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Sample records for 2003-2006 geres iv

  1. SWOV programme 2003-2006.

    2012-01-01

    SWOV uses a four-year programme to structure its activities over a longer period of time. The current four-year programme, for 2003-2006, includes proposals for so-called planning office activities, anticipatory research, knowledge management, and knowledge dissemination. The research activities are

  2. Arboviruses in North Dakota, 2003-2006.

    Anderson, John F; Main, Andy J; Armstrong, Philip M; Andreadis, Theodore G; Ferrandino, Francis J

    2015-02-01

    To investigate arbovirus transmission in North Dakota, we collected and screened mosquitoes for viral infection by Vero cell culture assay. Seven viruses were isolated from 13 mosquito species. Spatial and temporal distributions of the important vectors of West Nile virus (WNV), Cache Valley virus, Jamestown Canyon virus (JCV), and trivittatus virus are reported. Snowshoe hare virus, Potosi virus, and western equine encephalomyelitis virus were also isolated. The risks of Culex tarsalis and Aedes vexans transmitting WNV to humans were 61.4% and 34.0% in 2003-2006, respectively, but in 2003 when the largest epidemic was reported, risks for Ae. vexans and Cx. tarsalis in Cass County were 73.6% and 23.9%, respectively. Risk of humans acquiring an infectious bite was greatest from about the second week of July through most of August. West Nile virus sequences were of the WN02 genotype. Most JCV strains belonged to a single clade of genetically related strains. Cache Valley virus and JCV were prevalent during August and early September and during July and August, respectively.

  3. Zoonoses and zoonotic agents in humans, food, animals and feed in the Netherlands 2003-2006

    Valkenburgh S; Oosterom R van; Stenvers O; Aalten M; Braks M; Schimmer B; Giessen A van de; Pelt W van; Langelaar M; Voedsel en Waren Autoriteit VWS; LZO; EPI

    2007-01-01

    The report 'Zoonoses and Zoonotic Agents in Humans, Food, Animals and Feed in The Netherlands 2003 - 2006' is based on data that is reported annually to the European Commission, in accordance with the Directive 2003/99/EC on the monitoring of zoonoses and zoonotic agents. They are supplemented with

  4. Blended Learning für gering qualifizierte Lerner?

    Anke Grotlüschen

    2006-05-01

    Full Text Available Die seit langem bekannte «Bildungsschere» weitet sich zu einer digitalen Diskriminierung aus: Einkommen und Vorbildung entscheiden darüber, wer an Blended Learning teilnehmen kann. Einige empirische Untersuchungen (v. a. das Berichtssystem Weiterbildung und die sog. München-Studie zeigen auf, wer selbst gesteuert mit Medien lernt. Kontrastierend werden Evaluationsergebnisse eines Förderprojekts vorgestellt. Sie zeigen die Reichweite und Grenzen von E-Learning-Anteilen in Lernszenarien für gering qualifizierte Lernende auf.

  5. Fatalities among oil and gas extraction workers--United States, 2003-2006.

    2008-04-25

    Oil and gas extraction (i.e., removing oil and natural gas from the ground) is a growing industry in the United States, employing approximately 380,000 workers in 2006. In recent years, activity in this industry has increased substantially, from an average of 800 actively drilling rigs in the United States during the 1990s to approximately 1,300 during 2003-2006. In August 2005, the U.S. Department of Labor's Bureau of Labor Statistics (BLS) asked CDC to investigate a 15% increase in fatalities among oil and gas extraction workers (from 85 fatalities in 2003 to 98 in 2004). CDC analyzed data from the BLS Census of Fatal Occupational Injuries (CFOI) for the period 2003-2006. This report describes the results of that analysis, which indicated that increases in oil and gas extraction activity were correlated with an increase in the rate of fatal occupational injuries in this industry, with an annual fatality rate of 30.5 per 100,000 workers (404 fatalities) during 2003-2006, approximately seven times the rate for all workers (4.0 per 100,000 workers). Nearly half of all fatal injuries among these workers were attributed to highway motor-vehicle crashes and workers being struck by machinery or equipment. Employers should work with existing industry groups and federal, state, and local government agencies to promote seatbelt use. In addition, researchers and public health officials should collaborate with industry groups to establish engineering and process controls that remove workers from potentially dangerous machinery while drilling and servicing oil and gas wells.

  6. Perfluoroalkyl substances and endometriosis in US women in NHANES 2003-2006.

    Campbell, Stephanie; Raza, Masooma; Pollack, Anna Z

    2016-10-01

    Exposure to endocrine-active perfluoroalkyl substances (PFASs), is nearly ubiquitous, but data on the association between PFASs and endometriosis diagnosis are limited. We aimed to examine the relationship between PFASs and endometriosis. Women aged 20-50 years from the National Health and Nutrition Examination Survey (2003-2006) were selected (n=753). Serum PFAS levels were measured and endometriosis status was determined by self-report of doctor diagnosis. Weighted survey sampling logistic regression was used. Women reporting endometriosis were older (39.4 vs. 33.7 years), and more likely to be non-Hispanic white. Geometric mean levels of perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), and perfluorooctane sulfonate (PFOS) were significantly higher among women reporting endometriosis. Endometriosis was associated with select quartiles of PFOA, PFNA, and PFOS. Sensitivity analyses had similar results but wider confidence intervals. These findings suggest that PFOA, PFNA, and PFOS may be of interest in future studies with improved endometriosis diagnostic criteria and prospectively measured exposure.

  7. Changes in West Nile virus seroprevalence and antibody titers among Wisconsin mesopredators 2003-2006.

    Docherty, Douglas E; Samuel, Michael D; Egstad, Kristina F; Griffin, Kathryn M; Nolden, Cherrie A; Karwal, Lovkesh; Ip, Hon S

    2009-07-01

    After the 2001 occurrence of West Nile virus (WNV) in Wisconsin (WI), we collected sera, during 2003-2006, from south-central WI mesopredators. We tested these sera to determine WNV antibody prevalence and geometric mean antibody titer (GMAT). Four-fold higher antibody prevalence and 2-fold higher GMAT in 2003-2004 indicated greater exposure of mesopredators to WNV during the apparent epizootic phase. The period 2005-2006 was likely the enzootic phase because WNV antibody prevalence fell to a level similar to other flaviviruses. Our results suggest that, in mesopredators, vector-borne transmission is the primary route of infection and WNV antibodies persist for < 1 year. Mesopredators may be sensitive indicators of West Nile virus spill-over into humans and horses. Mesopredator sero-surveys may complement dead crow surveillance by providing additional data for the timing of public health interventions. Research is needed to clarify the dynamics of WNV infection in these mammals and their role as potential WNV amplifiers.

  8. Assessing Physical Activity and its Relationship to Cardiovascular Risk Factors: NHANES 2003-2006

    Cao Guichan

    2011-05-01

    Full Text Available Abstract Background Levels of physical activity (PA in the general population are difficult to characterize. Historically measurement has been based on self-report, which can be subject to bias. PA monitor use has created opportunities to improve surveillance and analytic research on activity and health. The aims of the current study were to investigate the associations between objectively measured PA and cardiovascular disease risk factors and obesity. Methods Data on PA from accelerometers, demographics, blood pressure, plasma glucose and lipids, self-reported hypertension and diabetes were obtained for adults, ages 20-65, in the NHANES surveys, 2003-2006. Outcomes were assessed as levels of moderate and vigorous activity, percentage of participants meeting recommended guidelines, and the correlations between activity and cardiovascular risk factors. Accelerometry data were available on 3,370 adults. Based on standard algorithms, activity levels were extremely low in all age-gender-race/ethnic groups, with an average of only 1 bout of vigorous activity lasting longer than 1 minute/day. Results Men spent 35 minutes in moderate activity/day, women 21 minutes; >75% of this activity was accumulated in 1-minute bouts. Levels of activity declined sharply after age 50 in all groups. Negative associations were observed between minutes of combined moderate and vigorous activity and systolic blood pressure, blood glucose, diabetes, hypertension, body mass index and obesity, and a positive association was seen with HDL-cholesterol (all P ≤ 0.03, suggesting valid rank ordering of participants by activity level. Conclusion The magnitude of the gap between self-report and accelerometry activity must be a result of either a vast social acceptability bias in reporting or inaccurate measurement with accelerometry. Therefore, due to the low validity of self reported PA data for epidemiologic research, it is pertinent to encourage the use of valid, objective

  9. Bloodstream infections among patients treated with intravenous epoprostenol or intravenous treprostinil for pulmonary arterial hypertension--seven sites, United States, 2003-2006.

    2007-03-02

    Pulmonary arterial hypertension (PAH) is a life-threatening disorder characterized by elevated pulmonary artery pressure and pulmonary vascular resistance. Continuous infusion of a prostanoid, which acts as a vasodilator and anti-proliferative agent, is indicated in the treatment of patients with severe PAH. Two prostanoids are approved for intravenous (IV) use in the United States: epoprostenol (epoprostenol sodium [brand name Flolan], Gilead, Foster City, California) and treprostinil (treprostinil sodium [brand name Remodulin], United Therapeutics, Silver Spring, Maryland). These drugs are administered to PAH patients at hundreds of treatment centers in the United States. In September 2006, CDC received a report from a PAH specialist of a suspected increase in the number of gram-negative bloodstream infections (BSIs) among PAH patients treated with IV treprostinil. CDC conducted a retrospective investigation with the assistance of several state health departments and the cooperation of seven PAH treatment centers to determine the relative rates of BSI in a sample of patients treated with IV treprostinil and IV epoprostenol during 2003--2006. This report describes the results of that investigation, which indicated that, based on combined data from seven separate PAH treatment centers, pooled mean rates of BSI (primarily gram-negative BSI) were significantly higher for patients on treprostinil than for those on epoprostenol. The results do not suggest intrinsic contamination of IV treprostinil as a cause of the infections; the difference in rates might have been caused by differences in preparation and storage of the two agents, differences in catheter care practices, or differences in the anti-inflammatory activity of the agents. Health-care providers who care for PAH patients should be aware of these findings. Further investigation is needed to determine the causes of the different infection rates at centers where this was observed and to determine whether such a

  10. Environmental Assessment of the Gering-Stegall 115-kV Transmission Line Consolidation Project, Scotts Bluff County, Nebraska

    NONE

    1995-05-01

    The Department of Energy (DOE), Western Area Power Administration (Western) proposes to consolidate segments of two transmission lines near the Gering Substation in Gering, Nebraska. The transmission lines are both located in Scotts Bluff County, Nebraska. The transmission lines are both located in Scotts Bluff County, Nebraska, within the city of Gering. Presently, there are three parallel 115-kilovolt (kV) transmission lines on separate rights-of-way (ROW) that terminate at the Gering Substation. The project would include dismantling the Archer-Gering wood-pole transmission line and rebuilding the remaining two lines on single-pole steel double circuit structures. The project would consolidate the Gering-Stegall North and Gering-Stegall South 115-kV transmission lines on to one ROW for a 1.33-mile segment between the Gering Substation and a point west of the Gering Landfill. All existing wood-pole H-frame structures would be removed, and the Gering-Stegall North and South ROWs abandoned. Western is responsible for the design, construction, operation, and maintenance of the line. Western prepared an environmental assessment (EA) that analyzed the potential environmental impacts of the proposed construction, operation, and maintenance of the 115-kV transmission line consolidation. Based on the analyses in the EA, the DOE finds that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act of 1969 (NEPA).

  11. Assessment of financial flow in the health system of Serbia in a period 2003-2006

    Gajić-Stevanović Milena

    2010-01-01

    low as the consequence of relatively low level of GDP in Serbia. Conclusion. Establishing NHA provided a pattern of national healtcare spending and allowed a comparison of healthcare system in Serbia with the systems of other countries. Analysing a period 2003- 2006 revealed a similarity between Serbia and the countries of the European Unity in regard to the level of average financial resources allocation for healthcare expressed as a percentage of GDP, as well as in regard to financiers in the system of healthcare. A high purchasing power disparity, however, in healthcare services was observed between the population of Serbia and other European countries.

  12. Mountain Lions of the Flagstaff Uplands: 2003-2006 Progress Report

    Mattson, David J.

    2007-01-01

    Executive Summary Stakeholders in management of mountain lions in the Flagstaff Uplands of northern Arizona have expressed increasing concern about both potential impacts of humans on lions and potential risks posed by lions to humans. A series of human-mountain lion encounters during 2000-2001 on Mt. Elden, immediately adjacent to Flagstaff, and similar incidents during 2004 near Tucson brought increased attention to management of human safety in mountain lion range. These human-centered concerns, together with long-standing questions about how the human infrastructure centered on Flagstaff might be affecting lion movements led us to initiate a mountain lion study in 2003 which we plan to continue through 2009. Our study focuses on movements and other behaviors of mountain lions, with the goal of providing information that can be used to increase human safety, decrease human impacts, and, overall, provide insight into the ecology of lions in this region. To serve this goal, we have focused on collecting data that will be the basis of explanatory models that can provide spatially-explicit predictions of mountain lion activity, specify the effects of human facilities, such as highways and urban areas, and provide insight into when, where, and how often different kinds of lions kill different kinds of prey. During 2003-2006, we captured six female and five male mountain lions in the Flagstaff Uplands, 10 of which we fitted with collars that collected up to six high-precision GPS fixes per day, transmitted daily to our offices via Argos satellites. This timely delivery of data allowed us to visit kill sites and other foci of localized activity to collect detailed information on lion behavior. By June 2006 we had obtained 9357 GPS locations and visited 394 sites, at which we documented 218 kills, 165 of which were by five females and 53 by five males. These data were the basis for preliminary analyses presented in this report. All lions during all seasons exhibited a

  13. Diet quality is positively associated with 100% fruit juice consumption in children and adults in the United States: NHANES 2003-2006

    One hundred percent fruit juice (100% FJ) has been viewed by some as a sweetened beverage with concerns about its effect on weight. Little regard has been given to the contribution of 100% FJ to diet quality. In this study data from the 2003-2006 National Health and Nutrition Examination Survey were...

  14. Selected physiologic variables are weakly to moderately associated with 29 biomarkers of diet and nutrition, NHANES 2003-2006.

    Haynes, Bridgette M H; Pfeiffer, Christine M; Sternberg, Maya R; Schleicher, Rosemary L

    2013-06-01

    The physiologic status of an individual may influence biomarkers of nutritional status. To help researchers with planning studies and interpreting data, we assessed the associations between common physiologic variables (fasting, inflammation, renal function, and pregnancy) and 29 biomarkers of diet and nutrition measured in blood or urine in a representative sample of the adult U.S. population (aged ≥ 20 y; pregnancy variable and iron indicators limited to women aged 20-49 y) participating in NHANES 2003-2006. We compared simple linear regression (model 1) with multiple linear regression [model 2, controlling for age, sex, race-ethnicity, smoking, supplement use, and the physiologic factors (and urine creatinine for urine biomarkers)] and report significant findings from model 2. Not being fasted was positively associated with most water-soluble vitamins (WSVs) and related metabolites (RMs). Some WSV, fat-soluble vitamin (FSV) and micronutrient (MN), and phytoestrogen concentrations were lower in the presence of inflammation (C-reactive protein ≥ 5 mg/L), whereas fatty acids and most iron indicators were higher. Most WSVs and RMs were higher when renal function was impaired [estimated glomerular filtration rate function, however, showed several large differences for WSV and RM concentrations. This descriptive analysis of associations between physiologic variables and a large number of nutritional biomarkers showed that controlling for demographic variables, smoking, and supplement use generally did not change the interpretation of bivariate results. The analysis serves as a useful basis for more complex future research.

  15. Short report: Changes in West Nile virus seroprevalence and antibody titers among Wisconsin mesopredators 2003-2006

    Docherty, D.E.; Samuel, M.D.; Egstad, K.F.; Griffin, K.M.; Nolden, C.A.; Karwal, L.; Ip, H.S.

    2009-01-01

    After the 2001 occurrence of West Nile virus (WNV) in Wisconsin (WI), we collected sera, during 2003-2006, from south-central WI mesopredators. We tested these sera to determine WNV antibody prevalence and geometric mean antibody titer (GMAT). Four-fold higher antibody prevalence and 2-fold higher GMAT in 2003-2004 indicated greater exposure of mesopredators to WNV during the apparent epizootic phase. The period 2005-2006 was likely the enzootic phase because WNV antibody prevalence fell to a level similar to other flaviviruses. Our results suggest that, in mesopredators, vector-borne transmission is the primary route of infection and WNV antibodies persist for < 1 year. Mesopredators may be sensitive indicators of West Nile virus spill-over into humans and horses. Mesopredator sero-surveys may complement dead crow surveillance by providing additional data for the timing of public health interventions. Research is needed to clarify the dynamics of WNV infection in these mammals and their role as potential WNV amplifiers. Copyright ?? 2009 by The American Society of Tropical Medicine and Hygiene.

  16. electorales 2003-2006

    Francisco Martínez Martínez

    2008-01-01

    Full Text Available La concepción, organización y desarrollo de elecciones son un aspecto de la vida democrática de los Estados modernos, actualmente son determinantes para el correcto ejercicio del poder y de la autoridad pública, por tanto su afección va más allá del simple ejercicio e instrumento del voto; por tal motivo, la integración de la estructura electoral y, particularmente la del Estado de México, reviste interés desde que, a partir del mismo se sustenta una buena parte de la consolidación de las instituciones que, emanadas de tal ejercicio, concite a las mejores prácticas en la vida cotidiana de los habitantes de su territorio, en tal sentido un adecuado sistema de integración e incorporación de servidores electorales prevendría y mejoraría la relación de distanciamiento entre ciudadano y autoridades electorales y, en sentido más amplio, daría confianza y certidumbre a los resultado obtenidos.

  17. Social disparities in exposures to bisphenol A and polyfluoroalkyl chemicals: a cross-sectional study within NHANES 2003-2006

    Nelson Jessica W

    2012-03-01

    Full Text Available Abstract Background Bisphenol A (BPA and polyfluoroalkyl chemicals (PFCs are suspected endocrine disrupting compounds known to be ubiquitous in people's bodies. Population disparities in exposure to these chemicals have not been fully characterized. Methods We analyzed data from the 2003-2006 National Health and Nutrition Examination Survey. Using multivariable linear regression we examined the association between urinary concentrations of BPA, serum concentrations of four PFCs, and multiple measures of socioeconomic position (SEP: family income, education, occupation, and food security. We also examined associations with race/ethnicity. Results All four PFCs were positively associated with family income, whereas BPA was inversely associated with family income. BPA concentrations were higher in people who reported very low food security and received emergency food assistance than in those who did not. This association was particularly strong in children: 6-11 year-olds whose families received emergency food had BPA levels 54% higher (95% CI, 13 to 112% than children of families who did not. For BPA and PFCs we saw smaller and less consistent associations with education and occupation. Mexican Americans had the lowest concentrations of any racial/ethnic group of both types of chemicals; for PFCs, Mexican Americans not born in the U.S. had much lower levels than those born in the U.S. Conclusions People with lower incomes had higher body burdens of BPA; the reverse was true for PFCs. Family income with adjustment for family size was the strongest predictor of chemical concentrations among the different measures of SEP we studied. Income, education, occupation, and food security appear to capture different aspects of SEP that may be related to exposure to BPA and PFCs and are not necessarily interchangeable as measures of SEP in environmental epidemiology studies. Differences by race/ethnicity were independent of SEP.

  18. Estudo longitudinal sobre qualidade e equidade no ensino fundamental brasileiro: GERES 2005 Estudio longitudinal sobre cualidad y equidad en la enseñanza fundamental brasileña: GERES 2005 Longitudinal study of quality and equity in the Brazilian elementary education: GERES 2005

    Creso Franco

    2008-12-01

    Full Text Available Este artigo apresenta o relato do desenho metodológico do "Estudo longitudinal sobre qualidade e eficácia no ensino fundamental brasileiro: GERES 2005". O GERES ainda está em desenvolvimento e sua principal característica é o acompanhamento de uma mesma amostra de alunos dos anos iniciais do ensino fundamental ao longo de quatro anos. Cinco cidades participam do estudo, a saber: Belo Horizonte (MG, Rio de Janeiro (RJ, Salvador (BA, Campinas (SP e Campo Grande (MS. O estudo começou em 2005 e envolve a aplicação de testes cognitivos em Leitura e em Matemática, bem como questionários contextuais para alunos, professores e diretores das escolas participantes. A Teoria de Resposta ao Item Paramétrica tem sido utilizada com o propósito de equalização das escalas para os diferentes níveis de escolarização (anos ou seus equivalentes, de modo que seja possível obter uma curva de crescimento da proficiência ao longo do tempo para cada aluno observado. O GERES tem como objetivo central investigar quais práticas pedagógicas e condições escolares contribuem para a promoção da eficácia e da eqüidade escolar, tendo como principal abordagem analítica a utilização de modelos multiníveis.Este artículo presenta relato del diseño metodológico del "Estudio longitudinal sobre cualidad y eficacia en la enseñanza fundamental brasileña: GERES 2005". El GERES aún está en desenvolvimiento y su principal característica es el acompañamiento de una misma muestra de alumnos de los años iniciales de la enseñanza fundamental al longo de cuatro años. Cinco ciudades participan del estudio, a saber: Belo Horizonte (MG, Rio de Janeiro (RJ, Salvador (BA, Campinas (SP e Campo Grande (MS. El estudio comenzó en 2005 y envuelve la aplicación de testes cognitivos en Lectura y en Matemática, bien como cuestionarios contextuales para alumnos, profesores y directores de las escuelas participantes. La Teoría de Respuesta al Ítem Param

  19. Population-referenced percentiles for waist-worn accelerometer-derived total activity counts in U.S. youth: 2003 - 2006 NHANES.

    Dana L Wolff-Hughes

    Full Text Available The total activity volume performed is an overall measure that takes into account the frequency, intensity, and duration of activities performed. The importance of considering total activity volume is shown by recent studies indicating that light physical activity (LPA and intermittent moderate-to-vigorous physical activity (MVPA have health benefits. Accelerometer-derived total activity counts (TAC per day from a waist-worn accelerometer can serve as a proxy for an individual's total activity volume. The purpose of this study was to develop age- and gender-specific percentiles for daily TAC, minutes of MVPA, and minutes of LPA in U.S. youth ages 6 - 19 y.Data from the 2003 - 2006 NHANES waist-worn accelerometer component were used in this analysis. The sample was composed of youth aged 6 - 19 years with at least 4 d of ≥ 10 hours of accelerometer wear time (N = 3698. MVPA was defined using age specific cutpoints as the total number of minutes at ≥4 metabolic equivalents (METs for youth 6 - 17 y or minutes with ≥2020 counts for youth 18 - 19 y. LPA was defined as the total number of minutes between 100 counts and the MVPA threshold. TAC/d, MVPA, and LPA were averaged across all valid days.For males in the 50th percentile, the median activity level was 441,431 TAC/d, with 53 min/d of MVPA and 368 min/d of LPA. The median level of activity for females was 234,322 TAC/d, with 32 min/d of MVPA and 355 min/d of LPA.Population referenced TAC/d percentiles for U.S. youth ages 6-19 y provide a novel means of characterizing the total activity volume performed by children and adolescents.

  20. Molecular characterisation of African swine fever viruses from Nigeria (2003-2006) recovers multiple virus variants and reaffirms CVR epidemiological utility.

    Owolodun, Olajide A; Bastos, Armanda D S; Antiabong, John F; Ogedengbe, Mosunmola E; Ekong, Pius S; Yakubu, Bitrus

    2010-12-01

    Samples collected from wild and domestic suids in Nigeria, over a 3-year period (2003-2006), were evaluated for African swine fever (ASF) virus genome presence by targeting three discrete genome regions, namely the 478-bp C-terminal p72 gene region advocated for genotype assignment, a 780-bp region spanning the 5'-ends of the pB125R and pB646L (p72) genes and the hypervariable central variable region (CVR) encoded within the 9RL ORF (pB602L). ASF virus (ASFV) presence was confirmed in 23 of the 26 wild and domestic pigs evaluated. No evidence of ASF infection was found in two warthogs from Adamawa State; however, one bushpig from Plateau State was positive. Nucleotide sequences of the 478-bp and 780-bp amplicons were identical across all ASFV-positive samples sequenced. However, five discrete CVR variants were recovered, bringing the total number identified to date, from Nigeria, to six. The largest of the CVR variants, termed 'Tet-36' was identical to a virus causing outbreaks in neighbouring Benin in 1997, indicating a prolonged persistence of this virus type in Nigeria. Co-circulation of three tetramer types (Tet-36, Tet-27 and Tet-20) was found in Plateau State in July 2004, whilst in Benue State, two tetramer types (Tet-20 and Tet-21) were present in August 2005. Despite simultaneous field presence, individual co-infection was not observed. This study has reaffirmed the epidemiological utility of the CVR genome region for distinguishing between geographically and temporally constrained genotype I viruses, and has revealed the presence of multiple ASFV variants in Nigeria.

  1. Diet quality is positively associated with 100% fruit juice consumption in children and adults in the United States: NHANES 2003-2006

    Zanovec Michael

    2011-02-01

    Full Text Available Abstract Background One hundred percent fruit juice (100% FJ has been viewed by some as a sweetened beverage with concerns about its effect on weight. Little regard has been given to the contribution of 100% FJ to diet quality. Methods In this study data from the 2003-2006 National Health and Nutrition Examination Survey were used to examine the association of 100% FJ consumption with diet quality in participants 2-5 years of age (y (n = 1665, 6-12 y (n = 2446, 13-18 y (n = 3139, and 19+y (n = 8861. Two 24-hour dietary recalls were used to determine usual intake using the National Cancer Institute method. Usual intake, standard errors, and regression analyses (juice independent variable and Healthy Eating Index-2005 [HEI-2005] components were dependent variables, using appropriate covariates, were determined using sample weights. Results The percentage of participants 2-5 y, 6-12 y, 13-18 y, and 19+y that consumed 100% FJ was 71%, 57%, 45%, and 62%, respectively. Usual intake of 100% FJ (ounce [oz]/day among the four age groups was: 5.8 ± 0.6, 2.6 ± 0.4, 3.7 ± 0.4, and 2.4 ± 0.2 for those in age groups 2-5 y, 6-12 y, 13-18 y, and 19+y, respectively. Consumption of 100% FJ was associated with higher energy intake in 6-12 y, 13-18 y, and 19+y; and higher total, saturated, and discretionary fats in 13-18 y participants. Consumption of 100% FJ was associated with higher total HEI-2005 scores in all age groups ( Conclusions Usual intake of 100% FJ consumption exceeded MyPyramid recommendations for children 2-5 y, but was associated with better diet quality in all age groups and should be encouraged in moderation as part of a healthy diet.

  2. A Política Científica e Tecnológica e as Demandas da Inclusão Social no Governo Lula (2003-2006 [Science and Technology Policy and Demands for Social Inclusion in the Lula Administration (2003-2006

    Milena Pavan Serafim

    2011-09-01

    Full Text Available Este artigo parte da percepção de que houve um fortalecimento da questão social, em especial da inclusão social, no Governo Lula. Seu objetivo é analisar em que medida a Política Científica e Tecnológica incorporou modificações e/ou preocupações semelhantes em sua agenda. Para tanto, apresentamos a trajetória dessa política, destacando o período mais recente. Ao analisar documentos oficiais e bibliografias especializadas, constatamos que a criação da Secretaria Nacional de Ciência e Tecnologia para a Inclusão Social deve ser reconhecida como o surgimento de um novo espaço de disputa, ainda que assimétrica e frágil, no qual os atores antes excluídos do processo de conformação da agenda da PCT podem agora tomar parte. --- Science and Technology Policy and Demands for Social Inclusion in the Lula Administration (2003-2006 --- Abstract --- This paper is based on the perception that there has been increasing concern towards social issues in Brazil, particularly that of social inclusion, during the Lula Administration. The main objective of this paper is to analyze to what degree the agenda of science and technology policy has incorporated similar changes or concerns. We therefore explore the trajectory of this policy, in particular the more recent period. Based on the study of official documents and specialized references, we note that the creation of the National Secretary of Science and Technology for Social Inclusion should be recognized as the emergence of a new field for political struggle, albeit still asymmetrical and frail, in which previously excluded actors may now take part in the agenda setting.

  3. Human brucellosis:seroepidemiology of Tangshan City from 2003 to 2006%2003-2006年唐山市人间布鲁杆菌病血清流行病学分析

    范玉山; 刘丹; 张立山; 王建红

    2008-01-01

    Objective To study the human brucellosis infection status and its epidemic feature during 2003-2006.Methods A total of 485 blood samples of serum underwent rose bengal plate test(RBPT)and serum agglutination test(SAT),which include 422 cases having a history of contacting with sheep/goats or cattle,22 suspected eases,and 41 cases having contacted with infected persons.All cases were diagnosed according serology test and epidemiologic survey.Results The positive rates of Serum antibodies(SAT titer)were 8.8%(12/137),12.7%(8/63),13.1%(22/171)and 16.2%(19/114),respectively,during 2003 to 2006 in Tangshan,in an increasing Rend and peaked in the second and the third seasons 77.0%(47/61).The mostly infected population were those who contacted with sheep/goats or cattle,accounting for 98.4%(60/61).Livestock farmers 86.9%(53/61),and veterinarians 8.2%(5/61)were mostly likely to be infected.Assay of serum antibodies is negative in the persons contacting with infected cases.Conclusions The prevalence of human brucellsis had presented a rising tendency in highly dangerous crowd of Tangshan.Contacting with infected livestock(such as sheep/goats or cattle),especially their aborted materials and placenta were mainly transmitted modes of human brucellsis.However,cases of person-to-person transmission has not been discovered in this study.%目的 了解2003-2006年唐山市人间布鲁杆菌感染状况及其流行病学特征.方法 采集有牛羊接触史人群(422例)、疑似病例(22例)和部分与感染者密切接触人员(41例)的血清共485人份,进行虎红平板凝集试验(RBPT)和试管凝集试验(SAT),根据血清学检验和流行病学调查结果进行病例诊断.结果 2003-2006年唐山市布鲁杆菌病抗体阳性检出率分别为8.8%(12/137)、12.7%(8/63)、13.1%(22/171)、16.2%(19/114),呈逐年上升趋势.2、3季度呈现明显的感染发病高峰,占总感染人数的77.0%(47/61).有明确的牛羊接触史人员占总感染人数的98

  4. Usual dietary intake among female breast cancer survivors is not significantly different from women with no cancer history: results of the National Health and Nutrition Examination Survey, 2003-2006.

    Milliron, Brandy-Joe; Vitolins, Mara Z; Tooze, Janet A

    2014-06-01

    Dietary intake is a modifiable behavior that may reduce the risk of recurrence and death among breast cancer survivors. Cancer survivors are encouraged to consume a diet rich in fruit, vegetables, and whole grains and limit red meat, processed meat, and alcohol intake. Using data from the National Health and Nutrition Examination Survey (2003-2006), this study examined whether breast cancer survivors and women with no history of cancer differed in the distribution of usual intake of foods included in the dietary recommendations for preventing cancer and recurrences. Participants completed one or two 24-hour dietary recalls. The food groups included in this analysis were whole fruit; total vegetables; dark green and orange vegetables; whole grains; red meat; processed meat; alcohol; and calories from solid fat, alcohol, and added sugar. The National Cancer Institute Method was used to estimate the distribution of usual intake and to compare breast cancer survivors (n=102) to noncancer respondents (n=2,684). Using age and cancer survivor as covariates, subgroup estimates of usual intake were constructed. No significant group differences were found, except that survivors reported a greater intake of whole grains. More than 90% of both groups did not meet recommendations for fruits, vegetables, and whole grains; 75.4% and 70.2%, respectively, consumed less than the red meat recommendation; and cancer survivors was not significantly different from women with no history of cancer.

  5. Nutrients from dairy foods are difficult to replace in diets of Americans: food pattern modeling and an analyses of the National Health and Nutrition Examination Survey 2003-2006.

    Fulgoni, Victor L; Keast, Debra R; Auestad, Nancy; Quann, Erin E

    2011-10-01

    Because dairy products provide shortfall nutrients (eg, calcium, potassium, and vitamin D) and other important nutrients, this study hypothesized that it would be difficult for Americans to meet nutritional requirements for these nutrients in the absence of dairy product consumption or when recommended nondairy calcium sources are consumed. To test this hypothesis, MyPyramid dietary pattern modeling exercises and an analyses of data from the National Health and Nutrition Examination Survey 2003-2006 were conducted in those aged at least 2 years (n = 16 822). Impact of adding or removing 1 serving of dairy, removing all dairy, and replacing dairy with nondairy calcium sources was evaluated. Dietary pattern modeling indicated that at least 3 servings of dairy foods are needed to help individuals meet recommendations for nutrients, such as calcium and magnesium, and 4 servings may be needed to help some groups meet potassium recommendations. A calcium-equivalent serving of dairy requires 1.1 servings of fortified soy beverage, 0.6 serving of fortified orange juice, 1.2 servings of bony fish, or 2.2 servings of leafy greens. The replacement of dairy with calcium-equivalent foods alters the overall nutritional profile of the diet and affects nutrients including protein, potassium, magnesium, phosphorus, riboflavin, vitamins A, D and B(12). Similar modeling exercises using consumption data from the National Health and Nutrition Examination Survey also demonstrated that nondairy calcium replacement foods are not a nutritionally equivalent substitute for dairy products. In conclusion, although it is possible to meet calcium intake recommendations without consuming dairy foods, calcium replacement foods are not a nutritionally equivalent substitute for dairy foods and consumption of a calcium-equivalent amount of some nondairy foods is unrealistic.

  6. 100% Orange juice consumption is associated with better diet quality, improved nutrient adequacy, decreased risk for obesity, and improved biomarkers of health in adults: National Health and Nutrition Examination Survey, 2003-2006

    O’Neil Carol E

    2012-12-01

    Full Text Available Abstract Background Consumption of 100% orange juice (OJ has been positively associated with nutrient adequacy and diet quality, with no increased risk of overweight/obesity in children; however, no one has examined these factors in adults. The purpose of this study was to examine the association of 100% OJ consumption with nutrient adequacy, diet quality, and risk factors for metabolic syndrome (MetS in a nationally representative sample of adults. Methods Data from adults 19+ years of age (n = 8,861 participating in the National Health and Nutrition Examination Survey 2003-2006 were used. The National Cancer Institute method was used to estimate the usual intake (UI of 100% OJ consumption, selected nutrients, and food groups. Percentages of the population below the Estimated Average Requirement (EAR or above the Adequate Intake (AI were determined. Diet quality was measured by the Healthy Eating Index-2005 (HEI-2005. Covariate adjusted logistic regression was used to determine if consumers had a lower odds ratio of being overweight or obese or having risk factors of MetS or MetS. Results Usual per capita intake of 100% OJ was 50.3 ml/d. Among consumers (n = 2,310; 23.8%, UI was 210.0 ml/d. Compared to non-consumers, consumers had a higher (p  Conclusion The results suggest that moderate consumption of 100% OJ should be encouraged to help individuals meet the USDA daily recommendation for fruit intake and as a component of a healthy diet.

  7. Asteroids IV

    Michel, Patrick; DeMeo, Francesca E.; Bottke, William F.

    . Asteroids, like planets, are driven by a great variety of both dynamical and physical mechanisms. In fact, images sent back by space missions show a collection of small worlds whose characteristics seem designed to overthrow our preconceived notions. Given their wide range of sizes and surface compositions, it is clear that many formed in very different places and at different times within the solar nebula. These characteristics make them an exciting challenge for researchers who crave complex problems. The return of samples from these bodies may ultimately be needed to provide us with solutions. In the book Asteroids IV, the editors and authors have taken major strides in the long journey toward a much deeper understanding of our fascinating planetary ancestors. This book reviews major advances in 43 chapters that have been written and reviewed by a team of more than 200 international authorities in asteroids. It is aimed to be as comprehensive as possible while also remaining accessible to students and researchers who are interested in learning about these small but nonetheless important worlds. We hope this volume will serve as a leading reference on the topic of asteroids for the decade to come. We are deeply indebted to the many authors and referees for their tremendous efforts in helping us create Asteroids IV. We also thank the members of the Asteroids IV scientific organizing committee for helping us shape the structure and content of the book. The conference associated with the book, "Asteroids Comets Meteors 2014" held June 30-July 4, 2014, in Helsinki, Finland, did an outstanding job of demonstrating how much progress we have made in the field over the last decade. We are extremely grateful to our host Karri Muinonnen and his team. The editors are also grateful to the Asteroids IV production staff, namely Renée Dotson and her colleagues at the Lunar and Planetary Institute, for their efforts, their invaluable assistance, and their enthusiasm; they made life as

  8. Toward Phase IV, Populating the WOVOdat Database

    Ratdomopurbo, A.; Newhall, C. G.; Schwandner, F. M.; Selva, J.; Ueda, H.

    2009-12-01

    One of challenges for volcanologists is the fact that more and more people are likely to live on volcanic slopes. Information about volcanic activity during unrest should be accurate and rapidly distributed. As unrest may lead to eruption, evacuation may be necessary to minimize damage and casualties. The decision to evacuate people is usually based on the interpretation of monitoring data. Over the past several decades, monitoring volcanoes has used more and more sophisticated instruments. A huge volume of data is collected in order to understand the state of activity and behaviour of a volcano. WOVOdat, The World Organization of Volcano Observatories (WOVO) Database of Volcanic Unrest, will provide context within which scientists can interpret the state of their own volcano, during and between crises. After a decision during the 2000 IAVCEI General Assembly to create WOVOdat, development has passed through several phases, from Concept Development (Phase-I in 2000-2002), Database Design (Phase-II, 2003-2006) and Pilot Testing (Phase-III in 2007-2008). For WOVOdat to be operational, there are still two (2) steps to complete, which are: Database Population (Phase-IV) and Enhancement and Maintenance (Phase-V). Since January 2009, the WOVOdat project is hosted by Earth Observatory of Singapore for at least a 5-year period. According to the original planning in 2002, this 5-year period will be used for completing the Phase-IV. As the WOVOdat design is not yet tested for all types of data, 2009 is still reserved for building the back-end relational database management system (RDBMS) of WOVOdat and testing it with more complex data. Fine-tuning of the WOVOdat’s RDBMS design is being done with each new upload of observatory data. The next and main phase of WOVOdat development will be data population, managing data transfer from multiple observatory formats to WOVOdat format. Data population will depend on two important things, the availability of SQL database in volcano

  9. Sable Island air monitoring program report: 2003-2006

    Waugh, David; Inkpen, Tracey; Hingston, Michael; Keast, Stephanie; McPherson, Johnny; Worthy, Doug; Forbes, Gerry [Air Quality Sciences, Meteorological Service of Canada, Atlantic Region Environment Canada (Canada)

    2010-06-15

    Sable Island is an island situated in the Atlantic which receives pollutant flows from the Great Lakes and the United States Eastern Seaboard. The Sable Island air monitoring station was set up by the Environmental Studies Research Funds and its partners to monitor the concentration of nitrogen oxides (NOx), sulphur oxides (SO2), hydrogen sulphide (H2S), fine particulate matter (PM2.5) and ozone (O3). This paper presents the results of the first 4 years of operation of the station. It was found that concentrations of PM2.5 and ozone exceeded desirable levels on several occasions while concentrations of NOx, SO2 and H2S recorded were much below maximum acceptable levels. In addition it was found that the episodes of elevated pollutant levels were due to transboundary flows from onshore. The Sable Island air monitoring project showed good results in its first 4 years of operation and the project partners are considering extending the program.

