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Sample records for 2004-5 pelotas rs

  1. Metodologia do estudo da coorte de nascimentos de 1982 a 2004-5, Pelotas, RS Metodologia de estudio de la cohorte de nacimientos de 1982 a 2004-5, Pelotas, Sur de Brasil Methodology of the Pelotas birth cohort study from 1982 to 2004-5, Southern Brazil

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    Fernando C Barros

    2008-12-01

    Full Text Available OBJETIVO: Descrever os métodos utilizados no estudo longitudinal e acompanhamento das crianças nascidas em Pelotas (RS em 1982. MÉTODOS: A coorte foi iniciada com um inquérito de saúde perinatal de todas as 6.011 crianças nascidas nas maternidades de Pelotas em 1982. As 5.914 crianças nascidas vivas foram incluídas nos estudos de acompanhamento. Até 2004-5 foram realizados oito acompanhamentos, com a aplicação de questionários às mães e/ou aos membros da coorte, conforme a faixa etária. Exames antropométricos e clínicos foram realizados nas visitas. Os participantes da coorte são descritos conforme variáveis demográficas, socioeconômicas e de saúde colhidas nos primeiros acompanhamentos, que são utilizadas como variáveis de exposição. RESULTADOS: A maior parte dos jovens da coorte foram acompanhados durante 23 anos de vida e distintas visitas. Os acompanhamentos que obtiveram maior êxito foram aqueles precedidos por um censo da cidade. Com este método foram localizados 87,2% em 1984 (idade média de 19 meses, 84,1% em 2006 (média 43 meses, e 77,4% em 2004-5 (média 23 anos. CONCLUSÕES: Estudos de coorte de nascimentos podem ser realizados com sucesso em países em desenvolvimento, e a metodologia empregada nesses estudos de ciclo vital permite estudar a influência de exposições precoces sobre a determinação das doenças da vida adulta.OBJETIVO: Describir los métodos utilizados en el estudio longitudinal y acompañamiento de los niños nacidos en Pelotas (Sur de Brasil en 1982. MÉTODOS: La cohorte fue iniciada con una investigación de salud perinatal de todos los 6.011 niños nacidos en las maternidades de Pelotas en 1982. Los 5.914 niños nacidos vivos fueron incluidos en los estudios de acompañamiento. Hasta 2004-5 fueron realizados ocho acompañamientos, con la aplicación de cuestionarios a las mamás y/o a los miembros de la cohorte conforme el rango de edad. Exámenes antropométricos y cl

  2. Maternidade e paternidade na coorte de nascimentos de 1982 a 2004-5, Pelotas, RS Maternidad y paternidad en la cohorte de nacimientos de 1982 a 2004-5, Pelotas, Sur de Brasil Maternity and paternity in the Pelotas birth cohort from 1982 to 2004-5, Southern Brazil

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    Denise P Gigante

    2008-12-01

    Full Text Available OBJETIVO: Descrever a prevalência de maternidade e paternidade em adultos jovens e sua associação com variáveis perinatais, socioeconômicas e demográficas. MÉTODOS: Os participantes foram jovens com idade média de 23 anos, acompanhados em estudo de coorte desde o seu nascimento, em 1982, em Pelotas (RS e entrevistados em 2004-5. Foram considerados elegíveis os jovens que referiram ter tido um ou mais filhos, nascidos vivos ou mortos. Dois questionários foram aplicados para coletar informações sobre saúde reprodutiva, dados socioeconômicos e demográficos. As variáveis independentes foram sexo e cor da pele, renda familiar em 1982 e 2004-5, mudança de renda, peso ao nascer do jovem e escolaridade aos 23 anos. Análises brutas e ajustadas foram realizadas por meio de regressão de Poisson para investigar os efeitos das variáveis independentes sobre a maternidade/paternidade na adolescência. RESULTADOS: De 4.297 jovens entrevistados, 1.373 (32% eram mães ou pais, dos quais 842 (19,6% haviam experimentado a maternidade/paternidade na adolescência. O planejamento da gravidez do primeiro filho mostrou relação direta com a idade do jovem. Relação inversa foi observada entre as variáveis socioeconômicas e a ocorrência de maternidade/paternidade na adolescência. A probabilidade de ser mãe na adolescência foi maior entre as mulheres pretas ou pardas, mas a cor da pele não esteve associada com a paternidade na adolescência. CONCLUSÕES: Houve forte relação entre a maternidade/paternidade na adolescência e condições socioeconômicas, a qual deve ser considerada no delineamento de ações preventivas no campo da saúde pública.OBJETIVO: Describir la prevalencia de maternidad y paternidad en adultos jóvenes y su asociación con variables perinatales, socioeconómicas y demográficas. MÉTODOS: Los participantes fueron jóvenes con edad promedio de 23 años, acompañados en estudio de cohorte desde su nacimiento, en 1982

  3. Determinantes sociais da iniciação sexual precoce na coorte de nascimentos de 1982 a 2004-5, Pelotas, RS Determinantes sociales de la iniciación sexual precoz en la cohorte de nacimientos de 1982 a 2004-5, Pelotas, Sur de Brasil Determinants of early sexual initiation in the Pelotas birth cohort from 1982 to 2004-5, Southern Brazil

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    Helen Gonçalves

    2008-12-01

    Full Text Available OBJETIVO: Analisar determinantes sociais da iniciação sexual precoce de jovens pertencentes a uma coorte de nascimentos. MÉTODOS: Foram entrevistados em 2004-5 os indivíduos da coorte de nascimentos de Pelotas (RS, em 1982 (N=4.297. A iniciação sexual precoce (OBJETIVO: Analizar las determinantes sociales de la iniciación sexual precoz de jóvenes pertenecientes a una cohorte de nacimientos. MÉTODOS: Fueron entrevistados en 2004-5 los individuos de la cohorte de nacimientos de Pelotas (Sur de Brasil, en 1982 (N= 4.297. La iniciación sexual precoz (OBJECTIVE: To analyze social determinants of early sexual initiation among young adults from a birth cohort. METHODS: Individuals from the 1982 birth cohort (N=4,297 were interviewed in 2004-5, city of Pelotas, Southern Brazil. Early sexual initiation (<13 years of age was the outcome. Descriptive and stratified analyses were performed according to sex. Variables analyzed were family income in 1982, ethnicity, young adult's level of education and change in income (between 1982 and 2004-5. Ethnographic data were used to complement result analysis. RESULTS: Prevalence of early sexual initiation was higher among black and mixed men, and those with low level of education and low family income in 1982 and 2004-5. More traditional male sexual role requirements, such as virility and sexual initiative, showed more repercussion and adherence from an early age among men. Young family women with higher income and level of education tended to delay their sexual initiation. Imposition of traditional values was found to influence early sexual initiation among men and women with lower level of education and income. CONCLUSIONS: Results found re-established the economic factor as a determinant of behavior or uses of sexuality for both sexes. To focus on political efforts that help the economically disadvantaged to have opportunities and egalitarian future perspectives is an important strategy for health

  4. Utilização de serviços de saúde por adultos da coorte de nascimentos de 1982 a 2004-5, Pelotas, RS Utilización de servicios de salud por adultos de la cohorte de nacimientos de 1982 a 2005, Pelotas, Sur de Brasil Pattern of health services utilization by adults of the Pelotas birth cohort from 1982 to 2004-5, Southern Brazil

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    Juvenal S Dias-da-Costa

    2008-12-01

    Full Text Available OBJETIVO: Descrever o padrão de utilização de serviços de saúde por adultos jovens. MÉTODOS: Estudo longitudinal em Pelotas (RS, em que os indivíduos foram localizados no seu nascimento em 1982 e acompanhados até os 23 anos. O desfecho foi definido por informações coletadas sobre consultas com profissionais de saúde realizadas no ano anterior à entrevista entre 2004 e 2005. Os locais de consulta foram categorizados como públicos, privados ou planos de saúde. Análises descritivas foram realizadas para utilização e tipo de serviço de saúde. Regressão de Poisson foi utilizada na análise ajustada. RESULTADOS: Dos entrevistados, 72,0% tiveram consulta com profissionais de saúde no ano anterior à entrevista; 86,2% (IC 95% 84,7;87,7 das mulheres e 59,3% (IC 95% 57,3;61,3 dos homens. Mesmo quando excluídas as consultas com ginecologista, as mulheres continuavam tendo mais consultas do que os homens, 68,4% (IC 95% 66,4;70,4. A utilização dos serviços de saúde foi mais freqüente entre os entrevistados de melhor nível socioeconômico. Diferença de menor uso em relação à cor da pele não branca foi observada somente entre os jovens do sexo masculino. Houve diferenças em relação ao tipo de profissional consultado por homens e mulheres e também conforme a renda familiar. Homens e mulheres consultaram mais freqüentemente o sistema público, os serviços conveniados e em menor proporção o sistema privado. CONCLUSÕES: A situação socioeconômica influenciou a utilização e o tipo de serviço de saúde, com homens e mulheres classificados como "pobres no momento", indicando menor utilização de serviços. Tais diferenças socioeconômicas podem ser indicativas de dificuldades de acesso ao sistema de saúde.OBJETIVO: Describir el patrón de utilización de servicios de salud por adultos jóvenes. MÉTODOS: Estudio longitudinal en Pelotas (Sur de Brasil, en que los individuos fueron localizados en su nacimiento en 1982 y

  5. Methodological aspects of the 1993 Pelotas (Brazil birth cohort study Aspectos metodológicos da coorte de nascimentos de 1993 em Pelotas, RS

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    Cesar Gomes Victora

    2006-02-01

    Full Text Available This paper describes the main methodological aspects of a cohort study, with emphasis on its recent phases, which may be relevant to investigators planning to carry out similar studies. In 1993, a population based study was launched in Pelotas, Southern Brazil. All 5,249 newborns delivered in the city's hospitals were enrolled, and sub-samples were visited at the ages of one, three and six months and of one and four years. In 2004-5 it was possible to trace 87.5% of the cohort at the age of 10-12 years. Sub-studies are addressing issues related to oral health, psychological development and mental health, body composition, and ethnography. Birth cohort studies are essential for investigating the early determinants of adult disease and nutritional status, yet few such studies are available from low and middle-income countries where these determinants may differ from those documented in more developed settings.Descrever aspectos metodológicos do estudo da coorte de crianças que podem ser relevantes para pesquisadores que estejam planejando investigações semelhantes. Em 1993, uma coorte de base populacional foi recrutada em Pelotas, RS. Os 5.249 recém-nascidos nos hospitais da cidade foram acompanhados com um, três e seis meses, e com um e quatro anos de idade. Subestudos estão sendo realizados sobre saúde bucal, desenvolvimento psicológico e saúde mental, composição corporal e aspectos etnográficos. Em 2004-5 foi possível entrevistar 87,5% da coorte inicial, com a idade de 10-12 anos. Estudos de coortes de nascimentos são essenciais para investigar os determinantes precoces da morbidade e estado nutricional de adultos. No entanto, há poucos estudos com esta metodologia em países de renda média e baixa, e alguns dos determinantes da situação de saúde podem ser distintos daqueles observados em países ricos.

  6. Uma Proposta de Planejamento Turístico e sua Aplicação em Pelotas, RS

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    Fabiano Milano Fritzen

    2015-10-01

    Full Text Available Este artigo apresenta experiência planejamento turístico em Pelotas, RS, conduzida pelo Grupo Gestor (GG, seguindo ações do Programa de Regionalização do Turismo do Ministério do Turismo. Realizado o diagnóstico, os integrantes do GG Pelotas participaram da análise e tomada de decisão seguindo estratégias para a consolidação de destino, considerando-se as 13 dimensões descritas no estudo. Utilizou-se uma aproximação à pesquisa-ação, com abordagem quali-quantitativa e descritiva, para desenvolver o planejamento em questão. Houve quatro etapas de capacitação, utilizando-se a análise SWOT para sua construção. A partir do diagnóstico, realizou-se a hierarquização das variáveis através da Matriz de Densidade. Dessa forma, foram conhecidas as estratégias prioritárias ao planejamento de Pelotas como destino turístico, fornecendo a base para a construção do plano de ação, o qual não se efetivou. A experiência trouxe aspectos positivos como a articulação dos atores para o desenvolvimento do turismo local, motivando reflexões a respeito da condução das políticas nacionais de Turismo. Palavras-chave: Turismo. Política de Turismo. Planejamento Turístico. Pelotas, RS. A Proposal for Tourism Planning and Its Application in Pelotas, Brazil -  The planning was motivated by the actions of Tourism Regionalization Program (MTUR . From the diagnostic “Competitive Study Pelotas”, the members of the MG Pelotas were  mobilized to the analysis and decision making about the variables and dimensions of the study and the collaborative construction of strategies to  consolidate the destination. It was used research-action with a quali-quantitative and descriptive approach to develop this collaborative work between different local actors. It was made in four steps, through capacitating modules, and with the use of the analysis SWOT for its construction. From a local reality diagnostic about the 13 dimensions described in

  7. IMPACTOS DO TURISMO NA CIDADE DE PELOTAS/RS, SEGUNDO A COMUNIDADE LOCAL.

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    Dalila Rosa Hallal

    2013-12-01

    Full Text Available O fenômeno atual do rápido crescimento do turismo no mundo vem trazendo algumas importantes reflexões para governos, mercados, pesquisadores, ambientalistas e comunidades. Sabe-se que o turismo pode contribuir sensivelmente para o desenvolvimento sócio-econômico e cultural de amplas regiões e, ao mesmo tempo, em poucos anos, pode degradar o ambiente natural, as estruturas sociais e a herança históricocultural dos povos. Historicamente, é notável o poder das cidades de atrair visitantes. “É uma obra de arte viva e seus atores são seus habitantes. Há cores e odores. Hábitos e costumes. História e memória.” (WAINBERG, 2000, p.13. Com base nestas questões, o presente trabalho tem por objetivo analisar, a partir da comunidade local de Pelotas, as vantagens e desvantagens da atividade turística para a cidade. A coleta de dados foi realizada no município de Pelotas/RS através de entrevistas semiestruturadas com a comunidade local. Este estudo possibilitou a identificação dos principais impactos (econômicos, sociais, ambientais e culturais do turismo na cidade de Pelotas a partir da comunidade local. Os sujeitos identificaram vantagens e desvantagens da atividade turística, sendo as vantagens econômicas e as desvantagens ambientais as mais citadas nas entrevistas

  8. Prevalência e determinantes precoces dos transtornos mentais comuns na coorte de nascimentos de 1982, Pelotas, RS Prevalencia y determinantes precoces de los trastornos mentales comunes en la cohorte de nacimientos de 1982, Pelotas, Sur de Brasil Prevalence and early determinants of common mental disorders in the 1982 birth cohort, Pelotas, Southern Brazil

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    Luciana Anselmi

    2008-12-01

    Full Text Available OBJETIVO: Estimar a prevalência de transtornos mentais comuns e sua associação com fatores de risco numa coorte de adultos jovens. MÉTODOS: Estudo transversal aninhado à coorte de nascimentos de 1982 de Pelotas, RS. Em 2004-5, 4.297 indivíduos foram entrevistados em visita domiciliar. A probabilidade de transtornos mentais comuns foi estimada pelo Self-Report Questionnaire. Os fatores de risco incluíram variáveis socioeconômicas, demográficas, perinatais e ambientais. A análise foi estratificada por sexo e as razões de prevalência simples e ajustadas foram estimadas utilizando-se regressão de Poisson. RESULTADOS: A prevalência de transtornos mentais comuns na população geral foi 28,0%; 32,8% e 23,5%, respectivamente, entre mulheres e homens. Independentemente da pobreza em 1982, homens e mulheres pobres em 2004-5 apresentaram risco aproximado de 1,5 para esses transtornos (pOBJETIVO: Estimar la prevalencia de trastornos mentales comunes y su asociación con factores de riesgo en una cohorte de adultos jóvenes. MÉTODOS: Estudio transversal anidado a la cohorte de nacimientos de 1982 de Pelotas (Sur de Brasil. En 2004-5, 4.297 individuos fueron entrevistados en visita domiciliar. La probabilidad de trastornos mentales comunes fue estimada por el Self-Report Questionnaire. Los factores de riesgo incluyeron variables socioeconómicas, demográficas, perinatales y ambientales. El análisis fue estratificado por sexo y las razones de prevalencia simples y ajustadas fueron estimadas utilizándose regresión de Poisson. RESULTADOS: La prevalencia de trastornos mentales comunes en la población general fue de 28,0%; 32,8% y 23,5%, respectivamente, entre mujeres y hombres. Independientemente de la pobreza en 1982, hombres y mujeres pobres en 2004-5 presentaron riesgo aproximado de 1,5 para esos trastornos (pOBJECTIVE: To estimate the prevalence of common mental disorders and assess its association with risk factors in a cohort of young

  9. Saúde perinatal em Pelotas, RS, Brasil: fatores sociais e biológicos Perinatal health in Pelotas, Rio Grande do Sul, Brazil: social and biological factors

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    Fernando C. Barros

    1984-08-01

    Full Text Available Todos os nascimentos ocorridos em hospitais na cidade de Pelotas, RS, Brasil, durante 1982, foram estudados através de entrevistas hospitalares e de visitas domiciliares de uma amostra dos recém-nascidos e revisão mensal de atestados de óbito. A mortalidade perinatal para recém-nascidos de partos únicos foi de 31,9/1.000 nascidos totais, sendo a mortalidade fetal de 16,2/1.000 e a mortalidade neonatal precoce de 15,9/1.000. A incidência de baixo peso ao nascer (peso abaixo de 2.500g foi de 8,1% para partos únicos.All hospital births occurring during 1982 in Pelotas, Southern Brazil (pop. 260,000 were studied. This a highly representative perinatal population, since in this city less than 1% of the deliveries occur at home. The study was performed through: hospital interviews with mothers and evaluation of the newborn; home visits of a random sample of 15% of the births after the seventh day of life; and monthly checking of birth and death certificates. Overall, the perinatal mortality rate (PNMR for singletons was 31.9/1,000 births, fetal mortality rate (FMR being 16.2/1,000 and early neonatal mortality rate (ENMR 15.9/1,000. The incidence of low birth weight (LBW babies was 8.1%. Main causes of death were immaturity, anoxia and hyaline membrane disease. In 40% of the deaths the actual cause was not clarified. Social factors were strongly associated with perinatal health indicators. Babies whose families earned up to 1 minimum wage per month presented a PNMR of 44.0/1,000 and LBW in 12.6% of the cases, whereas those newborns of high income families (more than 10 minimum wages/month showed a PNMR of 13.2/1,000 and 4.2% of LBW. The association of perinatal performance with maternal age and provenience, birth order and smoking was also studied. When a comparison was made between the perinatal outcome of Pelotas babies with that of a highly developed country (Sweden, using standardization techniques, it was seen that although our birth

  10. Frequency of geohelminths in public squares in Pelotas, RS, Brazil Frequência de geohelmintos em praças públicas de Pelotas, RS, Brasil

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    Micaele Quintana de Moura

    2013-03-01

    Full Text Available The frequency of parasitic contamination of public areas in the municipality of Pelotas, state of Rio Grande do Sul, Brazil, was studied between June 2010 and May 2011, when soil samples were collected from eight city squares. Out of 400 samples submitted to centrifugal floatation technique in solution of sodium dichromate with density of 1.35, 176 (44% proved positive for at least one parasite; 29 (16.5% samples were multi-infested. The results showed that there was a significant soil contamination rate in all the parks included in the study. The positivity rate was higher for hookworms eggs (13.5% and Toxocara eggs (8.8%; Trichuris, Ascaris and Capillaria eggs were also detected. This study shows the risks to which the population is exposed in relation to zoonotic geohelminths, and suggests that sanitation and health education measures should be implemented in the municipality.A frequência de contaminação parasitária de áreas públicas de Pelotas, Rio Grande do Sul, Brasil, foi avaliada entre junho de 2010 e maio de 2011, com coletas mensais de amostras de solo de oito praças. Das 400 amostras submetidas à técnica de centrífugo-flutuação em solução de dicromato de sódio com densidade de 1,35, 176 (44% apresentaram pelo menos uma forma parasitária e, das amostras positivas, 29 (16,5% estavam poliparasitadas. Os resultados demonstraram relevante índice de contaminação do solo em todas as praças avaliadas, com maiores índices de positividade para ovos de ancilostomídeos (13,5% e ovos de Toxocara (8,8%, sendo também identificados ovos de Trichuris, Ascaris e Capillaria. O estudo demonstrou a contaminação ambiental de praças públicas e os riscos a que a população está exposta em relação a doenças causadas por geoparasitos zoonóticos e sugere que medidas de saneamento e educação em saúde devem ser implementadas no município.

  11. Immunofluorescent Antibody Test (IFAT for Trypanosoma cruzi in dogs from urban and rural areas of Pelotas, RS

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    Charlene Nascimento dos Santos

    2015-07-01

    Full Text Available Chagas disease (CD is a zoonosis with the protozoan Trypanosoma cruzi as the causative agent. Dogs are considered the main domestic reservoir for T. cruzi in most Latin American countries and in some areas of the United States. In southern Brazil, despite being an endemic area of the disease, the prevalence in dogs is still unknown. This study aimed to evaluate the frequency of T. cruzi antibodies in dogs from urban and rural areas of Pelotas, RS, Brazil. A total of 227 canine sera were used for serological tests, of which 99 were from urban areas and 128 were from rural areas of Pelotas. Information regarding the environment and the possible risk factors (origin, rural contact, age, breed, confinement and gender to which the dogs were exposed were recorded. Indirect immunofluorescence was used to assess the presence of specific immunoglobulins (IgG anti-T. cruzi in the serum of dogs. Of the 227 sera analyzed, 81 (35.7% exhibited anti-T. cruzi, which represented 34.3% of the dogs from the urban area and 36.7% of the dogs from the rural area. Among the variables analyzed, rural contact and male gender showed an association with seropositivity for T. cruzi. The detection of T. cruzi antibodies in the serum of these dogs emphasizes the need to study trypanosomiasis in this important domestic reservoir of Chagas disease.

  12. Esporotricose felina com envolvimento humano na cidade de Pelotas, RS, Brasil

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    Xavier Melissa Orzechowski

    2004-01-01

    Full Text Available A esporotricose é uma micose subcutânea, causada pelo fungo dimórfico Sporothrix schenckii. O presente estudo descreve a ocorrência de esporotricose felina na cidade de Pelotas (Rio Grande do Sul - Brasil, e a transmissão para um atendente da clínica veterinária, ocasionada pela arranhadura do animal doente. O felino apresentava deformação do espelho nasal e lesões cutâneas, enquanto o humano apresentava uma lesão ulcerada na região metacarpiana dorsal esquerda. Foram colhidas crostas e/ou exsudato das lesões do felino e do atendente para diagnóstico micológico, os quais foram cultivados em ágar Sabouraud dextrose acrescido de cloranfenicol e incubados a 25 e 37degreesC, durante 10 dias. O isolamento do S. schenckii confirmou o diagnóstico clínico de esporotricose cutânea disseminada no felino e cutânea localizada no atendente. Esta nota pretende alertar profissionais relacionados à clínica de pequenos animais quanto à existência da doença e o alto risco de transmissão pela mordedura e/ou arranhadura de animais infectados.

  13. Listeria spp. no processamento de lingüiça frescal em frigoríficos de Pelotas, RS, Brasil Listeria spp. in the processing of fresh sausages in slaughterhou ses from Pelotas, RS, Brazil

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    Wladimir Padilha da Silva

    2004-06-01

    Full Text Available Alimentos intensamente manipulados, como as lingüiças mistas do tipo frescal são freqüentemente responsáveis pela veiculação de enfermidades transmitidas por alimentos. Devido ao risco à saúde pública que a bactéria Listeria monocytogenes representa, este trabalho teve como objetivo estudar a presença de Listeria spp., em especial de L. monocytogenes, durante o processamento de lingüiças mistas do tipo frescal, em três frigoríficos com inspeção sanitária estadual, em Pelotas-RS. Para isso, analisou-se a matéria-prima utilizada no preparo da lingüiça, os equipamentos da linha de processamento e o produto final. Isolou-se Listeria spp. em 100% das 41 amostras analisadas, nos 3 estabelecimentos estudados. Dentre as diferentes espécies, L. innocua foi aquela isolada com maior freqüência, em 97,6% das amostras, seguida por L. monocytogenes em 29,3% e L. welshimeri em 24,4%. A presença destes microrganismos nas amostras analisadas, em especial no produto final, demonstra a necessidade de readequação nas práticas de limpeza e sanificação das plantas de processamento analisadas, bem como representa risco potencial de listeriose ao consumidor.Food that is highly manipulated, such as fresh sausages, is frequently responsible for spreading food borne diseases. Due to the threat that the bacterium Listeria monocytogenes represents to public health, the aim of this work was to study the presence of Listeria spp., especially Listeria monocytogenes, during processing of fresh sausages, in three slaughterhouses with state food inspection, in the city of Pelotas, Brazil. The raw material used for the sausage elaboration, the equipment used in the processing and the end products were analyzed. The results showed Listeria spp. in 100% of the 41 samples analyzed. Among the different species, L. innocua was the most frequent, isolated from 97.6% of the samples, followed by the L. monocytogenes and L. welshimeri that were isolated from

  14. Biochronostratigraphy and paleoenvironment analysis of Neogene deposits from the Pelotas Basin (well 2-TG-96-RS, Southernmost Brazil

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    WAGNER G. SILVA

    2015-09-01

    Full Text Available This paper presents the integration of micropaleontological (palynology and foraminifera and isotopic (87Sr/86Sr analysis of a selected interval from the well 2-TG-96-RS, drilled on the onshore portion of the Pelotas Basin, Rio Grande do Sul, Brazil. A total of eight samples of the section between 140.20 and 73.50 m in depth was selected for palynological analysis, revealing diversified and abundant palynomorph associations. Species of spores, pollen grains and dinoflagellate cysts are the most common palynomorphs found. Planktic and benthic calcareous foraminifera were recovered from the lowest two levels of the section (140.20 and 134.30 m. Based on the stratigraphic range of the species of dinoflagellate cysts and sporomorphs, a span age from Late Miocene to Early Pliocene is assigned. The relative age obtained from the 87Sr/86Sr ratio in shells of calcareous foraminifers indicates a Late Miocene (Messinian correspondence, corroborating the biostratigraphic positioning performed with palynomorphs. Paleoenvironmental interpretations based on the quantitative distribution of organic components (palynomorphs, phytoclasts and amorphous organic matter throughout the section and on foraminiferal associations indicate a shallow marine depositional environment for the section. Two palynologicals intervals were recognized based on palynofacies analysis, related to middle to outer shelf (140.20 to 128.90 m and inner shelf (115.75 to 73.50 m conditions.

  15. AVALIAÇÃO DA QUALIDADE FÍSICO-QUÍMICA DO MEL PRODUZIDO NA CIDADE DE PELOTAS/RS

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    Willian RICHTER

    2011-12-01

    Full Text Available O trabalho teve por objetivo avaliar a qualidade físico-química de dezenove amostras de méis produzidas na cidade de Pelotas/RS. Foram realizadas análises de umidade, cinzas, acidez total, açúcares redutores e não redutores, hidroximetilfurfural, condutividade elétrica, reações de Fiehe e Lund. Das dezenove amostras avaliadas, dezoito pela determinação da condutividade elétrica, foram classificadas como sendo mel de melato, mel de castanha ou mistura das mesmas. Em relação às demais análises, uma amostra foi considerada adulterada por apresentar inconformidade em relação ao teor umidade, cinzas, açúcares redutores, reação de Lund e reação de Fiehe confirmada pela quantificação de hidroximetilfurfural. Assim, devido à possibilidade de fraude, deve haver maior fiscalização dos órgãos competentes, quanto à produção e comercialização de mel. O consumidor deverá atentar-se ao adquirir mel em feiras livres e estabelecimentos onde os produtos são comercializados sem certificação.

  16. Fatores associados ao sedentarismo no lazer de adultos na coorte de nascimentos de 1982, Pelotas, RS Factores asociados al sedentarismo en el tiempo de ocio de adultos en la cohorte de nacimientos de 1982, Pelotas, Sur de Brasil Factors associated to leisure-time sedentary lifestyle in adults of 1982 birth cohort, Pelotas, Southern Brazil

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    Mario R Azevedo

    2008-12-01

    Full Text Available OBJETIVO: Analisar fatores relacionados à prática de atividade física e ao sedentarismo no lazer. MÉTODOS: Estudo prospectivo de coorte dos nascidos em 1982 na cidade de Pelotas (RS. Os dados foram coletados no nascimento e na visita em 2004-5, na qual foram avaliados 77,4% dos indivíduos da coorte, totalizando 4.297. Informações sobre a prática de atividades físicas, no período de lazer, foram obtidas por meio do Questionário Internacional de Atividades Físicas. Foram considerados sedentários os indivíduos com escore de prática de atividade física semanal inferior a 150 min. Foram consideradas variáveis independentes: sexo, cor da pele, peso ao nascer, renda familiar no ano do nascimento e mudança de renda entre o nascimento e os 23 anos. A regressão de Poisson com ajuste robusto da variância foi utilizada na avaliação dos fatores de risco para o sedentarismo. RESULTADOS: Os homens relataram 334 min do escore de atividades físicas no período de lazer por semana versus 112 min entre as mulheres. A prevalência de sedentarismo foi de 80,6% entre as mulheres e 49,2% entre os homens. Observou-se tendência de aumento do escore de atividades físicas conforme aumentou a renda ao nascer. Indivíduos atualmente pobres ou que se tornaram pobres na idade adulta foram mais sedentários. CONCLUSÕES: O sedentarismo no período de lazer entre adultos jovens mostrou-se elevado, principalmente no sexo feminino. A atividade física no lazer é determinada pelas condições socioeconômicas atuais.OBJETIVO: Analizar factores relacionados con la práctica de actividad física y al sedentarismo en el tiempo de ocio. MÉTODOS: Estudio prospectivo de cohorte de los nacidos en 1982 en la ciudad de Pelotas (Sur de Brasil. Los datos fueron colectados en el nacimiento y en la visita en 2004-5, en la cual fueron evaluados 77,4% de los individuos de la cohorte, totalizando 4.297. Informaciones sobre la práctica de actividades físicas, en el per

  17. Avaliação nutricional de adultos da coorte de nascimentos de 1982, Pelotas, RS Evaluación nutricional de adultos de la cohorte de nacimientos de 1982, Pelotas, Sur de Brasil Nutritional evaluation follow-up of the 1982 birth cohort, Pelotas, Southern Brazil

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    Denise P Gigante

    2008-12-01

    Full Text Available OBJETIVO: Estimar a prevalência de desnutrição por déficit ou excesso de peso e sua associação com fatores demográficos e socioeconômicos. MÉTODOS: Estudo longitudinal de coorte de jovens nascidos em 1982 em Pelotas, RS. Em 2004-5 foram entrevistados 4.198 dos 5.914 indivíduos dessa coorte, que tiveram suas medidas de peso e estatura coletadas para cálculo do índice de massa corporal (IMC. Definiu-se baixo peso pelo valor de IMC inferior a 18,5 kg/m²; excesso de peso, pelo IMC entre 25 e 30kg/m²; e obesidade pelo IMC>30kg/m². Os efeitos de variáveis socioeconômicas (renda familiar e escolaridade, demográfica (cor da pele, peso ao nascer e amamentação sobre baixo peso, excesso de peso e obesidade foram analisados utilizando regressão de Poisson separadamente para homens e mulheres. RESULTADOS: As prevalências de baixo peso, obesidade e excesso de peso foram 6,0%, 8,2% e 28,9%, respectivamente. Na análise ajustada somente o peso ao nascer manteve-se associado com baixo peso em homens e mulheres. Homens pobres tiveram maior risco de baixo peso, mas ficaram protegidos da obesidade e do excesso de peso. Por outro lado, o risco de obesidade e excesso de peso foi maior entre as mulheres pobres. CONCLUSÕES: Os resultados reforçam a importância da determinação socioeconômica sobre o estado nutricional, chamando atenção como esses fatores agem de forma distinta em homens e mulheres de diferentes situações nutricionais, indicando atenção no que se refere a medidas específicas na prevenção, melhorando o acesso à informação sobre educação alimentar e nutricional para toda população.OBJETIVO: Estimar la prevalencia de desnutrición por déficit o exceso de peso y su asociación con factores demográficos y socioeconómicos. MÉTODOS: Estudio longitudinal de cohorte de jóvenes nacidos en 1982 en Pelotas (Sur de Brasil. En 2004-5 fueron entrevistados 4.198 de los 5.914 individuos de esa cohorte, que tuvieron sus

  18. Prevalência de chiado no peito em adultos da coorte de nascimentos de 1982, Pelotas, RS Prevalencia del silbido en el pecho en adultos de la cohorte de nacimientos de 1982, Pelotas, Sur de Brasil Prevalence of wheezing in the chest among adults from the 1982 Pelotas birth cohort, Southern Brazil

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    Ana M B Menezes

    2008-12-01

    Full Text Available OBJETIVO: Estimar a prevalência de chiado no peito em adultos jovens, explorando o efeito de algumas variáveis sobre a ocorrência desta morbidade. MÉTODOS: Estudo prospectivo de coorte dos nascidos em 1982 na cidade de Pelotas (RS. Foram localizados 4.297 (77,4% dos membros da coorte em 2004-5, cujos dados foram coletados por meio de entrevista, utilizando o questionário ISAAC (International Study of Asthma and Allergies in Childhood Steering Committee. A associação entre o desfecho "ocorrência de chiado no peito nos 12 meses anteriores à entrevista" e variáveis socioeconômicas, demográficas e características ao nascimento foi calculada por análise multivariável utilizando regressão de Poisson. RESULTADOS: A prevalência de chiado no último ano foi de 24,9%. Entre aqueles que relataram chiado, 54,6% referiram dificuldade para dormir e 12,9% para falar devido ao chiado. A prevalência de chiado no peito foi significativamente maior entre as mulheres, mantendo associação na análise ajustada com cor de pele não branca, com história familiar de asma e nível socioeconômico baixo. Entre os homens, não houve associação significativa na análise ajustada para cor de pele e renda familiar ao nascimento; história familiar de asma e pobreza durante a vida mostraram associação significativa com chiado no peito. Para ambos os sexos, não houve associação com as variáveis peso ao nascer e duração da amamentação. CONCLUSÕES: A prevalência de chiado no peito foi alta e as pessoas com renda familiar baixa ao nascer tiveram maior risco de chiado no peito no último ano.OBJETIVO: Estimar la prevalencia del silbido en el pecho en adultos jóvenes, explorando el efecto de algunas variables sobre la ocurrencia de esta morbilidad. MÉTODOS: Estudio prospectivo de cohorte de los nacidos en 1982 en la ciudad de Pelotas (Sur de Brasil. Fueron localizados 4.297 (77,4% de los miembros de la cohorte en 2004-5, cuyos datos fueron

  19. Respiratory syncytial virus infection in children under one year of age hospitalized for acute respiratory diseases in Pelotas, RS

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    Silvia Elaine Cardozo Macedo

    2003-01-01

    Full Text Available INTRODUCTION: Acute respiratory diseases (ARDs are a major cause of infant morbidity and mortality. OBJECTIVE: The present case-controlled study investigated the hospitalizations by ARDs in children under one year of age and the association with the respiratory syncytial virus (RSV in za Pelotas, RS. METHODS: All children under one year of age hospitalized due to ARDs from August 1997 to July of 1998 were followed-up in the four hospitals of the city. A standardized questionnaire was applied to the children's mother regarding symptoms of the actual illness in addition to social and demographic variables, nutrition, and previous morbidity. The final diagnosis of ARDs was performed by an arbiter (a pediatrician based on the hospital records of the children and the data on the questionnaire. Nasopharyngeal secretions were collected for RSV detection by direct immunofluorescence. RESULTS: The study included 650 children and the annual incidence rate of hospital admissions for ARDs was 13.9%. Admissions showed a seasonal pattern with most of the hospitalizations occurring from July to October. The main causes of admission were: pneumonia (43.7%, bronchiolitis (31.0%, asthma (20.3%, influenza (3.5%, otitis media (0.8% and laryngitis (0.6%. The overall prevalence of RSV was 30.7%, with 40.2% in bronchiolitis, 28.6% in influenza, 27.4% in asthma, 26.3% in pneumonia, and 25% in otitis media. CONCLUSIONS: The results of the present study confirm the high morbidity of ARDs in childhood and the seasonal pattern of ARDs hospitalizations and their association with RSV infection.

  20. Flutuação populacional circanual de coleópteros em granja avícola, em Pelotas, RS, Brasil Fluctuation of Coleoptera population in poultry house, in Pelotas, RS, Brazil

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    Carla de Lima Bicho

    Full Text Available Com o objetivo de conhecer a flutuação populacional de coleópteros na granja de aves do Conjunto Agrotécnico Visconde da Graça, em Pelotas, RS, foram utilizados seis métodos de coleta: 1 (fezes de galinhas com 0 a 7 dias; 2 (7 a 14 dias; 3 (14 a 21 dias; 4 (0 a 21 dias; 5 (fezes acumuladas e 6 (armadilhas de tubo. Análises de regressão polinomial foram realizadas independentemente dos métodos de coleta. O estudo foi realizado de agosto de 1998 a julho de 1999. Foram capturados 12.449 coleópteros representados pelas seguintes espécies Carcinops troglodytes (Paykull, 1811 (Histeridae (6.444; Alphitobius diaperinus (Panzer, 1797 (Tenebrionidae (2.896; Somotrichus unifasciatus (Dejean, 1792 (Carabidae (1.190; Gnathocerus cornutus (Fabricius, 1798 (Tenebrionidae (947; Euxestus sp. (Cerylonidae (394; Euspilotus rubriculus (Marseul, 1855 (Histeridae (213; Ontholestes sp. (Staphylinidae (190; Dactylosternum sp. (Hydrophilidae (93; Mezium americanum (Laporte, 1840 (Ptinidae (43; Palorus subdepressus (Wollaston, 1864 (Tenebrionidae (27; Tenebroides mauritanicus (L., 1758 (Trogossitidae (8; Xyleborus ferrugineus (Fabricius, 1801 (Scolytidae (1; e espécimens não identificados de Dermestidae (3. O maior número de espécies ocorreu nos meses de março e julho e o menor, no mês de setembro. Em março foi registrada a maior abundância de coleópteros (2.159, enquanto que o menor índice de captura foi assinalado em outubro (633. A flutuação populacional foi estimada para C. troglodytes, A. diaperinus, S. unifasciatus, G. cornutus, Euxestus sp., E. rubriculus, Ontholestes sp. e Dactylosternum sp.The population fluctuation of Coleoptera in poultry house "Conjunto Agrotécnico Visconde da Graça" in Pelotas, Rio Grande do Sul, Brazil is investigated. Six collection methods were utilized: 1 (0 to 7 day-old chicken feces; 2 (7 to 14 day-old feces; 3 (14 to 21 day-old feces; 4 (0 to 21 day-old feces, 5 (accumulated feces; and 6 (tube trap. An

  1. Condições higiênico-sanitárias no comércio ambulante de alimentos em Pelotas-RS Hygienic-sanitary conditions of street foods from Pelotas, RS

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    Kelly Lameiro Rodrigues

    2003-12-01

    Full Text Available O comércio de alimentos prontos para o consumo por vendedores ambulantes pode constituir um alto risco para a saúde dos consumidores, visto que as pessoas envolvidas nesta atividade geralmente não tem preparo para a manipulação correta de alimentos. Neste trabalho foram investigadas as condições de preparo e a qualidade higiênico-sanitária de lanches comercializados por vendedores ambulantes em Pelotas. Foram colhidas de 60 estabelecimentos, uma amostra de água, uma da superfície de manuseio e um lanche (cachorro-quente. Nos cachorros-quentes foram realizadas contagens de bactérias aeróbias mesófilas (BAM, Staphylococcus coagulase positiva (STA, coliformes totais (CT, coliformes a 45ºC (CF, e investigada a presença de Salmonella sp. Na água e superfície foram realizadas contagens de BAM, CT e CF. Entre as 60 amostras de cachorros-quentes analisadas, 53%, 48%, 37% e 25% estavam fora do padrão para CT, BAM, STA e CF, respectivamente. Em nenhuma amostra foi detectada a presença de Salmonella. As amostras de água apresentaram apenas 3 (5% amostras fora do padrão para BAM, e 27% e 23% fora do padrão para CT e CF, respectivamente. Em relação às superfícies, 70% foram consideradas insatisfatórias para contagem de BAM e 68% e 67% para CT e CF. Os resultados sugerem que as condições higiênicas existentes em muitos estabelecimentos não são adequadas, o que se reflete em uma proporção relativamente alta de lanches com qualidade microbiológica insatisfatória para o consumo.Street-vending of ready-to-eat (RTE foods can be a risk to the consumers health, since people usually involved in this activity does not have proper knowledge in safe handling of foods. Despite this, only a few studies have been made on the microbiological quality of these foods and places where they are prepared. In this paper we report on the higienic-sanitary quality of hot-dogs sold by street-vendors from Pelotas,RS. Samples of hot-dogs, water and

  2. TURISMO NO ESPAÇO RURAL, PRÁTICAS LOCAIS E IMIGRAÇÃO ITALIANA: O Caminho Colonial do Vinho, Pelotas/RS.

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    Tiaraju Salini Duarte

    2011-11-01

    Full Text Available Resumo: As novas características e funções do espaço rural despertam interesse em diferentes áreas do conhecimento, a partir da década de 1980, devido às transformações que levaram a agricultura a se adaptar às novas exigências do mercado. A multifuncionalidade da agricultura é um fenômeno atual, presente no espaço rural, ou seja, as atividades agrícolas passam a não serem as únicas fontes geradoras de renda para o agricultor. Partindo dessas concepções, o turismo no espaço rural do município de Pelotas/RS, mais especificamente no Distrito do Rincão da Cruz, representa a possibilidade de valorização das paisagens naturais e da herança cultural da imigração italiana presentes no local. Para a população urbana, o espaço rural é lócus de lazer e, simultaneamente, depositário de um saber-fazer em relação aos produtos locais, como a uva e seu processamento. Palavras-chave: Turismo Rural. Imigração italiana. Vitivinicultura. Pelotas/RS

  3. Prevalência de consultas médicas e fatores associados, Pelotas (RS), 1999-2000 Prevalencia de consultas médicas y factores asociados en Pelotas (Sur de Brasil), 1999-2000 Prevalence of medical visits and associated factors, Pelotas, Southern Brazil, 1999-2000

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    Juvenal Soares Dias da Costa; Mauri Caldeira Reis; Claudio Viana Silveira Filho; Rogério da Silva Linhares; Fábio Piccinini

    2008-01-01

    OBJETIVO: Estimar a prevalência de consultar com médico e analisar fatores a ela associados. MÉTODOS: Estudo transversal de base populacional realizado de dezembro de 1999 a abril de 2000, na cidade de Pelotas (RS). Foram incluídos 1.962 indivíduos de ambos os sexos, de 20 a 69 anos, residentes na zona urbana. Os dados foram coletados por meio de questionários padronizados e pré-codificados. O desfecho "consultar com médico nos 12 meses antes da entrevista" foi analisado com fatores socioecon...

  4. Causas de mortalidade perinatal em Pelotas, RS (Brasil: utilização de uma classificação simplificada Causes of perinatal mortality in Pelotas, Rio Grande do Sul, Brazil: utilization of a simplified classification

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    Fernando Celso Barros

    1987-08-01

    Full Text Available O coeficiente de mortalidade perinatal dos 7.392 nascimentos ocorridos nos hospitais de Pelotas, RS, (Brasil no ano de 1982, foi de 33,7 por 1.000, e 8,8% dos recém-nascidos pesaram menos de 2.500 g. As causas de mortalidade perinatal foram analisadas utilizando-se a classificação simplifícada proposta por Wigglesworth. Trinta e seis por cento dos óbitos perinatais ocorreram antes do início do trabalho de parto (natimortos antepartum, e destes, 60% pesaram mais de 2.000 g. A segunda causa mais importante de morte foi imaturidade, com 31% dos óbitos. Neste grupo, 21% pesaram mais de 2.000 g. Estes achados, assim como as altas taxas de mortalidade perinatal para grupos específicos de peso ao nascer, sugerem que algumas falhas estão ocorrendo no atendimento de saúde da população materno-infantil em Pelotas, tanto em clínicas de pré-natal como no atendimento do parto.The causes of perinatal mortality among the 7,392 hospital births which occurred in Pelotas, RS, Brazil, during 1982, were analysed using the simplified classification described by Wigglesworth. The main advantage of this classification is that it can be used even in places where post-mortems are seldom performed. The perinatal deaths were classified into five groups: a macerated fetuses without malformations, b congenital malformations, c immaturity, d asphyxia and e other causes of death. The perinatal mortality rate was 33.7 per 1,000 births, nearly equally divided between fetal and early neonatal deaths, and 8.8% of the babies were of low birthweight. Thirty-six percent of the perinatal deaths were antepartum stillbirths, and 60% of these weighed 2,000 g. or more. The second most important cause was immaturity, which accounted for 31% of the deaths. In this latter group 21% weighed 2,000 g or more at birth. These findings, as well as the high birthweight-specific perinatal mortality rates, strongly suggest that there are deficiencies in the antenatal and delivery care

  5. Prevalência de cardiopatias congênitas em portadores da síndrome de Down na cidade de Pelotas (RS Prevalence of congenital heart defects in patients with Down syndrome in the municipality of Pelotas, Brazil

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    Luciana T. Vilas Boas

    2009-10-01

    Full Text Available OBJETIVO: Determinar a prevalência de cardiopatias congênitas em portadores da síndrome de Down na cidade de Pelotas (RS, descrevendo os tipos mais frequentes e avaliando os fatores associados. MÉTODOS: Estudo transversal que incluiu crianças portadoras de síndrome de Down nascidas e residentes em Pelotas no período de janeiro de 2000 a dezembro de 2005. Os dados foram obtidos através de entrevistas realizadas nos domicílios dos pacientes, com as mães ou seus familiares legais. Para o estudo dos fatores relacionados à presença de cardiopatia congênita, foram realizadas análises univariada e bivariada. RESULTADOS: Foram entrevistadas 47 mães de pacientes com síndrome de Down, sendo que 22 (46,8% pacientes apresentavam diagnóstico de cardiopatia congênita. Destes, 28% receberam avaliação cardiológica precoce, antes dos 3 meses de vida. A cardiopatia mais frequente foi a comunicação interatrial (17%; o defeito do septo atrioventricular ocorreu em cinco pacientes. A análise bivariada entre o desfecho presença de cardiopatia congênita e os fatores preditores idade materna, idade paterna, cor dos pais e da criança, presença de outras malformações e sexo da criança mostraram que as associações não foram estatisticamente significativas. CONCLUSÕES: As prevalências de síndrome de Down e de cardiopatia congênita em nossa região apresentam-se semelhantes às encontradas por outros autores, ressaltando-se a importância da suspeita diagnóstica e do encaminhamento precoce por parte dos pediatras para avaliação cardiológica. Destaca-se também o baixo número de pacientes que realizaram cariótipo. Além disso, o número de malformações associadas foi inferior ao encontrado por outros autores.OBJECTIVE: To determine the prevalence of congenital heart defects in patients with Down syndrome in the municipality of Pelotas, Brazil, describing the most frequent types and assessing the associated factors. METHODS: Cross

  6. Critérios de escolha de postos de saúde para acompanhamento pré-natal em Pelotas, RS

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    Santos, Iná S; Roberto Carlos Baroni; Ivanete Minotto; Ana Guerda Klumb

    2000-01-01

    OBJETIVO: Caracterizar o cuidado pré-natal em uma amostra representativa de mães, identificando o serviço de saúde onde estas realizaram o acompanhamento da gestação e os motivos que as levaram a escolher este local. MÉTODOS: Estudo transversal, realizado nos meses de março e abril de 1997, nas quatro principais maternidades de Pelotas, RS, através de entrevista a 401 mães no pós-parto imediato. RESULTADOS: Fizeram acompanhamento pré-natal, em um posto de saúde 51% das mães, sendo a proximida...

  7. GESTÃO DE RESÍDUOS SÓLIDOS URBANOS: ESTUDO DO CASO DA RECICLAGEM EM PELOTAS, RS

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    Godecke, Marcos Vinicius; Walerko, Vandressa Siqueira

    2015-01-01

    Diante das evidências relacionadas ao baixo índice de reaproveitamento dos materiais recicláveis no Brasil, este estudo toma o caso do município de Pelotas, região sul do estado do Rio Grande do Sul, para discutir programas que possam ser implementados para a ampliação da eficiência do serviço de coleta seletiva domiciliar de recicláveis. Além de referenciais bibliográficos e documentais, utiliza pesquisa de campo e entrevistas com os principais agentes envolvidos, incluindo técnicos municipa...

  8. PREVALÊNCIA DE SALMONELLA EM PRODUTOS DE FRANGOS E OVOS DE GALINHA COMERCIALIZADOS EM PELOTAS, RS, BRASIL PREVALENCE OF SALMONELLA IN CHICKEN PRODUCTS AND HEN'S EGGS FROM PELOTAS, RS, BRAZIL

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    Ana Cristina Baú

    2001-04-01

    Full Text Available A prevalência de Salmonella em produtos de frangos e ovos de galinhas, os sorovares mais freqüentes e sua sensibilidadea a antimicrobianos, foram investigados em Pelotas, Brasil, no período de maio de 1997 a outubro de 1998. Um total de 124 amostras de produtos de frangos obtidas em supermercados e açougues e 94 amostras de 6 unidades de ovos de galinhas obtidas em supermercados e feiras-livres foram analisadas através do método convencional de cultivo. Entre as amostras de produtos de frangos analisadas, 13 (10,48% continham salmonelas. Os 13 isolamentos de salmonelas realizados foram sorotipificados como S. enteritidis (10, S. anatum (1 e S. enterica subespécie enterica sorovar 3,10:e,h:- (2. Todas as cepas isoladas foram resistentes à penicilina G e sensíveis aos demais antimicrobianos testados. Em amostras de ovos, não foram detectadas salmonelas.The prevalence of Salmonella in chicken products and hen's eggs, the most frequent serovars and their antimicrobial sensitivity, were investigated in the city of Pelotas, Brazil from May 1997 through October 1998. A total of 124 samples of chicken products obtained from local supermarkets and butcher shops, and 94 samples of eggs (6 units each obtained from supermarkets and street vendors, were examined through standard cultivation procedures. Salmonella were detected in 13 (10,48% samples of chicken products. Among the 13 strains of salmonellae isolated, 10 were serotyped as S. enteritidis, 1 was S. anatum and 2 were S. enterica subsp. enterica sorovar 3,10:e,h:-. All strains isolated were resistant to penicillin G and susceptible to the others antimicrobial drugs tested. Hen's eggs were not found contaminated with salmonellae.

  9. "JÁ QUE A DESGRAÇA ASSIM QUERIA" UM FEITICEIRO FOI SACRIFICADO: CURANDEIRISMO, ETNICIDADE E HIERARQUIAS SOCIAIS (PELOTAS - RS, 1879

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    Paulo Roberto Staudt Moreira

    2013-01-01

    Full Text Available On Wednesday, January 15, 1879, a slave born in the province of Pernambuco and who worked making salted meat in Pelotas, Rio Grande do Sul, stabbed to death a freed African (of the Mina nation who was renowned as a sorcerer and amulet maker. Court cases involving sorcerers provide windows into slave society in intimate detail. This article, based on an analysis of case studies, examines the relational field of possibilities in which captives lived, whether they were in prison or at work making salted meat. This kind of documentation also allows us to come closer to the market of beliefs and the role of sorcerers/ healers in sociability and in contouring ethnic and social identity.

  10. Os jornais estudantis Ecos Gonzagueanos e Estudante: apontamentos sobre o ensino secundário católico e laico (Pelotas/RS, 1930 a 1960 - The student newspaper Ecos Gonzagueanos e Estudante: notes on the secondary schools catholic and secular (Pelotas/RS

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    Giana Lange do Amaral, Brasil

    2013-04-01

    Full Text Available O presente texto trata do uso de jornais estudantis como fonte para estudos em História da Educação, bem como da importância da leitura de jornais escolares. Privilegia-se a análise de dois jornais de escolas de ensino secundário católico e laico de Pelotas/RS: o Ecos Gonzagueanos e o Estudante. Nas investigações que abordam as práticas culturais, seus sujeitos e sua produção, os jornais estudantis são considerados elementos potenciais para a apreensão das práticas, dos discursos e do cotidiano escolar. É possível observar valores, costumes e interesses que balizavam as relações dos jovens estudantes, bem como os reflexos das apropriações feitas a partir da cultura escolar da instituição a qual estavam ligados.Palavras-chave: jornais estudantis, fontes históricas, ensino secundário, ensino laico e católico. THE STUDENT NEWSPAPER ECOS GONZAGUEANOS E ESTUDANTE: NOTES ON THESECONDARY SCHOOLS CATHOLIC AND SECULAR (PELOTAS/RS, 1930 A 1960AbstractThis paper discusses the use of student newspapers as a source for studies in history of education, as well as the importance of reading school newspaper. Focuses on the analysis of two newspapers of catholic secondary schools and secular of Pelotas/RS: Ecos Gonzagueanos and Estudante. In investigations that address cultural practices, their subjects and their production, student newspapers are considered potential elements for the seizure of the practices, discourses and daily life at school. You can see the values, customs and interests that oriented the relationships of young students as well as the reflections of the appropriations made from the school culture of the institution to which they were connected.Key-words: student newspapers, historical sources, secondary education, secular and catholic education. LOS PERIÓDICOS ESTUDANTILES ECOS GONZAGUEANOS E ESTUDANTE: NOTAS SOBRE LAS ESCUELAS SECUNDARIAS CATÓLICAS E SECULARES (PELOTAS/RS, 1930 A 1960ResumenEste art

  11. Canine coronavirus (CCoV in dogs vaccinated and unvaccinated domiciliated in Pelotas, RS, Brazil Coronavirus canino (CCoV em cães vacinados e não vacinados domiciliados em Pelotas, RS

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    Geferson Fischer

    2010-12-01

    Full Text Available Canine coronavirus (CCoV has been reported causing enteric disease mainly in young pups. In this study, to investigate immunity and exposure to CCoV, was estimated the frequency of serum antibodies to CCoV in 121 dogs in the Pelotas, South of Brazil, by serum neutralization test (SN: 22 had not been vaccinated, 69 had been vaccinated at least once, and 30 had unknown vaccination history. Antibodies were present in 47,8% (33/69 of the vaccinated dogs, in 45,5% (10/22 of the unvaccinated, and in 43,3% (13/30 of the dogs with unknown historical vaccination. There was no significant relationship between these antibodies and sex, age, habitat, and season of collection. The results proved the circulation of the CCoV among this dog population and indicated that the infection affects a significant group of animals. The large proportion of seronegative vaccinated dogs indicates failure of CCoV vaccine in inducing neutralizing antibodies, suggesting that immunizations to CCoV should be reevaluated. The authors indicate the need for further studies in order to evaluate the impact of the infection caused by CCoV, as well as to propose and evaluate preventive measures. Coronavírus canino (CCoV foi relatado como causa de doença entérica principalmente em cães jovens. Nesse estudo, para investigar imunidade e exposição ao CCoV, foi estimado a frequência de anticorpos em 121 cães de Pelotas, sul do Brasil, pelo teste de soro-neutralização (SN: 22 não haviam sido vacinados, 69 haviam sido vacinados com pelo menos uma dose, e 30 possuíam histórico de vacinação desconhecido. Foram detectados anticorpos em 47,8% (33/69 dos cães vacinados, em 45,5% (10/22 dos não vacinados, e em 43,3% (13/30 dos cães com histórico de vacinação desconhecido. Não houve associação significativa entre os anticorpos e sexo, idade, habitação e estação da coleta. Os resultados confirmam a circulação do CCoV entre essa população de cães e indicam que a infec

  12. Estudo longitudinal das crianças nascidas em 1982 em Pelotas, RS, Brasil: metodologia e resultados preliminares Study in length of children born in Pelotas, Rio Grande do Sul, Brazil, in 1982: metodology and preliminary results

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    César Gomes Victora

    1985-02-01

    Full Text Available Tentou-se acompanhar a morbi-mortalidade e o crescimento de uma coorte de 6.011 crianças urbanas nascidas em 1982 nos hospitais de Pelotas, RS, através de visitas domiciliares aos 12 meses (para uma amostra de 30% das crianças e aos 20 meses (para toda a população. Estas crianças representaram mais de 99% de todos os nascimentos urbanos naquele ano. Foi possível localizar 81% das crianças aos 12 meses e 86% aos 20 meses, devido a uma mudança na estratégia de trabalho de campo. A metodologia empregada e as principais dificuldades encontradas são descritas e as características ao nascer das crianças localizadas no acompanhamento são comparadas com as características das crianças não localizadas. A potencialidade de uso dos dados coletados é exemplificada através de alguns resultados preliminares mostrando as associações entre o peso ao nascer, a renda familiar e o estado nutricional aos 12 meses. O estudo mostra que é possível acompanhar, com uma perda relativamente pequena, uma coorte de crianças com base populacional em uma cidade brasileira de tamanho médio.A cohort of 6,011 urban children born in 1982 in the hospitals of Pelotas, Rio Grande do Sul, was followed up so that their morbidity, mortality and growth could be assessed. These children accounted for over 99% of all births in the city. A 30% sample of the children were visited at home when approximately 12 months old, and the whole population was visited at about 20 months of age. It was possible to locate 81% of the children at 12 months. This proportion increased to 86% at 24 months, due to a change in the logistics of the field work which then included visiting all 69,000 households in the city to locate children whose families had moved within the urban area. The methodology and main difficulties encountered are discussed, and the characteristics at birth of children who were located at the first follow-up visit was compared to those of children lost to

  13. O perfil oftalmológico dos candidatos à carteira de motorista na cidade de Pelotas - RS

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    Duarte Wladimir Ribeiro

    2002-01-01

    Full Text Available Objetivo: Estudar a acuidade visual dos candidatos a condutores de veículos da cidade de Pelotas e sua associação com as características sociodemográficas dos candidatos. Métodos: Foram examinados 1.010 candidatos a condutores em um serviço médico autorizado pelo Detran. Avaliou-se a acuidade visual, com e sem correção, bem como a sua relação com a visão de cores, sexo, idade e profissão dos entrevistados, por meio da análise de freqüências e de teste para associação. Resultados: Deste contingente 73,0% eram do sexo masculino, 65,0% tinham idade entre 18 e 45 anos, 51,4% ocupavam o setor de serviços e 25,0% utilizavam meio de correção visual. Sob o ponto de vista oftalmológico, 0,5% dos entrevistados não poderiam dirigir veículos automotores e 4,7% só poderiam obter habilitação para condução veicular, nas categorias A e B. Mostrou-se associada à acuidade visual baixa a maior longevidade. Conclusão: Baseado nos resultados, sugere-se menor intervalo de tempo para reavaliação visual dos motoristas das categorias C, D e E.

  14. EFEITO DO FRIO NA BROTAÇÃO DE GEMAS DE PEREIRA (Pyrus communis L. cv. Carrick, EM PELOTAS, RS EFFECT OF CHILLING ON THE BUD BREAKING OF PEAR CV. CARRICK, IN PELOTAS, RS

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    FLÁVIO GILBERTO HERTER

    2001-08-01

    Full Text Available Objetivou-se, no presente trabalho, identificar a profundidade de dormência e a velocidade de brotação em gemas de pereira, submetidas a diferentes períodos de frio à temperatura de 4ºC ±1. O experimento foi conduzido na Embrapa-Clima Temperado, em Pelotas, em 1999. Em 1º de junho, foram coletados 50 ramos, na cultivar Carrick, com aproximadamente 30 cm de comprimento. Após, foram divididos em 5 lotes de 10 ramos, sendo 4 mantidos a 4ºC± 1, e um em condições ambiente, constituindo, assim, 5 tratamentos: 0 (Testemunha; 272; 544; 816 e 1088 horas de frio (HF. No final de cada tratamento, os ramos foram divididos em pequenas estacas, contendo apenas uma única gema, sendo, após, armazenados em câmara climática a 25ºC ± 1. Avaliou-se a brotação, considerando-se o estádio de ponta verde. A partir destes dados, calculou-se o tempo médio de brotação (TMB, bem como a percentagem de gemas brotadas, em cada um dos tratamentos. Utilizou-se o índice de velocidade de brotação (IVB, para determinar a eficiência da temperatura na brotação das gemas. A profundidade de dormência, das gemas terminais, diminuiu à medida que se aumentou o período de frio. As gemas axilares não foram influenciadas pelo tempo de exposição ao frio. Com base nos dados do IVB e dos coeficientes angulares, as gemas terminais da cv. Carrick necessitam de 800 horas de frio para completar a brotação, nas condições que foram conduzidos os experimentos.The objective for this work was to identify the dormancy depth and the bud-sprouting rate of pear trees kept at chilling conditions (4ºC±1 for different periods. The experiment was carried out using buds of twigs of the previous growth season from a pear orchard of the Embrapa Clima Temperado Research Center. The twigs were collected on June 1, 1999. The treatments were five period of chilling: 0 (control; 272; 544; 816; or 1088 hours at 4ºC±1. At the end of each treatment, the twigs were cut into

  15. Critérios de escolha de postos de saúde para acompanhamento pré-natal em Pelotas, RS

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    Iná S Santos

    2000-12-01

    Full Text Available OBJETIVO: Caracterizar o cuidado pré-natal em uma amostra representativa de mães, identificando o serviço de saúde onde estas realizaram o acompanhamento da gestação e os motivos que as levaram a escolher este local. MÉTODOS: Estudo transversal, realizado nos meses de março e abril de 1997, nas quatro principais maternidades de Pelotas, RS, através de entrevista a 401 mães no pós-parto imediato. RESULTADOS: Fizeram acompanhamento pré-natal, em um posto de saúde 51% das mães, sendo a proximidade geográfica o critério mais freqüentemente referido para tal escolha (46,8%. Para 85% das mães, o serviço de saúde mais próximo de casa era um posto de saúde. No entanto, 52,2% dessas não utilizaram esse local para as consultas pré-natais alegando a má qualidade do atendimento (37,4%. Conforme referido pelas mães, entre os procedimentos de rotina do pré-natal recomendados pelo programa de saúde da rede pública, incluindo a promoção do aleitamento materno, apenas a imunização anti-tetânica foi realizada mais freqüentemente nos postos do que nos demais locais. CONCLUSÕES: Tendo em vista a expressiva utilização da rede pública para o acompanhamento pré-natal, necessitam ser implementados investimentos em educação continuada dos profissionais, com ênfase no cumprimento de normas técnicas pré-estabelecidas.

  16. Critérios de escolha de postos de saúde para acompanhamento pré-natal em Pelotas, RS

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    Santos Iná S

    2000-01-01

    Full Text Available OBJETIVO: Caracterizar o cuidado pré-natal em uma amostra representativa de mães, identificando o serviço de saúde onde estas realizaram o acompanhamento da gestação e os motivos que as levaram a escolher este local. MÉTODOS: Estudo transversal, realizado nos meses de março e abril de 1997, nas quatro principais maternidades de Pelotas, RS, através de entrevista a 401 mães no pós-parto imediato. RESULTADOS: Fizeram acompanhamento pré-natal, em um posto de saúde 51% das mães, sendo a proximidade geográfica o critério mais freqüentemente referido para tal escolha (46,8%. Para 85% das mães, o serviço de saúde mais próximo de casa era um posto de saúde. No entanto, 52,2% dessas não utilizaram esse local para as consultas pré-natais alegando a má qualidade do atendimento (37,4%. Conforme referido pelas mães, entre os procedimentos de rotina do pré-natal recomendados pelo programa de saúde da rede pública, incluindo a promoção do aleitamento materno, apenas a imunização anti-tetânica foi realizada mais freqüentemente nos postos do que nos demais locais. CONCLUSÕES: Tendo em vista a expressiva utilização da rede pública para o acompanhamento pré-natal, necessitam ser implementados investimentos em educação continuada dos profissionais, com ênfase no cumprimento de normas técnicas pré-estabelecidas.

  17. Prevalência de consultas médicas e fatores associados, Pelotas (RS, 1999-2000 Prevalencia de consultas médicas y factores asociados en Pelotas (Sur de Brasil, 1999-2000 Prevalence of medical visits and associated factors, Pelotas, Southern Brazil, 1999-2000

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    Juvenal Soares Dias da Costa

    2008-12-01

    Full Text Available OBJETIVO: Estimar a prevalência de consultar com médico e analisar fatores a ela associados. MÉTODOS: Estudo transversal de base populacional realizado de dezembro de 1999 a abril de 2000, na cidade de Pelotas (RS. Foram incluídos 1.962 indivíduos de ambos os sexos, de 20 a 69 anos, residentes na zona urbana. Os dados foram coletados por meio de questionários padronizados e pré-codificados. O desfecho "consultar com médico nos 12 meses antes da entrevista" foi analisado com fatores socioeconômicos, demográficos, presença de doenças crônicas e distúrbios psiquiátricos, estado nutricional, tabagismo, consumo de bebidas alcoólicas, e internação no ano anterior à entrevista. Foi realizada regressão de Poisson seguindo modelo hierarquizado, controlada por variáveis de confusão, considerando nível de significância OBJETIVO: Estimar la prevalencia de consultas con un médico y analizar factores asociados a ella. MÉTODOS: Se realizó estudio transversal de base poblacional de diciembre de 1999 a abril de 2000, en la ciudad de Pelotas (Sur de Brasil. Fueron incluidos 1.962 individuos de ambos sexos, de 20 a 69 años, residentes en la zona urbana. Los datos fueron colectados por medio de cuestionarios estandarizados y pre-codificados. La condición "consultar con médico en los 12 meses antes de la entrevista" fue analizada con factores socioeconómicos, demográficos, presencia de enfermedades crónicas y disturbios psiquiátricos, estado nutricional, tabaquismo, consumo de bebidas alcohólicas e internación en el año anterior a la entrevista. Fue realizada una regresión de Poisson siguiendo el modelo jerarquizado, controlado por variables de confusión, considerando nivel de significancia OBJECTIVE: To estimate the prevalence of visiting doctors and to analyze associated factors. METHODS: Cross-sectional, population-based study performed in the city of Pelotas, Southern Brazil, between December 1999 and April 2000. A total of

  18. Tabagismo na coorte de nascimentos de 1982: da adolescência à vida adulta, Pelotas, RS Tabaquismo en la cohorte de nacimientos de 1982: de la adolescencia a la vida adulta, Pelotas, Sur de Brasil Smoking prevalence in the 1982 birth cohort: from adolescence to adult life, Pelotas, Southern Brazil

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    Ana M B Menezes

    2008-12-01

    Full Text Available OBJETIVO: Avaliar a prevalência de tabagismo em adolescentes e adultos jovens pertencentes a uma coorte de nascimentos de base populacional. MÉTODOS: Estudo prospectivo de coorte dos nascidos em 1982 na cidade de Pelotas, RS, entrevistados em 1997, 2000-1 e 2005. O desfecho estudado foi o tabagismo, definido como consumo de pelo menos um cigarro na última semana nos acompanhamentos de 1997 e 2000-1. No acompanhamento de 2005, a variável dependente foi tabagismo atual. A análise ajustada foi realizada por meio de regressão de Poisson. RESULTADOS: As prevalências de tabagismo entre homens foram de 5,9%, 20,2% e 27,6% nos acompanhamentos de 1997, 2000-1 e 2005, respectivamente. Os respectivos valores para as mulheres foram 9,3%, 27,5% e 23,6%. A idade média de início do fumo foi de 15,1 anos (dp=2,5. Na análise multivariável, menor escolaridade materna, baixa renda familiar em 1982, ter sido pobre durante todo o período acompanhado e fumo materno na gravidez estiveram significativamente associados com maiores prevalências de fumo em ambos os sexos. A cor da pele não branca associou-se com maior risco de fumo apenas entre as mulheres. A amamentação não mostrou associação com tabagismo. Nas mulheres, o fumo esteve inversamente associado com o peso ao nascer na análise bruta, mas perdeu a significância na ajustada. CONCLUSÕES: A maior concentração de tabagismo nos grupos mais pobres sugere que condutas como o combate ao fumo na gestação e o aumento do preço do cigarro poderiam ter importante impacto populacional.OBJETIVO: Evaluar la prevalencia de tabaquismo en adolescentes y adultos jóvenes pertenecientes a una cohorte de nacimientos de base poblacional. MÉTODOS: Estudio prospectivo de cohorte de los nacidos en 1982 en la ciudad de Pelotas, RS, entrevistados en 1997, 2000-1 y 2005. El desenlace estudiado fue el tabaquismo, definido como consumo de al menos un cigarro en la última semana en los acompañamientos de 1997 y

  19. Uso de medicamentos do nascimento aos dois anos: Coorte de Nascimentos de Pelotas, RS, 2004 Uso de medicamentos desde el nacimiento hasta los dos años: Cohorte de Nacimientos de Pelotas, Sur de Brasil, 2004 Medicine use from birth to age two years: the 2004 Pelotas (Brazil Birth Cohort Study

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    Edilson Almeida de Oliveira

    2010-08-01

    Full Text Available OBJETIVO: Descrever a utilização de medicamentos em crianças aos três, 12 e 24 meses de idade. MÉTODOS: Estudo transversal utilizando dados da Coorte de Nascimentos de Pelotas, RS, de 2004. Foram incluídas 3.985 crianças aos três meses, 3.907 aos 12 meses e 3.868 aos 24 meses de idade. O desfecho considerado foi o uso de medicamentos pelas crianças nos 15 dias anteriores à entrevista. Informações sobre as variáveis independentes (medicamentos utilizados, fonte de indicação, forma de aquisição, regularidade do uso e grupos terapêuticos foram coletadas por meio de questionário padronizado, em entrevista aos pais nos domicílios. RESULTADOS: As prevalências de uso de medicamentos aos três, 12 e 24 meses foram de 65,0% (IC 95%: 63,5;66,5, 64,4% (IC 95%: 62,9;65,9 e 54,7% (IC 95%: 53,1;56,2, respectivamente. Com o avanço da idade observou-se diminuição no número total de medicamentos utilizados e aumento na automedicação, essa última chegando a 34% aos 24 meses. Também, a freqüência do uso de medicamentos em caráter eventual aumentou e diminuiu a de uso contínuo. Os medicamentos foram adquiridos principalmente com recursos próprios e cerca de 10% foi adquirido pelo Sistema Único de Saúde. Observou-se mudança no perfil dos grupos terapêuticos mais utilizados em função da idade. Aos três meses, o maior uso foi de medicamentos dermatológicos (36%; aos 12 meses, de medicamentos para o sistema respiratório (24%; e, aos 24 meses, de analgésicos (26%. Comparando-se o uso aos 24 meses com o dos três meses de idade observou-se diminuição na utilização de: medicamentos destinados ao trato alimentar e metabolismo, aos órgãos dos sentidos, sistema cardiovascular e produtos dermatológicos. Houve aumento na utilização de: medicamentos anti-infecciosos sistêmicos, destinados ao sistema musculoesquelético, ao sistema respiratório, analgésicos, antiparasitários, inseticidas e repelentes. CONCLUSÕES: A

  20. Prevalência de doação de sangue e fatores associados, Pelotas, RS Prevalencia de donación de sangre y factores asociados, Pelotas, Sur de Brasil Blood donation prevalence and associated factors in Pelotas, Southern Brazil

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    Alethea Zago

    2010-02-01

    Full Text Available OBJETIVO: Estimar a prevalência de doação de sangue e fatores associados. MÉTODOS: Estudo transversal com amostra representativa de 2.986 indivíduos com 20 anos ou mais realizado em Pelotas, RS, em 2007. Foram considerados três desfechos: doação de sangue alguma vez na vida, doação no último ano e doação fidelizada (pelo menos duas doações no último ano. Cada desfecho foi analisado de acordo com variáveis demográficas, socioeconômicas, de saúde, exposição a campanhas de promoção da doação de sangue e ter parente ou amigo doador. A análise bruta e multivariável foi feita utilizando-se regressão de Poisson, com ajuste para o efeito do desenho amostral. RESULTADOS: As prevalências encontradas de doação de sangue alguma vez na vida, no último ano e de doação fidelizada, foram, respectivamente, 32%, 7,7% e 3,6%. Tais prevalências foram maiores para indivíduos do sexo masculino e aumentou conforme o nível econômico e a autopercepção da saúde. A prevalência de doação na vida foi maior para o grupo etário de 50 a 65 anos; no último ano, foi maior entre os mais jovens (20 a 29 anos; e a doação fidelizada foi maior para o grupo de 30 a 49 anos. Cor da pele, situação conjugal, religião, ter parente ou amigo doador e conhecimento sobre campanhas não apresentaram associação com nenhum dos desfechos analisados. CONCLUSÕES: A prevalência de doação de sangue foi maior para os homens e para aqueles com melhor auto-percepção de saúde e nível econômico. As campanhas de incentivo à doação deveriam diversificar o perfil dos doadores, de modo a atingir os grupos de pessoas menos propensas a doar sangueOBJETIVO: Estimar la prevalencia de donación de sangre y factores asociados. MÉTODOS: Estudio transversal con muestra representativa de 2.986 individuos con 20 años o más realizado en la ciudad de Pelotas, Sur de Brasil, en 2007. Fueron considerados tres hechos: donación de sangre alguna vez en la

  1. Prevalência de Diabetes Mellitus em Pelotas, RS: um estudo de base populacional Prevalence of Diabetes Mellitus in Southern Brazil: a population-based study

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    Juvenal Soares Dias da Costa; Maria Teresa Anselmo Olinto; Maria Cecília Formoso Assunção; Denise Petrucci Gigante; Silvia Macedo; Ana Maria Baptista Menezes

    2006-01-01

    OBJETIVO: Comparar a prevalência de Diabetes Mellitus em população adulta, residente em área urbana, segundo auto-referência e valores de exame de glicemia de jejum. MÉTODOS: Realizou-se um estudo transversal de base populacional, com 1.968 pessoas de 20 a 69 anos, residentes na zona urbana da cidade de Pelotas, Estado do Rio Grande do Sul, em 2000. Estimou-se uma amostra de 1.800 indivíduos. Realizaram-se visitas domiciliares em 40 setores censitários sorteados aleatoriamente. Foi aplicado u...

  2. Exame citopatológico de colo uterino em mulheres com idade entre 20 e 59 anos em Pelotas, RS: prevalência, foco e fatores associados à sua não realização Pap smears of 20 - 59 year-old women in Pelotas, Southern Brazil: prevalence, approach and factors associated with not undergoing the test

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    Arnildo A. Hackenhaar

    2006-03-01

    Full Text Available OBJETIVO: Determinar a prevalência e o foco de realização do exame citopatológico do colo uterino e também fatores associados à sua não realização em mulheres com idade entre 20 e 59 anos residentes na cidade de Pelotas, RS. MÉTODOS: Entre outubro e dezembro de 2003 foi realizado um estudo transversal de base populacional. Através de amostragem por conglomerados foram sorteados 144 setores censitários em múltiplos estágios. Foram investigadas variáveis sociodemográficas e a realização de exame citopatológico do colo uterino. RESULTADOS: Dentre as 1404 mulheres que constituem a população-alvo dos programas de prevenção do câncer do colo uterino, 83,0% realizaram o exame citopatológico do colo uterino nos três anos antecedentes a este estudo. Mostraram-se significativamente associadas (POBJECTIVE: This study aims to determine the prevalence of and approach of Pap smear tests, as well as associated factors in women living in Pelotas, RS, Southern Brazil, within the 20 - 59 age range, who did not undergo a Pap smear. METHODS: A cross-sectional population-based study was carried out from October to December 2003. 144 census tracts were sampled through a multiple-stage clustered method. Socio-demographic variables were investigated, as well as women's Pap smear tests. RESULTS: Among the 1,404 women who were the target population included in the early detection program of uterine cervix cancer, 83% had had Pap smears in the three years before the study. Variables statistically associated (p<0.05 with women not undergoing the test in the previous three years were: ages ranging from 20-29 to 50-59 years compared with 40-49 year-old women, lower schooling level, lower social level, mixed and black skin color, not having seen a gynecologist in the previous 12 months. CONCLUSIONS: Although this study presents a high coverage of women undergoing Pap smears, women that present higher risk factors for this type of cancer had fewer

  3. Qualidade da dieta de jovens aos 18 anos de idade, pertencentes à coorte de nascimentos de 1993 da cidade de Pelotas (RS, Brasil

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    Cristina Bossle de Castilhos

    2015-11-01

    Full Text Available O objetivo deste artigo é descrever a qualidade da dieta de adolescentes segundo fatores sociodemográficos e comportamentais. Estudo transversal com 3.959 adolescentes de dezoito anos de idade, pertencentes à coorte de nascimentos de 1993, de Pelotas, Rio Grande do Sul, Brasil. O consumo alimentar foi avaliado através de um Questionário de Frequência Alimentar semiquantitativo, com período recordatório de 12 meses. A qualidade da dieta foi avaliada através do Índice de Qualidade da Dieta Revisado (IQD-R. Este índice varia de 0 a 100 pontos e quanto maior a pontuação, melhor a qualidade da dieta. A média geral do escore do IQD-R foi de 62,4 pontos (DP 12. Adolescentes com cor da pele não branca (63,1, provenientes de familias cujos chefes tinham menor escolaridade (63,6 e pertencentes ao menor quintil do índice de bens (64,7 apresentaram maiores médias no escore do IQD-R. Menores médias foram encontradas entre adolescentes que fumavam (58,5 e que consumiam bebida alcoólica (56,0. Este estudo mostrou que a qualidade da dieta dos adolescentes avaliados merece atenção, especialmente no que se refere à ingestão de vegetais, leites e derivados.

  4. Prevalência de Diabetes Mellitus em Pelotas, RS: um estudo de base populacional Prevalence of Diabetes Mellitus in Southern Brazil: a population-based study

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    Juvenal Soares Dias da Costa

    2006-06-01

    Full Text Available OBJETIVO: Comparar a prevalência de Diabetes Mellitus em população adulta, residente em área urbana, segundo auto-referência e valores de exame de glicemia de jejum. MÉTODOS: Realizou-se um estudo transversal de base populacional, com 1.968 pessoas de 20 a 69 anos, residentes na zona urbana da cidade de Pelotas, Estado do Rio Grande do Sul, em 2000. Estimou-se uma amostra de 1.800 indivíduos. Realizaram-se visitas domiciliares em 40 setores censitários sorteados aleatoriamente. Foi aplicado um questionário padronizado a todos participantes da pesquisa, incluindo perguntas sobre a presença de "açúcar no sangue", e quando afirmativo, se algum médico havia confirmado a doença. Uma subamostra de 367 participantes foi sorteada para realização de exames, entre os quais glicemia de jejum. Adotou-se como ponto de corte da glicemia de jejum para reconhecimento de diabetes 126 mg/dl e 140 mg/dl. Os resultados foram apresentados na forma de freqüência e respectivos intervalos de confiança de 95%. RESULTADOS: Dos entrevistados, 110 (5,6%; IC 95%: 4,6-6,6 referiram a presença de Diabetes Mellitus com diagnóstico confirmado pelo médico. Para as 367 pessoas submetidas aos exames laboratoriais, a prevalência de diabetes auto-referido e confirmada por médico foi de 7,1% (IC 95%: 4,5-9,7. CONCLUSÕES: As estimativas de prevalência encontradas são compatíveis com as obtidas em outras investigações nacionais. Os estudos epidemiológicos de base populacional são raros no Brasil e podem contribuir para o planejamento em saúde.OBJECTIVE: To compare the prevalence of Diabetes Mellitus among the adult population of an urban area, according to self-reported diabetes and fasting glucose test results. METHODS: We carried out a population-based cross-sectional study of 1,968 subjects aged 20-69 years, living in the urban area of the city of Pelotas, Southern Brazil, in the year 2000. Sample size was calculated at 1,800 subjects. We visited the

  5. Qualidade da dieta de pré-escolares de 2 a 5 anos residentes na área urbana da cidade de Pelotas, RS

    Directory of Open Access Journals (Sweden)

    Katharine Konrad Leal

    2015-09-01

    Full Text Available ResumoObjetivo:Avaliar a qualidade da dieta de pré-escolares residentes na área urbana da cidade de Pelotas, Rio Grande do Sul, Brasil.Métodos:A qualidade da dieta foi avaliada de acordo com o Índice de Alimentação Saudável (IAS, adaptado para o Brasil. O consumo alimentar foi medido por meio de Questionário de Frequência Alimentar. O escore do índice foi obtido por uma pontuação distribuída em 13 grupos alimentares, que caracterizam diferentes aspectos de uma dieta saudável, variação de 0 a 100 pontos. Quanto mais próximo de 100, melhor será a qualidade da dieta.Resultados:A qualidade da dieta foi avaliada em 556 pré-escolares. O valor médio do escore do IAS foi de 74,4 pontos. Isso indica que as dietas necessitam ser melhoradas. As médias dos escores foram significativamente maiores entre as meninas e entre crianças provenientes de famílias com renda familiar entre um e menos de três salários mínimos mensais.Conclusões:As crianças apresentaram consumo de verduras e legumes abaixo da recomendação, enquanto os alimentos do grupo dos óleos e gorduras, bem como do grupo dos açúcares, balas, chocolates e salgadinhos, foram consumidos em excesso. É importante reforçar orientações para promover um hábito alimentar mais saudável, que poderá perdurar em etapas posteriores da vida

  6. Nutrição materna e duração da amamentação em uma coorte de nascimento de Pelotas, RS

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    Gigante Denise Petrucci

    2000-01-01

    Full Text Available OBJETIVO: Os efeitos da situação nutricional materna sobre a duração da amamentação são inconsistentes na literatura. O estudo realizado objetivou investigar esses efeitos em uma coorte de nascimentos hospitalares. MÉTODOS: Foram estudadas 977 mulheres que tiveram filhos no ano de 1993, em Pelotas (representando 20% dos nascimentos ocorridos nesse ano. Os efeitos da situação nutricional materna e de variáveis socioeconômicas e demográficas sobre a prevalência de amamentação aos seis meses de idade e sobre a duração da amamentação foram analisados pela regressão logística e de Cox, respectivamente. RESULTADOS: A análise multivariada mostrou que a prevalência de amamentação foi mais alta entre mulheres que iniciaram a gestação com 49 kg ou mais (RO = 1,31; IC95% 1,04 - 1,64, e a associação com altura materna foi no limiar da significância (p=0,06. A regressão de Cox mostrou um efeito protetor, no limiar da significância, do maior peso pré-gestacional sobre o desmame (RR = 0,91; IC95% 0,82 -- 1,01. Não houve diferença na duração da amamentação quanto à altura materna. O ganho de peso gestacional não mostrou associação com prevalência ou duração da amamentação. Idade materna, paridade, hábito de tabagismo e idade gestacional estiveram associadas significativamente com a amamentação em ambas as análises. Renda familiar mostrou associação com a prevalência de amamentação aos seis meses e o peso ao nascer com a duração da amamentação. CONCLUSÕES: Peso pré-gestacional foi um melhor preditor para duração da amamentação do que o ganho de peso gestacional.

