Lista de Causas de Mortes Evitáveis por Intervenções do Sistema Único de Saúde. Os Sistemas de Informação sobre Mortalidade (SIM municipal e estadual foram rastreados para localizar mortes ocorridas fora de Pelotas e as causas após o primeiro ano vida. O óbito de menores de um ano foi avaliado e comparado entre um subestudo e o SIM. Foram calculados coeficientes de mortalidade: 1.000 nascidos vivos (NV, mortalidade proporcional por causas evitáveis e conforme tipo de unidade básica de saúde (tradicional ou Estratégia Saúde da Família. RESULTADOS: O coeficiente de mortalidade foi de 22,2:1.000 NV, 82 óbitos ocorreram no primeiro ano de vida (19,4:1.000 NV, dos quais 37 (45% na primeira semana. Mais de ¾ dos óbitos (70/92 eram evitáveis. No primeiro ano de vida, a maioria (42/82 das mortes seriam evitadas pela adequada atenção à mulher durante a gestação; de acordo com o SIM, a maioria (n = 32/82, pela adequada atenção ao recém-nascido. Não houve diferença entre o tipo de Unidade Básica de Saúde quanto à proporção de óbitos evitáveis. CONCLUSÕES: É alta a proporção de óbitos infantis que podem ser evitados. Para que os óbitos evitáveis possam ser utilizados como indicadores no monitoramento da qualidade da atenção à saúde materno-infantil, é necessário aprimorar a qualidade dos os registros das Declarações de Óbito.OBJETIVO: Describir óbitos evitables de niños pertenecientes a la Cohorte de Pelotas, Sur de Brasil, de 2004. MÉTODOS: Los óbitos de 92 niños entre 2004-2008 de la Cohorte de Pelotas 2004 fueron identificados y clasificados conforme la Lista de Causas de Muertes Evitables por Intervenciones del Sistema Único de Salud de Brasil. Los sistemas de información sobre

  15. RS-WebPredictor

    DEFF Research Database (Denmark)

    Zaretzki, J.; Bergeron, C.; Huang, T.-W.;

    2013-01-01

    . RS-WebPredictor is the first freely accessible server that predicts the regioselectivity of the last six isozymes. Server execution time is fast, taking on average 2s to encode a submitted molecule and 1s to apply a given model, allowing for high-throughput use in lead optimization projects...

  16. “Trabalhadores, Maçonaria e Espiritismo em Pelotas: 1877-1937”

    Directory of Open Access Journals (Sweden)

    Marcelo Freitas Gil

    2011-01-01

    Full Text Available This paper deals with the relationship between Freemasonry, Spiritualism, and urban workers in Pelotas, Rio Grande do Sul, Brazil, in 1877 when the spiritual doctrine was introduced in the city by two professionals in Spain. In 1937, when, according to the installation of the Estado Novo in Brazil, the dictatorial regime implemented by President Getulio Vargas, began to restrict Spiritualism and Freemasonry in Pelotas. The regime even started to use force, since Masons were suspected of harboring Communist meetings and of being opponents of the system deployed by Vargas. Based on a literature review, we analyzed this relationship, trying to understand the role played by both Freemasonry and Spiritualism, along with the urban workers of that historical period.

  17. [MaRS Project

    Science.gov (United States)

    Aruljothi, Arunvenkatesh

    2016-01-01

    The Space Exploration Division of the Safety and Mission Assurances Directorate is responsible for reducing the risk to Human Space Flight Programs by providing system safety, reliability, and risk analysis. The Risk & Reliability Analysis branch plays a part in this by utilizing Probabilistic Risk Assessment (PRA) and Reliability and Maintainability (R&M) tools to identify possible types of failure and effective solutions. A continuous effort of this branch is MaRS, or Mass and Reliability System, a tool that was the focus of this internship. Future long duration space missions will have to find a balance between the mass and reliability of their spare parts. They will be unable take spares of everything and will have to determine what is most likely to require maintenance and spares. Currently there is no database that combines mass and reliability data of low level space-grade components. MaRS aims to be the first database to do this. The data in MaRS will be based on the hardware flown on the International Space Stations (ISS). The components on the ISS have a long history and are well documented, making them the perfect source. Currently, MaRS is a functioning excel workbook database; the backend is complete and only requires optimization. MaRS has been populated with all the assemblies and their components that are used on the ISS; the failures of these components are updated regularly. This project was a continuation on the efforts of previous intern groups. Once complete, R&M engineers working on future space flight missions will be able to quickly access failure and mass data on assemblies and components, allowing them to make important decisions and tradeoffs.

  18. Anencefalia: um estudo epidemiológico de treze anos na cidade de Pelotas Anencephaly: thirteen years of epidemiological study in Pelotas city

    Directory of Open Access Journals (Sweden)

    Ricardo Ramires Fernández

    2005-03-01

    Full Text Available A anencefalia é a forma letal mais comum dentre as anomalias do SNC. Apesar dos casos isolados, a anencefalia parece ser de causa multifatorial. Este defeito ocorre devido a um não fechamento da extremidade anterior do sulco neural. Este trabalho, que tem como objetivo estudar a freqüência, a etiologia e os fatores predisponentes desta malformação, é um estudo de caso-controle de base populacional que abrange todos os nascimentos ocorridos nas cinco maternidades da cidade de Pelotas, durante o período de 1º de janeiro de 1990 a 31 de dezembro de 2002.The anencephaly is the most common lethal form among the CNS anomalies. Although isolated cases occur, the anencephaly seems to be caused by multiple factors. This malformation result from closure defects of the anterior neural sulk, during embryonic development. The aim of this study was analyze the frequency, etiology, and the risk factors of this congenital malformation. This population-based case-control study range all births occurred in five maternities of Pelotas city from January, 1st 1990 to December, 12 2002.

  19. Biochronostratigraphy of the Pelotas Basin: Actual state and application in the petroleum geology; Biocronoestratigrafia da Bacia de Pelotas: estado atual e aplicacao na geologia do petroleo

    Energy Technology Data Exchange (ETDEWEB)

    Anjos-Zerfass, Geise de Santana dos; Souza, Paulo Alves de; Chemale Junior, Farid [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Inst. de Geociencias]. E-mails: geise.anjos@ufrgs.br; paulo.alves.souza@ufrgs.br, farid.chemale@ufrgs.br

    2008-07-01

    The bio stratigraphic studies of the Brazilian sedimentary basins have providing a support for the exploratory research of energetic and mineral resources, in particular at the continental margin. From new discoveries of hydrocarbon accumulations at the Santos and Campos basins, the south portion of the Brazilian continental margin were converted in an important target of the exploration. Therefore, the bio stratigraphic refinement is necessary to detect gaps and to promote an increment on the precision of the lateral correlations in the delimitation and spatial analysis of the potential reservoirs. The actual stage of the bio-chronostratigraphic framework of the Pelotas Basin is presented herein, focusing on its application to the reservoir prospection. The main questions and lacunae on the knowledge are also discussed. In terms of bio stratigraphy, the Pelotas Basin remains poorly evaluated, despite publication of important works on the bio stratigraphy are known since the 1960's. A comparison of bio stratigraphic schemes proposed for the Tertiary section of the basin allows the inference of diverse hiatuses, identified by the absences of bio zones. Hiatuses identified in the {sup 87}Sr/{sup 86}Sr curve, suggest their relationship with discontinuities in the deposition. Discrepancies between the proposed schemes can be attributed to the particular resolution of the different groups used, the variations in the bio stratigraphic criteria and the sampling interval, influencing the bio stratigraphic resolution and therefore its potential as a correlation tool. (author)

  20. Trails, RS2477, RS2477, Published in 2005, Daggett County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2005. It is described as 'RS2477'. Data by this publisher are often provided...

  1. RS-232 Led Board

    CERN Document Server

    Tskhvaradze, Vladimir

    2007-01-01

    This article demonstrates how to develop a Microchip PIC16F84 based device that supports RS-232 interface with PC. Circuit (LED Board) design and software development will be discussed. PicBasic Pro Compiler from microEngineering Labs, Inc. is used for PIC programming. Development of LED Board Control Console using C/C++ is also briefly discussed. The project requires basic work experience with Microchip PICs, serial communication and programming.

  2. RS-predictor

    DEFF Research Database (Denmark)

    Zaretzki, Jed; Bergeron, Charles; Rydberg, Patrik

    2011-01-01

    This article describes RegioSelectivity-Predictor (RS-Predictor), a new in silico method for generating predictive models of P450-mediated metabolism for drug-like compounds. Within this method, potential sites of metabolism (SOMs) are represented as "metabolophores": A concept that describes...... vector that encodes regioselectivity trends across all cases in a training set. The resulting pathway-independent (O-dealkylation vs N-oxidation vs Csp(3) hydroxylation, etc.), isozyme-specific regioselectivity model may be used to predict potential metabolic liabilities. In the present work, cross...

  3. Monitoramento da ação genotóxica em trabalhadores de sapatarias através do teste de micronúcleos, Pelotas, Rio Grande do Sul Monitoring the genotoxic action in shoe workers by micronucleus test, Pelotas, Rio Grande do Sul State

    Directory of Open Access Journals (Sweden)

    Natália Silveira Corrêa

    2009-12-01

    Full Text Available Neste trabalho, investigou-se a frequência de micronúcleos em células esfoliadas da mucosa bucal de trabalhadores de sapatarias, na cidade de Pelotas (RS. O estudo constou de 54 trabalhadores de sapatarias expostos à cola e solventes e 54 controles. Avaliou-se a incidência de células com micronúcleos(CMN, binucleadas(CBN, núcleos ligados(CNL e total de anomalias(TA, em 2.000 células por indivíduo. Elaborou-se um banco de dados no programa SPSS "for Windows" pelo teste de Mann-Whitney U, pIn this paper it was investigated the micronuclei frequency in exfoliated oral mucosa cells in shoe shop workers in the city of Pelotas, RS. The study counted on 54 shoe workers exposed to glue and solvents and 54 controls. It was evaluated the incidence of cells with micronucleus (CMN, bi-nucleus (CBN, linked nucleus (CLN and total amount of anomalies (TAA, in 2000 cells per person. A database was created in the SPSS "for Windows" software using the Mann-Whitney U, p<0.05 test. The average of anomalies among shoe workers was 8.69±6.49CMN; 8.85±4.92CBN; 5.78±4.78CNL; 23.31±10.01TA, in the controlled 4.00±5.05CMN; 4.63±4.35CBN; 4.76±5.00CNL; 13.39±9.43TA (p=0.0001; p=0.0001; p=0.144 and p=0.0001 respectively. It was also evaluated the age, gender, time of work, family income, smoke, alcohol beverages, the influence of dermatological, ophthalmological, respiratory and central nervous system (CNS diseases in the number of cell anomalies. These items did not have any influence. It was only observed that among the age group of 15 to 29 years old the number of CNL was bigger than among the age group of 45 to 72. Among those with time of work of 0.1 and 10 years presented a higher CNM than in the other group range.

  4. Stagnating influenza vaccine coverage rates among high-risk groups in Poland and Sweden in 2003/4 and 2004/5.

    NARCIS (Netherlands)

    Kroneman, M.W.; Essen, G.A. van

    2007-01-01

    This paper examines influenza vaccine coverage rates (VCR) in Poland and Sweden during the 2003/4 and 2004/5 influenza seasons. An average sample of 2,500 persons was interviewed in each country and each season. Questions regarded age and possible chronic diseases, as well as information on whether

  5. Replacement of HA-MRSA by CA-MRSA infections at an academic medical center in the midwestern United States, 2004-5 to 2008.

    Directory of Open Access Journals (Sweden)

    Michael Z David

    Full Text Available We noted anecdotally that infections designated as health care-associated (HA- MRSA by epidemiologic criteria seemed to be decreasing in incidence at the University of Chicago Medical Center (UCMC after 2004. We compared MRSA patients seen at any site of clinical care at UCMC and the isolates that caused their infections in 2004-5 (n = 545 with those in 2008 (n = 135. The percent of patients with MRSA infections cultured > 2 days after hospital admission decreased from 19.5% in 2004-5 to 7.4% in 2008 (p = 0.001. The percent in 2004-5 compared with 2008 who had a hospitalization (49.1% to 26.7%, p = 0.001 or surgery (43.0% to 14.1%, p<0.001 in the previous year decreased. In 2008 a greater percent of patients was seen in the emergency department (23.1% vs. 39.3% and a smaller percent both in intensive care units (15.6% vs. 6.7% and in other inpatient units (40.7% vs. 32.6% (p<0.001. The percent of patients with CA-MRSA infections by the CDC epidemiologic criteria increased from 36.5% in 2004-5 to 62.2% in 2008 (p<0.001. The percent of MRSA isolates sharing genetic characteristics of USA100 decreased from 27.9% (152/545 to 12.6% (17/135, while the percent with CA-MRSA (USA300 characteristics increased from 53.2% (290/545 to 66.7% (90/135. The percent of infections that were invasive did not change significantly. Our data suggest that HA-MRSA infections, both by epidemiologic and microbiologic criteria, relative to CA-MRSA, decreased between 2004-5 and 2008 at UCMC.

  6. Lifetime overweight and obesity and body composition in adulthood: the 1982 Pelotas (Brazil) birth cohort study.

    Science.gov (United States)

    Callo, Gabriela; Gigante, Denise Pretucci; Barros, Fernando C; Horta, Bernardo Lessa

    2016-01-01

    This study aimed to assess the association between overweight/obesity at different moments in the life cycle and body composition in early adulthood. Data were used from the 1982 Pelotas (Brazil) birth cohort study, which has followed live born children of families residing in the urban area of Pelotas at different ages. At 30 years of age, 3,701 cohort members were interviewed and body composition was assessed using Bod Pod, 2,219 cohort members had at least one weight and height measurement taken in the three periods (childhood, adolescence, and adulthood), 24% never presented overweight, and 68.6% were never classified as obese. Elevated body mass index (BMI) and percent body fat at 30 years of age were associated with individuals classified as overweight in all three periods or in adolescence and adulthood, while those with overweight/obesity only in childhood or adolescence showed mean BMI and percent body fat similar to those who had never presented overweight/obesity. The results indicate the benefit of early interruption of overweight/obesity.

  7. The Pelotas birth cohort study, Rio Grande do Sul, Brazil, 1982-2001

    Directory of Open Access Journals (Sweden)

    Victora Cesar G.

    2003-01-01

    Full Text Available Given the growing recognition of the importance of the life course approach for the determination of chronic diseases, birth cohort studies are becoming increasingly important. This paper describes the methods used in the 1982 Pelotas (Brazil birth cohort study, one of the largest and longest studies of this type in developing countries. All 5,914 hospital births occurring in Pelotas in 1982 (over 99% of all deliveries were studied prospectively. The main stages of the study took place in 1983, 1984, 1986, 1995, 1997, 2000, and 2001. More than two thousand variables are available for each subject who participated in all stages of the study. Recent phases of the study included the examination of 2,250 males when presenting for the army recruitment exam in 2000, the study of a 27% sample of men and women in 2001 through household visits, and the study of over 400 children born to the cohort women. Follow-up rates in the recent stages of the cohort were 78.9% for the army examination and 69.0% for the household visits. Ethnographic and oral health studies were conducted in sub-samples. Some recent results on blood pressure, adolescent pregnancy, and asthma are presented as examples of utilization of the data. Suggestions on lessons learned for other cohort studies are proposed.

  8. The Pelotas Birth Cohort Study, Rio Grande do Sul, Brazil, 1982-2001

    Science.gov (United States)

    2010-01-01

    Given the growing recognition of the importance of the life course approach for the determination of chronic diseases, birth cohort studies are becoming increasingly important. This paper describes the methods used in the 1982 Pelotas (Brazil) birth cohort study, one of the largest and longest studies of this type in developing countries. All 5,914 hospital births occurring in Pelotas in 1982 (over 99% of all deliveries) were studied prospectively. The main stages of the study took place in 1983, 1984, 1986, 1995, 1997, 2000, and 2001. More than two thousand variables are available for each subject who participated in all stages of the study. Recent phases of the study included the examination of 2,250 males when presenting for the army recruitment exam in 2000, the study of a 27% sample of men and women in 2001 through household visits, and the study of over 400 children born to the cohort women. Follow-up rates in the recent stages of the cohort were 78.9% for the army examination and 69.0% for the household visits. Ethnographic and oral health studies were conducted in sub-samples. Some recent results on blood pressure, adolescent pregnancy, and asthma are presented as examples of utilization of the data. Suggestions on lessons learned for other cohort studies are proposed. PMID:14666206

  9. THE ISSUE OF PELOTAS' SLUMS BETWEEN THE 19TH AND 20TH CENTURIES

    Directory of Open Access Journals (Sweden)

    Letícia Nörnberg Maciel

    2014-10-01

    Full Text Available The following paper talks about the formation, urban expansion and the emergence of 19th and early 20th century slums at Pelotas city, Rio Grande do Sul state. Since the rise of this kind of residential building, during the second half of the 19th century up to, at least, the 1920s – the last decade covered by this research – government and local elites had been putting a great effort in order to move away these residences towards the outskirts of the city. All of this ideas were paved around hygienist ideals. Lots and edifications in downtown Pelotas had an increase in economic value because of the expansion of that area. That being said, it was important to force a migration of these slums, away from central areas, based upon aesthetic reasons and in order to increase even more the value of the area.

  10. Uso estratégico del espacio en categorías de formación de pelota vasca. [Strategic use of space in basque pelota training categories].

    Directory of Open Access Journals (Sweden)

    Oidui Usabiaga

    2014-04-01

    Full Text Available La pelota vasca es un deporte de pelota compuesto por varias especialidades. La pelota a mano es una de las más practicadas y se juega tanto en duelos individuales como por equipos. El presente estudio pretende analizar y comparar algunos indicadores de juego del uso estratégico del espacio por parte de jugadores benjamines (8-10 años y alevines (10-12 años que participan en un programa de deporte escolar. La muestra estuvo compuesta por doce partidos, seis de benjamines (30 participantes y seis de alevines (30 participantes. El registro se llevó a cabo mediante un instrumento observacional ad hoc diseñado para analizar el uso estratégico del espacio por parte de los participantes, tanto cuando golpean la pelota como cuando están en situación de espera. Los resultados muestran que los participantes de las dos categorías usan el espacio de la misma forma respecto a las zonas de golpe, la ubicación espacial en situación de espera durante los duelos por parejas y los tipos de saque. Los alevines, en comparación a los benjamines, se posicionan más a la derecha del jugador que golpea durante los duelos individuales, dirigen la pelota a distancias medias y cometen menos faltas tanto en el resto del saque como en el juego de intercambio, dando mayor continuidad al juego (p Abstract The basque pelota is a ball sport composed of various specialties. The hand pelota is one of the most popular and is played in both individual and team matchups. The aim of this study was to analyze and compare some indicators of the strategic use of space by young players, 8-10- and 10-12-year-old students, participating in a school sport program. The sample consisted of twelve games, six for each level (30 participants for each level. Data were recorded with an ad hoc observational instrument designed to analyze the strategic use of space by the participants, both when they hit the ball and when they are on standby. The results show that the participants of

  11. Paula, RS, Brasil

    Directory of Open Access Journals (Sweden)

    Solon Jonas Longhi

    2006-01-01

    Full Text Available The present work is part of studies and researches developed at Long Duration Ecological Project - PELD/CNPq, located in São Francisco de Paula’s National Forest (FLONA, RS. The objective of this paper was to identify and to characterize the different stages of succession in mixed rainy forest remains. The work had been accomplished in ten permanent conglomerates of 100m x 100m (10.000m2, which were divided into ten strips of 10m x 100m (1.000m2 and these ones subdivided into ten subunits of 10m x 10m (100m2. In this research, a strip of 10m x 100m was selected for each conglomerate, totaling 100 subunits (stands, where it had been installed, at DBH height, dendrometric bands in all trees with CBH ≥ 30cm, for annual diameters measurement. The cluster analysis was accomplished through the Twinspan program, using a data matrix with ninety-nine stands (one of those was unconsidered by the absence of individuals with CBH ≥ 30cm having as variable the annual increment in diameter (obtained in two years of observations of sixty nine species. Three floristic groups was obtained, indicating stages of succession in the forest: a group separated a less developed stage of succession denominated secondary forest, being Nectandra megapotamica and Cryptocaria aschersoniana the indicative species; a second group indicated an intermediate stage of succession in the forest, being Sebastiania commersoniana and Ocotea pulchella the indicative species; and a third group of primary forest, whose indicative species was Araucaria angustifolia.

  12. Sustentabilidade do fazer artístico-cultural na cidade de Pelotas

    Directory of Open Access Journals (Sweden)

    Maria Stael

    Full Text Available Nos quase dois séculos de existência da cidade de Pelotas, sua tradição cultural tem sido reconhecida em todos os recantos do Rio Grande do Sul e, mesmo, em âmbito nacional. Mas, há muito, trabalhar com arte tem sido um processo cheio de reveses, pois envolve a produção de bens intangíveis e o fato de que consumir tais bens não implica sua posse. Quando isso ocorre, esses produtos nem sempre seguem a lógica capitalista do mercado de consumo - o qual busca vender mais quantidade do que qualidade - e a tendência é a de que não se consiga sustentar sua produção e distribuição.

  13. Thermal behavior of resistant starches RS 2, RS 3, and RS 4.

    Science.gov (United States)

    Ratnayake, W S; Jackson, D S

    2008-06-01

    The thermal behaviors of 3 resistant starch types-RS 2, RS 3, and RS 4-were investigated. Samples were heated in excess water to specific temperatures, from 35 to 85 degrees C at 5 degrees C intervals, and freeze-dried. The treated samples were analyzed using SEM, DSC, XRD, and HPSEC to determine the structural changes at granular and molecular levels. Light microscopy was used to determine real-time thermal behavior of the starches. Although the resistant starches did not show significant morphological changes, as revealed by microscopy, they underwent internal structural changes at low temperatures before complete phase transitions occurred. The structural changes were less in RS 2 compared to the other 2 starches studied. The nongranular material of RS 3's crystallinity decreased gradually from 35 to 85 degrees C and showed microscopically visible changes at >80 degrees C. Cross-linking might have prevented RS 4 from becoming completely amorphous within the temperature range (35 to 85 degrees C) tested. The study indicated that the extent of structural changes depended on the treatment temperature and RS type.

  14. An ISA RS232-RS422/RS485 Converters Card with Optical Isolation%基于ISA总线的RS232/RS485(RS422)通讯转换卡

    Institute of Scientific and Technical Information of China (English)

    陆熊; 周杏鹏

    2003-01-01

    本文针对ISA总线标准,设计了一种带光电隔离的RS232转换卡,它既能实现RS232至RS485的转换,又能实现RS232至RS422的转换,较好地实现了工业控制现场远程数据传输功能.

  15. Interleukin-6-receptor polymorphisms rs12083537, rs2228145, and rs4329505 as predictors of response to tocilizumab in rheumatoid arthritis

    DEFF Research Database (Denmark)

    Enevold, Christian; Baslund, Bo; Linde, Louise;

    2014-01-01

    Tocilizumab (TCZ), a monoclonal antibody targeting the human interleukin-6-receptor (IL-6R), is indicated for the treatment of rheumatoid arthritis (RA). We examined whether three IL6R single-nucleotide polymorphisms rs12083537, rs2228145 (formerly rs8192284), and rs4329505 with previously reported...

  16. RELATÓRIO DO PROJETO DE PESQUISA: "AVENDANO JÚNIOR:ATRADIÇÃO DO CHORO EM PELOTAS"

    Directory of Open Access Journals (Sweden)

    Ana Silveira

    2012-09-01

    Full Text Available O projeto de pesquisa "Avendano Júnior: A Tradição do Choro em Pelotas"é desenvolvido sob a coordenação do Prof. Ms. Raul Costa d'Avila 88 , do Conservatório de Música da Universidade Federal de Pelotas, que percebendo a dimensão interdisciplinar do mesmo, decide realizá-lo em parceria com oLaboratório de Ensino e Pesquisa em Antropologia e Arqueologia (LEPAARQ -UFPel. Trata-se de um projeto que envolve três áreas de conhecimento, Música, Antropologia e História, tendo como foco de análise central a figura do compositor e cavaquinista Joaquim Assumpção Avendano Júnior, bem como o Grupo Musical que o acompanha, o Regional.

  17. COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study

    OpenAIRE

    Angélica Salatino-Oliveira; Joseph Murray; Christian Kieling; Júlia Pasqualini Genro; Guilherme Polanczyk; Luciana Anselmi; Fernando Wehrmeister; Barros, Fernando C; Ana Maria Baptista Menezes; Luis Augusto Rohde; Mara Helena Hutz

    2016-01-01

    Conduct problems in childhood and adolescence are significant precursors of crime and violence in young adulthood. The purpose of the current study is to test the interaction between prenatal maternal smoking and COMT Val 158 Met in conduct problems and crime in the 1993 Pelotas Birth Cohort Study. Conduct problems were assessed through the parent version of the Strengths and Difficulties Questionnaire at ages 11 and 15 years. A translated version of a confidential self-report questionnaire w...

  18. Profibus-DP与RS232/RS422/RS485之间通信适配器的研制%The Development of Communication Adapter Between Profibus-DP and RS232/RS422/RS485

    Institute of Scientific and Technical Information of China (English)

    晁武杰; 甘永梅; 王兆安

    2008-01-01

    详细介绍了基于单片机和SPC3的Profibus-DP与RS232/RS422/RS485之间通信适配器的研制,并给出了详细的硬件电路和软件设计流程.实验表明该通讯适配器对主站和RS232/RS422/RS485接口设备具有数据传输功能,为系统开放互连和现场分布式控制打下基础.

  19. rs- og kapitalmarkedsret

    DEFF Research Database (Denmark)

    Werlauff, Erik; Schaumburg-Müller, Peer

    Bogen giver et samlet overblik over reglerne for det danske værdipapirmarked, med inddragelse af EU-reglerne. Bogen beskriver i dybden, hvordan det for en virksomhed er at blive noteret på en fondsbørs, en autoriseret markedsplads eller en alternativ markedsplads. Kapitalmarkesdets tjenesteydere ...

  20. The Design Points of RS232 -RS422/RS485/TLL Signal Converter%RS232-RS422/RS485/TLL信号转换器设计

    Institute of Scientific and Technical Information of China (English)

    苏燕; 周士龙

    2012-01-01

    主要介绍了RS232-RS422/485信号转换器在窃电电路、自动方向转换电路、RS232信号补偿电路的设计要点,提出了将RS422接口与TLL接口兼容使用的方法。%This article mainly introduces design points of the RS232 -RS422/485 signal converter's getting power supply from signal pins circuit, automatic direction of transform circuit and RS232 signal compensation circuit. It puts forward the RS422 interface and TLL interface compatibility methods

  1. Household food availability in Pelotas, Brazil: An approach to assess the obesogenic environment

    Directory of Open Access Journals (Sweden)

    Ana Luiza Gonçalves Soares

    2014-04-01

    Full Text Available OBJECTIVE: To identify household food availability according to socioeconomic and demographic factors. METHODS: A cross-sectional, population-based study was carried out in the city of Pelotas, Southern Brazil to determine household food availability in the 30 days that preceded the interview. Availability was considered high when food was "always" or "usually" available at home. The independent variables were: age and education level of the household head, number of household members, presence of children or adolescents, National Wealth Score, and family income. RESULTS: Data were collected from 1,555 households. A high availability of fruits and vegetables (80% was more prevalent than that of soft drinks, processed meats, and sweets (40%. Whole grains and frozen foods were never available in half of the households. High-sugar and high-fat foods were positively related and fruits and whole grains were negatively related to the presence of children or adolescents in the household. National Wealth Score, family income, and age and education level of the household head were associated with household food availability. CONCLUSION: Socioeconomic factors and demographic characteristics were associated with household food availability. High household availability of fruits and vegetables, together with sweets, processed meats, and soft drinks suggests the complex eating practices of a household, impairing classifying the environment as obesogenic.

  2. Intrauterine exposure to smoking and wheezing in adolescence: the 1993 Pelotas Birth Cohort.

    Science.gov (United States)

    Werhmeister, F C; Nunes, B P; Loret de Mola, C; Gómez-Cofré, N; de Oliveira, P D; Marco, P L; Assunção, M C F; Gonçalves, H; Horta, B L; Menezes, A M B

    2015-06-01

    Previous studies have suggested an association between maternal smoking during pregnancy and asthma symptoms such as wheezing during childhood. However, few have evaluated this association in adolescence, especially in populations with high prevalence of wheezing as in Brazil. Using the 1993 Pelotas birth cohort, a longitudinal study set in southern Brazil of 5249 urban live births, we aimed to evaluate the association between maternal and the partner's smoking during pregnancy and wheezing at 11 and 15 years of age. We evaluated smoking during pregnancy using number of cigarettes/day, and our main outcomes were as follows: wheezing in the last year and number of wheezing crises, at both 11 and 15 years of age, as well as persistent wheezing (having crises at 11 and 15 years of age) and medical asthma diagnosis at age 15. In addition, other socio-demographic variables were included as possible confounders and mediators of this association. We used Poisson regression models to evaluate crude and adjusted associations. Of the 5249 live births in 1993, 87.5% and 85.7% were followed-up to 11 and 15 years of age, respectively. Maternal smoking during pregnancy showed a dose-response association with number of wheezing crises at age 15 (P = 0.023), presence of persistent wheezing (P = 0.034) and asthma diagnosis (P = 0.023). Partner's smoking was not associated with any wheezing variables. Maternal smoking during pregnancy appears to exert an effect on respiratory morbidity of adolescents, evaluated by wheezing symptoms.

  3. Recent structural studies on Dom34/aPelota and Hbs1/aEF1α: important factors for solving general problems of ribosomal stall in translation.

    Science.gov (United States)

    Kobayashi, Kan; Ishitani, Ryuichiro; Nureki, Osamu

    2013-01-01

    In the translation process, translating ribosomes usually move on an mRNA until they reach the stop codon. However, when ribosomes translate an aberrant mRNA, they stall. Then, ribosomes are rescued from the aberrant mRNA, and the aberrant mRNA is subsequently degraded. In eukaryotes, Pelota (Dom34 in yeast) and Hbs1 are responsible for solving general problems of ribosomal stall in translation. In archaea, aPelota and aEF1α, homologous to Pelota and Hbs1, respectively, are considered to be involved in that process. In recent years, great progress has been made in determining structures of Dom34/aPelota and Hbs1/aEF1α. In this review, we focus on the functional roles of Dom34/aPelota and Hbs1/aEF1α in ribosome rescue, based on recent structural studies of them. We will also present questions to be answered by future work.

  4. Avaliação das boas práticas adotadas nas cozinhas hospitalares da cidade de Pelotas/RS

    OpenAIRE

    Gonçalves, Juliana Macedo; Buchweitz, Márcia Rúbia Duarte; Rodrigues,Kelly Lameiro; Almeida, Ângela Teresinha Santiago

    2012-01-01

    Em unidades hospitalares, vários critérios são estabelecidos com a finalidade de recuperar a saúde do paciente, entre elas o consumo da alimentação hospitalar, que deve estar adequada do ponto de vista higiênico e sanitário. A legislação sanitária brasileira exige dos estabelecimentos produtores e/ou manipuladores de alimentos a implantação das Boas Práticas, que são procedimentos padronizados que visam prevenir o surgimento de toxinfecções alimentares. O objetivo deste estudo foi realizar...

  5. Avaliação das boas práticas adotadas nas cozinhas hospitalares da cidade de Pelotas/RS

    OpenAIRE

    Gonçalves, Juliana Macedo

    2012-01-01

    Em unidades hospitalares, vários critérios são estabelecidos com a finalidade de recuperar a saúde do paciente, entre elas o consumo da alimentação hospitalar, que deve estar adequada do ponto de vista higiênico e sanitário. A legislação sanitária brasileira exige dos estabelecimentos produtores e/ou manipuladores de alimentos a implantação das Boas Práticas, que são procedimentos padronizados que visam prevenir o surgimento de toxinfecções alimentares. O objetivo deste estudo foi reali...

  6. Elaboración y validación biomecánica de un guante de protección para jugar a pelota valenciana. (Elaboration and biomechanical validation of a protection glove for playing pelota valenciana.

    Directory of Open Access Journals (Sweden)

    Carlos Montaner-Sesmero

    2012-10-01

    Full Text Available ResumenLa pelota valenciana es uno de los antiguos juegos de pelota a mano que perdura en la Comunidad Valenciana. Para amortiguar los impactos de la pelota durante el golpeo, los jugadores se confeccionan sus propias protecciones. En torno a ellas existen diversos factores que dificultan la práctica segura y eficaz de este deporte: el excesivo tiempo empleado en su elaboración, el elevado número de lesiones que sufren en las manos o el inadecuado control de la pelota que consiguen. En base a esto y a la inexistencia de un equipamiento deportivo específico para la mano, se ha desarrollado y validado un guante para intentar solventar estos inconvenientes. En la validación biomecánica se comparó el guante con una protección tipo a nivel de presiones palmares y de precisión y distancia alcanzada en el golpeo. También se registró la opinión de los jugadores acerca del guante con una encuesta. En el ensayo biomecánico participaron 15 jugadores. Para el registro de las presiones palmares se utilizó el equipo Biofoot/IBV® adaptado a la mano. Los resultados muestran que el guante disminuye la presión en tres zonas de la mano, que ofrece la misma precisión y que favorece una mayor distancia de golpeo que las protecciones tradicionales. Los jugadores han valorado satisfactoriamente aspectos como la usabilidad, el ajuste y el confort térmico. En consecuencia, el guante desarrollado disminuye el tiempo de colocación, ofrece mejores prestaciones de protección y es valorado positivamente por los jugadores.Abstract The pelota valenciana game is one of the ancient ball hand game that lasts in the Valencian Community. The players, in order to cushion the hand impacts of the ball during the hits, make their own protections. Around them there are several factors that impede the safe and effective practice of this sport: the excessive time spent in the manufacture, the high number of hand injuries suffered or the inappropriate control of the

  7. Transmitting RS232/RS485 signal via fiber achieved by CPL%光纤传输 RS232/RS485信号的 CPLD 实现

    Institute of Scientific and Technical Information of China (English)

    陈振; 王景存; 王祥; 赵煜

    2014-01-01

    In the article, a convert-system is designed base on CPLD, which modulates the RS232/RS485 sig-nal in QDPSK, and converts it to optical signal, then transmits the signal via optical fiber, so that the system achieves the long-distance communication of RS232/RS485. It can be seen from the result of the experimental test and field operating that the system has a good performance, and can be a solution of the long-distance communication of RS232/RS485.%基于CPLD设计一个转换系统,对RS232/RS485信号进行QDPSK调制,并转换成光信号,利用光纤进行传输,实现了RS232/RS485的远距离通信。通过实验测试和现场运行结果来看,本系统性能良好,可以作为一种RS232/RS485远距离通信的解决方案。

  8. Formas de condicionar la verdad con el uso del montaje en La pelota vasca

    Directory of Open Access Journals (Sweden)

    María Antonia Paz Rebollo

    2011-01-01

    Full Text Available Esta investigación tiene como objetivo estudiar la construcción de sentido en La pelota vasca. La piel contra la piedra (Julio Medem, 2003, el documental sobre terrorismo que más éxito comercial y más polémica ha generado en el cine español. A través de un análisis del montaje, este artículo busca descubrir las pautas, esquemas o estructuras narrativas utilizadas por el director para construir el texto fílmico y para influir en la opinión de los espectadores. Para ello se ha creado una base de datos que permite un minuicioso análisis cuantitativo y cualitativo de todAs las intervenciones que hay en la película. Esta propuesta metodológica pretende servir al análisis de otros documentales con similares características narrativas. Las conclusiones obtenidas muestran que el director usa la estructura de parte del documental y las entrevistas a diferentes personalidades del País Vasco para configurar un sentido propio de lo que denomina conflicto vasco, que está muy cercano a las tesis nacionalistas. Queda demostrada la crítica a la acción del PP en sus años de gobierno y el deterioro de la imagen del Estado, principalmente a través de un 80% de referencias negativas sobre las fuerzas de seguridad del Estado. También se prueba que las personas entrevistadas son más o menos creíbles dependiendo de cómo quedan situadas dentro del montaje y de si otros personajes refutan o respaldan lo que dicen.

  9. A Novel Route Controlling Begomovirus Resistance by the Messenger RNA Surveillance Factor Pelota.

    Directory of Open Access Journals (Sweden)

    Moshe Lapidot

    2015-10-01

    Full Text Available Tomato yellow leaf curl virus (TYLCV is a devastating disease of tomato (Solanum lycopersicum that can be effectively controlled by the deployment of resistant cultivars. The TYLCV-resistant line TY172 carries a major recessive locus for TYLCV resistance, designated ty-5, on chromosome 4. In this study, the association between 27 polymorphic DNA markers, spanning the ty-5 locus, and the resistance characteristics of individual plants inoculated with TYLCV in 51 segregating recombinant populations were analyzed. These analyses localized ty-5 into a 425 bp region containing two transversions: one in the first exon of a gene encoding the tomato homolog of the messenger RNA surveillance factor Pelota (Pelo, and a second in its proximal promoter. Analyses of susceptible and resistant lines revealed that the relative transcript level of the gene remained unchanged, regardless of whether the plants were infected with TYLCV or not. This suggests that the polymorphism discovered in the coding region of the gene controls the resistance. Silencing of Pelo in a susceptible line rendered the transgenic plants highly resistant, while in the resistant line TY172 had no effect on symptom development. In addition, over-expression of the susceptible allele of the gene in the resistant TY172 line rendered it susceptible, while over-expression of the resistant allele in susceptible plants had no effect. These results confirm that Pelo is the gene controlling resistance at the ty-5 locus. Pelo, implicated in the ribosome recycling-phase of protein synthesis, offers an alternative route to promote resistance to TYLCV and other viruses.

  10. Inequities in maternal postnatal visits among public and private patients: 2004 Pelotas cohort study

    Directory of Open Access Journals (Sweden)

    Marco Paula L

    2009-09-01

    Full Text Available Abstract Background The postnatal period is the ideal time to deliver interventions to improve the health of both the newborn and the mother. However, postnatal care shows low-level coverage in a large number of countries. The objectives of this study were to: 1 investigate inequities in maternal postnatal visits, 2 examine differences in postnatal care coverage between public and private providers and 3 explore the relationship between the absence of maternal postnatal visits and exclusive breastfeeding, use of contraceptive methods and maternal smoking three months after birth. Methods In the calendar year of 2004 a birth cohort study was started in the city of Pelotas, Brazil. Mothers were interviewed soon after delivery and at three months after birth. The absence of postnatal visits was defined as having no consultations between the time of hospital discharge and the third month post-partum. Logistic regression analysis was used to estimate the association between absence of postnatal visits and type of insurance scheme adjusting for potential confounding factors. Results Poorer women, black/mixed, those with lower level of education, single mothers, adolescents, multiparae, smokers, women who delivered vaginally and those who were not assisted by a physician were less likely to attend postnatal care. Postnatal visits were also less frequent among women who relied in the public sector than among private patients (72.4% vs 96% among public and private patients, respectively, x2 p Conclusion Postpartum care is available for every woman free of charge in the Brazilian Publicly-funded health care system. However, low levels of postpartum care were seen in the study (77%. Efforts should be made to increase the percentage of women receiving postpartum care, particularly those in socially disadvantaged groups. This could include locally-adapted health education interventions that address women's beliefs and attitudes towards postpartum care. There

  11. Trabalho infantil em Pelotas: perfil ocupacional e contribuição à economia

    Directory of Open Access Journals (Sweden)

    Facchini Luiz Augusto

    2003-01-01

    Full Text Available O trabalho infantil é um fenômeno global de grandes proporções, especialmente em países em desenvolvimento. Estima-se que, em todo o mundo, 352 milhões de crianças e adolescentes menores de 18 anos são economicamente ativos, incluindo atividades remuneradas, trabalho não-pago, ilegal e no setor informal da economia. No Brasil, cerca de 9,3 milhões de crianças entre 10 e 17 anos trabalham. Os estudos sobre a contribuição econômica das crianças à renda familiar são escassos. Este artigo apresenta o perfil ocupacional e a contribuição econômica de crianças e adolescentes, com destaque para aspectos relacionados à idade, ao gênero, à escolaridade e à situação socioeconômica de suas famílias em uma amostra de 4.924 indivíduos entre 6 e 17 anos, representativa dos setores urbanos pobres de Pelotas. As crianças e adolescentes trabalhadores contribuíam em média com 18% da renda familiar. Dos que trabalhavam, metade contribuía no mínimo com 10% da renda familiar e um quarto respondia por 25% ou mais da renda familiar. Quanto menor a renda familiar dos adultos, maior a proporção da contribuição de crianças e adolescentes à renda familiar total, maior a exclusão escolar de adolescentes trabalhadores e maior a jornada de trabalho infanto-juvenil.

  12. Trabalho infantil em Pelotas: perfil ocupacional e contribuição à economia

    Directory of Open Access Journals (Sweden)

    Luiz Augusto Facchini

    Full Text Available O trabalho infantil é um fenômeno global de grandes proporções, especialmente em países em desenvolvimento. Estima-se que, em todo o mundo, 352 milhões de crianças e adolescentes menores de 18 anos são economicamente ativos, incluindo atividades remuneradas, trabalho não-pago, ilegal e no setor informal da economia. No Brasil, cerca de 9,3 milhões de crianças entre 10 e 17 anos trabalham. Os estudos sobre a contribuição econômica das crianças à renda familiar são escassos. Este artigo apresenta o perfil ocupacional e a contribuição econômica de crianças e adolescentes, com destaque para aspectos relacionados à idade, ao gênero, à escolaridade e à situação socioeconômica de suas famílias em uma amostra de 4.924 indivíduos entre 6 e 17 anos, representativa dos setores urbanos pobres de Pelotas. As crianças e adolescentes trabalhadores contribuíam em média com 18% da renda familiar. Dos que trabalhavam, metade contribuía no mínimo com 10% da renda familiar e um quarto respondia por 25% ou mais da renda familiar. Quanto menor a renda familiar dos adultos, maior a proporção da contribuição de crianças e adolescentes à renda familiar total, maior a exclusão escolar de adolescentes trabalhadores e maior a jornada de trabalho infanto-juvenil.

  13. CHAAJ (JUEGO DE PELOTA MESOAMERICANO: UN jUEGO ANCESTRAL ENTRE EMERGENCIAS CULTURALES

    Directory of Open Access Journals (Sweden)

    Jairzinho Francisco Panqueba Cifuentes

    2012-06-01

    Full Text Available Los juegos de pelota mesoamericanos son manifestaciones corporales que han sido exploradasprincipalmente desde perspectivas arqueológicas e históricas, pero también han sido retomadosdesde distintas iniciativas para ponerlos en práctica. Desde la frontera entre Estados Unidos conMéxico, pasando por distintos Estados del país “azteca”, son practicadas diferentes modalidades deeste juego. Sin embargo, decir que el chaaj en Mesoamérica es hoy en día una alternativa recreativay deportiva, es quedarse corto respecto a su ya demostrado potencial. La sacralidad manifestada através de los movimientos corporales está ofreciendo opciones de innovación en varios espacios de lassociedades actuales. En su dimensión ceremonial, revela una comunicación ancestral muy actual. Allíse ponen en juego los códices, las interpretaciones arqueológicas y los conocimientos territoriales depersonas sabedoras de las comunidades. En su dimensión lúdica, el juego reúne elementos culturales,deportivos y pedagógicos. Ha sido una práctica corporal, técnica y motora ejecutada constantementeen algunas regiones mexicanas y guatemaltecas. No obstante su antigüedad, en los últimos años seviene registrando una promoción inusitada, en medio de los actuales tiempos de cambio que fueronanunciados desde tiempos inmemoriales por los sabedores y las sabedoras mayas.

  14. Exposição ocupacional por material biológico no Hospital Santa Casa de Pelotas - 2004 a 2008 La exposición ocupacional a material biológico en el Hospital Santa Casa de Pelotas - 2004 a 2008 Occupational exposure to biological material at the Hospital Santa Casa de Pelotas - 2004 to 2008

    OpenAIRE

    2011-01-01

    A pesquisa trata de exposições ocupacionais por material biológico a que foram submetidos os profissionais de saúde, no Hospital Santa Casa de Misericórdia de Pelotas, no período de janeiro de 2004 a junho de 2008. Trata-se de um estudo transversal, descritivo, com abordagem quantitativa. Utilizou-se como instrumento de pesquisa um questionário elaborado com base na ficha de notificação de acidente de trabalho da referida instituição. Os dados foram digitados e analisados no programa Epi-info...

  15. Analizador de protocolo rs-232

    OpenAIRE

    Caicedo Mejillones, Steven Kleber; Paredes Cedeno, Jeanneth Mirelly; Ponguillo Intriago, Ronald

    2014-01-01

    En el presente trabajo se desarrolló una herramienta que servirá para capturar y analizar las tramas que se intercambian entre dos dispositivos que se comunican usando el protocolo de comunicación serial RS-232. La información capturada se muestra en una Computadora Personal o en un Dispositivo Móvil con Sistema Operativo Android; esto nos permitirá entender e interpretar el funcionamiento del protocolo antes mencionado, además nos ayudará en la tarea de detectar y resolver problemas relacion...

  16. Medindo o impacto da promoção do aleitamento materno em serviços de atenção primária à saúde em Pelotas, Rio Grande do Sul, Brasil Measuring the impact of promoting breastfeeding in primary health care services in Pelotas, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Marilda B. Neutzling

    1993-06-01

    Full Text Available Através da aplicação de um questionário padronizado a todas as mães que procuraram os serviços de puericultura das unidades sanitárias (US da Universidade Federal de Pelotas (UFPel, RS, em setembro de 1990, buscou-se conhecer o impacto dos grupos de gestantes na promoção do aleitamento materno. Os resultados obtidos para 347 crianças revelaram que quase metade delas pertencia a famílias com renda inferior a dois salários mínimos mensais; 1/4 de suas mães apresentavam escolaridade inferior a quatro anos, sendo estas as que mais frequentaram os grupos. Apesar da maioria das mães ter feito pré-natal e pouco menos da metade ter participado dos grupos de gestantes, 1/3 das crianças estavam desmamadas aos três meses de idade e cerca de 80% delas haviam recebido chás nos primeiros meses. Os dados obtidos revelam um serviço com sérias deficiências em incentivar o aleitamento e em retardar a introdução de outros alimentos na dieta infantil. Espera-se, a partir dos dados obtidos, poder contribuir para a reestruturação dos programas existentes, bem como poder demonstrar que, a partir de recursos mínimos e de uma metodologia relativamente simples, é possível avaliar a qualidade dos serviços oferecidos à população.All mothers with children enrolled in the Program for Child Growth and Development at primary care units belonging to the Federal University of Pelotas (UFPel in the state of Rio Grande do Sul, Brazil, were interviewed with a standardized questionnaire. This research aimed to assess the impact of the "Groups of Expecting Mothers" in the promotion of breastfeeding. The family income of almost half of the 347 children studied was two times the minimum wage. About 1/4 of the children's mothers had spent less than four years in school, and these were the mothers who attended the Groups most frequently. Most of the mothers received prenatal care and nearly half of then participated in the Groups. In contrast, 1/3 of the

  17. Prevalence and profile of daily smokers seen at three primary health care units in Pelotas, southern Brazil Prevalência e perfil dos fumantes diários usuários de três unidades básicas de saúde de Pelotas, sul do Brasil

    Directory of Open Access Journals (Sweden)

    Mariane Ricardo Acosta Lopez

    2012-09-01

    Full Text Available Objectives: To estimate the prevalence of daily smoking among users of three primary health care units affiliated with a university hospital in the municipality of Pelotas, southern Brazil, and to identify factors associated with daily tobacco consumption. Methods: This cross-sectional study included all individuals over 14 years of age who sought treatment at the health care units between June 29, 2009, and February 23, 2010, and lived in the area covered by the unit. Interviews were conducted during home visits to collect data on sociodemographic characteristics and health behaviors; the Mini International Neuropsychiatric Interview (MINI was used to assess the presence of mood disorders; and a question from the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST on the daily use of tobacco in the past 3 months was used to assess smoking. Results: The total sample comprised 1,848 individuals, mostly female (72.9%, aged between 46 and 60 years (28.5%, and belonging to socioeconomic class C (61%. The prevalence of daily smoking was 23.4% (n = 432, and there was a statistically significant difference between men and women: 27 vs. 22.1% (p Objetivos: Estimar a prevalência do uso diário de tabaco entre usuários de três unidades básicas de saúde (UBSs vinculadas a um hospital universitário na cidade de Pelotas (RS e identificar fatores associados ao consumo diário de tabaco. Métodos: Participaram deste estudo transversal todos os indivíduos maiores de 14 anos que procuraram atendimento nas UBSs no período de 29 de junho de 2009 a 23 de fevereiro de 2010 e que moravam na área de abrangência da UBS. Entrevistas foram realizadas durante visitas domiciliares para coletar dados sobre características sociodemográficas e comportamentos de saúde; a entrevista estruturada Mini International Neuropsychiatric Interview (MINI foi utilizada para avaliar a presença de transtornos de humor; e uma pergunta do instrumento Alcohol

  18. Polymorphisms FTO rs9939609, PPARG rs1801282 and ADIPOQ rs4632532 and rs182052 but not lifestyle are associated with obesity related-traits in Mexican children

    Directory of Open Access Journals (Sweden)

    C Muñoz-Yáñez

    Full Text Available Abstract Concerning the genetic factors of obesity, no consistent association between populations has been reported, which may be due to the frequency of polymorphisms, the lifestyle of studied populations and its interaction with other factors. We studied a possible association of polymorphisms FTO rs9939609, PPARG rs1801282, and ADIPOQ rs4632532 and rs182052 with obesity phenotypes in 215 Mexican children. Glucose, triglycerides, cholesterol, HDL and LDL were measured. In addition, weight, height, waist circumference and triceps skin thickness were recorded. High-energy diets and sedentary behavior were evaluated with a validated questionnaire. In contrast with other reports, only FTO rs9939609 was associated with obesity related-traits, including BMI (p = 0.03, waist circumference (p = 0.02, triceps skinfold (p = 0.03 and waist/height ratio (p = 0.01, and also with cholesterol levels (p = 0.02 and LDL (p = 0.009. Lower levels of triglycerides (p=0.04 were related with presence of PPARG rs1801282, while ADIPOQ rs4632532 showed an effect on HDL (p = 0.03 levels. On the other hand, diet, physical activity and screen time were not related with obesity. In summary, only FTO rs9939609 was associated with obesity related-traits, while PPARG2 rs1801282 and ADIPOQ rs4632532 were involved in lipid metabolism.

  19. A área do entorno do Mercado Central de Pelotas: comércio formal x comércio informal

    OpenAIRE

    BALSAN, Rosane; Universidade Federal de Pelotas

    2013-01-01

    O presente trabalho tem como objetivo analisar as relações e os conflitos gerados pela organização do comércio informal (camelôs) paralelo ao comércio formal (Mercado Central), na cidade de Pelotas.

  20. BODY COMPOSITION AND SOMATOTYPE OF PROFESSIONAL AND U23 HAND BASQUE PELOTA PLAYERS.

    Science.gov (United States)

    Urdampilleta, Aritz; Mielgo-Ayuso, Juan; Valtueña, Jara; Holway, Francis; Cordova, Alfredo

    2015-11-01

    Introducción: casi no hay ninguna referencia sobre las características antropométricas, la composición corporal y el somatotipo de la mano de los jugadores de pelota vasca (pelotaris) en la literatura científica. Objetivos: el objetivo de esta investigación fue comparar la composición corporal de pelotaris profesionales y sub-23 para crear el perfil antropométrico de este deporte. Métodos: participaron diez pelotaris sub-23 y ocho pelotaris profesionales. Las medidas antropométricas fueron recogidas siguiendo el protocolo de la Sociedad Internacional de Promoción de Protocolo Cineantropometría (ISAK). La masa grasa (FM) se calculó utilizando la ecuación Yushasz modificada por Carter, y la masa muscular (MM) mediante la ecuación de Lee. Los componentes del somatotipo fueron estimados mediante la ecuación Carter y Heath. El nivel de hidratación de los pelotaris se midió con un analizador tetrapolar de impedancia bioeléctrica (BIA). Resultados: los pelotaris profesionales tienen significativamente menor FM (en % (p = 0,001); en kg (p = 0,025) y en los sumatorios de 4, 6 y 8 pliegues cutáneos (p = 0,001); mayor MM (p = 0,015) y un menor componente endomórfico (p < 0,001) que los pelotaris sub-23. Asimismo, los profesionales tienen una mayor cantidad de agua corporal (p = 0,001) y un diámetro mayor biestiloideo de muñeca (p = 0,014). Los pelotaris profesionales son un morfotipo caracterizado por una baja FM (8,9 ± 1,1%) y una intermedia MM (47 ± 1,7%), además de tener una altura de 183,0 ± 7,1 cm y un peso de 85,9 ± 7,6 kg. Conclusión: los principales resultados de este estudio mostraron que las características antropométricas no modificables por el entrenamiento (por ejemplo, altura, envergadura y diámetro de la muñeca) son componentes importantes para convertirse en un pelotari profesional. Por otra parte, las características relacionadas con el entrenamiento y la dieta han mostrado ser mejores en los pelotaris profesionales (menor FM

  1. Interleukin-6-receptor polymorphisms rs12083537, rs2228145, and rs4329505 as predictors of response to tocilizumab in rheumatoid arthritis.

    Science.gov (United States)

    Enevold, Christian; Baslund, Bo; Linde, Louise; Josephsen, Norah L; Tarp, Ulrik; Lindegaard, Hanne; Jacobsen, Søren; Nielsen, Claus H

    2014-08-01

    Tocilizumab (TCZ), a monoclonal antibody targeting the human interleukin-6-receptor (IL-6R), is indicated for the treatment of rheumatoid arthritis (RA). We examined whether three IL6R single-nucleotide polymorphisms rs12083537, rs2228145 (formerly rs8192284), and rs4329505 with previously reported functional effects were associated with clinical response to TCZ in a retrospective study cohort consisting of 79 RA patients. Three months after initiation of TCZ therapy, changes in swollen joint count (SJC) and, subordinately, tender joint count (TJC), serum-CRP, DAS28-CRP, and EULAR-response were tested for association with the IL6R-haplotype or genotype. The major allele (A) of rs12083537 and the minor allele (C) of rs4329505 were associated with a poor SJC response (P=0.02 and 0.02, respectively). Moreover, the AAC-haplotype (for rs12083537, rs2228145, and rs4329505, respectively) was associated with a poor SJC response (P=0.00004) and, with borderline significance, EULAR-response (P=0.05). These data suggest that genetic variation in IL6R may aid in predicting TCZ therapy outcome in RA patients.

  2. Implementering av RS232-protokoll

    OpenAIRE

    Karlsson, Tomas

    2002-01-01

    Den här rapporten innehåller information om hur man skapar en länk mellan en dator och ett minne via en dators serieport. Ett RS232-protokoll används för att upprätthålla den här länken. För att ta hand om minnet samt upprätthålla kommunikationen med datorn har en FPGA programmerats. Intel hex8 formatet används för datan. Ett program för Windows 98 skapades också. Programmet öppnar en fil och läser tecken. Tecknen översätts till heltal som sänds till serieporten. Programmet kan också spara da...

  3. O ofício de vender o que se ama?: as narrativas de donos de sebos em Pelotas = Is it a craft to sell what one loves?: the narrativas of sebo owners in Pelotas city

    Directory of Open Access Journals (Sweden)

    Marcello Neto, Mario

    2014-01-01

    Full Text Available Este trabalho pretende problematizar a memória construída pelos donos de sebos na cidade de Pelotas. Sebo é o nome atribuído as lojas de vendas de livros, discos (LP’s e quadrinhos usados, porém a origem do termo é de difícil definição (BRITO, 1991. Utilizando a metodologia da História Oral Temática (PORTELLI, 1997 realizamos entrevistas nas quais os narradores compartilharam a sua memória sobre o seu ofício, sua origem e sua importância social para a cidade. Ao total foram 4 narradores, donos e fundadores dos maiores sebos da cidade de Pelotas. Pretendemos problematizar a experiência (THOMPSON, 1991 diferenciada que cada narrador possui sobre o seu ofício. Muitos se consideram bibliófilos (colecionadores de obras raras e valiosas e para isso recorrem à venda de obras “menores” para que possam adquiri-las; outros apenas tratam seu trabalho como um negócio; e ainda há quem classifique o seu trabalho como essencial para a disseminação da leitura na cidade. Nosso objetivo neste trabalhão é compreender a construção dessa memória e a formação de identidade em relação a esse ofício (CANDAU, 2011, bem como a representação (CHARTIER, 1991 que estes narradores fazem de sua inserção na sociedade, o seu papel social. Para muito desses narradores, a metade final do século XX foi definidora para que hoje a demanda por sebos na cidade seja cada vez maior. Porém, nosso objetivo é compreender as narrativas sobre a origem desse ofício, bem como compreender a sua relação para com os objetos vendidos, se há ou não uma relação comercial e/ou afetiva para com os livros e quadrinhos, bem como problematizar a sua memória sobre o seu papel social na disseminação da leitura em Pelotas

  4. Collection of Coleoptera from a poultry farm in Pelotas, Rio Grande do Sul, Brazil Flutuação de Coleoptera em granja avícola, em Pelotas, Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Diego Moscarelli Pinto

    2009-04-01

    Full Text Available To evaluate the population fluctuation of Coleoptera from a poultry farm in Pelotas, Rio Grande do Sul, Brazil, two sampling methods were used: a tube-type trap and a sandwich trap. The analyses of polynomial regression were applied independent of the type of sampling method used. The experiment was carried out for twelve months, from April 2002 to March 2003, in a broiler barn aviary at the Conjunto Agrotécnico Visconde da Graça/UFPEL. A total of 43.945 Coleopterans were captured from the following species: Alphitobius diaperinus, Carcinops troglodytes, Euspilotus rubriculus, Gnathocerus cornutus, Mezium americanum and Somotrichus unifasciatus. Among these, Alphitobius diaperinus was present in all months of the year, with larval population peak in February (235 and lowest capture in August (01. The adult population peak was in March (12,020 and the lowest capture in July (27. The remaining captured Coleopterans did not occur in all twelve months, however they also had population peaks in the months of February and March, which also were the months with the highest temperatures.Para avaliação da flutuação populacional de Coleoptera, em granja avícola, em Pelotas, Rio Grande do Sul, Brasil, foram utilizados dois métodos de coleta: armadilha do tipo tubo e do tipo sanduíche, durante doze meses. A análise de regressão polinomial foi aplicada independentemente do tipo de método de coleta utilizado. O experimento foi conduzido durante 12 meses, de abril de 2002 a março de 2003, em um aviário de aves poedeiras do Conjunto Agrotécnico Visconde da Graça da Universidade Federal de Pelotas (UFPEL. Foram capturados 43.945 Coleopteros das espécies Alphitobius diaperinus, Carcinops troglodytes, Euspilotus rubriculus, Gnathocerus cornutus, Mezium americanum e Somotrichus unifasciatus. Entre esses Coleopteros, Alphitobius diaperinus esteve presente em todos os meses do ano, com pico populacional de larvas em fevereiro (235 e menor índice de

  5. A escola de Belas Artes de Pelotas: aspectos de sua gênese e constituição - The escola de Belas Artes de Pelotas: aspects of its genesis and constitution

    Directory of Open Access Journals (Sweden)

    Clarice Rego Magalhães, Giana Lange do Amaral

    2011-03-01

    Full Text Available Resumo Este trabalho aborda a gênese e constituição de uma instituição de ensino de arte: a Escola de Belas Artes de Pelotas (EBA. O objetivo do estudo é esclarecer quais foram as condições que possibilitaram a criação da EBA em março de 1949. A constituição desta narrativa histórica tem por base fontes escritas, formadas pelos  arquivos  da própria instituição, pelo arquivo particular da família da fundadora da Escola, por periódicos locais e  por  trechos do diário da fundadora, além  de fontes  orais.  Pela análise das fontes,  concluímos que o nascimento da EBA se deu por uma conjunção de  fatores, os quais seriam a vocação cultural da cidade, oriunda da sua história peculiar, e  a  atuação  de   personalidades que,  naquele  momento,   fizeram acontecer o fato histórico. Palavras-chave: Escola de Belas Artes; instituição de  ensino  de arte; história da educação; história das instituições escolares.   THE ESCOLA DE BELAS ARTES DE PELOTAS: ASPECTS  OF ITS GENESIS AND CONSTITUTION Abstract This work examines the genesis and constitution of an art teaching institution: the Escola de Belas Artes de Pelotas (EBA. The purpose of this study is to elucidate the  conditions which made possible the creation of EBA in March, 1949.  This historic account is based on written   sources,  namely  the   institution’s   archives,  the   school founder’s  family private archives, local journals  and  exerts from the founder’s diary, besides oral sources. The analysis of the sources led us to conclude that  the  birth  of EBA  occurred as the  result of a conjunction  of  factors  which are  the  town’s  cultural  inclination, derived from its peculiar history, and the actions of some individuals that, at that moment, made the historic fact happen. Keywords: Fine Arts School; art teaching institution; history of education; teaching institutions history.   LA

  6. Association of EVI5 rs11808092, CD58 rs2300747, and CIITA rs3087456 polymorphisms with multiple sclerosis risk: A meta-analysis

    Directory of Open Access Journals (Sweden)

    Jiahe Liu

    2016-09-01

    Conclusions: The mutant alleles of EVI5 rs11808092 polymorphism may increase the susceptibility to MS while those of CD58 rs2300747 polymorphism may decrease MS risk. In addition, CIITA rs3087456 polymorphism might not be associated with MS.