  10. Progress in Predictability Studies in China(2003-2006)

    2007-01-01

    Since the last International Union of Geodesy and Geophysics General Assembly(2003),predictability studies in China have made significant progress.For dynamic forecasts,two novel approaches of conditional nonlinear optimal perturbation and nonlinear local Lyapunov exponents were proposed to cope with the predictability problems of weather and climate,which are superior to the corresponding linear theory.A (ENSO)Was provided based on a theoretical model.To improve the forecast skill of an intermediate coupled ENSO model,a new initialization scheme was developed,and its applicability was illustrated by hindcast experiments.Using the reconstruction phase space theory and the spatio-temporal series predictive method,Chinese scientists also proposed a new approach to improve dynamical extended range(monthly) prediction and successfully applied it to the monthly-scale predictability of short-term climate variations.In statistical forecasts,it Was found that the effects of sea surface temperature on precipitation in China have obvious spatial and temporal distribution features,and that summer precipitation patterns over east China are closely related to the northern atmospheric circulation.For ensemble forecasts,a new initial perturbation method was used to forecast heavy rain in Guangdong and Fujian Provinces on 8 June 1998.Additionally,the ensemble forecast approach was also used for the prediction of a tropical typhoons.A new dowuscaling model consisting of dynamical and statistical methods was provided to improve the prediction of the monthly mean precipitation.This new downscaling model showed a relatively higher score than the issued operational forecast.

  11. A política africana do governo Lula: (2003-2006 The Lula government's African policy: (2003-2006

    Cláudio Oliveira Ribeiro

    2009-01-01

    Full Text Available O artigo analisa as relações Brasil-África entre 2003 e 2006, procurando demonstrar que a eleição de Luiz Inácio Lula da Silva trouxe nova dinâmica às relações do Brasil com o continente africano. O discurso e a prática diplomática deste governo convergem para a construção de alianças preferenciais com parceiros no âmbito das relações Sul-Sul. Nesse contexto, defende-se que África do Sul, Angola e Nigéria são parceiros políticos e econômicos essenciais à estratégia diplomática brasileira para o continente africano.The article analyzes Brazil-Africa relations between 2003 and 2006, aiming to demonstrate that the election of Luiz Inácio Lula da Silva injected a new dynamic to Brazil's relations with the African continent. The discourse and diplomatic practice of the Lula government have combined to help build preferential alliances with partners within the arena of South-South relations. In this context the text argues that South Africa, Angola and Nigeria are essential political and economic partners in Brazil's diplomatic strategy for the African continent.

  12. Türkçe Öğretmenlerinin Okuma Yöntem-Tekniklerini ve Araç-Gereçlerini Kullanma Durumları The Using Conditions Of In Reading Methods-Techniques And Materials Of The Turkish Teachers'

    Fulya TOPÇUOĞLU ÜNAL

    2013-07-01

    questions methods are almost at the same rate; reading methods such as verbal choir, reading theatre and memorizing are used less frequently.Additionally, teachers use the teachers’ guidebook with 93% and the course book with 92%. Usage rates of spelling dictionary and dictionaries are very close to each other between the rates of 88-83%; and use of extracurricular reading books remains at 75%. Meanwhile, it was identified that participants do not use the technology in the reading field of Turkish language course, as the rate of use is marked at 67%.Silent and oral reading method emerges as the most used methods for male participants. While oral reading is also the most used method for female participants, association with text emerges as the second most used method. Reading Theater and memorizing methods are the two least used methods for both male and female participants. Türkçe dersi çok yönlü bir derstir. Bu bakımdan, bu dersle ilgili çalışmalar sırasında birden çok değişik yöntem ve tekniğe başvurulması hem doğal, hem de zorunludur. Türkçe Dersi Öğretim Programı’nda okuma, diğer becerilerin geliştirilmesi için temel olarak görülmüştür.Öğrenmenin etkili ve kalıcı olabilmesi için, öğrendiklerimiz birçok duyumuza hitap etmelidir. Bu anlamda okuma alanındaki yöntem-teknik ve araç-gereçler; analiz yapan, sorgulayan, sınıflayan, üreten bireyler olarak yetiştirilmemiz için kullanılmalıdır. Türkçe öğretimi, yalnızca dilsel metinlerle yürütülen bir süreç olmaktan çıkarılıp görsel, işitsel metinlerle de desteklenerek yürütülmelidir.Bu araştırmanın amacı, Türkçe öğretmenlerinin 7 ve 8. sınıf Türkçe öğretim programında yer alan okuma alanında kullanılması önerilen yöntem-teknikleri ve araç-gereçleri kullanma durumlarının belirlenmesidir. Araştırma tarama modelindedir. Araştırmanın örneklemi Bursa il merkezinde görev yapan 298 öğretmenden oluşmaktadır. Örnekleme y

  13. NNDSS - Table IV. Tuberculosis

    U.S. Department of Health & Human Services — NNDSS - Table IV. Tuberculosis - 2014.This Table includes total number of cases reported in the United States, by region and by states, in accordance with the...

  14. NNDSS - Table IV. Tuberculosis

    U.S. Department of Health & Human Services — NNDSS - Table IV. Tuberculosis - 2015.This Table includes total number of cases reported in the United States, by region and by states, in accordance with the...

  15. NNDSS - Table IV. Tuberculosis

    U.S. Department of Health & Human Services — NNDSS - Table IV. Tuberculosis - 2016.This Table includes total number of cases reported in the United States, by region and by states, in accordance with the...

  16. Interplanetary Type IV Bursts

    Hillaris, Alexander; Nindos, Alexander

    2016-01-01

    In this work we study the characteristics of moving type IV radio bursts which extend to the hectometric wavelengths (interplanetary type IV or type IV IP bursts) and their relationship with energetic phenomena on the Sun. Our dataset comprised 48 Interplanetary type IV bursts observed by the Wind/WAVES in the 13.825 MHz?20 KHz frequency range. The dynamic spec tra of the RSTN, DAM, ARTEMIS-IV, CULGOORA, Hiraiso and IZMIRAN Radio-spectrographs were used to track the evolution of the events in the low corona; these were supplemented with SXR ?ux recordings from GOES and CME data from LASCO. Positional information for the coronal bursts were obtained by the Nan\\c{c}ay radioheliograph (NRH). We examined the relationship of the type IV events with coronal radio bursts, CMEs and SXR ?ares. The majority of the events (45) were characterized as compact; their duration was on average 106 min. This type of events were, mostly, associated with M and X class ?ares (40 out of 45) and fast CMEs; 32 of these events had CME...

  17. Interplanetary Type IV Bursts

    Hillaris, A.; Bouratzis, C.; Nindos, A.

    2016-08-01

    We study the characteristics of moving type IV radio bursts that extend to hectometric wavelengths (interplanetary type IV or type {IV}_{{IP}} bursts) and their relationship with energetic phenomena on the Sun. Our dataset comprises 48 interplanetary type IV bursts observed with the Radio and Plasma Wave Investigation (WAVES) instrument onboard Wind in the 13.825 MHz - 20 kHz frequency range. The dynamic spectra of the Radio Solar Telescope Network (RSTN), the Nançay Decametric Array (DAM), the Appareil de Routine pour le Traitement et l' Enregistrement Magnetique de l' Information Spectral (ARTEMIS-IV), the Culgoora, Hiraso, and the Institute of Terrestrial Magnetism, Ionosphere and Radio Wave Propagation (IZMIRAN) Radio Spectrographs were used to track the evolution of the events in the low corona. These were supplemented with soft X-ray (SXR) flux-measurements from the Geostationary Operational Environmental Satellite (GOES) and coronal mass ejections (CME) data from the Large Angle and Spectroscopic Coronagraph (LASCO) onboard the Solar and Heliospheric Observatory (SOHO). Positional information of the coronal bursts was obtained by the Nançay Radioheliograph (NRH). We examined the relationship of the type IV events with coronal radio bursts, CMEs, and SXR flares. The majority of the events (45) were characterized as compact, their duration was on average 106 minutes. This type of events was, mostly, associated with M- and X-class flares (40 out of 45) and fast CMEs, 32 of these events had CMEs faster than 1000 km s^{-1}. Furthermore, in 43 compact events the CME was possibly subjected to reduced aerodynamic drag as it was propagating in the wake of a previous CME. A minority (three) of long-lived type {IV}_{{IP}} bursts was detected, with durations from 960 minutes to 115 hours. These events are referred to as extended or long duration and appear to replenish their energetic electron content, possibly from electrons escaping from the corresponding coronal

  18. IV access in dental practice.

    Fitzpatrick, J J

    2009-04-01

    Intravenous (IV) access is a valuable skill for dental practitioners in emergency situations and in IV sedation. However, many people feel some apprehension about performing this procedure. This article explains the basic principles behind IV access, and the relevant anatomy and physiology, as well as giving a step-by-step guide to placing an IV cannula.

  19. Marketing produktu Karel IV.

    Mikšů, Šárka

    2009-01-01

    Goal of the thesis Marketing of the product Karel IV. is to propose chanels of marketing communication and indicate possibilities of next product's development. Theoretical part is based on marketing plan and it's partition. In the practical part you can find market analysis and competing products analysis, product's evolution description and marketing research.

  20. Dibromidodimethyldipyridineplatinum(IV

    Mairéad E. Kelly

    2008-11-01

    Full Text Available In the title complex, [PtBr2(CH32(C5H5N2], the PtIV metal centre lies on a twofold rotation axis and adopts a slightly distorted octahedral coordination geometry. The structure displays weak intramolecular C—H...Br hydrogen-bonding interactions.

  1. PLATO IV Accountancy Index.

    Pondy, Dorothy, Comp.

    The catalog was compiled to assist instructors in planning community college and university curricula using the 48 computer-assisted accountancy lessons available on PLATO IV (Programmed Logic for Automatic Teaching Operation) for first semester accounting courses. It contains information on lesson access, lists of acceptable abbreviations for…

  2. Enhanced Design Alternative IV

    N. E. Kramer

    1999-05-18

    This report evaluates Enhanced Design Alternative (EDA) IV as part of the second phase of the License Application Design Selection (LADS) effort. The EDA IV concept was compared to the VA reference design using criteria from the ''Design Input Request for LADS Phase II EDA Evaluations'' (CRWMS M&O 1999b) and (CRWMS M&O 1999f). Briefly, the EDA IV concept arranges the waste packages close together in an emplacement configuration known as ''line load''. Continuous pre-closure ventilation keeps the waste packages from exceeding the 350 C cladding and 200 C (4.3.13) drift wall temperature limits. This EDA concept keeps relatively high, uniform emplacement drift temperatures (post-closure) to drive water away from the repository and thus dry out the pillars between emplacement drifts. The waste package is shielded to permit human access to emplacement drifts and includes an integral filler inside the package to reduce the amount of water that can contact the waste form. Closure of the repository is desired 50 years after first waste is emplaced. Both backfill and a drip shields will be emplaced at closure to improve post-closure performance.

  3. Diaquatetrabromidotin(IV trihydrate

    Fei Ye

    2012-09-01

    Full Text Available The title compound, [SnBr4(H2O2]·3H2O, forms large colourless crystals in originally sealed samples of tin tetrabromide. It constitutes the first structurally characterized hydrate of SnBr4 and is isostructural with the corresponding hydrate of SnCl4. It is composed of SnIV atoms octahedrally coordinated by four Br atoms and two cis-related water molecules. The octahedra exhibit site symmetry 2. They are arranged into columns along [001] via medium–strong O—H...O hydrogen bonds involving the two lattice water molecules (one situated on a twofold rotation axis while the chains are interconnected via longer O—H...Br hydrogen bonds, forming a three-dimensional network.

  4. Phase IV of Drug Development

    Viraj Suvarna

    2010-01-01

    Not all Phase IV studies are post-marketing surveillance (PMS) studies but every PMS study is a phase IV study. Phase IV is also an important phase of drug development. In particular, the real world effectiveness of a drug as evaluated in an observational, non-interventional trial in a naturalistic setting which complements the efficacy data that emanates from a pre-marketing randomized controlled trial (RCT). No matter how many patients are studied pre-marketing in a controlled environment, ...

  5. Confirmatory Factor Analysis of the WAIS-IV/WMS-IV

    Holdnack, James A.; Zhou, Xiaobin; Larrabee, Glenn J.; Millis, Scott R.; Salthouse, Timothy A.

    2011-01-01

    The Wechsler Adult Intelligence Scale-fourth edition (WAIS-IV) and the Wechsler Memory Scale-fourth edition (WMS-IV) were co-developed to be used individually or as a combined battery of tests. The independent factor structure of each of the tests has been identified; however, the combined factor structure has yet to be determined. Confirmatory…

  6. Nyankomne asylansøgeres helbredsstatus og traumatiseringsgrad--sekundaerpublikation

    Masmas, Tania Nicole; Møller, Eva; Buhmann, Caecilie;

    2010-01-01

    non-tortured asylum seekers. Among the torture survivors, 63% fulfilled the criteria of post-traumatic stress disorder, 58% had objective psychological findings, and 42% had torture-related scars. Identification of torture survivors is important in order to initiate the necessary medical treatment...

  7. Selvmordsforsøgeres kontakt til den primaere sundhedssektor

    Jensen, Børge Frank; Christiansen, Erik

    2005-01-01

    We examined suicide attempters' use of health insurance services as part of an effort to prevent suicidal behaviour.......We examined suicide attempters' use of health insurance services as part of an effort to prevent suicidal behaviour....

  8. DSM-IV Progress Report.

    Hohenshil, Thomas H.

    1992-01-01

    Notes that Diagnostic and Statistical Manual of Mental Disorders fourth edition (DSM-IV) will become one of most frequently used reference documents in counseling profession. Describes progress being made in development of DSM-IV, scheduled for publication in 1994. Describes revision process and proposed organizational changes and new diagnostic…

  9. Aqueous complexation of thorium(IV), uranium(IV), neptunium(IV), plutonium(III/IV), and cerium(III/IV) with DTPA.

    Brown, M Alex; Paulenova, Alena; Gelis, Artem V

    2012-07-16

    Aqueous complexation of Th(IV), U(IV), Np(IV), Pu(III/IV), and Ce(III/IV) with DTPA was studied by potentiometry, absorption spectrophotometry, and cyclic voltammetry at 1 M ionic strength and 25 °C. The stability constants for the 1:1 complex of each trivalent and tetravalent metal were calculated. From the potentiometric data, we report stability constant values for Ce(III)DTPA, Ce(III)HDTPA, and Th(IV)DTPA of log β(101) = 20.01 ± 0.02, log β(111) = 22.0 ± 0.2, and log β(101) = 29.6 ± 1, respectively. From the absorption spectrophotometry data, we report stability constant values for U(IV)DTPA, Np(IV)DTPA, and Pu(IV)DTPA of log β(101) = 31.8 ± 0.1, 32.3 ± 0.1, and 33.67 ± 0.02, respectively. From the cyclic voltammetry data, we report stability constant values for Ce(IV) and Pu(III) of log β(101) = 34.04 ± 0.04 and 20.58 ± 0.04, respectively. The values obtained in this work are compared and discussed with respect to the ionic radius of each cationic metal.

  10. NCCOS IKONOS Imagery for the Republic of Palau, 2003-2006

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Oceanic & Atmospheric Administration's (NOAA) National Ocean Service (NOS) is tasked with the coral mapping element of the U.S. Coral Reef Task...

  11. A case study of speculative financial bubbles in the South African stock market 2003-2006

    Zhou, W X; Sornette, Didier; Zhou, Wei-Xing

    2007-01-01

    We tested 45 indices and common stocks traded in the South African stock market for the possible existence of a bubble over the period from Jan. 2003 to May 2006. A bubble is defined by a faster-than-exponential acceleration with significant log-periodic oscillations. The faster-than-exponential acceleration characteristics are tested with several different metrics, including nonlinearity on the logarithm of the price and power law fits. The log-periodic properties are investigated in detail using the first-order log-periodic power-law (LPPL) formula, the parametric detrending method, the $(H,q)$-analysis, and the second-order Weierstrass-type model, resulting in a consistent and robust estimation of the fundamental angular log-frequency $\\omega_1 =7\\pm 2$, in reasonable agreement with previous estimations on many other bubbles in developed and developing markets. Sensitivity tests of the estimated critical times and of the angular log-frequency are performed by varying the first date and the last date of the...

  12. The epidemiology of breast cancer in French Guiana 2003-2006.

    Roue, Tristan; Fior, Angela; Plenet, Juliette; Belliardo, Sophie; Nacher, Mathieu

    2013-01-01

    For the first time the incidence and mortality of breast cancer were estimated in French Guiana, an overseas French Territory of South America. A certified cancer registry collected exhaustive data on breast cancer between 2003 and 2005. The age-standardized rate of breast cancer was 47.1 per 100 000 women. The age-standardized death rate was 11.0 per 100 000 women. Although the standardized incidence and death rates were lower than in metropolitan France and South America, the ratio between incidence and mortality showed that the prognosis of breast cancer in French Guiana was worse than in metropolitan France (23 deaths per 100 incident cases versus 17 deaths per 100 incident cases, respectively). The demographics of French Guiana, suggests that mass organized screening may benefit from lowering the age of its target population.

  13. U.S. Marine Corps Operations in Iraq, 2003-2006

    2009-01-01

    Brigade, 1st Infantry Division, patrolled the area of operations Topeka. Colonel Arthur W. “ Buck ” Conner Jr., U.S. Army, deployed his 1st Battalion...15 RPG propellants 5 RPG boosters 4 Powder bags 5 Primers 8 These results remained typical throughout the campaign of 2004–2005 for that level of

  14. Restoring Anadromous Fish Habitat in the Lapwai Creek Watershed, Technical Report 2003-2006.

    Rasmussen, Lynn

    2007-02-01

    The Restoring Anadromous Fish Habitat in the Lapwai Creek Watershed is a multi-phase project to enhance steelhead trout in the Lapwai Creek watershed by improving salmonid spawning and rearing habitat. Habitat is limited by extreme high runoff events, low summer flows, high water temperatures, poor instream cover, spawning gravel siltation, and sediment, nutrient and bacteria loading. Funded by the Bonneville Power Administration (BPA) as part of the Northwest Power Planning Council's Fish and Wildlife Program, the project assists in mitigating damage to steelhead runs caused by the Columbia River hydroelectric dams. The project is sponsored by the Nez Perce Soil and Water Conservation District (District). Target fish species include steelhead trout (Oncorhynchus mykiss). Steelhead trout within the Snake River Basin were listed in 1997 as threatened under the Endangered Species Act. Accomplishments for the contract period December 1, 2003 through February 28, 2004 include; seven grade stabilization structures, 0.67 acres of wetland plantings, ten acres tree planting, 500 linear feet streambank erosion control, two acres grass seeding, and 120 acres weed control.

  15. Teaching medical ethics to undergraduate students in post-apartheid South Africa, 2003 2006.

    Moodley, Keymanthri

    2007-11-01

    The apartheid ideology in South Africa had a pervasive influence on all levels of education including medical undergraduate training. The role of the health sector in human rights abuses during the apartheid era was highlighted in 1997 during the Truth and Reconciliation Commission hearings. The Health Professions Council of South Africa (HPCSA) subsequently realised the importance of medical ethics education and encouraged the introduction of such teaching in all medical schools in the country. Curricular reform at the University of Stellenbosch in 1999 presented an unparalleled opportunity to formally introduce ethics teaching to undergraduate students. This paper outlines the introduction of a medical ethics programme at the Faculty of Health Sciences from 2003 to 2006, with special emphasis on the challenges encountered. It remains one of the most comprehensive undergraduate medical ethics programmes in South Africa. However, there is scope for expanding the curricular time allocated to medical ethics. Integrating the curriculum both horizontally and vertically is imperative. Implementing a core curriculum for all medical schools in South Africa would significantly enhance the goals of medical education in the country.

  16. TOPICAL REVIEW: A review of power harvesting using piezoelectric materials (2003 2006)

    Anton, Steven R.; Sodano, Henry A.

    2007-06-01

    The field of power harvesting has experienced significant growth over the past few years due to the ever-increasing desire to produce portable and wireless electronics with extended lifespans. Current portable and wireless devices must be designed to include electrochemical batteries as the power source. The use of batteries can be troublesome due to their limited lifespan, thus necessitating their periodic replacement. In the case of wireless sensors that are to be placed in remote locations, the sensor must be easily accessible or of a disposable nature to allow the device to function over extended periods of time. Energy scavenging devices are designed to capture the ambient energy surrounding the electronics and convert it into usable electrical energy. The concept of power harvesting works towards developing self-powered devices that do not require replaceable power supplies. A number of sources of harvestable ambient energy exist, including waste heat, vibration, electromagnetic waves, wind, flowing water, and solar energy. While each of these sources of energy can be effectively used to power remote sensors, the structural and biological communities have placed an emphasis on scavenging vibrational energy with piezoelectric materials. This article will review recent literature in the field of power harvesting and present the current state of power harvesting in its drive to create completely self-powered devices.

  17. NCCOS Shoreline for the Republic of Palau - Derived from IKONOS Imagery, 2003-2006

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  18. Large-Scale Submerged Aquatic Vegetation Restoration in Chesapeake Bay: Status Report, 2003-2006

    2008-06-01

    marina), (2) wild celery (V. americana), (3) sago pondweed (S. pectinata), and (4) redhead grass (P. perfoliatus). Molecular and cultivation...depth and density on germination and development of Zostera marina L. seeds. Biologia Marina Mediterranea 7(3):55–58. Granger, S., M. Traber, S. W...sago pondweed (S. pectinata), and redhead grass (P. perfoliatus) collected from different regions of the Chesapeake Bay. Molecular and cultivation

  19. Factores De Riesgo Para Parto Pretermino En El Departamento De Caldas Entre El 2003-2006

    Arango, Maria del Pilar; Gineco-Obstetra, Docente Gineco-obstetricia, F. de Medicina, Universidad de Manizales.; Aroca Gonzalez, Ana Maria; Estudiante 10º Semestre, Facultad de Medicina, Universidad de Manizales.; Caicedo Pastrana, Claudia Lorena; Gineco-Obstetra, Docente Gineco-obstetricia, F. de Medicina, Universidad de Manizales.; Castaño Berdawil, Ricardo Elias; Gineco-Obstetra, Docente Gineco-obstetricia, F. de Medicina, Universidad de Manizales.; Castaño Castrillón, Jose Jaime; Profesor Asociado, Director Centro de Investigaciones, F. de Medicina, U. de Manizales. Cra 9 # 19-03, Manizales, Caldas, teléfono 8841450. Correo :; Cifuentes Navas, Viviana Andrea; Gineco-Obstetra, Docente Gineco-obstetricia, F. de Medicina, Universidad de Manizales.; Escobar Cardona, Natalia; Gineco-Obstetra, Docente Gineco-obstetricia, F. de Medicina, Universidad de Manizales.; Giraldo Galvis, Jairo Alonso; Gineco-Obstetra, Docente Gineco-obstetricia, F. de Medicina, Universidad de Manizales.; Lopez, Irma Rocio; Estudiante 10º Semestre, Facultad de Medicina, Universidad de Manizales.

    2008-01-01

    Preterm deliveries include births before a gestational age of 37 weeks. It’s from unknownetiology and seems to be a multi-factorial pathology, which worldwide is recognized asthe first cause of prenatal morbidity and mortality.Objective: To identify risk factors for preterm deliveries in the pregnant women of thedepartments of Caldas between the years 2003 and 2006.Materials and Methods: A descriptive retrospective study was made of cases andcontrols in local hospitals of the Republica Hospit...

  20. Confirmatory factor analysis of the WAIS-IV/WMS-IV.

    Holdnack, James A; Xiaobin Zhou; Larrabee, Glenn J; Millis, Scott R; Salthouse, Timothy A

    2011-06-01

    The Wechsler Adult Intelligence Scale-fourth edition (WAIS-IV) and the Wechsler Memory Scale-fourth edition (WMS-IV) were co-developed to be used individually or as a combined battery of tests. The independent factor structure of each of the tests has been identified; however, the combined factor structure has yet to be determined. Confirmatory factor analysis was applied to the WAIS-IV/WMS-IV Adult battery (i.e., age 16-69 years) co-norming sample (n = 900) to test 13 measurement models. The results indicated that two models fit the data equally well. One model is a seven-factor solution without a hierarchical general ability factor: Verbal Comprehension, Perceptual Reasoning, Processing Speed, Auditory Working Memory, Visual Working Memory, Auditory Memory, and Visual Memory. The second model is a five-factor model composed of Verbal Comprehension, Perceptual Reasoning, Processing Speed, Working Memory, and Memory with a hierarchical general ability factor. Interpretative implications for each model are discussed.

  1. Contribution of alpha3(IV)alpha4(IV)alpha5(IV) Collagen IV to the Mechanical Properties of the Glomerular Basement Membrane

    Gyoneva, Lazarina

    The glomerular basement membrane (GBM) is a vital part of the blood-urine filtration barrier in the kidneys. In healthy GBMs, the main tension-resisting component is alpha3(IV)alpha4(IV)alpha5(IV) type IV collagen, but in some diseases it is replaced by other collagen IV isoforms. As a result, the GBM becomes leaky and disorganized, ultimately resulting in kidney failure. Our goal is to understanding the biomechanical aspects of the alpha3(IV)alpha4(IV)alpha5(IV) chains and how their absence could be responsible for (1) the initial injury to the GBM and (2) progression to kidney failure. A combination of experiments and computational models were designed for that purpose. A model basement membrane was used to compare experimentally the distensibility of tissues with the alpha3(IV)alpha4(IV)alpha5(IV) chains present and missing. The experiments showed basement membranes containing alpha3(IV)alpha4(IV)alpha5(IV) chains were less distensible. It has been postulated that the higher level of lateral cross-linking (supercoiling) in the alpha3(IV)alpha4(IV)alpha5(IV) networks contributes additional strength/stability to basement membranes. In a computational model of supercoiled networks, we found that supercoiling greatly increased the stiffness of collagen IV networks but only minimally decreased the permeability, which is well suited for the needs of the GBM. It is also known that the alpha3(IV)alpha4(IV)alpha5(IV) networks are more protected from enzymatic degradation, and we explored their significance in GBM remodeling. Our simulations showed that the more protected network was needed to prevent the system from entering a dangerous feedback cycle due to autoregulation mechanisms in the kidneys. Overall, the work adds to the evidence of biomechanical differences between the alpha3(IV)alpha4(IV)alpha5(IV) networks and other collagen IV networks, points to supercoiling as the main source of biomechanical differences, discusses the suitability of alpha3(IV)alpha4(IV

  2. Free-format RPG IV

    Martin, Jim

    2013-01-01

    This how-to guide offers a concise and thorough introduction to the increased productivity, better readability, and easier program maintenance that comes with the free-format style of programming in RPG IV. Although free-format information is available in IBM manuals, it is not separated from everything else, thereby requiring hours of tedious research to track down the information needed. This book provides everything one needs to know to write RPG IV in the free-format style, and author Jim Martin not only teaches rules and syntax but also explains how this new style of coding has the pot

  3. Phase IV of Drug Development.

    Suvarna, Viraj

    2010-04-01

    Not all Phase IV studies are post-marketing surveillance (PMS) studies but every PMS study is a phase IV study. Phase IV is also an important phase of drug development. In particular, the real world effectiveness of a drug as evaluated in an observational, non-interventional trial in a naturalistic setting which complements the efficacy data that emanates from a pre-marketing randomized controlled trial (RCT). No matter how many patients are studied pre-marketing in a controlled environment, the true safety profile of a drug is characterized only by continuing safety surveillance through a spontaneous adverse event monitoring system and a post-marketing surveillance/non-interventional study. Prevalent practice patterns can generate leads that could result in further evaluation of a new indication via the RCT route or even a signal that may necessitate regulatory action (change in labeling, risk management/minimization action plan). Disease registries are another option as are the large simple hybrid trials. Surveillance of spontaneously reported adverse events continues as long as a product is marketed. And so Phase IV in that sense never ends.

  4. Phase IV of Drug Development

    Viraj Suvarna

    2010-01-01

    Full Text Available Not all Phase IV studies are post-marketing surveillance (PMS studies but every PMS study is a phase IV study. Phase IV is also an important phase of drug development. In particular, the real world effectiveness of a drug as evaluated in an observational, non-interventional trial in a naturalistic setting which complements the efficacy data that emanates from a pre-marketing randomized controlled trial (RCT. No matter how many patients are studied pre-marketing in a controlled environment, the true safety profile of a drug is characterized only by continuing safety surveillance through a spontaneous adverse event monitoring system and a post-marketing surveillance/non-interventional study. Prevalent practice patterns can generate leads that could result in further evaluation of a new indication via the RCT route or even a signal that may necessitate regulatory action (change in labeling, risk management/minimization action plan. Disease registries are another option as are the large simple hybrid trials. Surveillance of spontaneously reported adverse events continues as long as a product is marketed. And so Phase IV in that sense never ends.

  5. VeVeRa-IV

    Evelien Eggink; Debbie Oudijk; Klarita Sadiraj

    2012-01-01

    Original title: VeVeRa-IV The Dutch population is set to age rapidly in the coming years. More and more people will also attain a very great age. This means that the need for home care and care provided in nursing or residential care homes will also increase. As part of the Long-term Care Programme

  6. Alle har en historie, IV

    Ydegaard, Torbjørn

    Alle har en historie IV: Pædagogik med Freedom Writers lader et væld af pædagogiske facetter udspringe af den kendte skole-film Freedom Writers’ scener og handlinger. Der er både fokus på en almen tilgang til pædagogik og på Freedom Writer-metodikken, dels gennem de filmscener, der sættes til...

  7. Test Review: Advanced Clinical Solutions for WAIS-IV and WMS-IV

    Chu, Yiting; Lai, Mark H. C.; Xu, Yining; Zhou, Yuanyuan

    2012-01-01

    The authors review the "Advanced Clinical Solutions for WAIS-IV and WMS-IV". The "Advanced Clinical Solutions (ACS) for the Wechsler Adult Intelligence Scale-Fourth Edition" (WAIS-IV; Wechsler, 2008) and the "Wechsler Memory Scale-Fourth Edition" (WMS-IV; Wechsler, 2009) was published by Pearson in 2009. It is a…

  8. Test Review: Advanced Clinical Solutions for WAIS-IV and WMS-IV

    Chu, Yiting; Lai, Mark H. C.; Xu, Yining; Zhou, Yuanyuan

    2012-01-01

    The authors review the "Advanced Clinical Solutions for WAIS-IV and WMS-IV". The "Advanced Clinical Solutions (ACS) for the Wechsler Adult Intelligence Scale-Fourth Edition" (WAIS-IV; Wechsler, 2008) and the "Wechsler Memory Scale-Fourth Edition" (WMS-IV; Wechsler, 2009) was published by Pearson in 2009. It is a clinical tool for extending the…

  9. Report on the O IV and S IV lines observed by IRIS

    Young, Peter R

    2015-01-01

    The O IV intercombination lines observed by the Interface Region Imaging Spectrograph (IRIS) between 1397 and 1407 A provide useful density diagnostics. This document presents data that address two issues related to these lines: (1) the contribution of S IV to the O IV 1404.8 line; and (2) the range of sensitivity of the O IV 1399.8/1401.2 ratio.

  10. IVS contribution to ITRF2014

    Bachmann, Sabine; Thaller, Daniela; Roggenbuck, Ole; Lösler, Michael; Messerschmitt, Linda

    2016-07-01

    Every few years the International Terrestrial Reference System (ITRS) Center of the International Earth Rotation and Reference Systems Service (IERS) decides to generate a new version of the International Terrestrial Reference Frame (ITRF). For the upcoming ITRF2014 the official contribution of the International VLBI Service for Geodesy and Astrometry (IVS) comprises 5796 combined sessions in SINEX file format from 1979.6 to 2015.0 containing 158 stations, overall. Nine AC contributions were included in the combination process, using five different software packages. Station coordinate time series of the combined solution show an overall repeatability of 3.3 mm for the north, 4.3 mm for the east and 7.5 mm for the height component over all stations. The minimum repeatabilities are 1.5 mm for north, 2.1 mm for east and 2.9 mm for height. One of the important differences between the IVS contribution to the ITRF2014 and the routine IVS combination is the omission of the correction for non-tidal atmospheric pressure loading (NTAL). Comparisons between the amplitudes of the annual signals derived by the VLBI observations and the annual signals from an NTAL model show that for some stations, NTAL has a high impact on station height variation. For other stations, the effect of NTAL is low. Occasionally other loading effects have a higher influence (e.g. continental water storage loading). External comparisons of the scale parameter between the VTRF2014 (a TRF based on combined VLBI solutions), DTRF2008 (DGFI-TUM realization of ITRS) and ITRF2008 revealed a significant difference in the scale. A scale difference of 0.11 ppb (i.e. 0.7 mm on the Earth's surface) has been detected between the VTRF2014 and the DTRF2008, and a scale difference of 0.44 ppb (i.e. 2.8 mm on the Earth's surface) between the VTRF2014 and ITRF2008. Internal comparisons between the EOP of the combined solution and the individual solutions from the AC contributions show a WRMS in X- and Y-Pole between

  11. IVS Working Group 4: VLBI Data Structures

    Gipson, John

    2010-01-01

    In 2007 the IVS Directing Board established IVS Working Group 4 on VLBI Data Structures. This note discusses the current VLBI data format, goals for a new format, the history and formation of the Working Group, and a timeline for the development of a new VLBI data format.

  12. Stark broadening of B IV spectral lines

    Dimitrijevic, Milan S; Simic, Zoran; Kovacevic, Andjelka; Sahal-Brechot, Sylvie

    2016-01-01

    Stark broadening parameters for 157 multiplets of helium like boron (B IV) have been calculated using the impact semiclassical perturbation formalism. Obtained results have been used to investigate the regularities within spectral series. An example of the influence of Stark broadening on B IV lines in DO white dwarfs is given.

  13. Metsahovi Radio Observatory - IVS Network Station

    Uunila, Minttu; Zubko, Nataliya; Poutanen, Markku; Kallunki, Juha; Kallio, Ulla

    2013-01-01

    In 2012, Metsahovi Radio Observatory together with Finnish Geodetic Institute officially became an IVS Network Station. Eight IVS sessions were observed during the year. Two spacecraft tracking and one EVN X-band experiment were also performed. In 2012, the Metsahovi VLBI equipment was upgraded with a Digital Base Band Converter, a Mark 5B+, a FILA10G, and a FlexBuff.

  14. Thermodynamic data for predicting concentrations of Th(IV), U(IV), Np(IV), and Pu(IV) in geologic environments

    Rai, Dhanpat; Roa, Linfeng; Weger, H.T.; Felmy, A.R. [Battelle, Pacific Northwest National Laboratory (PNNL) (United States); Choppin, G.R. [Florida State University (United States); Yui, Mikazu [Waste Isolation Research Division, Tokai Works, Japan Nuclear Cycle Development Inst., Tokai, Ibaraki (Japan)

    1999-01-01

    This report provides thermodynamic data for predicting concentrations of Th(IV), U(IV), Np(IV), and Pu(IV) in geologic environments, and contributes to an integration of the JNC chemical thermodynamic database, JNC-TDB (previously PNC-TDB), for the performance analysis of geological isolation system for high-level radioactive wastes. Thermodynamic data for the formation of complexes or compounds with hydroxide, chloride, fluoride, carbonate, nitrate, sulfate and phosphate are discussed in this report. Where data for specific actinide(IV) species was lacking, the data were selected based on chemical analogy to other tetravalent actinides. In this study, the Pitzer ion-interaction model is used to extrapolate thermodynamic constants to zero ionic strength at 25degC. (author)

  15. European Energy Law. Report IV

    Hammer, U.; Roggenkamp, M.M. (eds.)

    2007-07-01

    The European Energy Law Report IV presents an overview of the most important legal developments in the field of EU and national energy law as discussed at the 2006 European Energy Law Seminar. It examines recent developments in EU and National Law affecting the energy sector. This includes the increasing use of EU competition law to liberalise the energy markets, the long-awaited implementation of the 2003 Electricity and Gas Directives in Germany and an assessment of Regulation 1775/2005 and its effect on the European gas market. Besides the energy market liberalisation, the Community is increasingly paying attention to the need for a sustainable and clean energy supply. The second part of the book therefore includes chapters on legal issues resulting from the experiences on emission trading in 2005-2007, the regulatory challenges resulting from the new Commission Energy Policy, the impact of the Amsterdam and Berlin Fora on EU Energy policy, and the EU policy framework on energy efficiency. An important tool for improving energy efficiency is the introduction of white certificates. The third part of the report presents the basic principles of white certificates as well as practical experiences and policies in some member states like Italy, France, The Netherlands and the UK. The final part of the report considers several issues related to the development and use of subsea electricity interconnectors and pays special attention to the development of the NorNed cable. It raises the need for a Treaty perspective on the developments of such subsea interconnectors. Then some regulatory views on the development of the NorNed cable and market coupling through the cable are presented. Finally, the economic and regulatory distinction between regulated and merchant interconnectors is discussed.

  16. Surprising Coordination Geometry Differences in Ce(IV)- and Pu(IV)-Maltol Complexes

    Lawrence Berkeley National Laboratory; Raymond, Kenneth; Szigethy, Geza; Xu, Jide; Gorden, Anne E.V.; Teat, Simon J.; Shuh, David K.; Raymond, Kenneth N.