  7. Escherichia coli verotoxigênica: isolamento e prevalência em 60 propriedades de bovinos de leite da região de Pelotas, RS, Brasil Verotoxin-producing Escherichia coli: isolation and prevalence in 60 dairy cattle farms from Pelotas-RS, Brazil

    Directory of Open Access Journals (Sweden)

    Cecília Nunes Moreira Sandrini

    2007-02-01

    Full Text Available A produção de verotoxinas foi investigada em 1.127 isolamentos de Escherichia coli feitos a partir de 243 bovinos de leite, de água de consumo humano e animal e de amostras de leite de 60 propriedades da bacia leiteira de Pelotas, no período de dezembro de 1999 a dezembro de 2000, com o objetivo de determinar a prevalência de E. coli verotoxigênicas (VTEC nas propriedades e no rebanho, de detectar a presença de sorotipos ligados a infecções humanas e de identificar, nas propriedades e na região de Pelotas, potenciais fatores de risco de infecção para os animais. A detecção das toxinas em sobrenadante de culturas de E. coli isoladas foi realizada através do ensaio de citotoxicidade em células Vero. VTEC foi isolada em 95% (57/60 das propriedades estudadas, em 49% (119/243 dos animais testados, em 5% (3/60 das amostras de água de consumo humano, em 8,35% (5/60 das amostras de água de consumo animal e em 5% (3/60 das amostras de leite. A prevalência de bovinos infectados em cada propriedade variou de 0 a 100%. Em 2,9% (7/243 dos animais testados, foram isoladas VTEC pertencentes aos sorogrupos O157, O91 e O112, que incluem cepas responsáveis por casos de colite hemorrágica e síndrome urêmica hemolítica em humanos. Fatores de risco de contaminação, como a precipitação pluviométrica, a temperatura, o tamanho da propriedade e a concentração de animais, apresentaram evidências de influenciarem a prevalência de VTEC nos animais. Estes resultados sugerem que o grupo VTEC está amplamente distribuído na bacia leiteira de Pelotas e inclui organismos pertencentes a sorogrupos patogênicos para humanos.The production of verotoxin was investigated in 1127 Escherichia coli isolated from 243 dairy cattle, water for human and animal consumption, and milk samples from 60 dairy farms from Pelotas-Brazil, from December of 1999 to December of 2000, to determine the prevalence of verotoxigenic E. coli (VTEC in farms, to detect the

  8. Alterações Geomorfológicas Derivadas Da Intervenção De Atividades Antrópicas: análise temporal na Bacia do Arroio Santa Bárbara – Pelotas (RS.

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    Adriano Luís Heck Simon

    2010-08-01

    Full Text Available A análise temporal das alterações nas formas do relevo, tendo como base informações espaciais oriundas da cartografia geomorfológica, possibilita a compreensão da gênese dos distúrbios na morfodinâmica e dos impactos ambientais. Assim, este artigo foi desenvolvido com o objetivo de analisar as principais alterações geomorfológicas desencadeadas na bacia do Arroio Santa Bárbara, localizada no município de PelotasRS, durante 41 anos (1965 – 2006. Para avaliar as alterações ocorridas sobre a morfologia, foram elaborados mapas geomorfológicos da área em estudo, referentes aos anos de 1965 e 1995, a partir da interpretação de fotografias aéreas. O cenário de 2006 foi constituído por meio de representações cartográficas, esquematizadas a partir da obtenção de imagens orbitais do software Google Earth TM. A integralização deste mapeamento ocorreu por meio de trabalhos de campo, onde foram constatadas as transformações da morfologia e as feições geomorfológicas artificiais. As atividades antrópicas efetivaram a imposição de mecanismos de controle que alteraram as formas e a estrutura do sistema, agindo, conseqüentemente, sobre os fluxos de matéria e energia. Tais alterações vinculam-se à expansão urbana, ao desenvolvimento das atividades agrícolas e às ações antrópicas pontuais como a mineração e a interceptação dos cursos de água para a construção de reservatórios.

  9. Produção integrada de pêssegos: três anos de experiência na região de Pelotas - RS Integrated production of peaches: 3 years of experience in the area of Pelotas, Rio Grande do Sul state, Brasil

    Directory of Open Access Journals (Sweden)

    José Carlos Fachinello

    2003-08-01

    Full Text Available O objetivo do trabalho foi avaliar agronomicamente o sistema de produção integrada (PI x produção convencional (PC em pomar de pessegueiro cv. Diamante, no município de Pelotas - RS, comparando-se dados de três anos de avaliação (1999 - 2001, em duas áreas distintas. Os sistemas de produção caracterizaram-se: PC no qual prevalece o manejo e práticas culturais utilizadas normalmente pelo produtor e PI no qual são utilizadas as práticas de manejo definidas nas "Normas para Produção Integrada de Pêssego". As avaliações compreenderam: produção total, classificação dos frutos, danos, análises pós-colheita e resíduos de agrotóxicos. Pela análise da produção por planta e número de frutas produzidas por planta, pode-se verificar que a produção foi maior na PI. Pela avaliação da qualidade das frutas, verificou-se que houve aumento no número de frutas na categoria I, no sistema PI. A ocorrência de danos na colheita por insetos, doenças, pássaros e, muitas vezes, pela interação destes foi maior no sistema PC. Pela análise de agrotóxicos na polpa das frutas, não foram encontrados resíduos nas mesmas, dentro dos limites máximos estabelecidos. As frutas do sistema PI apresentaram, na colheita, maiores firmeza da polpa e teor de acidez, e menor teor de sólidos solúveis totais.The objective of this work was to evaluate agronomically the system of integrated production (IP x conventional production (CP in orchard of peach tree cv. Diamante in the rural area of Pelotas, Rio Grande do Sul State, Brazil. The study was conducted during three years (1999- 2001, in two different areas. The production systems were characterized as: in the CP prevails the handling and cultural practices usually used by the producer and IP is where the defined handling practices are used in the "Norms for Integrated Peach Production". The evaluations were: total production, classification of the fruits, damages, analyses post-harvesting and

  10. Critérios de escolha de postos de saúde para acompanhamento pré-natal em Pelotas, RS Criteria for choosing primary health care facilities for prenatal care, Brazil

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    Iná S Santos

    2000-12-01

    Full Text Available OBJETIVO: Caracterizar o cuidado pré-natal em uma amostra representativa de mães, identificando o serviço de saúde onde estas realizaram o acompanhamento da gestação e os motivos que as levaram a escolher este local. MÉTODOS: Estudo transversal, realizado nos meses de março e abril de 1997, nas quatro principais maternidades de Pelotas, RS, através de entrevista a 401 mães no pós-parto imediato. RESULTADOS: Fizeram acompanhamento pré-natal, em um posto de saúde 51% das mães, sendo a proximidade geográfica o critério mais freqüentemente referido para tal escolha (46,8%. Para 85% das mães, o serviço de saúde mais próximo de casa era um posto de saúde. No entanto, 52,2% dessas não utilizaram esse local para as consultas pré-natais alegando a má qualidade do atendimento (37,4%. Conforme referido pelas mães, entre os procedimentos de rotina do pré-natal recomendados pelo programa de saúde da rede pública, incluindo a promoção do aleitamento materno, apenas a imunização anti-tetânica foi realizada mais freqüentemente nos postos do que nos demais locais. CONCLUSÕES: Tendo em vista a expressiva utilização da rede pública para o acompanhamento pré-natal, necessitam ser implementados investimentos em educação continuada dos profissionais, com ênfase no cumprimento de normas técnicas pré-estabelecidas.OBJECTIVE: To describe the prenatal care delivered to a representative sample of mothers, identifying the health care facility they attended and to explore the reasons that led them to choose that specific health facility. METHOD: A cross-sectional study was conducted at four maternity hospitals in Pelotas, in Southern Brazil, from March to April 1997. A total of 401 mothers were interviewed at the hospital, immediately after delivery. RESULTS: The majority of mothers (51% were followed up at a primary health care facility (PHCF. The main reported reason for choosing a PHCF was its geographic accessibility (46

  11. Padrões de sibilância respiratória do nascimento até o início da adolescência: coorte de Pelotas (RS Brasil, 1993-2004 Wheezing phenotypes from birth to adolescence: a cohort study in Pelotas, Brazil, 1993-2004

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    Adriana Muiño

    2008-06-01

    Full Text Available OBJETIVO: Estudar a prevalência dos padrões de sibilância respiratória e suas associações com variáveis independentes. MÉTODOS: Coorte de nascidos vivos, 1993, Pelotas (RS; subamostra sistemática de 20% da coorte original acompanhada aos 6 e 12 meses e 4 anos; aos 10-12 anos localizou-se 87,5% da coorte original. Definição dos padrões: transitório: chiado até 4 anos e ausência de chiado aos 10-12 anos; persistente: chiado em todos acompanhamentos; início tardio: chiado aos 10-12 anos. Variáveis independentes: gênero; cor da pele; renda familiar; fumo/asma na gravidez; amamentação; infecção respiratória/diarréia (1º ano; alergia e asma na família (4 e 10-12 anos; diagnóstico médico de rinite/eczema (10-12 anos. RESULTADOS: O total da subamostra foi de 897 adolescentes. Prevalência (IC95% dos padrões de sibilância: transitório 43,9% (40,7-47,2;persistente 6,4% (4,8-8,0; de início tardio 3,3% (2,2-4,5. O transitório foi mais freqüente em crianças de famílias de baixa renda, com menor duração da amamentação, relato de infecções respiratórias (1º ano e história familiar de asma (4 anos; o persistente foi quase duas vezes mais freqüente em meninos, em filhos de mulheres com asma na gravidez, com infecções respiratórias (1º ano e história familiar de asma (4 e 10-12 anos; de início tardio mostrou maior prevalência naqueles com asma na família (10-12 anos e diagnóstico médico de rinite (10-12 anos; menor prevalência em quem relatou infecções respiratórias (1º ano e diagnóstico médico de eczema (10-12 anos. CONCLUSÕES: O conhecimento das associações dos padrões sibilantes permite a adoção de medidas preventivas e terapêuticas.OBJECTIVE: To study the prevalence of wheezing patterns and their associations with independent variables. METHODS: Cohort study of live births in 1993 in Pelotas, Brazil. A systematic subsample (20% of the original cohort was evaluated at 6 months, 12 months and

  12. Depressão pós-parto e alterações de sono aos 12 meses em bebês nascidos na zona urbana da cidade de Pelotas/RS Postpartum depression and sleep disorders in 12 month-old babies born in the urban area of Pelotas city

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    Eliane Rozales Lopes

    2010-01-01

    Full Text Available OBJETIVO: Verificar se existe associação entre as alterações no sono dos bebês aos 12 meses de vida e a depressão pós-parto materna. MÉTODOS: Estudo do tipo transversal aninhado a uma coorte. A amostra foi constituída por mulheres que realizaram o acompanhamento pelo Sistema Único de Saúde (SUS, nas unidades básicas de saúde do município de Pelotas, e que tiveram seus partos a partir de junho/2006. Os bebês de 12 meses oriundos dessa gestação também fazem parte da amostra. Para avaliar a presença de sintomas depressivos nas mães, foi utilizada a Edinburgh Postnatal Depression Scale (EPDS e foram investigados os seguintes comportamentos do sono dos bebês: horas de sono por dia, regularidade do horário para dormir e acordar, sono agitado e despertar noturno. Para análise, foi utilizada Regressão de Poisson. RESULTADOS: 35,7% dos bebês possuem alteração no padrão de sono. Após o ajuste ao modelo hierárquico proposto, a alteração no sono infantil manteve associação com a sintomatologia depressiva da mãe (p OBJECTIVE: Verify whether there is association between sleep disorders in babies at 12 months of age and postpartum depression in motherhood. METHODS:Cross sectional study. The sample was made up of women who had done their prenatal medical care at the National Health System (SUS, at the health basic units in Pelotas and who had their deliveries from June, 2006. The 12 month old babies from these women are also part of the sample. In order to assess depressive symptoms in the mothers, Edinburgh Postnatal Depression Scale was used and the following sleeping behaviors of the babies were investigated: hours of sleep per day, regularity of sleep and wake up time, disturbed sleep and night awakening. Poisson Regression was used for the analysis. RESULTS: 35.7% of the babies showed alterations in their sleeping patterns. After adjusting for the proposed hierarchal model, sleep alteration of the babies was still

  13. Abastecendo plantations: A inserção do charque fabricado em Pelotas (RS no comércio atlântico das carnes e a sua concorrência com os produtores platinos (século XIX

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    Jonas Moreira VARGAS

    2014-12-01

    Full Text Available O charque (carne-seca constituiu alimento fundamental na dieta dos escravos das plantations açucareiras e cafeeiras e das populações pobres das cidades litorâneas do Brasil. O artigo analisa a inserção do charque fabricado em Pelotas (Rio Grande do Sul no mercado atlântico, assim como a concorrência com os produtores uruguaios e argentinos e como as guerras travadas na região da fronteira sul afetaram o comércio da mercadoria. Durante a segunda metade do século XIX, a carne-seca rio-grandense foi perdendo espaço no comércio atlântico para o produto platino, mais saboroso e de preço mais acessível. Na busca de novos mercados consumidores para além do Brasil e de Cuba, tanto os rio-grandenses quanto os produtores do Rio da Prata não conseguiram penetrar no mercado britânico, em que o paladar era mais exigente e se associava o charque à comida de escravos. Com o tempo, os argentinos conseguiram modernizar sua indústria com remessa de carne congelada para a Europa, ao passo que os rio-grandenses sucumbiram diante dessa nova concorrência e das exigências dos consumidores, não resistindo à derradeira crise que afetou o setor na década de 1880.

  14. Methodological aspects of the 1993 Pelotas (Brazil) Birth Cohort Study

    Science.gov (United States)

    Victora, Cesar Gomes; Araújo, Cora Luiza Pavin; Menezes, Ana Maria Batista; Hallal, Pedro Curi; Vieira, Maria de Fátima; Neutzling, Marilda Borges; Gonçalves, Helen; Valle, Neiva Cristina; Lima, Rosangela Costa; Anselmi, Luciana; Behague, Dominique; Gigante, Denise Petrucci; Barros, Fernando Celso

    2010-01-01

    This paper describes the main methodological aspects of a cohort study, with emphasis on its recent phases, which may be relevant to investigators planning to carry out similar studies. In 1993, a population based study was launched in Pelotas, Southern Brazil. All 5,249 newborns delivered in the city’s hospitals were enrolled, and sub-samples were visited at the ages of one, three and six months and of one and four years. In 2004-5 it was possible to trace 87.5% of the cohort at the age of 10-12 years. Sub-studies are addressing issues related to oral health, psychological development and mental health, body composition, and ethnography. Birth cohort studies are essential for investigating the early determinants of adult disease and nutritional status, yet few such studies are available from low and middle-income countries where these determinants may differ from those documented in more developed settings. PMID:16410981

  15. Typographic Landscapes of Pelotas: initial survey of the collection and some methodological definitions

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    Daniela Velleda Brisolara

    2016-03-01

    Full Text Available This paper presents part of the research “Pelotas Typographic Landscapes: An exploratory study of the typography in the urban space”. The study aims to investigate the different occurrences of typographic landscapes in certain urban areas of the city of Pelotas / RS to better understanding of typography as a historical and cultural information. The research is based on studies of ‘typographic landscapes’ that have been developed in recent years in several Brazilian cities, which presents methods for collecting, processing and analysis of typography data in the urban space. Therefore, the methodology adopted is based on the indications of investigative process already started in this field, such as the establishment of routes and field research records, making adaptations necessary to context. This paper presents samples of survey from two typographical categories performed in a specific region, in addition to the proposed adjustment to the structure of cataloguing and analysis record.

  16. Strontium isotope stratigraphy of the Pelotas Basin

    Energy Technology Data Exchange (ETDEWEB)

    Zerfass, Geise de Santana dos Anjos, E-mail: geise.zerfass@petrobras.com.br [Petroleo Brasileiro S.A. (PETROBRAS/CENPES/PDGEO/BPA), Rio de Janeiro, RJ (Brazil). Centro de Pesquisas e Desenvolvimento Leopoldo Americo Miguez de Mello; Chemale Junior, Farid, E-mail: fchemale@unb.br [Universidade de Brasilia (UnB), DF (Brazil). Instituto de Geociencias; Moura, Candido Augusto Veloso, E-mail: candido@ufpa.br [Universidade Federal do Para (UFPA), Belem, PA (Brazil). Centro de Geociencias. Dept. de Geoquimica e Petrologia; Costa, Karen Badaraco, E-mail: karen.costa@usp.br [Instituto Oceanografico, Sao Paulo, SP (Brazil); Kawashita, Koji, E-mail: koji@usp.br [Unversidade de Sao Paulo (USP), SP (Brazil). Centro de Pesquisas Geocronologicas

    2014-07-01

    Strontium isotope data were obtained from foraminifera shells of the Pelotas Basin Tertiary deposits to facilitate the refinement of the chronostratigraphic framework of this section. This represents the first approach to the acquisition of numerical ages for these strata. Strontium isotope stratigraphy allowed the identification of eight depositional hiatuses in the Eocene-Pliocene section, here classified as disconformities and a condensed section. The reconnaissance of depositional gaps based on confident age assignments represents an important advance considering the remarkably low chronostratigraphic resolution in the Cenozoic section of the Pelotas Basin. The recognition of hiatuses that match hiatuses is based on biostratigraphic data, as well as on global events. Furthermore, a substantial increase in the sedimentation rate of the upper Miocene section was identified. Paleotemperature and productivity trends were identified based on oxygen and carbon isotope data from the Oligocene-Miocene section, which are coherent with worldwide events, indicating the environmental conditions during sedimentation. (author)

  17. Strontium isotope stratigraphy of the Pelotas Basin

    International Nuclear Information System (INIS)

    Strontium isotope data were obtained from foraminifera shells of the Pelotas Basin Tertiary deposits to facilitate the refinement of the chronostratigraphic framework of this section. This represents the first approach to the acquisition of numerical ages for these strata. Strontium isotope stratigraphy allowed the identification of eight depositional hiatuses in the Eocene-Pliocene section, here classified as disconformities and a condensed section. The reconnaissance of depositional gaps based on confident age assignments represents an important advance considering the remarkably low chronostratigraphic resolution in the Cenozoic section of the Pelotas Basin. The recognition of hiatuses that match hiatuses is based on biostratigraphic data, as well as on global events. Furthermore, a substantial increase in the sedimentation rate of the upper Miocene section was identified. Paleotemperature and productivity trends were identified based on oxygen and carbon isotope data from the Oligocene-Miocene section, which are coherent with worldwide events, indicating the environmental conditions during sedimentation. (author)

  18. Demo 16. Colisión pelota de baloncesto-pelota de tenis

    OpenAIRE

    Ferrer Roca, Chantal; Coll Company, César

    2013-01-01

    Objetivo: La pelota de tenis rebota hasta una altura superior a aquella desde la que fue lanzada cuando lo hace rebotando sobre la de baloncesto (no así cuando rebota en el suelo). Este fenómeno se explica apelando a la conservación de momento y energía mecánica.

  19. Prevalência de nascimentos gemelares em Pelotas, Rio Grande do Sul, Brasil Prevalence of twin births in Pelotas, in the State of Rio Grande do Sul, Brazil

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    Cesar Fernando Geraldo

    2008-12-01

    Full Text Available OBJETIVOS: avaliar a prevalência de nascimentos gemelares em Pelotas, RS, em três períodos da última década e a influência de alguns fatores sobre este processo. MÉTODOS: estudo de corte transversal (série temporal, baseado no banco de dados do Programa de Monitorização de Defeitos Congênitos, onde se encontram registrados todos os nascimentos ocorridos nos cinco hospitais da cidade de Pelotas, nos anos de 1993, 1997 e 2003. RESULTADOS: a taxa média de gêmeos por mil nascimentos foi de 8,95‰ (monozigóticos=2,20‰ e dizigóticos=6,76‰ . A taxa de triplos ficou em 0,07‰ . A taxa total de nascimentos gemelares, assim como de gêmeos monozigóticos e dizigóticos sofreu elevação no período. A média de idade (27,53 anos e da ordem gestacional (2,35 das mães de gêmeos foi significativamente mais elevada do que das mães de únicos (26,03 anos e 2,14 respectivamente. Verificaram-se números aproximados de partos gemelares e únicos nos diferentes grupos de renda materna analisados. CONCLUSÕES: as mães com idade maior ou igual a 30 anos foram responsáveis pelo aumento da taxa de gêmeos em Pelotas. A média mais elevada de ordem gestacional em mães de gemelares descartou o uso significativo de técnicas de reprodução assistida.OBJECTIVES: to evaluate the prevalence of twin births in Pelotas, Rio Grande do Sul, Brazil, during three periods, and the influence of a number of factors on this occurrence. METHODS: a cross-cutting (multiple time series study was carried out, using the database of the Congenital Defect Monitoring Program, which registers all of the births occurring in the five hospitals of the city of Pelotas, for the years 1993, 1997 and 2003. RESULTS: the mean prevalence of twin births per thousand births (‰ t was 8.95‰ (monozygotic=2.20‰ and dizygotic=6.76‰ . The prevalence of triplets was 0.07‰ . The total prevalence for twin births, in the case of both monozygotic and dizygotic twins rose over the period

  20. Alimentação nos primeiros três meses de vida dos bebês de uma coorte na cidade de Pelotas, Rio Grande do Sul Alimentación en los primeros tres meses de vida de los bebés de una coorte en la ciudad de Pelotas, Rio Grande do Sul (Brasil Feeding during the first three months of life for infants of a cohort in Pelotas, Rio Grande do Sul, Brazil

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    Cristina Corrêa Kaufmann

    2012-06-01

    Full Text Available OBJETIVO: Estudar o padrão alimentar nos primeiros três meses de vida de crianças nascidas na cidade de Pelotas (RS. MÉTODOS: Estudo de coorte prospectivo com os bebês nascidos entre setembro de 2002 e maio de 2003, na cidade de Pelotas (RS. Incluíram-se 2.741 bebês nas maternidades e uma amostra aleatória de 30% acompanhada no primeiro e terceiro meses de vida. Foram realizadas análises uni, bi e multivariada. Somente as variáveis com pOBJETIVO: Estudiar el estándar alimentar en los primeros tres meses de vida de niños nascidos en la ciudad de Pelotas (RS, Brasil. MÉTODOS: Estudio de coorte prospectivo con bebés nascidos entre septiembre de 2002 y mayo de 2003, en la ciudad de Pelotas (RS, Brasil. Se incluyó a 2.741 bebés en las maternidades y una muestra aleatoria de 30%, seguida en el primero y el tercero meses de vida. Se realizaron análisis uni, bi y multivariados, y solamente las variables con pOBJECTIVE: To study the feeding pattern in the first three months of babies born in the Pelotas city, in Sothern Brazil. METHODS: Prospective cohort study, with babies born between september 2002 and may 2003. Among 2,741 babies whose mothers were interviewed at the maternity ward, a random sample of 30% was followed up on the first and third months of age. Univariate, bivariate and multivariate analyses were applied. Variables with a p<0.05 were considered as associated. RESULTS: 951 babies were followed up on the first month, 60% were under exclusive maternal breastfeeding, and 10% were already weaned. Smoking during pregnancy, father's educational level lower than four years and the use of a pacifier were associated to weaning. On the third month, 29% had been weaned, 39% received maternal milk exclusively, and 59% were bottle fed. Smoking during pregnancy, father schooling and the use of a pacifier were associated with weaning. There was an increase in the pacifier use - from 56 to 66% between the first and the third month of

  1. Phytosociology of a coastal peat forest of the Toto Beach, Municipality of Pelotas, RS, Brazil

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    Tiago Schuch Lemos Venzke

    2015-06-01

    Full Text Available Floristic composition and structure of the tree component were analyzed in a coastal peat forest of the Toto Beach, located in the southern region of Lagoa dos Patos (31º43’39”S e 52º12’04”W. The phytosociological sampling was conducted on a sample area of 0.1 ha. All trees with DBH ≥ 4.8 cm were included. The species richness found was equivalent to 23 species distributed in 20 genera and 15 families. Two endangered species were sampled. The total tree density estimated for one hectare was equivalent to 3,480 trees. The most important species in the forest structure were Ocotea sp., Myrcia multiflora, Psidium cattleyanum, Ocotea pulchella, Myrsine lorentziana, Citharexyllum myrianthum, Ilex dumosa, Syagrus romanzoffiana, Guapira opposita and Sebastiania brasiliensis. The species diversity estimated by the Shannon index was 2,174 nats.ind.-1 and evenness (J was 0.684. The forest structure, number of taxa and diversity are similar to other surveys carried out in swamp forests of southern and southeastern Brazil. These parameters must be considered in the environmental licensing and ecological restoration projects of this forest type.

  2. Sporothrix schenckii in a hospital and home environment in the city of Pelotas/RS - Brazil

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    Antonella S. Mattei

    2011-12-01

    Full Text Available This study describes the isolation of S. schenckii in hospital and home environments in Brazil. Samples were collected from surfaces of a veterinary service place and at home. S. schenckii was detected in 1.5% of the samples from the hospital environment. However, this fungus was isolated from all sampled areas in home environments. The isolation of S. schenckii deonstrates that these surfaces could act as infection sources to anials and huans. Therefore, employees and pet owners could be exposed to this agent, and the contamination, through surfaces, could occur through the traumatic inoculation of the fungus or by direct contact with pre-existing lesions.Esse estudo descreve o isolamento de S. schenckii em ambiente hospitalar e domiciliar, no Brasil. Foram colhidas amostras de superfície de local de atendimento veterinário e ambiente domiciliar. S. schenckii foi isolado em 1,5% das amostras do ambiente hospitalar. Entretanto, esse fungo foi isolado em todas as amostras do ambiente domiciliar. O isolamento do S. schenckii demonstra a importância dessas superfícies atuarem como fontes de infecção para animais e humanos. Portanto, funcionários e proprietários de animais de estimação estariam expostos a esse agente e a contaminação, através das superfícies, poderia ocorrer pela inoculação traumática do fungo ou pelo contato direto com lesões pré-existentes.

  3. FUNGI ISOLATED FROM THE EXCRETA OF WILD BIRDS IN SCREENING CENTERS IN PELOTAS, RS, BRAZIL

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    Josiara Furtado Mendes

    2014-12-01

    Full Text Available The identification of the fungal species belonging to the healthy microflora in animals is a precondition for the recognition of pathological processes causing them. The aim of this study was to investigate the presence of potentially pathogenic fungi in the feces of wild birds collected in Screening Centers. Samples were collected from the feces of 50 cages with different species of birds. The samples were processed according to the modified method STAIB and the plates incubated at 32 °C for up to ten days with daily observation for detection of fungal growth. The isolation of the following species was observed: Malassezia pachydermatis, Candida albicans, C. famata, C. guilliermondii, C. sphaerica, C. globosa, C. catenulata, C. ciferri, C. intermedia, Cryptococcus laurentii, Trichosporon asahii, Geotrichum klebahnii, Aspergillus spp., A. niger and Penicillium spp. Knowing the character of some opportunistic fungi is important in identifying them, facilitating the adoption of preventive measures, such as proper cleaning of cages, since the accumulation of excreta may indicate a risk for both health professionals and centers for screening public health.

  4. Atenção pré-natal em Pelotas, Rio Grande do Sul, Brasil, 1993

    OpenAIRE

    Ricardo Halpern; Barros, Fernando C; Cesar G Victora; Elaine Tomasi

    1998-01-01

    Todos os 5304 nascimentos ocorridos nos hospitais de Pelotas, RS, em 1993, foram estudados. As crianças foram examinadas e suas mães entrevistadas através de um questionário estruturado, onde foram levantadas informações sobre condições demográficas, sócio-econômicas, história reprodutiva e assistência pré-natal. Quase a totalidade das mulheres (95%) realizou acompanhamento durante a gestação. O número médio de consultas foi de 7 e a maioria das mulheres (85%) iniciou o pré-natal antes do qui...

  5. Maria - RS

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    Suzinara Beatriz Soares de Lima

    2005-01-01

    Full Text Available Estudio de carácter histórico social que tiene como objetivo describir la memoria del servicio de enfermaria del Hospital Universitário de Santa Maria, en la Universidade Federal de Santa Maria – RS, durante el periodo de 1459 al 2000. Las fuentes primarias fueron documentos escritos y declaraciones orales de enfermeras que hacieron parte de esta trayectoria, y como fuentes secundarias se utilizaron los artículos y libros sobre el temática. Los resultados demuestran que el hospital, desde su fundación sufrió varias alteraciones en función de su misión y de las condiciones contextuales de trabajo. Fueron muchos los problemas administrativos enfrentados por los profisionales de enfermería. A razón de los hallazgos fue evidente el hecho de que la discusión de la racionalidad asistencial, las condiciones de trabajo y la posible autonomía profesional representan un avance importante para la comprensión del presente y la proyección del futuro servicio de enfermería del Hospital.

  6. Monitoramento da ação genotóxica em trabalhadores de sapatarias através do teste de micronúcleos, Pelotas, Rio Grande do Sul Monitoring the genotoxic action in shoe workers by micronucleus test, Pelotas, Rio Grande do Sul State

    OpenAIRE

    Natália Silveira Corrêa; Josiana Scherer Bassan; Cristiane de Jesus da Cunha; Ricardo Ramires Fernández; Paula Siqueira Bachettini; Gilberto de Lima Garcias; Maria da Graça Martino-Roth

    2009-01-01

    Neste trabalho, investigou-se a frequência de micronúcleos em células esfoliadas da mucosa bucal de trabalhadores de sapatarias, na cidade de Pelotas (RS). O estudo constou de 54 trabalhadores de sapatarias expostos à cola e solventes e 54 controles. Avaliou-se a incidência de células com micronúcleos(CMN), binucleadas(CBN), núcleos ligados(CNL) e total de anomalias(TA), em 2.000 células por indivíduo. Elaborou-se um banco de dados no programa SPSS "for Windows" pelo teste de Mann-Whitney U, ...

  7. Produção de cultivares de morango, utilizando túnel baixo em Pelotas

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    Roberto Pedroso de Oliveira

    2011-10-01

    Full Text Available O objetivo deste trabalho foi avaliar o desempenho produtivo de novos cultivares de dia-curto de morangueiro ('Earlibrite', 'Sabrosa' e 'Florida Festival', nas condições edafo-climáticas de Pelotas (RS, tendo como padrão o cultivar 'Camarosa', usando-se túnel baixo. O experimento foi realizado com sistema de irrigação por gotejamento. O transplantio das mudas foi realizado em maio de 2008, sendo utilizadas mudas procedentes da região da Patagônia, na Argentina. O delineamento experimental foi de blocos casualizados, com parcelas subdivididas no tempo, com quatro repetições. As unidades experimentais foram constituídas por 42 plantas, que foram avaliadas, semanalmente, quanto ao número, massa da matéria fresca e produção de frutos, no período de agosto a dezembro de 2008. Nas avaliações, consideraram-se apenas os frutos comercializáveis, descartando-se aqueles com defeitos e com massa inferior a 5 g. Verificou-se que a produção acumulada de frutos por planta do 'Sabrosa' é maior que a do 'Florida Festival' e do 'Earlibrite', menor, porém, que a do 'Camarosa'. O número de frutos produzidos por planta do 'Sabrosa' e do 'Florida Festival' é maior que o do 'Earlibrite', menor, porém, que o do 'Camarosa'. Quanto à produção de massa da matéria fresca média dos frutos, o 'Sabrosa' e o 'Camarosa' são superiores a do 'Florida Festival' e a do'Earlibrite'. Apesar de apresentarem padrões de desempenho produtivo diferenciados, os três novos cultivares de morangueiro testados mostraram-se com alto potencial produtivo, constituindo-se em interessantes alternativas de produção para os agricultores de Pelotas.

  8. Atenção pré-natal em Pelotas, Rio Grande do Sul, Brasil, 1993 Prenatal care in Pelotas, Rio Grande do Sul, Brazil, 1993

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    Ricardo Halpern

    1998-07-01

    Full Text Available Todos os 5304 nascimentos ocorridos nos hospitais de Pelotas, RS, em 1993, foram estudados. As crianças foram examinadas e suas mães entrevistadas através de um questionário estruturado, onde foram levantadas informações sobre condições demográficas, sócio-econômicas, história reprodutiva e assistência pré-natal. Quase a totalidade das mulheres (95% realizou acompanhamento durante a gestação. O número médio de consultas foi de 7 e a maioria das mulheres (85% iniciou o pré-natal antes do quinto mês de gestação. A ausência ao pré-natal foi maior entre as mulheres mais pobres, na maioria adolescentes ou com idade acima de 40 anos. A incidência de baixo peso ao nascer, no grupo que não fez pré-natal, foi de 2,5 vezes maior comparado com as mães que realizaram cinco ou mais consultas. Da mesma forma o coeficiente de mortalidade perinatal foi três vezes maior (50,6/1000 entre as mães que não realizaram pré-natal e aquelas que consultaram 5 ou mais vezes (15,8/1000. Em relação ao risco gestacional que as mães apresentavam, o estudo mostrou uma inversão nos cuidados, já que um quarto das mulheres de alto risco receberam uma atenção pré-natal considerada adequada, enquanto esta proporção era menos de 10% nas mães de risco gestacional mais baixo. Este estudo sugere a necessidade de modificações no atendimento pré-natal, com estratégias bem definidas para aquelas pacientes com alto risco gestacional.All 5304 births in the hospitals of Pelotas, Rio Grande do Sul, Brazil in 1993 were studied. Neonates were examined and their mothers were interviewed regarding sociodemographic conditions, family income, reproductive health, and medical care during pregnancy. Ninety-five per cent of women received prenatal care. The mean number of physician visits during pregnancy was 7 and the majority of the women (84.7% began visits before the fifth month of pregnancy. Women who did not receive prenatal care were from the

  9. Efecto del Cambio de Reglas en Pelota Vasca Escolar

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    Oidui Usabiaga Arruabarrena

    2014-01-01

    Full Text Available El objetivo del presente estudio fue analizar la influencia de las modificaciones de reglas en la acción de juego de los escolares que participaron en un programa de deporte escolar de pelota a mano. La muestra estuvo compuesta por 60 escolares de 8 a 12 años, 35 participaron en seis partidos celebrados durante el curso 2007-08 y los 25 restantes en otros seis enfrentamientos del 2008- 09. El registro se llevó a cabo mediante un instrumento observacional ad hoc y posteriormente se realizó un análisis de las variables: zona y tipo de golpe, ubicación espacial en situación de espera y dirección del saque, resto y juego de intercambio. La comparación (curso 2007-08 y 2008-09 de medias se llevó a cabo mediante el test no paramétrico de U de Mann-Whitney (p < 0,05, con corrección de Bonferroni. Los resultados muestran que, después de modificar las reglas, los jugadores de ambos cursos juegan de forma similar: golpean la pelota con la mano derecha en zonas próximas a la pared frontal e izquierda, se ubican a la derecha del jugador que golpea en los duelos por parejas y a la izquierda en los individuales, dirigen los saques a media distancia, cometen faltas en el resto y juego de intercambio y desarrollan un juego a corta distancia. La única diferencia se encontró en el resto a distancia corta y a la derecha. El análisis de indicadores de juego puede ser de gran ayuda para conocer los efectos de los cambios de reglas en el ámbito formativo.

  10. Campylobacter jejuni occurrence in chicken fecal samples from small properties in Pelotas, southern of Brazil Ocorrência de Campylobacter jejuni em amostras fecais de galinhas em pequenas propriedades de Pelotas, sul do Brasil

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    Fabiane R. Gomes

    2006-09-01

    Full Text Available The aim of this study was to evaluate the occurrence of thermophilic Campylobacter species in broiler flocks from 26 small properties located near the campus of Federal University of Pelotas, RS, Brazil. A total of 404 chicken fecal samples were analyzed and after isolation, identification and biotyping was performed according to Lior´s scheme. Twenty one strains (5.2% of Campylobacter jejuni biotype II were isolated from animals from seven properties (26.9%, with a variation from 3% to 34.6% among the positive properties. We also analyzed twelve C. jejuni isolates by polymerase chain reaction (PCR, using specific primers that generate a fragment of 402 pb. Our study allowed us to observe that chickens raised in non-industrial establishments without sanitary attention can harbour C. jejuni in their intestinal tract, and by doing so, they could be a serious health risk to humans.O objetivo deste estudo foi avaliar a ocorrência de espécies termofílicas de Campylobacter em galinhas de 26 pequenas propriedades localizadas próximo ao campus da Universidade Federal de Pelotas, RS, Brasil. Um total de 404 amostras fecais de galinhas foram analisadas e após o isolamento, a identificação e a biotipificação foram realizadas de acordo com o esquema de Lior. Vinte e uma amostras (5,2% de Campylobacter jejuni biotipo II foram isoladas de animais de sete propriedades (26,9%, com uma variação de 3,3% a 34,6% entre as propriedades positivas. Primers específicos, que geram um fragmento de 402pb, foram usados em PCR para analisar 12 isolados de C. jejuni. Concluímos que galinhas criadas em estabelecimentos não industriais e sem atenção sanitária, são portadoras de C. jejuni e, desta forma, podem ser consideradas um fator de risco para infecção humana.

  11. Mortalidade perinatal e infantil em Pelotas, Rio Grande do Sul: nossas estatísticas são confiáveis?

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    Fernando C. Barros

    1985-09-01

    Full Text Available Uma coorte de 6.011 crianças vem sendo acompanhada desde o nascimento em Pelotas, RS. A última avaliação foi realizada quando as crianças tinham 20 meses, em média. Este acompanhamento foi feito através de um censo da cidade, quando todas as 68.600 residências foram visitadas, tendo sido localizadas 87,3% das crianças da coorte. Concomitantemente, todos os óbitos foram monitorizados através de visitas domiciliares, revisão periódica de atestados de óbito na Secretaria da Saúde e revisão de prontuários hospitalares. Com o uso dessa metodologia, foi possível detectar 42,1% de sub-registros de mortes perinatais, com 47,8% para óbitos fetais. Com relação à mortalidade infantil, a proporção de sub-registros foi de 24%.A cohort of 6,011 children is being followed up from birth in Pelotas, RS, Brazil. More than 87% of these children were seen when aged 12-27months (mean = 20 months, when all 68,600 urban households were visited. Deaths were monitored through home visits, the review of hospital casenotes and of death certificates at the Secretariat of Health, and these findings were compared with official statistics. Approximately 42% of perinatal deaths failed to be registered, the corresponding figures being 48% for fetal and 24% for infant deaths. On the other hand, less than 5% of all births failed to be registered. The implications of these findings for health policy-makers are discussed.

  12. Auditoria Médica: atendimento de crianças com asma em uma Unidade de Saúde da Família, Pelotas, RS Medical Auditing: care to asthmatic children in a Family Health Unit, Pelotas, RS

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    Ana Maria Siga Stephan

    2009-06-01

    Full Text Available Descrição do processo de atendimento médico às crianças com asma, mediante auditoria realizada concomitantemente a estudo transversal, conduzido em crianças da área de cobertura de uma Unidade de Saúde da Família, para verificar a prevalência de asma e avaliar o conhecimento materno sobre a doença. Utilizaram-se como fonte de dados os prontuários de família das crianças com asma que se consultaram nos últimos 12 meses. Das 258 crianças com asma identificadas no estudo, 69 (26,7% tinham registros de consultas devido à doença. Havia registros de peso em 76,8% dos prontuários, de frequência respiratória em 26,1%, de tiragem intercostal em 21,7%, de cianose em 1,4% e de orientações sobre o uso da medicação em 33,3%. A frequência de registros de orientações sobre os sinais e sintomas de gravidade e o manejo das crises foi de 15,9% e sobre os fatores desencadeantes, modificações ambientais e comportamentais, 14,5%. Foram encontrados registros de prescrição de broncodilatador para 55,1% das crianças, e de corticoesteroide mais broncodilatador para 42,0%. Os baixos percentuais de registros sobre orientações evidenciam as deficiências no atendimento médico realizado na Unidade de Saúde da Família, sobretudo no que se refere à educação em saúde.This is a description of the process of medical care to children with asthma, through an audit carried out concomitantly with a cross-sectional study with children living in the catchment area of a Family Health Unit, to find the prevalence of asthma and to assess maternal knowledge about the disease. Medical records of families whose children had asthma and visited doctors in the previous 12 months were used as sources of data. Of the 258 children identified with asthma, 69 (26.7% had visited the unit because of the disease. Weight was recorded in 76.8% of the medical records, respiratory frequency in 26.1%, intercostal retractions in 21.7%, cyanosis in 1.4%, and orientations on the use of medication in 33.3%. Orientations on the signs and symptoms of severity and crisis management were recorded in 15.9% of the charts and trigger factors, environmental changes, and behavior were recorded in 14.5% of them. There were records of prescription of bronchodilators for 55.1% of the children and of bronchodilator plus corticosteroid for 42.0% of them. The low percentage of records of orientation is an evidence of the deficiencies of medical care in Family Health Units, especially regarding education in health.

  13. Macroinvertebrados bentônicos como indicadores de qualidade de água na Barragem Santa Bárbara, Pelotas, RS, Brasil Zoobenthics as indicators of the water quality in the Santa Bárbara Dam, Pelotas, RS, Brazil

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    Sérgio Renato Noguez Piedras

    2006-04-01

    Full Text Available O objetivo deste trabalho foi estudar o impacto de dois afluentes da barragem Santa Bárbara sobre o ambiente da mesma, utilizando a ocorrência de invertebrados bentônicos e características químicas da água. Durante nove meses foram realizadas coletas e análises da água e de invertebrados bentônicos nos afluentes Sanga da Barbuda e Sanga do Passo do Cunha e também no interior da bacia de acumulação da barragem. Os resultados mostram que, embora a Sanga da Barbuda e a Sanga do Passo do Cunha apresentem características químicas abaixo do recomendável, no limite aceitável pela legislação que determina os padrões de qualidade da água para abastecimento público, estes afluentes estão, ainda, sendo diluídos de forma satisfatória na bacia de acumulação da barragem. O estudo das relações entre variáveis químicas e invertebrados bentônicos mostra haver correlação significativa entre os baixos níveis de oxigênio dissolvido e a presença de Oligochaeta, sendo que o aumento do número de Oligochaeta indica uma situação de anoxia na barragem Santa Bárbara.The objective of this work was to study the impact of two tributaries from the Santa Bárbara Dam on this environment using the occurrence of zoobenthics and some water chemical characteristics. Monthly gathering and analysis from the water and zoobenthics were done during nine months in the tributaries Sanga da Barbuda and Sanga Passo do Cunha as well as in the inner part of the accumulation basin in the Santa Barbara dam. The results demonstrate that, though Sanga da Barbuda and Sanga Passo do Cunha present chemical characteristics lower than the recommended but still in the limits acceptable by the law that regulates the water quality standards for the supply, these tributaries are being diluted in a satisfactory way in the accumulation basin in the Santa Barbara dam. The study of the relations between chemical variables and zoobenthics show a significant correlation between low levels of dissolved oxygen and the presence of Oligochaeta; moreover, the increase of Oligochaeta indicates a situation of anoxia in the Santa Barbara Dam.

  14. Feeding of Hoplias aff. malabaricus (Bloch, 1794 and Oligosarcus robustus Menezes, 1969 in a lagoon under estuarine influence, Pelotas, RS

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    Fabiano Corrêa

    2009-09-01

    Full Text Available The objective of the present paper was to study the diets of Hoplias aff. malabaricus and Oligosarcus robust in “Pequena Lagoon” and evaluate the importance of estuarine organisms in the feeding of freshwater fish. A total of twelve food categories were identified and it was established that the fish resource was the most frequent in the diet of both species. Euryhaline fish such as Mugil platanus mullets and Odontesthes argentinensis silversides were common items in the diets of these two species, which included not only freshwater fish but also euryhaline fish from the adjacent estuarine zone, integrating both resources in the food chain.

  15. RS-predictor

    DEFF Research Database (Denmark)

    Zaretzki, Jed; Bergeron, Charles; Rydberg, Patrik;

    2011-01-01

    This article describes RegioSelectivity-Predictor (RS-Predictor), a new in silico method for generating predictive models of P450-mediated metabolism for drug-like compounds. Within this method, potential sites of metabolism (SOMs) are represented as "metabolophores": A concept that describes...... shown to reliably identify at least one observed site of metabolism in the top two rank-positions on 78% of the substrates. Comparisons between RS-Predictor and previously described regioselectivity prediction methods reveal new insights into how in silico metabolite prediction methods should......-validated RS-Predictor models were generated for a set of 394 substrates of CYP 3A4 as a proof-of-principle for the method. Rank aggregation was then employed to merge independently generated predictions for each substrate into a single consensus prediction. The resulting consensus RS-Predictor models were...

  16. Incentivo à leitura nas bibliotecas escolares da rede pública municipal de Pelotas e a inexistência de políticas públicas sistematizadas (1987-2003

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    Renata Braz Gonçalves

    2007-04-01

    Full Text Available A pesquisa buscou investigar a existência de uma política sistematizada de incentivo à leitura na rede pública municipal de ensino de Pelotas/RS, entre os anos de 1987 e 2003. A metodologia utilizada abarcou a revisão bibliográfica e a pesquisa documental, tendo como fontes documentos pertencentes aos arquivos inativos da Secretaria Municipal de Educação de Pelotas. Constatou-se que, nesse período, não houve uma política sistematizada de incentivo à leitura por parte do governo municipal e que mínimos foram os reflexos dos programas nacionais de incentivo à leitura na rede de ensino estudada. No entanto, verificou-se a preocupação e a insistência de muitos professores, principalmente aqueles que atuavam em bibliotecas das escolas municipais, em promover o incentivo à leitura. Dessa forma, este artigo mostra que dificuldades foram enfrentadas e que estratégias foram utilizadas por esses professores para amenizar tais limitações.

  17. Óbitos evitáveis até 48 meses de idade entre as crianças da Coorte de Nascimentos de Pelotas de 2004 Óbitos evitables hasta los 48 meses de edad entre los niños de La Cohorte de Nacimientos de Pelotas de 2004 Avoidable deaths until months of age among children from the 2004 Pelotas birth cohort

    Directory of Open Access Journals (Sweden)

    Luis Ramon Marques da Rocha Gorgot

    2011-04-01

    Full Text Available OBJETIVO: Descrever óbitos evitáveis de crianças pertencentes à Coorte de Pelotas, RS, de 2004. MÉTODOS: O óbito de 92 crianças entre 2004-2008 da Coorte de Pelotas 2004 foi identificado e classificado conforme a Lista de Causas de Mortes Evitáveis por Intervenções do Sistema Único de Saúde. Os Sistemas de Informação sobre Mortalidade (SIM municipal e estadual foram rastreados para localizar mortes ocorridas fora de Pelotas e as causas após o primeiro ano vida. O óbito de menores de um ano foi avaliado e comparado entre um subestudo e o SIM. Foram calculados coeficientes de mortalidade: 1.000 nascidos vivos (NV, mortalidade proporcional por causas evitáveis e conforme tipo de unidade básica de saúde (tradicional ou Estratégia Saúde da Família. RESULTADOS: O coeficiente de mortalidade foi de 22,2:1.000 NV, 82 óbitos ocorreram no primeiro ano de vida (19,4:1.000 NV, dos quais 37 (45% na primeira semana. Mais de ¾ dos óbitos (70/92 eram evitáveis. No primeiro ano de vida, a maioria (42/82 das mortes seriam evitadas pela adequada atenção à mulher durante a gestação; de acordo com o SIM, a maioria (n = 32/82, pela adequada atenção ao recém-nascido. Não houve diferença entre o tipo de Unidade Básica de Saúde quanto à proporção de óbitos evitáveis. CONCLUSÕES: É alta a proporção de óbitos infantis que podem ser evitados. Para que os óbitos evitáveis possam ser utilizados como indicadores no monitoramento da qualidade da atenção à saúde materno-infantil, é necessário aprimorar a qualidade dos os registros das Declarações de Óbito.OBJETIVO: Describir óbitos evitables de niños pertenecientes a la Cohorte de Pelotas, Sur de Brasil, de 2004. MÉTODOS: Los óbitos de 92 niños entre 2004-2008 de la Cohorte de Pelotas 2004 fueron identificados y clasificados conforme la Lista de Causas de Muertes Evitables por Intervenciones del Sistema Único de Salud de Brasil. Los sistemas de información sobre

  18. Taming troubled teens: The social production of mental morbidity amongst young mothers in Pelotas, Brazil

    OpenAIRE

    Béhague, D.P.; Goncalves, H. D.; Gigante, D; Kirkwood, B. R.

    2012-01-01

    Copyright @ 2011 Elsevier Ltd. This is a post-print version of the article. The published version of the article can be viewed at the link below. Explanations for the association between teen-childbearing and subsequent mental morbidity vary considerably, from those based on neurological theories of development to those investigating underlying social and economic determinants. Based on longitudinal epidemiological and ethnographic sub-studies of the 1982 Pelotas birth cohort study, this p...

  19. Estudo de prevalência das fraturas bucomaxilofaciais na região de Pelotas = Study of prevalence of the bucomaxilofacial fractures in Pelotas region

    Directory of Open Access Journals (Sweden)

    Portolan, Moacir

    2005-01-01

    Full Text Available Analisamos 745 casos de fraturas bucomaxilofaciais registrados no SAME (Serviço de Arquivo Médico Estatístico da Santa Casa de Misericórdia de Pelotas e no Centro de Estudos e Reabilitação Bucomaxilofacial de Pelotas (CERBMF, no período de 10 de janeiro de 1996 a 31 de dezembro de 2000. Os dados formam colhidos e anotados em fichas, as quais totalizaram 745 casos de pacientes submetidos à cirurgia. O nariz foi o local mais atingido, seguido pelo osso zigomático e mandíbula. As agressões foram as principais causas de fraturas, seguidas por acidentes de trânsito e quedas. O gênero masculino foi o mais atingido, numa proporção de 8/2 em relação ao feminino. A faixa etária mais atingida foi a de 21 a 30 anos de idade, seguida pela de 31 a 40 anos de idade e 11 a 20 anos de idade

  20. Biochronostratigraphy of the Pelotas Basin: Actual state and application in the petroleum geology; Biocronoestratigrafia da Bacia de Pelotas: estado atual e aplicacao na geologia do petroleo

    Energy Technology Data Exchange (ETDEWEB)

    Anjos-Zerfass, Geise de Santana dos; Souza, Paulo Alves de; Chemale Junior, Farid [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Inst. de Geociencias]. E-mails: geise.anjos@ufrgs.br; paulo.alves.souza@ufrgs.br, farid.chemale@ufrgs.br

    2008-07-01

    The bio stratigraphic studies of the Brazilian sedimentary basins have providing a support for the exploratory research of energetic and mineral resources, in particular at the continental margin. From new discoveries of hydrocarbon accumulations at the Santos and Campos basins, the south portion of the Brazilian continental margin were converted in an important target of the exploration. Therefore, the bio stratigraphic refinement is necessary to detect gaps and to promote an increment on the precision of the lateral correlations in the delimitation and spatial analysis of the potential reservoirs. The actual stage of the bio-chronostratigraphic framework of the Pelotas Basin is presented herein, focusing on its application to the reservoir prospection. The main questions and lacunae on the knowledge are also discussed. In terms of bio stratigraphy, the Pelotas Basin remains poorly evaluated, despite publication of important works on the bio stratigraphy are known since the 1960's. A comparison of bio stratigraphic schemes proposed for the Tertiary section of the basin allows the inference of diverse hiatuses, identified by the absences of bio zones. Hiatuses identified in the {sup 87}Sr/{sup 86}Sr curve, suggest their relationship with discontinuities in the deposition. Discrepancies between the proposed schemes can be attributed to the particular resolution of the different groups used, the variations in the bio stratigraphic criteria and the sampling interval, influencing the bio stratigraphic resolution and therefore its potential as a correlation tool. (author)

  1. RS-WebPredictor

    DEFF Research Database (Denmark)

    Zaretzki, J.; Bergeron, C.; Huang, T.-W.;

    2013-01-01

    . RS-WebPredictor is the first freely accessible server that predicts the regioselectivity of the last six isozymes. Server execution time is fast, taking on average 2s to encode a submitted molecule and 1s to apply a given model, allowing for high-throughput use in lead optimization projects...

  2. [MaRS Project

    Science.gov (United States)

    Aruljothi, Arunvenkatesh

    2016-01-01

    The Space Exploration Division of the Safety and Mission Assurances Directorate is responsible for reducing the risk to Human Space Flight Programs by providing system safety, reliability, and risk analysis. The Risk & Reliability Analysis branch plays a part in this by utilizing Probabilistic Risk Assessment (PRA) and Reliability and Maintainability (R&M) tools to identify possible types of failure and effective solutions. A continuous effort of this branch is MaRS, or Mass and Reliability System, a tool that was the focus of this internship. Future long duration space missions will have to find a balance between the mass and reliability of their spare parts. They will be unable take spares of everything and will have to determine what is most likely to require maintenance and spares. Currently there is no database that combines mass and reliability data of low level space-grade components. MaRS aims to be the first database to do this. The data in MaRS will be based on the hardware flown on the International Space Stations (ISS). The components on the ISS have a long history and are well documented, making them the perfect source. Currently, MaRS is a functioning excel workbook database; the backend is complete and only requires optimization. MaRS has been populated with all the assemblies and their components that are used on the ISS; the failures of these components are updated regularly. This project was a continuation on the efforts of previous intern groups. Once complete, R&M engineers working on future space flight missions will be able to quickly access failure and mass data on assemblies and components, allowing them to make important decisions and tradeoffs.

  3. Trails, RS2477, RS2477, Published in 2005, Daggett County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2005. It is described as 'RS2477'. Data by this publisher are often provided...

  4. RS-232 Led Board

    CERN Document Server

    Tskhvaradze, Vladimir

    2007-01-01

    This article demonstrates how to develop a Microchip PIC16F84 based device that supports RS-232 interface with PC. Circuit (LED Board) design and software development will be discussed. PicBasic Pro Compiler from microEngineering Labs, Inc. is used for PIC programming. Development of LED Board Control Console using C/C++ is also briefly discussed. The project requires basic work experience with Microchip PICs, serial communication and programming.

  5. Monitoramento da ação genotóxica em trabalhadores de sapatarias através do teste de micronúcleos, Pelotas, Rio Grande do Sul Monitoring the genotoxic action in shoe workers by micronucleus test, Pelotas, Rio Grande do Sul State

    Directory of Open Access Journals (Sweden)

    Natália Silveira Corrêa

    2009-12-01

    Full Text Available Neste trabalho, investigou-se a frequência de micronúcleos em células esfoliadas da mucosa bucal de trabalhadores de sapatarias, na cidade de Pelotas (RS. O estudo constou de 54 trabalhadores de sapatarias expostos à cola e solventes e 54 controles. Avaliou-se a incidência de células com micronúcleos(CMN, binucleadas(CBN, núcleos ligados(CNL e total de anomalias(TA, em 2.000 células por indivíduo. Elaborou-se um banco de dados no programa SPSS "for Windows" pelo teste de Mann-Whitney U, pIn this paper it was investigated the micronuclei frequency in exfoliated oral mucosa cells in shoe shop workers in the city of Pelotas, RS. The study counted on 54 shoe workers exposed to glue and solvents and 54 controls. It was evaluated the incidence of cells with micronucleus (CMN, bi-nucleus (CBN, linked nucleus (CLN and total amount of anomalies (TAA, in 2000 cells per person. A database was created in the SPSS "for Windows" software using the Mann-Whitney U, p<0.05 test. The average of anomalies among shoe workers was 8.69±6.49CMN; 8.85±4.92CBN; 5.78±4.78CNL; 23.31±10.01TA, in the controlled 4.00±5.05CMN; 4.63±4.35CBN; 4.76±5.00CNL; 13.39±9.43TA (p=0.0001; p=0.0001; p=0.144 and p=0.0001 respectively. It was also evaluated the age, gender, time of work, family income, smoke, alcohol beverages, the influence of dermatological, ophthalmological, respiratory and central nervous system (CNS diseases in the number of cell anomalies. These items did not have any influence. It was only observed that among the age group of 15 to 29 years old the number of CNL was bigger than among the age group of 45 to 72. Among those with time of work of 0.1 and 10 years presented a higher CNM than in the other group range.

  6. Self-Medication Among Adolescents Aged 18 Years: The 1993 Pelotas (Brazil) Birth Cohort Study

    OpenAIRE

    Bertoldi, Andréa Dâmaso; Camargo, Aline Lins; Silveira, Marysabel Pinto Telis; Ana M. B. Menezes; Assunção, Maria Cecília Formoso; Gonçalves, Helen; Hallal, Pedro Curi

    2014-01-01

    Purpose To estimate the point prevalence of self-medication among adolescents aged 18 years and to evaluate the type of drugs used (either over-the-counter or prescription drugs) and socioeconomic, health-related, and behavioral correlates of self-medication. Methods This cross-sectional study used data from the 1993 Pelotas (Brazil) Birth Cohort Study. Data were obtained through the administration of a questionnaire to adolescents aged 18 years. The outcome variables were point prevalence of...

  7. Lifetime overweight and obesity and body composition in adulthood: the 1982 Pelotas (Brazil) birth cohort study.

    Science.gov (United States)

    Callo, Gabriela; Gigante, Denise Pretucci; Barros, Fernando C; Horta, Bernardo Lessa

    2016-01-01

    This study aimed to assess the association between overweight/obesity at different moments in the life cycle and body composition in early adulthood. Data were used from the 1982 Pelotas (Brazil) birth cohort study, which has followed live born children of families residing in the urban area of Pelotas at different ages. At 30 years of age, 3,701 cohort members were interviewed and body composition was assessed using Bod Pod, 2,219 cohort members had at least one weight and height measurement taken in the three periods (childhood, adolescence, and adulthood), 24% never presented overweight, and 68.6% were never classified as obese. Elevated body mass index (BMI) and percent body fat at 30 years of age were associated with individuals classified as overweight in all three periods or in adolescence and adulthood, while those with overweight/obesity only in childhood or adolescence showed mean BMI and percent body fat similar to those who had never presented overweight/obesity. The results indicate the benefit of early interruption of overweight/obesity.

  8. The Pelotas birth cohort study, Rio Grande do Sul, Brazil, 1982-2001

    Directory of Open Access Journals (Sweden)

    Victora Cesar G.

    2003-01-01

    Full Text Available Given the growing recognition of the importance of the life course approach for the determination of chronic diseases, birth cohort studies are becoming increasingly important. This paper describes the methods used in the 1982 Pelotas (Brazil birth cohort study, one of the largest and longest studies of this type in developing countries. All 5,914 hospital births occurring in Pelotas in 1982 (over 99% of all deliveries were studied prospectively. The main stages of the study took place in 1983, 1984, 1986, 1995, 1997, 2000, and 2001. More than two thousand variables are available for each subject who participated in all stages of the study. Recent phases of the study included the examination of 2,250 males when presenting for the army recruitment exam in 2000, the study of a 27% sample of men and women in 2001 through household visits, and the study of over 400 children born to the cohort women. Follow-up rates in the recent stages of the cohort were 78.9% for the army examination and 69.0% for the household visits. Ethnographic and oral health studies were conducted in sub-samples. Some recent results on blood pressure, adolescent pregnancy, and asthma are presented as examples of utilization of the data. Suggestions on lessons learned for other cohort studies are proposed.

  9. THE ISSUE OF PELOTAS' SLUMS BETWEEN THE 19TH AND 20TH CENTURIES

    Directory of Open Access Journals (Sweden)

    Letícia Nörnberg Maciel

    2014-10-01

    Full Text Available The following paper talks about the formation, urban expansion and the emergence of 19th and early 20th century slums at Pelotas city, Rio Grande do Sul state. Since the rise of this kind of residential building, during the second half of the 19th century up to, at least, the 1920s – the last decade covered by this research – government and local elites had been putting a great effort in order to move away these residences towards the outskirts of the city. All of this ideas were paved around hygienist ideals. Lots and edifications in downtown Pelotas had an increase in economic value because of the expansion of that area. That being said, it was important to force a migration of these slums, away from central areas, based upon aesthetic reasons and in order to increase even more the value of the area.

  10. The Pelotas Birth Cohort Study, Rio Grande do Sul, Brazil, 1982-2001

    Science.gov (United States)

    2010-01-01

    Given the growing recognition of the importance of the life course approach for the determination of chronic diseases, birth cohort studies are becoming increasingly important. This paper describes the methods used in the 1982 Pelotas (Brazil) birth cohort study, one of the largest and longest studies of this type in developing countries. All 5,914 hospital births occurring in Pelotas in 1982 (over 99% of all deliveries) were studied prospectively. The main stages of the study took place in 1983, 1984, 1986, 1995, 1997, 2000, and 2001. More than two thousand variables are available for each subject who participated in all stages of the study. Recent phases of the study included the examination of 2,250 males when presenting for the army recruitment exam in 2000, the study of a 27% sample of men and women in 2001 through household visits, and the study of over 400 children born to the cohort women. Follow-up rates in the recent stages of the cohort were 78.9% for the army examination and 69.0% for the household visits. Ethnographic and oral health studies were conducted in sub-samples. Some recent results on blood pressure, adolescent pregnancy, and asthma are presented as examples of utilization of the data. Suggestions on lessons learned for other cohort studies are proposed. PMID:14666206

  11. Uso estratégico del espacio en categorías de formación de pelota vasca. [Strategic use of space in basque pelota training categories].

    Directory of Open Access Journals (Sweden)

    Oidui Usabiaga

    2014-04-01

    Full Text Available La pelota vasca es un deporte de pelota compuesto por varias especialidades. La pelota a mano es una de las más practicadas y se juega tanto en duelos individuales como por equipos. El presente estudio pretende analizar y comparar algunos indicadores de juego del uso estratégico del espacio por parte de jugadores benjamines (8-10 años y alevines (10-12 años que participan en un programa de deporte escolar. La muestra estuvo compuesta por doce partidos, seis de benjamines (30 participantes y seis de alevines (30 participantes. El registro se llevó a cabo mediante un instrumento observacional ad hoc diseñado para analizar el uso estratégico del espacio por parte de los participantes, tanto cuando golpean la pelota como cuando están en situación de espera. Los resultados muestran que los participantes de las dos categorías usan el espacio de la misma forma respecto a las zonas de golpe, la ubicación espacial en situación de espera durante los duelos por parejas y los tipos de saque. Los alevines, en comparación a los benjamines, se posicionan más a la derecha del jugador que golpea durante los duelos individuales, dirigen la pelota a distancias medias y cometen menos faltas tanto en el resto del saque como en el juego de intercambio, dando mayor continuidad al juego (p Abstract The basque pelota is a ball sport composed of various specialties. The hand pelota is one of the most popular and is played in both individual and team matchups. The aim of this study was to analyze and compare some indicators of the strategic use of space by young players, 8-10- and 10-12-year-old students, participating in a school sport program. The sample consisted of twelve games, six for each level (30 participants for each level. Data were recorded with an ad hoc observational instrument designed to analyze the strategic use of space by the participants, both when they hit the ball and when they are on standby. The results show that the participants of

  12. The Pelotas birth cohort study, Rio Grande do Sul, Brazil, 1982-2001 Estudo de coorte de nascimentos em Pelotas, Rio Grande do Sul, Brasil, 1982-2001

    Directory of Open Access Journals (Sweden)

    Cesar G. Victora

    2003-10-01

    Full Text Available Given the growing recognition of the importance of the life course approach for the determination of chronic diseases, birth cohort studies are becoming increasingly important. This paper describes the methods used in the 1982 Pelotas (Brazil birth cohort study, one of the largest and longest studies of this type in developing countries. All 5,914 hospital births occurring in Pelotas in 1982 (over 99% of all deliveries were studied prospectively. The main stages of the study took place in 1983, 1984, 1986, 1995, 1997, 2000, and 2001. More than two thousand variables are available for each subject who participated in all stages of the study. Recent phases of the study included the examination of 2,250 males when presenting for the army recruitment exam in 2000, the study of a 27% sample of men and women in 2001 through household visits, and the study of over 400 children born to the cohort women. Follow-up rates in the recent stages of the cohort were 78.9% for the army examination and 69.0% for the household visits. Ethnographic and oral health studies were conducted in sub-samples. Some recent results on blood pressure, adolescent pregnancy, and asthma are presented as examples of utilization of the data. Suggestions on lessons learned for other cohort studies are proposed.Em função do reconhecimento crescente do enfoque do ciclo vital na determinação de doenças crônicas, estudos de coorte de nascimentos são cada vez mais importantes. Este artigo descreve a metodologia do estudo de coorte de nascidos em Pelotas, em 1982, um dos maiores e mais longos estudos de coorte em países em desenvolvimento. Todos os 5.914 nascimentos hospitalares (mais de 99% de todos os nascimentos ocorridos em 1982 foram estudados prospectivamente. As principais fases do estudo foram realizadas em 1983, 1984, 1986, 1995, 1997, 2000 e 2001. Mais de duas mil variáveis estão disponíveis para sujeitos incluídos em todas as fases do estudo. As fases recentes

  13. Fatores de risco para a asma em adultos, Pelotas, Rio Grande do Sul, Brasil Risk factors for asthma in adults in Pelotas, Rio Grande do Sul State, Brazil

    Directory of Open Access Journals (Sweden)

    Silvia Elaine Cardozo Macedo

    2007-04-01

    Full Text Available A incidência e mortalidade por asma vêm aumentando em vários países do mundo. Com o objetivo de avaliar a prevalência e fatores de risco para a asma na população adulta de Pelotas, Rio Grande do Sul, Brasil, conduziu-se um estudo populacional e transversal, em amostra de 1.968 pessoas, dos 20 a 69 anos de idade. A prevalência de "sintomas atuais de asma" foi de 6%, observando-se variação com diferentes critérios diagnósticos. Na análise bruta, os fatores de risco observados foram: sexo feminino, faixa etária dos 60 aos 69 anos, cor da pele não-branca, baixas escolaridade e renda familiar, história familiar de asma e atopia, atopia pessoal, tabagismo, índice de massa corporal baixo e distúrbios psiquiátricos menores. Na análise multivariada permaneceram os seguintes fatores de risco: história paterna e materna de asma, distúrbios psiquiátricos menores, idade de 60 a 69 anos, renda familiar inferior a 1,01 salário mínimo, atopia pessoal e sexo feminino. Os resultados salientam a variação na prevalência de asma com diferentes critérios diagnósticos, e que fatores genéticos, sociais e relacionados ao estilo de vida são relevantes na ocorrência da doença.Asthma incidence and mortality rates have increased in recent years. The present cross-sectional survey aimed to measure asthma prevalence and risk factors in a random sample of 1,968 individuals (20-69 years of age in Pelotas, Rio Grande do Sul State, Brazil. Overall prevalence of "current asthma symptoms" was 6%, varying according to diagnostic criteria. Associated risk factors in the crude analyses were: female gender, age 60-69 years, non-white skin color, low education, low family income, family history of atopy and asthma, personal history of atopic disease, smoking, low body mass index, and minor psychiatric disorders. In the multivariate analysis the following risk factors remained associated with "current asthma symptoms": mother and father with asthma

  14. Thermal behavior of resistant starches RS 2, RS 3, and RS 4.

    Science.gov (United States)

    Ratnayake, W S; Jackson, D S

    2008-06-01

    The thermal behaviors of 3 resistant starch types-RS 2, RS 3, and RS 4-were investigated. Samples were heated in excess water to specific temperatures, from 35 to 85 degrees C at 5 degrees C intervals, and freeze-dried. The treated samples were analyzed using SEM, DSC, XRD, and HPSEC to determine the structural changes at granular and molecular levels. Light microscopy was used to determine real-time thermal behavior of the starches. Although the resistant starches did not show significant morphological changes, as revealed by microscopy, they underwent internal structural changes at low temperatures before complete phase transitions occurred. The structural changes were less in RS 2 compared to the other 2 starches studied. The nongranular material of RS 3's crystallinity decreased gradually from 35 to 85 degrees C and showed microscopically visible changes at >80 degrees C. Cross-linking might have prevented RS 4 from becoming completely amorphous within the temperature range (35 to 85 degrees C) tested. The study indicated that the extent of structural changes depended on the treatment temperature and RS type.

  15. Leisure-time physical activity during pregnancy in the 2004 Pelotas Birth Cohort Study Atividade física de lazer entre as gestantes da coorte de nascimentos de Pelotas de 2004

    Directory of Open Access Journals (Sweden)

    Marlos Rodrigues Domingues

    2007-04-01

    Full Text Available OBJECTIVE: Physical activity during pregnancy is a poorly investigated subject on population level. The study aimed to describe duration, type and frequency of leisure-time physical activity during pregnancy, and to explore its associated factors. METHODS: A population-based study was carried out during 2004 in Southern Brazil. A total of 4,471 mothers were interviewed soon after delivery. Physical activity was measured using a questionnaire, developed for the study. Results were obtained by Poisson regression. RESULTS: In the sample, 14.8% of women reported to engage in some type of physical activity prior to pregnancy and 12.9% during pregnancy. In the first trimester, 10.4% of all mothers engaged in some type of physical activity; 8.5% in the second trimester and 6.5% in the third trimester. Only 194 mothers (4.3% were active during the whole pregnancy. In the adjusted analysis, leisure-time physical activity was positively associated with schooling, physical activity advice during prenatal care, and family income (pOBJETIVO: A atividade física durante a gestação é pouco estudada em nível populacional. O objetivo do estudo foi descrever a duração, tipo e freqüência de atividade física de lazer durante a gravidez e explorar fatores associados. MÉTODOS: Estudo de base populacional, realizado durante o ano de 2004 em Pelotas, RS, Brasil. Logo após o parto, 4.471 mães foram entrevistadas. Utilizou-se questionário, desenvolvido para o estudo, para verificar a atividade física de lazer. Os resultados foram obtidos por regressão de Poisson. RESULTADOS: Antes da gravidez, 14,8% das mulheres relataram algum tipo de atividade física de lazer e durante, 12,9%. No primeiro trimestre, 10,4% de todas as mães fizeram alguma atividade física de lazer; no segundo, 8,5% e no terceiro, 6,5%. Apenas 194 mães (4,3% foram ativas durante toda a gestação. Na análise ajustada, atividade física de lazer esteve positivamente associada com

  16. Predictors and Health Consequences of Screen-Time Change During Adolescence—1993 Pelotas (Brazil) Birth Cohort Study

    OpenAIRE

    Dumith, Samuel Carvalho; Leandro Martin Totaro GARCIA; da Silva, Kelly Samara; Menezes, Ana Maria Baptista; Hallal, Pedro Curi

    2012-01-01

    Purpose To investigate screen-time change from early to mid adolescence, its predictors, and its influence on body fat, blood pressure, and leisure-time physical activity. Methods We used data from a longitudinal prospective study, conducted among participants of the 1993 Pelotas (Brazil) Birth Cohort Study. At baseline, adolescents were, on average, 11 years old. They were later visited at age 15 years. Screen time was self-reported, accounting for the time spent watching television, playing...

  17. Methods and logistics of a multidisciplinary survey of schoolchildren from Pelotas, in the Southern Region of Brazil Métodos y logística de un estudio multidisciplinar con escolares de Pelotas, sur de Brasil Métodos e logística de um estudo multidisciplinar com escolares de Pelotas, Sul do Brasil

    OpenAIRE

    Marlos Rodrigues Domingues; Margarete Marques; Dione Dias Torriani; Fabiana Vargas-Ferreira; Marcos Britto Correa; Marília Leão Goettems; Pedro Curi Hallal; Flávio Fernando Demarco

    2013-01-01

    This paper describes the methods of a multidisciplinary epidemiological survey conducted in schools in Pelotas, in the Southern Region of Brazil. This cross-sectional study evaluated a representative sample (n = 1,211) of eight to 12-year-old children attending public (15) and private (5) schools. Questionnaires were applied to parents to obtain information about socioeconomic and sociocultural characteristics. Children were interviewed to provide information on demographic characteristics, o...

  18. Interleukin-6-receptor polymorphisms rs12083537, rs2228145, and rs4329505 as predictors of response to tocilizumab in rheumatoid arthritis

    DEFF Research Database (Denmark)

    Enevold, Christian; Baslund, Bo; Linde, Louise;

    2014-01-01

    Tocilizumab (TCZ), a monoclonal antibody targeting the human interleukin-6-receptor (IL-6R), is indicated for the treatment of rheumatoid arthritis (RA). We examined whether three IL6R single-nucleotide polymorphisms rs12083537, rs2228145 (formerly rs8192284), and rs4329505 with previously reported...... for association with the IL6R-haplotype or genotype. The major allele (A) of rs12083537 and the minor allele (C) of rs4329505 were associated with a poor SJC response (P=0.02 and 0.02, respectively). Moreover, the AAC-haplotype (for rs12083537, rs2228145, and rs4329505, respectively) was associated with a poor...... SJC response (P=0.00004) and, with borderline significance, EULAR-response (P=0.05). These data suggest that genetic variation in IL6R may aid in predicting TCZ therapy outcome in RA patients....

  19. Criminal victimization in childhood and adolescence according to official records: the Pelotas (Brazil) birth cohort study.

    Science.gov (United States)

    Gallo, Erika Alejandra Giraldo; Menezes, Ana Maria B; Murray, Joseph; Silva, Luciana Anselmi Duarte da; Wehrmeister, Fernando César; Gonçalves, Helen; Barros, Fernando

    2016-01-01

    This article describes different types of officially recorded victimization among 5,249 children in the 1993 birth cohort in the city of Pelotas, Rio Grande do Sul State, Brazil. Official data were obtained from the Secretariat for Public Security and the Special Court for Children and Youth. Victimization was registered for in 1,150 cohort members, with 1,396 incidents recorded as of December 31, 2012. The total incidence of victimization was 15.7 ocorrences per 1,000 person-years, with the majority involving violent victimization (12.7 per 1,000 person-years). Victimization increased gradually in childhood and rapidly throughout adolescence. The highest incidence rates were among females (p < 0.05), the poor (p < 0.05), children of adolescent mothers (p < 0.001), and children of single mothers (p < 0.05). The most common violent victimization types were physical injuries, robbery, and crimes against personal freedom; non-violent victimization mainly involved theft. Studies like this help identify lifetime risk and protective factors for victimization, highlighting the importance of surveillance and control measures against violence. PMID:27580232

  20. Criminal victimization in childhood and adolescence according to official records: the Pelotas (Brazil) birth cohort study

    Science.gov (United States)

    Giraldo Gallo, Erika Alejandra; Menezes, Ana Maria B.; Murray, Joseph; Duarte da Silva, Luciana Anselmi; Wehrmeister, Fernando César; Gonçalves, Helen; Barros, Fernando

    2016-01-01

    This article describes different types of officially recorded victimization among 5,249 children in the 1993 birth cohort in the city of Pelotas, Rio Grande do Sul State, Brazil. Official data were obtained from the Secretariat for Public Security and the Special Court for Children and Youth. Victimization was registered for in 1,150 cohort members, with 1,396 incidents recorded as of December 31, 2012. The total incidence of victimization was 15.7 ocorrences per 1,000 person-years, with the majority involving violent victimization (12.7 per 1,000 person-years). Victimization increased gradually in childhood and rapidly throughout adolescence. The highest incidence rates were among females (p < 0.05), the poor (p < 0.05), children of adolescent mothers (p < 0.001), and children of single mothers (p < 0.05). The most common violent victimization types were physical injuries, robbery, and crimes against personal freedom; non-violent victimization mainly involved theft. Studies like this help identify lifetime risk and protective factors for victimization, highlighting the importance of surveillance and control measures against violence. PMID:27580232

  1. Autoavaliação de saúde e doenças crônicas entre enfermeiros de Pelotas/RS

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    Adrize Rutz Porto

    2013-09-01

    Full Text Available Descrever a autoavaliação de saúde e a prevalência de doenças crônicas entre enfermeiros. Estudo transversal, realizado com 240 enfermeiros que responderam a questionário estruturado. Fez-se o tratamento dos dados por meio de estatística descritiva e associações com o teste qui-quadrado. A amostra foi composta por enfermeiros, em sua maioria mulheres (90,8% adultas jovens (69,6%, não casadas (55,4% e com filhos (53,4%. Na amostra, 35,4% relataram trabalhar mais de 40h, 40% trabalhavam no período noturno, 31,2% conviviam com doenças crônicas e 37,1% avaliaram sua saúde de razoável a ruim. Obteve-se associação significativa entre doenças crônicas, idade superior a 39 anos (p<0,001 e autoavaliação de razoável a ruim sobre a saúde (p<0,001. Diante dos achados, emerge a necessidade de investimentos na assistência à saúde dos enfermeiros, principalmente no que tange ao convívio com doenças crônicas, o que, por conseguinte, influenciará na autoavaliação da saúde desses profissionais e no cuidado prestado.

  2. The Design Points of RS232 -RS422/RS485/TLL Signal Converter%RS232-RS422/RS485/TLL信号转换器设计

    Institute of Scientific and Technical Information of China (English)

    苏燕; 周士龙

    2012-01-01

    主要介绍了RS232-RS422/485信号转换器在窃电电路、自动方向转换电路、RS232信号补偿电路的设计要点,提出了将RS422接口与TLL接口兼容使用的方法。%This article mainly introduces design points of the RS232 -RS422/485 signal converter's getting power supply from signal pins circuit, automatic direction of transform circuit and RS232 signal compensation circuit. It puts forward the RS422 interface and TLL interface compatibility methods

  3. Elaboración y validación biomecánica de un guante de protección para jugar a pelota valenciana. (Elaboration and biomechanical validation of a protection glove for playing pelota valenciana.