  7. Characterization of Listeria monocytogenes isolated from a fresh mixed sausage processing line in Pelotas-RS by PFGE Caracterização de Listeria monocytogenes isoladas em uma linha de processamento de lingüiça mista frescal em Pelotas-RS por PFGE

    Directory of Open Access Journals (Sweden)

    Ana Eucares von Laer

    2009-09-01

    Full Text Available Listeria monocytogenes is a bacterium capable to adhere to the surfaces of equipment and utensils and subsequently form biofilms. It can to persist in the food processing environmental for extended periods of time being able to contaminate the final product. The aim of this study was to trace the contamination route of L. monocytogenes on a fresh mixed sausage processing line, from raw material to the final product. The isolates obtained were characterized by serotyping and molecular typing by pulsed-field gel electrophoresis (PFGE using the restriction enzymes ApaI and AscI. L. monocytogenes was detected in 25% of the samples. The samples of raw material were not contaminated, however, the microorganism was detected in 21% of the environmental samples (food contact and non-food contact, 20.8% of the equipments, 20% of the food worker's hands, 40% of the mass ready to packaging and in all the final products samples, demonstrating that the contamination of final product occurred during the processing and the importance of cross contamination. PFGE yielded 22 pulsotypes wich formed 7 clusters, and serotyping yielded 3 serotypes and 1 serogroup, however, the presence of serotypes 4b and 1/2b in the final product is of great concern for public health. The tracing of contamination showed that some strains are adapted and persisted in the processing environment in this industry.Listeria monocytogenes é uma bactéria com capacidade de formar biofilmes e de colonizar superfícies de equipamentos e utensílios. Esse microrganismo pode persistir por longos períodos em plantas de processamento de alimentos, sendo capaz de contaminar o produto final. O objetivo deste estudo foi traçar a rota de contaminação de L. monocytogenes em uma linha de processamento de lingüiça mista frescal, desde a matéria-prima até o produto final. Os isolados obtidos foram caracterizados por sorotipagem e por tipagem molecular, através de Pulsed Field Gel Electrophoresis (PFGE, usando as enzimas de restrição ApaI and AscI. L. monocytogenes foi detectada em 25% das amostras. Nenhuma amostra da matéria-prima apresentava o patógeno, entretanto, o microrganismo foi detectado em 21% das amostras ambientais (com e sem contato com o alimento, 20,8% dos equipamentos, 20% das amostras de mãos de manipuladores, 40% da massa pronta para o embutimento, e em todas as amostras do produto final. Isso demonstra que a contaminação do produto final ocorreu durante o processamento, e a importância da contaminação cruzada. PFGE produziu 22 pulsotipos e a sorotipagem produziu 3 sorotipos e 1 sorogrupo, entretanto, a presença dos sorotipos 4b e 1/2b no produto final é de grande importância para a saúde pública. Os perfis de macrorestrição mostraram que algumas cepas são adaptadas e persistiram no ambiente de processamento dessa indústria.

  8. Funcionalidad de la articulación glenohumeral en el golpe de drive en pelota a paleta

    OpenAIRE

    Doussouk, Karim; Doussouk, Adiel

    2013-01-01

    El propósito de esta ponencia, es realizar un análisis del gesto técnico denominado “Drive”, golpe determinante en la disciplina de Pelota a Paleta, a partir del estudio Anatómico y Biomecánico de la articulación Glenohumeral. Se destacará la importancia de los conocimientos anatomo-funcionales en la formación del Profesor en Educación Física, como base para el análisis del movimiento en cuestión, ya sea con fines de rendimiento deportivo o para mejorar la intervención docente. La articula...

  9. (RS-Efonidipine acetone hemisolvate

    Directory of Open Access Journals (Sweden)

    Yu-Heng Liu

    2016-09-01

    Full Text Available The asymmetric unit of the title compound, C34H38N3O7P·0.5C3H6O {systematic name: (RS-2-[phenyl(phenylmethylamino]ethyl 5-(5,5-dimethyl-2-oxo-1,3-dioxa-2λ5-phosphacyclohex-2-yl-2,6-dimethyl-4-(3-nitrophenyl-1,4-dihydropyridine-3-carboxylate acetone hemisolvate}, contains one R-efonidipine molecule, one S-efonidipine molecule and half of a solvate acetone molecule. In both efonidipine molecules, the six-membered rings of the dioxaphosphinanyl moieties display a chair conformation and the dihydropyridine rings display a flattened boat conformation. In the crystal, N—H...O, C—H...O hydrogen bonds and weak C—H...π interactions link the molecules into a three-dimensional supramolecular structure. A solvent-accessible void of 199 Å3 is found in the structure; the contribution of the heavily disordered solvate molecule was suppressed by use of the SQUEEZE routine in PLATON [Spek (2015. Acta Cryst. C71, 9–18].

  10. The association between four genetic variants in microRNAs (rs11614913, rs2910164, rs3746444, rs2292832 and cancer risk: evidence from published studies.

    Directory of Open Access Journals (Sweden)

    Bangshun He

    Full Text Available MicroRNAs (miRNAs participate in diverse biological pathways and may act as either tumor suppressor genes or oncogenes. Single nucleotide polymorphisms (SNPs in miRNA may contribute to cancer development with changes in the microRNA's properties and/or maturation. Polymorphisms in miRNAs have been suggested in predisposition to cancer risk; however, accumulated studies have shown inconsistent conslusionss. To further validate determine whether there is any potential association between the four common SNPs (miR-196a2C>T, rs11614913; miR-146aG>C, rs2910164; miR-499A>G, rs3746444; miR-149C>T, rs2292832 and the risk for developing risk, a meta-analysis was performed according to the 40 published case-control studies. Odds ratios (ORs with 95% confidence intervals (CIs were calculated to assess the extent of the association. The results demonstrated that the rs11614913TT genotype was significantly associated with a decreased cancer risk, in particular with a decreased risk for colorectal cancer and lung cancer, or for Asian population subgroup. In addition, the rs2910164C allele was associated with decreased risk for esophageal cancer, cervical cancer, prostate cancer, and hepatocellular carcinoma (HCC, in particular in Asian population subgroup. Similarly, the rs3746444G allele was observed as a risk factor for cancers in the Asian population. It is concluded that two SNPs prsent in miRNAs(rs11614913TT, and rs2910164C may protect against the pathogenesis of some cancers, and that the rs3746444 may increase risk for cancer.

  11. Rs6454674, Rs806368 and Rs1049353 CNR1 Gene Polymorphisms in Turkish Bipolar Disorder Patients: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Gokay Alpak

    2014-04-01

    Full Text Available Bipolar disorder (BD is one of the most prevalent psychiatric disorders in clinical practice. The etiology of the BD is not thoroughly understood. Endocannabinoid system, which is involved in regulation of emotion, stress, memory, and cognition, may have an important role in the pathophysiology of BD. Mutations on the cannabinoid-1 receptor (CNR1 gene are associated with several psychiatric disorders. The main cannabinoid (CB receptor is CB1 and its activation inhibits neuronal depolarization. One previous study showed rs1049353 polymorphism of CNR1 gene is associated with major depression but not with BD. In this study, we aimed to investigate the rs6454674, rs806368 and rs1049353 CNR1 gene polymorphisms in Turkish BD patients. A total of 96 patients and 58 healthy controls were included in the current case-control study. Blood samples of study participants were collected into sterile tubes and processed to obtain genomic DNA. Restriction Fragment Length Polymorphism analysis were done by digesting the PCR products with HpyCH4III and BseGI enzymes for the rs6454674 and rs806368 restriction sites, respectively. Single-Strand Conformation Polymorphism (SSCP analysis was also performed. Among three polymorphisms investigated in this study, only rs6454674 polymorphism was significantly different between BD patients and controls (rs6454674 T/G; p=0.042, rs806368 T/C; p>0.05, rs1049353 A/G; p>0.05. Furthermore, we found that the mean of the yearly manic attacks was statistically higher in patients who have heterozygote (0.91+/-0.67 rs6454674 T/G polymorphisms compared to those with homozygote (p=0.043 polymorphism. The post-hoc analysis showed that the main differences were between the heterozygotes genotype and non-mutant (GG homozygotes (0.42+/-0.31; p=0.037 but not in homozygote mutant genotype (0.74+/-0.74; p=0.149. When patients were compared with the other clinical parameters, and mutated alleles and genotypes for each polymorphism, we did not

  12. Lack of association between TESPA1 gene polymorphisms (rs1801876, rs2171497, rs4758994, and rs997173) and ankylosing spondylitis in a Chinese population.

    Science.gov (United States)

    Liu, Si; Liu, Li; Wu, Shanshan; Yang, Ting; Pan, Faming; Laslett, Laura; Xia, Guo; Hu, Yanting; Fan, Dazhi; Ding, Ning; Xu, Shengqian; Cai, Guoqi; Wang, Li; Xin, Lihong

    2014-12-01

    We investigated whether TESPA1 gene polymorphisms were associated with increased risk of developing ankylosing spondylitis (AS). We also studied whether TESPA1 gene interacts with environmental factors. A total of 494 patients with AS and 478 matched healthy controls were genotyped for four SNPs (rs1801876, rs2171497, rs4758994, and rs997173) in the TESPA1 gene. We found no evidence of association between these SNPs and AS susceptibility, and between their haplotypes and the disease. But, patients with rs1801876 GA, GG, and AA genotypes had significantly different Bath Ankylosing Spondylitis Functional Index (BASFI) scores (p = 0.023). There were significantly different visual analogue scale (VAS) night pain assessment scores (p = 0.040) and BASFI scores (p = 0.023) among different genotypes at rs2171497 locus. There were also significantly different chest expansion scores (p = 0.042) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores (p = 0.014) among different genotypes at rs997173 locus. For multiple testing, Bonferroni correction was performed. After Bonferroni correction, clinical characteristics of these three loci showed association between different genotype groups. These findings indicated that the TESPA1 gene is not involved in AS genetic predisposition in the Han Chinese population; however, it may play an important role in the clinical characteristics of AS.

  13. Serial Interface Converter Between RS232 and RS485%串行通信RS232/RS485转换器

    Institute of Scientific and Technical Information of China (English)

    邓素萍

    2001-01-01

    文章介绍了美国德州仪器公司生产的一种RS485接口芯片SN75LBC184的主要特点和功能,给出了一种低成本、带光电隔离的RS232/RS485转换器的设计电路.该转换器电路结构简单,工作可靠,能满足大部分工业现场控制场合的使用要求.

  14. Search for RS-gravitons at CDF

    Energy Technology Data Exchange (ETDEWEB)

    Strologas, John; /New Mexico U.

    2011-09-01

    We present a search for Randall-Sundrum (RS) gravitons decaying to diphotons or dielectrons or dimuons, performed with the CDF II detector and using up to 5.7 fb{sup -1} of integrated luminosity. The respective mass spectra are consistent with the ones expected by the standard model. For the RS-model parameter k/{bar M}{sub Pl} = 0.1, RS-gravitons with mass less than 1111 GeV/c{sup 2} are excluded at 95% CL.

  15. Tabaco, álcool e outras drogas entre adolescentes em Pelotas, Rio Grande do Sul, Brasil: uma perspectiva de gênero Tobacco, alcohol, and drug use by teenagers in Pelotas, Rio Grande do Sul State, Brazil: a gender approach

    Directory of Open Access Journals (Sweden)

    Rogério Lessa Horta

    2007-04-01

    Full Text Available Este estudo teve o objetivo de examinar a relação entre gênero e utilização de substâncias psicoativas entre adolescentes (consumo de bebidas alcoólicas, fumo e uso de drogas ilícitas. Em 2002 foi realizado um estudo transversal na área urbana de Pelotas, extremo-sul do Brasil. Foi empregada amostragem em múltiplos estágios para se obter uma amostra de adolescentes entre 15 e 18 anos de idade. As entrevistas foram realizadas com questionário auto-aplicado. Tabagismo foi mais prevalente entre as meninas, enquanto o consumo de bebida alcoólica no mês anterior às entrevistas foi maior entre os meninos. Por outro lado, a proporção de adolescentes que relataram uso de drogas ilícitas no mês que antecedeu as entrevistas não esteve relacionada ao gênero. O maior consumo de tabaco entre meninas que entre meninos pode indicar risco de expansão do consumo desta substância por mulheres de outras faixas etárias em gerações futuras, o que justifica preocupação e esforços específicos.This study assesses the relationship between gender and use of psychoactive substances (alcohol, nicotine, and illicit drugs by teenagers. In 2002, a cross-sectional study was carried out in the urban area of Pelotas, southern Brazil. Multi-stage sampling was used to obtain a sample of adolescents, 15 to 18 years of age. Subjects were interviewed using a self-applied confidential questionnaire. Smoking was more prevalent among girls, while alcohol consumption in the previous month was more common among boys. Meanwhile, the proportion of adolescents that reported drug use in the previous month was unrelated to gender. Higher cigarette consumption by girls suggests an increase in smoking by women in the future, which highlights the need for a special focus on this area.

  16. Qualidade do ambiente e fatores associados: um estudo em crianças de Pelotas, Rio Grande do Sul, Brasil Quality of the environment and associated factors: a pediatric study in Pelotas, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Maria de Fátima Duarte Martins

    2004-06-01

    Full Text Available Descrever e identificar fatores que possam estar associados à qualidade do ambiente e características das crianças expostas, em Pelotas, Rio Grande do Sul, Brasil. Trata-se de um estudo prospectivo de caráter populacional, incluindo 630 crianças da coorte de nascimentos de 1993. No ano de 1998 avaliou-se, entre outras informações, a qualidade do ambiente, medida através do Home Observation for the Measurement of the Environment. Os dados foram analisados por meio de análise univariada. A associação entre as variáveis e o desfecho foi avaliada por meio das razões de prevalência, dos intervalos de confiança em 95% e do qui-quadrado. Realizou-se a regressão logística seguindo modelo hierarquizado. Constatou-se que 97 crianças (15% viviam em ambiente negativo. Encontraram-se oito fatores de risco associados à qualidade do ambiente: baixa renda familiar mensal, baixa escolaridade materna, sexo masculino, casas com mais de sete residentes, número de irmãos maior ou igual a quatro, uso de tabaco na gestação, crianças que dormem na cama dos pais aos 4 anos e mães com presença de transtornos psiquiátricos.This study aims to describe and identify factors associated with environmental quality and characteristics of children exposed to environmental risk factors in Pelotas, Rio Grande do Sul, Brazil. This was a prospective, population-based study, including 630 children from the 1993 birth cohort. During the year 1998, environmental quality and other information were assessed using the Home Observation for the Measurement of the Environment. Data were submitted to univariate analysis. The association between the variables and the outcome was evaluated through prevalence ratios, 95% confidence intervals, and chi-square. Logistic regression was performed according to a hierarchical model. Some 97 children (15% were living in negative environments. Eight risk factors were associated with environmental quality: low monthly family

  17. Prevalence of suicide risk and comorbidities in postpartum women in Pelotas Prevalência do risco de suicídio e de comorbidades em mulheres pós-parto em Pelotas

    Directory of Open Access Journals (Sweden)

    Daniele Tavares

    2012-10-01

    Full Text Available OBJECTIVES: To evaluate the prevalence of suicide risk and comorbidities in postpartum women. METHODS: This is a cross-sectional study of postpartum women. The sample comprised mothers who have received prenatal care from the Brazilian National System of Public Heath in the city of Pelotas. Suicide risk and other mental disorders were evaluated using the Mini International Neuropsychiatric Interview (MINI. A yes answer on one of the six interview questions was considered a sign of suicide risk. RESULTS: The sample consisted of 919 postpartum women. The 11.5% suicide prevalence was 4.62 (CI 2.45, 8.73 times higher in women with low educational levels. Women with comorbid depression or an anxiety disorder showed a 17.04 (CI 2.27; 19.96 times greater risk of suicide than those who did not suffer from any mood disorder. CONCLUSION: Lower education levels and psychiatric disorders are associated with suicide risk. Bipolar disorder is the psychiatric disorder with the highest impact on suicide risk.OBJETIVOS: Avaliar a prevalência do risco de suicídio e de comorbidades em mulheres pós-parto. MÉTODOS: Este foi um estudo em corte transversal com mulheres pós-parto. A amostra foi constituída de mães que receberam cuidados pré-natais prestados pelo Sistema Nacional de Saúde Pública do Brasil na cidade de Pelotas. O risco de suicídio e outros transtornos mentais foram avaliados pela Mini International Neuropsychiatric Interview (MINI. Uma resposta afirmativa a qualquer das seis perguntas é considerada um risco de suicídio. RESULTADOS: A amostra consistiu de 919 mulheres pós-parto. A prevalência do risco de suicídio foi de 11,5%. Ela foi 4,62 vezes mais alta (IC de 95% 2,45; 8,73 em mulheres de baixo nível educacional. Mulheres apresentando qualquer comorbidade para depressão e transtornos ansiosos tiveram uma chance 17,04 vezes maior (IC 95% 2,27; 19,96 àquelas que não apresentaram nenhum transtorno afetivo. CONCLUSÃO: Um n

  18. Auto-estima e fatores associados em gestantes da cidade de Pelotas, Rio Grande do Sul, Brasil Self-esteem and associated factors in pregnant women in the city of Pelotas, Rio Grande do Sul State, Brazil

    Directory of Open Access Journals (Sweden)

    Michelle de Souza Dias

    2008-12-01

    Full Text Available O estudo tem como objetivo mensurar a auto-estima e fatores associados em gestantes atendidas pelo Sistema Único de Saúde (SUS na cidade de Pelotas, Rio Grande do Sul, Brasil. É do tipo transversal, tendo-se entrevistado 560 gestantes nos meses de maio a novembro de 2006, nos ambulatórios e enfermarias dos hospitais universitários e do centro de atendimento da Prefeitura Municipal. Dentre as gestantes atendidas, 62,9% receberam o diagnóstico de alto-risco. Para avaliação da auto-estima foi utilizada a escala de Rosenberg. Na amostra total a média de pontos na escala foi de 9,2 e o desvio-padrão de 4,6. As variáveis associadas positiva e significativamente com auto-estima foram idade, nível de escolaridade e nível econômico. Já as variáveis percepção de risco à saúde do bebê e número de gestações mostraram-se associadas negativamente à auto-estima. Além disso, as gestantes com condição gestacional de alto-risco têm uma auto-estima mais elevada quando comparadas com as de baixo-risco.This study analyzes self-esteem and associated factors in pregnant women treated by the Unified National Health System (SUS in the city of Pelotas, Rio Grande do Sul State, Brazil. Using a cross-sectional design, 560 pregnant women were interviewed from May to November 2006. The interviews were held in specific locations like University outpatient clinics and hospital wards and a center run by the city government. A full 62.9% were diagnosed as high-risk pregnancies. Mean self-esteem according to the Rosenberg scale was 9.2 (SD = 4.6. Variables showing a positive, significant association with self-esteem were age, schooling, and income. Perception of risk to the unborn infant's health and parity were both negatively associated with maternal self-esteem. These high-risk pregnant women also showed higher self-esteem than low-risk pregnant women.

  19. 自制RS232/RS485转换器应用%Long Distance Communication based Changed of RS232/RS485

    Institute of Scientific and Technical Information of China (English)

    孙东; 韩绍坤; 邢怀飞

    2005-01-01

    文中阐述RS232/RS485转换器的电路设计,以及结合VB6的MSComm控件和松下电工的MEWTOCOL-COM协议,实现小型集散式控制系统的软硬件设计.具有成本低、易于开发、远距离、抗干扰等特点

  20. THE STUDY OF A NEW TYPE OF RS232 TO RS485 CONVERTOR%RS232至RS485转换器的研究

    Institute of Scientific and Technical Information of China (English)

    黎永光; 金伟正

    2002-01-01

    介绍一种RS232至RS485转换器的原理.给出该转换器的硬件原理图.该转换器能设定波特率(BaudRate)及自动识别数据流的传输方向,非常适合于网络型温度传感器的组网.

  1. Environment sensitivity map to North Pelotas Basin: subsidy to elaboration of contingency plans; Mapeamento da sensibilidade ambiental para a porcao norte da Bacia de Pelotas: subsidio para elaboracao de planos de contingencia

    Energy Technology Data Exchange (ETDEWEB)

    Diniz, Debora P.; Griep, Gilberto H. [Fundacao Universidade do Rio Grande (FURG), RS (Brazil)

    2008-07-01

    The Pelotas Basin stands out in the national scenery of search of petroleum and gas. Due of these interests they become important environmental protection actions. Inside of this panorama is the Chart of Sensitivity Index (CSI). The study was developing in Santa Catarina, municipal districts from Passo de Torres to Palhoca. The objectives of this work were the development of the CSI and the construction of a bibliographical database. The methodology used in this work was proposed by the Ministerio do Meio Ambiente. During the field exit sediment samples, photographic registration and pertinent observation were collected. With all this information the Index of Environment Sensitivity (IES) was generated, that classifies the coasts in agreements with the sensitivity to the oil. Diversity of environments is very clear at this coast for the variability of the IES. The most frequent ecosystem is beaches of medium to fine sand exposed. It was identified the presence of environments of highly sensitive, classified in the index 8 and 10. The definition of possible scarification areas was accomplishments with IES, biological resources and economical partner of the area. (author)

  2. Exposição ocupacional por material biológico no Hospital Santa Casa de Pelotas - 2004 a 2008 La exposición ocupacional a material biológico en el Hospital Santa Casa de Pelotas - 2004 a 2008 Occupational exposure to biological material at the Hospital Santa Casa de Pelotas - 2004 to 2008

    Directory of Open Access Journals (Sweden)

    Lílian Moura de Lima

    2011-03-01

    Full Text Available A pesquisa trata de exposições ocupacionais por material biológico a que foram submetidos os profissionais de saúde, no Hospital Santa Casa de Misericórdia de Pelotas, no período de janeiro de 2004 a junho de 2008. Trata-se de um estudo transversal, descritivo, com abordagem quantitativa. Utilizou-se como instrumento de pesquisa um questionário elaborado com base na ficha de notificação de acidente de trabalho da referida instituição. Os dados foram digitados e analisados no programa Epi-info 6.04. Como principal resultado encontrou-se a maior ocorrência de acidentes de trabalho com material biológico entre os profissionais técnicos em enfermagem do sexo feminino (38,6%, com idade de 21 a 30 anos (53,9%. A maioria dos acidentes aconteceu através de lesões com perfurocortantes (82,2%, sendo 24,1% no Centro Cirúrgico e 84,5% envolvendo sangue. Conclui-se que o estudo é de extrema relevância, pois, com base no reconhecimento do tipo de acidentes mais frequentes, pode-se conhecer os riscos existentes e intervir na sua redução, por meio de ações preventivas que beneficiem o trabalhador e a instituição.El estudio aborda la exposición ocupacional a material biológico a que fueron sometidos los profesionales de salud en el Hospital Santa Casa de Misericordia de Pelotas, de enero de 2004 a junio de 2008. Este es un corte transversal, descriptivo y cuantitativo. Se utiliza como herramienta de investigación un cuestionario basado en el formulario de informe de accidente de trabajo de esa institución. Los datos fueron introducidos y analizados con Epi-Info 6.04. Como principal resultado se encontró una mayor incidencia de accidentes con material biológico entre los profesionales técnicos de enfermería del sexo femenino (38,6%, de 21 años a 30 años (53,9%. La mayoría de los accidentes ocurrió a través de lesiones con objetos punzantes (82,2%, siendo que 24,1% ocurrió en el Centro Quirúrgico, y 84,5% con sangre. Se

  3. Methods and logistics of a multidisciplinary survey of schoolchildren from Pelotas, in the Southern Region of Brazil Métodos y logística de un estudio multidisciplinar con escolares de Pelotas, sur de Brasil Métodos e logística de um estudo multidisciplinar com escolares de Pelotas, Sul do Brasil

    Directory of Open Access Journals (Sweden)

    Marlos Rodrigues Domingues

    2013-05-01

    Full Text Available This paper describes the methods of a multidisciplinary epidemiological survey conducted in schools in Pelotas, in the Southern Region of Brazil. This cross-sectional study evaluated a representative sample (n = 1,211 of eight to 12-year-old children attending public (15 and private (5 schools. Questionnaires were applied to parents to obtain information about socioeconomic and sociocultural characteristics. Children were interviewed to provide information on demographic characteristics, oral health behavior and physical activity habits. Oral health examinations were performed on the children and anthropometric data was collected to assess nutritional status. School principals responded a questionnaire about the social and physical environment of the school. A total of 1,744 children were eligible for the study; a response rate of 69.4% was achieved, with no significant differences between schools. The method used allowed investigators to obtain data on several health outcomes as well as on possible risk factors. This strategy optimizes the use of financial resources for research and promotes interprofessional collaboration.El artículo detalla los métodos de un estudio epidemiológico multidisciplinar llevado a cabo en escuelas en Pelotas, sur de Brasil. El estudio transversal incluyó una muestra representativa (n = 1.211 de niños de 8 a 12 años, en escuelas públicas (15 y privadas (5. Los cuestionarios fueron administrados a los padres para obtener información socioeconómica y cultural. Los niños fueron entrevistados, proporcionando información demográfica, comportamientos de salud bucal y práctica de actividad física. Se realizaron un examen de salud bucal y medidas antropométricas para la evaluación de la condición nutricional. Directores de escuelas proporcionaron información sobre el ambiente físico y social de las escuelas. De los 1.744 niños elegibles, la tasa de respuesta fue de un 69,4% sin diferencias entre escuelas

  4. Sedentary behavior in adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil) birth cohort study.

    Science.gov (United States)

    Dumith, Samuel C; Hallal, Pedro C; Menezes, Ana M B; Araújo, Cora Luiza

    2010-10-01

    The aim of this study was to estimate the prevalence of sedentary behavior and investigate associated factors in adolescents 11 years of age from the 1993 birth cohort in Pelotas, Rio Grande do Sul State, Brazil. Sedentary behavior was investigated with a questionnaire, and was defined as spending more than two hours per day watching television, playing videogames, or using the computer. Of the 4,452 adolescents interviewed, 98% reported watching television, 44% playing videogames, and 22% using the computer. The average time spent on each of these electronic media was 197, 36, and 17 minutes per day, respectively. Prevalence of sedentary behavior was 79.7% (95%CI: 78.6; 80.9) and showed a positive association with socioeconomic level and nutritional status and a negative association with well-being. These 11-year-olds spent extensive time at TV viewing, videogames, and the computer. Special attention should be given to the most exposed groups of adolescents, including the more affluent, overweight, and those with limited schooling.

  5. COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study.

    Science.gov (United States)

    Salatino-Oliveira, Angélica; Murray, Joseph; Kieling, Christian; Genro, Júlia Pasqualini; Polanczyk, Guilherme; Anselmi, Luciana; Wehrmeister, Fernando; de Barros, Fernando C; Menezes, Ana Maria Baptista; Rohde, Luis Augusto; Hutz, Mara Helena

    2016-07-18

    Conduct problems in childhood and adolescence are significant precursors of crime and violence in young adulthood. The purpose of the current study is to test the interaction between prenatal maternal smoking and COMT Val(158)Met in conduct problems and crime in the 1993 Pelotas Birth Cohort Study. Conduct problems were assessed through the parent version of the Strengths and Difficulties Questionnaire at ages 11 and 15 years. A translated version of a confidential self-report questionnaire was used to collect criminal data at 18 years of age. Negative binomial regression analyses showed an association between prenatal maternal smoking and SDQ conduct problem scores (IRR = 1.24; 95% CI: 1.14-1.34; p gene in predicting conduct problems. Very similar results were obtained using the 15 years conduct scores and crime measure at age 18. Prenatal maternal smoking was associated with crime (IRR = 1.28; 95% CI: 1.09-1.48; p = 0.002) but neither COMT genotypes nor the possible interaction between gene and maternal smoking were significantly associated with crime. Replications of GxE findings across different social contexts are critical for testing the robustness of findings.

  6. Use of Medicines with Unknown Fetal Risk among Parturient Women from the 2004 Pelotas Birth Cohort (Brazil

    Directory of Open Access Journals (Sweden)

    Andréa Dâmaso Bertoldi

    2012-01-01

    Full Text Available Background. To estimate the exposure to medicines with unknown fetal risk during pregnancy and to analyze the maternal characteristics associated with it. Methods. A questionnaire was administered to 4,189 mothers of children belonging to the 2004 Pelotas (Brazil birth cohort study about use of any medicine during gestation. We evaluated the associations between use of medicines with unknown fetal risk and the independent variables through logistic regression models. Unknown fetal risk was defined as medicines in which studies in animals have revealed adverse effects on the fetus, and no controlled studies in women, or studies in women and animals, are available. Results. Out of the 4,189 women, 52.5% used at least one medicine from unknown fetal risk. Use of these medicines was associated with white skin color, high schooling, high income, six or more antenatal care consultations, hospital admission during pregnancy, and morbidity during gestation. Conclusion. The use of unknown fetal risk medicines is high, suggesting that their use must be addressed with caution with the aim of restricting their use to cases in which the benefits are greater than the potential risks.

  7. Transtornos mentais comuns e qualidade de vida em jovens: uma amostra populacional de Pelotas, Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Karen Jansen

    2011-03-01

    Full Text Available O objetivo foi verificar a prevalência de transtornos mentais comuns (TMC e sua associação com qualidade de vida em jovens da cidade de Pelotas, Rio Grande do Sul, Brasil. Estudo transversal de base populacional com jovens de 18 a 24 anos. A seleção amostral foi realizada por conglomerados. Para a investigação dos transtornos mentais comuns foi aplicado o Self Report Questionnaire (SRQ-20, enquanto os níveis de qualidade de vida foram mensurados por intermédio da Medical Outcomes Survey Short-form General Health Survey (SF-36. A prevalência de TMC na amostra estudada foi de 24,5% (N = 382, apresentando-se mais evidente entre as mulheres, entre aqueles que pertenciam à menor classe socioeconômica (D ou E, não estavam estudando, não estavam trabalhando, consumiram álcool e usaram tabaco pelo menos uma vez na última semana e que fizeram uso de alguma substância ilícita nos últimos três meses. Os jovens com TMC obtiveram uma menor média nos escores da SF-36 em todos os domínios de qualidade de vida avaliados. Deve-se investir em medidas preventivas de TMC no intuito de proporcionar uma melhor qualidade de vida à população.

  8. Sintomas articulares crônicos em adultos de Pelotas, Rio Grande do Sul, Brasil: prevalência e determinantes Chronic joint symptoms in adults from Pelotas, Rio Grande do Sul State, Brazil: prevalence and determinants

    Directory of Open Access Journals (Sweden)

    Vera Regina Lopes da Silva

    2009-12-01

    Full Text Available Com o objetivo de estimar a prevalência de sintomas articulares crônicos e seus determinantes, foi realizado um estudo transversal, com 2.953 adultos com 20 anos ou mais, residentes em Pelotas, Rio Grande do Sul, Brasil. Foram investigadas a presença de dor, edema ou rigidez articular, além de informações demográficas, sócio-econômicas e sobre problemas de saúde. A análise multivariável foi realizada pela regressão de Poisson. A prevalência geral de sintomas articulares crônicos foi de 36,5% (42,4% nas mulheres e 28,7% nos homens. A presença da tríade - dor, edema e rigidez articulares - foi de 14,1% e 5,5% nas mulheres e homens, respectivamente. Sintomas articulares crônicos se mostraram linearmente associados ao aumento da idade (RP: 2,9; IC95%: 2,4-3,5, do índice de massa corporal (RP: 1,6; IC95%: 1,3-2,0 e à menor escolaridade (RP: 1,5; IC95%: 1,3-1,8. Somente 6% dos homens e 18% das mulheres relataram diagnóstico médico de artrite. As prevalências gerais de limitações para atividades de vida diária e para atividades laborais, secundárias a sintomas articulares crônicos, foi de 15% e 21%, respectivamente. Os jovens e homens representam a maioria dos indivíduos com sintomas articulares crônicos subdiagnosticados.With the objective of estimating the prevalence of chronic joint symptoms and their determinants, a cross-sectional study was conducted with 2,953 adults 20 years or older in Pelotas, Rio Grande do Sul State, Brazil. Pain, swelling, and stiffness in joints were investigated, plus demographic, socioeconomic, and health-related information. Multivariate analysis was performed with Poisson regression. Overall prevalence of chronic joint symptoms was 36.5% (42.4% in women and 28.7% in men. The threefold presence of pain, swelling, and stiffness in joints was 14.1% and 5.5% in women and men, respectively. Chronic joint symptoms showed a linear association with increasing age (PR: 2.9; 95%CI: 2.4-3.5, body mass

  9. Determinants of preterm birth: Pelotas, Rio Grande do Sul State, Brazil, 2004 birth cohort Determinantes de nascimento pré-termo na coorte de nascimentos de 2004, Pelotas, Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Mariângela F. Silveira

    2010-01-01

    Full Text Available Prematurity is a leading cause of neonatal mortality and a global health problem that affects high, middle and low-income countries. Several factors may increase the risk of preterm birth. In this article, we test the hypothesis that different risk factors determine preterm birth in different income groups by investigating whether risk factors for preterm deliveries in the 2004 Pelotas (Rio Grande do Sul State, Brazil birth cohort vary among those groups. A total of 4,142 women were included in the analysis. Preterm births were equally common among women who had spontaneous vaginal deliveries as for those with induced or operative births. In the multivariate analysis the factors that remained significantly associated with preterm birth were black skin color, low education, poverty, young maternal age, primiparity, previous preterm birth, inadequacy of prenatal care and reported hypertension. In the analyses repeated after stratification by family income terciles, there was no evidence of effect modification by income and no clear difference between the socioeconomic groups. No association between cesarean section and preterm delivery was found. Further studies are required to understand the causes of the epidemic of preterm births in Brazil.A prematuridade é uma grande causa de morte neonatal e um problema de saúde global, afetando países de alta, média e baixa renda. Vários fatores podem aumentar o risco de parto pré-termo. Neste artigo, testamos a hipótese de que diferentes fatores de risco determinem o parto pré-termo em diferentes grupos de renda, investigando como fatores de risco para prematuridade na coorte de nascimentos de 2004 de Pelotas, Rio Grande do Sul, Brasil, variam entre estes grupos. Foram incluídas na análise 4.142 mulheres. Os nascimentos pretermo foram igualmente comuns entre mulheres com partos vaginais e com partos induzidos ou cesáreas. Na análise multivariada, a cor negra, baixa educação, baixa renda, idade

  10. Fatores de risco para diabetes mellitus gestacional na coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 2004 Risk factors for gestational diabetes mellitus in the birth cohort in Pelotas, Rio Grande do Sul State, Brazil, 2004

    Directory of Open Access Journals (Sweden)

    Maria Alice Souza de Oliveira Dode

    2009-05-01

    Full Text Available Consensos de diversos países referem idade, obesidade e história familiar de diabetes mellitus como fatores de risco para diabetes mellitus gestacional. Outros fatores permanecem controversos. O objetivo deste estudo foi investigar fatores associados ao diabetes mellitus gestacional entre mães dos recém-nascidos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, em 2004. Foram entrevistadas 4.243 puérperas no hospital, havendo 0,5% de recusas. O diagnóstico de diabetes mellitus gestacional foi auto-referido. A prevalência de diabetes mellitus gestacional foi 2,95% (IC95%: 2,53-3,64. Análise bruta realizada por meio de testes qui-quadrado mostrou associação direta com aumento da idade, escolaridade, nível econômico e índice de massa corporal (IMC e inversa com altura materna. Cor não branca, história familiar de diabetes mellitus, tabagismo no primeiro e segundo trimestres e atividade física antes da gestação e no primeiro trimestre mostraram-se associados. A análise ajustada hierarquizada realizada através de regressão logística mostrou associação com maior idade, cor não branca, maior escolaridade, história familiar de diabetes mellitus e maior IMC. A altura ficou no limiar da significância. Tabagismo no primeiro e segundo trimestres foi protetor.Consensus statements by various countries have reported age, obesity, and family history of diabetes mellitus as risk factors for gestational diabetes mellitus. Other factors remain controversial. The aim of this study was to investigate factors associated with gestational diabetes among mothers of newborns from the birth cohort in Pelotas, Rio Grande do Sul State, Brazil, in 2004. We interviewed 4,243 postpartum women in hospital, with a 0.5% refusal rate. Diagnosis of gestational diabetes was self-reported. Prevalence of gestational diabetes was 2.95% (95%CI: 2.53-3.64. Crude analysis using the chi-square test showed a direct association with age, schooling

  11. Os passos pedem passagem: An ethnophotography photo shoot on train stations ruins in the south of RSOs passos pedem passagem: um estudo etnográfico sobre Ruínas de estações ferroviárias no sul do RS

    Directory of Open Access Journals (Sweden)

    Ana Luiza Carvalho da Rocha

    2010-08-01

    Full Text Available This article proposes to discuss elements to compose an urban ethnography considering passerby perceptions as a study object about the urban space in which they live in and with which the ethnography establishes meaning relations. In the present description,the starting point is the ethnophotography incursion into Pelotas Train Station, in the state of Rio Grande do Sul, using images as a revealing element of the place´s context aiming to discuss the modes of perception on the urban landscape wreckage, the city itinerary production and the significance of these spaces in decomposition. As a way of poetic intensification, this study also searches for a signification exercise considering the lyrics of Vitor Ramil, a singer and composer from Pelotas. Através deste artigo propõe-se discutir elementos para a composição de uma etnografia sobre o urbano, tendo como objeto de estudo as percepções dos transeuntes sobre o espaço urbano no qual estão inseridos, e com o qual estabelecem relações de significado. Na presente descrição, toma-se como ponto de partida uma incursão etno-fotográfica à Estação Ferroviária da cidade de Pelotas, RS, utilizando a imagem como um elemento revelador do contexto do lugar, no intuito de discutir questões como os modos de percepção sobre as ruínas na paisagem urbana, a produção de itinerários sobre a cidade e a resignificação destes espaços em decomposição.

  12. Projeto de Salvamento Arqueológico da Área Urbana de Pelotas: Praça Cel. Pedro Osório, da Casa 8 e Casa 2

    Directory of Open Access Journals (Sweden)

    Fábio Vergara Cerqueira

    2012-09-01

    Full Text Available Este relatório  busca apresentar as atividades relativas ao projeto de salvamento arqueológico da Área Urbana de Pelotas, mais especificamente os trabalhos realizados na Praça Cel. Pedro Osório, Casa 8 e Casa 2, desenvolvidas no período de 2002 a 2004.PALAVRAS-CHAVE:  Arqueologia histórica  –  Pelotas oitocentista  – Patrimônio cultural

  13. PELOTAS,“CIDADE DE GAYS”: Um estudo sobre os usos políticos de uma representação

    Directory of Open Access Journals (Sweden)

    Gláucia Cavalheiro

    2012-09-01

    Full Text Available Esteartigo é um resumo da monografia apresentada para a conclusão do Curso de Pós-Graduação em Memória, Identidade e Cultura Material, do Instituto de Ciências Humanas da Universidade Federal de Pelotas, tendo como banca examinadora os professores Dra. Maria Letícia Mazzuchi Ferreira, Me. Edgar Rodrigues Barbosa (orientador e Dra. Flávia Rieth (co-orientadora, aos quais expresso meus profundos agradecimentos

  14. Freqüência das malformações múltiplas em recém-nascidos na Cidade de Pelotas, Rio Grande do Sul, Brasil, e fatores sócio-demográficos associados Frequency of multiple neonatal malformations in Pelotas, Rio Grande do Sul, Brazil, and associated socio-demographic factors

    Directory of Open Access Journals (Sweden)

    Martha Lopes Schuch de Castro

    2006-05-01

    Full Text Available Este estudo visa determinar a freqüência, correlacionar possíveis agentes causais e monitorizar a ocorrência de malformações múltiplas na população de Pelotas, Rio Grande do Sul, Brasil. Abrange todos os nascimentos ocorridos entre 1990 e 2002 nas maternidades de Pelotas, com peso superior a 500g. Para cada recém-nascido malformado (caso, tomou-se um neonato vivo (controle, pareado a ele, sem malformação e de igual sexo. Formou-se um banco de dados mediante o preenchimento dos formulários-modelo ECLAMC ­ MONITOR edição 1982, que foram tabulados pelo programa SPSS. Para a análise estatística, utilizou-se o Teste t de Student e chi2. No período em estudo nasceram 71.500 crianças. Dentre essas, 0,11% recém-nascidos apresentaram malformações múltiplas. Foram encontrados resultados significativos para o peso, gemelaridade e nascimento, a etnia dos antepassados, a idade paterna, o número de abortos e natimortos prévios. Em Pelotas, a ocorrência de recém-nascidos que apresentavam malformações ao nascer, no período do estudo, foi de 1,37%. A freqüência de recém-nascidos com malformações múltiplas é de 8,1%, predominantemente no sexo feminino e nos nascimentos ocorridos no inverno.This study aimed to estimate the frequency and to correlate the possible causal agents and monitor the occurrence of multiple neonatal malformations in Pelotas, Rio Grande do Sul, Brazil. The study included all births from 1990 to 2002 in the local maternity hospitals with birth weight > 500g. Each newborn presenting a malformation (case was assigned a live matched neonate (control without any malformation and of the same sex. A database was established by filling out the ECLAMC ­ MONITOR forms, 1982 edition, tabulated with SPSS. Statistical analysis used Student t and chi2. During the study period, 71,500 children were born, of whom 0.11% presented multiple malformations. Significant results were found for birth weight, twin births

  15. A Diphoton Resonance from Bulk RS

    CERN Document Server

    Csaki, Csaba

    2016-01-01

    Recent LHC data hints at a 750 GeV mass resonance that decays into two photons. A significant feature of this resonance is that its decays to Higges and to any other Standard Model particles are so far too low to be detected. Such a state has a compelling explanation in terms of a scalar or a pseudoscalar that is strongly coupled to vector states charged under the Standard Model gauge groups. We argue that if the state is a scalar, some form of sequestering is likely to be necessary to naturally explain the suppressed scalar-Higgs interactions. Such a scenario is readily accommodated in bulk RS with a scalar localized in the bulk away from the Higgs. Turning this around, we argue that a good way to find the elusive bulk RS model might be the search for a resonance with prominent couplings to gauge bosons.

  16. A diphoton resonance from bulk RS

    Science.gov (United States)

    Csáki, Csaba; Randall, Lisa

    2016-07-01

    Recent LHC data hinted at a 750 GeV mass resonance that decays into two photons. A significant feature of this resonance is that its decays to any other Standard Model particles would be too low to be detected so far. Such a state has a compelling explanation in terms of a scalar or a pseudoscalar that is strongly coupled to vector states charged under the Standard Model gauge groups. Such a scenario is readily accommodated in bulk RS with a scalar localized in the bulk away from but close to the Higgs. Turning this around, we argue that a good way to find the elusive bulk RS model might be the search for a resonance with prominent couplings to gauge bosons.

  17. Lepton flavour violation in the RS model

    Energy Technology Data Exchange (ETDEWEB)

    Moch, Paul; Beneke, Martin [Physik Department T31, Technische Universitaet Muenchen, 85748 Garching (Germany); Rohrwild, Juergen [Rudolf Peierls Centre for Theoretical Physics, University of Oxford, 1 Keble Road, Oxford OX1 3NP (United Kingdom)

    2015-07-01

    We consider charged lepton flavour observables in the Randall-Sundrum (RS) model with and without custodial protection.To this end, we apply a fully five dimensional (5D) framework to calculate the matching coefficients of the effective field theory at the electroweak scale. This enables us to compute predictions for the radiative decay μ → eγ as well as the decay μ → 3e and μ → e conversion in nuclei.

  18. PTK2 rs7460 and rs7843014 Polymorphisms and Exceptional Longevity: A Functional Replication Study

    Science.gov (United States)

    Fuku, Noriyuki; He, Zi-hong; Tian, Ye; Arai, Yasumichi; Abe, Yukiko; Murakami, Haruka; Miyachi, Motohiko; Yvert, Thomas; Venturini, Letizia; Santiago, Catalina; Santos-Lozano, Alejandro; Rodríguez, Gabriel; Ricevuti, Giovanni; Pareja-Galeano, Helios; Sanchis-Gomar, Fabian; Emanuele, Enzo; Hirose, Nobuyoshi; Lucia, Alejandro

    2014-01-01

    Abstract Focal adhesion is critical for cell survival. The focal adhesion kinase (FAK, or PTK2) is an important component of the human interactome and thus is a potential longevity-related protein. Here we studied the association between two PTK2 gene single-nucleotide polymorphisms (SNPs) (rs7843014, rs7460) and exceptional longevity (EL). In addition to gaining insight into their functionality by determining luciferase gene reporter activity, we studied the genotype/allele frequency of these two SNPs among three different cohorts: (1) Spanish centenarians (n=175, 100–111 years, 144 women) and healthy controls (n=355, 20–50 years, 284 women); (2) Italian centenarians (n=79, 100–104 years, 40 women) and controls (n=316, 29–50 years, 156 women); and (3) Japanese centenarians (n=742, 100–116 years, 623 women) and healthy controls (n=499, 23–59 years, 356 women). Both SNPs had functional significance, with the A allele up-regulating luciferase activity compared to the other allele (rs7460 T allele and rs7843014 C allele, respectively). The A allele of both SNPs was negatively associated with EL in the Spanish cohort (rs7460, odds ratio [OR] adjusted by sex=0.40, 95% confidence intervals [CI] 0.3, 0.6, p<0.001); rs7843014, OR=0.37, 95% CI 0.3, 0.5, p<0.001). The OR of being a centenarian if having the rs7460-TT genotype was 6.68 (95% CI 4.1, 10.8, p<0.001). The rs7843014 CC genotype was also positively associated with EL (OR=7.58, 95% CI 4.6, 12.3, p<0.001]. No association was, however, found for the Italian or Japanese cohorts. Thus, two genotypes of the FAK gene, rs7460 TT and rs7843014 CC, are possibly associated with lower gene expression and might favor the likelihood of reaching EL in the Spanish population. Further research is needed to unveil the mechanisms by which FAK expression could perhaps influence the rate of aging. PMID:24930376

  19. PADRÃO BIOMÉTRICO DOS CAVALOS DE TRAÇÃO DA CIDADE DE PELOTAS NO RIO GRANDE DO SUL

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Wayne Nogueira

    2013-06-01

    Full Text Available Many families use wagon pulled by traction horses as their means of work or supplemental income. In Pelotas, there has been a Veterinary Clinic since 2006, which provides free weekly clinical care to these horses, due to concern about their health. The objectives of this study were to evaluate and record the biometric patterns of traction horses in Pelotas. We evaluated 219 horses, 129 females and 90 males. We measured chest width (ChW, leg perimeter (LP, thoracic perimeter (TP, croup width (CrW, height (H and weight (W of the animal. Through these values, we calculated the compactness index 1 (CCI1=(W/WH/100, compactness index 2 (CCI2 = (W/[WH-1]/100 and conformation index (CFI=TP2/WH. The animals of both sexes showed the following averages: H - 1.38 ± 0.07 m; LP - 0.19 ± 0.02 cm; TP - 1.56 ± 0.10 m; ChW - 0.26 ± 0.05 cm; CrW - 0.22 ± 0.05 cm; weight - 308 ± 60 kg. Regarding the ICC1, ICC2 and ICF indices, the averages for both sexes were, respectively: 2.30; 8.39; 1.82. Accordingly, the indices obtained showed that most of the evaluated horses were inadequate to pull heavy loads and had greater ability to pull light loads or to be used as riding horses.

  20. Application of RS Codes in Decoding QR Code

    Institute of Scientific and Technical Information of China (English)

    Zhu Suxia(朱素霞); Ji Zhenzhou; Cao Zhiyan

    2003-01-01

    The QR Code is a 2-dimensional matrix code with high error correction capability. It employs RS codes to generate error correction codewords in encoding and recover errors and damages in decoding. This paper presents several QR Code's virtues, analyzes RS decoding algorithm and gives a software flow chart of decoding the QR Code with RS decoding algorithm.

  1. Trails, RS2477, rs2477 add roads, Published in 2006, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2006. It is described as 'rs2477 add...

  2. Trails, RS2477, RS2477, Published in 2008, 1:24000 (1in=2000ft) scale, Box Elder County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2008. It is described as 'RS2477'. The...

  3. Novel biosensor-based microarray assay for detecting rs8099917 and rs12979860 genotypes

    Institute of Scientific and Technical Information of China (English)

    Pei-Yuan Li; Xiao-Jun Zhou; Lan Yao; Xin-Hua Fang; Jiang-Nan Ren; Jia-Wu Song

    2012-01-01

    AIM:To evaluate a novel biosensor-based microarray (BBM) assay for detecting rs12979860 and rs8099917genotypes.METHODS:Four probes specific for rs8099917C/T or rs12979860G/T detection and three sets of quality control probes were designed,constructed and arrayed on an optical biosensor to develop a microarray assay.Two sets of primers were used in a one tube polymerase chain reaction (PCR) system to amplify two target fragments simultaneously.The biosensor microarray contained probes that had been sequenced to confirm that they included the rsS099917C/T or rs12979860G/T alleles of interest and could serve as the specific assay standards.In addition to rehybridization of four probes of known sequence,a total of 40 clinical samples collected from hepatitis C seropositive patients were also tested.The target fragments of all 40 samples were amplified in a 50 μL PCR system.Ten μL of each amplicon was tested by BBM assay,and another 40 μL was used for sequencing.The agreement of the results obtained by the two methods was tested statistically using the kappa coefficient.The sensitivity of the BBM assay was evaluated using serial dilutions of ten clinical blood samples containing 103-104 white cells/lμL.RESULTS:As shown by polyacrylamide gel electrophoresis,two target segments of the interleukin 28B-associated polymorphisms (SNPs) were successfully amplified in the one-tube PCR system.The lengths of the two amplified fragments were consistent with the known length of the target sequences,137 and 159bps.After hybridization of the PCR amplicons with the probes located on the BBM array,the signals of each allele of both the rs8099917 SNPs and rs12979860 SNPs were observed simultaneously and were clearly visible by the unaided eye.The signals were distinct from each other,could be interpreted visually,and accurately recorded using an ordinary digital camera.To evaluate the specificity of the assay,both the plasmids and clinical samples were applied to the microarray

  4. SMIM1 variants rs1175550 and rs143702418 independently modulate Vel blood group antigen expression

    Science.gov (United States)

    Christophersen, Mikael K.; Jöud, Magnus; Ajore, Ram; Vege, Sunitha; Ljungdahl, Klara W.; Westhoff, Connie M.; Olsson, Martin L.; Storry, Jill R.; Nilsson, Björn

    2017-01-01

    The Vel blood group antigen is expressed on the red blood cells of most individuals. Recently, we described that homozygosity for inactivating mutations in SMIM1 defines the rare Vel-negative phenotype. Still, Vel-positive individuals show great variability in Vel antigen expression, creating a risk for Vel blood typing errors and transfusion reactions. We fine-mapped the regulatory region located in SMIM1 intron 2 in Swedish blood donors, and observed a strong correlation between expression and rs1175550 as well as with a previously unreported tri-nucleotide insertion (rs143702418; C > CGCA). While the two variants are tightly linked in Caucasians, we separated their effects in African Americans, and found that rs1175550G and to a lesser extent rs143702418C independently increase SMIM1 and Vel antigen expression. Gel shift and luciferase assays indicate that both variants are transcriptionally active, and we identified binding of the transcription factor TAL1 as a potential mediator of the increased expression associated with rs1175550G. Our results provide insight into the regulatory logic of Vel antigen expression, and extend the set of markers for genetic Vel blood group typing. PMID:28084402

  5. Complex Bedforms and Complex Water Masses: A Case Study from the Tertiary to Present-day, Pelotas Basin, Offshore Uruguay

    Science.gov (United States)

    Thompson, P.; Badalini, G.; Wrigley, S.; Walker, R.; Argent, J.; Hernandez-Molina, J.; de Santa Ana, H.; Soto, M.; Tomasini, J.

    2015-12-01

    Contour currents are commonly associated with bedform development on modern seabeds yet there is a general paucity of published examples from the ancient record. Recently acquired 3D seismic data, covering over 13000km2 of the Pelotas Basin, offshore Uruguay, provides a unique opportunity to study the architecture and development of a variety of bedform. The data shows that, throughout the Tertiary, contour currents were the dominant control on sedimentation along the Uruguayan margin. The first evidence of contour current activity is during the Early Tertiary in the form of a major regional unconformity that, even though it was fully subaqueous, does not show any major features associated with downslope sedimentation. In the mid-slope region, the unconformity coincides with an extensive (1500km2) intra-slope scour-field orientated parallel to the slope. Individual scours are up to 40m deep, 500m wide and 3km long. Coeval with these scours are a group of coalesced basin floor scours, which run parallel to the base of slope and extend over 400km2. Individual scours exhibit an asymmetric shape - similar to giant flute marks - that are up to 150m deep, 20km wide and extend for at least 40km along slope. The development of these scoured areas shows clear evidence of two major north-flowing water masses. Directly above this regional unconformity are a series of ribbon-like bedforms that developed oblique to the slope. Individual bedforms are up to 40km in length with wavelengths of 5km and heights up to 100m. These bedforms are overlain by a set of barchan-like dunes, up to 30km in length with wavelengths of 10km. Individual dunes are in the order of 100m thick and stack to form an overall package up to 500m thick. These features show a clear change from erosion/bypass to deposition/reworking that is linked to a decrease in ocean current velocity and/ or sediment supply. The features observed suggest a complex oceanic regime was present throughout the Tertiary that

  6. 40 CFR 180.1114 - Pseudomonas fluorescens A506, Pseudomonas fluorescens 1629RS, and Pseudomonas syringae 742RS...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Pseudomonas fluorescens A506, Pseudomonas fluorescens 1629RS, and Pseudomonas syringae 742RS; exemptions from the requirement of a tolerance... Tolerances § 180.1114 Pseudomonas fluorescens A506, Pseudomonas fluorescens 1629RS, and Pseudomonas...

  7. Design of a Smart Converter RS485/RS232%一种新型RS485/RS232多路接口智能转换器的设计

    Institute of Scientific and Technical Information of China (English)

    唐武兵; 修吉平

    2007-01-01

    本文详细地介绍了RS485总线中的一个模块即如何实现RS485接口与RS232接口之间电平的智能转换,该转换器实现了一路RS485接口到四路RS232接口的智能转换,可实现数据的透明,可靠传输,且转换器形状小巧,简单实用,具有较高的实用价值.

  8. Supersymmetry of RS bulk and brane

    CERN Document Server

    Bergshoeff, E A; Van Proeyen, A; Bergshoeff, Eric; Kallosh, Renata; Proeyen, Antoine Van

    2001-01-01

    We review the construction of actions with supersymmetry on spaces with a domain wall. The latter objects act as sources inducing a jump in the gauge coupling constant. Despite these singularities, supersymmetry can be formulated, maintaining its role as a square root of translations in this singular space. The setup is designed for the application in five dimensions related to the Randall-Sundrum (RS) scenario. The space has two domain walls. We discuss the solutions of the theory with fixed scalars and full preserved supersymmetry, in which case one of the branes can be pushed to infinity, and solutions where half of the supersymmetries are preserved.

  9. Mass and Reliability System (MaRS)

    Science.gov (United States)

    Barnes, Sarah

    2016-01-01

    The Safety and Mission Assurance (S&MA) Directorate is responsible for mitigating risk, providing system safety, and lowering risk for space programs from ground to space. The S&MA is divided into 4 divisions: The Space Exploration Division (NC), the International Space Station Division (NE), the Safety & Test Operations Division (NS), and the Quality and Flight Equipment Division (NT). The interns, myself and Arun Aruljothi, will be working with the Risk & Reliability Analysis Branch under the NC Division's. The mission of this division is to identify, characterize, diminish, and communicate risk by implementing an efficient and effective assurance model. The team utilizes Reliability and Maintainability (R&M) and Probabilistic Risk Assessment (PRA) to ensure decisions concerning risks are informed, vehicles are safe and reliable, and program/project requirements are realistic and realized. This project pertains to the Orion mission, so it is geared toward a long duration Human Space Flight Program(s). For space missions, payload is a critical concept; balancing what hardware can be replaced by components verse by Orbital Replacement Units (ORU) or subassemblies is key. For this effort a database was created that combines mass and reliability data, called Mass and Reliability System or MaRS. The U.S. International Space Station (ISS) components are used as reference parts in the MaRS database. Using ISS components as a platform is beneficial because of the historical context and the environment similarities to a space flight mission. MaRS uses a combination of systems: International Space Station PART for failure data, Vehicle Master Database (VMDB) for ORU & components, Maintenance & Analysis Data Set (MADS) for operation hours and other pertinent data, & Hardware History Retrieval System (HHRS) for unit weights. MaRS is populated using a Visual Basic Application. Once populated, the excel spreadsheet is comprised of information on ISS components including

  10. 浅谈RS232和RS485串行通讯

    Institute of Scientific and Technical Information of China (English)

    吴皓月; 李旭东; 赵亮

    2016-01-01

    本文首先阐述了RS-232、RS-485串口通信产生和特点,并穿插着比较了两种接口的差别和异同,然后实现他们之间的相互转换方法,最后又对常见的串口通讯接口I2C、CAN、SPI、USB等进行了简介。

  11. RS232/USB转换器的设计%Design Of An RS232 USB Transducer

    Institute of Scientific and Technical Information of China (English)

    陈心浩

    2003-01-01

    USB接口的外设逐步取代传统的RS232接口的外设,是当今计算机外设接口的发展趋势之一.FT8U232AM芯片可以很好地解决传统RS232接口与USB接口间协议转换的问题.文章介绍了FT8U232AM的工作原理、引脚功能以及典型电路.

  12. High-Speed RaPToRS

    Science.gov (United States)

    Henchen, Robert; Esham, Benjamin; Becker, William; Pogozelski, Edward; Padalino, Stephen; Sangster, Thomas; Glebov, Vladimir

    2008-11-01

    The High-Speed Rapid Pneumatic Transport of Radioactive Samples (HS-RaPToRS) system, designed to quickly and safely move radioactive materials, was assembled and tested at the Mercury facility of the Naval Research Laboratory (NRL) in Washington D.C. A sample, which is placed inside a four-inch-diameter carrier, is activated before being transported through a PVC tube via airflow. The carrier travels from the reaction chamber to the end station where it pneumatically brakes prior to the gate. A magnetic latch releases the gate when the carrier arrives and comes to rest. The airflow, optical carrier-monitoring devices, and end gate are controlled manually or automatically with LabView software. The installation and testing of the RaPToRS system at NRL was successfully completed with transport times of less than 3 seconds. The speed of the carrier averaged 16 m/s. Prospective facilities for similar systems include the Laboratory for Laser Energetics and the National Ignition Facility.