    2008-02-12

    As part of a study to characterize the detailed coordination behavior of Pu(IV), single crystal X-ray diffraction structures have been determined for Pu(IV) and Ce(IV) complexes with the naturally-occurring ligand maltol (3-hydroxy-2-methyl-pyran-4-one) and its derivative bromomaltol (5-bromo-3-hydroxy-2-methyl-pyran-4-one). Although Ce(IV) is generally accepted as a structural analog for Pu(IV), and the maltol complexes of these two metals are isostructural, the corresponding bromomaltol complexes are strikingly different with respect to ligand orientation about the metal ion: All complexes exhibit trigonal dodecahedral coordination geometry but the Ce(IV)-bromomaltol complex displays an uncommon ligand arrangement not mirrored in the Pu(IV) complex, although the two metal species are generally accepted to be structural analogs.

  17. Atmosphere of Mars - Mariner IV models compared.

    Eshleman, V. R.; Fjeldbo, G.; Fjeldbo, W. C.

    1966-01-01

    Mariner IV models of three Mars atmospheric layers analogous to terrestrial E, F-1 and F-2 layers, considering relative mass densities, temperatures, carbon dioxide photodissociation and ionization profile

  18. Periodontal Disease Part IV: Periodontal Infections

    Turnbull, Robert S.

    1988-01-01

    In Part IV of this article, the author describes two periodontal infections, acute necrotizing ulcerative gingivitis (trench mouth) and periodontal abscess, both acute painful conditions for which patients may seek advice from their family physician rather than their dentist.

  19. Comparison of Russian and IVS intensive series

    Kurdubov, S. L.

    2013-08-01

    The article presents results of first comparison the Russian National UT1-UTC estimation program Ru-U and IVS-intensive international campaign. It is shown that the Ru-U sessions are performing with good accuracy and results can be included into international VLBI data processing scheme. Comparison of different distributions shows that the problem of correlation lack between single delay formal errors and UT1 estimations are presented both in Ru-U and IVS-intensive series.

  20. Observational properties of decameter type IV bursts

    Melnik, Valentin; Brazhenko, Anatoly; Rucker, Helmut; Konovalenko, Alexander; Briand, Carine; Dorovskyy, Vladimir; Zarka, Philippe; Frantzusenko, Anatoly; Panchenko, Michael; Poedts, Stefan; Zaqarashvili, Teimuraz; Shergelashvili, Bidzina

    2013-04-01

    Oscillations of decameter type IV bursts were registered during observations of solar radio emission by UTR-2, URAN-2 and NDA in 2011-2012. Large majority of these bursts were accompanied by coronal mass ejections (CMEs), which were observed by SOHO and STEREO in the visible light. Only in some cases decameter type IV bursts were not associated with CMEs. The largest periods of oscillations P were some tens of minutes. There were some modes of long periods of oscillations simultaneously. Periods of oscillations in flux and in polarization profiles were close. Detailed properties of oscillations at different frequencies were analyzed on the example of two type IV bursts. One of them was observed on April 7, 2011 when a CME happened. Another one (August 1, 2011) was registered without any CME. The 7 April type IV burst had two periods in the frames 75-85 and 35-85 minutes. Interesting feature of these oscillations is decreasing periods with time. The observed decreasing rates dP/dt equaled 0.03-0.07. Concerning type IV burst observed on August 1, 2011 the period of its oscillations increases from 17 min. at 30 MHz to 44 min. at 10 MHz. Connection of type IV burst oscillations with oscillations of magnetic arches and CMEs at corresponding altitudes are discussed. The work is fulfilled in the frame of FP7 project "SOLSPANET".

  1. La influenza en Costa Rica 2003-2006, un tema fundamental para la vigilancia epidemiológica actual Influenza in Costa Rica 2003-2006, a fundamental issue for the current epidemiological surveillance

    Karla Patricia Carvajal Muñoz

    2010-06-01

    Full Text Available Anualmente la influenza causa aproximadamente 3,5 millones de casos severos en el mundo. Objetivo: Describir y analizar la situación epidemiológica de la influenza y apoyar el fortalecimiento de su sistema de vigilancia. Métodos: Estudio descriptivo retrospectivo. Se calculó incidencia, riesgo relativo (RR, intervalo de confianza al 95 % (IC 95 % y número de egresos con sus promedios móviles, tasas de egreso hospitalario de influenza y neumonía. Fuentes de datos: los registros de notificación colectiva del Ministerio de Salud, la base de datos de egresos hospitalarios del Seguro Social y los registros de la vigilancia centinela del Centro Nacional de Influenza. Resultados: La incidencia anual mostró tendencia al aumento (R2 = 0,9 con picos en marzo a abril, junio a septiembre y agosto a diciembre. Las tasas anuales de egreso hospitalario mostraron tendencia a disminuir (R2 =0,9 con picos en marzo a mayo, julio a septiembre y septiembre a octubre. El pico de aislamientos del laboratorio se presentó en el segundo semestre de cada año, más frecuente en los meses de julio, agosto y septiembre. Discusión: Se cotejaron los datos de la vigilancia, los egresos hospitalarios y el laboratorio, los resultados no fueron suficientes para concluir si la influenza muestra estacionalidad. Se sugiere realizar un estudio del sistema de vigilancia de influenza para mejorar la calidad y el registro de los datos ya que es fundamental conocer la estacionalidad de la influenza y sus cambios para respaldar las intervenciones correspondientes y sus modificaciones.Influenza causes approximately 3,5 million cases of severe illness each year worldwide. Objective: To describe and analyze the influenza epidemiological situation in the past four years in order to support enhancement of the influenza surveillance system in Costa Rica. Methods: A descriptive, retrospective study was conducted. Incidence and hospital discharge rates were calculated. Sources of data were: collective notification forms of the Ministry of Health, the hospital discharge data base of the Costa Rican Social Security system as well as the influenza surveillance forms of the National Influenza Center. Results: Since 2005 collective information has been gathered monthly, by province, by age-groups and sex. From 2005 through 2006, the highest rates were found in the months of March and May. Regarding hospital discharges, mobile averages showed that a peak was reached between June and September. Laboratory diagnoses were highest during the months of July through September. Discussion: Collective notification is higher in the first semester; nevertheless, hospital discharge rates are higher between June and September which match the peak reached by laboratory diagnoses for influenza virus; this may suggest seasonality but there is a lack of robust data to confirm this; therefore, we suggest conducting further seasonality studies. This study supports the development of guidelines for the influenza surveillance process in Costa Rica.

  2. Axis IV--psychosocial and environmental problems--in the DSM-IV.

    Ramirez, A; Ekselius, L; Ramklint, M

    2013-11-01

    The aim of this study was to further explore the properties of axis IV in the Diagnostic and statistical manual of mental disorders, 4th edition (DSM-IV). In a naturalistic cross-sectional design, a group (n = 163) of young (18-25 years old) Swedish psychiatric outpatients was assessed according to DSM-IV. Psychosocial and environmental problems/axis IV were evaluated through structured interviewing by a social worker and by self-assessment on a questionnaire. Reliability between professional assessment and self-assessment of axis IV was examined. Concurrent validity of axis IV was also examined. Reliability between professional and self-assessed axis IV was fair to almost perfect, 0.31-0.83, according to prevalence and bias-adjusted kappa. Categories of psychosocial stress and environmental problems were related to the presence of axis I disorders, co-morbidity, personality disorders and decreasing Global Assessment of Functioning (GAF) values. The revised axis IV according to DSM-IV seems to have concurrent validity, but is still hampered by limited reliability.

  3. Estudio descriptivo de la enfermedad cerebrovascular en el Hospital Regional Docente de Ica-Perú 2003 - 2006

    J. Jhonnel Alarco

    2009-01-01

    Full Text Available Objetivo, Determinar algunas características epidemiológicas de la enfermedad cerebro vascular (ECV, describir las características de la población estudiada según sexo, edad, procedencia, raza, forma de inicio, ubicación, tipos y subtipos, síntomas, antecedentes patológicos y mortalidad intrahospitalaria. Materiales y métodos, estudio descriptivo. Lugar, Hospital Regional Docente de Ica. Criterios de inclusión, pacientes ingresados con diagnóstico de accidente cerebrovascular. Intervenciones, revisión de historias clínicas de archivo entre los años 2003 y 2006 Principales medidas de resultados, análisis estadístico, porcentajes y medidas de tendencia central, tabuladas en una base de datos con ayuda del programa Microsoft Excel 2003 para Windows®. Resultados, de 152 pacientes ingresados al servicio de Medicina 119 fueron casos de ECV isquémico, 33 casos fueron ECV hemorrágico. El principal antecedente patológico fue la hipertensión arterial con un 75.0 %. El síntoma más frecuente fue el trastorno motor con 80.3% seguido por alteraciones del lenguaje con 55.9%. El mayor número fue encontrado entre la séptima y octava décadas de la vida. La edad mínima fue de 17 y máxima de 102 años. La mortalidad global fue de 18 casos obteniéndose una tasa de letalidad específica para el ECV isquémico de 0,8% y de 51,5% para el ECV hemorrágico. Conclusiones: Se distingue a la HTA como el principal antecedente modificable, cuya prevención reduciría notablemente su mortalidad.

  4. Prevalence of Feeding Related Issues/Difficulties in Taiwanese Children with History of Prematurity, 2003-2006

    Howe, Tsu-Hsin; Hsu, Chyong-Hsin; Tsai, Mei-Wun

    2010-01-01

    Feeding problems are common problems seen in premature infants following their discharge from the NICU. However, the prevalence of feeding issues and failure to thrive among preterm infants in Taiwan is uncertain. All former studies of prevalence and identifications of feeding issues were from western countries. Those findings are therefore not…

  5. An Unmastered Past: Latvia and Russia After NATO and EU Enlargement: Bilateral Issues of Statecraft 2003-2006

    2006-06-01

    Supreme Soviet of Latvian SSR, cited in Dietrich Loeber Russian-Latvian Territorial Dispute Over Abrene, The Parker School Jounal of International Law, Vol...Dietrich, Russian- Latvian Territorial Dispute Over Abrene, The Parker School Jounal of International Law, Vol. 2, 1995. Malia, Martin, The Soviet

  6. Fruit juice consumption decreases the proportion of children with inadequate intakes of key nutrients: NHANES 2003-2006

    Fruit juice (FJ) consumption has been under scrutiny despite its nutrient profile. NHANES (2003–2006) data were used to compare the proportion of children ages 2–18 years with intakes of selected vitamins/minerals below recommended levels among consumers (n = 3,976; 51% females) and non-consumers (n...

  7. Improved nutrient intake and diet quality with 100% fruit juice consumption in children: NHANES 2003-2006

    Fruit juice (FJ) consumption has recently been viewed as a sweetened beverage with little regard to its nutrient contribution to the diet. NHANES, 2003–2006, data were used to examine the association of 100% FJ consumption, with nutrient intake and diet quality in children ages 2–5 y (n equals 1,665...

  8. Race, Urban Context, and Russian Roulette: Findings from the National Violent Death Reporting System, 2003-2006

    Wasserman, Ira; Stack, Steven

    2011-01-01

    Previous work on Russian roulette has focused on data from large cities. It is unclear if the epidemiological patterns based on large cities will replicate for the nation as a whole, and if the influence of minority status will be moderated by urban context. The present investigation fills these gaps by providing descriptive epidemiological data…

  9. Evaluation of Juvenile Salmonid Outmigration and Survival in the Lower Umatilla River Basin, Annual Report 2003-2006.

    White, Tara

    2007-02-01

    This report summarizes activities conducted by the Oregon Department of Fish and Wildlife's Juvenile Outmigration and Survival M&E project in the Umatilla River subbasin between 2004-2006. Information is used to make informed decisions on hatchery effectiveness, natural production success, passage improvement and flow enhancement strategies. Data collected includes annual estimates of smolt abundance, migration timing, and survival, life history characteristics and productivity status and trends for spring and fall Chinook salmon, coho salmon and summer steelhead. Productivity data provided is the key subbasin scale measure of the effectiveness of salmon and steelhead restoration actions in the Umatilla River. Information is also used for regional planning and recovery efforts of Mid-Columbia River (MCR) ESA-listed summer steelhead. Monitoring is conducted via smolt trapping and PIT-tag interrogation at Three Mile Falls Dam. The Umatilla Juvenile Outmigration and Survival Project was established in 1994 to evaluate the success of management actions and fisheries restoration efforts in the Umatilla River Basin. Project objectives for the 2004-2006 period were to: (1) operate the PIT tag detection system at Three Mile Falls Dam (TMFD), (2) enhance provisional PIT-tag interrogation equipment at the east bank adult fish ladder, (3) monitor the migration timing, abundance and survival of naturally-produced juvenile salmonids and trends in natural production, (4) determine migration parameters and survival of hatchery-produced fish representing various rearing, acclimation and release strategies, (5) evaluate the relative survival between transported and non-transported fish, (6) monitor juvenile life history characteristics and evaluate trends over time, (7) investigate the effects of river, canal, fishway operations and environmental conditions on smolt migration and survival, (8) document the temporal distribution and diversity of resident fish species, and (9) participate in planning and coordination activities within the basin and dissemination of results.

  10. Occurrence of organic wastewater-indicator compounds in urban streams of the Atlanta area, Georgia, 2003-2006

    Lawrence, Stephen J.; LaFontaine, Jacob H.

    2010-01-01

    Between March 2003 and January 2006, 863 water samples were collected from streams in seven urban watersheds with varying land uses within or near the City of Atlanta, Georgia. Sixty-four sampling sites representing three site types were established in those watersheds. The first type consisted of sites within three watersheds not affected by combined sewer overflows; these were designated as the control basins. The second and third site types were established in four watersheds and were designated as sites upstream or downstream from combined sewer outfalls.

  11. Characterization of the Kootenai River Aquatic Macroinvertebrate Community before and after Experimental Nutrient Addition, 2003-2006. [Chapter 3

    Holderman, Charlie [Kootenai Tribe of Idaho Bonners

    2009-02-19

    The Kootenai River ecosystem has experienced numerous ecological changes since the early 1900s. Some of the largest impacts to habitat, biological communities, and ecological function resulted from levee construction along the 120 km of river upstream from Kootenay Lake, completed by the 1950s, and the construction and operation of Libby Dam, completed in 1972 on the river near Libby Montana. Levee construction isolated tens of thousands of hectares of historic functioning floodplain habitat from the river channel, eliminating nutrient production and habitat diversity crucial to the functioning of a large river-floodplain ecosystem. Libby Dam continues to create large changes in the timing, duration, and magnitude of river flows, and greatly reduces sediment and nutrient transport to downstream river reaches. These changes have contributed to the ecological collapse of the post-development Kootenai River ecosystem and its native biological communities. In response to this artificial loss of nutrients, experimental nutrient addition was initiated in the Kootenay Lake's North Arm in 1992, the South Arm in 2004, and in the Kootenai River at the Idaho-Montana border during 2005. This report characterizes the macroinvertebrate community in the Kootenai River and its response to experimental nutrient addition during 2005 and 2006. This report also provides an initial evaluation of cascading trophic interactions in response to nutrient addition. Macroinvertebrates were sampled at 12 sites along a 325 km section of the Kootenai River, representing an upriver unimpounded reference reach, treatment and control canyon reach sites, and braided and meandering reach sites, all downstream from Libby Dam. Principle component analysis revealed that richness explained the greatest amount of variability in response to nutrient addition as did taxa from Acari, Coleoptera, Ephemeroptera, Plecoptera, and Trichoptera. Analysis of variance revealed that nutrient addition had a significant effect (p<0.0001) on invertebrate abundance, biomass, and richness at sites KR-9 and KR-9.1 combined (the zone of maximum biological response). Richness, a valuable ecological metric, increased more than abundance and biomass, which were subject to greater sampling bias. Cascading trophic interactions were observed as increased algal accrual, increased in-river invertebrate abundance, and increased invertebrate counts in mountain whitefish (Prosopium williamsonii) guts samples, but were not quantitatively tested. Sampling and analyses across trophic levels are currently ongoing and are expected to better characterize ecological responses to experimental nutrient addition in the Kootenai River.

  12. Monitoreo del glaciar horcones inferior y sus termokarst, antes y durante el surge de 2003-2006: Andes centrales argentinos

    María Gabriela Lenzano

    2012-12-01

    Full Text Available En el presente trabajo se expone el monitoreo de termokarts glaciarios y su relación e interacción con los eventos surges ocurridos en el glaciar cubierto Horcones Inferior (GHI. Este glaciar se encuentra ubicado a los 32º 41'S y 69º 57'W, al pie de la pared sur del C° Aconcagua, Parque Provincial Aconcagua, en la Provincia de Mendoza, Argentina. El estudio fue llevado a cabo a través de la implementación de métodos indirectos de detección utilizando imágenes de los sensores Landsat y Aster durante el período 1997-2006. En el Glaciar Horcones Inferior "GHI", la superficie ocupada por los termokarst alcanza valores que varían entre el 4.3% y el 0% de la superficie total del glaciar, al finalizar un evento de surge. Las velocidades registradas en la superficie del glaciar cubierto arrojaron valores promedios entre 0.4 y 12 m/día. La metodología aplicada, con imágenes satelitales históricas, representa una herramienta fundamental para separar períodos de flujo glaciario catastróficos y no catastróficos.This work analyses the temporal evolution of thermokarst and their relationship to the surges in a reconstituted debris covered glacier. The glacier Horcones Inferior is located at Lat 32º 41' S and Long 69º 57' W in the Provincial Park Aconcagua, Mendoza, Argentina, on the foot of the Aconcagua massif. The study and monitoring of the thermokarst was carried out applying indirect methods using Landsat and Aster images from 1997-2006. Detected percentages of thermokarst, in relation to the total glacial area, showed that they varied between 4.3% to 0% at the end of the surge event. The registered speeds of the glacier -on the glacial surface- reached averages of between 0.4 and 12 m/d. This methodology, with historical images from archives, represents a fundamental tool to separate catastrophic and non-catastrophic glacial flow periods.

  13. Confirmatory Factor Analysis of the WAIS-IV and WMS-IV in Older Adults

    Miller, Delyana I.; Davidson, Patrick S. R.; Schindler, Dwayne; Messier, Claude

    2013-01-01

    New editions of the Wechsler Adult Intelligence and Memory scales are now available. Yet, given the significant changes in these new releases and the skepticism that has met them, independent evidence on their psychometric properties is much needed but currently lacking. We administered the WAIS-IV and the Older Adult version of the WMS-IV to 145…

  14. On the stabilization of niobium(V) solutions by zirconium(IV) and hafnium(IV)

    Sørensen, E.; Bjerre, A.B.

    1992-01-01

    Niobium cannot be separated from zirconium or hafnium when these elements occur together in solution with common anions such as chloride and sulphate. This is ascribed to the co-polymerization of niobium(V) and the hydrolysed ionic species of zirconium(IV) and hafnium(IV) to form colloidal...

  15. Seafloor earthquake measurement system, SEMS IV

    Platzbecker, M.R.; Ehasz, J.P.; Franco, R.J.

    1997-07-01

    Staff of the Telemetry Technology Development Department (2664) have, in support of the U.S. Interior Department Mineral Management Services (MMS), developed and deployed the Seafloor Earthquake Measurement System IV (SEMS IV). The result of this development project is a series of three fully operational seafloor seismic monitor systems located at offshore platforms: Eureka, Grace, and Irene. The instrument probes are embedded from three to seven feet into the seafloor and hardwired to seismic data recorders installed top side at the offshore platforms. The probes and underwater cables were designed to survive the seafloor environment with an operation life of five years. The units have been operational for two years and have produced recordings of several minor earthquakes in that time. Sandia Labs will transfer operation of SEMS IV to MMS contractors in the coming months. 29 figs., 25 tabs.

  16. The Berkeley SETI program - SERENDIP IV instrumentation

    Werthimer, Dan; Bowyer, Stuart; Ng, David; Donnelly, Charles; Cobb, Jeff; Lampton, Michael; Airieau, Sabine

    1997-01-01

    We discuss the hardware design of SERENDIP IV, which will be deployed in early 1997 for a 21-cm sky survey at the National Astronomy and Ionospheric Center's 305-m radio telescope in Arecibo, Puerto Rico. SERENDIP IV is a 167 million channel spectrum analyzer, covering a 100-Mhz bandwidth, with 0.6-Hz resolution and a 1.7-s integration time. SERENDIP IV's modular design incorporates a bank of digital mixers and filters to separate the 100 MHz band into 40 2.5 MHz subbands. Each 2.5 MHz subband is further broken down into 0.6 Hz bins by means of a four million point fast Fourier transform. The resulting power spectra are analyzed by 40 high-speed processors. Narrowband signals having power significantly above background noise levels are recorded along with telescope coordinates, time, and frequency. The data are sent in real time to Berkeley for analysis.

  17. Oxochloroalkoxide of the Cerium (IV and Titanium (IV as oxides precursor

    Machado Luiz Carlos

    2002-01-01

    Full Text Available The Cerium (IV and Titanium (IV oxides mixture (CeO2-3TiO2 was prepared by thermal treatment of the oxochloroisopropoxide of Cerium (IV and Titanium (IV. The chemical route utilizing the Cerium (III chloride alcoholic complex and Titanium (IV isopropoxide is presented. The compound Ce5Ti15Cl16O30 (iOPr4(OH-Et15 was characterized by elemental analysis, FTIR and TG/DTG. The X-ray diffraction patterns of the oxides resulting from the thermal decomposition of the precursor at 1000 degreesC for 36 h indicated the formation of cubic cerianite (a = 5.417Å and tetragonal rutile (a = 4.592Å and (c = 2.962 Å, with apparent crystallite sizes around 38 and 55nm, respectively.

  18. Polityka religijna Ptolemeusza IV Filopatora : wybrane aspekty

    Grabowski, Tomasz

    2014-01-01

    Religion was very highly placed in the politics and propaganda of the Ptolemaic dynasty. Ptolemy IV Philopator belonged to the kings of Egypt who were particularly active in this field. The person of Ptolemy I Soter, who was the founder of the dynasty, was of considerable importance in his policy. Among many other things, Ptolemy IV established his eponymous cult in Ptolemais. He also invested the dynastic cult with its final form by incorporating into it the cult of Theoi Soters (Ptolemy I a...

  19. Dipeptidyl peptidase-IV (DPP-IV inhibitory activity of parotid exudate of Bufo melanostictus

    Allenki Venkatesham

    2009-01-01

    Full Text Available Type 2 diabetes arises as a result of β-cell failure combined with concomitant insulin resistance. Glucagon-like peptide-1 is a gastrointestinal hormone that is released postprandially from the L cells of the gut and exerts a glucose- dependent and direct insulinotropic effect on the pancreatic β cell. Which activate adenylate cyclase and enhances insulin secretion. GLP-1 is rapidly degraded by DPP-IV to GLP-1(9-37 amide following release from gut L cells. GLP-1 directly enhances glucose-dependent insulin secretion via an increase in β-cell cAMP. Dipeptidyl peptidase IV (DPP-IV is a plasma membrane glycoprotein ectopeptidase. In mammals, DPP-IV was widely expressed on the surface of endothelial and epithelial cells and highest levels in humans have been reported to occur in the intestine, bone marrow and kidney. Inhibiting DPP-IV reduces its rapid degradation of GLP-1, increasing circulating levels of the active hormone in vivo and prolonging its beneficial effects. The IC 50 value of parotid exudate was found to be 9.4 μg/ml. The maximum % inhibition (61.8 was showed at a concentration of 12μg/ml. Parotid exudate through inhibition of DPP-IV, improves glucose tolerance and enhances insulin secretion. DPP-IV inhibitors are a novel class of oral hypoglycemic agents with a potential to improve pancreatic beta cell function and the clinical course of type 2 diabetes.

  20. TFRC—IVS Flow Control Algorithm

    HEKaijian; LINYaping; YANGAng

    2003-01-01

    This paper investigates the TCP (Trans-mission Control Protocol) friendliness of multicast video-conferencing systems. Through the analysis and simulation experiments it is shown that the slow response to network state changes and the fixed rate adjustment process lead to TCP unfriendliness in the bandwidth sharing. Therefore,this paper proposes a new TCP friendly flow control al-gorithm called TFRC-IVS flow control algorithm for the current best-effort Internet. TFRC-IVS (TCP-Friendly Rate Control--INRIA Videoconferencing System) algo-rithm utilizes TCP friendly control function derived from complex TCP model to calculate TCP friendly sending rate.Simulation results show that TFRC-IVS flow control algorithm improves the smoothness of transmission rates and converges quickly to the stable sending rate. In addi-tion, the TCP friendly control function in TFRC-IVS flow control algorithm ensures the TCP friendliness of video flows and fair bandwidth allocation with TCP flows, which the traditional static rate adjustment algorithm lacks.

  1. Bis(4-methylpiperidinium hexachloridostannate(IV

    Madeleine Helliwell

    2008-04-01

    Full Text Available The crystal structure of the title compound, (C6H14N2[SnCl6], is built of 4-methylpiperidinium cations, occupying special positions on the mirror plane, and hexachloridostannate(IV anions on a special position of 2/m symmetry. The ions are linked via N—H...Cl hydrogen bonds into chains running along the b axis.

  2. Painlevé IV coherent states

    Bermudez, David, E-mail: david.bermudez@weizmann.ac.il [Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100 (Israel); Departamento de Física, Cinvestav, A.P. 14-740, 07000 México D.F. (Mexico); Contreras-Astorga, Alonso, E-mail: aloncont@iun.edu [Department of Mathematics and Actuarial Science, Indiana University Northwest, 3400 Broadway, Gary IN 46408 (United States); Departamento de Física, Cinvestav, A.P. 14-740, 07000 México D.F. (Mexico); Fernández C, David J., E-mail: david@fis.cinvestav.mx [Departamento de Física, Cinvestav, A.P. 14-740, 07000 México D.F. (Mexico)

    2014-11-15

    A simple way to find solutions of the Painlevé IV equation is by identifying Hamiltonian systems with third-order differential ladder operators. Some of these systems can be obtained by applying supersymmetric quantum mechanics (SUSY QM) to the harmonic oscillator. In this work, we will construct families of coherent states for such subset of SUSY partner Hamiltonians which are connected with the Painlevé IV equation. First, these coherent states are built up as eigenstates of the annihilation operator, then as displaced versions of the extremal states, both involving the related third-order ladder operators, and finally as extremal states which are also displaced but now using the so called linearized ladder operators. To each SUSY partner Hamiltonian corresponds two families of coherent states: one inside the infinite subspace associated with the isospectral part of the spectrum and another one in the finite subspace generated by the states created through the SUSY technique. - Highlights: • We use SUSY QM to obtain Hamiltonians with third-order differential ladder operators. • We show that these systems are related with the Painlevé IV equation. • We apply different definitions of coherent states to these Hamiltonians using the third-order ladder operators and some linearized ones. • We construct families of coherent states for such systems, which we called Painlevé IV coherent states.

  3. Industrial Waste Landfill IV upgrade package

    1994-03-29

    The Y-12 Plant, K-25 Site, and ORNL are managed by DOE`s Operating Contractor (OC), Martin Marietta Energy Systems, Inc. (Energy Systems) for DOE. Operation associated with the facilities by the Operating Contractor and subcontractors, DOE contractors and the DOE Federal Building result in the generation of industrial solid wastes as well as construction/demolition wastes. Due to the waste streams mentioned, the Y-12 Industrial Waste Landfill IV (IWLF-IV) was developed for the disposal of solid industrial waste in accordance to Rule 1200-1-7, Regulations Governing Solid Waste Processing and Disposal in Tennessee. This revised operating document is a part of a request for modification to the existing Y-12 IWLF-IV to comply with revised regulation (Rule Chapters 1200-1-7-.01 through 1200-1-7-.08) in order to provide future disposal space for the ORR, Subcontractors, and the DOE Federal Building. This revised operating manual also reflects approved modifications that have been made over the years since the original landfill permit approval. The drawings referred to in this manual are included in Drawings section of the package. IWLF-IV is a Tennessee Department of Environmental and Conservation/Division of Solid Waste Management (TDEC/DSWM) Class 11 disposal unit.

  4. Gen IV Materials Handbook Implementation Plan

    Rittenhouse, P.; Ren, W.

    2005-03-29

    A Gen IV Materials Handbook is being developed to provide an authoritative single source of highly qualified structural materials information and materials properties data for use in design and analyses of all Generation IV Reactor Systems. The Handbook will be responsive to the needs expressed by all of the principal government, national laboratory, and private company stakeholders of Gen IV Reactor Systems. The Gen IV Materials Handbook Implementation Plan provided here addresses the purpose, rationale, attributes, and benefits of the Handbook and will detail its content, format, quality assurance, applicability, and access. Structural materials, both metallic and ceramic, for all Gen IV reactor types currently supported by the Department of Energy (DOE) will be included in the Gen IV Materials Handbook. However, initial emphasis will be on materials for the Very High Temperature Reactor (VHTR). Descriptive information (e.g., chemical composition and applicable technical specifications and codes) will be provided for each material along with an extensive presentation of mechanical and physical property data including consideration of temperature, irradiation, environment, etc. effects on properties. Access to the Gen IV Materials Handbook will be internet-based with appropriate levels of control. Information and data in the Handbook will be configured to allow search by material classes, specific materials, specific information or property class, specific property, data parameters, and individual data points identified with materials parameters, test conditions, and data source. Details on all of these as well as proposed applicability and consideration of data quality classes are provided in the Implementation Plan. Website development for the Handbook is divided into six phases including (1) detailed product analysis and specification, (2) simulation and design, (3) implementation and testing, (4) product release, (5) project/product evaluation, and (6) product

  5. Annotations on Mexico's WISC-IV: a validity study.

    Fina, Anthony D; Sánchez-Escobedo, Pedro; Hollingworth, Liz

    2012-01-01

    This project seeks to provide evidence on the internal structure of the Escala Wechsler de Inteligencia para Niños-IV (EWIN-IV; Wechsler, 2007a ) through a confirmatory factor analysis and intercorrelational study. Also provided is information on the adaptation process and other sources of validity evidence in support of the EWIN-IV norms. The standardization data for the EWIN-IV were used for all analyses. The factor loadings and correlational patterns found on the EWIN-IV are comparable to those seen in the American versions of the test. The proposed factor and scoring structure of the EWIN-IV was supported.

  6. [Fe IV] Emission in Ionized Nebulae

    M. Rodríguez

    2003-01-01

    Full Text Available Se presentan los resultados de un análisis de la emisión en [Fe IV] en varias nebulosas ionizadas, basado en nuevas identificaciones y medidas anteriores de líneas de [Fe IV]. Las abundancias de Fe obtenidas al sumar las abundancias de los iones relevantes (principalmente Fe++ y Fe3+ resultan ser menores, por factores en el rango 2.6-5.9, que las abundancias implicadas por las líneas de [Fe III] y un factor de corrección por la ionizacion obtenido con modelos de ionizacion. Se discuten las posibles razones de esta discrepancia así como las implicaciones que tiene para nuestro entendimiento tanto de la evolución del polvo en nebulosas ionizadas como de la historia química de galaxias de baja metalicidad.

  7. Fluctuations in type IV pilus retraction

    Linden, M; Jonsson, A B; Wallin, M; Linden, Martin; Johansson, Emil; Jonsson, Ann-Beth; Wallin, Mats

    2005-01-01

    The type IV pilus retraction motor is found in many important bacterial pathogens. It is the strongest known linear motor protein and is required for bacterial infectivity. We characterize the dynamics of type IV pilus retraction in terms of a stochastic chemical reaction model. We find that a two state model can describe the experimental force velocity relation and qualitative dependence of ATP concentration. The results indicate that the dynamics is limited by an ATP-dependent step at low load and a force-dependent step at high load, and that at least one step is effectively irreversible in the measured range of forces. The irreversible nature of the sub-step(s) lead to interesting predictions for future experiments: We find different parameterizations with mathematically identical force velocity relations but different fluctuations (diffusion constant). We also find a longer elementary step compared to an earlier analysis, which agrees better with known facts about the structure of the pilus filament and e...

  8. What Is New in Rome IV

    Schmulson, Max J; Drossman, Douglas A

    2017-01-01

    Functional gastrointestinal disorders (FGIDs) are diagnosed and classified using the Rome criteria; the criteria may change over time as new scientific data emerge. The Rome IV was released in May 2016. The aim is to review the main changes in Rome IV. FGIDs are now called disorders of gut-brain interaction (DGBI). Rome IV has a multicultural rather than a Western-culture focus. There are new chapters including multicultural, age-gender-women’s health, intestinal microenvironment, biopsychosocial, and centrally mediated disorders. New disorders have been included although not truly FGIDs, but fit the new definition of DGBI including opioid-induced gastrointestinal hyperalgesia, opioid-induced constipation, and cannabinoid hyperemesis. Also, new FGIDs based on available evidence including reflux hypersensitivity and centrally mediated abdominal pain syndrome. Using a normative survey to determine the frequency of normal bowel symptoms in the general population changes in the time frame for diagnosis were introduced. For irritable bowel syndrome (IBS) only pain is required and discomfort was eliminated because it is non-specific, having different meanings in different languages. Pain is now related to bowel movements rather than just improving with bowel movements (ie, can get worse with bowel movement). Functional bowel disorders (functional diarrhea, functional constipation, IBS with predominant diarrhea [IBS-D], IBS with predominant constipation [IBS-C], and IBS with mixed bowel habits) are considered to be on a continuum rather than as independent entities. Clinical applications such as diagnostic algorithms and the Multidimensional Clinical Profile have been updated. The new Rome IV iteration is evidence-based, multicultural oriented and with clinical applications. As new evidence become available, future updates are expected. PMID:28274109

  9. Soome-ugri IV maailmakongressi kunstiprogramm

    2004-01-01

    Soome-ugri IV maailmakongressi kultuuriprogrammi raames toimub Sagadis Tiiu Kirsipuu kureeritud puuskulptuuri sümpoosion "Ilmapuu". 8. augustist on soome-ugri kunstnikud Anatoli Stepanov, Nikolai Bõkov, Marja-Liisa Mäki-Penttilä, Jakov Jakovlev, Reino Saijets, Jozsef Lukacs, Anatoli Punegov, Pjotr Rjabov, Elo Liiv ja Urmas Rauba teinud puuskulptuure, mida eksponeeritakse kongressi toimumise ajal Tallinnas. Urmas Sisaski kontsert mõisapargis

  10. Dipyridinium tribromidochloridobis(4-chlorophenylstannate(IV

    Kong Mun Lo

    2009-06-01

    Full Text Available The tin atom in the substituted ammonium stannate(IV, (C5H6N2[SnBr3(C6H4Cl2Cl], lies on a center of symmetry in a distorted octahedral coordination geometry. Each independent halogen site is occupied by bromine and chlorine anions in an approximate 3:1 ratio. The pyridinium cation forms a hydrogen bond to only one of the halogen atoms.

  11. Examining Computational Assumptions For Godiva IV

    Kirkland, Alexander Matthew [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jaegers, Peter James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-11

    Over the course of summer 2016, the effects of several computational modeling assumptions with respect to the Godiva IV reactor were examined. The majority of these assumptions pertained to modeling errors existing in the control rods and burst rod. The Monte Carlo neutron transport code, MCNP, was used to investigate these modeling changes, primarily by comparing them to that of the original input deck specifications.

  12. Generation-IV Nuclear Energy Systems

    McFarlane, Harold

    2008-05-01

    Nuclear power technology has evolved through roughly three generations of system designs: a first generation of prototypes and first-of-a-kind units implemented during the period 1950 to 1970; a second generation of industrial power plants built from 1970 to the turn of the century, most of which are still in operation today; and a third generation of evolutionary advanced reactors which began being built by the turn of the 20^th century, usually called Generation III or III+, which incorporate technical lessons learned through more than 12,000 reactor-years of operation. The Generation IV International Forum (GIF) is a cooperative international endeavor to develop advanced nuclear energy systems in response to the social, environmental and economic requirements of the 21^st century. Six Generation IV systems under development by GIF promise to enhance the future contribution and benefits of nuclear energy. All Generation IV systems aim at performance improvement, new applications of nuclear energy, and/or more sustainable approaches to the management of nuclear materials. High-temperature systems offer the possibility of efficient process heat applications and eventually hydrogen production. Enhanced sustainability is achieved primarily through adoption of a closed fuel cycle with reprocessing and recycling of plutonium, uranium and minor actinides using fast reactors. This approach provides significant reduction in waste generation and uranium resource requirements.

  13. DNA ligase IV syndrome; a review.

    Altmann, Thomas; Gennery, Andrew R

    2016-10-07

    DNA ligase IV deficiency is a rare primary immunodeficiency, LIG4 syndrome, often associated with other systemic features. DNA ligase IV is part of the non-homologous end joining mechanism, required to repair DNA double stranded breaks. Ubiquitously expressed, it is required to prevent mutagenesis and apoptosis, which can result from DNA double strand breakage caused by intracellular events such as DNA replication and meiosis or extracellular events including damage by reactive oxygen species and ionising radiation.Within developing lymphocytes, DNA ligase IV is required to repair programmed DNA double stranded breaks induced during lymphocyte receptor development.Patients with hypomorphic mutations in LIG4 present with a range of phenotypes, from normal to severe combined immunodeficiency. All, however, manifest sensitivity to ionising radiation. Commonly associated features include primordial growth failure with severe microcephaly and a spectrum of learning difficulties, marrow hypoplasia and a predisposition to lymphoid malignancy. Diagnostic investigations include immunophenotyping, and testing for radiosensitivity. Some patients present with microcephaly as a predominant feature, but seemingly normal immunity. Treatment is mainly supportive, although haematopoietic stem cell transplantation has been used in a few cases.

  14. Planning a Kinetic and Mechanistic Study with Cerium (IV)

    Hanna, Samir B.; And Others

    1976-01-01

    Presents a kinetic study that utilizes a method for varying the concentrations of the possible Ce(IV) species and computing the concentration distribution of the sulfato and hydroxo species of Ce(IV). (MLH)

  15. Synthesis and evaluation of artificial antigens for astragaloside IV

    Sheng-lan Yu

    2014-06-01

    Full Text Available The objective of this study was to produce artificial antigens for astragaloside IV that could be used to prepare antibodies against astragaloside IV screened in Radix astragali (Astragalus membranaceus (Fisch Bunge, Fabaceae and its preparations, using an indirect ELISA. Astragaloside IV was coupled to carrier proteins, bovine serum albumin and ovalbumin using the sodium periodate method and was then evaluated using SDS-PAGE, MALDI-TOF MS and animal immunizations. The coupling ratio of astragaloside IV to bovine serum albumin ratio was determined to be thirteen, and the indirect ELISA demonstrated that three groups of mice immunized with astragaloside IV-bovine serum albumin produced anti-astragaloside IV- bovine serum albumin-specific antibody, with a minimum serum titer of 1:9600. A method for synthesizing highly immunogenic astragaloside IV artificial antigens was successfully developed thus indicating its feasibility in the establishment of a fast immunoassay for astragaloside IV content determination in Radix astragali and its products.