    Directory of Open Access Journals (Sweden)

    Carlos Montaner-Sesmero

    2012-10-01

    Full Text Available ResumenLa pelota valenciana es uno de los antiguos juegos de pelota a mano que perdura en la Comunidad Valenciana. Para amortiguar los impactos de la pelota durante el golpeo, los jugadores se confeccionan sus propias protecciones. En torno a ellas existen diversos factores que dificultan la práctica segura y eficaz de este deporte: el excesivo tiempo empleado en su elaboración, el elevado número de lesiones que sufren en las manos o el inadecuado control de la pelota que consiguen. En base a esto y a la inexistencia de un equipamiento deportivo específico para la mano, se ha desarrollado y validado un guante para intentar solventar estos inconvenientes. En la validación biomecánica se comparó el guante con una protección tipo a nivel de presiones palmares y de precisión y distancia alcanzada en el golpeo. También se registró la opinión de los jugadores acerca del guante con una encuesta. En el ensayo biomecánico participaron 15 jugadores. Para el registro de las presiones palmares se utilizó el equipo Biofoot/IBV® adaptado a la mano. Los resultados muestran que el guante disminuye la presión en tres zonas de la mano, que ofrece la misma precisión y que favorece una mayor distancia de golpeo que las protecciones tradicionales. Los jugadores han valorado satisfactoriamente aspectos como la usabilidad, el ajuste y el confort térmico. En consecuencia, el guante desarrollado disminuye el tiempo de colocación, ofrece mejores prestaciones de protección y es valorado positivamente por los jugadores.Abstract The pelota valenciana game is one of the ancient ball hand game that lasts in the Valencian Community. The players, in order to cushion the hand impacts of the ball during the hits, make their own protections. Around them there are several factors that impede the safe and effective practice of this sport: the excessive time spent in the manufacture, the high number of hand injuries suffered or the inappropriate control of the

  4. Oral health follow-up studies in the 1993 Pelotas (Brazil) birth cohort study: methodology and principal results Estudos de saúde bucal na coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993: metodologia e resultados principais

    OpenAIRE

    Peres, Marco A; Aluísio Jardim Barros; Karen Glazer Peres; Cora Luiza Araújo; Ana M. B. Menezes; Hallal, Pedro C; Victora, Cesar G

    2010-01-01

    The aim of this study was to describe oral health follow-up studies nested in a birth cohort. A population-based birth cohort was launched in 1993 in Pelotas, Rio Grande do Sul State, Brazil. Two oral health follow-up studies were conducted at six (n = 359) and 12 (n = 339) years of age. A high response rate was observed at 12 years of age; 94.4% of the children examined at six years of age were restudied in 2005. The mean DMF-T index at age 12 was 1.2 (SD = 1.6) for the entire sample, rangin...

  5. Trabalho infantil em Pelotas: perfil ocupacional e contribuição à economia

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    Facchini Luiz Augusto

    2003-01-01

    Full Text Available O trabalho infantil é um fenômeno global de grandes proporções, especialmente em países em desenvolvimento. Estima-se que, em todo o mundo, 352 milhões de crianças e adolescentes menores de 18 anos são economicamente ativos, incluindo atividades remuneradas, trabalho não-pago, ilegal e no setor informal da economia. No Brasil, cerca de 9,3 milhões de crianças entre 10 e 17 anos trabalham. Os estudos sobre a contribuição econômica das crianças à renda familiar são escassos. Este artigo apresenta o perfil ocupacional e a contribuição econômica de crianças e adolescentes, com destaque para aspectos relacionados à idade, ao gênero, à escolaridade e à situação socioeconômica de suas famílias em uma amostra de 4.924 indivíduos entre 6 e 17 anos, representativa dos setores urbanos pobres de Pelotas. As crianças e adolescentes trabalhadores contribuíam em média com 18% da renda familiar. Dos que trabalhavam, metade contribuía no mínimo com 10% da renda familiar e um quarto respondia por 25% ou mais da renda familiar. Quanto menor a renda familiar dos adultos, maior a proporção da contribuição de crianças e adolescentes à renda familiar total, maior a exclusão escolar de adolescentes trabalhadores e maior a jornada de trabalho infanto-juvenil.

  6. Factors associated to medicine use among children from the 2004 Pelotas Birth Cohort (Brazil

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    Edilson Almeida de Oliveira

    2012-06-01

    Full Text Available OBJECTIVE: To identify factors associated to medicine use among children from the 2004 Pelotas Birth Cohort, Brazil. METHODS: Prospective study to evaluate medicine use in children aged 3, 12 and 24 months regardless of the reasons, therapeutic indication or class. The study included 3,985 children followed up at three months of age, 3,907 at 12 months, and 3,868 at the last follow-up time of 24 months. Mothers were interviewed to collect information on medicine use during the recall period of 15 days prior to the interview. The outcome was studied according to sociodemographic and perinatal variables, mother's perception of child's health and breastfeeding status. Crude and adjusted analyses were performed by Poisson regression following a hierarchical model. RESULTS: The prevalence of medicine use ranged from 55% to 65% in the three follow-ups. After controlling for confounders, some variables remained associated to medicine use only at the three-month follow-up with greatest use among children of younger mothers, those children who had intrapartum complications, low birthweight, were never breastfed and were admitted to a hospital. Greatest medicine use was also associated with being a firstborn child at 3 and 12 months; mother's perception of their child health as fair or poor and children whose mothers have private health insurance at 12 and 24 months; highest maternal education level at all follow-up times. CONCLUSIONS: Different variables influence medicine use among children during the first two years of life and they change as the child ages especially maternal factors and those associated to the child's health problems.

  7. Cobertura do exame citopatológico na cidade de Pelotas, Rio Grande do Sul, Brasil

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    Juvenal Soares Dias-da-Costa

    2003-02-01

    Full Text Available No Brasil, a avaliação da efetividade de programas de prevenção e ações de saúde pública ainda são incipientes. Dessa forma, realizou-se um estudo transversal de base populacional envolvendo a saúde da população adulta residente na zona urbana da cidade de Pelotas, Rio Grande do Sul, Brasil, com o objetivo de verificar a evolução nos níveis de cobertura do exame citopatológico. Investigaram-se fatores associados com a não realização do procedimento. Considerou-se exame citopatológico atualizado aquele realizado nos últimos três anos. A amostra foi constituída por 1.122 mulheres entre 20 e 69 anos, sendo que 72,2% apresentavam exame citopatológico atualizado, 16,6% atrasado e 11,2% nunca o haviam realizado. A não realização do procedimento esteve associada com baixa inserção social e idade avançada. A regressão logística destacou o efeito independente de classe social, baixa renda familiar, idade, cor da pele, estado civil e ausência de consultas médicas no último ano. Contudo, desapareceu o efeito detectado em mulheres com doenças crônicas. Comparando-se os resultados do estudo realizado em 1992 com o atual, observa-se que a cobertura do exame aumentou de 65,0% para 72,2% (1992 para 1999/2000, entretanto, não atingiu os níveis efetivos para evitar câncer de colo uterino.

  8. Formas de condicionar la verdad con el uso del montaje en La pelota vasca

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    María Antonia Paz Rebollo

    2011-01-01

    Full Text Available Esta investigación tiene como objetivo estudiar la construcción de sentido en La pelota vasca. La piel contra la piedra (Julio Medem, 2003, el documental sobre terrorismo que más éxito comercial y más polémica ha generado en el cine español. A través de un análisis del montaje, este artículo busca descubrir las pautas, esquemas o estructuras narrativas utilizadas por el director para construir el texto fílmico y para influir en la opinión de los espectadores. Para ello se ha creado una base de datos que permite un minuicioso análisis cuantitativo y cualitativo de todAs las intervenciones que hay en la película. Esta propuesta metodológica pretende servir al análisis de otros documentales con similares características narrativas. Las conclusiones obtenidas muestran que el director usa la estructura de parte del documental y las entrevistas a diferentes personalidades del País Vasco para configurar un sentido propio de lo que denomina conflicto vasco, que está muy cercano a las tesis nacionalistas. Queda demostrada la crítica a la acción del PP en sus años de gobierno y el deterioro de la imagen del Estado, principalmente a través de un 80% de referencias negativas sobre las fuerzas de seguridad del Estado. También se prueba que las personas entrevistadas son más o menos creíbles dependiendo de cómo quedan situadas dentro del montaje y de si otros personajes refutan o respaldan lo que dicen.

  9. Inequities in maternal postnatal visits among public and private patients: 2004 Pelotas cohort study

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    Marco Paula L

    2009-09-01

    Full Text Available Abstract Background The postnatal period is the ideal time to deliver interventions to improve the health of both the newborn and the mother. However, postnatal care shows low-level coverage in a large number of countries. The objectives of this study were to: 1 investigate inequities in maternal postnatal visits, 2 examine differences in postnatal care coverage between public and private providers and 3 explore the relationship between the absence of maternal postnatal visits and exclusive breastfeeding, use of contraceptive methods and maternal smoking three months after birth. Methods In the calendar year of 2004 a birth cohort study was started in the city of Pelotas, Brazil. Mothers were interviewed soon after delivery and at three months after birth. The absence of postnatal visits was defined as having no consultations between the time of hospital discharge and the third month post-partum. Logistic regression analysis was used to estimate the association between absence of postnatal visits and type of insurance scheme adjusting for potential confounding factors. Results Poorer women, black/mixed, those with lower level of education, single mothers, adolescents, multiparae, smokers, women who delivered vaginally and those who were not assisted by a physician were less likely to attend postnatal care. Postnatal visits were also less frequent among women who relied in the public sector than among private patients (72.4% vs 96% among public and private patients, respectively, x2 p Conclusion Postpartum care is available for every woman free of charge in the Brazilian Publicly-funded health care system. However, low levels of postpartum care were seen in the study (77%. Efforts should be made to increase the percentage of women receiving postpartum care, particularly those in socially disadvantaged groups. This could include locally-adapted health education interventions that address women's beliefs and attitudes towards postpartum care. There

  10. Increase in child behavior problems among urban Brazilian 4-year olds: 1993 and 2004 Pelotas birth cohorts

    OpenAIRE

    Matijasevich, Alicia; Murray, Elizabeth; Stein, Alan; Anselmi, Luciana; Menezes, Ana M; Santos, Iná S; Barros, Aluísio JD; Gigante, Denise P.; Barros, Fernando C; Cesar G Victora

    2014-01-01

    Background There are an increasing number of reports on time trends in child and adolescent psychological problems but none from low- and middle-income countries, and very few covering the preschool period. The aim was to investigate changes in preschool behavioral/emotional problems in two birth cohorts from a middle-income country born 11 years apart. Methods We analyzed data from the 1993 and 2004 Pelotas birth cohort studies from Brazil. A subsample of 4-year olds from the 1993 cohort (63...

  11. Uso del espacio en pelota vasca en edad escolar: aplicación del análisis secuencia

    OpenAIRE

    Usabiaga, Oidui; Castellano, Julen; Anguera Argilaga, María Teresa

    2016-01-01

    El presente estudio aborda la búsqueda de patrones de conducta asociados al uso del espacio llevadas a cabo por jugadores benjamines (8-10 años) y alevines (10-12 años) de pelota a mano que participan en deporte escolar. La muestra estuvo compuesta por doce partidos (60 jugadores), seis de benjamines (30 jugadores) y seis de alevines (30 jugadores). El registro se llevó a cabo mediante un instrumento de observación diseñado ad hoc para analizar el uso estratégico del espacio...

  12. Exposição ocupacional por material biológico no Hospital Santa Casa de Pelotas - 2004 a 2008 La exposición ocupacional a material biológico en el Hospital Santa Casa de Pelotas - 2004 a 2008 Occupational exposure to biological material at the Hospital Santa Casa de Pelotas - 2004 to 2008

    OpenAIRE

    Lílian Moura de Lima; Camila Cardoso de Oliveira; Katiuscia Milano Rosales de Rodrigues

    2011-01-01

    A pesquisa trata de exposições ocupacionais por material biológico a que foram submetidos os profissionais de saúde, no Hospital Santa Casa de Misericórdia de Pelotas, no período de janeiro de 2004 a junho de 2008. Trata-se de um estudo transversal, descritivo, com abordagem quantitativa. Utilizou-se como instrumento de pesquisa um questionário elaborado com base na ficha de notificação de acidente de trabalho da referida instituição. Os dados foram digitados e analisados no programa Epi-info...

  13. BODY COMPOSITION AND SOMATOTYPE OF PROFESSIONAL AND U23 HAND BASQUE PELOTA PLAYERS.

    Science.gov (United States)

    Urdampilleta, Aritz; Mielgo-Ayuso, Juan; Valtueña, Jara; Holway, Francis; Cordova, Alfredo

    2015-11-01

    Introducción: casi no hay ninguna referencia sobre las características antropométricas, la composición corporal y el somatotipo de la mano de los jugadores de pelota vasca (pelotaris) en la literatura científica. Objetivos: el objetivo de esta investigación fue comparar la composición corporal de pelotaris profesionales y sub-23 para crear el perfil antropométrico de este deporte. Métodos: participaron diez pelotaris sub-23 y ocho pelotaris profesionales. Las medidas antropométricas fueron recogidas siguiendo el protocolo de la Sociedad Internacional de Promoción de Protocolo Cineantropometría (ISAK). La masa grasa (FM) se calculó utilizando la ecuación Yushasz modificada por Carter, y la masa muscular (MM) mediante la ecuación de Lee. Los componentes del somatotipo fueron estimados mediante la ecuación Carter y Heath. El nivel de hidratación de los pelotaris se midió con un analizador tetrapolar de impedancia bioeléctrica (BIA). Resultados: los pelotaris profesionales tienen significativamente menor FM (en % (p = 0,001); en kg (p = 0,025) y en los sumatorios de 4, 6 y 8 pliegues cutáneos (p = 0,001); mayor MM (p = 0,015) y un menor componente endomórfico (p < 0,001) que los pelotaris sub-23. Asimismo, los profesionales tienen una mayor cantidad de agua corporal (p = 0,001) y un diámetro mayor biestiloideo de muñeca (p = 0,014). Los pelotaris profesionales son un morfotipo caracterizado por una baja FM (8,9 ± 1,1%) y una intermedia MM (47 ± 1,7%), además de tener una altura de 183,0 ± 7,1 cm y un peso de 85,9 ± 7,6 kg. Conclusión: los principales resultados de este estudio mostraron que las características antropométricas no modificables por el entrenamiento (por ejemplo, altura, envergadura y diámetro de la muñeca) son componentes importantes para convertirse en un pelotari profesional. Por otra parte, las características relacionadas con el entrenamiento y la dieta han mostrado ser mejores en los pelotaris profesionales (menor FM

  14. Use of contraceptive methods by sexually active teenagers in Pelotas, Rio Grande do Sul State, Brazil Uso de métodos anticoncepcionais em adolescentes sexualmente ativos de 15 a 18 anos em Pelotas, Rio Grande do Sul, Brasil

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    Clarissa Lisbôa Arla da Rocha

    2007-12-01

    Full Text Available This study aimed to assess the prevalence of contraceptive use by adolescents. A cross-sectional study was performed from March to September 2002 in a representative sample of adolescents 15 to 18 years of age in the urban area of Pelotas, Rio Grande do Sul State, Brazil. Multiple-stage sampling was used, and in the 448 census tracts located in the urban area, 90 were sampled and households were visited in each tract. Information was collected on sexual initiation and use of contraceptive methods. Chi-square test was used to compare proportions. The sample included 960 adolescents. 88% of subjects reported the use of any contraceptive method. Condoms were the most commonly used method (63.2%. Low adolescent schooling was the only variable associated with increased risk of non-use of contraceptives. Condom use was higher among males, adolescents whose mothers had 9 or more years of schooling, and those reporting several sexual partners in the previous year. Condoms were the most commonly used contraceptive method.O estudo avaliou o uso de métodos contraceptivos em adolescentes. Entre março e setembro de 2002, realizou-se um estudo transversal na zona urbana da cidade de Pelotas, Rio Grande do Sul, Brasil. A amostragem foi em múltiplos estágios, 90 dos 448 setores censitários da zona urbana de Pelotas foram sorteados e em cada setor 86 residências foram visitadas. Considerou-se a informação do adolescente sobre a prática de relações sexuais e do uso de métodos contraceptivos. Nas comparações entre as proporções utilizou-se o teste do qui-quadrado. Foram entrevistados 960 adolescentes, enquanto que para 79 não foi possível realizar a entrevista. Aproximadamente 88% dos adolescentes usavam algum método contraceptivo. O preservativo masculino foi encontrado como o método mais usado naqueles adolescentes que têm relação sexual (63,2%. A escolaridade do adolescente foi a única variável associada com o uso de contraceptivos. O

  15. Collection of Coleoptera from a poultry farm in Pelotas, Rio Grande do Sul, Brazil Flutuação de Coleoptera em granja avícola, em Pelotas, Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Diego Moscarelli Pinto

    2009-04-01

    Full Text Available To evaluate the population fluctuation of Coleoptera from a poultry farm in Pelotas, Rio Grande do Sul, Brazil, two sampling methods were used: a tube-type trap and a sandwich trap. The analyses of polynomial regression were applied independent of the type of sampling method used. The experiment was carried out for twelve months, from April 2002 to March 2003, in a broiler barn aviary at the Conjunto Agrotécnico Visconde da Graça/UFPEL. A total of 43.945 Coleopterans were captured from the following species: Alphitobius diaperinus, Carcinops troglodytes, Euspilotus rubriculus, Gnathocerus cornutus, Mezium americanum and Somotrichus unifasciatus. Among these, Alphitobius diaperinus was present in all months of the year, with larval population peak in February (235 and lowest capture in August (01. The adult population peak was in March (12,020 and the lowest capture in July (27. The remaining captured Coleopterans did not occur in all twelve months, however they also had population peaks in the months of February and March, which also were the months with the highest temperatures.Para avaliação da flutuação populacional de Coleoptera, em granja avícola, em Pelotas, Rio Grande do Sul, Brasil, foram utilizados dois métodos de coleta: armadilha do tipo tubo e do tipo sanduíche, durante doze meses. A análise de regressão polinomial foi aplicada independentemente do tipo de método de coleta utilizado. O experimento foi conduzido durante 12 meses, de abril de 2002 a março de 2003, em um aviário de aves poedeiras do Conjunto Agrotécnico Visconde da Graça da Universidade Federal de Pelotas (UFPEL. Foram capturados 43.945 Coleopteros das espécies Alphitobius diaperinus, Carcinops troglodytes, Euspilotus rubriculus, Gnathocerus cornutus, Mezium americanum e Somotrichus unifasciatus. Entre esses Coleopteros, Alphitobius diaperinus esteve presente em todos os meses do ano, com pico populacional de larvas em fevereiro (235 e menor índice de

  16. Interleukin-6-receptor polymorphisms rs12083537, rs2228145, and rs4329505 as predictors of response to tocilizumab in rheumatoid arthritis.

    Science.gov (United States)

    Enevold, Christian; Baslund, Bo; Linde, Louise; Josephsen, Norah L; Tarp, Ulrik; Lindegaard, Hanne; Jacobsen, Søren; Nielsen, Claus H

    2014-08-01

    Tocilizumab (TCZ), a monoclonal antibody targeting the human interleukin-6-receptor (IL-6R), is indicated for the treatment of rheumatoid arthritis (RA). We examined whether three IL6R single-nucleotide polymorphisms rs12083537, rs2228145 (formerly rs8192284), and rs4329505 with previously reported functional effects were associated with clinical response to TCZ in a retrospective study cohort consisting of 79 RA patients. Three months after initiation of TCZ therapy, changes in swollen joint count (SJC) and, subordinately, tender joint count (TJC), serum-CRP, DAS28-CRP, and EULAR-response were tested for association with the IL6R-haplotype or genotype. The major allele (A) of rs12083537 and the minor allele (C) of rs4329505 were associated with a poor SJC response (P=0.02 and 0.02, respectively). Moreover, the AAC-haplotype (for rs12083537, rs2228145, and rs4329505, respectively) was associated with a poor SJC response (P=0.00004) and, with borderline significance, EULAR-response (P=0.05). These data suggest that genetic variation in IL6R may aid in predicting TCZ therapy outcome in RA patients.

  17. Funcionalidad de la articulación glenohumeral en el golpe de drive en pelota a paleta

    OpenAIRE

    Doussouk, Karim; Doussouk, Adiel

    2013-01-01

    El propósito de esta ponencia, es realizar un análisis del gesto técnico denominado “Drive”, golpe determinante en la disciplina de Pelota a Paleta, a partir del estudio Anatómico y Biomecánico de la articulación Glenohumeral. Se destacará la importancia de los conocimientos anatomo-funcionales en la formación del Profesor en Educación Física, como base para el análisis del movimiento en cuestión, ya sea con fines de rendimiento deportivo o para mejorar la intervención docente. La articula...

  18. Characterization of Listeria monocytogenes isolated from a fresh mixed sausage processing line in Pelotas-RS by PFGE Caracterização de Listeria monocytogenes isoladas em uma linha de processamento de lingüiça mista frescal em Pelotas-RS por PFGE

    Directory of Open Access Journals (Sweden)

    Ana Eucares von Laer

    2009-09-01

    Full Text Available Listeria monocytogenes is a bacterium capable to adhere to the surfaces of equipment and utensils and subsequently form biofilms. It can to persist in the food processing environmental for extended periods of time being able to contaminate the final product. The aim of this study was to trace the contamination route of L. monocytogenes on a fresh mixed sausage processing line, from raw material to the final product. The isolates obtained were characterized by serotyping and molecular typing by pulsed-field gel electrophoresis (PFGE using the restriction enzymes ApaI and AscI. L. monocytogenes was detected in 25% of the samples. The samples of raw material were not contaminated, however, the microorganism was detected in 21% of the environmental samples (food contact and non-food contact, 20.8% of the equipments, 20% of the food worker's hands, 40% of the mass ready to packaging and in all the final products samples, demonstrating that the contamination of final product occurred during the processing and the importance of cross contamination. PFGE yielded 22 pulsotypes wich formed 7 clusters, and serotyping yielded 3 serotypes and 1 serogroup, however, the presence of serotypes 4b and 1/2b in the final product is of great concern for public health. The tracing of contamination showed that some strains are adapted and persisted in the processing environment in this industry.Listeria monocytogenes é uma bactéria com capacidade de formar biofilmes e de colonizar superfícies de equipamentos e utensílios. Esse microrganismo pode persistir por longos períodos em plantas de processamento de alimentos, sendo capaz de contaminar o produto final. O objetivo deste estudo foi traçar a rota de contaminação de L. monocytogenes em uma linha de processamento de lingüiça mista frescal, desde a matéria-prima até o produto final. Os isolados obtidos foram caracterizados por sorotipagem e por tipagem molecular, através de Pulsed Field Gel Electrophoresis (PFGE, usando as enzimas de restrição ApaI and AscI. L. monocytogenes foi detectada em 25% das amostras. Nenhuma amostra da matéria-prima apresentava o patógeno, entretanto, o microrganismo foi detectado em 21% das amostras ambientais (com e sem contato com o alimento, 20,8% dos equipamentos, 20% das amostras de mãos de manipuladores, 40% da massa pronta para o embutimento, e em todas as amostras do produto final. Isso demonstra que a contaminação do produto final ocorreu durante o processamento, e a importância da contaminação cruzada. PFGE produziu 22 pulsotipos e a sorotipagem produziu 3 sorotipos e 1 sorogrupo, entretanto, a presença dos sorotipos 4b e 1/2b no produto final é de grande importância para a saúde pública. Os perfis de macrorestrição mostraram que algumas cepas são adaptadas e persistiram no ambiente de processamento dessa indústria.

  19. Intensity-duration-frequency ratios obtained from annual records and partial duration records in the locality of Pelotas - RS, Brazil Relações intensidade-duração-frequência obtidas a partir de séries anual e de duração parcial para a localidade de Pelotas-RS

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    Claudia F. A. Teixeira

    2011-01-01

    Full Text Available The intensity-duration-frequency occurrence ratio (IDF is a tool commonly used for precipitation-runoff data transformation, which is established from observations of intense precipitations over a period sufficiently long as to allow the occurrence of extremes at the observation site. This study focused on verifying the existence or absence of new data, in terms of IDF ratio, by using partial duration records produced from data on maximum daily disaggregated rainfall for pre determined durations. The partial duration records considered a base value of 55 mm, totaling 279 values. After the rainfall series were established, their independence and seasonality were assessed. Using the Student's t-test statistics, it was established that no new data, as IDF ratio, emerged from the analysis of the partial duration series with the recommended base value of precipitation, as compared to the historical records.A relação intensidade-duração-frequência de ocorrência (IDF é uma ferramenta utilizada nos processos de transformação chuva-vazão, e sua determinação deve ser obtida a partir de observações de chuvas intensas, durante um período de tempo longo e representativo dos eventos extremos do local. O presente trabalho teve como objetivo verificar a existência ou não de ganho de informação, em termos de relação IDF, ao serem utilizadas séries de duração parcial, a partir dos dados de chuva máxima diária desagregada, em durações preestabelecidas. Quanto à série de duração parcial, foi utilizado o valor-base preestabelecido de 55 mm, constituindo então 279 valores. Posteriormente à constituição das séries de chuva, foi avaliada a independência e a estacionaridade dos valores contidos nas mesmas. Pela metodologia do teste "t" de Student, constatou-se que não há ganho de informação em termos de relação IDF quando utilizada a série de duração parcial, com o valor-base preestabelecido de precipitação, comparativamente à série de registros históricos.

  20. Association of EVI5 rs11808092, CD58 rs2300747, and CIITA rs3087456 polymorphisms with multiple sclerosis risk: A meta-analysis

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    Jiahe Liu

    2016-09-01

    Conclusions: The mutant alleles of EVI5 rs11808092 polymorphism may increase the susceptibility to MS while those of CD58 rs2300747 polymorphism may decrease MS risk. In addition, CIITA rs3087456 polymorphism might not be associated with MS.

  1. RS CV sub n binary systems

    Science.gov (United States)

    Linsky, J. L.

    1984-01-01

    An attempt is made to place in context the vast amount of data obtained as a result of X-ray, ultraviolet, optical, and microwave observations of RS CVn and similar spectroscopic binary systems. Emphasis is on the RS CVn systems and their long period analogs. The following questions are considered: (1) are the original defining characteristics still valid and still adequate? (2) what is the evidence for discrete active regions? (3) have any meaningful physical properties for the atmospheres of RS CVn systems been derived? (4) what do the flare observations tell about magnetic fields in RS CVn systems? (5) is there evidence for systematic trends in RS CVn systems with spectral type?

  2. The association between four genetic variants in microRNAs (rs11614913, rs2910164, rs3746444, rs2292832 and cancer risk: evidence from published studies.

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    Bangshun He

    Full Text Available MicroRNAs (miRNAs participate in diverse biological pathways and may act as either tumor suppressor genes or oncogenes. Single nucleotide polymorphisms (SNPs in miRNA may contribute to cancer development with changes in the microRNA's properties and/or maturation. Polymorphisms in miRNAs have been suggested in predisposition to cancer risk; however, accumulated studies have shown inconsistent conslusionss. To further validate determine whether there is any potential association between the four common SNPs (miR-196a2C>T, rs11614913; miR-146aG>C, rs2910164; miR-499A>G, rs3746444; miR-149C>T, rs2292832 and the risk for developing risk, a meta-analysis was performed according to the 40 published case-control studies. Odds ratios (ORs with 95% confidence intervals (CIs were calculated to assess the extent of the association. The results demonstrated that the rs11614913TT genotype was significantly associated with a decreased cancer risk, in particular with a decreased risk for colorectal cancer and lung cancer, or for Asian population subgroup. In addition, the rs2910164C allele was associated with decreased risk for esophageal cancer, cervical cancer, prostate cancer, and hepatocellular carcinoma (HCC, in particular in Asian population subgroup. Similarly, the rs3746444G allele was observed as a risk factor for cancers in the Asian population. It is concluded that two SNPs prsent in miRNAs(rs11614913TT, and rs2910164C may protect against the pathogenesis of some cancers, and that the rs3746444 may increase risk for cancer.

  3. Rs6454674, Rs806368 and Rs1049353 CNR1 Gene Polymorphisms in Turkish Bipolar Disorder Patients: A Preliminary Study

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    Gokay Alpak

    2014-04-01

    Full Text Available Bipolar disorder (BD is one of the most prevalent psychiatric disorders in clinical practice. The etiology of the BD is not thoroughly understood. Endocannabinoid system, which is involved in regulation of emotion, stress, memory, and cognition, may have an important role in the pathophysiology of BD. Mutations on the cannabinoid-1 receptor (CNR1 gene are associated with several psychiatric disorders. The main cannabinoid (CB receptor is CB1 and its activation inhibits neuronal depolarization. One previous study showed rs1049353 polymorphism of CNR1 gene is associated with major depression but not with BD. In this study, we aimed to investigate the rs6454674, rs806368 and rs1049353 CNR1 gene polymorphisms in Turkish BD patients. A total of 96 patients and 58 healthy controls were included in the current case-control study. Blood samples of study participants were collected into sterile tubes and processed to obtain genomic DNA. Restriction Fragment Length Polymorphism analysis were done by digesting the PCR products with HpyCH4III and BseGI enzymes for the rs6454674 and rs806368 restriction sites, respectively. Single-Strand Conformation Polymorphism (SSCP analysis was also performed. Among three polymorphisms investigated in this study, only rs6454674 polymorphism was significantly different between BD patients and controls (rs6454674 T/G; p=0.042, rs806368 T/C; p>0.05, rs1049353 A/G; p>0.05. Furthermore, we found that the mean of the yearly manic attacks was statistically higher in patients who have heterozygote (0.91+/-0.67 rs6454674 T/G polymorphisms compared to those with homozygote (p=0.043 polymorphism. The post-hoc analysis showed that the main differences were between the heterozygotes genotype and non-mutant (GG homozygotes (0.42+/-0.31; p=0.037 but not in homozygote mutant genotype (0.74+/-0.74; p=0.149. When patients were compared with the other clinical parameters, and mutated alleles and genotypes for each polymorphism, we did not

  4. Estudio experimental controlado y aleatorizado sobre la efectividad y seguridad del uso de la pelota de parto durante el trabajo de parto

    OpenAIRE

    Delgado García, Beatriz Elena

    2015-01-01

    La presente tesis fue financiada por el Fondo de Investigación Sanitarias del Instituto Carlos III, dependiente del Ministerio de Ciencia e Innovación, con el registro PI09/90257 y el proyecto de investigación titulado "Estudio experimental controlado y aleatorizado para evaluar la efectividad y seguridad del uso de la pelota de parto durante el trabajo del parto y el parto.

  5. Tabaco, álcool e outras drogas entre adolescentes em Pelotas, Rio Grande do Sul, Brasil: uma perspectiva de gênero Tobacco, alcohol, and drug use by teenagers in Pelotas, Rio Grande do Sul State, Brazil: a gender approach

    Directory of Open Access Journals (Sweden)

    Rogério Lessa Horta

    2007-04-01

    Full Text Available Este estudo teve o objetivo de examinar a relação entre gênero e utilização de substâncias psicoativas entre adolescentes (consumo de bebidas alcoólicas, fumo e uso de drogas ilícitas. Em 2002 foi realizado um estudo transversal na área urbana de Pelotas, extremo-sul do Brasil. Foi empregada amostragem em múltiplos estágios para se obter uma amostra de adolescentes entre 15 e 18 anos de idade. As entrevistas foram realizadas com questionário auto-aplicado. Tabagismo foi mais prevalente entre as meninas, enquanto o consumo de bebida alcoólica no mês anterior às entrevistas foi maior entre os meninos. Por outro lado, a proporção de adolescentes que relataram uso de drogas ilícitas no mês que antecedeu as entrevistas não esteve relacionada ao gênero. O maior consumo de tabaco entre meninas que entre meninos pode indicar risco de expansão do consumo desta substância por mulheres de outras faixas etárias em gerações futuras, o que justifica preocupação e esforços específicos.This study assesses the relationship between gender and use of psychoactive substances (alcohol, nicotine, and illicit drugs by teenagers. In 2002, a cross-sectional study was carried out in the urban area of Pelotas, southern Brazil. Multi-stage sampling was used to obtain a sample of adolescents, 15 to 18 years of age. Subjects were interviewed using a self-applied confidential questionnaire. Smoking was more prevalent among girls, while alcohol consumption in the previous month was more common among boys. Meanwhile, the proportion of adolescents that reported drug use in the previous month was unrelated to gender. Higher cigarette consumption by girls suggests an increase in smoking by women in the future, which highlights the need for a special focus on this area.

  6. Oral health follow-up studies in the 1993 Pelotas (Brazil birth cohort study: methodology and principal results Estudos de saúde bucal na coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993: metodologia e resultados principais

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    Marco A. Peres

    2010-10-01

    Full Text Available The aim of this study was to describe oral health follow-up studies nested in a birth cohort. A population-based birth cohort was launched in 1993 in Pelotas, Rio Grande do Sul State, Brazil. Two oral health follow-up studies were conducted at six (n = 359 and 12 (n = 339 years of age. A high response rate was observed at 12 years of age; 94.4% of the children examined at six years of age were restudied in 2005. The mean DMF-T index at age 12 was 1.2 (SD = 1.6 for the entire sample, ranging from 0.6 (SD = 1.1 for children that were caries-free at age six, 1.3 (SD = 1.5 for those with 1-3 carious teeth at six years, and 1.8 (SD = 1.8 for those with 4-19 carious teeth at six years (p O objetivo deste trabalho foi descrever estudos de saúde bucal em uma coorte de nascimentos. Em 1993, teve início uma coorte de nascimentos de base populacional em Pelotas, Rio Grande do Sul, Brasil. Dois estudos de saúde bucal aos 6 (n = 359 e 12 anos de idade (n = 339 foram realizados. Foi observada uma alta taxa de resposta no período entre 6 e 12 anos de idade; 94,4% das crianças pesquisadas em 1999 foram examinadas em 2005. A média do índice CPO-D aos 12 anos foi de 1,2 (DP = 1,6 para a população como um todo, variando de 0,6 (DP = 1,1 para o grupo livre de cáries aos 6 anos, 1,3 (DP = 1,5 para os que apresentaram 1-3 dentes atacados pela cárie e 1,8 (DP = 1,8 para aqueles com 4-19 dentes atacados pela cárie (p < 0,01. Observou-se um aumento da proporção de indivíduos com oclusopatias muito severas aos 12 anos, conforme o número de oclusopatias presentes aos 6 anos de idade. Problemas bucais no início da adolescência foram mais prevalentes nos indivíduos que apresentaram agravos à saúde bucal na infância.

  7. Qualidade do ambiente e fatores associados: um estudo em crianças de Pelotas, Rio Grande do Sul, Brasil Quality of the environment and associated factors: a pediatric study in Pelotas, Rio Grande do Sul, Brazil

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    Maria de Fátima Duarte Martins

    2004-06-01

    Full Text Available Descrever e identificar fatores que possam estar associados à qualidade do ambiente e características das crianças expostas, em Pelotas, Rio Grande do Sul, Brasil. Trata-se de um estudo prospectivo de caráter populacional, incluindo 630 crianças da coorte de nascimentos de 1993. No ano de 1998 avaliou-se, entre outras informações, a qualidade do ambiente, medida através do Home Observation for the Measurement of the Environment. Os dados foram analisados por meio de análise univariada. A associação entre as variáveis e o desfecho foi avaliada por meio das razões de prevalência, dos intervalos de confiança em 95% e do qui-quadrado. Realizou-se a regressão logística seguindo modelo hierarquizado. Constatou-se que 97 crianças (15% viviam em ambiente negativo. Encontraram-se oito fatores de risco associados à qualidade do ambiente: baixa renda familiar mensal, baixa escolaridade materna, sexo masculino, casas com mais de sete residentes, número de irmãos maior ou igual a quatro, uso de tabaco na gestação, crianças que dormem na cama dos pais aos 4 anos e mães com presença de transtornos psiquiátricos.This study aims to describe and identify factors associated with environmental quality and characteristics of children exposed to environmental risk factors in Pelotas, Rio Grande do Sul, Brazil. This was a prospective, population-based study, including 630 children from the 1993 birth cohort. During the year 1998, environmental quality and other information were assessed using the Home Observation for the Measurement of the Environment. Data were submitted to univariate analysis. The association between the variables and the outcome was evaluated through prevalence ratios, 95% confidence intervals, and chi-square. Logistic regression was performed according to a hierarchical model. Some 97 children (15% were living in negative environments. Eight risk factors were associated with environmental quality: low monthly family

  8. Nutritional status of adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Estado nutricional de adolescentes: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

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    Cora Luiza Araújo

    2010-10-01

    Full Text Available We evaluate the influence of demographic, socioeconomic, and maternal variables on the nutritional status of adolescents aged 11 years. We conducted a prospective cohort study including 4,452 adolescents born in Pelotas, Southern Brazil, in 1993, accounting for 87.5% of the original cohort. Nutritional status was evaluated based on World Health Organization criteria. Subjects were classified according to nutritional status into thin, normal, overweight and obese. Independent variables analyzed included skin color, socioeconomic status, maternal schooling, and maternal body mass index (BMI. Analyses were stratified by sex, and multivariable regression was performed using the multinomial logistic approach. Overall, 7% of adolescents were classified as thin, 11.6% as overweight, and 11.6% as obese. Among boys, thinness was inversely associated with maternal schooling and maternal BMI. Among girls, thinness was directly associated with maternal BMI. Overweight and obesity were directly associated with socioeconomic status and maternal BMI, the former showing the strongest association with nutritional status among adolescents.O objetivo deste estudo foi avaliar a influência de fatores demográficos, sócioeconômicos e maternos sobre o estado nutricional de adolescentes, nascidos em 1993, em Pelotas, Rio Grande do Sul, Brasil. A amostra estudada (n = 4.452 representa 87,5% da coorte original. O estado nutricional foi avaliado conforme as recomendações da Organização Mundial da Saúde, categorizado em magro, eutrófico, sobrepeso e obeso. As variáveis independentes foram cor da pele, índice de bens, escolaridade e índice de massa corporal (IMC maternos. As análises foram estratificadas por sexo, e a regressão logística multinomial foi usada. Ao todo, 7% dos adolescentes eram magros, 11,6% tinham sobrepeso e 11,6% eram obesos. Entre os meninos, a prevalência de adolescentes magros apresentou associação inversa com escolaridade e IMC

  9. Auto-estima e fatores associados em gestantes da cidade de Pelotas, Rio Grande do Sul, Brasil Self-esteem and associated factors in pregnant women in the city of Pelotas, Rio Grande do Sul State, Brazil

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    Michelle de Souza Dias

    2008-12-01

    Full Text Available O estudo tem como objetivo mensurar a auto-estima e fatores associados em gestantes atendidas pelo Sistema Único de Saúde (SUS na cidade de Pelotas, Rio Grande do Sul, Brasil. É do tipo transversal, tendo-se entrevistado 560 gestantes nos meses de maio a novembro de 2006, nos ambulatórios e enfermarias dos hospitais universitários e do centro de atendimento da Prefeitura Municipal. Dentre as gestantes atendidas, 62,9% receberam o diagnóstico de alto-risco. Para avaliação da auto-estima foi utilizada a escala de Rosenberg. Na amostra total a média de pontos na escala foi de 9,2 e o desvio-padrão de 4,6. As variáveis associadas positiva e significativamente com auto-estima foram idade, nível de escolaridade e nível econômico. Já as variáveis percepção de risco à saúde do bebê e número de gestações mostraram-se associadas negativamente à auto-estima. Além disso, as gestantes com condição gestacional de alto-risco têm uma auto-estima mais elevada quando comparadas com as de baixo-risco.This study analyzes self-esteem and associated factors in pregnant women treated by the Unified National Health System (SUS in the city of Pelotas, Rio Grande do Sul State, Brazil. Using a cross-sectional design, 560 pregnant women were interviewed from May to November 2006. The interviews were held in specific locations like University outpatient clinics and hospital wards and a center run by the city government. A full 62.9% were diagnosed as high-risk pregnancies. Mean self-esteem according to the Rosenberg scale was 9.2 (SD = 4.6. Variables showing a positive, significant association with self-esteem were age, schooling, and income. Perception of risk to the unborn infant's health and parity were both negatively associated with maternal self-esteem. These high-risk pregnant women also showed higher self-esteem than low-risk pregnant women.

  10. Prevalence of suicide risk and comorbidities in postpartum women in Pelotas Prevalência do risco de suicídio e de comorbidades em mulheres pós-parto em Pelotas

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    Daniele Tavares

    2012-10-01

    Full Text Available OBJECTIVES: To evaluate the prevalence of suicide risk and comorbidities in postpartum women. METHODS: This is a cross-sectional study of postpartum women. The sample comprised mothers who have received prenatal care from the Brazilian National System of Public Heath in the city of Pelotas. Suicide risk and other mental disorders were evaluated using the Mini International Neuropsychiatric Interview (MINI. A yes answer on one of the six interview questions was considered a sign of suicide risk. RESULTS: The sample consisted of 919 postpartum women. The 11.5% suicide prevalence was 4.62 (CI 2.45, 8.73 times higher in women with low educational levels. Women with comorbid depression or an anxiety disorder showed a 17.04 (CI 2.27; 19.96 times greater risk of suicide than those who did not suffer from any mood disorder. CONCLUSION: Lower education levels and psychiatric disorders are associated with suicide risk. Bipolar disorder is the psychiatric disorder with the highest impact on suicide risk.OBJETIVOS: Avaliar a prevalência do risco de suicídio e de comorbidades em mulheres pós-parto. MÉTODOS: Este foi um estudo em corte transversal com mulheres pós-parto. A amostra foi constituída de mães que receberam cuidados pré-natais prestados pelo Sistema Nacional de Saúde Pública do Brasil na cidade de Pelotas. O risco de suicídio e outros transtornos mentais foram avaliados pela Mini International Neuropsychiatric Interview (MINI. Uma resposta afirmativa a qualquer das seis perguntas é considerada um risco de suicídio. RESULTADOS: A amostra consistiu de 919 mulheres pós-parto. A prevalência do risco de suicídio foi de 11,5%. Ela foi 4,62 vezes mais alta (IC de 95% 2,45; 8,73 em mulheres de baixo nível educacional. Mulheres apresentando qualquer comorbidade para depressão e transtornos ansiosos tiveram uma chance 17,04 vezes maior (IC 95% 2,27; 19,96 àquelas que não apresentaram nenhum transtorno afetivo. CONCLUSÃO: Um n

  11. Adesão à terapêutica da tuberculose em Pelotas, Rio Grande do Sul: na perspectiva do paciente Tuberculosis treatment adherence in Pelotas, Brazil, from the patient's perspective

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    Helen Gonçalves

    1999-10-01

    Full Text Available O trabalho aborda a adesão ao tratamento da tuberculose dentro do universo composto por homens e mulheres doentes e as conexões e conseqüências da doença na seu modo/fase de vida e no resultado final do tratamento. O estudo etnográfico, como um sub-estudo do Projeto Controle Epidemiológico da Tuberculose na Cidade de Pelotas, Rio Grande do Sul, propunha-se, inicialmente, verificar as razões existentes para que os pacientes não completassem o tratamento. Utilizou-se o método etnográfico de observação direta, conjugado com as entrevistas semi-estruturadas. A opção pela utilização do termo adesão é justificada pela preocupação em abranger outros fatores fundamentais, além da responsabilidade individualizada do enfermo. Esta abordagem possibilitou compreender as concepções de doença, as dinâmicas sociais entre os diversos protagonistas envolvidos no processo da doença e seu tratamento. Levaram-se em consideração alguns dos fatores implicados na adesão ao tratamento: características sócio-demográficas, fatores culturais, crenças populares, relação de custo benefício, aspectos físicos e químicos dos medicamentos, interação médico paciente e grau de participação familiar no tratamento.This study deals with adherence to tuberculosis treatment among men and women as well as the disease's links and consequences vis-à-vis life styles and treatment outcomes. The ethnographic study was a component of the Tuberculosis Epidemiological Control Project in the city of Pelotas and aimed to identify the reasons patients failed to complete treatment. Direct ethnographic observations and semi-structured interviews were used. Use of the term "adherence" is justified by the concern for extending to other fundamental factors in addition to the patient's own individual responsibility. This approach fostered an understanding of views towards disease, social dynamics among the various protagonists involved in the disease process

  12. Comparison of Vaisala radiosondes RS41 and RS92 at the ARM Southern Great Plains site

    Science.gov (United States)

    Jensen, Michael P.; Holdridge, Donna J.; Survo, Petteri; Lehtinen, Raisa; Baxter, Shannon; Toto, Tami; Johnson, Karen L.

    2016-07-01

    In the fall of 2013, the Vaisala RS41 (fourth generation) radiosonde was introduced as a replacement for the RS92-SGP radiosonde with improvements in measurement accuracy of profiles of atmospheric temperature, humidity, and pressure. In order to help characterize these improvements, an intercomparison campaign was undertaken at the US Department of Energy's Atmospheric Radiation Measurement (ARM) Climate Research Facility site in north-central Oklahoma, USA. During 3-8 June 2014, a total of 20 twin-radiosonde flights were performed in a variety of atmospheric conditions representing typical midlatitude continental summertime conditions. The results show that for most of the observed conditions the RS92 and RS41 measurements agree much better than the manufacturer-specified combined uncertainties with notable exceptions when exiting liquid cloud layers where the "wet-bulbing" effect appears to be mitigated for several cases in the RS41 observations. The RS41 measurements of temperature and humidity, with applied correction algorithms, also appear to show less sensitivity to solar heating. These results suggest that the RS41 does provide important improvements, particularly in cloudy conditions. For many science applications - such as atmospheric process studies, retrieval development, and weather forecasting and climate modeling - the differences between the RS92 and RS41 measurements should have little impact. However, for long-term trend analysis and other climate applications, additional characterization of the RS41 measurements and their relation to the long-term observational records will be required.

  13. Environment sensitivity map to North Pelotas Basin: subsidy to elaboration of contingency plans; Mapeamento da sensibilidade ambiental para a porcao norte da Bacia de Pelotas: subsidio para elaboracao de planos de contingencia

    Energy Technology Data Exchange (ETDEWEB)

    Diniz, Debora P.; Griep, Gilberto H. [Fundacao Universidade do Rio Grande (FURG), RS (Brazil)

    2008-07-01

    The Pelotas Basin stands out in the national scenery of search of petroleum and gas. Due of these interests they become important environmental protection actions. Inside of this panorama is the Chart of Sensitivity Index (CSI). The study was developing in Santa Catarina, municipal districts from Passo de Torres to Palhoca. The objectives of this work were the development of the CSI and the construction of a bibliographical database. The methodology used in this work was proposed by the Ministerio do Meio Ambiente. During the field exit sediment samples, photographic registration and pertinent observation were collected. With all this information the Index of Environment Sensitivity (IES) was generated, that classifies the coasts in agreements with the sensitivity to the oil. Diversity of environments is very clear at this coast for the variability of the IES. The most frequent ecosystem is beaches of medium to fine sand exposed. It was identified the presence of environments of highly sensitive, classified in the index 8 and 10. The definition of possible scarification areas was accomplishments with IES, biological resources and economical partner of the area. (author)

  14. Methods and logistics of a multidisciplinary survey of schoolchildren from Pelotas, in the Southern Region of Brazil Métodos y logística de un estudio multidisciplinar con escolares de Pelotas, sur de Brasil Métodos e logística de um estudo multidisciplinar com escolares de Pelotas, Sul do Brasil

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    Marlos Rodrigues Domingues

    2013-05-01

    Full Text Available This paper describes the methods of a multidisciplinary epidemiological survey conducted in schools in Pelotas, in the Southern Region of Brazil. This cross-sectional study evaluated a representative sample (n = 1,211 of eight to 12-year-old children attending public (15 and private (5 schools. Questionnaires were applied to parents to obtain information about socioeconomic and sociocultural characteristics. Children were interviewed to provide information on demographic characteristics, oral health behavior and physical activity habits. Oral health examinations were performed on the children and anthropometric data was collected to assess nutritional status. School principals responded a questionnaire about the social and physical environment of the school. A total of 1,744 children were eligible for the study; a response rate of 69.4% was achieved, with no significant differences between schools. The method used allowed investigators to obtain data on several health outcomes as well as on possible risk factors. This strategy optimizes the use of financial resources for research and promotes interprofessional collaboration.El artículo detalla los métodos de un estudio epidemiológico multidisciplinar llevado a cabo en escuelas en Pelotas, sur de Brasil. El estudio transversal incluyó una muestra representativa (n = 1.211 de niños de 8 a 12 años, en escuelas públicas (15 y privadas (5. Los cuestionarios fueron administrados a los padres para obtener información socioeconómica y cultural. Los niños fueron entrevistados, proporcionando información demográfica, comportamientos de salud bucal y práctica de actividad física. Se realizaron un examen de salud bucal y medidas antropométricas para la evaluación de la condición nutricional. Directores de escuelas proporcionaron información sobre el ambiente físico y social de las escuelas. De los 1.744 niños elegibles, la tasa de respuesta fue de un 69,4% sin diferencias entre escuelas

  15. Feeding of Cyphocharax voga (Hensel, 1869 (Characiformes, Curimatidae in Corrientes Stream, Pelotas, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Sergio Renato Noguez Piedras

    2008-12-01

    Full Text Available The Cyphocharax voga species is distributed from the hydrographic basin of the Paraguay River and lower Paraná up to the coastal hydrographic systems of South America. Corrientes stream sets the boundary between Turuçu and Pelotas counties and has not been a focus of detailed studies so far. The aim of this paper was to study the C. voga feeding process for a better understanding of its diet at the site. Thirty-two specimens were collected between December and March 2005, packed in ice-covered boxes and taken to the laboratory. The diet was analyzed by methods of occurrence frequency and relative frequency; for both males and females, total, average and standard deviation were registered; student's t-test and the q-square χ2 test were applied for ingested items. A total of 18 feeding categories were identified, including a 100% presence of filamentary algae and sediment. The prevalence of these items alongside with microorganisms associated with the feeding process makes this an iliophagous species in this environment. Meaningful differences in feeding between male and female specimens were not found through q-square χ2 test.

  16. Oral health follow-up studies in the 1993 Pelotas (Brazil) birth cohort study: methodology and principal results

    Science.gov (United States)

    Peres, Marco A.; Barros, Aluísio Jardim; Peres, Karen Glazer; Araújo, Cora Luiza; Menezes, Ana M. B.; Hallal, Pedro C.; Victora, Cesar G.

    2013-01-01

    The aim of this study was to describe oral health follow-up studies nested in a birth cohort. A population-based birth cohort was launched in 1993 in Pelotas, Rio Grande do Sul State, Brazil. Two oral health follow-up studies were conducted at six (n = 359) and 12 (n = 339) years of age. A high response rate was observed at 12 years of age; 94.4% of the children examined at six years of age were restudied in 2005. The mean DMF-T index at age 12 was 1.2 (SD = 1.6) for the entire sample, ranging from 0.6 (SD = 1.1) for children that were caries-free at age six, 1.3 (SD = 1.5) for those with 1-3 carious teeth at six years, and 1.8 (SD = 1.8) for those with 4-19 carious teeth at six years (p < 0.01). The number of individuals with severe malocclusions at 12 years was proportional to the number of malocclusions at six years. Oral health problems in early adolescence were more prevalent in individuals with dental problems at six years of age. PMID:20963297

  17. Nutritional status of adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil) birth cohort study

    Science.gov (United States)

    Araújo, Cora Luiza; Dumith, Samuel C.; Menezes, Ana M. B.; Hallal, Pedro C.; Vieira, Maria de Fátima A.; Madruga, Samanta W.; Victora, Cesar G.

    2013-01-01

    We evaluate the influence of demographic, socioeconomic, and maternal variables on the nutritional status of adolescents aged 11 years. We conducted a prospective cohort study including 4,452 adolescents born in Pelotas, Southern Brazil, in 1993, accounting for 87.5% of the original cohort. Nutritional status was evaluated based on World Health Organization criteria. Subjects were classified according to nutritional status into thin, normal, overweight and obese. Independent variables analyzed included skin color, socioeconomic status, maternal schooling, and maternal body mass index (BMI). Analyses were stratified by sex, and multivariable regression was performed using the multinomial logistic approach. Overall, 7% of adolescents were classified as thin, 11.6% as overweight, and 11.6% as obese. Among boys, thinness was inversely associated with maternal schooling and maternal BMI. Among girls, thinness was directly associated with maternal BMI. Overweight and obesity were directly associated with socioeconomic status and maternal BMI, the former showing the strongest association with nutritional status among adolescents. PMID:20963286

  18. COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study

    Science.gov (United States)

    Salatino-Oliveira, Angélica; Murray, Joseph; Kieling, Christian; Genro, Júlia Pasqualini; Polanczyk, Guilherme; Anselmi, Luciana; Wehrmeister, Fernando; de Barros, Fernando C.; Menezes, Ana Maria Baptista; Rohde, Luis Augusto; Hutz, Mara Helena

    2016-01-01

    Conduct problems in childhood and adolescence are significant precursors of crime and violence in young adulthood. The purpose of the current study is to test the interaction between prenatal maternal smoking and COMT Val158Met in conduct problems and crime in the 1993 Pelotas Birth Cohort Study. Conduct problems were assessed through the parent version of the Strengths and Difficulties Questionnaire at ages 11 and 15 years. A translated version of a confidential self-report questionnaire was used to collect criminal data at 18 years of age. Negative binomial regression analyses showed an association between prenatal maternal smoking and SDQ conduct problem scores (IRR = 1.24; 95% CI: 1.14–1.34; p < 0.001) at 11 years of age. However, no evidence was found for an association between COMT genotypes and conduct scores or for an interaction between maternal smoking and this gene in predicting conduct problems. Very similar results were obtained using the 15 years conduct scores and crime measure at age 18. Prenatal maternal smoking was associated with crime (IRR = 1.28; 95% CI: 1.09–1.48; p = 0.002) but neither COMT genotypes nor the possible interaction between gene and maternal smoking were significantly associated with crime. Replications of GxE findings across different social contexts are critical for testing the robustness of findings. PMID:27426045

  19. Maternal anthropometric characteristics in pregnancy and blood pressure among adolescents: 1993 live birth cohort, Pelotas, southern Brazil

    Directory of Open Access Journals (Sweden)

    Hallal Pedro C

    2010-07-01

    Full Text Available Abstract Background We investigated the association between maternal anthropometric measurements in prepregnancy and at the end of pregnancy and their children's systolic (SBP and diastolic (DBP blood pressure at 11 years of age, in a prospective cohort study. Methods All hospital births which took place in 1993 in the city of Pelotas - Brazil, were identified (5,249 live births. In 2004, the overall proportion of follow-up was 85% and we obtained arterial blood pressure measurements of 4,452 adolescents. Results Independent variables analyzed included maternal prepregnancy weight and body mass index (BMI and maternal weight, and height at the end of pregnancy. Multiple linear regression analysis controlling for the following confounders were carried out: adolescent's skin color, family income at birth, smoking, alcohol intake during pregnancy, and gestational arterial hypertension. Mean SBP and DBP were 101.9 mmHg (SD 12.3 and 63.4 mmHg (SD 9.9, respectively. Maternal prepregnancy weight and BMI, and weight at the end of pregnancy were positively associated with both SBP and DBP in adolescent subjects of both sexes; maternal height was positively associated with SBP only among males. Conclusions Adequate evaluation of maternal anthropometric characteristics during pregnancy may prevent high levels of blood pressure among adolescent children.

  20. COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study.

    Science.gov (United States)

    Salatino-Oliveira, Angélica; Murray, Joseph; Kieling, Christian; Genro, Júlia Pasqualini; Polanczyk, Guilherme; Anselmi, Luciana; Wehrmeister, Fernando; de Barros, Fernando C; Menezes, Ana Maria Baptista; Rohde, Luis Augusto; Hutz, Mara Helena

    2016-01-01

    Conduct problems in childhood and adolescence are significant precursors of crime and violence in young adulthood. The purpose of the current study is to test the interaction between prenatal maternal smoking and COMT Val(158)Met in conduct problems and crime in the 1993 Pelotas Birth Cohort Study. Conduct problems were assessed through the parent version of the Strengths and Difficulties Questionnaire at ages 11 and 15 years. A translated version of a confidential self-report questionnaire was used to collect criminal data at 18 years of age. Negative binomial regression analyses showed an association between prenatal maternal smoking and SDQ conduct problem scores (IRR = 1.24; 95% CI: 1.14-1.34; p age. However, no evidence was found for an association between COMT genotypes and conduct scores or for an interaction between maternal smoking and this gene in predicting conduct problems. Very similar results were obtained using the 15 years conduct scores and crime measure at age 18. Prenatal maternal smoking was associated with crime (IRR = 1.28; 95% CI: 1.09-1.48; p = 0.002) but neither COMT genotypes nor the possible interaction between gene and maternal smoking were significantly associated with crime. Replications of GxE findings across different social contexts are critical for testing the robustness of findings. PMID:27426045

  1. Transtornos mentais comuns e qualidade de vida em jovens: uma amostra populacional de Pelotas, Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Karen Jansen

    2011-03-01

    Full Text Available O objetivo foi verificar a prevalência de transtornos mentais comuns (TMC e sua associação com qualidade de vida em jovens da cidade de Pelotas, Rio Grande do Sul, Brasil. Estudo transversal de base populacional com jovens de 18 a 24 anos. A seleção amostral foi realizada por conglomerados. Para a investigação dos transtornos mentais comuns foi aplicado o Self Report Questionnaire (SRQ-20, enquanto os níveis de qualidade de vida foram mensurados por intermédio da Medical Outcomes Survey Short-form General Health Survey (SF-36. A prevalência de TMC na amostra estudada foi de 24,5% (N = 382, apresentando-se mais evidente entre as mulheres, entre aqueles que pertenciam à menor classe socioeconômica (D ou E, não estavam estudando, não estavam trabalhando, consumiram álcool e usaram tabaco pelo menos uma vez na última semana e que fizeram uso de alguma substância ilícita nos últimos três meses. Os jovens com TMC obtiveram uma menor média nos escores da SF-36 em todos os domínios de qualidade de vida avaliados. Deve-se investir em medidas preventivas de TMC no intuito de proporcionar uma melhor qualidade de vida à população.

  2. Fatores de risco para diabetes mellitus gestacional na coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 2004 Risk factors for gestational diabetes mellitus in the birth cohort in Pelotas, Rio Grande do Sul State, Brazil, 2004

    Directory of Open Access Journals (Sweden)

    Maria Alice Souza de Oliveira Dode

    2009-05-01

    Full Text Available Consensos de diversos países referem idade, obesidade e história familiar de diabetes mellitus como fatores de risco para diabetes mellitus gestacional. Outros fatores permanecem controversos. O objetivo deste estudo foi investigar fatores associados ao diabetes mellitus gestacional entre mães dos recém-nascidos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, em 2004. Foram entrevistadas 4.243 puérperas no hospital, havendo 0,5% de recusas. O diagnóstico de diabetes mellitus gestacional foi auto-referido. A prevalência de diabetes mellitus gestacional foi 2,95% (IC95%: 2,53-3,64. Análise bruta realizada por meio de testes qui-quadrado mostrou associação direta com aumento da idade, escolaridade, nível econômico e índice de massa corporal (IMC e inversa com altura materna. Cor não branca, história familiar de diabetes mellitus, tabagismo no primeiro e segundo trimestres e atividade física antes da gestação e no primeiro trimestre mostraram-se associados. A análise ajustada hierarquizada realizada através de regressão logística mostrou associação com maior idade, cor não branca, maior escolaridade, história familiar de diabetes mellitus e maior IMC. A altura ficou no limiar da significância. Tabagismo no primeiro e segundo trimestres foi protetor.Consensus statements by various countries have reported age, obesity, and family history of diabetes mellitus as risk factors for gestational diabetes mellitus. Other factors remain controversial. The aim of this study was to investigate factors associated with gestational diabetes among mothers of newborns from the birth cohort in Pelotas, Rio Grande do Sul State, Brazil, in 2004. We interviewed 4,243 postpartum women in hospital, with a 0.5% refusal rate. Diagnosis of gestational diabetes was self-reported. Prevalence of gestational diabetes was 2.95% (95%CI: 2.53-3.64. Crude analysis using the chi-square test showed a direct association with age, schooling

  3. Determinants of preterm birth: Pelotas, Rio Grande do Sul State, Brazil, 2004 birth cohort Determinantes de nascimento pré-termo na coorte de nascimentos de 2004, Pelotas, Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Mariângela F. Silveira

    2010-01-01

    Full Text Available Prematurity is a leading cause of neonatal mortality and a global health problem that affects high, middle and low-income countries. Several factors may increase the risk of preterm birth. In this article, we test the hypothesis that different risk factors determine preterm birth in different income groups by investigating whether risk factors for preterm deliveries in the 2004 Pelotas (Rio Grande do Sul State, Brazil birth cohort vary among those groups. A total of 4,142 women were included in the analysis. Preterm births were equally common among women who had spontaneous vaginal deliveries as for those with induced or operative births. In the multivariate analysis the factors that remained significantly associated with preterm birth were black skin color, low education, poverty, young maternal age, primiparity, previous preterm birth, inadequacy of prenatal care and reported hypertension. In the analyses repeated after stratification by family income terciles, there was no evidence of effect modification by income and no clear difference between the socioeconomic groups. No association between cesarean section and preterm delivery was found. Further studies are required to understand the causes of the epidemic of preterm births in Brazil.A prematuridade é uma grande causa de morte neonatal e um problema de saúde global, afetando países de alta, média e baixa renda. Vários fatores podem aumentar o risco de parto pré-termo. Neste artigo, testamos a hipótese de que diferentes fatores de risco determinem o parto pré-termo em diferentes grupos de renda, investigando como fatores de risco para prematuridade na coorte de nascimentos de 2004 de Pelotas, Rio Grande do Sul, Brasil, variam entre estes grupos. Foram incluídas na análise 4.142 mulheres. Os nascimentos pretermo foram igualmente comuns entre mulheres com partos vaginais e com partos induzidos ou cesáreas. Na análise multivariada, a cor negra, baixa educação, baixa renda, idade

  4. RS-84 Engine Completes Design Review

    Science.gov (United States)

    2003-01-01

    This is an artist's concept of the kerosene-fueled RS-84 engine, one of several technologies competing to power NASA's next generation of launch vehicles. The RS-84 has successfully completed its preliminary design review as a reusable, liquid kerosene booster engine that will deliver a thrust level of 1 million pounds of force. The preliminary design review is a lengthy technical analysis that evaluates engine design according to stringent system requirements. The review ensures development is on target to meet Next Generation Launch Technology goals: Improved safety, reliability, and cost.

  5. PELOTAS,“CIDADE DE GAYS”: Um estudo sobre os usos políticos de uma representação

    Directory of Open Access Journals (Sweden)

    Gláucia Cavalheiro

    2012-09-01

    Full Text Available Esteartigo é um resumo da monografia apresentada para a conclusão do Curso de Pós-Graduação em Memória, Identidade e Cultura Material, do Instituto de Ciências Humanas da Universidade Federal de Pelotas, tendo como banca examinadora os professores Dra. Maria Letícia Mazzuchi Ferreira, Me. Edgar Rodrigues Barbosa (orientador e Dra. Flávia Rieth (co-orientadora, aos quais expresso meus profundos agradecimentos

  6. Food intake profiles of children aged 12, 24 and 48 months from the 2004 Pelotas (Brazil) birth cohort: an exploratory analysis using principal components

    OpenAIRE

    Gatica Giovanna; Barros Aluisio J D; Madruga Samanta; Matijasevich Alicia; Santos Iná S

    2012-01-01

    Abstract Objectives To identify food intake profiles of children during their first four years of life and assess its variations according to sociodemographic and behavioral characteristics. Methods The Pelotas Birth Cohort Study (Brazil) recruited 4,231 liveborns, who were followed-up at ages 3, 12, 24 and 48 months. Food consumption data of children aged 12, 24 and 48 months was collected using a list of foods consumed during a 24-hour period prior to the interview. The food profiles were i...

  7. Soft-decision decoding of RS codes

    DEFF Research Database (Denmark)

    Justesen, Jørn

    2005-01-01

    By introducing a few simplifying assumptions we derive a simple condition for successful decoding using the Koetter-Vardy algorithm for soft-decision decoding of RS codes. We show that the algorithm has a significant advantage over hard decision decoding when the code rate is low, when two or more...

  8. Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China.

    Science.gov (United States)

    Gao, Kaiping; Wang, Jinjin; Li, Linlin; Zhai, Yujia; Ren, Yongcheng; You, Haifei; Wang, Bingyuan; Wu, Xuli; Li, Jianna; Liu, Zichen; Li, Xiong; Huang, Yaxin; Luo, Xin-Ping; Hu, Dongsheng; Ohno, Kinji; Wang, Chongjian

    2016-03-01

    Genetic variants at KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963 have been associated with type 2 diabetes mellitus (T2DM), but the results are contradictory in Chinese populations. The aim of the present study was to investigate the association of these four SNPs with T2DM in a large population of Han Chinese at Henan province, China. Seven-hundred-thirty-six patients with T2DM (cases) and Seven-hundred-sixty-eight healthy glucose-tolerant controls were genotyped for KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963. The association of genetic variants in these four genes with T2DM was analyzed using multivariate logistic regression. Genotypes and allele distributions of KCNQ1 rs151290 were significantly different between the cases and controls (p KLF14 rs972283, GCKR rs780094 or MTNR1B rs10830963 and T2DM were detected. The AC and CC genotypes and the C allele of rs151290 in KCNQ1 may be risk factors for T2DM in Han Chinese in Henan province. PMID:26927145

  9. Desempeño laboratorial de las unidades de atención primaria en el diagnóstico de tuberculosis en Pelotas, Brasil

    Directory of Open Access Journals (Sweden)

    Dagoberta Alves Vieira Beduhn

    2013-10-01

    Full Text Available Con el objetivo de evaluar el desempeño laboratorial de las unidades de atención primaria (UAP en el diagnóstico de tuberculosis por baciloscopía en Pelotas, Brasil, se realizó un estudio descriptivo en el cual se incluyó todas las baciloscopías solicitadas en once UAP entre 2007 y 2010. Para la evaluación del desempeño laboratorial se cuantificó el número de baciloscopías solicitadas y el tiempo entre la solicitud y la lectura de la lámina de examen en el laboratorio de referencia. Se encontraron 477 solicitudes registradas en las UAP. De ese total, apenas 51,8% fueron encontradas en el libro de registro del laboratorio, el desempeño más bajo fue de 24,2% y el más alto de 71,4%. Se identificó, en relación al tiempo de lectura de las láminas, que el 27,7% de las lecturas demoraban 8 días o más. Se concluye que las UAP evaluadas de la ciudad de Pelotas tienen un bajo desempeño laboratorial en el diagnóstico de TB por baciloscopías.

  10. Desempeño laboratorial de las unidades de atención primaria en el diagnóstico de tuberculosis en Pelotas, Brasil

    Directory of Open Access Journals (Sweden)

    Dagoberta Alves Vieira Beduhn

    2013-12-01

    Full Text Available Con el objetivo de evaluar el desempeño laboratorial de las unidades de atención primaria (UAP en el diagnóstico de tuberculosis por baciloscopía en Pelotas, Brasil, se realizó un estudio descriptivo en el cual se incluyó todas las baciloscopías solicitadas en once UAP entre 2007 y 2010. Para la evaluación del desempeño laboratorial se cuantificó el número de baciloscopías solicitadas y el tiempo entre la solicitud y la lectura de la lámina de examen en el laboratorio de referencia. Se encontraron 477 solicitudes registradas en las UAP. De ese total, apenas 51,8% fueron encontradas en el libro de registro del laboratorio, el desempeño más bajo fue de 24,2% y el más alto de 71,4%. Se identificó, en relación al tiempo de lectura de las láminas, que el 27,7% de las lecturas demoraban 8 días o más. Se concluye que las UAP evaluadas de la ciudad de Pelotas tienen un bajo desempeño laboratorial en el diagnóstico de TB por baciloscopías.

  11. PADRÃO BIOMÉTRICO DOS CAVALOS DE TRAÇÃO DA CIDADE DE PELOTAS NO RIO GRANDE DO SUL

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Wayne Nogueira

    2013-06-01

    Full Text Available Many families use wagon pulled by traction horses as their means of work or supplemental income. In Pelotas, there has been a Veterinary Clinic since 2006, which provides free weekly clinical care to these horses, due to concern about their health. The objectives of this study were to evaluate and record the biometric patterns of traction horses in Pelotas. We evaluated 219 horses, 129 females and 90 males. We measured chest width (ChW, leg perimeter (LP, thoracic perimeter (TP, croup width (CrW, height (H and weight (W of the animal. Through these values, we calculated the compactness index 1 (CCI1=(W/WH/100, compactness index 2 (CCI2 = (W/[WH-1]/100 and conformation index (CFI=TP2/WH. The animals of both sexes showed the following averages: H - 1.38 ± 0.07 m; LP - 0.19 ± 0.02 cm; TP - 1.56 ± 0.10 m; ChW - 0.26 ± 0.05 cm; CrW - 0.22 ± 0.05 cm; weight - 308 ± 60 kg. Regarding the ICC1, ICC2 and ICF indices, the averages for both sexes were, respectively: 2.30; 8.39; 1.82. Accordingly, the indices obtained showed that most of the evaluated horses were inadequate to pull heavy loads and had greater ability to pull light loads or to be used as riding horses.

  12. Roadkill of wild mammals on RS-135

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    Carla Grasiele Zanin Hegel

    2012-06-01

    Full Text Available Among environmental impacts, fragmentation of habitat for agriculture and livestock has led to a distortion of the natural environment and increased rates of wildlife killed on roads. Weekly surveys of road-killed mammals were made along highway RS-135 (km 8-34 between May 2008 and May 2010. For each case, we recorded the species and location along the road. We collected 95 mammals belonging to 16 species and 12 families, with a frequency of 0.025 roadkills per kilometer. The most abundant species were Cerdocyon thous (22.11%, Nasua nasua (10.52%, Pseudalopex gymnocercus (9.47% and Cavia aperea (7.37%, which together comprised 49.5% of the cases. This study contributed with information on roadkill of wild mammals in RS-135 of Rio Grande do Sul.

  13. A diphoton resonance from bulk RS

    Science.gov (United States)

    Csáki, Csaba; Randall, Lisa

    2016-07-01

    Recent LHC data hinted at a 750 GeV mass resonance that decays into two photons. A significant feature of this resonance is that its decays to any other Standard Model particles would be too low to be detected so far. Such a state has a compelling explanation in terms of a scalar or a pseudoscalar that is strongly coupled to vector states charged under the Standard Model gauge groups. Such a scenario is readily accommodated in bulk RS with a scalar localized in the bulk away from but close to the Higgs. Turning this around, we argue that a good way to find the elusive bulk RS model might be the search for a resonance with prominent couplings to gauge bosons.

  14. A Diphoton Resonance from Bulk RS

    CERN Document Server

    Csaki, Csaba

    2016-01-01

    Recent LHC data hints at a 750 GeV mass resonance that decays into two photons. A significant feature of this resonance is that its decays to Higges and to any other Standard Model particles are so far too low to be detected. Such a state has a compelling explanation in terms of a scalar or a pseudoscalar that is strongly coupled to vector states charged under the Standard Model gauge groups. We argue that if the state is a scalar, some form of sequestering is likely to be necessary to naturally explain the suppressed scalar-Higgs interactions. Such a scenario is readily accommodated in bulk RS with a scalar localized in the bulk away from the Higgs. Turning this around, we argue that a good way to find the elusive bulk RS model might be the search for a resonance with prominent couplings to gauge bosons.

  15. Lepton flavour violation in the RS model

    Energy Technology Data Exchange (ETDEWEB)

    Moch, Paul; Beneke, Martin [Physik Department T31, Technische Universitaet Muenchen, 85748 Garching (Germany); Rohrwild, Juergen [Rudolf Peierls Centre for Theoretical Physics, University of Oxford, 1 Keble Road, Oxford OX1 3NP (United Kingdom)

    2015-07-01

    We consider charged lepton flavour observables in the Randall-Sundrum (RS) model with and without custodial protection.To this end, we apply a fully five dimensional (5D) framework to calculate the matching coefficients of the effective field theory at the electroweak scale. This enables us to compute predictions for the radiative decay μ → eγ as well as the decay μ → 3e and μ → e conversion in nuclei.

  16. Association of Polymorphisms (rs 1799782, rs25489 and rs25487) in XRCC1 and (rs 13181) XPD genes with Acute Coronary Artery Syndrome in Subjects from Multan, Pakistan.

    Science.gov (United States)

    Hameed, Hafsa; Faryal, Maemona; Aslam, Muhammad Assad; Akbar, Atif; Saad, Abu Bakar Ali; Pasha, Muhammad Burhan; Latif, Muhammad; Rehan Sadiq Shaikh, Rehan Rehan Sadiq Shaikh; Ali, Muhammad; Iqbal, Furhan

    2016-05-01

    Acute coronary artery syndrome (ACS) is the major cause of mortality in Pakistan with genetic and environmental influence on the incidence of the disease. This case-control study was designed to find out if a correlation is existing between ACS and single nucleotide polymorphisms (SNPs) in DNA repair genes XPD [at codon 751, rs 13181 (Lys to Gln)] and XRCC1 [at codon 399, rs25487 (Arg to Gln); 280, rs25489 (Arg to His) and 194, rs 1799782 (Arg to Trp)] either individually or in various combination with each other (haplotype analysis). The objective of this study was to find out the association of various studied risk factors and serum lipid profile of the subjects with the disease, if any. PCR-RFLP method was used to determine genotype at specific codon in 221 subjects (115 ACS patients and 106 healthy controls) from Southern Punjab population. Genotypic and allelic frequency distribution among the cases and controls revealed that all the studied SNPs were not individually associated with the ACS. Haplotype analysis revealed that subjects having wild type combination of all three XRCC1 SNPs had greater susceptibility to ACS than any other studied genotypic combinations. Analysis of risk factors revealed that hypertension (Pdiabetes (P<0.001) were significantly associated with the incidence of ACS. Serum lipid profile analysis indicated that cholesterol level was significantly higher (P=0.048) in patients (161.5mg/dL) than controls (142.1mg/dL) while triglyceride remained unaffected (P=0.87) when compared between the two treatments. PMID:27166553

  17. Complex Bedforms and Complex Water Masses: A Case Study from the Tertiary to Present-day, Pelotas Basin, Offshore Uruguay

    Science.gov (United States)

    Thompson, P.; Badalini, G.; Wrigley, S.; Walker, R.; Argent, J.; Hernandez-Molina, J.; de Santa Ana, H.; Soto, M.; Tomasini, J.

    2015-12-01

    Contour currents are commonly associated with bedform development on modern seabeds yet there is a general paucity of published examples from the ancient record. Recently acquired 3D seismic data, covering over 13000km2 of the Pelotas Basin, offshore Uruguay, provides a unique opportunity to study the architecture and development of a variety of bedform. The data shows that, throughout the Tertiary, contour currents were the dominant control on sedimentation along the Uruguayan margin. The first evidence of contour current activity is during the Early Tertiary in the form of a major regional unconformity that, even though it was fully subaqueous, does not show any major features associated with downslope sedimentation. In the mid-slope region, the unconformity coincides with an extensive (1500km2) intra-slope scour-field orientated parallel to the slope. Individual scours are up to 40m deep, 500m wide and 3km long. Coeval with these scours are a group of coalesced basin floor scours, which run parallel to the base of slope and extend over 400km2. Individual scours exhibit an asymmetric shape - similar to giant flute marks - that are up to 150m deep, 20km wide and extend for at least 40km along slope. The development of these scoured areas shows clear evidence of two major north-flowing water masses. Directly above this regional unconformity are a series of ribbon-like bedforms that developed oblique to the slope. Individual bedforms are up to 40km in length with wavelengths of 5km and heights up to 100m. These bedforms are overlain by a set of barchan-like dunes, up to 30km in length with wavelengths of 10km. Individual dunes are in the order of 100m thick and stack to form an overall package up to 500m thick. These features show a clear change from erosion/bypass to deposition/reworking that is linked to a decrease in ocean current velocity and/ or sediment supply. The features observed suggest a complex oceanic regime was present throughout the Tertiary that

  18. Application of RS Codes in Decoding QR Code

    Institute of Scientific and Technical Information of China (English)

    Zhu Suxia(朱素霞); Ji Zhenzhou; Cao Zhiyan

    2003-01-01

    The QR Code is a 2-dimensional matrix code with high error correction capability. It employs RS codes to generate error correction codewords in encoding and recover errors and damages in decoding. This paper presents several QR Code's virtues, analyzes RS decoding algorithm and gives a software flow chart of decoding the QR Code with RS decoding algorithm.

  19. Trails, RS2477, RS2477, Published in 2008, 1:24000 (1in=2000ft) scale, Box Elder County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2008. It is described as 'RS2477'....

  20. Trails, RS2477, rs2477 add roads, Published in 2006, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2006. It is described as 'rs2477 add...

  1. Novel biosensor-based microarray assay for detecting rs8099917 and rs12979860 genotypes

    Institute of Scientific and Technical Information of China (English)

    Pei-Yuan Li; Xiao-Jun Zhou; Lan Yao; Xin-Hua Fang; Jiang-Nan Ren; Jia-Wu Song

    2012-01-01

    AIM:To evaluate a novel biosensor-based microarray (BBM) assay for detecting rs12979860 and rs8099917genotypes.METHODS:Four probes specific for rs8099917C/T or rs12979860G/T detection and three sets of quality control probes were designed,constructed and arrayed on an optical biosensor to develop a microarray assay.Two sets of primers were used in a one tube polymerase chain reaction (PCR) system to amplify two target fragments simultaneously.The biosensor microarray contained probes that had been sequenced to confirm that they included the rsS099917C/T or rs12979860G/T alleles of interest and could serve as the specific assay standards.In addition to rehybridization of four probes of known sequence,a total of 40 clinical samples collected from hepatitis C seropositive patients were also tested.The target fragments of all 40 samples were amplified in a 50 μL PCR system.Ten μL of each amplicon was tested by BBM assay,and another 40 μL was used for sequencing.The agreement of the results obtained by the two methods was tested statistically using the kappa coefficient.The sensitivity of the BBM assay was evaluated using serial dilutions of ten clinical blood samples containing 103-104 white cells/lμL.RESULTS:As shown by polyacrylamide gel electrophoresis,two target segments of the interleukin 28B-associated polymorphisms (SNPs) were successfully amplified in the one-tube PCR system.The lengths of the two amplified fragments were consistent with the known length of the target sequences,137 and 159bps.After hybridization of the PCR amplicons with the probes located on the BBM array,the signals of each allele of both the rs8099917 SNPs and rs12979860 SNPs were observed simultaneously and were clearly visible by the unaided eye.The signals were distinct from each other,could be interpreted visually,and accurately recorded using an ordinary digital camera.To evaluate the specificity of the assay,both the plasmids and clinical samples were applied to the microarray

  2. Mass and Reliability System (MaRS)

    Science.gov (United States)

    Barnes, Sarah

    2016-01-01

    The Safety and Mission Assurance (S&MA) Directorate is responsible for mitigating risk, providing system safety, and lowering risk for space programs from ground to space. The S&MA is divided into 4 divisions: The Space Exploration Division (NC), the International Space Station Division (NE), the Safety & Test Operations Division (NS), and the Quality and Flight Equipment Division (NT). The interns, myself and Arun Aruljothi, will be working with the Risk & Reliability Analysis Branch under the NC Division's. The mission of this division is to identify, characterize, diminish, and communicate risk by implementing an efficient and effective assurance model. The team utilizes Reliability and Maintainability (R&M) and Probabilistic Risk Assessment (PRA) to ensure decisions concerning risks are informed, vehicles are safe and reliable, and program/project requirements are realistic and realized. This project pertains to the Orion mission, so it is geared toward a long duration Human Space Flight Program(s). For space missions, payload is a critical concept; balancing what hardware can be replaced by components verse by Orbital Replacement Units (ORU) or subassemblies is key. For this effort a database was created that combines mass and reliability data, called Mass and Reliability System or MaRS. The U.S. International Space Station (ISS) components are used as reference parts in the MaRS database. Using ISS components as a platform is beneficial because of the historical context and the environment similarities to a space flight mission. MaRS uses a combination of systems: International Space Station PART for failure data, Vehicle Master Database (VMDB) for ORU & components, Maintenance & Analysis Data Set (MADS) for operation hours and other pertinent data, & Hardware History Retrieval System (HHRS) for unit weights. MaRS is populated using a Visual Basic Application. Once populated, the excel spreadsheet is comprised of information on ISS components including

  3. Vinte e quatro meses de heterocontrole da fluoretação das águas de abastecimento público de Pelotas, Rio Grande do Sul, Brasil Twenty-four months of external control of fluoride levels in the public water supply in Pelotas, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Fábio Garcia Lima

    2004-04-01

    Full Text Available O objetivo deste estudo foi monitorar, mensalmente, os níveis de flúor na água de abastecimento público de Pelotas, Rio Grande do Sul, Brasil, bem como verificar a validade da formação de grupos de heterocontrole. Pelotas foi dividida em 16 pontos geográficos, incluindo as três Estações de Tratamento da água e a coleta foi feita de novembro de 1999 a outubro de 2001, em duplicata. Após a coleta, as amostras foram enviadas ao Laboratório de Vigilância Sanitária de Flúor da Universidade do Vale do Itajaí, onde a análise foi feita utilizando-se o método eletrométrico (Orion 920A/Eletrodo Orion 9609. Após 24 meses, 764 unidades amostrais foram coletadas e verificou-se uma inconstância nos resultados, predominando níveis insuficientes de flúor até o primeiro trimestre de 2001, quando houve um significativo aumento no número de unidades amostrais com uma concentração de flúor ideal (0,6-0,9ppmF, porém, há o surgimento de pontos revelando um excesso de fluoretos (> 1ppmF. Os resultados permitiram concluir que o heterocontrole é fundamental para buscar a manutenção de um correto programa de FAAP.The aim of the present study was monthly evaluation of fluoride levels in the public water supply in Pelotas, Rio Grande do Sul State, Brazil, and the validity of forming external control groups. Pelotas was divided into 16 geographic regions, including the three public water treatment stations. Water samples were collected from November 1999 to October 2001. Two samples were drawn from each region. Samples were sent to the Fluoride Health Surveillance Laboratory at Universidade do Vale do Itajaí. Fluoride analysis used an electrometric method (Orion 920 A/Electrometer Orion 9609. After 24 months, 764 samples were collected, demonstrating a discontinuity in the fluoride levels. There was an increase in the number of samples with an ideal concentration of fluoride. However, several points with excessive fluoride levels (> 0.9ppm

  4. High-Speed RaPToRS

    Science.gov (United States)

    Henchen, Robert; Esham, Benjamin; Becker, William; Pogozelski, Edward; Padalino, Stephen; Sangster, Thomas; Glebov, Vladimir

    2008-11-01

    The High-Speed Rapid Pneumatic Transport of Radioactive Samples (HS-RaPToRS) system, designed to quickly and safely move radioactive materials, was assembled and tested at the Mercury facility of the Naval Research Laboratory (NRL) in Washington D.C. A sample, which is placed inside a four-inch-diameter carrier, is activated before being transported through a PVC tube via airflow. The carrier travels from the reaction chamber to the end station where it pneumatically brakes prior to the gate. A magnetic latch releases the gate when the carrier arrives and comes to rest. The airflow, optical carrier-monitoring devices, and end gate are controlled manually or automatically with LabView software. The installation and testing of the RaPToRS system at NRL was successfully completed with transport times of less than 3 seconds. The speed of the carrier averaged 16 m/s. Prospective facilities for similar systems include the Laboratory for Laser Energetics and the National Ignition Facility.