  13. Enhancing Route Maintenance in RS-AODV

    Directory of Open Access Journals (Sweden)

    Gaurav J. Bhatt*,

    2014-05-01

    Full Text Available Mobile Ad hoc Networks (MANETs are temporary formed, infrastructure-less networks. The performance metrics degrades due to the unstable channel conditions, network connectivity, and mobility and resource limitations. To improve different performance metrics, various cross-layering techniques are used where different layers from protocol stack communications with each other via exchange of information. Ad hoc on demand Routing Protocol (AODV is a well reactive ad hoc routing protocol. We proposed RS-AODV (Route Stability based AODV, a modified version of AODV routing protocol, based on route discovery by utilizing Physical Layer information instead of the minimum hop count approach of the default distance vector algorithm. Our research will also elaborate how the proposed model uses the received Signal Strength (RSSI to find its route. We will focus on parameters like traffic throughput, response, time, packet loss, delay, link stability, optimal usage of battery resource to increase overall lifetime of a network. And also use novel approach "make before break" that starts finding alternate route when it seems link failure due to mobility of node. Simulation results show that RS-AODV has performance better that AODV routing protocol in terms of the metrics: End-to-End delay, Packet Delivery Ratio, Network Routing Load and number of route repairs.

  14. Prevalência de insegurança alimentar em Pelotas, Rio Grande do Sul, Brasil, e estado nutricional de indivíduos que vivem nessa condição Prevalence of food insecurity in Pelotas, Rio Grande do Sul State, Brazil, and associated nutritional status

    Directory of Open Access Journals (Sweden)

    Janaína Vieira dos Santos

    2010-01-01

    Full Text Available Um estudo transversal de base populacional foi realizado em Pelotas, Sul do Brasil, para determinar a prevalência de insegurança alimentar, além de descrever o estado nutricional dos membros das famílias que vivem nessa condição. A amostra incluiu 1.450 domicílios da área urbana de Pelotas. Nessas famílias, foi aplicada uma versão curta da Escala de Segurança Alimentar (United States Department of Agriculture - seis questões aplicadas ao responsável pela alimentação no domicílio referente aos 12 meses anteriores à entrevista. Se o domicílio foi classificado como inseguro, todos os membros foram pesados e medidos. A prevalência de insegurança alimentar para todas as famílias foi de 11% (IC95%: 9-13. Nas famílias que vivem em insegurança coexistem por um lado, o excesso de peso e obesidade entre as crianças e os adultos e, por outro, uma prevalência substancial de déficit de crescimento entre as crianças (21%. Conclui-se que esse estado de insegurança alimentar pode estar relacionado não somente à diminuição da quantidade de alimentos como à perda da qualidade nutritiva.A population-based cross-sectional study was conducted in Pelotas, Southern Brazil, to assess the prevalence of food insecurity and describe the nutritional status of family members living in this condition. The sample included 1,450 households from the urban area of Pelotas. The six questions of the Food Insecurity Scale (United States Department of Agriculture were administered to the person in charge of preparing meals in the house. A 12-month recall period was used. If the household was considered insecure, all members were weighed and measured. Prevalence of food insecurity for all families was 11% (95%CI: 9%-13%. In families living in food insecurity, overweight and obesity were frequent; meanwhile, 21% of the children showed height deficit. The authors conclude that food insecurity results not only from quantitative limitations but also from

  15. Vinte e quatro meses de heterocontrole da fluoretação das águas de abastecimento público de Pelotas, Rio Grande do Sul, Brasil Twenty-four months of external control of fluoride levels in the public water supply in Pelotas, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Fábio Garcia Lima

    2004-04-01

    Full Text Available O objetivo deste estudo foi monitorar, mensalmente, os níveis de flúor na água de abastecimento público de Pelotas, Rio Grande do Sul, Brasil, bem como verificar a validade da formação de grupos de heterocontrole. Pelotas foi dividida em 16 pontos geográficos, incluindo as três Estações de Tratamento da água e a coleta foi feita de novembro de 1999 a outubro de 2001, em duplicata. Após a coleta, as amostras foram enviadas ao Laboratório de Vigilância Sanitária de Flúor da Universidade do Vale do Itajaí, onde a análise foi feita utilizando-se o método eletrométrico (Orion 920A/Eletrodo Orion 9609. Após 24 meses, 764 unidades amostrais foram coletadas e verificou-se uma inconstância nos resultados, predominando níveis insuficientes de flúor até o primeiro trimestre de 2001, quando houve um significativo aumento no número de unidades amostrais com uma concentração de flúor ideal (0,6-0,9ppmF, porém, há o surgimento de pontos revelando um excesso de fluoretos (> 1ppmF. Os resultados permitiram concluir que o heterocontrole é fundamental para buscar a manutenção de um correto programa de FAAP.The aim of the present study was monthly evaluation of fluoride levels in the public water supply in Pelotas, Rio Grande do Sul State, Brazil, and the validity of forming external control groups. Pelotas was divided into 16 geographic regions, including the three public water treatment stations. Water samples were collected from November 1999 to October 2001. Two samples were drawn from each region. Samples were sent to the Fluoride Health Surveillance Laboratory at Universidade do Vale do Itajaí. Fluoride analysis used an electrometric method (Orion 920 A/Electrometer Orion 9609. After 24 months, 764 samples were collected, demonstrating a discontinuity in the fluoride levels. There was an increase in the number of samples with an ideal concentration of fluoride. However, several points with excessive fluoride levels (> 0.9ppm

  16. Design of USB 、RS232/RS422 interface convertion circuit%USB、RS232/S422接口转换电路的设计

    Institute of Scientific and Technical Information of China (English)

    黄燕妮; 王少云

    2012-01-01

    由于USB接口正逐步替代传统的RS232接口成为PC机的标准接口,USB接口转换电路的设计就很有必要。采用Silicon公司高集成度的USB—UART桥接器件CP2102,辅以简单的外部电路,实现了RS232/RS422接口与USB接口转换电路的设计。其中在详细介绍CP2102结构和特性的基础上,给出了接口转换的硬件电路图,最后简单介绍了转换器的工作原理。%Due to USB(Universal Serial Bus) interface is gradually replacing the traditional RS232 interface,and becoming the PC standard interface, the conversion circuit of USB,RS232 / RS422 interface is important and necessary. Using Silicon's CP2102 which is highly-integrated USB to UART bridge device, the paper provides USB interface convertion with a simple external circuit. On the basis of introducting the feature and structure of CP2102, the paper gives how to design hardware circuit of USB ,RS232 / RS422 interface conversion and how to use it.

  17. Raleio de gemas florais para a redução do abortamento em pereira (Pyrus pyrifolia na região de Pelotas-RS Bud flower thinning on the reduction of abortion in pear (Pyrus pyrifolia in Pelotas region

    Directory of Open Access Journals (Sweden)

    Renato Trevisan

    2005-12-01

    Full Text Available No Brasil, a exploração comercial da cultura da pereira tem pouca expressão, devido à baixa produtividade das plantas, sendo o consumo interno abastecido pelas importações. A falta de adaptação das cultivares e o abortamento de gemas florais são os principais problemas para o seu desenvolvimento. Este trabalho teve como objetivo avaliar o efeito do raleio de gemas florais na redução do abortamento, nas cultivares asiáticas Nijisseiki e Shinseiki. As observações foram realizadas em três períodos: no início do inverno (junho, no início da primavera (setembro e na primavera (novembro de 2003. O experimento foi conduzido em blocos ao acaso, com três repetições, sendo o abortamento de gemas a variável avaliada. Embora o raleio de gemas não tenha diminuído os índices de abortamento nas cultivares, devem ser feitos novos estudos, podendo, desta forma, constituir-se numa prática cultural, para tentar reduzir o abortamento de gemas florais que se intensifica no inverno e início da primavera, em regiões onde o frio acumulado no inverno é insuficiente.The commercial exploration of the pear culture in Brazil has little expression, due to the low productivity of the plants, being the internal consumption supplied by imports. The lack of adaptation and flower bud abortion, are the main problems for the development of this crop. This work had the objective to evaluate the effect of flower buds thinning on the reduction of the abortion, in Asian cultivars Nijisseiki and Shinseiki. Flower abortion was evaluated at three different times: beginning of the winter (June, spring (September and end of spring (November during the year of 2003. The experiment was carried out in a randomized block design with three replicates. The parameter evaluated was the percentage of flower bud abortion. Although the bud thinning has not reduced the abortion indexes in the cultivars, new studies will must be done, being able to, constitute in a cultural practice, trying to reduce the bud floral abortion which intensifies in the winter and in the beginning of the spring, in areas where the chilling hours is insufficient.

  18. Cultura Emprendedora y Televisión: #PuntoPelota24h. El formato televisivo que revolucionó los Madrid- Barça

    OpenAIRE

    Dionis Sevilla, Juan

    2014-01-01

    Proyecto Fin de Grado leído en la Universidad Rey Juan Carlos en el curso académico 2013/2014. Director: Juan Jesús Menor Sendra 'Punto Pelota' se ha convertido en un fenómeno social, respaldado por una audiencia fiel y numerosa y posee un formato que, pese a las críticas, es ejemplo de innovación, creatividad y éxito televisivo. Este trabajo pretende desgranar cómo el Maratón del programa, coincidente con el Clásico del fútbol español, ha marcado un antes y un después en la fo...

  19. Evaluación y caracterización biomecánica de los trinquetes de pelota valenciana. (Biomechanical assessment and characterization of the Valencian ball trinquetes.

    Directory of Open Access Journals (Sweden)

    Ana María Montaner Sesmero

    2012-01-01

    Full Text Available The trinquete is the reference facility in the practice of Valencian ball game, where professionals play escala i corda and raspall. However, there is not a standard or specific test procedures to determine the mechanical characteristics of walls and surface in order to obtain a safety practice and high performance for players. The aim of this survey was to explain the test procedures, to analyze different mechanical variables in the game facilities and to establish the quality mechanical values. Friction and bounce ball tests were performed in 10 trinquetes of Valencian Community, separated into two groups in function of their quality. The results show that exist mechanical significant differences (p ResumenEl trinquete es la instalación de referencia en la práctica de la pelota valenciana, donde se juegan las modalidades profesionales de escala i corda y raspall. Sin embargo, no existe una normativa ni procedimientos de ensayo específicos que permitan definir las características mecánicas que deben reunir paredes y pavimento del trinquete, para que los jugadores tengan una práctica segura y optimicen su rendimiento. El objetivo de este estudio fue analizar diferentes variables mecánicas en las instalaciones de juego, determinar los procedimientos de ensayo más adecuados y, finalmente, proponer unos valores mecánicos que definan una instalación de calidad. Los estudios se llevaron a cabo en 10 trinquetes de la Comunidad Valenciana. Se realizaron ensayos de fricción y de bote de pelota. Los resultados revelan que existen diferencias significativas (p

  20. El desarrollo de la investigación sobre pelota valenciana: guía bibliográfica y fuentes de información

    Directory of Open Access Journals (Sweden)

    Gregorio González Alcaide

    2016-03-01

    Full Text Available Se presenta un estudio bibliográfico de los trabajos académicos sobre Pelota Valenciana, efectuado a partir de la consulta de las fuentes documentales de la Federació de Pilota Valenciana, del Museu de la Pilota de Genovés y de diversos catálogos y bases de datos. Se han identificado 181 trabajos, entre artículos de revistas (n = 95, publicaciones monográficas (n = 40, comunicaciones a congresos (n=37, tesis doctorales (n = 5 y obras de referencia (n = 4. Los trabajos pioneros se remontan a los años 60 y 70 del siglo xx, mientras que se observa una gran eclosión de publicaciones a partir de mediados de la década de los 80, en una tendencia que se mantiene hasta la actualidad, y que coincide con la edición de revistas especializadas, con la celebración de diferentes congresos y reuniones científicas y con la lectura de algunas tesis doctorales. Entre las materias abordadas en los trabajos, encontramos estudios históricos sobre su origen y desarrollo, investigaciones centradas en los espacios físicos en que tiene lugar el juego, en las distintas modalidades, en el vocabulario, que estudian el interés y la importancia que tiene para el ámbito educativo, análisis sociológicos y estudios médicos sobre las enfermedades relacionadas con la práctica de la pelota como actividad deportiva.

  1. Vinte e quatro meses de heterocontrole da fluoretação das águas de abastecimento público de Pelotas, Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Fábio Garcia Lima

    Full Text Available O objetivo deste estudo foi monitorar, mensalmente, os níveis de flúor na água de abastecimento público de Pelotas, Rio Grande do Sul, Brasil, bem como verificar a validade da formação de grupos de heterocontrole. Pelotas foi dividida em 16 pontos geográficos, incluindo as três Estações de Tratamento da água e a coleta foi feita de novembro de 1999 a outubro de 2001, em duplicata. Após a coleta, as amostras foram enviadas ao Laboratório de Vigilância Sanitária de Flúor da Universidade do Vale do Itajaí, onde a análise foi feita utilizando-se o método eletrométrico (Orion 920A/Eletrodo Orion 9609. Após 24 meses, 764 unidades amostrais foram coletadas e verificou-se uma inconstância nos resultados, predominando níveis insuficientes de flúor até o primeiro trimestre de 2001, quando houve um significativo aumento no número de unidades amostrais com uma concentração de flúor ideal (0,6-0,9ppmF, porém, há o surgimento de pontos revelando um excesso de fluoretos (> 1ppmF. Os resultados permitiram concluir que o heterocontrole é fundamental para buscar a manutenção de um correto programa de FAAP.

  2. Maternidade na adolescência : efeitos a curto e longo prazo sobre a saúde e o capital humano dos filhos. Coortes de Nascimentos de Pelotas, RS - 1982, 1993 e 2004

    OpenAIRE

    MÉNDEZ, María Clara Restrepo

    2012-01-01

    Embora as taxas de fecundidade na adolescência estejam diminuindo, a maternidade na adolescência mantém sua visibilidade como fenômeno social que necessita especial atenção de gestores públicos e pesquisadores. Muitos estudos sugerem que ser mãe na adolescência tem efeitos deletérios para a saúde da própria mãe e para seu filho nos primeiros anos de vida. Outros autores apontam para efeitos adversos a longo prazo, porém, a literatura neste sentido é limitada, particularmente em países de rend...

  3. Characterization of RsMYB28 and RsMYB29 transcription factor genes in radish (Raphanus sativus L.).

    Science.gov (United States)

    Luo, X B; Liu, Z; Xu, L; Wang, Y; Zhu, X W; Zhang, W; Chen, W; Zhu, Y L; Su, X J; Everlyne, M; Liu, L W

    2016-09-23

    Glucosinolates (GSLs) are important secondary metabolites in Brassicaceae plants. Previous studies have mainly focused on GSL contents, types, and biosynthesis-related genes, but the molecular characterization patterns of GSL biosynthesis-related transcription factors remain largely unexplored in radish (Raphanus sativus L.). To isolate transcription factor genes regulating the GSL biosynthesis, genomic DNA and cDNA sequences of RsMYB28 and RsMYB29 genes were isolated in radish. Two R2R3-MYB domains were identified in the deduced amino acid sequences. Subcellular localization and yeast-one hybrid assays indicated that both the RsMYB28 and RsMYB29 genes were located in the nucleus and possessed transactivation activity. Reverse transcription quantitative analysis showed that the RsMYB28 and RsMYB29 genes were expressed in seeds, leaves, stems, and roots at the seedling, taproot thickening, and mature stages. Both genes were highly expressed during the seedling and taproot thickening stages. The expression level of RsMYB28 was found to be up-regulated following wounding, glucose, and abscisic acid treatments, whereas RsMYB29 was up-regulated following wounding and methyl jasmonate treatments. These results provide insights into the biological function and characterization of the RsMYB28 and RsMYB29 genes, and facilitate further dissection of the molecular regulatory mechanism underlying the GSL biosynthesis in radish.

  4. 一种实用的串行通信RS232/RS485转换器%A Sort of Applied Serial Communication Switch of RS232/RS485

    Institute of Scientific and Technical Information of China (English)

    陈铁军

    2001-01-01

    本文介绍了一种RS485接口芯片SN75LBC184,并给出了一种低成本、带光电隔离的RS232/RS485转换器的设计.经现场使用表明,该转换器结构简单,工作可靠,能满足大部分工业现场的要求.

  5. High pressure intensification of cassava resistant starch (RS3) yields

    OpenAIRE

    2015-01-01

    Cassava starch, typically, has resistant starch type 3 (RS3) content of 2.4%. This paper shows that the RS3 yields can be substantially enhanced by debranching cassava starch using pullulanase followed by high pressure or cyclic high-pressure annealing. RS3 yield of 41.3% was obtained when annealing was carried out at 400 MPa/60°C for 15 min, whereas it took nearly 8 h to obtain the same yield under conventional atmospheric annealing at 60°C. The yield of RS3 could be further significantly in...

  6. 基于RS232-CAN和RS232-USB协议模块的设计

    Institute of Scientific and Technical Information of China (English)

    郭耀泉; 吴淑娟; 陈永汉

    2011-01-01

    本文针对计算机与多个控制器构成的控制系统,提出了一种基于USB-RS232和CAN-RS232协议转换模块的多主通讯模式,与传统的基于RS232和RS485的主从通讯方式相比,不仅提高了通讯速度与效率,而且还提高了通讯的可靠性和稳定性。然后,从软硬件两个方面对所设计的USB-RS232和CAN-RS232协议转换模块进行详细的介绍。

  7. Association analysis of APOA5 rs662799 and rs3135506 polymorphisms with obesity in Moroccan patients.

    Science.gov (United States)

    Lakbakbi El Yaagoubi, F; Charoute, H; Bakhchane, A; Ajjemami, M; Benrahma, H; Errouagui, A; Kandil, M; Rouba, H; Barakat, A

    2015-12-01

    The aim of the present study is to explore the association between the APOA5 polymorphisms and haplotypes with obesity in Moroccan patients. The study was performed in 459 subjects, Obese (n=164) and non-obese (n=295). All subjects were genotyped for the APOA5 -1131T>C (rs662799) and c.56C>G (rs3135506) polymorphisms. The contribution of APOA5 polymorphisms and haplotypes in the increased risk of obesity were explored using logistic regression analyses. The -1131T>C and c.56C>G polymorphisms were significantly associated with obesity. Both polymorphisms were strongly associated with increased BMI. Analysis of constructed haplotypes showed a significant association between CG haplotype and susceptibility to obesity (OR [95%CI]=3.09 [1.93-4.97]; Pobesity.

  8. The 3Rs principle – mind the ethical gap!

    DEFF Research Database (Denmark)

    Olsson, I. Anna S.; Franco, Nuno H.; Weary, Daniel M.;

    2012-01-01

    Over the 50 years since they were first proposed, the 3Rs (Replacement, Reduction, Refinement) have made a tremendous impact. These principles seem to unify concerns for better science with causing less harm to animals. The ideas behind the 3Rs are so intuitively compelling that it is tempting...

  9. Radio emission from RS CVn binary systems

    Energy Technology Data Exchange (ETDEWEB)

    Doiron, D.J.

    1984-01-01

    The RS CVn binary stellar systems UX Ari, HR 1099, AR Lac, HR 5110, II Peg, lambda And, and SZ Psc were investigated by use of radio interferometry during the period from July 1982 through August 1983. Interferometry took two forms: Very Large Array (VLA) observations and Very Long Baseline Interferometry (VLBI). The VLA observations determined the characteristic polarization and flux behavior of the centimeter wavelength radio emission. The observed spectral index was near zero during quiescent periods, rising to between 0.5 and 1.0 during active periods. No net linear polarization is observed to a limit of 1.7%. This is expected since the Faraday depth of thermal electrons deduced from x-ray observations is approx. 10/sup 5/. Circular polarization is observed to be less than 20% at all frequencies often with a helicity reversal between 1.6 GHz and 5 GHz. The VLBI observations have shown that the brightness temperatures are often T/sub B/ approx.> 10/sup 10/ /sup 0/K and size sources smaller than or comparable to the overall size of the binary system. These data are consistent with incoherent gyrosynchrotron emission from mildly relativistic electrons which are optically thick to their own radiation at 1.6 GHz and optically thin at 5 GHz and above. The spectral behavior suggests that the radio emission is due to a power-law distribution of electrons.

  10. 大米及其制品中的RS3%RS3 contents in rice and rice products

    Institute of Scientific and Technical Information of China (English)

    谢天

    2011-01-01

    测定了英国市场上销售的Basmati(白米,糙米)(长粒米),泰国香米(长粒米),日本大米(短粒米)样品中RS3的含量,比较长粒米和短粒米在熟化过程的稳定性以及不同米制品中含量的差异.结果表明,短粒大米RS3含量高于长粒大米;熟化过程对RS3含量的影响巨大,其中白米米粉在熟化过程中RS3含量下降的程度低于糙米米粉,长粒米米粉、短粒米米粉在熟化过程中RS3含量下降的程度差异不大;保鲜米饭与同品种大米制作熟化大米粉的RS3含量基本相当.%Nine rice samples from British markets were used for measuring the RS3 content. The cooking stability of long grain and short grain was compared, as well as the content in different rice products. From the result, short grain rice had higher RS3 content compared to long grain rice. Cooking treatment strongly influenced RS3 content in all samples. The decreasing rate of RS3 content in brown rice powder was less than white rice powder. There was no big defference between short grain and long grain. Ready to eat cooked rice had similar RS3 content with freshly cooked white rice powder.

  11. Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China.

    Science.gov (United States)

    Gao, Kaiping; Wang, Jinjin; Li, Linlin; Zhai, Yujia; Ren, Yongcheng; You, Haifei; Wang, Bingyuan; Wu, Xuli; Li, Jianna; Liu, Zichen; Li, Xiong; Huang, Yaxin; Luo, Xin-Ping; Hu, Dongsheng; Ohno, Kinji; Wang, Chongjian

    2016-02-26

    Genetic variants at KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963 have been associated with type 2 diabetes mellitus (T2DM), but the results are contradictory in Chinese populations. The aim of the present study was to investigate the association of these four SNPs with T2DM in a large population of Han Chinese at Henan province, China. Seven-hundred-thirty-six patients with T2DM (cases) and Seven-hundred-sixty-eight healthy glucose-tolerant controls were genotyped for KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963. The association of genetic variants in these four genes with T2DM was analyzed using multivariate logistic regression. Genotypes and allele distributions of KCNQ1 rs151290 were significantly different between the cases and controls (p 290 in KCNQ1 were associated with increases risk of T2DM before (OR = 1.482, 95% CI = 1.062-2.069; p = 0.021; OR = 1.544, 95% CI = 1.097-2.172, p = 0.013; and OR = 1.509, 95% CI = 1.097-2.077, p = 0.011, respectively) and after (OR = 1.539, 95% CI = 1.015-2.332, p = 0.042; OR = 1.641, 95% CI = 1.070-2.516, p = 0.023; and OR = 1.582, 95% CI = 1.061-2.358, p = 0.024; respectively) adjustment for sex, age, anthropometric measurements, biochemical indexes, smoking and alcohol consumption. Consistent with results of genotype analysis, the C allele of rs151290 in KCNQ1 was also associated with increased risk of T2DM (OR = 1.166, 95% CI = 1.004-1.355, p = 0.045). No associations between genetic variants of KLF14 rs972283, GCKR rs780094 or MTNR1B rs10830963 and T2DM were detected. The AC and CC genotypes and the C allele of rs151290 in KCNQ1 may be risk factors for T2DM in Han Chinese in Henan province.

  12. RS485 Image Sensor for Digital Cinema System

    Directory of Open Access Journals (Sweden)

    Eunju Kim

    2016-01-01

    Full Text Available To activate various devices using RS485, a repeater is generally used. In current digital cinema systems, each device is controlled with RS485 by mixing RS485 and DMX512. However, as today’s cinema equips hundreds of 4D chairs and the environmental directors, it is nearly infeasible for the legacy system to control. To this end, this paper designs and implements a new system which makes hundreds of 4D chairs and the environmental directors be controlled simultaneously exploiting RS485 network topology and its repeaters. The proposed approach is tested in a real-time system for assessing the performance by Paessler Router Traffic Grapher (PRTG in Windows environment. Simulation results show that the tested system supports 4D chairs and their motions are well operated simultaneously with RS485.

  13. 奥迪跑车RS6 Plus

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    奥迪最猛的跑车原来是RS6,但现在已被其加强型版RS6 Plus所取代,拥有480马力 的RS6 Plus比现行的RS6多出60马力,最大扭矩区也从1950~5600rpm扩展到1950~6000rpm。RS6 Plus性能超群,0-100km/h只需4.6秒,0-200km/h也只要17.3秒,最高车速在电子限速下达到280km/h。

  14. High pressure intensification of cassava resistant starch (RS3) yields.

    Science.gov (United States)

    Lertwanawatana, Proyphon; Frazier, Richard A; Niranjan, Keshavan

    2015-08-15

    Cassava starch, typically, has resistant starch type 3 (RS3) content of 2.4%. This paper shows that the RS3 yields can be substantially enhanced by debranching cassava starch using pullulanase followed by high pressure or cyclic high-pressure annealing. RS3 yield of 41.3% was obtained when annealing was carried out at 400MPa/60°C for 15 min, whereas it took nearly 8h to obtain the same yield under conventional atmospheric annealing at 60°C. The yield of RS3 could be further significantly increased by annealing under 400 MPa/60°C pressure for 15 min followed by resting at atmospheric pressure for 3h 45 min, and repeating this cycle for up to six times. Microstructural surface analysis of the product under a scanning electron microscope showed an increasingly rigid density of the crystalline structure formed, confirming higher RS3 content.

  15. Association between MYO9B rs962917 and rs1545620 gene polymorphism and clinical characteristic of inflammatory bowel disease

    Institute of Scientific and Technical Information of China (English)

    黄健

    2014-01-01

    Objective To investigate the association between MYO9B rs962917 and rs1545620 gene polymorphism and clinical pathological characteristics of patients with inflammatory bowel disease(IBD)and permeability of intestinal mucosa.Methods From September 2010 to May2012,a total of 196 cases of patients with IBD were collected,

  16. Characterization of surfacing on exteriors and identification of pathologies in San Francisco de Paula (Pelotas/Rio Grande del Sud, Brasil

    Directory of Open Access Journals (Sweden)

    Oliveira, Mário M.

    2009-08-01

    Full Text Available San Francisco de Paula Cathedral, a nineteenth century neoclassical building, epitomizes the ballooning population and thriving economy that prevailed in Brazil at the time. Ever since its construction in 1813 under an initiative of Felício da Costa Pereira and donor Antonio Francisco de los Ángeles (Almanaque Pelotas, 1914; p. 176, it underwent enlargements, changes and remodelling. It acquired its present appearance in 1948, when the outside walls were surfaced with a blend of cement, sand and isinglass, locally known as “combed cement”. That surfacing is presently in the process of maintenance and restoration. In light of the scant and incipient literature on the subject, a study was conducted prior to rehabilitation to analyze the construction system used in the building, characterize the surfacing both physically and chemically, and identify visible pathologies.La catedral de San Francisco de Paula es un edificio en el estilo neo-renacentista, construido en el siglo XIX, que bien representa el exuberante crecimiento poblacional y económico de la época. Su edificio, que fue construido en 1813, por iniciativa del vicario Felício da Costa Pereira y del donatario de la capitanía Antonio Francisco de los Ángeles (Almanaque Pelotas, 1914; p. 176, sufrió ampliaciones, modificaciones y reformas hasta asumir su forma y apariencia definitiva, en 1948, con la aplicación en las paredes externas de un revestimiento de cemento, arena y mica, conocido en la región como cemento peinado. Actualmente, la catedral se encuentra en etapa de mantenimiento y recuperación del referido revestimiento. Teniendo en cuenta que las investigaciones bibliográficas sobre este tipo de revestimiento son incipientes, lo que dificulta su mantenimiento, se llevó a cabo un estudio inicial para su recuperación. Para esto, se hizo el análisis de la construcción del edificio, la caracterización química y física del revestimiento y la identificación de fen

  17. Association between RAD 51 rs1801320 and susceptibility to glioblastoma.

    Science.gov (United States)

    Franceschi, S; Tomei, S; Mazzanti, C M; Lessi, F; Aretini, P; La Ferla, M; De Gregorio, V; Pasqualetti, F; Zavaglia, K; Bevilacqua, G; Naccarato, A G

    2016-01-01

    Glioblastoma is the most common and aggressive malignant primary brain tumor. Despite decades of research and the advent of new therapies, patients with glioblastoma continue to have a very poor prognosis. Radiation therapy has a major role as adjuvant treatment for glioblastoma following surgical resection. Many studies have shown that polymorphisms of genes involved in pathways of DNA repair may affect the sensitivity of the cells to treatment. Although the role of these polymorphisms has been investigated in relation to response to radiotherapy, their role as predisposing factors to glioblastoma has not been clarified yet. In the present study, we evaluated the association between polymorphisms in DNA repair genes, namely: XRCC1 rs25487, XRCC3 rs861539 and RAD51 rs1801320, with the susceptibility to develop glioblastoma. Eighty-five glioblastoma patients and 70 matched controls were recruited for this study. Data from the 1000 Genomes Project (98 Tuscans) were also downloaded and used for the association analysis. Subjects carrying RAD51 rs1801320 GC genotype showed an increased risk of glioblastoma (GC vs GG, χ(2) = 10.75; OR 3.0087; p = 0.0010). The C allele was also significantly associated to glioblastoma (χ(2) = 8.66; OR 2.5674; p = 0.0032). Moreover, RAD51 rs1801320 C allele increased the risk to develop glioblastoma also when combined to XRCC1 rs25487 G allele and XRCC3 rs861539 C allele (χ(2) = 6.558; p = 0.0053).

  18. Enantioselective degradation of (2RS,3RS)-paclobutrazol in peach and mandarin under field conditions.

    Science.gov (United States)

    Wang, Xiangyun; Qi, Peipei; Yang, Guiling; Wang, Xinquan; Zhang, Hu; Xu, Hao; Wang, Zhiwei; Wang, Qiang

    2014-08-01

    In this study we investigated the enantioselective degradation of (2RS,3RS)-paclobutrazol in peach and mandarin fruits under field conditions after foliar treatment at 500 mg active ingredient/L using a Lux Cellulose-1 chiral column on a reverse-phase liquid chromatography-tandem mass spectrometry system. Degradations of paclobutrazol in both fruits followed first-order kinetics, with half-lives of about 9 days. Initial deposits were 1.63 mg/kg on peach and 1.99 mg/kg on mandarin; terminal concentrations were lower than 0.05 mg/kg, which was acceptable in most cases. As anticipated, paclobutrazol levels in peels of mature mandarin were about 6.3 times higher than in pulp, indicating the potential risk of peel consumption. We also observed that paclobutrazol degradation in mature mandarin was relatively slow, indicating it might not be efficient enough to hold mandarin fruits on trees for lowering paclobutrazol concentrations. Significant enantioselectivity was observed: the (2R,3R)-enantiomer was preferentially degraded in mandarin (whole fruit, peels, and pulp) but enriched in peach. Because of its more rapid degradation in mandarin and the lower levels observed in pulp compared with peels, potential endocrine-related side effects due to the (2R,3R)-enantiomer pose less of a risk in mandarin than in peach.

  19. Interleukin-10 rs2227307 and CXCR2 rs1126579 polymorphisms modulate the predisposition to septic shock

    Directory of Open Access Journals (Sweden)

    Cristina Padre Cardoso

    2015-06-01

    Full Text Available Despite major improvements in its treatment and diagnosis, sepsis is still a leading cause of death and admittance to the intensive care unit (ICU. Failure to identify patients at high risk of developing septic shock contributes to an increase in the sepsis burden and rapid molecular tests are currently the most promising avenue to aid in patient risk determination and therapeutic anticipation. The primary goal of this study was to evaluate the genetic susceptibility that affects sepsis outcome in 72 sepsis patients admitted to the ICU. Seven polymorphisms were genotyped in key inflammatory response genes in sepsis, including tumour necrosis factor-α, interlelukin (IL-1β, IL-10, IL-8, Toll-like receptor 4, CXCR1 and CXCR2. The primary finding showed that patients who were homozygous for the major A allele in IL-10 rs1800896 had almost five times higher chance to develop septic shock compared to heterozygotes. Similarly, selected clinical features and CXCR2 rs1126579 single nucleotide polymorphisms modulated septic shock susceptibility without affecting survival. These data support the hypothesis that molecular testing has clinical usefulness to improve sepsis prognostic models. Therefore, enrichment of the ICU portfolio by including these biomarkers will aid in the early identification of sepsis patients who may develop septic shock.

  20. Design and implementation of a fiber optic RS232 link

    Science.gov (United States)

    Ryan, James W.

    1987-09-01

    This thesis investigates the feasibility of using a bi-directional fiber optic link to implement a RS232 data link. The results showed that a fiber optic link is a viable replacement. It offers a bandwidth up to 5 MHz, 250 times that of a RS232 data link. This fiber optic link was tested over a distance of 1.5 kilometers, nearly 100 times that of the present RS232 link. It also offers the benefits of space and weight savings and is comparable to devices produced commercially but at a substantial cost savings.

  1. RS-34 Phoenix (Peacekeeper Post Boost Propulsion System) Utilization Study

    Science.gov (United States)

    Esther, Elizabeth A.; Kos, Larry; Burnside, Christopher G.; Bruno, Cy

    2013-01-01

    The Advanced Concepts Office (ACO) at the NASA Marshall Space Flight Center (MSFC) in conjunction with Pratt & Whitney Rocketdyne conducted a study to evaluate potential in-space applications for the Rocketdyne produced RS-34 propulsion system. The existing RS-34 propulsion system is a remaining asset from the de-commissioned United States Air Force Peacekeeper ICBM program, specifically the pressure-fed storable bipropellant Stage IV Post Boost Propulsion System, renamed Phoenix. MSFC gained experience with the RS-34 propulsion system on the successful Ares I-X flight test program flown in October 2009. RS-34 propulsion system components were harvested from stages supplied by the USAF and used on the Ares I-X Roll control system (RoCS). The heritage hardware proved extremely robust and reliable and sparked interest for further utilization on other potential in-space applications. MSFC is working closely with the USAF to obtain RS-34 stages for re-use opportunities. Prior to pursuit of securing the hardware, MSFC commissioned the Advanced Concepts Office to understand the capability and potential applications for the RS-34 Phoenix stage as it benefits NASA, DoD, and commercial industry. As originally designed, the RS-34 Phoenix provided in-space six-degrees-of freedom operational maneuvering to deploy multiple payloads at various orbital locations. The RS-34 Phoenix Utilization Study sought to understand how the unique capabilities of the RS-34 Phoenix and its application to six candidate missions: 1) small satellite delivery (SSD), 2) orbital debris removal (ODR), 3) ISS re-supply, 4) SLS kick stage, 5) manned GEO servicing precursor mission, and an Earth-Moon L-2 Waypoint mission. The small satellite delivery and orbital debris removal missions were found to closely mimic the heritage RS-34 mission. It is believed that this technology will enable a small, low-cost multiple satellite delivery to multiple orbital locations with a single boost. For both the small

  2. FREQUENCY OF THE VIRUS OF THE FELINE LEUKEMIA (FeLV IN DOMESTIC FELINES (Felis catus SEMI-DOMICILED IN THE MUNICIPALITIES OF PELOTAS AND RIO GRANDE FREQUÊNCIA DO Vírus da Leucemia Felina (VLFe em FELINOS DOMÉSTICOS (Felis catus SEMIDOMICILIADOS NOS MUNICÍPIOS DE PELOTAS E RIO GRANDE

    Directory of Open Access Journals (Sweden)

    Dilmara Reischak

    2010-04-01

    Full Text Available Considering the importance of FeLV in the feline clinic, as well as the likely agent spread from a symptomatic or asymptomatic feline bearer, this work has as objective the study of the frequency of FeLV in felines residents in the cities of the Pelotas and Rio Grande, municipalities located in the south area of Brazil. For that, the blood of 120 semi-domiciled animals was collected for the detection of the retrovirus through the Indirect Immunofluorescence technique (IFA. FeLV was detected in 38,3% (46/120 of the studied animals, representing a larger frequency considering other studies accomplished in other areas of Brazil, what confirms the importance of FeLV in the studied region.

    KEY WORDS: FeLV, felines, immunofluorescence, retrovirus.

    Considerando a importância do VLFe na clínica felina, assim como a possível disseminação do agente a partir de um felino portador sintomático ou assintomático, o estudo tem como objetivo verificar a frequência de viremia pelo VLFe em felinos residentes em Pelotas e Rio Grande, municípios situados na região sul do Brasil. Para isso foi coletado sangue de 120 animais semidomiciliados para a detecção do retrovírus através da técnica de imunofluorescência indireta (IFI. Detectou-se a viremia em 38,3% (46/120 dos animais estudados, representando uma frequência maior em relação a outros estudos realizados no Brasil, o que confirma a importância deste agente na região estudada.

    PALAVRAS-CHAVES: Felinos, imunofluorescência, retrovírus, VLFe.

  3. Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population.

    Directory of Open Access Journals (Sweden)

    James Cheng-Chung Wei

    Full Text Available Ankylosing spondylitis (AS is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. However, the development of anklosing spondylitis is unclear. Human leukocyte antigens HLA-B27 and ERAP1 have been widely reported to be associated with AS susceptibility. A recent genome-wide association study (GWAS showed that two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569 and within ANO6 at 12q12 (rs17095830 contribute to the risk of AS in Han Chinese. In this study, we enrolled 475 AS patients and 475 healthy subjects to assess whether these genetic variations contribute to the susceptibility and the severity of AS in the Taiwanese population. The correlation between genetic polymorphisms, AS activity indexes, (namely, BASDAI, BASFI and BAS-G and AS complications (uveitis and inflammatory bowel disease were tested using the markers, rs4552569 and rs17095830. Although no association between rs4552569/rs17095830 genetic polymorphisms and AS susceptibility/severity was found, a significant association between rs17095830 and inflammatory bowel disease was observed in a Taiwanese population.

  4. Cohort profile update: 2004 Pelotas (Brazil) Birth Cohort Study. Body composition, mental health and genetic assessment at the 6 years follow-up.

    Science.gov (United States)

    Santos, Iná S; Barros, Aluísio J D; Matijasevich, Alicia; Zanini, Roberta; Chrestani Cesar, Maria Aurora; Camargo-Figuera, Fabio Alberto; Oliveira, Isabel O; Barros, Fernando C; Victora, Cesar G

    2014-10-01

    This is an update of the 2004 Pelotas Birth Cohort profile, originally published in 2011. In view of the high prevalence of overweight and mental health problems among Brazilian children, together with the availability of state-of-the-art equipment to assess body composition and diagnostic tests for mental health in childhood, the main outcomes measured in the fifth follow-up (mean age 6.8 years) included child body composition, mental health and cognitive ability. A total of 3722 (90.2%) of the original mothers/carers were interviewed and their children examined in a clinic where they underwent whole-body dual X-ray absorptiometry (DXA), air displacement plethysmography and a 3D photonic scan. Saliva samples for DNA were obtained. Clinical psychologists applied the Development and Well-Being Assessment questionnaire and the Wechsler Intelligence Scale for Children to all children. Results are being compared with those of the two earlier cohorts to assess the health effects of economic growth and full implementation of public policies aimed at reducing social inequalities in the past 30 years. For further information visit the programme website at [http://www.epidemio-ufpel.org.br/site/content/coorte_2004/questionarios.php]. Applications to use the data should be made by contacting 2004 cohort researchers and filling in the application form available at [http://www.epidemio-ufpel.org.br/site/content/estudos/formularios.php].

  5. Distúrbios menstruais entre mulheres de 15-54 anos de idade em Pelotas, Rio Grande do Sul, Brasil: estudo de base populacional

    Directory of Open Access Journals (Sweden)

    Raquel Siqueira Barcelos

    2013-11-01

    Full Text Available Para avaliar a prevalência de distúrbios menstruais e sua distribuição conforme paridade e características demográficas, sociais e comportamentais, entre 15-54 anos de idade, realizou-se estudo transversal de base populacional, em Pelotas, Rio Grande do Sul, Brasil, com 1.078 mulheres. Foram investigados sangramento menstrual excessivo, sangramento intermenstrual, ciclo menstrual curto, ciclo menstrual longo e menstruação prolongada. Foram calculadas as taxas de prevalência, com intervalos de 95% de confiança. A prevalência global de distúrbios menstruais foi 46,4% (43,4-49,4. O mais prevalente foi sangramento menstrual excessivo (23,2%; 20,5-25,8, seguido de ciclo menstrual curto (19,2%; 16,6-21,8, ciclo menstrual longo (14,8%; 12,7-16,9, sangramento intermenstrual (11,1%; 9,1-13,2 e menstruação prolongada (7,9%; 6,3-9,4. Os distúrbios menstruais são frequentes na população, estando associados à idade maior que 34 anos, escolaridade menor que cinco anos, maior paridade, laqueadura tubária e tabagismo.

  6. Imagens de humor e de política: relações entre a imprensa ilustrada e a simbologia republicana. Pelotas, 1880-1889

    Directory of Open Access Journals (Sweden)

    Aristeu Elisandro Machado Lopes

    2009-04-01

    Full Text Available Nos anos 1880, a propaganda republicana começou em Pelotas com a fundação do clube e do partido republicanos. A partir daí, a propagação das atividades era constantemente noticiada nos órgãos da imprensa local. Entre eles, dois periódicos eram ilustrados e humorísticos: Cabrion (1879-1881 e A Ventarola (1887-1889. Sem descuidar da função primordial do jornal – provocar o riso do leitor através de uma apresentação humorística da realidade – esses periódicos informaram e satirizaram o processo republicano. Este artigo busca analisar a vinculação entre esses periódicos e a questão republicana durante as atividades de propaganda e, especificamente, como ocorreu o emprego da simbologia republicana na elaboração das ilustrações.

  7. [Medical auditing: procedures assessment in the women's integral health care program in the Vila Municipal Health Clinic, Pelotas, Rio Grande do Sul, Brazil

    Science.gov (United States)

    Costa; Roman; Luz; Manzolli; Correa; Recuero

    1998-04-30

    This study is based on a medical audit of the Vila Municipal Health Clinic, Pelotas, Rio Grande do Sul. We collected data from family medical records in 1992,1993, and 1994. The data concerned the Women's Integral Health Care Program. We collected information on age, visits for medical and non-medical reasons, blood pressure, breast examination, coverage of Pap smear testing, and contraceptive methods. On average, women visited the clinic 3.5 to 4 times a year; 53% of the women were between 20 and 39 years of age; 42.5% of the women had had a Pap smear in the previous three years; 19% of the women had had their breasts examined. Blood pressure measurement was the most common procedure recorded in this clinic. We believe quality of medical records is a factor in patient care. We expect a critique of the low-quality medical records found in this audit can serve as the basis for a discussion among the health care team, with a view towards improving medical care, thereby benefiting patients.

  8. FLORISTIC AND SIMILARITY ANALYSIS OF TREE SPECIES IN “MATA DA PRAIA DO TOTÓ’, PELOTAS, RIO GRANDE DO SUL STATE BRAZIL

    Directory of Open Access Journals (Sweden)

    Tiago Schuch Venzke

    2012-12-01

    Full Text Available http://dx.doi.org/10.5902/198050987548The floristic survey of tree species was performed in a ‘Restinga’ forest, municipality of Pelotas, RioGrande do sul State, Brazil. The area studied is known as ‘Mata da Praia do Totó’(‘Totó’ beach forest,and comprises a remnant formed by a sandy and turf ‘Restinga’ forest. A total 65 native species weresampled comprising 51 genera distributed in 34 families. The family with the greatest number of specieswasMyrtaceae, with ten species, followed bySalicaceaeandRubiaceae.The most representative generawereMyrsineandEugenia,respectivelly sampled with four and three species. The analysis of similaritysampled that the sandy forest is floristically related to riparian and hillside forests and the forest peat isrelated to other forests located in areas of permanent water saturation of soil. Species richness of the siteis high for ‘Restinga’ forests in Rio Grande do Sul state, probably due to the influence of forests located inSerra dos Tapes and by diversity of the environments that make up the study area.

  9. Inhaler use in adolescents and adults with self-reported physician-diagnosed asthma, bronchitis, or emphysema in the city of Pelotas, Brazil

    Directory of Open Access Journals (Sweden)

    Paula Duarte de Oliveira

    2013-06-01

    Full Text Available OBJECTIVE: To evaluate the characteristics of users of inhalers and the prevalence of inhaler use among adolescents and adults with self-reported physician-diagnosed asthma, bronchitis, or emphysema. METHODS: A population-based study conducted in the city of Pelotas, Brazil, involving 3,670 subjects ≥ 10 years of age, evaluated with a questionnaire. RESULTS: Approximately 10% of the sample reported at least one of the respiratory diseases studied. Among those individuals, 59% reported respiratory symptoms in the last year, and, of those, only half reported using inhalers. The use of inhalers differed significantly by socioeconomic status (39% and 61% for the lowest and the highest, respectively, p = 0.01. The frequency of inhaler use did not differ by gender or age. Among the individuals reporting emphysema and inhaler use, the use of the bronchodilator-corticosteroid combination was more common than was that of a bronchodilator alone. Only among the individuals reporting physician-diagnosed asthma and current symptoms was the proportion of inhaler users higher than 50%. CONCLUSIONS: In our sample, inhalers were underutilized, and the type of medication used by the individuals who reported emphysema does not seem to be in accordance with the consensus recommendations.

  10. A survey of oral and maxillofacial biopsies in children: a single-center retrospective study of 20 years in Pelotas-Brazil

    Directory of Open Access Journals (Sweden)

    Giana da Silveira Lima

    2008-12-01

    Full Text Available Despite the large number of published cases about oral and maxillofacial pediatric lesions, the literature is scarce on epidemiological studies regarding the prevalence of these entities. This study retrieved oral and maxillofacial pediatric lesions from the Center of Diagnosis of Oral Diseases (CDDB at the Dental School of the Federal University of Pelotas (UFPEL, comprising a 20-year period (1983-2002. From the total of 9,465 biopsies received in this period, 625 (6.6% were from children aged 0 to 14 years. Regardless of the histopathological diagnosis, patient data referring to lesion location, sex and age were collected. Diagnoses were grouped in 13 categories. As much as 89% of the cases occurred in patients aged 7 to 14 years (53% in females and 47% in males. Mucocele (17.2% was the most common type of lesion, followed by dentigerous cyst (8.6%. In the category of odontogenic tumors, odontoma was the most frequent lesion (64.2%. Malignant lesions were observed in a small section of the sample (1.2%. Generally, the results of the present study are in line with those reported in the literature concerning the most prevalent lesions in the pediatric population. Most lesions were benign, and malignant lesions were diagnosed in a very small part of the sample.

  11. Relationship Between Chronic Tinnitus and Glial Cell Line-Derived Neurotrophic Factor Gene rs3812047, rs1110149, and rs884344 Polymorphisms in a Turkish Population.

    Science.gov (United States)

    Orenay-Boyacioglu, Seda; Coskunoglu, Aysun; Caki, Zerrin; Cam, Fethi Sirri

    2016-08-01

    Glial cell line-derived neurotrophic factor (GDNF) plays a key role in early development of central auditory pathway and the inner ear. However, the auditory pathway studies of GDNF gene polymorphisms are scarce in the literature, and the studies especially associated with tinnitus are limited. Our study aimed to identify whether GDNF gene polymorphisms play any roles in the pathophysiology of tinnitus by investigating the relationship between tinnitus and GDNF polymorphisms. A total of 52 patients with chronic tinnitus and ages ranging from 18 to 55 were admitted to the Ear-Nose-Throat outpatient clinic of Celal Bayar University Medical Faculty Hospital of Manisa, Turkey and constituted the study group. Another 42 patients of the same age range, without tinnitus symptoms and lacking any systemic disease, were also admitted to the clinic and formed the control group. The tympanometric, audiological, and psychoacoustic assessments of the subjects were performed. Deoxyribonucleic acid samples obtained using venous blood taken for routine inspections were used to investigate GDNF gene polymorphisms (rs884344, rs3812047, and rs1110149) by polymerase chain reaction-based restriction fragment length polymorphism method. No correlation could be detected between GDNF rs884344 and rs3812047 polymorphisms and subjects with tinnitus (p > 0.05). Heterozygosity was significantly lower for GDNF rs1110149 polymorphism in tinnitus subjects compared to the controls (p tinnitus and control groups (p > 0.05). Failure to detect correlations between tinnitus and GDNF gene polymorphisms suggests this may be due to the fact that the GDNF gene has a variable expression pattern in different tissues and pathologies. Therefore, the study should be improved and its scope should be expanded by including a larger group of patients and different tissues to investigate the expression pattern of GDNF.

  12. Trails, RS2477, wintqutrs, Published in 2008, Carbon County GIS.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Field Survey/GPS information as of 2008. It is described as 'wintqutrs'. Data by this publisher are...

  13. Trails, RS2477, picpts, Published in 2006, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2006. It is described as 'picpts'. Data by this publisher are often provided in...

  14. Trails, RS2477, centerlines83, Published in 2008, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2008. It is described as 'centerlines83'. Data by this publisher are often...

  15. Trails, RS2477, 34b, Published in 2006, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2006. It is described as '34b'. Data by this publisher are often provided in...

  16. THE HISTORY OF LABORATORY ANIMALS AND THE 3RS

    DEFF Research Database (Denmark)

    Alstrup, Aage Kristian Olsen

    This talk will give an introduction to the history of the use of laboratory animals with focus on the history of the three Rs (3Rs). We will see how animal experimentation has been performed early in our civilization, and how the suffering of animals has been justified. This will include Rene...... Descartes´s mechanical view of animals in the seventeenth century, and Charles Darwin's ambivalent relationship to animal experimentation, which he views as cruel but necessary. In the 1870s the Danish Foundation for Protection of Animals (“Dyrenes Beskyttelse”) and Professor Peter Panum discussed the use...... Principles of Humane Experimental Technique”. This book founded the concept of the 3Rs: replacement, reduction and refinement. Today, the concept of the 3Rs is widespread, and this concept is incorporated into the laboratory animal legislation of many countries, including EU directives and Danish legislation...

  17. Association of rs1568885, rs1813443 and rs4411591 polymorphisms with anti-TNF medication response in Greek patients with Crohn’s disease

    Science.gov (United States)

    Thomas, Diamantis; Gazouli, Maria; Karantanos, Theodoros; Rigoglou, Stella; Karamanolis, Georgios; Bramis, Konstantinos; Zografos, George; Theodoropoulos, George E

    2014-01-01

    AIM: To investigate the correlation between rs1568885, rs1813443 and rs4411591 polymorphisms and response to infliximab in a cohort of Greek patients with Crohn’s disease (CD). METHODS: One hundred and twenty-six patients diagnosed with CD based on standard clinical, endoscopic, radiological, and pathological criteria were enrolled in this study at the Gastroenterology Unit of the 2nd Department of Surgery and at the Colorectal Unit of the 1st Department of Propaedeutic Surgery. Infliximab at a dose of 5 mg/kg was administered intravenously at weeks 0, 2, 6 and then every 8 wk. Clinical and serological responses were assessed using the Harvey-Bradshaw Index and serum C-reactive protein (CRP) levels, respectively, and the endoscopic response was evaluated by ileocolonoscopy performed at baseline and after 12-20 wk of therapy. The changes in endoscopic appearance compared to baseline were classified into four categories, and patients were classified as responders and non-responders. Genomic DNA from whole peripheral blood was extracted and genotyping was performed by allele-specific polymerase chain reactions. χ2 test with Yate’s correction based on the S-Plus was used to compare the genotype frequencies. RESULTS: Eighty patients (63.49%) were classified as complete and 32 (25.39%) as partial responders to infliximab, while 14 (11.11%) were primary non-responders. No correlation was found between response to infliximab and patients’ characteristics such as age, gender and disease duration. There was consistency between Harvey-Bradshaw index scores and serum CRP levels. The TT genotype of the rs1568885 polymorphism was significantly related to partial response (P = 0.024) and resistance to infliximab (P = 0.007) while the AT genotype was more frequent in partial responders (P = 0.035) and in primary non-responders (P = 0.032). Regarding rs1813443, the CC genotype was found to be associated with partial response (P = 0.005) and primary resistance (P = 0.002) to

  18. Improving Reliability of Communication in RS-485 Design

    Institute of Scientific and Technical Information of China (English)

    蒋小平; 刘晓辉

    2002-01-01

    Three aspects of RS-485 application, which affect the reliability of communication of data system are analyzed and discussed. In network configuration, it presents the optimal configuration for the bus of RS-485, the better rule for derivative line and the choice for termination. In hardware design, it presents three parts of driver's peripheral circuit. In control software design, it presents a method of using 75176's DE line to control the driver.

  19. Have the 3Rs and alternatives been effectively explored?

    Institute of Scientific and Technical Information of China (English)

    Adrian Smith

    2015-01-01

    Although the concept of the 3Rs was developed in the 1950s, it took many years before it became a central theme when planning and conducting experiments which might involve animals.There are still many ways in which protocols can be im-proved to increase both animal welfare and the reliability of the scientific data obtained from the studies. This paper gives some practical advice on how the 3Rs can be implemented more thoroughly in animal research.

  20. The 3Rs principle – mind the ethical gap!

    DEFF Research Database (Denmark)

    Olsson, I. Anna S.; Franco, Nuno H.; Weary, Daniel M.;

    2012-01-01

    Over the 50 years since they were first proposed, the 3Rs (Replacement, Reduction, Refinement) have made a tremendous impact. These principles seem to unify concerns for better science with causing less harm to animals. The ideas behind the 3Rs are so intuitively compelling that it is tempting to...... effects of repeated exposure to harmful procedures). We conclude that there is now a need for a more thorough ethical discussion on how to resolve these issues....

  1. Reducing the Power-Loss in RS-485 Designs

    Institute of Scientific and Technical Information of China (English)

    蒋小平; 刘晓辉

    2002-01-01

    Power-loss sometimes needs particular consideration in coal mine. This paper analyzes the main three parts of power consuming of RS-485 system, that is quiescent power consuming, transmission power-consuming and peripheral equipment power consuming. How to reduce the power consuming in RS-485 designs is introduced, and also the method of hardware and software design is presented including choosing low power transceiver, optimizing communication data structure, optimizing communication working mode.

  2. The optimal algorithm for Multi-source RS image fusion.

    Science.gov (United States)

    Fu, Wei; Huang, Shui-Guang; Li, Zeng-Shun; Shen, Hao; Li, Jun-Shuai; Wang, Peng-Yuan

    2016-01-01

    In order to solve the issue which the fusion rules cannot be self-adaptively adjusted by using available fusion methods according to the subsequent processing requirements of Remote Sensing (RS) image, this paper puts forward GSDA (genetic-iterative self-organizing data analysis algorithm) by integrating the merit of genetic arithmetic together with the advantage of iterative self-organizing data analysis algorithm for multi-source RS image fusion. The proposed algorithm considers the wavelet transform of the translation invariance as the model operator, also regards the contrast pyramid conversion as the observed operator. The algorithm then designs the objective function by taking use of the weighted sum of evaluation indices, and optimizes the objective function by employing GSDA so as to get a higher resolution of RS image. As discussed above, the bullet points of the text are summarized as follows.•The contribution proposes the iterative self-organizing data analysis algorithm for multi-source RS image fusion.•This article presents GSDA algorithm for the self-adaptively adjustment of the fusion rules.•This text comes up with the model operator and the observed operator as the fusion scheme of RS image based on GSDA. The proposed algorithm opens up a novel algorithmic pathway for multi-source RS image fusion by means of GSDA.

  3. 总线CAN/RS485/RS232协议接口收发模块

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    CAN/RS485/RS232隔离收发模块是集成收发芯片、隔离芯片及DC/DC隔离电源于一体的接口隔离收发模块,可完全取代传统的光耦隔离方案。过去需要收发芯片+隔离芯片/光耦+隔离电源才能实现的整个隔离收发方案,现在仅需要采用一个CAN/RS485/RS232隔离收发模块便可轻松实现,

  4. 隔离式RS485和RS232微型模块收发器

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    LTM2881单通道RS485和LTM2882双通道RS232收发器运用内部感应信号隔离对逻辑电平接口和线路收发器进行隔离,以中断接地环路。这允许大得多的共模电压范围和卓越的共模抑制(〉30kV/μs)。低EMI、1W DC/DC转换器产生驱动RS485或RS232电平的电源,并提供一个额外的5V隔离电源输出,以给任何支持性外部组件供电,

  5. Correlation of rs6756667 and rs7583392 polymorphism of EPAS1 with high altitude polycythemia in male Han population

    Directory of Open Access Journals (Sweden)

    Yu CHEN

    2012-12-01

    Full Text Available Objective  To investigate the correlation between rs6756667 and rs7583392 polymorphism of endothelial Per-Arnt-Sim domain protein 1(EPAS1 and high altitude polycythemia(HAPC in male Han population. Methods  A total of 318 individuals with HAPC and 316 male individuals without HAPC (controls of Han population were enrolled in this study, and genotypes of rs6756667 and rs7583392 were identified by polymerase chain reaction-high resolution melting analysis method. Polymorphism data of this study were compared with that collected from Han males in Beijing in the International HapMap Project database and Tibetan population from previous literature. Results  Genotypes of AA, AG and GG were found in rs6756667 and rs7583392 polymorphism. The frequencies of the three genotypes of rs6756667 in HAPC group and control group were 1.9%, 16.0%, 82.1% and 3.2%, 22.8%, 74.0%, respectively. The distribution of genotypes showed significant difference between HAPC group and control group (P=0.049, with frequency of GG genotype in HAPC group was markedly higher than that of control group (P=0.025. The frequencies of A allele and G allele were significantly different between HAPC group and control group (P=0.011, OR=0.645,95%CI=0.459~0.908. The frequencies of the three genotypes of rs7583392 in HAPC group and control group were 77.7%, 18.6%, 3.7% and 69.0%, 24.0%, 7.0%, respectively, while the frequency distribution of rs7583392 did not match the Hardy-Weinberg equilibrium test. Compared with Han Chinese in Beijing, there was no significant difference in frequency distribution of genotypes or alleles of rs6756667 polymorphism in this study, while statistically significant significance was found as compared with Tibetan population as found from previous literature(χ2=76.133, P<0.0001. Conclusion  Polymorphism of rs6756667 in EPAS1 is associated with the occurrence of HAPC in male Han population, the A allele may be a protective factor against HAPC, while the

  6. 以太网转RS232转换器设计%Ethernet to RS232 Converter Design

    Institute of Scientific and Technical Information of China (English)

    张成俊; 张李超; 史玉升

    2013-01-01

    为了实现现有以RS232为通讯方式的设备的网络化监控和管理,提出了以太网转RS232的转换器设计.利用STM32F107实现了对转换器的硬件设计,对软件模块进行了功能划分,利用主程序和中断服务程序对转换器功能进行软件实现.设计的以太网转RS232转换器具有较强的通用性,在不改变硬件平台的情况下,仅对软件的处理模块进行少量修改便能适应各种RS232协议.%In order to monitor and manage the existed device with RS232 communication protocol,Ethemet to RS232 converter design is necessary.The converter hardware design used STM32F107 as the main MCU.Converter software modules were divided by the converter function.Main program and interrupt service program software were designed to achieve the function of the converter.The designed Ethemet to RS232 converter has strong generality.It can only do small modification in the data handle module to satisfy the variety of RS232 protocol,without change the hardware platform.

  7. A PERCEPÇÃO DOS INTEGRANTES DOS PROGRAMAS AMBIENTAIS QUE TRABALHAM NA GESTÃO AMBIENTAL DA DUPLICAÇÃO DA BR-116/RS SOBRE O PROGRAMA DE COMUNICAÇÃO SOCIAL

    Directory of Open Access Journals (Sweden)

    Manoela Nogueira Soares

    2013-12-01

    Full Text Available Este trabalho tem o objetivo de conhecer a percepção dos integrantes dos Programas Ambientais, desenvolvidos pela Gestão Ambiental, durante as obras de duplicação da BR-116/RS entre os municípios de Guaíba e Pelotas, somando 211 quilômetros de extensão. A referência para a realização das atividades do Programa de Comunicação está baseada no planejamento estratégico do mesmo, desenvolvido a partir das especificações do Estudo de Impacto Ambiental (EIA, que define as áreas de influência direta e indireta do empreendimento e os objetivos das atividades com as comunidades lindeiras às obras e usuários da rodovia. Neste trabalho são utilizados referenciais teóricos que embasam as ações de comunicação desenvolvidas, destacando a relação entre a comunicação e os demais Programas Ambientais previstos para serem executados durante as obras de duplicação da rodovia. A pesquisa bibliográfica e documental se embasa, principalmente, nos pressupostos de Bordenave (1997. A pesquisa de campo é de natureza exploratória, quantitativa e por acessibilidade do pesquisador.