  16. Density diagnostics derived from the O iv and S iv intercombination lines observed by IRIS

    Polito, V.; Del Zanna, G.; Dudík, J.; Mason, H. E.; Giunta, A.; Reeves, K. K.

    2016-10-01

    The intensity of the O iv 2s2 2p 2P-2s2p24P and S iv 3 s2 3p 2P-3s 3p24 P intercombination lines around 1400 Å observed with the Interface Region Imaging Spectrograph (IRIS) provide a useful tool to diagnose the electron number density (Ne) in the solar transition region plasma. We measure the electron number density in a variety of solar features observed by IRIS, including an active region (AR) loop, plage and brightening, and the ribbon of the 22-June-2015 M 6.5 class flare. By using the emissivity ratios of O iv and S iv lines, we find that our observations are consistent with the emitting plasma being near isothermal (logT[K] ≈ 5) and iso-density (Ne ≈ 1010.6 cm-3) in the AR loop. Moreover, high electron number densities (Ne ≈ 1013 cm-3) are obtained during the impulsive phase of the flare by using the S iv line ratio. We note that the S iv lines provide a higher range of density sensitivity than the O iv lines. Finally, we investigate the effects of high densities (Ne ≳ 1011 cm-3) on the ionization balance. In particular, the fractional ion abundances are found to be shifted towards lower temperatures for high densities compared to the low density case. We also explored the effects of a non-Maxwellian electron distribution on our diagnostic method. The movie associated to Fig. 3 is available at http://www.aanda.org

  17. 40 CFR 144.23 - Class IV wells.

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Class IV wells. 144.23 Section 144.23... INJECTION CONTROL PROGRAM Authorization of Underground Injection by Rule § 144.23 Class IV wells. (a) Injection into existing Class IV wells is authorized for up to six months after approval or promulgation...

  18. 78 FR 45592 - DeltaPoint Capital IV, LP;

    2013-07-29

    ... ADMINISTRATION DeltaPoint Capital IV, LP; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that DeltaPoint Capital IV, L.P., 45 East Avenue... Business Administration (``SBA'') Rules and Regulations (13 CFR 107.730). DeltaPoint Capital IV,...

  19. 29 CFR 4022.63 - Estimated title IV benefit.

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Estimated title IV benefit. 4022.63 Section 4022.63 Labor... PAYABLE IN TERMINATED SINGLE-EMPLOYER PLANS Benefit Reductions in Terminating Plans § 4022.63 Estimated... administrator shall determine each participant's estimated title IV benefit. The estimated title IV...

  20. Surgical decision making for stage IV adult acquired flatfoot disorder.

    Peterson, Kyle S; Hyer, Christopher F

    2014-07-01

    Adult acquired flatfoot deformity is a debilitating musculoskeletal condition affecting the lower extremity. Posterior tibial tendon dysfunction (PTTD) is the primary etiology for the development of a flatfoot deformity in an adult. PTTD is classified into 4 stages (with stage IV subdivided into stage IV-A and IV-B). This classification is described in detail in this article.

  1. Expanding the Ecological Validity of WAIS-IV and WMS-IV With the Texas Functional Living Scale

    Drozdick, Lisa Whipple; Cullum, C. Munro

    2010-01-01

    Assessment of functional status is an important aspect of clinical evaluation. As part of the standardization of the Wechsler Adult Intelligence Scale–Fourth Edition (WAIS-IV) and Wechsler Memory Scale–Fourth Edition (WMS-IV), participants completed the Texas Functional Living Scale (TFLS), a measure of Instrumental Activities of Daily Living. The relationships between TFLS and WAIS-IV and WMS-IV were examined in both normally developing and clinical samples. In general, the highest correlati...

  2. De Medische Paragraaf bij de GBL is gereed. Een kort overzicht van de inhoud

    Wilken, A.; Akkermans, A.J.

    2012-01-01

    Op 15 december 2011 is de Medische Paragraaf bij de Gedragscode Behandeling Letselschade (GBL) aanvaard door het platform van De Letselschade Raad. De Medische Paragraaf bestaat uit vijf onderdelen die aansluiten bij het globale chronologische verloop van het medisch beoordelingstraject. Hij treedt

  3. Revisiting Case IV: a reassessment of bias and standard errors of Case IV under range restriction.

    Fife, Dustin A; Mendoza, Jorge L; Terry, Robert

    2013-11-01

    In 2004, Hunter and Schmidt proposed a correction (called Case IV) that seeks to estimate disattenuated correlations when selection is made on an unmeasured variable. Although Case IV is an important theoretical development in the range restriction literature, it makes an untestable assumption, namely that the partial correlation between the unobserved selection variable and the performance measure is zero. We show in this paper why this assumption may be difficult to meet and why previous simulations have failed to detect the full extent of bias. We use meta-analytic literature to investigate the plausible range of bias. We also show how Case IV performs in terms of standard errors. Finally, we give practical recommendations about how the contributions of Hunter and Schmidt (2004) can be extended without making such stringent assumptions.

  4. Topological characterisation and identification of critical domains within glucosyltransferase IV (GtrIV of Shigella flexneri

    Nair Anesh

    2011-12-01

    Full Text Available Abstract Background The three bacteriophage genes gtrA, gtrB and gtr(type are responsible for O-antigen glucosylation in Shigella flexneri. Both gtrA and gtrB have been demonstrated to be highly conserved and interchangeable among serotypes while gtr(type was found to be specific to each serotype, leading to the hypothesis that the Gtr(type proteins are responsible for attaching glucosyl groups to the O-antigen in a site- and serotype- specific manner. Based on the confirmed topologies of GtrI, GtrII and GtrV, such interaction and attachment of the glucosyl groups to the O-antigen has been postulated to occur in the periplasm. Results In this study, the topology of GtrIV was experimentally determined by creating different fusions between GtrIV and a dual-reporter protein, PhoA/LacZ. This study shows that GtrIV consists of 8 transmembrane helices, 2 large periplasmic loops, 2 small cytoplasmic N- and C- terminal ends and a re-entrant loop that occurs between transmembrane helices III and IV. Though this topology differs from that of GtrI, GtrII, GtrV and GtrX, it is very similar to that of GtrIc. Furthermore, both the N-terminal periplasmic and the C-terminal periplasmic loops are important for GtrIV function as shown via a series of loop deletion experiments and the creation of chimeric proteins between GtrIV and its closest structural homologue, GtrIc. Conclusion The current study provides the basis for elucidating the structure and mechanism of action of this important O-antigen modifying glucosyltransferase.

  5. New Materials for NGNP/Gen IV

    Robert W. Swindeman; Douglas L. Marriott

    2009-12-18

    The bounding conditions were briefly summarized for the Next Generation Nuclear Plant (NGNP) that is the leading candidate in the Department of Energy Generation IV reactor program. Metallic materials essential to the successful development and proof of concept for the NGNP were identified. The literature bearing on the materials technology for high-temperature gas-cooled reactors was reviewed with emphasis on the needs identified for the NGNP. Several materials were identified for a more thorough study of their databases and behavioral features relative to the requirements ASME Boiler and Pressure Vessel Code, Section III, Division 1, Subsection NH.

  6. Research in collegiate mathematics education IV

    Dubinsky, Ed; Kaput, Jim

    2001-01-01

    This fourth volume of Research in Collegiate Mathematics Education (RCME IV) reflects the themes of student learning and calculus. Included are overviews of calculus reform in France and in the U.S. and large-scale and small-scale longitudinal comparisons of students enrolled in first-year reform courses and in traditional courses. The work continues with detailed studies relating students' understanding of calculus and associated topics. Direct focus is then placed on instruction and student comprehension of courses other than calculus, namely abstract algebra and number theory. The volume co

  7. Gen IV Materials Handbook Functionalities and Operation

    Ren, Weiju [ORNL

    2009-12-01

    This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

  8. Stable kagome lattices from group IV elements

    Leenaerts, O.; Schoeters, B.; Partoens, B.

    2015-03-01

    A thorough investigation of three-dimensional kagome lattices of group IV elements is performed with first-principles calculations. The investigated kagome lattices of silicon and germanium are found to be of similar stability as the recently proposed carbon kagome lattice. Carbon and silicon kagome lattices are both direct-gap semiconductors but they have qualitatively different electronic band structures. While direct optical transitions between the valence and conduction bands are allowed in the carbon case, no such transitions can be observed for silicon. The kagome lattice of germanium exhibits semimetallic behavior but can be transformed into a semiconductor after compression.

  9. Dual (type IV left anterior descending artery

    Ozdil Baskan

    2013-11-01

    Full Text Available Congenital coronary artery anomalies are uncommon. Dual left anterior descending coronary artery (LAD is defined as the presence of two LADs within the anterior interventricular sulcus (AIVS, and is classified into four types. Type IV is a rarely reported subtype and differs from the others, with a long LAD originating from the right coronary artery (RCA. Dual LAD is a benign coronary artery anomaly, but should be recognised especially before interventional procedures. With the increasing use of multidedector computed tomography (MDCT, it is essential for radiologists to be aware of this entity and the cross-sectional findings.

  10. Benzylchloridobis(quinolin-8-olatotin(IV

    Qibao Wang

    2009-08-01

    Full Text Available In the title compound, [Sn(C7H7(C9H6NO2Cl], the SnIV ion is in a distorted octahedral coordination environment formed by the O and N atoms of two bis-chelating quinolin-8-olate ligands, a Cl atom and a C atom from a benzyl ligand. The axial sites are occupied by an N atom of a quinolinate ligand and the C atom of the benzyl ligand. The axial Sn—N bond is slightly shorter than the equatorial Sn—N bond.

  11. Predicting DPP-IV inhibitors with machine learning approaches

    Cai, Jie; Li, Chanjuan; Liu, Zhihong; Du, Jiewen; Ye, Jiming; Gu, Qiong; Xu, Jun

    2017-02-01

    Dipeptidyl peptidase IV (DPP-IV) is a promising Type 2 diabetes mellitus (T2DM) drug target. DPP-IV inhibitors prolong the action of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP), improve glucose homeostasis without weight gain, edema, and hypoglycemia. However, the marketed DPP-IV inhibitors have adverse effects such as nasopharyngitis, headache, nausea, hypersensitivity, skin reactions and pancreatitis. Therefore, it is still expected for novel DPP-IV inhibitors with minimal adverse effects. The scaffolds of existing DPP-IV inhibitors are structurally diversified. This makes it difficult to build virtual screening models based upon the known DPP-IV inhibitor libraries using conventional QSAR approaches. In this paper, we report a new strategy to predict DPP-IV inhibitors with machine learning approaches involving naïve Bayesian (NB) and recursive partitioning (RP) methods. We built 247 machine learning models based on 1307 known DPP-IV inhibitors with optimized molecular properties and topological fingerprints as descriptors. The overall predictive accuracies of the optimized models were greater than 80%. An external test set, composed of 65 recently reported compounds, was employed to validate the optimized models. The results demonstrated that both NB and RP models have a good predictive ability based on different combinations of descriptors. Twenty "good" and twenty "bad" structural fragments for DPP-IV inhibitors can also be derived from these models for inspiring the new DPP-IV inhibitor scaffold design.

  12. Correcting C IV-based virial black hole masses

    Coatman, Liam; Hewett, Paul C.; Banerji, Manda; Richards, Gordon T.; Hennawi, Joseph F.; Prochaska, J. Xavier

    2017-02-01

    The C IVλλ1498,1501 broad emission line is visible in optical spectra to redshifts exceeding z ˜ 5. C IV has long been known to exhibit significant displacements to the blue and these `blueshifts' almost certainly signal the presence of strong outflows. As a consequence, single-epoch virial black hole (BH) mass estimates derived from C IV velocity widths are known to be systematically biased compared to masses from the hydrogen Balmer lines. Using a large sample of 230 high-luminosity (LBol = 1045.5-1048 erg s-1), redshift 1.5 < z < 4.0 quasars with both C IV and Balmer line spectra, we have quantified the bias in C IV BH masses as a function of the C IV blueshift. C IV BH masses are shown to be a factor of 5 larger than the corresponding Balmer-line masses at C IV blueshifts of 3000 km s-1and are overestimated by almost an order of magnitude at the most extreme blueshifts, ≳5000 km s-1. Using the monotonically increasing relationship between the C IV blueshift and the mass ratio BH(C IV)/BH(Hα), we derive an empirical correction to all C IV BH masses. The scatter between the corrected C IV masses and the Balmer masses is 0.24 dex at low C IV blueshifts (˜0 km s-1) and just 0.10 dex at high blueshifts (˜3000 km s-1), compared to 0.40 dex before the correction. The correction depends only on the C IV line properties - i.e. full width at half-maximum and blueshift - and can therefore be applied to all quasars where C IV emission line properties have been measured, enabling the derivation of unbiased virial BH-mass estimates for the majority of high-luminosity, high-redshift, spectroscopically confirmed quasars in the literature.

  13. Synthesis and characterization of thorium(IV) and uranium(IV) corrole complexes.

    Ward, Ashleigh L; Buckley, Heather L; Lukens, Wayne W; Arnold, John

    2013-09-18

    The first examples of actinide complexes incorporating corrole ligands are presented. Thorium(IV) and uranium(IV) macrocycles of Mes2(p-OMePh)corrole were synthesized via salt metathesis with the corresponding lithium corrole in remarkably high yields (93% and 83%, respectively). Characterization by single-crystal X-ray diffraction revealed both complexes to be dimeric, having two metal centers bridged via bis(μ-chlorido) linkages. In each case, the corrole ring showed a large distortion from planarity, with the Th(IV) and U(IV) ions residing unusually far (1.403 and 1.330 Å, respectively) from the N4 plane of the ligand. (1)H NMR spectroscopy of both the Th and U dimers revealed dynamic solution behavior. In the case of the diamagnetic thorium corrole, variable-temperature, DOSY (diffusion-ordered) and EXSY (exhange) (1)H NMR spectroscopy was employed and supported that this behavior was due to an intrinsic pseudorotational mode of the corrole ring about the M-M axis. Additionally, the electronic structure of the actinide corroles was assessed using UV-vis spectroscopy, cyclic voltammetry, and variable-temperature magnetic susceptibility. This novel class of macrocyclic complexes provides a rich platform in an underdeveloped area for the study of nonaqueous actinide bonding and reactivity.

  14. The Design of the IGE Evaluation Project Phase IV Comparative Studies. Comparative Study of Phase IV IGE Evaluation Project. Phase IV, Project Paper 80-2.

    Romberg, Thomas A.; And Others

    This paper outlines the design of two Comparative Studies of Phase IV of the Individually Guided Education (IGE) Evaluation Project. More than 2,000 elementary schools in 25 states use the IGE system. The Evaluation Project was designed to gain a comprehensive view of the system's operation and effectiveness. Phase IV investigated pupil outcomes,…

  15. Carpentier, la otra novela (cap. IV

    Urbano Martínez Carmenate

    2014-06-01

    Full Text Available El presente ensayo está extraído de la obra inédita de Urbano Martínez Carmenate, Carpentier, la otra novela (cap. IV. Ofrece una mirada sobre los primeros años de la trayectoria profesional de Alejo Carpentier. Se muestra cómo, durante la década de 1920, se inicia como periodista y cronista teatral. A la vez, comienzan sus conexiones con el Grupo Minorista, que desempeña un papel destacado en la etapa republicana en Cuba. También se contempla su viaje a México en 1926, que constituye su primer contacto directo con la naturaleza y la cultura americanas.

  16. Carpentier, la otra novela (cap. IV

    Urbano Martínez Carmenate

    2014-07-01

    Full Text Available El presente ensayo está extraído de la obra inédita de Urbano Martínez Carmenate, Carpentier, la otra novela (cap. IV. Ofrece una mirada sobre los primeros años de la trayectoria profesional de Alejo Carpentier. Se muestra cómo, durante la década de 1920, se inicia como periodista y cronista teatral. A la vez, comienzan sus conexiones con el Grupo Minorista, que desempeña un papel destacado en la etapa republicana en Cuba. También se contempla su viaje a México en 1926, que constituye su primer contacto directo con la naturaleza y la cultura americanas.

  17. [Vaughan Williams class IV antiarrhythmic drugs].

    Horie, M; Washizuka, T; Ikeguchi, S; Sasayama, S

    1996-08-01

    Vaughan Williams class IV antiarrhythmic drugs have Ca-channel blocking actions. Since L-type Ca-channels play key roles in regulating pulse conduction in atrioventricular node as well as in pathologically-depolarized myocardium, Ca-channel blockers known to modulate this type of Ca-channel (ICa,L) are used as antiarrhythmic agents. ICa,L channels have relatively high threshold potential (-40 mV) to activate and long-opening properties, and are enhanced by beta-adrenergic stimulation. Among three major ICa,L blockers, dihydropyridines such as nifedipine were found to bind to the channel from extracellular side. In contrast, verapamil and diltiazem interact with the channel from the cytoplasmic side, thereby causing rate-dependent block of ICa,L channels. This sideness of pharmacological action of the Ca-channel blockers determines an important therapeutic modality and their indication for tachyarrhythmias.

  18. New mono-organotin (IV) dithiocarbamate complexes

    Muthalib, Amirah Faizah Abdul; Baba, Ibrahim

    2014-09-01

    Eighteen new mono-organotin dithiocarbamate compounds derived each nine from methyltin(IV) and phenyltin(IV) reacted using in-situ method with various type of N-dialkylamine together with carbon disulphide with the ratio of 1:3:3. Elemental and gravimetric analysis showed that the general formula of these compounds were RSnCl[S2CNR'R″]2 (R= Ph, CH3, R' = CH3, C2H5, C7H7 and R″ = C2H5, C6H11, iC3H7, C7H7). These compounds had been characterized by infrared spectroscopy, ultraviolet spectroscopy, 1H, 13C NMR spectroscopy and single crystal X-ray crystallography. The infrared spectra of these compounds showed three important peaks indicating the formation of dithiocarbamate compounds, ν(CN), ν(CS) and ν(Sn-S) band which present in the region of 1444-1519, 954-1098 and 318-349 cm-1 respectively. The ultraviolet-visible spectra showed an absorption band for the π - π* transition of NCS group in the range of 253 - 259 nm due to the intramolecular charge transfer of the ligand. The 13C NMR spectra showed an important shift for δ(N13CS2) in the range of 196.8 - 201.9 ppm.. Single crystal X-ray diffraction studies showed three new structures with the general formula of PhSnCl[S2CN(Et)(i-Pr)]2, MeSnCl[S2CN(Me)(Cy)]2 and MeSnCl[S2CN(i-Pr)(CH2Ph)]2. All structures having a distorted octahedral geometry set by CClS4 donor atom from the two chelating dithiocarbamate ligands.

  19. Attachment of cells to basement membrane collagen type IV

    1986-01-01

    Of ten different cell lines examined, three showed distinct attachment and spreading on collagen IV substrates, and neither attachment nor spreading was enhanced by adding soluble laminin or fibronectin. This reaction was not inhibited by cycloheximide or antibodies to laminin, indicating a direct attachment to collagen IV without the need of mediator proteins. Cell-binding sites were localized to the major triple-helical domain of collagen IV and required an intact triple helical conformatio...

  20. Collagen IV in normal skin and in pathological processes

    Ana Maria Abreu-Velez

    2012-01-01

    Full Text Available Context: Type IV collagen is a type of collagen found primarily in the skin within the basement membrane zone. The type IV collagen C4 domain at the C-terminus is not removed in post-translational processing, and the fibers are thus link head-to-head, rather than in a parallel fashion. Also, type IV collagen lacks a glycine in every third amino-acid residue necessary for the tight collagen helix. Thus, the overall collagen-IV conformation is structurally more pliable and kinked, relative to other collagen subtypes. These structural features allow collagen IV to form sheets, which is the primary structural form found in the cutaneous basal lamina. There are six human genes associated with collagen IV, specifically COL4A1, COL4A2, COL4A3, COL4A4, COL4A5 and COL4A6. The aim of this review is to highlight the significance of this protein in normal skin, and in selected diseases. Results: The alpha 3 protein constituent of type IV collagen is thought to be the antigen implicated in Goodpasture′s syndrome, wherein the immune system attacks the basement membranes of the renal glomeruli and pulmonary alveoli. In addition, mutations to the genes coding for type IV collagen lead to the Alport syndrome. Furthermore, autoantibodies directed against denatured human type IV collagen have been described in rheumatoid arthritis, scleroderma, and SLE. Structural studies of collagen IV have been utilized to differentiate between subepidermal blistering diseases, including bullous pemphigoid, acquired epidermolysis bullosa, anti-epiligrin cicatricial pemphigoid, and bullous lupus erythematosus. Collagen IV is also of importance in wound healing and in embryogenesis. Conclusions: Pathological studies have demonstrated that minor structural differences in collagen IV can lead to distinct, clinically different diseases.

  1. BALTICA IV. Plant maintenance for managing life and performance

    Hietanen, S.; Auerkari, P. [eds.] [VTT Manufacturing Technology, Espoo (Finland). Operational Reliability

    1998-12-31

    BALTICA IV International Conference on Plant Maintenance Managing Life and performance held on September 7-9, 1998 on board M/S Silja Symphony on its cruise between Helsinki-Stockholm and at Aavaranta in Kirkkonummi. The BALTICA IV conference provides a forum for the transfer of technology from applied research to practice. This is one of the two volumes of the proceedings of the BALTICA IV International Conference on Plant Maintenance Managing Life and Performance. The BALTICA IV conference focuses on new technology, recent experience and applications of condition and life management, and on improvements in maintenance strategies for safe and economical operation of power plants. (orig.)

  2. IV therapy and infection control in patients in the community.

    Higginson, Ray

    Universal precautions and general infection control measures need to be considered when undertaking any clinical procedure, but when administering intravenous (IV) therapy (medicines and/or maintenance fluids), specific measures need to be considered. This is especially important for vulnerable patients or if administering IV therapy in the home environment. There are many reasons why patients may need to receive IV therapy in the community, and these will all present nurses with specific problems. This article discusses some of the infection control procedures one must undertake when administering IV therapy to patients in the community.

  3. DNA Ligase IV regulates XRCC4 nuclear localization.

    Francis, Dailia B; Kozlov, Mikhail; Chavez, Jose; Chu, Jennifer; Malu, Shruti; Hanna, Mary; Cortes, Patricia

    2014-09-01

    DNA Ligase IV, along with its interacting partner XRCC4, are essential for repairing DNA double strand breaks by non-homologous end joining (NHEJ). Together, they complete the final ligation step resolving the DNA break. Ligase IV is regulated by XRCC4 and XLF. However, the mechanism(s) by which Ligase IV control the NHEJ reaction and other NHEJ factor(s) remains poorly characterized. Here, we show that a C-terminal region of Ligase IV (aa 620-800), which encompasses a NLS, the BRCT I, and the XRCC4 interacting region (XIR), is essential for nuclear localization of its co-factor XRCC4. In Ligase IV deficient cells, XRCC4 showed deregulated localization remaining in the cytosol even after induction of DNA double strand breaks. DNA Ligase IV was also required for efficient localization of XLF into the nucleus. Additionally, human fibroblasts that harbor hypomorphic mutations within the Ligase IV gene displayed decreased levels of XRCC4 protein, implicating that DNA Ligase IV is also regulating XRCC4 stability. Our results provide evidence for a role of DNA Ligase IV in controlling the cellular localization and protein levels of XRCC4.

  4. Type IV collagen-degrading enzyme activity in human serum.

    Hashimoto,Noriaki

    1988-02-01

    Full Text Available Type IV collagen-degrading enzyme activity was detected in human serum. Serum was preincubated with 4-aminophenylmercuric acetate and trypsin to activate the enzyme prior to assay. Type IV collagen, purified from human placentas and radiolabeled with [1-14C] acetic anhydride, was used as the substrate. The enzyme activity was measured at pH 7.5 and inhibited by treatment with ethylenediaminetetraacetic acid or heat. The assay of type IV collagen-degrading enzyme in human serum might be useful for estimating the degradation of type IV collagen.

  5. Evaluation conjointe de la WAIS-IV et de la MEM-IV

    Paumier, Delphine

    2016-01-01

    L’intelligence et la mémoire, composantes essentielles du fonctionnement cognitif, sont régulièrement évaluées lors d’un bilan psychologique. Chez l’adulte, l’intelligence s’évalue avec la WAIS-IV et la mémoire avec la MEM-IV. Dans notre étude, nous avons évalué conjointement ces batteries en administrant leurs sous-tests principaux à 66 personnes âgées de 18 à 50 ans. Comme ces échelles s’interprètent selon des indices distincts, nous proposons d’utiliser le modèle CHC comme grille de lectur...

  6. A classification system for O-B2 stars based on the Si IV and C IV resonance lines

    Henize, K. G.; Wray, J. D.; Parsons, S. B.

    1981-01-01

    Low-dispersion ultraviolet spectra from Skylab Experiment S-019 are used to explore the variations of Si IV and C IV line strengths with temperature and luminosity. These considerations lead to a classification system in which the Si/C ratio is used to discriminate luminosity among the O stars and temperature among the O9-B2 stars of lower luminosity. Stars falling in these two regimes may be distinguished either by the presence of C IV emission or on the basis of C IV absorption strength. The log(Si IV/C IV) vs C IV diagram is proposed as a primary tool in such a classification system. The rapid variation in the Si IV/C IV ratio from less than 1/10 at O9 to greater than 10 at B1.5 for luminosity class III-V stars appears to be an especially useful criterion for the temperature classification of stars in this spectral range.

  7. New mono-organotin (IV) dithiocarbamate complexes

    Muthalib, Amirah Faizah Abdul; Baba, Ibrahim [School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi (Malaysia)

    2014-09-03

    Eighteen new mono-organotin dithiocarbamate compounds derived each nine from methyltin(IV) and phenyltin(IV) reacted using in-situ method with various type of N-dialkylamine together with carbon disulphide with the ratio of 1:3:3. Elemental and gravimetric analysis showed that the general formula of these compounds were RSnCl[S{sub 2}CNR′R″]{sub 2} (R= Ph, CH{sub 3}, R′ = CH{sub 3}, C{sub 2}H{sub 5}, C{sub 7}H{sub 7} and R″ = C{sub 2}H{sub 5}, C{sub 6}H{sub 11}, iC{sub 3}H{sub 7}, C{sub 7}H{sub 7}). These compounds had been characterized by infrared spectroscopy, ultraviolet spectroscopy, {sup 1}H, {sup 13}C NMR spectroscopy and single crystal X-ray crystallography. The infrared spectra of these compounds showed three important peaks indicating the formation of dithiocarbamate compounds, ν(CN), ν(CS) and ν(Sn-S) band which present in the region of 1444–1519, 954–1098 and 318–349 cm{sup −1} respectively. The ultraviolet-visible spectra showed an absorption band for the π - π* transition of NCS group in the range of 253 – 259 nm due to the intramolecular charge transfer of the ligand. The {sup 13}C NMR spectra showed an important shift for δ(N{sup 13}CS{sub 2}) in the range of 196.8 – 201.9 ppm.. Single crystal X-ray diffraction studies showed three new structures with the general formula of PhSnCl[S{sub 2}CN(Et)(i−Pr)]{sub 2}, MeSnCl[S{sub 2}CN(Me)(Cy)]{sub 2} and MeSnCl[S{sub 2}CN(i−Pr)(CH{sub 2}Ph)]{sub 2}. All structures having a distorted octahedral geometry set by CClS{sub 4} donor atom from the two

  8. Quantitative neuroimaging in mucolipidosis type IV.

    Schiffmann, Raphael; Mayfield, Joan; Swift, Caren; Nestrasil, Igor

    2014-02-01

    Mucolipidosis type IV (MLIV) is an autosomal recessive disorder resulting from mutations in the MCOLN1 gene. This gene encodes the endosomal/lysosomal transient receptor potential channel protein mucolipin-1 (TRPML1). Affected patients suffer from neurodevelopmental abnormalities and progressive retinal dystrophy. In a prospective natural history study we hypothesized the presence of an additional slow cerebral neurodegenerative process. We have recruited 5 patients, tested their neurodevelopmental status, and measured cerebral regional volumes and white matter integrity using MRI yearly. Over a period of up to 3 years, MLIV patients remained neurologically stable. There was a trend for increased cortical and subcortical gray matter volumes and increased ventricular size, while white matter and cerebellar volumes decreased. Mean diffusivity (MD) was increased and fractional anisotropy (FA) values were below normal in all analyzed brain regions. There was a positive correlation between motor scores of the Vineland Scale and the FA values in the corticospinal tract (corr coef 0.39), and a negative correlation with the MD values (corr coef -0.50) in the same brain region. We conclude from these initial findings that deficiency in mucolipin-1 affects the entire brain but that there might be a selective regional cerebral neurodegenerative process in MLIV. In addition, these data suggest that diffusion-weighted imaging might be a good biomarker for following patients with MLIV. Therefore, our findings may be helpful for designing future clinical trials.

  9. FORTRAN IV Digital Filter Design Programs. Digital Systems Education Project.

    Reuss, E.; And Others

    The goals of the Digital Systems Education Project (DISE) include the development and distribution of educational/instructional materials in the digital systems area. Toward that end, this document contains three reports: (1) A FORTRAN IV Design Program for Low-Pass Butterworth and Chebychev Digital Filters; (2) A FORTRAN IV Design Program for…

  10. On the ion chromatographic determination of S(IV)

    Dasgupta, Purnendu K.

    Ion Chromatographie determination of S(IV) is described with special reference to the determination of SO 2(g) and/or aerosol S(IV) along with chloride, nitrate and sulfate in particulate matter. A method is presented for the baseline separation of the above species. The Chromatographic behavior of hydroxymethanesulfonate under various eluent conditions is discussed.

  11. Beyond the DSM-IV: Assumptions, Alternatives, and Alterations

    Lopez, Shane J.; Edwards, Lisa M.; Pedrotti, Jennifer Teramoto; Prosser, Ellie C.; LaRue, Stephanie; Spalitto, Susan Vehige; Ulven, Jon C.

    2006-01-01

    Current diagnostic processes reflect the limitations and utility of the framework of the "Diagnostic and Statistical Manual of Mental Disorders" (4th ed.; DSM-IV; American Psychiatric Association, 1994). Clinical information in the DSM-IV's 5-axis system almost exclusively focuses on weaknesses and pathology and is summarized in a flawed…

  12. CDDIS Data Center Summary for the IVS 2012 Annual Report

    Noll, Carey

    2013-01-01

    This report summarizes activities during 2012 and future plans of the Crustal Dynamics Data Information System (CDDIS) with respect to the International VLBI Service for Geodesy and Astrometry (IVS). Included in this report are background information about the CDDIS, the computer architecture, staff supporting the system, archive contents, and future plans for the CDDIS within the IVS.

  13. Expanding the Ecological Validity of WAIS-IV and WMS-IV with the Texas Functional Living Scale

    Drozdick, Lisa Whipple; Cullum, C. Munro

    2011-01-01

    Assessment of functional status is an important aspect of clinical evaluation. As part of the standardization of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) and Wechsler Memory Scale-Fourth Edition (WMS-IV), participants completed the Texas Functional Living Scale (TFLS), a measure of Instrumental Activities of Daily Living. The…

  14. Actinide Corroles: Synthesis and Characterization of Thorium(IV) and Uranium(IV) bis(-chloride) Dimers

    Ward, Ashleigh L.; Buckley, Heather L.; Gryko, Daniel T.; Lukens, Wayne W.; Arnold, John

    2013-12-01

    The first synthesis and structural characterization of actinide corroles is presented. Thorium(IV) and uranium(IV) macrocycles of Mes2(p-OMePh)corrole were synthesised and characterized by single-crystal X-ray diffraction, UV-Visible spectroscopy, variable-temperature 1H NMR, ESI mass spectrometry and cyclic voltammetry.

  15. Comparative distribution of the alpha 1(IV), alpha 5(IV), and alpha 6(IV) collagen chains in normal human adult and fetal tissues and in kidneys from X-linked Alport syndrome patients.

    Peissel, B; Geng, L.; Kalluri, R.; Kashtan, C; Rennke, H G; Gallo, G R; Yoshioka, K.; Sun, M J; Hudson, B.G.; Neilson, E. G.

    1995-01-01

    We have shown previously that the 5' ends of the genes for the alpha 5(IV) and alpha 6(IV) collagen chains lie head-to-head on Xq22 and are deleted in patients with Alport syndrome (AS)-associated diffuse leiomyomatosis. In this study, we raised a rabbit anti-human alpha 6(IV)chain antibody, demonstrated its specificity by the analysis of recombinant NC1 domains af all six type IV chains, and studied the distribution of the alpha 6(IV) chain in relation to the alpha 1(IV) and alpha 5(IV) chai...

  16. Group IV photonics for the mid infrared

    Soref, Richard

    2013-02-01

    This paper outlines the challenges and benefits of applying silicon-based photonic techniques in the 2 to 5 μm midinfrared (MIR) wavelength range for chem.-bio-physical sensing, medical diagnostics, industrial process control, environmental monitoring, secure communications, Ladar, active imaging, and high-speed communications at 2 μm. Onchip passive and active components, mostly waveguided, will enable opto-electronic CMOS or BiCMOS integrated "circuits" for system-on-a-chip applications such as spectroscopy and lab-on-a-chip. Volume manufacture in a silicon foundry is expected to yield low-cost (or even disposable) chips with benefits in size-weight-power and ruggedness. This is "long-wavelength optoelectronic integration on silicon" which we call LIOS. Room temperature operation appears feasible, albeit with performance compromises at 4 to 5 μm. In addition to the electronics layer (which may include RF wireless), a 3-D LIOS chip can include several inter-communicating layers utilizing the photonic, plasmonic, photoniccrystal and opto-electro-mechanical technologies. The LIOS challenge can be met by (1) discovering new physics, (2) employing "new" IV and III-V alloys, (3) scaling-up and modifying telecom components, and (4) applying nonlinearoptical wavelength conversion in some cases. This paper presents proposals for MIR chip spectrometers employing frequency-comb and Ge blackbody sources. Active heterostructures employing Si, Ge, SiGe, GeSn and SiGeSn are key for laser diodes, photodetectors, LEDs, switches, amplifiers, and modulators that provide totally monolithic foundry integration, while numerous III-V semiconductor MIR devices within the InGaAsSb and InGaAsP families offer practical hybrid integration on Si PICs. Interband cascade and quantum cascade lasers on Ge waveguides are important in this context.

  17. Intermetallic communication in titanium(IV) ferrocenyldiketonates.

    Dulatas, Lea T; Brown, Seth N; Ojomo, Edema; Noll, Bruce C; Cavo, Matthew J; Holt, Paul B; Wopperer, Matthew M

    2009-11-16

    A tetradentate bis(ferrocenyldiketonate) ligand, Fc(2)BobH(2), is prepared via Claisen condensation of acetylferrocene and 2,2'-biphenyldiacetyl chloride, and is metalated with titanium(IV) isopropoxide to give (Fc(2)Bob)Ti(O(i)Pr)(2) in good yield. The isopropoxide groups are replaced with di(4-nitrophenyl)phosphate groups on treatment with the corresponding acid, and with chlorides on treatment with trimethylsilyl chloride. Metathesis with catechol leads to the bis(o-hydroxyphenoxide) complex rather than the chelating catecholate complex. Hydrolysis selectively gives the mu-oxo trimer (Delta,Delta,Delta)/(Lambda,Lambda,Lambda)-{(Fc(2)Bob)Ti(mu-O)}(3). The solid-state structures of the mu-oxo trimer and the bis(o-hydroxyphenoxide) complex show that the ferrocene substituents are oriented proximal to the biphenyl backbone rather than pointed out toward the exogenous groups. The complexes show dramatic changes in color depending on the bound anions, ranging from the red isopropoxide (lambda(max) = 489 nm) to the green bis(di(4-nitrophenyl)phosphate) (lambda(max) = 653 nm). The oxidation potentials of the ferrocenes show modest shifts based on the titanium environment, but the redox potentials of the two ferrocenes are never separated by more than 60 mV. These results and those of density-functional theory (DFT) calculations indicate that the titanium interacts principally with the lowest unoccupied molecular orbital (LUMO) of the ferrocenyldiketonate and very little with its highest occupied molecular orbital (HOMO).

  18. Search for alpha variation in UVES spectra: Analysis of C IV and Si IV doublets towards QSO 1101-264

    Martínez Fiorenzano, A. F.; Vladilo, G.; Bonifacio, P.

    Motivated by previous studies of QSO spectra that reported a variation of the fine structure constant alpha , a search for C IV and Si IV doublets was conducted in the absorption spectrum toward QSO 1101-264, obtained by VLT-UVES during the Science Verification. Seven C IV and two Si IV systems were identified and accurate measurements of wavelengths over the redshift range 1.1862 < z < 1.8377 were performed. After a careful selection of pairs of lines, the ``Alkali Doublet" method with a derived analitical expression for the error analysis was applied to compute the alpha variation. The result according in magnitud order with previous doublets measurements, corresponds to one Si IV system: Delta alpha /alpha = (- 3.09 +/- 8.46) x 10-5. Data from UVES-VLT.

  19. Search for alpha variation in UVES spectra: Analysis of C IV and Si IV doublets towards QSO 1101-264

    Fiorenzano, A F M; Bonifacio, P

    2003-01-01

    Motivated by previous studies of QSO spectra that reported a variation of the fine structure constant alpha, a search for C IV and Si IV doublets was conducted in the absorption spectrum towardS QSO 1101-264, obtained by VLT-UVES during the Science Verification. Seven C IV and two Si IV systems were identified and accurate measurements of wavelengths over the redshift range 1.1862 < z < 1.8377 were performed. After a careful selection of pairs of lines, the "Alkali Doublet" method with a derived analitical expression for the error analysis was applied to compute the alpha variation. The result according in magnitud order with previous doublets measurements, corresponds to one Si IV system: Delta alpha/alpha = (- 3.09 +/- 8.46) x 10^(-5).