  5. Intake of fat and fiber-rich foods according to socioeconomic status: the 11-year follow-up of the 1993 Pelotas (Brazil) birth cohort study

    Science.gov (United States)

    Neutzling, Marilda B.; Araújo, Cora Luiza; Vieira, Maria de Fátima A.; Hallal, Pedro C.; Menezes, Ana M. B.; Victora, Cesar G.

    2013-01-01

    This study describes the food intake of adolescents participating in the 1993 birth cohort from Pelotas, Southern Brazil, according to socioeconomic position. We carried out a cross-sectional analysis of data collected in the 2004-2005 follow-up visit. Food intake in the previous year was evaluated using the Block questionnaire. Socioeconomic status was evaluated based on an assets index, divided into quintiles. Foods with the highest frequency of daily intake were white bread (83%), butter or margarine (74.6%), beans (66.4%) and milk (48.5%). Intake of butter or margarine, bread, and beans was more frequent among poorer adolescents, and the inverse was true for milk. Intake of fruits and vegetables was low in all socioeconomic strata, but particularly low among the poor. In early adolescence, all socioeconomic groups showed high consumption of foods rich in fat and low consumption of foods rich in fiber. PMID:20963287

  6. Imagens de humor e de política: relações entre a imprensa ilustrada e a simbologia republicana. Pelotas, 1880-1889

    OpenAIRE

    Aristeu Elisandro Machado Lopes

    2009-01-01

    Nos anos 1880, a propaganda republicana começou em Pelotas com a fundação do clube e do partido republicanos. A partir daí, a propagação das atividades era constantemente noticiada nos órgãos da imprensa local. Entre eles, dois periódicos eram ilustrados e humorísticos: Cabrion (1879-1881) e A Ventarola (1887-1889). Sem descuidar da função primordial do jornal – provocar o riso do leitor através de uma apresentação humorística da realidade – esses periódicos informaram e satirizaram o process...

  7. Design of USB 、RS232/RS422 interface convertion circuit%USB、RS232/S422接口转换电路的设计

    Institute of Scientific and Technical Information of China (English)

    黄燕妮; 王少云

    2012-01-01

    由于USB接口正逐步替代传统的RS232接口成为PC机的标准接口,USB接口转换电路的设计就很有必要。采用Silicon公司高集成度的USB—UART桥接器件CP2102,辅以简单的外部电路,实现了RS232/RS422接口与USB接口转换电路的设计。其中在详细介绍CP2102结构和特性的基础上,给出了接口转换的硬件电路图,最后简单介绍了转换器的工作原理。%Due to USB(Universal Serial Bus) interface is gradually replacing the traditional RS232 interface,and becoming the PC standard interface, the conversion circuit of USB,RS232 / RS422 interface is important and necessary. Using Silicon's CP2102 which is highly-integrated USB to UART bridge device, the paper provides USB interface convertion with a simple external circuit. On the basis of introducting the feature and structure of CP2102, the paper gives how to design hardware circuit of USB ,RS232 / RS422 interface conversion and how to use it.

  8. El desarrollo de la investigación sobre pelota valenciana: guía bibliográfica y fuentes de información

    Directory of Open Access Journals (Sweden)

    Gregorio González Alcaide

    2016-03-01

    Full Text Available Se presenta un estudio bibliográfico de los trabajos académicos sobre Pelota Valenciana, efectuado a partir de la consulta de las fuentes documentales de la Federació de Pilota Valenciana, del Museu de la Pilota de Genovés y de diversos catálogos y bases de datos. Se han identificado 181 trabajos, entre artículos de revistas (n = 95, publicaciones monográficas (n = 40, comunicaciones a congresos (n=37, tesis doctorales (n = 5 y obras de referencia (n = 4. Los trabajos pioneros se remontan a los años 60 y 70 del siglo xx, mientras que se observa una gran eclosión de publicaciones a partir de mediados de la década de los 80, en una tendencia que se mantiene hasta la actualidad, y que coincide con la edición de revistas especializadas, con la celebración de diferentes congresos y reuniones científicas y con la lectura de algunas tesis doctorales. Entre las materias abordadas en los trabajos, encontramos estudios históricos sobre su origen y desarrollo, investigaciones centradas en los espacios físicos en que tiene lugar el juego, en las distintas modalidades, en el vocabulario, que estudian el interés y la importancia que tiene para el ámbito educativo, análisis sociológicos y estudios médicos sobre las enfermedades relacionadas con la práctica de la pelota como actividad deportiva.

  9. 32 CFR 2004.5 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... ARCHIVES AND RECORDS ADMINISTRATION NATIONAL INDUSTRIAL SECURITY PROGRAM DIRECTIVE NO. 1 Implementation and... departments and agencies authorized in EO 12829, as amended, to establish industrial security programs: The... organizational entity delegated by the Head of a CSA to administer industrial security on behalf of the CSA....

  10. Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China

    OpenAIRE

    Gao, Kaiping; Wang, Jinjin; Li, Linlin; Zhai, Yujia; Ren, Yongcheng; You, Haifei; Wang, Bingyuan; Wu, Xuli; Li, Jianna; Liu, Zichen; Li, Xiong; Huang, Yaxin; Luo, Xin-Ping; Hu, Dongsheng; Ohno, Kinji

    2016-01-01

    Genetic variants at KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963 have been associated with type 2 diabetes mellitus (T2DM), but the results are contradictory in Chinese populations. The aim of the present study was to investigate the association of these four SNPs with T2DM in a large population of Han Chinese at Henan province, China. Seven-hundred-thirty-six patients with T2DM (cases) and Seven-hundred-sixty-eight healthy glucose-tolerant controls were genotyped for K...

  11. Association analysis of APOA5 rs662799 and rs3135506 polymorphisms with obesity in Moroccan patients.

    Science.gov (United States)

    Lakbakbi El Yaagoubi, F; Charoute, H; Bakhchane, A; Ajjemami, M; Benrahma, H; Errouagui, A; Kandil, M; Rouba, H; Barakat, A

    2015-12-01

    The aim of the present study is to explore the association between the APOA5 polymorphisms and haplotypes with obesity in Moroccan patients. The study was performed in 459 subjects, Obese (n=164) and non-obese (n=295). All subjects were genotyped for the APOA5 -1131T>C (rs662799) and c.56C>G (rs3135506) polymorphisms. The contribution of APOA5 polymorphisms and haplotypes in the increased risk of obesity were explored using logistic regression analyses. The -1131T>C and c.56C>G polymorphisms were significantly associated with obesity. Both polymorphisms were strongly associated with increased BMI. Analysis of constructed haplotypes showed a significant association between CG haplotype and susceptibility to obesity (OR [95%CI]=3.09 [1.93-4.97]; Pobesity.

  12. The 3Rs principle – mind the ethical gap!

    DEFF Research Database (Denmark)

    Olsson, I. Anna S.; Franco, Nuno H.; Weary, Daniel M.;

    2012-01-01

    Over the 50 years since they were first proposed, the 3Rs (Replacement, Reduction, Refinement) have made a tremendous impact. These principles seem to unify concerns for better science with causing less harm to animals. The ideas behind the 3Rs are so intuitively compelling that it is tempting to...

  13. RS-Predictor models augmented with SMARTCyp reactivities

    DEFF Research Database (Denmark)

    Zaretzki, Jed; Rydberg, Patrik; Bergeron, Charles;

    2012-01-01

    RS-Predictor is a tool for creating pathway-independent, isozyme-specific site of metabolism (SOM) prediction models using any set of known cytochrome P450 substrates and metabolites. Until now, the RS-Predictor method was only trained and validated on CYP 3A4 data, but in the present study we re...

  14. Configuration control plan for the ports NCS IBM RS/6000

    International Nuclear Information System (INIS)

    This document describes the actions and responsibilities for maintaining the quality and integrity of the NS software resident on the IBM RS/6000 workstation managed by the Nuclear Criticality Safety group at the Portsmouth Gaseous Diffusion Plant. This document does not address the validation of NS software packages for the RS/6000

  15. Determinantes e padrões de utilização da bicicleta e acidentes de trânsito sofridos por ciclistas trabalhadores da cidade de Pelotas, Rio Grande do Sul, Brasil Determinants and patterns of bicycle use and traffic accidents among bicycling workers in Pelotas, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Giancarlo Bacchieri

    2005-10-01

    Full Text Available Um estudo transversal de base-populacional foi realizado em Pelotas, sul do Brasil, objetivando pesquisar os determinantes e padrões de utilização da bicicleta como modo de transporte para o trabalho. Foram também descritos os acidentes ocorridos nos últimos 12 meses no deslocamento de ida e volta para o trabalho e a utilização de equipamentos de segurança na bicicleta. A amostra incluiu 1.705 trabalhadores com 15 anos ou mais de idade, residentes na zona urbana, que utilizavam modos de transporte para o trabalho. Análises bruta e ajustada foram realizadas por meio de regressão de Poisson, considerando o efeito do delineamento. A prevalência de utilização da bicicleta foi de 17,2% (IC95%: 15,4-19,0. Trabalhadores homens, com baixa escolaridade e nível econômico mais baixo apresentaram as maiores prevalências. Menos de 1,0% das bicicletas possuía os equipamentos de segurança exigidos pelo Código de Trânsito Brasileiro e 15,0% não tinham freios. Aproximadamente 6,0% desses trabalhadores sofreram acidentes de trânsito com lesões corporais nos últimos 12 meses. Concluímos que trabalhadores que utilizam bicicleta como modo de transporte são prioritários para intervenções preventivas relacionadas a acidentes de trânsito.A population-based cross-sectional study was conducted in Pelotas, southern Brazil, focusing on the determinants and patterns of bicycle use as a mode of commuting by workers. Accidents during commuting and use of safety equipment were also studied. The sample included 1,705 workers (> 15 years of age living in the urban area of Pelotas and using various modes of transportation during commuting. Crude and adjusted analyses were performed using Poisson regression, taking the design effect into account. Prevalence of bicycle use was 17.2% (95%CI: 15.4%-19.0%. Male workers and those with low schooling and low income presented higher prevalence. Less than 1.0% of the bicycles featured the safety equipment

  16. RS485 Image Sensor for Digital Cinema System

    Directory of Open Access Journals (Sweden)

    Eunju Kim

    2016-01-01

    Full Text Available To activate various devices using RS485, a repeater is generally used. In current digital cinema systems, each device is controlled with RS485 by mixing RS485 and DMX512. However, as today’s cinema equips hundreds of 4D chairs and the environmental directors, it is nearly infeasible for the legacy system to control. To this end, this paper designs and implements a new system which makes hundreds of 4D chairs and the environmental directors be controlled simultaneously exploiting RS485 network topology and its repeaters. The proposed approach is tested in a real-time system for assessing the performance by Paessler Router Traffic Grapher (PRTG in Windows environment. Simulation results show that the tested system supports 4D chairs and their motions are well operated simultaneously with RS485.

  17. On the RS2 realization of unparticles

    Energy Technology Data Exchange (ETDEWEB)

    Friedland, Alexander [Theoretical Division, MS B0285, Los Alamos National Laboratory, Los Alamos, NM 87544 (United States)], E-mail: friedland@lanl.gov; Giannotti, Maurizio; Graesser, Michael [Theoretical Division, MS B0285, Los Alamos National Laboratory, Los Alamos, NM 87544 (United States)

    2009-07-06

    We consider the Randall-Sundrum 2 setup with the Standard Model fields on the brane and a massive vector field in the warped bulk. We show that in this model the known properties of vector unparticles - the nontrivial phase of the CFT propagator, the necessity and dominance of contact interactions, the unitarity constraint on the conformal dimension of the operator, and the tensor structure dictated by conformal symmetry - follow by simple inspection of the brane-to-brane propagator. The phase has a physical interpretation as controlling the rate of escape of unparticles into the extra dimension. Requiring the correct sign for the imaginary part of the longitudinal polarization of the propagator, we obtain the unitarity condition m{sub 5}{sup 2}{>=}0, which, unlike in the scalar case, is unchanged from flat space. This condition results in the unitarity bound d{sub V}{>=}3, or, more generally, d{sub V}{>=}D-1 for a vector unparticle in D-dimensional space. It is instructive to consider the RS2 propagator in (Euclidean) position space: at large distances it behaves as a pure CFT propagator, while at short distances it turns into the softer 5d flat space propagator. In contrast, in momentum space, at low momenta the CFT piece is subdominant to the 'contact' interactions.

  18. Association between MYO9B rs962917 and rs1545620 gene polymorphism and clinical characteristic of inflammatory bowel disease

    Institute of Scientific and Technical Information of China (English)

    黄健

    2014-01-01

    Objective To investigate the association between MYO9B rs962917 and rs1545620 gene polymorphism and clinical pathological characteristics of patients with inflammatory bowel disease(IBD)and permeability of intestinal mucosa.Methods From September 2010 to May2012,a total of 196 cases of patients with IBD were collected,

  19. Leukocyte telomere length-related rs621559 and rs398652 genetic variants influence risk of HBV-related hepatocellular carcinoma.

    Science.gov (United States)

    Pan, Wenting; Cheng, Guangxia; Xing, Huaixin; Shi, Juan; Lu, Chao; Wei, Jinyu; Li, Lichao; Zhou, Changchun; Yuan, Qipeng; Zhou, Liqing; Yang, Ming

    2014-01-01

    Recent genome-wide association studies (GWAS) have identified eleven leukocyte telomere length (LTL)-related single nucleotide polymorphisms (SNPs). Since LTL has been associated with risk of many malignancies, LTL-related SNPs may contribute to cancer susceptibility. To test this hypothesis in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), we genotyped these eleven LTL-related SNPs in a case-control set including 1186 HBV-related HCC cases, 508 chronic HBV carriers and 1308 healthy controls at the discovery stage. The associations of HCC risk with these SNPs were further confirmed in an independent case-control set. We found that 1p34.2 rs621559 and 14q21 rs398652 were significantly associated with HBV-related HCC risk (both PHCC cases and 1954 controls), we observed a decreased HCC risk, 0.72-times, associated with the 1p34.2 rs621559 AA genotype compared to the GG genotype (P = 1.6×10(-6)). Additionally, there was an increased HCC risk, 1.27-fold, associated with the rs398652 GG genotype (P = 3.3×10(-6)). A statistical joint effect between the rs621559 GG and rs398652 GG genotypes may exist in elevating risk of HBV-related HCC. We show, for the first time, that rs398652 and rs621559 might be marker genetic variants for risk of HBV-related HCC in the Chinese population. PMID:25365256

  20. Abundância e flutuação populacional das espécies de Chrysomya (Diptera, Calliphoridae em Pelotas, Rio Grande do Sul, Brasil Abundance and populational fluctuation of Chrysomya (Diptera, Calliphoridae species, in Pelotas, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Élvia E. S. Vianna

    2004-09-01

    Full Text Available To estimate the populational fluctuation of Chrysomya Robineau-Desvoidy, 1830 species and the relation of populational abundance around, six wind oriented trap (WOT were placed in three distinct ecological areas (urban, rural and wild in Pelotas, Rio Grande do Sul, Brazil, from February/1993 to January/1995. The flies were weekly collected. Captured species were Chrysomya albiceps Wiedmann, 1819, C. megacephala Fabricius, 1794 and C. putoria Wiedmann, 1830 with respective abundance of 64.5%, 19.7% and 0.9%, representing a total of 85.0% of 409,920 specimens of Calliphoridae. The three species demonstrated similarity in the populational fluctuation, except in the abundance. The populational peak ocurred in autum when the temperature decreases. In the months of July to November no fly was collected, recomposing the population in December, when the temperature surpassed 20ºC.

  1. Leukocyte telomere length-related rs621559 and rs398652 genetic variants influence risk of HBV-related hepatocellular carcinoma.

    Directory of Open Access Journals (Sweden)

    Wenting Pan

    Full Text Available Recent genome-wide association studies (GWAS have identified eleven leukocyte telomere length (LTL-related single nucleotide polymorphisms (SNPs. Since LTL has been associated with risk of many malignancies, LTL-related SNPs may contribute to cancer susceptibility. To test this hypothesis in hepatitis B virus (HBV-related hepatocellular carcinoma (HCC, we genotyped these eleven LTL-related SNPs in a case-control set including 1186 HBV-related HCC cases, 508 chronic HBV carriers and 1308 healthy controls at the discovery stage. The associations of HCC risk with these SNPs were further confirmed in an independent case-control set. We found that 1p34.2 rs621559 and 14q21 rs398652 were significantly associated with HBV-related HCC risk (both P<0.005 after Bonferroni corrections. There was no significant difference of either rs621559 or rs398652 genotypes between chronic HBV carriers and healthy controls, demonstrating that the association was not due to predisposition to HBV infection. In the pooled analyses (1806 HBV-related HCC cases and 1954 controls, we observed a decreased HCC risk, 0.72-times, associated with the 1p34.2 rs621559 AA genotype compared to the GG genotype (P = 1.6×10(-6. Additionally, there was an increased HCC risk, 1.27-fold, associated with the rs398652 GG genotype (P = 3.3×10(-6. A statistical joint effect between the rs621559 GG and rs398652 GG genotypes may exist in elevating risk of HBV-related HCC. We show, for the first time, that rs398652 and rs621559 might be marker genetic variants for risk of HBV-related HCC in the Chinese population.

  2. Concurrent determinants of blood pressure among adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil) birth cohort study

    Science.gov (United States)

    Menezes, Ana M. B.; Hallal, Pedro C.; Araújo, Cora Luiza; Barros, Fernando C.; Victora, Cesar G.

    2013-01-01

    The aim of this study was to evaluate concurrent risk factors for high blood pressure in adolescents. This is a prospective cohort study including 4,452 adolescents born in Pelotas, Rio Grande do Sul State, Brazil, in 1993. Blood pressure was measured before and after the interview, and the mean value was used in the analyses. Mean systolic blood pressure was 101.9mmHg (SD = 12.3) and mean diastolic pressure was 63.4mmHg (SD = 9.9). Adolescents with black skin had higher blood pressure than those with white skin. Mean systolic pressure among subjects in the top quartile of body mass index (BMI) was 11.6mmHg higher than among those in the lowest quartile. Mean systolic pressure among postmenarcheal girls was 5.4mmHg higher than among premenarcheal girls. Similar trends were found for diastolic arterial pressure. Our findings suggest that blood pressure control must begin already in childhood and adolescence. PMID:20963295

  3. Inhaler use in adolescents and adults with self-reported physician-diagnosed asthma, bronchitis, or emphysema in the city of Pelotas, Brazil

    Directory of Open Access Journals (Sweden)

    Paula Duarte de Oliveira

    2013-06-01

    Full Text Available OBJECTIVE: To evaluate the characteristics of users of inhalers and the prevalence of inhaler use among adolescents and adults with self-reported physician-diagnosed asthma, bronchitis, or emphysema. METHODS: A population-based study conducted in the city of Pelotas, Brazil, involving 3,670 subjects ≥ 10 years of age, evaluated with a questionnaire. RESULTS: Approximately 10% of the sample reported at least one of the respiratory diseases studied. Among those individuals, 59% reported respiratory symptoms in the last year, and, of those, only half reported using inhalers. The use of inhalers differed significantly by socioeconomic status (39% and 61% for the lowest and the highest, respectively, p = 0.01. The frequency of inhaler use did not differ by gender or age. Among the individuals reporting emphysema and inhaler use, the use of the bronchodilator-corticosteroid combination was more common than was that of a bronchodilator alone. Only among the individuals reporting physician-diagnosed asthma and current symptoms was the proportion of inhaler users higher than 50%. CONCLUSIONS: In our sample, inhalers were underutilized, and the type of medication used by the individuals who reported emphysema does not seem to be in accordance with the consensus recommendations.

  4. A survey of oral and maxillofacial biopsies in children: a single-center retrospective study of 20 years in Pelotas-Brazil

    Directory of Open Access Journals (Sweden)

    Giana da Silveira Lima

    2008-12-01

    Full Text Available Despite the large number of published cases about oral and maxillofacial pediatric lesions, the literature is scarce on epidemiological studies regarding the prevalence of these entities. This study retrieved oral and maxillofacial pediatric lesions from the Center of Diagnosis of Oral Diseases (CDDB at the Dental School of the Federal University of Pelotas (UFPEL, comprising a 20-year period (1983-2002. From the total of 9,465 biopsies received in this period, 625 (6.6% were from children aged 0 to 14 years. Regardless of the histopathological diagnosis, patient data referring to lesion location, sex and age were collected. Diagnoses were grouped in 13 categories. As much as 89% of the cases occurred in patients aged 7 to 14 years (53% in females and 47% in males. Mucocele (17.2% was the most common type of lesion, followed by dentigerous cyst (8.6%. In the category of odontogenic tumors, odontoma was the most frequent lesion (64.2%. Malignant lesions were observed in a small section of the sample (1.2%. Generally, the results of the present study are in line with those reported in the literature concerning the most prevalent lesions in the pediatric population. Most lesions were benign, and malignant lesions were diagnosed in a very small part of the sample.

  5. Imagens de humor e de política: relações entre a imprensa ilustrada e a simbologia republicana. Pelotas, 1880-1889

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    Aristeu Elisandro Machado Lopes

    2009-04-01

    Full Text Available Nos anos 1880, a propaganda republicana começou em Pelotas com a fundação do clube e do partido republicanos. A partir daí, a propagação das atividades era constantemente noticiada nos órgãos da imprensa local. Entre eles, dois periódicos eram ilustrados e humorísticos: Cabrion (1879-1881 e A Ventarola (1887-1889. Sem descuidar da função primordial do jornal – provocar o riso do leitor através de uma apresentação humorística da realidade – esses periódicos informaram e satirizaram o processo republicano. Este artigo busca analisar a vinculação entre esses periódicos e a questão republicana durante as atividades de propaganda e, especificamente, como ocorreu o emprego da simbologia republicana na elaboração das ilustrações.

  6. Distúrbios menstruais entre mulheres de 15-54 anos de idade em Pelotas, Rio Grande do Sul, Brasil: estudo de base populacional

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    Raquel Siqueira Barcelos

    2013-11-01

    Full Text Available Para avaliar a prevalência de distúrbios menstruais e sua distribuição conforme paridade e características demográficas, sociais e comportamentais, entre 15-54 anos de idade, realizou-se estudo transversal de base populacional, em Pelotas, Rio Grande do Sul, Brasil, com 1.078 mulheres. Foram investigados sangramento menstrual excessivo, sangramento intermenstrual, ciclo menstrual curto, ciclo menstrual longo e menstruação prolongada. Foram calculadas as taxas de prevalência, com intervalos de 95% de confiança. A prevalência global de distúrbios menstruais foi 46,4% (43,4-49,4. O mais prevalente foi sangramento menstrual excessivo (23,2%; 20,5-25,8, seguido de ciclo menstrual curto (19,2%; 16,6-21,8, ciclo menstrual longo (14,8%; 12,7-16,9, sangramento intermenstrual (11,1%; 9,1-13,2 e menstruação prolongada (7,9%; 6,3-9,4. Os distúrbios menstruais são frequentes na população, estando associados à idade maior que 34 anos, escolaridade menor que cinco anos, maior paridade, laqueadura tubária e tabagismo.

  7. Interleukin-10 rs2227307 and CXCR2 rs1126579 polymorphisms modulate the predisposition to septic shock

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    Cristina Padre Cardoso

    2015-06-01

    Full Text Available Despite major improvements in its treatment and diagnosis, sepsis is still a leading cause of death and admittance to the intensive care unit (ICU. Failure to identify patients at high risk of developing septic shock contributes to an increase in the sepsis burden and rapid molecular tests are currently the most promising avenue to aid in patient risk determination and therapeutic anticipation. The primary goal of this study was to evaluate the genetic susceptibility that affects sepsis outcome in 72 sepsis patients admitted to the ICU. Seven polymorphisms were genotyped in key inflammatory response genes in sepsis, including tumour necrosis factor-α, interlelukin (IL-1β, IL-10, IL-8, Toll-like receptor 4, CXCR1 and CXCR2. The primary finding showed that patients who were homozygous for the major A allele in IL-10 rs1800896 had almost five times higher chance to develop septic shock compared to heterozygotes. Similarly, selected clinical features and CXCR2 rs1126579 single nucleotide polymorphisms modulated septic shock susceptibility without affecting survival. These data support the hypothesis that molecular testing has clinical usefulness to improve sepsis prognostic models. Therefore, enrichment of the ICU portfolio by including these biomarkers will aid in the early identification of sepsis patients who may develop septic shock.

  8. Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population.

    Directory of Open Access Journals (Sweden)

    James Cheng-Chung Wei

    Full Text Available Ankylosing spondylitis (AS is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. However, the development of anklosing spondylitis is unclear. Human leukocyte antigens HLA-B27 and ERAP1 have been widely reported to be associated with AS susceptibility. A recent genome-wide association study (GWAS showed that two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569 and within ANO6 at 12q12 (rs17095830 contribute to the risk of AS in Han Chinese. In this study, we enrolled 475 AS patients and 475 healthy subjects to assess whether these genetic variations contribute to the susceptibility and the severity of AS in the Taiwanese population. The correlation between genetic polymorphisms, AS activity indexes, (namely, BASDAI, BASFI and BAS-G and AS complications (uveitis and inflammatory bowel disease were tested using the markers, rs4552569 and rs17095830. Although no association between rs4552569/rs17095830 genetic polymorphisms and AS susceptibility/severity was found, a significant association between rs17095830 and inflammatory bowel disease was observed in a Taiwanese population.

  9. Trails, RS2477, picpts, Published in 2006, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2006. It is described as 'picpts'. Data by this publisher are often provided...

  10. IZOBRAŽEVANJE SVETOVALCEV ZAPOSLITVE NA ZAVODU RS ZA ZAPOSLOVANJE

    OpenAIRE

    Kozamernik, Neva

    2010-01-01

    Diplomsko delo obravnava vlogo in pomen izobraževanja svetovalcev zaposlitve na Zavodu RS za zaposlovanje na Območni enoti Ljubljana v povezavi s svetovanjem in pomočjo brezposelnim osebam. Kajti spremembe zunanjega okolja

  11. Trails, RS2477, centerlines83, Published in 2008, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2008. It is described as 'centerlines83'. Data by this publisher are often...

  12. Trails, RS2477, 34b, Published in 2006, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2006. It is described as '34b'. Data by this publisher are often provided in...

  13. Trails, RS2477, wintqutrs, Published in 2008, Carbon County GIS.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Field Survey/GPS information as of 2008. It is described as 'wintqutrs'. Data by this publisher are...

  14. Relationship Between Chronic Tinnitus and Glial Cell Line-Derived Neurotrophic Factor Gene rs3812047, rs1110149, and rs884344 Polymorphisms in a Turkish Population.

    Science.gov (United States)

    Orenay-Boyacioglu, Seda; Coskunoglu, Aysun; Caki, Zerrin; Cam, Fethi Sirri

    2016-08-01

    Glial cell line-derived neurotrophic factor (GDNF) plays a key role in early development of central auditory pathway and the inner ear. However, the auditory pathway studies of GDNF gene polymorphisms are scarce in the literature, and the studies especially associated with tinnitus are limited. Our study aimed to identify whether GDNF gene polymorphisms play any roles in the pathophysiology of tinnitus by investigating the relationship between tinnitus and GDNF polymorphisms. A total of 52 patients with chronic tinnitus and ages ranging from 18 to 55 were admitted to the Ear-Nose-Throat outpatient clinic of Celal Bayar University Medical Faculty Hospital of Manisa, Turkey and constituted the study group. Another 42 patients of the same age range, without tinnitus symptoms and lacking any systemic disease, were also admitted to the clinic and formed the control group. The tympanometric, audiological, and psychoacoustic assessments of the subjects were performed. Deoxyribonucleic acid samples obtained using venous blood taken for routine inspections were used to investigate GDNF gene polymorphisms (rs884344, rs3812047, and rs1110149) by polymerase chain reaction-based restriction fragment length polymorphism method. No correlation could be detected between GDNF rs884344 and rs3812047 polymorphisms and subjects with tinnitus (p > 0.05). Heterozygosity was significantly lower for GDNF rs1110149 polymorphism in tinnitus subjects compared to the controls (p tinnitus and control groups (p > 0.05). Failure to detect correlations between tinnitus and GDNF gene polymorphisms suggests this may be due to the fact that the GDNF gene has a variable expression pattern in different tissues and pathologies. Therefore, the study should be improved and its scope should be expanded by including a larger group of patients and different tissues to investigate the expression pattern of GDNF. PMID:27180191

  15. Have the 3Rs and alternatives been effectively explored?

    Institute of Scientific and Technical Information of China (English)

    Adrian Smith

    2015-01-01

    Although the concept of the 3Rs was developed in the 1950s, it took many years before it became a central theme when planning and conducting experiments which might involve animals.There are still many ways in which protocols can be im-proved to increase both animal welfare and the reliability of the scientific data obtained from the studies. This paper gives some practical advice on how the 3Rs can be implemented more thoroughly in animal research.

  16. Improving Reliability of Communication in RS-485 Design

    Institute of Scientific and Technical Information of China (English)

    蒋小平; 刘晓辉

    2002-01-01

    Three aspects of RS-485 application, which affect the reliability of communication of data system are analyzed and discussed. In network configuration, it presents the optimal configuration for the bus of RS-485, the better rule for derivative line and the choice for termination. In hardware design, it presents three parts of driver's peripheral circuit. In control software design, it presents a method of using 75176's DE line to control the driver.

  17. Association of rs1568885, rs1813443 and rs4411591 polymorphisms with anti-TNF medication response in Greek patients with Crohn’s disease

    Science.gov (United States)

    Thomas, Diamantis; Gazouli, Maria; Karantanos, Theodoros; Rigoglou, Stella; Karamanolis, Georgios; Bramis, Konstantinos; Zografos, George; Theodoropoulos, George E

    2014-01-01

    AIM: To investigate the correlation between rs1568885, rs1813443 and rs4411591 polymorphisms and response to infliximab in a cohort of Greek patients with Crohn’s disease (CD). METHODS: One hundred and twenty-six patients diagnosed with CD based on standard clinical, endoscopic, radiological, and pathological criteria were enrolled in this study at the Gastroenterology Unit of the 2nd Department of Surgery and at the Colorectal Unit of the 1st Department of Propaedeutic Surgery. Infliximab at a dose of 5 mg/kg was administered intravenously at weeks 0, 2, 6 and then every 8 wk. Clinical and serological responses were assessed using the Harvey-Bradshaw Index and serum C-reactive protein (CRP) levels, respectively, and the endoscopic response was evaluated by ileocolonoscopy performed at baseline and after 12-20 wk of therapy. The changes in endoscopic appearance compared to baseline were classified into four categories, and patients were classified as responders and non-responders. Genomic DNA from whole peripheral blood was extracted and genotyping was performed by allele-specific polymerase chain reactions. χ2 test with Yate’s correction based on the S-Plus was used to compare the genotype frequencies. RESULTS: Eighty patients (63.49%) were classified as complete and 32 (25.39%) as partial responders to infliximab, while 14 (11.11%) were primary non-responders. No correlation was found between response to infliximab and patients’ characteristics such as age, gender and disease duration. There was consistency between Harvey-Bradshaw index scores and serum CRP levels. The TT genotype of the rs1568885 polymorphism was significantly related to partial response (P = 0.024) and resistance to infliximab (P = 0.007) while the AT genotype was more frequent in partial responders (P = 0.035) and in primary non-responders (P = 0.032). Regarding rs1813443, the CC genotype was found to be associated with partial response (P = 0.005) and primary resistance (P = 0.002) to

  18. The optimal algorithm for Multi-source RS image fusion.

    Science.gov (United States)

    Fu, Wei; Huang, Shui-Guang; Li, Zeng-Shun; Shen, Hao; Li, Jun-Shuai; Wang, Peng-Yuan

    2016-01-01

    In order to solve the issue which the fusion rules cannot be self-adaptively adjusted by using available fusion methods according to the subsequent processing requirements of Remote Sensing (RS) image, this paper puts forward GSDA (genetic-iterative self-organizing data analysis algorithm) by integrating the merit of genetic arithmetic together with the advantage of iterative self-organizing data analysis algorithm for multi-source RS image fusion. The proposed algorithm considers the wavelet transform of the translation invariance as the model operator, also regards the contrast pyramid conversion as the observed operator. The algorithm then designs the objective function by taking use of the weighted sum of evaluation indices, and optimizes the objective function by employing GSDA so as to get a higher resolution of RS image. As discussed above, the bullet points of the text are summarized as follows.•The contribution proposes the iterative self-organizing data analysis algorithm for multi-source RS image fusion.•This article presents GSDA algorithm for the self-adaptively adjustment of the fusion rules.•This text comes up with the model operator and the observed operator as the fusion scheme of RS image based on GSDA. The proposed algorithm opens up a novel algorithmic pathway for multi-source RS image fusion by means of GSDA.

  19. The optimal algorithm for Multi-source RS image fusion.

    Science.gov (United States)

    Fu, Wei; Huang, Shui-Guang; Li, Zeng-Shun; Shen, Hao; Li, Jun-Shuai; Wang, Peng-Yuan

    2016-01-01

    In order to solve the issue which the fusion rules cannot be self-adaptively adjusted by using available fusion methods according to the subsequent processing requirements of Remote Sensing (RS) image, this paper puts forward GSDA (genetic-iterative self-organizing data analysis algorithm) by integrating the merit of genetic arithmetic together with the advantage of iterative self-organizing data analysis algorithm for multi-source RS image fusion. The proposed algorithm considers the wavelet transform of the translation invariance as the model operator, also regards the contrast pyramid conversion as the observed operator. The algorithm then designs the objective function by taking use of the weighted sum of evaluation indices, and optimizes the objective function by employing GSDA so as to get a higher resolution of RS image. As discussed above, the bullet points of the text are summarized as follows.•The contribution proposes the iterative self-organizing data analysis algorithm for multi-source RS image fusion.•This article presents GSDA algorithm for the self-adaptively adjustment of the fusion rules.•This text comes up with the model operator and the observed operator as the fusion scheme of RS image based on GSDA. The proposed algorithm opens up a novel algorithmic pathway for multi-source RS image fusion by means of GSDA. PMID:27408827

  20. A PERCEPÇÃO DOS INTEGRANTES DOS PROGRAMAS AMBIENTAIS QUE TRABALHAM NA GESTÃO AMBIENTAL DA DUPLICAÇÃO DA BR-116/RS SOBRE O PROGRAMA DE COMUNICAÇÃO SOCIAL

    Directory of Open Access Journals (Sweden)

    Manoela Nogueira Soares

    2013-12-01

    Full Text Available Este trabalho tem o objetivo de conhecer a percepção dos integrantes dos Programas Ambientais, desenvolvidos pela Gestão Ambiental, durante as obras de duplicação da BR-116/RS entre os municípios de Guaíba e Pelotas, somando 211 quilômetros de extensão. A referência para a realização das atividades do Programa de Comunicação está baseada no planejamento estratégico do mesmo, desenvolvido a partir das especificações do Estudo de Impacto Ambiental (EIA, que define as áreas de influência direta e indireta do empreendimento e os objetivos das atividades com as comunidades lindeiras às obras e usuários da rodovia. Neste trabalho são utilizados referenciais teóricos que embasam as ações de comunicação desenvolvidas, destacando a relação entre a comunicação e os demais Programas Ambientais previstos para serem executados durante as obras de duplicação da rodovia. A pesquisa bibliográfica e documental se embasa, principalmente, nos pressupostos de Bordenave (1997. A pesquisa de campo é de natureza exploratória, quantitativa e por acessibilidade do pesquisador.

  1. La tradición lúdica en el currículum educativo. Los juegos y deportes de pelota en Educación Física: una propuesta comprensiva

    Directory of Open Access Journals (Sweden)

    Oidui Usabiaga Arruabarrena

    2012-03-01

    Full Text Available Los juegos han estado basados tradicionalmente en el pacto previo de las condiciones del desafío entre dos bandos. Mediante el pacto, se equilibraban las posibilidades de los contendientes de conseguir la victoria, pues se analizaban las características de los jugadores y sus habilidades y se introducían modificaciones. Esto ha ocurrido de la misma forma en los juegos directos de pelota, que son los que nos ocupan, todavía vivos en algunas zonas del estado como el País Vasco, Navarra o el País Valenciano. Este conocimiento de dichos juegos proviene de una investigación de índole etnográfica desarrollada en el 2007 con el objetivo de rescatar, catalogar y describir los juegos directos de pelota vascos y valencianos. A partir de este trabajo, proponemos el diseño de una progresión didáctica para la introducción de estas actividades en las sesiones de educación física de secundaria. Y lo hacemos desde una perspectiva comprensiva, en la cual el alumnado tiene gran protagonismo no solo en la práctica, sino en el diseño de los desafíos. De este modo, se trata de que el alumnado identifique las modificaciones del juego y los efectos que ellas producen para, con ello, proponer desafíos a otros equipos. Dicha práctica, además, será evaluada por todas las partes. En definitiva, se trata de poner sobre la mesa una propuesta moderna basada en antiguos juegos de pelota.

  2. Eudragit RS PO nanoparticles for sustained release of pyridostigmine bromide

    International Nuclear Information System (INIS)

    Pyridostigmine bromide (PB) is an inhibitor of cholinesterase, which is used in the treatment of myasthenia gravis and administered for protection against exposure to toxic nerve agents. Tests were done to investigate prolonging the half-life of PB and improving its release behavior. PB was loaded in nanoparticles (NPs) of Eudragit RS PO (Eu-RS) prepared using the technique of quasi emulsion solvent diffusion. Variables of output power of the sonicator, bath temperature and mixing time, were chosen as the optimization factors to obtain the minimum sized NPs. In addition, emulsions were tested at different ratios of drug-to-polymer by dynamic light scattering to determine size and zeta potential of NPs. UV-spectroscopy was used to determine PB content of the NPs. Drug-loaded NPs were characterized by scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectra. Results determined that mixing time had a significant impact on the size of Eu-RS NPs, but power output of sonicator and bath temperature had no significant effect. The particle size obtained at the optimum condition (power output of 70 W, bath temperature of 33 °C, and mixing time of 7 min) was less than 200 nm (optimum sizes were 138.9 and 179.5 nm for Eu-RS and PB-loaded Eu-RS NPs, respectively). The optimum PB-loaded Eu-RS NPs at the PB to Eu-RS weight ratio of 1–4 and 20 % of loaded PB released from the nanocarriers within 100 h

  3. The Tutorial Education Program on the Formation of the New Milenium's Meteorologist: 20 Years of Project Experience at Universidade Federal de Pelotas - Brazil

    Science.gov (United States)

    Foster, P.

    2012-12-01

    The Programa de Educação Tutorial (Tutorial Education Program), also known as "PET", has the objective to finance students with potential, encouraging and providing extracurricular activities in order to promote the integration with the academic market and the development of study programs in graduate school, preparing a professional that in the future will operate in a global market, transforming and fighting for the professional interests of their class. The design of the program dates back to 1970 and is based on the model of learning and guidance to form the student. The groups are composed gradually, through an annual selection. The deployment and implementation of the groups consider the inclusion of new members in different stages of their school program, working in an integrated manner. To apply, students must submit satisfactory academic performance, without failures on any course and commit to devote a minimum of twenty hours per week to the program activities. Deployed at Universidade Federal de Pelotas - Brazil, in 1991, the group has contributed to the training of students of Meteorology through the concept of teaching-research-extension activities. We believe that PET has been of utmost importance in the training of the new millennium's professional, given that the objectives of this program seek to provide an excellent level of academic training to undergraduates, encouraging their entry into the graduate studies; stimulating the improvement of the quality of teaching degree through the development of new practices and teaching experience; multiplying the activities developed by scholars and increase their interactions with program's faculty and other students of the institution. With the highly competitive market requiring specialized professionals, the high investment in students with potential can be reversed for the benefit of the profession.

  4. Distribution of Glycated Haemoglobin According to Early-Life and Contemporary Characteristics in Adolescents and Adults without Diabetes: The 1982 and 1993 Pelotas Birth Cohorts

    Science.gov (United States)

    Restrepo-Méndez, María Clara; Silveira, Vera M.; Miranda, Jaime J.; Gonçalves, Helen D.; Oliveira, Isabel O.; Horta, Bernardo L.; Gigante, Denise P.; Menezes, Ana Maria; Assunção, Maria Cecília F.

    2016-01-01

    Aim Glycated haemoglobin (HbA1c), a marker of glucose control in individuals with diabetes mellitus, is also related with the incidence of cardiometabolic risk in populations free of disease. The aim of this study was to describe the distribution of HbA1c levels according to early-life and contemporary factors in adolescents and adults without diabetes mellitus. Methods HbA1c was measured in adults aged 30 years and adolescents aged 18 years who are participants in the 1982 and 1993 Pelotas Birth Cohorts, respectively. Bivariate and multivariate analyses were performed to describe the HbA1c mean values according to early-life and contemporary characteristics collected prospectively since birth. Results The distribution of the HbA1c was approximately normal in both cohorts, with a mean (SD) 5.10% (0.43) in the 1982 cohort, and 4.89% (0.50) in the 1993 cohort. HbA1c mean levels were significantly higher in individuals self-reported as black/brown skin color compared to those self-reported as white in both cohorts. Parental history of diabetes was associated with higher HbA1c mean in adults, while stunting at one year old presented an inverse relation with the outcome in adolescents. No other early and contemporary factors were associated with HbA1c levels in adults or adolescents. Conclusions We found a consistent relationship between HbA1c and skin color in both cohorts. Further research is needed to understand the role of genomic ancestry on levels of HbA1c concentrations which may inform policies and preventive actions for diabetes mellitus and cardiometabolic risk. PMID:27626274

  5. Oral health studies in the 1982 Pelotas (Brazil birth cohort: methodology and principal results at 15 and 24 years of age Estudo longitudinal de saúde bucal na coorte de nascidos vivos em Pelotas, Rio Grande do Sul, Brasil, 1982: aspectos metodológicos e resultados principais aos 15 e 24 anos de idade

    Directory of Open Access Journals (Sweden)

    Karen Glazer Peres

    2011-08-01

    Full Text Available The aim of this study was to describe the methodology and results of oral health studies nested in a birth cohort in Pelotas, Southern Brazil. For the oral health studies a sub-sample (n = 900 was selected from the cohort and dental examinations and interviews were performed at ages 15 (n = 888 and 24 years (n = 720; 81.1%. Data collection included dental outcomes, dental care, oral health behaviors, and use of dental services. Mean DMF-T varied from 5.1 (SD = 3.8 to 5.6 (SD = 4.1 in the study period. The proportion of individuals with at least one filled tooth increased from 51.9% to more than 70%. Individuals who had always been poor used dental services less and had fewer healthy teeth on average than those who had never been poor. Individuals with decreasing or increasing family income trajectories showed intermediate values. An increase was seen in the number of healthy teeth from age 15 to 24 only among those who had never been poor. A history of at least one experience with poverty had a negative impact on oral health in adulthood.Descreveu-se a metodologia e os resultados dos estudos de saúde bucal em uma coorte de nascimentos. Em 1997, uma amostra da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, (n = 900 foi sorteada para o estudo de saúde bucal (15 anos e os mesmos indivíduos foram novamente investigados aos 24 anos. Agravos bucais, cuidados com a saúde bucal e uso de serviços odontológicos foram avaliados. Participaram do estudo 888 adolescentes aos 15 anos e 720 (81,1% aos 24. O índice CPO-D médio variou de 5,1 (DP = 3,8 a 5,6 (DP = 4,1 no período. Ter pelo menos um dente restaurado passou de 51,9% aos 15 anos para mais de 70% aos 24. A proporção do uso de serviços e a média de dentes saudáveis foram menores dentre os sempre pobres quando comparados àqueles nunca pobres. Indivíduos com trajetórias econômicas descendente ou ascendente tiveram valores intermediários. Aumento de dentes saudáveis dos 15

  6. Avaliação do processo da atenção médica: adequação do tratamento de pacientes com diabetes mellitus, Pelotas, Rio Grande do Sul, Brasil Clinical management of diabetic patients: process evaluation in Pelotas, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Maria Cecília Formoso Assunção

    2002-02-01

    Full Text Available Com objetivo de avaliar a adequação do manejo de pacientes diabéticos, durante o ano de 1998 foram entrevistados, em domicílio, pacientes atendidos nos postos de saúde da zona urbana de Pelotas, Rio Grande do Sul, Brasil. Coletaram-se informações relativas a características da doença e do tratamento dos mesmos. Analisou-se o tratamento do diabetes mellitus em três componentes: realização de dieta, atividade física e tratamento medicamentoso. Verificou-se que 76% dos entrevistados receberam orientações dietéticas; porém, apenas metade desses as seguiram nos últimos quinze dias. Dos 75% dos pacientes que receberam orientações sobre exercícios físicos, apenas um terço praticou algum tipo de atividade no último mês. Dos 377 entrevistados, 289 (77% utilizavam algum tipo de medicamento. Grande parte dos usuários de hipoglicemiantes orais apresentavam alguma contra-indicação ao seu uso. Discutiu-se a necessidade de qualificar a aderência dos profissionais de saúde às recomendações de manejo do diabetes.A study was conducted in 1998 with the aim of assessing adequacy of clinical management of diabetic patients attending public health services in Pelotas, Brazil. Patients were interviewed to gather data on medical consultation, disease, and treatment. Data analysis focused on the "type of treatment" variable with three categories: diet, physical activity, and drug treatment. Seventy-six percent of the patients reported having received nutritional orientation. Only 50% of them reported having followed their diet during the preceding 15 days. Also, 75% of patients reported having received recommendations to perform physical activity. However, only one third had practiced some exercise in the previous month. Among 377 interviewed, 289 (77% were on medication, and among the patients taking oral hypoglycemic agents many had at least one contraindication. The article discusses the need to enhance physicians' adherence to

  7. Self-reporting versus parental reporting of physical activity in adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Auto-relato de atividade física na adolescência comparado ao relato dos pais: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Directory of Open Access Journals (Sweden)

    Felipe F. Reichert

    2010-10-01

    Full Text Available The aim of this study was to verify the agreement between different approaches for estimating levels of physical activity in adolescents. One questionnaire was administered to parents and two were administered to the adolescents. This was a cross-sectional analysis of data collected in the 2004-2005 follow-up of the 1993 Pelotas (Brazil birth cohort study. Parents or guardians answered the following question: "Compared to most children the same age, would you say that your child exercises more, less, or the same amount?" A similar question was addressed to adolescents, as was a detailed questionnaire on physical activity. Agreement between the questionnaires was measured by the weighted kappa statistic. A total of 4,254 adolescents and parents/guardians answered the questionnaires. Kappa values indicated low agreement for all comparisons (kappa O objetivo deste estudo foi verificar a concordância entre diferentes formas de se estimar o nível de atividade física de adolescentes. Um questionário foi aplicado aos pais e outros dois aos adolescentes. O estudo foi transversal aninhado ao acompanhamento de 2004-2005 da coorte de nascimentos de 1993 em Pelotas, Rio Grande do Sul, Brasil. Pais ou responsáveis responderam à questão: "Comparando com a maioria das crianças da mesma idade, o(a Sr(a. diria que o seu filho faz mais exercícios que elas, menos exercícios que elas ou a mesma quantidade que elas?". Questão análoga foi aplicada aos adolescentes. Os adolescentes também responderam a um questionário mais detalhado sobre a prática de atividades físicas. A concordância entre os questionários foi avaliada pelo teste kappa ponderado. Um total de 4.254 adolescentes e responsáveis responderam aos questionários. Os valores de kappa indicaram concordância baixa para quaisquer das comparações (kappa < 0,33 para todas as análises. A mensuração de atividade física em adolescentes é complexa e os instrumentos disponíveis devem ser

  8. Sedentary behavior in adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Comportamento sedentário em adolescentes: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Directory of Open Access Journals (Sweden)

    Samuel C. Dumith

    2010-10-01

    Full Text Available The aim of this study was to estimate the prevalence of sedentary behavior and investigate associated factors in adolescents 11 years of age from the 1993 birth cohort in Pelotas, Rio Grande do Sul State, Brazil. Sedentary behavior was investigated with a questionnaire, and was defined as spending more than two hours per day watching television, playing videogames, or using the computer. Of the 4,452 adolescents interviewed, 98% reported watching television, 44% playing videogames, and 22% using the computer. The average time spent on each of these electronic media was 197, 36, and 17 minutes per day, respectively. Prevalence of sedentary behavior was 79.7% (95%CI: 78.6; 80.9 and showed a positive association with socioeconomic level and nutritional status and a negative association with well-being. These 11-year-olds spent extensive time at TV viewing, videogames, and the computer. Special attention should be given to the most exposed groups of adolescents, including the more affluent, overweight, and those with limited schooling.O objetivo deste estudo foi determinar a prevalência e investigar os fatores associados ao comportamento sedentário em adolescentes de 11 anos, pertencentes à coorte de nascimentos de 1993 de Pelotas, Rio Grande do Sul, Brasil. O comportamento sedentário foi coletado por meio de questionário, e definido como ficar mais de duas horas por dia assistindo à televisão, jogando videogame ou usando computador. Dos 4.452 adolescentes entrevistados, 98% assistiam à televisão, 44% jogavam videogame e 22% usavam computador. O tempo médio na frente de cada um desses meios eletrônicos foi, respectivamente, 197, 36 e 17 minutos por dia. A prevalência de comportamento sedentário foi de 79,7% (IC95%: 78,6; 80,9, e teve uma associação positiva com nível socioeconômico e com estado nutricional, e negativa com a escala de bem-estar. O tempo despendido em atividades como ver televisão, jogar videogame e usar computador

  9. Resting pulse rate among adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Frequência do pulso de repouso em adolescentes: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Directory of Open Access Journals (Sweden)

    Pedro C. Hallal

    2010-10-01

    Full Text Available The aim of this study was to describe resting pulse rate and associated factors among adolescents. This was a cross-sectional analysis nested in a prospective cohort study, including 4,452 adolescents born in Pelotas, Rio Grande do Sul State, Brazil in 1993, representing 87.5% of the original cohort. Pulse rate was measured with an electronic device at the beginning and end of the interview, and the mean value was used in the analyses. Mean pulse rate was 78.4bpm (SD = 11.0 in the total sample, 76.5bpm (SD = 10.7 in boys, and 80.2bpm (SD = 10.9; p O objetivo do estudo foi descrever a freqüência do pulso de repouso em adolescentes e avaliar variáveis associadas. Trata-se de análise transversal aninhada a um estudo de coorte prospectivo, incluindo 4.452 adolescentes nascidos em Pelotas, Rio Grande do Sul, Brasil, em 1993, os quais representam 87,5% da coorte original. A freqüência do pulso foi mensurada no início e ao final da entrevista com aparelho digital, sendo o valor médio utilizado nas análises. O valor médio da freqüência do pulso foi de 78,4bpm (DP = 11,0, sendo de 76,5bpm (DP = 10,7 nos meninos e 80,2bpm (DP = 10,9; p < 0,001 nas meninas. Os adolescentes com pele preta apresentaram valores mais baixos da freqüência do pulso. Houve uma forte associação positiva entre pressão arterial e freqüência do pulso. O escore de atividade física associou-se inversamente com a freqüência do pulso somente na análise bruta. Valores elevados de freqüência do pulso estão fortemente relacionados com valores elevados de pressão arterial, sendo ambas variáveis preditoras do risco de doenças crônicas na vida adulta.

  10. RS trigger based relaxation oscillator for temperature measurement circuit

    Institute of Scientific and Technical Information of China (English)

    ZOU Zhi-ge; ZOU Xue-cheng; JIAN Wen-xiang; LEI Jian-ming

    2008-01-01

    Resistance-to-time converter is always used for digital temperature measurement. An reset-set (RS) trigger based, relaxation oscillator based temperature measurement circuit, which is used to convert the change of thermistor sensor into a frequency signal for later processing, has been presented in this article. The RS trigger, which is composed of two inverters designed with distinct logical transition threshold voltages by changing the metal-oxide-semiconductor (MOS) transistor gains, has the same function as the Schmitt trigger in the relaxation oscillator. The advantage of the RS trigger based Schmitt trigger is that it reduces the dependence to supply voltage, chip temperature, and process variation. This temperature measurement circuit has been applied in a clinical thermometer chip that can measure temperature to an accuracy of better than 0.05℃ down to 1.1 V battery voltage. It is fabricated in 0.5double metal single poly complementary MOS (CMOS) process.

  11. Polymorphisms rs12998 and rs5780218 in KiSS1 Suppressor Metastasis Gene in Mexican Patients with Breast Cancer

    Directory of Open Access Journals (Sweden)

    Edhit Guadalupe Cruz Quevedo

    2015-01-01

    Full Text Available Aims. KiSS1 is a metastasis suppressor gene associated with inhibition of cellular chemotaxis and invasion attenuating the metastasis in melanoma and breast cancer cell lines. Along the KiSS-1 gene at least 294 SNPs have been described; however the association of these polymorphisms as genetic markers for metastasis in breast cancer studies has not been investigated. Here we describe two simple PCR-RFLPs protocols to identify the rs5780218 (9DelT and the rs12998 (E20K KiSS1 polymorphisms and the allelic, genotypic, and haplotypic frequencies in Mexican general population (GP and patients with benign breast disease (BBD or breast cancer (BC. Results. The rs5780218 polymorphism was individually associated with breast cancer (P=0.0332 and the rs12998 polymorphism shows statistically significant differences when GP versus case (BC and BBD groups were compared (P<0.0001. The H1 Haplotype (G/- occurred more frequently in BC group (0.4256 whereas H2 haplotype (G/T was the most prevalent in BBD group (0.4674. Conclusions. Our data indicated that the rs5780218 polymorphism individually confers susceptibility for development of breast cancer in Mexican population and a possible role as a genetic marker in breast cancer metastasis for H1 haplotype (Wt/variant in KiSS1 gene must be analyzed in other populations.

  12. THE HISTORY OF LABORATORY ANIMALS AND THE 3RS

    DEFF Research Database (Denmark)

    Alstrup, Aage Kristian Olsen

    This talk will give an introduction to the history of the use of laboratory animals with focus on the history of the three Rs (3Rs). We will see how animal experimentation has been performed early in our civilization, and how the suffering of animals has been justified. This will include Rene...... Descartes´s mechanical view of animals in the seventeenth century, and Charles Darwin's ambivalent relationship to animal experimentation, which he views as cruel but necessary. In the 1870s the Danish Foundation for Protection of Animals (“Dyrenes Beskyttelse”) and Professor Peter Panum discussed the use...

  13. Testing for Parameter Instability using the R/S Statistic

    OpenAIRE

    Michael Harrison; Glenn Treacy

    1998-01-01

    This paper explores the use of the R/S statistic as a means of checking for parameter instability. The nature and properties of the statistic are described, and its behaviour and power in the context of three situations of structural change are examined. The results suggest that the R/S statistic has an ability to detect shifts in means and changes in the intercept of a regression relationship. Moreover, it is more powerful than the OLS variant of the well known cumulative sum of squares resi...

  14. Design of an Active Photoelectric Isolating RS232/RS485 Converter%一种有源光电隔离RS232/RS485转换器设计

    Institute of Scientific and Technical Information of China (English)

    叶鑫; 李文魁; 高敬东; 钟斌

    2015-01-01

    为了提高转换器的抗干扰能力,根据现场应用环境,设计了一种抗干扰能力较强的有源光电隔离RS232/RS485接口转换电路.介绍了转换器的各电路原理图.测试表明,该转换器结构简单、抗干扰能力强、工作可靠,具有很强的应用价值.

  15. Validation of Omron RS8, RS6, and RS3 home blood pressure monitoring devices, in accordance with the European Society of Hypertension International Protocol revision 2010

    Directory of Open Access Journals (Sweden)

    Takahashi H

    2013-05-01

    Full Text Available Hakuo Takahashi, Masamichi Yoshika, Toyohiko YokoiDepartment of Clinical Sciences and Laboratory Medicine, Kansai Medical University, Hirakata, Osaka, JapanBackground: Allowing patients to measure their blood pressure at home is recognized as being of clinical value. However, it is not known how often these measurements are taken correctly. Blood pressure monitors for home use fall into two types based on the position of the cuff, ie, at the upper arm or the wrist. The latter is particularly convenient, as measurements can be taken fully clothed. This study aimed to evaluate the performance of the wrist-type blood pressure monitors Omron RS8 (HEM-6310F-E, Omron RS6 (HEM-6221-E, and Omron RS3 (HEM-6130-E.Methods: A team of three trained doctors validated the performance of these devices by comparing the measurements obtained from these devices with those taken using a standard mercury sphygmomanometer. All the devices met the validation requirements of the European Society of Hypertension International Protocol revision 2010.Results: The difference in blood pressure readings between the tested device and the standard mercury sphygmomanometer was within 3 mmHg, which is acceptable according to the European Society of Hypertension guidelines.Conclusion: All the home devices tested were found to be suitable for measuring blood pressure at home because their performance fulfilled the requirement of the guidelines.Keywords: blood pressure, device, European Society of Hypertension, guideline, measurement, validation

  16. USB-RS 232转换卡的设计与实现%Design and Realization 0f USB-RS232 Converter Card

    Institute of Scientific and Technical Information of China (English)

    赖彪; 金海鹰; 贾惠芹

    2011-01-01

    RS 232总线的数据传输速率相比,USB的传输速率高迭480 Mb/s,因此很多计算机的RS 232串行接口都被USB接口所替换,但是很多仪器仪表、控制终端、远程终端等设备的接口还是沿用RS 232.为解决两个接口之间的转换,设计并研制了USB-RS 232接口转换卡.从USB和RS 232通信协议出发,详细介绍USB-RS 232转换卡的设计原理,并以CH341T芯片为例,设计并制作了USB-RS 232转换卡.利用研制的USB-RS 232转换卡连接具有RS 232接口的温湿度传感器,在运行监控程序后,传感器运行稳定,能正确显示温湿度数据,且表明该转换卡可成功地实现RS 232接口与USB接口的转换.%Compared with RS232 bus.USB (universal serial bus) transfer rate can arrive at 480 Mbps.Therefore, many RS232 serial interface has been replaced by USB interface recently, but the RS232 serial interface is still reserved in some equipments, such as instruments, controllers and remote ternunals.A USB-RS232 converter card is designed and realized with CH341T chip to solve this conversion problem between USB and RS-232 bus.The principle of USB-RS232 converter card is discussed in this paper through studying the USB and RS232 protocol.USB-RS232 converter card can be connected with a temperature-humidity sensor through a RS232 interface.The testing result shows that USB-RS232 converter card runs normally, can display the temperature and humidity data correctly, and the design principle of USB-RS232 converter card is correct.

  17. Association Study of Polymorphisms rs4552569 and rs17095830 and the Risk of Ankylosing Spondylitis in a Taiwanese Population

    OpenAIRE

    Wei, James Cheng-Chung; Hsu, Yu-Wen; Hung, Kuo-Sheng; Wong, Ruey-Hong; Huang, Chun-Huang; Liu, Yi-Tzu; Guo, Yuh-Cherng; Ikegawa, Shiro; Chang, Wei-Chiao

    2013-01-01

    Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. However, the development of anklosing spondylitis is unclear. Human leukocyte antigens HLA-B27 and ERAP1 have been widely reported to be associated with AS susceptibility. A recent genome-wide association study (GWAS) showed that two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569) and within ANO6 at 12q12 (rs17095830) contribute to the risk of AS in Han Chinese. ...

  18. RS Components推出PCB转换器模块

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    RS Components(RS)宣布为SketchUp工具推出其新版PCB Converter(印刷电路板文件转换模块),便于设计人员将中间数据格式(Intermediate Data Format,IDF)文件输入到Google SketchUp内。

  19. 7q21-rs6964587 and breast cancer risk

    DEFF Research Database (Denmark)

    Milne, Roger L; Lorenzo-Bermejo, Justo; Burwinkel, Barbara;

    2011-01-01

    Using the Breast Cancer Association Consortium, the authors previously reported that the single nucleotide polymorphism 7q21-rs6964587 (AKAP9-M463I) is associated with breast cancer risk. The authors have now assessed this association more comprehensively using 16 independent case-control studies....

  20. Rescaled range (R/S) analysis on seismic activity parameters

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The rescaled range (R/S) analysis, proposed by Hurst, is a newstatistical method. Being different from traditional statistical method, R/S analysis can provide the information of maximum fluctuation (range) of statistical parame-ters. At present paper, several modern instrumental earthquake catalogues in different spatial scale, temporal scale, and with different seismic activity background are studied, and R/S method is used to analyze the variation of range of seismic parameters such as earthquake frequency, and earthquake time interval. For different seismic parameters, the ratio of range to standard deviation - R/S is a power law function of the length of time, and the exponent H of power law is always greater than 0.5. As we know, H=0.5 is the characteristics of all ideal random processes. Our results indicate that earthquake series is not an ideal Poisson process, on the contrary, the earth-quake as a phenomenon bears dual characteristics of randomicity and regularity, and the greater H departs from 0.5, the more regularity the time series will show, and vice versa. With time scale changing, one can give the conserva-tive estimate of the fluctuation, which might occur in a relatively long time scale, only by using the limited and known time records.

  1. CAT bags orders worth Rs 90 Crore from EU

    CERN Multimedia

    2002-01-01

    "Orders to the tune of Rs 90 crore have been received by Indore-based Centre for Advanced Technology (CAT) from laboratories in the European Union (EU) and more orders are likely to follow in the near future, according to Pune-based Patel Analog and Digital Measurement Company (PADMCO) director Madhu Patel" (1/2 page).

  2. RS485 optical router for HIRFL-CSR

    International Nuclear Information System (INIS)

    A communication equipment-RS485 optical router has been developed to satisfy requirements of control system communication network of HIRFL-CSR (Heavy Ion Research Facility at Lanzhou-Cooling Storage Ring). The equipment is compatible with multiple communication protocols, such as Ethernet, RS232 and RS485 standard. It can be used to setup the RS485 communication network quickly and connected to the Ethernet easily. The fiber optical interface is introduced to facilitate the connection with the network of industrial Fiber Optics Communication (FOC), which expands the application field of the equipment in a large extent. This paper introduces the details of the equipment, including the design of the circuit and software, features of the equipment and how it works in the whole control system network. Its application in the HIRFL-CSR control system shows that the equipment is in accordance with the general requirement of automatic control communication system. It could also be used in other industrial automatic control fields. (authors)

  3. Extended Methodology of RS Design and Instances Based on GIP

    Institute of Scientific and Technical Information of China (English)

    Qian-Hong Wu; Bo Qin; Yu-Min Wang

    2005-01-01

    Abe et al. proposed the methodology of ring signature (RS) design in 2002 and showed how to construct RS with a mixture of public keys based on factorization and/or discrete logarithms. Their methodology cannot be applied to knowledge signatures (KS) using the Fiat-Shamir heuristic and cut-and-choose techniques, for instance, the Goldreich KS.This paper presents a more general construction of RS from various public keys if there exists a secure signature using such a public key and an efficient algorithm to forge the relation to be checked if the challenges in such a signature are known in advance. The paper shows how to construct RS based on the graph isomorphism problem (GIP). Although it is unknown whether or not GIP is NP-Complete, there are no known arguments that it can be solved even in the quantum computation model. Hence, the scheme has a better security basis and it is plausibly secure against quantum adversaries.

  4. Is there the radion in the RS2 model ?

    CERN Document Server

    Smolyakov, M N; Smolyakov, Mikhail N.; Volobuev, Igor P.

    2004-01-01

    We analyse the physical boundary conditions at infinity for metric fluctuations and gauge functions in the RS2 model with matter on the brane. We argue that due to these boundary conditions the radion field cannot be gauged out in this case. Thus, it represents a physical degree of freedom of the model.

  5. Trends in socioeconomic inequalities in anthropometric status in a population undergoing the nutritional transition: data from 1982, 1993 and 2004 pelotas birth cohort studies

    Directory of Open Access Journals (Sweden)

    Matijasevich Alicia

    2012-07-01

    Full Text Available Abstract Background Socioeconomic inequalities in child nutrition may change rapidly over time, particularly in populations undergoing the nutrition transition. Yet, the few available studies are repeated cross-sectional surveys. By studying three prospective birth cohorts in the same city over a period of more than two decades, we describe secular trends in overweight and stunting at different ages, according to socioeconomic position. Methods Population-based birth cohort studies were launched in the city of Pelotas (Brazil in 1982, 1993 and 2004, with follow-up visits at twelve, 24 and 48 months. Children were weighed and measured at every visit. Z-scores of length/height-for-age and body mass index-for-age were calculated using the WHO Child Growth Standards. The slope and relative indices of inequality, based on family income quintiles, were estimated for each follow-up visit. Results Between the 1982 and 2004 cohorts, stunting among four-year-olds declined (from 10.9% to 3.6%, while overweight increased (from 7.6% to 12.3%. In every visit, stunting prevalence was inversely related to income. Both absolute and relative inequalities declined over time; among four-year-olds stunting dropped from 26.0% in the 1982 cohort to 6.7% in the 2004 cohort in the poorest group, while in the richest group stunting prevalence dropped from 2.7% in 1982 to 1.1% in the 2004 cohort study. The secular trend towards increased overweight was evident for four-year-olds, in almost all socioeconomic groups, but not among one and two-year-olds. Among four-year old children, overweight prevalence increased in all income quintiles, by 130% in the middle-income group, 64% in the poorest and 41% in the richest group. Conclusions The decline in stunting is remarkable, but the increase in overweight among four-year olds – particularly among the poorest and the middle-income groups– requires concerted efforts to prevent the long term consequences of child overweight.

  6. Peraluminous leucogranites of the Cordilheira Suite: A record of Neoproterozoic collision and the generation of the Pelotas Batholith, Dom Feliciano Belt, Southern Brazil

    Science.gov (United States)

    Philipp, Ruy Paulo; Massonne, Hans-Joachim; de Campos, Roberto Sacks

    2013-04-01

    The Cordilheira Suite is comprised of peraluminous granites that constitute, together with the Quitéria granite, the beginning of the formation of the Pelotas Batholith in the central portion of the Dom Feliciano Belt. The batholith is composed of seven granitic suites with minor occurrences of gabbro, diorite and subvolcanic rocks. Its evolution between 650 and 550 million years ago is characterised by a ranging from metaluminous to peraluminous rocks and from calc-alkaline to alkaline and peralkaline series. The Cordilheira Suite is composed of the Cordilheira, Arroio Francisquinho, Butiá and Três Figueiras granites, which contain muscovite and/or biotite, with the following accessory minerals: tourmaline, garnet, sillimanite, apatite, zircon, monazite and ilmenite. The granitic bodies are elongate; their ascent and emplacement were controlled by high-angle shear zones oriented at N45-70°E. They have mylonitic structures with magmatic foliation accompanied by a low-angle stretching lineation, indicating that these bodies were emplaced under syn-kinematic conditions during a transcurrent event. The granites have high-K calc-alkaline affinity and are peraluminous. The LILE and REE contents are low. The K2O/Na2O and CaO/Na2O ratios are approximately 1 and less than 0.3, respectively. Pseudosections calculated using the Perple X program suggests that the granites were formed at partial melting temperatures between 740 and 820 °C and pressure between 8.5 and 9 kbar. Petrographic and chemical data suggest that the magmas were generated by the partial melting of the migmatitic pelitic gneisses of the Várzea do Capivarita Complex and, to a lesser degree, orthogneisses of the Arroio dos Ratos Complex, which left a granulitic residue. UHT conditions of granulite facies metamorphism were recorded in the Várzea do Capivarita paragneisses by mineral paragenesis and indicate that temperatures between 900 and 1000 °C and pressures between 4 and 8 kbar were required for

  7. iNOS基因rs10459953/rs1060822多态性与低氧训练效果的关联性研究%Association between polymorphisms rs10459953/rs1060822 gene and variation in response to hypoxia training

    Institute of Scientific and Technical Information of China (English)

    毛颖颖; 汪洪波; 刘海平

    2014-01-01

    目的:选取低氧反应基因——诱导型一氧化氮合酶(inducible nitric oxide synthase,iN-OS)基因序列上rs10459953、rs1060822单核苷酸多态性(single nucleotide polymorphism,SNP)位点,研究其与低氧训练后生理表型指标关联性.方法:采用关联研究方法(Association-Study),聚合酶链反应-限制片段长度多态性(PCR-RFLP)实验解析技术,选取35名健康受试者在模拟海拔2500 m高度进行4周高住-高练-低训(living high-exercise high-training low,Hi-Hi-Lo).研究iNOS基因SNP rs10459953和SNPrs1060822与低氧训练后最大摄氧量(maximal oxygen uptake,VO2 max)、血红蛋白(hemoglobin,Hb)、红细胞数(red blood cell,RBC)等生理表型指标关联性.结果:1)4周低氧训练后,SNP rs10459953不同基因型之间VO2 max、Hb、RBC变化量均无显著性差异.2)4周低氧训练后,SNP rs1060822不同基因型间Hb、RBC变化量有统计学意义(P<0.05),其中CT基因型受试者Hb、RBC显著增加(P<0.05),且在低氧环境下定量负荷实验中,SNP rs1060822的CT基因型受试者低氧训练后期SpO2动态曲线显著高于初期(P<0.05).结论:iNOS基因SNP rs1060822与低氧训练后血象指标存在一定关联性,CT基因型表现出一定优势.

  8. The Two-Component System CprRS Senses Cationic Peptides and Triggers Adaptive Resistance in Pseudomonas aeruginosa Independently of ParRS

    DEFF Research Database (Denmark)

    Fernandez, Luca; Jenssen, Håvard; Bains, Manjeet;

    2012-01-01

    through ParRS. Here, we report the identification of a new two-component system, CprRS, which, upon exposure to a wide range of antimicrobial peptides, triggered the expression of the LPS modification operon. Thus, mutations in the cprRS operon blocked the induction of the arn operon in response to...... several antimicrobial peptides independently of ParRS but did not affect the response to low Mg2+. Distinct patterns of arn induction were identified. Thus, the responses to polymyxins were abrogated by either parR or cprR mutations, while responses to other peptides, including indolicidin, showed...... differential dependency on the CprRS and ParRS systems in a concentration-dependent manner. It was further demonstrated that, following exposure to inducing antimicrobial peptides, cprRS mutants did not become adaptively resistant to polymyxins as was observed for wild-type cells. Our microarray studies...

  9. Association of rs10757274 and rs2383206 Polymorphisms on 9p21 locus with Coronary Artery Disease in Turkish Population

    Science.gov (United States)

    Okyay, Kaan; Yılmaz, Akın; Şahinarslan, Asife; Yar Sağlam, Atiye Seda; Eyiol, Azmi; Bolayır, Hasan Ata; Sezenöz, Burak; Menevşe, Sevda; Çengel, Atiye

    2016-01-01

    Background and Objectives Genetic predisposition is an important risk factor for coronary artery disease (CAD). In this study, we aimed to evaluate the impact of rs10757274 and rs2383206 polymorphisms in chromosome 9p21 on presence and severity of CAD in a Turkish population. Subjects and Methods A total of 646 patients who underwent coronary angiography were included in this study. Coronary vessel score and Gensini score were calculated to assess the angiographic severity of CAD. Alleles of AA, AG, and GG were determined for rs10757274 (polymorphism-1) and rs2383206 (polymorphism-2) polymorphisms located in chromosome 9p21 from the blood samples. Results There was a significant difference between the alleles in polymorphism-1 in the presence of coronary artery disease (38.9% in AA, 48.0% in GG and 56.4% in AG, p=0.017). However, there was no difference between the alleles in polymorphism-2. According to vessel scores, there was a significant difference between the alleles in polymorphism-1 (AA 0.71±1.04, GG 0.88±1.07, AG 1.06±1.12, p=0.018). In polymorphism-2, vessel scores did not show a difference between the alleles. In polymorphism-1, there was a significant difference in Gensini score (p=0.041). Gensini scores did not differ between the alleles in polymorphism-2 (p>0.05 for all). In multivariate analyses, none of the alleles was an independent factor for presence of CAD. Conclusion The presence of rs10757274 polymorphism including AG allele in chromosome 9p21 was related to CAD. However, this relationship was not independent of other cardiovascular risk factors. PMID:27721851

  10. single nucleotide Polymorphisms rs2227284, rs2243283 and rs2243288 in the Il-4 Gene show no association with susceptibility to Chronic Hepatitis B in a Chinese Han Population

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    Objective To investigate the relationship between single nucleotide polymorphisms (SNPs) of the interleukin-4 (IL-4) gene and outcome of hepatitis B virus (HBV) infection in a Chinese Han population. Methods Total of 501 patients with chronic hepatitis B virus (HBV) infection and 301 controls with self-limiting HBV infection were studied. Three tag SNPs in the IL-4 gene (rs2227284G/T, rs2243283C/G and rs2243288A/G) were genotyped by the Multiplex snapshot technique. The genotype and allele frequencies were calculated and analyzed. Results The three SNPs showed no significant genotype/allele associations with chronic HBV infection. Overall allele P values were:rs2227284, P=0.655, odds ratio (OR) [95%conifdence interval (CI)]=1.070 (0.793-1.445);rs2243283, P=0.849, OR (95%CI)=0.976 (0.758-1.257);rs2243288, P=0.659, OR (95%CI) = 1.060 (0.818-1.375). Overall genotype P values were: rs2227284, P = 0.771; rs2243283, P = 0.571;rs2243288, P=0.902. There were no statistically signiifcant differences between patients with chronic HBV infection and controls. Haplotypes generated by these three SNPs also had no signiifcant differences between the two groups. Conclusions The three tag SNPs of IL-4 were not associated with the outcome of HBV infection in the Han Chinese population.

  11. Creating and maintaining social networks: women’s participation in Basque pilota. [Creación y mantenimiento de redes sociales: participación de mujeres en pelota vasca].

    Directory of Open Access Journals (Sweden)

    Uxue Fernandez-Lasa

    2015-04-01

    Full Text Available Basque pilota is a traditional sport played mainly by men. A project emerged in 2005 to promote female participation: Emakumea Pilotari (Woman pelota player. In this article we present the main points that emerged from an ethnographic study of the social relationships that playing Basque pilota can provide. The study was carried out in 2011-2012 season with a purposive sample of 28 adult women Basque pilota players (pilotaris (between 22 and 60 years old. 26 participants were pilotaris in recreational groups and the other two were their trainers. The results suggest that a sense of community, team membership, the development of a general reciprocity and group security are the most important aspects for players. A sense of community is the fundamental reason why they practise this sport. The group as a whole is the top priority. Female pilotaris share the desire to relate to each other as women, build relationships, create bonds and help each other. Resumen La pelota vasca es un deporte tradicional practicado mayoritariamente por hombres. En 2005 se puso en marcha un proyecto para promover la participación de las mujeres: Emakumea Pilotari (Mujer Pelotari. En este artículo se presentan los hallazgos de un estudio etnográfico llevado a cabo durante una temporada en torno a las relaciones sociales que genera jugar a pelota vasca. La investigación se realizó con una muestra intencionada de 28 mujeres pelotaris adultas (entre 22 y 60 años, de las cuales 26 eran participantes de un programa recreativo y dos entrenadoras. Los resultados indican que los aspectos más importantes para las participantes son el sentimiento de comunidad, ser miembro de un grupo, el desarrollo de la reciprocidad general y la seguridad que da el grupo. La comunidad es la razón fundamental para practicar este deporte, ya que el grupo es la mayor prioridad. Las mujeres pelotaris comparten el deseo de relacionarse entre ellas como mujeres, construir relaciones, crear

  12. Utilização de adoçantes dietéticos entre adultos em Pelotas, Rio Grande do Sul, Brasil: um estudo de base populacional Use of diet sweeteners by adults in Pelotas, Rio Grande do Sul State, Brazil: a population-based study

    Directory of Open Access Journals (Sweden)

    Roberta de Vargas Zanini

    2011-05-01

    Full Text Available Estudo de base populacional avaliou o uso de adoçantes dietéticos na população com idade ≥ 20 anos, residente na zona urbana do Município de Pelotas, Rio Grande do Sul, Brasil. A coleta de dados ocorreu entre janeiro e julho de 2010, e 2.732 indivíduos foram entrevistados. Além das questões específicas quanto ao uso de adoçante dietético, foram coletadas informações sobre características demográficas, socioeconômicas e de saúde. Para as análises estatísticas, foram utilizados testes qui-quadrado de heterogeneidade e de tendência linear. A prevalência de uso de adoçante dietético foi 19% (IC95%: 17,1; 20,9, sendo 3,7 vezes maior entre idosos do que entre aqueles com 20-29 anos de idade. Nível econômico e estado nutricional apresentaram associação direta e significativa com o desfecho. Quase 98% da amostra utilizou adoçantes na forma líquida, sendo os mais consumidos (89,2% aqueles constituídos por sacarina e ciclamato de sódio. A mediana de ingestão diária foi 10 gotas (P25; P75 = 6; 18, entre usuários de adoçante líquido, ou 1,5 sachet (P25; P75 = 1; 4, para adoçante em pó. O uso de adoçante dietético foi maior entre mulheres e idosos.This population-based study evaluated the use of diet sweeteners by adults (> 20 years in Pelotas, Rio Grande do Sul State, Brazil. Data were collected from January to July 2010 (n = 2,732. Besides specific questions on diet sweeteners, demographic, socioeconomic, and health characteristics were recorded. Heterogeneity and linear trend chi-square tests were used for the statistical analysis. Prevalence of sweetener use was 19% (95%CI: 1.1-20.9, and was 3.7 times higher in elderly individuals as compared to 20-29-year-olds. Economic level and nutritional status were significantly associated with sweetener use. Nearly 98% of the sample used liquid sweeteners; the most frequently consumed (89.2% were those containing saccharin or sodium cyclamate. Average intake was 10 drops

  13. Validation of the Edinburgh Postnatal Depression Scale (EPDS in a sample of mothers from the 2004 Pelotas Birth Cohort Study Validação da Escala de Depressão Pós-natal de Edinburgo (EPDS em uma amostra de mães da Coorte de Nascimento de Pelotas, 2004

    Directory of Open Access Journals (Sweden)

    Iná S. Santos

    2007-11-01

    Full Text Available The aim of this study was to evaluate the Edinburgh Postnatal Depression Scale (EPDS for screening and diagnosis of postpartum depression. Three months after delivery, EPDS was administered to 378 mothers from the 2004 Pelotas Birth Cohort Study, Rio Grande do Sul State, Brazil. Up to 15 days later, mothers were re-interviewed by mental health care professionals using a semi-structured interview based on ICD-10 (gold standard. We calculated the sensitivity and specificity of each cutoff point, and values were plotted as a receiver operator characteristic curve. The best cutoff point for screening postpartum depression was > 10, with 82.6% (75.3-89.9% sensitivity and 65.4% (59.8-71.1% specificity. For screening moderate and severe cases, the best cutoff point was > 11, with 83.8% (73.4-91.3% sensitivity and 74.7% (69.4-79.5% specificity. For diagnosis, EPDS was valid only for prevalence of postpartum depression in the 20-25% range, with 60% PPV for the > 13 cutoff point (59.5% sensitivity; 88.4% specificity. The specificities and PPVs for all cutoff points were below those reported by other authors. Small numbers and the calculation of PPV in samples with overrepresentation of cases in the majority of studies appear to account for these differences.Avaliar a validade da Escala de Depressão Pós-natal de Edimburgo (EPDS para rastreamento e diagnóstico de depressão pós-parto. Três meses pós-parto, a EPDS foi aplicada a 378 mães da Coorte de Nascimentos de Pelotas, Rio Grande do Sul, Brasil, em 2004. Até 15 dias após, as mães foram reentrevistadas por profissionais de saúde mental utilizando-se questionário semi-estruturado baseado na CID-10 (padrão-ouro. Calculamos sensibilidade e especificidade de cada ponto de corte e construiu-se curva ROC. Melhor ponto de corte para rastreamento foi > 10 (sensibilidade 82,6%, 75,3%-89,9%; especificidade 65,4%, 59,8%-71,1%. Para rastrear casos moderados e graves, melhor ponto de corte foi > 11, com

  14. AS/RS based yard and yard planning

    Institute of Scientific and Technical Information of China (English)

    Ya-hong HU; Zheng-dong ZHU; Wen-jing HSU

    2008-01-01

    In this paper,we apply the split-platform automated storage/retrieval systems (SP-AS/RSs) (Hu et al.,2005) to store containers in the yard to improve the yard performance and to increase the utilization of the yard space.The layout of an SP-AS/RS based yard is described in detail.To achieve an efficient operation,we present a novel yard space allocation policy called the 'second-carrier-based allocation policy',which can help to alleviate the out-of-sequence problem of containers and the congestion of vehicles at the AS/RS racks.Different allocation policies are compared by an integrated container terminal simulation system.The simulation results show that the second-carrier-based policy is very efficient and has the potential to offer high terminal performance.