  8. Association between IL-1α rs17561 and IL-1β rs1143634 polymorphisms and periodontitis: a meta-analysis.

    Science.gov (United States)

    Yin, W T; Pan, Y P; Lin, L

    2016-02-05

    Genetic variations in human interleukin-1 (IL-1) genes are known to be involved in inflammatory disorders. The rs17561 and rs1143634 polymorphisms of IL-1α and IL-1β, respectively, have been increasingly recognized as important regulators in the development of periodontitis. However, the existence of a specific association remains controversial. Therefore, we performed a meta-analysis to explore the relationship between IL-1 polymorphism and periodontitis risk. Based on our inclusion criteria, six case-control studies were used, involving a total of 336 periodontitis cases and 366 healthy controls. Our meta-analysis results showed that the T allele of IL-1α rs17561 is positively associated with periodontitis susceptibility. In addition, carriers of this allele (TC + TT genotypes) demonstrated increased risk of this disease. The IL-1β rs1143634 T allele was also positively connected to periodontitis, with TC + TT genotype carriers being significantly more at risk. These results demonstrate that the IL-1α rs17561 and IL-1β rs1143634 polymorphisms are associated with periodontitis.

  9. The Effect of Xuefuzhuyu Oral Liquid on Aspirin Resistance and Its Association with rs5911, rs5787, and rs3842788 Gene Polymorphisms

    Directory of Open Access Journals (Sweden)

    Mei Xue

    2015-01-01

    Full Text Available Aspirin should be continued indefinitely in patients after interventional therapy, but 10% to 40% of patients experience recurrent vascular events despite adequate aspirin therapy, a condition known as aspirin resistance (AR. Xuefuzhuyu oral liquid, derived from the classic recipe Xuefuzhuyu decoction, has been well documented to inhibit platelet aggregation and to improve hemorheology. The aims of this study were to investigate the effects of Xuefuzhuyu oral liquid on AR in patients with chronic stable angina after percutaneous coronary intervention (PCI and the possible genetic markers related to the drug response. 43 patients diagnosed as having aspirin resistance or semi-resistance were randomly divided into control and treatment groups after screening 207 stable CHD patients. Platelet aggregation rate was determined using turbidimetry. Three single nucleotide polymorphisms in COX-1 (rs5787, rs3842788 and GP IIb (rs5911 were genotyped in whole blood samples using ABI PRISM 7900 HT Fast Real-Time instrument and ABI PRISM 3730 DNA Sequencer. The results showed that Xuefuzhuyu oral liquid could effectively improve blood stasis syndrome and AR by inhibiting ADP-induced platelet aggregation and that patients with the rs5911 genetic variant exhibited better drug response upon treatment with Xuefuzhuyu oral liquid, which suggests Xuefuzhuyu oral liquid as a new possible drug for the prevention of AR.

  10. Eudragit RS PO nanoparticles for sustained release of pyridostigmine bromide

    Energy Technology Data Exchange (ETDEWEB)

    Hoobakht, Fatemeh; Ganji, Fariba, E-mail: fganji@modares.ac.ir; Vasheghani-Farahani, Ebrahim [Tarbiat Modares University, Biomedical Engineering Group, Chemical Engineering Department (Iran, Islamic Republic of); Mousavi, Seyyed Mohammad [Tarbiat Modares University, Biotechnology Group, Chemical Engineering Department (Iran, Islamic Republic of)

    2013-09-15

    Pyridostigmine bromide (PB) is an inhibitor of cholinesterase, which is used in the treatment of myasthenia gravis and administered for protection against exposure to toxic nerve agents. Tests were done to investigate prolonging the half-life of PB and improving its release behavior. PB was loaded in nanoparticles (NPs) of Eudragit RS PO (Eu-RS) prepared using the technique of quasi emulsion solvent diffusion. Variables of output power of the sonicator, bath temperature and mixing time, were chosen as the optimization factors to obtain the minimum sized NPs. In addition, emulsions were tested at different ratios of drug-to-polymer by dynamic light scattering to determine size and zeta potential of NPs. UV-spectroscopy was used to determine PB content of the NPs. Drug-loaded NPs were characterized by scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectra. Results determined that mixing time had a significant impact on the size of Eu-RS NPs, but power output of sonicator and bath temperature had no significant effect. The particle size obtained at the optimum condition (power output of 70 W, bath temperature of 33 Degree-Sign C, and mixing time of 7 min) was less than 200 nm (optimum sizes were 138.9 and 179.5 nm for Eu-RS and PB-loaded Eu-RS NPs, respectively). The optimum PB-loaded Eu-RS NPs at the PB to Eu-RS weight ratio of 1-4 and 20 % of loaded PB released from the nanocarriers within 100 h.

  11. Maternal smoking in successive pregnancies and recurrence of low birthweight: the 2004 Pelotas birth cohort study, Brazil Tabaquismo materno en sucesivas gestaciones y recurrencia de bajo peso al nacer: cohorte de nacimientos de Pelotas, Río Grande do Sul, Brasil, 2004 Tabagismo materno em sucessivas gestações e recorrência de baixo peso ao nascer: coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 2004

    Directory of Open Access Journals (Sweden)

    Iândora Krolow Timm Sclowitz

    2013-01-01

    Full Text Available To evaluate the frequency of maternal smoking in successive pregnancies and its association with repetition of low birthweight, a study was conducted of a subsample of mothers from the 2004 Pelotas Birth Cohort in Brazil. Only women with previous histories of low birthweight newborns were included. Women with ≥ 2 previous births were eligible only if at least one of the two births immediately preceding the 2004 birth had low birthweight. From 4,458 births, 565 were included in this study. Frequency of smoking was 32.4%. Considering past pregnancies, 67.1% of mothers never smoked, 21.4% smoked during all pregnancies, 6.5% were ex-smokers, and 5% smoked only during the current pregnancy. In the adjusted analyses, when compared to mothers who never smoked, those who smoked during all pregnancies had 2.5 times greater probability of low birthweight recurrence in 2004 (PR = 2.5; 95%CI: 1.32-4.80. Smoking persistence is an important factor for the recurrence of low birthweight in successive pregnancies.Este estudio fue realizado en una submuestra de madres de la cohorte de nacimientos de Pelotas, Río Grande do Sul, Brasil, de 2004 para evaluar la frecuencia y asociación del tabaquismo en sucesivas gestaciones con el fenómeno de repetición del bajo peso al nacer. Se incluyeron solamente mujeres con antecedentes en el historial médico de recién nacidos con bajo peso al nacer. Se elegían a mujeres con ≥ 2 partos anteriores, solamente, si por lo menos uno de los dos partos inmediatamente anteriores al de 2004 hubiera sido de bajo peso al nacer. De los 4.458 nacimientos, 565 fueron incluidos en la muestra. La frecuencia de tabaquismo fue de un 32,4% y, teniendo en consideración las gestaciones anteriores, un 67,1% nunca fumaron; un 21,4% siempre fumaron; un 6,5% eran ex-fumadoras; y un 5,0% fumaron solamente en la gestación actual. En el análisis multivariable, las madres que fumaron en todas las gestaciones tuvieron una probabilidad 2

  12. Freqüência das malformações múltiplas em recém-nascidos na Cidade de Pelotas, Rio Grande do Sul, Brasil, e fatores sócio-demográficos associados

    Directory of Open Access Journals (Sweden)

    Castro Martha Lopes Schuch de

    2006-01-01

    Full Text Available Este estudo visa determinar a freqüência, correlacionar possíveis agentes causais e monitorizar a ocorrência de malformações múltiplas na população de Pelotas, Rio Grande do Sul, Brasil. Abrange todos os nascimentos ocorridos entre 1990 e 2002 nas maternidades de Pelotas, com peso superior a 500g. Para cada recém-nascido malformado (caso, tomou-se um neonato vivo (controle, pareado a ele, sem malformação e de igual sexo. Formou-se um banco de dados mediante o preenchimento dos formulários-modelo ECLAMC - MONITOR edição 1982, que foram tabulados pelo programa SPSS. Para a análise estatística, utilizou-se o Teste t de Student e chi2. No período em estudo nasceram 71.500 crianças. Dentre essas, 0,11% recém-nascidos apresentaram malformações múltiplas. Foram encontrados resultados significativos para o peso, gemelaridade e nascimento, a etnia dos antepassados, a idade paterna, o número de abortos e natimortos prévios. Em Pelotas, a ocorrência de recém-nascidos que apresentavam malformações ao nascer, no período do estudo, foi de 1,37%. A freqüência de recém-nascidos com malformações múltiplas é de 8,1%, predominantemente no sexo feminino e nos nascimentos ocorridos no inverno.

  13. La tradición lúdica en el currículum educativo. Los juegos y deportes de pelota en Educación Física: una propuesta comprensiva

    Directory of Open Access Journals (Sweden)

    Oidui Usabiaga Arruabarrena

    2012-03-01

    Full Text Available Los juegos han estado basados tradicionalmente en el pacto previo de las condiciones del desafío entre dos bandos. Mediante el pacto, se equilibraban las posibilidades de los contendientes de conseguir la victoria, pues se analizaban las características de los jugadores y sus habilidades y se introducían modificaciones. Esto ha ocurrido de la misma forma en los juegos directos de pelota, que son los que nos ocupan, todavía vivos en algunas zonas del estado como el País Vasco, Navarra o el País Valenciano. Este conocimiento de dichos juegos proviene de una investigación de índole etnográfica desarrollada en el 2007 con el objetivo de rescatar, catalogar y describir los juegos directos de pelota vascos y valencianos. A partir de este trabajo, proponemos el diseño de una progresión didáctica para la introducción de estas actividades en las sesiones de educación física de secundaria. Y lo hacemos desde una perspectiva comprensiva, en la cual el alumnado tiene gran protagonismo no solo en la práctica, sino en el diseño de los desafíos. De este modo, se trata de que el alumnado identifique las modificaciones del juego y los efectos que ellas producen para, con ello, proponer desafíos a otros equipos. Dicha práctica, además, será evaluada por todas las partes. En definitiva, se trata de poner sobre la mesa una propuesta moderna basada en antiguos juegos de pelota.

  14. Food intake profiles of children aged 12, 24 and 48 months from the 2004 Pelotas (Brazil birth cohort: an exploratory analysis using principal components

    Directory of Open Access Journals (Sweden)

    Gatica Giovanna

    2012-04-01

    Full Text Available Abstract Objectives To identify food intake profiles of children during their first four years of life and assess its variations according to sociodemographic and behavioral characteristics. Methods The Pelotas Birth Cohort Study (Brazil recruited 4,231 liveborns, who were followed-up at ages 3, 12, 24 and 48 months. Food consumption data of children aged 12, 24 and 48 months was collected using a list of foods consumed during a 24-hour period prior to the interview. The food profiles were identified with the use of principal component analysis (PCA for each age studied. Results Five components were identified at each age, four of them similar in all time points, namely: beverages, milks, staple, and snacks. A meat & vegetables component was identified at 12 and 24 months and a treats component at 48 months. The greatest nutritional differences were found among children from different socioeconomic levels. With regard to the milks component, higher breast milk intake compared to cow's milk was seen among poorer children (12- and 24-month old and higher milk and chocolate powdered milk drink consumption was seen among more affluent children aged 48 months. Poorer children of less educated mothers showed higher adherence to the treats component (48 months. Regarding to the snack component, poorer children consumed more coffee, bread/cookies while more affluent children consumed proportionately more fruits, yogurt and soft drinks. Child care outside of the home was also a factor influencing food profiles more aligned with a healthier diet. Conclusions The study results showed that very early in life children show food profiles that are strongly associated with social (maternal schooling, socioeconomic position and child care and behavioral characteristics (breast-feeding duration, bottle-feeding and pacifier use.

  15. The Tutorial Education Program on the Formation of the New Milenium's Meteorologist: 20 Years of Project Experience at Universidade Federal de Pelotas - Brazil

    Science.gov (United States)

    Foster, P.

    2012-12-01

    The Programa de Educação Tutorial (Tutorial Education Program), also known as "PET", has the objective to finance students with potential, encouraging and providing extracurricular activities in order to promote the integration with the academic market and the development of study programs in graduate school, preparing a professional that in the future will operate in a global market, transforming and fighting for the professional interests of their class. The design of the program dates back to 1970 and is based on the model of learning and guidance to form the student. The groups are composed gradually, through an annual selection. The deployment and implementation of the groups consider the inclusion of new members in different stages of their school program, working in an integrated manner. To apply, students must submit satisfactory academic performance, without failures on any course and commit to devote a minimum of twenty hours per week to the program activities. Deployed at Universidade Federal de Pelotas - Brazil, in 1991, the group has contributed to the training of students of Meteorology through the concept of teaching-research-extension activities. We believe that PET has been of utmost importance in the training of the new millennium's professional, given that the objectives of this program seek to provide an excellent level of academic training to undergraduates, encouraging their entry into the graduate studies; stimulating the improvement of the quality of teaching degree through the development of new practices and teaching experience; multiplying the activities developed by scholars and increase their interactions with program's faculty and other students of the institution. With the highly competitive market requiring specialized professionals, the high investment in students with potential can be reversed for the benefit of the profession.

  16. RS trigger based relaxation oscillator for temperature measurement circuit

    Institute of Scientific and Technical Information of China (English)

    ZOU Zhi-ge; ZOU Xue-cheng; JIAN Wen-xiang; LEI Jian-ming

    2008-01-01

    Resistance-to-time converter is always used for digital temperature measurement. An reset-set (RS) trigger based, relaxation oscillator based temperature measurement circuit, which is used to convert the change of thermistor sensor into a frequency signal for later processing, has been presented in this article. The RS trigger, which is composed of two inverters designed with distinct logical transition threshold voltages by changing the metal-oxide-semiconductor (MOS) transistor gains, has the same function as the Schmitt trigger in the relaxation oscillator. The advantage of the RS trigger based Schmitt trigger is that it reduces the dependence to supply voltage, chip temperature, and process variation. This temperature measurement circuit has been applied in a clinical thermometer chip that can measure temperature to an accuracy of better than 0.05℃ down to 1.1 V battery voltage. It is fabricated in 0.5double metal single poly complementary MOS (CMOS) process.

  17. USB/RS232转换器的实现%Implementation of USB/RS232 converter

    Institute of Scientific and Technical Information of China (English)

    胡建平; 李雪红; 戴华林

    2004-01-01

    USB作为一种新的PC机互连协议,使外设到计算机的连接更加高效、便利,是计算机外设接口的发展趋势,将逐步取代RS232协议串口,因此很多传统的RS232接口设备都将面临一个向USB接口转换的问题.在实验的基础上总结出利用FT232BM芯片来开发USB/RS232转换器是最为简洁有效的方案,详细介绍了USB/RS232双向转换芯片FT232BM的工作原理、内部结构、引脚分布及功能,给出了利用FT232BM实现USB/RS232转换器的典型设计电路.

  18. Polymorphisms rs12998 and rs5780218 in KiSS1 Suppressor Metastasis Gene in Mexican Patients with Breast Cancer

    Directory of Open Access Journals (Sweden)

    Edhit Guadalupe Cruz Quevedo

    2015-01-01

    Full Text Available Aims. KiSS1 is a metastasis suppressor gene associated with inhibition of cellular chemotaxis and invasion attenuating the metastasis in melanoma and breast cancer cell lines. Along the KiSS-1 gene at least 294 SNPs have been described; however the association of these polymorphisms as genetic markers for metastasis in breast cancer studies has not been investigated. Here we describe two simple PCR-RFLPs protocols to identify the rs5780218 (9DelT and the rs12998 (E20K KiSS1 polymorphisms and the allelic, genotypic, and haplotypic frequencies in Mexican general population (GP and patients with benign breast disease (BBD or breast cancer (BC. Results. The rs5780218 polymorphism was individually associated with breast cancer (P=0.0332 and the rs12998 polymorphism shows statistically significant differences when GP versus case (BC and BBD groups were compared (P<0.0001. The H1 Haplotype (G/- occurred more frequently in BC group (0.4256 whereas H2 haplotype (G/T was the most prevalent in BBD group (0.4674. Conclusions. Our data indicated that the rs5780218 polymorphism individually confers susceptibility for development of breast cancer in Mexican population and a possible role as a genetic marker in breast cancer metastasis for H1 haplotype (Wt/variant in KiSS1 gene must be analyzed in other populations.

  19. Associação entre as características individuais e sócio-econômicas e os acidentes do trabalho em Pelotas, Rio Grande do Sul, Brasil Association between individual and socioeconomic characteristics and work-related accidents in Pelotas, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Rosângela da Costa Lima

    1999-09-01

    Full Text Available O presente estudo, do tipo caso-controle, teve como objetivo estudar a associação entre as características individuais e sócio-econômicas e os acidentes de trabalho. Os casos (n = 264 foram acidentes de trabalho típicos notificados do Instituto Nacional de Seguridade Social de Pelotas em 1996. Os trabalhadores foram entrevistados em suas residências, com um questionário padronizado. Foram excluídos os dois acidentes que levaram a óbito e os que afastaram o acidentado do trabalho por menos de sete dias. Para cada caso, foram selecionados três tipos de controle: um colega de trabalho, um vizinho e um controle populacional. Os critérios de emparelhamento foram idade (mais ou menos cinco anos, sexo e não ter sofrido acidente no último mês. Todos os casos e controles tinham vínculo formal de trabalho e residiam na zona urbana da cidade. Os dados foram analisados por meio de regressão logística condicional. A escolaridade e a renda familiar mensal foram as principais variáveis preditoras dos acidentes do trabalho. Os efeitos da idade, da cor da pele, do hábito de fumar, da dependência de álcool (questionário CAGE e dos eventos estressantes desapareceram após o ajuste para escolaridade e renda.A case-control study was conducted to study the association between individual and socioeconomic characteristics and occupational accidents. Cases were 264 workers who had suffered a "typical" occupational accident registered at the National Institute of Social Security in the city of Pelotas in 1996. Workers were interviewed in their homes with a standardized questionnaire. Two fatal accidents were excluded, as were those leading to absence from work for less than seven days. For each case, three controls were selected: a colleague from the same workplace, a neighbor, and a population control. These were matched to cases by age (±5 years and sex and had not suffered a work-related accident in the preceding month. All cases and controls

  20. Dietary assessment in the 1993 Pelotas (Brazil birth cohort study: comparing energy intake with energy expenditure Avaliação dietética da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993: uma comparação da ingestão e do gasto de energia

    Directory of Open Access Journals (Sweden)

    Denise P. Gigante

    2010-11-01

    Full Text Available The study aims to describe and compare two methods of energy intake assessment and one measure of energy expenditure applied in adolescents from a birth cohort. In a sub-sample of the 1993 Pelotas (Brazil birth cohort, followed up in 2006-7, information on intake was obtained through a food-frequency questionnaire (FFQ and three 24-hour-recalls (24hR, while energy expenditure was assessed using an accelerometer. Bland & Altman plots were used in the analyses in order to compare the methods. The mean difference between FFQ and 24hR was 592 ± 929cal/day. Compared to energy expenditure, intake was overestimated when measured by FFQ (357 ± 968cal/day and underestimated by 24hR (-278 ± 714cal/day. In spite of the great differences between energy intake obtained using the two methods, lower differences were observed when these methods were compared to expenditure.O objetivo do estudo foi descrever e comparar dois métodos de avaliação de consumo calórico e uma medida de gasto energético aplicados em adolescentes de uma coorte de nascimentos. Em uma subamostra da coorte de 1993 de Pelotas, Rio Grande do Sul, Brasil, acompanhada em 2006-2007, informações sobre consumo calórico foram obtidas através de questionário de frequência alimentar (QFA e três recordatórios de 24 horas (R24h, enquanto gasto energético foi avaliado por acelerômetro. Gráficos de Bland & Altman foram usados na comparação dos métodos. A diferença média entre QFA e R24h foi 592 ± 929cal/dia. Ao comparar com gasto energético, o consumo foi superestimado se medido pelo QFA (357 ± 968cal/dia e subestimado pelo R24h (-278 ± 714cal/dia. Apesar da grande diferença no consumo, menores diferenças foram observadas quando os dois métodos foram comparados ao gasto energético.

  1. Experimental use of alcohol in early adolescence: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Uso experimental de álcool no início da adolescência: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Directory of Open Access Journals (Sweden)

    Ricardo B. Noal

    2010-10-01

    Full Text Available The aim of this study was to estimate the prevalence of experimental alcohol intake and associated factors in early adolescence. The overall sample consisted of 4,452 adolescents (mean age = 11.3 years; SD = 0.3 from the 1993 birth cohort in Pelotas, Rio Grande do Sul State, Brazil. Experimental use of alcohol was reported by 17.5% of the interviewees (95%CI: 16.3-18.6, and 5% reported having tried alcohol at nine years of age or younger. Prevalence of experimental alcohol use was higher among adolescents whose mothers had consumed alcohol during pregnancy, whose parents consumed alcohol, who worked outside the home themselves, and who had ever tried smoking. Family strife, parental alcohol intake, and adolescent smoking were strong predictors of experimental alcohol use in early adolescence. Special attention should be targeted to these groups in order to avoid heavy and premature alcohol use in early adolescence.Este trabalho teve como objetivo avaliar a prevalência de uso experimental de bebidas alcoólicas e fatores associados no início da adolescência. Compuseram a amostra 4.452 adolescentes (média = 11,3 anos; DP = 0,3 da coorte de nascimentos de 1993 de Pelotas, Rio Grande do Sul, Brasil. O uso experimental de álcool foi referido por 17,5% dos entrevistados (IC95%: 16,3-18,6 e 5% referiram ter experimentado com nove anos ou menos. O risco de uso experimental de álcool foi maior nos adolescentes cujas mães referiram ter bebido na gestação, quando ambos os pais usavam bebidas alcoólicas, entre os adolescentes que trabalhavam fora e naqueles que já experimentaram cigarro ou outras drogas. As relações familiares, o uso de álcool pelos pais, e o tabagismo do adolescente são os fatores fortemente associados ao uso experimental de álcool no início da adolescência. Mais atenção deveria ser dada especialmente a esses grupos, a fim de combater o consumo precoce de álcool.

  2. Medicine use among adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Utilização de medicamentos por adolescentes: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Directory of Open Access Journals (Sweden)

    Andréa D. Bertoldi

    2010-10-01

    Full Text Available The aim of this study was to investigate medicine use and associated factors among adolescents. This was a prospective cohort study including 4,452 adolescents born in Pelotas, Rio Grande do Sul State, Brazil, in 1993. Information on medicine use in the 15 days prior to the interviews was collected from the mothers. Overall prevalence of medicine use was 30.9%, and 64.7% of the medicines had been prescribed by a physician. The most frequently used pharmacological groups were medicines for the nervous (35.9% and respiratory systems (25.7%. Medicine use was directly associated with socioeconomic status, maternal schooling, complications during pregnancy or delivery, and neonatal problems resulting in the need for intensive care. Underweight and obese adolescents were more likely to use medicines as compared to those with normal body mass index. A direct association was observed between maternal use of hypnotic drugs and sedatives and adolescent medicine use. It is essential to implement educational policies aimed at promoting rational use of medicines by adolescents.O objetivo deste estudo foi investigar o uso de medicamentos e fatores associados em adolescentes. Trata-se de estudo de coorte prospectivo, incluindo 4.452 adolescentes nascidos em Pelotas, Rio Grande do Sul, Brasil, em 1993. As informações sobre o uso de medicamentos pelo adolescente nos 15 dias anteriores à entrevista foram fornecidas pelas mães. A prevalência global de uso de medicamentos foi de 30,9%, sendo que destes, 64,7% foram indicados por médicos. Os grupos farmacológicos mais utilizados foram os medicamentos que atuam nos sistemas nervoso (35,9% e respiratório (25,7%. O uso de medicamentos esteve diretamente associado ao nível econômico, escolaridade da mãe, intercorrência na gravidez ou parto que gerou doença até a adolescência, problema de saúde no momento do nascimento que levou o recém-nascido à UTI, magreza e obesidade. Foi observada uma rela

  3. Sedentary behavior in adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Comportamento sedentário em adolescentes: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Directory of Open Access Journals (Sweden)

    Samuel C. Dumith

    2010-10-01

    Full Text Available The aim of this study was to estimate the prevalence of sedentary behavior and investigate associated factors in adolescents 11 years of age from the 1993 birth cohort in Pelotas, Rio Grande do Sul State, Brazil. Sedentary behavior was investigated with a questionnaire, and was defined as spending more than two hours per day watching television, playing videogames, or using the computer. Of the 4,452 adolescents interviewed, 98% reported watching television, 44% playing videogames, and 22% using the computer. The average time spent on each of these electronic media was 197, 36, and 17 minutes per day, respectively. Prevalence of sedentary behavior was 79.7% (95%CI: 78.6; 80.9 and showed a positive association with socioeconomic level and nutritional status and a negative association with well-being. These 11-year-olds spent extensive time at TV viewing, videogames, and the computer. Special attention should be given to the most exposed groups of adolescents, including the more affluent, overweight, and those with limited schooling.O objetivo deste estudo foi determinar a prevalência e investigar os fatores associados ao comportamento sedentário em adolescentes de 11 anos, pertencentes à coorte de nascimentos de 1993 de Pelotas, Rio Grande do Sul, Brasil. O comportamento sedentário foi coletado por meio de questionário, e definido como ficar mais de duas horas por dia assistindo à televisão, jogando videogame ou usando computador. Dos 4.452 adolescentes entrevistados, 98% assistiam à televisão, 44% jogavam videogame e 22% usavam computador. O tempo médio na frente de cada um desses meios eletrônicos foi, respectivamente, 197, 36 e 17 minutos por dia. A prevalência de comportamento sedentário foi de 79,7% (IC95%: 78,6; 80,9, e teve uma associação positiva com nível socioeconômico e com estado nutricional, e negativa com a escala de bem-estar. O tempo despendido em atividades como ver televisão, jogar videogame e usar computador

  4. Factors associated with weight loss dieting among adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Fatores associados à realização de regime de emagrecimento entre adolescentes: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Directory of Open Access Journals (Sweden)

    Samanta W. Madruga

    2010-10-01

    Full Text Available Evidence has shown the negative effects of unsupervised diets and those with excessive calorie restriction. The aim of this study was to determine the proportion of adolescents engaging in weight loss dieting and associated factors. This was a cross-sectional study of 4,452 adolescents born in Pelotas, Rio Grande do Sul State, Brazil, in 1993. The outcome was defined as adolescents that reported having practiced some type of weight loss dieting in the previous 12 months. Prevalence of such dieting was 8.6% (95%CI: 7.7;9.4, and was higher in girls. Elevated maternal body mass index (BMI was associated with dieting among girls. The adolescent's and parents' view of the adolescent's weight, excess weight, and consumption of diet or light soft drinks were associated with adolescent dieting. There was a positive association between dieting and socioeconomic status. The findings provide important backing for policies aimed at improving adolescents' diet, since they express a major concern over weight and thus a significant percentage of individuals with erroneous and unhealthy behaviors.Evidências mostram efeitos negativos de dietas sem orientação e de alta restrição calórica. O objetivo do estudo foi determinar o percentual de adolescentes que realizaram regime de emagrecimento e os fatores associados a este comportamento. Estudo transversal incluindo 4.452 nascidos em Pelotas, Rio Grande do Sul, Brasil, no ano de 1993. Os adolescentes que relataram ter feito algum tipo de regime com a finalidade de emagrecimento nos últimos 12 meses foram positivos ao desfecho. A freqüência de realização de regime foi de 8,6% (IC95%: 7,7;9,4, sendo maior entre as meninas. O índice de massa corporal (IMC materno elevado associou-se à realização de regime entre meninas. O sentimento do adolescente e dos pais em relação ao peso do jovem, o excesso de peso e o consumo de refrigerantes diet/light mostraram-se associados ao desfecho. Encontrou-se associa

  5. 基于可编程逻辑阵列的RS232至RS422的串行口扩展电路%Extending SCI Circuit of RS232 to RS422 based on PLA

    Institute of Scientific and Technical Information of China (English)

    黄俊杰; 毛晓波; 黄运峰

    2004-01-01

    介绍了利用可编程逻辑阵列把1路RS232扩展至4路RS422的串行口电路设计方法.该扩展电路不占用PC系统资源,同时具有结构简单,使用方便,通用性和可补性强等特点,可广泛应用于主从式多机通讯系统中.

  6. Design of an Active Photoelectric Isolating RS232/RS485 Converter%一种有源光电隔离RS232/RS485转换器设计

    Institute of Scientific and Technical Information of China (English)

    叶鑫; 李文魁; 高敬东; 钟斌

    2015-01-01

    为了提高转换器的抗干扰能力,根据现场应用环境,设计了一种抗干扰能力较强的有源光电隔离RS232/RS485接口转换电路.介绍了转换器的各电路原理图.测试表明,该转换器结构简单、抗干扰能力强、工作可靠,具有很强的应用价值.

  7. MOA-2010-BLG-523: "Failed Planet" = RS CVn Star

    CERN Document Server

    Gould, A; Bond, I A; Udalski, A; Han, C; Jorgensen, U G; Greenhill, J; Tsapras, Y; Pinsonneault, M H; Bensby, T; uFUN, the; MOA,; OGLE,; MiNDSTEp,; RoboNet,

    2012-01-01

    The Galactic bulge source MOA-2010-BLG-523S exhibited short-term deviations from a standard microlensing lightcurve near the peak of an Amax ~ 265 high-magnification microlensing event. The deviations originally seemed consistent with expectations for a planetary companion to the principal lens. We combine long-term photometric monitoring with a previously published high-resolution spectrum taken near peak to demonstrate that this is an RS CVn variable, so that planetary microlensing is not required to explain the lightcurve deviations. This is the first spectroscopically confirmed RS CVn star discovered in the Galactic bulge.

  8. Validation of Omron RS8, RS6, and RS3 home blood pressure monitoring devices, in accordance with the European Society of Hypertension International Protocol revision 2010

    Directory of Open Access Journals (Sweden)

    Takahashi H

    2013-05-01

    Full Text Available Hakuo Takahashi, Masamichi Yoshika, Toyohiko YokoiDepartment of Clinical Sciences and Laboratory Medicine, Kansai Medical University, Hirakata, Osaka, JapanBackground: Allowing patients to measure their blood pressure at home is recognized as being of clinical value. However, it is not known how often these measurements are taken correctly. Blood pressure monitors for home use fall into two types based on the position of the cuff, ie, at the upper arm or the wrist. The latter is particularly convenient, as measurements can be taken fully clothed. This study aimed to evaluate the performance of the wrist-type blood pressure monitors Omron RS8 (HEM-6310F-E, Omron RS6 (HEM-6221-E, and Omron RS3 (HEM-6130-E.Methods: A team of three trained doctors validated the performance of these devices by comparing the measurements obtained from these devices with those taken using a standard mercury sphygmomanometer. All the devices met the validation requirements of the European Society of Hypertension International Protocol revision 2010.Results: The difference in blood pressure readings between the tested device and the standard mercury sphygmomanometer was within 3 mmHg, which is acceptable according to the European Society of Hypertension guidelines.Conclusion: All the home devices tested were found to be suitable for measuring blood pressure at home because their performance fulfilled the requirement of the guidelines.Keywords: blood pressure, device, European Society of Hypertension, guideline, measurement, validation

  9. Design of CAN bus/RS232 interface%CAN总线/RS232接口的设计

    Institute of Scientific and Technical Information of China (English)

    赵杰; 刘伟静; 孙慧佳; 李楠

    2008-01-01

    采用独立CAN控制器SJA1000作为CAN总线/RS232智能电平转换器的核心器件.介绍了SJA1000器件性能,重点介绍节点硬件设计,基于CAN协议栈的节点应用程序设计,软件包括CAN节点初始化、RS232报文发送、RS232报文接收、CAN报文发送和CAN报文接收,并在Keil C51编译器上编译、调试,大大提高了系统设计的实用性.

  10. Performance Study of RS (255, 239 and RS (255.233 Used Respectively in DVB-T and NASA

    Directory of Open Access Journals (Sweden)

    Hajri Abdesslam

    2016-11-01

    Full Text Available The error correction codes have a wide range of applications in digital communication (satellite, wireless and digital data storage. This paper presents a comparative study of performance between RS (255, 239 and RS (255.233 used respectively in the Digital Video Broadcasting – Terrestrial (DVB-T and National Aeronautics and Space Administration (NASA. The performances were evaluated by applying modulation scheme in additive white Gaussian noise (AWGN channel. Performances of modulation with RS codes are evaluated in bit error rate (BER and signal energy -to- noise power density ratio (Eb / No. The analysis is studied with the help of MATLAB simulator to analyze a communication link with AWGN Channel, and different modulations.

  11. Is there the radion in the RS2 model ?

    CERN Document Server

    Smolyakov, M N; Smolyakov, Mikhail N.; Volobuev, Igor P.

    2004-01-01

    We analyse the physical boundary conditions at infinity for metric fluctuations and gauge functions in the RS2 model with matter on the brane. We argue that due to these boundary conditions the radion field cannot be gauged out in this case. Thus, it represents a physical degree of freedom of the model.

  12. Work in Progress: The Seven Rs of Team Building

    Science.gov (United States)

    Brunelli, Jean; Schneider, Elaine Fogel

    2004-01-01

    This article argues that supportive teams--including professionals, paraprofessionals, and parents--can teach staff members how to identify and implement best practices in early intervention settings. The authors describe "the seven Rs of team building" distilled from their many years of team building and maintenance: 1) Reading cues; 2) Regular…

  13. RS Components推出PCB转换器模块

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    RS Components(RS)宣布为SketchUp工具推出其新版PCB Converter(印刷电路板文件转换模块),便于设计人员将中间数据格式(Intermediate Data Format,IDF)文件输入到Google SketchUp内。

  14. 7q21-rs6964587 and breast cancer risk

    DEFF Research Database (Denmark)

    Milne, Roger L; Lorenzo-Bermejo, Justo; Burwinkel, Barbara

    2011-01-01

    Using the Breast Cancer Association Consortium, the authors previously reported that the single nucleotide polymorphism 7q21-rs6964587 (AKAP9-M463I) is associated with breast cancer risk. The authors have now assessed this association more comprehensively using 16 independent case-control studies....

  15. Rescaled range (R/S) analysis on seismic activity parameters

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The rescaled range (R/S) analysis, proposed by Hurst, is a newstatistical method. Being different from traditional statistical method, R/S analysis can provide the information of maximum fluctuation (range) of statistical parame-ters. At present paper, several modern instrumental earthquake catalogues in different spatial scale, temporal scale, and with different seismic activity background are studied, and R/S method is used to analyze the variation of range of seismic parameters such as earthquake frequency, and earthquake time interval. For different seismic parameters, the ratio of range to standard deviation - R/S is a power law function of the length of time, and the exponent H of power law is always greater than 0.5. As we know, H=0.5 is the characteristics of all ideal random processes. Our results indicate that earthquake series is not an ideal Poisson process, on the contrary, the earth-quake as a phenomenon bears dual characteristics of randomicity and regularity, and the greater H departs from 0.5, the more regularity the time series will show, and vice versa. With time scale changing, one can give the conserva-tive estimate of the fluctuation, which might occur in a relatively long time scale, only by using the limited and known time records.

  16. CAT bags orders worth Rs 90 Crore from EU

    CERN Multimedia

    2002-01-01

    "Orders to the tune of Rs 90 crore have been received by Indore-based Centre for Advanced Technology (CAT) from laboratories in the European Union (EU) and more orders are likely to follow in the near future, according to Pune-based Patel Analog and Digital Measurement Company (PADMCO) director Madhu Patel" (1/2 page).

  17. iNOS基因rs10459953/rs1060822多态性与低氧训练效果的关联性研究%Association between polymorphisms rs10459953/rs1060822 gene and variation in response to hypoxia training

    Institute of Scientific and Technical Information of China (English)

    毛颖颖; 汪洪波; 刘海平

    2014-01-01

    目的:选取低氧反应基因——诱导型一氧化氮合酶(inducible nitric oxide synthase,iN-OS)基因序列上rs10459953、rs1060822单核苷酸多态性(single nucleotide polymorphism,SNP)位点,研究其与低氧训练后生理表型指标关联性.方法:采用关联研究方法(Association-Study),聚合酶链反应-限制片段长度多态性(PCR-RFLP)实验解析技术,选取35名健康受试者在模拟海拔2500 m高度进行4周高住-高练-低训(living high-exercise high-training low,Hi-Hi-Lo).研究iNOS基因SNP rs10459953和SNPrs1060822与低氧训练后最大摄氧量(maximal oxygen uptake,VO2 max)、血红蛋白(hemoglobin,Hb)、红细胞数(red blood cell,RBC)等生理表型指标关联性.结果:1)4周低氧训练后,SNP rs10459953不同基因型之间VO2 max、Hb、RBC变化量均无显著性差异.2)4周低氧训练后,SNP rs1060822不同基因型间Hb、RBC变化量有统计学意义(P<0.05),其中CT基因型受试者Hb、RBC显著增加(P<0.05),且在低氧环境下定量负荷实验中,SNP rs1060822的CT基因型受试者低氧训练后期SpO2动态曲线显著高于初期(P<0.05).结论:iNOS基因SNP rs1060822与低氧训练后血象指标存在一定关联性,CT基因型表现出一定优势.

  18. Reassessment and new chronological data (Ar/Ar, Rb/Sr and Sm/Nd) from the Pelotas batholith, Rio Grande do Sul state: petrogenesis implications and reactivation age of the shear zones; Reavaliacao e novos dados geocronologicos (Ar/Ar, Rb/Sr e Sm/Nd) do batolito Pelotas, no Rio Grande do Sul: implicacoes petrogeneticas e idade de reativacao das zonas de cisalhamento

    Energy Technology Data Exchange (ETDEWEB)

    Philipp, Ruy Paulo; Chemale Junior, Farid [Rio Grande do Sul Univ., Porto Alegre (Brazil). Inst. de Geociencias. Centro de Estudos em Petrologia e Geoquimica]. E-mail: ruy.philipp@ufrgs.br; Machado, Romulo [Sao Paulo Univ., SP (Brazil). Inst. de Geociencias. Dept. de Mineralogia e Geotectonica

    2003-08-15

    SHRIMP and conventional U-Pb and Pb/Pb evaporation dating of zircon from the Pelotas batholith indicates one group of ages between 625 and 633 Ma for the Pinheiro Machado suite, and another group between 575 and 599 Ma for the Viamao, Encruzilhada do Sul and Dom Feliciano suites. Sr 87/Sr 86 isotopic ratios of 0.7060-0.7016, epsilon{sub Nd} values of -5 and -10, and Nd T{sub DM} model ages between 2200 and 1600 Ma suggest that the suites were mainly derived by melting of Paleoproterozoic crust formed during the Tranzamazonic Cycle. Basic magmatism and heterogeneous magma mixing in the Pinheiro Machado, Viamao, Encruzilhada do Sul and Dom Feliciano suite and the Piquiri alkaline magmatism, with Pb/Pb zircon evaporation ages between 610 and 615 Ma, suggest that a mantle component also contributed to the formation of the Pelotas batholith. 39 Ar/40 Ar determinations in micas from mylonitic rocks of high- and low-dip shear zones showed ages between 540 and 530 Ma, which show that important tectonic events occurred after the emplacement of the batholith. This event developed in a transpressive regime, was responsible for the reactivation of older shear zones, and was probably contemporaneous with the development of the Camaqua basin. (author)

  19. Trends in socioeconomic inequalities in anthropometric status in a population undergoing the nutritional transition: data from 1982, 1993 and 2004 pelotas birth cohort studies

    Directory of Open Access Journals (Sweden)

    Matijasevich Alicia

    2012-07-01

    Full Text Available Abstract Background Socioeconomic inequalities in child nutrition may change rapidly over time, particularly in populations undergoing the nutrition transition. Yet, the few available studies are repeated cross-sectional surveys. By studying three prospective birth cohorts in the same city over a period of more than two decades, we describe secular trends in overweight and stunting at different ages, according to socioeconomic position. Methods Population-based birth cohort studies were launched in the city of Pelotas (Brazil in 1982, 1993 and 2004, with follow-up visits at twelve, 24 and 48 months. Children were weighed and measured at every visit. Z-scores of length/height-for-age and body mass index-for-age were calculated using the WHO Child Growth Standards. The slope and relative indices of inequality, based on family income quintiles, were estimated for each follow-up visit. Results Between the 1982 and 2004 cohorts, stunting among four-year-olds declined (from 10.9% to 3.6%, while overweight increased (from 7.6% to 12.3%. In every visit, stunting prevalence was inversely related to income. Both absolute and relative inequalities declined over time; among four-year-olds stunting dropped from 26.0% in the 1982 cohort to 6.7% in the 2004 cohort in the poorest group, while in the richest group stunting prevalence dropped from 2.7% in 1982 to 1.1% in the 2004 cohort study. The secular trend towards increased overweight was evident for four-year-olds, in almost all socioeconomic groups, but not among one and two-year-olds. Among four-year old children, overweight prevalence increased in all income quintiles, by 130% in the middle-income group, 64% in the poorest and 41% in the richest group. Conclusions The decline in stunting is remarkable, but the increase in overweight among four-year olds – particularly among the poorest and the middle-income groups– requires concerted efforts to prevent the long term consequences of child overweight.

  20. Association of rs10757274 and rs2383206 Polymorphisms on 9p21 locus with Coronary Artery Disease in Turkish Population

    Science.gov (United States)

    Okyay, Kaan; Yılmaz, Akın; Şahinarslan, Asife; Yar Sağlam, Atiye Seda; Eyiol, Azmi; Bolayır, Hasan Ata; Sezenöz, Burak; Menevşe, Sevda; Çengel, Atiye

    2016-01-01

    Background and Objectives Genetic predisposition is an important risk factor for coronary artery disease (CAD). In this study, we aimed to evaluate the impact of rs10757274 and rs2383206 polymorphisms in chromosome 9p21 on presence and severity of CAD in a Turkish population. Subjects and Methods A total of 646 patients who underwent coronary angiography were included in this study. Coronary vessel score and Gensini score were calculated to assess the angiographic severity of CAD. Alleles of AA, AG, and GG were determined for rs10757274 (polymorphism-1) and rs2383206 (polymorphism-2) polymorphisms located in chromosome 9p21 from the blood samples. Results There was a significant difference between the alleles in polymorphism-1 in the presence of coronary artery disease (38.9% in AA, 48.0% in GG and 56.4% in AG, p=0.017). However, there was no difference between the alleles in polymorphism-2. According to vessel scores, there was a significant difference between the alleles in polymorphism-1 (AA 0.71±1.04, GG 0.88±1.07, AG 1.06±1.12, p=0.018). In polymorphism-2, vessel scores did not show a difference between the alleles. In polymorphism-1, there was a significant difference in Gensini score (p=0.041). Gensini scores did not differ between the alleles in polymorphism-2 (p>0.05 for all). In multivariate analyses, none of the alleles was an independent factor for presence of CAD. Conclusion The presence of rs10757274 polymorphism including AG allele in chromosome 9p21 was related to CAD. However, this relationship was not independent of other cardiovascular risk factors. PMID:27721851

  1. single nucleotide Polymorphisms rs2227284, rs2243283 and rs2243288 in the Il-4 Gene show no association with susceptibility to Chronic Hepatitis B in a Chinese Han Population

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    Objective To investigate the relationship between single nucleotide polymorphisms (SNPs) of the interleukin-4 (IL-4) gene and outcome of hepatitis B virus (HBV) infection in a Chinese Han population. Methods Total of 501 patients with chronic hepatitis B virus (HBV) infection and 301 controls with self-limiting HBV infection were studied. Three tag SNPs in the IL-4 gene (rs2227284G/T, rs2243283C/G and rs2243288A/G) were genotyped by the Multiplex snapshot technique. The genotype and allele frequencies were calculated and analyzed. Results The three SNPs showed no significant genotype/allele associations with chronic HBV infection. Overall allele P values were:rs2227284, P=0.655, odds ratio (OR) [95%conifdence interval (CI)]=1.070 (0.793-1.445);rs2243283, P=0.849, OR (95%CI)=0.976 (0.758-1.257);rs2243288, P=0.659, OR (95%CI) = 1.060 (0.818-1.375). Overall genotype P values were: rs2227284, P = 0.771; rs2243283, P = 0.571;rs2243288, P=0.902. There were no statistically signiifcant differences between patients with chronic HBV infection and controls. Haplotypes generated by these three SNPs also had no signiifcant differences between the two groups. Conclusions The three tag SNPs of IL-4 were not associated with the outcome of HBV infection in the Han Chinese population.

  2. Predicting pKa for proteins using COSMO-RS

    DEFF Research Database (Denmark)

    Andersson, Martin Peter; Jensen, Jan Halborg; Stipp, Susan Louise Svane

    2013-01-01

    We have used the COSMO-RS implicit solvation method to calculate the equilibrium constants, pKa, for deprotonation of the acidic residues of the ovomucoid inhibitor protein, OMTKY3. The root mean square error for comparison with experimental data is only 0.5 pH units and the maximum error 0.8 p......H units. The results show that the accuracy of pKa prediction using COSMO-RS is as good for large biomolecules as it is for smaller inorganic and organic acids and that the method compares very well to previous pKa predictions of the OMTKY3 protein using Quantum Mechanics/Molecular Mechanics. Our approach...

  3. AS/RS based yard and yard planning

    Institute of Scientific and Technical Information of China (English)

    Ya-hong HU; Zheng-dong ZHU; Wen-jing HSU

    2008-01-01

    In this paper,we apply the split-platform automated storage/retrieval systems (SP-AS/RSs) (Hu et al.,2005) to store containers in the yard to improve the yard performance and to increase the utilization of the yard space.The layout of an SP-AS/RS based yard is described in detail.To achieve an efficient operation,we present a novel yard space allocation policy called the 'second-carrier-based allocation policy',which can help to alleviate the out-of-sequence problem of containers and the congestion of vehicles at the AS/RS racks.Different allocation policies are compared by an integrated container terminal simulation system.The simulation results show that the second-carrier-based policy is very efficient and has the potential to offer high terminal performance.

  4. RS232-GPIB控制器的设计

    Institute of Scientific and Technical Information of China (English)

    黄君凯; 吴延军

    2006-01-01

    描述了基于RS232接口的GPIB控制器的设计,利用单片机控制GPIB接口芯片NAT9914,并通过SCPI语句在Windows操作系统自带的串口通信工具超级终端中,实现了计算机与GPIB仪器的通信与程控.

  5. RS232到并行数据变换

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@ 标准IC可变换RS232格式到8位并行数据(带一个起始和终止位).整个成本和功耗低于任何可用的标准芯片. 此电路(见图1)可做为PC基串行接口(经COM1或COM2端口)的一部分.

  6. R.S. Peters' Comprehensive Theory of Moral Education

    OpenAIRE

    2014-01-01

    This article presents R.S. Peters’ theory of moral education embedded in his broad conception of morality. The author examines Peters’ views against the background of Kohlberg’s stage theory of moral development; hence, the positions of both thinkers are interwoven throughout the discussion. It addresses some central issues relevant to moral education such as, for example: cognitive and affective aspects of morality, and the acquisition of virtues. In the article the author argues that Peters...

  7. Association of vitamin D receptor BsmI (rs1544410), Fok1 (rs2228570), TaqI (rs731236) and ApaI (rs7975232) gene polymorphism with the nephrolithiasis susceptibility.

    Science.gov (United States)

    Zhou, Tian-Biao; Jiang, Zong-Pei; Li, Ai-Hua; Ju, Lang

    2015-04-01

    Association of vitamin D receptor (VDR) gene polymorphism with the risk of nephrolithiasis from the published reports is still conflicting. This study was conducted to evaluate the relationship between VDR BsmI (rs1544410), Fok1 (rs2228570), TaqI (rs731236) and ApaI (rs7975232) gene polymorphism and the risk of nephrolithiasis using meta-analysis method. The association studies were identified from PubMed, and Cochrane Library on 1 April 2014, and eligible investigations were included and synthesized using meta-analysis method. Six reports were recruited into this meta-analysis for the association of VDR BsmI, Fok1, TaqI and ApaI gene polymorphism with nephrolithiasis susceptibility. In this meta-analysis, VDR BsmI, Fok1, TaqI and ApaI gene polymorphism were not associated with nephrolithiasis susceptibility for overall populations and in Caucasians. However, the Fok1 f allele and ff genotype were associated with the risk of nephrolithiasis in Asians, but the FF genotype not. Furthermore, TaqI TT genotype was associated with the risk of nephrolithiasis in Asians, but the t allele and tt genotype not. However, ApaI gene polymorphism was not associated with nephrolithiasis susceptibility in Asians. In conclusion, VDR BsmI, Fok1, TaqI and ApaI gene polymorphism were not associated with nephrolithiasis risk in overall populations and in Caucasians. But, the Fok1 f allele and ff genotype, TaqI TT genotype, ApaI gene polymorphism were associated with the risk of nephrolithiasis in Asians. However, more studies should be conducted to confirm it.

  8. Převodník Ethernet na RS-232

    OpenAIRE

    Dreiseitel, Jiří

    2012-01-01

    Práce je věnována problematice konstrukce převodníku Ethernet na RS-232 za pomocí jednočipového mikrokontroléru. Cílem je seznámit čtenáře se síťovou technologií Ethernet a technologií pro sériový přenos založený na protokolu RS-232 a zároveň s technologií vestavěných systémů pro konstrukci zařízení.Součástí práce je kompletní návrh převodníku Ethernet na RS-232 včetně návrhu a implementace firmware v jazyce C za využití LwIP TCP/IP stacku. Převodník je postaven na základě vývojového kitu STM...

  9. Alkaline protease from Thermoactinomyces sp. RS1 mitigates industrial pollution.

    Science.gov (United States)

    Verma, Amit; Ansari, Mohammad W; Anwar, Mohmmad S; Agrawal, Ruchi; Agrawal, Sanjeev

    2014-05-01

    Proteases have found a wide application in the several industrial processes, such as laundry detergents, protein recovery or solubilization, prion degradation, meat tenderizations, and in bating of hides and skins in leather industries. But the main hurdle in industrial application of proteases is their economical production on a large scale. The present investigation aimed to exploit the locally available inexpensive agricultural and household wastes for alkaline protease production using Thermoactinomyces sp. RS1 via solid-state fermentation (SSF) technique. The alkaline enzyme is potentially useful as an additive in commercial detergents to mitigate pollution load due to extensive use of caustic soda-based detergents. Thermoactinomyces sp. RS1 showed good protease production under SSF conditions of 55 °C, pH 9, and 50 % moisture content with potato peels as solid substrate. The presented findings revealed that crude alkaline protease produced by Thermoactinomyces sp. RS1 via SSF is of potential application in silver recovery from used X-ray films.

  10. Metallicity and effective temperature of the secondary of RS Oph

    CERN Document Server

    Pavlenko, Ya V; Kerr, T; Yakovina, L; Woodward, C E; Lynch, D; Rudy, R; Pearson, R L; Russell, R W

    2008-01-01

    The recurrent nova RS Oph undergoes nova eruptions every ~ 10-20years as a result of thermonuclear runaway on the surface of a white dwarf close to the Chandrasekhar limit. Both the progress of the eruption, and its aftermath, depend on the (poorly known) composition of the red giant in the RS Oph system. Our aim is to understand better the effect of the giant secondary on the recurrent nova eruption. Synthetic spectra were computed for a grid of M-giant model atmospheres having a range of effective temperatures 3200 < Teff < 4400 K, gravities 0 < log g < 1 and abundances -4 <[Fe/H] < 0.5, and fit to infrared spectra of RS Oph as it returned to quiescence after its 2006 eruption. We have modelled the infrared spectrum in the range 1.4-2.5 micron to determine metallicity and effective temperature of the red giant. We find Teff = 4100 +/- 100 K, log g = 0.0 +/- 0.5, [Fe/H] = 0.0 +/- 0.5, [C/H] = -0.8 +/- 0.2, [N/H] = +0.6 +/- 0.3 in the atmosphere of the secondary, and demonstrate that that in...

  11. Creating and maintaining social networks: women’s participation in Basque pilota. [Creación y mantenimiento de redes sociales: participación de mujeres en pelota vasca].

    Directory of Open Access Journals (Sweden)

    Uxue Fernandez-Lasa

    2015-04-01

    Full Text Available Basque pilota is a traditional sport played mainly by men. A project emerged in 2005 to promote female participation: Emakumea Pilotari (Woman pelota player. In this article we present the main points that emerged from an ethnographic study of the social relationships that playing Basque pilota can provide. The study was carried out in 2011-2012 season with a purposive sample of 28 adult women Basque pilota players (pilotaris (between 22 and 60 years old. 26 participants were pilotaris in recreational groups and the other two were their trainers. The results suggest that a sense of community, team membership, the development of a general reciprocity and group security are the most important aspects for players. A sense of community is the fundamental reason why they practise this sport. The group as a whole is the top priority. Female pilotaris share the desire to relate to each other as women, build relationships, create bonds and help each other. Resumen La pelota vasca es un deporte tradicional practicado mayoritariamente por hombres. En 2005 se puso en marcha un proyecto para promover la participación de las mujeres: Emakumea Pilotari (Mujer Pelotari. En este artículo se presentan los hallazgos de un estudio etnográfico llevado a cabo durante una temporada en torno a las relaciones sociales que genera jugar a pelota vasca. La investigación se realizó con una muestra intencionada de 28 mujeres pelotaris adultas (entre 22 y 60 años, de las cuales 26 eran participantes de un programa recreativo y dos entrenadoras. Los resultados indican que los aspectos más importantes para las participantes son el sentimiento de comunidad, ser miembro de un grupo, el desarrollo de la reciprocidad general y la seguridad que da el grupo. La comunidad es la razón fundamental para practicar este deporte, ya que el grupo es la mayor prioridad. Las mujeres pelotaris comparten el deseo de relacionarse entre ellas como mujeres, construir relaciones, crear

  12. Validation of the Edinburgh Postnatal Depression Scale (EPDS in a sample of mothers from the 2004 Pelotas Birth Cohort Study Validação da Escala de Depressão Pós-natal de Edinburgo (EPDS em uma amostra de mães da Coorte de Nascimento de Pelotas, 2004

    Directory of Open Access Journals (Sweden)

    Iná S. Santos

    2007-11-01

    Full Text Available The aim of this study was to evaluate the Edinburgh Postnatal Depression Scale (EPDS for screening and diagnosis of postpartum depression. Three months after delivery, EPDS was administered to 378 mothers from the 2004 Pelotas Birth Cohort Study, Rio Grande do Sul State, Brazil. Up to 15 days later, mothers were re-interviewed by mental health care professionals using a semi-structured interview based on ICD-10 (gold standard. We calculated the sensitivity and specificity of each cutoff point, and values were plotted as a receiver operator characteristic curve. The best cutoff point for screening postpartum depression was > 10, with 82.6% (75.3-89.9% sensitivity and 65.4% (59.8-71.1% specificity. For screening moderate and severe cases, the best cutoff point was > 11, with 83.8% (73.4-91.3% sensitivity and 74.7% (69.4-79.5% specificity. For diagnosis, EPDS was valid only for prevalence of postpartum depression in the 20-25% range, with 60% PPV for the > 13 cutoff point (59.5% sensitivity; 88.4% specificity. The specificities and PPVs for all cutoff points were below those reported by other authors. Small numbers and the calculation of PPV in samples with overrepresentation of cases in the majority of studies appear to account for these differences.Avaliar a validade da Escala de Depressão Pós-natal de Edimburgo (EPDS para rastreamento e diagnóstico de depressão pós-parto. Três meses pós-parto, a EPDS foi aplicada a 378 mães da Coorte de Nascimentos de Pelotas, Rio Grande do Sul, Brasil, em 2004. Até 15 dias após, as mães foram reentrevistadas por profissionais de saúde mental utilizando-se questionário semi-estruturado baseado na CID-10 (padrão-ouro. Calculamos sensibilidade e especificidade de cada ponto de corte e construiu-se curva ROC. Melhor ponto de corte para rastreamento foi > 10 (sensibilidade 82,6%, 75,3%-89,9%; especificidade 65,4%, 59,8%-71,1%. Para rastrear casos moderados e graves, melhor ponto de corte foi > 11, com

  13. Utilização de adoçantes dietéticos entre adultos em Pelotas, Rio Grande do Sul, Brasil: um estudo de base populacional Use of diet sweeteners by adults in Pelotas, Rio Grande do Sul State, Brazil: a population-based study

    Directory of Open Access Journals (Sweden)

    Roberta de Vargas Zanini

    2011-05-01

    Full Text Available Estudo de base populacional avaliou o uso de adoçantes dietéticos na população com idade ≥ 20 anos, residente na zona urbana do Município de Pelotas, Rio Grande do Sul, Brasil. A coleta de dados ocorreu entre janeiro e julho de 2010, e 2.732 indivíduos foram entrevistados. Além das questões específicas quanto ao uso de adoçante dietético, foram coletadas informações sobre características demográficas, socioeconômicas e de saúde. Para as análises estatísticas, foram utilizados testes qui-quadrado de heterogeneidade e de tendência linear. A prevalência de uso de adoçante dietético foi 19% (IC95%: 17,1; 20,9, sendo 3,7 vezes maior entre idosos do que entre aqueles com 20-29 anos de idade. Nível econômico e estado nutricional apresentaram associação direta e significativa com o desfecho. Quase 98% da amostra utilizou adoçantes na forma líquida, sendo os mais consumidos (89,2% aqueles constituídos por sacarina e ciclamato de sódio. A mediana de ingestão diária foi 10 gotas (P25; P75 = 6; 18, entre usuários de adoçante líquido, ou 1,5 sachet (P25; P75 = 1; 4, para adoçante em pó. O uso de adoçante dietético foi maior entre mulheres e idosos.This population-based study evaluated the use of diet sweeteners by adults (> 20 years in Pelotas, Rio Grande do Sul State, Brazil. Data were collected from January to July 2010 (n = 2,732. Besides specific questions on diet sweeteners, demographic, socioeconomic, and health characteristics were recorded. Heterogeneity and linear trend chi-square tests were used for the statistical analysis. Prevalence of sweetener use was 19% (95%CI: 1.1-20.9, and was 3.7 times higher in elderly individuals as compared to 20-29-year-olds. Economic level and nutritional status were significantly associated with sweetener use. Nearly 98% of the sample used liquid sweeteners; the most frequently consumed (89.2% were those containing saccharin or sodium cyclamate. Average intake was 10 drops

  14. 中国回族人群SNP rs445251和rs1523537遗传多态性

    Institute of Scientific and Technical Information of China (English)

    冯婷; 李淑瑾; 丛斌; 娄春光

    2011-01-01

    @@ 由于单核苷酸(single nucleotide polymorphisms, SNP)具有广泛存在于基因组中,突变率低及扩增产物长度可小于100bp等优点[1],是法医实践中亲子鉴定和个人识别的重要遗传标记,也适合于高度降解检材的检测.本文采用磷酸测序技术(pyrosequencing)这一新型DNA测序技术[2-3],对中国回族人群SNP基因座rs445251和rs1523537进行基因频率调查,以期为建立法医SNP分型提供基础数据.

  15. RS-485 Communication Interface Chip With FPGA%用FPGA实现RS-485通信接口芯片

    Institute of Scientific and Technical Information of China (English)

    梁士龙; 王力男; 杨嘉伟

    2002-01-01

    在点对多点主从通信系统中,需要合适的接口形式和通信协议实现主站与各从站的信息交换.RS-485接口是适合这种需求的一种标准接口形式.当选择主从多点同步通信方式时,工作过程与帧格式符合HDLC/SDLC协议.介绍了采用VHDL语言在FPGA上实现的以HDLC/SDLC协议控制为基础的RS-485通信接口芯片.实验表明,这种接口芯片操作简单、体积小、功耗低、可靠性高,极具实用价值.