  20. Structure activity relationship modelling of milk protein-derived peptides with dipeptidyl peptidase IV (DPP-IV) inhibitory activity.

    Nongonierma, Alice B; FitzGerald, Richard J

    2016-05-01

    Quantitative structure activity type models were developed in an attempt to predict the key features of peptide sequences having dipeptidyl peptidase IV (DPP-IV) inhibitory activity. The models were then employed to help predict the potential of peptides, which are currently reported in the literature to be present in the intestinal tract of humans following milk/dairy product ingestion, to act as inhibitors of DPP-IV. Two models (z- and v-scale) for short (2-5 amino acid residues) bovine milk peptides, behaving as competitive inhibitors of DPP-IV, were developed. The z- and the v-scale models (p<0.05, R(2) of 0.829 and 0.815, respectively) were then applied to 56 milk protein-derived peptides previously reported in the literature to be found in the intestinal tract of humans which possessed a structural feature of DPP-IV inhibitory peptides (P at the N2 position). Ten of these peptides were synthetized and tested for their in vitro DPP-IV inhibitory properties. There was no agreement between the predicted and experimentally determined DPP-IV half maximal inhibitory concentrations (IC50) for the competitive peptide inhibitors. However, the ranking for DPP-IV inhibitory potency of the competitive peptide inhibitors was conserved. Furthermore, potent in vitro DPP-IV inhibitory activity was observed with two peptides, LPVPQ (IC50=43.8±8.8μM) and IPM (IC50=69.5±8.7μM). Peptides present within the gastrointestinal tract of human may have promise for the development of natural DPP-IV inhibitors for the management of serum glucose.

  1. Implications of oxidovanadium(IV) binding to actin.

    Ramos, Susana; Almeida, Rui M; Moura, José J G; Aureliano, Manuel

    2011-06-01

    Oxidovanadium(IV), a cationic species (VO(2+)) of vanadium(IV), binds to several proteins, including actin. Upon titration with oxidovanadium(IV), approximately 100% quenching of the intrinsic fluorescence of monomeric actin purified from rabbit skeletal muscle (G-actin) was observed, with a V(50) of 131 μM, whereas for the polymerized form of actin (F-actin) 75% of quenching was obtained and a V(50) value of 320 μM. Stern-Volmer plots were used to estimate an oxidovanadium(IV)-actin dissociation constant, with K(d) of 8.2 μM and 64.1 μM VOSO(4), for G-actin and F-actin, respectively. These studies reveal the presence of a high affinity binding site for oxidovanadium(IV) in actin, producing local conformational changes near the tryptophans most accessible to water in the three-dimensional structure of actin. The actin conformational changes, also confirmed by (1)H NMR, are accompanied by changes in G-actin hydrophobic surface, but not in F-actin. The (1)H NMR spectra of G-actin treated with oxidovanadium(IV) clearly indicates changes in the resonances ascribed to methyl group and aliphatic regions as well as to aromatics and peptide-bond amide region. In parallel, it was verified that oxidovanadium(IV) prevents the G-actin polymerization into F-actin. In the 0-200 μM range, VOSO(4) inhibits 40% of the extent of polymerization with an IC(50) of 15.1 μM, whereas 500 μM VOSO(4) totally suppresses actin polymerization. The data strongly suggest that oxidovanadium(IV) binds to actin at specific binding sites preventing actin polymerization. By affecting actin structure and function, oxidovanadium(IV) might be responsible for many cellular effects described for vanadium.

  2. Tin(IV) and lead(IV) complexes with a tetradentate redox-active ligand.

    Piskunov, Alexandr V; Trofimova, Olesya Yu; Fukin, Georgy K; Ketkov, Sergei Yu; Smolyaninov, Ivan V; Cherkasov, Vladimir K

    2012-08-28

    The coordination chemistry of a tetradentate redox-active ligand, glyoxal-bis(2-hydroxy-3,5-di-tert-butylanil) (H(2)L), was investigated with the diorganotin(IV) and diphenyllead(IV) moieties. Complexes R(2)SnL (R = Me (1), Et (2), (t)Bu (3), Ph (4)) and Ph(2)PbL (5) have been prepared and characterized. The molecular structures of compounds 1, 3, and 5 have been determined by single crystal X-ray diffraction. The diamagnetic octahedral complexes bear a tetradentate O,N,N,O redox-active ligand with a nearly planar core. Complexes 1-5 demonstrate solvatochromism in solution. The CV of complexes 1-5 reveals four one-electron redox processes. The spin density distribution in the chemically generated cations and anions of 1-5 was studied by X-band EPR spectroscopy. The experimental data agree well with the results of DFT calculations of electronic structures for 1, its pyridine adduct 1·Py, cation 1(+) and anion 1(-).

  3. Long-Term IQ Stability Using the WISC-IV and WAIS-IV among a Sample of Special Education Students

    Spector, Hayley

    2013-01-01

    The present study investigated the stability of scores on the WISC-IV and WAIS-IV over an approximate six-year period. Previous research using older versions of the WISC and WAIS have suggested that these scales demonstrate strong stability of scores. Since research that has compared the stability of scores between the WISC-IV and the WAIS-IV is…

  4. 78 FR 21491 - DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P.; Notice Seeking Exemption...

    2013-04-10

    ... ADMINISTRATION DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that DeltaPoint Capital IV, L.P. and DeltaPoint Capital IV (New York), L.P., 45 East Avenue, 6th...

  5. Type IV collagen-degrading enzyme activity in human serum.

    Hashimoto, Noriaki; Kobayashi, Michio; Watanabe,Akiharu; Higashi, Toshiro; Tsuji, Takao

    1988-01-01

    Type IV collagen-degrading enzyme activity was detected in human serum. Serum was preincubated with 4-aminophenylmercuric acetate and trypsin to activate the enzyme prior to assay. Type IV collagen, purified from human placentas and radiolabeled with [1-14C] acetic anhydride, was used as the substrate. The enzyme activity was measured at pH 7.5 and inhibited by treatment with ethylenediaminetetraacetic acid or heat. The assay of type IV collagen-degrading enzyme in human serum might be useful...

  6. A case of hereditary sensory autonomic neuropathy type IV

    G P Prashanth

    2012-01-01

    Full Text Available Hereditary sensory autonomic neuropathy type IV (HSAN -IV, also known as congenital insensitivity to pain with anhidrosis, is a very rare condition that presents in infancy with anhidrosis, absence of pain sensation and self -mutilation. Developmental delay and mental retardation are usually present. Ultrastructural study of the peripheral nerves demonstrates loss of the unmyelinated and small myelinated fibers. We here report a 8 year -old boy with HSAN IV with typical clinical features where the diagnosis was supported by nerve biopsy findings. However, our case was unusual since mental development was normal.

  7. Fire retardancy of emulsion polymerized poly (methyl methacrylate)/cerium(IV) dioxide and polystyrene/cerium(IV) dioxide nanocomposites

    Cai, Guipeng [Department of Chemistry and Fire Retardant Research Facility, Marquette University, PO Box 1881, Milwaukee, WI 53201 (United States); Lu, Hongdian [Department of Chemical and Materials Engineering, Hefei University, Hefei, Anhui 230022 (China); Zhou, You; Hao, Jianwei [School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081 (China); Wilkie, Charles A., E-mail: charles.wilkie@marquette.edu [Department of Chemistry and Fire Retardant Research Facility, Marquette University, PO Box 1881, Milwaukee, WI 53201 (United States)

    2012-12-10

    Highlights: Black-Right-Pointing-Pointer We prepare PMMA and PS containing ceria. Black-Right-Pointing-Pointer Characterization by XRD and TEM shows that some of the ceria is well-dispersed in the polymers. Black-Right-Pointing-Pointer The addition of ceria to both polymers leads to reduced thermal stability. Black-Right-Pointing-Pointer In PMMA, the fire retardancy is enhanced but there is little effect in PS. - Abstract: In situ emulsion polymerization was employed to obtain poly (methyl methacrylate) (PMMA)/cerium(IV) dioxide and polystyrene (PS)/cerium(IV) dioxide nanocomposites at two different cerium(IV) dioxide loadings (2.3 wt% and 4.6 wt%). Transmission electron microscope results indicated uniform dispersion of cerium (IV) dioxide in the polymer matrix. Both PMMA and PS nanocomposites exhibit lower thermal stability than the pristine polymers. Microscale combustion calorimeter (MCC) and cone calorimetry are used to evaluate the fire retardancy of the polymer nanocomposites. PMMA/cerium(IV) dioxide showed significant heat release rate (HRR) reduction at low loadings (<5 wt%), while PS/cerium(IV) dioxide exhibits less HRR reduction at the same loadings. An explanation of the role of cerium (IV) dioxide in fire retardancy of polymer/ceria nanocomposites based on XPS results is suggested.

  8. Complexation of Plutonium (IV) With Sulfate At Variable Temperatures

    Y. Xia; J.I. Friese; D.A> Moore; P.P. Bachelor; L. Rao

    2006-10-05

    The complexation of plutonium(IV) with sulfate at variable temperatures has been investigated by solvent extraction method. A NaBrO{sub 3} solution was used as holding oxidant to maintain the plutonium(IV) oxidation state throughout the experiments. The distribution ratio of Pu(IV) between the organic and aqueous phases was found to decrease as the concentrations of sulfate were increased. Stability constants of the 1:1 and 1:2 Pu(IV)-HSO{sub 4}{sup -} complexes, dominant in the aqueous phase, were calculated from the effect of [HSO{sub 4}{sup -}] on the distribution ratio. The enthalpy and entropy of complexation were calculated from the stability constants at different temperatures using the Van't Hoff equation.

  9. Platinum(iv) anticancer prodrugs - hypotheses and facts.

    Gibson, Dan

    2016-08-16

    In this manuscript we focus on Pt(iv) anticancer prodrugs. We explore the main working hypotheses for the design of effective Pt(iv) prodrugs and note the exceptions to the common assumptions that are prevalent in the field. Special attention was devoted to the emerging class of "dual action" Pt(iv) prodrugs, where bioactive ligands are conjugated to the axial positions of platinum in order to obtain orthogonal or complementary effects that will increase the efficacy of killing the cancer cells. We discuss the rationale behind the design of the "dual action" prodrugs and the results of the pharmacological studies obtained. Simultaneous release of two bioactive moieties inside the cancer cells often triggers several processes that together determine the fate of the cell. Pt(iv) complexes provide many opportunities for applying new concepts in targeting, synergistic cell killing and exploiting novel nanodelivery systems.

  10. 75 FR 16445 - Defense Transportation Regulation, Part IV

    2010-04-01

    ...--TSP Qualifications Attachment V.D--Rate Filing Attachment V.E--Customer Satisfaction Survey Attachment... Internet on the USTRANSCOM homepage at http:// ] www.transcom.mil/j5/pt/dtr_part_iv.cfm. Dated: March...

  11. 77 FR 16508 - National Emission Standards for Hazardous Air Pollutant Emissions: Group IV Polymers and Resins...

    2012-03-21

    ...: Group IV Polymers and Resins; Pesticide Active Ingredient Production; and Polyether Polyols Production... pollutants: National Emission Standards for Hazardous Air Pollutant Emissions: Group IV Polymers and Resins...: Group IV Polymers and Resins; Pesticide Active Ingredient Production; and Polyether Polyols...

  12. Iværksætteri ved knopskydning

    Christensen, Poul Rind; Evald, Majbritt Rostgaard

    2007-01-01

    Artiklen ser nærmere på iværksætteri ved knopskydning - hvorfor knopskydning fra eksisterende virksomheder menes at give positive bidrag til vækst og overlevelse blandt iværksætterne blandt andet ved at se på internationale undersøgelser, der er foretaget af forskellige typer af knopskydning. Art....... Artiklen kaster lys over, hvor udbredt knopskydning er som kilde til virksomhedsetableringer i Danmark. Udgivelsesdato: 6/9...

  13. Nordic Nuclear Materials Forum for Generation IV Reactors

    Anghel, C. (Studsvik Nuclear AB, Nykoeping (Sweden)); Penttilae, S. (Technical Research Centre of Finland, VTT (Finland))

    2010-03-15

    A network for material issues for Generation IV nuclear power has been initiated within the Nordic countries. The objectives of the Generation IV Nordic Nuclear Materials Forum (NOMAGE4) are to put the basis of a sustainable forum for Gen IV issues, especially focussing on fuels, cladding, structural materials and coolant interaction. Other issues include reactor physics, dynamics and diagnostics, core and fuel design. The present report summarizes the work performed during the year 2009. The efforts made include identification of organisations involved in Gen IV issues in the Nordic countries, update of the forum website, http://www.studsvik.se/GenerationIV, and investigation of capabilities for research within the area of Gen IV. Within the NOMAGE4 project a seminar on Generation IV Nuclear Energy Systems has been organized during 15-16th of October 2009. The aim of the seminar was to provide a forum for exchange of information, discussion on future research needs and networking of experts on Generation IV reactor concepts. As an outcome of the NOMAGE4, a few collaboration project proposals have been prepared/planned in 2009. The network was welcomed by the European Commission and was mentioned as an exemplary network with representatives from industries, universities, power companies and research institutes. NOMAGE4 has been invited to participate to the 'European Energy Research Alliance, EERA, workshop for nuclear structural materials' http://www.eera-set.eu/index.php?index=41 as external observers. Future plans include a new Nordic application for continuation of NOMAGE4 network. (author)

  14. IV cannula securement: protecting the patient from infection.

    Higgingson, Ray

    The use of venous cannulas to administer intravenous therapy is a common clinical intervention within the hospital setting. Once in situ, IV cannulas must be securely fixed in order to prevent their movement or displacement; as unsecured cannulas pose significant health risks, such as mechanical phlebitis and an increased risk of infection. This article explores some of the complications associated with inappropriately secured IV cannulas, along with a discussion on common securement devices.

  15. Psychological variables and Wechsler Adult Intelligence Scale-IV performance.

    Gass, Carlton S; Gutierrez, Laura

    2016-06-07

    The MMPI-2 and WAIS-IV are commonly used together in neuropsychological evaluations yet little is known about their interrelationships. This study explored the potential influence of psychological factors on WAIS-IV performance in a sample of 180 predominantly male veteran referrals that underwent a comprehensive neuropsychological examination in a VA Medical Center. Exclusionary criteria included failed performance validity testing and self-report distortion on the MMPI-2. A Principal Components Analysis was performed on the 15 MMPI-2 content scales, yielding three broader higher-order psychological dimensions: Internalized Emotional Dysfunction (IED), Externalized Emotional Dysfunction (EED), and Fear. Level of IED was not related to performance on the WAIS-IV Full Scale IQ or its four indexes: (Verbal Comprehension, Perceptual Reasoning, Working Memory, and Processing Speed). EED was not related to WAIS-IV performance. Level of Fear, which encompasses health preoccupations (HEA) and distorted perceptions (BIZ), was significantly related to WAIS-IV Full Scale IQ and Verbal Comprehension. These results challenge the common use of high scores on the MMPI-2 IED measures (chiefly depression and anxiety) to explain deficient WAIS-IV performance. In addition, they provide impetus for further investigation of the relation between verbal intelligence and Fear.

  16. Dipeptidyl peptidase IV in two human glioma cell lines

    A Sedo

    2009-12-01

    Full Text Available There is growing evidence that dipeptidyl peptidase IV [DPP-IV, EC 3.4.14.5] takes part in the metabolism of biologically active peptides participating in the regulation of growth and transformation of glial cells. However, the knowledge on the DPP-IV expression in human glial and glioma cells is still very limited. In this study, using histochemical and biochemical techniques, the DPP-IV activity was demonstrated in two commercially available human glioma cell lines of different transformation degree, as represented by U373 astrocytoma (Grade III and U87 glioblastoma multiforme (Grade IV lines. Higher total activity of the enzyme, as well as its preferential localisation in the plasma membrane, was observed in U87 cells. Compared to U373 population, U87 cells were morphologically more pleiomorphic, they were cycling at lower rate and expressing less Glial Fibrillary Acidic Protein. The data revealed positive correlation between the degree of transformation of cells and activity of DPP-IV. Great difference in expression of this enzyme, together with the phenotypic differences of cells, makes these lines a suitable standard model for further 57 studies of function of this enzyme in human glioma cells.

  17. Anti-Fibrotic Effects of Astragaloside IV in Systemic Sclerosis

    Qing Qi

    2014-11-01

    Full Text Available Objective: To evaluate the anti-fibrotic effects of Astragaloside IV in systemic sclerosis. Methods: Treated or untreated systemic sclerosis (SSc and normal fibroblast isolated from corresponding pairs were utilized to detect expression of collagen and fibronectin by western blot, quantitative real-time RT-PCR (RT-qPCR, immunofluorescence staining and histopathological examination. SSc mouse model induced by bleomycin was used to evaluate the effects of the drug in vivo. Results: Compared to normal fibroblast (NF, the expression of collagen and fibronectin in SSc (SScF dramatically increased, and this could be reduced by Astragaloside IV (AST in a dose- or time-dependent manner at both protein and mRNA levels. Administration of Astragaloside IV consistently decreased collagen formation and partially restored the structure, as well as suppressing collagen and fibronectin expression in the skin lesions of SSc-model mice. Mechanistically, Astragaloside IV-induced fibrosis reduction may be due to deregulation of Smad 3/Fli-1, the major mediators of the fibrotic response and key molecules for TGF-β signaling. Astragaloside IV also decreased the level of p-SMAD3 and completely blocked its relocation into the nuclei. Conclusion: Astragaloside IV attenuates fibrosis by inhibiting the TGF-β-Smads3 axis in systemic sclerosis.

  18. Assembling filamentous phage occlude pIV channels.

    Marciano, D K; Russel, M; Simon, S M

    2001-07-31

    Filamentous phage f1 is exported from its Escherichia coli host without killing the bacterial cell. Phage-encoded protein pIV, which is required for phage assembly and secretion, forms large highly conductive channels in the outer membrane of E. coli. It has been proposed that the phage are extruded across the bacterial outer membrane through pIV channels. To test this prediction, we developed an in vivo assay by using a mutant pIV that functions in phage export but whose channel opens in the absence of phage extrusion. In E. coli lacking its native maltooligosacharride transporter LamB, this pIV variant allowed oligosaccharide transport across the outer membrane. This entry of oligosaccharide was decreased by phage production and still further decreased by production of phage that cannot be released from the cell surface. Thus, exiting phage block the pIV-dependent entry of oligosaccharide, suggesting that phage occupy the lumen of pIV channels. This study provides the first evidence, to our knowledge, for viral exit through a large aqueous channel.

  19. The mechanism of astragaloside IV promoting sciatic nerve regeneration

    Xiaohong Zhang; Jiajun Chen

    2013-01-01

    3-O-beta-D-xylopyranosyl-6-O-beta-D-glucopyranosyl-cycloastragenol (astragaloside IV), the main active component of the traditional Chinese medicine astragalus membranaceus, has been shown to be neuroprotective. This study investigated whether astragaloside IV could promote the repair of injured sciatic nerve. Denervated sciatic nerve of mice was subjected to anastomosis. The mice were intraperitoneal y injected with 10, 5, 2.5 mg/kg astragaloside IV per day for 8 consecutive days. Western blot assay and real-time PCR results demonstrated that growth-associated protein-43 ex-pression was upregulated in mouse spinal cord segments L 4–6 after intervention with 10, 5, 2.5 mg/kg astragaloside IV per day in a dose-dependent manner. Luxol fast blue staining and elec-trophysiological detection suggested that astragaloside IV elevated the number and diameter of myelinated nerve fibers, and simultaneously increased motor nerve conduction velocity and action potential amplitude in the sciatic nerve of mice. These results indicated that astragaloside IV con-tributed to sciatic nerve regeneration and functional recovery in mice. The mechanism underlying this effect may be associated with the upregulation of growth-associated protein-43 expression.

  20. Evolution of iv iron compounds over the last century.

    Macdougall, Iain C

    2009-12-01

    Administration of intravenous (IV) iron has become pivotal in the management of anaemia in patients with chronic kidney disease (CKD). Since parenteral iron was first introduced for human use in the 1930s, things have come a long way. Seventy years ago, iron was toxic, administered as an iron oxyhydroxide complex. This problem was circumvented with the introduction of compounds containing iron in a core surrounded by a carbohydrate shell. The carbohydrate shell consists of molecules such as dextran, sucrose, dextrin or gluconate. The first dextran-containing IV iron preparations carried a small risk of anaphylaxis, but the more recently introduced low molecular weight iron dextran preparation has significantly less risk of this. Iron reactions occur with all IV iron preparations, but are generally not thought to be immune based. Recently, newer IV iron preparations have appeared in the market, including Ferumoxytol (Feraheme) and ferric carboxymaltose (Ferinject). These latest IV iron preparations do not contain a requirement for a test dose, and a much higher dose of iron can be delivered as a single administration. Thus, giving supplemental iron to man has come a long way since 1930s; we are now in an era when we are able to administer higher doses of iron with acceptable safety and without significant adverse effects. However, the long-term safety of the newer IV iron preparations is not yet established.

  1. Characterization of human and mouse peroxiredoxin IV: Evidence for inhibition by Prx-IV of epidermal growth factor- and p53-induced reactive oxygen species

    Wong, CM; Kok, KH; Jin, DY; Chun, ACS; Zhou, Y.; Fung, PCW; Kung, HF; Jeang, KT

    2000-01-01

    The aim of this study was to identify and characterize human and mouse Prx-IV. We identified mouse peroxiredoxin IV (Prx-IV) by virtue of sequence homology to its human ortholog previously called AOE372. Mouse Prx-IV conserves an amino-terminal presequence coding for signal peptide. The amino acid sequences of mature mouse and human Prx-IV share 97.5% identity. Phylogenetic analysis demonstrates that Prx-IV is more closely related to Prx-I/-II/-III than to Prx-V/-VI. Previously, we mapped the...

  2. Carbonate complexation of Np(IV) in alkaline solutions

    Kitamura, Akira [Japan Nuclear Cycle Development Inst., Tokai Works, Tokai, Ibaraki (Japan); Kohara, Yukitoshi [Inspection Development Company Ltd., Tokai, Ibaraki (Japan)

    2002-12-01

    Reliable thermodynamic data for actinide (IV) have been required. The solubility of Np(IV) in carbonate media was studied for determination of thermodynamic data. The concentration of dissolved Np(IV) was measured with ionic strengths from 0.5 to 2.9 M (M {identical_to} mol{center_dot}dm{sup -3}), hydrogen-ion concentration exponent (pH{sub c} = -log[H{sup +}]) from 8 to 13 and with the total carbonate concentration (C{sub T}) from 5x10{sup -3} M to 7x10{sup -1} M by an oversaturation method. It was found that the solubility of Np(IV) decreased with increasing pH{sub c} and increased with increasing C{sub T}. On the basis of analysis of the solubility data, the dominant aqueous species of Np(IV) were expected to be Np(CO{sub 3}){sub 4}{sup 4-}, Np(CO{sub 3}){sub 2}(OH){sub 2}{sup 2-} and Np(CO{sub 3}){sub 2}(OH){sub 4}{sup 4-} in the present study. The apparent equilibrium constants of the carbonate and carbonatohydroxo complexes were obtained in the respective ionic strength and the equilibrium constants at the zero ionic strength were extrapolated. The obtained equilibrium constants supported the literature values strongly, and contributed to improve the reliability of the thermodynamic data. (author)

  3. Astragaloside IV ameliorates renal injury in db/db mice

    Sun, Huili; Wang, Wenjing; Han, Pengxun; Shao, Mumin; Song, Gaofeng; Du, Heng; Yi, Tiegang; Li, Shunmin

    2016-09-01

    Diabetic nephropathy is a lethal complication of diabetes mellitus and a major type of chronic kidney disease. Dysregulation of the Akt pathway and its downstream cascades, including mTOR, NFκB, and Erk1/2, play a critical role in the development of diabetic nephropathy. Astragaloside IV is a major component of Huangqi and exerts renal protection in a mouse model of type 1 diabetes. The current study was undertaken to investigate the protective effects of diet supplementation of AS-IV on renal injury in db/db mice, a type 2 diabetic mouse model. Results showed that administration of AS-IV reduced albuminuria, ameliorated changes in the glomerular and tubular pathology, and decreased urinary NAG, NGAL, and TGF-β1 in db/db mice. AS-IV also attenuated the diabetes-related activation of Akt/mTOR, NFκB, and Erk1/2 signaling pathways without causing any detectable hepatotoxicity. Collectively, these findings showed AS-IV to be beneficial to type 2 diabetic nephropathy, which might be associated with the inhibition of Akt/mTOR, NFκB and Erk1/2 signaling pathways.

  4. Solar neutrino measurements in Super-Kamiokande-IV

    Abe, K.; Haga, Y.; Hayato, Y.; Ikeda, M.; Iyogi, K.; Kameda, J.; Kishimoto, Y.; Marti, Ll.; Miura, M.; Moriyama, S.; Nakahata, M.; Nakajima, T.; Nakayama, S.; Orii, A.; Sekiya, H.; Shiozawa, M.; Sonoda, Y.; Takeda, A.; Tanaka, H.; Takenaga, Y.; Tasaka, S.; Tomura, T.; Ueno, K.; Yokozawa, T.; Akutsu, R.; Irvine, T.; Kaji, H.; Kajita, T.; Kametani, I.; Kaneyuki, K.; Lee, K. P.; Nishimura, Y.; McLachlan, T.; Okumura, K.; Richard, E.; Labarga, L.; Fernandez, P.; Blaszczyk, F. d. M.; Gustafson, J.; Kachulis, C.; Kearns, E.; Raaf, J. L.; Stone, J. L.; Sulak, L. R.; Berkman, S.; Tobayama, S.; Goldhaber, M.; Bays, K.; Carminati, G.; Griskevich, N. J.; Kropp, W. R.; Mine, S.; Renshaw, A.; Smy, M. B.; Sobel, H. W.; Takhistov, V.; Weatherly, P.; Ganezer, K. S.; Hartfiel, B. L.; Hill, J.; Keig, W. E.; Hong, N.; Kim, J. Y.; Lim, I. T.; Park, R. G.; Akiri, T.; Albert, J. B.; Himmel, A.; Li, Z.; O'Sullivan, E.; Scholberg, K.; Walter, C. W.; Wongjirad, T.; Ishizuka, T.; Nakamura, T.; Jang, J. S.; Choi, K.; Learned, J. G.; Matsuno, S.; Smith, S. N.; Friend, M.; Hasegawa, T.; Ishida, T.; Ishii, T.; Kobayashi, T.; Nakadaira, T.; Nakamura, K.; Nishikawa, K.; Oyama, Y.; Sakashita, K.; Sekiguchi, T.; Tsukamoto, T.; Nakano, Y.; Suzuki, A. T.; Takeuchi, Y.; Yano, T.; Cao, S. V.; Hayashino, T.; Hiraki, T.; Hirota, S.; Huang, K.; Ieki, K.; Jiang, M.; Kikawa, T.; Minamino, A.; Murakami, A.; Nakaya, T.; Patel, N. D.; Suzuki, K.; Takahashi, S.; Wendell, R. A.; Fukuda, Y.; Itow, Y.; Mitsuka, G.; Muto, F.; Suzuki, T.; Mijakowski, P.; Frankiewicz, K.; Hignight, J.; Imber, J.; Jung, C. K.; Li, X.; Palomino, J. L.; Santucci, G.; Taylor, I.; Vilela, C.; Wilking, M. J.; Yanagisawa, C.; Fukuda, D.; Ishino, H.; Kayano, T.; Kibayashi, A.; Koshio, Y.; Mori, T.; Sakuda, M.; Takeuchi, J.; Yamaguchi, R.; Kuno, Y.; Tacik, R.; Kim, S. B.; Okazawa, H.; Choi, Y.; Ito, K.; Nishijima, K.; Koshiba, M.; Totsuka, Y.; Suda, Y.; Yokoyama, M.; Bronner, C.; Calland, R. G.; Hartz, M.; Martens, K.; Obayashi, Y.; Suzuki, Y.; Vagins, M. R.; Nantais, C. M.; Martin, J. F.; de Perio, P.; Tanaka, H. A.; Konaka, A.; Chen, S.; Sui, H.; Wan, L.; Yang, Z.; Zhang, H.; Zhang, Y.; Connolly, K.; Dziomba, M.; Wilkes, R. J.; Super-Kamiokande Collaboration

    2016-09-01

    Upgraded electronics, improved water system dynamics, better calibration and analysis techniques allowed Super-Kamiokande-IV to clearly observe very low-energy 8B solar neutrino interactions, with recoil electron kinetic energies as low as ˜3.5 MeV . Super-Kamiokande-IV data-taking began in September of 2008; this paper includes data until February 2014, a total livetime of 1664 days. The measured solar neutrino flux is (2.308 ±0.020 (stat)-0.040 +0.039(syst ))×1 06/(cm2 sec ) assuming no oscillations. The observed recoil electron energy spectrum is consistent with no distortions due to neutrino oscillations. An extended maximum likelihood fit to the amplitude of the expected solar zenith angle variation of the neutrino-electron elastic scattering rate in SK-IV results in a day/night asymmetry of (-3.6 ±1.6 (stat )±0.6 (syst ))% . The SK-IV solar neutrino data determine the solar mixing angle as sin2θ12=0.327-0.031+0.026 , all SK solar data (SK-I, SK-II, SK III and SK-IV) measures this angle to be sin2θ12=0.334-0.023+0.027 , the determined mass-squared splitting is Δ m212=4.8-0.8+1.5×10-5 eV2 .

  5. Does WISC-IV Underestimate the Intelligence of Autistic Children?

    Nader, Anne-Marie; Courchesne, Valérie; Dawson, Michelle; Soulières, Isabelle

    2016-05-01

    Wechsler Intelligence Scale for Children (WISC) is widely used to estimate autistic intelligence (Joseph in The neuropsychology of autism. Oxford University Press, Oxford, 2011; Goldstein et al. in Assessment of autism spectrum disorders. Guilford Press, New York, 2008; Mottron in J Autism Dev Disord 34(1):19-27, 2004). However, previous studies suggest that while WISC-III and Raven's Progressive Matrices (RPM) provide similar estimates of non-autistic intelligence, autistic children perform significantly better on RPM (Dawson et al. in Psychol Sci 18(8):657-662, doi: 10.1111/j.1467-9280.2007.01954.x , 2007). The latest WISC version introduces substantial changes in subtests and index scores; thus, we asked whether WISC-IV still underestimates autistic intelligence. Twenty-five autistic and 22 typical children completed WISC-IV and RPM. Autistic children's RPM scores were significantly higher than their WISC-IV FSIQ, but there was no significant difference in typical children. Further, autistic children showed a distinctively uneven WISC-IV index profile, with a "peak" in the new Perceptual Reasoning Index. In spite of major changes, WISC-IV FSIQ continues to underestimate autistic intelligence.

  6. Effect of bowel obstruction on stage IV colorectal cancer.

    Chen, Wei; Tan, Xiao-Ping; Ye, Jun-Wen; Liu, Qin; Zeng, Qingli; Wang, Lei; Wang, Jian-Ping

    2014-03-01

    Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, with a high mortality rate, particularly among patients with advanced-stage disease complicated by bowel obstruction. The present study aimed to investigate the value of different surgical procedures and potential predictors of survival for patients with stage IV CRC, with or without bowel obstruction. Between August, 1994 and December, 2005, a total of 2,950 CRC patients were diagnosed and treated at our hospital. Among these, 381 patients had stage IV disease and were divided into two groups according to the presence (n=295) or absence (n=86) of bowel obstruction. The clinical data of all the patients with stage IV CRC were retrospectively analyzed and all the patients were followed up. Our results demonstrated statistically significant differences in gender, radical resection, histological type, ascites, tumor location, peritoneal and liver metastases between the obstruction and non-obstruction groups. We also observed that hepatic metastases and radical resection were factors associated with prognosis according to the univariate and multivariate analyses. Furthermore, the mean/median survival time was 49.4/21.6 and 37.2/17.1 months in the non-obstruction and obstruction groups, respectively. In conclusion, obstruction was not found to be an independent indicator of survival for patients with stage IV CRC, with patients in the obstruction group exhibiting a worse overall survival compared to those in the non-obstruction group, whereas active radical surgery significantly improved the prognosis of patients with stage IV CRC.

  7. A COMPARATIVE CLINICAL STUDY BETWEEN IV ESMOLOL AND IV FENTANYL ON ATTENUATION OF HAEMODYNAMIC RESPONSES TO LARYNGOSCOPY AND INTUBATION

    Abu Lais Mustaque

    2016-04-01

    Full Text Available INTRODUCTION Laryngoscopy and intubation is an integral part for providing general anaesthesia to patients undergoing various types of surgery. It also plays an important role in critical care units viz. for providing mechanical ventilation. It is a very essential tool in the hands of anaesthesiologist in maintaining airway. The present study is undertaken to determine and compare the efficacy of single bolus dose of IV esmolol 1 mg/kg and IV fentanyl 2 mcg/kg in attenuating the haemodynamic responses to laryngoscopy and tracheal intubation and to ascertain the effectiveness of esmolol hydrochloride and fentanyl citrate in suppressing sympathetic responses. MATERIAL & METHODS The study was conducted under the Department of Anaesthesiology and Critical Care, Assam Medical College and Hospital, Dibrugarh, during the period July 2013 to June 2014. For this purpose, 150 patients of either sex between 20-50 years of ASA I & II physical status were selected after obtaining informed and written consent and were divided into two groups namely, Group E receiving IV esmolol (1 mg/kg and Group F receiving IV fentanyl (2 mcg/kg. RESULTS Inj. fentanyl 2 mcg/kg IV administered 5 minutes before laryngoscopy and intubation was able to prevent adverse haemodynamic changes better than Inj. esmolol 1 mg/kg IV administered 3 minutes prior to laryngoscopy and intubation during elective surgeries under general anaesthesia. CONCLUSION Hence, from the findings of this study we can conclude that IV bolus dose of fentanyl 2 mcg/kg administered 5 minutes before laryngoscopy and intubation can attenuate the sympathetic response to laryngoscopy and intubation without any side effects of the drug in healthy patients undergoing elective surgeries under general anaesthesia.

  8. Importación de cierres de cremallera para la industria textil peruana, en el marco de las preferencias arancelarias CAN (2003-2006)

    2011-01-01

    Objetivo: Establecer en qué medida la importación de cierres de cremallera eleva la ventaja competitiva en la industria textil del Perú en el marco de los regímenes aduaneros vigentes y las preferencias arancelarias de la CAN. Método: No experimental y de tipo transversal correlacional. Resultados: Las características más resaltantes del mercado local de cierres con respecto a la demanda de la industria son: variedad en tamaños y colores, precios, calidad y la respectiva disponibilidad del pr...

  9. A Comparative Evaluation of Pisa 2003-2006 Results in Reading Literacy Skills: An Example of Top-Five OECD Countries and Turkey

    Aydin, Ayhan; Erdagf, Coskun; Tas, Nuray

    2011-01-01

    In this study it is aimed to describe and evaluate comparatively the reading literacy exam results, the finance of education and schools, and socio-cultural status of parents in Turkey and the top-five OECD countries, Finland, Korea, Canada, Australia, New Zealand respectively, in the light reports and publications by OECD regarding PISA 2003 and…

  10. Survey of characteristics of neonatal death in neonatal intensive care unit of Boo-Ali Sina educational & therapeutic center between 2003-2006

    Azita Bala Ghafari

    2009-01-01

    Full Text Available , , , (Received 24 June, 2009 ; Accepted 16 September, 2009AbstractBackground and purpose: The neonatal mortality rate is an important index for evaluation of public health. It involves the death of infants under 28 days. Obviously, recognizing the characteristics of neonatal mortality in this center, may be useful for promoting the procedures in the NICU, as well as planning to impede the severe complications or death.Materials and methods: This is a descriptive study performed by analyzing the available data from the medical records of NICU patients at Boo-Ali Sina Educational & Therapeutic Center during 2003 and 2006. The number of deaths, names, and medical records number of the dead infants were collected. Among 1238 patients in the NICU, 363 deaths were reported. According to medical records, 222 deaths occurred in neonates aged 0 to 27 days. Data were collected using a checklist, the validity and reliability of which were approved by clinicians. The Descriptive methods were used in analyzing the data.Results: The findings include: 140 subjects were male (63.1%; 72 from single birth (77.5%; the age-group of mothers of 38 cases (37.7% was 20-24 y; 132 cases (59.5% resided in villages; 129 cases (58.1% with prenatal care; 120 cased of Caesarian section (54%; 155 cases (76% with birth weight lower than 2500 grams and 154 preterm (75.5%. Mortality during neonatal period was divided in two groups: early death (0-6 days 142 cases (62% and late death (7-27 days 80 cases (36%.Conclusion: Correct and exact completion of NICU forms would help undertaking descriptive and analytic epidemiologic studies.Key words: Neonatal mortality, early neonatal mortality, late neonatal mortality, NICUJ Mazand Univ Med Sci 2009; 20(74: 79-83 (Persian

  11. Fruit juice consumption is associated with improved nutrient adequacy in children and adolescents: The National Health and Nutrition Examination Survey (NHANES) 2003-2006

    The goal of the study was to examine the contribution of 100% fruit juice consumption to dietary adequacy of shortfall nutrients by children and adolescents. This was a cross-sectional study and used data from the 2003–2006 National Health and Nutrition Examination Survey (NHANES). Participants were...

  12. Impact of orange juice consumption on bone health of the U.S. population in the national health and nutrition examination survey 2003-2006.

    Lee, Sang Gil; Yang, Meng; Wang, Ying; Vance, Terrence; Lloyd, Beate; Chung, Sang-Jin; Koo, Sung I; Chun, Ock K

    2014-10-01

    Orange juice (OJ) fortified with calcium (Ca) and vitamin D has turned OJ into a readily available source of these nutrients for children and adults. However, the impact of OJ consumption on Ca and vitamin D adequacy and bone health has not been documented. The aim of this study was the evaluation of the contribution of 100% OJ consumption to dietary and serum Ca and vitamin D status, and bone health parameters in the U.S. population aged 4 years and older (n=13,971) using the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and 2005-2006. Food consumption data were coded to produce micronutrient intake values using the USDA Food and Nutrient Database for Dietary Studies 3.0. Serum concentrations of bone-related micronutrients and biomarkers, bone mineral density (BMD), and bone mineral content (BMC) were measured. Analysis of data was conducted using SAS software 9.2 and SUDAAN. OJ consumers showed higher intakes of bone-related micronutrients, compared with nonconsumers (P<.05). In addition, OJ consumers had higher serum Ca levels in adults (P<.01) and had a lower odds ratio for serum 25-hydroxyvitamin D3 <20 ng/mL in children (P<.05). OJ consumption was positively associated with femur BMD in children (P<.05) and with femur BMC in both children and adults (P<.05). In conclusion, OJ may be recommended as an effective dietary means of improving the status of Ca and vitamin D, acid-base balance, and of promoting bone health in children and adults.