  15. Radiation Dry Bias of the Vaisala RS92 Humidity Sensor

    Science.gov (United States)

    Vomel, H.; Selkirk, H.; Miloshevich, L.; Valverde-Canossa, J.; Valdes, J.; Kyro, E.; Kivi, R.; Stolz, W.; Peng, G.; Diaz, J. A.

    2007-01-01

    The comparison of simultaneous humidity measurements by the Vaisala RS92 radiosonde and by the Cryogenic Frostpoint Hygrometer (CFH) launched at Alajuela, Cosla Rica, during July 2005 reveals a large solar radiation dry bias of the Vaisala RS92 humidity sensor and a minor temperature-dependent calibration error. For soundings launched at solar zenith angles between 10" and 30 , the average dry bias is on the order of 9% at the surface and increases to 50% at 15 km. A simple pressure- and temperature-dependent correction based on the comparison with the CFH can reduce this error to less than 7% at all altitudes up to 15.2 km, which is 700 m below the tropical tropopause. The correction does not depend on relative humidity, but is able to reproduce the relative humidity distribution observed by the CFH.

  16. Predicting pKa for proteins using COSMO-RS

    DEFF Research Database (Denmark)

    Andersson, Martin Peter; Jensen, Jan Halborg; Stipp, Susan Louise Svane

    2013-01-01

    We have used the COSMO-RS implicit solvation method to calculate the equilibrium constants, pKa, for deprotonation of the acidic residues of the ovomucoid inhibitor protein, OMTKY3. The root mean square error for comparison with experimental data is only 0.5 pH units and the maximum error 0.8 p......H units. The results show that the accuracy of pKa prediction using COSMO-RS is as good for large biomolecules as it is for smaller inorganic and organic acids and that the method compares very well to previous pKa predictions of the OMTKY3 protein using Quantum Mechanics/Molecular Mechanics. Our approach...

  17. Spectrophotometry of RS Oph during the nebular phase

    Energy Technology Data Exchange (ETDEWEB)

    Bohigas, J.; Echevarria, J. (Universidad Nacional Autonoma de Mexico, Mexico City (Mexico). Inst. de Astronomia); Diego, F. (University Coll., London (UK). Dept. of Physics and Astronomy); Sarmiento, J.A. (Universidad Nacional Autonoma de Mexico, Mexico City (Mexico). Facultad de Ciencias)

    1989-06-15

    Blue-wavelength spectroscopic observations of RS Oph, 201 day after the 1985 outburst are presented. An analysis of the TiO bands indicates a spectral type M4III for the secondary and a distance of 2 kpc to the system. The system of forbidden lines is excited by a shock wave, whereas Balmer emission is mainly produced by photoionization. The source of photons is probably residual thermonuclear burning occurring at the surface of the white dwarf. (author).

  18. Spectrophotometry of RS Oph during the nebular phase

    International Nuclear Information System (INIS)

    Blue-wavelength spectroscopic observations of RS Oph, 201 day after the 1985 outburst are presented. An analysis of the TiO bands indicates a spectral type M4III for the secondary and a distance of 2 kpc to the system. The system of forbidden lines is excited by a shock wave, whereas Balmer emission is mainly produced by photoionization. The source of photons is probably residual thermonuclear burning occurring at the surface of the white dwarf. (author)

  19. Approximating the distribution of the R/s statistic

    OpenAIRE

    Denis Conniffe; Spencer, John E.

    2000-01-01

    The R/s statistic, used for many years in hydrology, is increasingly employed in economics, although deficiencies in knowledge about its exact distribution have inhibited progress. Harrison and Treacy (1997) have described some applications and addressed distributional problems through Monte Carlo simulation, deriving close to exact significance test points for a range of sample values. But there remain advantages to algebraic approximations to the exact distribution in relaxing restrictions ...

  20. HDL IMPLEMENTATION OF ALGEBRAIC SOFT DECISION ALGORITHM FOR RS CODES

    OpenAIRE

    M. Revathy; Saravanan, R.

    2013-01-01

    Reed Solomon (RS) codes are widely used to detect and correct data errors in transmission andstorage systems. Hence it is used in many digital communication and storage devices. In existing systemReformulated inversion less Burst error correcting (RiBC) algorithm is used. But it lacks in speed,throughput & area. To overcome this Algebraic Soft Decision (ASD) algorithm is proposed. This Proposedalgorithm is based on Unified VLSI architecture for correcting burst errors as well as random errors...

  1. MOA-2010-BLG-523 : "Failed Planet" = RS CVn Star

    OpenAIRE

    Gould, A.; Yee, J. C.; Bond, I. A.; Udalski, A; Han, C; J\\xf8rgensen, U. G; Greenhill, J.; Tsapras, Y.; Pinsonneault, M. H.; Bensby, T.; Allen, W.; Almeida, L. A.; Bos, M.; Christie, G. W.; DePoy, D. L.

    2013-01-01

    The Galactic bulge source MOA-2010-BLG-523S exhibited short-term deviations from a standard microlensing light curve near the peak of an A [SUB]max[/SUB] ~ 265 high-magnification microlensing event. The deviations originally seemed consistent with expectations for a planetary companion to the principal lens. We combine long-term photometric monitoring with a previously published high-resolution spectrum taken near peak to demonstrate that this is an RS CVn variable, so that planetary microlen...

  2. Alkaline protease from Thermoactinomyces sp. RS1 mitigates industrial pollution.

    Science.gov (United States)

    Verma, Amit; Ansari, Mohammad W; Anwar, Mohmmad S; Agrawal, Ruchi; Agrawal, Sanjeev

    2014-05-01

    Proteases have found a wide application in the several industrial processes, such as laundry detergents, protein recovery or solubilization, prion degradation, meat tenderizations, and in bating of hides and skins in leather industries. But the main hurdle in industrial application of proteases is their economical production on a large scale. The present investigation aimed to exploit the locally available inexpensive agricultural and household wastes for alkaline protease production using Thermoactinomyces sp. RS1 via solid-state fermentation (SSF) technique. The alkaline enzyme is potentially useful as an additive in commercial detergents to mitigate pollution load due to extensive use of caustic soda-based detergents. Thermoactinomyces sp. RS1 showed good protease production under SSF conditions of 55 °C, pH 9, and 50 % moisture content with potato peels as solid substrate. The presented findings revealed that crude alkaline protease produced by Thermoactinomyces sp. RS1 via SSF is of potential application in silver recovery from used X-ray films. PMID:24122212

  3. AB200. Association of rs3129878 and rs498422in the HLA region with non-obstructive azoospermia in the Han Chinese population

    OpenAIRE

    Zou, Shasha; Song, Pingping; Chen, Tingting; Jianhua CHEN; He, Xiaojin; Xu, Peng(Academy of Mathematics and Systems Science, Chinese Academy of Sciences, 100190, Beijing, China); Liang, Ming; Luo, Kailing; Zhu, Xiaobin; Tian, Erpo; Du, Qiang; Wen, Zujia; Li, Zhiqiang; Wang, Meng; Sha, Yanwei

    2014-01-01

    Objective The previous genome-wide association study (GWAS) of non-obstructive azoospermia (NOA) in the Han Chinese populations identified two NOA-risk loci (rs498422 and rs3129878) within the HLA region, and provided strong evidence for the genetic influence of male infertility. A further case-control study found that only rs3129878 remained to be significantly associated with NOA in the Japanese population. Therefore, we conducted the association study to further validate whether the risk o...

  4. Assessing the search for and implementation of the Three Rs: a survey among scientists.

    NARCIS (Netherlands)

    Leenaars, M.; Savenije, B.; Nagtegaal, A.; Vaart, L. van der; Ritskes-Hoitinga, M.

    2009-01-01

    A survey among scientists into the current practice of searching for Replacement, Reduction and Refinement (Three Rs) alternatives, highlights the gap between the statutory required need to apply the Three Rs concept whenever possible and the lack of criteria for searching for Three Rs alternatives.

  5. [Anorexia nervosa with refeeding syndrome: prevention and treatment of RS].

    Science.gov (United States)

    Kasai, Makiko; Okajima, Yoshirou; Takano, Eisuke; Kato, Satoshi

    2009-01-01

    Refeeding syndrome (RS), seen in the early stages of anorexia nervosa (AN) treatment, has not been paid sufficient attention regarding its strong association with poor outcomes. This report describes a case of AN restriction type (AN-R) with sequent RS appearance despite the introduction of progressive and careful low-calorie nutrition, and discusses RS treatment. The patient was a 16-year-old female. She was first diagnosed with AN at the age of 14 when she went on a diet, admitted into pediatrics, and recovered: however, AN recurred after she started high school, and her weight decreased to 31.8 kg. She was admitted to pediatrics again, refused to receive treatment, discharged from the hospital, and introduced to our department. Soon after she came to us, her weight went down to 29.6 kg, and continued to decrease to 26.8 kg. She was recommended to receive inpatient care, but she firmly refused. A few days later, her experience of loss of consciousness made her agree to receive inpatient care. At this time, she was already weakened and had difficulty performing voluntary body movements as well as excretion. She was treated carefully and placed on 125 kcal/day. On the 6th day of treatment, severe liver damage was observed, her serum phosphorus level went down to 2.0 mg/dL, and she was diagnosed with RS. The lowest concentration of serum phosphorus observed was 1.3 mg/dL with blood abnormality and delirium; however, our strict management with intravascular phosphorus administration supported her increased dietary intake, and the patient was able to leave the hospital on the 54th day after admission. Based on this experience, the pathogenesis of RS was overviewed, and RS prevention as well as treatment was discussed. It has been reported that low phosphorus levels are observed in approximately one quarter of AN patients, and, thus, immediate action and treatment of hypophosphatemia are necessary when considering RS occurrence. In this study, the observed serum

  6. TLR4 rs1927911, but Not TLR2 rs5743708, Is Associated With Atherosclerotic Cerebral Infarction in the Southern Han Population

    OpenAIRE

    Song, Yanmin; Liu, Huarong; Long, Lili; Zhang, Ning; Liu, Yunhai

    2015-01-01

    Abstract The objective of this study was to explore the association of toll-like receptor (TLR) 4 rs1927911 and TLR2 rs5743708 with atherosclerotic cerebral infarction (ACI) and their effects on blood pressure, fasting blood glucose, and blood lipids in the Han population of Hunan Province. TLR4 rs1927911 and TLR2 rs5743708 were detected by polymerase chain reaction and restriction fragment length polymorphism in 170 patients with ACI and 149 healthy controls. Our results indicated that the g...

  7. Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development: an updated meta-analysis

    Science.gov (United States)

    Dai, Zhi-Ming; Zhang, Tian-Song; Lin, Shuai; Zhang, Wang-Gang; Liu, Jie; Cao, Xing-Mei; Li, Hong-Bao; Wang, Meng; Liu, Xing-Han; Liu, Kang; Li, Shan-Li; Dai, Zhi-Jun

    2016-01-01

    Single nucleotide polymorphisms (SNPs) in the interleukin-17 (IL-17) gene have been shown to be correlated with susceptibility to cancer. However, various studies report different results of this association. The aim of the present work was to clarify the effects of IL-17A G197A (rs2275913) and IL-17F T7488C (rs763780) polymorphisms on cancer risk. We performed systematic searches of the PubMed and CNKI databases to obtain relevant publications. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association of rs2275913 and rs763780 polymorphisms with cancer risk. Data were extracted from the selected studies, and statistical analysis was conducted using the STATA software. Our results indicated that rs2275913 and rs763780 polymorphisms significantly increase cancer risk, especially in gastric cancers. Subgroup analysis suggested the existence of a significant correlation between rs763780 polymorphism and cancer susceptibility in Caucasian populations. This updated meta-analysis confirms that rs2275913 and rs763780 polymorphisms are highly associated with increased risk for multiple forms of cancer. PMID:26843459

  8. RS485-GPIB Converter Design Based on TNT4882%基于TNT4882的RS485-GPIB转换器设计

    Institute of Scientific and Technical Information of China (English)

    梁芳芳; 李南安

    2012-01-01

    描述了基于TNT4882的RS485-GPIB转换器设计,利用单片机W77C032控制GPIB接口芯片TNT4882,实现了RS485网络与GPIB网络的数据互换。%This paper expands the RS485-GP/B converter design based on TNT4882, and uses SCM to control the GPIB interface chip TNT4882 for the implementation of the data exchange between RS485 and GPIB net.

  9. Physico-chemical, functional and structural properties of RS3/RS4 from kidney bean (Phaseolus vulgaris) cultivars.

    Science.gov (United States)

    Gani, Adil; Jan, Amreen; Shah, Asima; Masoodi, F A; Ahmad, Mudasir; Ashwar, Bilal Ahmad; Akhter, Rehana; Wani, Idrees Ahmed

    2016-06-01

    Starch isolated from four kidney bean cultivars (Yellow bean, Red bean, Black bean and White bean) were physically and chemically modified in order to prepare resistant starch (RS3/RS4). Following the Heat-moisture treatment (HMT) and Citric acid modification (CT) of the native starch, the amylose content got decreased whereas bulk and tapped density (g/ml) increased. Both HMT and CT reduced the swelling power and the solubility of native starch. Pasting temperature increased and peak, breakdown, final, and set-back viscosity decreased after both the modifications. Fourier Transform Infrared Spectroscopy (FTIR) analysis displayed peaks at 1020cm(-1) in HMT and 1724cm(-1) in CT starches. Differential Scanning Calorimetry (DSC) analysis revealed that samples were more stable after modification. X-ray diffraction (XRD) analysis revealed reordering of chain segments to more crystalline structure. These results suggested modifications resulted in starch with improved properties and could be a possible method for the RS preparation with better thermal stability. PMID:26976068

  10. rs6983267和rs1447295与北京地区前列腺癌的关联研究%Association between rs6983267 and rs1447295 and the risk of prostate cancer in Beijing Han population

    Institute of Scientific and Technical Information of China (English)

    蒲连美; 刘铭; 史晓红; 魏东; 王建业; 杨泽

    2012-01-01

    OBJECTIVE: To investigate the association of the two common single nucleotide polymorphisms (SNPs, rs6983267 and rsl447295) on chromosome 8q24 with the susceptibility of prostate cancer (PCs) in Beijing Han population. METHODS: Using a case-control design, 154 PCa patients and 138 cancer-free healthy subjects were included The distribution of allele and genotype frequencies of the SNPs rs6983267 and rsl447295 was detected with the polymerase chain reaction-high resolution melting curve (PCR-HRM) combined with gene sequencing,and analyzed the cumulative effect of risk genotypes of these two SNPs. RESULTS: AS for the genotypes of rs6983267,the distribution in the PCa group was as follow:33. 1% TT.46. 4% GT,20. 5% GG.as compared with 32. 6%,48. 5% and 18.9% in the healthy controls. As regards the genotypes of rsl447295, there were 3. 3% AA.38. 2% AC and 58. 6% CC in the PCa patients,in comparison with 1. 5% ,32.1% and 66. 4% in the controls. No significant difference was observed between these two SNPs and the risk of PCa(P>0. 05). And although results were not any statistically significant,men who carried one or two risk genotypes had a increased risk by 1. 231 times and 1. 571 times respectively,compared with men without any risk genotypes(P>0. 05). CONCLUSION: SNPs rs6983267 and rsl447295 on chromosome 8q24 might not be correlated with PCa in Beijing Han population.%目的:探讨染色体8q24两个单核苷酸多态性位点(SNPs) rs6983267和rs1447295,与北京地区前列腺癌(PCa)的相关性.方法:采用病例-对照研究,入选了154例PCa患者和138名正常对照者,检测2个SNPs在病例组和对照组间的等位基因及基因型的分布情况,并分析危险基因型的累积效应.结果:rs6983267有TT、GT及GG 3种基因型,在病例组的分布分别为33.1%、46.4%及20.5%,在对照组的分布分别为32.6%、48.5%及18.9%;rs1447295也有AA、AC及CC 3种基因型,在病例组的分布分别为3.3%、38.2%及58.6%,在

  11. Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795 and ACSL1 rs6552828

    Directory of Open Access Journals (Sweden)

    Noriyuki eFuku

    2015-05-01

    Full Text Available There are several gene variants that are candidates to influence functional capacity in long-lived individuals. As such, their potential association with exceptional longevity (EL, i.e., reaching 100+ years deserves analysis. Among them are rs7832552 in the thyrotropin-releasing hormone receptor (TRHR gene, rs1800795 in the interleukin-6 (IL6 gene and rs6552828 in the coenzyme A synthetase long-chain 1 (ACSL1 gene. To gain insight into their functionality (which is yet unknown, here we determined for the first time luciferase gene reporter activity at the muscle tissue level in rs7832552 and rs6552828. We then compared allele/genotype frequencies of the 3 abovementioned variants among centenarians [n=138, age range 100-111 years (114 women] and healthy controls [n=334, 20-50 years (141 women] of the same ethnic and geographic origin (Spain. We also studied healthy centenarians [n=79, 100-104 years (40 women] and controls [n=316, 27-81 years (156 women] from Italy, and centenarians [n=742, 100-116 years (623 women] and healthy controls [n=499, 23-59 years (356 women] from Japan. The THRH rs7832552 T-allele and ACSL1 rs6552828 A-allele up-regulated luciferase activity compared to the C and G-allele, respectively (P≤0.001. Yet we found no significant association of EL with rs7832552, rs1800795 or rs6552828 in any of the 3 cohorts. Further research is needed with larger cohorts of centenarians of different origin as well as with younger old people.

  12. COMPARISON OF TUNNELLING METHODS NATM AND ADECO-RS

    Directory of Open Access Journals (Sweden)

    Linda Černá Vydrová

    2015-04-01

    Full Text Available The New Austrian Tunnelling Method (NATM has been often used in the Czech Republic in last two decades. One of the methods, without application in the Czech Republic, is an Italian method called ADECO-RS, which has reached significant use in Italy and some other countries. It is the method of controlled deformation, which uses mainly the horizontal anchoring of the tunnel face to reinforce the area in front of the face (advance core. This technology is especially important in weak and soft rocks where is necessary to excavate quickly and smoothly with minimum disruption of initial stress state of the rock mass in the vicinity of the excavation. The use of NATM can be in some cases uneconomical and technically inadequately challenging and in such cases would be appropriate to choose another technology. Given the facts above, in the Czech environment there is no data available for comparison of these methods not only in terms of numerical modelling, but also in terms of feasibility and usability. The paper summarizes history of the tunnelling methods and it is closer devoted to NATM and ADECO-RS tunnelling approaches. The basic principles of both methods are set and further the comparison of these methods is made on a theoretical level. The paper hereinafter includes the analysis of fibreglass face anchors application during the construction of three-aisled Veleslavín Station and the impact assessment of tunnel face anchoring during the excavation of ventilation tunnel on the newly built part of the Prague Metro „V.A“. The paper also deals with practical knowledge gained during the technical visit of Italian Val di Sambro Tunnel which is built according to ADECO-RS approach. These findings are essential for the correct interpretation of Lunardi method.

  13. Hakusanamainonnan kehittäminen : Case- RS Finland

    OpenAIRE

    Vepsä, Tia

    2015-01-01

    Tämä opinnäytetyö on tehty yhteistyössä YEInternationalin kanssa, yrityksen RS- tuotemyynnin ja markkinoinnin osaston toimeksiantona. Tämä tutkimusprojekti on toteutettu hakukonemainonnan kehittämiseksi. Hakukone Googlella on olemassa mainostuspalvelu, jonka avulla yritys voi tuoda itsensä hakutuloksissa esille määritellyin mainoksin ja hakusanoin. AdWordsilla mainostamista pyritään kehittämään tehokkaammaksi Googlen tarjoamien aiempaa toimintaa raportoivien tilastotietojen avulla. Yrityksen ...

  14. PC interfacing using Centronics, RS232 and game ports

    CERN Document Server

    An, Pei

    1998-01-01

    The main links with your PC and the outside world are the centronic port, used for connecting the printer, the RS232 port, used for the mouse, and the games port for a joystick. This book explores how these input/output (I/O) ports can be put to use through a range of other interfacing applications. This is especially useful for laptop and palmtop PCs which cannot be fitted with internal I/O cards. A novel approach is taken by this book, combining the hardware through which the ports can be explored, and the software programming needed to carry out a range of experiments.Circuits are p

  15. RASSF1A and the rs2073498 Cancer Associated SNP

    OpenAIRE

    Donninger, Howard; Barnoud, Thibaut; Nelson, Nick; Kassler, Suzanna; CLARK, Jennifer; Cummins, Timothy D.; Powell, David W.; Nyante, Sarah; Millikan, Robert C.; Clark, Geoffrey J.

    2011-01-01

    RASSF1A is one of the most frequently inactivated tumor suppressors yet identified in human cancer. It is pro-apoptotic and appears to function as a scaffolding protein that interacts with a variety of other tumor suppressors to modulate their function. It can also complex with the Ras oncoprotein and may serve to integrate pro-growth and pro-death signaling pathways. A SNP has been identified that is present in approximately 29% of European populations [rs2073498, A(133)S]. Several studies h...

  16. Early determinants of attention and hyperactivity problems in adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil birth cohort study Determinantes precoces de problemas de atenção e hiperatividade na adolescência: a visita de 11 anos da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993

    Directory of Open Access Journals (Sweden)

    Luciana Anselmi

    2010-10-01

    Full Text Available The aim of this study was to assess early determinants of attention and hyperactivity problems in adolescents. In 1993, all hospital births in the city of Pelotas, Rio Grande do Sul State, Brazil, were monitored and mothers were interviewed (N = 5,249. At 11 years of age, 4,423 mothers answered the Strengths and Difficulties Questionnaire (SDQ in order to evaluate attention and hyperactivity problems in the adolescents. Crude and adjusted prevalence ratios were calculated using Poisson regression. Prevalence of attention and hyperactivity problems was 19.9%. Factors associated with the outcome in the adjusted analysis were: male gender, low family income, smoking during pregnancy, minor psychiatric disorders in the mother, and history of child's behavioral/emotional problems at four years of age. Early life events impacted attention and hyperactivity problems in adolescence. Risk factors for attention and hyperactivity problems found in this study were similar to those reported in other cultures.O objetivo deste trabalho foi estudar determinantes precoces dos problemas de atenção e hiperatividade em adolescentes. Em 1993, os nascimentos foram recrutados e as mães entrevistadas (n = 5.249. Aos 11 anos, 4.423 mães responderam ao Strengths and Difficulties Questionnaire (SDQ para avaliar problemas de atenção e hiperatividade nos adolescentes. Variáveis socioeconômicas, demográficas, biológicas e psicológicas foram investigadas como prováveis fatores de risco. Razões de prevalência brutas e ajustadas foram calculadas com regressão de Poisson. A prevalência de problemas de atenção e hiperatividade foi 19,9%. Sexo masculino, baixa renda familiar, tabagismo materno na gestação, transtornos psiquiátricos maternos e problemas de comportamento/emocionais do adolescente aos quatro anos permaneceram associados na análise ajustada. Eventos do início da vida influenciaram os problemas de atenção e hiperatividade na adolescência. Os

  17. No association between the SNPs (rs3749446 and rs1402000) in the PARL gene and LHON in Chinese patients with m.11778G>A.

    Science.gov (United States)

    Zhang, A-Mei; Jia, Xiaoyun; Zhang, Qingjiong; Yao, Yong-Gang

    2010-10-01

    According to a recent genome-wide linkage scan and association study of families with m.11778G>A in Thailand, two single nucleotide polymorphisms (SNPs) (rs3749446 and rs1402000) in the presenilins-associated rhomboid-like (PARL) gene were found to be associated with Leber hereditary optic neuropathy (LHON). In order to verify this association in Chinese LHON patients, we genotyped three PARL gene variants (rs3749446, rs953419, and rs1402000) in 179 patients with m.11778G>A and 170 patients with suspected LHON, and compared them to a control population containing the HapMap Chinese and 58 normal individuals analyzed in this study. We identified no association between these PARL gene SNPs and LHON in Chinese patients with m.11778G>A (P>0.05). Haplotype analysis also showed no statistical difference among the three Chinese populations.

  18. Association of the ADIPOQ Rs2241766 and Rs266729 Polymorphisms with Metabolic Syndrome in the Chinese Population:A Meta-analysis

    Institute of Scientific and Technical Information of China (English)

    ZHOU Jun Mei; ZHAO Yang; HU Dong Sheng; ZHANG Ming; WANG Shu; WANG Bing Yuan; HAN Cheng Yi; REN Yong Cheng; ZHANG Lu; ZHANG Hong Yan; YANG Xiang Yu

    2016-01-01

    Objective This meta-analysis was performed to summarize the association of the ADIPOQ rs2241766 and rs266729 polymorphisms with metabolic syndrome (MS) in the Chinese population. Methods We searched for articles in MEDLINE via PubMed, EMBASE, HuGE Navigator, CNKI, and Wanfang databases and calculated odds ratios (ORs) with 95% confidence intervals (CIs) to determine the strength of associations in fixed- or random-effects models. Results We included 21 articles in the meta-analysis: 17 reports of ADIPOQ rs2241766 with 3628 cases and 3000 controls and 8 of rs266729 with 2021 cases and 2226 controls. We found an increased risk of MS with the ADIPOQ rs2241766 polymorphism in some genetic models (allele model: OR=1.12, 95% CI:1.03-1.21; dominant model: OR=1.15, 95% CI: 1.04-1.28; homozygote model: OR=1.22, 95% CI:1.00-1.49) but no association with the ADIPOQ rs266729 polymorphism (allele model: OR=0.98, 95% CI:0.82-1.17; dominant model: OR=0.90, 95% CI: 0.79-1.02; recessive model: OR=1.09, 95% CI: 0.85-1.39;homozygote model: OR=1.03, 95% CI: 0.80-1.33). Conclusion The results of this meta-analysis suggest an association between the ADIPOQ rs2241766 polymorphism and MS in the Chinese population. G allele of ADIPOQ rs2241766 increases the risk of MS. Better designed studies with different ethnic populations and larger sample sizes are needed for assessing the relationship between ADIPOQ rs2241766 and rs266729 polymorphisms and MS in the future.

  19. The Design Of RS-232 and RS-485 level converter based on the “master-slave”type device%“主-从”式装置的RS-232和RS-485电平转换器设计

    Institute of Scientific and Technical Information of China (English)

    钱玲玲

    2015-01-01

    At present, due to a low energy consumption, easy data management and maintenance, and other advantages,a master-slave device is widely used in industrial control systems,however,because the interface is not compatible with the level of the PC RS232 interface and the RS485 bus of the micro-controller,it need level conversion in order to achieve network link between them.Based on this,this paper introduced a RS485 interface chip SN75LBC184, and designed a low-cost,、good application RS232 / RS485 converter.%目前,主从式装置因具有系统能耗低、易于数据管理与维护等优势,而被广泛应用在工业控制系统中,但也因PC机的RS232接口与单片机的RS485总线的接口电平不兼容,要实现两者通信网络的链接需要进行电平转换。基于此,本文引入了一种RS485接口芯片STC11F02E,并设计了一种低成本、可靠性强、应用性能好的RS232/RS485转换器。

  20. Moscas frugívoras e seus parasitoides nos municípios de Pelotas e Capão do Leão, Rio Grande do Sul, Brasil Frugivorous flies and their parasitoids in the cities of Pelotas and Capão do Leão, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Adrise Medeiros Nunes

    2012-01-01

    Full Text Available As moscas frugívoras (Tephritoidea são as principais pragas da fruticultura de clima temperado no Brasil. O objetivo do presente trabalho foi avaliar a infestação desses dípteros e a ocorrência de seus parasitoides em frutíferas nos municípios de Pelotas e Capão do Leão, localizados na região Sul, nas safras agrícolas de 2007/08 e 2008/09. Foram coletados frutos de araçazeiro-amarelo e vermelho (Psidium cattleianum Sabine, 1821, butiazeiro [Butia capitata (Mart. Becc., 1916], caquizeiro (Diospyros kaki Linnaeus, 1753, cerejeira-do-mato (Eugenia involucrata DC., 1828, goiabeira [Psidium guajava (Linnaeus, 1753], goiabeira-serrana [Acca sellowiana (Berg. Burret, 1941], nespereira [Eriobotrya japonica (Thunb. Lindley, 1822], pessegueiro [Prunus persicae (L. Batsch, 1801], pitangueira (Eugenia uniflora Linnaeus,1753 e uvalheira (Eugenia pyriformis Cambessèdes, 1832. Os frutos foram coletados e transportados para o laboratório, onde foram individualizados e determinados os seguintes parâmetros: índice de infestação das moscas, índice de parasitismo e frequência de indivíduos por espécie de parasitoide. Foram constatadas duas espécies de Tephritidae, Anastrepha fraterculus (Wiedemann, 1830 (90,5% e Ceratitis capitata (Wiedemann, 1824 (9,5% e duas de Lonchaeidae, Neosilba zadolicha McAlpine & Steyskal, 1982 (87,8% e uma espécie ainda não descrita, referida como Neosilba n. sp. 3 (12,2%. Anastrepha fraterculus é a espécie mais abundante nos dois municípios, sendo constatada na maioria das frutíferas coletadas. Caquizeiro e goiabeira foram os hospedeiros que apresentaram o maior índice de infestação por C. capitata. Quanto às espécies de Neosilba, a maior infestação ocorreu em frutos de goiabeira-serrana. Dos parasitoides emergidos, foram identificadas três espécies, sendo duas de Braconidae, Doryctobracon areolatus (Szépligeti, 1911 (52,6% e Opius bellus (Gahan, 1930 (27,5% e uma espécie de Figitidae, Aganaspis

  1. Effects of APOE rs429358, rs7412 and GSTM1/GSTT1 Polymorphism on Plasma and Erythrocyte Antioxidant Parameters and Cognition in Old Chinese Adults

    Directory of Open Access Journals (Sweden)

    Linhong Yuan

    2015-09-01

    Full Text Available Apolipoprotein E (APOE and oxidative damage were correlated with the risk of Alzheimer’s disease (AD. Glutathione S-transferase (GST polymorphism was proved to be associated with body antioxidant capacity and involved in the oxidative damage related chronic diseases. To explore the combined effects of APOE rs429358, rs7412 and GSTM1/T1 polymorphism on antioxidant parameters and cognition in old Chinese adults, a community-based cross-sectional study was carried out in 477 Chinese adults aged from 55 to 75. Information on demography and lifestyle of the participants was collected with a questionnaire. Cognitive function was measured by using a Montreal Cognitive Assessment (MoCA test. Fasting venous blood samples were collected for APOE rs429358, rs7412 and GSTM1/T1 genotyping, and parameter measurement. No association of APOE rs7412, rs429358 and GSTM1/T1 polymorphisms with cognition was detected in the old Chinese adults. APOE rs429358, rs7412 polymorphism was mainly associated with plasma α-tocopherol, low density lipoprotein cholesterol (LDL-C and plasma total antioxidant capacity (T-AOC levels (p < 0.05. Interaction of APOE rs429358 and GSTT1 genotype on the plasma triglyceride (TG level and erythrocyte catalase (CAT and GST enzyme activities were detected (p < 0.05. The subjects with APOE rs429358 T/C + C/C and GSTT1− genotype were found to have the highest plasma TG level, erythrocyte CAT enzyme activity, and the lowest GST enzyme activity compared to subjects with other genotypes (p < 0.05. Lowest erythrocyte CAT enzyme activity and highest glutathione peroxidase (GSH-Px enzyme activity were detected in the subjects with APOE rs7412 T/C + T/T and GSTM1+ genotype as compared with subjects with other genotypes. The levels of plasma and erythrocyte antioxidant parameters were APOE genotype associated. GSTM1 or GSTT1 genotype modified the influence of APOE rs7412, rs429358 polymorphism on antioxidant parameters.

  2. Functional analysis of deep intronic SNP rs13438494 in intron 24 of PCLO gene.

    Directory of Open Access Journals (Sweden)

    Seunghee Seo

    Full Text Available The single nucleotide polymorphism (SNP rs13438494 in intron 24 of PCLO was significantly associated with bipolar disorder in a meta-analysis of genome-wide association studies. In this study, we performed functional minigene analysis and bioinformatics prediction of splicing regulatory sequences to characterize the deep intronic SNP rs13438494. We constructed minigenes with A and C alleles containing exon 24, intron 24, and exon 25 of PCLO to assess the genetic effect of rs13438494 on splicing. We found that the C allele of rs13438494 reduces the splicing efficiency of the PCLO minigene. In addition, prediction analysis of enhancer/silencer motifs using the Human Splice Finder web tool indicated that rs13438494 induces the abrogation or creation of such binding sites. Our results indicate that rs13438494 alters splicing efficiency by creating or disrupting a splicing motif, which functions by binding of splicing regulatory proteins, and may ultimately result in bipolar disorder in affected people.

  3. Photospheric imaging of the RS CVn system HR 1099

    Science.gov (United States)

    Donati, J.-F.; Brown, S. F.; Semel, M.; Rees, D. E.; Dempsey, R. C.; Matthews, J. M.; Henry, G. W.; Hall, D. S.

    1992-01-01

    Spectropolarimetric, spectroscopic, and photometric observations of the RS CVn binary system HR 1099 = V711 Tau (K1IV+G5V) were made from Oct. 1988 to Jan. 1991. From Doppler imaging of the unpolarized spectra and the corresponding data, two maximum entropy images of the temperature distribution of the active K1 subgiant at epochs 1988.9 and 1990.9 were derived. Zeeman-Doppler imaging of the circularly polarized spectra has led to the first magnetic maps of a star other than the sun. The fragmentary observations made at epoch 1989.6 suggest that the star's magnetic field lines were emerging radially and/or poloidally from an equatorial warm region at that time, quite likely one of these reconstructed in the 1988.9 temperature image.

  4. Depth Control for AUV Based on RS-LSSVM

    Institute of Scientific and Technical Information of China (English)

    宋晓茹; 宋保维; 雷志勇; 梁庆卫

    2012-01-01

    Aimed at uncertainties and model' s impreciseness, nonlinearity and time-variability of depth control system in autonomous underwater vehicle ( AUV), a depth predictive control method was put forward based on rough set (RS) and least squares support vector machine (LSSVM). By using RS theory, the monitor data attribute of AUV was reduced to eliminate the redundant information and to improve efficiency. Then, LSSVM model was trained by using the reduced rules, and its parameters were optimized by using chaos theory for the higher accurate control. Taken an AUV typed NPS Phoenix as an example, its depth step response, horizontal rudder and pitch change were simulated. The simulation results show that the method improves the model' s accuracy and has better real-time response, fault-tolerant ability, reliability and strong anti-interfere capability.

  5. 0-3 års pædagogik

    DEFF Research Database (Denmark)

    Broström professor m.so., Stig

    2013-01-01

    Institutioner og pasningstilbud til de 0-3 årige har eksisteret gennem en lang årrække. Danmark en relativ høj dækningsgrad sammenlignet med andre lande. Tilbuddene er primært vuggestuer, integrerede institutioner og dagpleje. Der er de senere år kommet mere politisk og forskningsmæssigt fokus på...... områdets betydning i takt med, at forskningen har understreget den enorme betydning 0-3 års alderen har for børn og unges senere succes i livet. Men hvad pædagogikken rent faktisk består af i disse institutionelle rammer er desværre forskningsmæssigt underbelyst. I denne kvalitative analyse beskrives kort...

  6. NETWORK INTRUSION DETECTION METHOD BASED ON RS-MSVM

    Institute of Scientific and Technical Information of China (English)

    Xiao Yun; Han Chongzhao; Zheng Qinghua; Zhang Junjie

    2006-01-01

    A new method called RS-MSVM (Rough Set and Multi-class Support Vector Machine) is proposed for network intrusion detection. This method is based on rough set followed by MSVM for attribute reduction and classification respectively. The number of attributes of the network data used in this paper is reduced from 41 to 30 using rough set theory. The kernel function of HVDM-RBF (Heterogeneous Value Difference Metric Radial Basis Function), based on the heterogeneous value difference metric of heterogeneous datasets, is constructed for the heterogeneous network data. HVDM-RBF and one-against-one method are applied to build MSVM. DARPA (Defense Advanced Research Projects Agency) intrusion detection evaluating data were used in the experiment. The testing results show that our method outperforms other methods mentioned in this paper on six aspects: detection accuracy, number of support vectors, false positive rate, false negative rate, training time and testing time.

  7. Association of the Three Common SNPs of Cyclooxygenase-2 Gene (rs20417, rs689466, and rs5275 with the Susceptibility of Breast Cancer: An Updated Meta-Analysis Involving 34,590 Subjects

    Directory of Open Access Journals (Sweden)

    Zhi-Jun Dai

    2014-01-01

    Full Text Available Several single nucleotide polymorphisms have been identified in cyclooxygenase-2 (COX-2 genes (e.g., −765 G>C (rs20417, −1195G>A (rs689466, and 8473 C>T (rs5275. The association of these SNPs with the risk of different cancer types is still controversial. This study aims to evaluate the correlation between these SNPs and breast cancer risk in different ethnic groups. We have searched PubMed, Web of Knowledge, and Embase for relevant studies. Odds ratios (ORs with 95% confidence intervals (CIs were used to estimate the strength of the associations. A total of 13 studies (15,330 cases and 19,260 controls were eligible for meta-analysis. This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians. The rs5275 polymorphism had no association with breast cancer risk.

  8. Processing of PLA/RS and PLA/Kenaf pellets into composite panels

    OpenAIRE

    Dimeski, Dimko

    2006-01-01

    In this material the research is focused on preparation and characterization of PLA/RS and PLA/Kenaf cost – effective polymer composites as constructive materials for houses and offices. The technological procedure for production of PLA/RS and PLA /kenaf fiber composites was determined. Kenaf / PLA and PLA/RS preforms were molded by thermo compression in a closed mold. Various kinds of preforms with different thickness, specific weight and fiber / matrix ratios were molded. Th...

  9. Creative Implementation of 3Rs Principles within Industry Programs: Beyond Regulations and Guidelines

    OpenAIRE

    Bratcher, Natalie A; Reinhard, Gregory R

    2015-01-01

    The industry involved with using animals as an essential part of research has supported the theory and philosophy of the 3Rs for years. However, both the culture and approach surrounding the 3Rs is evolving rapidly, and many institutions are attempting to surpass the regulations and guidelines to implement the 3Rs for improved science and animal welfare. Regulatory documents and guidelines such as the Animal Welfare Act, the Guide for the Care and Use of Laboratory Animals, the Public Health ...

  10. Construction of REDD monitoring system using GIS and RS techniques

    Directory of Open Access Journals (Sweden)

    Jungsoo Lee

    2012-06-01

    Full Text Available This study aimed to construct a MRV system for the REDD regions. The system was based on the GIS and Remote Sensing techniques, and it developed a method which could detect the land cover change area as well as evaluate its accuracy. GIS, the Remote Sensing technique and the statistical modelling technique were merged, and then we monitored areas of deforestation among the REDD regions. This study compared deforestation from administrative information (GIS deforestation1 with deforestation (RS deforestation extracted from satellite imagery by vegetation indices (NDVI, NBR, NDWI. The highest extraction accuracy that applies filtering to NDVI with a threshold of 1.5 showed reliable accuracy 35.47% with a k‐value of 0.20. However, one of the reasons for the accuracy error was due to the difference between land‐use change and land‐cover change. The actual rate of land‐cover change deforestation was 32% on the administrative information. The other reason was a 7.52% error extraction of the forest management area. Finally, considering the deforestation of the changed land‐cover region (GIS deforestation2 and RS deforestation, the highest accuracy was observed at the NDVI threshold value interval of 2 and showed an extraction rate and index of 61.2% and 0.23, respectively. In comparison with the case of applying GIS deforestation I, it showed 36.7% and 0.03 improvements. The MRV monitoring system based on the GIS and Remote Sensing techniques would enable the monitoring of larger size areas regularly and with high reliability.

  11. XPG rs2296147 T>C polymorphism predicted clinical outcome in colorectal cancer.

    Science.gov (United States)

    Wang, Fang; Zhang, Shao-Dan; Xu, Hong-Mei; Zhu, Jin-Hong; Hua, Rui-Xi; Xue, Wen-Qiong; Li, Xi-Zhao; Wang, Tong-Min; He, Jing; Jia, Wei-Hua

    2016-03-01

    Xeroderma pigmentosum group G (XPG), one of key components of nucleotide excision repair pathway (NER), is involved in excision repair of UV-induced DNA damage. Single nucleotide polymorphisms (SNPs) in the XPG gene have been reported to associate with the clinical outcome of various cancer patients. We aimed to assess the impact of four potentially functional SNPs (rs2094258 C>T, rs2296147 T>C, rs751402 G>A, and rs873601 G>A) in the XPG gene on prognosis in colorectal cancer (CRC) patients. A total of 1901 patients diagnosed with pathologically confirmed CRC were genotyped for four XPG polymorphisms. Cox proportional hazards model analysis controlled for several confounding factors was conducted to compute hazard ratios (HRs) and 95% confidence intervals (CIs). Of the four included SNPs, only rs2296147 was shown to significantly affect progression-free survival (PFS) in CRC. Patients carrying rs2296147 CT/TT genotype had a significantly shorter median 10 years PFS than those carrying CC genotype (88.5 months vs. 118.1 months), and an increased progression risk were observed with rs2296147 (HR = 1.324, 95% CI = 1.046-1.667). Moreover, none of the four SNPs were associated with overall survival. In conclusion, our study showed that XPG rs2296147 CT/TT variants conferred significant survival disadvantage in CRC patients in term of PFS. XPG rs2296147 polymorphism could be predictive of unfavorable prognosis of CRC patients. PMID:26887052

  12. Validation of the Official Slovak Version of the Unified Dyskinesia Rating Scale (UDysRS)

    OpenAIRE

    Matej Skorvanek; Michal Minar; Milan Grofik; Katarina Kracunova; Vladimir Han; Frantisek Cibulcik; Jan Necpal; Ladislav Gurcik; Peter Valkovic

    2015-01-01

    After successful clinimetric testing of the Unified Dyskinesia Rating Scale (UDysRS), a program for translation and validation of non-English versions of the UDysRS was initiated. The aim of this study was to validate and confirm the factor structure of the Slovak translation of the UDysRS. We examined 251 patients with Parkinson’s disease and dyskinesia using the Slovak version of the UDysRS. The average age of our sample was 65.2 ± 9.2 years and average disease duration was 10.9 ± 5.0 years...

  13. Prevenção de defeitos do tubo neural: prevalência do uso da suplementação de ácido fólico e fatores associados em gestantes na cidade de Pelotas, Rio Grande do Sul, Brasil Prevention of neural tube defects: prevalence of folic acid supplementation during pregnancy and associated factors in Pelotas, Rio Grande do Sul State, Brazil

    Directory of Open Access Journals (Sweden)

    Cíntia Leal Sclowitz Mezzomo

    2007-11-01

    Full Text Available Com o objetivo de determinar a prevalência do uso do ácido fólico e fatores associados na gestação e no período periconcepcional, realizou-se um estudo transversal de base populacional nas cinco maternidades da cidade de Pelotas, Rio Grande do Sul, Brasil. A coleta de dados ocorreu no período de 1º de abril a 15 de agosto de 2006, com 1.450 mulheres. As entrevistas foram realizadas em nível hospitalar por questionário padronizado. A análise estatística se realizou por regressão de Poisson. A prevalência do uso de ácido fólico na gestação foi de 31,8%, e no período periconcepcional, foi de 4,3%. Os fatores associados ao uso de ácido fólico foram: cor branca, escolaridade acima de nove anos, renda acima de 600 Reais, idade acima de trinta anos, gestação planejada, sete ou mais consultas de pré-natal, consultas na rede privada de saúde e conhecimento sobre o ácido fólico. Para diminuir a prevalência de defeitos do tubo neural, é importante promover-se o uso do ácido fólico nas mulheres em idade fértil, nas mulheres sócio-economicamente menos favorecidas e torná-lo disponível na rede pública de saúde.To determine folic acid use and associated factors, a cross-sectional population-based study was conducted in all five maternity hospitals in Pelotas, Rio Grande do Sul State, Brazil. Data were collected from April 1 to August 15, 2006 (n = 1,450 women. A standard questionnaire was applied in the hospitals. Statistical analysis used Poisson regression. Prevalence of folic acid consumption during pregnancy was 31.8%, and periconceptional use was 4.3%. The following were associated with folic acid use: white skin color, schooling > 9 years, family income > R$600, age > 30 years, planned pregnancy, > 7 prenatal visits, knowledge on folic acid, and prenatal care in the private health system. In order to prevent neural tube defects, it is important to promote folic acid use among childbearing-age women and to supply folic

  14. A Combination of CD28 (rs1980422 and IRF5 (rs10488631 Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study.

    Directory of Open Access Journals (Sweden)

    Lucia Vernerova

    Full Text Available The aim of the study was to analyse genetic architecture of RA by utilizing multiparametric statistical methods such as linear discriminant analysis (LDA and redundancy analysis (RDA.A total of 1393 volunteers, 499 patients with RA and 894 healthy controls were included in the study. The presence of shared epitope (SE in HLA-DRB1 and 11 SNPs (PTPN22 C/T (rs2476601, STAT4 G/T (rs7574865, CTLA4 A/G (rs3087243, TRAF1/C5 A/G (rs3761847, IRF5 T/C (rs10488631, TNFAIP3 C/T (rs5029937, AFF3 A/T (rs11676922, PADI4 C/T (rs2240340, CD28 T/C (rs1980422, CSK G/A (rs34933034 and FCGR3A A/C (rs396991, rheumatoid factor (RF, anti-citrullinated protein antibodies (ACPA and clinical status was analysed using the LDA and RDA.HLA-DRB1, PTPN22, STAT4, IRF5 and PADI4 significantly discriminated between RA patients and healthy controls in LDA. The correlation between RA diagnosis and the explanatory variables in the model was 0.328 (Trace = 0.107; F = 13.715; P = 0.0002. The risk variants of IRF5 and CD28 genes were found to be common determinants for seropositivity in RDA, while positivity of RF alone was associated with the CTLA4 risk variant in heterozygous form. The correlation between serologic status and genetic determinants on the 1st ordinal axis was 0.468, and 0.145 on the 2nd one (Trace = 0.179; F = 6.135; P = 0.001. The risk alleles in AFF3 gene together with the presence of ACPA were associated with higher clinical severity of RA.The association among multiple risk variants related to T cell receptor signalling with seropositivity may play an important role in distinct clinical phenotypes of RA. Our study demonstrates that multiparametric analyses represent a powerful tool for investigation of mutual relationships of potential risk factors in complex diseases such as RA.

  15. Association between rs7517847 and rs2201841 polymorphisms in IL-23 receptor gene and risk of ankylosing spondylitis: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Bin Xu

    2015-04-01

    Full Text Available To comprehensively evaluate the association between rs7517847 and rs2201841 polymorphisms in the Interleukin-23 (IL-23 receptor gene and ankylosing spondylitis (AS, a meta-analysis was performed. The Pubmed, Embase, MEDLINE, Cochrane, China National Knowledge Infrastructure (CNKI, VIP, Wanfang and China Biology Medicine disc (CBMdisc databases were searched to identify eligible studies on rs7517847 and rs2201841 polymorphisms in the IL-23 receptor gene and AS that were published through September 2014. Data of interest were extracted from each study, and the meta-analysis was performed using STATA 12.0. Four studies were eligible for the meta-analysis and included a total patient population of 2,465. With regards to rs7517847, the current study showed that the genotype GG and allele G might play a protective role during AS (OR = 0.76, 95% CI [0.59–0.99]; OR = 0.88, 95% CI [0.78–0.99] for homozygote and allelic models, respectively. However, according to the meta-analysis, there was no statistical association between the genotype or allele of rs2201841 and an individual’s susceptibility to AS in all genetic models. In conclusion, it was the IL-23 rs7517847 polymorphism rather than the rs2201841 polymorphism that had a statistical association with AS. Nevertheless, more evidence is needed to confirm this result. Consequently, it is necessary to carry out more high-quality studies to confirm the associations between these two single nucleotide polymorphisms and AS.

  16. Lack of association of two common polymorphisms rs2910164 and rs11614913 with susceptibility to hepatocellular carcinoma: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Zhongxia Wang

    Full Text Available BACKGROUND: Single nucleotide polymorphisms (SNPs in microRNA-coding genes may participate in the process of carcinogenesis by altering the expression of tumor-related microRNAs. It has been suggested that two common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to hepatocellular carcinoma (HCC. However, published results are inconsistent and inconclusive. In the present study, we performed a meta-analysis to systematically summarize the possible association between the two SNPs and the risk for HCC. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a search of case-control studies on the associations of SNPs rs2910164 and/or rs11614913 with susceptibility to HCC in PubMed, EMBASE, ISI Web of Science, Cochrane Central Register of Controlled Trials, ScienceDirect, Wiley Online Library and Chinese National Knowledge Infrastructure databases. Data from eligible studies were extracted for meta-analysis. HCC risk associated with the two polymorphisms was estimated by pooled odds ratios (ORs and 95% confidence intervals (95% CIs. 5 studies on rs2910164 and 4 studies on rs11614913 were included in our meta-analysis. Our results showed that neither allele frequency nor genotype distribution of the two polymorphisms was associated with risk for HCC in all genetic models. Similarly, subgroup analysis in Chinese population showed no association between the two SNPs and the susceptibility to HCC. CONCLUSIONS/SIGNIFICANCE: This meta-analysis suggests that two common SNPs rs2910164 and rs11614913 are not associated with the risk of HCC. Well-designed studies with larger sample size and more ethnic groups are required to further validate the results.

  17. NEDD4 single nucleotide polymorphism rs2271289 is associated with keloids in Chinese Han population.

    Science.gov (United States)

    Zhao, Ying; Liu, Sheng-Li; Xie, Jian; Ding, Mao-Qian; Lu, Meng-Zhu; Zhang, Lan-Fang; Yao, Xiu-Hua; Hu, Bai; Lu, Wen-Sheng; Zheng, Xiao-Dong

    2016-01-01

    Keloids are abnormally raised fibroproliferative lesions that usually occur following cutaneous traumas. Recently, a large-scale genome-wide association study (GWAS) has identified multiple single nucleotide polymorphisms (SNPs) in three genetic loci that are associated with keloids in Japanese population. Subsequently, two reported loci 1q41 (rs873549 and rs1442440) and 15q21.3 (rs2271289) for keloids were confirmed in selected Chinese population. The association of these SNPs with clinical features of keloids, has not yet been studied. To explore the role of these SNPs in the pathogenesis of keloids, we performed a case-controlled study in another independent Chinese Han population to analyze the correlation between 4 SNPs (rs873549, rs2118610, rs1511412, rs2271289) and keloids phenotypes. 309 keloids patients and 1080 control subjects were included. The results showed that, in the dominant mode of inheritance, the minor allele T of SNP rs2271289 had significantly higher odd ratios (ORs) in the severe keloid group compared with both the controls and the mild keloid group. The ORs were maintained after Bonferroni's correction (OR: 4.09, 95% CI: 1.78-9.37, P-value 3.25E-04). The ratio of the severe: mild OR for rs2271289 (dominant model) is (4.73/1.84=2.57). Similar associations in SNP rs2271289 were seen for groups with no family history and multiplesite compared with the control groups. No associations between keloid number, family history or severity relative to the controls were observed for the other three SNPs. Our data support that rs2271289 is strongly associated with severe keloids and might contribute to the complexity of clinical features of keloids. PMID:27158346

  18. Study of association between polymorphisms in the PSMB5 (rs11543947 and PSMA3 (rs2348071 genes and multiple sclerosis in Latvians

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    Kalnina J.

    2014-07-01

    Full Text Available Functional realization of many signalling proteins and transcription factors implicated in the development and progression of multiple sclerosis is mediated by proteasomes. Aim of this case-control study was to evaluate genetic variations in the PSMB5 and PSMA3 genes encoding proteasomal subunits on the susceptibility to multiple sclerosis in Latvians. Methods. The rs11543947 (PSMB5 and rs2348071 (PSMA3 loci were genotyped in 291 multiple sclerosis patients and 305 healthy individuals and analysed general, subtype and sex-specific associations with the disease. Results. Loci rs11543947 and rs2348071 were identified as disease neutral and susceptible respectively. The rs2348071 heterozygous genotype GA showed strong main effect (P < 0.001; OR = 1.891, 95 % CI [1.360–2.628], and moderate (P < 0.01; OR = 1.663, 95 % CI [1.152– 2.402] and strong (P < 0.001; OR = 2.459, 95 % CI [1.534–3.943] association with relapsing-remitting and secondary progressive phases of disease respectively. No genotype-sex interaction associated with multiple sclerosis has been detected. Conclusions. Our results suggest susceptibility of the rs2348071 heterozygous genotype to multiple sclerosis in Latvians.

  19. DSP network control system based on RS485%基于RS485总线的DSP网络控制系统设计

    Institute of Scientific and Technical Information of China (English)

    沈文杰; 陈文清; 陈伟

    2011-01-01

    To make reliable communication between multiple industrial production data in a computer control system, and to achieve real time control, the RS485 network control system is proposed in this paper based on TMS320LF2407A. The design of DSP network control system is introduced. The hardware of field control note was designed using RS485 bus, and the detailed software implementation is described. The RS485 reliable dato communications is achieved between the PC and the bottom of the controller's. It verified their network control targets through the production site.%为了使工业生产计算机控制系统中多种数据之间有可靠通讯,满足过程实时控制的要求,提出了一种基于DSP的网络控制系统的设计方案,介绍了DSP网络控制系统的总体设计思路,运用RS485总线技术对现场控制节点进行硬件设计并对RS485通讯软件的实现进行了详细地分析,实现了上位机与底层控制器之间的RS485数据的可靠通讯,通过生产现场调试验证了网络控制指标.

  20. Uso de métodos anticoncepcionais e adequação de contraceptivos hormonais orais na cidade de Pelotas, Rio Grande do Sul, Brasil: 1992 e 1999

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    Juvenal Soares Dias-da-Costa

    2002-02-01

    Full Text Available Realizou-se um estudo transversal de base populacional, com o objetivo de verificar a utilização de métodos contraceptivos e adequação do emprego de anticoncepcionais orais pelas mulheres de 20 a 49 anos, residentes na zona urbana da cidade de Pelotas. Os resultados foram comparados com outro estudo transversal de base populacional, realizado em 1992. Utilizou-se amostragem por conglomerados, incluindo-se 766 mulheres com idade entre 20 e 49 anos. Do total de mulheres, 495 (64,6% utilizavam algum método contraceptivo, sendo mais freqüentemente empregados: anticoncepcionais orais (55,4%, ligadura tubária (22,2%, preservativo (10,5% e dispositivo intra-uterino (7,7%. Entre as usuárias de anticoncepcionais orais, verificou-se que 22,2% apresentavam contra-indicação para seu emprego. O uso incorreto associou-se significativamente à idade, mas foi semelhante entre as classes sociais. Comparando os resultados com aqueles do estudo anterior, destaca-se a redução no emprego de anticoncepcionais orais, e maior freqüência de ligaduras, uso de preservativos e dispositivos intra-uterinos.

  1. Excesso de peso/obesidade no ciclo da vida e composição corporal na idade adulta: coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1982

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    Gabriela Callo

    2016-01-01

    Full Text Available Resumo: O presente estudo teve por objetivo avaliar a associação entre sobrepeso/obesidade em diferentes momentos do ciclo vital com a composição corporal em adultos jovens. Foram utilizados dados da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1982, que tem acompanhado, em diferentes idades, os nascidos vivos cuja família residia na zona urbana da cidade. Aos 30 anos, 3.701 participantes da coorte foram entrevistados, e a composição corporal foi avaliada usando-se o Bod Pod, 2.219 membros da coorte apresentavam, pelo menos, uma medida de peso e altura nos três períodos (infância, adolescência e vida adulta, 24% nunca apresentaram sobrepeso, e 68,6% nunca foram considerados como sendo obesos. Os maiores valores de índice de massa corporal (IMC e de percentual de massa gorda aos 30 anos foram observados naqueles que foram considerados como tendo sobrepeso nos três períodos ou na adolescência e na idade adulta, enquanto que aqueles com sobrepeso/obesidade apenas na infância ou na adolescência tiveram médias de IMC e percentual de massa gorda similares daqueles que nunca apresentaram sobrepeso/obesidade. Os resultados indicam o benefício da interrupção precoce do sobrepeso/obesidade.

  2. Can mothers rely on the Brazilian health system for their deliveries? An assessment of use of the public system and out-of-pocket expenditure in the 2004 Pelotas Birth Cohort Study, Brazil

    Directory of Open Access Journals (Sweden)

    Bertoldi Andréa D

    2008-03-01

    Full Text Available Abstract Background In a country where comprehensive free health care is provided via a public health system (SUS, an unexpected high frequency of catastrophic out-of-pocket expenditure has been described. We studied how deliveries were financed among mothers of a birth cohort and whether they were an important source of household out-of-pocket expenditure. Methods All deliveries occurring in the city of Pelotas, Brazil, during 2004, were recruited for a birth cohort study. All mothers were interviewed just after birth and three months later. Comprehensive data on the pregnancy, delivery, birth conditions and newborn health were collected, along with detailed information on expenses related to the delivery. Results The majority of the deliveries (81% were financed by the public health system, a proportion that increased to more than 95% among the 40% poorest mothers. Less than 1% of these mothers reported some out-of-pocket expenditure. Even among those mothers covered by a private health plan, nearly 50% of births were financed by the SUS. Among the 20% richest, a third of the deliveries were paid by the SUS, 50% by private health plans and 17% by direct payment. Conclusion The public health system offered services in quantity and quality enough to attract even beneficiaries of private health plans and spared mothers from the poorest strata of the population of practically any expense.

  3. História e educação: as relações de gênero em Pelotas no final do século 19 e início do século 20

    Directory of Open Access Journals (Sweden)

    Eliane Teresinha Peres

    2012-07-01

    Full Text Available  Entendendo gênero como elemento constitutivo das relações sociais, a partir da contribuição de Joan Scott, tomo aqui as relações entre homens e mulheres no espaço urbano pelotense no final do século 19 e início do século 20 como foco de análise. Com um corpus de dados empíricos, obtidos em jornais, almanaques, revistas, relatórios do período de estudo, analiso as práticas sociais e culturais de homens e mulheres articulado com suas posições de classe e grupo étnico.Palavras-chave: história, educação, relações de gênero.   Abstract Understanding gender as constitutive element of social relationships, from Joan Scott's contribution, I take here men and women relationships in the urban space of Pelotas in the end of the 19 century and beginning of the 20 century as focus of analysis. With a corpus of empirical data, got in newspapers, almanacs, magazines, reports, of the period in study, I analyze social and cultural practices of men and women articulated with their class position and ethnic group. Keywords: history, education, gender relations.   

  4. Variation in the group B Streptococcus CsrRS regulon and effects on pathogenicity

    NARCIS (Netherlands)

    Jiang, Sheng-Mei; Ishmael, Nadeeza; Hotopp, Julie Dunning; Puliti, Manuela; Tissi, Luciana; Kumar, Nikhil; Cieslewicz, Michael J.; Tettelin, Herve; Wesselsl, Michael R.

    2008-01-01

    CsrRS (or CovRS) is a two-component regulatory system that controls expression of multiple virulence factors in the important human pathogen group B Streptococcus (GBS). We now report global gene expression studies in GBS strains 2603V/R and 515 and their isogenic csrR and csrS mutants. Together wit

  5. On Best Approximations from RS-sets in Complex Banach Spaces

    Institute of Scientific and Technical Information of China (English)

    Chong LI

    2005-01-01

    The concept of an RS-set in a complex Banach Space is introduced and the problem of best approximation from an RS-set in a complex space is investigated. Results consisting of characterizations, uniqueness and strong uniqueness are established.

  6. The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing

    NARCIS (Netherlands)

    Pharoah, P.D.; Palmieri, R.T.; Ramus, S.J.; Gayther, S.A.; Andrulis, I.L.; Anton-Culver, H.; Antonenkova, N.; Antoniou, A.C.; Goldgar, D.; Beattie, M.S.; Beckmann, M.W.; Birrer, M.J.; Bogdanova, N.; Bolton, K.L.; Brewster, W.; Brooks-Wilson, A.; Brown, R.; Butzow, R.; Caldes, T.; Caligo, M.A.; Campbell, I.; Chang-Claude, J.; Chen, Y.A.; Cook, L.S.; Couch, F.J.; Cramer, D.W; Cunningham, J.M.; Despierre, E.; Doherty, J.A.; Dork, T.; Durst, M.; Eccles, D.M.; Ekici, A.B.; Easton, D.; Fasching, P.A.; Fazio, A. de; Fenstermacher, D.A.; Flanagan, J.M.; Fridley, B.L.; Friedman, E.; Gao, B.; Sinilnikova, O.; Gentry-Maharaj, A.; Godwin, A.K.; Goode, E.L.; Goodman, M.T.; Gross, J.; Hansen, T.V.; Harnett, P.; Rookus, M.; Heikkinen, T.; Hein, R.; Hogdall, C.; Hogdall, E.; Iversen, E.S.; Jakubowska, A.; Johnatty, S.E.; Karlan, B.Y.; Kauff, N.D.; Kaye, S.B.; Chenevix-Trench, G.; Kelemen, L.E.; Kiemeney, L.A.L.M.; Kjaer, S.K.; Lambrechts, D.; Lapolla, J.P.; Lazaro, C.; Le, N.D.; Leminen, A.; Leunen, K.; Levine, D.A.; Lu, Y.; Lundvall, L.; MacGregor, S.; Marees, T.; Massuger, L.F.A.G.; McLaughlin, J.R.; Menon, U.; Montagna, M.; Moysich, K.B.; Narod, S.A.; Nathanson, K.L.; Nedergaard, L.; Ness, R.B.; Nevanlinna, H.; Nickels, S.; Osorio, A.; Paul, J.; Pearce, C.L.; Phelan, C.M.; Pike, M.C.; Radice, P.; Rossing, M.A.; Schildkraut, J.M.; Sellers, T.A.; Singer, C.F.; Song, H.; Stram, D.O.; Sutphen, R.; Lindblom, A.

    2011-01-01

    PURPOSE: An assay for the single-nucleotide polymorphism (SNP), rs61764370, has recently been commercially marketed as a clinical test to aid ovarian cancer risk evaluation in women with family histories of the disease. rs67164370 is in a 3'-UTR miRNA binding site of the KRAS oncogene and is a candi

  7. The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing

    DEFF Research Database (Denmark)

    Pharoah, Paul D P; Palmieri, Rachel T; Ramus, Susan J;

    2011-01-01

    PURPOSE: An assay for the single nucleotide polymorphism (SNP) rs61764370 has recently been commercially marketed as a clinical test to aid ovarian cancer risk evaluation in women with family histories of the disease. rs67164370 is in a 3'UTR miRNA binding site of the KRAS oncogene, and is a cand...

  8. Genetic Variant rs10757278 on Chromosome 9p21 Contributes to Myocardial Infarction Susceptibility

    Directory of Open Access Journals (Sweden)

    Guangyuan Chen

    2015-05-01

    Full Text Available Large-scale genome-wide association studies (GWAS have revealed that rs10757278 polymorphism (or its proxy rs1333049 on chromosome 9p21 is associated with myocardial infarction (MI susceptibility in individuals of Caucasian ancestry. Following studies in other populations investigated this association. However, some of these studies reported weak or no significant association. Here, we reevaluated this association using large-scale samples by searching PubMed and Google Scholar databases. Our results showed significant association between rs10757278 polymorphism and MI with p = 6.09 × 10−22, odds ratio (OR = 1.29, 95% confidence interval (CI 1.22–1.36 in pooled population. We further performed a subgroup analysis, and found significant association between rs10757278 polymorphism and MI in Asian and Caucasian populations. We identified that the association between rs10757278 polymorphism and MI did not vary substantially by excluding any one study. However, the heterogeneity among the selected studies varies substantially by excluding the study from the Pakistan population. We found even more significant association between rs10757278 polymorphism and MI in pooled population, p = 3.55 × 10−53, after excluding the study from the Pakistan population. In summary, previous studies reported weak or no significant association between rs10757278 polymorphism and MI. Interestingly, our analysis suggests that rs10757278 polymorphism is significantly associated with MI susceptibility by analyzing large-scale samples.

  9. Association between BDNF-rs6265 and obesity in the Boston Puerto Rican Health Study

    Science.gov (United States)

    The objective of this study is to examine a functional variant (rs6265) in the BDNF gene interacting with dietary intake modulate obesity traits in the Boston Puerto Rican Health Study population. BDNF rs6265 was genotyped in 1147 Puerto Ricans (aged 45-75 years), and examined for association with o...

  10. Impact of host IL28B rs12979860, rs8099917 in interferon responsiveness and advanced liver disease in chronic genotype 3 hepatitis C patients.

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    Rushna Firdaus

    Full Text Available BACKGROUND AND AIMS: Genetic polymorphisms near interleukin 28B gene are associated with spontaneous and treatment induced clearance of hepatitis C virus (HCV. Our objective was to evaluate the impact of interleukin 28B single nucleotide polymorphism (rs12979860, rs8099917 variability in HCV genotype 3 infected populations. METHODS: 400 hepatitis C seroreactive patients from different population groups in Eastern and North Eastern part of India were assessed for host and viral genotypic analysis. 83 HCV genotype 3 infected patients were administered pegylated interferon- ribavirin therapy. Viral genotyping was performed using nested reverse transcriptase-PCR followed by direct sequencing methods. Host interleukin 28B genotyping was performed using real-time PCR based single nucleotide polymorphism analysis. RESULTS: Out of 400 hepatitis C seroreactive individuals, 73.25% were found to be RNA positive. HCV genotype 3 (65.87% was found to be the major circulating strain in this region followed by genotype 1 (32.08%. rs12979860 CC genotype was significantly associated with sustained virological response in HCV genotype 3 infected population. In patients achieving rapid virological response, favourable CC/TT allele at rs12979860, rs8099917 was found to be predominant at both the alleles at 77%, 73.2% respectively; whereas in case of patients with relapsed HCV infection CT, TG alleles were found to be predominant. Additionally, CC genotypes at rs12979860 were found to be associated with sustained virological response in patients with high viral load (OR = 6.75, 0.05rs12979860 TT, rs8099917 GG alleles were present in 34%, 27.6% patients with relapsed HCV infection respectively. Also unfavourable CT, TG genotypes were found to be predominant in patients with advanced stages of liver disease. CONCLUSION: CC, TT the two favourable markers at SNPs rs12979860 and rs8099917 are strongly associated with sustained virological response

  11. Association of polymorphisms of rs179247 and rs12101255 in thyroid stimulating hormone receptor intron 1 with an increased risk of Graves' disease: A meta-analysis.

    Science.gov (United States)

    Gong, Jing; Jiang, Shu-Jun; Wang, Ding-Kun; Dong, Hui; Chen, Guang; Fang, Ke; Cui, Jin-Rui; Lu, Fu-Er

    2016-08-01

    The polymorphisms of thyroid stimulating hormone receptor (TSHR) intron 1 rs179247 and rs12101255 have been found to be associated with Graves' disease (GD) in genetic studies. In the present study, we conducted a meta-analysis to examine this association. Two reviewers systematically searched eligible studies in PubMed, Web of Science, Embase and China Biomedical Literature Database (CBM). A meta-analysis on the association between GD and TSHR intron 1 rs179247 or rs12101255 was performed. The odd ratios (OR) were estimated with 95% confidence interval (CI). Meta package in R was used for the analyses. Seven articles (13 studies) published between 2009 and 2014, involving 5754 GD patients and 5768 controls, were analyzed. The polymorphism of rs179247 was found to be associated with an increased GD risk in the allele analysis (A vs. G: OR=1.40, 95% CI=1.33-1.48) and all genetic models (AA vs. GG: OR=1.94, 95% CI=1.73-2.19; AA+AG vs. GG: OR=1.57, 95% CI=1.41-1.74; AA vs. AG+GG: OR=1.54, 95% CI=1.43-1.66). The site rs12101255 also conferred a risk of GD in the allele analysis (T vs. C: OR=1.50, 95% CI=1.40-1.60) and all genetic models (TT vs. CC: OR=2.22, 95% CI=1.92-2.57; TT+TC vs. CC: OR=1.66, 95% CI=1.50-1.83; TT vs. TC+CC: OR=1.74, 95% CI=1.53-1.98). Analysis of the relationship between rs179247 and Graves' ophthalmopathy (GO) showed no statistically significant correlation (A vs. G: OR=1.02, 95% CI=0.97-1.07). Publication bias was not significant. In conclusion, GD is associated with polymorphisms of TSHR intron 1 rs179247 and rs12101255. There is no association between rs179247 SNPs and GO. PMID:27465319

  12. An association study between DLGAP1 rs11081062 and EFNA5 rs26728 polymorphisms with obsessive–compulsive disorder in a Chinese Han population

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    Li J

    2015-04-01

    Full Text Available Jiang Li,1 Jiajia Cui,2 Xiuhai Wang,3 Jianhua Ma,4 Haitao Niu,4 Xu Ma,5–7 Xinhua Zhang,2,4 Shiguo Liu8 1Physiatry Department, The Affiliated Hospital of Qingdao University, 2Department of Psychiatry, 3Department of Genetics, Medical College, Qingdao University, 4The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 5Graduate School, Peking Union Medical College, 6National Research Institute for Family Planning, 7World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, People’s Republic of China; 8Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China Background: A recent genome-wide association study indicated that the single nucleotide polymorphisms (SNPs rs11081062 in DLGAP1 and rs26728 in EFNA5 were associated with obsessive–compulsive disorder (OCD in Caucasians. The present case–control association study assessed the global relevance of these two SNPs with respect to OCD subtypes in a Chinese Han population. Methods: We recruited 320 OCD patients and 431 age- and sex-matched controls from a Chinese Han population. rs11081062 and rs26728 SNPs were genotyped by real-time TaqMan polymerase chain reaction, and the chi-squared test was used to compare allele and genotype frequencies of variants between the two groups. Results: No significant differences were found in allele or genotype frequencies of DLGAP1 rs11081062 and EFNA5 rs26728 between the OCD and control groups. Moreover, consistently negative results were observed when classifying by sex, onset age, and comorbidity. However, on analyzing OCD subphenotypes, significant associations were observed between rs11081062 and the presence of contamination obsessions and cleaning compulsions (χ2=7.724, P=0.021 by genotype; χ2=3.745, P=0.053 by allele; and χ2=0.821, P=0.365 by genotype, χ2=27.809, P=0.000 by allele, respectively, and rs26728 with the presence of

  13. Association of polymorphisms hOGG1 rs1052133 and hMUTYH rs3219472 with risk of nasopharyngeal carcinoma in a Chinese population

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    Xie Y

    2016-02-01

    Full Text Available Ying Xie,2 Yuan Wu,3 Xunzhao Zhou,3 Mengwei Yao,3 Sisi Ning,3 Zhengbo Wei1 1Department of Head and Neck Tumor Surgery, Affiliated Tumor Hospital of Guangxi Medical University, 2Guangxi Key Laboratory for High-Incidence Tumor Prevention and Treatment, Experimental Center of Medical Science of Guangxi Medical University,3Graduate School of Guangxi Medical University, Nanning, People’s Republic of China Abstract: This case–control study investigates the possible relationships between the single-nucleotide polymorphisms rs1052133 in the human 8-oxoguanine DNA glycosylase 1 (hOGG1 gene and rs3219472 in the human MutY glycosylase homologue (hMUTYH gene and the risk of nasopharyngeal carcinoma (NPC. The two polymorphisms were genotyped in 488 unrelated NPC patients and 573 cancer-free controls. Genotype GG at rs1052133 was associated with significantly lower NPC risk than genotypes GC + CC (odds ratio [OR] 0.770, 95% confidence interval [CI] 0.595–0.996, P=0.012. In subgroup analyses, subjects with genotype GG at rs1052133 were at lower risk of NPC than those with GC or CC among individuals older than 40 years (OR 0.706, 95% CI 0.524–0.950, women (OR 0.571, 95% CI 0.337–0.968, and those with no smoking history (OR 0.634, 95% CI 0.463–0.868. No significant association was seen between polymorphisms at hMUTYH rs3219472 and the risk of NPC. However, gene–gene interaction analysis showed that subjects with genotype CC at rs1052133 and genotype AA at rs3219472 (CC/AA were at 2.887-fold higher risk of NPC than those with GG/GG, 3.183-fold higher risk than those with GG/GA, and 3.392-fold higher risk than those with GG/AA. Our results suggest that hOGG1 rs1052133 polymorphism may play an important role in NPC pathogenesis, especially among women, >40 years old, and those with no smoking history. The hMUTYH rs3219472 polymorphism may interact with hOGG1 rs1052133 polymorphism to influence susceptibility to NPC. Keywords: nasopharyngeal

  14. Distinct role of the Fas rs1800682 and FasL rs763110 polymorphisms in determining the risk of breast cancer among Han Chinese females

    Science.gov (United States)

    Wang, Meng; Wang, Zheng; Wang, Xi-Jing; Jin, Tian-Bo; Dai, Zhi-Ming; Kang, Hua-Feng; Guan, Hai-Tao; Ma, Xiao-Bin; Liu, Xing-Han; Dai, Zhi-Jun

    2016-01-01

    Background In recent years, studies have demonstrated that polymorphisms in the promoters of Fas and FasL are significantly associated with breast cancer risk. However, the results of these studies were inconsistent. This case–control study was performed to explore the associations between Fas rs1800682 and FasL rs763110 polymorphisms and breast cancer. Materials and methods A hospital-based case–control study of 560 Han Chinese females with breast cancer (583 controls) was conducted. The MassARRAY system was used to search for a possible association between the disease risk and the two single nucleotide polymorphisms, Fas rs1800682 and FasL rs763110. Statistical analyses were performed using SNPStats software to conduct Pearson’s chi-square tests in five different genetic models. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated after adjustment to age and body mass index. PHASE v2.1 software was used to reconstruct all common haplotypes. Results A statistically significant association was found between Fas rs1800682 and increased breast cancer risk (AG vs AA: OR =1.37, 95% CI =1.06–1.78; AA+AG vs GG: OR =1.32, 95% CI =1.04–1.66), and also it was found that the FasL rs763110 polymorphism may decrease the risk. Stratified analyses demonstrated that the rs763110 polymorphism was associated with lower breast cancer risk among postmenopausal females (heterozygote model: OR =0.69, 95% CI =0.49–0.97; dominant model: OR =0.70, 95% CI =0.51–0.96). The T allele of rs763110 was also associated with a decreased risk of lymph node metastasis (allele model: OR =0.75, 95% CI =0.57–0.97) and an increased risk of the breast cancer being human epidermal growth factor receptor 2 positive (allele model: OR =1.37, 95% CI =1.03–1.18). Moreover, haplotype analysis showed that Ars1800682Trs763110 was associated to a statistically significant degree with lower risk of breast cancer (OR =0.70, 95% CI =0.53–0.91). Conclusion These data suggest that

  15. Abundance analysis of the recurrent nova RS Ophiuchi (2006 outburst)

    CERN Document Server

    Das, Ramkrishna

    2015-01-01

    We present an analysis of elemental abundances of ejecta of the recurrent nova RS Oph using published optical and near-infrared spectra during the 2006 outburst. We use the CLOUDY photoionization code to generate synthetic spectra by varying several parameters, the model generated spectra are then matched with the observed emission line spectra obtained at two epochs. We obtain the best fit model parameters through the $\\chi^{2}$ minimization technique. Our model results fit well with observed optical and near-infrared spectra. The best-fit model parameters are compatible with a hot white dwarf source with T$_{BB}$ of 5.5 - 5.8 $\\times$ 10$^{5}$ K and roughly constant a luminosity of 6 - 8 $\\times$ 10$^{36}$ ergs s$^{-1}$. From the analysis we find the following abundances (by number) of elements with respect to solar: He/H = 1.8 $\\pm$ 0.1, N/H = 12.0 $\\pm$ 1.0, O/H = 1.0 $\\pm$ 0.4, Ne/H = 1.5 $\\pm$ 0.1, Si/H = 0.4 $\\pm$ 0.1, Fe/H = 3.2 $\\pm$ 0.2, Ar/H = 5.1 $\\pm$ 0.1, and Al/H = 1.0 $\\pm$ 0.1, all other elem...

  16. The axisymmetric envelopes of RS Cnc and EP Aqr

    CERN Document Server

    Bertre, T Le; Nhung, P T; Winters, J M

    2016-01-01

    We report on observations obtained at IRAM on two semi-regular variable Asymptotic Giant Branch (AGB) stars, RS Cnc and EP Aqr, undergoing mass loss at an intermediate rate of ~ 10^-7 solar mass per year. Interferometric data obtained with the Plateau-de-Bure interferometer (NOEMA) have been combined with On-The-Fly maps obtained with the 30-m telescope in the CO(1-0) and (2-1) rotational lines. The spectral maps of spatially resolved sources reveal an axisymmetric morphology in which matter is flowing out at a low velocity (~ 2 km/s) in the equatorial planes, and at a larger velocity (~ 8 km/s) along the polar axes. There are indications that this kind of morpho-kinematics is relatively frequent among stars at the beginning of their evolution on the Thermally-Pulsing AGB, in particular among those that show composite CO line profiles, and that it might be caused by the presence of a companion. We discuss the progress that could be expected for our understanding of the mass loss mechanisms in this kind of sou...