  16. [Anorexia nervosa with refeeding syndrome: prevention and treatment of RS].

    Science.gov (United States)

    Kasai, Makiko; Okajima, Yoshirou; Takano, Eisuke; Kato, Satoshi

    2009-01-01

    Refeeding syndrome (RS), seen in the early stages of anorexia nervosa (AN) treatment, has not been paid sufficient attention regarding its strong association with poor outcomes. This report describes a case of AN restriction type (AN-R) with sequent RS appearance despite the introduction of progressive and careful low-calorie nutrition, and discusses RS treatment. The patient was a 16-year-old female. She was first diagnosed with AN at the age of 14 when she went on a diet, admitted into pediatrics, and recovered: however, AN recurred after she started high school, and her weight decreased to 31.8 kg. She was admitted to pediatrics again, refused to receive treatment, discharged from the hospital, and introduced to our department. Soon after she came to us, her weight went down to 29.6 kg, and continued to decrease to 26.8 kg. She was recommended to receive inpatient care, but she firmly refused. A few days later, her experience of loss of consciousness made her agree to receive inpatient care. At this time, she was already weakened and had difficulty performing voluntary body movements as well as excretion. She was treated carefully and placed on 125 kcal/day. On the 6th day of treatment, severe liver damage was observed, her serum phosphorus level went down to 2.0 mg/dL, and she was diagnosed with RS. The lowest concentration of serum phosphorus observed was 1.3 mg/dL with blood abnormality and delirium; however, our strict management with intravascular phosphorus administration supported her increased dietary intake, and the patient was able to leave the hospital on the 54th day after admission. Based on this experience, the pathogenesis of RS was overviewed, and RS prevention as well as treatment was discussed. It has been reported that low phosphorus levels are observed in approximately one quarter of AN patients, and, thus, immediate action and treatment of hypophosphatemia are necessary when considering RS occurrence. In this study, the observed serum

  17. Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development: an updated meta-analysis

    Science.gov (United States)

    Dai, Zhi-Ming; Zhang, Tian-Song; Lin, Shuai; Zhang, Wang-Gang; Liu, Jie; Cao, Xing-Mei; Li, Hong-Bao; Wang, Meng; Liu, Xing-Han; Liu, Kang; Li, Shan-Li; Dai, Zhi-Jun

    2016-01-01

    Single nucleotide polymorphisms (SNPs) in the interleukin-17 (IL-17) gene have been shown to be correlated with susceptibility to cancer. However, various studies report different results of this association. The aim of the present work was to clarify the effects of IL-17A G197A (rs2275913) and IL-17F T7488C (rs763780) polymorphisms on cancer risk. We performed systematic searches of the PubMed and CNKI databases to obtain relevant publications. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association of rs2275913 and rs763780 polymorphisms with cancer risk. Data were extracted from the selected studies, and statistical analysis was conducted using the STATA software. Our results indicated that rs2275913 and rs763780 polymorphisms significantly increase cancer risk, especially in gastric cancers. Subgroup analysis suggested the existence of a significant correlation between rs763780 polymorphism and cancer susceptibility in Caucasian populations. This updated meta-analysis confirms that rs2275913 and rs763780 polymorphisms are highly associated with increased risk for multiple forms of cancer. PMID:26843459

  18. RS232口获取+5 V电源%How to Get +5 V Power Source from RS232 Interface

    Institute of Scientific and Technical Information of China (English)

    符沧海

    2000-01-01

    由于RS232通信接口协议简单,工业控制系统已广泛应用RS232口对各种设备进行信号采集和控制.为了降低成本,缩小体积,这些输入输出设备可直接从RS232口获取控制电路所需的+5 V电源.文中介绍了从RS232口得到+5 V电源的几种变换电路.

  19. Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility

    Directory of Open Access Journals (Sweden)

    Qing Ni

    2015-01-01

    Full Text Available Background. Single nucleotide polymorphisms (SNPs in genes encoding microRNAs may play important role in the development of gastric cancer. It has been reported that common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to gastric cancer. The published results remain inconclusive or even controversial. A meta-analysis was conducted to quantitatively assess potential association between the two common SNPs and gastric cancer risk. Methods. A comprehensive literature search was performed in multiple internet-based electronic databases. Data from 12 eligible studies were extracted to estimate pooled odds ratios (ORs and 95% confidence intervals (95% CI. Results. C allele of rs2910164 is associated with reduced gastric cancer risk in heterozygote model and dominant model whereas rs11614913 indicates no significant association. Subgroup analysis demonstrates that C allele of rs2910164 and rs11614913 may decrease susceptibility to diffuse type gastric cancer in dominant model and recessive model, respectively, while rs11614913 increased intestinal type gastric cancer in dominant model. Conclusion. SNPs rs2910164 and rs11614913 might have effect on gastric cancer risk in certain genetic models and specific types of cancer. Further well-designed studies should be considered to validate the potential effect.

  20. Avaliação da utilização de diferentes materiais para diminuição da tendência de colagem de pelotas durante o processo de redução direta

    OpenAIRE

    Jose Geraldo Pereira

    2012-01-01

    O processo de obtenção de ferro metálico por redução direta de minério de ferro possui grande importância no cenário siderúrgico e tem evoluído tecnologicamente de forma expressiva nas últimas décadas. Um grande entrave a essa evolução é, reconhecidamente, a formação de cachos por colagem das pelotas durante redução, que diminui a permeabilidade dos gases através do leito, afetando o desempenho do reator. Vários estudos abordaram o tema e se complementam na descrição do fenômeno de colagem...

  1. rs6983267和rs1447295与北京地区前列腺癌的关联研究%Association between rs6983267 and rs1447295 and the risk of prostate cancer in Beijing Han population

    Institute of Scientific and Technical Information of China (English)

    蒲连美; 刘铭; 史晓红; 魏东; 王建业; 杨泽

    2012-01-01

    OBJECTIVE: To investigate the association of the two common single nucleotide polymorphisms (SNPs, rs6983267 and rsl447295) on chromosome 8q24 with the susceptibility of prostate cancer (PCs) in Beijing Han population. METHODS: Using a case-control design, 154 PCa patients and 138 cancer-free healthy subjects were included The distribution of allele and genotype frequencies of the SNPs rs6983267 and rsl447295 was detected with the polymerase chain reaction-high resolution melting curve (PCR-HRM) combined with gene sequencing,and analyzed the cumulative effect of risk genotypes of these two SNPs. RESULTS: AS for the genotypes of rs6983267,the distribution in the PCa group was as follow:33. 1% TT.46. 4% GT,20. 5% GG.as compared with 32. 6%,48. 5% and 18.9% in the healthy controls. As regards the genotypes of rsl447295, there were 3. 3% AA.38. 2% AC and 58. 6% CC in the PCa patients,in comparison with 1. 5% ,32.1% and 66. 4% in the controls. No significant difference was observed between these two SNPs and the risk of PCa(P>0. 05). And although results were not any statistically significant,men who carried one or two risk genotypes had a increased risk by 1. 231 times and 1. 571 times respectively,compared with men without any risk genotypes(P>0. 05). CONCLUSION: SNPs rs6983267 and rsl447295 on chromosome 8q24 might not be correlated with PCa in Beijing Han population.%目的:探讨染色体8q24两个单核苷酸多态性位点(SNPs) rs6983267和rs1447295,与北京地区前列腺癌(PCa)的相关性.方法:采用病例-对照研究,入选了154例PCa患者和138名正常对照者,检测2个SNPs在病例组和对照组间的等位基因及基因型的分布情况,并分析危险基因型的累积效应.结果:rs6983267有TT、GT及GG 3种基因型,在病例组的分布分别为33.1%、46.4%及20.5%,在对照组的分布分别为32.6%、48.5%及18.9%;rs1447295也有AA、AC及CC 3种基因型,在病例组的分布分别为3.3%、38.2%及58.6%,在

  2. Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795, and ACSL1 rs6552828

    Science.gov (United States)

    Fuku, Noriyuki; He, Zi-hong; Sanchis-Gomar, Fabian; Pareja-Galeano, Helios; Tian, Ye; Arai, Yasumichi; Abe, Yukiko; Murakami, Haruka; Miyachi, Motohiko; Zempo, Hirofumi; Naito, Hisashi; Yvert, Thomas; Verde, Zoraida; Venturini, Letizia; Fiuza-Luces, Carmen; Santos-Lozano, Alejandro; Rodriguez-Romo, Gabriel; Ricevuti, Giovanni; Hirose, Nobuyoshi; Emanuele, Enzo; Garatachea, Nuria; Lucia, Alejandro

    2015-01-01

    There are several gene variants that are candidates to influence functional capacity in long-lived individuals. As such, their potential association with exceptional longevity (EL, i.e., reaching 100+ years) deserves analysis. Among them are rs7832552 in the thyrotropin-releasing hormone receptor (TRHR) gene, rs1800795 in the interleukin-6 (IL6) gene and rs6552828 in the coenzyme A synthetase long-chain 1 (ACSL1) gene. To gain insight into their functionality (which is yet unknown), here we determined for the first time luciferase gene reporter activity at the muscle tissue level in rs7832552 and rs6552828. We then compared allele/genotype frequencies of the 3 abovementioned variants among centenarians [n = 138, age range 100–111 years (114 women)] and healthy controls [n = 334, 20–50 years (141 women)] of the same ethnic and geographic origin (Spain). We also studied healthy centenarians [n = 79, 100–104 years (40 women)] and controls [n = 316, 27–81 years (156 women)] from Italy, and centenarians [n = 742, 100–116 years (623 women)] and healthy controls [n = 499, 23–59 years (356 women)] from Japan. The THRH rs7832552 T-allele and ACSL1 rs6552828 A-allele up-regulated luciferase activity compared to the C and G-allele, respectively (P = 0.001). Yet we found no significant association of EL with rs7832552, rs1800795 or rs6552828 in any of the 3 cohorts. Further research is needed with larger cohorts of centenarians of different origin as well as with younger old people. PMID:25999849

  3. RS Ophiuchi in Quiescence: Why is it X-ray Faint?

    CERN Document Server

    Mukai, Koji

    2008-01-01

    The short interval between successive outbursts of RS Oph strongly suggests that it has a high mass white dwarf accreting at a high rate. This, in turn, suggests the possibility of prominent X-ray emission from RS Oph in quiescence. However, archival quiescent X-ray observations of RS Oph show it to be a modest soft X-ray source but not a strong 2-10 keV X-ray source. In this aspect, RS Oph differs markedly from T CrB. We speculate on the possible mechanisms that could significantly suppress the 2-10 keV X-ray emission in RS Oph.

  4. Prevenção de defeitos do tubo neural: prevalência do uso da suplementação de ácido fólico e fatores associados em gestantes na cidade de Pelotas, Rio Grande do Sul, Brasil Prevention of neural tube defects: prevalence of folic acid supplementation during pregnancy and associated factors in Pelotas, Rio Grande do Sul State, Brazil

    OpenAIRE

    Cíntia Leal Sclowitz Mezzomo; Gilberto de Lima Garcias; Marcelo Leal Sclowitz; Iandora Timm Sclowitz; Clarice Brinck Brum; Tiago Fontana; Ricardo Issler Unfried

    2007-01-01

    Com o objetivo de determinar a prevalência do uso do ácido fólico e fatores associados na gestação e no período periconcepcional, realizou-se um estudo transversal de base populacional nas cinco maternidades da cidade de Pelotas, Rio Grande do Sul, Brasil. A coleta de dados ocorreu no período de 1º de abril a 15 de agosto de 2006, com 1.450 mulheres. As entrevistas foram realizadas em nível hospitalar por questionário padronizado. A análise estatística se realizou por regressão de Poisson. A ...

  5. COMPARISON OF TUNNELLING METHODS NATM AND ADECO-RS

    Directory of Open Access Journals (Sweden)

    Linda Černá Vydrová

    2015-04-01

    Full Text Available The New Austrian Tunnelling Method (NATM has been often used in the Czech Republic in last two decades. One of the methods, without application in the Czech Republic, is an Italian method called ADECO-RS, which has reached significant use in Italy and some other countries. It is the method of controlled deformation, which uses mainly the horizontal anchoring of the tunnel face to reinforce the area in front of the face (advance core. This technology is especially important in weak and soft rocks where is necessary to excavate quickly and smoothly with minimum disruption of initial stress state of the rock mass in the vicinity of the excavation. The use of NATM can be in some cases uneconomical and technically inadequately challenging and in such cases would be appropriate to choose another technology. Given the facts above, in the Czech environment there is no data available for comparison of these methods not only in terms of numerical modelling, but also in terms of feasibility and usability. The paper summarizes history of the tunnelling methods and it is closer devoted to NATM and ADECO-RS tunnelling approaches. The basic principles of both methods are set and further the comparison of these methods is made on a theoretical level. The paper hereinafter includes the analysis of fibreglass face anchors application during the construction of three-aisled Veleslavín Station and the impact assessment of tunnel face anchoring during the excavation of ventilation tunnel on the newly built part of the Prague Metro „V.A“. The paper also deals with practical knowledge gained during the technical visit of Italian Val di Sambro Tunnel which is built according to ADECO-RS approach. These findings are essential for the correct interpretation of Lunardi method.

  6. RS CVn binaries: Testing the solar-stellar dynamo connection

    Science.gov (United States)

    Dempsey, R.

    1995-01-01

    We have used the Extreme Ultraviolet Explorer satellite to study the coronal emission from the EUV-bright RS CVn binaries Sigma2 CrB, observed February 10-21, 1994, and II Peg, observed October 1-5, 1993. We present time-resolved and integrated EUV short-, medium-, and long-wavelength spectra for these binaries. Sigma2 CrB shows significant first-order emission features in the long-wavelength region. The coronal emission distributions and electron densities are estimated for those active coronae dominated by high temperature plasma.

  7. Radio polarization characteristics of two RS CVn binaries

    Science.gov (United States)

    Mutel, R. L.; Lestrade, J.-F.; Doiron, D. J.

    1985-07-01

    The authors report the results of multifrequency epoch VLA observations of polarized radio emission from the nearby active RS CVn binaries UX Arietis and HR 1099. For both systems, there is an excellent correlation between handedness of circular polarization and frequency. Helicity reversal is almost always seen between 1.4 and 5.0 GHz, possibly due to optical depth effects. There may also be an anticorrelation between total intensity and fractional circular polarization, especially at 5 GHz. This is consistent with models in which intense flares are associated with compact self-absorbed synchrotron sources, while the quiescent emission arises from larger gyrosynchrotron-emitting plasma.

  8. Swift Observations of Shock Evolution in RS Ophiuchi

    CERN Document Server

    Bode, M F; Page, K L; Beardmore, A P; O'Brien, T J; Ness, J -U; Starrfield, S; Skinner, G K; Darnley, M J; Drake, J J; Evans, A; Eyres, S P S; Krautter, J; Schwarz, G

    2008-01-01

    Our \\textit{Swift} observations of RS Oph form an unprecedented X-ray dataset to undertake investigations of both the central source and the interaction of the outburst ejecta with the circumstellar environment. Over the first month, the XRT data are dominated by emission from rapidly evolving shocks. We discuss the differences in derived parameters from those found for \\textit{RXTE} at early times and the evolution of the X-ray emission to much later times. It is apparent that at late times several emission components are present. We find no strong evidence of the proposed shock break-out in our data.

  9. PC interfacing using Centronics, RS232 and game ports

    CERN Document Server

    An, Pei

    1998-01-01

    The main links with your PC and the outside world are the centronic port, used for connecting the printer, the RS232 port, used for the mouse, and the games port for a joystick. This book explores how these input/output (I/O) ports can be put to use through a range of other interfacing applications. This is especially useful for laptop and palmtop PCs which cannot be fitted with internal I/O cards. A novel approach is taken by this book, combining the hardware through which the ports can be explored, and the software programming needed to carry out a range of experiments.Circuits are p

  10. Role of IL-8 rs4073 and rs2227306 polymorphisms in the development of primary gouty arthritis in a Chinese population.

    Science.gov (United States)

    Cui, Y X; Zhao, H; Guo, H Q

    2016-10-17

    In this study, we investigated the role of two single nucleotide polymorphisms in the promoter region of the interleukin-8 gene (IL-8; rs4073 and rs2227306) in the susceptibility to primary gouty arthritis in a Chinese population. Three hundred and twelve patients with primary gouty arthritis and 340 healthy controls were recruited from the Yan'an University Affiliated Hospital between January 2014 and March 2015. The IL-8 rs4073 and rs2227306 polymorphisms were genotyped by polymerase chain reaction combined with restriction fragment length polymorphism. Unconditional multiple-logistic regression analysis revealed that the TT genotype of rs4073 was correlated with primary gouty arthritis risk, compared to the AA genotype [adjusted odds ratio (OR) = 1.65, 95% confidence interval (CI) = 1.08-2.54; P = 0.02]. In addition, the IL-8 rs4073 T allele was associated with a significant elevated risk of primary gouty arthritis, in comparison to the A allele (OR = 1.34, 95%CI = 1.07-1.67; P = 0.01). However, we observed no significant relationship between the IL-8 rs2227306 polymorphism and primary gouty arthritis risk. The results of this study suggest that the IL-8 rs4073 polymorphism could be a marker for primary gouty arthritis development.

  11. No association between the SNPs (rs3749446 and rs1402000) in the PARL gene and LHON in Chinese patients with m.11778G>A.

    Science.gov (United States)

    Zhang, A-Mei; Jia, Xiaoyun; Zhang, Qingjiong; Yao, Yong-Gang

    2010-10-01

    According to a recent genome-wide linkage scan and association study of families with m.11778G>A in Thailand, two single nucleotide polymorphisms (SNPs) (rs3749446 and rs1402000) in the presenilins-associated rhomboid-like (PARL) gene were found to be associated with Leber hereditary optic neuropathy (LHON). In order to verify this association in Chinese LHON patients, we genotyped three PARL gene variants (rs3749446, rs953419, and rs1402000) in 179 patients with m.11778G>A and 170 patients with suspected LHON, and compared them to a control population containing the HapMap Chinese and 58 normal individuals analyzed in this study. We identified no association between these PARL gene SNPs and LHON in Chinese patients with m.11778G>A (P>0.05). Haplotype analysis also showed no statistical difference among the three Chinese populations.

  12. Enantioresolution of (RS)-baclofen by liquid chromatography: A review.

    Science.gov (United States)

    Batra, Sonika; Bhushan, Ravi

    2017-01-01

    Baclofen is a commonly used racemic drug and has a simple chemical structure in terms of the presence of only one stereogenic center. Since the desirable pharmacological effect is in only one enantiomer, several possibilities exist for the other enantiomer for evaluation of the disposition of the racemic mixture of the drug. This calls for the development of enantioselective analytical methodology. This review summarizes and evaluates different methods of enantioseparation of (RS)-baclofen using both direct and indirect approaches, application of certain chiral reagents and chiral stationary phases (though very expensive). Methods of separation of diastereomers of (RS)-baclofen prepared with different chiral derivatizing reagents (under microwave irradiation at ease and in less time) on reversed-phase achiral columns or via a ligand exchange approach providing high-sensitivity detection by the relatively less expensive methods of TLC and HPLC are discussed. The methods may be helpful for determination of enantiomers in biological samples and in pharmaceutical formulations for control of enantiomeric purity and can be practiced both in analytical laboratories and industry for routine analysis and R&D activities.

  13. Early determinants of attention and hyperactivity problems in adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Determinantes precoces de problemas de atenção e hiperatividade na adolescência: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Directory of Open Access Journals (Sweden)

    Luciana Anselmi

    2010-10-01

    Full Text Available The aim of this study was to assess early determinants of attention and hyperactivity problems in adolescents. In 1993, all hospital births in the city of Pelotas, Rio Grande do Sul State, Brazil, were monitored and mothers were interviewed (N = 5,249. At 11 years of age, 4,423 mothers answered the Strengths and Difficulties Questionnaire (SDQ in order to evaluate attention and hyperactivity problems in the adolescents. Crude and adjusted prevalence ratios were calculated using Poisson regression. Prevalence of attention and hyperactivity problems was 19.9%. Factors associated with the outcome in the adjusted analysis were: male gender, low family income, smoking during pregnancy, minor psychiatric disorders in the mother, and history of child's behavioral/emotional problems at four years of age. Early life events impacted attention and hyperactivity problems in adolescence. Risk factors for attention and hyperactivity problems found in this study were similar to those reported in other cultures.O objetivo deste trabalho foi estudar determinantes precoces dos problemas de atenção e hiperatividade em adolescentes. Em 1993, os nascimentos foram recrutados e as mães entrevistadas (n = 5.249. Aos 11 anos, 4.423 mães responderam ao Strengths and Difficulties Questionnaire (SDQ para avaliar problemas de atenção e hiperatividade nos adolescentes. Variáveis socioeconômicas, demográficas, biológicas e psicológicas foram investigadas como prováveis fatores de risco. Razões de prevalência brutas e ajustadas foram calculadas com regressão de Poisson. A prevalência de problemas de atenção e hiperatividade foi 19,9%. Sexo masculino, baixa renda familiar, tabagismo materno na gestação, transtornos psiquiátricos maternos e problemas de comportamento/emocionais do adolescente aos quatro anos permaneceram associados na análise ajustada. Eventos do início da vida influenciaram os problemas de atenção e hiperatividade na adolescência. Os

  14. Film coating of seeds with Bacillus cereus RS87 spores for early plant growth enhancement.

    Science.gov (United States)

    Jetiyanon, Kanchalee; Wittaya-Areekul, Sakchai; Plianbangchang, Pinyupa

    2008-10-01

    The plant growth-promoting rhizobacterium Bacillus cereus RS87 was previously reported to promote plant growth in various crops in both greenhouse and field trials. To apply as a plant growth promoting agent with practical use, it is essential to ease the burden of routine preparation of a fresh suspension of strain RS87 in laboratory. The objectives of this study were to investigate the feasibility of film-coating seeds with B. cereus RS87 spores for early plant growth enhancement and to reveal the indoleacetic acid (IAA) production released from strain RS87. The experiment consisted of the following 5 treatments: nontreated seeds, water-soaked seeds, film-coated seeds, seeds soaked with vegetative cells of strain RS87, and film-coated seeds with strain RS87 spores. Three experiments were conducted separately to assess seed emergence, root length, and plant height. Results showed that both vegetative cells and spores of strain RS87 significantly promoted (P seed emergence, root length and plant height over the control treatments. The strain RS87 also produced IAA. In conclusion, the film coating of seeds with spores of B. cereus RS87 demonstrated early plant growth enhancement as well as seeds using their vegetative cells. IAA released from strain RS87 would be one of the mechanisms for plant growth enhancement.

  15. Creative implementation of 3Rs principles within industry programs: beyond regulations and guidelines.

    Science.gov (United States)

    Bratcher, Natalie A; Reinhard, Gregory R

    2015-03-01

    The industry involved with using animals as an essential part of research has supported the theory and philosophy of the 3Rs for years. However, both the culture and approach surrounding the 3Rs is evolving rapidly, and many institutions are attempting to surpass the regulations and guidelines to implement the 3Rs for improved science and animal welfare. Regulatory documents and guidelines such as the Animal Welfare Act, the Guide for the Care and Use of Laboratory Animals, the Public Health Service Policy on Humane Care and Use of Laboratory Animals, and the US Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training clearly outline how the IACUC should address the 3Rs, but there are many additional paradigms and resources that an institution can use to promote the 3Rs creatively. We review the legal mandates and guidelines that institutions must or should follow, and we present some creative approaches toward their compliance, including the creation of full-time dedicated 3Rs roles as well as temporary 3Rs-focused positions such as visiting scientist and postdoctoral fellowships and internships. We also discuss how to creatively achieve 3Rs progress through internal committees and working groups, involvement in 3Rs consortia, recognizing 3Rs advances through awards programs, and creating 3Rs volunteer opportunities. Adherence to regulations and guidelines creates a solid foundation for good animal care and science, and creative 3Rs approaches enable the growth of a robust animal welfare culture that enhances the potential for 3Rs benefits to animals and science.

  16. Design of USB/RS232 Converter%USB与RS232接口转换器的设计

    Institute of Scientific and Technical Information of China (English)

    何源; 顾金良

    2006-01-01

    针对RS232接口向USB接口转换的需求,提出两类设计方案.一类方案以CY7C68013芯片为代表,从硬件底层固件开始,进行全面系统开发.另一类采用类似CP2102的USB/RS232双向转换专用芯片进行设计,只需对芯片功能了解和应用,无须深入开发.第一类方案由于成本和开发难度的限制而很少被采用,但在特殊的操作系统或专门的应用条件下是优选方案.第二类方案经常被采用,但因受到芯片生产商的限制而无法进行特殊的应用.应用设计人员可以根据实际情况选择适合的方案.

  17. Moscas frugívoras e seus parasitoides nos municípios de Pelotas e Capão do Leão, Rio Grande do Sul, Brasil Frugivorous flies and their parasitoids in the cities of Pelotas and Capão do Leão, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Adrise Medeiros Nunes

    2012-01-01

    Full Text Available As moscas frugívoras (Tephritoidea são as principais pragas da fruticultura de clima temperado no Brasil. O objetivo do presente trabalho foi avaliar a infestação desses dípteros e a ocorrência de seus parasitoides em frutíferas nos municípios de Pelotas e Capão do Leão, localizados na região Sul, nas safras agrícolas de 2007/08 e 2008/09. Foram coletados frutos de araçazeiro-amarelo e vermelho (Psidium cattleianum Sabine, 1821, butiazeiro [Butia capitata (Mart. Becc., 1916], caquizeiro (Diospyros kaki Linnaeus, 1753, cerejeira-do-mato (Eugenia involucrata DC., 1828, goiabeira [Psidium guajava (Linnaeus, 1753], goiabeira-serrana [Acca sellowiana (Berg. Burret, 1941], nespereira [Eriobotrya japonica (Thunb. Lindley, 1822], pessegueiro [Prunus persicae (L. Batsch, 1801], pitangueira (Eugenia uniflora Linnaeus,1753 e uvalheira (Eugenia pyriformis Cambessèdes, 1832. Os frutos foram coletados e transportados para o laboratório, onde foram individualizados e determinados os seguintes parâmetros: índice de infestação das moscas, índice de parasitismo e frequência de indivíduos por espécie de parasitoide. Foram constatadas duas espécies de Tephritidae, Anastrepha fraterculus (Wiedemann, 1830 (90,5% e Ceratitis capitata (Wiedemann, 1824 (9,5% e duas de Lonchaeidae, Neosilba zadolicha McAlpine & Steyskal, 1982 (87,8% e uma espécie ainda não descrita, referida como Neosilba n. sp. 3 (12,2%. Anastrepha fraterculus é a espécie mais abundante nos dois municípios, sendo constatada na maioria das frutíferas coletadas. Caquizeiro e goiabeira foram os hospedeiros que apresentaram o maior índice de infestação por C. capitata. Quanto às espécies de Neosilba, a maior infestação ocorreu em frutos de goiabeira-serrana. Dos parasitoides emergidos, foram identificadas três espécies, sendo duas de Braconidae, Doryctobracon areolatus (Szépligeti, 1911 (52,6% e Opius bellus (Gahan, 1930 (27,5% e uma espécie de Figitidae, Aganaspis

  18. Pædagoguddannelsen på tværs

    DEFF Research Database (Denmark)

    Siersted, Mette

    2008-01-01

    problemer. Johny Lauritsen: Professioner på tværs. Jens Willer: Pædagogisk udviklingsarbejde og dokumentation. Bachelorprojektet - praksis i uddannelsen til professionsbachelor / af Maria Wahlgreen og Bodil Høyer). Pædagogik (Bjørn Hamre: Introduktion). De faglige discipliners blikke på pædagogik (Bjørn......-Sørensen: Special- og socialpædagogik i et inkluderende perspektiv. Ida Kornerup: Pædagogiske læreplaner og læring. Jens Willer: Empowerment i et sundhedspædagogisk perspektiv. Vibe Larsen: Interkulturel pædagogik. Johnny Lauritsen: Eksistens og pædagogik). Dansk, kultur og kommunikation (Introduktion / af Maria...

  19. Sustentabilidade empresarial no contexto das vinte maiores empresas do RS

    Directory of Open Access Journals (Sweden)

    Mariluci Nuglisch Lima

    2013-11-01

    Full Text Available O presente trabalho teve como objetivo verificar se há divulgação de ações e iniciativas ambientais adotadas pelas vinte maiores empresas no RS. A coleta dos dados foi por meio dos sites e relatórios e, em seguida, sua interpretação, utilizando a análise descritiva de dados. Por fim, evidencia-se a falta do disclosure em valores monetários relacionados nas demonstrações financeiras, o que muito pouco se visualizou nos demonstrativos publicados, bem como uma maior divulgação destas em suas páginas online.

  20. NETWORK INTRUSION DETECTION METHOD BASED ON RS-MSVM

    Institute of Scientific and Technical Information of China (English)

    Xiao Yun; Han Chongzhao; Zheng Qinghua; Zhang Junjie

    2006-01-01

    A new method called RS-MSVM (Rough Set and Multi-class Support Vector Machine) is proposed for network intrusion detection. This method is based on rough set followed by MSVM for attribute reduction and classification respectively. The number of attributes of the network data used in this paper is reduced from 41 to 30 using rough set theory. The kernel function of HVDM-RBF (Heterogeneous Value Difference Metric Radial Basis Function), based on the heterogeneous value difference metric of heterogeneous datasets, is constructed for the heterogeneous network data. HVDM-RBF and one-against-one method are applied to build MSVM. DARPA (Defense Advanced Research Projects Agency) intrusion detection evaluating data were used in the experiment. The testing results show that our method outperforms other methods mentioned in this paper on six aspects: detection accuracy, number of support vectors, false positive rate, false negative rate, training time and testing time.

  1. 0-3 års pædagogik

    DEFF Research Database (Denmark)

    Broström professor m.so., Stig

    2013-01-01

    Institutioner og pasningstilbud til de 0-3 årige har eksisteret gennem en lang årrække. Danmark en relativ høj dækningsgrad sammenlignet med andre lande. Tilbuddene er primært vuggestuer, integrerede institutioner og dagpleje. Der er de senere år kommet mere politisk og forskningsmæssigt fokus på...... områdets betydning i takt med, at forskningen har understreget den enorme betydning 0-3 års alderen har for børn og unges senere succes i livet. Men hvad pædagogikken rent faktisk består af i disse institutionelle rammer er desværre forskningsmæssigt underbelyst. I denne kvalitative analyse beskrives kort...

  2. Family-Based Association Study of rs17300539 and rs12495941 Polymorphism in Adiponectin Gene and Polycystic Ovary Syndrome in a Chinese Population

    Science.gov (United States)

    Sun, Xianchang; Wu, Xingguo; Duan, Yunmin; Liu, Guanghai; Yu, Xinyan; Zhang, Wenjuan

    2017-01-01

    Backgriond Polycystic ovary syndrome (PCOS) is a complex disease that has both genetic and environmental components. Adiponectin plays an important role in the regulation of insulin sensitivity and insulin resistance (IR) in PCOS. The aim of this study was to determine 2 single-nucleotide polymorphisms (SNPs) variants (rs12495941 and rs17300539) of the adiponectin gene (ADIPOQ) in polycystic ovary syndrome (PCOS) families. Material/Methods We recruited 197 PCOS probands, their biological parents, and 192 controls. Anthropometric variables, including hip circumference (HC) and waist circumference (WC), were measured in all subjects during their first visit to the outpatient department. Serum T, FBG, FINS, TC, TG, LDL, and HDL levels were measured. PCOS patients were divided into 2 groups based on BMI: group A (BMI <25 kg/m2) and group B (BMI ≥25 kg/m2). Parents of PCOS were accordingly categorized into group C and group D (fathers), and group E and group F (mothers). The associations among ADIPOQ rs12495941, rs17300539, and PCOS were analyzed using the transmission disequilibrium test (TDT). Results A significant association was found between SNP rs17300539 and PCOS in our Chinese population. The levels of TG and FINS and the genotype frequencies of rs17300539 are significantly different between overweight and lean PCOS. No significant association was detected for rs12495941. Conclusions TDT confirms that rs17300539 of ADIPOQ is strongly associated with the risk of PCOS in a Chinese Han population, but rs12495941 of ADIPOQ is not associated with the occurrence of PCOS. PMID:28060790

  3. Functional analysis of deep intronic SNP rs13438494 in intron 24 of PCLO gene.

    Directory of Open Access Journals (Sweden)

    Seunghee Seo

    Full Text Available The single nucleotide polymorphism (SNP rs13438494 in intron 24 of PCLO was significantly associated with bipolar disorder in a meta-analysis of genome-wide association studies. In this study, we performed functional minigene analysis and bioinformatics prediction of splicing regulatory sequences to characterize the deep intronic SNP rs13438494. We constructed minigenes with A and C alleles containing exon 24, intron 24, and exon 25 of PCLO to assess the genetic effect of rs13438494 on splicing. We found that the C allele of rs13438494 reduces the splicing efficiency of the PCLO minigene. In addition, prediction analysis of enhancer/silencer motifs using the Human Splice Finder web tool indicated that rs13438494 induces the abrogation or creation of such binding sites. Our results indicate that rs13438494 alters splicing efficiency by creating or disrupting a splicing motif, which functions by binding of splicing regulatory proteins, and may ultimately result in bipolar disorder in affected people.

  4. Association of the Three Common SNPs of Cyclooxygenase-2 Gene (rs20417, rs689466, and rs5275 with the Susceptibility of Breast Cancer: An Updated Meta-Analysis Involving 34,590 Subjects

    Directory of Open Access Journals (Sweden)

    Zhi-Jun Dai

    2014-01-01

    Full Text Available Several single nucleotide polymorphisms have been identified in cyclooxygenase-2 (COX-2 genes (e.g., −765 G>C (rs20417, −1195G>A (rs689466, and 8473 C>T (rs5275. The association of these SNPs with the risk of different cancer types is still controversial. This study aims to evaluate the correlation between these SNPs and breast cancer risk in different ethnic groups. We have searched PubMed, Web of Knowledge, and Embase for relevant studies. Odds ratios (ORs with 95% confidence intervals (CIs were used to estimate the strength of the associations. A total of 13 studies (15,330 cases and 19,260 controls were eligible for meta-analysis. This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians. The rs5275 polymorphism had no association with breast cancer risk.

  5. Design and Implementation of RS232/PROFIBUS-DP Intelligent Slave%PROFIBUS-DP/RS232智能从站的设计与实现

    Institute of Scientific and Technical Information of China (English)

    王征; 张婕; 张云生

    2007-01-01

    实现RS232设备和PROFIBUS-DP总线的通讯对于工业控制有着重要的意义.本文介绍了PROFIBUS-DP/RS232智能从站的设计要点,阐述了智能从站在硬件和软件上的实现方法.实践表明:智能从站对主站和RS232接口设备具有数据传输功能,为系统开放互连和现场分布式控制打下基础.

  6. Design of RS232 Serial Communication Based on C%基于C语言的RS232串口通信的设计

    Institute of Scientific and Technical Information of China (English)

    张志阳; 吴秀丽

    2014-01-01

    Serial communication is a communication mode between peripheral equipments and computer by sending a bit at one time. This paper briefly introduces RS-232 serial communication, and realizes the communica-tion through the C programming language.%串口通信是指外设和计算机间,通过相应的数据线,按位进行传输数据的一种通讯方式。本文将简要介绍RS-232串口通信,并通过C语言程序实现RS232串行通信。

  7. Design of USB -RS232 Converter and extend adapter%USB-RS232串口转换与扩展卡的设计

    Institute of Scientific and Technical Information of China (English)

    李祖裕; 古天祥; 周继勇

    2004-01-01

    本文提出了一种USB接口到RS232接口的串口转换及多串口扩展卡的设计方案,给出了该方案的硬件组成原理及软件设计方法.文中详细讨论了USB到RS232的转换技术,以及RS232多串口扩展技术的硬件和软件的设计.

  8. Relationship of TFAM gene′s two polymorphic loci rs10826178 and rs4390300 with schizophrenia%TFAM 基因 rs10826178与 rs4390300两多态位点与精神分裂症的关系

    Institute of Scientific and Technical Information of China (English)

    孙逸杰; 景戈翰; 杨菁; 何书平; 仝冬晓; 王丽雯; 司沛茹; 金璐; 程晓丽

    2015-01-01

    Aim:To research the relationship between mitochondrial transcription factor A ( TFAM) gene′s two poly-morphic loci and schizophrenia .Methods: The PCR-RFLP analysis and DNA sequencing technology were used to detect polymorphism of rs10826178 and rs4390300 in 237 cases of schizophrenia(patient group) and 246 healthy subjects(control group) .Results:The genotype frequencies and allele frequencies of TFAM gene rs 10826178 and rs4390300 in the two groups had no differences(P>0.05).Conclusion:TFAM gene rs10826178 and rs4390300 polymorphisms may not be as-sociated with schizophrenia .%目的:探讨线粒体转录因子A( TFAM)基因多态性与精神分裂症的关系。方法:采用PCR-RFLP及DNA序列分析技术分别对237例精神分裂症患者及246例健康对照TFAM基因rs10826178、rs4390300两多态位点进行检测及分析。结果:rs10826178与rs4390300位点等位基因与基因型频率分布在两组之间比较,差异无统计学意义(P均>0.05)。结论:TFAM基因rs4390300、rs10826178的基因型差异可能与精神分裂症的发病无关。

  9. Genetic Polymorphism of E-selectin Gene rs5359A/G and rs4786G/A in Chinese Guangxi Populations%中国广西地区健康人群E-选择素基因rs5359A/G、rs4786G/A 多态性分析

    Institute of Scientific and Technical Information of China (English)

    王春芳; 韦叶生; 王俊利; 潘国刚; 韦贵将; 罗春英; 黄照权

    2013-01-01

    Objective: To study the frequencies of allele and genotype distribution of E-selectin gene rs5359A/G and rs4786G,/A single nucleotide polymorphism (SNP) in Chinese guangxi populations, and to analyze the distributions of E-selectin polymorphisms among different races. Method: The E-selectin gene polymorphisms were examined by the polymerase chain reaction-single base extension (PCR-SBE) technique and DNA sequencing methods in 199 Chinese guangxi populations, frequencies of allele and genotype of E-selectin gene rs5359A/G, rs4786G/A polymorphisms were analyzed for guangxi populations, and compared with Hap-Map-CEU, HapMap-YRI, HapMap-JPT and HapMap-HCB, which come from human genome project group (Hapmap) datas. Results: There were E-selectin gene rs5359A/G and rs4786G/A polymorphisms in guangxi populations. The frequencies of allele and genotype of E-selectin gene rs5359A/G and rs4786G/A polymorphisms were not different between male and female in guangxi group and HapMap-YRI, HapMap-JPT and HapMap-HCB (P>0. 05). But the frequencies of allele and genotype distribution of E-selectin gene rs5359A/G and rs4786G/A polymorphisms were significant different compared with HapMap-CEU populations (P0.05),但与欧洲人群比较差异有统计学意义(P<0.05).结论:中国广西地区健康人群E-选择素基因rs5359A/G、rs4786G/A 存在多态性,与欧洲人群比较存在显著性差异,这种差异对于人类学研究可能起到重要作用.

  10. rs3806268 of NLRP3 gene polymorphism is associated with the development of primary gout

    Science.gov (United States)

    Deng, Jianping; Lin, Wen; Chen, Yunpeng; Wang, Xin; Yin, Zhong; Yao, Chunhong; Liu, Tangbing; Lv, Yonghong

    2015-01-01

    The aim of the present study was to investigate the association between seven functional SNPs in NALP3 gene and the susceptibility to primary gout. A total of 247 patients with primary gout and 247 controls were selected in this study. Genotyping of NALP3 rs4612666, rs3806268, rs12239046, rs10754558, rs7512998, rs12137901 and rs12565738 was performed using the Sequenom MassARRAY platform. Comparison analysis showed that primary gout patients were more likely to have a higher body mass index, DBP, SBP, TG, urea nitrogen and uric acid (P < 0.05). According to logistic regression analysis, individuals carrying with the GG genotype of rs3806268 were associated with increased risk of primary gout when compared with the AA genotype (OR=1.83, 95% CI=1.03-3.26). However, no significant associations were identified for the remaining SNPs. In conclusion, we found a significant association between rs3806268 in NLRP3 gene and the risk of primary gout in a Chinese population. Further clinical and genetic studies are required to investigate the mechanisms underlying the association between NALP3 polymorphisms and the development of primary gout. PMID:26722603

  11. Replicating function of the RS1 element associated with Vibrio cholerae CTX phi prophage.

    Science.gov (United States)

    Campos, J; Fando, R; Silva, A; Rodriguez, B L; Benitez, J A

    1998-07-01

    The RS1 element associated with Vibrio cholerae CTX phi prophage was cloned from an E1 Tor biotype Vibrio cholerae strain. We used the recA- vaccine strain Peru-15, that lacks the target for RS-mediated site-specific integration, to show that RS1 promotes autonomous replication of a suicide vector. A linker insertion in the rstR open reading frame abolished autonomous replication in Peru-15 but not in a strain containing an RS1 in the chromosome. An AT-rich region containing cis-acting elements involved in autonomous replication was identified by deletion. This region was sufficient to support autonomous replication in a strain containing an RS1 in the chromosome. DNA sequence analysis of a region present in RS1 and not RS2 revealed the presence of putative binding sites for host proteins involved in plasmid replication. These results indicate that RS1 contains a replicon distinct from RS2 which could be involved in replicative recombination events associated with tandem amplification of the CTX element.

  12. 基于RS232-CAN和RS232-USB协议模块的设计

    Institute of Scientific and Technical Information of China (English)

    郭耀泉; 吴淑娟; 陈永汉

    2012-01-01

    本文针对计算机与多个控制器构成的控制系统,提出了一种基于USB-RS232和CAN-R S232协议转换模块的多主通讯模式,与传统的基于R S232和R S485的主从通讯方式相比,不仅提高了通讯速度与效率,而且还提高了通讯的可靠性和稳定性.然后,从软硬件两个方面对所设计的USB-R S232和CAN-R S232协议转换模块进行详细的介绍.

  13. The Two-Component System CprRS Senses Cationic Peptides and Triggers Adaptive Resistance in Pseudomonas aeruginosa Independently of ParRS

    DEFF Research Database (Denmark)

    Fernandez, Luca; Jenssen, Håvard; Bains, Manjeet

    2012-01-01

    dependency on the CprRS and ParRS systems in a concentration-dependent manner. It was further demonstrated that, following exposure to inducing antimicrobial peptides, cprRS mutants did not become adaptively resistant to polymyxins as was observed for wild-type cells. Our microarray studies demonstrated...... that the CprRS system controlled a quite modest regulon, indicating that it was quite specific to adaptive peptide resistance. These findings provide greater insight into the complex regulation of LPS modification in Pseudomonas aeruginosa, which involves the participation of at least 4 two-component systems.......Cationic antimicrobial peptides pass across the outer membrane by interacting with negatively charged lipopolysaccharide (LPS), leading to outer membrane permeabilization in a process termed self-promoted uptake. Resistance can be mediated by the addition of positively charged arabinosamine through...

  14. A Combination of CD28 (rs1980422 and IRF5 (rs10488631 Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study.

    Directory of Open Access Journals (Sweden)

    Lucia Vernerova

    Full Text Available The aim of the study was to analyse genetic architecture of RA by utilizing multiparametric statistical methods such as linear discriminant analysis (LDA and redundancy analysis (RDA.A total of 1393 volunteers, 499 patients with RA and 894 healthy controls were included in the study. The presence of shared epitope (SE in HLA-DRB1 and 11 SNPs (PTPN22 C/T (rs2476601, STAT4 G/T (rs7574865, CTLA4 A/G (rs3087243, TRAF1/C5 A/G (rs3761847, IRF5 T/C (rs10488631, TNFAIP3 C/T (rs5029937, AFF3 A/T (rs11676922, PADI4 C/T (rs2240340, CD28 T/C (rs1980422, CSK G/A (rs34933034 and FCGR3A A/C (rs396991, rheumatoid factor (RF, anti-citrullinated protein antibodies (ACPA and clinical status was analysed using the LDA and RDA.HLA-DRB1, PTPN22, STAT4, IRF5 and PADI4 significantly discriminated between RA patients and healthy controls in LDA. The correlation between RA diagnosis and the explanatory variables in the model was 0.328 (Trace = 0.107; F = 13.715; P = 0.0002. The risk variants of IRF5 and CD28 genes were found to be common determinants for seropositivity in RDA, while positivity of RF alone was associated with the CTLA4 risk variant in heterozygous form. The correlation between serologic status and genetic determinants on the 1st ordinal axis was 0.468, and 0.145 on the 2nd one (Trace = 0.179; F = 6.135; P = 0.001. The risk alleles in AFF3 gene together with the presence of ACPA were associated with higher clinical severity of RA.The association among multiple risk variants related to T cell receptor signalling with seropositivity may play an important role in distinct clinical phenotypes of RA. Our study demonstrates that multiparametric analyses represent a powerful tool for investigation of mutual relationships of potential risk factors in complex diseases such as RA.

  15. RS232/CAN智能协议转换器及其通信网络%RS232/CAN Intelligent Protocol Converter and Its Communication Network

    Institute of Scientific and Technical Information of China (English)

    赵志军; 王建英

    2007-01-01

    为研制RS232/CAN智能协议转换器,根据技术要求,确定其硬件系统主要由RS232接口、CAN协议控制器和CAN总线收发器等组成,软件系统主要由参数设置子程序、RS232串口/CAN转换子程序、CRC校验子程序等组成.关键技术包括:在CAN控制器软件初始化过程中对系统中断的控制;采用硬件流控制实现数据传输过程的控制.将2个RS232/CAN智能转换器通过双绞线连接起来,实现2个设备之间的RS232点对点远程通信.在各设备处安装RS232/CAN智能转换器,通过双绞线连接,并在端点处安装匹配电阻即可组成RS232/CAN通信网络.在调度集中车站智能自律分机系统中,采用RS232/CAN智能协议转换器构建通信网络,既可充分利用原来的软硬件系统,又可提高系统的效率,缩短开发周期.

  16. Lack of association of two common polymorphisms rs2910164 and rs11614913 with susceptibility to hepatocellular carcinoma: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Zhongxia Wang

    Full Text Available BACKGROUND: Single nucleotide polymorphisms (SNPs in microRNA-coding genes may participate in the process of carcinogenesis by altering the expression of tumor-related microRNAs. It has been suggested that two common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to hepatocellular carcinoma (HCC. However, published results are inconsistent and inconclusive. In the present study, we performed a meta-analysis to systematically summarize the possible association between the two SNPs and the risk for HCC. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a search of case-control studies on the associations of SNPs rs2910164 and/or rs11614913 with susceptibility to HCC in PubMed, EMBASE, ISI Web of Science, Cochrane Central Register of Controlled Trials, ScienceDirect, Wiley Online Library and Chinese National Knowledge Infrastructure databases. Data from eligible studies were extracted for meta-analysis. HCC risk associated with the two polymorphisms was estimated by pooled odds ratios (ORs and 95% confidence intervals (95% CIs. 5 studies on rs2910164 and 4 studies on rs11614913 were included in our meta-analysis. Our results showed that neither allele frequency nor genotype distribution of the two polymorphisms was associated with risk for HCC in all genetic models. Similarly, subgroup analysis in Chinese population showed no association between the two SNPs and the susceptibility to HCC. CONCLUSIONS/SIGNIFICANCE: This meta-analysis suggests that two common SNPs rs2910164 and rs11614913 are not associated with the risk of HCC. Well-designed studies with larger sample size and more ethnic groups are required to further validate the results.

  17. The rs4646 and rs12592697 Polymorphisms in CYP19A1 Are Associated with Disease Progression among Patients with Breast Cancer from Different Racial/Ethnic Backgrounds

    Science.gov (United States)

    Armamento-Villareal, Reina; Shah, Vallabh O.; Aguirre, Lina E.; Meisner, Angela L. W.; Qualls, Clifford; Royce, Melanie E.

    2016-01-01

    Given the racial/ethnic disparities in breast cancer, we evaluated the association between CYP19A1 single nucleotide polymorphisms (SNPs) on disease progression in women with breast cancer from different racial/ethnic backgrounds. This is a cross-sectional analysis of data from 327 women with breast cancer in the Expanded Breast Cancer Registry program of the University of New Mexico. Stored DNA samples were analyzed for CYP19A1 SNPs using a custom designed microarray panel. Genotype-phenotype correlations were analyzed. Of the 384 SNPs, 2 were associated with clinically significant outcomes, the rs4646 and rs12592697. The T allele for the rs4646 was associated with advanced stage of the disease at the time of presentation (odds ratio [OR]:1.8, confidence intervals [CI]: 1.05–3.13, p < 0.05) and a more progressive disease (OR: 2.1 [CI: 1.1–4.0], p = 0.04). For the rs12592697, the variant T allele was more frequent in Hispanic women and associated with a more progressive disease (OR: 2.05 [CI: 1.0–4.0], p = 0.04). However, further analysis according to menopausal status showed that the association between these 2 SNPs with disease progression or the stage at diagnosis are confined only to postmenopausal women. The odds ratios of disease progression among postmenopausal women carrying the T allele for the rs4646 and rs12592697 are 3.05 (1.21, 7.74, p = 0.02) and 3.80 (1.24, 11.6, p = 0.02), respectively. Regardless, differences in disease progression among the different genotypes for both SNPs disappeared after adjustment for treatment. In summary, the rs4646 and the rs12592697 SNPs in CYP19A1 are associated with differences in disease progression in postmenopausal women. However, treatment appears to mitigate the differences in genetic risk. PMID:27994616

  18. Muscle-Related Polymorphisms (MSTN rs1805086 and ACTN3 rs1815739) Are Not Associated with Exceptional Longevity in Japanese Centenarians

    Science.gov (United States)

    Yvert, Thomas; Zempo, Hirofumi; Naito, Hisashi; Abe, Yukiko; Arai, Yasumichi; Murakami, Haruka; Miyachi, Motohiko; Pareja-Galeano, Helios; Emanuele, Enzo; Hirose, Nobuyoshi; Lucia, Alejandro

    2016-01-01

    Myostatin (MSTN) and α-actinin-3 (ACTN3) genes are potentially associated with preservation of muscle mass and oxidative capacity, respectively. To explore the possible role of these genes in exceptional longevity (EL), the allele/genotype frequency distribution of two polymorphisms in MSTN (rs1805086, K153R) and ACTN3 (rs1815739, R577X) was studied in Japanese centenarians of both sexes (n = 742) and healthy controls (n = 814). The rs1805086 R-allele (theoretically associated with muscle mass preservation at the expense of oxidative capacity) was virtually absent in the two groups, where genotype distributions were virtually identical. Likewise, no differences in allele (p = 0.838 (women); p = 0.193 (men); p = 0.587 (both sexes)) or genotype distribution were found between groups for ACTN3 rs1815739 (p = 0.975 (women), p = 0.136 (men), p = 0.752 (both sexes)). Of note, however, the frequency of the rs1805086 R-allele observed here is the lowest been reported to date whereas that of the ‘highly oxidative/efficient’ rs1815739 XX genotype in Japanese male centenarians (33.3%) or supercentenarians of both sexes (≥110 years) are the highest (32.6%), for a non-American population. No definite conclusions can be inferred in relation to EL owing to its lack of association with both rs1815739 and rs1805086. However, it cannot be excluded that these gene variants could eventually be related to a “healthy” metabolic phenotype in the Japanese population. Further research might determine if such metabolic profile is among the factors that can potentially predispose these individuals to live longer than Caucasians and what genetic variants might be actually involved. PMID:27861536

  19. Association between rs7517847 and rs2201841 polymorphisms in IL-23 receptor gene and risk of ankylosing spondylitis: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Bin Xu

    2015-04-01

    Full Text Available To comprehensively evaluate the association between rs7517847 and rs2201841 polymorphisms in the Interleukin-23 (IL-23 receptor gene and ankylosing spondylitis (AS, a meta-analysis was performed. The Pubmed, Embase, MEDLINE, Cochrane, China National Knowledge Infrastructure (CNKI, VIP, Wanfang and China Biology Medicine disc (CBMdisc databases were searched to identify eligible studies on rs7517847 and rs2201841 polymorphisms in the IL-23 receptor gene and AS that were published through September 2014. Data of interest were extracted from each study, and the meta-analysis was performed using STATA 12.0. Four studies were eligible for the meta-analysis and included a total patient population of 2,465. With regards to rs7517847, the current study showed that the genotype GG and allele G might play a protective role during AS (OR = 0.76, 95% CI [0.59–0.99]; OR = 0.88, 95% CI [0.78–0.99] for homozygote and allelic models, respectively. However, according to the meta-analysis, there was no statistical association between the genotype or allele of rs2201841 and an individual’s susceptibility to AS in all genetic models. In conclusion, it was the IL-23 rs7517847 polymorphism rather than the rs2201841 polymorphism that had a statistical association with AS. Nevertheless, more evidence is needed to confirm this result. Consequently, it is necessary to carry out more high-quality studies to confirm the associations between these two single nucleotide polymorphisms and AS.

  20. Association of the ACE rs4646994 and rs4341 polymorphisms with the progression of carotid atherosclerosis in slovenian patients with type 2 diabetes mellitus

    Science.gov (United States)

    Merlo, S; Novák, J; Tkáčová, N; Nikolajević Starčević, J; Šantl Letonja, M; Makuc, J; Cokan Vujkovac, A; Letonja, J; Bregar, D; Zorc, M; Rojko, M; Mankoč, S; Kruzliak, P

    2015-01-01

    Abstract The current study was designed to reveal possible associations between the angiotensin-converting-enzyme (ACE) gene polymorphisms (rs4646994 and rs4341) with markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM) in a 4-year-long follow-up study. Five hundred and ninety-five T2DM subjects and 200 control subjects were enrolled. Genotyping of ACE polymorphisms was performed using KASPar assays, and ultrasound examinations were performed twice (at the enrollment and at follow-up). With regard to the progression of atherosclerosis in subjects with T2DM, statistically significant differences were demonstrated in the change of the sum of carotid plaques thickness for the rs4646994 polymorphism. We did not demonstrate an association between the tested polymorphisms (rs4646994 and rs4341) and either carotid intima media thickness (CIMT) or CIMT progression in a 3.8-year period. In our study, we demonstrated that subjects with T2DM with the DD genotype of the rs4646994 [ACE insertion/deletion (I/D)] polymorphism had faster progression of atherosclerosis in comparison to subjects with other genotypes. PMID:27785395

  1. DSP network control system based on RS485%基于RS485总线的DSP网络控制系统设计

    Institute of Scientific and Technical Information of China (English)

    沈文杰; 陈文清; 陈伟

    2011-01-01

    To make reliable communication between multiple industrial production data in a computer control system, and to achieve real time control, the RS485 network control system is proposed in this paper based on TMS320LF2407A. The design of DSP network control system is introduced. The hardware of field control note was designed using RS485 bus, and the detailed software implementation is described. The RS485 reliable dato communications is achieved between the PC and the bottom of the controller's. It verified their network control targets through the production site.%为了使工业生产计算机控制系统中多种数据之间有可靠通讯,满足过程实时控制的要求,提出了一种基于DSP的网络控制系统的设计方案,介绍了DSP网络控制系统的总体设计思路,运用RS485总线技术对现场控制节点进行硬件设计并对RS485通讯软件的实现进行了详细地分析,实现了上位机与底层控制器之间的RS485数据的可靠通讯,通过生产现场调试验证了网络控制指标.

  2. Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome.

    Science.gov (United States)

    Li, Chao; Shi, Yuhua; You, Li; Wang, Laicheng; Chen, Zi-Jiang

    2011-03-01

    The aim of the present study was to determine whether or not the 'melatonin receptor (MTNR1B)' gene polymorphisms are associated with a predisposition for polycystic ovary syndrome (PCOS). The single-nucleotide polymorphisms (SNPs), rs10830963 and rs10830962, in the MTNR1B gene were detected in 526 patients with PCOS and 547 healthy Chinese Han women. The association between MTNR1B gene variants and plasma glucose and insulin levels during the oral glucose tolerance test (OGTT) and hormone levels was investigated. The frequencies of three genotypes and two allelotypes of the SNP, rs10830963, differed significantly between women with PCOS and healthy controls (P insulin resistance (HOMA-IR; P = 0.027). No significant differences were observed in the genotypes and allele distributions of rs10830962 polymorphisms between the PCOS and the control groups (P = 0.311 and P = 0.178, respectively). There was no significant difference in the clinical and the metabolic characteristics in women with PCOS with different genotypes in the SNP, rs10830962 (all P > 0.005). The present study suggest that the SNP, rs10830963, in the MTNR1B gene is not only associated with susceptibility to PCOS, but also contributes to the PCOS phenotype.

  3. Study of association between polymorphisms in the PSMB5 (rs11543947 and PSMA3 (rs2348071 genes and multiple sclerosis in Latvians

    Directory of Open Access Journals (Sweden)

    Kalnina J.

    2014-07-01

    Full Text Available Functional realization of many signalling proteins and transcription factors implicated in the development and progression of multiple sclerosis is mediated by proteasomes. Aim of this case-control study was to evaluate genetic variations in the PSMB5 and PSMA3 genes encoding proteasomal subunits on the susceptibility to multiple sclerosis in Latvians. Methods. The rs11543947 (PSMB5 and rs2348071 (PSMA3 loci were genotyped in 291 multiple sclerosis patients and 305 healthy individuals and analysed general, subtype and sex-specific associations with the disease. Results. Loci rs11543947 and rs2348071 were identified as disease neutral and susceptible respectively. The rs2348071 heterozygous genotype GA showed strong main effect (P < 0.001; OR = 1.891, 95 % CI [1.360–2.628], and moderate (P < 0.01; OR = 1.663, 95 % CI [1.152– 2.402] and strong (P < 0.001; OR = 2.459, 95 % CI [1.534–3.943] association with relapsing-remitting and secondary progressive phases of disease respectively. No genotype-sex interaction associated with multiple sclerosis has been detected. Conclusions. Our results suggest susceptibility of the rs2348071 heterozygous genotype to multiple sclerosis in Latvians.

  4. Association of the IGF-1 rs35767 and rs972936 polymorphisms with the risk of osteoporosis in a Chinese postmenopausal female population.

    Science.gov (United States)

    Wei, Y K; Ma, H L; Guo, Y Z; Yang, B H; Pang, W X

    2015-11-13

    The aim of our study was to conduct a case-control study in a Chinese postmenopausal population to evaluate the roles of the IGF-1 rs35767 and rs972936 polymorphisms on bone mineral density (BMD) levels and osteoporosis risk. A total of 272 consecutive postmenopausal women with a primary diagnosis of osteoporosis and 272 controls were enrolled in the study between 2012 and 2014. The polymerase chain reaction-restriction fragment length polymorphism method was used to genotype the rs35767 and rs972936 IGF-1 polymorphisms. By comparing the demographic characteristics between patients and controls, patients with osteoporosis were found to be more likely to have a habit of alcohol drinking (P = 0.023). Furthermore, the BMD levels of the L1-L4 vertebrae, femoral necks, total hips, and trochanters in patients with osteoporosis were significantly lower than those in controls. By conditional regression analysis, we found that the IGF-1 rs2288377 and rs972936 gene polymorphisms were not associated with the risk of osteoporosis (P osteoporosis.