  13. Risk of venous thromboembolism after total hip and knee replacement in older adults with comorbidity and co-occurring comorbidities in the Nationwide Inpatient Sample (2003-2006

    Katz Jeffrey N

    2010-09-01

    Full Text Available Abstract Background Venous thromboembolism is a common, fatal, and costly injury which complicates major surgery in older adults. The American College of Chest Physicians recommends high potency prophylaxis regimens for individuals undergoing total hip or knee replacement (THR or TKR, but surgeons are reluctant to prescribe them due to fear of excess bleeding. Identifying a high risk cohort such as older adults with comorbidities and co-occurring comorbidities who might benefit most from high potency prophylaxis would improve how we currently perform preoperative assessment. Methods Using the Nationwide Inpatient Sample, we identified older adults who underwent THR or TKR in the U.S. between 2003 and 2006. Our outcome was VTE, including any pulmonary embolus or deep venous thrombosis. We performed multivariate logistic regression analyses to assess the effects of comorbidities on VTE occurrence. Comorbidities under consideration included coronary artery disease, congestive heart failure (CHF, chronic obstructive pulmonary disease (COPD, diabetes, and cerebrovascular disease. We also examined the impact of co-occurring comorbidities on VTE rates. Results CHF increased odds of VTE in both the THR cohort (OR = 3.08 95% CI 2.05-4.65 and TKR cohort (OR = 2.47 95% CI 1.95-3.14. COPD led to a 50% increase in odds in the TKR cohort (OR = 1.49 95% CI 1.31-1.70. The data did not support synergistic effect of co-occurring comorbidities with respect to VTE occurrence. Conclusions Older adults with CHF undergoing THR or TKR and with COPD undergoing TKR are at increased risk of VTE. If confirmed in other datasets, these older adults may benefit from higher potency prophylaxis.

  14. Ground-Water Recharge in Humid Areas of the United States--A Summary of Ground-Water Resources Program Studies, 2003-2006

    Delin, Geoffrey N.; Risser, Dennis W.

    2007-01-01

    Increased demands on water resources by a growing population and recent droughts have raised awareness about the adequacy of ground-water resources in humid areas of the United States. The spatial and temporal variability of ground-water recharge are key factors that need to be quantified to determine the sustainability of ground-water resources. Ground-water recharge is defined herein as the entry into the saturated zone of water made available at the water-table surface, together with the associated flow away from the water table within the saturated zone (Freeze and Cherry, 1979). In response to the need for better estimates of ground-water recharge, the Ground-Water Resources Program (GWRP) of the U.S. Geological Survey (USGS) began an initiative in 2003 to estimate ground-water recharge rates in the relatively humid areas of the United States.

  15. Coordination Chemistry of Homoleptic Actinide(IV)-Thiocyanate Complexes.

    Carter, Tyler J; Wilson, Richard E

    2015-10-26

    The synthesis, X-ray crystal structure, vibrational and optical spectroscopy for the eight-coordinate thiocyanate compounds, [Et4 N]4 [Pu(IV) (NCS)8 ], [Et4 N]4 [Th(IV) (NCS)8 ], and [Et4 N]4 [Ce(III) (NCS)7 (H2 O)] are reported. Thiocyanate was found to rapidly reduce plutonium to Pu(III) in acidic solutions (pHcoordination in acetonitrile based on the observation of intense ligand-to-metal charge-transfer bands. Spectroscopic and crystallographic data do not support the interaction of the metal orbitals with the ligand π system, but support an enhanced An(IV) -NCS interaction, as the Lewis acidity of the metal ion increases from Th to Pu.

  16. Court Culture during the Reign of Christian IV

    Olden-Jørgensen, Sebastian

    2007-01-01

    Court culture can be defined as a range of cultural forms (festival culture, painting, literature, music, architecture) employed for the enhancement of princely status and the communication of political messages. Christian IV evidently set great store on court culture beginning with his magnificent...... coronation in 1596, reaching a climax with the "great wedding" (of crown prince Christian) in 1634 and at last colapsing during the military and political crisis in the last years of his long reign (1588/96-1648). Danish court culture during the reign of Christian IV decidedly was on an European level......, and during the Thirty Years War he could even profit from the plight of fellow princes in germany and engage top artists like the composer Heinrich Schütz. The court culture of Christian IV was a succes in the sense that during the first part of his reign it underscored his success and status. During...

  17. Relative subtest scatter in the WAIS-IV standardization sample.

    Binder, Laurence M; Binder, Adrienne L

    2011-01-01

    The frequencies of differences between highest and lowest subtest scores as a function of highest subtest score (relative scatter), are reported for the standardization sample of the Wechsler Adult Intelligence Scale-IV (WAIS-IV). Large differences between highest and lowest subtest scores were common. The degree of relative scatter was related to the height of the highest subtest score. For the 10 core WAIS-IV subtests, the correlation between the level of the highest subtest score and the amount of scatter was r = .62; for all 15 subtests the correlation was. 63. The level of the highest subtest score was more strongly related to scatter than was Full Scale IQ. Clinical implications for inferring cognitive impairment and estimating premorbid abilities are discussed. When considering the possibility of acquired cognitive impairment, we recommend caution in the interpretation of subtest score differences.

  18. The SDSS-IV in 2014: A Demographic Snapshot

    Lundgren, Britt; Zasowski, Gail; Lucatello, Sara; Diamond-Stanic, Aleksandar M; Tremonti, Christy A; Myers, Adam D; Aragon-Salamanca, Alfonso; Gillespie, Bruce; Ho, Shirley; Gallagher, John S

    2015-01-01

    Many astronomers now participate in large international collaborations, and it is important to examine whether these structures foster a scientific climate that is inclusive and diverse. The Committee on the Participation of Women in the Sloan Digital Sky Survey (CPWS) was formed to evaluate the demographics and gender climate within SDSS-IV, one of the largest and most geographically distributed astronomical collaborations. In April 2014, the CPWS administered a demographic survey to establish a baseline for the incipient SDSS-IV. We received responses from 250 participants (46% of the active membership). Half of the survey respondents were located in the US or Canada and 30% were based in Europe. Eleven percent of survey respondents considered themselves to be an ethnic minority at their current institution. Twenty-five percent of the SDSS-IV collaboration members are women, a fraction that is consistent with the US astronomical community, but substantially higher than the fraction of women in the IAU (16%)...

  19. Hydration and hydrolysis of thorium(IV) in aqueous solution and the structures of two crystalline thorium(IV) hydrates.

    Torapava, Natallia; Persson, Ingmar; Eriksson, Lars; Lundberg, Daniel

    2009-12-21

    Solid octaaqua(kappa(2)O-perchlorato)thorium(IV) perchlorate hydrate, [Th(H(2)O)(8)(ClO(4))](ClO(4))(3).H(2)O, 1, and aquaoxonium hexaaquatris(kappaO-trifluoromethanesulfonato)thorium(IV) trisaquahexakis(kappaO-trifluoromethanesulfonato)thorinate(IV), H(5)O(2)[Th(H(2)O)(6)(OSO(2)CF(3))(3)][Th(H(2)O)(3)(OSO(2)CF(3))(6)], 2, were crystallized from concentrated perchloric and trifluoromethanesulfonic acid solutions, respectively. 1 adopts a severely distorted tricapped trigonal prismatic configuration with an additional oxygen from the perchlorate ion at a longer distance. 2 consists of individual hexaaquatris(kappaO-trifluoromethanesulfonato)thorium(IV) and trisaquahexakis(kappaO-trifluoromethanesulfonato)thorinate(IV) ions and an aquaoxonium ion bridging these two ions through hydrogen bonding. The hydrated thorium(IV) ion is nine-coordinated in aqueous solution as determined by extended X-ray absorption fine structure (EXAFS) and large angle X-ray scattering (LAXS). The LAXS studies also showed a second hydration sphere of about 18 water molecules, and traces of a 3rd hydration sphere. Structural studies in aqueous solution of the hydrolysis products of thorium(IV) have identified three different types of hydrolysis species: a mu(2)O-hydroxo dimer, [Th(2)(OH)(2)(H(2)O)(12)](6+), a mu(2)O-hydroxo tetramer, [Th(4)(OH)(8)(H(2)O)(16)](8+), and a mu(3)O-oxo hexamer, [Th(6)O(8)(H(2)O)(n)](8+). Detailed structures of these three hydrolysis species are given. A compilation of reported solid state structures of actinoid(IV) compounds with oxygen donor ligands show a strong correlation between the An-O bond distance and the coordination number. The earlier reported U-O bond distance in the hydrated uranium(IV) ion in aqueous solution, confirmed in this study, is related to nine-coordination. The hydrated tri- and tetravalent actinoid ions in aqueous solution all seem to be nine-coordinated. The trivalent ions show a significant difference in bond distance to prismatic and

  20. J-Integral characterization of the nozzle steels from intermediate test vessels IV-5 and IV-9

    Auten, T.A.; Macdonald, B.D.; Scavone, D.W.; Bozik, D.

    1994-10-01

    Reported here are the results of elastic-plastic fracture toughness tests performed on low alloy steels from the nozzles of the intermediate test vessels IV-5 and IV-9 from the Heavy Steel Section Technology Program at Oak Ridge National Laboratory. These vessels had been given prototypic nozzle corner flaw tests prior to the development of the ASTM E-813 standard test procedure for J-integral testing. The objective of this work is to provide J-integral material test support for future elastic-plastic fracture mechanics analysis of the nozzles. J-integral tests at 88{degrees}C (190{degrees}F) of the IV-5 nozzle material produced stable ductile tearing. The tearing resistance data are expected to support analysis of the observed similar stable tearing response of the nozzle corner flaw. J-integral tests at 24{degrees}C (75{degrees}F) of the IV-9 nozzle produced elastic-plastic fracture instability preceded by stable tearing. A similar response was observed in the IV-9 nozzle corner flaw test. It will be a major and important challenge to develop a fracture mechanics rationale that reconciles these small specimen and nozzle corner flaw test results. These test results are being made available to allow their use by a wide variety of organizations in developing such a rationale, which would be a significant contribution to quantifying the flaw tolerance of reactor pressure vessels.

  1. Tethys and Annex IV Progress Report for FY 2012

    Hanna, Luke A.; Butner, R. Scott; Whiting, Jonathan M.; Copping, Andrea E.

    2013-09-01

    The marine and hydrokinetic (MHK) environmental Impacts Knowledge Management System, dubbed “Tethys” after the mythical Greek titaness of the seas, is being developed by the Pacific Northwest National Laboratory (PNNL) to support the U.S. Department of Energy’s Wind and Water Power Program (WWPP). Functioning as a smart database, Tethys enables its users to identify key words or terms to help gather, organize and make available information and data pertaining to the environmental effects of MHK and offshore wind (OSW) energy development. By providing and categorizing relevant publications within a simple and searchable database, Tethys acts as a dissemination channel for information and data which can be utilized by regulators, project developers and researchers to minimize the environmental risks associated with offshore renewable energy developments and attempt to streamline the permitting process. Tethys also houses a separate content-related Annex IV data base with identical functionality to the Tethys knowledge base. Annex IV is a collaborative project among member nations of the International Energy Agency (IEA) Ocean Energy Systems – Implementing Agreement (OES-IA) that examines the environmental effects of ocean energy devices and projects. The U.S. Department of Energy leads the Annex IV working with federal partners such as the Federal Energy Regulatory Commission (FERC), the Bureau of Ocean Energy Management (BOEM), and the National Oceanic Atmospheric Administration (NOAA). While the Annex IV database contains technical reports and journal articles, it is primarily focused on the collection of project site and research study metadata forms (completed by MHK researchers and developers around the world, and collected by PNNL) which provide information on environmental studies and the current progress of the various international MHK developments in the Annex IV member nations. The purpose of this report is to provide a summary of the content

  2. Supramolecular organotin(IV) dithiocarboxylates as potential antimicrobial agents

    Zia-ur-Rehman, [No Value; Muhammady, Niaz; Shah, Afzal; Ali, Saqib; Butler, Ian S.; Meetsma, Auke

    2012-01-01

    A series of tri-, chlorodi-, and diorganotin(IV) derivatives of 4-(2-methoxyphenyl) piperazine-1-carbodithioate (L) {R = n-C4H9 (1), C6H11 (2), CH3 (3) and C6H5 (4)}, (n-C4H9)(2)SnClL (5) and R2SnL2 {R = n-C4H9 (6), C2H5 (7), CH3 (8)} have been synthesized by refluxing organotin(IV) chlorides with t

  3. Why IV Setup for Stream Ciphers is Difficult

    Zenner, Erik

    2007-01-01

    In recent years, the initialization vector (IV) setup has proven to be the most vulnerable point when designing secure stream ciphers. In this paper, we take a look at possible reasons why this is the case, identifying numerous open research problems in cryptography.......In recent years, the initialization vector (IV) setup has proven to be the most vulnerable point when designing secure stream ciphers. In this paper, we take a look at possible reasons why this is the case, identifying numerous open research problems in cryptography....

  4. Driver for solar cell i-v characteristic plots

    Turner, G.B.

    1980-01-15

    A bipolar voltage ramp generator applies a linear voltage through a resistor to a solar cell for plotting its current versus voltage (I-v) characteristic between short circuit and open circuit conditions, with automatic stops at the end points. The resistor serves the multiple purpose of providing a current sensing resistor, setting the full-scale current value, and providing a load line with a slope approximately equal to one, such that it will pass through the origin and the approximate center of the i-v curve with about equal distance from that center to each of the end points.

  5. (Benzyl phenyl sulfoxide-κO)dichloridodiphenyl­tin(IV)

    Guo-Xia Tan; Chang-Fa Zhang; Xi-Cheng Liu

    2011-01-01

    The SnIV atom in the title compound, [Sn(C6H5)2Cl2(C13H12OS)], displays a distorted C2Cl2O trigonal–bipyramidal coordination environment, with a mean Sn—C distance of 2.121 (9) Å and with Sn—O = 2.331 (2) Å. The SnIV atom is displaced by 0.169 (2) Å from the equatorial C2Cl plane towards the direction of the second axially bonded Cl atom.

  6. Respiratory complications of Ehlers-Danlos syndrome type IV.

    Dowton, S B; Pincott, S; Demmer, L

    1996-12-01

    Pulmonary complications are described in a case of Ehlers-Danlos syndrome type IV, established by studies of collagen biosynthesis. At age 20.5 years the patient, who had previously suffered a spontaneous colonic perforation, developed intermittent recurrent hemoptysis and had a spontaneous hemopneumothorax. At presentation, imaging studies revealed multiple scattered cavitary lesions in both lungs. On separate occasions large parenchymal cysts ensued and subsequently regressed. Reviews of other reported patients indicate that pulmonary complications do occur in patients with Ehlers-Danlos syndrome type IV but have not resulted directly in patient mortality.

  7. Interaction of local anesthetics with a peptide encompassing the IV/S4-S5 linker of the Na+ channel.

    Fraceto, Leonardo F; Oyama, Sérgio; Nakaie, Clóvis R; Spisni, Alberto; de Paula, Eneida; Pertinhez, Thelma A

    2006-08-20

    The peptide pIV/S4-S5 encompasses the cytoplasmic linker between helices S4-S5 in domain IV of the voltage-gated Na+ channel, residues 1644-1664. The interaction of two local anesthetics (LA), lidocaine and benzocaine, with pIV/S4-S5 has been studied by DOSY, heteronuclear NMR 1H-15N-HSQC spectroscopy and computational methods. DOSY indicates that benzocaine, a neutral ester, exhibits stronger interaction with pIV/S4-S5 than lidocaine, a charged amine-amide. Weighted average chemical shifts, Deltadelta(1H-15N), show that benzocaine affects residues L1653, M1655 and S1656 while lidocaine slightly perturbs residues I1646, L1649 and A1659, L1660, near the N- and C-terminus, respectively. Computational methods confirmed the stability of the benzocaine binding and the existence of two binding sites for lidocaine. Even considering that the approach of studying the peptide in the presence of a co-solvent (TFE/H2O, 30%/70% v/v) has an inherently limited implication, our data strongly support the existence of multiple LA binding sites in the IV/S4-S5 linker, as suggested in the literature. In addition, we consider that LA can bind to the S4-S5 linker with diverse binding modes and strength since this linker is part of the receptor for the "inactivation gate particle". Conditions for devising new functional studies, aiming to better understand Na+ channel functionality as well as the various facets of LA pharmacological activity are proposed in this work.

  8. Bionic self-sufficient greenhouses and cattle breeding. Agrosphere IV; Bionisch autarkische glastuinbouw en veeteelt. Agrosphere IV

    Schmitz, A.H.H. [VERWOL Klimaatplafonds, Delft (Netherlands)

    2007-09-15

    Agrosphere-IV is a concept in which cattle breeding and greenhouse culture are combined in an artificial cycle which functions similar to the cycles on earth. In this article attention is paid to the combination of greenhouses for the production of paprikas (peppers) or tomatoes and breeding of pigs (porkers) [Dutch] Met de ontwikkeling van Agrosphere-IV is een vierde biosfeerconcept benoemd. Waar huidige agroconcepten nog uitgaan van samenvoeging van traditionele veeteelt- en glastuinbouwconcepten betreft het hier een directe koppeling van veeteelt en glastuinbouw. De koppeling heeft plaats via uitgekiende luchtstromen en hergebruik van de afvalstromen en vormt zo een bionisch autarkisch systeem.

  9. Solar Neutrino Measurements in Super-Kamiokande-IV

    :,; Haga, Y; Hayato, Y; Ikeda, M; Iyogi, K; Kameda, J; Kishimoto, Y; Marti, Ll; Miura, M; Moriyama, S; Nakahata, M; Nakajima, T; Nakayama, S; Orii, A; Sekiya, H; Shiozawa, M; Sonoda, Y; Takeda, A; Tanaka, H; Takenaga, Y; Tasaka, S; Tomura, T; Ueno, K; Yokozawa, T; Akutsu, R; Irvine, T; Kaji, H; Kajita, T; Kametani, I; Kaneyuki, K; Lee, K P; Nishimura, Y; McLachlan, T; Okumura, K; Richard, E; Labarga, L; Fernandez, P; Blaszczyk, F d M; Gustafson, J; Kachulis, C; Kearns, E; Raaf, 32 J L; Stone, J L; Sulak, 32 L R; Berkman, S; Tobayama, S; Goldhaber, M; Bays, K; Carminati, G; Griskevich, N J; Kropp, W R; Mine, S; Renshaw, A; Smy, M B; Sobel, H W; Takhistov, V; Weatherly, P; Ganezer, K S; Hartfiel, B L; Hill, J; Keig, W E; Hong, N; Kim, J Y; Lim, I T; Park, R G; Akiri, T; Albert, J B; Himmel, A; Li, Z; O'Sullivan, E; Scholberg, K; Walter, C W; Wongjirad, T; Ishizuka, T; Nakamura, T; Jang, J S; Choi, K; Learned, J G; Matsuno, S; Smith, S N; Friend, M; Hasegawa, T; Ishida, T; Ishii, T; Kobayashi, T; Nakadaira, T; Nakamura, K; Nishikawa, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Nakano, Y; Suzuki, A T; Takeuchi, Y; Yano, T; Cao, S V; Hayashino, T; Hiraki, T; Hirota, S; Huang, K; Ieki, K; Jiang, M; Kikawa, T; Minamino, A; Murakami, A; Nakaya, T; Patel, N D; Suzuki, K; Takahashi, S; Wendell, R A; Fukuda, Y; Itow, Y; Mitsuka, G; Muto, F; Suzuki, T; Mijakowski, P; Frankiewicz, K; Hignight, J; Imber, J; Jung, C K; Li, X; Palomino, J L; Santucci, G; Taylor, I; Vilela, C; Wilking, M J; Yanagisawa, C; Fukuda, D; Ishino, H; Kayano, T; Kibayashi, A; Koshio, Y; Mori, T; Sakuda, M; Takeuchi, J; Yamaguchi, R; Kuno, Y; Tacik, R; Kim, S B; Okazawa, H; Choi, Y; Ito, K; Nishijima, K; Koshiba, M; Totsuka, Y; Suda, Y; Yokoyama, M; Nantais, C M; Martin, J F; de Perio, P; Tanaka, H A; Konaka, A; Chen, S; Sui, H; Wan, L; Yang, Z; Zhang, H; Zhang, Y; Connolly, K; Dziomba, M; Wilkes, R J

    2016-01-01

    Upgraded electronics, improved water system dynamics, better calibration and analysis techniques allowed Super-Kamiokande-IV to clearly observe very low-energy 8B solar neutrino interactions, with recoil electron kinetic energies as low as 3.49 MeV. Super-Kamiokande-IV data-taking began in September of 2008; this paper includes data until February 2014, a total livetime of 1664 days. The measured solar neutrino flux is (2.308+-0.020(stat.) + 0.039-0.040(syst.)) x 106/(cm2sec) assuming no oscillations. The observed recoil electron energy spectrum is consistent with no distortions due to neutrino oscillations. An extended maximum likelihood fit to the amplitude of the expected solar zenith angle variation of the neutrino-electron elastic scattering rate in SK-IV results in a day/night asymmetry of (-3.6+-1.6(stat.)+-0.6(syst.))%. The SK-IV solar neutrino data determine the solar mixing angle as sin2 theta_12 = 0.327+0.026-0.031, all SK solar data (SK-I, SK-II, SK III and SKIV) measures this angle to be sin2 the...

  10. Lamstatin - a novel inhibitor of lymphangiogenesis derived from collagen IV

    Weckmann, Markus; Moir, Lyn Margaret; Heckman, Caroline Akemi; Black, Judith Lee; Oliver, Brian Gregory; Burgess, Janette Kay

    2012-01-01

    The lymphatic system is essential for the maintenance of tissue homeostasis and immunity. Its dysfunction in disease (such as lymphangioleiomyomatosis) can lead to chylous effusions, oedema or dissemination of malignant cells. Collagen IV has six a chains, of which some of the non-collagenous-1 doma

  11. 76 FR 36095 - Defense Transportation Regulation, Part IV

    2011-06-21

    ... ID: DOD-2010- OS-0034, published April 1, 2010 (75 FR 16445-16446). DOD has completed their review... III Domestic Small Shipments (dS2) and Nontemporary Storage (NTS) draft business rules. Responses can.../part-iv/phaseiii.cfm . All identified changes have been incorporated into the final dS2 and...

  12. 顶级体验 NIKE TIEMPO LEGEND IV ELITE

    Sexxxxxy

    2011-01-01

    NIKE(耐克)在7月1日推出了LEGEND系列的最新战靴TIEMPO LEGEND IV ELITE,这款首创了真皮加飞线鞋面的足球鞋拥有怎样的性能表现,一直是我们非常想了解的。

  13. 25 CFR 36.13 - Standard IV-Curriculum development.

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Standard IV-Curriculum development. 36.13 Section 36.13... § 36.13 Standard IV—Curriculum development. (a) Each school shall implement an organized program of curriculum development involving certified and non-certified staff and shall provide the opportunity...

  14. WAIS-IV Subtest Covariance Structure: Conceptual and Statistical Considerations

    Ward, L. Charles; Bergman, Maria A.; Hebert, Katina R.

    2012-01-01

    D. Wechsler (2008b) reported confirmatory factor analyses (CFAs) with standardization data (ages 16-69 years) for 10 core and 5 supplemental subtests from the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV). Analyses of the 15 subtests supported 4 hypothesized oblique factors (Verbal Comprehension, Working Memory, Perceptual Reasoning,…

  15. Discrepancy Score Reliabilities in the WAIS-IV Standardization Sample

    Glass, Laura A.; Ryan, Joseph J.; Charter, Richard A.

    2010-01-01

    In the present investigation, the authors provide internal consistency reliabilities for Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) subtest and Index discrepancy scores using the standardization sample as the data source. Reliabilities ranged from 0.55 to 0.88 for subtest discrepancy scores and 0.80 to 0.91 for Index discrepancy…

  16. WAIS-IV profile of cognition in schizophrenia.

    Michel, Natalie M; Goldberg, Joel O; Heinrichs, R Walter; Miles, Ashley A; Ammari, Narmeen; McDermid Vaz, Stephanie

    2013-08-01

    The Wechsler Adult Intelligence Scale (WAIS) has been used extensively to study impairment across a range of cognitive domains in schizophrenia. However, cognitive performance among those with the illness has yet to be examined using the newest edition of this measure. Hence, the current study aims first, to provide WAIS-IV normative data for Canadian individuals with schizophrenia of low average intelligence; second, to examine schizophrenia performance on all WAIS-IV subtest, index and general intelligence scores relative to healthy comparison subjects; and third, to revalidate the pattern of impairment identified in this clinical group using the WAIS-III, where processing speed (PS) was most affected, followed by working memory (WM), perceptual reasoning (PR) and verbal comprehension (VC). The WAIS-IV was administered to outpatients with schizophrenia and their performance compared with age, gender, and education matched controls. WAIS-IV schizophrenia performance data are provided. Analyses revealed significant impairment on several tasks, including the new Cancellation subtest and the VC supplemental subtest, Comprehension. At the index score level, group differences in PS were significantly larger than those observed in all other cognitive domains. Impairments were also observed in WM amid relatively preserved performance in VC, thereby confirming the pattern of impairment identified using the WAIS-III.

  17. Tetrakis(bis(trimethylsilyl)amido)uranium(IV): synthesis and reactivity.

    Lewis, Andrew J; Williams, Ursula J; Carroll, Patrick J; Schelter, Eric J

    2013-07-01

    The synthesis of the sterically saturated uranium(IV) complex U[N(SiMe3)2]4 (1) is demonstrated from the one-electron oxidation of U[N(SiMe3)2]3 with a variety of oxidants in THF. A high yielding synthesis of 1 directly from UI3(THF)4 is provided.

  18. Archaeal type IV pili and their involvement in biofilm formation.

    Pohlschroder, Mechthild; Esquivel, Rianne N

    2015-01-01

    Type IV pili are ancient proteinaceous structures present on the cell surface of species in nearly all bacterial and archaeal phyla. These filaments, which are required for a diverse array of important cellular processes, are assembled employing a conserved set of core components. While type IV pilins, the structural subunits of pili, share little sequence homology, their signal peptides are structurally conserved allowing for in silico prediction. Recently, in vivo studies in model archaea representing the euryarchaeal and crenarchaeal kingdoms confirmed that several of these pilins are incorporated into type IV adhesion pili. In addition to facilitating surface adhesion, these in vivo studies also showed that several predicted pilins are required for additional functions that are critical to biofilm formation. Examples include the subunits of Sulfolobus acidocaldarius Ups pili, which are induced by exposure to UV light and promote cell aggregation and conjugation, and a subset of the Haloferax volcanii adhesion pilins, which play a critical role in microcolony formation while other pilins inhibit this process. The recent discovery of novel pilin functions such as the ability of haloarchaeal adhesion pilins to regulate swimming motility may point to novel regulatory pathways conserved across prokaryotic domains. In this review, we will discuss recent advances in our understanding of the functional roles played by archaeal type IV adhesion pili and their subunits, with particular emphasis on their involvement in biofilm formation.

  19. Nascent transcription affected by RNA polymerase IV in Zea mays.

    Erhard, Karl F; Talbot, Joy-El R B; Deans, Natalie C; McClish, Allison E; Hollick, Jay B

    2015-04-01

    All eukaryotes use three DNA-dependent RNA polymerases (RNAPs) to create cellular RNAs from DNA templates. Plants have additional RNAPs related to Pol II, but their evolutionary role(s) remain largely unknown. Zea mays (maize) RNA polymerase D1 (RPD1), the largest subunit of RNA polymerase IV (Pol IV), is required for normal plant development, paramutation, transcriptional repression of certain transposable elements (TEs), and transcriptional regulation of specific alleles. Here, we define the nascent transcriptomes of rpd1 mutant and wild-type (WT) seedlings using global run-on sequencing (GRO-seq) to identify the broader targets of RPD1-based regulation. Comparisons of WT and rpd1 mutant GRO-seq profiles indicate that Pol IV globally affects transcription at both transcriptional start sites and immediately downstream of polyadenylation addition sites. We found no evidence of divergent transcription from gene promoters as seen in mammalian GRO-seq profiles. Statistical comparisons identify genes and TEs whose transcription is affected by RPD1. Most examples of significant increases in genic antisense transcription appear to be initiated by 3'-proximal long terminal repeat retrotransposons. These results indicate that maize Pol IV specifies Pol II-based transcriptional regulation for specific regions of the maize genome including genes having developmental significance.

  20. 76 FR 31327 - Draft National Coastal Condition Report IV

    2011-05-31

    ... Oceanic and Atmospheric Administration (NOAA) and the U.S. Fish and Wildlife Services (USFWS), and coastal... conterminous U.S., Alaska, Hawaii, and Puerto Rico. The NCCR IV data were collected from 3,144 sites from 2003... West Coast) and comparisons of these waters with near-shore condition, trends in regional...

  1. Transient C IV Broad Absorption Lines in radio detected QSOs

    Vivek, M; Gupta, N

    2015-01-01

    We study the transient (i.e. emerging or disappearing) C IV broad absorption line (BAL) components in 50 radio detected QSOs using multi-epoch spectra available in Sloan Digital Sky Survey DR10. We report the detectionof 6 BALQSOs having at least one distinct transient C IV absorption component. Based on the structure function analysis of optical light curves, we suggest that the transient absorption is unlikely to be triggered by continuum variations. Transient absorption components usually have low C IV equivalent widths ( 10000 \\kms) and typically occur over rest-frame timescales > 800 days. The detection rate of transient C IV absorption seen in our sample is higher than that reported in the literature. Using a control sample of QSOs, we show that this difference is most likely due to the longer monitoring time-scale of sources in our sample while the effect of small number statistics cannot be ignored. Thus, in order to establish the role played by radio jets in driving the BAL outflows, we need a larger...

  2. Rhenium(IV) compounds inducing apoptosis in cancer cells.

    Martínez-Lillo, José; Mastropietro, Teresa F; Lappano, Rosamaria; Madeo, Antonio; Alberto, Marta E; Russo, Nino; Maggiolini, Marcello; De Munno, Giovanni

    2011-05-14

    The anticancer properties of a series of mononuclear Re(IV) compounds of formula ReCl(4)L (where L is bpy = 2,2'-bipyridine; bpym = 2,2'-bipyrimidine; dmbpy = 4,4'-dimethyl-2,2'-bipyridine; phen = 1,10-phenanthroline) were investigated for the first time. All compounds displayed potent in vitro antiproliferative activity against selected cancer cells.

  3. Rorschach correlates of the DSM-IV histrionic personality disorder.

    Blais, M A; Hilsenroth, M J; Fowler, J C

    1998-04-01

    Rorschach assessment data have long been rationally linked to the psychiatric condition of hysteria. This study represents the first empirical attempt to explore the associations among select Rorschach variables, the Diagnostic and Statistical Manual of Mental Disorders (4th ed. [DSM-IV]; American Psychiatric Association, 1994) Histrionic Personality Disorder (HPD) criteria, and two self-report measures of hysteria. We correlated four Rorschach variables with total symptom scores for DSM-IV Cluster B Personality Disorders (Borderline, Antisocial, Narcissistic, and Histrionic). We found two Rorschach variables, FC + CF + C and T (Exner, 1993), to be significantly and meaningfully correlated with both the DSM-IV HPD total score (number of criteria) and the individual HPD criteria. Although not significantly associated with the HPD total score, Denial (DEN; Lerner & Lerner, 1980) was associated with one individual HPD criterion. Furthermore, DEN was significantly correlated with the MMPI-2 Hysteria (Hy) scale. The results are reviewed in terms of their clinical utility and the insights they offer into the psychological characteristics of the DSM-IV HPD.

  4. Psychodiagnosis for Counselors: The DSM-IV. ERIC Digest.

    Hinkle, J. Scott

    This digest notes that there has been an increase in the number of graduate community mental health counseling programs requiring course work in abnormal behavior, psychopathology, and psychodiagnosis and that, as a result of this increase, utilization of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) also has…

  5. Clinical Utility of Cancellation on the WISC-IV

    Zhu, Jianjun; Chen, Hsinyi

    2013-01-01

    This study examined empirical evidence for clinical utility of the Wechsler Intelligence Scale for Children, fourth edition (WISC-IV) cancellation subtest by comparing data from 597 clinical and 597 matched control children. The results of dependent t and sequential logistic regression analyses demonstrated that (a) children with intellectual…

  6. Study of the cerium(IV)-picrate system in acetonitrile.

    Kratochvil, B; Tipler, M; McKay, B

    1966-07-01

    A potentiometric and spectrophotometric study has been made of the reaction between hexanitratocerate and picrate in dry acetonitrile. Several cerium(IV)-picrate complexes are formed; the formation constant for the first is estimated to be 4 from spectrophotometric measurements. The catalytic effect of picrate on hydroquinone oxidation by nitratocerate is postulated to be due to more rapid electron transfer by cerium picrate complexes.

  7. Deconstructing the DSM-IV-TR: a critical perspective.

    Warelow, Philip; Holmes, Colin A

    2011-12-01

    This paper examines and offers a critique of the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR), underlying principles and assumptions, and the nature and consequences of its nosological framework. The reason for this critique is to look at the rationale for some of the diagnostic categories and also why some categories are retained, including some of the long-standing diagnostic groups, such as schizophrenia. It is not the intention here to rehearse the problems of biological psychiatric thinking, nor argue the strengths and weaknesses of the DSM-IV-TR in its definitions and descriptions of particular syndromes and illnesses. The ideas presented here derive from a range of previous research that argued that the DSM-IV-TR colludes in a system of psychiatric care in which all people, by virtue of characteristically human foibles and idiosyncrasies, are potentially classifiable into a variety of diagnostic mental health categories. In the present study, it was argued that because of resource constraints, professional dispute, and public concern, the major criterion for attracting a formal diagnosis is not classifiability according to the DSM-IV-TR, but rather, that of 'social risk', defined in terms of risk to oneself and/or others and embodying obvious social control functions. Here, we expand and develop some of these ideas, and relate them more specifically to insights offered by critical or deconstructive psychology and the development of the forthcoming the DSM-V.

  8. Sargent-IV Project. Development of new methodologies for safety analysis of Generation IV reactors; Proyecto SARGEB-IV. Desarrollo de nuevas metodologias de analisis de seguridad para reactores de Generacion IV

    Queral, C.; Gallego, E.; Jimenez, G.

    2013-07-01

    The main result of this paper is the proposal for the addition of new ingredients in the safety analysis methodologies for Generation-IV reactors that integrates the features of probabilistic safety analysis within deterministic. This ensures a higher degree of integration between the classical deterministic and probabilistic methodologies.

  9. Parameter extraction from I-V characteristics of PV devices

    Macabebe, Erees Queen B. [Department of Electronics, Computer and Communications Engineering, Ateneo de Manila University, Loyola Heights, Quezon City 1108 (Philippines); Department of Physics and Centre for Energy Research, Nelson Mandela Metropolitan University, PO Box 77000, Port Elizabeth 6031 (South Africa); Sheppard, Charles J. [Department of Physics, University of Johannesburg, PO Box 524, Auckland Park 2006 (South Africa); Dyk, E. Ernest van [Department of Physics and Centre for Energy Research, Nelson Mandela Metropolitan University, PO Box 77000, Port Elizabeth 6031 (South Africa)

    2011-01-15

    Device parameters such as series and shunt resistances, saturation current and diode ideality factor influence the behaviour of the current-voltage (I-V) characteristics of solar cells and photovoltaic modules. It is necessary to determine these parameters since performance parameters are derived from the I-V curve and information provided by the device parameters are useful in analyzing performance losses. This contribution presents device parameters of CuIn(Se,S){sub 2}- and Cu(In,Ga)(Se,S){sub 2}-based solar cells, as well as, CuInSe{sub 2}, mono- and multicrystalline silicon modules determined using a parameter extraction routine that employs Particle Swarm Optimization. The device parameters of the CuIn(Se,S){sub 2}- and Cu(In,Ga)(Se,S){sub 2}-based solar cells show that the contribution of recombination mechanisms exhibited by high saturation current when coupled with the effects of parasitic resistances result in lower maximum power and conversion efficiency. Device parameters of photovoltaic modules extracted from I-V characteristics obtained at higher temperature show increased saturation current. The extracted values also reflect the adverse effect of temperature on parasitic resistances. The parameters extracted from I-V curves offer an understanding of the different mechanisms involved in the operation of the devices. The parameter extraction routine utilized in this study is a useful tool in determining the device parameters which reveal the mechanisms affecting device performance. (author)

  10. A FORTRAN IV Program for Scoring Written Simulations

    Bligh, Thomas J.; Noe, Michael J.

    1977-01-01

    A computer program for scoring written simulation tests provides individual scores and basic item analysis data. The program is written in Fortran IV and can accomodate up to thirty-five hundred options and up to ten thousand examinees. (Author/JKS)

  11. Counsellors Respond to the DSM-IV-TR

    Strong, Tom; Gaete, Joaquin; Sametband, Ines N.; French, Jared; Eeson, Jen

    2012-01-01

    The Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) is an administrative fact for many counsellors. This psychiatric approach to formulating client concerns runs counter to those used by counsellors of many approaches (e.g., systemic, feminist). Using an online survey of counsellors (N = 116), invited contributions to a website…

  12. Liquid Propellant Blast Yields for Delta IV Heavy Vehicles

    2010-07-01

    exterior shells shown in a layered construction. Unfortunately, the 3D model is too computationally intensive to run on a PC, and may even be too large to...Research Triangle Institute, Cocoa Beach, FL, 30 July 2004. LIQUID PROPELLANT BLAST YIELDS FOR DELTA IV HEAVY VEHICLES Ron R. Lambert ACTA Lompoc, CA

  13. Gérard Genette : a escrita de Figures IV

    2012-01-01

    This article reflects on Genette's most recent work and his theorisation on his own work (its unity and heterogeneity) and the recent multiplication of the areas of study (from music to painting, from Stendhal to Proust). Note is also made of Genette's idiosyncrasy in Figures IV.