  17. Early Super Soft Source spectra in RS Oph

    CERN Document Server

    Ness, Jan-Uwe

    2015-01-01

    Recent Swift X-ray monitoring campaigns of novae have revealed extreme levels of variability during the early super-soft-source (SSS) phase. The first time this was observed was during the 2006 outburst of the recurrent nova RS Oph which was also extensively covered by grating observations with XMM-Newton and Chandra. I focus here on an XMM-Newton observation taken on day 26.1, just before Swift confirmed the start of the SSS phase, and a Chandra observation taken on day 39.7. The first observation probes the evolution of the shock emission produced by the collision of the nova ejecta with the stellar wind of the companion. The second observation contains bright SSS emission longwards of 15A while at short wavelengths, the shock component can be seen to have hardly changed. On top of the SSS continuum, additional emission lines are clearly seen, and I show that they are much stronger than those seen on day 26.1, indicating line pumping caused by the SSS emission. The lightcurve on day 39.7 is highly variable ...

  18. Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients

    OpenAIRE

    Raquel López-Mejías; Fernanda Genre; Sara Remuzgo-Martínez; Montserrat Robustillo-Villarino; Mercedes García-Bermúdez; Javier Llorca; Alfonso Corrales; Carlos González-Juanatey; Begoña Ubilla; Miranda-Filloy, José A.; Verónica Mijares; Trinitario Pina; Ricardo Blanco; Alegre-Sancho, Juan J.; Ramírez Huaranga, Marco A.

    2015-01-01

    OBJECTIVES: To determine whether the interleukin-33 (IL-33)-interleukin-1 receptor like 1 (IL-1RL1) signaling pathway is implicated in the risk of subclinical atherosclerosis in patients with rheumatoid arthritis (RA). METHODS: A total of 576 Spanish RA patients from Northern Spain were genotyped for 6 well-known IL33-IL1RL1 polymorphisms (IL33 rs3939286, IL33 rs7025417, IL33 rs7044343, IL1RL1 rs2058660, IL1RL1 rs2310173 and IL1RL1 rs13015714) by TaqMan genotyping assay. The presence of subcl...

  19. Genetic Association of CHAT rs3810950 and rs2177369 Polymorphisms with the Risk of Alzheimer’s Disease: A Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Yong Liu

    2016-01-01

    Full Text Available Choline acetyltransferase (CHAT rs3810950 and rs2177369 polymorphisms have been implicated in susceptibility to Alzheimer’s disease (AD. Due to the inconsistent results from previous studies, a meta-analysis was performed to estimate the association between these polymorphisms and AD risk more precisely. Pooled results of our meta-analysis indicated CHAT rs2177369 polymorphism was correlated with decreasing AD risk in one of five genetic models (dominant: OR = 0.77, 95% CI: 0.62–0.96, while rs3810950 mutant was associated with AD development in three models (allelic: OR = 1.18, 95% CI: 1.01–1.37, homozygous: OR = 1.63, 95% CI: 1.09–2.42, and recessive: OR = 1.65, 95% CI: 1.20–2.26. In subgroup analysis by ethnicity, the association between CHAT rs3810950 polymorphism and AD risk was just found in the recessive model (OR = 1.47, 95% CI: 1.05–2.07 among Caucasians, while four genetic models (allelic: OR = 1.23, 95% CI: 1.01–1.48; homozygous: OR = 2.24, 95% CI: 1.48–3.39; dominant: OR = 1.21, 95% CI: 1.06–1.40; and recessive: OR = 2.18, 95% CI: 1.45–3.29 assumed this association in Asians. In conclusion, our meta-analysis indicated CHAT rs2177369 polymorphism might play a protective role in AD, while rs3810950 variant was a risk factor for AD but its single heterozygous mutations might not influence susceptibility to AD.

  20. Association of ADORA1 rs2228079 and ADORA2A rs5751876 Polymorphisms with Gilles de la Tourette Syndrome in the Polish Population.

    Directory of Open Access Journals (Sweden)

    Piotr Janik

    Full Text Available Gilles de la Tourette syndrome (GTS is a neurodevelopmental disorder characterized by motor and vocal tics. Hyperactivity of dopaminergic transmission is considered a prime abnormality in the pathophysiology of tics. There are reciprocal antagonistic interactions between adenosine and dopamine transmission. The aim of the study was to analyze the association of two polymorphisms, rs2228079 in ADORA1 and rs5751876 in ADORA2A, with the risk of GTS and co-morbid disorders.A total of 162 Polish GTS patients and 270 healthy persons were enrolled in the study. Two polymorphisms were selected on the basis of knowledge of SNPs frequencies in ADORA1 and ADORA2A. Chi-square test was used for allelic and genotypic association studies. Association of genotypes with age of tic onset was analyzed with Mann-Whitney test. Multivariate logistic regression was used to find independent predictors of GTS risk.We found that the risk of GTS was associated with rs2228079 and rs5751876 polymorphisms. The GG+GT genotypes of rs2228079 in ADORA1 were underrepresented in GTS patients (p = 0.011, whereas T allele of rs5751876 in ADORA2A was overrepresented (p = 0.017. The GG genotype of rs2228079 was associated with earlier age of tic onset (p = 0.046. We found also that the minor allele G of rs2228079 was more frequent in GTS patients with depression as compared to the patients without depression (p = 0.015. Also the genotype GG was significantly more frequent in patients with obsessive compulsive disorder/behavior (OCD/OCB, p = 0.021 and depression (p = 0.032, as compared to the patients without these co-morbidities. The minor allele T frequency of rs5751876 was lower in GTS patients with co-morbid attention deficit hyperactivity disorder (p = 0.022, and TT+TC genotypes were less frequent in the non-OCD anxiety disorder group (p = 0.045.ADORA1 and ADORA2A variants are associated with the risk of GTS, co-morbid disorders, and may affect the age of tic onset.

  1. RS-1100柴油加氢脱硫催化剂的研制%THE DEVELOPMENT OF RS-1100 DIESEL HYDRODESULFURIZATION CATALYST

    Institute of Scientific and Technical Information of China (English)

    王锦业; 丁石; 李会峰; 王哲

    2012-01-01

    采用合适的拟薄水铝石制备氧化铝载体,并以浸渍法制备NiMo/Al2O3催化剂,找到催化剂中适宜的Ni/(Ni+ Mo)原子比,在浸渍液中引入适量的助剂和有机络合剂可以提高NiMo/Al2O3催化剂的活性.采用拉曼光谱和紫外-可见光谱仪对浸渍液进行表征,结果表明:浸渍液中存在杂多酸阴离子[P2 Mo5 O23]6-;络合剂与Ni离子也存在相互作用.通过制备条件优化,研制出高活性加氢脱硫催化剂RS-1100.中型装置评价结果表明,RS-1100催化剂的柴油超深度加氢脱硫活性比工业参比剂RS-1000更高,采用RS-1100催化剂在合适的加氢反应条件下可以生产满足欧Ⅴ排放标准的柴油.%NiMo/A1-2O3 catalyst was prepared by impregnation method using alumina support from appropriate pseudo-boehmite. The effect of Ni/(Ni + Mo) atomic ratio on the activity of NiMo/A1-2O3catalyst was investigated and optimized ratio was acquired. The activity of NiMo/A1-2O3 catalyst could be further improved by adding optimum amount of phosphorus promoter and chelating agent into the impregnation solution. The characterization of said impregnation solution by Raman spectroscopy and UV-Vis spectrophotometer showed that phosphorus-molybdenum heteropolyanions of [P2MO5O23]6- existed in the solution, besides, some interactions between chelating agent and Ni2+cations also happened. By optimizing preparation conditions, RS-1100 hydrodesulfurization catalyst with high activity was developed. The pilot-plant test results show that the activity of RS-1100 catalyst is higher than that of commercial RS-1000 catalyst at ultra-deep hydrodesulfurization stage, whereas, the bulk density of RS-1100 catalyst is lower. Diesel oil meeting European emission standard V can be produced by RS-1100 catalyst under suitable hydrogenation reaction conditions.

  2. Permanent active longitudes and activity cycles on RS CVn stars

    Science.gov (United States)

    Berdyugina, Svetlana V.; Tuominen, Ilkka

    1998-08-01

    A new analysis of the published long-term photometric observations has revealed permanent active-longitude structures in four RS CVn stars: EI Eri, II Peg, sigma Gem, and HR 7275. Two active longitudes separated by half of the period are found to dominate on the surface during all available seasons. The positions of the longitudes on three stars (EI Eri, II Peg, HR 7275) are migrating in the orbital reference frame, and there is no preferred orientation with respect to the line of centres in the binaries. The rate of migration is approximately constant. In case of sigma Gem the active longitude migration is synchronized with the orbital motion in the direction of the line of centres in the binary. The active region lifetimes can be longer than the time span of the observations (>=15 yr). The periods of the active longitude rotation are determined: for EI Eri 1fd 9510, for II Peg 6fd 7066, for sigma Gem 19fd 604, for HR 7275 28fd 263. Long-term activity cycles of the stars are discovered from the analysis of the relative contribution of the two longitudes to the photometric variability. One longitude is found to be usually more active than the other at a given moment, and the change of the activity level between the longitudes is cyclic with periods of years. The switch of the activity takes a much shorter time, about a few months, similar to the ``flip-flop'' phenomenon found for FK Com stars. Moments of switching are regarded as new tracers of the activity, and total cycles, which return activity to the same longitude, are found to be for EI Eri 9.0 yr, for II Peg 9.3 yr, for sigma Gem 14.9 yr, for HR 7275 17.5 yr.

  3. do município de Torres/RS

    Directory of Open Access Journals (Sweden)

    Simone Guerra Vidal

    2006-01-01

    Full Text Available This study it had as objective to evaluate the present fluoride concentration in the water of supply fluoridation in Torres – RS, for a period of 7 months. The samples had been collected monthly in 8 different points of the city, which also represented the population supplied and in the treatment station (ETA. The method used in the analysis of the samples was the ion-specific electrode, being that to each evaluation the device was calibrated. The results had demonstrated that it had an oscillation in the fluorine concentration that varied of 0,29 the 0,91 ppmF/L during the evaluated period. The medium of the fluoride concentration between all the samples was 0,61 ppmF/L and the mediana was 0,62 ppmF/L. In the ETA it was observed that in 71,4% of the collected months the level of the fluoride concentration was considered inadequate, being that the lesser joined value was 0,33 ppmF/L and the greater was of 0,91 ppmF/L. Of the 60 collected samples, 26 (43,3% had presented the adequate fluoride concentration (between 0,6 and 0,9 ppmF/L and 34 (56,7% had presented inadequate levels. In this study we can conclude that it had an oscillation of the fluoridation in the water of supplying of the Torres, what it can intervene with the benefits waited for the fluoridation in the studied population.

  4. Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

    Science.gov (United States)

    Ranade, Ranae M.; Zhang, Zhongsheng; Dranow, David M.; Myers, Janette B.; Choi, Ryan; Nakazawa Hewitt, Steve; Edwards, Thomas E.; Davies, Douglas R.; Lorimer, Donald; Boyle, Stephen M.; Barrett, Lynn K.; Buckner, Frederick S.; Fan, Erkang; Van Voorhis, Wesley C.

    2016-01-01

    We investigated Brucella melitensis methionyl-tRNA-synthetase (BmMetRS) with molecular, structural and phenotypic methods to learn if BmMetRS is a promising target for brucellosis drug development. Recombinant BmMetRS was expressed, purified from wild type Brucella melitensis biovar Abortus 2308 strain ATCC/CRP #DD-156 and screened by a thermal melt assay against a focused library of one hundred previously classified methionyl-tRNA-synthetase inhibitors of the blood stage form of Trypanosoma brucei. Three compounds showed appreciable shift of denaturation temperature and were selected for further studies on inhibition of the recombinant enzyme activity and cell viability against wild type B. melitensis strain 16M. BmMetRS protein complexed with these three inhibitors resolved into three-dimensional crystal structures and was analyzed. All three selected methionyl-tRNA-synthetase compounds inhibit recombinant BmMetRS enzymatic functions in an aminoacylation assay at varying concentrations. Furthermore, growth inhibition of B. melitensis strain 16M by the compounds was shown. Inhibitor-BmMetRS crystal structure models were used to illustrate the molecular basis of the enzyme inhibition. Our current data suggests that BmMetRS is a promising target for brucellosis drug development. However, further studies are needed to optimize lead compound potency, efficacy and safety as well as determine the pharmacokinetics, optimal dosage, and duration for effective treatment. PMID:27500735

  5. Meta-Analysis of Low Density Lipoprotein Receptor (LDLR rs2228671 Polymorphism and Coronary Heart Disease

    Directory of Open Access Journals (Sweden)

    Huadan Ye

    2014-01-01

    Full Text Available Low density lipoprotein receptor (LDLR can regulate cholesterol metabolism by removing the excess low density lipoprotein cholesterol (LDL-C in blood. Since cholesterol metabolism is often disrupted in coronary heart disease (CHD, LDLR as a candidate gene of CHD has been intensively studied. The goal of our study is to evaluate the overall contribution of LDLR rs2228671 polymorphism to the risk of CHD by combining the genotyping data from multiple case-control studies. Our meta-analysis is involved with 8 case-control studies among 7588 cases and 9711 controls to test the association between LDLR rs2228671 polymorphism and CHD. In addition, we performed a case-control study of LDLR rs2228671 polymorphism with the risk of CHD in Chinese population. Our meta-analysis showed that rs2228671-T allele was significantly associated with a reduced risk of CHD (P=0.0005, odds ratio (OR = 0.83, and 95% confidence interval (95% CI = 0.75–0.92. However, rs2228671-T allele frequency was rare (1% and was not associated with CHD in Han Chinese (P=0.49, suggesting an ethnic difference of LDLR rs2228671 polymorphism. Meta-analysis has established rs2228671 as a protective factor of CHD in Europeans. The lack of association in Chinese reflects an ethnic difference of this genetic variant between Chinese and European populations.

  6. Mysterious a6-containing nAChRs: function, pharmacology, and pathophysiology

    Institute of Scientific and Technical Information of China (English)

    Ke-chun YANGU; Guo-zhang JIN; Jie WU

    2009-01-01

    Neuronal nicotinic acetylcholine receptors (nAChRs) are the superfamily of ligand-gated ion channels and widely expressed throughout the central and peripheral nervous systems. nAChRs play crucial roles in modulating a wide range of higher cognitive functions by mediating presynaptic, postsynaptic, and extrasynaptic signaling. Thus far, nine alpha (a2-alO) and three beta ((32, (33, and (34) subunits have been identified in the CNS, and these subunits assemble to form a diversity of functional nAChRs. Although a4(32- and a7-nAChRs are the two major functional nAChR types in the CNS, a6*-nAChRs are abundantly expressed in the midbrain dopaminergic (DAergic) system, including mesocorticolimbic and nigrostriatal pathways, and particularly present in presynaptic nerve terminals. Recently, functional and pharmacological profiles of a6*-nAChRs have been assessed with the use of a6 subunit blockers such as a-conotoxin Mil and PIA, and also by using a6 subunit knockout mice. By modulating DA release in the nucleus accumbens (NAc) and modulating GABA release onto DAergic neurons in the ventral tegmental area (VTA), a6*-nAChRs may play important roles in the mediation of nicotine reward and addiction. Furthermore, a6*-nAChRs in the nigrostriatal DAergic system may be promising targets for selective preventative treatment of Parkinson's disease (PD). Thus, a6*-nAChRs may hold promise for future clinical treatment of human disorders, such as nicotine addiction and PD. In this review, we mainly focus on the recent advances in the understanding of ct6*-nAChR function, pharmacology and pathophysiology.

  7. Variation in the Group B Streptococcus CsrRS Regulon and Effects on Pathogenicity▿ †

    OpenAIRE

    Jiang, Sheng-Mei; Ishmael, Nadeeza; Hotopp, Julie Dunning; Puliti, Manuela; Tissi, Luciana; Kumar, Nikhil; Cieslewicz, Michael J.; Tettelin, Hervé; Wessels, Michael R.

    2008-01-01

    CsrRS (or CovRS) is a two-component regulatory system that controls expression of multiple virulence factors in the important human pathogen group B Streptococcus (GBS). We now report global gene expression studies in GBS strains 2603V/R and 515 and their isogenic csrR and csrS mutants. Together with data reported previously for strain NEM316, the results reveal a conserved 39-gene CsrRS regulon. In vitro phosphorylation-dependent binding of recombinant CsrR to promoter regions of both positi...

  8. Single nucleotide polymorphism rs1052501 associated with monoclonal gammopathy of undetermined significance and multiple myeloma

    OpenAIRE

    Greenberg, Alexandra J.; Lee, Adam M.; Daniel J. Serie; McDonnell, Shannon K; Cerhan, James R.; Liebow, Mark; Larson, Dirk R.; Colby, Colin L.; Norman, Aaron D.; Kyle, Robert A.; Rajkumar, S. Vincent; Diasio, Robert B.; Susan L Slager; Vachon, Celine M.

    2012-01-01

    Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant precursor to multiple myeloma (MM). Though several genetic variants have been identified for MM, none have been identified for MGUS. Recently, Broderick et al. conducted a GWAS of MM and identified three novel loci at 3p22.1 (rs1052501), 7p15.3 (rs4487645) and 2p23.3 (rs6746082) associated with MM risk. We examined the association of these variants with MGUS in a clinic-based case-control study of 391 MGUS cases and 3...

  9. Determinantes e padrões de utilização da bicicleta e acidentes de trânsito sofridos por ciclistas trabalhadores da cidade de Pelotas, Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Giancarlo Bacchieri

    2005-10-01

    Full Text Available Um estudo transversal de base-populacional foi realizado em Pelotas, sul do Brasil, objetivando pesquisar os determinantes e padrões de utilização da bicicleta como modo de transporte para o trabalho. Foram também descritos os acidentes ocorridos nos últimos 12 meses no deslocamento de ida e volta para o trabalho e a utilização de equipamentos de segurança na bicicleta. A amostra incluiu 1.705 trabalhadores com 15 anos ou mais de idade, residentes na zona urbana, que utilizavam modos de transporte para o trabalho. Análises bruta e ajustada foram realizadas por meio de regressão de Poisson, considerando o efeito do delineamento. A prevalência de utilização da bicicleta foi de 17,2% (IC95%: 15,4-19,0. Trabalhadores homens, com baixa escolaridade e nível econômico mais baixo apresentaram as maiores prevalências. Menos de 1,0% das bicicletas possuía os equipamentos de segurança exigidos pelo Código de Trânsito Brasileiro e 15,0% não tinham freios. Aproximadamente 6,0% desses trabalhadores sofreram acidentes de trânsito com lesões corporais nos últimos 12 meses. Concluímos que trabalhadores que utilizam bicicleta como modo de transporte são prioritários para intervenções preventivas relacionadas a acidentes de trânsito.

  10. SHRIMP U-Pb age and high temperature conditions of the collisional metamorphism in the Várzea do Capivarita Complex: Implications for the origin of Pelotas Batholith, Dom Feliciano Belt, southern Brazil

    Science.gov (United States)

    Philipp, Ruy Paulo; Bom, Francisco Molina; Pimentel, Márcio Martins; Junges, Sérgio Luiz; Zvirtes, Gustavo

    2016-03-01

    The Várzea do Capivarita Complex is composed of pelitic gneisses with subordinate calc-silicate rock, marble and rare quartzite. It is part of the neoproterozoic Dom Feliciano Belt, in southern Brazil. The gneisses are associated to veins and tabular leucogranite bodies, which are the product of anatexis of the pelitic gneiss. The paragneisses of the Várzea do Capivarita Complex are tectonically juxtaposed to orthogneisses of the Arroio dos Ratos Complex. This complex is exposed as megaxenoliths in granites of the Encruzilhada do Sul Suite and as smaller fragments in the Quitéria and Cordilheira Granites, all part of the Pelotas Batholith. The metamorphic foliation is oriented to N30°W, with dips between 35 and 55° to the SW and mineral lineation is suborizontal with rake ranging from 15° to 30° and down dip to NW and SE, suggesting deformation associated with a transpressive system. Based on the paragenesis garnet-cordierite-sillimanite-biotite, metamorphism occurred at 720-820° C and pressure of 8-9 kbar, characterizing it as of intermediate pressure and high temperature series. Zircon grains of one sample of garnet-cordierite-sillimanite-biotite gneiss and one of peraluminous leucogranite was dated by the U-Pb SHRIMP method. The paragneiss metamorphic zircon yielded an age of 619 ± 4.3 Ma interpreted as an age of the main metamorphic event, whereas igneous zircon grains from the leucogranite indicates that magma crystallization took place at 620 ± 6.3 Ma. The main metamorphic foliation (S2) of the paragneiss and the leucogranite magmatic foliation (S0) are parallel to each other, indicating that they were formed during the same event. This suggests that anatexis of the paragneisses of the Várzea do Capivarite Complex generated the peraluminous leucogranites right after the climax of the collisional metamorphism.

  11. Associations between FAS rs2234767 and FASL rs763110 polymorphisms and the risk of lung cancer: a meta-analysis of 39,736 subjects

    Directory of Open Access Journals (Sweden)

    Yu XJ

    2016-04-01

    Full Text Available Xiongjie Yu,1,* Yanli Li,2,* Yuandong Yu,1 Jinhua Lei,1 Guoxing Wan,1 Fengjun Cao1 1Department of Oncology, 2Department of Endocrinology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, People’s Republic of China *These authors contributed equally to this work Background: Previous studies have investigated the associations between the common polymorphisms in FAS/FASL genes and lung cancer risk; however, the results remain inconsistent and inconclusive. Hence, we performed a meta-analysis to reassess the relationships between FAS rs2234767 and FASL rs763110 polymorphisms and the risk of lung cancer. Methods: Eligible studies retrieved by an electronic search were pooled to calculate the strength of the associations using the odds ratio (OR and 95% confidence interval (95% CI. Results: A total of 13 case–control studies involving 39,736 subjects (9,237 cases and 10,838 controls on FAS rs2234767 and 8,957 cases and 10,704 controls on FASL rs763110 were included in the meta-analysis. The results showed a significant association between FAS rs2234767 polymorphism and increased risk of lung cancer (A vs G: OR =1.07, 95% CI =1.01–1.13; AA vs GG: OR =1.23, 95% CI =1.06–1.43; AA vs GA + GG: OR =1.24, 95% CI =1.08–1.43. Similar association was also observed in Asian population (AA vs GA + GG: OR =1.30, 95% CI =1.01–1.67 and in the studies with large sample size (A vs G: OR =1.07, 95% CI =1.00–1.14; AA vs GG: OR =1.30, 95% CI =1.07–1.58. However, no significant association between FASL rs763110 polymorphism and lung cancer risk was found other than in the Asian population (CC vs TC + TT: OR =1.35, 95% CI =1.01–1.80. Conclusion: The meta-analysis indicated that FAS rs2234767 polymorphism was significantly associated with an increased risk of lung cancer and FASL rs763110 polymorphism may not contribute to susceptibility to lung cancer other than in Asian population. Keywords: FAS, FAS ligand, polymorphism, lung cancer, meta

  12. Investigating the Correlation between rs1049305 and ‏rs10244884 Polymorphisms of AQP-1 Gene and Menorrhagia ‎in Adolescents

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    S Madani

    2014-02-01

    Results: Regarding ‏‎rs1049305, the C minor allele showed more frequency in patients' group‏ (0.47 vs. 0.37.‎‎ The results revealed that GG genotype presents less probable risk ‎for menorrhagia. ‎‎ rs10244884‎ also shows the same frequency. Conclusion: It can be concluded that both variants are important in pathogenesis of menorrhagia and the results confirm the important role of Aquqporin–1 channel in menstruation as well as endometrium physiology.

  13. Association of rs6265 and rs2030324 polymorphisms in brain-derived neurotrophic factor gene with Alzheimer's disease: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Yan Lin

    Full Text Available BACKGROUND: The association between polymorphisms rs6265 and rs2030324 in brain-derived neurotrophic factor (BDNF and Alzheimer's disease (AD has been widely reported, but the results remain controversial. METHODS: A comprehensive search of Pubmed, Web of Science, China National Knowledge Infrastructure (CNKI, Wanfang Med Online and China Biology Medical literature database (CBM was performed. Pooled odds ratios (ORs with 95% confidence intervals (CIs were calculated using fixed or random-effects models. We excluded the studies with OR>3.0 or OR<0.3 for sensitive analysis. Subgroup analysis by ethnicity, form of AD and gender was carried out. Meta-regression was conducted to explore the potential sources of between-study heterogeneity. RESULTS: 29 articles with 7548 cases and 7334 controls concerning rs6265 and 22 articles with 5796 cases and 5706 controls concerning rs2030324 were included in this meta-analysis. The combined evidence suggested rs6265 contributing significantly to the increased risk of AD in females (codominant: fixed-effects model (FEM: OR = 1.13, 95% CI = 1.04-1.23; dominant: FEM: OR = 1.17, 95% CI = 1.05-1.31, especially for Caucasian females (codominant: FEM: OR = 1.18, 95% CI = 1.03-1.34; dominant: FEM: OR = 1.18, 95% CI = 1.01-1.37 and female late-onset Alzheimer's disease (LOAD patients (codominant: FEM: OR = 1.22, 95% CI = 1.05-1.41; dominant: FEM: OR = 1.23, 95% CI = 1.03-1.46. No evidence indicated an association between rs2030324 with AD in codominant (random-effects model (REM: OR = 1.06, 95% CI = 0.89-1.26 and dominant (REM: OR = 1.05, 95% CI = 0.86-1.27 models. CONCLUSION: This meta-analysis suggested A allele of rs6265 might increase the risk of AD in Caucasian females and female LOAD patients. In addition, no evidence indicated an association between rs2030324 with AD. Further studies are needed to confirm these results.

  14. Association Study between Coronary Artery Disease and rs1333049 and rs10757274 Polymorphisms at 9p21 Locus in South-West Iran

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    Ali Mohammad Foroughmand

    2015-04-01

    Full Text Available Objective: Coronary artery disease (CAD is a multi-factorial and heterogenic disease with atherosclerosis plaques formation in internal wall of coronary artery. Plaque formation results to limitation of the blood reaching to myocardium leading to appearance of some problems, such as ischemia, sudden thrombosis veins and myocardial infarction (MI. Several environmental and genetic factors are involved in prevalence and incident of CAD as follows: hypertension, high low density lipoprotein-cholesterol (LDL-C, age, diabetes mellitus, family history of early-onset heart disease and smoking. According to genome wide association studies (GWAS, five polymorphisms in the 9p21 locus seem to be associated with the CAD. We aimed to evaluate the remarkable association of two polymorphisms at 9p21 locus, rs1333049 and rs10757274, with CAD. Materials and Methods: This experimental study was conducted in Golestan, Aria Hospitals and Genetics Lab of Shahid Chamran University in the city of Ahvaz, Iran, in 2010- 2011. The collected blood samples belonging to 170 CAD patients (case group and 100 healthy individuals (control group were analyzed by tetra-primer amplification refractory mutation system (ARMS-polymerase chain reaction (PCR technique. The results were analyzed using software package used for statistical analysis (SPSS; SPSS Inc., USA version 16. A value of p<0.05 and an odd ratio (OR with 95% confidence intervals (CI were considered significant. Results: The frequencies of CC, CG and GG genotypes for rs1333049 polymorphism in patients were 18.2, 65.3 and 16.5%, while in controls, the related values were 25, 67 and 8%, respectively. GG genotypes of rs1333049 polymorphism in CAD patients were more than control cases (OR: 0.354, 95%CI: 0.138-0.912, p=0.032. The frequencies of AA, AG and GG genotypes for rs10757274 in CAD patients were 8.2, 58.3 and 33.5%, while in controls, the related values were 35, 63 and 2%, respectively. GG Genotype in rs10757274

  15. Association of endothelial nitric oxide synthase gene rs7830 and rs3918188 polymorphisms with essential hypertension in Kazakh of Xinjiang region%新疆哈萨克族内皮型一氧化氮合酶基因rs7830和rs3918188多态性与原发性高血压的相关性

    Institute of Scientific and Technical Information of China (English)

    卢贤贵; 唐斌; 何芳; 张强; 黄刚; 王刚; 邹放君; 邓峰美

    2012-01-01

    AIM; To investigate the correlation between endothelial nitric oxide synthase (eNOS) rs7830 and rs3918188 locus polymorphisms and essential hypertension (EH) in the Kazakh of Xinjiang region. METHODS: Epide-miological case -control study was conducted. DNA was extracted by classic phenol -chloroform method, PCR amplifica-tion and purification. The rs7830 and rs3918188 of eNOS gene in 363 EH patients (EH group) and 370 normotensive con-trols (NT group) in the Kazakh of Xinjiang region were genotyped by the technique of SNaPshot single nucleotide polymor-phism genotyping. The plasma levels of fasting blood glucose, uric acid, cholesterol and triglyceride were measured by bio-chemical methods. Determination of body mass index and waist - hip ratio was also conducted. RESULTS: Age ( P 0. 05 ) . The frequency distribution of CA, CC, AC and AA haplotypes from eNOS gene rs7830 and rs3918188 loci between EH group and NT group also had no difference in the Kazakh of Xinjiang region ( P > 0. 05 ) . CONCLUSION: Age, body mass index and triglyceride are the independent risk factors, while low - density lipoprotein and apolipoprotein Al/B are the independent protective factors for EH in the Kazakh of Xinjiang region. The polymorphisms of eNOS gene rs3918188 and rs7830 loci are not related to EH in the Kazakh of Xin-jiang region.%目的:探讨新疆哈萨克族内皮型一氧化氮合酶(eNOS)基因rs7830和rs3918188位点多态性与原发性高血压(EH)的相关性.方法:采用流行病学的病例-对照研究方法,用经典的酚-氯仿法进行DNA抽取、PCR及纯化,用SNaPshot分型技术对新疆哈萨克族363名EH患者(EH组)和370名正常血压者(NT组)进行eNOS基因rs7830和rs3918188分型,并采用生化技术测定空腹血糖、尿酸、胆固醇、甘油三酯等10项血浆指标,测定体重指数、腰臀比等指标.结果:(1)年龄(P0.05 );(3)新疆哈萨克族eNOS基因rs7830和rs3918188位点所构建的CA、CC、AC和AA 4种单倍型频率在2

  16. Preparation and characterization of ketoprofen loaded eudragit RS polymeric nanoparticles for controlled release

    Science.gov (United States)

    Anh, Nguyen Tuan; Chi, Nguyen T.; Khai Tran, T.; Tuyen Dao, T. P.; Nhan Le, N. T.; Mau Chien, Dang; Hoai, Nguyen To

    2012-12-01

    Nanospheres containing ketoprofen (Keto) and polymer eudragit RS were prepared using an emulsion solvent evaporation method. The ultrasonic probe (VCX500, vibracell) was used as a tool to disperse oil phase into aqueous phase leading to water/oil emulsion. Nanoparticles were successfully prepared and their morphologies and diameters were confirmed by transmission electron microscope (TEM) and dynamic light scattering (DLS), respectively. The result showed that particles were spherical with submicron size. The particle size was dependent on the RS concentration, emulsification tools and the types of organic solvents. For the encapsulation ability, Keto-loaded RS nanoparticle showed 9.8% of Keto in nanoparticle, which was evaluated by high-performance liquid chromatography (HPLC). Moreover, the drug release behavior of Keto-loaded eudragit RS nanoparticle was also investigated in vitro at pH 7.4 and compared to referential profenid.

  17. Site-specific uv crosslinking of minihelix DNA and TrpRS from Bacillus subtilis

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In order to investigate the recognition mechanism and the relationship between structure and function of minihelix DNA with Tryptophanyl-tRNA Synthetase (TrpRS), TrpRS from Bacillus Subtilis was purified. Four minihelix DNAs were chemically synthesized and the photoreactive reagent s4T was incorporated into three of them at the positions of G73, T72 and T55 corresponding to tRNATrp.The apparatus for uv crossiinking was devised and the parameters for uv crosslinking were optimized. The results indicated that the G73 and T72 base of minihelix DNA interacted with TrpRS directly. The uv crosslinking reaction was improved by the dose of uv irradiation and the concentration of both TrpRS and minihelix DNA.``

  18. Trails, RS2477, TransplanGood, Published in 2007, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2007. It is described as 'TransplanGood'. Data by this publisher are often...

  19. Trails, RS2477, centerlines-project, Published in 2006, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2006. It is described as 'centerlines-project'. Data by this publisher are...

  20. Trails, RS2477, picpts-Project, Published in 2006, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2006. It is described as 'picpts-Project'. Data by this publisher are often...

  1. Integrated Application of RS and GIS to Agriculture Land Use Planning

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This paper gives some guidelines of land use planning firstly.A framework of agriculture land use planning is designed based on land use suitability evaluation using integrated technologies of RS and GIS.Further work expected is also given.

  2. Trails, RS2477, UnimprovedRoad, Published in 2005, Millard County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2005. It is described as 'UnimprovedRoad'. Data by this publisher are often...

  3. Trails, RS2477, ImprovedroadPictures, Published in 2005, Millard County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2005. It is described as 'ImprovedroadPictures'. Data by this publisher are...

  4. Trails, RS2477, UnimprovedRoadPictures, Published in 2004, Millard County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, was produced all or in part from Other information as of 2004. It is described as 'UnimprovedRoadPictures'. Data by this publisher are...

  5. A family of RS domain proteins with novel subcellular localization and trafficking

    OpenAIRE

    Kavanagh, Steven J.; Thomas C Schulz; Davey, Philippa; Claudianos, Charles; Russell, Carrie; Peter D. Rathjen

    2005-01-01

    We report the sequence, conservation and cell biology of a novel protein, Psc1, which is expressed and regulated within the embryonic pluripotent cell population of the mouse. The Psc1 sequence includes an RS domain and an RNA recognition motif (RRM), and a sequential arrangement of protein motifs that has not been demonstrated for other RS domain proteins. This arrangement was conserved in a second mouse protein (BAC34721). The identification of Psc1 and BAC34721 homologues in vertebrates an...

  6. A simplified algorithm for correcting both errors and erasures of R-S codes

    Science.gov (United States)

    Reed, I. S.; Truong, T. K.

    1978-01-01

    Using the finite field transform and continued fractions, a simplified algorithm for decoding Reed-Solomon (R-S) codes is developed to correct erasures caused by other codes as well as errors over the finite field GF (q(m), where q is a prime and m is an integer. Such an R-S decoder can be faster and simpler than a decoder that uses more conventional methods.

  7. Nanostructured lipid carrier surface modified with Eudragit RS 100 and its potential ophthalmic functions

    Directory of Open Access Journals (Sweden)

    Zhang W

    2014-09-01

    Full Text Available Wenji Zhang,1,3,* Xuedong Li,2,* Tiantian Ye,3 Fen Chen,3 Shihui Yu,3 Jianting Chen,3 Xinggang Yang,3 Na Yang,2 Jinsong Zhang,2 Jinlu Liu,2 Weisan Pan,3 Jun Kong2 1Department of Pharmaceutics, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China; 2Department of Ophthalmology, The Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Lens Research Laboratory of Liaoning Province, Shenyang, People’s Republic of China; 3Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China *These authors contributed equally to this work Abstract: This study was carried out to evaluate the ocular performance of a cationic Eudragit (EDU RS 100-coated nanostructured lipid carrier (NLC. The genistein encapsulated NLC (GEN-NLC was produced using the melt-emulsification technique followed by surface absorption of EDU RS 100. The EDU RS 100 increased the surface zeta potential from −7.46 mV to +13.60 mV, by uniformly forming a spherical coating outside the NLC surface, as shown by transmission electron microscopy images. The EDU RS 100 on the NLC surface effectively improved the NLC stability by inhibiting particle size growth. The obtained EDU RS 100-GEN-NLC showed extended precorneal clearance and a 1.22-fold increase in AUC (area under the curve compared with the bare NLC in a Gamma scintigraphic evaluation. The EDU RS 100 modification also significantly increased corneal penetration producing a 3.3-fold increase in apparent permeability coefficients (Papp compared with references. Draize and cytotoxicity testing confirmed that the developed EDU RS 100-GEN-NLC was nonirritant to ocular tissues and nontoxic to corneal cells. These results indicate that the NLC surface modified by EDU RS 100 significantly improves the NLC properties and exhibits many advantages for ocular use. Keywords

  8. Performance Analysis of DRA Based OFDM Data Transmission With Respect to Novel High Speed RS Decoding

    OpenAIRE

    Dr. S.V.A.V. Prasad; Anshu Thakur

    2015-01-01

    In this paper, we have analyzed the performance characteristics of OFDM data transmission with regard to a new high speed RS decoding algorithm. The various characteristics identified are mainly speed and accuracy of the transmission irrespective of channel behaviour. We consider two cases viz. data transmission without error control and data transmission with error control. Each of these cases are duly analyzed and it is proven that high speed RS decoding algorithms can actually ...

  9. The Common Variant rs11646213 Is Associated with Preeclampsia in Han Chinese Women

    OpenAIRE

    Wan, Ji-Peng; Zhao, Han; Li, Tao; Li, Chang-Zhong; Wang, Xie-tong; Chen, Zi-Jiang

    2013-01-01

    Background Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This study evaluated the association between preeclampsia and rs11646213. Methods A total of 454 cases and 460 controls were recruited to participate in this study. The single nucleotide polymorphism (SNP)...

  10. Faktor-Faktor Yang Mempengaruhi Kejadian Insomnia di Poliklinik Saraf RS DR. M. Djamil Padang

    OpenAIRE

    Lydia Susanti

    2015-01-01

    Abstrak Faktor risiko seperti usia lanjut, jenis kelamin wanita, penyakit penyerta (depresi dan penyakit lain), status sosial ekonomi rendah menyebabkan insomnia. Penelitian mengenai prevalensi dan faktor-faktor yang mempengaruhi kejadian insomnia di Poliklinik Saraf RS DR. M. Djamil Padang belum pernah dilakukan. Tujuan penelitian ini adalah menentukan faktor-faktor yang mempengaruhi terjadinya insomnia di poliklinik saraf RS DR. M. Djamil Padang. Penelitian ini merupakan penelitian cross se...

  11. Development of Cloud Detection Methods Using CFH, GTS1, and RS80 Radiosondes

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jinqiang; CHEN Hongbin; BIAN Jianchun; XUAN Yuejian; DUAN Yunjun; Maureen CRIBB

    2012-01-01

    The accuracies of three instruments in measuring atmospheric column humidity were assessed during an upper troposphere and lower stratosphere observation campaign conducted from 7 to 13 August 2009 in Kunming,China.The three instruments are a cryogenic frost-point hygrometer (CFH),a Vaisala RS80 radiosonde (RS80),and a GTS1 radiosonde (GTS1).The accuracy of relative humidity (RH) measurements made by the CFH,GTS1,and RS80 was similar between the surface and 500 hPa (~5.5 km above sea level).However,above 500 hPa,the errors in RH measurements made by the RS80,relative to measurements made by the CFH,are much less than those detected with the GTS1.Three different retrieval methods for determining cloud boundaries from CFH,RS80,and GTS1 measurements were developed and take into account the differences in accuracy among the three instruments.The method for the CFH is based on RH thresholds at all levels,which demands high accuracy.Given that the accuracy of RH measurements decreases at higher altitudes,the cloud detection methods for RS80 and GTS1 are different for different altitude ranges.Below 5 km,the methods for the RS80 and the GTS1 are similar to that of the CFH; above 5 km,the methods for the RS80 and the GTS1 are both developed based on the second-order derivatives of temperature and RH with respect to height,but with different criteria applied.Comparisons of cloud-layer retrievals derived from the three measurements are also made.

  12. Association between polymorphism rs6983267 and gastric cancer risk in Chinese population

    Institute of Scientific and Technical Information of China (English)

    Yi Guo; Heng-Jun Gao; Jing Fang; Yan Liu; Hai-Hui Sheng; Xiao-Yan Zhang; Hai-Na Chai; Wei Jin; Ke-Hao Zhang; Chang-Qing Yang

    2011-01-01

    AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk.METHODS: A case-control investigation including212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267,rs7008482 and rs10808555) were examined and establishedthrough polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer.RESULTS: The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype ofrs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Furtherstratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753;OR: 1.916, 95% CI: 1.166-3.150, respectively).CONCLUSION: This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed.

  13. The common variant rs11646213 is associated with preeclampsia in Han Chinese women.

    Directory of Open Access Journals (Sweden)

    Ji-peng Wan

    Full Text Available BACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This study evaluated the association between preeclampsia and rs11646213. METHODS: A total of 454 cases and 460 controls were recruited to participate in this study. The single nucleotide polymorphism (SNP rs11646213 was genotyped by polymerase chain reaction (PCR and direct sequencing. RESULTS: The allele frequency of rs11646213 was significantly different between the preeclampsia and control groups (P = 0.017, OR = 1.36, 95% CI = 1.06-1.76. Differences were particularly significant in the severe preeclampsia subgroup (P = 0.002, OR = 1.54, 95% CI = 1.17-2.03 and the early-onset preeclampsia subgroup (P = 0.004, OR = 1.57, 95% CI = 1.16-2.13. Genotyping analysis showed that the T allele of rs11646213 could confer a risk for preeclampsia, severe preeclampsia and early-onset preeclampsia. CONCLUSIONS: Rs11646213 upstream of the CDH13 gene is associated with preeclampsia in Han Chinese women.

  14. Positive Association between GCKR rs780093 Polymorphism and Coronary Heart Disease in the Aged Han Chinese

    Directory of Open Access Journals (Sweden)

    Jiangfang Lian

    2013-01-01

    Full Text Available Objective. Previous studies have confirmed that GCKR rs780093 polymorphism is associated with triglyceride (TG, a known risk factor of coronary heart disease (CHD. The goal of our study is to explore the association of GCKR rs780093 polymorphism with CHD in Han Chinese population. Methods and Results. A total of 568 CHD cases and 494 non-CHD controls were enrolled in the current case-control study. Genotyping was done using melting temperature shift (Tm-shift approach. Our results also showed that GCKR rs780093 polymorphism was significantly associated with TG level (P=0.0016. Although there was no significant association between cases and controls (P>0.05, a breakdown analysis by age yielded a significant association of GCKR rs780093 polymorphism with CHD in individuals aged 65 and older (genotype: χ2=6.86; df = 2; P=0.03; allele: χ2=4.11; df = 1; P=0.04. Conclusion. Our findings confirmed the contribution of GCKR rs780093 polymorphism to TG metabolism and demonstrated GCKR rs780093 as a risk factor of CHD in individuals aged 65 and older.

  15. Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor.

    Science.gov (United States)

    Olson, Michael E; Nygaard, Tyler K; Ackermann, Laynez; Watkins, Robert L; Zurek, Oliwia W; Pallister, Kyler B; Griffith, Shannon; Kiedrowski, Megan R; Flack, Caralyn E; Kavanaugh, Jeffrey S; Kreiswirth, Barry N; Horswill, Alexander R; Voyich, Jovanka M

    2013-04-01

    Several prominent bacterial pathogens secrete nuclease (Nuc) enzymes that have an important role in combating the host immune response. Early studies of Staphylococcus aureus Nuc attributed its regulation to the agr quorum-sensing system. However, recent microarray data have indicated that nuc is under the control of the SaeRS two-component system, which is a major regulator of S. aureus virulence determinants. Here we report that the nuc gene is directly controlled by the SaeRS two-component system through reporter fusion, immunoblotting, Nuc activity measurements, promoter mapping, and binding studies, and additionally, we were unable identify a notable regulatory link to the agr system. The observed SaeRS-dependent regulation was conserved across a wide spectrum of representative S. aureus isolates. Moreover, with community-associated methicillin-resistant S. aureus (CA MRSA) in a mouse model of peritonitis, we observed in vivo expression of Nuc activity in an SaeRS-dependent manner and determined that Nuc is a virulence factor that is important for in vivo survival, confirming the enzyme's role as a contributor to invasive disease. Finally, natural polymorphisms were identified in the SaeRS proteins, one of which was linked to Nuc regulation in a CA MRSA USA300 endocarditis isolate. Altogether, our findings demonstrate that Nuc is an important S. aureus virulence factor and part of the SaeRS regulon.

  16. Heme sensing in Bacillus thuringiensis: a supplementary HssRS-regulated heme resistance system.

    Science.gov (United States)

    Schmidt, Rachel M; Carter, Micaela M; Chu, Michelle L; Latario, Casey J; Stadler, Sarah K; Stauff, Devin L

    2016-05-01

    Several Gram-positive pathogens scavenge host-derived heme to satisfy their nutritional iron requirement. However, heme is a toxic molecule capable of damaging the bacterial cell. Gram-positive pathogens within the phylum Firmicutes overcome heme toxicity by sensing heme through HssRS, a two-component system that regulates the heme detoxification transporter HrtAB. Here we show that heme sensing by HssRS and heme detoxification by HrtAB occur in the insect pathogen Bacillus thuringiensis We find that in B. thuringiensis, HssRS directly regulates an operon, hrmXY, encoding hypothetical membrane proteins that are not found in other Firmicutes with characterized HssRS and HrtAB systems. This novel HssRS-regulated operon or its orthologs BMB171_c3178 and BMB171_c3330 are required for maximal heme resistance. Furthermore, the activity of HrmXY is not dependent on expression of HrtAB. These results suggest that B. thuringiensis senses heme through HssRS and induces expression of separate membrane-localized systems capable of overcoming different aspects of heme toxicity.

  17. An Xp22.1-p22.2 YAC contig encompassing the disease loci for RS, KFSD, CLS, HYP and RP15 : Refined localization of RS

    NARCIS (Netherlands)

    van de Vosse, E; Bergen, AAB; Meershoek, EJ; Oosterwijk, JC; Gregory, S; Bakker, B; Weissenbach, J; Coffey, AJ; vanOmmen, GJB; DenDunnen, JT

    1996-01-01

    To facilitate the positional cloning of the genes involved in retinoschisis (RS), keratosis follicularis spinulosa decalvans (KFSD), Coffin-Lowry syndrome (CLS), X-linked hypophosphatemic rickets (XLH, locus name HYP) and X-linked dominant cone-rod degeneration (locus name RP 15), we have extended t

  18. Lack of association of IL6R rs2228145 and IL6ST/gp130 rs2228044 gene polymorphisms with cardiovascular disease in patients with rheumatoid arthritis.

    Science.gov (United States)

    López-Mejías, R; García-Bermúdez, M; González-Juanatey, C; Castañeda, S; Miranda-Filloy, J A; Gómez-Vaquero, C; Fernández-Gutiérrez, B; Balsa, A; Pascual-Salcedo, D; Blanco, R; González-Álvaro, I; Llorca, J; Martín, J; González-Gay, M A

    2011-12-01

    Interleukin-6 (IL-6) is a key mediator of inflammation in rheumatoid arthritis (RA) and its actions may be controlled by the IL-6 receptor (IL-6R). IL-6 transducer (IL-6ST/ gp130) is the signal transducing subunit of the IL-6R. We assessed the influence of the IL6R and the IL6ST/gp130 genes in the risk of cardiovascular (CV) disease in RA. For this purpose, 1250 Spanish patients with RA were genotyped for the IL6R rs2228145 and IL6ST/gp130 rs2228044 functional gene polymorphisms. Patients were stratified according to the presence or absence of CV events. Also, a subgroup of patients without CV events was assessed for the presence of subclinical atherosclerosis using two surrogate markers of atherosclerosis (flow-mediated endothelium-dependent vasodilatation and carotid intima-media thickness). No significant differences in the genotype and allele frequencies for both gene polymorphisms between patients with and without CV events were observed. It was also the case when values of surrogate markers of atherosclerosis were compared according to IL6R and IL6ST genotype frequencies. In conclusion, our results do not confirm an association of IL6R rs2228145 and IL6ST/gp130 rs2228044 polymorphisms with CV disease in RA.

  19. Lack of Association between Missense Variants in GRHL3 (rs2486668 and rs545809) and Susceptibility to Non-Syndromic Orofacial Clefts in a Han Chinese Population

    Science.gov (United States)

    He, Miao; Bian, Zhuan

    2016-01-01

    Background Grainyhead-like-3 (GRHL3) was recently identified as the second gene that, when mutated, can leads to Van der Woude syndrome, which is characterized by orofacial clefts (OFC) and lower lip pits. In addition, a missense variant (rs41268753) in GRHL3 confers risk for non-syndromic cleft palate cases of European ancestry. Together with interferon regulatory factor 6 (IRF6), GRHL3 may be associated with the risk of NSOFC which awaits for being verified across different ethnic populations. Objective The aim of this study was to investigate the possible relationship between common functional variants in GRHL3 and susceptibility to NSOFC, especially cleft palate cases, in a Han Chinese population, one of the ethnic groups with the highest birth prevalence of orofacial clefting. Methods Because the allele frequency for rs41268753 minor alleles was zero in our Chinese population, we selected functional single nucleotide polymorphisms (SNPs) spanning GRHL3 with minor allele frequencies (MAFs) > 5% in the Han Chinese population. Two SNPs which meet the above criteria were then genotyped in a case-control cohort comprising 1145 individuals using the TaqMan 5′-exonuclease allelic discrimination assay. Results SNPs rs2486668 and rs545809 were used in this study. Overall genotype and allele distributions of both SNPs in general and stratified genotyping analyses revealed no statistically significant differences between cases and controls. Further logistic regression analyses using different genetic models failed to reveal any evidence that these markers influence risk to NSOFC. Conclusions The variant rs41268753 in GRHL3 increases the risk for cleft palate in European population, but our findings failed to detect the link between two GRHL3 SNPs (rs2486668 and rs545809) and risk to NSOFC in the Han Chinese cohort. Although the present study did not provide any evidence that common functional variants in GRHL3 may contribute to NSOFC etiology in this Chinese population

  20. Lack of Association between Missense Variants in GRHL3 (rs2486668 and rs545809 and Susceptibility to Non-Syndromic Orofacial Clefts in a Han Chinese Population.

    Directory of Open Access Journals (Sweden)

    Miao He

    Full Text Available Grainyhead-like-3 (GRHL3 was recently identified as the second gene that, when mutated, can leads to Van der Woude syndrome, which is characterized by orofacial clefts (OFC and lower lip pits. In addition, a missense variant (rs41268753 in GRHL3 confers risk for non-syndromic cleft palate cases of European ancestry. Together with interferon regulatory factor 6 (IRF6, GRHL3 may be associated with the risk of NSOFC which awaits for being verified across different ethnic populations.The aim of this study was to investigate the possible relationship between common functional variants in GRHL3 and susceptibility to NSOFC, especially cleft palate cases, in a Han Chinese population, one of the ethnic groups with the highest birth prevalence of orofacial clefting.Because the allele frequency for rs41268753 minor alleles was zero in our Chinese population, we selected functional single nucleotide polymorphisms (SNPs spanning GRHL3 with minor allele frequencies (MAFs > 5% in the Han Chinese population. Two SNPs which meet the above criteria were then genotyped in a case-control cohort comprising 1145 individuals using the TaqMan 5'-exonuclease allelic discrimination assay.SNPs rs2486668 and rs545809 were used in this study. Overall genotype and allele distributions of both SNPs in general and stratified genotyping analyses revealed no statistically significant differences between cases and controls. Further logistic regression analyses using different genetic models failed to reveal any evidence that these markers influence risk to NSOFC.The variant rs41268753 in GRHL3 increases the risk for cleft palate in European population, but our findings failed to detect the link between two GRHL3 SNPs (rs2486668 and rs545809 and risk to NSOFC in the Han Chinese cohort. Although the present study did not provide any evidence that common functional variants in GRHL3 may contribute to NSOFC etiology in this Chinese population, further studies with a larger sample

  1. Lack of association between KCNJ11 (rs5219 and ABCC8 (rs757110 polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region

    Directory of Open Access Journals (Sweden)

    Irina Arkadyevna Bondar

    2015-03-01

    Full Text Available AimSulfonylureas (SU are widely used in everyday clinical practice in treatment of patients with type 2 diabetes mellitus (T2DM. There is a considerable variability in SU effects, which may be caused by psychological, social, biological and genetic factors. The aim of the study was to investigate the association between rs5219 KCNJ11 gene and rs757110 ABCC8 gene polymorphism and long-term response to SU-drugs of second and third generation in the Novosibirsk region.Materials and Methods326 patients with type 2 diabetes in the Novosibirsk region were examined. Patients were divided into 2 groups, depending on HbA1c level. The first group included patients with target HbA1c levels on SU monotherapy. The second group included patients who did not reach target HbA1c levels on the highest dose of SU. Genotyping of KCNJ11 (rs5219 and ABCC8 (rs757110 was performed by TaqMan real-time PCR (ICBFM SB RAS, Novosibirsk, Russia.ResultsPatients with type 2 diabetes with a good response to SU-therapy compared to the group of patients with a poor response to SU-therapy were older (65.8±9.1 years vs. 61.6±7.9 years, p<0.01, had later onset of type 2 diabetes (59.7±9.2 years vs. 48.3±9.3 years, p <0.01, shorter duration of type 2 diabetes (6.1±4.8 years vs. 13.2±7.3 years, p<0.01 and weak insulin resistance: fasting insulin 9.7±6.9 mU/ml vs. 13.6±12.7 mU/ml (p<0.05, HOMA-IR 3.1±2.2 vs. 6.2±6.0 (p<0.01, triglycerides 1.76±0.83 mmol/l vs. 2.42±1.97 mmol/l (p <0.01. Statistically significant differences between KCNJ11 (rs5219 and ABCC8 (rs757110 genotypes and response to SU-therapy was not found. The frequency of risk allele T polymorphism rs5219 KCNG11 gene in patients with a good response to SU was 0.38 and in the patients with a poor response to SU -0.38 (χ2=0.02, р=0.89. The frequency of the risk allele G polymorphism rs757110 ABCC8 gene in patients with a good response to SU was 0.40 and in the patients with poor response to SU -0.37 (χ2

  2. Distinct role of the Fas rs1800682 and FasL rs763110 polymorphisms in determining the risk of breast cancer among Han Chinese women

    Directory of Open Access Journals (Sweden)

    Wang M

    2016-07-01

    Full Text Available Meng Wang,1,* Zheng Wang,2,* Xi-Jing Wang,1 Tian-Bo Jin,3 Zhi-Ming Dai,4 Hua-Feng Kang,1 Hai-Tao Guan,1 Xiao-Bin Ma,1 Xing-Han Liu,1 Zhi-Jun Dai1 1Department of Oncology, Second Affiliated Hospital of Xi’an Jiaotong University, 2Department of Medical Oncology, Xi’an Central Hospital, 3National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, 4Department of Anesthesia, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China *These authors contributed equally to this work Background: In recent years, studies have demonstrated that polymorphisms in the promoters of Fas and FasL are significantly associated with breast cancer risk. However, the results of these studies were inconsistent. This case–control study was performed to explore the associations between Fas rs1800682 and FasL rs763110 polymorphisms and breast cancer. Materials and methods: A hospital-based case–control study of 560 Han Chinese females with breast cancer (583 controls was conducted. The MassARRAY system was used to search for a possible association between the disease risk and the two single nucleotide polymorphisms, Fas rs1800682 and FasL rs763110. Statistical analyses were performed using SNPStats software to conduct Pearson’s chi-square tests in five different genetic models. Odds ratios (ORs and 95% confidence intervals (CIs were calculated after adjustment to age and body mass index. PHASE v2.1 software was used to reconstruct all common haplotypes.Results: A statistically significant association was found between Fas rs1800682 and increased breast cancer risk (AG vs AA: OR =1.37, 95% CI =1.06–1.78; AA+AG vs GG: OR =1.32, 95% CI =1.04–1.66, and also it was found that the FasL rs763110 polymorphism may decrease the risk. Stratified analyses demonstrated that the rs763110 polymorphism was associated with lower breast cancer risk among postmenopausal females

  3. Association between CYP19 gene SNP rs2414096 Polymorphism and polycystic ovary syndrome in Chinese women

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    Yi Long

    2009-12-01

    Full Text Available Abstract Background Several studies have reported the association of the SNP rs2414096 in the CYP19 gene with hyperandrogenism, which is one of the clinical manifestations of polycystic ovary syndrome (PCOS. These studies suggest that SNP rs2414096 may be involved in the etiopathogenisis of PCOS. To investigate whetherthe CYP19 gene SNP rs2414096 polymorphism is associated with the susceptibility to PCOS, we designed a case-controlled association study including 684 individuals. Methods A case-controlled association study including 684 individuals (386 PCOS patients and 298 controls was performed to assess the association of SNP rs2414096 with PCOS. Genotyping of SNP rs2414096 was conducted by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP method that was performed on genomic DNA isolated from blood leucocytes. Results were analyzed in respect to clinical test results. Results The genotypic distributions of rs2414096 (GG, AG, AA in the CYP19 gene (GG, AG, AA in women with PCOS (0.363, 0.474, 0.163, respectively were significantly different from that in controls (0.242, 0.500, 0.258, respectively (P = 0.001. E2/T was different between the AA and GG genotypes. Age at menarche (AAM and FSH were also significantly different among the GG, AG, and AA genotypes in women with PCOS (P = 0.0391 and 0.0118, respectively. No differences were observed in body mass index (BMI and other serum hormone concentrations among the three genotypes, either in the PCOS patients or controls. Conclusions Our data suggest that SNP rs2414096 in the CYP19 gene is associated with susceptibility to PCOS.

  4. Foxp3 promoter polymorphism (rs3761548) in breast cancer progression: a study from India.

    Science.gov (United States)

    Jahan, Parveen; Ramachander, V R Vinish; Maruthi, G; Nalini, S; Latha, K Prasanna; Murthy, T S R

    2014-04-01

    Breast cancer is the most common female neoplasm that drives the transformation of normal mammary epithelial cells into highly malignant derivatives. Forkhead Box Protein3 (Foxp3), a tumor suppressor/immunomodulatory gene, which controls the function of Treg cells and oncogenes is down regulated in breast cancer. The main aim of the present study is to evaluate the potential influence of Foxp3-3279 C>A polymorphism (rs3761548) and -2383 C>T polymorphism (rs3761549) in 202 breast cancer patients and 130 normal healthy women of Indian origin. The genotypes were determined using ARMS-PCR for rs3761548 and PCR-RFLP method for rs3761549 using specific primers. The results revealed lack of association of these two polymorphisms with breast cancer susceptibility. However, with respect to AA genotype of rs3761548, we found highly significant association with the advanced stage (T3-4) of the tumor (OR = 3.90; 95% confidence interval (CI) = 1.56-9.70; p = 0.03). Stratified data also revealed an association of homozygous mutant genotype with advanced stage of tumor in premenopausal women (OR = 4.56; 95% CI = 1.07-19.38; p = 0.04) with disease duration of <6 months (OR =  .10; 95% CI = 1.80-20.50; p = 0.002) suggestive of modulating effect of rs3761548 in tumor progression. We conclude that Foxp3 rs37161548 has a potential to be a polymorphic marker for tumor progression in premenopausal breast cancer patients in Indian women. PMID:24338714

  5. Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer.

    Science.gov (United States)

    Ou, Jingxing; Vijayasarathy, Camasamudram; Ziccardi, Lucia; Chen, Shan; Zeng, Yong; Marangoni, Dario; Pope, Jodie G; Bush, Ronald A; Wu, Zhijian; Li, Wei; Sieving, Paul A

    2015-07-01

    Strategies aimed at invoking synaptic plasticity have therapeutic potential for several neurological conditions. The human retinal synaptic disease X-linked retinoschisis (XLRS) is characterized by impaired visual signal transmission through the retina and progressive visual acuity loss, and mice lacking retinoschisin (RS1) recapitulate human disease. Here, we demonstrate that restoration of RS1 via retina-specific delivery of adeno-associated virus type 8-RS1 (AAV8-RS1) vector rescues molecular pathology at the photoreceptor-depolarizing bipolar cell (photoreceptor-DBC) synapse and restores function in adult Rs1-KO animals. Initial development of the photoreceptor-DBC synapse was normal in the Rs1-KO retina; however, the metabotropic glutamate receptor 6/transient receptor potential melastatin subfamily M member 1-signaling (mGluR6/TRPM1-signaling) cascade was not properly maintained. Specifically, the TRPM1 channel and G proteins Gαo, Gβ5, and RGS11 were progressively lost from postsynaptic DBC dendritic tips, whereas the mGluR6 receptor and RGS7 maintained proper synaptic position. This postsynaptic disruption differed from other murine night-blindness models with an electronegative electroretinogram response, which is also characteristic of murine and human XLRS disease. Upon AAV8-RS1 gene transfer to the retina of adult XLRS mice, TRPM1 and the signaling molecules returned to their proper dendritic tip location, and the DBC resting membrane potential was restored. These findings provide insight into the molecular plasticity of a critical synapse in the visual system and demonstrate potential therapeutic avenues for some diseases involving synaptic pathology. PMID:26098217

  6. DeAnnIso: a tool for online detection and annotation of isomiRs from small RNA sequencing data.

    Science.gov (United States)

    Zhang, Yuanwei; Zang, Qiguang; Zhang, Huan; Ban, Rongjun; Yang, Yifan; Iqbal, Furhan; Li, Ao; Shi, Qinghua

    2016-07-01

    Small RNA (sRNA) Sequencing technology has revealed that microRNAs (miRNAs) are capable of exhibiting frequent variations from their canonical sequences, generating multiple variants: the isoforms of miRNAs (isomiRs). However, integrated tool to precisely detect and systematically annotate isomiRs from sRNA sequencing data is still in great demand. Here, we present an online tool, DeAnnIso (Detection and Annotation of IsomiRs from sRNA sequencing data). DeAnnIso can detect all the isomiRs in an uploaded sample, and can extract the differentially expressing isomiRs from paired or multiple samples. Once the isomiRs detection is accomplished, detailed annotation information, including isomiRs expression, isomiRs classification, SNPs in miRNAs and tissue specific isomiR expression are provided to users. Furthermore, DeAnnIso provides a comprehensive module of target analysis and enrichment analysis for the selected isomiRs. Taken together, DeAnnIso is convenient for users to screen for isomiRs of their interest and useful for further functional studies. The server is implemented in PHP + Perl + R and available to all users for free at: http://mcg.ustc.edu.cn/bsc/deanniso/ and http://mcg2.ustc.edu.cn/bsc/deanniso/. PMID:27179030

  7. SISTEM MONITORING LAYAR KOMPUTER SECARA REMOTE MENGGUNAKAN JARINGAN MULTIDROP RS 485

    Directory of Open Access Journals (Sweden)

    Irwan Kristanto

    1999-01-01

    Full Text Available Serial communication is commonly used in PC interface, but serial communication that is commonly used is RS-232 which only could communicate in one to one scheme. This paper will explain a software using the RS-485 interface that can communicate in one to many scheme using a multidrop network system. The server will monitor slave computer, so from the master computer we will be able to see what kind of application is being done in the slave computer. Software has been designed under Windows environtment (32 bit using Delphi 3.0 from Borland International, Inc Software. There are two kinds of software : master and slave. The master software will control the computer we want to monitor, while the slave software will send the monitor picture to the master. The system hardware uses 3 RS 232 to RS 485 converter installed at the 3 PCs, one converter is used by master, and 2 converters are used by slave computers. Testing of picture compression, picture transmission with varying transmission speed have been done in this experiment. Abstract in Bahasa Indonesia : Komunikasi serial banyak sekali digunakan dalam interface PC namun serial yang biasa dipakai adalah RS-232 yang hanya dapat berhubungan secara one to one. Dalam paper ini dibuat software menggunakan sistem RS-485 yang dapat berhubungan secara one to many menggunakan sistem multidrop network. Aplikasinya adalah monitoring komputer, jadi dalam sebuah komputer dapat melihat apa yang sedang dikerjakan oleh komputer lain dengan melihat layar monitor komputer tersebut. Software dibuat berbasis Windows (32 bit dengan bantuan Delphi 3.0 dari Borland International, Inc Software. Software terdiri dari dua yaitu master sebagai pengontrol untuk melihat komputer lain sedangkan slave sebagai pengirim gambar pada komputer yang dimonitor dan bersifat resident dan aktif. Hardware yang digunakan adalah 3 buah RS 232 to RS 485 Converter yang dipasang pada 3 buah PC dimana sebuah PC digunakan untuk master dan 2

  8. Relationship between single nucleotide polymorphism in Smad-interacting protein-1 gene (rs41292293 and rs34961586) and Hirschsprung's disease%SIP1单核苷酸多态性rs41292293和rs34961586与先天性巨结肠的关系

    Institute of Scientific and Technical Information of China (English)

    高红; 张娟; 吕良英; 张志波; 王维林

    2009-01-01

    Objective To investigate the relationship between single nucleotide polymorphisms (SNPs) in Smad-interacting protein-1 (SIP1) (rs41292293 and rs34961586) and Hirschsprung's dis-ease (HD). Methods The genotypes of SIP1 gene SNPs were detected in 180 patients with HD (HD group) and 180 healthy blood donors (control group). DNA was extracted with standard methods. Polymerase chain reaction (PCR) was applied to detect exon5-rs41292293 and exon6-rs4961586 of SIP1. Subsequently, the PCR products were digested with restrictive endonuclease and sequenced by the direct sequencing method. The frequencies of allele and genotypes in both groups were analyzed with Chi-square test. Results Significant difference was noted in the frequencies of the allele (A, G) and genotypes (GA, GG) in SIP1 gene rs41292293 between the HI) group and control group (P< 0. 05). Polymorphism of AG was noted in patients with HD. The genotypic frequencies of GA, AA and GG in the control group and HD group were 48. 89% vs 37. 78%, 35.00% vs 49. 44%, and 16. 11% vs 12. 78%, respectively. Allele frequencies of A (68. 33%) and G (31.67%) were related with HD (P<0.05). Frequencies of the allele (C, G) and genotypes (GC, GG) in SIP1 gene rs34961586 were related with HD. Polymorphism of CG was noted in the HD group. The genotypic frequencies of GC, GG and CC in the control group and the HD group were 34. 44% vs 46. 11%, 56. 11% vs 39. 44%, and 9. 45% vs 14. 45%, respectively. Allele frequency of G (65.83%) and C (34. 17%) was related to the HD ( P < 0. 05 ). Heterozygosity of rs41292293 was noted in the HD group as follows: CCC→CGA mu-tation at position 268 and TGG→ TGT mutation at position 256.Heterozygosity of rs34961586 was also noted in the HD group: CCA→CAC, TGC→TTC and TGC→ TGG mutation at position 135. Conclusions SIP1 rs41292293 and rs34961586 allelic variation may be closely related to the pathogenesis of HD. This study provides some primary laboratory data for fur-ther study on the

  9. Vector subdivision schemes in (Lp(Rs))r(1 ≤ p ≤∞) spaces

    Institute of Scientific and Technical Information of China (English)

    李松

    2003-01-01

    The purpose of this paper is to investigate the refinement equations of the form ψ(x) = ∑α∈Zs a(α)ψ(Mx - α), x ∈ Rs,where the vector of functions ψ=(ψ1,…,ψr)T is in (Lp(Rs))r, 1≤p≤∞,a(α),α∈Zs,is a finitely supported sequence of r × r matrices called the refinement mask, and M is an s × s integer matrix suchthat lim n→∞ M-n = 0. In order to solve the refinement equation mentioned above, we start with a vectorof compactly supported functions ψ0 ∈ (Lp(Rs))r and use the iteration schemes fn := Qnaψ0,n = 1,2,…,where Qa is the linear operator defined on (Lp(Rs))r given by Qaψ:= ∑α∈Zs a(α)ψ(M·- α),ψ∈ (Lp(Rs))r. This iteration scheme is called a subdivision scheme or cascade algorithm. In this paper, we characterize the Lp-convergence of subdivision schemes in terms of the p-norm joint spectral radius of a finite collection of somelinear operators determined by the sequence a and the set B restricted to a certain invariant subspace, wherethe set B is a complete set of representatives of the distinct cosets of the quotient group Zs/MZs containing 0.

  10. Anthrax toxin receptor 2 gene (ANTXR2) rs4333130 is associated with ankylosing spondylitis.

    Science.gov (United States)

    Ou, Yanjuan

    2015-01-01

    Results of recent published studies on the association between the ANTXR2 rs4333130 polymorphism and the risk of ankylosing spondylitis (AS) have often been conflicting. To make a more precise estimation of the potential relationship, a meta-analysis was performed. We conducted a comprehensive search in the electronic database of PubMed and Embase to retrieve relevant articles. Nine studies including 14,523 cases and 34,421 controls were finally selected in this meta-analysis. ANTXR2 rs4333130 was significantly associated with a decreased risk of AS (OR=0.87; 95% CI, 0.84-0.90; P<0.00001). In the subgroup analysis by race, ANTXR2 rs4333130 was significantly associated with a decreased risk of AS in both Asian (OR=0.80; 95% CI, 0.65-0.99; P=0.04) and Caucasian (OR=0.87; 95% CI, 0.84-0.90; P<0.00001). In the subgroup analysis by HLA-B27 status, HLA-B27 positive individuals with ANTXR2 rs4333130 showed decreased AS risk (OR=0.89; 95% CI, 0.83-0.96; P=0.002). However, HLA-B27 negative individuals with this polymorphism did not showed decreased AS risk (OR=0.96; 95% CI, 0.88-1.06; P=0.44). In conclusion, this meta-analysis suggested a significant association between ANTXR2 rs4333130 polymorphism and AS risk.

  11. Two-Component Signal Transduction System SaeRS Positively Regulates Staphylococcus epidermidis Glucose Metabolism

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    Qiang Lou

    2014-01-01

    Full Text Available Staphylococcus epidermidis, which is a causative pathogen of nosocomial infection, expresses its virulent traits such as biofilm and autolysis regulated by two-component signal transduction system SaeRS. In this study, we performed a proteomic analysis of differences in expression between the S. epidermidis 1457 wild-type and saeRS mutant to identify candidates regulated by saeRS using two-dimensional gel electrophoresis (2-DE combined with matrix-assisted laser desorption/lonization mass spectrometry (MALDI-TOF-MS. Of 55 identified proteins that significantly differed in expression between the two strains, 15 were upregulated and 40 were downregulated. The downregulated proteins included enzymes related to glycolysis and TCA cycle, suggesting that glucose is not properly utilized in S. epidermidis when saeRS was deleted. The study will be helpful for treatment of S. epidermidis infection from the viewpoint of metabolic modulation dependent on two-component signal transduction system SaeRS.

  12. Prostasin gene polymorphism at rs12597511 is associated with severe preeclampsia in Chinese Han women

    Institute of Scientific and Technical Information of China (English)

    Luo Dong; Zhang Yanyan; Bai Yi; Liu Xijing; Gong Yunhui; Zhou Bin; Zhang Lin

    2014-01-01

    Background Preeclampsia,characterized by hypertension and proteinuria,is a multifactorial disease associated with shallow invasion of trophoblast cells and inadequate spiral artery remodeling.Trophoblast and tumor cells have similar invasion mechanism.Prostasin is closely related to tumor development,invasion and metastasis and influences blood pressure through activating epithelial sodium channel.The effect of prostasin on the pathogenesis of preeclampsia remains unclear.This study investigated the association of prostasin gene at rs12597511 with severe preeclampsia.Methods A single nucleotide polymorphism,rs12597511,was tested with polymerase chain reaction and restrictionfragment length polymorphism analyses in 179 severe preeclampsia patients and 222 normal pregnant women.Results The frequencies of TC + CC genotypes were significantly higher in severe preeclampsia group compared with in control group (the adjusted odds ratio was 2.030,95% confidence interval 1.195-3.449,P=0.009).The C allele of rs12597511 was present significantly more often among women with severe preeclampsia (P=0.001).Genotyping analysis showed that the C allele of rs12597511 could confer a risk for severe preeclampsia.Conclusion The higher frequency of C allele of prostasin gene at rs12597511 is associated with severe preeclampsia.

  13. Homoeologous cloning of ω-secalin gene family in a wheat 1BL/1RS translocation

    Institute of Scientific and Technical Information of China (English)

    Jian Fang CHAI; Xu LIU; Ji Zeng JIA

    2005-01-01

    Wheat 1BL/1RS translocations are widely planted in China as well as in most of the wheat producing area in the world for their good qualities of disease resistance and high yield. 1BL/1RS translocations are however poor in bread making,partially caused by a family of small monomeric proteins, ω-secalins, which are encoded by genes on 1RS. Based on published sequence of a rye ω-secalin gene we designed a pair of primers to cover the whole mature protein coding sequence. A major band could be amplified from 1BL/1RS translocations but not from euploid wheat. Using this primer set we conducted PCR amplification by using high fidelity Pfu polymerase on the genomic DNAs and cDNAs purified from a 1BL/1RS translocation Lankao 906. Sequencing analysis indicated that this gene family contains several members of 1150 bp, 1076 bp, 1075 bp, 1052 bp and 1004 bp genes, including two pseudogenes and three active genes. The gene transcripts were differentially expressed in developing seeds.

  14. Anti Pneumococcal Activity of Azithromycin-Eudragit RS100 Nano-Formulations

    Science.gov (United States)

    Adibkia, Khosro; Khorasani, Golrokh; Payab, Shahriar; Lotfipour, Farzaneh

    2016-01-01

    Purpose: Bacterial pneumonia is a common lung infection caused by different types of bacteria. Azithromycin (AZI), an azalide antibiotic, is widely used to manage pneumococcal infections. Studies have shown that antibiotics in nanocarriers may lead to increased antibacterial activity and reduced toxicity. The aim of this work was to valuate in vitro antibacterial performance azithromycin-Eudragit RS100 nano-formulations against Streptococcus pneumoniae and Staphylococcus aureus. Methods: AZI-Eudragit RS100 nanoparticles were prepared via electrospinning technique and the in vitro antibacterial performance against S. pneumoniae and S. aureus were assessed using agar dilution method. Results: Nanofibers in the sizes about 100-300 nm in diameter and micro scale in length and nanobeads in the range of 100-500 nm were achieved. The Minimum Inhibitory Concentrations (MIC) showed an enhancement in the antimicrobial effect of AZI-Eudragit RS100 nanofibers (40 µg/ml) compare to untreated AZI solution (>160 µg/ml) against S. pneumonia. The MIC value for AZI-Eudragit RS100 nanofibers against S. aureus was >128 µg/ml, same as that of the untreated AZI solution. Conclusion: The enhanced efficiency of AZI in nanofibers could be related to the more adsorption opportunity of nanofibers to S. pneumonia capsulated cell wall which provides an antibiotic depot on the bacterial surface compared to S. aureus. AZI-Eudragit RS100 nanofibers with enhanced antimicrobial effect against S. pneumonia can be considered as a candidate for in vivo evaluations in antibiotic therapy of Pneumococcal infections.

  15. Comments on: Association Study between Coronary Artery Disease and rs1333049 and rs10757274 Polymorphisms at 9p21 Locus in South-West Iran

    Directory of Open Access Journals (Sweden)

    Michael H. Preuß

    2016-02-01

    Full Text Available Foroughmand et al. (1 have recently reported association between coronary artery disease (CAD and two well-known single nucleotide polymorphisms (SNPs on chromosome 9p21.3 in subjects from South-West Iran. We doubt the validity of their findings. Genotyping was done using ARMS-PCR for rs1333049 and rs10757274 in their study. When we first looked at the genotype frequencies, we observed a substantial excess of heterozygote subjects for both SNPs. Specifically, the relative excess of heterozygosity (REH (2, a measure for the strength of deviation from Hardy-Weinberg equilibrium (HWE, was approximately 137% for rs1333049 in controls (REH=2.3688, Table 1. In contrast, we did not observe any deviation from HWE in our own studies (3, 4. We additionally conducted a short literature search to identify other studies from Asia, which reported genotype frequencies in controls for rs1333049. These studies are summarized in table 1. None of these studies shows a deviation from HWE in their control groups (all P>0.05. In summary, only the recent study by Foroughmand and colleagues (1 shows a marked deviation from HWE in controls with this deviation observed for both reported SNPs. Possible reasons for deviations from HWE have been summarized, e.g., in Ziegler et al. (2. The most likely cause for such a strong deviation from HWE is genotyping errors, especially because genotyping by ARMS-PCR plus gel electrophoresis is prone to such errors. However, REH could also be caused by population specifics, which has been discussed by Namipashaki et al. (5. In any case, we (2 and others (5 recommend the investigation of HWE in population-based genetic association studies to improve quality and reliability of the research results.

  16. Promoter SNPs rs116896264 and rs73933062 form a distinct haplotype and are associated with galectin-4 overexpression in colorectal cancer.

    Science.gov (United States)

    Helwa, Reham; Ramadan, Mohamed; Abdel-Wahab, Abdel-Hady A; Knappskog, Stian; Bauer, Andrea S

    2016-07-01

    Galectin-4 is a member of the galectin family which consists of 15 galactoside-binding proteins. Previously, galectin-4 has been shown to have a role in cancer progression and metastasis and it is found upregulated in many solid tumours, including colorectal cancer (CRC). Recently, the role in the metastatic process was suggested to be via promoting cancer cells to adhere to blood vascular endothelium. In the present study, the regulatory region of LGALS4 (galectin-4) in seven colon cell lines was investigated with respect to genetic variation that could be linked to expression levels and therefore a tumourigenic effect. Interestingly, qRT-PCR and sequencing results revealed that galectin-4 upregulation is associated with SNPs rs116896264 and rs73933062. By use of luciferase reporter- and pull-down assays, we confirmed the association between the gene upregulation and the two SNPs. Also, using pull-down assay followed by mass spectrometry, we found that the presence rs116896264 and rs73933062 is changing transcription factors binding sites. In order to assess the frequencies of the two SNPs among colon cancer patients and healthy individuals, we genotyped 75 colon cancer patients, 12 patients with adenomatous polyposis and 17 patients with ulcerative colitis and we performed data mining in the 1000 genomes databank. We found the two SNPs co-occuring in 21% of 75 CRC patients, 0 out of 12 patients of adenomatous polyposis, and 6 out of 17 patients (35%) with ulcerative colitis. Both in the patient samples and in the 1000 genomes project, the two SNPs were found to co-occur whenever present (D' = 1). PMID:26681582

  17. Demanda hídrica e coeficientes de cultura (Kc para macieiras em Vacaria, RS Water requirement and crop coefficients (Kc for apple trees in Vacaria, RS, Brazil

    Directory of Open Access Journals (Sweden)

    Marco Antônio Fonseca Conceição

    2011-03-01

    Full Text Available O objetivo do presente trabalho foi determinar a demanda hídrica e os coeficientes de cultura (Kc para macieiras cultivadas na região de Vacaria, RS. O trabalho foi desenvolvido na Estação Experimental de Fruticultura Temperada (EEFT da Embrapa Uva e Vinho, localizada em Vacaria, RS, em plantas da cultivar 'Royal Gala' (Malus domestica sobre porta-enxerto M9. Foram determinados os valores do potencial matricial da água no solo, empregando-se tensiômetros de punção. Com base nesses valores, determinou-se a umidade volumétrica e o balanço hídrico mensal. O consumo hídrico da cultura variou entre 0,3mm dia-1 a 4,5mm dia-1, com média de 1,9mm dia-1. O coeficiente da cultura (Kc apresentou tendência quadrática, variando entre 0,19 e 0,88, com média igual a 0,58.The objective of this study was to determine the water requirement and the crop coefficients (Kc values for apple trees cultivated in Vacaria, RS. The study was conducted at the Experimental Station of Temperate Fruits (EEFT of Embrapa Grape and Wine, located in Vacaria, RS, in plants of the cultivar 'Royal Gala' (Malus domestica on the rootstock M9. The soil water matric potential values, that were determined employing tensiometers, were used to obtain the soil moisture and the monthly soil water balance. The water consumption of the culture ranged from 0.3mm day-1 to 4.5mm day-1, with an average of 1.9mm day-1. The crop coefficient (Kc presented a quadratic trend, ranging between 0.19 and 0.88, with mean value of 0.58.

  18. The RNA-binding protein HOS5 and serine/arginine-rich proteins RS40 and RS41 participate in miRNA biogenesis in Arabidopsis

    KAUST Repository

    Chen, Tao

    2015-07-30

    MicroRNAs are a class of small regulatory RNAs that are generated from primary miRNA (pri-miRNA) transcripts with a stem-loop structure. Accuracy of the processing of pri-miRNA into mature miRNA in plants can be enhanced by SERRATE (SE) and HYPONASTIC LEAVES 1 (HYL1). HYL1 activity is regulated by the FIERY2 (FRY2)/RNA polymerase II C-terminal domain phosphatase-like 1 (CPL1). Here, we discover that HIGH OSMOTIC STRESS GENE EXPRESSION 5 (HOS5) and two serine/arginine-rich splicing factors RS40 and RS41, previously shown to be involved in pre-mRNA splicing, affect the biogenesis of a subset of miRNA. These proteins are required for correct miRNA strand selection and the maintenance of miRNA levels. FRY2 dephosphorylates HOS5 whose phosphorylation status affects its subnuclear localization. HOS5 and the RS proteins bind both intronless and intron-containing pri-miRNAs. Importantly, all of these splicing-related factors directly interact with both HYL1 and SE in nuclear splicing speckles. Our results indicate that these splicing factors are directly involved in the biogenesis of a group of miRNA.