  5. Intake of fat and fiber-rich foods according to socioeconomic status: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Consumo de alimentos com alto teor de gordura e fibras entre adolescentes, segundo posição socioeconômica: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Directory of Open Access Journals (Sweden)

    Marilda B. Neutzling

    2010-10-01

    Full Text Available This study describes the food intake of adolescents participating in the 1993 birth cohort from Pelotas, Southern Brazil, according to socioeconomic position. We carried out a cross-sectional analysis of data collected in the 2004-2005 follow-up visit. Food intake in the previous year was evaluated using the Block questionnaire. Socioeconomic status was evaluated based on an assets index, divided into quintiles. Foods with the highest frequency of daily intake were white bread (83%, butter or margarine (74.6%, beans (66.4% and milk (48.5%. Intake of butter or margarine, bread, and beans was more frequent among poorer adolescents, and the inverse was true for milk. Intake of fruits and vegetables was low in all socioeconomic strata, but particularly low among the poor. In early adolescence, all socioeconomic groups showed high consumption of foods rich in fat and low consumption of foods rich in fiber.O estudo descreve alimentos consumidos por adolescentes pertencentes à coorte de nascimentos de 1993 de Pelotas, Rio Grande do Sul, Brasil, conforme o nível socioeconômico. Foi feita uma análise transversal com dados coletados no acompanhamento de 2004-2005. A freqüência alimentar no último ano foi avaliada pelo questionário Block. A posição socioeconômica foi verificada com base no índice de bens, dividido em quintis. Os alimentos mais consumidos diariamente foram: pão branco (83%, manteiga ou margarina (74,6%, feijão (66,4% e leite (48,5%. O consumo de manteiga ou margarina, pão e feijão foram mais freqüentes entre adolescentes pertencentes ao primeiro (menor quintil do índice de bens, e o consumo de leite foi maior no último quintil. Frutas, vegetais e salada verde tiveram baixo consumo principalmente entre os mais pobres. Todos os grupos socioeconômicos apresentaram consumo elevado de alimentos ricos em gordura e baixo consumo de alimentos ricos em fibra.

  6. Prevenção de defeitos do tubo neural: prevalência do uso da suplementação de ácido fólico e fatores associados em gestantes na cidade de Pelotas, Rio Grande do Sul, Brasil Prevention of neural tube defects: prevalence of folic acid supplementation during pregnancy and associated factors in Pelotas, Rio Grande do Sul State, Brazil

    Directory of Open Access Journals (Sweden)

    Cíntia Leal Sclowitz Mezzomo

    2007-11-01

    Full Text Available Com o objetivo de determinar a prevalência do uso do ácido fólico e fatores associados na gestação e no período periconcepcional, realizou-se um estudo transversal de base populacional nas cinco maternidades da cidade de Pelotas, Rio Grande do Sul, Brasil. A coleta de dados ocorreu no período de 1º de abril a 15 de agosto de 2006, com 1.450 mulheres. As entrevistas foram realizadas em nível hospitalar por questionário padronizado. A análise estatística se realizou por regressão de Poisson. A prevalência do uso de ácido fólico na gestação foi de 31,8%, e no período periconcepcional, foi de 4,3%. Os fatores associados ao uso de ácido fólico foram: cor branca, escolaridade acima de nove anos, renda acima de 600 Reais, idade acima de trinta anos, gestação planejada, sete ou mais consultas de pré-natal, consultas na rede privada de saúde e conhecimento sobre o ácido fólico. Para diminuir a prevalência de defeitos do tubo neural, é importante promover-se o uso do ácido fólico nas mulheres em idade fértil, nas mulheres sócio-economicamente menos favorecidas e torná-lo disponível na rede pública de saúde.To determine folic acid use and associated factors, a cross-sectional population-based study was conducted in all five maternity hospitals in Pelotas, Rio Grande do Sul State, Brazil. Data were collected from April 1 to August 15, 2006 (n = 1,450 women. A standard questionnaire was applied in the hospitals. Statistical analysis used Poisson regression. Prevalence of folic acid consumption during pregnancy was 31.8%, and periconceptional use was 4.3%. The following were associated with folic acid use: white skin color, schooling > 9 years, family income > R$600, age > 30 years, planned pregnancy, > 7 prenatal visits, knowledge on folic acid, and prenatal care in the private health system. In order to prevent neural tube defects, it is important to promote folic acid use among childbearing-age women and to supply folic

  7. O impacto do baixo peso ao nascer relacionado à depressão gestacional para o financiamento federal da saúde pública: uma análise do Município de Pelotas, Rio Grande do Sul, Brasil The impact of low birth weight related to gestational depression on Federal funding of public health: a study in Pelotas, Rio Grande do Sul State, Brazil

    Directory of Open Access Journals (Sweden)

    Leticia Oliveira de Menezes

    2012-10-01

    Full Text Available O baixo peso ao nascer está relacionado com morbimortalidade e sequelas no desenvolvimento infantil, impactando nos custos dos sistemas de saúde, por isso é importante avaliar fatores que o influenciam, estimando seu impacto no Sistema Único de Saúde (SUS. Este é um estudo prospectivo aninhado a uma coorte de gestantes que realizaram pré-natal e parto exclusivamente pelo SUS nos hospitais com UTI da cidade de Pelotas, Rio Grande do Sul, Brasil. Entre os resultados, concluiu-se que mães com episódios de depressão gestacional apresentam quase quatro vezes mais chances de ter um filho com baixo peso ao nascer (RP = 3,94; IC: 1,49-10,36. Valendo-se do cálculo da fração atribuível na população, estima-se que, na população geral, 36,17% dos bebês com baixo peso ao nascer são filhos de mães que tiveram episódio depressivo, estimando-se um custo que pode chegar a mais de R$ 76 milhões no Brasil. Sugere-se que se ampliem as ações preventivas e curativas para as gestantes na área da saúde mental, possibilitando melhor desfecho de saúde dos recém-nascidos, e que se utilizem adequadamente os recursos do SUS.Low birth weight is related to morbidity and mortality and sequelae during infant development, thereby impacting health system costs. It is thus important to evaluate factors that influence low birth weight and to estimate their impact on the Brazilian Unified National Health System (SUS. This was a nested prospective study in a cohort of pregnant women who received prenatal care and gave birth in the National Health System in hospitals with ICUs in the city of Pelotas, Rio Grande do Sul State, Brazil. Gestational depression was associated with a fourfold risk of low birth weight (PR = 3.94; CI: 1.49-10.36. Based on the population-attributable fraction, in the overall population an estimated 36.17% of low birth weight infants are born to mothers with an episode of depression during pregnancy, with an estimated cost of more

  8. Genetic Variant rs10757278 on Chromosome 9p21 Contributes to Myocardial Infarction Susceptibility

    Directory of Open Access Journals (Sweden)

    Guangyuan Chen

    2015-05-01

    Full Text Available Large-scale genome-wide association studies (GWAS have revealed that rs10757278 polymorphism (or its proxy rs1333049 on chromosome 9p21 is associated with myocardial infarction (MI susceptibility in individuals of Caucasian ancestry. Following studies in other populations investigated this association. However, some of these studies reported weak or no significant association. Here, we reevaluated this association using large-scale samples by searching PubMed and Google Scholar databases. Our results showed significant association between rs10757278 polymorphism and MI with p = 6.09 × 10−22, odds ratio (OR = 1.29, 95% confidence interval (CI 1.22–1.36 in pooled population. We further performed a subgroup analysis, and found significant association between rs10757278 polymorphism and MI in Asian and Caucasian populations. We identified that the association between rs10757278 polymorphism and MI did not vary substantially by excluding any one study. However, the heterogeneity among the selected studies varies substantially by excluding the study from the Pakistan population. We found even more significant association between rs10757278 polymorphism and MI in pooled population, p = 3.55 × 10−53, after excluding the study from the Pakistan population. In summary, previous studies reported weak or no significant association between rs10757278 polymorphism and MI. Interestingly, our analysis suggests that rs10757278 polymorphism is significantly associated with MI susceptibility by analyzing large-scale samples.

  9. rs3806268 of NLRP3 gene polymorphism is associated with the development of primary gout.

    Science.gov (United States)

    Deng, Jianping; Lin, Wen; Chen, Yunpeng; Wang, Xin; Yin, Zhong; Yao, Chunhong; Liu, Tangbing; Lv, Yonghong

    2015-01-01

    The aim of the present study was to investigate the association between seven functional SNPs in NALP3 gene and the susceptibility to primary gout. A total of 247 patients with primary gout and 247 controls were selected in this study. Genotyping of NALP3 rs4612666, rs3806268, rs12239046, rs10754558, rs7512998, rs12137901 and rs12565738 was performed using the Sequenom MassARRAY platform. Comparison analysis showed that primary gout patients were more likely to have a higher body mass index, DBP, SBP, TG, urea nitrogen and uric acid (P gout when compared with the AA genotype (OR=1.83, 95% CI=1.03-3.26). However, no significant associations were identified for the remaining SNPs. In conclusion, we found a significant association between rs3806268 in NLRP3 gene and the risk of primary gout in a Chinese population. Further clinical and genetic studies are required to investigate the mechanisms underlying the association between NALP3 polymorphisms and the development of primary gout.

  10. Association between BDNF-rs6265 and obesity in the Boston Puerto Rican Health Study

    Science.gov (United States)

    The objective of this study is to examine a functional variant (rs6265) in the BDNF gene interacting with dietary intake modulate obesity traits in the Boston Puerto Rican Health Study population. BDNF rs6265 was genotyped in 1147 Puerto Ricans (aged 45-75 years), and examined for association with o...

  11. Lidt om DØRS' selvforståelse: om lønrelationerne i SMEC

    DEFF Research Database (Denmark)

    Harck, Søren H.

    1997-01-01

    at all: if the wage-to-price elasticity is taken to be equal to one (as stipulated by DØRS), the model turns out to imply, even in the long run, an old-fashioned, stable Phillips curve; and if, more realistically, this elasticity is taken to be smaller than one, the error-correction specification by DØRS...

  12. Abundance analysis of the recurrent nova RS Ophiuchi (2006 outburst)

    CERN Document Server

    Das, Ramkrishna

    2015-01-01

    We present an analysis of elemental abundances of ejecta of the recurrent nova RS Oph using published optical and near-infrared spectra during the 2006 outburst. We use the CLOUDY photoionization code to generate synthetic spectra by varying several parameters, the model generated spectra are then matched with the observed emission line spectra obtained at two epochs. We obtain the best fit model parameters through the $\\chi^{2}$ minimization technique. Our model results fit well with observed optical and near-infrared spectra. The best-fit model parameters are compatible with a hot white dwarf source with T$_{BB}$ of 5.5 - 5.8 $\\times$ 10$^{5}$ K and roughly constant a luminosity of 6 - 8 $\\times$ 10$^{36}$ ergs s$^{-1}$. From the analysis we find the following abundances (by number) of elements with respect to solar: He/H = 1.8 $\\pm$ 0.1, N/H = 12.0 $\\pm$ 1.0, O/H = 1.0 $\\pm$ 0.4, Ne/H = 1.5 $\\pm$ 0.1, Si/H = 0.4 $\\pm$ 0.1, Fe/H = 3.2 $\\pm$ 0.2, Ar/H = 5.1 $\\pm$ 0.1, and Al/H = 1.0 $\\pm$ 0.1, all other elem...

  13. Pentatomids associated with different forest species in Itaara, RS, Brazil

    Directory of Open Access Journals (Sweden)

    Ervandil Corrêa Costa

    2010-03-01

    Full Text Available The objective of this study was to determine qualitatively and quantitatively the pentatomid fauna associated with the canopy of different native species during the period from September 2005 to September 2006. Insects were collected from among nine botanical species: Gochnatia polymorpha (Less. (cambará, Eugenia uniflora Berg. (pitangueira, Acca selowiana (Berg Burret (goiaba-da-serra, Psidium cattleianum Sabine (araçá, Baccharis spp., Solanaum mauritianum Scop. (fumo-bravo, Micanea cinerascens Miq. (passiquinho, Calliandra brevipes Bhent. (caliandra, and Schinus molle L. (aroeira located at Rodolfo da Costa Dam in Itaara, RS, Brazil. Samples were taken every two weeks with a conical funnel made of tin plate (2mm, 70cm in diameter at the rim and 63cm in height. One sample per botanical species for each sampling date was taken, by shaking the branches, ten times over the funnel. Samples were sent to the Entomology Laboratory of the Crop Protection Department of the Federal University of Santa Maria, where the material was analyzed. A total of nine Pentatomidae species were identified. Edessa rufomarginata (De Geer, 1773 was the species of highest ocurrence followed by Thyanta humilis (Bergroth, 1891. The botanical species S. mauritianum presented the greatest number of Pentatomidae species, with an occurrence of 26.9%.

  14. The axisymmetric envelopes of RS Cnc and EP Aqr

    CERN Document Server

    Bertre, T Le; Nhung, P T; Winters, J M

    2016-01-01

    We report on observations obtained at IRAM on two semi-regular variable Asymptotic Giant Branch (AGB) stars, RS Cnc and EP Aqr, undergoing mass loss at an intermediate rate of ~ 10^-7 solar mass per year. Interferometric data obtained with the Plateau-de-Bure interferometer (NOEMA) have been combined with On-The-Fly maps obtained with the 30-m telescope in the CO(1-0) and (2-1) rotational lines. The spectral maps of spatially resolved sources reveal an axisymmetric morphology in which matter is flowing out at a low velocity (~ 2 km/s) in the equatorial planes, and at a larger velocity (~ 8 km/s) along the polar axes. There are indications that this kind of morpho-kinematics is relatively frequent among stars at the beginning of their evolution on the Thermally-Pulsing AGB, in particular among those that show composite CO line profiles, and that it might be caused by the presence of a companion. We discuss the progress that could be expected for our understanding of the mass loss mechanisms in this kind of sou...

  15. Brush Seal Arrangement for the RS-68 Turbopump Set

    Science.gov (United States)

    Nunez, D.; Ransom, D.; Prueger, G.

    2006-01-01

    The nature of the RS-68 turbopumps requires that the hydrogen seals separating the pump from the turbine must have extremely low levels of leakage and be contained in small packages. Conventional seal technologies are not able to reasonably satisfy such design requirements. A review of experimental measurements and analysis publications suggests that brush seals are well suited for the design requirements. Brush seals are shown to have less leakage than conventional labyrinth and damper seals and have no adverse effects on the rotordynamics of the machine. The bulk-flow analysis presented by Hendricks et al. is used as a guideline to create a spreadsheet that provides mass flow through the seal and heat generated by the rubbing contact of the bristles on the shaft. The analysis is anchored to published data for LN2 and LH2 leakage tests. Finally, the analysis is used to design seals for both applications. It is observed that the most important analysis parameter is the thickness of the bristle pack and its relationship to seal clearance, lay angle and pressure drop.

  16. Distinct role of the Fas rs1800682 and FasL rs763110 polymorphisms in determining the risk of breast cancer among Han Chinese females

    Science.gov (United States)

    Wang, Meng; Wang, Zheng; Wang, Xi-Jing; Jin, Tian-Bo; Dai, Zhi-Ming; Kang, Hua-Feng; Guan, Hai-Tao; Ma, Xiao-Bin; Liu, Xing-Han; Dai, Zhi-Jun

    2016-01-01

    Background In recent years, studies have demonstrated that polymorphisms in the promoters of Fas and FasL are significantly associated with breast cancer risk. However, the results of these studies were inconsistent. This case–control study was performed to explore the associations between Fas rs1800682 and FasL rs763110 polymorphisms and breast cancer. Materials and methods A hospital-based case–control study of 560 Han Chinese females with breast cancer (583 controls) was conducted. The MassARRAY system was used to search for a possible association between the disease risk and the two single nucleotide polymorphisms, Fas rs1800682 and FasL rs763110. Statistical analyses were performed using SNPStats software to conduct Pearson’s chi-square tests in five different genetic models. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated after adjustment to age and body mass index. PHASE v2.1 software was used to reconstruct all common haplotypes. Results A statistically significant association was found between Fas rs1800682 and increased breast cancer risk (AG vs AA: OR =1.37, 95% CI =1.06–1.78; AA+AG vs GG: OR =1.32, 95% CI =1.04–1.66), and also it was found that the FasL rs763110 polymorphism may decrease the risk. Stratified analyses demonstrated that the rs763110 polymorphism was associated with lower breast cancer risk among postmenopausal females (heterozygote model: OR =0.69, 95% CI =0.49–0.97; dominant model: OR =0.70, 95% CI =0.51–0.96). The T allele of rs763110 was also associated with a decreased risk of lymph node metastasis (allele model: OR =0.75, 95% CI =0.57–0.97) and an increased risk of the breast cancer being human epidermal growth factor receptor 2 positive (allele model: OR =1.37, 95% CI =1.03–1.18). Moreover, haplotype analysis showed that Ars1800682Trs763110 was associated to a statistically significant degree with lower risk of breast cancer (OR =0.70, 95% CI =0.53–0.91). Conclusion These data suggest that

  17. Impact of host IL28B rs12979860, rs8099917 in interferon responsiveness and advanced liver disease in chronic genotype 3 hepatitis C patients.

    Directory of Open Access Journals (Sweden)

    Rushna Firdaus

    Full Text Available BACKGROUND AND AIMS: Genetic polymorphisms near interleukin 28B gene are associated with spontaneous and treatment induced clearance of hepatitis C virus (HCV. Our objective was to evaluate the impact of interleukin 28B single nucleotide polymorphism (rs12979860, rs8099917 variability in HCV genotype 3 infected populations. METHODS: 400 hepatitis C seroreactive patients from different population groups in Eastern and North Eastern part of India were assessed for host and viral genotypic analysis. 83 HCV genotype 3 infected patients were administered pegylated interferon- ribavirin therapy. Viral genotyping was performed using nested reverse transcriptase-PCR followed by direct sequencing methods. Host interleukin 28B genotyping was performed using real-time PCR based single nucleotide polymorphism analysis. RESULTS: Out of 400 hepatitis C seroreactive individuals, 73.25% were found to be RNA positive. HCV genotype 3 (65.87% was found to be the major circulating strain in this region followed by genotype 1 (32.08%. rs12979860 CC genotype was significantly associated with sustained virological response in HCV genotype 3 infected population. In patients achieving rapid virological response, favourable CC/TT allele at rs12979860, rs8099917 was found to be predominant at both the alleles at 77%, 73.2% respectively; whereas in case of patients with relapsed HCV infection CT, TG alleles were found to be predominant. Additionally, CC genotypes at rs12979860 were found to be associated with sustained virological response in patients with high viral load (OR = 6.75, 0.05rs12979860 TT, rs8099917 GG alleles were present in 34%, 27.6% patients with relapsed HCV infection respectively. Also unfavourable CT, TG genotypes were found to be predominant in patients with advanced stages of liver disease. CONCLUSION: CC, TT the two favourable markers at SNPs rs12979860 and rs8099917 are strongly associated with sustained virological response

  18. An association study between DLGAP1 rs11081062 and EFNA5 rs26728 polymorphisms with obsessive–compulsive disorder in a Chinese Han population

    Directory of Open Access Journals (Sweden)

    Li J

    2015-04-01

    Full Text Available Jiang Li,1 Jiajia Cui,2 Xiuhai Wang,3 Jianhua Ma,4 Haitao Niu,4 Xu Ma,5–7 Xinhua Zhang,2,4 Shiguo Liu8 1Physiatry Department, The Affiliated Hospital of Qingdao University, 2Department of Psychiatry, 3Department of Genetics, Medical College, Qingdao University, 4The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 5Graduate School, Peking Union Medical College, 6National Research Institute for Family Planning, 7World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, People’s Republic of China; 8Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China Background: A recent genome-wide association study indicated that the single nucleotide polymorphisms (SNPs rs11081062 in DLGAP1 and rs26728 in EFNA5 were associated with obsessive–compulsive disorder (OCD in Caucasians. The present case–control association study assessed the global relevance of these two SNPs with respect to OCD subtypes in a Chinese Han population. Methods: We recruited 320 OCD patients and 431 age- and sex-matched controls from a Chinese Han population. rs11081062 and rs26728 SNPs were genotyped by real-time TaqMan polymerase chain reaction, and the chi-squared test was used to compare allele and genotype frequencies of variants between the two groups. Results: No significant differences were found in allele or genotype frequencies of DLGAP1 rs11081062 and EFNA5 rs26728 between the OCD and control groups. Moreover, consistently negative results were observed when classifying by sex, onset age, and comorbidity. However, on analyzing OCD subphenotypes, significant associations were observed between rs11081062 and the presence of contamination obsessions and cleaning compulsions (χ2=7.724, P=0.021 by genotype; χ2=3.745, P=0.053 by allele; and χ2=0.821, P=0.365 by genotype, χ2=27.809, P=0.000 by allele, respectively, and rs26728 with the presence of

  19. Can mothers rely on the Brazilian health system for their deliveries? An assessment of use of the public system and out-of-pocket expenditure in the 2004 Pelotas Birth Cohort Study, Brazil

    Directory of Open Access Journals (Sweden)

    Bertoldi Andréa D

    2008-03-01

    Full Text Available Abstract Background In a country where comprehensive free health care is provided via a public health system (SUS, an unexpected high frequency of catastrophic out-of-pocket expenditure has been described. We studied how deliveries were financed among mothers of a birth cohort and whether they were an important source of household out-of-pocket expenditure. Methods All deliveries occurring in the city of Pelotas, Brazil, during 2004, were recruited for a birth cohort study. All mothers were interviewed just after birth and three months later. Comprehensive data on the pregnancy, delivery, birth conditions and newborn health were collected, along with detailed information on expenses related to the delivery. Results The majority of the deliveries (81% were financed by the public health system, a proportion that increased to more than 95% among the 40% poorest mothers. Less than 1% of these mothers reported some out-of-pocket expenditure. Even among those mothers covered by a private health plan, nearly 50% of births were financed by the SUS. Among the 20% richest, a third of the deliveries were paid by the SUS, 50% by private health plans and 17% by direct payment. Conclusion The public health system offered services in quantity and quality enough to attract even beneficiaries of private health plans and spared mothers from the poorest strata of the population of practically any expense.

  20. Excesso de peso/obesidade no ciclo da vida e composição corporal na idade adulta: coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1982

    Directory of Open Access Journals (Sweden)

    Gabriela Callo

    2016-01-01

    Full Text Available Resumo: O presente estudo teve por objetivo avaliar a associação entre sobrepeso/obesidade em diferentes momentos do ciclo vital com a composição corporal em adultos jovens. Foram utilizados dados da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1982, que tem acompanhado, em diferentes idades, os nascidos vivos cuja família residia na zona urbana da cidade. Aos 30 anos, 3.701 participantes da coorte foram entrevistados, e a composição corporal foi avaliada usando-se o Bod Pod, 2.219 membros da coorte apresentavam, pelo menos, uma medida de peso e altura nos três períodos (infância, adolescência e vida adulta, 24% nunca apresentaram sobrepeso, e 68,6% nunca foram considerados como sendo obesos. Os maiores valores de índice de massa corporal (IMC e de percentual de massa gorda aos 30 anos foram observados naqueles que foram considerados como tendo sobrepeso nos três períodos ou na adolescência e na idade adulta, enquanto que aqueles com sobrepeso/obesidade apenas na infância ou na adolescência tiveram médias de IMC e percentual de massa gorda similares daqueles que nunca apresentaram sobrepeso/obesidade. Os resultados indicam o benefício da interrupção precoce do sobrepeso/obesidade.

  1. História e educação: as relações de gênero em Pelotas no final do século 19 e início do século 20

    Directory of Open Access Journals (Sweden)

    Eliane Teresinha Peres

    2012-07-01

    Full Text Available  Entendendo gênero como elemento constitutivo das relações sociais, a partir da contribuição de Joan Scott, tomo aqui as relações entre homens e mulheres no espaço urbano pelotense no final do século 19 e início do século 20 como foco de análise. Com um corpus de dados empíricos, obtidos em jornais, almanaques, revistas, relatórios do período de estudo, analiso as práticas sociais e culturais de homens e mulheres articulado com suas posições de classe e grupo étnico.Palavras-chave: história, educação, relações de gênero.   Abstract Understanding gender as constitutive element of social relationships, from Joan Scott's contribution, I take here men and women relationships in the urban space of Pelotas in the end of the 19 century and beginning of the 20 century as focus of analysis. With a corpus of empirical data, got in newspapers, almanacs, magazines, reports, of the period in study, I analyze social and cultural practices of men and women articulated with their class position and ethnic group. Keywords: history, education, gender relations.   

  2. Uso de métodos anticoncepcionais e adequação de contraceptivos hormonais orais na cidade de Pelotas, Rio Grande do Sul, Brasil: 1992 e 1999

    Directory of Open Access Journals (Sweden)

    Juvenal Soares Dias-da-Costa

    Full Text Available Realizou-se um estudo transversal de base populacional, com o objetivo de verificar a utilização de métodos contraceptivos e adequação do emprego de anticoncepcionais orais pelas mulheres de 20 a 49 anos, residentes na zona urbana da cidade de Pelotas. Os resultados foram comparados com outro estudo transversal de base populacional, realizado em 1992. Utilizou-se amostragem por conglomerados, incluindo-se 766 mulheres com idade entre 20 e 49 anos. Do total de mulheres, 495 (64,6% utilizavam algum método contraceptivo, sendo mais freqüentemente empregados: anticoncepcionais orais (55,4%, ligadura tubária (22,2%, preservativo (10,5% e dispositivo intra-uterino (7,7%. Entre as usuárias de anticoncepcionais orais, verificou-se que 22,2% apresentavam contra-indicação para seu emprego. O uso incorreto associou-se significativamente à idade, mas foi semelhante entre as classes sociais. Comparando os resultados com aqueles do estudo anterior, destaca-se a redução no emprego de anticoncepcionais orais, e maior freqüência de ligaduras, uso de preservativos e dispositivos intra-uterinos.

  3. 基于proteus的RS232物理接口仿真

    Institute of Scientific and Technical Information of China (English)

    刘兴宾

    2007-01-01

    RS232接口以其简捷的通信协议在电子系统中得到了广泛的使用,proteus下的RS232接口模型的索引号为COMPIM,在仿真电路运行时,该模型会与计算机对应的RS232 9针物理接口建立起联系。在电子技术中,RS232接口的每个针脚都有其特殊的定义。以计算机端的RS232 9针接口为例,其中TXD为串行数据发送线,RXD为串行数据接收线,

  4. Descrição metodológica do uso de acelerometria para mensurar a prática de atividade física nas coortes de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993 e 2004 Descripción metodológica del uso de acelerómetros para medir la actividad física en las cohortes de nacimiento de Pelotas, Rio Grande do Sul, Brasil, 1993 y 2004 Methodological description of accelerometry for measuring physical activity in the 1993 and 2004 Pelotas (Brazil birth cohorts

    Directory of Open Access Journals (Sweden)

    Inácio Crochemore Mohnsam da Silva

    2013-03-01

    Full Text Available O objetivo deste trabalho é caracterizar a metodologia de coleta de atividade física por meio de acelerometria nas coortes de nascidos em 2004 e 1993 em Pelotas, Rio Grande do Sul, Brasil, nos acompanhamentos dos 6-7 e 18 anos, respectivamente. Ao visitarem a sede para um amplo estudo de saúde, esses indivíduos receberam o acelerômetro e a posterior busca foi realizada no domicílio por meio de motociclistas da equipe de pesquisa. Os modelos utilizados foram o GENEA e GENEActiv, estimadores triaxiais da aceleração da gravidade (g, utilizados no punho de crianças e adolescentes por um período de 5 a 8 dias. O número de indivíduos com dados de acelerometria nas coortes foi de 3.331 crianças (93,7% do acompanhamento e 3.816 jovens (92,9% do acompanhamento. Ao caracterizarmos a coleta de acelerometria em mais de 7.000 indivíduos, apresenta-se um arcabouço metodológico para o planejamento de novos estudos populacionais no tema, descrevendo situações específicas dessa experiência e qualificando a compreensão da atividade física no contexto de estudos epidemiológicos.El objetivo de este estudio es caracterizar la metodología de recolección de la actividad física por acelerometría en las cohortes de nacidos en 2004 y 1993 en Pelotas, Río Grande do Sul, Brasil, en un seguimiento de 6-7 y 18, respectivamente. Al visitar la sede de un centro de salud general, estos sujetos recibieron el acelerómetro y la posterior encuesta en el domicilio se llevó a cabo por los responsables del equipo de investigación. Los modelos utilizados fueron el Genea y GENEActiv, estimadores triaxiales de la aceleración de la gravedad (g, que se utilizaron en niños y adolescentes durante un período de 5 a 8 días. El número de individuos con datos de acelerometría en las cohortes fue de 3.331 niños (93,7% de seguimiento y 3.816 jóvenes (92,9% de seguimiento. Con el fin de caracterizar la recolección de acelerometría en más de 7.000 individuos

  5. Genetic Association of CHAT rs3810950 and rs2177369 Polymorphisms with the Risk of Alzheimer’s Disease: A Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Yong Liu

    2016-01-01

    Full Text Available Choline acetyltransferase (CHAT rs3810950 and rs2177369 polymorphisms have been implicated in susceptibility to Alzheimer’s disease (AD. Due to the inconsistent results from previous studies, a meta-analysis was performed to estimate the association between these polymorphisms and AD risk more precisely. Pooled results of our meta-analysis indicated CHAT rs2177369 polymorphism was correlated with decreasing AD risk in one of five genetic models (dominant: OR = 0.77, 95% CI: 0.62–0.96, while rs3810950 mutant was associated with AD development in three models (allelic: OR = 1.18, 95% CI: 1.01–1.37, homozygous: OR = 1.63, 95% CI: 1.09–2.42, and recessive: OR = 1.65, 95% CI: 1.20–2.26. In subgroup analysis by ethnicity, the association between CHAT rs3810950 polymorphism and AD risk was just found in the recessive model (OR = 1.47, 95% CI: 1.05–2.07 among Caucasians, while four genetic models (allelic: OR = 1.23, 95% CI: 1.01–1.48; homozygous: OR = 2.24, 95% CI: 1.48–3.39; dominant: OR = 1.21, 95% CI: 1.06–1.40; and recessive: OR = 2.18, 95% CI: 1.45–3.29 assumed this association in Asians. In conclusion, our meta-analysis indicated CHAT rs2177369 polymorphism might play a protective role in AD, while rs3810950 variant was a risk factor for AD but its single heterozygous mutations might not influence susceptibility to AD.

  6. Relationships between FTO rs9939609, MC4R rs17782313, and PPARγ rs1801282 polymorphisms and the occurrence of selected metabolic and hormonal disorders in middle-aged and elderly men – a preliminary study

    Directory of Open Access Journals (Sweden)

    Rotter I

    2016-11-01

    Full Text Available Iwona Rotter,1 Karolina Skonieczna-Żydecka,2 Danuta Kosik-Bogacka,3 Grażyna Adler,2 Aleksandra Rył,4 Maria Laszczyńska4 1Department of Medical Rehabilitation, 2Department of Gerontobiology, 3Department of Biology and Medical Parasitology, 4Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin, Poland Purpose: Metabolic disorders, including MetS, obesity, and lipid disorders, may be related to genetic factors. Metabolic disorders are associated with decreased TS levels in aging men. The aim of this study was to evaluate the relationship between FTO rs9939609, MC4R rs17782313, and PPARɣ rs1801282 polymorphisms and the presence of MetS and its components, the concurrent lipid disorders, as well as sex hormone concentrations. Subjects and methods: This study involved 272 men of Caucasian descent aged 50–75 years. Lipid profile, including TCh, LDL, HDL, and TG, was evaluated by spectrophotometric method. Anthropometric measurements concerned WC and blood pressure. MetS was diagnosed according to the criteria of the IDF. Sex hormone profile, including TST, FTS, E2, DHEAS, and SHBG, was examined using enzyme-linked immunosorbent assay. Polymorphisms within FTO, MC4R, and PPARɣ genes were identified using polymerase chain reaction-restriction fragments length polymorphism. Results: This study did not show links between the analyzed genetic polymorphisms and the presence of MetS, T2DM, HT, and obesity. However, higher concentrations of TCh and LDL were found in men with the FTO rs9939609 polymorphism in the recessive mode of inheritance (P=0.03 and P=0.05, respectively. Lower WC was found to be associated with MC4R rs17782313 gene inherited in the same model (P=0.005. Conclusion: FTO rs9939609, MC4R rs17782313, and PPARɣ rs1801282 polymorphisms seem to have little effect on the incidence of metabolic malfunctions and no effect on androgen-related disorders in the examined middle-aged and elderly men

  7. Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss%前动力蛋白受体(PKR1 rs4627609和 PKR2 rs6053283)的多态性与复发性流产的关系

    Institute of Scientific and Technical Information of China (English)

    Yun-lei CAO; Zhao-feng ZHANG; Jian WANG; Mao-hua MIAO; Jian-hua XU; Yue-ping SHEN; Ai-min CHEN; Jing DU; Wei YUAN

    2016-01-01

    目的:研究前动力蛋白受体PKR1 rs4627609和PKR2 rs6053283的多态性与复发性流产的关系,并对其可能的作用机制进行预测。创新点:首次在中国汉族人群中进行前动力蛋白受体PKR1 rs4627609和PKR2 rs6053283的多态性与复发性流产关系的研究,并对其功能进行预测。方法:共收集了93例复发性流产和169例健康对照者血液样本,提取基因组DNA,对PKR1 rs4627609和PKR2 rs6053283两个位点进行基因多态性分析,在两组样本中分析不同基因型与复发性流产的关系,并对PKR2 rs6053283位点的不同等位基因进行生物功能预测。结论:PKR2 rs6053283的多态性与复发性流产相关;而PKR1 rs4627609的多态性与复发性流产之间不存在相关性。%Recurrent pregnancy loss (RPL) is a condition with complex etiologies, to which both genetic and envi-ronmental factors may contribute. During the last decade, studies indicated that the expression patterns of the pro-kineticin receptor (PKR1 and PKR2) are closely related to early pregnancy. However, there are few studies on the role of PKR1 and PKR2 in RPL. In this study, we purpose to investigate the association between polymorphisms of the prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and RPL on a group of 93 RPL cases and 169 healthy controls. Genotyping of the single nucleotide polymorphisms (SNPs) was performed using a Sequenom MassARRAY iPLEX system. The results revealed a significant association between PKR2 rs6053283 polymorphism and RPL (P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population.

  8. Permanent active longitudes and activity cycles on RS CVn stars

    Science.gov (United States)

    Berdyugina, Svetlana V.; Tuominen, Ilkka

    1998-08-01

    A new analysis of the published long-term photometric observations has revealed permanent active-longitude structures in four RS CVn stars: EI Eri, II Peg, sigma Gem, and HR 7275. Two active longitudes separated by half of the period are found to dominate on the surface during all available seasons. The positions of the longitudes on three stars (EI Eri, II Peg, HR 7275) are migrating in the orbital reference frame, and there is no preferred orientation with respect to the line of centres in the binaries. The rate of migration is approximately constant. In case of sigma Gem the active longitude migration is synchronized with the orbital motion in the direction of the line of centres in the binary. The active region lifetimes can be longer than the time span of the observations (>=15 yr). The periods of the active longitude rotation are determined: for EI Eri 1fd 9510, for II Peg 6fd 7066, for sigma Gem 19fd 604, for HR 7275 28fd 263. Long-term activity cycles of the stars are discovered from the analysis of the relative contribution of the two longitudes to the photometric variability. One longitude is found to be usually more active than the other at a given moment, and the change of the activity level between the longitudes is cyclic with periods of years. The switch of the activity takes a much shorter time, about a few months, similar to the ``flip-flop'' phenomenon found for FK Com stars. Moments of switching are regarded as new tracers of the activity, and total cycles, which return activity to the same longitude, are found to be for EI Eri 9.0 yr, for II Peg 9.3 yr, for sigma Gem 14.9 yr, for HR 7275 17.5 yr.

  9. RS-1100柴油加氢脱硫催化剂的研制%THE DEVELOPMENT OF RS-1100 DIESEL HYDRODESULFURIZATION CATALYST

    Institute of Scientific and Technical Information of China (English)

    王锦业; 丁石; 李会峰; 王哲

    2012-01-01

    采用合适的拟薄水铝石制备氧化铝载体,并以浸渍法制备NiMo/Al2O3催化剂,找到催化剂中适宜的Ni/(Ni+ Mo)原子比,在浸渍液中引入适量的助剂和有机络合剂可以提高NiMo/Al2O3催化剂的活性.采用拉曼光谱和紫外-可见光谱仪对浸渍液进行表征,结果表明:浸渍液中存在杂多酸阴离子[P2 Mo5 O23]6-;络合剂与Ni离子也存在相互作用.通过制备条件优化,研制出高活性加氢脱硫催化剂RS-1100.中型装置评价结果表明,RS-1100催化剂的柴油超深度加氢脱硫活性比工业参比剂RS-1000更高,采用RS-1100催化剂在合适的加氢反应条件下可以生产满足欧Ⅴ排放标准的柴油.%NiMo/A1-2O3 catalyst was prepared by impregnation method using alumina support from appropriate pseudo-boehmite. The effect of Ni/(Ni + Mo) atomic ratio on the activity of NiMo/A1-2O3catalyst was investigated and optimized ratio was acquired. The activity of NiMo/A1-2O3 catalyst could be further improved by adding optimum amount of phosphorus promoter and chelating agent into the impregnation solution. The characterization of said impregnation solution by Raman spectroscopy and UV-Vis spectrophotometer showed that phosphorus-molybdenum heteropolyanions of [P2MO5O23]6- existed in the solution, besides, some interactions between chelating agent and Ni2+cations also happened. By optimizing preparation conditions, RS-1100 hydrodesulfurization catalyst with high activity was developed. The pilot-plant test results show that the activity of RS-1100 catalyst is higher than that of commercial RS-1000 catalyst at ultra-deep hydrodesulfurization stage, whereas, the bulk density of RS-1100 catalyst is lower. Diesel oil meeting European emission standard V can be produced by RS-1100 catalyst under suitable hydrogenation reaction conditions.

  10. Bone mineral density is associated with vitamin D related rs6013897 and estrogen receptor polymorphism rs4870044: The Tromsø study

    Science.gov (United States)

    Jorde, Rolf; Emaus, Nina; Eggen, Anne Elise; Joakimsen, Ragnar Martin; Kamycheva, Elena

    2017-01-01

    Background Bone mineral density (BMD) is determined by bone remodeling processes regulated by endocrine, autocrine and genetic mechanisms. Thus, some studies have reported that BMD is associated with single nucleotide polymorphisms (SNPs) associated with vitamin D receptor (VDR), serum 25(OH)D levels and estrogen receptor 1 (ESR1), but without consensus. Therefore, we aimed to map and compare the risk genotypes for forearm and total hip low BMD. Methods and findings Data were derived from a population-based study in northern Norway; the Tromsø Study. Distal forearm BMD was measured with a single x-ray absorptiometric device, while total hip BMD was measured with a dual-energy x-ray absorptiometric device. There were 7,317 and 4,082 successful analyses of distal forearm and total hip BMD, respectively, and at least one SNP of interest. We evaluated plausible BMD modulating factors and associations of BMD and SNPs related to vitamin D metabolism (FokI, Cdx2, BsmI, rs2298850, rs10741657, rs3794060, rs6013897), ApaI-BsmI-TaqI haplotypes and ESR1 SNP rs4870044. Results Age, BMI, physical activity and smoking were significantly associated with BMD. In a linear regression model with adjustment for age and gender and with the major homozygote as reference, rs6013897 had a standardized beta coefficient (β) of –0.031 (P = 0.024) for total hip BMD. β for ESR1 SNP rs4870044 was –0.016 (P = 0.036) for forearm BMD and –0.034 (P = 0.015) for total hip BMD. The other SNPs nor serum 25(OH)D were significantly associated with BMD. Conclusions Both forearm and total hip BMD were associated with ESR1 SNP rs4870044. Of the vitamin D–related genes, only CYP24A1 gene rs6013897 was associated with total hip BMD, but the association was weak and needs confirmation in other studies. Serum 25(OH)D was not associated with BMD in our population, probably due to the generally sufficient vitamin D levels in the population. PMID:28253304

  11. Association of ADORA1 rs2228079 and ADORA2A rs5751876 Polymorphisms with Gilles de la Tourette Syndrome in the Polish Population.

    Directory of Open Access Journals (Sweden)

    Piotr Janik

    Full Text Available Gilles de la Tourette syndrome (GTS is a neurodevelopmental disorder characterized by motor and vocal tics. Hyperactivity of dopaminergic transmission is considered a prime abnormality in the pathophysiology of tics. There are reciprocal antagonistic interactions between adenosine and dopamine transmission. The aim of the study was to analyze the association of two polymorphisms, rs2228079 in ADORA1 and rs5751876 in ADORA2A, with the risk of GTS and co-morbid disorders.A total of 162 Polish GTS patients and 270 healthy persons were enrolled in the study. Two polymorphisms were selected on the basis of knowledge of SNPs frequencies in ADORA1 and ADORA2A. Chi-square test was used for allelic and genotypic association studies. Association of genotypes with age of tic onset was analyzed with Mann-Whitney test. Multivariate logistic regression was used to find independent predictors of GTS risk.We found that the risk of GTS was associated with rs2228079 and rs5751876 polymorphisms. The GG+GT genotypes of rs2228079 in ADORA1 were underrepresented in GTS patients (p = 0.011, whereas T allele of rs5751876 in ADORA2A was overrepresented (p = 0.017. The GG genotype of rs2228079 was associated with earlier age of tic onset (p = 0.046. We found also that the minor allele G of rs2228079 was more frequent in GTS patients with depression as compared to the patients without depression (p = 0.015. Also the genotype GG was significantly more frequent in patients with obsessive compulsive disorder/behavior (OCD/OCB, p = 0.021 and depression (p = 0.032, as compared to the patients without these co-morbidities. The minor allele T frequency of rs5751876 was lower in GTS patients with co-morbid attention deficit hyperactivity disorder (p = 0.022, and TT+TC genotypes were less frequent in the non-OCD anxiety disorder group (p = 0.045.ADORA1 and ADORA2A variants are associated with the risk of GTS, co-morbid disorders, and may affect the age of tic onset.

  12. Pioneering better science through the 3Rs: an introduction to the national centre for the replacement, refinement, and reduction of animals in research (NC3Rs).

    Science.gov (United States)

    Burden, Natalie; Chapman, Kathryn; Sewell, Fiona; Robinson, Vicky

    2015-03-01

    The National Centre for the Replacement, Refinement, and Reduction of Animals in Research (NC3Rs) is an independent scientific organization that is based in the United Kingdom, which was set up by the government to lead the discovery and application of new technologies and approaches that minimize the use of animals in research and improve animal welfare. The NC3Rs uses a range of strategies to improve and advance science through application of the 3Rs. These include funding basic research, open innovation (CRACK IT), and programs run by inhouse scientists. We present several case studies from the NC3Rs portfolio, featuring asthma research, the use of nonhuman primates in monoclonal antibody development, and CRACK IT. Finally, we anticipate the future, as we use our experience to move into new research fields and expand toward international collaboration. Here we highlight how equipping scientists with relevant and emerging 3Rs tools can help overcome the challenges and limitations of the use of animals in research to the benefit of the whole bioscience community.

  13. Meta-Analysis of Low Density Lipoprotein Receptor (LDLR rs2228671 Polymorphism and Coronary Heart Disease

    Directory of Open Access Journals (Sweden)

    Huadan Ye

    2014-01-01

    Full Text Available Low density lipoprotein receptor (LDLR can regulate cholesterol metabolism by removing the excess low density lipoprotein cholesterol (LDL-C in blood. Since cholesterol metabolism is often disrupted in coronary heart disease (CHD, LDLR as a candidate gene of CHD has been intensively studied. The goal of our study is to evaluate the overall contribution of LDLR rs2228671 polymorphism to the risk of CHD by combining the genotyping data from multiple case-control studies. Our meta-analysis is involved with 8 case-control studies among 7588 cases and 9711 controls to test the association between LDLR rs2228671 polymorphism and CHD. In addition, we performed a case-control study of LDLR rs2228671 polymorphism with the risk of CHD in Chinese population. Our meta-analysis showed that rs2228671-T allele was significantly associated with a reduced risk of CHD (P=0.0005, odds ratio (OR = 0.83, and 95% confidence interval (95% CI = 0.75–0.92. However, rs2228671-T allele frequency was rare (1% and was not associated with CHD in Han Chinese (P=0.49, suggesting an ethnic difference of LDLR rs2228671 polymorphism. Meta-analysis has established rs2228671 as a protective factor of CHD in Europeans. The lack of association in Chinese reflects an ethnic difference of this genetic variant between Chinese and European populations.

  14. Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

    Science.gov (United States)

    Ranade, Ranae M.; Zhang, Zhongsheng; Dranow, David M.; Myers, Janette B.; Choi, Ryan; Nakazawa Hewitt, Steve; Edwards, Thomas E.; Davies, Douglas R.; Lorimer, Donald; Boyle, Stephen M.; Barrett, Lynn K.; Buckner, Frederick S.; Fan, Erkang; Van Voorhis, Wesley C.

    2016-01-01

    We investigated Brucella melitensis methionyl-tRNA-synthetase (BmMetRS) with molecular, structural and phenotypic methods to learn if BmMetRS is a promising target for brucellosis drug development. Recombinant BmMetRS was expressed, purified from wild type Brucella melitensis biovar Abortus 2308 strain ATCC/CRP #DD-156 and screened by a thermal melt assay against a focused library of one hundred previously classified methionyl-tRNA-synthetase inhibitors of the blood stage form of Trypanosoma brucei. Three compounds showed appreciable shift of denaturation temperature and were selected for further studies on inhibition of the recombinant enzyme activity and cell viability against wild type B. melitensis strain 16M. BmMetRS protein complexed with these three inhibitors resolved into three-dimensional crystal structures and was analyzed. All three selected methionyl-tRNA-synthetase compounds inhibit recombinant BmMetRS enzymatic functions in an aminoacylation assay at varying concentrations. Furthermore, growth inhibition of B. melitensis strain 16M by the compounds was shown. Inhibitor-BmMetRS crystal structure models were used to illustrate the molecular basis of the enzyme inhibition. Our current data suggests that BmMetRS is a promising target for brucellosis drug development. However, further studies are needed to optimize lead compound potency, efficacy and safety as well as determine the pharmacokinetics, optimal dosage, and duration for effective treatment. PMID:27500735

  15. Mysterious a6-containing nAChRs: function, pharmacology, and pathophysiology

    Institute of Scientific and Technical Information of China (English)

    Ke-chun YANGU; Guo-zhang JIN; Jie WU

    2009-01-01

    Neuronal nicotinic acetylcholine receptors (nAChRs) are the superfamily of ligand-gated ion channels and widely expressed throughout the central and peripheral nervous systems. nAChRs play crucial roles in modulating a wide range of higher cognitive functions by mediating presynaptic, postsynaptic, and extrasynaptic signaling. Thus far, nine alpha (a2-alO) and three beta ((32, (33, and (34) subunits have been identified in the CNS, and these subunits assemble to form a diversity of functional nAChRs. Although a4(32- and a7-nAChRs are the two major functional nAChR types in the CNS, a6*-nAChRs are abundantly expressed in the midbrain dopaminergic (DAergic) system, including mesocorticolimbic and nigrostriatal pathways, and particularly present in presynaptic nerve terminals. Recently, functional and pharmacological profiles of a6*-nAChRs have been assessed with the use of a6 subunit blockers such as a-conotoxin Mil and PIA, and also by using a6 subunit knockout mice. By modulating DA release in the nucleus accumbens (NAc) and modulating GABA release onto DAergic neurons in the ventral tegmental area (VTA), a6*-nAChRs may play important roles in the mediation of nicotine reward and addiction. Furthermore, a6*-nAChRs in the nigrostriatal DAergic system may be promising targets for selective preventative treatment of Parkinson's disease (PD). Thus, a6*-nAChRs may hold promise for future clinical treatment of human disorders, such as nicotine addiction and PD. In this review, we mainly focus on the recent advances in the understanding of ct6*-nAChR function, pharmacology and pathophysiology.

  16. Design and Realization of CAN and RS232 Transformation Node%CAN与RS232转换节点的设计与实现

    Institute of Scientific and Technical Information of China (English)

    周伟; 程晓红

    2008-01-01

    介绍将CAN总线接口与RS232总线接口相互转换的设计方法和2种总线电平转换关系,实现CAN总线与各模块的接口设计,制定了相应的软硬件设计方案,并给出软件设计流程图以及部分硬件设计原理图.为CAN总线与RS232总线互联提供了一种方法,对CAN总线与RS232总线接口设备的互联和广泛应用的实现具有重要意义.

  17. The CASP8 rs3834129 polymorphism and breast cancer risk in BRCA1 mutation carriers

    OpenAIRE

    2010-01-01

    Abstract The rs3834129 polymorphism, in the promoter of CASP8 gene, has been recently reported as associated with breast cancer risk in the general population, with the minor allele del having a protective effect. Some of the genetic variants found associated with breast cancer risk were reported as risk modifiers in individuals with mutations in BRCA1 and BRCA2 genes. Here, we tested the effect of the rs3834129 del allele on breast cancer risk in BRCA mutation carriers. The rs3834...

  18. CYP1B1 SNP rs1056827,rs1056836基因多态性与乳腺癌关联研究%The research on the relationship between gene polymorphism of CYP1B1 SNP rs1056827,rs1056836 and breast cancer

    Institute of Scientific and Technical Information of China (English)

    田寅; 太史婧华; 荆洪英; 国玉芝; 张志国

    2014-01-01

    目的:研究CYP1B1 SNP rs1056827,rs1056836基因多态性与乳腺癌的关联.方法:应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)检测CYP1B1 SNP rs1056827,rs1056836基因多态性,比较乳腺癌患者组与健康志愿者对照组CYP1B1 SNP rs1056827,rs1056836基因型的分布频率差异及等位基因频率差异.结果:120例乳腺癌患者组和127例健康志愿者对照组CYP1B1 SNP rs1056827基因型分布频率野生型GG为48.33/65.35%,杂合型GT为40.83/29.13%,突变型TT为10.83/5.51%,两组比较x2为7.71,0.01< P<0.05,等位基因频率野生型G为68.75/79.92%,突变型T为31.25/20.08%,两组比较x2为8.11,P<0.01;CYP1B1SNP rs1056836基因型分布频率野生型CC为49.17/66.93%,杂合型CG为37.50/26.77%,突变型GG为13.33/6.29%,两组比较x2为8.70,0.01<P<0.05,等位基因频率野生型C为67.92/80.31%,突变型G为32.08/19.68%,二组比较x2为8.73,P<0.01.结论:乳腺癌患者组与健康志愿者对照组CYP1B1 SNP rs1056827,rs1056836基因型分布频率和等位基因频率差异有显著性,提示乳腺癌的发生可能与CYP1B1 SNP rs1056827,rs1056836基因多态性具有某种关联.

  19. Vulnerabilidade Natural do Solo de Silveira Martins-RS

    Directory of Open Access Journals (Sweden)

    Franciele Francisca Marmentini Rovani

    Full Text Available A análise ambiental, com base nos processos de morfogênese e pedogênese, possibilita informações importantes para a elaboração de políticas públicas visando o uso e ocupação da paisagem de maneira sustentável. Com isso, objetivou-se identificar os diferentes níveis de vulnerabilidade natural à perda de solo do município de Silveira Martins, RS. Foi elaborado um banco de dados espaciais em um ambiente de Sistemas de Informações Geográficas (SIG com auxílio do software Spring. O zoneamento da vulnerabilidade natural à perda de solo foi elaborado com base nas informações referentes à declividade, geomorfologia, geologia e solos de acordo com o grau de vulnerabilidade de cada informação, por meio da álgebra de mapas. Para o território municipal de Silveira Martins identificou-se a ocorrência de cinco classes. Destacam-se as unidades estáveis com predomínio dos processos formadores do solo (38,08% da área municipal, e as unidades moderadamente vulneráveis, prevalecendo os processos erosivos (53,67%. As áreas classificadas como moderadamente vulnerável e vulnerável (8,25%, correspondem a áreas com inclinações superiores a 25º e com formação geológica e geomorfológica menos estáveis. Nas unidades em que predominou a vulnerabilidade natural, sugere-se especial atenção em relação ao meio natural e aos agentes que o influenciam, visando boas práticas sociais associadas às políticas ambientais no processo de tomada de decisões econômicas, possibilitando a valorização e proteção do meio natural.

  20. Investigating the Correlation between rs1049305 and ‏rs10244884 Polymorphisms of AQP-1 Gene and Menorrhagia ‎in Adolescents

    Directory of Open Access Journals (Sweden)

    S Madani

    2014-02-01

    Results: Regarding ‏‎rs1049305, the C minor allele showed more frequency in patients' group‏ (0.47 vs. 0.37.‎‎ The results revealed that GG genotype presents less probable risk ‎for menorrhagia. ‎‎ rs10244884‎ also shows the same frequency. Conclusion: It can be concluded that both variants are important in pathogenesis of menorrhagia and the results confirm the important role of Aquqporin–1 channel in menstruation as well as endometrium physiology.

  1. A mcu-free RS232/485 converter%一种免微控器的RS232/485转换器

    Institute of Scientific and Technical Information of China (English)

    盛琥; 杨景曙

    2005-01-01

    本文介绍了一种无需微控制器控制的RS232/485转换器,实现了纯硬件的收发控制切换以及串口取电功能,从而避免了常规RS232/485转换器需要对微控制器进行软件编程且通用性不好的问题,具有很好的可行性.

  2. Constructing NTP Time Server by GPS Clock's RS232%GPS时钟RS232搭建NTP时钟服务器

    Institute of Scientific and Technical Information of China (English)

    饶鹏

    2015-01-01

    高精度时间基准是许多计算机系统运行基础.GPS时钟能提供稳定的高精度授时,其提供的时间同步方式包括NTP、RS232以及IRIG-B.NTP协议是计算机系统内使用最广泛的网络时间同步协议,通过GPS时钟RS232时间信息搭建NTP时钟服务器,可以实现系统内的时间同步.

  3. The Design and Application of CAN-RS232 Converter %CAN-RS232转换器的设计与实现

    Institute of Scientific and Technical Information of China (English)

    周述良

    2011-01-01

    本文介绍了基于80C51的CAN-RS232转换器的设计与实现.给出了转换器的硬件接口电路的原理图和软件实现的流程图.探讨了其硬件设计结构和软件部分中初始化模块、CAN通信接口模块和RS232通信接口模块的设计思路.

  4. 嵌入式RS232/Internet网关的设计与实现%Design and implementation of an embedded RS232/internet gateway

    Institute of Scientific and Technical Information of China (English)

    高福祥; 曹杰; 崔秀丽; 高渲

    2006-01-01

    本文阐述嵌入式RS232/Internet网关的硬、软件设计和实现.首先介绍网关的功能;其次介绍以单片机和以太网控制器RTL8019AS为核心搭建的硬件结构;最后详细介绍了软件设计.嵌入式网关主要完成具有RS232接口的设备通过Internet传送数据的问题.

  5. GPIB与RS232/485和并行口转换器的设计%GPIB-RS232/485/Parallel Port Converter

    Institute of Scientific and Technical Information of China (English)

    马永锋; 商庆华; 李东滨; 马怀俭

    2000-01-01

    针对国内带GPIB接口仪器较少,不便于组建总线式自动测试系统的现状,利用80C32,PSD311等单片机系统,设计了一种GPIB与RS232/485和并行口之间的转换器,使之能够将带RS232/485和并行口的仪器接入GPIB总线系统.实践结果表明:该转换器结构简单,功能完善,操作方便.

  6. Interleukin-6 (IL-6)-597 A/G (rs1800797) & -174 G/C (rs1800795) gene polymorphisms in type 2 diabetes

    OpenAIRE

    2014-01-01

    Background & objectives: Diabetes is a metabolic pro-inflammatory disorder characterized by chronic hyperglycaemia and increased levels of circulating cytokines suggesting a causal role for inflammation in its aetiology. In order to decipher the role of interleukin-6 (IL-6) in type 2 diabetes mellitus (T2DM) we analyzed two promoter polymorphisms -597 A/G (rs1800797) and -174 G/C (rs1800795) in T2DM cases from north India, and in healthy controls. Methods: DNA was isolated from venous bl...

  7. The rs4646 and rs12592697 Polymorphisms in CYP19A1 Are Associated with Disease Progression among Patients with Breast Cancer from Different Racial/ethnic Backgrounds.

    Directory of Open Access Journals (Sweden)

    Reina Armamento-Villareal

    2016-12-01

    Full Text Available Given the racial/ethnic disparities in breast cancer, we evaluated the association between CYP19A1 single nucleotide polymorphisms (SNPs on disease progression in women with breast cancer from different racial/ethnic backgrounds. This is a cross-sectional analysis of data from 327 women with breast cancer in the Expanded Breast Cancer Registry program of the University of New Mexico. Stored DNA samples were analyzed for CYP19A1 SNPs using a custom designed microarray panel. Genotype-phenotype correlations were analyzed. Of the 384 SNPs, 2 were associated with clinically significant outcomes, the rs4646 and rs12592697. The T allele for the rs4646 was associated with advanced stage of the disease at the time of presentation (odds ratio OR:1.8, confidence intervals CI: 1.05-3.13, p<0.05 and a more progressive disease (OR: 2.1 CI: 1.1-4.0, p=0.04. For the rs12592697, the variant T allele was more frequent in Hispanic women and associated with a more progressive disease (OR: 2.05 CI: 1.0-4.0, p=0.04. However, further analysis according to menopausal status showed that the association between these 2 SNPs with disease progression or the stage at diagnosis are confined only to postmenopausal women. The odds ratios of disease progression among postmenopausal women carrying the T allele for the rs4646 and rs12592697 are 3.05 (1.21, 7.74, p=0.02 and 3.80 (1.24, 11.6, p=0.02, respectively. Regardless, differences in disease progression among the different genotypes for both SNPs disappeared after adjustment for treatment. In summary, the rs4646 and the rs12592697 SNPs in CYP19A1 are associated with differences in disease progression in postmenopausal women. However, treatment appears to mitigate the differences in genetic risk.ClinicalTrials.govs Identifier: NCT00322894(https://clinicaltrials.gov/ct2/show/NCT00322894?term=new+mexico+breast+cancer+registry&rank=1

  8. Association of rs6265 and rs2030324 polymorphisms in brain-derived neurotrophic factor gene with Alzheimer's disease: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Yan Lin

    Full Text Available BACKGROUND: The association between polymorphisms rs6265 and rs2030324 in brain-derived neurotrophic factor (BDNF and Alzheimer's disease (AD has been widely reported, but the results remain controversial. METHODS: A comprehensive search of Pubmed, Web of Science, China National Knowledge Infrastructure (CNKI, Wanfang Med Online and China Biology Medical literature database (CBM was performed. Pooled odds ratios (ORs with 95% confidence intervals (CIs were calculated using fixed or random-effects models. We excluded the studies with OR>3.0 or OR<0.3 for sensitive analysis. Subgroup analysis by ethnicity, form of AD and gender was carried out. Meta-regression was conducted to explore the potential sources of between-study heterogeneity. RESULTS: 29 articles with 7548 cases and 7334 controls concerning rs6265 and 22 articles with 5796 cases and 5706 controls concerning rs2030324 were included in this meta-analysis. The combined evidence suggested rs6265 contributing significantly to the increased risk of AD in females (codominant: fixed-effects model (FEM: OR = 1.13, 95% CI = 1.04-1.23; dominant: FEM: OR = 1.17, 95% CI = 1.05-1.31, especially for Caucasian females (codominant: FEM: OR = 1.18, 95% CI = 1.03-1.34; dominant: FEM: OR = 1.18, 95% CI = 1.01-1.37 and female late-onset Alzheimer's disease (LOAD patients (codominant: FEM: OR = 1.22, 95% CI = 1.05-1.41; dominant: FEM: OR = 1.23, 95% CI = 1.03-1.46. No evidence indicated an association between rs2030324 with AD in codominant (random-effects model (REM: OR = 1.06, 95% CI = 0.89-1.26 and dominant (REM: OR = 1.05, 95% CI = 0.86-1.27 models. CONCLUSION: This meta-analysis suggested A allele of rs6265 might increase the risk of AD in Caucasian females and female LOAD patients. In addition, no evidence indicated an association between rs2030324 with AD. Further studies are needed to confirm these results.