  14. Characterization of human and mouse peroxiredoxin IV: evidence for inhibition by Prx-IV of epidermal growth factor- and p53-induced reactive oxygen species.

    Wong, C M; Chun, A C; Kok, K H; Zhou, Y; Fung, P C; Kung, H F; Jeang, K T; Jin, D Y

    2000-01-01

    The aim of this study was to identify and characterize human and mouse Prx-IV. We identified mouse peroxiredoxin IV (Prx-IV) by virtue of sequence homology to its human ortholog previously called AOE372. Mouse Prx-IV conserves an amino-terminal presequence coding for signal peptide. The amino acid sequences of mature mouse and human Prx-IV share 97.5% identity. Phylogenetic analysis demonstrates that Prx-IV is more closely related to Prx-I/-II/-III than to Prx-V/-VI. Previously, we mapped the mouse Prx-IV gene to chromosome X by analyzing two sets of multiloci genetic crosses. Here we performed further comparative analysis of mouse and human Prx-IV genomic loci. Consistent with the mouse results, human Prx-IV gene localized to chromosome Xp22.135-136, in close proximity to SAT and DXS7178. A bacterial artificial chromosome (BAC) clone containing the complete human Prx-IV locus was identified. The size of 7 exons and the sequences of the splice junctions were confirmed by PCR analysis. We conclude that mouse Prx-IV is abundantly expressed in many tissues. However, we could not detect Prx-IV in the conditioned media of NIH-3T3 and Jurkat cells. Mouse Prx-IV was specifically found in the nucleus-excluded region of cultured mouse cells. Intracellularly, overexpression of mouse Prx-IV prevented the production of reactive oxygen species induced by epidermal growth factor or p53. Taken together, mouse Prx-IV is likely a cytoplasmic or organellar peroxiredoxin involved in intracellular redox signaling.

  15. The SDSS-IV in 2014: A Demographic Snapshot

    Lundgren, Britt; Kinemuchi, Karen; Zasowski, Gail; Lucatello, Sara; Diamond-Stanic, Aleksandar M.; Tremonti, Christy A.; Myers, Adam D.; Aragón-Salamanca, Alfonso; Gillespie, Bruce; Ho, Shirley; Gallagher, John S.

    2015-08-01

    Many astronomers now participate in large international scientific collaborations, and it is important to examine whether these structures foster a healthy scientific climate that is inclusive and diverse. The Committee on the Participation of Women in the Sloan Digital Sky Survey (CPWS) was formed to evaluate the demographics and gender climate within SDSS-IV, one of the largest and most geographically distributed astronomical collaborations. In 2014 April, the CPWS administered a voluntary demographic survey to establish a baseline for the incipient SDSS-IV, which began observations in 2014 July. We received responses from 250 participants (46% of the active membership). Half of the survey respondents were located in the United States or Canada and 30% were based in Europe. Approximately 65% were faculty or research scientists and 31% were postdocs or graduate students. Eleven percent of survey respondents considered themselves to be an ethnic minority at their current institution. Twenty-five percent of the SDSS-IV collaboration members are women, a fraction that is consistent with the U.S. astronomical community, but substantially higher than the fraction of women in the International Astronomical Union (16%). Approximately equal fractions of men and women report holding positions of leadership in the collaboration. When binned by academic age and career level, men and women also assume leadership roles at approximately equal rates, in a way that increases steadily for both genders with increasing seniority. In this sense, SDSS-IV has been successful in recruiting leaders that are representative of the collaboration. That said, it is clear that more progress needs to be made toward achieving gender balance and increasing diversity in the field of astronomy, and there is still room for improvement in the membership and leadership of SDSS-IV. For example, at the highest level of SDSS-IV leadership, women disproportionately assume roles related to education and

  16. Biological role of prolyl 3-hydroxylation in type IV collagen.

    Pokidysheva, Elena; Boudko, Sergei; Vranka, Janice; Zientek, Keith; Maddox, Kerry; Moser, Markus; Fässler, Reinhard; Ware, Jerry; Bächinger, Hans Peter

    2014-01-07

    Collagens constitute nearly 30% of all proteins in our body. Type IV collagen is a major and crucial component of basement membranes. Collagen chains undergo several posttranslational modifications that are indispensable for proper collagen function. One of these modifications, prolyl 3-hydroxylation, is accomplished by a family of prolyl 3-hydroxylases (P3H1, P3H2, and P3H3). The present study shows that P3H2-null mice are embryonic-lethal by embryonic day 8.5. The mechanism of the unexpectedly early lethality involves the interaction of non-3-hydroxylated embryonic type IV collagen with the maternal platelet-specific glycoprotein VI (GPVI). This interaction results in maternal platelet aggregation, thrombosis of the maternal blood, and death of the embryo. The phenotype is completely rescued by producing double KOs of P3H2 and GPVI. Double nulls are viable and fertile. Under normal conditions, subendothelial collagens bear the GPVI-binding sites that initiate platelet aggregation upon blood exposure during injuries. In type IV collagen, these sites are normally 3-hydroxylated. Thus, prolyl 3-hydroxylation of type IV collagen has an important function preventing maternal platelet aggregation in response to the early developing embryo. A unique link between blood coagulation and the ECM is established. The newly described mechanism may elucidate some unexplained fetal losses in humans, where thrombosis is often observed at the maternal/fetal interface. Moreover, epigenetic silencing of P3H2 in breast cancers implies that the interaction between GPVI and non-3-hydroxylated type IV collagen might also play a role in the progression of malignant tumors and metastasis.

  17. Archaeal type IV pili and their involvement in biofilm formation

    Rianne eEsquivel

    2015-03-01

    Full Text Available Type IV pili are ancient proteinaceous structures present on the cell surface of species in nearly all bacterial and archaeal phyla. These filaments are involved in a diverse array of critical cellular processes. While the core components of the pilus biosynthesis machinery are highly conserved, type IV pilins, the structural subunits of pili, share little sequence homology. However, the conserved structure of the signal peptides of these pilus subunits has allowed the development of prediction programs that accurately detect the processing sites recognized by bacterial and archaeal prepilin peptidases. Using these programs, the genomes of organisms from both prokaryotic domains have been shown to encode a diverse set of putative type IV pilins. Recently, in vivo studies in model archaea representing the euryarchaeal and crenarchaeal kingdoms confirmed that several of these pilins are incorporated into type IV adhesion pili. In addition to facilitating surface adhesion, these in vivo studies also showed that several predicted pilins are required for additional functions that are critical to biofilm formation. Examples include the subunits of Sulfolobus acidocaldarius Ups pili, which are induced by exposure to UV light and promote cell aggregation and conjugation, and a subset of the Haloferax volcanii adhesion pilins, which play a critical role in microcolony formation while other pilins inhibit this process. The recent discovery of novel pilin functions such as the ability of haloarchaeal adhesion pilins to regulate swimming motility rather than being unique to organisms that inhabit high salt environments may point to novel prokaryotic regulatory pathways. In this review, we will discuss recent advances in our understanding of the functional roles played by archaeal type IV adhesion pili and their subunits, with particular emphasis on their involvement in biofilm formation.

  18. Reduced serum dipeptidyl peptidase-IV after metformin and pioglitazone treatments.

    Lenhard, James M; Croom, Dallas K; Minnick, Dana T

    2004-11-05

    Dipeptidyl peptidase-IV (DPP-IV) regulates metabolism by degrading incretins involved in nutritional regulation. Metformin and pioglitazone improve insulin sensitivity whereas glyburide promotes insulin secretion. Zucker diabetic rats were treated with these antidiabetic agents for 2 weeks and DPP-IV activity and expression were determined. Serum DPP-IV activity increased whereas tissue activity decreased as the rats aged. Treatment of rats with metformin, pioglitazone, and glyburide did not alter DPP-IV mRNA expression in liver or kidney. Metformin and pioglitazone significantly (PMetformin, pioglitazone, and glyburide had no effect on serum DPP-IV activity in vitro, indicating these are not competitive DPP-IV inhibitors. We propose the in vivo inhibitory effects observed with metformin and pioglitazone on serum DPP-IV activity results from reduced DPP-IV secretion.

  19. COMPARATIVE STUDY OF ATTENUATION OF CARDIOVASCULAR RESPONSE TO LARYNGOSCOPY AND INTUBATION WITH IV DEXMEDETOMIDINE VS. IV LIGNOCAINE

    Shiva

    2016-03-01

    Full Text Available Endotracheal intubation is one of the most commonly performed procedures, where the role of the anaesthesiologists in patient care is noteworthy. Endotracheal intubation is translaryngeal placement of endotracheal tube into the trachea via the nose or mouth. General anaesthesia procedures involve stressful events at various stages. The most stressful situations are seen during the period of induction, intubation and extubation. A 25% to 50% increase in mean arterial pressure and heart rate is seen during induction followed by laryngoscopy and intubation peaking at 1-2 minutes and returning to baseline within 10-15 minutes. AIMS AND OBJECTIVES A comparative study of attenuation of cardiovascular response to laryngoscopy and intubation with IV dexmedetomidine vs IV lignocaine, to compare changes in HR, systolic blood pressure (SBP, diastolic blood pressure (DBP and mean arterial pressure (MAP in patients premedicated with dexmedetomidine and lidocaine and to observe for any significant difference in the anaesthetic requirement and intraoperative complications if any in both the groups. METHODOLOGY A total of 60 patients undergoing elective surgeries were selected. Group D consists of 30 patients, who received IV dexmedetomidine loading dose, 1 mcg/kg diluted in 50 mL NS for 10 minutes prior to laryngoscopy. Group –L consists of 30 patients who received plain preservative-free Lidocaine 2%, 1.5 mg/kg body weight IV bolus ninety seconds prior to laryngoscopy. RESULTS Dexmedetomidine in a bolus dose of 1 ug/kg IV attenuates heart rate response to laryngoscopy and intubation effectively than plain preservative-free lignocaine. The basal values of heart rate were reached within 1 min after intubation in case of dexmedetomidine group. Dexmedetomidine blunts the increase in systolic, diastolic and mean arterial pressure effectively than Plain preservative-free Lignocaine.

  20. Metallicity of the Intergalactic Medium Using Pixel Statistics. IV. Oxygen

    Aguirre, Anthony; Dow-Hygelund, Corey; Schaye, Joop; Theuns, Tom

    2008-12-01

    We have studied the abundance of oxygen in the IGM by analyzing O VI, C IV, Si IV, and H I pixel optical depths derived from a set of high-quality VLT and Keck spectra of 17 QSOs at 2.1lesssim zlesssim 3.6. Comparing ratios τO VI/τC IV(τC IV) to those in realistic, synthetic spectra drawn from a hydrodynamical simulation and comparing to existing constraints on [Si/C] places strong constraints on the ultraviolet background (UVB) model using weak priors on allowed values of [Si/O]: for example, a quasar-only background yields [ Si/O ] ≈ 1.4, which is highly inconsistent with the [ Si/O ] ≈ 0 expected from nucleosynthetic yields and with observations of metal-poor stars. Assuming a fiducial quasar+galaxy UVB consistent with these constraints yields a primary result that [ O/C ] = 0.66 +/- 0.06 +/- 0.2; this result pertains to gas with overdensity δ gtrsim 2. Consistent results are obtained by similarly comparing τO VI/τH I(τH I) and τO VI/τSi IV(τSi IV) to simulation values, and also by directly ionization-correcting τO VI/τH I as a function of τH I into [O/H] as a function of density. Subdividing the sample reveals no evidence for evolution, but low- and high-τH I samples are inconsistent, suggesting either density dependence of [O/C] or—more likely—prevalence of collisionally ionized gas at high density. Based on public data obtained from the ESP archive of observations from the UVES spectrograph at the VLT, Paranal, Chile, and on data obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. The W. M. Keck Observatory was made possible by the generous financial support of the W. M. Keck Foundation.

  1. Outcome of surgical treatment of type IV capitellum frac-

    Singh Ajay Pal

    2012-08-01

    Full Text Available 【Abstract】 Objective: Fractures of the capitellum and trochlea constitute less than 1% of all elbow fractures and a shear fracture involving the capitellum and extending medially into most of the trochlea is rarely reported. Type IV capitellum fracture is still controversial in regard to its ra-diographic appearance, surgical approach and osteosynthesis. We report 10 cases of type IV capitellum fracture with a view to elucidating its clinical features and treatment outcome. Methods: We treated 10 patients of type IV capitellum fracture with a mean age of 32 years. A uniform surgical approach and postoperative rehabilitation were followed. Results: Nine patients presented to us after a mean of 4 days of injury and one patient was nonunion after 6 months of injury who had been treated conservatively by a bone setter. Double arc sign was absent in 6 cases. Intraopera-tively 6 capitellotrochlear fragments were devoid of soft Chin J Traumatol 2012;15(4:201-205 DOI: 10.3760/cma.j.issn.1008-1275.2012.04.002 Punjab Civil Medical Services-I Mukerian, Punjab, In-dia (Singh AP Department of Orthopaedics, UCMS & GTB Hospital, Delhi, India (Dhammi IK and Garg V Swami Premanand Hospital, Mukerian, Punjab, India (Singh AP *Corresponding author: Tel: 98-72069734, Email: docajaypal@gmail.com C oronal shear fractures of distal end of humeral articular surface involve the capitellum and trochlea. These fractures are difficult to assess accurately on plain radiographs and the limited amount of subchondral bone available for stable internal fixation makes the operative treatment equally difficult. 1 Joint stiffness, instability and osteoarthrosis are complications resulting from treatment failures. 2 The major classification systems are proposed by Bryan and Dubberley et al. 3,4 Type IV fracture is a fracture involving the capitellum and extends to more than lateral half of the trochlea. 1 We report an analysis of ten cases of type IV capi-tissue attachments. By

  2. Functionalization of group IV semiconductors; Funktionalisierung von Gruppe IV-Halbleitern

    Hoeb, Marco Andreas

    2011-01-15

    The present work is focused on the structural and electronic properties of thermally and photochemically grafted alkene molecules. The semiconductor substrates used in this work are the group IV-semiconductors silicon, diamond, and silicon carbide. On silicon, functionalization via the commonly known hydrosilylation reaction was performed. During thermal treatment in vacuum-distilled 1-octadecene, the alkene molecules covalently added to the substrate via Si-C bond formation, resulting in self-assembled organic monolayers. The reaction resulted in smooth and homogeneous alkyl-terminated surfaces. Static water contact angles were determined to be 113 . Photoelectron spectroscopy was performed and showed no evidence of surface oxidation. The high packing of the organic layers is indicated by the asymmetric methylene vibrational mode, which has been redshifted by -4 cm{sup -1} with respect to the liquid alkene mode position. The average molecular tilt-angle of the alkyl-molecules, relative to the surface normal, has been identified to be 34 . The transport properties have been determined to be dominated by tunneling processes. On diamond, first results on the thermal functionalization of hydrogen- and oxygen-terminated surfaces are demonstrated. Thermal functionalization with octadecene showed high selectivity, while hydrogenated diamond surfaces were found to be inert to the thermally induced reaction with alkenes. In contrast, alkene molecules were successfully grafted to oxygen-terminated sites via covalent C-O-C bonds. Reaction temperatures as high as 160 C were necessary to initiate the functionalization process.Wetting experiments on the alkyl-modified surfaces revealed contact angle values of 103 . The high quality of the monolayers on oxygenated surfaces was confirmed by IR-spectroscopy. In addition, polarized IR-measurements indicated a tilt angle of 23 . On silicon carbide, thermal and UV-induced alkoxylation were studied. Hydrofluoric acid treatment

  3. Association of systemic collagen type IV formation with survival among patients undergoing hemodialysis

    Leeming, Diana Julie; Karsdal, Morten A; Rasmussen, Lars M;

    2013-01-01

    The 7S domain of collagen type IV (P4NP_7S) assessed in plasma represents systemic collagen type IV formation. The objective of the study was to investigate the association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.......The 7S domain of collagen type IV (P4NP_7S) assessed in plasma represents systemic collagen type IV formation. The objective of the study was to investigate the association of systemic collagen type IV formation with survival among patients undergoing hemodialysis....

  4. Lasing Towards the VUV in the NIJI-IV FEL

    Yamada, K; Ohgaki, H; Mikado, T; Sugiyama, S; Yamazaki, T

    2000-01-01

    The lasing wavelength in the NIJI-IV free electron laser (FEL) reached 212 nm in the deep ultraviolet (UV) range. Adoption of Al sub 2 O sub 3 /SiO sub 2 multilayer mirrors to the laser cavity, whose light absorption loss is sufficiently small even below 220 nm, compared with HfO sub 2 /SiO sub 2 usually used in the UV, was essential to shorten the wavelength in the deep UV range. The laser gain was estimated to be approx 2% around 214 nm with a peak beam current of approx 4A (average beam current of approx 20 mA) from the measured loss of the cavity degraded after the lasing experiments which agreed well with an analytic gain calculation. Lasing in the vacuum ultraviolet (VUV) range is also expected even on the compact storage ring NIJI-IV with possible enhancement of the laser gain.

  5. DSM-5 personality traits and DSM-IV personality disorders.

    Hopwood, Christopher J; Thomas, Katherine M; Markon, Kristian E; Wright, Aidan G C; Krueger, Robert F

    2012-05-01

    Two issues pertinent to the Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) proposal for personality pathology, the recovery of DSM-IV personality disorders (PDs) by proposed DSM-5 traits and the validity of the proposed DSM-5 hybrid model, which incorporates both personality pathology symptoms and maladaptive traits, were evaluated in a large undergraduate sample (N = 808). Proposed DSM-5 traits as assessed with the Personality Inventory for DSM-5 explained a substantial proportion of variance in DSM-IV PDs as assessed with the Personality Diagnostic Questionnaire-4+, and trait indicators of the 6 proposed DSM-5 PDs were mostly specific to those disorders with some exceptions. Regression analyses support the DSM-5 hybrid model in that pathological traits, and an indicator of general personality pathology severity provided incremental information about PDs. Findings are discussed in the context of broader issues around the proposed DSM-5 model of personality disorders.

  6. Band gap scaling laws in group IV nanotubes

    Wang, Chongze; Fu, Xiaonan; Guo, Yangyang; Guo, Zhengxiao; Xia, Congxin; Jia, Yu

    2017-03-01

    By using the first-principles calculations, the band gap properties of nanotubes formed by group IV elements have been investigated systemically. Our results reveal that for armchair nanotubes, the energy gaps at K points in the Brillouin zone decrease as 1/r scaling law with the radii (r) increasing, while they are scaled by ‑1/r 2 + C at Γ points, here, C is a constant. Further studies show that such scaling law of K points is independent of both the chiral vector and the type of elements. Therefore, the band gaps of nanotubes for a given radius can be determined by these scaling laws easily. Interestingly, we also predict the existence of indirect band gap for both germanium and tin nanotubes. Our new findings provide an efficient way to determine the band gaps of group IV element nanotubes by knowing the radii, as well as to facilitate the design of functional nanodevices.

  7. Structural and Electronic Properties of IV-VI Semiconductor Nanodots

    Leitsmann, Roman; Bechstedt, Friedhelm

    2008-03-01

    The characterization of nanostructure properties versus dimension and surface passivation is of increasing importance for the nanotechnology. Especially the stoichiometry, geometry, and the electronic states of IV-VI semiconductor nanodots are of special interest [1,2]. We use ab initio methods to calculate structural and electronic properties of colloidal IV-VI semiconductor nanodots as a function of the dot diameter. A method to passivate the non-directional dangling bonds at the nanodot surfaces is derived and used to study the confinement effect on the HOMO (highest occupied molecular orbital) and LUMO (lowest unoccupied molecular orbital) states. In addition we take the influence of relativistic (spin-orbit coupling -- SOC ) and excitonic effects into account. While the SOC leads to a considerable decrease of the HOMO-LUMO gap, excitonic effects play a minor role. [1] JACS 128, 10337 (2006) [2] JACS 129, 11354 (2007)

  8. The Synthesis, Characterization and Comparative Anticorrosion Study of Some Organotin(IV 4-Chlorobenzoates

    Hastin Kurniasih

    2015-12-01

    Full Text Available The synthesis of 3 compounds of a series of dibutyl(IV di-4-chlorobenzoate, diphenyl(IV di-4-chlorobenzoate and triphenyltin(IV 4-chlorobenzoate have successfully been performed by reacting the dibutyltin(IV dichloride, diphenyltin(IV dichloride and triphenyltin(IV chloride respectively via the dibutyltin(IV oxide, diphenyltin(IV dihydroxide and triphenyltin(IV hydroxide with 4-chlorobenzoic acid. All compounds synthesized were well characterized by 1H and 13C NMR, IR and UV-Vis spectroscopies as well as based on the microanalytical data. The anticorrosion activity of these compounds were tested on Hot Roller Plate (HRP mild steel in DMSO-HCl solution using potentiodynamic method. The results revealed that the triphenyltin(IV 4-chlorobenzoate clearly showed the strongest inhibitor activity compared to the other derivatives, while diphenyltin(IV compounds were better than that of dibutyltin(IV analogous. The results reported here indicated that the optimal activity were depended on the ligand attached to the metal centre and might also be related to the number of carbon atoms present in the organotin(IV used.

  9. Selective solid-phase extraction of trace thorium(IV) using surface-grafted Th(IV)-imprinted polymers with pyrazole derivative.

    Lin, Canrong; Wang, Hongqing; Wang, Yuyuan; Cheng, Zhiqiang

    2010-04-15

    A new pyrazole derivative 1-phenyl-3-methylthio-4-cyano-5-acrylicacidcarbamoyl-pyrazole (PMTCAACP) was synthesized and chosen as a complexing monomer for the preparation of surface-grafted ion-imprinted polymers for selective solid-phase extraction of thorium(IV). The silica gel, modified with maleic anhydride, was prepared as a carrier material. In the ion-imprinting process, Th(IV) was complexed with PMTCAACP, and then imprinted in the polymers grafted to the surface of modified silica gel. Subsequently, the template Th(IV) ions were removed with 6 mol/L HCl solution. The obtained ion-imprinted particles for Th(IV) showed specific recognition, and rapid adsorption and desorption kinetics process. The maximum static and total dynamic adsorption capacity of the ion-imprinted polymers (IIPs) for Th(IV) was 64.8 and 37.4 mg/g, respectively. The relative selectivity coefficient values of the imprinted adsorbent for Th(IV)/U(VI), Th(IV)/Ce(III), Th(IV)/La(III), and Th(IV)/Zr(IV) were 72.9, 89.6, 93.8, and 137.2 times greater than non-imprinted matrix, respectively. The interference effect of common cations tested did not interfere with the recovery of Th(IV). The enhancement factor of 20.2, the detection limit of 0.43 microg/L, and the precision of 2.47% (n=7) of the method under the optimized conditions were obtained. Additionally, the calibration curve (r=0.9993) was linear in the range of 1.43-103 microg/L of thorium(IV). The prepared IIPs were shown to be promising for solid-phase extraction coupled with UV-vis spectrophotometry for determination of trace Th(IV) in real samples.

  10. Method of synthesis of anhydrous thorium(IV) complexes

    Kiplinger, Jaqueline L; Cantat, Thibault

    2013-04-30

    Method of producing anhydrous thorium(IV) tetrahalide complexes, utilizing Th(NO.sub.3).sub.4(H.sub.2O).sub.x, where x is at least 4, as a reagent; method of producing thorium-containing complexes utilizing ThCl.sub.4(DME).sub.2 as a precursor; method of producing purified ThCl.sub.4(ligand).sub.x compounds, where x is from 2 to 9; and novel compounds having the structures: ##STR00001##

  11. Synthesis and Characterization of Novel Nanocrystalline Zirconium (IV Tungstate Semiconductor

    S. Manoj

    2011-01-01

    Full Text Available Nanocrystalline zirconium (IV tungstate is prepared by chemical coprecipitation method using ethylene diamine tetra acetic acid as the templating agent. Elemental composition is determined by EDS. The characteristic bonding position is identified using FTIR. XRD is used to find the theoritical value of size and phase identification using JCPDS. Morphology is examined using SEM and HRTEM. UV absorption at 260 nm corresponds to an energy gap of 4.48 eV, characteristic of semiconducting nanoparticles.

  12. Synthesis and Characterization of Novel Nanocrystalline Zirconium (IV) Tungstate Semiconductor

    Manoj, S.; Beena, B.

    2011-01-01

    Nanocrystalline zirconium (IV) tungstate is prepared by chemical coprecipitation method using ethylene diamine tetra acetic acid as the templating agent. Elemental composition is determined by EDS. The characteristic bonding position is identified using FTIR. XRD is used to find the theoritical value of size and phase identification using JCPDS. Morphology is examined using SEM and HRTEM. UV absorption at 260 nm corresponds to an energy gap of 4.48 eV, characteristic of semiconducting nanopar...

  13. Accidental IV administration of epinephrine instead of midazolam at colonoscopy

    Ahmed Gado

    2016-03-01

    Full Text Available Drug administration errors appear to be a major source of iatrogenic harm to hospitalized patients. They often, particularly in the case of epinephrine, have catastrophic consequences both for the patient and the well-meaning provider. The following incident is a medication error case report which illustrates one way that incorrect medication may be administered. IV epinephrine was accidentally administered instead of midazolam at colonoscopy.

  14. Chile; Staff Report for the 2015 Article IV Consultation

    2015-01-01

    This 2015 Article IV Consultation highlights that the GDP growth of Chile has remained lackluster over the past year. The main force behind the economic slowdown in 2014 has been the sharp fall in private investment, mainly the consequence of the end of the mining boom, but also reflecting the uncertainty and adjustment costs associated with the structural reform agenda. The IMF staff expects growth to increase modestly to 2.5 percent in 2015, mainly thanks to strong fiscal support. Private d...

  15. Cyprus; Staff Report for the 2002 Article IV Consultation

    International Monetary Fund

    2003-01-01

    This 2002 Article IV Consultation highlights that after four years of strong growth, economic activity in Cyprus has tailed off since late 2001, affected by the global economic slowdown. The authorities estimate growth for 2002 to have declined to 2.3 percent, with falling tourist arrivals and weakening consumer and business confidence. Inflation has risen to 2.9 percent year-over-year in December on account of indirect tax increases, but core inflation remains low. The current account defici...

  16. Campylobacteremia in stage IV gliosarcoma with bevacizumab treatment

    Ping Liu

    2012-04-01

    Full Text Available Primary campylobacter enteritis with secondary bacteremia was diagnosed in an immunocompromised patient with stage IV gliosarcoma. She developed mild diarrhea followed by systemic symptoms with transient generalized weakness and fever. She was treated with azithromycin and had a full recovery and without relapse through 2 months of follow-up. Her diagnosis was confirmed by a positive stool culture for Campylobacter sp. and blood culture for Campylobacter jejuni/coli.

  17. Nonoperative management for patients with grade IV blunt hepatic trauma

    Zago Thiago

    2012-08-01

    Full Text Available Abstract Introduction The treatment of complex liver injuries remains a challenge. Nonoperative treatment for such injuries is increasingly being adopted as the initial management strategy. We reviewed our experience, at a University teaching hospital, in the nonoperative management of grade IV liver injuries with the intent to evaluate failure rates; need for angioembolization and blood transfusions; and in-hospital mortality and complications. Methods This is a retrospective analysis conducted at a single large trauma centre in Brazil. All consecutive, hemodynamically stable, blunt trauma patients with grade IV hepatic injury, between 1996 and 2011, were analyzed. Demographics and baseline characteristics were recorded. Failure of nonoperative management was defined by the need for surgical intervention. Need for angioembolization and transfusions, in-hospital death, and complications were also assessed Results Eighteen patients with grade IV hepatic injury treated nonoperatively during the study period were included. The nonoperative treatment failed in only one patient (5.5% who had refractory abdominal pain. However, no missed injuries and/or worsening of bleeding were observed during the operation. None of the patients died nor need angioembolization. No complications directly related to the liver were observed. Unrelated complications to the liver occurred in three patients (16.7%; one patient developed a tracheal stenosis (secondary to tracheal intubation; one had pleural effusion; and one developed an abscess in the pleural cavity. The hospital length of stay was on average 11.56 days. Conclusions In our experience, nonoperative management of grade IV liver injury for stable blunt trauma patients is associated with high success rates without significant complications.

  18. Synthesis, Characterization and Antimicrobial Activity of Zirconium (IV) Complexes

    Sharma, Shobhana; Jain, Asha; Saxena, Sanjiv [Univ. of Rajasthan, Jaipur (India)

    2012-08-15

    Heteroleptic complexes of zirconium (IV) derived from bulky Schiff base ligands containing a sulphur atom and oximes of heterocyclic β-diketones of the general formula ZrLL' (where L'H{sub 2}=RCNH(C{sub 6}H{sub 4})SC : C(OH)N(C{sub 6}H{sub 5})N : CCH{sub 3}, R=-C{sub 6}H{sub 5}, -C{sub 6}H{sub 4}Cl(p) and L'H{sub 2}=R'C : (NOH)C : C(OH)N(C{sub 6}H{sub 5})N : CCH{sub 3}, R' = -CH{sub 2}CH{sub 3}, -C{sub 6}H{sub 5}, -C{sub 6}H{sub 4}Cl (p) were prepared by the reactions of zirconium tetrachloride with disodium salts of Schiff bases (L Na{sub 2}) and oximes of heterocyclic β-diketones (L' Na{sub 2}) in 1:1:1 molar ratio in dry refluxing THF. The structures of these monomeric zirconium (IV) complexes were elucidated with the help of elemental analysis, molecular weight measurements, spectroscopic (IR, NMR and mass) studies. A distorted trigonal bipyramidal geometry may be suggested for these heteroleptic zirconium (IV) complexes. The ligands (bulky Schiff base ligands containing a sulphur atom and oximes of heterocyclic β-diketones) and their heteroleptic complexes of zirconium (IV) were screened against A. flavus, P. aeruginesa and E. coli.

  19. Dibutylammonium bis(hydrogen methylphosphonato-κOtriphenylstannate(IV

    Tidiane Diop

    2012-10-01

    Full Text Available The asymmetric unit of the title organotin salt, (C8H20N[Sn(C6H53(CH4O3P2], contains two dibutylammonium cations and two stannate(IV anions consisting each of two monodentately bonding methyl hydrogenphosphate groups attached to an Sn(C6H5 unit. The overall coordination environment of the two SnIV atoms is trigonal–bipyramidal defined by three phenyl C atoms in equatorial positions and two methyl hydrogenphosphate O atoms at the apical sites. In the crystal, the stannate(IV anions are linked to each other via pairs of short O—H...O hydrogen bonds, leading to an infinite chain extending parallel to the b-axis direction. Neighbouring chains are linked by N—H...O hydrogen bonds involving the butylammonium cations, giving a two-dimensional structure parallel to the ab plane. The crystal under investigation was found to be twinned by reticular merohedry with twin fractions of 0.5342 (7:0.4658 (7.

  20. Terminal ileum gangrene secondary to a type IV paraesophageal hernia.

    Hsu, Ching Tsai; Hsiao, Po Jen; Chiu, Chih Chien; Chan, Jenq Shyong; Lin, Yee Fung; Lo, Yuan Hung; Hsiao, Chia Jen

    2016-02-28

    Type IV paraesophageal hernia (PEH) is very rare, and is characterized by the intrathoracic herniation of the abdominal viscera other than the stomach into the chest. We describe a 78-year-old woman who presented at our emergency department because of epigastric pain that she had experienced over the past 24 h. On the day after admission, her pain became severe and was accompanied by right chest pain and dyspnea. Chest radiography revealed an intrathoracic intestinal gas bubble occupying the right lower lung field. Emergency explorative laparotomy identified a type IV PEH with herniation of only the terminal ileum through a hiatal defect into the right thoracic cavity. In this report, we also present a review of similar cases in the literature published between 1980 and 2015 in PubMed. There were four published cases of small bowel herniation into the thoracic cavity during this period. Our patient represents a rare case of an individual diagnosed with type IV PEH with incarceration of only the terminal ileum.

  1. Group IV direct band gap photonics: Methods, Challenges and Opportunities

    Richard eGeiger

    2015-07-01

    Full Text Available The concept of direct band gap group IV materials offers a paradigm change for Si-photonics concerning the monolithic implementation of light emitters: The idea is to integrate fully compatible group IV materials with equally favorable optical properties as the chemically incompatible group III-V-based systems. The concept involves either mechanically applied strain on Ge or alloying of Ge with Sn and permits to drastically improve the insufficient radiative efficiency of Ge. The favorable optical properties result from a modified band structure transformed from an indirect to a direct one. The first demonstration of such a direct band gap laser, accomplished in GeSn, exemplifies the capability of this new concept. These systems may permit a qualitative as well as a quantitative expansion of Si-photonics into traditional but also new areas of applications, provided they can be operated energy efficiently, under ambient conditions and integrated with current Si technologies. This review aims to discuss the challenges along this path in terms of fabrication, characterization and fundamental understanding, and will elaborate on evoking opportunities of this new class of group IV-based laser materials.

  2. Group IV direct band gap photonics: Methods, Challenges and Opportunities

    Geiger, Richard; Zabel, Thomas; Sigg, Hans

    2015-07-01

    The concept of direct band gap group IV materials offers a paradigm change for Si-photonics concerning the monolithic implementation of light emitters: The idea is to integrate fully compatible group IV materials with equally favorable optical properties as the chemically incompatible group III-V-based systems. The concept involves either mechanically applied strain on Ge or alloying of Ge with Sn and permits to drastically improve the insufficient radiative efficiency of Ge. The favorable optical properties result from a modified band structure transformed from an indirect to a direct one. The first demonstration of such a direct band gap laser, accomplished in GeSn, exemplifies the capability of this new concept. These systems may permit a qualitative as well as a quantitative expansion of Si-photonics into traditional but also new areas of applications, provided they can be operated energy efficiently, under ambient conditions and integrated with current Si technologies. This review aims to discuss the challenges along this path in terms of fabrication, characterization and fundamental understanding, and will elaborate on evoking opportunities of this new class of group IV-based laser materials.

  3. The measurement of low IQ with the WAIS-IV: A critical review

    Whitaker, Simon

    2012-01-01

    The WAIS-IV is reviewed for its use in the low IQ range. It has a floor that will elevate low score, does not give accurate percentile ranking and may well systematically measure higher than the WISC-IV.

  4. Towards Revised Step IV MICE Optics in the Absence of M1 SSD

    Bayes, R. [Univ. of Glasgow, Scotland (United Kingdom); Berg, J. S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Blackmore, V. [Imperial College, London (United Kingdom); Hunt, C. [Imperial College, London (United Kingdom); Liu, A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Pasternak, J. [Imperial College, London (United Kingdom); Rogers, C. T. [Science and Technology Facilities Council (STFC), Oxford (United Kingdom). Rutherford Appleton Lab. (RAL)

    2015-10-01

    During magnet commissioning in September 2015, the leads on coil M1 of the downstream spectrometer solenoid failed. The coil will not be operational for MICE Step IV. Revised optics settings for the Step IV data taking are reviewed.

  5. Preparation of UO_2 Fine Particle by Hydrolysis of Uranium(IV) Alkoxide

    Satoh, Isamu; Takahashi, Mitsuyuki; Miura, Shigeyuki

    1997-01-01

    Fine particles of uranium(IV) dioxides were obtained by hydrolysis of uranium(IV) ethoxide which was synthesized by reacting uranium tetrachloride with sodium ethoxide. The monodispersed submicrometer particles were confirmed by SEM observation.

  6. Complex formation reactions of lanthanum(III), cerium(III), thorium(IV), dioxouranyl(IV) complexes with tricine.

    Mohamed, Mahmoud M A

    2007-08-01

    Equilibrium studies for the heavy metal ions La(III), Ce(III), Th(IV) and UO2(IV) (M) complexes of the zwitterionic buffer tricine (L) in aqueous solution are investigated. Stoichiometry and stability constants for the different complexes formed as well as hydrolysis products of the metal cations are determined at 25 degrees C and ionic strength 0.1 M NaNO3. The stability of the formed complexes are discussed in terms of the nature of the heavy metal cation. The solid complexes are synthesized and characterized by means of elemental analysis, FTIR, and TG analysis. The general molecular formulae of the obtained complexes is suggested to be [M(L)2](NO3)n-2(H2O)x, where n = the charge of the metal cation, x = no. of water molecules.

  7. Amine and Titanium (IV Chloride, Boron (III Chloride or Zirconium (IV Chloride-Promoted Baylis-Hillman Reactions

    Shi-Cong Cui

    2001-10-01

    Full Text Available The Baylis-Hillman reactions of various aryl aldehydes with methyl vinyl ketone at temperatures below -20oC using Lewis acids such as titanium (IV chloride, boron (III chloride or zirconium (IV chloride in the presence of a catalytic amount of selected amines used as a Lewis bases afford the chlorinated compounds 1 as the major product in very high yields. Acrylonitrile can also undergo the same reaction to give the corresponding chlorinated product in moderate yield. A plausible reaction mechanism is proposed. However, if the reaction was carried out at room temperature (ca. 20oC, then the Z-configuration of the elimination product 3, derived from 1, was formed as the major product.

  8. Endogeneity in Panel Data Models with Time-Varying and Time-Fixed Regressors: To IV or not IV?

    Mitze, Timo

    We analyse the problem of parameter inconsistency in panel data econometrics due to the correlation of exogenous variables with the error term.A common solution in this setting is to use Instrumental-Variable (IV) estimation in the spirit of Hausman-Taylor (1981). However, some potential...... Carlo simulations, where we explicitly control for the problem of IV selection in the Hausman-Taylor case. The simulation results show that the Hausman- Taylor model with perfect-knowledge about the underlying data structure (instrument orthogonality) has on average the smallest bias. However, compared...... square error (rmse) than both Hausman-Taylor models with perfect and imperfect knowledge about the underlying correlation between r.h.s variables and residual term.This indicates that it is generally more efficient.The results are roughly robust for various combinations in the time and cross...

  9. Advanced clinical interpretation of the WAIS-IV and WMS-IV: prevalence of low scores varies by level of intelligence and years of education.