  19. The RNA-binding protein HOS5 and serine/arginine-rich proteins RS40 and RS41 participate in miRNA biogenesis in Arabidopsis.

    Science.gov (United States)

    Chen, Tao; Cui, Peng; Xiong, Liming

    2015-09-30

    MicroRNAs are a class of small regulatory RNAs that are generated from primary miRNA (pri-miRNA) transcripts with a stem-loop structure. Accuracy of the processing of pri-miRNA into mature miRNA in plants can be enhanced by SERRATE (SE) and HYPONASTIC LEAVES 1 (HYL1). HYL1 activity is regulated by the FIERY2 (FRY2)/RNA polymerase II C-terminal domain phosphatase-like 1 (CPL1). Here, we discover that HIGH OSMOTIC STRESS GENE EXPRESSION 5 (HOS5) and two serine/arginine-rich splicing factors RS40 and RS41, previously shown to be involved in pre-mRNA splicing, affect the biogenesis of a subset of miRNA. These proteins are required for correct miRNA strand selection and the maintenance of miRNA levels. FRY2 dephosphorylates HOS5 whose phosphorylation status affects its subnuclear localization. HOS5 and the RS proteins bind both intronless and intron-containing pri-miRNAs. Importantly, all of these splicing-related factors directly interact with both HYL1 and SE in nuclear splicing speckles. Our results indicate that these splicing factors are directly involved in the biogenesis of a group of miRNA.

  20. Genetic Algorithm to Make Persistent Security and Quality of Image in Steganography from RS Analysis

    CERN Document Server

    Nair, T R Gopalakrishnan; S, Manas

    2012-01-01

    Retention of secrecy is one of the significant features during communication activity. Steganography is one of the popular methods to achieve secret communication between sender and receiver by hiding message in any form of cover media such as an audio, video, text, images etc. Least significant bit encoding is the simplest encoding method used by many steganography programs to hide secret message in 24bit, 8bit colour images and grayscale images. Steganalysis is a method of detecting secret message hidden in a cover media using steganography. RS steganalysis is one of the most reliable steganalysis which performs statistical analysis of the pixels to successfully detect the hidden message in an image. However, existing steganography method protects the information against RS steganalysis in grey scale images. This paper presents a steganography method using genetic algorithm to protect against the RS attack in colour images. Stego image is divided into number of blocks. Subsequently, with the implementation ...

  1. rs10865331 associated with susceptibility and disease severity of ankylosing spondylitis in a Taiwanese population.

    Directory of Open Access Journals (Sweden)

    Ya-Feng Wen

    Full Text Available Ankylosing spondylitis (AS is a highly familial rheumatic disorder and is considered as a chronic inflammatory disease. Genetic factors are involved in the pathogenesis of AS. To identify genes which render people susceptible to AS in a Taiwanese population, we selected six single-nucleotide polymorphisms (SNPs from previous genome-wide association studies (GWASs which were associated with AS in European descendants and Han Chinese. To assess whether the six SNPs contributed to AS susceptibility and severity in Taiwanese population, 475 AS patients fulfilling the modified New York Criteria and 527 healthy subjects were recruited. We found that rs10865331 was significantly associated with AS susceptibility and with Bath AS Function Index (BASFI. The AA and AG genotypes of rs10865331 were also significantly associated with a higher erythrocyte sedimentation rate. Our findings provided evidence that rs10865331 is associated AS susceptibility and with disease activity (BASFI in a Taiwanese population.

  2. Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes

    DEFF Research Database (Denmark)

    Hansen, Tue H; Vestergaard, Henrik; Jørgensen, Torben;

    2015-01-01

    Background: The variant rs11085226 (G) within the gene encoding polypyrimidine tract binding protein 1 (PTBP1) was reported to associate with reduced insulin release determined by an oral glucose tolerance test (OGTT) as well as an intravenous glucose tolerance test (IVGTT). The aim of the present...... study was to validate the association of the rs11085226 G-allele of PTBP1 with previously investigated OGTT- and IVGTT-derived diabetes-related metabolic quantitative phenotypes, to conduct exploratory analyses of additional measures of beta-cell function, and to further investigate a potential.......024; P=0.01) assuming a dominant model of inheritance, but failed to replicate a previously reported association with area under the curve (AUC) for insulin. Case control analysis did not show an association of the PTBP1 rs11085226 variant with type 2 diabetes. Conclusions: Despite failure to replicate...

  3. Psychometric Properties of the Parent and Teacher ADHD Rating Scale (ADHD-RS)

    DEFF Research Database (Denmark)

    Makransky, Guido; Bilenberg, Niels

    2014-01-01

    inattention and hyperactivity/impulsivity subscales and is one of the most frequently used scales in treatment evaluation of children with ADHD. An extended version, mADHD-RS, also includes an oppositional defiant disorder subscale. The partial credit Rasch model, which is based on item response theory......, was used to test the psychometric properties of this scale in a sample of 566 Danish school children between 6 and 16 years of age. The results indicated that parents and teachers had different frames of reference when rating symptoms in the mADHD-RS. There was support for the unidimensionality...... of the three subscales when parent and teacher ratings were analyzed independently. Nonetheless, evidence for differential item functioning was found across gender and age for specific items within each of the subscales. The findings expand existing psychometric information about the mADHD-RS and support its...

  4. P-bRS: A Physarum-Based Routing Scheme for Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Mingchuan Zhang

    2014-01-01

    Full Text Available Routing in wireless sensor networks (WSNs is an extremely challenging issue due to the features of WSNs. Inspired by the large and single-celled amoeboid organism, slime mold Physarum polycephalum, we establish a novel selecting next hop model (SNH. Based on this model, we present a novel Physarum-based routing scheme (P-bRS for WSNs to balance routing efficiency and energy equilibrium. In P-bRS, a sensor node can choose the proper next hop by using SNH which comprehensively considers the distance, energy residue, and location of the next hop. The simulation results show how P-bRS can achieve the effective trade-off between routing efficiency and energy equilibrium compared to two famous algorithms.

  5. The SaeRS Two-Component System of Staphylococcus aureus

    Science.gov (United States)

    Liu, Qian; Yeo, Won-Sik; Bae, Taeok

    2016-01-01

    In the Gram-positive pathogenic bacterium Staphylococcus aureus, the SaeRS two-component system (TCS) plays a major role in controlling the production of over 20 virulence factors including hemolysins, leukocidins, superantigens, surface proteins, and proteases. The SaeRS TCS is composed of the sensor histidine kinase SaeS, response regulator SaeR, and two auxiliary proteins SaeP and SaeQ. Since its discovery in 1994, the sae locus has been studied extensively, and its contributions to staphylococcal virulence and pathogenesis have been well documented and understood; however, the molecular mechanism by which the SaeRS TCS receives and processes cognate signals is not. In this article, therefore, we review the literature focusing on the signaling mechanism and its interaction with other global regulators. PMID:27706107

  6. P-bRS: a physarum-based routing scheme for wireless sensor networks.

    Science.gov (United States)

    Zhang, Mingchuan; Wei, Wangyang; Zheng, Ruijuan; Wu, Qingtao

    2014-01-01

    Routing in wireless sensor networks (WSNs) is an extremely challenging issue due to the features of WSNs. Inspired by the large and single-celled amoeboid organism, slime mold Physarum polycephalum, we establish a novel selecting next hop model (SNH). Based on this model, we present a novel Physarum-based routing scheme (P-bRS) for WSNs to balance routing efficiency and energy equilibrium. In P-bRS, a sensor node can choose the proper next hop by using SNH which comprehensively considers the distance, energy residue, and location of the next hop. The simulation results show how P-bRS can achieve the effective trade-off between routing efficiency and energy equilibrium compared to two famous algorithms. PMID:24672326

  7. Polymorphism of MDM2 promoter 309 (rs 2279744) and the risk of PCOS.

    Science.gov (United States)

    Chan, Ying; Jiang, Hongguo; Yang, Xiaoling; Li, Dongya; Ma, Lan; Luo, Ying; Tang, Wenru

    2016-01-01

    This study aimed at evaluating possible association between MDM2 SNP309 polymorphism (rs 2279744) and polycystic ovary syndrome (PCOS). One hundred and twenty-five women with PCOS and two hundred and fifty women without PCOS were collected from the department of reproductive medicine of college hospital in this case-control study. Peripheral blood samples were collected from all participants and DNA was extracted, MDM2 SNP309 polymorphism (rs 2279744) was determined from the 125 cases and 250 controls. Women were grouped into PCOS (n = 125) group and control group (n = 250). Odds ratios (OR) and 95% confidence intervals (CI) were used to evaluate the association between MDM2 SNP309 polymorphism (rs 2279744) and PCOS. The distribution of T allele was significant higher in PCOS cases than controls. MDM2 SNP 309 T allele is associated with PCOS.

  8. Working in partnership to advance the 3Rs in toxicity testing

    International Nuclear Information System (INIS)

    Toxicological assessment of pharmaceutical and non-pharmaceutical chemicals is a regulatory requirement to ensure all compounds likely to be exposed to humans or the environment are safe. These studies rely on the use of large numbers of animals and involve a number of assumptions and extrapolations that remain controversial in assuring consumer safety. The UK's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) has taken a collaborative approach to identify opportunities for implementation of the 3Rs principles (Replacement, Reduction and Refinement) to drive innovation and support animal welfare in toxicity testing. This review highlights the mechanisms by which the NC3Rs is working with the pharmaceutical and chemical industries and regulatory authorities to achieve these goals.

  9. TERT Polymorphism rs2853669 Influences on Lung Cancer Risk in the Korean Population.

    Science.gov (United States)

    Yoo, Seung Soo; Do, Sook Kyung; Choi, Jin Eun; Lee, Shin Yup; Lee, Jaehee; Cha, Seung Ick; Kim, Chang Ho; Park, Jae Yong

    2015-10-01

    Short telomeres are known as one of the risk factors for human cancers. The present study was conducted to evaluate the association between 6 polymorphisms, which were related with short telomere length in the Korean population, and lung cancer risk using 1,100 cases and 1,096 controls. Among the 6 polymorphisms, TERT rs2853669 was significantly associated with increased lung cancer risk under a recessive model (odds ratio [OR]=1.38, 95% confidence interval [CI]=1.05-1.81, P=0.02). The effect of rs2853669 on lung cancer risk was significant in younger individuals (OR=1.73, 95% CI=1.18-2.54, P=0.005) and adenocarcinoma (OR=1.50, 95% CI=1.07-2.07, P=0.02). Our results suggest that a common functional promoter polymorphism, TERT rs2853669, may influence both telomere length and lung cancer risk in the Korean population.

  10. Is the COL5A1 rs12722 Gene Polymorphism Associated with Running Economy?

    Science.gov (United States)

    Bertuzzi, Rômulo; Pasqua, Leonardo A.; Bueno, Salomão; Lima-Silva, Adriano Eduardo; Matsuda, Monique; Marquezini, Monica; Saldiva, Paulo H.

    2014-01-01

    The COL5A1 rs12722 polymorphism is considered to be a novel genetic marker for endurance running performance. It has been postulated that COL5A1 rs12722 may influence the elasticity of tendons and the energetic cost of running. To date, there are no experimental data in the literature supporting the relationship between range of motion, running economy, and the COL5A1 rs12722 gene polymorphism. Therefore, the main purpose of the current study was to analyze the influence of the COL5A1rs12722 polymorphism on running economy and range of motion. One hundred and fifty (n = 150) physically active young men performed the following tests: a) a maximal incremental treadmill test, b) two constant-speed running tests (10 km•h−1 and 12 km•h−1) to determine the running economy, and c) a sit-and-reach test to determine the range of motion. All of the subjects were genotyped for the COL5A1 rs12722 single-nucleotide polymorphism. The genotype frequencies were TT = 27.9%, CT = 55.8%, and CC = 16.3%. There were no significant differences between COL5A1 genotypes for running economy measured at 10 km•h−1 (p = 0.232) and 12 km•h−1 (p = 0.259). Similarly, there were no significant differences between COL5A1 genotypes for range of motion (p = 0.337). These findings suggest that the previous relationship reported between COL5A1 rs12722 genotypes and running endurance performance might not be mediated by the energetic cost of running. PMID:25188268

  11. SHBG gene polymorphism (rs1799941 associates with metabolic syndrome in children and adolescents.

    Directory of Open Access Journals (Sweden)

    Marquitta J White

    Full Text Available Metabolic syndrome (MetS is a complex disorder characterized by coexistence of several cardiometabolic (CM factors, i.e. hyperlipidemia, obesity, high blood pressure and insulin resistance. The presence of MetS is strongly associated with increased risk of cardiovascular disease (CVD. The syndrome was originally defined as an adult disorder, but MetS has become increasingly recognized in children and adolescents.Genetic variants influence biological components common to the CM factors that comprise MetS. We investigated single locus associations between six single nucleotide polymorphisms (SNPs, previously shown to modulate lipid or sex hormone binding globulin (SHBG levels, with MetS in a Turkish pediatric cohort (37 cases, 323 controls.Logistic regression analysis revealed a significant association between rs1799941, located in SHBG, and MetS (OR = 3.09, p-value = 0.006. The association with MetS remained after sequential adjustment for each CM factor included in the syndrome definition, indicating that the identified association is not being driven by any single trait. A relationship between rs1799941 and SHBG levels, was also discovered, but it was dependent on MetS status. In control subjects, the A allele of rs1799941 associated with a significant increase in SHBG levels (p = 0.012, while in cases there was no association between rs1799941 and SHBG levels (p = 0.963.The significant association between rs1799941 and MetS in children is not contingent on any single CM trait. Additionally, the presence of MetS may abrogate effect of rs1799941 polymorphism on SHBG levels in children.

  12. Association between Tourette Syndrome and the Dopamine D3 Receptor Gene Rs6280

    Institute of Scientific and Technical Information of China (English)

    Fan He; Yi Zheng; Huan-Huan Huang; Yu-Hang Cheng; Chuan-Yue Wang

    2015-01-01

    Background:Tourette syndrome (TS) is a complex,heterozygous genetic disorder.The number of molecular genetic studies have investigated several candidate genes,particularly those implicated in the dopamine system.The dopamine D3 receptor (DRD3) gene has been considered as a candidate gene in TS.There was not any report about the association study of TS and DRD3 gene in Han Chinese population.We combined a case-control genetic association analysis and nuclear pedigrees transmission disequilibrium test (TDT) analysis to investigate the association between DRD3 gene rs6280 single nucleotide polymorphisms (SNPs) and TS in a Han Chinese population.Methods:A total of 160 TS patients was diagnosed by the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition.The DRD3 gene rs6280 SNPs were genotyped by TaqMan SNP genotyping assay technique in all subjects.We used a case-control genetic association analysis to compare the difference in genotype and allele frequencies between 160 TS patients and 90 healthy controls.At the same time,we used TDT analysis to identify the DRD3 gene rs6280 transmission disequilibrium among 10l nuclear pedigrees.Results:The genotype and allele frequency of DRD3 gene rs6280 SNPs had no statistical difference between control group (90) and TS group (160) (x2 =3.647,P =0.161; x2 =0.643,P =0.423) using Chi-squared test.At the basis of the 101 nuclear pedigrees,TDT analysis showed no transmission disequilibrium ofDRD3 gene rs6280 SNPs (x2 =0; P =1).Conclusions:Our findings provide no evidence for an association between DRD3 gene rs6280 and TS in the Han Chinese population.

  13. Is the COL5A1 rs12722 gene polymorphism associated with running economy?

    Directory of Open Access Journals (Sweden)

    Rômulo Bertuzzi

    Full Text Available The COL5A1 rs12722 polymorphism is considered to be a novel genetic marker for endurance running performance. It has been postulated that COL5A1 rs12722 may influence the elasticity of tendons and the energetic cost of running. To date, there are no experimental data in the literature supporting the relationship between range of motion, running economy, and the COL5A1 rs12722 gene polymorphism. Therefore, the main purpose of the current study was to analyze the influence of the COL5A1rs12722 polymorphism on running economy and range of motion. One hundred and fifty (n = 150 physically active young men performed the following tests: a a maximal incremental treadmill test, b two constant-speed running tests (10 km · h(-1 and 12 km · h(-1 to determine the running economy, and c a sit-and-reach test to determine the range of motion. All of the subjects were genotyped for the COL5A1 rs12722 single-nucleotide polymorphism. The genotype frequencies were TT = 27.9%, CT = 55.8%, and CC = 16.3%. There were no significant differences between COL5A1 genotypes for running economy measured at 10 km · h(-1 (p = 0.232 and 12 km · h(-1 (p = 0.259. Similarly, there were no significant differences between COL5A1 genotypes for range of motion (p = 0.337. These findings suggest that the previous relationship reported between COL5A1 rs12722 genotypes and running endurance performance might not be mediated by the energetic cost of running.

  14. Nitrofurantoin, phenazopyridine, and the superoxide-response regulon soxRS of Escherichia coli.

    Science.gov (United States)

    Amábile-Cuevas, Carlos F; Arredondo-García, José Luis

    2013-12-01

    Nitrofurantoin and phenazopyridine are two drugs commonly used against urinary tract infections. Both compounds exert oxidative damage in patients deficient in glucose-6-phosphate dehydrogenase. This study was done to assess the interactions of these drugs with the soxRS regulon of Escherichia coli, a superoxide-defense system (that includes a nitroreductase that yields the active metabolite of nitrofurantoin) involved in antibiotic multi-resistance. The effects of either nitrofurantoin or phenazopyridine, upon strains with different soxRS genotypes, were measured as minimum inhibitory concentrations (MICs) and growth curves. Also, the ability of these drugs to induce the expression of a soxS'::lacZ gene fusion was assessed. The effect of antibiotics in the presence of phenazopyridine, paraquat (a known soxRS inducer), or an efflux inhibitor, was measured using the disk diffusion method. A strain constitutively expressing the soxRS regulon was slightly more susceptible to nitrofurantoin, and more resistant to phenazopyridine, compared to wild-type and soxRS-deleted strains, during early treatment, but 24-h MICs were the same (8 mg/l nitrofurantoin, 1,000 mg/l phenazopyridine) for all strains. Both compounds were capable of inducing the expression of a soxS'::lacZ fusion, but less than paraquat. Subinhibitory concentrations of phenazopyridine increased the antimicrobial effect of ampicillin, chloramphenicol, tetracycline, and nitrofurantoin. The induction or constitutive expression of the soxRS regulon seems to be a disadvantage for E. coli during nitrofurantoin exposure; but might be an advantage during phenazopyridine exposure, indicating that the latter compound could act as a selective pressure for mutations related to virulence and antibiotic multi-resistance. PMID:23793794

  15. Propagation of ELF Radiation from RS-LC System and Red Sprites in Earth-Ionosphere Waveguide

    Directory of Open Access Journals (Sweden)

    Manoj Kumar Paras

    2012-08-01

    Full Text Available In this paper, two different mechanisms return stroke-lateral corona (RS-LC system and red sprites which excite Earth-ionosphere waveguide have been discussed. The electric and magnetic fields from RS-LC system and red spites in the Earth-ionosphere waveguide have been calculated. It has been found that red sprites contribute to the Schumann resonances (SR greatly as compared to the RS-LC system.

  16. OpenRS-Cloud:A remote sensing image processing platform based on cloud computing environment

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    This paper explores the use of cloud computing for remote sensing image processing.The main contribution of our work is to develop a remote sensing image processing platform based on cloud computing technology(OpenRS-Cloud).This paper focuses on enabling methodical investigations into the development pattern,computational model,data management and service model exploring this novel distributed computing model.The experimental INSAR processing flow is implemented to verify the efficiency and feasibility of OpenRS-Cloud platform.The results show that cloud computing is well suited for computationally-intensive and data-intensive remote sensing services.

  17. Microchip选择RS Components作为产品样本供应商

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    全球知名微控制器半导体供货商Microchip与RS展开合作,向在www.microchip.com网站上索取样本的客户优先推荐RS产品。当欧洲和亚洲的电子设计工程师希望购买其产品时,Microchip会为顾客提供快速通道。直接链接到RS Components网站www.rs-components.com下订单。

  18. Developing RESTful services with JAX-RS 2.0, WebSockets, and JSON

    CERN Document Server

    Kalali, Masoud

    2013-01-01

    Written as an easy and practical guide, this book is a crash course on using JAX-RS 2.0, JSON, and WebSockets to develop RESTful services.Getting Started with Developing RESTful Web Services using JAX-RS 2.0, JSON, and WebSockets is a perfect reading source for application developers who are familiar with Java EE and are keen to understand the new HTML5-related functionality introduced in Java EE 7 to improve productivity. To take full advantage of this book, you need to be familiar with Java EE and have some basic understanding of using the GlassFish application server.

  19. SNP rs1511412 in FOXL2 gene as a risk factor for keloid by meta analysis

    OpenAIRE

    Lu, Wensheng; Zheng, Xiaodong; Liu, Shengli; Ding, Maoqian; Xie, Jian; Yao, Xiuhua; Zhang, Lanfang; Hu, Bai

    2015-01-01

    Objective: Determine whether SNP rs1511412 is associated with keloid. Design and methods: One large-scale GWAS identified association between SNP rs1511412 in the FOXL2 gene and keloid disease in the Japanese population. However, researchers didn’t observe significant association for keloid in Chinese Han population (PBonferroni>0.05). It’s probable that the frequency of this variant in Chinese Han population was relatively low and the sample size was not very large in this study (power =45.5...

  20. Performance Analysis of DRA Based OFDM Data Transmission With Respect to Novel High Speed RS Decoding

    Directory of Open Access Journals (Sweden)

    Dr. S. V. A. V Prasad

    2015-02-01

    Full Text Available In this paper, we have analyzed the performance characteristics of OFDM data transmission with regard to a new high speed RS decoding algorithm. The various characteristics identified are mainly speed and accuracy of the transmission irrespective of channel behaviour. We consider two cases viz. data transmission without error control and data transmission with error control. Each of these cases are duly analyzed and it is proven that high speed RS decoding algorithms can actually benefit OFDM data transmission for advanced communication systems only if implemented at the hardware (VLSI level because of significant processing overhead involved in software based implementation even though the algorithm may have lower computational complexity.

  1. Association between the rs2910164 Polymorphism in Pre-Mir-146a Sequence and Thyroid Carcinogenesis

    OpenAIRE

    Wei, Wen-Jun; Wang, Yu-Long; Li, Duan-Shu; Wang, Yu; Wang, Xiao-Feng; Zhu, Yong-Xue; Yang, Ya-Jun; Wang, Zhuo-Ying; Ma, Yan-yun; Yi WU; Jin, Li; Ji, Qing-Hai; Wang, Jiu-Cun

    2013-01-01

    Background Rs2910164, a Single nucleotide polymorphism (SNP) located in the precursor microRNA sequence of miR-146a, is the only MicroRNA sequence SNP studied in papillary thyroid cancer (PTC). Association studies had been performed in US and UK-Northern European populations, but results were inconsistence. This study evaluated the association between rs2910164 and the risk of PTC as well as benign thyroid tumor (BN), and examined the clinicopathological characteristics of PTC and BN for diff...

  2. An Integrated GIS/RS Approach for Soil Erosion Assessment and Modeling in Syrian Coastal Soils

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    An integrated remote sensing (RS) and geographic information system (GIS) technique was employed to characterize the spatial distribution of the risk of soil erosion by water on Latakia district,Syria.The universal soil loss equation (USLE) was used to calculate the annual soil loss rates for Latakia soils.Mainly,remote sensing data,soil survey,land use inventory,elevation data and climatic atlases are used as resource data sets to generate USLE factor values.The results revealed that integration of GIS/RS with USLE was a practical and effective approach for monitoring soil erosion over large areas.

  3. Implementation of RS-485 Communication between PLC and PC of Distributed Control System Based on VB

    Science.gov (United States)

    Lian Zhang, Chuan; Da Huang, Zhi; Qing Zhou, Gui; Chong, Kil To

    2015-05-01

    This paper focuses on achieving RS-485 communication between programmable logical controller (PLC) and PC based on visual basic 6.0 (VB6.0) on an experimental automatic production line. Mitsubishi FX2N PLCs and a PC are chosen as slave stations and main station, respectively. Monitoring software is developed using VB6.0 for data input/output, flow control and online parameters setting. As a result, all functions are fulfilled with robust performance. It is concluded from results that one PC can monitor several PLCs using RS-485 communication.

  4. Experimental research and comparison of LDPC and RS channel coding in ultraviolet communication systems.

    Science.gov (United States)

    Wu, Menglong; Han, Dahai; Zhang, Xiang; Zhang, Feng; Zhang, Min; Yue, Guangxin

    2014-03-10

    We have implemented a modified Low-Density Parity-Check (LDPC) codec algorithm in ultraviolet (UV) communication system. Simulations are conducted with measured parameters to evaluate the LDPC-based UV system performance. Moreover, LDPC (960, 480) and RS (18, 10) are implemented and experimented via a non-line-of-sight (NLOS) UV test bed. The experimental results are in agreement with the simulation and suggest that based on the given power and 10(-3)bit error rate (BER), in comparison with an uncoded system, average communication distance increases 32% with RS code, while 78% with LDPC code.

  5. Signal Transduction through CsrRS Confers an Invasive Phenotype in Group A Streptococcus

    OpenAIRE

    Tran-Winkler, Hien J.; Love, John F.; Ioannis Gryllos; Wessels, Michael R.

    2011-01-01

    The CsrRS (or CovRS) two component system controls expression of up to 15% of the genome of group A Streptococcus (GAS). While some studies have suggested that the sensor histidine kinase CsrS responds to membrane perturbations as a result of various environmental stresses, other data have implicated the human antimicrobial peptide LL-37 and extracellular Mg(2+) as specific signals. We now report that Mg(2+) and LL-37 have opposite effects on expression of multiple genes that are activated or...

  6. Association Between hTERT rs2736100 Polymorphism and Sensitivity to Anti-cancer Agents

    Directory of Open Access Journals (Sweden)

    Julie eKim

    2013-08-01

    Full Text Available Background: The rs2736100 single nucleotide polymorphism (SNP is located in the intron 2 of human telomerase reverse transcriptase (hTERT gene. Recent genome-wide association studies (GWAS have consistently supported the strong association between this SNP and risk for multiple cancers. Given the important role of the hTERT gene and this SNP in cancer biology, we hypothesize that rs2736100 may also confer susceptibility to anti-cancer drug sensitivity. In this study we aim to investigate the correlation between the rs2736100 genotype and the responsiveness to anti-cancer agents in the NCI-60 cancer cell panel. Methods and Materials: The hTERT rs2736100 was genotyped in the NCI-60 cancer cell lines. The relative telomere length of each cell line was quantified using real-time PCR. The genotype was then correlated with publically available drug sensitivity data of two agents with telomerase-inhibition activity: Geldanamycin (HSP90 inhibitor and RHPS4/BRACO19 (G-quadruplex stabilizer as well as additional 110 commonly used agents with established mechanism of action. The association between rs2736100 and mutation status of TP53 gene was also tested.Results: The C allele of the SNP was significantly correlated with increased sensitivity to RHPS4/BRACO19 with an additive effect (r=-0.35, p=0.009 but not with Geldanamycin. The same allele was also significantly associated with sensitivity to antimitotic agents compared to other agents (p=0.003. The highest correlation was observed between the SNP and paclitaxel (r=-0.36, p=0.005. The telomere length was neither associated with rs2736100 nor with sensitivity to anti-cancer agents. The C allele of rs2736100 was significantly associated with increased mutation rate in TP53 gene (p=0.004.Conclusion: Our data suggested that the cancer risk allele of hTERT rs2736100 polymorphism may also affect the cancer cell response to both TERT inhibitor and anti-mitotic agents, which might be attributed to the elevated

  7. Adaptive efficient video transmission over the Internet based on congestion control and RS coding

    Institute of Scientific and Technical Information of China (English)

    黄伟红; 张福炎; 孙正兴

    2002-01-01

    An approach based on adaptive congestion control and adaptive error recovery with RS (Reed-Solomon) coding method is presented for efficient video transmission over the Internet.Featured by weighted moving average rate control and TCP-fdendliness,AVSP,a novel adaptive video streaming protocol,is designed with adjustable rate control parameters so as to respond quickly to the QoS status fluctuation during video transmission over the Internet.Combined with congestion control policy,an adaptive RS coding error recovery scheme with variable parameters is presented to enhance the robustness of MPEG video transmission over the Intemet with restriction to the total system bandwidth.``

  8. Single-nucleotide polymorphism rs7251246 in ITPKC is associated with susceptibility and coronary artery lesions in Kawasaki disease.

    Directory of Open Access Journals (Sweden)

    Ho-Chang Kuo

    Full Text Available Kawasaki disease (KD is a multi-systemic vasculitis that preferentially affects children. A single nucleotide polymorphism (SNP in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC has been identified to be an important polymorphism in the risk of KD. This study was conducted to comprehensively investigate the associations between all tagging SNPs of ITPKC in the risk of KD in a Taiwanese population. A total of 950 subjects (381 KD patients and 569 controls were recruited. Seven tagging SNPs (rs11673492, rs7257602, rs7251246, rs890934, rs10420685, rs2607420, rs2290692 were selected for TaqMan allelic discrimination assay. Clinical data of coronary artery lesions (CAL and aneurysms were collected for analysis. A significant association was found between rs7251246 in ITPKC and CAL formation. Haplotype analysis for ITPKC polymorphisms also confirmed this association in the patients with CAL and aneurysm formation. This is the first study to identify that SNP rs7251246 in ITPKC is associated with the severity of KD.

  9. PCSK1 rs6232 Is Associated with Childhood and Adult Class III Obesity in the Mexican Population

    Science.gov (United States)

    Villalobos-Comparán, Marisela; Villamil-Ramírez, Hugo; Villarreal-Molina, Teresa; Larrieta-Carrasco, Elena; León-Mimila, Paola; Romero-Hidalgo, Sandra; Jacobo-Albavera, Leonor; Liceaga-Fuentes, Adriana E.; Campos-Pérez, Francisco J.; López-Contreras, Blanca E.; Tusié-Luna, Teresa; del Río-Navarro, Blanca E.; Aguilar-Salinas, Carlos A.; Canizales-Quinteros, Samuel

    2012-01-01

    Background Common variants rs6232 and rs6235 in the PCSK1 gene have been associated with obesity in European populations. We aimed to evaluate the contribution of these variants to obesity and related traits in Mexican children and adults. Methodology/Principal Findings Rs6232 and rs6235 were genotyped in 2382 individuals, 1206 children and 1176 adults. Minor allele frequencies were 0.78% for rs6232 and 19.99% for rs6235. Rs6232 was significantly associated with childhood obesity and adult class III obesity (OR = 3.01 95%CI 1.64–5.53; P = 4×10−4 in the combined analysis). In addition, this SNP was significantly associated with lower fasting glucose levels (P = 0.01) and with increased insulin levels and HOMA-B (P = 0.05 and 0.01, respectively) only in non-obese children. In contrast, rs6235 showed no significant association with obesity or with glucose homeostasis parameters in any group. Conclusion/Significance Although rs6232 is rare in the Mexican population, it should be considered as an important risk factor for extreme forms of obesity. PMID:22737226

  10. INTEGRATION OF STORAGE CHARACTERISTIC WITH ON-LINE SERVICE CHARACTERISTIC OF AS/RS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Directed at how to integrated storage characteristic with on-line service characteristic of AS/RS, a solution based on database design and programming method is proposed. The results show that this model is reasonable and applicable while using in some small or middle enterprises material handling system.

  11. Face and emotion expression processing and the serotonin transporter polymorphism 5-HTTLPR/rs22531.

    Science.gov (United States)

    Hildebrandt, A; Kiy, A; Reuter, M; Sommer, W; Wilhelm, O

    2016-06-01

    Face cognition, including face identity and facial expression processing, is a crucial component of socio-emotional abilities, characterizing humans as highest developed social beings. However, for these trait domains molecular genetic studies investigating gene-behavior associations based on well-founded phenotype definitions are still rare. We examined the relationship between 5-HTTLPR/rs25531 polymorphisms - related to serotonin-reuptake - and the ability to perceive and recognize faces and emotional expressions in human faces. For this aim we conducted structural equation modeling on data from 230 young adults, obtained by using a comprehensive, multivariate task battery with maximal effort tasks. By additionally modeling fluid intelligence and immediate and delayed memory factors, we aimed to address the discriminant relationships of the 5-HTTLPR/rs25531 polymorphisms with socio-emotional abilities. We found a robust association between the 5-HTTLPR/rs25531 polymorphism and facial emotion perception. Carriers of two long (L) alleles outperformed carriers of one or two S alleles. Weaker associations were present for face identity perception and memory for emotional facial expressions. There was no association between the 5-HTTLPR/rs25531 polymorphism and non-social abilities, demonstrating discriminant validity of the relationships. We discuss the implications and possible neural mechanisms underlying these novel findings. PMID:27079569

  12. No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

    NARCIS (Netherlands)

    Hollestelle, Antoinette; van der Baan, Frederieke H.; Berchuck, Andrew; Johnatty, Sharon E.; Aben, Katja K.; Agnarsson, Bjarni A.; Aittomaki, Kristiina; Alducci, Elisa; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Antoniou, Antonis C.; Apicella, Carmel; Arndt, Volker; Arnold, Norbert; Arun, Banu K.; Arver, Brita; Ashworth, Alan; Baglietto, Laura; Balleine, Rosemary; Bandera, Elisa V.; Barrowdale, Daniel; Bean, Yukie T.; Beckmann, Lars; Beckmann, Matthias W.; Benitez, Javier; Berger, Andreas; Berger, Raanan; Beuselinck, Benoit; Bisogna, Maria; Bjorge, Line; Blomqvist, Carl; Bogdanova, Natalia V.; Bojesen, Anders; Bojesen, Stig E.; Bolla, Manjeet K.; Bonanni, Bernardo; Brand, Judith S.; Brauch, Hiltrud; Brenner, Hermann; Brinton, Louise; Brooks-Wilson, Angela; Bruinsma, Fiona; Brunet, Joan; Bruning, Thomas; Budzilowska, Agnieszka; Bunker, Clareann H.; Burwinkel, Barbara; Butzow, Ralf; Buys, Saundra S.; Caligo, Maria A.; Campbell, Ian; Carter, Jonathan; Chang-Claude, Jenny; Chanock, Stephen J.; Claes, Kathleen B. M.; Collee, J. Margriet; Cook, Linda S.; Couch, Fergus J.; Cox, Angela; Cramer, Daniel; Cross, Simon S.; Cunningham, Julie M.; Cybulski, Cezary; Czene, Kamila; Damiola, Francesca; Dansonka-Mieszkowska, Agnieszka; Darabi, Hatef; de la Hoya, Miguel; deFazio, Anna; Dennis, Joseph; Devilee, Peter; Dicks, Ed M.; Diez, Orland; Doherty, Jennifer A.; Domchek, Susan M.; Dorfling, Cecilia M.; Dork, Thilo; Dos Santos Silva, Isabel; du Bois, Andreas; Dumont, Martine; Dunning, Alison M.; Duran, Mercedes; Easton, Douglas F.; Eccles, Diana; Edwards, Robert P.; Ehrencrona, Hans; Ejlertsen, Bent; Ekici, Arif B.; Ellis, Steve D.; Engel, Christoph; Eriksson, Mikael; Fasching, Peter A.; Feliubadalo, Lidia; Figueroa, Jonine; Flesch-Janys, Dieter; Fletcher, Olivia; Fontaine, Annette; Fortuzzi, Stefano; Fostira, Florentia; Fridley, Brooke L.; Friebel, Tara; Friedman, Eitan; Friel, Grace; Frost, Debra; Garber, Judy; Garcia-Closas, Montserrat; Gayther, Simon A.; Gentry-Maharaj, Aleksandra; Gerdes, Anne-Marie; Giles, Graham G.; Glasspool, Rosalind; Glendon, Gord; Godwin, Andrew K.; Goodman, Marc T.; Gore, Martin; Greene, Mark H.; Grip, Mervi; Gronwald, Jacek; Kaulich, Daphne Gschwantler; Guenel, Pascal; Guzman, Starr R.; Haeberle, Lothar; Haiman, Christopher A.; Hall, Per; Halverson, Sandra L.; Hamann, Ute; Hansen, Thomas V. O.; Harter, Philipp; Hartikainen, Jaana M.; Healey, Sue; Hein, Alexander; Heitz, Florian; Henderson, Brian E.; Herzog, Josef; Hildebrandt, Michelle A. T.; Bogdan, Claus K.; Hogdall, Estrid; Hogervorst, Frans B. L.; Hopper, John L.; Humphreys, Keith; Huzarski, Tomasz; Imyanitov, Evgeny N.; Isaacs, Claudine; Jakubowska, Anna; Janavicius, Ramunas; Jaworska, Katarzyna; Jensen, Allan; Jensen, Uffe Birk; Johnson, Nichola; Jukkola-Vuorinen, Arja; Kabisch, Maria; Karlan, Beth Y.; Kataja, Vesa; Kauff, Noah; Kelemen, Linda E.; Kerin, Michael J.; Kiemeney, Lambertus A.; Kjaer, Susanne K.; Knight, Julia A.; Knol-Bout, Jacoba P.; Konstantopoulou, Irene; Kosma, Veli-Matti; Krakstad, Camilla; Kristensen, Vessela; Kuchenbaecker, Karoline B.; Kupryjanczyk, Jolanta; Laitman, Yael; Lambrechts, Diether; Lambrechts, Sandrina; Larson, Melissa C.; Lasa, Adriana; Laurent-Puig, Pierre; Lazaro, Conxi; Le, Nhu D.; Le Marchand, Loic; Leminen, Arto; Lester, Jenny; Levine, Douglas A.; Li, Jingmei; Liang, Dong; Lindblom, Annika; Lindor, Noralane; Lissowska, Jolanta; Long, Jirong; Lu, Karen H.; Lubinski, Jan; Lundvall, Lene; Lurie, Galina; Mai, Phuong L.; Mannermaa, Arto; Margolin, Sara; Mariette, Frederique; Marme, Frederik; Martens, John W. M.; Massuger, Leon F. A. G.; Maugard, Christine; Mazoyer, Sylvie; McGuffog, Lesley; McGuire, Valerie; McLean, Catriona; McNeish, Lain; Meindi, Alfons; Menegaux, Florence; Menendez, Primitiva; Menkiszak, Janusz; Menon, Usha; Mensenkamp, Arjen R.; Miller, Nicola; Milne, Roger L.; Modugno, Francesmary; Montagna, Marco; Moysich, Kirsten B.; Mueller, Heiko; Mulligan, Anna Marie; Muranen, Taru A.; Narod, Steven A.; Nathanson, Katherine L.; Ness, Roberta B.; Neuhausen, Susan L.; Nevanlinna, Heli; Neven, Patrick; Nielsen, Finn C.; Nielsen, Sune F.; Nordestgaard, Berge G.; Nussbaum, Robert L.; Odunsi, Kunle; Offit, Kenneth; Olah, Edith; Olopade, Olufunmilayo I.; Olson, Janet E.; Olson, Sara H.; Oosterwijk, Jan C.; Orlow, Irene; Orr, Nick; Orsulic, Sandra; Osorio, Ana; Ottini, Laura; Paul, James; Pearce, Celeste L.; Pedersen, Inge Sokilde; Peissel, Bernard; Pejovic, Tanja; Pelttari, Liisa M.; Perkins, Jo; Permuth-Wey, Jenny; Peterlongo, Paolo; Peto, Julian; Phelan, Catherine M.; Phillips, Kelly-Anne; Piedmonte, Marion; Pike, Malcolm C.; Platte, Radka; Plisiecka-Halasa, Joanna; Poole, Elizabeth M.; Poppe, Bruce; Pylkas, Katri; Radice, Paolo; Ramus, Susan J.; Rebbeck, Timothy R.; Reed, Malcolm W. R.; Rennert, Gad; Risch, Harvey A.; Robson, Mark; Rodriguez, Gustavo C.; Romero, Atocha; Rossing, Mary Anne; Rothstein, Joseph H.; Rudolph, Anja; Runnebaum, Ingo; Salani, Ritu; Salvesen, Helga B.; Sawyer, Elinor J.; Schildkraut, Joellen M.; Schmidt, Marjanka K.; Schmutzler, Rita K.; Schneeweiss, Andreas; Schoemaker, Minouk J.; Schrauder, Michael G.; Schumacher, Fredrick; Schwaab, Ira; Scuvera, Giulietta; Sellers, Thomas A.; Severi, Gianluca; Seynaeve, Caroline M.; Shah, Mitul; Shrubsole, Martha; Siddiqui, Nadeem; Sieh, Weiva; Simard, Jacques; Singer, Christian F.; Sinilnikova, Olga M.; Smeets, Dominiek; Sohn, Christof; Soller, Maria; Song, Honglin; Soucy, Penny; Southey, Melissa C.; Stegmaier, Christa; Stoppa-Lyonnet, Dominique; Sucheston, Lara; Swerdlow, Anthony; Tangen, Ingvild L.; Tea, Muy-Kheng; Teixeira, Manuel R.; Terry, Kathryn L.; Terry, Mary Beth; Thomassen, Mads; Thompson, Pamela J.; Tihomirova, Laima; Tischkowitz, Marc; Toland, Amanda Ewart; Tollenaar, Rob A. E. M.; Tomlinson, Ian; Torres, Diana; Truong, Therese; Tsimiklis, Helen; Tung, Nadine; Tworoger, Shelley S.; Tyrer, Jonathan P.; Vachon, Celine M.; Van 't Veer, Laura J.; van Altena, Anne M.; Van Asperen, C. J.; van den Berg, David; van den Ouweland, Ans M. W.; van Doom, Helena C.; Van Nieuwenhuysen, Els; van Rensburg, Elizabeth J.; Vergote, Ignace; Verhoef, Senno; Vierkant, Robert A.; Vijai, Joseph; Vitonis, Allison F.; von Wachenfeldt, Anna; Walsh, Christine; Wang, Qin; Wang-Gohrke, Shan; Wappenschmidt, Barbara; Weischer, Maren; Weitzel, Jeffrey N.; Weltens, Caroline; Wentzensen, Nicolas; Whittemore, Alice S.; Wilkens, Lynne R.; Winqvist, Robert; Wu, Anna H.; Wu, Xifeng; Yang, Hannah P.; Zaffaroni, Daniela; Zamora, M. Pilar; Zheng, Wei; Ziogas, Argyrios; Chenevix-Trench, Georgia; Pharoah, Paul D. P.; Rookus, Matti A.; Hooning, Maartje J.; Goode, Ellen L.

    2016-01-01

    Objective. Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particu

  13. No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

    NARCIS (Netherlands)

    A. Hollestelle (Antoinette); F.H. Van Der Baan (Frederieke H.); A. Berchuck (Andrew); S.E. Johnatty (Sharon); K.K.H. Aben (Katja); B.A. Agnarsson (Bjarni); K. Aittomäki (Kristiina); E. Alducci (Elisa); I.L. Andrulis (Irene); H. Anton-Culver (Hoda); N.N. Antonenkova (Natalia); A.C. Antoniou (Antonis C.); C. Apicella (Carmel); V. Arndt (Volker); N. Arnold (Norbert); B.K. Arun (Banu); B. Arver (Brita Wasteson); A. Ashworth (Alan); L. Baglietto (Laura); R. Balleine (Rosemary); E.V. Bandera (Elisa); D. Barrowdale (Daniel); Y.T. Bean (Yukie T.); L. Beckmann (Lars); M.W. Beckmann (Matthias); J. Benítez (Javier); A. Berger (Andreas); R. Berger (Raanan); B. Beuselinck (B.); M. Bisogna (Maria); L. Bjorge (Line); C. Blomqvist (Carl); N.V. Bogdanova (Natalia); A. Bojesen (Anders); S.E. Bojesen (Stig); M.K. Bolla (Manjeet); B. Bonnani (Bernardo); J.S. Brand (Judith S.); H. Brauch (Hiltrud); H. Brenner (Hermann); L.A. Brinton (Louise); A. Brooks-Wilson (Angela); F. Bruinsma (Fiona); J. Brunet (Joan); T. Brüning (Thomas); A. Budzilowska (Agnieszka); C.H. Bunker (Clareann H.); B. Burwinkel (Barbara); R. Butzow (Ralf); S.S. Buys (Saundra S.); M.A. Caligo (Maria); I. Campbell (Ian); J. Carter (Jonathan); J. Chang-Claude (Jenny); S.J. Chanock (Stephen J.); K.B.M. Claes (Kathleen B.M.); J.M. Collee (Margriet); L.S. Cook (Linda S.); F.J. Couch (Fergus); A. Cox (Angela); D.W. Cramer (Daniel); S.S. Cross (Simon); J.M. Cunningham (Julie); C. Cybulski (Cezary); K. Czene (Kamila); F. Damiola (Francesca); A. Dansonka-Mieszkowska (Agnieszka); H. Darabi (Hatef); M. de La Hoya (Miguel); A. DeFazio (Anna); J. Dennis (Joe); P. Devilee (Peter); E. Dicks (Ed); O. Díez (Orland); J.A. Doherty (Jennifer A.); S.M. Domchek (Susan); C.M. Dorfling (Cecilia); T. Dörk (Thilo); I.D.S. Silva (Isabel Dos Santos); A. Du Bois (Andreas); M. Dumont (Martine); A.M. Dunning (Alison); M. Duran (Mercedes); D.F. Easton (Douglas F.); D. Eccles (Diana); R. Edwards (Robert); H. Ehrencrona (Hans); B. Ejlertsen (Bent); A.B. Ekici (Arif); S.D. Ellis (Steve); C. Engel (Christoph); M. Eriksson (Mikael); P.A. Fasching (Peter); L. Feliubadaló (L.); J.D. Figueroa (Jonine); D. Flesch-Janys (Dieter); O. Fletcher (Olivia); A. Fontaine (Annette); S. Fortuzzi (S.); F. Fostira (Florentia); B.L. Fridley (Brooke); M.O.W. Friebel (Mark ); E. Friedman (Eitan); G. Friel (Grace); D. Frost (Debra); J. Garber (Judy); M. García-Closas (Montserrat); S.A. Gayther (Simon); A. Gentry-Maharaj (Aleksandra); A-M. Gerdes (Anne-Marie); G.G. Giles (Graham); R. Glasspool (Rosalind); G. Glendon (Gord); A.K. Godwin (Andrew K.); M.T. Goodman (Marc T.); M. Gore (Martin); M.H. Greene (Mark H.); M. Grip (Mervi); J. Gronwald (Jacek); D. Gschwantler-Kaulich (Daphne); P. Guénel (Pascal); S.R. Guzman (Starr R.); L. Haeberle (Lothar); C.A. Haiman (Christopher A.); P. Hall (Per); S.L. Halverson (Sandra L.); U. Hamann (Ute); T.V.O. Hansen (Thomas); P. Harter (Philipp); J.M. Hartikainen (J.); S. Healey (Sue); R. Hein (Rebecca); P.U. Heitz; B.E. Henderson (Brian); J. Herzog (Josef); M.A. T Hildebrandt (Michelle A.); C.K. Høgdall (Claus); E. Høgdall (Estrid); F.B.L. Hogervorst (Frans); J.L. Hopper (John); K. Humphreys (Keith); T. Huzarski (Tomasz); E.N. Imyanitov (Evgeny N.); C. Isaacs (Claudine); A. Jakubowska (Anna); R. Janavicius (Ramunas); K. Jaworska (Katarzyna); A. Jensen (Allan); U.B. Jensen; N. Johnson (Nichola); A. Jukkola-Vuorinen (Arja); M. Kabisch (Maria); B.Y. Karlan (Beth Y.); V. Kataja (Vesa); N. Kauff (Noah); L.E. Kelemen (Linda); M. Kerin (Michael); L.A.L.M. Kiemeney (Bart); M. Kjaer (Michael); J.A. Knight (Julia); J.P. Knol-Bout (Jacoba P.); I. Konstantopoulou (I.); V-M. Kosma (Veli-Matti); C. Krakstad (Camilla); V. Kristensen (Vessela); K.B. Kuchenbaecker (Karoline); J. Kupryjanczyk (Jolanta); Y. Laitman (Yael); D. Lambrechts (Diether); S. Lambrechts (Sandrina); M.C. Larson (Melissa); A. Lasa (Adriana); P. Laurent-Puig (Pierre); C. Lazaro (Conxi); N. Le (Nhu); L. Le Marchand (Loic); A. Leminen (Arto); K.J. Lester (Kathryn); D.A. Levine (Douglas); J. Li (Jingmei); D. Liang (Dong); A. Lindblom (Annika); N.M. Lindor (Noralane); J. Lissowska (Jolanta); J. Long (Jirong); K.H. Lu (Karen); J. Lubinski (Jan); L. Lundvall (Lene); G. Lurie (Galina); P.L. Mai (Phuong); A. Mannermaa (Arto); S. Margolin (Sara); F. Mariette (F.); F. Marme (Federick); J.W.M. Martens (John); L.F. Massuger (Leon); C. Maugard; S. Mazoyer (Sylvie); L. McGuffog (Lesley); W.P. McGuire; C.A. McLean (Catriona Ann); I. McNeish (Iain); A. Meindl (Alfons); F. Menegaux (Florence); P. Menéndez (Primitiva); J. Menkiszak (Janusz); U. Menon (Usha); A.R. Mensenkamp (Arjen); N. Miller (Nicola); R.L. Milne (Roger); F. Modugno (Francesmary); M. Montagna (Marco); K.B. Moysich (Kirsten B.); H. Mul̈ler (Heiko); A.-M. Mulligan (Anna-Marie); T.A. Muranen (Taru); S.A. Narod (Steven A.); K.L. Nathanson (Katherine); R.B. Ness (Roberta B.); S.L. Neuhausen (Susan); H. Nevanlinna (Heli); P. Neven (Patrick); F. Nielsen (Finn); S.F. Nielsen (Sune); B.G. Nordestgaard (Børge); R. Nussbaum (Robert); K. Odunsi (Kunle); K. Offit (Kenneth); E. Olah; O.I. Olopade (Olufunmilayo I.); J.E. Olson (Janet); S.H. Olson (Sara); J.C. Oosterwijk (Jan); I. Orlow (Irene); N. Orr (Nick); S. Orsulic (Sandra); A. Osorio (Ana); L. Ottini (Laura); J. Paul (James); C.L. Pearce (Celeste); I.S. Pedersen (Inge Sokilde); B. Peissel (Bernard); T. Pejovic (Tanja); L.M. Pelttari (Liisa); J. Perkins (Jo); J. Permuth-Wey (Jenny); P. Peterlongo (Paolo); J. Peto (Julian); C. Phelan (Catherine); K.-A. Phillips (Kelly-Anne); M. Piedmonte (Marion); M.C. Pike (Malcolm C.); R. Platte (Radka); J. Plisiecka-Halasa (Joanna); E.M. Poole (Elizabeth); B. Poppe (Bruce); K. Pykäs (Katri); P. Radice (Paolo); S.J. Ramus (Susan); R. Rebbeck (Timothy); M.W.R. Reed (Malcolm W.R.); G. Rennert (Gad); H. Risch (Harvey); M. Robson (Mark); G. Rodriguez (Gustavo); A. Romero (Atocha); M.A. Rossing (Mary Anne); J.H. Rothstein (Joseph H.); A. Rudolph (Anja); I.B. Runnebaum (Ingo); R. Salani (Ritu); H.B. Salvesen (Helga); E.J. Sawyer (Elinor); J.M. Schildkraut (Joellen); M.K. Schmidt (Marjanka); R.K. Schmutzler (Rita); A. Schneeweiss (Andreas); M. Schoemaker (Minouk); A. Schrauder (André); F.R. Schumacher (Fredrick); I. Schwaab (Ira); G. Scuvera (Giulietta); T.A. Sellers (Thomas A.); G. Severi (Gianluca); C.M. Seynaeve (Caroline); M. Shah (Mitul); M. Shrubsole (Martha); N. Siddiqui (Nadeem); W. Sieh (Weiva); J. Simard (Jacques); C.F. Singer (Christian); O. Sinilnikova (Olga); D. Smeets (Dominiek); C. Sohn (Christof); M. Soller (Maria); H. Song (Honglin); P. Soucy (Penny); M.C. Southey (Melissa); C. Stegmaier (Christa); D. Stoppa-Lyonnet (Dominique); L. Sucheston (Lara); A.J. Swerdlow (Anthony ); I.L. Tangen (Ingvild L.); M.-K. Tea; P.J. Teixeira; K.L. Terry (Kathryn); M.B. Terry (Mary Beth); M. Thomassen (Mads); P.J. Thompson (Pamela J.); L. Tihomirova (Laima); M. Tischkowitz (Marc); A.E. Toland (Amanda); R.A.E.M. Tollenaar (Rob); I. Tomlinson (Ian); D. Torres (Diana); T. Truong (Thérèse); H. Tsimiklis (Helen); N. Tung (Nadine); S. Tworoger (Shelley); J.P. Tyrer (Jonathan); C. Vachon (Celine); L.J. van 't Veer (Laura); A.M. van Altena (Anne); C.J. van Asperen (Christi); D. Van Den Berg (David); A.M.W. van den Ouweland (Ans); H.C. van Doorn (Helena); E. Van Nieuwenhuysen (Els); E.J. van Rensburg (Elizabeth); I. Vergote (Ignace); S. Verhoef; R.A. Vierkant (Robert); J. Vijai (Joseph); A.F. Vitonis (Allison); A. von Wachenfeldt (Anna); C.S. Walsh (Christine); Q. Wang (Qing); S. Wang-Gohrke (Shan); B. Wapenschmidt (Barbara); M. Weischer (Maren); J.N. Weitzel (Jeffrey); C. Weltens (Caroline); N. Wentzensen (N.); A.S. Whittemore (Alice S.); L.R. Wilkens (Lynne R.); R. Winqvist (Robert); A.H. Wu (Anna); X. Wu (Xifeng); H.P. Yang (Hannah P.); D. Zaffaroni (Daniela); M.P. Zamora (Pilar); W. Zheng (Wei); A. Ziogas (Argyrios); G. Chenevix-Trench (Georgia); P.D.P. Pharoah (Paul); M.A. Rookus (Matti); M.J. Hooning (Maartje); E.L. Goode (Ellen L.); Breast Cancer Family Register; EMBRACE; GENICA Network; HEBON; SWE-BRCA

    2016-01-01

    textabstractObjective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasiz

  14. Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis

    Directory of Open Access Journals (Sweden)

    He LL

    2016-03-01

    Full Text Available Lanlan He,1,* Yong Wang2,* 1Emergency Department, Zhenjiang First People’s Hospital, Zhenjiang, People’s Republic of China; 2Department of Interventional Radiology and Vascular Surgery, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, People’s Republic of China *Both authors contributed equally to this work Purpose: Several molecular epidemiological studies have investigated the association between OPN rs11730582 C>T polymorphism and cancer risk, but the results are inconsistent. Hence, a meta-analysis was conducted to determine the association of this polymorphism with cancer risk. Materials and methods: The related articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases. Pooled odds ratios and 95% confidence intervals were calculated to evaluate the strength of the associations. A random-effects model or fixed-effects model was employed depending on the heterogeneity. Results: A total of ten case-control studies involving 2,749 cancer cases and 3,398 controls were included in the meta-analysis. In overall analysis, OPN rs11730582 C>T polymorphism was not associated with cancer risk. In a stratified analysis by cancer type, no significant association was found between OPN rs11730582 C>T polymorphism and the risk of glioma, gastric cancer, and other cancers. Conclusion: This meta-analysis suggests that OPN rs11730582 C>T polymorphism is not associated with cancer susceptibility. Keywords: osteopontin, polymorphism, cancer, risk 

  15. Genome Sequence of Penicillium solitum RS1, Which Causes Postharvest Apple Decay.

    Science.gov (United States)

    Yu, Jiujiang; Wu, Guangxi; Jurick, Wayne M; Gaskins, Verneta L; Yin, Yanbin; Yin, Guohua; Bennett, Joan W; Shelton, Daniel R

    2016-01-01

    Penicillium species cause postharvest decay, commonly known as blue mold, in pome fruits, such as apples and pears. To devise novel strategies to prevent and reduce economic losses during storage, the genome sequence of Penicillium solitum RS1 is reported here for the first time.

  16. MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia

    NARCIS (Netherlands)

    Patel, V.S.; Kelly, S.; Wright, C.; Gupta, C.N.; Arias Vasquez, A.; Perrone-Bizzozero, N.; Ehrlich, S.; Wang, L.; Bustillo, J.R.; Morris, D.; Corvin, A.; Cannon, D.M.; McDonald, C.; Donohoe, G.; Calhoun, V.D.; Turner, J.A.

    2015-01-01

    Genome-wide association studies implicate the MIR137HG risk variant rs1625579 (MIR137HGrv) within the host gene for microRNA-137 as a potential regulator of schizophrenia susceptibility. We examined the influence of MIR137HGrv genotype on 17 subcortical and callosal volumes in a large sample of indi

  17. Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk

    DEFF Research Database (Denmark)

    Lurie, Galina; Wilkens, Lynne R; Thompson, Pamela J;

    2011-01-01

    The association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2) gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-control studies within the Ovarian Cancer Association Consortium...

  18. X-ray crystal structure of divalent metal-activated ß-xyloisdase, RS223BX

    Science.gov (United States)

    We report the first X-ray structure of a glycoside hydrolase family 43 ß-xylosidase, RS223BX, which is strongly activated by the addition of divalent metal cations. The 2.69 Å structure reveals that the Ca2+ cation is located at the back of the active site pocket. The Ca2+ coordinates to H274 to sta...

  19. Design og samarbejde på tværs af kulturer

    DEFF Research Database (Denmark)

    Eriksen, Kaare Riise

    2005-01-01

    Artiklen beskriver erfaringerne fra en studietur og workshop med designstuderende fra aalborg universitet, Aalborg og Tsinghua University, Beijing, herunder refleksioner over forskelle i studerendes faglige styrker samt de praktiske problemer og muligheder for samarbejde på tværs af sproglige og ...

  20. Applications of RS, GPS and GIS to Forest Management in China

    Institute of Scientific and Technical Information of China (English)

    李伟林; 肖波; 李郁

    2000-01-01

    Applications of remote sensing (RS), global positioning system (GPS), geographic information system(GIS) and combination of three-S techniques in the forest management are introduced. It indicates that,with the quickly improvement of the computer technique, the three-S system will become a very important part of the forestry management system.

  1. Exploring Strategies for Parallel Computing of RS Data Assimilation with SWAP-GA

    Directory of Open Access Journals (Sweden)

    Shamim Akhter

    2007-01-01

    Full Text Available An agro-hydrological simulation model is useful for agriculture monitoring. One issue in running such model is parameter identification, especially when the target area is large such as provincial or country level. Remote Sensing (RS provides us with useful information over large area. RS cannot observe input parameters of agro-hydrological models directly. However, a method to estimate input parameters of such model from RS using data assimilation has been proposed by Ines[1] using the SWAP (Soil, Water, Atmosphere and Plant model. Genetic Algorithm (GA was used in this optimization process. The combined model of SWAP and GA is called SWAP-GA model. When dealing with sufficiently large and complex processing with RS data, single computers time processing extends to unacceptable limits. It becomes necessary to introduce methods for using higher processing power such as distributed computing. Cluster based computing support both high performance and load balancing parallel or distributed applications. Implementing SWAP-GA in Cluster computers will remove the computational time constraint, with this hypothesis three different parallel SWAP-GA approaches are proposed in this study. Distributed population (where GA will work on distributed manner, Distributed pixel (Pixels are processed in parallel and Mixed of distributed population and pixel model called Hybrid model. The technical considerations of implementing such methodologies are visited here.

  2. Relationship of rs4340 and rs4343 polymorphisms of angiotensin-converting enzyme gene to atrial fibrillation%血管紧张素转换酶基因rs4340和rs4343多态性与心房颤动的相关性

    Institute of Scientific and Technical Information of China (English)

    王亚珠; 李瑛; 范晋奇; 肖培林; 凌智瑜; 殷跃辉

    2012-01-01

    Objective To investigate the relationship of rs4340 and rs4343 polymorphisms of angiotensin- converting enzyme (ACE) gene to atrial fibrillation. Methods Venous blood samples were collected from 102 patients with atrial fibrillation, visiting four hospitals of class AAA in Chongqing Region, as well as 100 hospitalized patients without history of atrial fibrillation, from which genomic DNAs were extracted and analyzed for rs4340 and rs4343 polymorphisms of ACE gene by single nucleotide polymorphism-restriction fragment length polymorphism (SNP-RFLP) method and gene sequencing. Results The genotype distribution and allele frequency of rs4340 in the patients with atrial fibrillation showed no significant difference (P > 0. 05), while those of rs4343 showed significant difference (P ≤ 0. 001), with those in patients without history of atrial fibrillation. As compared with those in the patients without history of atrial fibrillation, the frequencies of GG + AG genotypes was significantly higher than that of AA genotype in patients with atrial fibrillation (P 0. 05). However.both left and right atrial dimensions in the patients with atrial fibrillation of 11/ AA genotype were significantly smaller, while those of II/AG genotype were significantly larger, than those of other genotypes (P < 0. 001). Conclusion The rs4343 polymorphism of ACE gene was significantly related to atrial fibrillation. II/AA genotype was a protective factor, while II/AG genotype was a risk factors for onset and progress of atrial fibrillation .%目的 探讨血管紧张素转换酶(Angiotensin converting enzyme,ACE)基因rs4340和rs4343多态性与心房颤动(简称房颤)的相关性.方法 选择重庆地区4家三甲医院就诊的102例房颤患者及同期住院的无房颤病史患者100例,抽取患者静脉血,分别提取基因组DNA,采用单核苷酸多态性-限制性片段长度多态性(Single nucleotide polymorphism,restriction fragment length polymorphism,SNP-RFLP)法及基因测序检测ACE基因rs

  3. COSMO-RS-based extractant screening for phenol extraction as model system

    NARCIS (Netherlands)

    Burghoff, B.; Goetheer, E.L.V.; Haan, A.B. de

    2008-01-01

    The focus of this investigation is the development of a fast and reliable extractant screening approach. Phenol extraction is selected as the model process. A quantum chemical conductor-like screening model for real solvents (COSMO-RS) is combined with molecular design considerations. For this purpo

  4. No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

    DEFF Research Database (Denmark)

    Hollestelle, Antoinette; van der Baan, Frederieke H; Berchuck, Andrew;

    2015-01-01

    OBJECTIVE: Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing part...

  5. Integrable mappings derived from the $\\Delta \\Delta RsG$ equation

    OpenAIRE

    Iatrou, Apostolos

    2003-01-01

    In this paper we consider the integrability of the mappings derived from the double discrete related sine-Gordon $(\\Delta \\Delta RsG)$ equation, which we recently introduced in the paper Higher dimensional integrable mappings, under an appropriate periodicity condition.

  6. Cosmological constant problem in a scenario with compactifications (RS-I model)

    CERN Document Server

    Martinez-Robles, C

    2016-01-01

    In this letter, we apply the Randall-Sundrum (RS) model, a scenario based on compactifications, to control the UV divergence of the zero-point energy density equation for the vacuum fluctuations, which has been unsuccessfully addressed to the cosmological constant (CC) due to a heavy discrepancy between theory and observation. Historically, the problem of CC has been shelved in the RS point of view, having few or non literature on the subject. In this sense and as done with the hierarchy problem, we apply the RS model to solve this difference via extra dimensions; we also describe how brane effects could be the solution to this substantial difference. It should be noticed that this problem is studied assuming first Minkoswki type branes, and then followed by cosmologically more realistic FLRW type branes. We finally find some remarkably interesting consequences in the RS scenario: The CC problem can be solved via compactification of the extra dimension and the compactification radius turns out to be approxima...

  7. Studies on the correlation of PON1 gene rs854572 single nucleotide polymorphism to clopidogrel resistance

    Directory of Open Access Journals (Sweden)

    Teng-fei LIU

    2012-10-01

    Full Text Available Objective To investigate the correlation of the single nucleotide polymorphism (SNP of PON1 (Paraoxonase-1 gene rs854572 to the occurrence of clopidogrel resistance (CR. Methods A case-control method was employed in present study. A total of 850 hospitalized patients with coronary artery diseases (CAD in General Hospital of Shenyang Command were enrolled. The residual platelet aggregation rate (RPA induced by 20μmol/L of adenosine diphosphate (ADP was detected by optical nephelometry, and RPA≥70% was defined as CR. Accordingly, all the enrolled 850 patients were then divided into CR group (n=215 and non-CR (NCR group (n=635. Polymerase chain reaction (PCR and pyrophosphate sequencing were executed to determine the genotypes and the allele frequencies of PON1 gene rs854572. Results The genotype frequencies in rs854572 of PON1 gene conformed well to the Hardy-Weinberg equilibrium in both CR group and NCR group. Three frequencies of genotype CC, CG and GG were 23.7%, 49.3%, 27.0% in CR group, and 24.1%, 50.2%, 25.7% in NCR groups, respectively. No significant difference in genotype and allele frequency existed between CR group and NCR group (P=0.93 and 0.76, respectively. Logistic regression analysis revealed that no correlation between rs854572 SNP of PON1 gene and the formation of CR in patients with CAD after adjustment of correspondent factors including age, gender, body mess index, smoking, hypertension, diabetes mellitus and hyperlipidemia. Conclusions It is considered that no correlation exists between PON1 gene rs854572 polymorphism and clopidogrel resistance in patients with coronary heart disease.

  8. Synchronization, TIGoRS, and Information Flow in Complex Systems: Dispositional Cellular Automata.

    Science.gov (United States)

    Sulis, William H

    2016-04-01

    Synchronization has a long history in physics where it refers to the phase matching of two identical oscillators. This notion has been extensively studied in physics as well as in biology, where it has been applied to such widely varying phenomena as the flashing of fireflies and firing of neurons in the brain. Human behavior, however, may be recurrent but it is not oscillatory even though many physiological systems do exhibit oscillatory tendencies. Moreover, much of human behaviour is collaborative and cooperative, where the individual behaviours may be distinct yet contemporaneous (if not simultaneous) and taken collectively express some functionality. In the context of behaviour, the important aspect is the repeated co-occurrence in time of behaviours that facilitate the propagation of information or of functionality, regardless of whether or not these behaviours are similar or identical. An example of this weaker notion of synchronization is transient induced global response synchronization (TIGoRS). Previous work has shown that TIGoRS is a ubiquitous phenomenon among complex systems, enabling them to stably parse environmental transients into salient units to which they stably respond. This leads to the notion of Sulis machines, which emergently generate a primitive linguistic structure through their dynamics. This article reviews the notion of TIGoRS and its expression in several complex systems models including tempered neural networks, driven cellular automata and cocktail party automata. The emergent linguistics of Sulis machines are discussed. A new class of complex systems model, the dispositional cellular automaton is introduced. A new metric for TIGoRS, the excess synchronization, is introduced and applied to the study of TIGoRS in dispositional cellular automata. It is shown that these automata exhibit a nonlinear synchronization response to certain perturbing transients.

  9. Ranitidine hydrochloride-loaded ethyl cellulose and eudragit Rs 100 buoyant microspheres: Effect of ph modifiers

    Directory of Open Access Journals (Sweden)

    N R Kotagale

    2011-01-01

    Full Text Available A floating type of dosage form of ranitidine hydrochloride in the form of microspheres capable of floating on simulated gastric fluid was prepared by solvent evaporation technique. Microspheres prepared with ethyl cellulose, Eudragit® RS100 alone or in combination were evaluated for percent yield, drug entrapment, percent buoyancy and drug release and the results demonstrated satisfactory performance. Microspheres exhibited ranitidine hydrochloride release influenced by changing ranitidine hydrochloride-polymer and ranitidine hydrochloride-polymer-polymer ratio. Incorporation of a pH modifier has been the usual strategy employed to enhance the dissolution rate of weakly basic drug from floating microspheres. Further citric acid, fumaric acid, tartaric acid were employed as pH modifiers. Microspheres prepared with ethyl cellulose, Eudragit® RS100 and their combination that showed highest release were utilized to study the effect of pH modifiers on ranitidine hydrochloride release from microspheres which is mainly affected due to modulation of microenvironmental pH. In vitro release of ranitidine hydrochloride from microspheres into simulated gastric fluid at 37° showed no significant burst effect. However the amount of release increased with time and significantly enhanced by pH modifiers. 15% w/w concentration of fumaric acid provide significant drug release from ranitidine hydrochloride microspheres prepared with ranitidine hydrochloride:ethyl cellulose (1:3, ranitidine hydrochloride:Eudragit® RS100 (1:2 and ranitidine hydrochloride:ethyl cellulose:Eudragit® RS100 (1:2:1 whereas citric acid, tartaric acid showed significant cumulative release at 20% w/w. In all this study suggest that ethyl celluose, Eudragit® RS100 alone or in combination with added pH modifiers can be useful in floating microspheres which can be proved beneficial to enhance the bioavailability of ranitidine hydrochloride.

  10. Expanding the three Rs to meet new challenges in humane animal experimentation.

    Science.gov (United States)

    Schuppli, Catherine A; Fraser, David; McDonald, Michael

    2004-11-01

    The Three Rs are the main principles used by Animal Ethics Committees in the governance of animal experimentation, but they appear not to cover some ethical issues that arise today. These include: a) claims that certain species should be exempted on principle from harmful research; b) increased emphasis on enhancing quality of life of research animals; c) research involving genetically modified (GM) animals; and d) animals bred as models of disease. In some cases, the Three Rs can be extended to cover these developments. The burgeoning use of GM animals in science calls for new forms of reduction through improved genetic modification technology, plus continued attention to alternative approaches and cost-benefit analyses that include the large numbers of animals involved indirectly. The adoption of more expanded definitions of refinement that go beyond minimising distress will capture concerns for enhancing the quality of life of animals through improved husbandry and handling. Targeting refinement to the unpredictable effects of gene modification may be difficult; in these cases, careful attention to monitoring and endpoints are the obvious options. Refinement can also include sharing data about the welfare impacts of gene modifications, and modelling earlier stages of disease, in order to reduce the potential suffering caused to disease models. Other issues may require a move beyond the Three Rs. Certain levels of harm, or numbers and use of certain species, may be unacceptable, regardless of potential benefits. This can be addressed by supplementing the utilitarian basis of the Three Rs with principles based on deontological and relational ethics. The Three Rs remain very useful, but they require thoughtful interpretation and expansion in order for Animal Ethics Committees to address the full range of issues in animal-based research. PMID:15656775

  11. Effect of Bcl-2 rs956572 polymorphism on age-related gray matter volume changes.

    Directory of Open Access Journals (Sweden)

    Mu-En Liu

    Full Text Available The anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2 gene is a major regulator of neural plasticity and cellular resilience. Recently, the Bcl-2 rs956572 single nucleotide polymorphism was proposed to be a functional allelic variant that modulates cellular vulnerability to apoptosis. Our cross-sectional study investigated the genetic effect of this Bcl-2 polymorphism on age-related decreases in gray matter (GM volume across the adult lifespan. Our sample comprised 330 healthy volunteers (191 male, 139 female with a mean age of 56.2±22.0 years (range: 21-92. Magnetic resonance imaging and genotyping of the Bcl-2 rs956572 were performed for each participant. The differences in regional GM volumes between G homozygotes and A-allele carriers were tested using optimized voxel-based morphometry. The association between the Bcl-2 rs956572 polymorphism and age was a predictor of regional GM volumes in the right cerebellum, bilateral lingual gyrus, right middle temporal gyrus, and right parahippocampal gyrus. We found that the volume of these five regions decreased with increasing age (all P<.001. Moreover, the downward slope was steeper among the Bcl-2 rs956572 A-allele carriers than in the G-homozygous participants. Our data provide convergent evidence for the genetic effect of the Bcl-2 functional allelic variant in brain aging. The rs956572 G-allele, which is associated with significantly higher Bcl-2 protein expression and diminished cellular sensitivity to stress-induced apoptosis, conferred a protective effect against age-related changes in brain GM volume, particularly in the cerebellum.

  12. Synchronization, TIGoRS, and Information Flow in Complex Systems: Dispositional Cellular Automata.

    Science.gov (United States)

    Sulis, William H

    2016-04-01

    Synchronization has a long history in physics where it refers to the phase matching of two identical oscillators. This notion has been extensively studied in physics as well as in biology, where it has been applied to such widely varying phenomena as the flashing of fireflies and firing of neurons in the brain. Human behavior, however, may be recurrent but it is not oscillatory even though many physiological systems do exhibit oscillatory tendencies. Moreover, much of human behaviour is collaborative and cooperative, where the individual behaviours may be distinct yet contemporaneous (if not simultaneous) and taken collectively express some functionality. In the context of behaviour, the important aspect is the repeated co-occurrence in time of behaviours that facilitate the propagation of information or of functionality, regardless of whether or not these behaviours are similar or identical. An example of this weaker notion of synchronization is transient induced global response synchronization (TIGoRS). Previous work has shown that TIGoRS is a ubiquitous phenomenon among complex systems, enabling them to stably parse environmental transients into salient units to which they stably respond. This leads to the notion of Sulis machines, which emergently generate a primitive linguistic structure through their dynamics. This article reviews the notion of TIGoRS and its expression in several complex systems models including tempered neural networks, driven cellular automata and cocktail party automata. The emergent linguistics of Sulis machines are discussed. A new class of complex systems model, the dispositional cellular automaton is introduced. A new metric for TIGoRS, the excess synchronization, is introduced and applied to the study of TIGoRS in dispositional cellular automata. It is shown that these automata exhibit a nonlinear synchronization response to certain perturbing transients. PMID:27033136

  13. Association Between rs1344706 of ZNF804A and Schizophrenia:A Meta-analysis

    Institute of Scientific and Technical Information of China (English)

    Meiyan Zhu; Tongyang Liu; Jihong Zhang; Shuting Jia; Wenru Tang; Ying Luo

    2014-01-01

    Schizophrenia is one of the most serious mental diseases found in humans. Previous studies indicated that the single nucleotide polymorphism (SNP) rs1344706 in the gene ZNF804A encoding zinc finger protein 804A was associated with schizophrenia in Caucasian population but not in Chinese Han population. However, current results are conflicting in Asian population. In the present study, a meta-analysis was performed to revisit the association between rs1344706 and the risk of schizophrenia in Asian, Caucasian and other populations. Electronic search of PubMed database identified 25 case–control studies with available genotype frequencies of rs1344706 for the meta-analysis, involving a total of 15,788 cases and 22,654 controls. A pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the association. The current meta-analysis showed an association between rs1344706 and schizophrenia in Caucasian populations (P= 0.028, OR= 1.138, 95% CI: 1.014–1.278; P = 0.004 for heterogeneity) and Asian populations (P = 0.008, OR = 1.092, 95% CI: 1.023–1.165; P = 0.001 for heterogeneity), but not in other populations (P= 0.286, OR= 1.209, 95% CI: 0.853–1.714, P = 0.120 for heterogeneity). Egger’s test (P > 0.05) and Begg’s test (P>0.05) are both suggestive of the lack of publication bias for the included studies. Thus, the absence of association in other populations suggests a genetic heterogeneity in the susceptibility of schizophrenia and demonstrates the difficulties in replicating genome-wide association study findings regarding schizophrenia across different ethnic populations. To validate the association between rs1344706 and schizophrenia, further studies with larger participant populations worldwide are needed.

  14. Optical isolation and surge protection of RS-232 port%RS-232端口光电隔离型电涌保护器

    Institute of Scientific and Technical Information of China (English)

    王金虎; 李祥超; 刘晓东; 黄鹏良

    2011-01-01

    根据气体放电管和瞬态抑制二极管的保护特性,合理选择退耦元件参数,实现多级SPD间的能量配合,并结合光纤的保护性能设计RS-232接口的保护电路.最后利用雷电冲击试验平台LST-6kV/3 kA、ICGS冲击平台以及DF1641C函数发生器对保护电路进行实验,以验证设计的方案.实验结果表明:在加上保护器件后,通信端口的抗雷电过压能力得到了很大的提高,并且加入该保护电路以后基本不会对原电路产生插入损耗.%Lightning over-voltages are the important reasons for losses in communication port, which make it neces-sary and urgent to study into the lightning protection of communication port. According to the protection characteris-tics of gas discharge tube and transient voltage suppressor, the decoupling components are selected carefully to a-chieve the rational energy correspondence between multi-level SPD. Besides that,optical design is also considered to design protective circuit of RS-232 port. Finally,in order to verify the design scheme,the lightning impact platform called LST-6 kV/3 kA and ICGS and function generator called DF1641C are employed for the experiments. The ex-periments show that bearing capacity of lightning over-voltage of communication port RS-232 has been greatly im-proved and will not produce insertion loss to original circuit by adding the protection circuit.

  15. 9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer

    DEFF Research Database (Denmark)

    Warren, Helen; Dudbridge, Frank; Fletcher, Olivia;

    2012-01-01

    Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686).......Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686)....

  16. The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

    NARCIS (Netherlands)

    Campa, Daniele; Huesing, Anika; Mckay, James D.; Sinilnikova, Olga; Vogel, Ulla; Tjonneland, Anne; Overvad, Kim; Stegger, Jakob; Clavel-Chapelon, Francoise; Chabbert-Buffet, Nathalie; Fagherazzi, Guy; Trichopoulou, Antonia; Zylis, Dimosthenis; Oustoglou, Erifili; Rohrmann, Sabine; Teucher, Birgit; Fisher, Eva; Boeing, Heiner; Masala, Giovanna; Krogh, Vittorio; Sacerdote, Carlotta; Panico, Salvatore; Tumino, Rosario; Onland-Moret, N. Charlotte; van Gils, Carla H.; Bueno-de-Mesquita, H. Bas; Lund, Eiliv; Dolores Chirlaque, Maria; Sala, Nuria; Ramon Quiros, Jose; Ardanaz, Eva; Amiano, Pilar; Molina-Montes, Esther; Hallmans, Goran; Lenner, Per; Travis, Ruth C.; Key, Timothy J.; Wareham, Nick; Khaw, Kay-Tee; Rinaldi, Sabina; Slimani, Nadia; Chajes, Veronique; Siddiq, Afshan; Riboli, Elio; Kaaks, Rudolf; Canzian, Federico

    2010-01-01

    Background: The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatne

  17. Association of a single nucleotide polymorphism rs821597 in gene disrupted-in-schizophrenia-1 with white matter integrity

    Institute of Scientific and Technical Information of China (English)

    魏钦令

    2014-01-01

    Objective To explore the association of a single nucleotide polymorphism(SNP)rs821597 in gene disrupted-in-schizophrenia-1(DISC1)with white matter integrity in healthy people.Methods Sixty healthy persons were genotyped at the SNP rs821597 in DISC1 and were divided into two groups(risk allele carriers and non-risk allele

  18. Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study

    DEFF Research Database (Denmark)

    Jess, T; Zimmermann, E; Kring, S I I;

    2008-01-01

    years; OR, 1.36; 95% confidence interval (CI), 1.06-1.74) and increased LBM in adulthood (OR, 1.24; 95% CI, 1.14-1.35). CONCLUSION: Fatness induced by FTO rs9939609 in early childhood is sustained until early adulthood, where further weight gain may occur. FTO rs9939609 may, however, also be associated...

  19. Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655

    DEFF Research Database (Denmark)

    Søndergaard, Helle Bach; Sellebjerg, Finn; Hillert, Jan;

    2011-01-01

    -nucleotide polymorphism rs4763655. We could confirm a marginally significant association between rs4763655 and MS (P=0.046, odds ratio=1.06 (1.00-1.13)) in a large Scandinavian case-control study of 5367 MS patients and 4485 controls. The expression of KLRB1 in blood from MS patients was higher compared with healthy...