  9. Determinantes e padrões de utilização da bicicleta e acidentes de trânsito sofridos por ciclistas trabalhadores da cidade de Pelotas, Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Bacchieri Giancarlo

    2005-01-01

    Full Text Available Um estudo transversal de base-populacional foi realizado em Pelotas, sul do Brasil, objetivando pesquisar os determinantes e padrões de utilização da bicicleta como modo de transporte para o trabalho. Foram também descritos os acidentes ocorridos nos últimos 12 meses no deslocamento de ida e volta para o trabalho e a utilização de equipamentos de segurança na bicicleta. A amostra incluiu 1.705 trabalhadores com 15 anos ou mais de idade, residentes na zona urbana, que utilizavam modos de transporte para o trabalho. Análises bruta e ajustada foram realizadas por meio de regressão de Poisson, considerando o efeito do delineamento. A prevalência de utilização da bicicleta foi de 17,2% (IC95%: 15,4-19,0. Trabalhadores homens, com baixa escolaridade e nível econômico mais baixo apresentaram as maiores prevalências. Menos de 1,0% das bicicletas possuía os equipamentos de segurança exigidos pelo Código de Trânsito Brasileiro e 15,0% não tinham freios. Aproximadamente 6,0% desses trabalhadores sofreram acidentes de trânsito com lesões corporais nos últimos 12 meses. Concluímos que trabalhadores que utilizam bicicleta como modo de transporte são prioritários para intervenções preventivas relacionadas a acidentes de trânsito.

  10. Determinantes e padrões de utilização da bicicleta e acidentes de trânsito sofridos por ciclistas trabalhadores da cidade de Pelotas, Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Giancarlo Bacchieri

    Full Text Available Um estudo transversal de base-populacional foi realizado em Pelotas, sul do Brasil, objetivando pesquisar os determinantes e padrões de utilização da bicicleta como modo de transporte para o trabalho. Foram também descritos os acidentes ocorridos nos últimos 12 meses no deslocamento de ida e volta para o trabalho e a utilização de equipamentos de segurança na bicicleta. A amostra incluiu 1.705 trabalhadores com 15 anos ou mais de idade, residentes na zona urbana, que utilizavam modos de transporte para o trabalho. Análises bruta e ajustada foram realizadas por meio de regressão de Poisson, considerando o efeito do delineamento. A prevalência de utilização da bicicleta foi de 17,2% (IC95%: 15,4-19,0. Trabalhadores homens, com baixa escolaridade e nível econômico mais baixo apresentaram as maiores prevalências. Menos de 1,0% das bicicletas possuía os equipamentos de segurança exigidos pelo Código de Trânsito Brasileiro e 15,0% não tinham freios. Aproximadamente 6,0% desses trabalhadores sofreram acidentes de trânsito com lesões corporais nos últimos 12 meses. Concluímos que trabalhadores que utilizam bicicleta como modo de transporte são prioritários para intervenções preventivas relacionadas a acidentes de trânsito.

  11. Preparation and characterization of ketoprofen loaded eudragit RS polymeric nanoparticles for controlled release

    Science.gov (United States)

    Anh, Nguyen Tuan; Chi, Nguyen T.; Khai Tran, T.; Tuyen Dao, T. P.; Nhan Le, N. T.; Mau Chien, Dang; Hoai, Nguyen To

    2012-12-01

    Nanospheres containing ketoprofen (Keto) and polymer eudragit RS were prepared using an emulsion solvent evaporation method. The ultrasonic probe (VCX500, vibracell) was used as a tool to disperse oil phase into aqueous phase leading to water/oil emulsion. Nanoparticles were successfully prepared and their morphologies and diameters were confirmed by transmission electron microscope (TEM) and dynamic light scattering (DLS), respectively. The result showed that particles were spherical with submicron size. The particle size was dependent on the RS concentration, emulsification tools and the types of organic solvents. For the encapsulation ability, Keto-loaded RS nanoparticle showed 9.8% of Keto in nanoparticle, which was evaluated by high-performance liquid chromatography (HPLC). Moreover, the drug release behavior of Keto-loaded eudragit RS nanoparticle was also investigated in vitro at pH 7.4 and compared to referential profenid.

  12. Trails, RS2477, picpts-Project, Published in 2006, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2006. It is described as 'picpts-Project'. Data by this publisher are often...

  13. Trails, RS2477, UnimprovedRoad, Published in 2005, Millard County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2005. It is described as 'UnimprovedRoad'. Data by this publisher are often...

  14. Trails, RS2477, B-Roads83, Published in 2006, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2006. It is described as 'B-Roads83'. Data by this publisher are often provided...

  15. Trails, RS2477, B-Roads83, Published in 2008, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2008. It is described as 'B-Roads83'. Data by this publisher are often provided...

  16. Trails, RS2477, UnimprovedRoadPictures, Published in 2004, Millard County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2004. It is described as 'UnimprovedRoadPictures'. Data by this publisher are...

  17. The role of organizational culture in compliance with the principles of the 3Rs.

    Science.gov (United States)

    Brønstad, Aurora; Berg, Anne-Grethe Trønsdal

    2011-01-01

    In order for their research to be legitimate, scientists carrying out research using animals must comply with rules and regulations. The 3Rs (replacement, reduction and refinement) are one set of guidelines that help to promote the ethical use of animals for research. An important question is whether implementing the principles of the 3Rs in legal regulations, such as a Directive of the European Parliament and of the Council on the protection of animals used for scientific purposes, will increase compliance with the principles of the 3Rs in research organizations. Previous work suggests that organizational culture is just as important for directing behavior as are formalized rules and regulations. This article introduces the concepts of compliance and organizational culture and discusses their consequences on the implementation of the principles of the 3Rs.

  18. Site-specific uv crosslinking of minihelix DNA and TrpRS from Bacillus subtilis

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In order to investigate the recognition mechanism and the relationship between structure and function of minihelix DNA with Tryptophanyl-tRNA Synthetase (TrpRS), TrpRS from Bacillus Subtilis was purified. Four minihelix DNAs were chemically synthesized and the photoreactive reagent s4T was incorporated into three of them at the positions of G73, T72 and T55 corresponding to tRNATrp.The apparatus for uv crossiinking was devised and the parameters for uv crosslinking were optimized. The results indicated that the G73 and T72 base of minihelix DNA interacted with TrpRS directly. The uv crosslinking reaction was improved by the dose of uv irradiation and the concentration of both TrpRS and minihelix DNA.``

  19. Trails, RS2477, centerlines-project, Published in 2006, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2006. It is described as 'centerlines-project'. Data by this publisher are...

  20. Association between polymorphisms of rs194072,rs187269 in GABRB2 gene and first-episode schizophrenia and the efficacy of risperidone%GABRB2基因 rs194072和 rs187269位点遗传多态性与首发精神分裂症及利培酮疗效的关联性研究

    Institute of Scientific and Technical Information of China (English)

    刘延辉; 寇海燕; 王福华; 田博; 张心华

    2015-01-01

    Objective To explore the association between polymorphisms of Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2 ) gene and first-episode schizophrenia,as well as the association with efficacy of risperidone.Methods Polymorphisms of rs194072 and rs187269 in GABRB2 gene was genotyped by using a SYBR Green based real time PCR assay in 277 schizophrenic patients (study group)and 315 healthy controls (control group).Patients in study group were treated with risperidone for 8 weeks and were assessed with Positive and negative Syndrome Scale (PANSS)at baseline and at the end of the treatment.Results There were significant differences in genotypic frequency and allelic frequency of rs194072 (χ2 =7.93,8.64 respectively;P =0.02,0.003 respectively)and rs187269 (χ2 =9.79,8.23 respectively;P =0.008,0.004 respectively) between study group and control group.The haplotype frequency of CC in study group was significantly higher than that in control group (P =0.003)and the haplotype frequency of TT in study group was significantly lower than that in control group (P =0.004).There were significant differences in distribution of genotypes and alleles of rs187269 between patients response to risperidone and patients invalid to risperidone (P =0.003,0.004 respectively).Conclusion The polymorphisms of rs194072 and rs187269 in GABRB2 gene are likely associated with the pathogenesis of schizophrenia and polymorphism of rs187269 is likely associated with the efficacy of risperidone.%目的:探讨γ-氨基丁酸β2受体(GABRB2)基因多态性与首发精神分裂症及其利培酮疗效的相关性。方法采用 SYBR Green I 荧光等位基因特异性实时 PCR 基因分型法完成277例精神分裂症患者(研究组)和315例正常对照者(对照组)的 GABRB2基因 rs194072和 rs187269两个位点多态性的测定。研究组采用利培酮治疗8周,于治疗前及治疗后第8周末用阳性和阴性综合征量表(PANSS)评估疗效。结果两组 rs

  1. Trails, RS2477, TransplanGood, Published in 2007, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2007. It is described as 'TransplanGood'. Data by this publisher are often...

  2. Integrated Application of RS and GIS to Agriculture Land Use Planning

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This paper gives some guidelines of land use planning firstly.A framework of agriculture land use planning is designed based on land use suitability evaluation using integrated technologies of RS and GIS.Further work expected is also given.

  3. Trails, RS2477, ImprovedroadPictures, Published in 2005, Millard County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2005. It is described as 'ImprovedroadPictures'. Data by this publisher are...

  4. Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil Epidemiologia molecular do HIV-1 em Rio Grande, RS, Brasil

    Directory of Open Access Journals (Sweden)

    Ana Maria Barral de Martínez

    2002-10-01

    Full Text Available We conducted a molecular epidemiological study to investigate HIV-1 strains in Rio Grande, southern Brazil, searching for an association with transmission mode and risk behavior. Patients (185 identified at an AIDS treatment reference Hospital, from 1994 to 1997, were included; from which 107 blood samples were obtained. Nested PCR was realized once for each sample; for amplified samples (69 HIV subtypes were classified using the heteroduplex mobility assay. Subtypes identified were B (75%, C (22% and F (3%. All infections with C were diagnosed after 1994. Comparing patients with B and C, no differences were detected regarding demographic, clinical and laboratory characteristics; survival analysis did not reveal differences in HIV to AIDS evolution. A higher proportion of injecting drug users, IDU (not significant, pUm estudo de epidemiologia molecular foi conduzido para investigar subtipos de HIV-1 circulando em Rio Grande, RS, buscando uma associação com modos de transmissão e comportamentos de risco. Pacientes (185 identificados de 1994 a 1997, em um Hospital de referência para o tratamento da AIDS foram incluidos; amostras de sangue foram obtidas de 107. A reação em cadeia da polimerase (PCR foi realizada uma única vez; nas amostras que amplificaram, (69 o subtipo foi classificado pelo ensaio de mobilidade do heteroduplex (HMA. Os subtipos de HIV identificados foram B (75%, C (22% e F (3%. As infecções com C foram diagnosticadas após 1994. Pacientes infectados com B e C não mostraram diferenças (características demográficas, clínicas e laboratoriais; a análise de sobrevida não mostrou diferenças na evolução HIV-AIDS. Maior proporção de usuários de drogas injetáveis (UDI (não significativa, p<0,07, foi identificada entre infectados com C. Este resultado sugere C ter sido introduzido nesta área através dos UDI, sendo transmitido pelos seus parceiros sexuais, a pessoas com outras práticas de risco.

  5. Associação dos polimorfismos rs53576 e rs2254298 do gene receptor da ocitocina com depressão: uma revisão sistemática = Association of oxytocin receptor gene polymorphisms rs53576 and rs2254298 with depression: a systematic review

    Directory of Open Access Journals (Sweden)

    Jacondino, Camila Bittencourt

    2014-01-01

    Conclusões: Os resultados sugerem que os OXTR rs53576 e rs2254298 estão associados a sintomas, temperamento depressivo e depressão. Contudo, é importante levar em consideração que esses polimorfismos não atuam de forma determinística, ou seja, são influenciados ou modulados por condições ambientais, que podem envolver fatores biopsicossociais, afetivos, étnicos e de gênero

  6. 基于AVR单片机CAN总线转RS232的设计

    Institute of Scientific and Technical Information of China (English)

    殷卫峰

    2012-01-01

    本文结合现在监测监控系统的网络化发展需要,采用ATMega16、SJAl000、MCP2551和MAX232,设计开发了CAN总线转RS232的接口,完成了两种协议的转换,实现了CAN总线与RS232设备的全双工通信。

  7. 以太网转RS232转换器的设计

    Institute of Scientific and Technical Information of China (English)

    刘艺

    2015-01-01

    为了实现现有以RS232为通讯方式的设备的网络化监控和管理,提出了以太网转RS232的转换器设计。利用STM32F103实现了对转换器的硬件设计,对软件模块进行了功能划分,利用主程序和中断服务程序对转换器功能进行软件实现。设计的以太网转RS232转换器具有较强的通用性,在不改变硬件平台的情况下,仅对软件的处理模块进行少量修改便能适应各种RS232协议。%In order to monitor and manage the existed device with RS232 communication protocol,Ethernet to RS232 converter design is necessary.The converter hardware design used STM32F103 as the main MCU.Converter software modules were divided by the converter function.Main program and interrupt service program software were designed to achieve the function of the converter.The designed Ethernet to RS232 converter has strong generality.It can only do smal modification in the data handle module to satisfy the variety of RS232 protocol, without change the hardware platform.

  8. 一种RS232-USB通信接口设计方案

    Institute of Scientific and Technical Information of China (English)

    李永珍

    2008-01-01

    本文从理论上讨论了一种RS232-USB通信接口的设计方案,分别从硬件设计、软件设计及系统测试三方面进行了具体分析,为进一步实现RS232-USB通信接口提供了一个解决的思路和方法。

  9. The equivalence between B-W and K-G and R-S equations

    Institute of Scientific and Technical Information of China (English)

    黄时中; 阮图南; 吴宁; 郑志鹏

    2003-01-01

    The equivalence between the Bargmann-Wigner (B-W) equations and the Klein-Gordon (K-G) equations for integral spin, and the Rarita-Schwinger (R-S) equations for half integral spin is established by explicit derivation, starting from the lowest spin cases. It is demonstrated that all the constraints or subsidiary conditions imposed on the K-G or R-S equations are included in the B-W equations.

  10. The gender-specific association of rs334558 in GSK3β with major depressive disorder

    Science.gov (United States)

    Liu, Sha; Wang, Le; Sun, Ning; Yang, Chunxia; Liu, Zhifen; Li, Xinrong; Cao, Xiaohua; Xu, Yong; Zhang, Kerang

    2017-01-01

    Abstract Major depressive disorder (MDD) is one of the most prevalent psychiatric illnesses with a heritability ranging from 40% to 50%. The single nucleotide polymorphism (SNP) rs334558 on the glycogen synthase kinase-3β (GSK3β) gene has been identified as a genetic risk loci associated with schizophrenia and bipolar disorder. However, results from replication studies examining the association between rs334558 and MDD remain inconsistent. In the present study, first, we conducted a meta-analysis of the association between rs334558 and MDD by combining 5 available case-control samples totaling 2311 cases and 2535 controls. Second, genotyping data from patients with MDD at our institution, after further stratification by gender, were analyzed to determine the association between rs334558 and MDD. All studies retrieved and included in the meta-analysis were from Korea and China. The meta-analysis suggested that the functional polymorphism rs334558 within the GSK3β promoter region was associated with MDD risk (P < 0.05). The associations were observed both in the allelic and genetic models. Analysis of the genotyping data extracted from our hospital database revealed that rs334558 exhibited exclusive association with MDD in female patients (P=0.015). Our findings suggest that GSK3β rs334558 polymorphisms might be a potential risk for MDD, and females with GSK3β rs334558 polymorphisms might have higher penetrance of MDD. If validated in larger scale samples and in different ethnic populations, these findings might be of value as diagnostic references for MDD. PMID:28099358

  11. 利用RS232-CAN总线转换器实现多机通讯%A Method of Realization of MCUS' Communication by Using RS232-CAN Bus Converter

    Institute of Scientific and Technical Information of China (English)

    孙飞; 汤俊玲

    2004-01-01

    RS232通讯距离短,而且只能进行点到点通讯,不能直接组建多点通讯网络.为了延长RS232的通讯距离,并将RS232节点组成通讯网络,目前广泛使用RS232/RS485信号转换器.但是,由于RS485通讯本身的局限性,在实际应用中存在许多不足.为此,可以将RS232通讯网络转换成CAN通讯网络,以更好地解决用户建立远程通讯网络的问题.

  12. Heme sensing in Bacillus thuringiensis: a supplementary HssRS-regulated heme resistance system.

    Science.gov (United States)

    Schmidt, Rachel M; Carter, Micaela M; Chu, Michelle L; Latario, Casey J; Stadler, Sarah K; Stauff, Devin L

    2016-05-01

    Several Gram-positive pathogens scavenge host-derived heme to satisfy their nutritional iron requirement. However, heme is a toxic molecule capable of damaging the bacterial cell. Gram-positive pathogens within the phylum Firmicutes overcome heme toxicity by sensing heme through HssRS, a two-component system that regulates the heme detoxification transporter HrtAB. Here we show that heme sensing by HssRS and heme detoxification by HrtAB occur in the insect pathogen Bacillus thuringiensis We find that in B. thuringiensis, HssRS directly regulates an operon, hrmXY, encoding hypothetical membrane proteins that are not found in other Firmicutes with characterized HssRS and HrtAB systems. This novel HssRS-regulated operon or its orthologs BMB171_c3178 and BMB171_c3330 are required for maximal heme resistance. Furthermore, the activity of HrmXY is not dependent on expression of HrtAB. These results suggest that B. thuringiensis senses heme through HssRS and induces expression of separate membrane-localized systems capable of overcoming different aspects of heme toxicity.

  13. Smoking attenuated the association between IκBα rs696 polymorphism and defective spermatogenesis in humans.

    Science.gov (United States)

    Yu, B; Ding, Q; Zheng, T; Jiang, L; Li, Q; Sun, X; Bai, C; Huang, Z

    2015-11-01

    Defective spermatogenesis is prevalent in infertile men, but the molecular mechanisms underlying its aetiology are largely unknown. In this study, a proposed association between IκBα SNPs, smoking-related ROS and sperm quality was investigated. Two polymorphisms in the IκBα gene, rs2233406 and rs696 were genotyped in 342 controls and 338 patients with defective spermatogenesis from a southern Chinese population. The results showed the rs696 AA genotype to be significantly more common (21.60% versus 14.33%, P = 0.013) and the rs696 GG genotype to be significantly rarer (28.99% versus 37.13%, P = 0.024) in the cases than in the controls. After subjects were stratified into smokers and nonsmokers, these differences were only observed in nonsmokers. Further analysis showed the rs696 AA genotype to be significantly closely associated with defective spermatogenesis in all subjects (P = 0.014, OR = 1.647) and in nonsmokers (P = 0.036, OR = 1.889). In a TM3 cell model, exposure to cigarette smoke condensate was found to activate NF-κB luciferase activity and altered transcriptional level of NF-κB pathway genes. In conclusion, this study demonstrates an association between functional polymorphisms of the IκBα rs696 and cigarette smoking with the risk of defective spermatogenesis, suggesting some interaction between the NF-κB signalling pathway and smoking-related ROS in human spermatogenesis.

  14. Association between polymorphism rs6983267 and gastric cancer risk in Chinese population

    Institute of Scientific and Technical Information of China (English)

    Yi Guo; Heng-Jun Gao; Jing Fang; Yan Liu; Hai-Hui Sheng; Xiao-Yan Zhang; Hai-Na Chai; Wei Jin; Ke-Hao Zhang; Chang-Qing Yang

    2011-01-01

    AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk.METHODS: A case-control investigation including212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267,rs7008482 and rs10808555) were examined and establishedthrough polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer.RESULTS: The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype ofrs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Furtherstratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753;OR: 1.916, 95% CI: 1.166-3.150, respectively).CONCLUSION: This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed.

  15. The common variant rs11646213 is associated with preeclampsia in Han Chinese women.

    Directory of Open Access Journals (Sweden)

    Ji-peng Wan

    Full Text Available BACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This study evaluated the association between preeclampsia and rs11646213. METHODS: A total of 454 cases and 460 controls were recruited to participate in this study. The single nucleotide polymorphism (SNP rs11646213 was genotyped by polymerase chain reaction (PCR and direct sequencing. RESULTS: The allele frequency of rs11646213 was significantly different between the preeclampsia and control groups (P = 0.017, OR = 1.36, 95% CI = 1.06-1.76. Differences were particularly significant in the severe preeclampsia subgroup (P = 0.002, OR = 1.54, 95% CI = 1.17-2.03 and the early-onset preeclampsia subgroup (P = 0.004, OR = 1.57, 95% CI = 1.16-2.13. Genotyping analysis showed that the T allele of rs11646213 could confer a risk for preeclampsia, severe preeclampsia and early-onset preeclampsia. CONCLUSIONS: Rs11646213 upstream of the CDH13 gene is associated with preeclampsia in Han Chinese women.

  16. Association Between MIF-AS rs755622 and Nephrolithiasis Risk in a Chinese Population.

    Science.gov (United States)

    Ma, Gaoxiang; Yuan, Qinbo; Wang, Qiangdong; Du, Mulong; Chu, Haiyan; Dong, Zhenjia; Xiao, Xu; Wang, Meilin; Qin, Chao; Yin, Changjun; Zhang, Zhengdong; Zhang, Wei

    2016-02-20

    BACKGROUND Single-nucleotide polymorphisms (SNPs) located at lncRNA may affect the stability and splicing processes of mRNA formation, which result in the alteration of its interacting partners. The SNP rs755622 within exon of antisense lncRNA MIF- AS and promoter of MIF was implicated in renal disease risk. MATERIAL AND METHODS In this case-control study, we genotyped the SNP rs755622 in 230 patients diagnosed with nephrolithiasis and 250 controls in a Chinese population. RESULTS We found that the rs755622 CG and CC genotypes had a significantly increased nephrolithiasis risk (adjusted OR=1.52, 95% CI=1.03-2.25; OR=2.63, 95% CI=1.21-5.72, P=0.015), compared with GG genotype in the additive model. The rs755622 C carriers (GC/CC) had an adjusted OR (95% CI) of 1.65 (1.14-2.39, P=0.016), compared with the GG genotype in the dominant model. This hazardous effect was more pronounced in subgroup age >46, BMI >24, hypertension, ever smoking, and ever drinking subjects. Moreover, we found that rs755622 could modulate the function of MIF-AS by influencing its folding. CONCLUSIONS These results indicate that the MIF-AS rs755622 polymorphism may have a crucial role in the development of nephrolithiasis.

  17. Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor.

    Science.gov (United States)

    Olson, Michael E; Nygaard, Tyler K; Ackermann, Laynez; Watkins, Robert L; Zurek, Oliwia W; Pallister, Kyler B; Griffith, Shannon; Kiedrowski, Megan R; Flack, Caralyn E; Kavanaugh, Jeffrey S; Kreiswirth, Barry N; Horswill, Alexander R; Voyich, Jovanka M

    2013-04-01

    Several prominent bacterial pathogens secrete nuclease (Nuc) enzymes that have an important role in combating the host immune response. Early studies of Staphylococcus aureus Nuc attributed its regulation to the agr quorum-sensing system. However, recent microarray data have indicated that nuc is under the control of the SaeRS two-component system, which is a major regulator of S. aureus virulence determinants. Here we report that the nuc gene is directly controlled by the SaeRS two-component system through reporter fusion, immunoblotting, Nuc activity measurements, promoter mapping, and binding studies, and additionally, we were unable identify a notable regulatory link to the agr system. The observed SaeRS-dependent regulation was conserved across a wide spectrum of representative S. aureus isolates. Moreover, with community-associated methicillin-resistant S. aureus (CA MRSA) in a mouse model of peritonitis, we observed in vivo expression of Nuc activity in an SaeRS-dependent manner and determined that Nuc is a virulence factor that is important for in vivo survival, confirming the enzyme's role as a contributor to invasive disease. Finally, natural polymorphisms were identified in the SaeRS proteins, one of which was linked to Nuc regulation in a CA MRSA USA300 endocarditis isolate. Altogether, our findings demonstrate that Nuc is an important S. aureus virulence factor and part of the SaeRS regulon.

  18. Staphylococcus aureus Nuclease Is an SaeRS-Dependent Virulence Factor

    Science.gov (United States)

    Olson, Michael E.; Nygaard, Tyler K.; Ackermann, Laynez; Watkins, Robert L.; Zurek, Oliwia W.; Pallister, Kyler B.; Griffith, Shannon; Kiedrowski, Megan R.; Flack, Caralyn E.; Kavanaugh, Jeffrey S.; Kreiswirth, Barry N.

    2013-01-01

    Several prominent bacterial pathogens secrete nuclease (Nuc) enzymes that have an important role in combating the host immune response. Early studies of Staphylococcus aureus Nuc attributed its regulation to the agr quorum-sensing system. However, recent microarray data have indicated that nuc is under the control of the SaeRS two-component system, which is a major regulator of S. aureus virulence determinants. Here we report that the nuc gene is directly controlled by the SaeRS two-component system through reporter fusion, immunoblotting, Nuc activity measurements, promoter mapping, and binding studies, and additionally, we were unable identify a notable regulatory link to the agr system. The observed SaeRS-dependent regulation was conserved across a wide spectrum of representative S. aureus isolates. Moreover, with community-associated methicillin-resistant S. aureus (CA MRSA) in a mouse model of peritonitis, we observed in vivo expression of Nuc activity in an SaeRS-dependent manner and determined that Nuc is a virulence factor that is important for in vivo survival, confirming the enzyme's role as a contributor to invasive disease. Finally, natural polymorphisms were identified in the SaeRS proteins, one of which was linked to Nuc regulation in a CA MRSA USA300 endocarditis isolate. Altogether, our findings demonstrate that Nuc is an important S. aureus virulence factor and part of the SaeRS regulon. PMID:23381999

  19. Positive Association between GCKR rs780093 Polymorphism and Coronary Heart Disease in the Aged Han Chinese

    Directory of Open Access Journals (Sweden)

    Jiangfang Lian

    2013-01-01

    Full Text Available Objective. Previous studies have confirmed that GCKR rs780093 polymorphism is associated with triglyceride (TG, a known risk factor of coronary heart disease (CHD. The goal of our study is to explore the association of GCKR rs780093 polymorphism with CHD in Han Chinese population. Methods and Results. A total of 568 CHD cases and 494 non-CHD controls were enrolled in the current case-control study. Genotyping was done using melting temperature shift (Tm-shift approach. Our results also showed that GCKR rs780093 polymorphism was significantly associated with TG level (P=0.0016. Although there was no significant association between cases and controls (P>0.05, a breakdown analysis by age yielded a significant association of GCKR rs780093 polymorphism with CHD in individuals aged 65 and older (genotype: χ2=6.86; df = 2; P=0.03; allele: χ2=4.11; df = 1; P=0.04. Conclusion. Our findings confirmed the contribution of GCKR rs780093 polymorphism to TG metabolism and demonstrated GCKR rs780093 as a risk factor of CHD in individuals aged 65 and older.

  20. Design and Application of Converter between RS232 and CAN%RS232-CAN协议转换器的设计及应用

    Institute of Scientific and Technical Information of China (English)

    邓广福; 刘光达; 周志坚

    2006-01-01

    为解决RS232接口设备传输距离短、不便于组网等问题,根据CAN(Controller Area Network)总线的传输距离远、抗干扰能力强、便于组网等特点,设计了基于CAN总线技术、串行通信技术和单片机技术的RS232-CAN协议转换器,给出了协议转换器的设计原理、软硬件设计方法及实际应用中的注意事项.该转换器使信号的传输距离达到10 km,通信速率可调,可组成具有多达110个节点的多机使用网络,对RS232接口设备及RS232接口设备与CAN接口设备的联机使用有重要意义.

  1. Lack of association of IL6R rs2228145 and IL6ST/gp130 rs2228044 gene polymorphisms with cardiovascular disease in patients with rheumatoid arthritis.

    Science.gov (United States)

    López-Mejías, R; García-Bermúdez, M; González-Juanatey, C; Castañeda, S; Miranda-Filloy, J A; Gómez-Vaquero, C; Fernández-Gutiérrez, B; Balsa, A; Pascual-Salcedo, D; Blanco, R; González-Álvaro, I; Llorca, J; Martín, J; González-Gay, M A

    2011-12-01

    Interleukin-6 (IL-6) is a key mediator of inflammation in rheumatoid arthritis (RA) and its actions may be controlled by the IL-6 receptor (IL-6R). IL-6 transducer (IL-6ST/ gp130) is the signal transducing subunit of the IL-6R. We assessed the influence of the IL6R and the IL6ST/gp130 genes in the risk of cardiovascular (CV) disease in RA. For this purpose, 1250 Spanish patients with RA were genotyped for the IL6R rs2228145 and IL6ST/gp130 rs2228044 functional gene polymorphisms. Patients were stratified according to the presence or absence of CV events. Also, a subgroup of patients without CV events was assessed for the presence of subclinical atherosclerosis using two surrogate markers of atherosclerosis (flow-mediated endothelium-dependent vasodilatation and carotid intima-media thickness). No significant differences in the genotype and allele frequencies for both gene polymorphisms between patients with and without CV events were observed. It was also the case when values of surrogate markers of atherosclerosis were compared according to IL6R and IL6ST genotype frequencies. In conclusion, our results do not confirm an association of IL6R rs2228145 and IL6ST/gp130 rs2228044 polymorphisms with CV disease in RA.

  2. An Xp22.1-p22.2 YAC contig encompassing the disease loci for RS, KFSD, CLS, HYP and RP15 : Refined localization of RS

    NARCIS (Netherlands)

    van de Vosse, E; Bergen, AAB; Meershoek, EJ; Oosterwijk, JC; Gregory, S; Bakker, B; Weissenbach, J; Coffey, AJ; vanOmmen, GJB; DenDunnen, JT

    1996-01-01

    To facilitate the positional cloning of the genes involved in retinoschisis (RS), keratosis follicularis spinulosa decalvans (KFSD), Coffin-Lowry syndrome (CLS), X-linked hypophosphatemic rickets (XLH, locus name HYP) and X-linked dominant cone-rod degeneration (locus name RP 15), we have extended t

  3. Lack of association between KCNJ11 (rs5219 and ABCC8 (rs757110 polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region

    Directory of Open Access Journals (Sweden)

    Irina Arkadyevna Bondar

    2015-03-01

    Full Text Available AimSulfonylureas (SU are widely used in everyday clinical practice in treatment of patients with type 2 diabetes mellitus (T2DM. There is a considerable variability in SU effects, which may be caused by psychological, social, biological and genetic factors. The aim of the study was to investigate the association between rs5219 KCNJ11 gene and rs757110 ABCC8 gene polymorphism and long-term response to SU-drugs of second and third generation in the Novosibirsk region.Materials and Methods326 patients with type 2 diabetes in the Novosibirsk region were examined. Patients were divided into 2 groups, depending on HbA1c level. The first group included patients with target HbA1c levels on SU monotherapy. The second group included patients who did not reach target HbA1c levels on the highest dose of SU. Genotyping of KCNJ11 (rs5219 and ABCC8 (rs757110 was performed by TaqMan real-time PCR (ICBFM SB RAS, Novosibirsk, Russia.ResultsPatients with type 2 diabetes with a good response to SU-therapy compared to the group of patients with a poor response to SU-therapy were older (65.8±9.1 years vs. 61.6±7.9 years, p<0.01, had later onset of type 2 diabetes (59.7±9.2 years vs. 48.3±9.3 years, p <0.01, shorter duration of type 2 diabetes (6.1±4.8 years vs. 13.2±7.3 years, p<0.01 and weak insulin resistance: fasting insulin 9.7±6.9 mU/ml vs. 13.6±12.7 mU/ml (p<0.05, HOMA-IR 3.1±2.2 vs. 6.2±6.0 (p<0.01, triglycerides 1.76±0.83 mmol/l vs. 2.42±1.97 mmol/l (p <0.01. Statistically significant differences between KCNJ11 (rs5219 and ABCC8 (rs757110 genotypes and response to SU-therapy was not found. The frequency of risk allele T polymorphism rs5219 KCNG11 gene in patients with a good response to SU was 0.38 and in the patients with a poor response to SU -0.38 (χ2=0.02, р=0.89. The frequency of the risk allele G polymorphism rs757110 ABCC8 gene in patients with a good response to SU was 0.40 and in the patients with poor response to SU -0.37 (χ2

  4. 8q24 rs6983267G variant is associated with increased thyroid cancer risk

    Science.gov (United States)

    Sahasrabudhe, Ruta; Estrada, Ana; Lott, Paul; Martin, Lynn; Echeverry, Guadalupe Polanco; Velez, Alejandro; Neta, Gila; Takahasi, Meiko; Saenko, Vladimir; Mitsutake, Norisato; Jaeguer, Emma; Duque, Carlos Simon; Rios, Alejandro; Bohorquez, Mabel; Prieto, Rodrigo; Criollo, Angel; Echeverry, Magdalena; Tomlinson, Ian; Carvajal Carmona, Luis G.

    2015-01-01

    The G allele of the rs6983267 single nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in thyroid cancer susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3,067 cases and 8,575 controls. We detected significant associations between rs6983267G and thyroid cancer in the British Isles (Odds Ratio, OR= 1.19, 95% confidence interval, CI: 1.11–1.27, P= 4.03 × 10−7), Japan (OR= 1.20, 95% CI: 1.03–1.41, P= 0.022) and a borderline significant association of similar effect direction and size in Colombia (OR= 1.19, 95% CI: 0.99–1.44, P= 0.069). A meta-analysis of our multi-ethnic study and previously published non-overlapping datasets, which included a total of 5,484 cases and 12,594 controls, confirmed the association between rs6983267G and thyroid cancer (P= 1.23 × 10−7, OR= 1.13, 95% CI: 1.07–1.18). Our results therefore support the notion that rs6983267G is a bona fide thyroid cancer risk variant that increases the risk of disease by ~13%. PMID:26290501

  5. The 8q24 rs6983267G variant is associated with increased thyroid cancer risk.

    Science.gov (United States)

    Sahasrabudhe, Ruta; Estrada, Ana; Lott, Paul; Martin, Lynn; Polanco Echeverry, Guadalupe; Velez, Alejandro; Neta, Gila; Takahasi, Meiko; Saenko, Vladimir; Mitsutake, Norisato; Jaeguer, Emma; Duque, Carlos Simon; Rios, Alejandro; Bohorquez, Mabel; Prieto, Rodrigo; Criollo, Angel; Echeverry, Magdalena; Tomlinson, Ian; Carmona, Luis G Carvajal

    2015-10-01

    The G allele of the rs6983267 single-nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer (TC) has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in TC susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3067 cases and 8575 controls. We detected significant associations between rs6983267G and TC in the British Isles (odds ratio (OR)=1.19, 95% CI: 1.11-1.27, P=4.03×10(-7)), Japan (OR=1.20, 95% CI: 1.03-1.41, P=0.022) and a borderline significant association of similar effect direction and size in Colombia (OR=1.19, 95% CI: 0.99-1.44, P=0.069). A meta-analysis of our multi-ethnic study and previously published non-overlapping datasets, which included a total of 5484 cases and 12 594 controls, confirmed the association between rs6983267G and TC (P=1.23×10(-7), OR=1.13, 95% CI: 1.08-1.18). Our results therefore support the notion that rs6983267G is a bona fide TC risk variant that increases the risk of disease by ∼13%.

  6. Research on texture feature of RS image based on cloud model

    Science.gov (United States)

    Wang, Zuocheng; Xue, Lixia

    2008-10-01

    This paper presents a new method applied to texture feature representation in RS image based on cloud model. Aiming at the fuzziness and randomness of RS image, we introduce the cloud theory into RS image processing in a creative way. The digital characteristics of clouds well integrate the fuzziness and randomness of linguistic terms in a unified way and map the quantitative and qualitative concepts. We adopt texture multi-dimensions cloud to accomplish vagueness and randomness handling of texture feature in RS image. The method has two steps: 1) Correlativity analyzing of texture statistical parameters in Grey Level Co-occurrence Matrix (GLCM) and parameters fuzzification. GLCM can be used to representing the texture feature in many aspects perfectly. According to the expressive force of texture statistical parameters and by Correlativity analyzing of texture statistical parameters, we can abstract a few texture statistical parameters that can best represent the texture feature. By the fuzziness algorithm, the texture statistical parameters can be mapped to fuzzy cloud space. 2) Texture multi-dimensions cloud model constructing. Based on the abstracted texture statistical parameters and fuzziness cloud space, texture multi-dimensions cloud model can be constructed in micro-windows of image. According to the membership of texture statistical parameters, we can achieve the samples of cloud-drop. By backward cloud generator, the digital characteristics of texture multi-dimensions cloud model can be achieved and the Mathematical Expected Hyper Surface(MEHS) of multi-dimensions cloud of micro-windows can be constructed. At last, the weighted sum of the 3 digital characteristics of micro-window cloud model was proposed and used in texture representing in RS image. The method we develop is demonstrated by applying it to texture representing in many RS images, various performance studies testify that the method is both efficient and effective. It enriches the cloud

  7. Correlation of rs6756667 and rs7583392 polymorphism of EPAS1 with high altitude polycythemia in male Han population%EPAS1基因rs6756667及rs7583392多态性与汉族男性高原红细胞增多症的相关性研究

    Institute of Scientific and Technical Information of China (English)

    陈郁; 蒋春华; 罗勇军; 刘福玉; 高钰琪

    2012-01-01

    Objective To investigate the correlation between rs67S6667 and rs7583392 polymorphism of endothelial Per-Arnt-Sim domain protein l(EPASl) and high altitude polycythemia(HAPC) in male Han population. Methods A total of 318 individuals with HAPC and 316 male individuals without HAPC (controls) of Han population were enrolled in this study, and genotypes of rs6756667 and rs7S83392 were identified by polymerase chain reaction-high resolution melting analysis method. Polymorphism data of this study were compared with that collected from Han males in Beijing in the International HapMap Project database and Tibetan population from previous literature. Results Genotypes of AA, AG and GG were found in rs6756667 and rs7583392 polymorphism. The frequencies of the three genotypes of rs67S6667 in HAPC group and control group were 1.9%, 16.0%, 82.1% and 3.2%, 22.8%, 74.0%, respectively. The distribution of genotypes showed significant difference between HAPC group and control group (P=0.049), with frequency of GG genotype in HAPC group was markedly higher than that of control group (P=0.025). The frequencies of A allele and G allele were significantly different between HAPC group and control group (P=0.011, OR=0.64S,95%CI=0.459~0.908). The frequencies of the three genotypes of rs7583392 in HAPC group and control group were 77.7%, 18.6%, 3.7% and 69.0%, 24.0%, 7.0%, respectively, while the frequency distribution of rs7583392 did not match the Hardy-Weinberg equilibrium test. Compared with Han Chinese in Beijing, there was no significant difference in frequency distribution of genotypes or alleles of rs6756667 polymorphism in this study, while statistically significant significance was found as compared with Tibetan population as found from previous literature (X2=76.133, P<0.0001). Conclusion Polymorphism of rs6756667 in EPAS1 is associated with the occurrence of HAPC in male Han population, the A allele may be a protective factor against HAPC, while the genotype of GG may be a

  8. SISTEM MONITORING LAYAR KOMPUTER SECARA REMOTE MENGGUNAKAN JARINGAN MULTIDROP RS 485

    Directory of Open Access Journals (Sweden)

    Irwan Kristanto

    1999-01-01

    Full Text Available Serial communication is commonly used in PC interface, but serial communication that is commonly used is RS-232 which only could communicate in one to one scheme. This paper will explain a software using the RS-485 interface that can communicate in one to many scheme using a multidrop network system. The server will monitor slave computer, so from the master computer we will be able to see what kind of application is being done in the slave computer. Software has been designed under Windows environtment (32 bit using Delphi 3.0 from Borland International, Inc Software. There are two kinds of software : master and slave. The master software will control the computer we want to monitor, while the slave software will send the monitor picture to the master. The system hardware uses 3 RS 232 to RS 485 converter installed at the 3 PCs, one converter is used by master, and 2 converters are used by slave computers. Testing of picture compression, picture transmission with varying transmission speed have been done in this experiment. Abstract in Bahasa Indonesia : Komunikasi serial banyak sekali digunakan dalam interface PC namun serial yang biasa dipakai adalah RS-232 yang hanya dapat berhubungan secara one to one. Dalam paper ini dibuat software menggunakan sistem RS-485 yang dapat berhubungan secara one to many menggunakan sistem multidrop network. Aplikasinya adalah monitoring komputer, jadi dalam sebuah komputer dapat melihat apa yang sedang dikerjakan oleh komputer lain dengan melihat layar monitor komputer tersebut. Software dibuat berbasis Windows (32 bit dengan bantuan Delphi 3.0 dari Borland International, Inc Software. Software terdiri dari dua yaitu master sebagai pengontrol untuk melihat komputer lain sedangkan slave sebagai pengirim gambar pada komputer yang dimonitor dan bersifat resident dan aktif. Hardware yang digunakan adalah 3 buah RS 232 to RS 485 Converter yang dipasang pada 3 buah PC dimana sebuah PC digunakan untuk master dan 2

  9. RS-34 Phoenix In-Space Propulsion System Applied to Active Debris Removal Mission

    Science.gov (United States)

    Esther, Elizabeth A.; Burnside, Christopher G.

    2014-01-01

    In-space propulsion is a high percentage of the cost when considering Active Debris Removal mission. For this reason it is desired to research if existing designs with slight modification would meet mission requirements to aid in reducing cost of the overall mission. Such a system capable of rendezvous, close proximity operations, and de-orbit of Envisat class resident space objects has been identified in the existing RS-34 Phoenix. RS-34 propulsion system is a remaining asset from the de-commissioned United States Air Force Peacekeeper program; specifically the pressure-fed storable bi-propellant Stage IV Post Boost Propulsion System. The National Aeronautics and Space Administration (NASA) Marshall Space Flight Center (MSFC) gained experience with the RS-34 propulsion system on the successful Ares I-X flight test program flown in the Ares I-X Roll control system (RoCS). The heritage hardware proved extremely robust and reliable and sparked interest for further utilization on other potential in-space applications. Subsequently, MSFC has obtained permission from the USAF to obtain all the remaining RS-34 stages for re-use opportunities. The MSFC Advanced Concepts Office (ACO) was commissioned to lead a study for evaluation of the Rocketdyne produced RS-34 propulsion system as it applies to an active debris removal design reference mission for resident space object targets including Envisat. Originally designed, the RS-34 Phoenix provided in-space six-degrees-of freedom operational maneuvering to deploy payloads at multiple orbital locations. The RS-34 Concept Study lead by sought to further understand application for a similar orbital debris design reference mission to provide propulsive capability for rendezvous, close proximity operations to support the capture phase of the mission, and deorbit of single or multiple large class resident space objects. Multiple configurations varying the degree of modification were identified to trade for dry mass optimization and

  10. Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis.

    Science.gov (United States)

    Li, Jingguang; Zhao, Yajun; Li, Rena; Broster, Lucas S; Zhou, Chenglin; Yang, Suyong

    2015-01-01

    A common variant in the oxytocin receptor gene (OXTR), rs53576, has been broadly linked to socially related personality traits and behaviors. However, the pattern of published results is inconsistent. Here, we performed a meta-analysis to comprehensively evaluate the association. The literature was searched for relevant studies and effect sizes between individuals homozygous for the G allele (GG) and individuals with A allele carriers (AA/AG). Specifically, two indices of sociality were evaluated independently: i) general sociality (24 samples, n = 4955), i.e., how an individual responds to other people in general; and ii) close relationships (15 samples, n = 5262), i.e., how an individual responds to individuals with closed connections (parent-child or romantic relationship). We found positive association between the rs53576 polymorphism and general sociality (Cohen's d = 0.11, p = .02); G allele homozygotes had higher general sociality than the A allele carriers. However, the meta-analyses did not detect significant genetic association between rs53576 and close relationships (Cohen's d = 0.01, p = .64). In conclusion, genetic variation in the rs53576 influences general sociality, which further implies that it is worthy to systematically examine whether the rs53576 is a valid genetic marker for socially related psychiatric disorders.

  11. Prediction of solubilities for ginger bioactive compounds in hot water by the COSMO-RS method

    Science.gov (United States)

    Zaimah Syed Jaapar, Syaripah; Azian Morad, Noor; Iwai, Yoshio

    2013-04-01

    The solubilities in water of four main ginger bioactives, 6-gingerol, 6-shogaol, 8-gingerol and 10-gingerol, were predicted using a conductor-like screening model for real solvent (COSMO-RS) calculations. This study was conducted since no experimental data are available for ginger bioactive solubilities in hot water. The σ-profiles of these selected molecules were calculated using Gaussian software and the solubilities were calculated using the COSMO-RS method. The solubilities of these ginger bioactives were calculated at 50 to 200 °C. In order to validate the accuracy of the COSMO-RS method, the solubilities of five hydrocarbon molecules were calculated using the COSMO-RS method and compared with the experimental data in the literature. The selected hydrocarbon molecules were 3-pentanone, 1-hexanol, benzene, 3-methylphenol and 2-hydroxy-5-methylbenzaldehyde. The calculated results of the hydrocarbon molecules are in good agreement with the data in the literature. These results confirm that the solubilities of ginger bioactives can be predicted using the COSMO-RS method. The solubilities of the ginger bioactives are lower than 0.0001 at temperatures lower than 130 °C. At 130 to 200 °C, the solubilities increase dramatically with the highest being 6-shogaol, which is 0.00037 mole fraction, and the lowest is 10-gingerol, which is 0.000039 mole fraction at 200 °C.

  12. The MIQ-RS: A Suitable Option for Examining Movement Imagery Ability

    Directory of Open Access Journals (Sweden)

    Melanie Gregg

    2010-01-01

    Full Text Available Within rehabilitation settings, mental imagery helps to promote long-term recovery and facilitates compliance to rehabilitation exercises. Individuals who are able to effectively engage in imagery practice are likely to gain the most benefit from imagery training. Thus, a suitable imagery ability measurement tool for individuals with movement limitations is needed. The purpose of the present study was to evaluate the Movement Imagery Questionnaire—Revised second version (MIQ-RS, and compare the results of this new version with Hall and Martin's (1997 MIQ-R. Three-hundred and twenty participants from a variety of sports and performance levels agreed to take part. Results showed the internal consistency and test–retest reliability of the MIQ-RS were satisfactory, the two-factor structure of the MIQ-RS was supported by confirmatory factor analysis, and Pearson correlations indicated a strong relationship between the MIQ-R and MIQ-RS. It appears the MIQ-RS is a suitable option for examining movement imagery ability primarily aimed at the upper extremity.

  13. Association of Oxytocin Receptor Gene (OXTR rs53576 Polymorphism with Sociality: A Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Jingguang Li

    Full Text Available A common variant in the oxytocin receptor gene (OXTR, rs53576, has been broadly linked to socially related personality traits and behaviors. However, the pattern of published results is inconsistent. Here, we performed a meta-analysis to comprehensively evaluate the association. The literature was searched for relevant studies and effect sizes between individuals homozygous for the G allele (GG and individuals with A allele carriers (AA/AG. Specifically, two indices of sociality were evaluated independently: i general sociality (24 samples, n = 4955, i.e., how an individual responds to other people in general; and ii close relationships (15 samples, n = 5262, i.e., how an individual responds to individuals with closed connections (parent-child or romantic relationship. We found positive association between the rs53576 polymorphism and general sociality (Cohen's d = 0.11, p = .02; G allele homozygotes had higher general sociality than the A allele carriers. However, the meta-analyses did not detect significant genetic association between rs53576 and close relationships (Cohen's d = 0.01, p = .64. In conclusion, genetic variation in the rs53576 influences general sociality, which further implies that it is worthy to systematically examine whether the rs53576 is a valid genetic marker for socially related psychiatric disorders.

  14. Relationship between single nucleotide polymorphism in Smad-interacting protein-1 gene (rs41292293 and rs34961586) and Hirschsprung's disease%SIP1单核苷酸多态性rs41292293和rs34961586与先天性巨结肠的关系

    Institute of Scientific and Technical Information of China (English)

    高红; 张娟; 吕良英; 张志波; 王维林

    2009-01-01

    Objective To investigate the relationship between single nucleotide polymorphisms (SNPs) in Smad-interacting protein-1 (SIP1) (rs41292293 and rs34961586) and Hirschsprung's dis-ease (HD). Methods The genotypes of SIP1 gene SNPs were detected in 180 patients with HD (HD group) and 180 healthy blood donors (control group). DNA was extracted with standard methods. Polymerase chain reaction (PCR) was applied to detect exon5-rs41292293 and exon6-rs4961586 of SIP1. Subsequently, the PCR products were digested with restrictive endonuclease and sequenced by the direct sequencing method. The frequencies of allele and genotypes in both groups were analyzed with Chi-square test. Results Significant difference was noted in the frequencies of the allele (A, G) and genotypes (GA, GG) in SIP1 gene rs41292293 between the HI) group and control group (P< 0. 05). Polymorphism of AG was noted in patients with HD. The genotypic frequencies of GA, AA and GG in the control group and HD group were 48. 89% vs 37. 78%, 35.00% vs 49. 44%, and 16. 11% vs 12. 78%, respectively. Allele frequencies of A (68. 33%) and G (31.67%) were related with HD (P<0.05). Frequencies of the allele (C, G) and genotypes (GC, GG) in SIP1 gene rs34961586 were related with HD. Polymorphism of CG was noted in the HD group. The genotypic frequencies of GC, GG and CC in the control group and the HD group were 34. 44% vs 46. 11%, 56. 11% vs 39. 44%, and 9. 45% vs 14. 45%, respectively. Allele frequency of G (65.83%) and C (34. 17%) was related to the HD ( P < 0. 05 ). Heterozygosity of rs41292293 was noted in the HD group as follows: CCC→CGA mu-tation at position 268 and TGG→ TGT mutation at position 256.Heterozygosity of rs34961586 was also noted in the HD group: CCA→CAC, TGC→TTC and TGC→ TGG mutation at position 135. Conclusions SIP1 rs41292293 and rs34961586 allelic variation may be closely related to the pathogenesis of HD. This study provides some primary laboratory data for fur-ther study on the

  15. Impact of CPS1 Gene rs7422339 Polymorphism in Argentine Patients With Hyperhomocysteinemia

    Directory of Open Access Journals (Sweden)

    Silene M. Silvera-Ruiz BSc

    2015-05-01

    Full Text Available Carbamoyl phosphate synthetase 1 (CPS1 is a key gene in the first step of urea cycle and has been correlated with nitric oxide level and vascular smooth muscle activity. A functional single-nucleotide polymorphism C/A at position 4217 in CPS1 (National Center for Biotechnology Information SNP database no. rs7422339, T1405N was reported to be associated with high homocysteine (Hcy plasma values. Although genetic variants of methylenetetrahydrofolate reductase (MTHFR gene are known to influence Hcy concentration, other genetic determinants of Hcy remain largely unknown. The association between the CPS1 rs7422339 and the risk of hyperhomocysteinemia in Latin American populations is unknown. Here, we study this association in 100 patients having hyperhomocysteinemia without MTHFR c.677C>T polymorphism and 100 controls. CPS1 rs7422339 was studied using polymerase chain reaction and enzymatic restriction. Comparisons of the CPS1 rs7422339 genotype distributions revealed a significant difference between groups (P = 2.3 × 10−3. Patients carrying polymorphic allele showed almost 3 times higher risk (odds ratio [OR] = 2.47 of hyperhomocysteinemia than wild-type allele, suggesting that rs7422339 SNP is associated with high Hcy levels in the Argentine population.

  16. Two-Component Signal Transduction System SaeRS Positively Regulates Staphylococcus epidermidis Glucose Metabolism

    Directory of Open Access Journals (Sweden)

    Qiang Lou

    2014-01-01

    Full Text Available Staphylococcus epidermidis, which is a causative pathogen of nosocomial infection, expresses its virulent traits such as biofilm and autolysis regulated by two-component signal transduction system SaeRS. In this study, we performed a proteomic analysis of differences in expression between the S. epidermidis 1457 wild-type and saeRS mutant to identify candidates regulated by saeRS using two-dimensional gel electrophoresis (2-DE combined with matrix-assisted laser desorption/lonization mass spectrometry (MALDI-TOF-MS. Of 55 identified proteins that significantly differed in expression between the two strains, 15 were upregulated and 40 were downregulated. The downregulated proteins included enzymes related to glycolysis and TCA cycle, suggesting that glucose is not properly utilized in S. epidermidis when saeRS was deleted. The study will be helpful for treatment of S. epidermidis infection from the viewpoint of metabolic modulation dependent on two-component signal transduction system SaeRS.

  17. Prostasin gene polymorphism at rs12597511 is associated with severe preeclampsia in Chinese Han women

    Institute of Scientific and Technical Information of China (English)

    Luo Dong; Zhang Yanyan; Bai Yi; Liu Xijing; Gong Yunhui; Zhou Bin; Zhang Lin

    2014-01-01

    Background Preeclampsia,characterized by hypertension and proteinuria,is a multifactorial disease associated with shallow invasion of trophoblast cells and inadequate spiral artery remodeling.Trophoblast and tumor cells have similar invasion mechanism.Prostasin is closely related to tumor development,invasion and metastasis and influences blood pressure through activating epithelial sodium channel.The effect of prostasin on the pathogenesis of preeclampsia remains unclear.This study investigated the association of prostasin gene at rs12597511 with severe preeclampsia.Methods A single nucleotide polymorphism,rs12597511,was tested with polymerase chain reaction and restrictionfragment length polymorphism analyses in 179 severe preeclampsia patients and 222 normal pregnant women.Results The frequencies of TC + CC genotypes were significantly higher in severe preeclampsia group compared with in control group (the adjusted odds ratio was 2.030,95% confidence interval 1.195-3.449,P=0.009).The C allele of rs12597511 was present significantly more often among women with severe preeclampsia (P=0.001).Genotyping analysis showed that the C allele of rs12597511 could confer a risk for severe preeclampsia.Conclusion The higher frequency of C allele of prostasin gene at rs12597511 is associated with severe preeclampsia.

  18. Association of the FTO rs9939609 polymorphism with obesity in Roma/Gypsy population.

    Science.gov (United States)

    Mačeková, Soňa; Bernasovský, Ivan; Gabriková, Dana; Bôžiková, Alexandra; Bernasovská, Jarmila; Boroňová, Iveta; Behulová, Regina; Svíčková, Petra; Petrejčíková, Eva; Soták, Miroslav; Sovičová, Adriana; Carnogurská, Jana

    2012-01-01

    The rs9939609 SNP located in the first intron of the fat mass and obesity associated gene (FTO) has been found to be associated with common obesity mainly in populations of European descent. The Roma/Gypsy population as an ethnic minority of Asian Indian origin is well known for its adverse health status with a high prevalence of obesity. The main aim of this study was to examine the contribution of the rs9939609 FTO polymorphism to the high prevalence of obesity in the Roma/Gypsy population. Following a number of anthropometric measurements, the FTO rs9939609 polymorphism was genotyped in 312 Roma/Gypsy individuals. We observed significant differences in body mass index (BMI), waist circumference, and waist-to-hip ratio between different genotypes (P = 0.003, P = 0.012, and P = 0.03, respectively). The waist circumference in the subjects with AA genotype was about 7.1 cm larger than in those with TT genotypes (P = 0.005). However, the strongest association of minor allele A of the rs9939609 FTO polymorphism was found with BMI (odds ratio, 1.55; 95% confidence interval, 1.129-2.128; P = 0.007), even after adjusting for age, sex, and smoking status. This study provides the first report of allele and genotype frequencies for the rs9939609 polymorphism and also the first evidence of the association of the FTO variant with obesity in the Roma/Gypsy population.

  19. Anti Pneumococcal Activity of Azithromycin-Eudragit RS100 Nano-Formulations

    Science.gov (United States)

    Adibkia, Khosro; Khorasani, Golrokh; Payab, Shahriar; Lotfipour, Farzaneh

    2016-01-01

    Purpose: Bacterial pneumonia is a common lung infection caused by different types of bacteria. Azithromycin (AZI), an azalide antibiotic, is widely used to manage pneumococcal infections. Studies have shown that antibiotics in nanocarriers may lead to increased antibacterial activity and reduced toxicity. The aim of this work was to valuate in vitro antibacterial performance azithromycin-Eudragit RS100 nano-formulations against Streptococcus pneumoniae and Staphylococcus aureus. Methods: AZI-Eudragit RS100 nanoparticles were prepared via electrospinning technique and the in vitro antibacterial performance against S. pneumoniae and S. aureus were assessed using agar dilution method. Results: Nanofibers in the sizes about 100-300 nm in diameter and micro scale in length and nanobeads in the range of 100-500 nm were achieved. The Minimum Inhibitory Concentrations (MIC) showed an enhancement in the antimicrobial effect of AZI-Eudragit RS100 nanofibers (40 µg/ml) compare to untreated AZI solution (>160 µg/ml) against S. pneumonia. The MIC value for AZI-Eudragit RS100 nanofibers against S. aureus was >128 µg/ml, same as that of the untreated AZI solution. Conclusion: The enhanced efficiency of AZI in nanofibers could be related to the more adsorption opportunity of nanofibers to S. pneumonia capsulated cell wall which provides an antibiotic depot on the bacterial surface compared to S. aureus. AZI-Eudragit RS100 nanofibers with enhanced antimicrobial effect against S. pneumonia can be considered as a candidate for in vivo evaluations in antibiotic therapy of Pneumococcal infections.

  20. Anthrax toxin receptor 2 gene (ANTXR2) rs4333130 is associated with ankylosing spondylitis.

    Science.gov (United States)

    Ou, Yanjuan

    2015-01-01

    Results of recent published studies on the association between the ANTXR2 rs4333130 polymorphism and the risk of ankylosing spondylitis (AS) have often been conflicting. To make a more precise estimation of the potential relationship, a meta-analysis was performed. We conducted a comprehensive search in the electronic database of PubMed and Embase to retrieve relevant articles. Nine studies including 14,523 cases and 34,421 controls were finally selected in this meta-analysis. ANTXR2 rs4333130 was significantly associated with a decreased risk of AS (OR=0.87; 95% CI, 0.84-0.90; P<0.00001). In the subgroup analysis by race, ANTXR2 rs4333130 was significantly associated with a decreased risk of AS in both Asian (OR=0.80; 95% CI, 0.65-0.99; P=0.04) and Caucasian (OR=0.87; 95% CI, 0.84-0.90; P<0.00001). In the subgroup analysis by HLA-B27 status, HLA-B27 positive individuals with ANTXR2 rs4333130 showed decreased AS risk (OR=0.89; 95% CI, 0.83-0.96; P=0.002). However, HLA-B27 negative individuals with this polymorphism did not showed decreased AS risk (OR=0.96; 95% CI, 0.88-1.06; P=0.44). In conclusion, this meta-analysis suggested a significant association between ANTXR2 rs4333130 polymorphism and AS risk.

  1. Study and Implementation Method of Communication and Control Technologies of Projector Based on RS232 Serial Interface%投影机RS232串口通信控制研究与实现

    Institute of Scientific and Technical Information of China (English)

    黄天强

    2013-01-01

    本文介绍了投影机RS232串口通信控制的研究与实现方法,讨论了投影机 RS232串行通信控制技术及 MSComm串行通信控件,研究利用VB语言编程实现投影机RS232串行通信控制的过程。%Having introduced the study and implementation method of Communication and control technologies of projector based on RS232 Serial Interface, the RS232 serial communication and control of projector and MSComm control technology in VB 6.0 are introduced, the use of VB 6.0 programming RS232 serial communication and control process of projector is studied.

  2. ACACβ gene (rs2268388) and AGTR1 gene (rs5186) polymorphism and the risk of nephropathy in Asian Indian patients with type 2 diabetes

    DEFF Research Database (Denmark)

    Shah, Viral N; Cheema, Balneek Singh; Sharma, Rajni;

    2013-01-01

    Patients with type 2 diabetes (T2DM) are usually obese and concurrent obesity results into activation of the renin-angiotensin-system (RAS) which is a risk factor for diabetic nephropathy (DN). Gene-gene interaction between acetyl-coenzymeA carboxylase beta (ACACβ) gene, which is involved in fatty....... We also found significant epistatic interactions between these two genes. TT genotypes of ACACβ gene and CC genotype of AGTR1 gene confers the risk of DN and both genes had significant epistatic interaction in Asian Indian patients with T2DM....... acid metabolism and angiotensin II receptors (AGTR1) gene, which mediates RAS proteins actions on renal tissue, polymorphism with DN have not been studied earlier. The present study was designed with the aim to examine the association of an ACACβ (rs2268388) and AGTR1 (rs5186) gene polymorphism...