  20. Serial Communication between Intelligent Instrument and PLC Based on RS-485%基于RS-485的智能仪表与PLC串行通讯

    Institute of Scientific and Technical Information of China (English)

    李如甲; 程武山; 董林

    2011-01-01

    Through adopting S7-200 PLC as controllers,this paper introduced the RS -485 serial communication technology and the communication way of intelligent instrument of micro-ohm. It analyzed the design of hardware connection and programming between PLC and intelligent instrument. The program has been applied to a project of the design of fuse line,and enhanced the o-verall stability and reliability of the control system.%采用S7-200PLC作为控制器,介绍了RS-485串行通讯技术和智能仪表-微欧仪的通讯方式,详细分析了微欧仪与PLC之间通讯的硬件连接设计和程序设计.该方案已经被实际应用于某熔断器生产线开发与研究的项目中,达到了提高控制系统的整体稳定性和可靠性的目的.

  1. Cão naturalmente infectado por Trypanosoma evansi em Santa Maria, RS, Brasil Dog naturally infected by Trypanosoma evansi in Santa Maria, RS, Brasil

    Directory of Open Access Journals (Sweden)

    Carina Franciscato

    2007-02-01

    Full Text Available Descreve-se, neste trabalho, as alterações hematológicas e o proteinograma de um cão naturalmente infectado por Trypanosoma evansi. Este animal apresentou anemia normocítica normocrômica, leucopenia com linfopenia seguida por neutropenia e linfocitose; trombocitopenia; hiperproteinemia com aumento das frações beta e gama globulinas e hipoalbuminemia. Por ser este o primeiro relato de infecção por T. evansi em cães no município de Santa Maria, RS, destaca-se a sua importância epidemiológica, alertando os médicos veterinários para a existência de reservatórios do parasita na região e para a possibilidade de novos achados laboratoriais.This paper describes the hematological alterations and proteinogram of a dog naturally infected by Trypanosoma evansi. This dog was presented with normochromic-normocytic anemia, leucopenia with lymphopenia followed for neutrophenia and lymphocitosis; and trombocitopenia. Hyperproteinemia with an increase of beta and gamma globulin fractions and hypoalbuminemia. By being the first case reported of T. evansi infection in dogs in Santa Maria, RS, Brazil, the epidemiological significance of such findings will alert the veterinarians to the existence of a possible parasite's reservoir in the region warning to the possibility of new laboratory findings.

  2. The New RS CVn Binary V1034 Her Revisited and the orbital period - Activity relation of Short-period RS CVn binaries using photometric distortion amplitude

    CERN Document Server

    liyun, Zhang

    2011-01-01

    This paper presents new CCD BVRI light curves of the newly discovered RS CVn eclipsing binary V1034 Her in 2009 and 2010, which shapes are different from the previous published results. They show asymmetric outside eclipse and we try to use a spot model to explain the phenomena. Using the Wilson-Devinney program with one-spot or two-spots model, photometric solutions of the system and starspot parameters were derived. Comparing the two results, it shows that the case of two spots is better successful in reproducing the light-curve distortions. For all the spot longitudes, it suggests that the trend towards active longitude belts and each active longitude belts might be switch. Comparing the light curves of 2009 and 2010, it indicates that the light curve changes on a long time scale of one year, especially in phase 0.25. In addition, we also collected the values of the maximum amplitudes of photometric distortion of the short-period RS CVn binary. We found for the first time that there is a trend of increasin...

  3. Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection.

    Directory of Open Access Journals (Sweden)

    Janett Fischer

    Full Text Available BACKGROUND & AIMS: Genetic variations near the interferon lambda 3 gene (IFNL3, IL28B are the most powerful predictors for sustained virologic response (SVR in patients with chronic hepatitis C virus (HCV infection, compared to other biochemical or histological baseline parameters. We evaluated whether the interplay of both IFNL3 polymorphisms rs12979860 and rs8099917 together with non-genetic clinical factors contributes to the predictive role of these genetic variants. METHODS: The cohort comprised 1,402 patients of European descent with chronic HCV type 1 infection. 1,298 patients received interferon-based antiviral therapy, and 719 (55% achieved SVR. The IFNL3 polymorphisms were genotyped by polymerase chain reaction and melting curve analysis. RESULTS: A significant correlation was found between the IFNL3 polymorphisms and biochemical as well as virologic predictors of treatment outcome such as ALT, GGT, cholesterol, and HCV RNA levels. In multivariate regression analysis, IFLN3 SNPs, HCV RNA levels, and the GGT/ALT ratio were independent predictors of SVR. Dependent on the GGT/ALT ratio and on the HCV RNA concentration, significant variations in the likelihood for achieving SVR were observed in both, carriers of the responder as well as non-responder alleles. CONCLUSIONS: Our data support a clear association between IFNL3 genotypes and baseline parameters known to impact interferon responsiveness. Improved treatment outcome prediction was achieved when these predictors were considered in combination with the IFNL3 genotype.

  4. Duplex High-Resolution Melting Assay for the Simultaneous Genotyping of IL28B rs12979860 and PNPLA3 rs738409 Polymorphisms in Chronic Hepatitis C Patients

    Science.gov (United States)

    Enache, Elena L.; Sin, Anca; Bancu, Ligia; Ramière, Christophe; Diaz, Olivier; André, Patrice; Enache, Liviu S.

    2015-01-01

    Chronic hepatitis C (CHC) is a major burden for public health worldwide. Although newer direct-acting antivirals show good efficacy, their cost precludes their wide adoption in resource-limited regions. Thus, strategies are being developed to help identify patients with high susceptibility to response to classic PEG-interferon + ribavirin therapy. IL28B polymorphism rs12979860 C/T is an important predictor for an efficient response to interferon-based therapy. A genetic variant in adiponutrin (PNPLA3) gene, rs738409 C/G, is associated with steatosis, severity, and progression of liver fibrosis in CHC patients, and predicts treatment outcome in difficult-to-cure HCV-infected patients with advanced fibrosis. We developed a rapid and inexpensive assay based on duplex high-resolution melting (HRM) for the simultaneous genotyping of these two polymorphisms. The assay validation was performed on synthetic DNA templates and 132 clinical samples from CHC patients. When compared with allele-specific PCR and sequencing, our assay showed 100% (95% CI: 0.9724–1) accuracy, with 100% sensitivity and specificity. Our assay was robust against concentration and quality of DNA samples, melting curve normalization intervals, HRM analysis algorithm, and sequence variations near the targeted SNPs (single nucleotide polymorphism). This duplex assay should provide useful information for patient-oriented management and clinical decision-making in CHC. PMID:26389885

  5. Advancing the 3Rs in regulatory toxicology - Carcinogenicity testing: Scope for harmonisation and advancing the 3Rs in regulated sectors of the European Union.

    Science.gov (United States)

    Annys, Erwin; Billington, Richard; Clayton, Rick; Bremm, Klaus-Dieter; Graziano, Michael; McKelvie, Jo; Ragan, Ian; Schwarz, Michael; van der Laan, Jan Willem; Wood, Charles; Öberg, Mattias; Wester, Piet; Woodward, Kevin N

    2014-07-01

    Different government agencies operating in the European Union regulate different types of chemical products but all require testing for carcinogenicity to support applications for product marketing and commercialisation. A conference was held in Brussels in 2013 where representatives of the pharmaceutical, animal health, chemical and plant protection industries, together with representatives of regulatory agencies, universities and other stakeholders, met under the auspices of The European Partnership for Alternative Approaches to Animal Testing (EPAA) to discuss the varying requirements for carcinogenicity testing, and how these studies might be refined to improve hazard evaluation and risk assessment while implementing principles of the 3Rs (replacement, refinement and reduction in animal studies). While there are some similarities, the regulatory approaches in pharmaceutical, animal health, chemical and plant protection sectors have varying degrees of flexibility in requirements for carcinogenicity testing, to an extent reflecting concerns over the magnitude and duration of human exposure, either directly as in therapeutic exposure to pharmaceuticals, or indirectly through the ingestion of residues of veterinary drugs or plant protection chemicals. The article discusses these differences and other considerations for modified carcinogenicity testing paradigms on the basis of scientific and 3Rs approaches. PMID:24768934

  6. Conductor-Like Screening Model for Real Solvents (COSMO-RS)%真实溶剂似导体屏蔽模型(COSMO-RS)

    Institute of Scientific and Technical Information of China (English)

    牟天成; Jürgen Gmenhling

    2008-01-01

    真实溶剂似导体屏蔽模型(COSMO-RS, Conductor-like screening model for real solvents)是Klamt等在连续介质溶剂化模式COSMO的基础上,结合统计力学方法发展起来的定量计算溶剂化现象的新方法.本文简单介绍了COSMO-RS的基本原理、概念,以及应用该模式的基本步骤.综述了COSMO-RS应用于离子性化合物、聚合物溶液体系、高温高压体系以及预测复杂生物体系的分配系数和药物设计的进展.评述了简化分子表面屏蔽电荷分布计算的COSMOfrag和GC-COSMO (group contribution COSMO)方法,对不同版本的COSMO-RS之间以及其与基团贡献方法的对比研究也作了详细的讨论,并指出了COSMO-RS的不足之处和进一步发展该模式的建议.

  7. Down syndrome related muscle hypotonia: association with COL6A3 functional SNP rs2270669

    Directory of Open Access Journals (Sweden)

    Arpita eDey

    2013-04-01

    Full Text Available Down syndrome (DS, the principal cause for intellectual disability, is also associated with hormonal, immunological, and gastrointestinal abnormalities. Muscle hypotonia (MH and congenital heart diseases (CHD are also frequently observed. Collagen molecules are essential components for maintaining muscle integrity and are formed by the assembly of three chains, alpha 1-3. The type VI collagen is crucial for cardiac as well as skeletal muscles. The COL 1 (VI and 2 (VI chains are encoded by genes located at the 21st chromosome and are expected to have higher dosage in individuals with DS. The  3 (VI chain is encoded by the COL6A3 located at the chromosome 2. We hypothesized that apart from COL6A1 and COL6A2, COL6A3 may also have some role in the MH of subjects with DS. To find out the relevance of COL6A3 in DS associated MH and CHD, we genotyped two SNPs in COL6A3, rs2270669 and rs2270668, in individuals with DS. Subjects with DS were recruited based on the Diagnostic and Statistical Manual for Mental Disorders-IV and having trisomy of the 21st chromosome. Parents of individuals with DS and ethnically matched controls were enrolled for comparison. Informed written consent was obtained for participation. Peripheral blood was used for isolation of genomic DNA. Target genetic loci were studied by DNA sequence analysis. Data obtained was subjected to population- as well as family-based statistical analysis. rs2270668 was found to be nonpolymorphic in the studied population. rs2270669 showed significant association of the ‘C’ allele and ‘CC’ genotype with DS probands having MH (P=0.02. Computational analysis showed that rs2270669 may induce structural and functional alterations in the COL 3 (VI. Interaction of COL3 (VI with different proteins, crucial for muscle integrity, was also noticed by computational methods. This pioneering study on COL6A3 with DS related MH thus indicates that rs2270669 ‘C’ could be considered as a

  8. Prostate Cancer Susceptibility Polymorphism rs2660753 Is Not Associated with Invasive Ovarian Cancer

    DEFF Research Database (Denmark)

    Amankwah, Ernest K; Kelemen, Linda E; Wang, Qinggang;

    2011-01-01

    BACKGROUND: We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI=1.0-1.4, P(trend) = 0.01) that showed a stronger association with the serous histological subtype (OR = 1.3, 95% CI = 1.......1-1.5, P(trend) = 0.003). METHODS: We sought to replicate this association in 12 other studies comprising 4,482 cases and 6,894 controls of white non-Hispanic ancestry in the Ovarian Cancer Association Consortium. RESULTS: No evidence for an association with all cancers or serous cancers was observed.......0-1.2, P(trend) = 0.11). There was no evidence for statistical heterogeneity in ORs across the studies. CONCLUSIONS: Although rs2660753 is a strong prostate cancer susceptibility polymorphism, the association with another hormonally related cancer, invasive EOC, is not supported by this replication study...

  9. Prostate Cancer Susceptibility Polymorphism rs2660753 Is Not Associated with Invasive Ovarian Cancer

    DEFF Research Database (Denmark)

    Amankwah, Ernest K; Kelemen, Linda E; Wang, Qinggang;

    2011-01-01

    BACKGROUND: We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI=1.0-1.4, P(trend) = 0.01) that showed a stronger association with the serous histological subtype (OR = 1.3, 95% CI = 1.......0-1.2, P(trend) = 0.11). There was no evidence for statistical heterogeneity in ORs across the studies. CONCLUSIONS: Although rs2660753 is a strong prostate cancer susceptibility polymorphism, the association with another hormonally related cancer, invasive EOC, is not supported by this replication study.......1-1.5, P(trend) = 0.003). METHODS: We sought to replicate this association in 12 other studies comprising 4,482 cases and 6,894 controls of white non-Hispanic ancestry in the Ovarian Cancer Association Consortium. RESULTS: No evidence for an association with all cancers or serous cancers was observed...

  10. Convergence of FPR-rs3-expressing neurons in the mouse accessory olfactory bulb.

    Science.gov (United States)

    Dietschi, Quentin; Assens, Alexis; Challet, Ludivine; Carleton, Alan; Rodriguez, Ivan

    2013-09-01

    In the mouse, most members of the FPR receptor family are expressed by vomeronasal sensory neurons. The neural circuitry corresponding to this class of chemical sensors is unknown. Taking advantage of the presence of FPR-rs3 on both vomeronasal dendrites and axonal fibers, we visualized the distribution of sensory cells expressing this member of the FPR family, and their corresponding axonal projections in the olfactory bulb. We found a rostrocaudal gradient of receptor choice frequency in the vomeronasal sensory neuroepithelium, and observed a convergence of FPR-rs3 axons into multiple, linked and deeply located glomeruli. These were homogenously innervated, and spatially restricted to the basal portion of the rostral accessory olfactory bulb. This organization, reminiscent of the one that characterizes axonal projections of V1R-expressing neurons, supports a role played by these receptors in the perception of semiochemicals. PMID:23664818

  11. High-resolution optical spectroscopy of RS Ophiuchi during 2008 -- 2009

    CERN Document Server

    Somero, A; Wynn, G A

    2016-01-01

    RS Ophiuchi is a symbiotic variable and a recurrent nova. We have monitored it with the Nordic Optical Telescope and obtained 30 high resolution (R=46 000) optical spectra over one orbital cycle during quiescence. To our knowledge this is the best-sampled high resolution spectroscopic dataset of RS Oph over one orbital period. We do not detect any direct signatures of an accretion disc such as double peaked emission lines, but many line profiles are complex consisting of superimposed emission and absorption components. We measure the spin of the red giant and conclude that it is tidally locked to the binary orbit. We observe Na I absorption features, probably arising from the circumbinary medium, that has been shaped by previous recurrent nova outbursts. We do not detect any intrinsic polarisation in the optical wavelengths.

  12. Dynamical analysis of tRNA Gln-GlnRS complex using normal mode calculation

    Science.gov (United States)

    Nakamura, Shugo; Ikeguchi, Mitsunori; Shimizu, Kentaro

    2003-04-01

    We applied normal mode calculation in internal coordinates to a complex of glutamine transfer RNA (tRNA Gln) and glutaminyl-tRNA synthetase (GlnRS). Calculated deviations of atoms agreed well with those obtained from X-ray data. The differences of motions corresponding to low mode frequencies between the free state and the complex state were analyzed. For GlnRS, many motions in the free state were conserved in the complex state, while the dynamics of tRNA Gln was largely affected by the complex formation. Superimposed images of the conserved and non-conserved motions of tRNA Gln clearly indicated the restricted direction of motions in the complex.

  13. Konkursgäldenärs skiljeavtal : när binder avtalet konkursboet?

    OpenAIRE

    Persson, Emilia; Larsson, Nina

    2014-01-01

    Syftet med denna kandidatuppsats är att beskriva gällande rätt kring om och när en konkursgäldenärs skiljeavtal binder dess konkursbo samt konsekvenserna av detta. I dagsläget är rättsområdet osäkert och enbart grundat på praxis, uppsatsen utreder därför även om lagstiftning eller annan utveckling på området är erforderlig. Det har i praxis konstaterats att en konkursgäldenärs skiljeavtal binder dess konkursbo då tvister gäller obligationsrättsliga anspråk och bevakningsförfaranden är aktuell...

  14. Developments on the implementation of the Three Rs in research and education.

    Science.gov (United States)

    van Zutphen, L F; van der Valk, J B

    2001-01-01

    More than 40 years ago, Russell and Burch published their views on the implementation of the 'Three Rs' in animal experimentation. Since then, much has been achieved in this area. Recently, the European Science Foundation (ESF) has made a further step forward. In a position paper on the use of animals, ESF has formulated what it sees as prerequisites for the humane use of animals in research, testing and education. In this paper, we briefly report on these ESF guidelines. Also, an overview is presented on European legislative regulations for the (ethical) review of research protocols and for the education and training of persons involved in animal experiments. The great diversity between countries is illustrated with some examples and the need for harmonization is emphasised. The paper ends by highlighting the special role that editorial boards of journals can play in the further implementation of the Three Rs. PMID:11566596

  15. A Simple Scheme for Belief Propagation Decoding of BCH and RS Codes in Multimedia Transmissions

    Directory of Open Access Journals (Sweden)

    Marco Baldi

    2008-01-01

    Full Text Available Classic linear block codes, like Bose-Chaudhuri-Hocquenghem (BCH and Reed-Solomon (RS codes, are widely used in multimedia transmissions, but their soft-decision decoding still represents an open issue. Among the several approaches proposed for this purpose, an important role is played by the iterative belief propagation principle, whose application to low-density parity-check (LDPC codes permits to approach the channel capacity. In this paper, we elaborate a new technique for decoding classic binary and nonbinary codes through the belief propagation algorithm. We focus on RS codes included in the recent CDMA2000 standard, and compare the proposed technique with the adaptive belief propagation approach, that is able to ensure very good performance but with higher complexity. Moreover, we consider the case of long BCH codes included in the DVB-S2 standard, for which we show that the usage of “pure” LDPC codes would provide better performance.

  16. ANALYSIS OF SPECTRAL CHARACTERISTICS AMONG DIFFERENT SENSORS BY USE OF SIMULATED RS IMAGES

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This research, by use of RS image-simulating method, simulated apparent reflectance images at sensor level and ground-reflectance images of SPOT-HRV,CBERS-CCD,Landsat-TM and NOAA14-AVHRR' s corresponding bands. These images were used to analyze sensor's differences caused by spectral sensitivity and atmospheric impacts. The differences were analyzed on Normalized Difference Vegetation Index(NDVI). The results showed that the differences of sensors' spectral characteristics cause changes of their NDVI and reflectance. When multiple sensors' data are applied to digital analysis, the error should be taken into account. Atmospheric effect makes NDVI smaller, and atn~pheric correction has the tendency of increasing NDVI values. The reflectance and their NDVIs of different sensors can be used to analyze the differences among sensor' s features. The spectral analysis method based on RS simulated images can provide a new way to design the spectral characteristics of new sensors.

  17. Association study between the Taq1A (rs1800497 polymorphism and schizophrenia in a Brazilian sample

    Directory of Open Access Journals (Sweden)

    Quirino Cordeiro

    2014-08-01

    Full Text Available Schizophrenia is a severe psychotic disorder with recurrent relapse and functional impairment. It results from a poorly understood gene-environment interaction. The Taq1A polymorphism (located in the gene cluster NTAD is a likely candidate for schizophrenia. Its rs1800497 polymorphism was shown to be associated with DRD2 gene expression. Therefore the present work aims to investigate a possible association between schizophrenia and such polymorphism. The compared distribution of the alleles and genotypes of the studied polymorphism was investigated in a Brazilian sample of 235 patients and 834 controls. Genotypic frequencies were in Hardy-Weinberg equilibrium. There was a trend of allelic association between the Taq1A polymorphism (rs1800497 with schizophrenia in the studied sample. However no statistically differences were found between cases and controls when analyzed by gender or schizophrenia subtypes.

  18. Promoting the 3Rs to enhance the OECD fish toxicity testing framework.

    Science.gov (United States)

    Hutchinson, Thomas H; Wheeler, James R; Gourmelon, Anne; Burden, Natalie

    2016-04-01

    Fish toxicity testing has been conducted since the 1860's in order to help define safe levels of chemical contaminants in lakes, rivers and coastal waters. The historical emphasis on acute lethality testing of chemicals has more recently focussed on long term sublethal effects of chemicals on fish and their prey species. Fish toxicity testing is now embedded in much environment legislation on chemical safety while it is recognized that animal use should be Replaced, Reduced and Refined (the 3Rs) where possible. The OECD Fish Toxicity Testing Framework provides a useful structure with which to address the needs of environmental safety assessment whilst implementing the 3Rs. This commentary aims to promote the implementation of the recommendations of the OECD Fish Toxicity Testing Framework. PMID:26873775

  19. A survey of knowledge of the three Rs concept among lecturers and postgraduate students in Brazil.

    Science.gov (United States)

    Tréz, de A Thales

    2014-05-01

    The use of animals in science is a widespread practice, despite growing concern about its moral justification and scientific relevance. In this scenario, the Three Rs concept might be considered to be a motivation for the establishment of a new scientific approach to the use of experimental animals and to research itself. The main objective of this survey-based study was to identify the level of knowledge about this concept among lecturers (i.e. tenure-track professors) and postgraduate students in the physiological and pharmaceutical sciences in Brazilian universities. A questionnaire was completed by 185 lecturers from 16 universities, and 140 postgraduate students from five of these universities. The results indicate that the concept of the Three Rs is widespread among lecturers and students in the areas of physiology and pharmacology, throughout Brazilian universities, but that its interpretation generally attributes more importance to refinement than to reduction and replacement. PMID:24901906

  20. MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis

    Directory of Open Access Journals (Sweden)

    Sergio Rodriguez-Cuevas

    2012-01-01

    Full Text Available MicroRNAs (miRNAs are small non-coding RNAs of ~22 nucleotides that function as negative regulators of gene expression by either inhibiting translation or inducing deadenylation-dependent degradation of target transcripts. Notably, deregulation of miRNAs expression is associated with the initiation and progression of human cancers where they act as oncogenes or tumor suppressors contributing to tumorigenesis. Abnormal miRNA expression may provide potential diagnostic and prognostic tumor biomarkers and new therapeutic targets in cancer. Recently, several miRNAs have been shown to initiate invasion and metastasis by targeting multiple proteins that are major players in these cellular events, thus they have been denominated as metastamiRs. Here, we present a review of the current knowledge of miRNAs in cancer with a special focus on metastamiRs. In addition we discuss their potential use as novel specific markers for cancer progression.

  1. The NOD2 p.Leu1007fsX1008 mutation (rs2066847 is a stronger predictor of the clinical course of Crohn's disease than the FOXO3A intron variant rs12212067.

    Directory of Open Access Journals (Sweden)

    Fabian Schnitzler

    Full Text Available BACKGROUND: Very recently, a sub-analysis of genome-wide association scans revealed that the non-coding single nucleotide polymorphism (SNP rs12212067 in the FOXO3A gene is associated with a milder course of Crohn's disease (CD (Cell 2013;155:57-69. The aim of our study was to evaluate the clinical value of the SNP rs12212067 in predicting the severity of CD by correlating CD patient genotype status with the most relevant complications of CD such as stenoses, fistulas, and CD-related surgery. METHODOLOGY/PRINCIPAL FINDINGS: We genotyped 550 CD patients for rs12212067 (FOXO3A and the three common CD-associated NOD2 mutations rs2066844, rs2066847, and rs2066847 and performed genotype-phenotype analyses. RESULTS: No significant phenotypic differences were found between the wild-type genotype TT of the FOXO3A SNP rs12212067 and the minor genotypes TG and GG independently from NOD2 variants. The allele frequency of the minor G allele was 12.7%. Age at diagnosis, disease duration, body mass index, surgery rate, stenoses, fistula, need for immunosuppressive therapy, and disease course were not significantly different. In contrast, the NOD2 mutant p.Leu1007fsX1008 (rs2066847 was highly associated with penetrating CD (p = 0.01, the development of fistulas (p = 0.01 and stenoses (p = 0.01, and ileal disease localization (p = 0.03. Importantly, the NOD2 SNP rs2066847 was a strong separator between an aggressive and a mild course of CD (p = 2.99×10(-5, while the FOXO3A SNP rs12212067 did not separate between mild and aggressive CD behavior in our cohort (p = 0.35. 96.2% of the homozygous NOD2 p.Leu1007fsX1008 carriers had an aggressive disease behavior compared to 69.3% of the patients with the NOD2 wild-type genotype (p = 0.007. CONCLUSION/SIGNIFICANCE: In clinical practice, the NOD2 variant p.Leu1007fsX1008 (rs2066847, in particular in homozygous form, is a much stronger marker for a severe clinical phenotype than the FOXO3A

  2. Individual differences in allocation of funds in the dictator game associated with length of the arginine vasopressin 1a receptor RS3 promoter region and correlation between RS3 length and hippocampal mRNA.

    Science.gov (United States)

    Knafo, A; Israel, S; Darvasi, A; Bachner-Melman, R; Uzefovsky, F; Cohen, L; Feldman, E; Lerer, E; Laiba, E; Raz, Y; Nemanov, L; Gritsenko, I; Dina, C; Agam, G; Dean, B; Bornstein, G; Ebstein, R P

    2008-04-01

    Human altruism is a widespread phenomenon that puzzled evolutionary biologists since Darwin. Economic games illustrate human altruism by showing that behavior deviates from economic predictions of profit maximization. A game that most plainly shows this altruistic tendency is the Dictator Game. We hypothesized that human altruistic behavior is to some extent hardwired and that a likely candidate that may contribute to individual differences in altruistic behavior is the arginine vasopressin 1a (AVPR1a) receptor that in some mammals such as the vole has a profound impact on affiliative behaviors. In the current investigation, 203 male and female university students played an online version of the Dictator Game, for real money payoffs. All subjects and their parents were genotyped for AVPR1a RS1 and RS3 promoter-region repeat polymorphisms. Parents did not participate in online game playing. As variation in the length of a repetitive element in the vole AVPR1a promoter region is associated with differences in social behavior, we examined the relationship between RS1 and RS3 repeat length (base pairs) and allocation sums. Participants with short versions (308-325 bp) of the AVPR1a RS3 repeat allocated significantly (likelihood ratio = 14.75, P = 0.001, df = 2) fewer shekels to the 'other' than participants with long versions (327-343 bp). We also implemented a family-based association test, UNPHASED, to confirm and validate the correlation between the AVPR1a RS3 repeat and monetary allocations in the dictator game. Dictator game allocations were significantly associated with the RS3 repeat (global P value: likelihood ratio chi(2) = 11.73, df = 4, P = 0.019). The association between the AVPR1a RS3 repeat and altruism was also confirmed using two self-report scales (the Bardi-Schwartz Universalism and Benevolence Value-expressive Behavior scales). RS3 long alleles were associated with higher scores on both measures. Finally, long AVPR1a RS3 repeats were associated with

  3. Vitamin D3 receptor ( VDR gene rs2228570 (Fok1 and rs731236 (Taq1 variants are not associated with the risk for multiple sclerosis: results of a new study and a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Elena García-Martín

    Full Text Available BACKGROUND: Some epidemiological, genetic, and experimental data suggest a possible role of vitamin D in the pathogenesis of multiple sclerosis (MS and in experimental autoimmune encephalomyelitis. Data on the possible contribution of several single nucleotide polymorphisms (SNP in the vitamin D receptor (VDR gene to the risk for MS are controversial. Several studies suggested an interaction between some SNPs in the VDR gene and HLADRB1*1501 in the risk for MS. OBJECTIVES: The aim of this study was to investigate a possible influence of the SNPs rs2228570 and rs731236 in the VDR gene in the risk for MS. A secondary objective was to address the possible interactions between VDR genes and HLADRB1*1501. METHODS: We analyzed the allelic and genotype frequency of VDR rs2228570, rs731236, and HLADRB1*1501 (rs3135388 in 303 patients with MS and 310 healthy controls, using TaqMan Assays. We also conducted a meta-analysis, that was carried out by using the software Meta-Disc 1.1.1 (http://www.hrc.es/investigacion/metadisc.html; Unit of Clinical Statistics, Hospital Ramón y Cajal, Madrid, Spain. Heterogeneity between studies in terms of degree of association was tested using the Q-statistic. RESULTS: VDR rs2228570 and rs731236 allelic and genotype frequencies did not differ significantly between MS patients and controls, and were unrelated with the age of onset of MS, gender, and course of MS. HLADRB1*1501 showed a high association with the risk of developing MS 4.76(95% C.I.  = 3.14-7.27; p<0.0001. The meta-analysis, after excluding data of one study that was responsible of heterogeneity for rs731236 polymorphism, showed lack of relation of both SNPs with the risk for MS. HLADRB1*1501 showed lack of interaction with VDR rs2228570 and rs731236 in increasing MS risk. CONCLUSIONS: These results suggest that VDR rs2228570 and rs731236 polymorphisms are not related with the risk for MS, and did not confirm interaction between these VDR SNPs and HLADRB1

  4. Oral health in institucionalizated elderly patients in two care centers in Passo Fundo - RS

    OpenAIRE

    Nicolau Silveira Neto; João Paulo de Carli; Maria Salete Sandini Linden; Micheline Sandini Trentin; Soluete Oliveira da Silva; Luciele Raquel Luft

    2008-01-01

    Objective: Considering that oral health, as well as general health are fundamental for maintaining the quality of life, the objective of this study was to investigate the oral health of the elderly population in the São José and Nossa Senhora da Luz Care Centers in Passo Fundo/ RS, Brazil. Methods: a clinical examination was performed in 107 elderly patients, to evaluate the oral health status as regards periodontal disease, edentulism, physiological alterations, and mucosa infection by the C...

  5. A Simple Voltage Controlled Oscillator Using Bootstrap Circuits and NOR-RS Flip Flop

    Science.gov (United States)

    Chaikla, Amphawan; Pongswatd, Sawai; Sasaki, Hirofumi; Fujimoto, Kuniaki; Yahara, Mitsutoshi

    This paper presents a simple and successful design for a voltage controlled oscillator. The proposed circuit is based on the use of two identical bootstrap circuits and a NOR-RS Flip Flop to generate wide-tunable sawtooth and square waves. Increasing control voltage linearly increases the output oscillation frequency. Experimental results verifying the performances of the proposed circuit are in agreement with the calculated values.

  6. ROBOTIC FORK-LIFT AUTOMATED STORAGE AND RETRIEVAL SYSTEM (AS/RS)

    OpenAIRE

    S.U.CHAKOLE; G.H. WAGHMARE

    2013-01-01

    The automated storage and retrieval systems (AS/RS) are major material handling support systems that are commonly used in the automated factories, distribution centers, warehousing, and non manufacturing environments. Their applications vary widely from a simple storage and retrieval system for small parts to central systems where production, assembly, and manufacturing operations are concentrically located around them. This paper summarizes the literature study of a Robotic automated storage...

  7. VHR Image Specifications for the CwRS Programme Campaign 2009

    OpenAIRE

    AASTRAND Paer; ERLANDSSON Maria

    2009-01-01

    This document constitutes the specifications for VHR imagery to be used within the CwRS Programme. Its objective is to give the stakeholders in the image acquisition management chain clarity in the technical details of the process and describes the process flow starting from zone definition, through the image use, reaching image return and possible re-use of imagery at end of Campaign

  8. Differential expression patterns of conserved miRNAs and isomiRs during Atlantic halibut development

    Directory of Open Access Journals (Sweden)

    Bizuayehu Teshome T

    2012-01-01

    Full Text Available Abstract Background MicroRNAs (miRNAs play a major role in animal ontogenesis. Size variants of miRNAs, isomiRs, are observed along with the main miRNA types, but their origin and possible biological role are uncovered yet. Developmental profiles of miRNAs have been reported in few fish species only and, to our knowledge, differential expressions of isomiRs have not yet been shown during fish development. Atlantic halibut, Hippoglossus hippoglossus L., undergoes dramatic metamorphosis during early development from symmetrical pelagic larval stage to unsymmetrical flatfish. No data exist on role of miRNAs in halibut metamorphosis. Results miRNA profiling using SOLiD deep sequencing technology revealed a total of 199 conserved, one novel antisense, and one miRNA* mature form. Digital expression profiles of selected miRNAs were validated using reverse transcription quantitative PCR. We found developmental transition-specific miRNA expression. Expression of some miRNA* exceeded the guide strand miRNA. We revealed that nucleotide truncations and/or additions at the 3' end of mature miRNAs resulted in size variants showing differential expression patterns during the development in a number of miRNA families. We confirmed the presence of isomiRs by cloning and Sanger sequencing. Also, we found inverse relationship between expression levels of sense/antisense miRNAs during halibut development. Conclusion Developmental transitions during early development of Atlantic halibut are associated with expression of certain miRNA types. IsomiRs are abundant and often show differential expression during the development.

  9. Hubble Space Telescope Imaging of the Expanding Nebular Remnant of the 2006 Outburst of RS Ophiuchi

    CERN Document Server

    Harman, D J; Darnley, M J; O'Brien, T J; Bond, H E; Starrfield, S; Evans, A; Eyres, S P S; Ribeiro, V A R M; Echevarria, J M

    2008-01-01

    We report {\\it Hubble Space Telescope} imaging obtained 155 days and 449 days after the 2006 outburst of RS Ophiuchi. Both epochs show evidence of extended emission, consistent with that seen in earlier radio observations, and a maximum expansion rate of $3200\\pm300$ km s$^{-1}$ (in the plane of the sky). The extended structure is consistent with the remnant having a bipolar morphology with an inclination similar to that determined for the binary.

  10. The Method and Key Technology of Dynamic RS-GIS Environment Monitoring

    Science.gov (United States)

    Chen, Jianping; Xiang, Jie; Tarolli, Paolo; Lai, Zili

    2016-04-01

    Demographic growth, socio-economic development and urbanization have resulted in excessive exploitation and exerted increasing pressure on limited resources and the fragile ecological environment in China. There is an urgent need for theory and technology to achieve the comprehensive evaluation of environment. Remote sensing is one of the most important technology to monitor and evaluate environment. This study summed up dynamic RS (Remote Sensing)-GIS (Geographic Information System) environment monitoring theory, and established a dynamic monitoring system, adopting comprehensive methods of multi-source, multi-scale and multi-temporal remote sensing data acquisition. A software system is developed based on RS-GIS analysis method to support the whole dynamic monitoring and evaluation theory. The main work and results obtained are as follows: 1)Summarized the evaluation theory of dynamic RS-GIS environment monitoring, using remote sensing technology as the main method to monitor environment; 2) established an advanced space-air-ground digital terrain data acquisition and processing technology (advanced satellite constellations, airborne and terrestrial laser scanner, low-cost Structure from Motion (SfM), photogrammetry, Unmanned Aerial Vehicle (UAV) and ground camera surveys); 3) Deeply study the application of quantitative digital terrain analysis in the assessment of environment, which successfully position geological disaster information and automatically extracted information; 4) Developed the RESEE software to support the whole dynamic monitoring and evaluation theory based on 4D-GIS; 5) A demonstration study of the dynamic monitoring environment is carried out in Beijing Miyun Iron Mine. Results show that the space-air-ground integrated and dynamic RS-GIS environment monitoring method and key technology can realize the positioning and quantitative monitoring the environment problem, and realize the risk assessment of the geological hazard.

  11. Evaluation of two Vaisala RS92 radiosonde solar radiative dry bias correction algorithms

    OpenAIRE

    Dzambo, Andrew M.; Turner, David D.; Mlawer, Eli J.

    2016-01-01

    Solar heating of the relative humidity (RH) probe on Vaisala RS92 radiosondes results in a large dry bias in the upper troposphere. Two different algorithms (Miloshevich et al., 2009, MILO hereafter; and Wang et al., 2013, WANG hereafter) have been designed to account for this solar radiative dry bias (SRDB). These corrections are markedly different with MILO adding up to 40 % more moisture to the original radiosonde profile than WANG; however, the impact of the two algo...

  12. Evaluation of two Vaisala RS92 radiosonde solar radiative dry bias correction algorithms

    OpenAIRE

    A. M. Dzambo; D. D. Turner; E. J. Mlawer

    2015-01-01

    Solar heating of the relative humidity (RH) probe on Vaisala RS92 radiosondes results in a large dry bias in the upper troposphere. Two different algorithms (Miloshevich et al., 2009, MILO hereafter; and Wang et al., 2013, WANG hereafter) have been designed to account for this solar radiative dry bias (SRDB). These corrections are markedly different with MILO adding up to 40 % more moisture to the original radiosonde profile than WANG; however, the impact of the two algori...

  13. Bacillus anthracis HssRS signaling to HrtAB regulates heme resistance during infection

    OpenAIRE

    Stauff, Devin L; Skaar, Eric P.

    2009-01-01

    Bacillus anthracis proliferates to high levels within vertebrate tissues during the pathogenesis of anthrax. This growth is facilitated by the acquisition of nutrient iron from host heme. However, heme acquisition can lead to the accumulation of toxic amounts of heme within B. anthracis. Here, we show that B. anthracis resists heme toxicity by sensing heme through the HssRS two-component system, which regulates expression of the heme-detoxifying transporter HrtAB. In addition, we demonstrate ...

  14. EURL ECVAM strategy for achieving 3Rs impact in the assessment of toxicokinetics and systemic toxicity

    OpenAIRE

    BESSEMS JOSEPH; Coecke, Sandra; GOULIARMOU VARVARA; Whelan, Maurice; Worth, Andrew

    2015-01-01

    Information on human toxicokinetics plays an important role in the safety assessment of chemicals, even though there are few data requirements in the EU regulatory framework. While existing EU test methods and OECD test guidelines are mostly based on animal procedures, there are increasing opportunities to achieve a 3Rs impact in this area by exploiting modern developments. For example, whole-body toxicokinetic information can be obtained by using physiologically-based toxicokinetic (PBTK) mo...

  15. Overview of the ARIES-RS reversed-shear tokamak power plant study

    International Nuclear Information System (INIS)

    The ARIES-RS tokamak is a conceptual, D-T-burning 1000 MWe power plant. As with earlier ARIES design studies, the final design of ARIES-RS was obtained in a self-consistent manner using the best available physics and engineering models. Detailed analyses of individual systems together with system interfaces and interactions were incorporated into the ARIES systems code in order to assure self-consistency and to optimize towards the lowest cost system. The ARIES-RS design operates with a reversed-shear plasma and employs a moderate aspect ratio (A=4.0). The plasma current is relatively low (Ip=11.32 MA) and bootstrap current fraction is high (fBC=0.88). Consequently, the auxiliary power required for RF current drive is relatively low (∝80 MW). At the same time, the average toroidal beta is high (β=5%), providing power densities near practical engineering limits (the peak neutron wall loading is 5.7 MW m-2). The toroidal-field (TF) coil system is designed with relatively 'conventional' materials (Nb3Sn and NbTi conductor with 316SS structures), and is operated at a design limit of ∝16 T at the coil in order to optimize the design point. The ARIES-RS design uses a self-cooled lithium blanket with vanadium alloy as the structural material. The V-alloy has low activation, low afterheat, high temperature capability and can handle high heat flux. A self-cooled liquid lithium blanket is simple, and with the development of an insulating coating, has low operating pressure. Also, this blanket gives excellent neutronics performance. Detailed analysis has been performed to minimize the cost and maximize the performance of the blanket and shield. (orig.)

  16. Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome.

    Directory of Open Access Journals (Sweden)

    Tao Li

    Full Text Available BACKGROUND: Fat mass and obesity-associated gene (FTO has been associated with obesity, especially the common variant rs9939609. Polycystic ovary syndrome (PCOS is a complex endocrine-metabolic disorder and over 50% of patients are overweight/obese. Thus FTO is a potential candidate gene for PCOS but their relationship is confusing and remains to be clarified in different population with a large sample size. METHOD: This study was performed adopting a two-stage design by genotyping SNP rs9939609. The first set comprise of 741 PCOS and 704 control subjects, with data from our previous GWAS. The second phase of replication study was performed among another independent group of 2858 PCOS and 2358 control subjects using TaqMan-MGB probe assay. All subjects are from Han Chinese. RESULTS: The less meaningful association of FTO rs9939609 and PCOS discovered in GWAS (P = 2.47E-03, was further confirmed in the replication study (P = 1.86E-09. Using meta-analysis, the P-meta value has reached 6.89E-12, over-exceeding the genome-wide association level of 5.00E-8. By combination, the P value was 1.26E-11 and after BMI adjustment it remained significant(P = 1.82E-06. To further elucidate whether this association is resulted from obesity or PCOS per se, the samples were divided into two groups-obese and non-obese PCOS, and the results were still positive in obese group (P obese = 5.81E-05, OR = 1.55, as well as in non-obese PCOS group (P non-obese = 7.06E-04, OR = 1.28. CONCLUSION: Variant rs9939609 in FTO is associated with PCOS in Chinese women, not only in obese PCOS subjects, but also in non-obese cases.

  17. Analysis on Ecological Sensitivity in Jinjie Mining Area Based on RS and GIS

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    [Objective] The aim was to study ecological sensitivity in Jinjie mining area. [Method] Taking Jinjie mining area as study object, based on RS and GIS technology, ecological sensitivity in Jinjie mining area was assessed comprehensively from the aspects of soil erosion, desertification and geological disaster by means of multivariate weighted stack method. [Result] Most of Jinjie mining area belonged to extremely high sensitive or high sensitive area which accounted for 73.35% of total area, with little mod...

  18. Rotational modulation and flares on RS Canum Venaticorum and BY Draconis stars. 18: Coordinated VLA, ROSAT, and IUE observations of RS CVn binaries

    Science.gov (United States)

    Fox, David C.; Linsky, Jeffrey L.; Veale, Anthony; Dempsey, Robert C.; Brown, Alex; Neff, James E.; Pagano, Isabella; Rodono, Marcello; Bromage, Gordon E.; Kuerster, Martin

    1994-01-01

    As part of a coordinated program of multi-wavelength observations of RS CVn close binary systems, we observed 15 systems with the Very Large Array (VLA) and 10 systems with IUE, simultaneously or nearly simultaneously with the ROSAT All Sky Survey observations of these stars. Of the 22 systems observed with ROSAT, three were observed both by IUE and the VLA. Radio observations were made at 3.6, 6 and 20 cm. Of the 15 observed RS CVn systems, we detected 11 with greater than 4 sigma confidence at one or more wavelengths. The IUE observations were made within the RIASS (ROSAT-IUE All Sky Survey) program. We present the results of the VLA observations, along with the corresponding subsets of the ROSAT Position Sensitive Proportional Counter (PSPC) X-ray and Wide Field Camera (WFC) XUV survey, and RIASS IUE observations. We obtained an extended VLA/IUE/ROSAT simultaneous coverage of one system, TY Pyx, covering more than one orbital period. These observations reveal that the quiescent radio flux of TY Pyx is relatively constant over time scales of up to 7 hours, but that it did change by a factor of 3 over 24 hours, probably due to a flare on 1990 Nov. 12. The UV, XUV and X-ray fluxes do not show large day-to-day or phase-related variability. The observation of the decay phase of a radio flare on EI Eri, with no accompanying X-ray or XUV flare, suggests that the lack of a strong correlation between X-ray and radio flares previously noted for dMe flare stars holds for RS CVn systems as well. We suggest that the radio flare may have been due to a coherent emission process such as electron cyclotron emission. The simultaneous measurements presented here provide a unique test of the general correlation between radio and soft X-ray luminosities, L(sub radio) approximately L(sub x exp m) (Drake et al. 1989) with a power-law slope close to unity, which was previously derived using data obtained years apart. Our derived slopes are consistent with and thus support the general

  19. Study of Association between Interleukin 20 Polymorphism (Rs1518108 and Chronic Hepatitis C Infection

    Directory of Open Access Journals (Sweden)

    Elham Arbabi-Aval

    2013-07-01

    Full Text Available Background: Chronic hepatitis C is a major concern for global health as it causes liver problems, cirrhosis and liver cancer. Immune factors have a determinant role in susceptibility to chronic infection or clearance of infection in body. As a defensive agent, cytokines are important factors of immune system, since they can activate immune response or inhibit virus replication directly. The aim of this study is the evaluation of interleukin 20 polymorphism (rs1518108 in hepatitis C patients.Materials and Methods: This survey was a case–control study. By using PCR-RFLP method, 105 patients and 135 controls were studied randomly. We used SPSS-16 software for statistical analysis.Results: A significant association was found between polymorphism (rs1518108 of interleukin 20 and hepatitis C patients (p=0.035 (OR=2.283. The incidence of hepatitics C in males was observed five times more than that one females (p=0.01 (OR=5.18. In addition, no significant association between polymorphism of genotypes and liver harms (chronic and cirrhosis was found in this study (p=0.362.Conclusion: Our findings show that variants of interleukin 20 polymorphism (rs1518108 in the population of the study are important factors for being affected by hepatitis C. The incidence of heterozygote allele CT was more than of homozygote genotype TT.

  20. The evolution of animal welfare and the 3Rs in Brazil, China, and India.

    Science.gov (United States)

    Bayne, Kathryn; Ramachandra, Gudde S; Rivera, Ekaterina A; Wang, Jianfei

    2015-03-01

    Increasingly, scientific collaborations and contracts cross country borders. The need for assurance that the quality of animal welfare and the caliber of animal research conducted are equivalent among research partners around the globe is of concern to the scientific and laboratory animal medicine communities, the general public, and other key stakeholders. Therefore, global harmonization of animal care and use standards and practices, with the welfare of the animals as a cornerstone, is essential. In the evolving global landscape of enhanced attention to animal welfare, a widely accepted path to achieving this goal is the successful integration of the 3Rs in animal care and use programs. Currently, awareness of the 3Rs, their implementation, and the resulting animal care and use standards and practices vary across countries. This variability has direct effects on the animals used in research and potentially the data generated and may also have secondary effects on the country's ability to be viewed as a global research partner. Here we review the status of implementation of the 3Rs worldwide and focus on 3 countries-Brazil, China and India-with increasing economic influence and an increasing footprint in the biomedical research enterprise.

  1. The effect of observing session duration on OPUS-RS results

    Science.gov (United States)

    Dincer Dogru, A.; Ugur Sanli, D.; Hayal, Adem G.; Berber, Mustafa

    2016-04-01

    Online GPS positioning software has now a widespread interest among practitioners and researchers. Researchers rescently use online software to monitor natural hazards such as landslides. The fact that this software usually employs continuously operating GPS stations of the International GNSS Service (IGS) as reference stations in the processing, the community of world-wide users is growing day by day. In the monitoring of landslides, rapid static mode of a GPS surveying is usually preferred because it is possible to have wider field coverage with only a few minutes of data and low cost ground markers. Results comparable to static positioning can be obtained with careful network design and processing strategies. Some online software such as OPUS-RS developed by the National Geodetic Survey (NGS) of the USA provides rapid static positioning engine that processes GPS data from sessions of only a few minutes. 15-minute is the recommended/standard observing session duration for OPUS-RS processing. In this study, using the CORS data operating in the US, we carried out some tests in which the observing session duration is changed from 8 through 118 minutes, and observed the accuracy change on the OPUS-RS solutions. Then we compared the results with the accuracy levels given for 15-min solutions by the NGS. We determined that there is the effect of changing observing session duration on the obtained results, and we report them in this study.

  2. PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder.

    Science.gov (United States)

    Schuhmacher, Anna; Mössner, Rainald; Höfels, Susanne; Pfeiffer, Ute; Guttenthaler, Vera; Wagner, Michael; Schwab, Sibylle G; Maier, Wolfgang; Zobel, Astrid

    2011-03-01

    Variant rs2522833 of the Piccolo-encoding gene PCLO has recently been found to be associated with major depressive disorder (MDD). PCLO encodes a presynaptic cytomatrix protein which influences monoamine neurotransmitter release. Piccolo could therefore play an important role in treatment response to antidepressant therapy and the improvement of alterations in HPA system reactivity. We investigated the influence of the coding variant rs2522833 in the PCLO gene on treatment response in 205 in-patients with unipolar depression. Treatment response was measured (1) at the level of psychopathology using the Hamilton Depression Rating Scale (HAMD) and (2) with the combined dexamethasone/corticotropin-releasing hormone (Dex/CRH) test, which is a refined tool for showing dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) system, a neurobiological finding in depression. While we did not find an association between variation in PCLO and HAMD scores, HPA dysregulation was less pronounced in carriers of the AA genotype than in carriers of one or two C alleles. HPA activity of individuals with the AA genotype only marginally changed during 4-wk antidepressant treatment, whereas C allele carriers showed a higher hormonal secretion at admission than carriers of the AA genotype but lower responsivity to the Dex/CRH challenge after 4 wk. Our results point to a moderating role of PCLO SNP rs2522833 on HPA regulation during antidepressant treatment, which may represent a neurobiological feature of stability of clinical response.

  3. PREPARATION AND CELL COMPATIBILITY OF FUNCTIONALIZED BIODEGRADABLE POLY(DL-LACTIDE-CO-RS-Β-MALIC ACID)

    Institute of Scientific and Technical Information of China (English)

    Kui-lin Lai; Bin He; Zhong-wei Gu

    2008-01-01

    In order to create a functionalized biodegradable polymer for vascular tissue engineering application, poly(DL-lactide-co-RS-β-malic acid) (PDLLMAc) was synthesized. PDLLMAc was obtained after hydrogenolysis of poly(DL-lactide-co-RS-β-benzyl malolactonate) (PDLLMA), which was from the ring-opening polymerization of DL-lactide (DLLA)and RS-β-benzyl malolactonate (MA) using stannous octoate as catalyst. The copolymers were characterized by 1H-NMR,FTIR, GPC and DSC. The tensile strength and water uptake of the copolymers were measured. In copolymerization, theproportion of MA in the derived copolymers was lower than that in the feeding dose, a consequence of its lower reactivity.The molecular weight of the copolymers decreased with increasing MA content. The protective benzyl groups werecompletely removed in hydrogenolysis. The glass transition temperature (Tg) of the protected copolymers decreased withincreasing MA content. The mechanical strength test showed that the tensile strength of PDLLMA decreased whileelongation increased with MA content increasing, and the tensile strength increased and elongation decreased with increasingmalic acid content in PDLLMAc for the formation of hydrogen bonding. The water uptake showed that more hydrophilicmalic acid adsorbed more water in PDLLMAc. In order to test the reactivity of functional pendant groups, bioactive RGDpeptide was immobilized on the functionalized polymer film surface and smooth muscle cells (SMCs) were cultured on it.The results showed that the functionalized copolymer was biocompatible and could be potentially applied in vascular tissueengineering.

  4. rs6295 [C]-Allele Protects Against Depressive Mood in Elderly Endurance Athletes.

    Science.gov (United States)

    Haslacher, Helmuth; Michlmayr, Matthias; Batmyagmar, Delgerdalai; Perkmann, Thomas; Ponocny-Seliger, Elisabeth; Scheichenberger, Vanessa; Scherzer, Thomas M; Nistler, Sonja; Pilger, Alexander; Dal-Bianco, Peter; Lehrner, Johann; Pezawas, Lukas; Wagner, Oswald F; Winker, Robert

    2015-12-01

    A single nucleotide variant within the promoter of the 5-hydroxytryptamine1A (5HT1A) receptor, rs6295, is part of a binding site for the transcription factor. We aimed to ascertain whether the rs6295 mediates the effect of exercise on depressive mood in elderly endurance athletes. We prospectively enrolled 55 elderly athletes (marathon runners/bicyclists) and 58 controls. In a controlled, univariate model, an interaction between the [C]-allele and physical activity indicated that only among athletes, the variant resulting in an imperfect NUDR binding site was associated with a lower depression score. Hence, athletes presented with a significantly lower relative risk of achieving a suspicious depression score among carriers of at least one [C]-allele. Our results suggest that the positive effect of physical exercise on depressive mood might be mediated by the 5HT1A receptor and the extent of this protective effect seems to be enhanced by the [C]-allele of the rs6295 variant.

  5. Performance evaluation of Eureka-147 with RS(204, 188) code for mobile multimedia broadcasting

    Science.gov (United States)

    Chang, Seung-Gi; Ha, Victor H. S.; Zhang, Zhiming; Kim, Yongje

    2003-06-01

    The demand for mobile multimedia broadcasting service is increasing consistently as more people expect seamless outdoor connections and communication capabilities. In this paper, we introduce the digital multimedia broadcasting (DMB) system based on Eureka-147 that has been tentatively adopted in Korea. Since Eureka-147 is originally designed for broadcasting digital audio data, it provides a bit error rate (BER) of about 10-4 while the transmission of compressed video data, for example, requires the BER of about 10-9. To deal with this mismatch, the Korean DMB standard is considering the addition of the RS(204,188) coder to Eureka-147. In this paper, we apply the RS(204,188) coder to the Eureka-147 and present the simulation results on the performance of this modified system at various transmission and protection modes. We conclude that the addition of RS(204,188) coder to Eureka-147 in the Korean DMB system results in the satisfactory level of BER for mobile multimedia broadcasting services.

  6. (R,S)-2-chlorophenoxyl pyrazolides as novel substrates for improving lipase-catalyzed hydrolytic resolution.

    Science.gov (United States)

    Kao, Min-fang; Lu, Pei-yu; Kao, Jou-yan; Wang, Pei-yun; Wu, An-chi; Tsai, Shau-Wei

    2012-01-01

    The best reaction condition of Candida antartica lipase B as biocatalyst, 3-(2-pyridyl)pyrazole as leaving azole, and water-saturated methyl t-butyl ether as reaction medium at 45°C were first selected for performing the hydrolytic resolution of (R,S)-2-(4-chlorophenoxyl) azolides (1-4). In comparison with the kinetic resolution of (R,S)-2-phenylpropionyl 3-(2-pyridyl)pyrazolide or (R,S)-α-methoxyphenylacetyl 3-(2-pyridyl)pyrazolide at the same reaction condition, excellent enantioselectivity with more than two order-of-magnitudes higher activity for each enantiomer was obtained. The resolution was then extended to other (R,S)-3-(2-pyridyl)pyrazolides (5-7) containing 2-chloro, 3-chloro, or 2,4-dichloro substituent, giving good (E > 48) to excellent (E > 100) enantioselectivity. The thermodynamic analysis for 1, 2, and 4-7 demonstrates profound effects of the acyl or leaving moiety on varying enthalpic and entropic contributions to the difference of Gibbs free energies. A thorough kinetic analysis further indicates that on the basis of 6, the excellent enantiomeric ratio for 4 and 7 is due to the higher reactivity of (S)-4 and lower reactivity of (R)-7, respectively.

  7. Hazard degree identification of goafs based on scale effect of structure by RS-TOPSIS method

    Institute of Scientific and Technical Information of China (English)

    胡建华; 甯榆林; 尚俊龙; 刘浪; 周科平; 陈宜楷

    2015-01-01

    In order to precisely predict the hazard degree of goaf (HDG), the RS-TOPSIS model was built based on the results of expert investigation. To evaluate the HDG in the underground mine, five structure size factors, i.e. goaf span, exposed area, goaf height, goaf depth, and pillar width, were selected as the evaluation indexes. And based on rough dependability in rough set (RS) theory, the weights of evaluation indexes were identified by calculating rough dependability between evaluation indexes and evaluation results. Fourty goafs in some mines of western China, whose indexes parameters were measured by cavity monitoring system (CMS), were taken as evaluation objects. In addition, the characteristic parameters of five grades’ typical goafs were built according to the interval limits value of single index evaluation. Then, using the technique for order preference by similarity to ideal solution (TOPSIS), five-category classification of HDG was realized based on closeness degree, and the HDG was also identified. Results show that the five-category identification of mine goafs could be realized by RS-TOPSIS method, based on the structure-scale-effect. The classification results are consistent with those of numerical simulation based on stress and displacement, while the coincidence rate is up to 92.5%. Furthermore, the results are more conservative to safety evaluation than numerical simulation, thus demonstrating that the proposed method is more easier, reasonable and more definite for HDG identification.

  8. ANIMAL WELFARE FROM MOUSE TO MOOSE--IMPLEMENTING THE PRINCIPLES OF THE 3RS IN WILDLIFE RESEARCH.

    Science.gov (United States)

    Lindsjö, Johan; Fahlman, Åsa; Törnqvist, Elin

    2016-04-01

    The concept of the 3Rs (replacement, reduction, and refinement) was originally developed for improving laboratory animal welfare and is well known in biomedical and toxicologic research. The 3Rs have so far gained little attention in wildlife research, and there could be several reasons for this. First, researchers may prioritize the welfare of populations and ecosystems over the welfare of individual animals. The effects of research on individual animals can, however, impact welfare and research quality at group and population levels. Second, researchers may find it difficult to apply the 3Rs to studies of free-living wildlife because of the differences between laboratory and wild animals, species, research environment, and purpose and design of the studies. There are, however, several areas where it is possible to transfer the 3R principles to wildlife research, including replacement with noninvasive research techniques, reduction with optimized experimental design, and refinement with better methods of capture, anesthesia, and handling. Third, researchers may not have been trained in applying the 3Rs in wildlife research. This training is needed since ethics committees, employers, journal publishers, and funding agencies increasingly require researchers to consider the welfare implications of their research. In this paper, we compare the principles of the 3Rs in various research areas to better understand the possibilities and challenges of the 3Rs in wildlife research. We emphasize the importance of applying the 3Rs systematically throughout the research process. Based on experiences from laboratory research, we suggest three key factors to enhance implementation of the 3Rs in wildlife research: 1) organizational structure and management, 2) 3R awareness, and 3) research innovation, validation, and implementation. Finally, we encourage an interdisciplinary approach to incorporate the 3R principles in wildlife research. For improved animal welfare and increased

  9. Polymorphism rs11085226 in the gene encoding polypyrimidine tract-binding protein 1 negatively affects glucose-stimulated insulin secretion.

    Directory of Open Access Journals (Sweden)

    Martin Heni

    Full Text Available OBJECTIVE: Polypyrimidine tract-binding protein 1 (PTBP1 promotes stability and translation of mRNAs coding for insulin secretion granule proteins and thereby plays a role in β-cells function. We studied whether common genetic variations within the PTBP1 locus influence insulin secretion, and/or proinsulin conversion. METHODS: We genotyped 1,502 healthy German subjects for four tagging single nucleotide polymorphisms (SNPs within the PTBP1 locus (rs351974, rs11085226, rs736926, and rs123698 covering 100% of genetic variation with an r(2≥0.8. The subjects were metabolically characterized by an oral glucose tolerance test with insulin, proinsulin, and C-peptide measurements. A subgroup of 320 subjects also underwent an IVGTT. RESULTS: PTBP1 SNP rs11085226 was nominally associated with lower insulinogenic index and lower cleared insulin response in the OGTT (p≤0.04. The other tested SNPs did not show any association with the analyzed OGTT-derived secretion parameters. In the IVGTT subgroup, SNP rs11085226 was accordingly associated with lower insulin levels within the first ten minutes following glucose injection (p = 0.0103. Furthermore, SNP rs351974 was associated with insulin levels in the IVGTT (p = 0.0108. Upon interrogation of MAGIC HOMA-B data, our rs11085226 result was replicated (MAGIC p = 0.018, but the rs351974 was not. CONCLUSIONS: We conclude that common genetic variation in PTBP1 influences glucose-stimulated insulin secretion. This underlines the importance of PTBP1 for beta cell function in vivo.

  10. ANIMAL WELFARE FROM MOUSE TO MOOSE--IMPLEMENTING THE PRINCIPLES OF THE 3RS IN WILDLIFE RESEARCH.

    Science.gov (United States)

    Lindsjö, Johan; Fahlman, Åsa; Törnqvist, Elin

    2016-04-01

    The concept of the 3Rs (replacement, reduction, and refinement) was originally developed for improving laboratory animal welfare and is well known in biomedical and toxicologic research. The 3Rs have so far gained little attention in wildlife research, and there could be several reasons for this. First, researchers may prioritize the welfare of populations and ecosystems over the welfare of individual animals. The effects of research on individual animals can, however, impact welfare and research quality at group and population levels. Second, researchers may find it difficult to apply the 3Rs to studies of free-living wildlife because of the differences between laboratory and wild animals, species, research environment, and purpose and design of the studies. There are, however, several areas where it is possible to transfer the 3R principles to wildlife research, including replacement with noninvasive research techniques, reduction with optimized experimental design, and refinement with better methods of capture, anesthesia, and handling. Third, researchers may not have been trained in applying the 3Rs in wildlife research. This training is needed since ethics committees, employers, journal publishers, and funding agencies increasingly require researchers to consider the welfare implications of their research. In this paper, we compare the principles of the 3Rs in various research areas to better understand the possibilities and challenges of the 3Rs in wildlife research. We emphasize the importance of applying the 3Rs systematically throughout the research process. Based on experiences from laboratory research, we suggest three key factors to enhance implementation of the 3Rs in wildlife research: 1) organizational structure and management, 2) 3R awareness, and 3) research innovation, validation, and implementation. Finally, we encourage an interdisciplinary approach to incorporate the 3R principles in wildlife research. For improved animal welfare and increased

  11. The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

    DEFF Research Database (Denmark)

    Campa, Daniele; Hüsing, Anika; McKay, James D.;

    2010-01-01

    Background The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body...... fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures...

  12. Controle da qualidade das sementes de arroz irrigado utilizadas em Santa Maria/RS Control of quality of the flooded rice seeds in Santa Maria/RS

    OpenAIRE

    Enio Marchezan; Nilson Lemos de Menezes; Carla do Amaral Siqueira

    2001-01-01

    Este trabalho foi desenvolvido com o objetivo de caracterizar e classificar a qualidade física, fisiológica e sanitária das sementes de arroz irrigado utilizadas por produtores de Santa Maria/RS, Brasil. Foram coletadas 117 amostras de sementes de produtores da região, no ano agrícola de 1997/98, nas quais se determinaram umidade, presença de grãos de arroz vermelho, presença de fungos e nematóides, germinação e vigor. As sementes apresentaram qualidade fisiológica e sanitária de média a boa,...

  13. Colesterolemia, trigliceridemia e excesso de peso em escolares de Santa Maria, RS, Brasil Blood lipids abnormalities and overweight prevalence in students of Santa Maria, RS, Brazil

    Directory of Open Access Journals (Sweden)

    Cláudia Cruz Lunardi

    2010-08-01

    Full Text Available INTRODUÇÃO: O nível de colesterol na infância é um preditor do nível de colesterol na vida adulta. As consequências do colesterol elevado, somadas a outros fatores de risco constituem problema mundial de saúde pública. OBJETIVO: Estimar a prevalência de hipercolesterolemia, hipertrigliceridemia e excesso de peso em estudantes do município de Santa Maria-RS. Métodos: Estudo transversal com 374 crianças de 10 a 12 anos de idade, de escolas das redes pública e privada, realizado no segundo semestre de 2005 na cidade de Santa Maria-RS. Foram determinados os níveis de colesterol total, triglicerídeos e estado nutricional. RESULTADOS: As prevalências de hipercolesterolemia, hipertrigliceridemia e excesso de peso encontradas foram de 4,7%, 8,9% e 20,7%, respectivamente. Não houve diferença significante entre sexo e rede pública e privada. As crianças com excesso de peso apresentaram maior prevalência de alterações lipídicas. CONCLUSÕES: A prevalência de alterações lipídicas pode ser considerada baixa, mas a prevalência de excesso de peso dos estudantes de Santa Maria mostrou-se relativamente alta, alertando à importância de políticas públicas e à necessidade de assistência pediátrica nessa faixa etária, visando o seu diagnóstico precoce e, principalmente, o aconselhamento nutricional e incentivo à prática esportiva, uma vez que as dislipidemias e o excesso de peso têm sido apontados como fatores de risco para as doenças cardiovasculares.INTRODUCTION: Cholesterol level in childhood is a predictor of cholesterol level in adult life. The consequences of high cholesterol levels summed to other risk factors constitute a worldwide public health problem. OBJECTIVE: To estimate the prevalence of blood lipid abnormalities and overweight among school students of the city of Santa Maria, RS, Brazil. Methods: A cross-sectional study with 374 children, aged between 10 and 12 years, from public and private schools of the

  14. A Design of SSI-RS485 Converter%一种SSI转RS485转换器的设计

    Institute of Scientific and Technical Information of China (English)

    张博; 曹世康

    2010-01-01

    设计了一种基于单片机ATtiny2313的协议转换器. 转换器的主要任务是将系统中多圈绝对式旋转编码器SSI(同步串行接口)协议转换为车载控制器的RS485协议. 针对复杂的车载系统,给出了若干转换器的抗干扰措施. 实践证明:所设计的转换器结构简单、运行可靠、抗干扰能力强,能实现SSI接口的传输速度快、连线简单、抗干扰能力强的优点,便于与车载控制系统的集成.

  15. Preliminary evidence for cue-induced alcohol craving modulated by serotonin transporter gene polymorphism rs1042173

    Directory of Open Access Journals (Sweden)

    Nassima eAit-Daoud

    2012-02-01

    Full Text Available We previously have shown that cue-induced alcohol craving and propensity for higher drinking are modulated by allelic differences in SLC6A4. In an independent study, we characterized a functional polymorphism, rs1042173 (G/T, in the SLC6A4 3′-untranslated region (3′-UTR; the T allele was associated with lower mRNA and protein levels, and the alcohol-dependent (AD individuals carrying the TT genotype showed higher drinking intensity compared with G-allele carriers. Building upon these findings, we hypothesized that the low-expressing TT genotype associated with intense drinking would predict higher craving for alcohol in AD individuals. In this pilot study, we sought to test our hypothesis by examining 34 Hispanic AD volunteers (mean age, 34.8 years for rs1042173 genotype-based (i.e., TT vs. TG/GG (Gx differences in subjective response to alcohol. We employed a human laboratory paradigm and analyzed the data using a linear mixed-effects model to assess treatment, cue procedures, and genotype main effects as well as the two-way interaction effects between them. On subjective urge to drink and crave for a drink, we found a significant main effect of the cue experiment (p ≤ 0.01 and an interaction effect between genotype and cue effects (p < 0.05. TT genotype was associated with higher intensity of drinking and craving for alcohol. Our results not only support the hypothesis that rs1042173 is a genetic marker for cue-induced alcohol craving among AD males but also are suggestive of a neurobiological mechanism associated with the rs1042173-TT genotype that triggers a disproportionate craving in response to alcohol consumption, which in turn may lead to more intense drinking. Future studies with larger sample sizes are needed to characterize the interactive effects of the serotonin transporter-linked polymorphic region (5′-HTTLPR-L-allele reported in our previous study and of the rs1042173-TT genotype on cue-induced alcohol craving.

  16. Reference quality upper-air measurements: GRUAN data processing for the Vaisala RS92 radiosonde

    Directory of Open Access Journals (Sweden)

    R. J. Dirksen

    2014-12-01

    Full Text Available The GCOS (Global Climate Observing System Reference Upper-Air Network (GRUAN data processing for the Vaisala RS92 radiosonde was developed to meet the criteria for reference measurements. These criteria stipulate the collection of metadata, the use of well-documented correction algorithms, and estimates of the measurement uncertainty. An important and novel aspect of the GRUAN processing is that the uncertainty estimates are vertically resolved. This paper describes the algorithms that are applied in version 2 of the GRUAN processing to correct for systematic errors in radiosonde measurements of pressure, temperature, humidity, and wind, as well as how the uncertainties related to these error sources are derived. Currently, the RS92 is launched on a regular basis at 13 out of 15 GRUAN sites. An additional GRUAN requirement for performing reference measurements with the RS92 is that the manufacturer-prescribed procedure for the radiosonde's preparation, i.e. heated reconditioning of the sensors and recalibration during ground check, is followed. In the GRUAN processing however, the recalibration of the humidity sensors that is applied during ground check is removed. For the dominant error source, solar radiation, laboratory experiments were performed to investigate and model its effect on the RS92's temperature and humidity measurements. GRUAN uncertainty estimates are 0.15 K for night-time temperature measurements and approximately 0.6 K at 25 km during daytime. The other uncertainty estimates are up to 6% relative humidity for humidity, 10–50 m for geopotential height, 0.6 hPa for pressure, 0.4–1 m s−1 for wind speed, and 1° for wind direction. Daytime temperature profiles for GRUAN and Vaisala processing are comparable and consistent within the estimated uncertainty. GRUAN daytime humidity profiles are up to 15% moister than Vaisala processed profiles, of which two-thirds is due to the radiation dry bias correction and one-third is due

  17. RS-SNP: a random-set method for genome-wide association studies

    Directory of Open Access Journals (Sweden)

    Mukherjee Sayan

    2011-03-01

    Full Text Available Abstract Background The typical objective of Genome-wide association (GWA studies is to identify single-nucleotide polymorphisms (SNPs and corresponding genes with the strongest evidence of association (the 'most-significant SNPs/genes' approach. Borrowing ideas from micro-array data analysis, we propose a new method, named RS-SNP, for detecting sets of genes enriched in SNPs moderately associated to the phenotype. RS-SNP assesses whether the number of significant SNPs, with p-value P ≤ α, belonging to a given SNP set is statistically significant. The rationale of proposed method is that two kinds of null hypotheses are taken into account simultaneously. In the first null model the genotype and the phenotype are assumed to be independent random variables and the null distribution is the probability of the number of significant SNPs in greater than observed by chance. The second null model assumes the number of significant SNPs in depends on the size of and not on the identity of the SNPs in . Statistical significance is assessed using non-parametric permutation tests. Results We applied RS-SNP to the Crohn's disease (CD data set collected by the Wellcome Trust Case Control Consortium (WTCCC and compared the results with GENGEN, an approach recently proposed in literature. The enrichment analysis using RS-SNP and the set of pathways contained in the MSigDB C2 CP pathway collection highlighted 86 pathways rich in SNPs weakly associated to CD. Of these, 47 were also indicated to be significant by GENGEN. Similar results were obtained using the MSigDB C5 pathway collection. Many of the pathways found to be enriched by RS-SNP have a well-known connection to CD and often with inflammatory diseases. Conclusions The proposed method is a valuable alternative to other techniques for enrichment analysis of SNP sets. It is well founded from a theoretical and statistical perspective. Moreover, the experimental comparison with GENGEN highlights that it is

  18. Association between SERPING1 rs2511989 polymorphism and age-related macular degeneration: Meta-analysis

    Institute of Scientific and Technical Information of China (English)

    Yi; Dong; Ze-Dong; Li; Xin-Yu; Fang; Xue-Feng; Shi; Song; Chen; Xin; Tang

    2015-01-01

    AIM: To investigate the association between SERPING1rs2511989(G>A) polymorphism and age-related macular degeneration(AMD).METHODS: A number of electronic databases(up to July 15, 2014) were searched independently by two investigators. A Meta-analysis was performed on the association between SERPING1 rs2511989 polymorphism and AMD. Pooled odds ratios(ORs) with 95% confidence intervals(CIs) were estimated.RESULTS: Eight studies with 16 cohorts consisting of9163 cases and 6813 controls were included in this Metaanalysis. There was no significant association between rs2511989 polymorphism and AMD under all genetic models in overall estimates(A vs G: OR= 0.938, 95%CI =0.858-1.025; AA vs GG:OR =0.871, 95% CI =0.719-1.056;AG vs GG: OR =0.944, 95% CI =0.845-1.054; AA +AG vs GG: OR =0.927, 95% CI =0.823-1.044; AA vs AG +GG:OR =0.890, 95% CI =0.780-1.034). Cumulative Meta-analyses also showed a trend of no association between rs2511989 polymorphism and AMD as information accumulated by year. Subgroup analysis and Meta-regression analysis indicated that age-matching status was the main source of heterogeneity. Sensitivity analysis found the results in overall comparisons and subgroup comparisons of white subjects under the allele model were found to have significantly statistical differences after studies deviating from Hardy-Weinberg equilibrium(HWE) were excluded(overall: OR=0.918, 95%CI = 0.844-0.999, P =0.049; whites: OR =0.901, 95% CI =0.817-0.994, P =0.038). However, the results were notsufficiently robust for further sensitivity analysis and statistical differences disappeared on applying Bonferroni correction(with a significance level set at 0.05/25).CONCLUSION: This Meta-analysis indicates that SERPING1 rs2511989 polymorphism and AMD tend to have no association with each other. Age matching status is a big confounding factor, and more studies with subtle designs are warranted in future.

  19. Controle da qualidade das sementes de arroz irrigado utilizadas em Santa Maria/RS Control of quality of the flooded rice seeds in Santa Maria/RS

    Directory of Open Access Journals (Sweden)

    Enio Marchezan

    2001-06-01

    Full Text Available Este trabalho foi desenvolvido com o objetivo de caracterizar e classificar a qualidade física, fisiológica e sanitária das sementes de arroz irrigado utilizadas por produtores de Santa Maria/RS, Brasil. Foram coletadas 117 amostras de sementes de produtores da região, no ano agrícola de 1997/98, nas quais se determinaram umidade, presença de grãos de arroz vermelho, presença de fungos e nematóides, germinação e vigor. As sementes apresentaram qualidade fisiológica e sanitária de média a boa, contendo, no entanto, altos níveis de arroz vermelho, o que reduz a qualidade dos lotes e constitui-se no principal fator restritivo à obtenção de maiores rendimentos.This study was conducted in order to characterize and classify the physical, physiological and sanitary qualities of irrigated rice seeds used by rice farmers in Santa Maria (RS. A total of 117 seed samples were collected among farmers of this region during the 1997/98 growing season. Seed moisture, presense of red rice seeds, presense of fungy and nematodes, germination percentage and seed vigor were determined. In regard to physyological and sanitary quality the seed qualities varied between medium and good. However the presense of high levels of red rice seeds reduced the overall quality of the seeds and is the main factor that limits higher productivity grains.

  20. Application of RS485 Protocol in Horizontal Impregnating and Drying Production Line%基于RS485协议的通信技术在卧式浸渍干燥生产线中的应用

    Institute of Scientific and Technical Information of China (English)

    薛建利; 宋惠萌

    2014-01-01

    基于底层RS485协议的通信方式以其良好的性价比、极强的通用性在工业现场被广泛采用。本文主要介绍了通过RS485协议的汇川PLC、伺服控制系统在人造板二次加工卧式浸渍干燥生产线中的应用。%With attractive price/quality ratio and the high versatility, the underlying communication mode based on RS485 protocol is widely used in the fieldwork. This paper mainly described the application of the Inovance PLC and servo control system with RS485 protocol in the horizontal impregnating and drying production line.

  1. Genome-wide association study identified PLCE1- rs2797992 and EGFR- rs6950826 were associated with TP53 expression in the HBV-related hepatocellular carcinoma of Chinese patients in Guangxi

    Science.gov (United States)

    Liao, Xiwen; Han, Chuangye; Qin, Wei; Liu, Xiaoguang; Yu, Long; Lu, Sicong; Chen, Zhiwei; Zhu, Guangzhi; Su, Hao; Mo, Zengnan; Qin, Xue; Peng, Tao

    2016-01-01

    Objective: The genome-wide association approach was employed to explore the association between single nucleotide polymorphisms (SNPs) and TP53 expression in the HBV-related hepatocellular carcinoma (HCC) of Chinese patients in Guangxi. Methods: 403 HBV-related HCC patients were recruited into this study and classified according to the TP53 expression in the cancer by immunohistochemistry. DNA was extracted from the cancer and genotyped with the Human ExomeBeadChip 12v1-1 system; quality control and principal-component analysis (PCA) were applied for data analysis. Results: The Genome-wide association analysis indicated that rs2797992 with a P value of 4.35 × 10-5 locus in PLCE1 gene and rs6950826 with a P value of 2.2 × 10-3 locus in EGFR gene were associated with TP53 expression in the HCC. A allele of rs2797992 predicted a decreased risk for TP53 expression in HCC. In contrast, A allele of rs6950826 increased the risk for TP53 expression. There was no strong LD locus in the tested regions. PLCE1 and EGFR were associated with TP53 in pathway and at HCC mRNA level. Conclusion: rs2797992 of PLCE1 gene and rs6950826 of EGFR gene are associated with TP53 expression, but not with the prognosis of HBV-related HCC in HBV-related HCC of Chinese patients in Guangxi. PMID:27186304

  2. MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C

    Science.gov (United States)

    Thabet, Khaled; Asimakopoulos, Anastasia; Shojaei, Maryam; Romero-Gomez, Manuel; Mangia, Alessandra; Irving, William L.; Berg, Thomas; Dore, Gregory J.; Grønbæk, Henning; Sheridan, David; Abate, Maria Lorena; Bugianesi, Elisabetta; Weltman, Martin; Mollison, Lindsay; Cheng, Wendy; Riordan, Stephen; Fischer, Janett; Spengler, Ulrich; Nattermann, Jacob; Wahid, Ahmed; Rojas, Angela; White, Rose; Douglas, Mark W.; McLeod, Duncan; Powell, Elizabeth; Liddle, Christopher; van der Poorten, David; George, Jacob; Eslam, Mohammed; Gallego-Duran, Rocio; Applegate, Tanya; Bassendine, Margaret; Rosso, Chiara; Mezzabotta, Lavinia; Leung, Reynold; Malik, Barbara; Matthews, Gail; Grebely, Jason; Fragomeli, Vincenzo; Jonsson, Julie R.; Santaro, Rosanna

    2016-01-01

    Cirrhosis likely shares common pathophysiological pathways despite arising from a variety of liver diseases. A recent GWAS identified rs641738, a polymorphism in the MBOAT7 locus, as being associated with the development of alcoholic cirrhosis. Here we explore the role of this variant on liver inflammation and fibrosis in two cohorts of patients with chronic hepatitis C. In 2,051 patients, rs641738 associated with severe hepatic inflammation and increased risk of fibrosis, as well as fast fibrosis progression. At functional level, rs641738 associated with MBOAT7 transcript and protein levels in liver and blood, and with serum inflammatory, oxidative stress and macrophage activation markers. MBOAT7 was expressed in immune cell subsets, implying a role in hepatic inflammation. We conclude that the MBOAT7 rs641738 polymorphism is a novel risk variant for liver inflammation in hepatitis C, and thereby for liver fibrosis. PMID:27630043

  3. IFN-alpha-3 (IL28B genotyping by restriction fragment length polymorphism method: detection polymorphism of rs12979860

    Directory of Open Access Journals (Sweden)

    Livshits L. A.

    2011-04-01

    Full Text Available Aim. The goal of our study was to develop an accurate detection of the SNP rs12979860 by RFLP-based method and to evaluate the polymorphic genotype distribution for this SNP among individuals with unknown HCV status from Ukraine. Methods.The SNP rs12979860 was tested by PCR RFLP-based method in 99 individuals from Ukraine. Results. The method of accurate detection of the SNP rs12979860 was developed. The genotypes distributions were: CC – 56 %, CT – 34 %, TT – 10 %. Conclusions. Due to the high incidence of CC genotype, found in our study, the SNP rs12979860 analysis may be useful for Ukrainian patients to predict responses to the treatment considering the HCV genotype and viral load.

  4. Trails, RS2477, cinter pit ev, Published in 2004, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2004. It is described as 'cinter pit...

  5. Trails, RS2477, sb events, Published in 2003, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2003. It is described as 'sb events'....

  6. Trails, RS2477, cinter pit rd, Published in 2005, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2005. It is described as 'cinter pit...

  7. Trails, RS2477, add events rev, Published in 2004, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2004. It is described as 'add events...

  8. Trails, RS2477, 3200 ev, Published in 2005, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2005. It is described as '3200 ev'....

  9. Trails, RS2477, add roads, Published in 2003, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2003. It is described as 'add roads'....

  10. Trails, RS2477, 422004 rd NAD83, Published in 2004, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2004. It is described as '422004 rd...

  11. Trails, RS2477, iron sgid, Published in 2003, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2003. It is described as 'iron sgid'....

  12. Trails, RS2477, Juab claims m, Published in 2007, 1:24000 (1in=2000ft) scale, Juab County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2007. It is described as 'Juab claims...

  13. Trails, RS2477, d roads 053008, Published in 2008, 1:24000 (1in=2000ft) scale, Tooele County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2008. It is described as 'd roads...

  14. Trails, RS2477, Juab claims f, Published in 2007, 1:24000 (1in=2000ft) scale, Juab County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2007. It is described as 'Juab claims...

  15. Trails, RS2477, iron rds, Published in 2004, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2004. It is described as 'iron rds'....

  16. Trails, RS2477, 3200 rd, Published in 2005, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2005. It is described as '3200 rd'....

  17. Trails, RS2477, iron events 2, Published in 2003, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2003. It is described as 'iron events...

  18. Trails, RS2477, class b roads, Published in 2006, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2006. It is described as 'class b...

  19. Trails, RS2477, class B, Published in 2005, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2005. It is described as 'class B'....

  20. Trails, RS2477, add roads rev, Published in 2004, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2004. It is described as 'add roads...