  3. 基于C++ Builder的RS232串行通信实现%Implementation of Serail Communication on RS232 by C++ Builder

    Institute of Scientific and Technical Information of China (English)

    范伟亮; 杨景曙; 赵义正

    2008-01-01

    对Windows环境下,使用C++ Builder编译平台实现RS-232串行通信的方法进行研究,分析比较了三种方法,并例举了在导航系统可视化仿真软件的开发设计中TComm方法的应用.

  4. Comments on: Association Study between Coronary Artery Disease and rs1333049 and rs10757274 Polymorphisms at 9p21 Locus in South-West Iran

    Directory of Open Access Journals (Sweden)

    Michael H. Preuß

    2016-02-01

    Full Text Available Foroughmand et al. (1 have recently reported association between coronary artery disease (CAD and two well-known single nucleotide polymorphisms (SNPs on chromosome 9p21.3 in subjects from South-West Iran. We doubt the validity of their findings. Genotyping was done using ARMS-PCR for rs1333049 and rs10757274 in their study. When we first looked at the genotype frequencies, we observed a substantial excess of heterozygote subjects for both SNPs. Specifically, the relative excess of heterozygosity (REH (2, a measure for the strength of deviation from Hardy-Weinberg equilibrium (HWE, was approximately 137% for rs1333049 in controls (REH=2.3688, Table 1. In contrast, we did not observe any deviation from HWE in our own studies (3, 4. We additionally conducted a short literature search to identify other studies from Asia, which reported genotype frequencies in controls for rs1333049. These studies are summarized in table 1. None of these studies shows a deviation from HWE in their control groups (all P>0.05. In summary, only the recent study by Foroughmand and colleagues (1 shows a marked deviation from HWE in controls with this deviation observed for both reported SNPs. Possible reasons for deviations from HWE have been summarized, e.g., in Ziegler et al. (2. The most likely cause for such a strong deviation from HWE is genotyping errors, especially because genotyping by ARMS-PCR plus gel electrophoresis is prone to such errors. However, REH could also be caused by population specifics, which has been discussed by Namipashaki et al. (5. In any case, we (2 and others (5 recommend the investigation of HWE in population-based genetic association studies to improve quality and reliability of the research results.

  5. The RNA-binding protein HOS5 and serine/arginine-rich proteins RS40 and RS41 participate in miRNA biogenesis in Arabidopsis

    KAUST Repository

    Chen, Tao

    2015-07-30

    MicroRNAs are a class of small regulatory RNAs that are generated from primary miRNA (pri-miRNA) transcripts with a stem-loop structure. Accuracy of the processing of pri-miRNA into mature miRNA in plants can be enhanced by SERRATE (SE) and HYPONASTIC LEAVES 1 (HYL1). HYL1 activity is regulated by the FIERY2 (FRY2)/RNA polymerase II C-terminal domain phosphatase-like 1 (CPL1). Here, we discover that HIGH OSMOTIC STRESS GENE EXPRESSION 5 (HOS5) and two serine/arginine-rich splicing factors RS40 and RS41, previously shown to be involved in pre-mRNA splicing, affect the biogenesis of a subset of miRNA. These proteins are required for correct miRNA strand selection and the maintenance of miRNA levels. FRY2 dephosphorylates HOS5 whose phosphorylation status affects its subnuclear localization. HOS5 and the RS proteins bind both intronless and intron-containing pri-miRNAs. Importantly, all of these splicing-related factors directly interact with both HYL1 and SE in nuclear splicing speckles. Our results indicate that these splicing factors are directly involved in the biogenesis of a group of miRNA.

  6. The RNA-binding protein HOS5 and serine/arginine-rich proteins RS40 and RS41 participate in miRNA biogenesis in Arabidopsis.

    Science.gov (United States)

    Chen, Tao; Cui, Peng; Xiong, Liming

    2015-09-30

    MicroRNAs are a class of small regulatory RNAs that are generated from primary miRNA (pri-miRNA) transcripts with a stem-loop structure. Accuracy of the processing of pri-miRNA into mature miRNA in plants can be enhanced by SERRATE (SE) and HYPONASTIC LEAVES 1 (HYL1). HYL1 activity is regulated by the FIERY2 (FRY2)/RNA polymerase II C-terminal domain phosphatase-like 1 (CPL1). Here, we discover that HIGH OSMOTIC STRESS GENE EXPRESSION 5 (HOS5) and two serine/arginine-rich splicing factors RS40 and RS41, previously shown to be involved in pre-mRNA splicing, affect the biogenesis of a subset of miRNA. These proteins are required for correct miRNA strand selection and the maintenance of miRNA levels. FRY2 dephosphorylates HOS5 whose phosphorylation status affects its subnuclear localization. HOS5 and the RS proteins bind both intronless and intron-containing pri-miRNAs. Importantly, all of these splicing-related factors directly interact with both HYL1 and SE in nuclear splicing speckles. Our results indicate that these splicing factors are directly involved in the biogenesis of a group of miRNA.

  7. Polymorphism of MDM2 promoter 309 (rs 2279744) and the risk of PCOS.

    Science.gov (United States)

    Chan, Ying; Jiang, Hongguo; Yang, Xiaoling; Li, Dongya; Ma, Lan; Luo, Ying; Tang, Wenru

    2016-01-01

    This study aimed at evaluating possible association between MDM2 SNP309 polymorphism (rs 2279744) and polycystic ovary syndrome (PCOS). One hundred and twenty-five women with PCOS and two hundred and fifty women without PCOS were collected from the department of reproductive medicine of college hospital in this case-control study. Peripheral blood samples were collected from all participants and DNA was extracted, MDM2 SNP309 polymorphism (rs 2279744) was determined from the 125 cases and 250 controls. Women were grouped into PCOS (n = 125) group and control group (n = 250). Odds ratios (OR) and 95% confidence intervals (CI) were used to evaluate the association between MDM2 SNP309 polymorphism (rs 2279744) and PCOS. The distribution of T allele was significant higher in PCOS cases than controls. MDM2 SNP 309 T allele is associated with PCOS.

  8. Genetic Algorithm to Make Persistent Security and Quality of Image in Steganography from RS Analysis

    CERN Document Server

    Nair, T R Gopalakrishnan; S, Manas

    2012-01-01

    Retention of secrecy is one of the significant features during communication activity. Steganography is one of the popular methods to achieve secret communication between sender and receiver by hiding message in any form of cover media such as an audio, video, text, images etc. Least significant bit encoding is the simplest encoding method used by many steganography programs to hide secret message in 24bit, 8bit colour images and grayscale images. Steganalysis is a method of detecting secret message hidden in a cover media using steganography. RS steganalysis is one of the most reliable steganalysis which performs statistical analysis of the pixels to successfully detect the hidden message in an image. However, existing steganography method protects the information against RS steganalysis in grey scale images. This paper presents a steganography method using genetic algorithm to protect against the RS attack in colour images. Stego image is divided into number of blocks. Subsequently, with the implementation ...

  9. rs10865331 associated with susceptibility and disease severity of ankylosing spondylitis in a Taiwanese population.

    Directory of Open Access Journals (Sweden)

    Ya-Feng Wen

    Full Text Available Ankylosing spondylitis (AS is a highly familial rheumatic disorder and is considered as a chronic inflammatory disease. Genetic factors are involved in the pathogenesis of AS. To identify genes which render people susceptible to AS in a Taiwanese population, we selected six single-nucleotide polymorphisms (SNPs from previous genome-wide association studies (GWASs which were associated with AS in European descendants and Han Chinese. To assess whether the six SNPs contributed to AS susceptibility and severity in Taiwanese population, 475 AS patients fulfilling the modified New York Criteria and 527 healthy subjects were recruited. We found that rs10865331 was significantly associated with AS susceptibility and with Bath AS Function Index (BASFI. The AA and AG genotypes of rs10865331 were also significantly associated with a higher erythrocyte sedimentation rate. Our findings provided evidence that rs10865331 is associated AS susceptibility and with disease activity (BASFI in a Taiwanese population.

  10. TERT Polymorphism rs2853669 Influences on Lung Cancer Risk in the Korean Population.

    Science.gov (United States)

    Yoo, Seung Soo; Do, Sook Kyung; Choi, Jin Eun; Lee, Shin Yup; Lee, Jaehee; Cha, Seung Ick; Kim, Chang Ho; Park, Jae Yong

    2015-10-01

    Short telomeres are known as one of the risk factors for human cancers. The present study was conducted to evaluate the association between 6 polymorphisms, which were related with short telomere length in the Korean population, and lung cancer risk using 1,100 cases and 1,096 controls. Among the 6 polymorphisms, TERT rs2853669 was significantly associated with increased lung cancer risk under a recessive model (odds ratio [OR]=1.38, 95% confidence interval [CI]=1.05-1.81, P=0.02). The effect of rs2853669 on lung cancer risk was significant in younger individuals (OR=1.73, 95% CI=1.18-2.54, P=0.005) and adenocarcinoma (OR=1.50, 95% CI=1.07-2.07, P=0.02). Our results suggest that a common functional promoter polymorphism, TERT rs2853669, may influence both telomere length and lung cancer risk in the Korean population.

  11. High-resolution optical spectroscopy of RS Ophiuchi during 2008-2009

    Science.gov (United States)

    Somero, A.; Hakala, P.; Wynn, G. A.

    2017-01-01

    RS Ophiuchi (RS Oph) is a symbiotic variable and a recurrent nova (RN). We have monitored it with the Nordic Optical Telescope and obtained 30 high-resolution (R = 46 000) optical spectra over one orbital cycle during quiescence. To our knowledge, this is the best-sampled high-resolution spectroscopic data set of RS Oph over one orbital period. We do not detect any direct signatures of an accretion disc such as double peaked emission lines, but many line profiles are complex consisting of superimposed emission and absorption components. We measure the spin of the red giant and conclude that it is tidally locked to the binary orbit. We observe Na I absorption features, probably arising from the circumbinary medium, that has been shaped by previous RN outbursts. We do not detect any intrinsic polarization in the optical wavelengths.

  12. The SaeRS Two-Component System of Staphylococcus aureus

    Science.gov (United States)

    Liu, Qian; Yeo, Won-Sik; Bae, Taeok

    2016-01-01

    In the Gram-positive pathogenic bacterium Staphylococcus aureus, the SaeRS two-component system (TCS) plays a major role in controlling the production of over 20 virulence factors including hemolysins, leukocidins, superantigens, surface proteins, and proteases. The SaeRS TCS is composed of the sensor histidine kinase SaeS, response regulator SaeR, and two auxiliary proteins SaeP and SaeQ. Since its discovery in 1994, the sae locus has been studied extensively, and its contributions to staphylococcal virulence and pathogenesis have been well documented and understood; however, the molecular mechanism by which the SaeRS TCS receives and processes cognate signals is not. In this article, therefore, we review the literature focusing on the signaling mechanism and its interaction with other global regulators. PMID:27706107

  13. P-bRS: A Physarum-Based Routing Scheme for Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Mingchuan Zhang

    2014-01-01

    Full Text Available Routing in wireless sensor networks (WSNs is an extremely challenging issue due to the features of WSNs. Inspired by the large and single-celled amoeboid organism, slime mold Physarum polycephalum, we establish a novel selecting next hop model (SNH. Based on this model, we present a novel Physarum-based routing scheme (P-bRS for WSNs to balance routing efficiency and energy equilibrium. In P-bRS, a sensor node can choose the proper next hop by using SNH which comprehensively considers the distance, energy residue, and location of the next hop. The simulation results show how P-bRS can achieve the effective trade-off between routing efficiency and energy equilibrium compared to two famous algorithms.

  14. Vascular Endothelial Growth Factor Gene Polymorphism (rs2010963 and Its Receptor, Kinase Insert Domain-Containing Receptor Gene Polymorphism (rs2071559, and Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Sebastjan Merlo

    2016-01-01

    Full Text Available Background. The current study was designed to reveal possible associations between the polymorphisms of the vascular endothelial growth factor (VEGF gene (rs2010963 and its receptor, kinase insert domain-containing receptor (KDR gene polymorphism (rs2071559, and markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM. Patients and Methods. 595 T2DM subjects and 200 control subjects were enrolled. The carotid intima-media thickness (CIMT and plaque characteristics (presence and structure were assessed ultrasonographically. Biochemical analyses were performed using standard biochemical methods. Genotyping of VEGF/KDR polymorphisms (rs2010963, rs2071559 was performed using KASPar assays. Results. Genotype distributions and allele frequencies of the VEGF/KDR polymorphisms (rs2010963, rs2071559 were not statistically significantly different between diabetic patients and controls. In our study, we demonstrated an association between the rs2071559 of KDR and either CIMT or the sum of plaque thickness in subjects with T2DM. We did not, however, demonstrate any association between the tested polymorphism of VEGF (rs2010963 and either CIMT, the sum of plaque thickness, the number of involved segments, hsCRP, the presence of carotid plaques, or the presence of unstable carotid plaques. Conclusions. In the present study, we demonstrated minor effect of the rs2071559 of KDR on markers of carotid atherosclerosis in subjects with T2DM.

  15. Method of Upgrade RS232 Device to USB Device and Development of USB Device%RS232设备到USB设备的升级及USB设备的开发

    Institute of Scientific and Technical Information of China (English)

    余善恩; 尚群立

    2007-01-01

    介绍了RS232、USB总线及其发展前景,针对USB总线技术蓬勃发展、RS232端口逐渐匮乏但RS232设备在短期内将仍有生命力这一状况,提出了一种快速升级RS232设备到USB设备的方法,同时讨论了在VB中利用MSComm控件快速开发简单USB设备这一简便途径.

  16. Integrating RS technology into a GIS-based earthquake prevention and disaster reduction system for earthquake damage evaluation

    Institute of Scientific and Technical Information of China (English)

    Li Ping; Tao Xiaxin

    2009-01-01

    This paper presents a method to integrate remote sensing (RS) data processing, generation of isoseismal lines and human-computer interaction modules into an improved GIS-based disaster reduction system. Using the RS data processing module, a statistical sample gray value and the RS-intensity at each field survey point in the region are calculated from the probabilistic relationship between the RS-variable and earthquake intensity, and stored in the G1S-based system database. Then, isoseismal lines are generated by a trend surface model from RS-intensity. They are further improved via modification of the isoseismal lines based on the empirical attenuation relationship calculated by using the RS-variable n the human-computer interaction module. The field survey shows that the proposed method gives a good generation of isoseismic lines. As a result, the accuracy of the damage and loss evaluation and the efficiency of the emergency decision making capability are improved.

  17. Association between Tourette Syndrome and the Dopamine D3 Receptor Gene Rs6280

    Institute of Scientific and Technical Information of China (English)

    Fan He; Yi Zheng; Huan-Huan Huang; Yu-Hang Cheng; Chuan-Yue Wang

    2015-01-01

    Background:Tourette syndrome (TS) is a complex,heterozygous genetic disorder.The number of molecular genetic studies have investigated several candidate genes,particularly those implicated in the dopamine system.The dopamine D3 receptor (DRD3) gene has been considered as a candidate gene in TS.There was not any report about the association study of TS and DRD3 gene in Han Chinese population.We combined a case-control genetic association analysis and nuclear pedigrees transmission disequilibrium test (TDT) analysis to investigate the association between DRD3 gene rs6280 single nucleotide polymorphisms (SNPs) and TS in a Han Chinese population.Methods:A total of 160 TS patients was diagnosed by the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition.The DRD3 gene rs6280 SNPs were genotyped by TaqMan SNP genotyping assay technique in all subjects.We used a case-control genetic association analysis to compare the difference in genotype and allele frequencies between 160 TS patients and 90 healthy controls.At the same time,we used TDT analysis to identify the DRD3 gene rs6280 transmission disequilibrium among 10l nuclear pedigrees.Results:The genotype and allele frequency of DRD3 gene rs6280 SNPs had no statistical difference between control group (90) and TS group (160) (x2 =3.647,P =0.161; x2 =0.643,P =0.423) using Chi-squared test.At the basis of the 101 nuclear pedigrees,TDT analysis showed no transmission disequilibrium ofDRD3 gene rs6280 SNPs (x2 =0; P =1).Conclusions:Our findings provide no evidence for an association between DRD3 gene rs6280 and TS in the Han Chinese population.

  18. New and Redesigned pRS Plasmid Shuttle Vectors for Genetic Manipulation of Saccharomycescerevisiae.

    Science.gov (United States)

    Chee, Mark K; Haase, Steven B

    2012-05-01

    We have constructed a set of 42 plasmid shuttle vectors based on the widely used pRS series for use in the budding yeast Saccharomyces cerevisiae and the bacterium Escherichia coli. This set of pRSII plasmids includes new shuttle vectors that can be used with histidine and adenine auxotrophic laboratory yeast strains carrying mutations in the genes HIS2 and ADE1, respectively. Our pRSII plasmids also include updated versions of commonly used pRS plasmids from which common restriction sites that occur within their yeast-selectable biosynthetic marker genes have been removed to increase the availability of unique restriction sites within their polylinker regions. Hence, our pRSII plasmids are a complete set of integrating, centromere and 2μ episomal plasmids with the biosynthetic marker genes ADE2, HIS3, TRP1, LEU2, URA3, HIS2, and ADE1 and a standardized selection of at least 16 unique restriction sites in their polylinkers. Additionally, we have expanded the range of drug selection options that can be used for PCR-mediated homologous replacement using pRS plasmid templates by replacing the G418-resistance kanMX4 cassette of pRS400 with MX4 cassettes encoding resistance to phleomycin, hygromycin B, nourseothricin, and bialaphos. Finally, in the process of generating the new plasmids, we have determined several errors in existing publicly available sequences for several commonly used yeast plasmids. Using our updated sequences, we constructed pRS plasmid backbones with a unique restriction site for inserting new markers to facilitate future expansion of the pRS series.

  19. SHBG gene polymorphism (rs1799941 associates with metabolic syndrome in children and adolescents.

    Directory of Open Access Journals (Sweden)

    Marquitta J White

    Full Text Available Metabolic syndrome (MetS is a complex disorder characterized by coexistence of several cardiometabolic (CM factors, i.e. hyperlipidemia, obesity, high blood pressure and insulin resistance. The presence of MetS is strongly associated with increased risk of cardiovascular disease (CVD. The syndrome was originally defined as an adult disorder, but MetS has become increasingly recognized in children and adolescents.Genetic variants influence biological components common to the CM factors that comprise MetS. We investigated single locus associations between six single nucleotide polymorphisms (SNPs, previously shown to modulate lipid or sex hormone binding globulin (SHBG levels, with MetS in a Turkish pediatric cohort (37 cases, 323 controls.Logistic regression analysis revealed a significant association between rs1799941, located in SHBG, and MetS (OR = 3.09, p-value = 0.006. The association with MetS remained after sequential adjustment for each CM factor included in the syndrome definition, indicating that the identified association is not being driven by any single trait. A relationship between rs1799941 and SHBG levels, was also discovered, but it was dependent on MetS status. In control subjects, the A allele of rs1799941 associated with a significant increase in SHBG levels (p = 0.012, while in cases there was no association between rs1799941 and SHBG levels (p = 0.963.The significant association between rs1799941 and MetS in children is not contingent on any single CM trait. Additionally, the presence of MetS may abrogate effect of rs1799941 polymorphism on SHBG levels in children.

  20. Is the COL5A1 rs12722 gene polymorphism associated with running economy?

    Directory of Open Access Journals (Sweden)

    Rômulo Bertuzzi

    Full Text Available The COL5A1 rs12722 polymorphism is considered to be a novel genetic marker for endurance running performance. It has been postulated that COL5A1 rs12722 may influence the elasticity of tendons and the energetic cost of running. To date, there are no experimental data in the literature supporting the relationship between range of motion, running economy, and the COL5A1 rs12722 gene polymorphism. Therefore, the main purpose of the current study was to analyze the influence of the COL5A1rs12722 polymorphism on running economy and range of motion. One hundred and fifty (n = 150 physically active young men performed the following tests: a a maximal incremental treadmill test, b two constant-speed running tests (10 km · h(-1 and 12 km · h(-1 to determine the running economy, and c a sit-and-reach test to determine the range of motion. All of the subjects were genotyped for the COL5A1 rs12722 single-nucleotide polymorphism. The genotype frequencies were TT = 27.9%, CT = 55.8%, and CC = 16.3%. There were no significant differences between COL5A1 genotypes for running economy measured at 10 km · h(-1 (p = 0.232 and 12 km · h(-1 (p = 0.259. Similarly, there were no significant differences between COL5A1 genotypes for range of motion (p = 0.337. These findings suggest that the previous relationship reported between COL5A1 rs12722 genotypes and running endurance performance might not be mediated by the energetic cost of running.

  1. Propagation of ELF Radiation from RS-LC System and Red Sprites in Earth-Ionosphere Waveguide

    Directory of Open Access Journals (Sweden)

    M. K. Paras

    2012-10-01

    Full Text Available In this paper, two different mechanisms return stroke-lateral corona (RS-LC system and red sprites which excite Earth-ionosphere waveguide have been discussed. The electric and magnetic fields from RS-LC system and red spites in the Earth-ionosphere waveguide have been calculated. It has been found that red sprites contribute to the Schumann resonances (SR greatly as compared to the RS-LC system.

  2. Adaptive efficient video transmission over the Internet based on congestion control and RS coding

    Institute of Scientific and Technical Information of China (English)

    黄伟红; 张福炎; 孙正兴

    2002-01-01

    An approach based on adaptive congestion control and adaptive error recovery with RS (Reed-Solomon) coding method is presented for efficient video transmission over the Internet.Featured by weighted moving average rate control and TCP-fdendliness,AVSP,a novel adaptive video streaming protocol,is designed with adjustable rate control parameters so as to respond quickly to the QoS status fluctuation during video transmission over the Internet.Combined with congestion control policy,an adaptive RS coding error recovery scheme with variable parameters is presented to enhance the robustness of MPEG video transmission over the Intemet with restriction to the total system bandwidth.``

  3. OpenRS-Cloud:A remote sensing image processing platform based on cloud computing environment

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    This paper explores the use of cloud computing for remote sensing image processing.The main contribution of our work is to develop a remote sensing image processing platform based on cloud computing technology(OpenRS-Cloud).This paper focuses on enabling methodical investigations into the development pattern,computational model,data management and service model exploring this novel distributed computing model.The experimental INSAR processing flow is implemented to verify the efficiency and feasibility of OpenRS-Cloud platform.The results show that cloud computing is well suited for computationally-intensive and data-intensive remote sensing services.

  4. An Integrated GIS/RS Approach for Soil Erosion Assessment and Modeling in Syrian Coastal Soils

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    An integrated remote sensing (RS) and geographic information system (GIS) technique was employed to characterize the spatial distribution of the risk of soil erosion by water on Latakia district,Syria.The universal soil loss equation (USLE) was used to calculate the annual soil loss rates for Latakia soils.Mainly,remote sensing data,soil survey,land use inventory,elevation data and climatic atlases are used as resource data sets to generate USLE factor values.The results revealed that integration of GIS/RS with USLE was a practical and effective approach for monitoring soil erosion over large areas.

  5. OPTO控制系统RS232通信的实现

    Institute of Scientific and Technical Information of China (English)

    贾坤鹏; 郑鹏

    2016-01-01

    本文通过在评价装置中应用美国OPTO 22公司的SNAP PAC控制系统,以RS232串口通讯协议实现对流量泵的精确控制,重点研究了SNAP PAC控制系统的RS232串口通讯的实现方法.该方法简单,长时间运行可靠,满足评价装置的要求.

  6. Performance Comparison of Latency for RSC-RSC and RS-RSC Concatenated Codes

    Directory of Open Access Journals (Sweden)

    Manish Kumar

    2013-09-01

    Full Text Available In this paper, we compare the latency of serially concatenated convolutional codes. In particular, we compare RSC-RSC   concatenated codes using non-iterative concatenated Viterbi decoding to RS-RSC concatenated codes using concatenation of Viterbi & Berklelamp-Massey decoding. We have also used puncturing to obtain different code rates & analyzed the effect of code rate on latency. On the basis of simulations, it is shown that RSC-RSC code is better than RS-RSC codes for low latency applications. It is also shown that a trade-off is needed between BER & latency for concatenated codes.

  7. Microchip选择RS Components作为产品样本供应商

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    全球知名微控制器半导体供货商Microchip与RS展开合作,向在www.microchip.com网站上索取样本的客户优先推荐RS产品。当欧洲和亚洲的电子设计工程师希望购买其产品时,Microchip会为顾客提供快速通道。直接链接到RS Components网站www.rs-components.com下订单。

  8. Developing RESTful services with JAX-RS 2.0, WebSockets, and JSON

    CERN Document Server

    Kalali, Masoud

    2013-01-01

    Written as an easy and practical guide, this book is a crash course on using JAX-RS 2.0, JSON, and WebSockets to develop RESTful services.Getting Started with Developing RESTful Web Services using JAX-RS 2.0, JSON, and WebSockets is a perfect reading source for application developers who are familiar with Java EE and are keen to understand the new HTML5-related functionality introduced in Java EE 7 to improve productivity. To take full advantage of this book, you need to be familiar with Java EE and have some basic understanding of using the GlassFish application server.

  9. Optimization of Operational Route in AS/RS Based on Particle Swarm Algorithm

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Optimization of the operational route in the automated storage/retrieval system (AS/RS) is transformed into the traveling salesman problem. To make the moving distance of the storage/retrieval machine shortest, we carry out a group of tests where 20 goods locations are chosed. Using PSO for operational route of AS/RS, the operation time can be shortened by about 11%. The experiments indicate that under the same conditions, the more the goods locations are, the higher the operation efficiency of the storage/retrieval machine is.

  10. Prostate Cancer Susceptibility Polymorphism rs2660753 Is Not Associated with Invasive Ovarian Cancer

    DEFF Research Database (Denmark)

    Amankwah, Ernest K; Kelemen, Linda E; Wang, Qinggang;

    2011-01-01

    BACKGROUND: We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI=1.0-1.4, P(trend) = 0.01) that showed a stronger association with the serous histological subtype (OR = 1.3, 95% CI = 1.......0-1.2, P(trend) = 0.11). There was no evidence for statistical heterogeneity in ORs across the studies. CONCLUSIONS: Although rs2660753 is a strong prostate cancer susceptibility polymorphism, the association with another hormonally related cancer, invasive EOC, is not supported by this replication study...

  11. Association Between hTERT rs2736100 Polymorphism and Sensitivity to Anti-cancer Agents

    Directory of Open Access Journals (Sweden)

    Julie eKim

    2013-08-01

    Full Text Available Background: The rs2736100 single nucleotide polymorphism (SNP is located in the intron 2 of human telomerase reverse transcriptase (hTERT gene. Recent genome-wide association studies (GWAS have consistently supported the strong association between this SNP and risk for multiple cancers. Given the important role of the hTERT gene and this SNP in cancer biology, we hypothesize that rs2736100 may also confer susceptibility to anti-cancer drug sensitivity. In this study we aim to investigate the correlation between the rs2736100 genotype and the responsiveness to anti-cancer agents in the NCI-60 cancer cell panel. Methods and Materials: The hTERT rs2736100 was genotyped in the NCI-60 cancer cell lines. The relative telomere length of each cell line was quantified using real-time PCR. The genotype was then correlated with publically available drug sensitivity data of two agents with telomerase-inhibition activity: Geldanamycin (HSP90 inhibitor and RHPS4/BRACO19 (G-quadruplex stabilizer as well as additional 110 commonly used agents with established mechanism of action. The association between rs2736100 and mutation status of TP53 gene was also tested.Results: The C allele of the SNP was significantly correlated with increased sensitivity to RHPS4/BRACO19 with an additive effect (r=-0.35, p=0.009 but not with Geldanamycin. The same allele was also significantly associated with sensitivity to antimitotic agents compared to other agents (p=0.003. The highest correlation was observed between the SNP and paclitaxel (r=-0.36, p=0.005. The telomere length was neither associated with rs2736100 nor with sensitivity to anti-cancer agents. The C allele of rs2736100 was significantly associated with increased mutation rate in TP53 gene (p=0.004.Conclusion: Our data suggested that the cancer risk allele of hTERT rs2736100 polymorphism may also affect the cancer cell response to both TERT inhibitor and anti-mitotic agents, which might be attributed to the elevated

  12. MOA-2010-BLG-523: 'FAILED PLANET' = RS CVn STAR

    Energy Technology Data Exchange (ETDEWEB)

    Gould, A.; Yee, J. C.; Pinsonneault, M. H.; Dong, Subo; Gaudi, B. S.; Hung, L.-W. [Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Bond, I. A. [Institute for Information and Mathematical Sciences, Massey University, Private Bag 102-904, Auckland 1330 (New Zealand); Udalski, A. [Warsaw University Observatory, Al. Ujazdowskie 4, 00-478 Warszawa (Poland); Han, C. [Department of Physics, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Jorgensen, U. G. [Niels Bohr Institutet, Kobenhavns Universitet, Juliane Maries Vej 30, DK-2100 Copenhagen (Denmark); Greenhill, J. [University of Tasmania, School of Mathematics and Physics, Private Bag 37, Hobart, TAS 7001 (Australia); Tsapras, Y. [Las Cumbres Observatory Global Telescope Network, 6740B Cortona Dr, Goleta, CA 93117 (United States); Bensby, T. [Lund Observatory, Department of Astronomy and Theoretical Physics, Box 43, SE-221 00 Lund (Sweden); Allen, W. [Vintage Lane Observatory, Blenheim (New Zealand); Almeida, L. A.; Jablonski, F. [Divisao de Astrofisica, Instituto Nacional de Pesquisas Espaciais, Avenida dos Astronautas, 1758 Sao Jose dos Campos, 12227-010 SP (Brazil); Bos, M. [Molehill Astronomical Observatory, North Shore (New Zealand); Christie, G. W. [Auckland Observatory, Auckland (New Zealand); DePoy, D. L. [Department of Physics and Astronomy, Texas A and M University, College Station, TX 77843-4242 (United States); Lee, C.-U. [Korea Astronomy and Space Science Institute, 776 Daedukdae-ro, Yuseong-gu, Daejeon 305-348 (Korea, Republic of); Collaboration: muFUN Collaboration; MOA Collaboration; OGLE Collaboration; MiNDSTEp Consortium; RoboNet Collaboration; PLANET Collaboration; and others

    2013-02-15

    The Galactic bulge source MOA-2010-BLG-523S exhibited short-term deviations from a standard microlensing light curve near the peak of an A {sub max} {approx} 265 high-magnification microlensing event. The deviations originally seemed consistent with expectations for a planetary companion to the principal lens. We combine long-term photometric monitoring with a previously published high-resolution spectrum taken near peak to demonstrate that this is an RS CVn variable, so that planetary microlensing is not required to explain the light-curve deviations. This is the first spectroscopically confirmed RS CVn star discovered in the Galactic bulge.

  13. Experimental research and comparison of LDPC and RS channel coding in ultraviolet communication systems.

    Science.gov (United States)

    Wu, Menglong; Han, Dahai; Zhang, Xiang; Zhang, Feng; Zhang, Min; Yue, Guangxin

    2014-03-10

    We have implemented a modified Low-Density Parity-Check (LDPC) codec algorithm in ultraviolet (UV) communication system. Simulations are conducted with measured parameters to evaluate the LDPC-based UV system performance. Moreover, LDPC (960, 480) and RS (18, 10) are implemented and experimented via a non-line-of-sight (NLOS) UV test bed. The experimental results are in agreement with the simulation and suggest that based on the given power and 10(-3)bit error rate (BER), in comparison with an uncoded system, average communication distance increases 32% with RS code, while 78% with LDPC code.

  14. Survey of 800+ datasets from human tissue and body fluid reveals XenomiRs are likely artifacts

    DEFF Research Database (Denmark)

    Kang, Wenjing; Bang-Berthelsen, Claus Heiner; Holm, Anja;

    2017-01-01

    -study in the field, surveying the presence and abundances of cross-species miRNAs (xenomiRs) in 824 sequencing datasets from various human tissues and body fluids. We find that xenomiRs are commonly present in tissues (17%) and body fluids (69%), however the abundances are low, comprising 0.001% of host human mi......RNA counts. Further, we do not detect a significant enrichment of xenomiRs in sequencing data originating from tissues and body fluids that are exposed to dietary intake (such as liver). Likewise, there is no significant depletion of xenomiRs in tissues and body fluids that are relatively separated from...

  15. Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations

    Science.gov (United States)

    Rao, Shuquan; Yao, Yao; Ryan, Joanne; Jin, Chunhui; Xu, Yong; Huang, Xinhe; Guo, Jianxiu; Wen, Yueqiang; Mao, Canquan; Meyre, David; Zhang, Fuquan

    2017-01-01

    Rs1344706 in the the zinc finger protein 804A (ZNF804A) gene has been identified to be associated with schizophrenia and bipolar disorder (BD) in Europeans. However, whether rs1344706 is associated with schizophrenia in Chinese populations remains inconclusive; furthermore, the association between rs1344706 and BD in Chinese populations has been rarely explored. To explore the association between rs1344706 and schizophrenia/BD in Chinese populations, we genotyped rs1344706 among 1128 Chinese subjects (537 patients with BD and 591 controls) and found that rs1344706 showed marginal allelic association with BD (P = 0.028) with T-allele being more prevalent in cases than that in controls (OR = 1.19, 95% CI 1.03–1.37). Meta-analysis of rs1344706 by pooling all available data showed that rs1344706 was significantly associated with BD (P = 0.001). Besides, positive association of rs1344706 with schizophrenia was observed in Northern Chinese (P = 0.005). Furthermore, ZNF804A is highly expressed in human and mouse brains, especially in prenatal stage. PMID:28120939

  16. Single-nucleotide polymorphism rs7251246 in ITPKC is associated with susceptibility and coronary artery lesions in Kawasaki disease.

    Directory of Open Access Journals (Sweden)

    Ho-Chang Kuo

    Full Text Available Kawasaki disease (KD is a multi-systemic vasculitis that preferentially affects children. A single nucleotide polymorphism (SNP in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC has been identified to be an important polymorphism in the risk of KD. This study was conducted to comprehensively investigate the associations between all tagging SNPs of ITPKC in the risk of KD in a Taiwanese population. A total of 950 subjects (381 KD patients and 569 controls were recruited. Seven tagging SNPs (rs11673492, rs7257602, rs7251246, rs890934, rs10420685, rs2607420, rs2290692 were selected for TaqMan allelic discrimination assay. Clinical data of coronary artery lesions (CAL and aneurysms were collected for analysis. A significant association was found between rs7251246 in ITPKC and CAL formation. Haplotype analysis for ITPKC polymorphisms also confirmed this association in the patients with CAL and aneurysm formation. This is the first study to identify that SNP rs7251246 in ITPKC is associated with the severity of KD.

  17. PCSK1 rs6232 Is Associated with Childhood and Adult Class III Obesity in the Mexican Population

    Science.gov (United States)

    Villalobos-Comparán, Marisela; Villamil-Ramírez, Hugo; Villarreal-Molina, Teresa; Larrieta-Carrasco, Elena; León-Mimila, Paola; Romero-Hidalgo, Sandra; Jacobo-Albavera, Leonor; Liceaga-Fuentes, Adriana E.; Campos-Pérez, Francisco J.; López-Contreras, Blanca E.; Tusié-Luna, Teresa; del Río-Navarro, Blanca E.; Aguilar-Salinas, Carlos A.; Canizales-Quinteros, Samuel

    2012-01-01

    Background Common variants rs6232 and rs6235 in the PCSK1 gene have been associated with obesity in European populations. We aimed to evaluate the contribution of these variants to obesity and related traits in Mexican children and adults. Methodology/Principal Findings Rs6232 and rs6235 were genotyped in 2382 individuals, 1206 children and 1176 adults. Minor allele frequencies were 0.78% for rs6232 and 19.99% for rs6235. Rs6232 was significantly associated with childhood obesity and adult class III obesity (OR = 3.01 95%CI 1.64–5.53; P = 4×10−4 in the combined analysis). In addition, this SNP was significantly associated with lower fasting glucose levels (P = 0.01) and with increased insulin levels and HOMA-B (P = 0.05 and 0.01, respectively) only in non-obese children. In contrast, rs6235 showed no significant association with obesity or with glucose homeostasis parameters in any group. Conclusion/Significance Although rs6232 is rare in the Mexican population, it should be considered as an important risk factor for extreme forms of obesity. PMID:22737226

  18. No evidence that GATA3 rs570613 SNP modifies breast cancer risk.

    NARCIS (Netherlands)

    Johnatty, S.E.; Couch, F.J.; Fredericksen, Z.; Tarrell, R.; Spurdle, A.B.; Beesley, J.; Chen, X.; Gschwantler-Kaulich, D.; Singer, C.F.; Fuerhauser, C.; Fink-Retter, A.; Domchek, S.M.; Nathanson, K.L.; Pankratz, V.S.; Lindor, N.; Godwin, A.K.; Caligo, M.A.; Hopper, J.; Southey, M.C.; Giles, G.G.; Justenhoven, C.; Brauch, H.; Hamann, U.; Ko, Y.D.; Heikkinen, T.; Aaltonen, K.; Aittomaki, K.; Blomqvist, C.; Nevanlinna, H.; Hall, P.; Czene, K.; Liu, J.; Peock, S.; Cook, M.; Platte, R.; Evans, D.G.; Lalloo, F.; Eeles, R.; Pichert, G.; Eccles, D.; Davidson, R.; Cole, T.; Cook, J.; Douglas, F.; Chu, C.; Hodgson, S.; Paterson, J.; Hogervorst, F.B.L.; Rookus, M.A.; Seynaeve, C.; Wijnen, J.; Vreeswijk, M.; Ligtenberg, M.J.L.; Luijt, R.B. van der; Os, T.A. van; Gille, H.J.; Blok, M.J.; Issacs, C.; Humphreys, M.K.; McGuffog, L.; Healey, S.; Sinilnikova, O.M.; Antoniou, A.C.; Easton, D.F.; Chenevix-Trench, G.

    2009-01-01

    GATA-binding protein 3 (GATA3) is a transcription factor that is crucial to mammary gland morphogenesis and differentiation of progenitor cells, and has been suggested to have a tumor suppressor function. The rs570613 single nucleotide polymorphism (SNP) in intron 4 of GATA3 was previously found to

  19. Design og samarbejde på tværs af kulturer

    DEFF Research Database (Denmark)

    Eriksen, Kaare Riise

    2005-01-01

    Artiklen beskriver erfaringerne fra en studietur og workshop med designstuderende fra aalborg universitet, Aalborg og Tsinghua University, Beijing, herunder refleksioner over forskelle i studerendes faglige styrker samt de praktiske problemer og muligheder for samarbejde på tværs af sproglige og ...

  20. The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing

    DEFF Research Database (Denmark)

    Pharoah, Paul D P; Palmieri, Rachel T; Ramus, Susan J

    2011-01-01

    PURPOSE: An assay for the single nucleotide polymorphism (SNP) rs61764370 has recently been commercially marketed as a clinical test to aid ovarian cancer risk evaluation in women with family histories of the disease. rs67164370 is in a 3'UTR miRNA binding site of the KRAS oncogene, and is a cand......PURPOSE: An assay for the single nucleotide polymorphism (SNP) rs61764370 has recently been commercially marketed as a clinical test to aid ovarian cancer risk evaluation in women with family histories of the disease. rs67164370 is in a 3'UTR miRNA binding site of the KRAS oncogene...... studies with all-cause mortality data.RESULTS: No evidence of association was observed between genotype and risk of unselected EOC (odds ratio (OR)=1.02, 95% confidence interval (CI)=0.95-1.10), serous EOC (OR=1.08, 95%CI=0.98-1.18), familial EOC (OR=1.09, 95%CI=0.78-1.54), or among women carrying...

  1. No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

    DEFF Research Database (Denmark)

    Hollestelle, Antoinette; van der Baan, Frederieke H; Berchuck, Andrew

    2015-01-01

    particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. METHODS: Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15...

  2. Cosmological constant problem in a scenario with compactifications (RS-I model)

    CERN Document Server

    Martinez-Robles, C

    2016-01-01

    In this letter, we apply the Randall-Sundrum (RS) model, a scenario based on compactifications, to control the UV divergence of the zero-point energy density equation for the vacuum fluctuations, which has been unsuccessfully addressed to the cosmological constant (CC) due to a heavy discrepancy between theory and observation. Historically, the problem of CC has been shelved in the RS point of view, having few or non literature on the subject. In this sense and as done with the hierarchy problem, we apply the RS model to solve this difference via extra dimensions; we also describe how brane effects could be the solution to this substantial difference. It should be noticed that this problem is studied assuming first Minkoswki type branes, and then followed by cosmologically more realistic FLRW type branes. We finally find some remarkably interesting consequences in the RS scenario: The CC problem can be solved via compactification of the extra dimension and the compactification radius turns out to be approxima...

  3. Design and realization of RS application system for earthquake emergency based on digital earth

    Science.gov (United States)

    Yuan, Xiaoxiang; Wang, Xiaoqing; Guo, Jianxing; Dou, Aixia; Ding, Xiang

    2016-11-01

    The current RS-based earthquake emergency system is mainly based on stand-alone software which cannot meet the requirements of massive remote sensing data and parallel seismic damage information extraction after a devastating earthquake. Taking Shaanxi Province as an example, this paper explored firstly the network-based working mode of seismic damage information extraction and data management strategy for multi-user cooperative operation based on analysing work flow of the RS application to earthquake emergency. Then, using WorldWind java SDK, the RS application system for earthquake emergency based on digital earth platform was brought out in CS architecture. Finally, spatial data tables of classification and grade of seismic damage were designed and the system was developed. This system realized functions including 3D display, management of seismic RS image and GIS data obtained before and after earthquake for different user levels and cooperative extraction and publish of such seismic information as building damage, traffic damage and seismo-geological disasters caused by earthquake in real time. Some application to earthquake cases such as 2014 M s6.5 Ludian earthquake show that this system can improve the efficiency of seismic damage information interpretation and data sharing, and provide import disaster information for decision making of earthquake emergency rescue and disaster relief.

  4. Konvergens på tværs af velfærdsstaten

    DEFF Research Database (Denmark)

    Salamon, Karen Lisa; Lex, Simon Westergaard; Friberg, Torbjörn

    2016-01-01

    På tværs af velfærdsstaten: pligten til forandring via konvergens Ifølge en aktuelt dominerende politisk diskurs skal statslig velfærd og vækst fremtidssikres via løbende og konkurrencedygtige offentlige forandringsprojekter. Artiklen dokumenterer og diskuterer etnografisk, hvorledes denne velfær...

  5. Applications of RS, GPS and GIS to Forest Management in China

    Institute of Scientific and Technical Information of China (English)

    李伟林; 肖波; 李郁

    2000-01-01

    Applications of remote sensing (RS), global positioning system (GPS), geographic information system(GIS) and combination of three-S techniques in the forest management are introduced. It indicates that,with the quickly improvement of the computer technique, the three-S system will become a very important part of the forestry management system.

  6. Design of vancomycin RS-100 nanoparticles in order to increase the intestinal permeability

    Science.gov (United States)

    Loveymi, Badir Delf; Jelvehgari, Mitra; Zakeri-Milani, Parvin; Valizadeh, Hadi

    2012-01-01

    Purpose: The purpose of this work was to preparation of vancomycin (VCM) biodegradable nanoparticles to improve the intestinal permeability, using water-in-oil-in-water (W/O/W) multiple emulsion method. Methods: The vancomycin-loaded nanoparticles were created using double-emulsion solvent evaporation method. Using Eudragit RS100 as a coating material. The prepared nanoparticles were identifyed for their micromeritic and crystallographic properties, drug loading, particle size, drug release, Zeta potential, effective permeability (Peff) and oral fractional absorption. Intestinal permeability of VCM nanoparticles was figured out, in different concentrations using SPIP technique in rats. Results: Particle sizes were between 362 and 499 nm for different compositions of VCM-RS-100 nanoparticles. Entrapment efficiency expansed between 63%-94.76%. The highest entrapment efficiency 94.76% was obtained when the ratio of drug to polymer was 1:3. The in vitro release studies were accomplished in pH 7.4. The results showed that physicochemical properties were impressed by drug to polymer ratio. The FT-IR, XRPD and DSC results ruled out any chemical interaction betweenthe drug and RS-100. Effective intestinal permeability values of VCM nanoparticles in concentrations of 200, 300 and 400 μg/ml were higher than that of solutions at the same concentrations. Oral fractional absorption was achieved between 0.419-0.767. Conclusion: Our findings suggest that RS-100 nanoparticles could provide a delivery system for VCM, with enhanced intestinal permeability. PMID:24312770

  7. Design of vancomycin RS-100 nanoparticles in order to increase the intestinal permeability

    Directory of Open Access Journals (Sweden)

    Hadi Valizadeh

    2012-06-01

    Full Text Available Purpose: The purpose of this work was to preparation of vancomycin (VCM biodegradable nanoparticles to improve the intestinal permeability, using water-in-oil-in-water (W/O/W multiple emulsion method. Methods: The vancomycin-loaded nanoparticles were created using double-emulsion solvent evaporation method. Using Eudragit RS100 as a coating material. The prepared nanoparticles were identifyed for their micromeritic and crystallographic properties, drug loading, particle size, drug release, Zeta potential, effective permeability (Peff and oral fractional absorption. Intestinal permeability of VCM nanoparticles was figured out, in different concentrations using SPIP technique in rats. Results: Particle sizes were between 362 and 499 nm for different compositions of VCM-RS-100 nanoparticles. Entrapment efficiency expansed between 63%-94.76%. The highest entrapment efficiency 94.76% was obtained when the ratio of drug to polymer was 1:3. The in vitro release studies were accomplished in pH 7.4. The results showed that physicochemical properties were impressed by drug to polymer ratio. The FT-IR, XRPD and DSC results ruled out any chemical interaction betweenthe drug and RS-100. Effective intestinal permeability values of VCM nanoparticles in concentrations of 200, 300 and 400 µg/ml were higher than that of solutions at the same concentrations. Oral fractional absorption was achieved between 0.419-0.767. Conclusion: Our findings suggest that RS-100 nanoparticles could provide a delivery system for VCM, with enhanced intestinal permeability.

  8. Psychometric Properties of the Parent and Teacher ADHD Rating Scale (ADHD-RS)

    DEFF Research Database (Denmark)

    Makransky, Guido; Bilenberg, Niels

    2014-01-01

    Attention deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in childhood and adolescence. Rating the severity of psychopathology and symptom load is essential in daily clinical practice and in research. The parent and teacher ADHD-Rating Scale (ADHD-RS) includes...

  9. Exploring Strategies for Parallel Computing of RS Data Assimilation with SWAP-GA

    Directory of Open Access Journals (Sweden)

    Shamim Akhter

    2007-01-01

    Full Text Available An agro-hydrological simulation model is useful for agriculture monitoring. One issue in running such model is parameter identification, especially when the target area is large such as provincial or country level. Remote Sensing (RS provides us with useful information over large area. RS cannot observe input parameters of agro-hydrological models directly. However, a method to estimate input parameters of such model from RS using data assimilation has been proposed by Ines[1] using the SWAP (Soil, Water, Atmosphere and Plant model. Genetic Algorithm (GA was used in this optimization process. The combined model of SWAP and GA is called SWAP-GA model. When dealing with sufficiently large and complex processing with RS data, single computers time processing extends to unacceptable limits. It becomes necessary to introduce methods for using higher processing power such as distributed computing. Cluster based computing support both high performance and load balancing parallel or distributed applications. Implementing SWAP-GA in Cluster computers will remove the computational time constraint, with this hypothesis three different parallel SWAP-GA approaches are proposed in this study. Distributed population (where GA will work on distributed manner, Distributed pixel (Pixels are processed in parallel and Mixed of distributed population and pixel model called Hybrid model. The technical considerations of implementing such methodologies are visited here.

  10. Predicting pKa for proteins using COSMO-RS

    DEFF Research Database (Denmark)

    Andersson, Martin Peter; Jensen, Jan Halborg; Stipp, Susan Louise Svane

    2013-01-01

    We have used the COSMO-RS implicit solvation method to calculate the equilibrium constants, pKa, for deprotonation of the acidic residues of the ovomucoid inhibitor protein, OMTKY3. The root mean square error for comparison with experimental data is only 0.5 pH units and the maximum error 0.8 p...

  11. INTEGRATION OF STORAGE CHARACTERISTIC WITH ON-LINE SERVICE CHARACTERISTIC OF AS/RS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Directed at how to integrated storage characteristic with on-line service characteristic of AS/RS, a solution based on database design and programming method is proposed. The results show that this model is reasonable and applicable while using in some small or middle enterprises material handling system.

  12. Relationship of rs4340 and rs4343 polymorphisms of angiotensin-converting enzyme gene to atrial fibrillation%血管紧张素转换酶基因rs4340和rs4343多态性与心房颤动的相关性

    Institute of Scientific and Technical Information of China (English)

    王亚珠; 李瑛; 范晋奇; 肖培林; 凌智瑜; 殷跃辉

    2012-01-01

    Objective To investigate the relationship of rs4340 and rs4343 polymorphisms of angiotensin- converting enzyme (ACE) gene to atrial fibrillation. Methods Venous blood samples were collected from 102 patients with atrial fibrillation, visiting four hospitals of class AAA in Chongqing Region, as well as 100 hospitalized patients without history of atrial fibrillation, from which genomic DNAs were extracted and analyzed for rs4340 and rs4343 polymorphisms of ACE gene by single nucleotide polymorphism-restriction fragment length polymorphism (SNP-RFLP) method and gene sequencing. Results The genotype distribution and allele frequency of rs4340 in the patients with atrial fibrillation showed no significant difference (P > 0. 05), while those of rs4343 showed significant difference (P ≤ 0. 001), with those in patients without history of atrial fibrillation. As compared with those in the patients without history of atrial fibrillation, the frequencies of GG + AG genotypes was significantly higher than that of AA genotype in patients with atrial fibrillation (P 0. 05). However.both left and right atrial dimensions in the patients with atrial fibrillation of 11/ AA genotype were significantly smaller, while those of II/AG genotype were significantly larger, than those of other genotypes (P < 0. 001). Conclusion The rs4343 polymorphism of ACE gene was significantly related to atrial fibrillation. II/AA genotype was a protective factor, while II/AG genotype was a risk factors for onset and progress of atrial fibrillation .%目的 探讨血管紧张素转换酶(Angiotensin converting enzyme,ACE)基因rs4340和rs4343多态性与心房颤动(简称房颤)的相关性.方法 选择重庆地区4家三甲医院就诊的102例房颤患者及同期住院的无房颤病史患者100例,抽取患者静脉血,分别提取基因组DNA,采用单核苷酸多态性-限制性片段长度多态性(Single nucleotide polymorphism,restriction fragment length polymorphism,SNP-RFLP)法及基因测序检测ACE基因rs

  13. Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis

    Directory of Open Access Journals (Sweden)

    He LL

    2016-03-01

    Full Text Available Lanlan He,1,* Yong Wang2,* 1Emergency Department, Zhenjiang First People’s Hospital, Zhenjiang, People’s Republic of China; 2Department of Interventional Radiology and Vascular Surgery, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, People’s Republic of China *Both authors contributed equally to this work Purpose: Several molecular epidemiological studies have investigated the association between OPN rs11730582 C>T polymorphism and cancer risk, but the results are inconsistent. Hence, a meta-analysis was conducted to determine the association of this polymorphism with cancer risk. Materials and methods: The related articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases. Pooled odds ratios and 95% confidence intervals were calculated to evaluate the strength of the associations. A random-effects model or fixed-effects model was employed depending on the heterogeneity. Results: A total of ten case-control studies involving 2,749 cancer cases and 3,398 controls were included in the meta-analysis. In overall analysis, OPN rs11730582 C>T polymorphism was not associated with cancer risk. In a stratified analysis by cancer type, no significant association was found between OPN rs11730582 C>T polymorphism and the risk of glioma, gastric cancer, and other cancers. Conclusion: This meta-analysis suggests that OPN rs11730582 C>T polymorphism is not associated with cancer susceptibility. Keywords: osteopontin, polymorphism, cancer, risk 

  14. Optimal Storage Rack Design for a 3-dimensional Compact AS/RS

    NARCIS (Netherlands)

    T. Le-Duc (Tho); M.B.M. de Koster (René)

    2005-01-01

    textabstractIn this paper, we consider a newly-designed automated storage and retrieval system (AS/RS). The system consists of an automated crane taking care of movements in the horizontal and vertical direction. A gravity conveying mechanism takes care of the depth movement. The aim of the research

  15. Prostate Cancer Susceptibility Polymorphism rs2660753 Is Not Associated with Invasive Ovarian Cancer

    DEFF Research Database (Denmark)

    Amankwah, Ernest K; Kelemen, Linda E; Wang, Qinggang;

    2011-01-01

    BACKGROUND: We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI=1.0-1.4, P(trend) = 0.01) that showed a stronger association with the serous histological subtype (OR = 1.3, 95% CI = 1...

  16. COSMO-RS-based extractant screening for phenol extraction as model system

    NARCIS (Netherlands)

    Burghoff, B.; Goetheer, E.L.V.; Haan, A.B. de

    2008-01-01

    The focus of this investigation is the development of a fast and reliable extractant screening approach. Phenol extraction is selected as the model process. A quantum chemical conductor-like screening model for real solvents (COSMO-RS) is combined with molecular design considerations. For this purpo

  17. Mapping the mouse brain with rs-fMRI: An optimized pipeline for functional network identification.

    Science.gov (United States)

    Zerbi, Valerio; Grandjean, Joanes; Rudin, Markus; Wenderoth, Nicole

    2015-12-01

    The use of resting state fMRI (rs-fMRI) in translational research is a powerful tool to assess brain connectivity and investigate neuropathology in mouse models. However, despite encouraging initial results, the characterization of consistent and robust resting state networks in mice remains a methodological challenge. One key reason is that the quality of the measured MR signal is degraded by the presence of structural noise from non-neural sources. Notably, in the current pipeline of the Human Connectome Project, a novel approach has been introduced to clean rs-fMRI data, which involves automatic artifact component classification and data cleaning (FIX). FIX does not require any external recordings of physiology or the segmentation of CSF and white matter. In this study, we evaluated the performance of FIX for analyzing mouse rs-fMRI data. Our results showed that FIX can be easily applied to mouse datasets and detects true signals with 100% accuracy and true noise components with very high accuracy (>98%), thus reducing both within- and between-subject variability of rs-fMRI connectivity measurements. Using this improved pre-processing pipeline, maps of 23 resting state circuits in mice were identified including two networks that displayed default mode network-like topography. Hierarchical clustering grouped these neural networks into meaningful larger functional circuits. These mouse resting state networks, which are publicly available, might serve as a reference for future work using mouse models of neurological disorders.

  18. The rs3857059 variant of the SNCA gene is associated with Parkinson's disease in Mexican Mestizos.

    Science.gov (United States)

    García, S; Chavira-Hernández, G; Gallegos-Arreola, M P; Dávila-Maldonado, L; García Martínez, F; Montes Almanza, L A; Palma-Flores, C; Mondragón-Terán, P; Alcaraz Estrada, S L; López-Hernández, L B

    2016-06-01

    Among the candidate genes for Parkinson's disease (PD), SNCA has replicated association in different populations. Besides other known mutations in the SNCA gene, the rs3857059 variant has also been linked to various neurodegenerative disorders. Therefore, the aim of the present study was to search for association of this variant and sporadic PD in Mexican Mestizo patients. A case-control study was performed including 241 individuals, 106 patients, and 135 healthy controls. Genotyping was performed using real-time PCR. The rs3857059 variant demonstrated an association with PD in Mexican Mestizos (OR = 2.40, CI, 1.1 to 5.1, p = 0.02) under the recessive model. In addition, a gender effect was found for the GG genotype in females (OR = 1.31, CI, 1.01 to 1.7, p = 0.037). This is the first study to confirm an association of the rs3857059 variant with PD and also to show a gender effect. Our data contribute to the elucidation of the link between rs3857059 and susceptibility to PD observed in the Mexican Mestizo population.

  19. Face and emotion expression processing and the serotonin transporter polymorphism 5-HTTLPR/rs22531.

    Science.gov (United States)

    Hildebrandt, A; Kiy, A; Reuter, M; Sommer, W; Wilhelm, O

    2016-06-01

    Face cognition, including face identity and facial expression processing, is a crucial component of socio-emotional abilities, characterizing humans as highest developed social beings. However, for these trait domains molecular genetic studies investigating gene-behavior associations based on well-founded phenotype definitions are still rare. We examined the relationship between 5-HTTLPR/rs25531 polymorphisms - related to serotonin-reuptake - and the ability to perceive and recognize faces and emotional expressions in human faces. For this aim we conducted structural equation modeling on data from 230 young adults, obtained by using a comprehensive, multivariate task battery with maximal effort tasks. By additionally modeling fluid intelligence and immediate and delayed memory factors, we aimed to address the discriminant relationships of the 5-HTTLPR/rs25531 polymorphisms with socio-emotional abilities. We found a robust association between the 5-HTTLPR/rs25531 polymorphism and facial emotion perception. Carriers of two long (L) alleles outperformed carriers of one or two S alleles. Weaker associations were present for face identity perception and memory for emotional facial expressions. There was no association between the 5-HTTLPR/rs25531 polymorphism and non-social abilities, demonstrating discriminant validity of the relationships. We discuss the implications and possible neural mechanisms underlying these novel findings.

  20. No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

    NARCIS (Netherlands)

    Hollestelle, Antoinette; van der Baan, Frederieke H.; Berchuck, Andrew; Johnatty, Sharon E.; Aben, Katja K.; Agnarsson, Bjarni A.; Aittomaki, Kristiina; Alducci, Elisa; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Antoniou, Antonis C.; Apicella, Carmel; Arndt, Volker; Arnold, Norbert; Arun, Banu K.; Arver, Brita; Ashworth, Alan; Baglietto, Laura; Balleine, Rosemary; Bandera, Elisa V.; Barrowdale, Daniel; Bean, Yukie T.; Beckmann, Lars; Beckmann, Matthias W.; Benitez, Javier; Berger, Andreas; Berger, Raanan; Beuselinck, Benoit; Bisogna, Maria; Bjorge, Line; Blomqvist, Carl; Bogdanova, Natalia V.; Bojesen, Anders; Bojesen, Stig E.; Bolla, Manjeet K.; Bonanni, Bernardo; Brand, Judith S.; Brauch, Hiltrud; Brenner, Hermann; Brinton, Louise; Brooks-Wilson, Angela; Bruinsma, Fiona; Brunet, Joan; Bruning, Thomas; Budzilowska, Agnieszka; Bunker, Clareann H.; Burwinkel, Barbara; Butzow, Ralf; Buys, Saundra S.; Caligo, Maria A.; Campbell, Ian; Carter, Jonathan; Chang-Claude, Jenny; Chanock, Stephen J.; Claes, Kathleen B. M.; Collee, J. Margriet; Cook, Linda S.; Couch, Fergus J.; Cox, Angela; Cramer, Daniel; Cross, Simon S.; Cunningham, Julie M.; Cybulski, Cezary; Czene, Kamila; Damiola, Francesca; Dansonka-Mieszkowska, Agnieszka; Darabi, Hatef; de la Hoya, Miguel; deFazio, Anna; Dennis, Joseph; Devilee, Peter; Dicks, Ed M.; Diez, Orland; Doherty, Jennifer A.; Domchek, Susan M.; Dorfling, Cecilia M.; Dork, Thilo; Dos Santos Silva, Isabel; du Bois, Andreas; Dumont, Martine; Dunning, Alison M.; Duran, Mercedes; Easton, Douglas F.; Eccles, Diana; Edwards, Robert P.; Ehrencrona, Hans; Ejlertsen, Bent; Ekici, Arif B.; Ellis, Steve D.; Engel, Christoph; Eriksson, Mikael; Fasching, Peter A.; Feliubadalo, Lidia; Figueroa, Jonine; Flesch-Janys, Dieter; Fletcher, Olivia; Fontaine, Annette; Fortuzzi, Stefano; Fostira, Florentia; Fridley, Brooke L.; Friebel, Tara; Friedman, Eitan; Friel, Grace; Frost, Debra; Garber, Judy; Garcia-Closas, Montserrat; Gayther, Simon A.; Gentry-Maharaj, Aleksandra; Gerdes, Anne-Marie; Giles, Graham G.; Glasspool, Rosalind; Glendon, Gord; Godwin, Andrew K.; Goodman, Marc T.; G