    Brooks, Brian L; Holdnack, James A; Iverson, Grant L

    2011-06-01

    Clinicians can use the base rates of low scores in healthy people to reduce the likelihood of misdiagnosing cognitive impairment. In the present study, base rates were developed for the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) and Wechsler Memory Scale-Fourth Edition (WMS-IV) using 900 healthy adults and validated on 28 patients with moderate or severe traumatic brain injuries (TBIs). Results indicated that healthy people obtain some low scores on the WAIS-IV/WMS-IV, with prevalence rates increasing with fewer years of education and lower predicted intelligence. When applying the base rates information to the clinical sample, the TBI patients were 13 times more likely to be identified as having a low cognitive profile compared with the controls. Using the base rates information is a psychometrically advanced method for establishing criteria to determine low cognitive abilities on the WAIS-IV/WMS-IV.

  10. Cyclic voltammetry study of Ce(IV/Ce(III redox couple and Ce(IV-F complex in sulfuric acid medium

    J. G. He

    2016-10-01

    Full Text Available In this paper the electrochemical behaviors of Ce(IV/Ce(III redox couple and Ce(IV - F complex in sulfuric acid medium were studied by cyclic voltammetry using a platinum electrode. Both of the Ce(IV/Ce(III couple in Ce(IV solution and Ce(IV - F complex is a quasi-reversible process, and gives a linear correlation between the peak potentials and square root of scan rates, showing that the kinetics of the overall process is diffusion controlled. The complexation of cerium(IV and fluoride is favorable for the oxidation of Ce(III. The kinetic parameters such as diffusion coefficients, anodic transfer coefficients and rate constants were studied.

  11. Distribution of basement membrane type IV collagen alpha chains in ameloblastoma: an immunofluorescence study

    Nakano, K.; Siar, C. H.; Nagai, N.; Naito, I.; Sado, Y.; Nagatsuka, H; Hoh, C; Kurada, K.; Tsujigiwa, H; M. Gunduz

    2002-01-01

    Background: Type IV collagen, a heterotrimeric molecule that exists in six genetically distinct forms, alpha1(IV)-alpha6(IV) is a major structural component of basement membrane (BM) and acts as a scaffold for other BM constituents. Methods: Indirect immunofluorescence using alpha chain-specific monoclonal antibodies was employed to clarify basement membrane (BM) collagen IV distribution in two ameloblastoma, and for comparison, on oral mucosa and tooth germ. Results: Ameloblastoma BM express...

  12. Relationship of local i.v. complications and the method of intermittenti.v. access.

    Hunter, E S; Bell, E; Staub, M A; Coyle, G

    1995-01-01

    Infiltration, infection, phlebitis, and thrombophlebitis are considered the most frequent complications of i.v. therapy. The purpose of our study was to determine if a difference existed in incidence of complications during i.v. infusions depending on whether the i.v. tubing is directly connected to the infusion device or the tubing is connected to the latex port of an i.v. lock using a needle. Background information, mehtod followed, and results obtained in the study are discussed.

  13. No Impact of Body Mass Index on Outcome in Stroke Patients Treated with IV Thrombolysis BMI and IV Thrombolysis Outcome

    Schneider, Juliane; Michel, Patrik; Eskioglou, Elissavet; Kaegi, Georg; Stark, Robert; Fischer, Urs; Jung, Simon; Arnold, Marcel; Wertli, Maria; Held, Ulrike; Wegener, Susanne; Luft, Andreas; Sarikaya, Hakan

    2016-01-01

    Background and Purpose The impact of excess body weight on prognosis after stroke is controversial. Many studies report higher survival rates in obese patients (“obesity paradox”). Recently, obesity has been linked to worse outcomes after intravenous (IV) thrombolysis, but the number and sample size of these studies were small. Here, we aimed to assess the relationship between body weight and stroke outcome after IV thrombolysis in a large cohort study. Methods In a prospective observational multicenter study, we analyzed baseline and outcome data of 896 ischemic stroke patients who underwent IV thrombolysis. Patients were categorized according to body mass index (BMI) as underweight (35 kg/m2). Using uni- and multivariate modeling, we assessed the relationship of BMI with favorable outcome (defined as modified Rankin Scale 0 or 1) and mortality 3 months after stroke as well as the occurrence of symptomatic intracerebral hemorrhages (sICH). We also measured the incidence of patients that had an early neurological improvement of >40% on the National Institutes of Health Stroke Scale (NIHSS) after 24 hours. Results Among 896 patients, 321 were normal weight (35.8%), 22 underweight (2.5%), 378 overweight (42.2%), 123 obese (13.7%) and 52 severely obese (5.8%). Three-month mortality was comparable in obese vs. non-obese patients (8.1% vs. 8.3%) and did not differ significantly among different BMI groups. This was also true for favorable clinical outcome, risk of sICH and early neurological improvement on NIHSS at 24 hours. These results remained unchanged after adjusting for potential confounding factors in the multivariate analyses. Conclusion BMI was not related to clinical outcomes in stroke patients treated with IVT. Our data suggest that the current weight-adapted dosage scheme of IV alteplase is appropriate for different body weight groups, and challenge the existence of the obesity paradox after stroke. PMID:27727305

  14. C-terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin

    Liu, Sicheng; Liu, Xunyue; Kamdar, Radhika Pankaj; Wanotayan, Rujira; Sharma, Mukesh Kumar [Research Laboratory for Nuclear Reactors and Department of Nuclear Engineering, Graduate School of Science and Engineering, Tokyo Institute of Technology, Tokyo 152-8550 (Japan); Adachi, Noritaka [Graduate School of Nanobioscience, Yokohama City University, Yokohama 236-0027 (Japan); Matsumoto, Yoshihisa, E-mail: yoshim@nr.titech.ac.jp [Research Laboratory for Nuclear Reactors and Department of Nuclear Engineering, Graduate School of Science and Engineering, Tokyo Institute of Technology, Tokyo 152-8550 (Japan)

    2013-09-20

    Highlights: •Chromatin binding of XRCC4 is dependent on the presence of DNA ligase IV. •C-terminal region of DNA ligase IV alone can recruit itself and XRCC4 to chromatin. •Two BRCT domains of DNA ligase IV are essential for the chromatin binding of XRCC4. -- Abstract: DNA ligase IV (LIG4) and XRCC4 form a complex to ligate two DNA ends at the final step of DNA double-strand break (DSB) repair through non-homologous end-joining (NHEJ). It is not fully understood how these proteins are recruited to DSBs. We recently demonstrated radiation-induced chromatin binding of XRCC4 by biochemical fractionation using detergent Nonidet P-40. In the present study, we examined the role of LIG4 in the recruitment of XRCC4/LIG4 complex to chromatin. The chromatin binding of XRCC4 was dependent on the presence of LIG4. The mutations in two BRCT domains (W725R and W893R, respectively) of LIG4 reduced the chromatin binding of LIG4 and XRCC4. The C-terminal fragment of LIG4 (LIG4-CT) without N-terminal catalytic domains could bind to chromatin with XRCC4. LIG4-CT with W725R or W893R mutation could bind to chromatin but could not support the chromatin binding of XRCC4. The ability of C-terminal region of LIG4 to interact with chromatin might provide us with an insight into the mechanisms of DSB repair through NHEJ.

  15. Prospective Comparison of Pressor and Airway Responses to IV Esmolol and IV Dexmedetomidine during Emergence from General Anaesthesia and Extubation

    Malvika Prasad Tendulkar

    2017-01-01

    Full Text Available Background: Tracheal extubation causes significant hemodynamic stimulation resulting in transient increase in blood pressure and heart rate. Aim and Objectives: To compare the efficacy of Esmolol and Dexmedetomidine given intravenously to attenuate the pressor and airway response to emergence from general anaesthesia and tracheal extubation. Materials and Methods: After obtaining institutional ethical committee approval and written informed consent, 90 ASA grade I and II patients, in the age group of 20-70 years, of either sex, undergoing elective surgery under general anaesthesia were included. At the end of surgery, patients received IV Esmolol 1.5 mg/kg (Group E two minutes prior to extubation or IV Dexmedetomidine 0.5 mcg/kg (Group D over ten minutes prior to extubation or no drug in the control group (Group C. Hemodynamic parameters were assessed before giving study drugs, before extubation and after extubation upto 15 minutes. Extubation quality was rated using 5 point cough grading. Sedation scoring was done using Modified Ramsay Sedation scale. Results: All hemodynamic parameters showed attenuation upto 15 minutes post extubation, in both Group E and Group D as compared to Group C. However, even though Injection Esmolol successfully controlled the hemodynamic response to extubation, the attenuation was more evident with Injection Dexmedetomidine, as the parameters were below the baseline values at all times after extubation, without excessive bradycardia or hypotension. None of the patients showed incidence of desaturation. The cough grading, and hence the quality of extubation, was better with Group D as compared to Group C and E. Patients in the Dexmedetomidine group, were significantly sedated as compared to Esmolol and Control group, but this aided a smooth extubation without any agitation. Conclusion: We conclude that IV Esmolol 1.5 mg/kg attenuates the pressor response, but IV Dexmedetomidine attenuates both pressor as well as the

  16. Nuclear Data Needs for Generation IV Nuclear Energy Systems

    Rullhusen, Peter

    2006-04-01

    Nuclear data needs for generation IV systems. Future of nuclear energy and the role of nuclear data / P. Finck. Nuclear data needs for generation IV nuclear energy systems-summary of U.S. workshop / T. A. Taiwo, H. S. Khalil. Nuclear data needs for the assessment of gen. IV systems / G. Rimpault. Nuclear data needs for generation IV-lessons from benchmarks / S. C. van der Marck, A. Hogenbirk, M. C. Duijvestijn. Core design issues of the supercritical water fast reactor / M. Mori ... [et al.]. GFR core neutronics studies at CEA / J. C. Bosq ... [et al]. Comparative study on different phonon frequency spectra of graphite in GCR / Young-Sik Cho ... [et al.]. Innovative fuel types for minor actinides transmutation / D. Haas, A. Fernandez, J. Somers. The importance of nuclear data in modeling and designing generation IV fast reactors / K. D. Weaver. The GIF and Mexico-"everything is possible" / C. Arrenondo Sánchez -- Benmarks, sensitivity calculations, uncertainties. Sensitivity of advanced reactor and fuel cycle performance parameters to nuclear data uncertainties / G. Aliberti ... [et al.]. Sensitivity and uncertainty study for thermal molten salt reactors / A. Biduad ... [et al.]. Integral reactor physics benchmarks- The International Criticality Safety Benchmark Evaluation Project (ICSBEP) and the International Reactor Physics Experiment Evaluation Project (IRPHEP) / J. B. Briggs, D. W. Nigg, E. Sartori. Computer model of an error propagation through micro-campaign of fast neutron gas cooled nuclear reactor / E. Ivanov. Combining differential and integral experiments on [symbol] for reducing uncertainties in nuclear data applications / T. Kawano ... [et al.]. Sensitivity of activation cross sections of the Hafnium, Tanatalum and Tungsten stable isotopes to nuclear reaction mechanisms / V. Avrigeanu ... [et al.]. Generating covariance data with nuclear models / A. J. Koning. Sensitivity of Candu-SCWR reactors physics calculations to nuclear data files / K. S

  17. High resolution observations with Artemis-IV and the NRH. I. Type IV associated narrow-band bursts

    Bouratzis, C; Alissandrakis, C E; Preka-Papadema, P; Moussas, X; Caroubalos, C; Tsitsipis, P; Kontogeorgos, A

    2016-01-01

    Narrow band bursts appear on dynamic spectra from microwave to decametric frequencies as fine structures with very small duration and bandwidth. They are thought to mark small scale magnetic reconnection. We analyzed 27 metric type-IV events with narrow band bursts observed by the ARTEMIS-IV radiospectrograph in 30/6/1999-1/8/2010. We examined the morphological characteristics of isolated narrow-band bursts and groups or chains of spikes. The events were recorded with the SAO (10 ms cadence) receiver of ARTEMIS-IV in the 270-450 MHz range. We measured the duration, spectral width, and frequency drift of ~12000 individual narrow-band bursts, groups, and chains. Spike sources were imaged with the NRH for the event of 21 April 2003. The mean duration of individual bursts at fixed frequency was ~100 ms, while the instantaneous relative bandwidth was ~2%. Some bursts had measurable frequency drift, positive or negative. Often spikes appeared in chains, which were closely spaced in time (column chains) or in freque...

  18. A Study on Agreement Rate Between Psychiatric Residents in Diagnosing Axis IV. In DSM-IV Classficatic System

    H. Shahrokhi

    2004-07-01

    Full Text Available Diagnosis of environmental and psychosocial problems in psychiatric patients is essential because of their significant role in causing or exacerbating psychiatric disorders. This study was carried out to assess the consensus rate in diagnosing axis IV (environmental and psychosocial problems in DSM-IV system of classification among psychiatric residents.In this study one hundred and seventeen psychiatric patients were examined in daily morning in Razi Mental Hospital in Tabriz. The patients were evaluated individually by residents in regard to mental status and axis IV problems. The obtained datas were analysed by descriptive and inferential statistical methods.Results of the study revealed that consensus rate among residents in assessment of environmental and psychosocial problem(s was low (ICC : 0.22. Demographic characteristics of the patients did not explain difference between residents. Sex and familiarity of residents with Azari Language were significantly important regarding diagnostic difference, so that consensus rate in female residents was more than male ones and in Azari speaking residents was more than non-Azari speaking ones. No part of mental status examination was remarkable in explaining diagnostic differences. Diagnoses in axis I and III were recognized as important elements in explaining the differences.Based on result of this study diagnosis of environmental and psychosocial problems in psychiatric patients by residents generally is not reliable and the issue warrant further attention.

  19. The Effectiveness of Dibutyltin (IV and Di-tert-butyltin (IV Alkyl-phenyl Dithiocarbamate Compounds as Larvicide against Aedes aegypti Linn. (Diptera: Culicidae in Laboratory

    Normah Awang

    2014-10-01

    Full Text Available Extensive use of insecticides to control dengue vectors has led to the development of mosquito resistance, environmental pollution and undesirable effects on non target organisms. Thus, the potential of organotin (IV compounds has been explored to be developed as insecticides to obviate the existing problems. The aim of this study was to examine the larvicidal effect of dibutylt in (IV and di-tert-butyltin (IV alkyl-phenyl dithiocarbamate compounds against Aedes aegypti Linn. in laboratory. Larvicidal bioassay test of four compounds dibutyltin (IV ethyl phenyl dithiocarbamate, di-tert-butyltin (IV ethyl phenyl dithiocarbamate, dibutyltin (IV butyl phenyl dithiocarbamate and di-tert-butyltin (IV butyl phenyl dithiocarbamate against third instar larvae of A. aegypti was carried out. The study indicated that dibutyltin (IV butyl phenyl dithiocarbamate showed the highest larvicidal effect with LC50 and LC90 values of 0.59 and 3.91 ppm, respectively. However, the other three compounds showed lower larvicidal effects. Dibutyltin (IV ethyl phenyl dithiocarbamate showed moderate larvicidal effect with LC50 and LC90 values of 4.45 and 11.08 ppm, respectively, followed by di-tert-butyltin (IV butyl phenyl dithiocarbamate compound with LC50 and LC90 values of 5.08 and 11.50 ppm, respectively. Di-tert-butyltin (IV ethyl phenyl dithiocarbamate compound showed the least larvicidal effect with LC50 and LC90 values of 8.59 and 36.74 ppm, respectively. Morphological anomalies such as elongated neck region, shortened length and destructed digestive tract in the larvae were observed and recorded during the larvicidal bioassay testing. As a conclusion, dibutyltin (IV butyl phenyl dithiocarbamate compound is the most effective compound against the dengue vector, A. aegypti and has the potential to be explored as a larvicide. Further study is needed to ensure that this compound can be used safely as a larvicide.

  20. Possible association of elevated serum collagen type IV level with skin sclerosis in systemic sclerosis.

    Motegi, Sei-Ichiro; Sekiguchi, Akiko; Fujiwara, Chisako; Toki, Sayaka; Ishikawa, Osamu

    2016-08-29

    Collagen type IV is the primary collagen in the basement membranes around blood vessels and in the dermoepidermal junction in the skin. Perivascular collagen type IV is synthesized by endothelial cells and pericytes, and contributes to the homeostasis and remodeling of blood vessels. It has been well recognized that elevated serum collagen type IV levels are associated with the liver fibrosis. The objective was to examine serum collagen type IV levels and their clinical associations in patients with systemic sclerosis (SSc), and to examine the expression of collagen type IV in the fibrotic skin in SSc. Serum collagen type IV levels in SSc patients and diffuse cutaneous type SSc patients were significantly higher than those in healthy individuals. Serum collagen type IV levels were positively correlated with modified Rodnan total skin score. Serum collagen type IV levels in early stage (disease duration ≤3 years) diffuse cutaneous SSc patients were significantly elevated. Serum collagen type IV levels in SSc patients with digital ulcers (DU) were significantly elevated. In immunohistochemical staining, the expression of collagen type IV around dermal small vessels in the affected skin was reduced compared with those of normal individuals. These results suggest that elevated serum collagen type IV levels may be associated with the skin sclerosis in the early stage of SSc. The measurement of serum collagen type IV levels in SSc patients may be useful as a disease activity marker in skin sclerosis and DU.

  1. 21 CFR 866.5360 - Cohn fraction IV immuno-logical test system.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cohn fraction IV immuno-logical test system. 866.5360 Section 866.5360 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....5360 Cohn fraction IV immuno-logical test system. (a) Identification. A Cohn fraction IV...

  2. Orthogonal Higher Order Structure of the WISC-IV Spanish Using Hierarchical Exploratory Factor Analytic Procedures

    McGill, Ryan J.; Canivez, Gary L.

    2016-01-01

    As recommended by Carroll, the present study examined the factor structure of the Wechsler Intelligence Scale for Children-Fourth Edition Spanish (WISC-IV Spanish) normative sample using higher order exploratory factor analytic techniques not included in the WISC-IV Spanish Technical Manual. Results indicated that the WISC-IV Spanish subtests were…

  3. Assessing Intellectual Functioning in Young Adolescents: How Do the WISC-IV and SB5 Compare?

    Wilson, Kimberley; Gilmore, Linda

    2012-01-01

    The Wechsler Intelligence Scale for Children--Fourth Edition (WISC-IV) and the Stanford-Binet--Fifth Edition (SB5) are two of the most commonly used intelligence tests for children and adolescents. No comparative studies of the WISC-IV and SB5 have yet been published. In the current study the WISC-IV and SB5 were administered in counterbalanced…

  4. Reliability of DSM-IV Symptom Ratings of ADHD: Implications for DSM-V

    Solanto, Mary V.; Alvir, Jose

    2009-01-01

    Objective: The objective of this study was to examine the intrarater reliability of "DSM-IV" ADHD symptoms. Method: Two-hundred-two children referred for attention problems and 49 comparison children (all 7-12 years) were rated by parents and teachers on the identical "DSM-IV" items presented in two different formats, the SNAP-IV and Conners'…

  5. Indicators of suboptimal performance embedded in the Wechsler Memory Scale-Fourth Edition (WMS-IV)

    Bouman, Z.; Hendriks, M.P.H.; Schmand, B.A.; Kessels, R.P.C.; Aldenkamp, A.P.

    2016-01-01

    Introduction. Recognition and visual working memory tasks from the Wechsler Memory Scale-Fourth Edition (WMS-IV) have previously been documented as useful indicators for suboptimal performance. The present study examined the clinical utility of the Dutch version of the WMS-IV (WMS-IV-NL) for the ide

  6. 75 FR 33421 - Supplemental Nutrition Assistance Program: Quality Control Provisions of Title IV of Public Law...

    2010-06-11

    ... Program: Quality Control Provisions of Title IV of Public Law 107-171; Final Rule #0;#0;Federal Register... Assistance Program: Quality Control Provisions of Title IV of Public Law 107-171 AGENCY: Food and Nutrition... ``Food Stamp Program: Non-Discretionary Quality Control Provisions of Title IV of Public Law...

  7. IV Iron: To Give or to Hold in the Presence of Infection in Adults Undergoing Hemodialysis.

    Hain, Debra; Braun, Mauro

    2015-01-01

    Intravenous (IV) iron is often given to treat iron deficiency anemia in adults undergoing hemodialysis. Evidence supports an association between IV iron and infection exits, which often create a clinical dilemma: whether to give or to hold in the presence of infection. This article presents the best available evidence regarding the risk of IV iron and infection along with nephrology nursing practice implications.

  8. Solar Transition-Region Lines Observed by the Interface Region Imaging Spectrograph: Diagnostics for the O IV and Si IV Lines

    Dudík, Jaroslav; Dzifčáková, Elena; Mason, Helen E; Golub, Leon

    2013-01-01

    The formation of the transition-region O IV and Si IV lines observable by the Interface Region Imaging Spectrograph (IRIS) is investigated for both Maxwellian and non-Maxellian conditions characterized by a kappa-distribution exhibiting a high-energy tail. The \\ion{Si}{4} lines are formed at lower temperatures than the O IV lines for all kappa. In non-Maxwellian situations with lower kappa, the contribution functions are shifted to lower temperatures. Combined with the slope of the differential emission measure, it is possible for the Si IV lines to be formed at very different regions of solar transition region than the O IV lines; possibly close to solar chromosphere. Such situations might be discernible by IRIS. It is found that photoexcitation can be important for the Si IV lines, but is negligible for the O IV lines. The usefulness of the O IV ratios for density diagnostics independently of kappa is investigated and it is found that the O IV 1404.78A /1399.77A ratio provides a good density diagnostics exc...

  9. X-Band Electron Paramagnetic Resonance Comparison of Mononuclear Mn(IV)-oxo and Mn(IV)-hydroxo Complexes and Quantum Chemical Investigation of Mn(IV) Zero-Field Splitting.

    Leto, Domenick F; Massie, Allyssa A; Colmer, Hannah E; Jackson, Timothy A

    2016-04-04

    X-band electron paramagnetic resonance (EPR) spectroscopy was used to probe the ground-state electronic structures of mononuclear Mn(IV) complexes [Mn(IV)(OH)2(Me2EBC)](2+) and [Mn(IV)(O)(OH)(Me2EBC)](+). These compounds are known to effect C-H bond oxidation reactions by a hydrogen-atom transfer mechanism. They provide an ideal system for comparing Mn(IV)-hydroxo versus Mn(IV)-oxo motifs, as they differ by only a proton. Simulations of 5 K EPR data, along with analysis of variable-temperature EPR signal intensities, allowed for the estimation of ground-state zero-field splitting (ZFS) and (55)Mn hyperfine parameters for both complexes. From this analysis, it was concluded that the Mn(IV)-oxo complex [Mn(IV)(O)(OH)(Me2EBC)](+) has an axial ZFS parameter D (D = +1.2(0.4) cm(-1)) and rhombicity (E/D = 0.22(1)) perturbed relative to the Mn(IV)-hydroxo analogue [Mn(IV)(OH)2(Me2EBC)](2+) (|D| = 0.75(0.25) cm(-1); E/D = 0.15(2)), although the complexes have similar (55)Mn values (a = 7.7 and 7.5 mT, respectively). The ZFS parameters for [Mn(IV)(OH)2(Me2EBC)](2+) were compared with values obtained previously through variable-temperature, variable-field magnetic circular dichroism (VTVH MCD) experiments. While the VTVH MCD analysis can provide a reasonable estimate of the magnitude of D, the E/D values were poorly defined. Using the ZFS parameters reported for these complexes and five other mononuclear Mn(IV) complexes, we employed coupled-perturbed density functional theory (CP-DFT) and complete active space self-consistent field (CASSCF) calculations with second-order n-electron valence-state perturbation theory (NEVPT2) correction, to compare the ability of these two quantum chemical methods for reproducing experimental ZFS parameters for Mn(IV) centers. The CP-DFT approach was found to provide reasonably acceptable values for D, whereas the CASSCF/NEVPT2 method fared worse, considerably overestimating the magnitude of D in several cases. Both methods were poor in

  10. Pt(IV) complexes as prodrugs for cisplatin.

    Shi, Yi; Liu, Shu-An; Kerwood, Deborah J; Goodisman, Jerry; Dabrowiak, James C

    2012-02-01

    The antitumor effects of platinum(IV) complexes, considered prodrugs for cisplatin, are believed to be due to biological reduction of Pt(IV) to Pt(II), with the reduction products binding to DNA and other cellular targets. In this work we used pBR322 DNA to capture the products of reduction of oxoplatin, c,t,c-[PtCl(2)(OH)(2)(NH(3))(2)], 3, and a carboxylate-modified analog, c,t,c-[PtCl(2)(OH)(O(2)CCH(2)CH(2)CO(2)H)(NH(3))(2)], 4, by ascorbic acid (AsA) or glutathione (GSH). Since carbonate plays a significant role in the speciation of platinum complexes in solution, we also investigated the effects of carbonate on the reduction/DNA-binding process. In pH 7.4 buffer in the absence of carbonate, both 3 and 4 are reduced by AsA to cisplatin (confirmed using ((195))Pt NMR), which binds to and unwinds closed circular DNA in a manner consistent with the formation of the well-known 1, 2 intrastrand DNA crosslink. However, when GSH is used as the reducing agent for 3 and 4, ((195))Pt NMR shows that cisplatin is not produced in the reaction medium. Although the Pt(II) products bind to closed circular DNA, their effect on the mobility of Form I DNA is different from that produced by cisplatin. When physiological carbonate is present in the reduction medium, ((13))C NMR shows that Pt(II) carbonato complexes form which block or impede platinum binding to DNA. The results of the study vis-à-vis the ability of the Pt(IV) complexes to act as prodrugs for cisplatin are discussed.

  11. Adsorption and colloidal behaviour of traces of tellurium(IV) and aqueous solutions

    Maruyama, Y.; Yamaashi, Y.

    1985-08-01

    Various NaCl solutions containing traces of tellurium(IV) were prepared. The effects of tellurium(IV) concentration and pH on the adsorption of tellurium(IV) on filter paper were studied by filtration method. The effects of NaCl concentration, tellurium(IV) concentration and pH on the formation of a colloid were also studied by ultracentrifugation and ultrafiltration methods. It was found that tellurium(IV) at concentrations below about 10sup(-10)M in neutral NaCl solutions is adsorbed on filter paper and shows colloidal behaviour. (author). 4 refs.; 7 figs.

  12. Dipeptidyl peptidase IV is sorted to the secretory granules in pancreatic islet A-cells

    Poulsen, Mona Dam; Hansen, Gert Helge; Dabelsteen, Erik

    1993-01-01

    Dipeptidyl peptidase IV (DP IV:EC 3.4.14.5) was localized in endocrine cells of pig pancreas by immunohistochemical and enzyme histochemical methods. Immunolight microscopy with both monoclonal and polyclonal antibodies demonstrated DP IV immunoreactivity in cells located in the peripheral part...... labeling using a monoclonal glucagon antibody as the second primary antibody. These results show that DP IV is sorted to secretory granules in the pig pancreatic islet A-cells. Furthermore, this secretory granule enzyme, as opposed to intestinal brush border DP IV, is suggested to be a soluble protein...

  13. IV Congreso Nacional de Investigaciones en Antropología

    2014-01-01

    El IV congreso nacional de investigaciones en antropología se desarrolló de acuerdo a lo previsto, entre el 1º y el 6 de agosto de 2005. La organización estuvo a cargo de un comité compuesto por tres profesores de la Universidad Nacional Mayor de San Marcos (Román Robles, Mercedes Giesecke y Rommel Plascencia) y tres de la Pontificia Universidad Católica del Perú (Gisela Cánepa, Cecilia Rivera y Alejandro Diez); a ellos se les sumaron Humberto Rodríguez del CONCYTEC y Juan José García del INC...

  14. El soterrado cristianismo de Iván Illich

    Santos Gómez, Marcos

    2016-01-01

    Mostramos una clave cristiana subyacente en el pensamiento de Iván Illich. A partir del planteamiento del último Foucault de los cursos en el Collège de France, hemos entendido algunos elementos del primitivo cristianismo como artífices y educadores de la subjetividad. Desde esta perspectiva de un cristianismo como base que mueve a la configuración de sujeto y de las relaciones intersubjetivas, entendemos la “pedagogía” de Illich We show an underlying Christian key in thinki...

  15. Calysolins I-IV, resin glycosides from Calystegia soldanella.

    Takigawa, Ayako; Muto, Haruka; Kabata, Kiyotaka; Okawa, Masafumi; Kinjo, Junei; Yoshimitsu, Hitoshi; Nohara, Toshihiro; Ono, Masateru

    2011-11-28

    Four new resin glycosides having intramolecular cyclic ester structures (jalapins), named calysolins I-IV (1-4), were isolated from the methanol extract of leaves, stems, and roots of Calystegia soldanella , along with one known jalapin (5) derivative. The structures of 1-4 were determined on the basis of spectroscopic data and chemical evidence. They fall into two types, one having a 22-membered ring (1 and 4) and the other with a 27-membered ring (2 and 3). The sugar moieties of 1-4 were partially acylated by some organic acids. Compound 4 is the first example of a hexaglycoside of jalapin.

  16. Apollonius de Perges, Coniques tome 2.2, livre IV

    Rashed, Roshdi

    2009-01-01

    Book IV of the Konika consists of two parts; the first presents a theory of poles and polars, the second deals with the number of intersections and points of contact in a conic section. Previously the book was only extant as the very unreliable text of a Greek commentary by Eutocius. Roshdi Rashed here presents for the first time an edition of an Arabic translation based on a text independent of this Greek version. This is a valuable re-discovery, for which reason it is published here as a separate volume. It contains an edition princeps of the Arabic text, together with a faithful translation

  17. Neurogenic pulmonary edema: successful treatment with IV phentolamine.

    Davison, Danielle L; Chawla, Lakhmir S; Selassie, Leelie; Tevar, Rahul; Junker, Christopher; Seneff, Michael G

    2012-03-01

    Neurogenic pulmonary edema (NPE) is a clinical syndrome characterized by the acute onset of pulmonary edema following a significant CNS insult. The cause is believed to be a surge of catecholamines that results in cardiopulmonary dysfunction. Although there are myriad case reports describing CNS events that are associated with this syndrome, few studies have identified specific treatment modalities. We present a case of NPE caused by an intracranial hemorrhage from a ruptured arteriovenous malformation. We uniquely document a rise and fall of serum catecholamine levels correlating with disease activity and a dramatic clinical response to IV phentolamine.

  18. Partial Return Yoke for MICE Step IV and Final Step

    Witte, Holger [Brookhaven; Plate, Stephen [Brookhaven; Berg, J.Scott [Brookhaven; Tarrant, Jason [Rutherford; Bross, Alan [Fermilab

    2015-06-01

    This paper reports on the progress of the design and construction of a retro-fitted return yoke for the international Muon Ionization Cooling Experiment (MICE). MICE is a proof-of-principle experiment aiming to demonstrate ionization cooling experimentally. In earlier studies we outlined how a partial return yoke can be used to mitigate stray magnetic field in the experimental hall; we report on the progress of the construction of the partial return yoke for MICE Step IV. We also discuss an extension of the Partial Return Yoke for the final step of MICE; we show simulation results of the expected performance.

  19. Partial return yoke for MICE step IV and final step

    Witte, H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Plate, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Berg, J. S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Tarrant, J. [Science and Technology Facilities Council (STFC), Oxford (United Kingdom). Rutherford Appleton Lab. (RAL); Bross, A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2015-05-03

    This paper reports on the progress of the design and construction of a retro-fitted return yoke for the international Muon Ionization Cooling Experiment (MICE). MICE is a proof-of-principle experiment aiming to demonstrate ionization cooling experimentally. In earlier studies we outlined how a partial return yoke can be used to mitigate stray magnetic field in the experimental hall; we report on the progress of the construction of the partial return yoke for MICE Step IV. We also discuss an extension of the Partial Return Yoke for the final step of MICE; we show simulation results of the expected performance.

  20. Le Tumulus - Cromlech de Millagate IV. Etude des Restes Humains.

    Henry Duday

    1988-01-01

    Full Text Available El túmulo - cromlech de Millagate IV ha ofrecido restos incinerados de un solo individuo adulto, probablemente masculino. El esqueleto del tronco se encuentra poco representado respecto a la cabeza y miembros. Esto puede deberse a un proceso de destrucción diferencial por el fuego. Metodológicamente, en lo que concierne a la cuantificación relativa de las diferentes partes del cuerpo, el peso parece un mejor parámetro que el número de fragmentos.

  1. Mexico; Staff Report for the 2013 Article IV Consultation

    International Monetary Fund.

    2013-01-01

    This 2013 Article IV Consultation highlights that over the past year, Mexico has maintained macroeconomic policy continuity, while pursuing an ambitious agenda of growth-enhancing reforms. Reforms have already been approved to upgrade education, make labor markets more flexible, and foster competition in telecommunications. In 2013, the economy has begun to operate well below capacity, with real GDP growth expected to slow to 1.2 percent (down from 3.6 percent in 2012). The banking system—w...

  2. The use of IV lipid emulsion for lipophilic drug toxicities.

    Kaplan, Amy; Whelan, Megan

    2012-01-01

    IV lipid emulsion (ILE) therapy is emerging as a potential antidote for lipophilic drug toxicities in both human and veterinary medicine. ILE has already gained acceptance in human medicine as a treatment of local anesthetic systemic toxicity, but its mechanism of action, safety margins, and standardized dosing information remains undetermined at this time. Experimental and anecdotal use of ILE in the human and veterinary literature, theorized mechanisms of action, current dosing recommendations, potential adverse effects, and indications for use in human and veterinary emergency medicine are reviewed herein.

  3. La sucesión de Enrique IV

    María Isabel del Val Valdivieso

    1991-01-01

    Full Text Available Quizá resulte superfluo señalar que el problema que se plantea a lo largo del reinado de Enrique IV, en torno a su sucesión, no es sino uno de los episodios más espectaculares de la lucha por el poder que tiene lugar en la Castilla de ese momento. No obstante se hace necesario partir de esa observación a la hora de explicar las causas y el desarrollo de esa lucha, así como el por qué de la aparición del problema sucesorio.

  4. Phase Transitions in Layered Diguanidinium Hexachlorostannate(IV)

    Szafranski, Marek; Ståhl, Kenny

    2016-01-01

    Five crystalline phases of diguanidinium hexachlorostannate(IV), [C(NH2)(3)](2)SnCl6, have been identified and characterized by calorimetric and dielectric measurements, single crystal X-ray diffraction at atmospheric and high pressure, and synchrotron X-ray powder diffraction. The crystal...... structures of all phases are built of similar layers in which the tin hexachloride anions are connected to the guanidinium cations by N-H center dot center dot center dot Cl hydrogen bonds, forming a interact primarily by Coulombic forces between the ions from ap. double H-bonded sheets. The layers, neutral...

  5. Benzylchloridobis(quinolin-8-olato)tin(IV)

    Qibao Wang

    2009-01-01

    In the title compound, [Sn(C7H7)(C9H6NO)2Cl], the SnIV ion is in a distorted octahedral coordination environment formed by the O and N atoms of two bis-chelating quinolin-8-olate ligands, a Cl atom and a C atom from a benzyl ligand. The axial sites are occupied by an N atom of a quinolinate ligand and the C atom of the benzyl ligand. The axial Sn—N bond is slightly shorter than the equatorial Sn—N bond.

  6. Benzyl-chloridobis(quinolin-8-olato)tin(IV).

    Wang, Qibao

    2009-07-11

    In the title compound, [Sn(C(7)H(7))(C(9)H(6)NO)(2)Cl], the Sn(IV) ion is in a distorted octa-hedral coordination environment formed by the O and N atoms of two bis-chelating quinolin-8-olate ligands, a Cl atom and a C atom from a benzyl ligand. The axial sites are occupied by an N atom of a quinolinate ligand and the C atom of the benzyl ligand. The axial Sn-N bond is slightly shorter than the equatorial Sn-N bond.

  7. Benzyl­chloridobis(quinolin-8-olato)tin(IV)

    Wang, Qibao

    2009-01-01

    In the title compound, [Sn(C7H7)(C9H6NO)2Cl], the SnIV ion is in a distorted octa­hedral coordination environment formed by the O and N atoms of two bis-chelating quinolin-8-olate ligands, a Cl atom and a C atom from a benzyl ligand. The axial sites are occupied by an N atom of a quinolinate ligand and the C atom of the benzyl ligand. The axial Sn—N bond is slightly shorter than the equatorial Sn—N bond.

  8. Comparison between different reactions of group IV hydride with H

    ZHANG; Shaolong; ZHANG; Xuqiang; ZHANG; Qinggang; ZHANG; Yici

    2006-01-01

    The four-dimensional time-dependent quantum dynamics calculations for reactions of group IV hydride with H are carried out by employing the semirigid vibrating rotor target model and the time-dependent wave packet method. The reaction possibility, cross section and rate constants for reactions (H+SiH4 and H+GeH4) in different initial vibrational and rotational states are obtained. The common feature for such kind of reaction process is summarized. The theoretical result is consistent with available measurement, which indicates the credibility of this theory and the potential energy surface.

  9. Sulfur(IV)-mediated carbon-carbon bond formation

    Dean, William Michael

    2016-01-01

    This thesis details the development of methods for and application of the synthesis of carbon carbon bonds using organic sulfur(IV) chemistry. More specifically, the formation of C(sp2) C(sp3) and C(sp3) C(sp3) bonds is explored in detail. The necessity for this research stems from a correlation between a high proportion of sp3 centres in drug candidates, and their success in clinical trials. By facilitating the synthesis of drug candidates with higher fractions of sp3 hybridised carbon atoms...

  10. Tribenzylchlorido(triphenylphosphine oxide-κOtin(IV

    Kong Mun Lo

    2011-06-01

    Full Text Available In the title tribenzylchloridotin–triphenylphosphine adduct, [Sn(C7H73Cl(C18H15OP], the SnIV atom is in a trans-C3SnClO trigonal–bipyramidal geometry and is displaced out of the C3Sn girdle in the direction of the axial Cl atom by 0.112 (1 in one independent molecule and by 0.167 (1 Å in the other. The phenyl ring of one of the six benzyl units was refined as equally disordered over two sets of sites.

  11. Tolman IV solution in the Randall-Sundrum braneworld

    Ovalle, J.; Linares, F.

    2013-11-01

    In the context of the Randall-Sundrum braneworld, the minimal geometric deformation approach is used to generate an analytic interior solution to four-dimensional effective Einstein field equations for a spherically symmetric compact distribution. This solution represents the braneworld version of the well-known Tolman IV solution in general relativity. By using this analytic solution, an exhaustive analysis of the braneworld effects on realistic stellar interiors is developed, finding strong evidence in favor of the hypothesis that compactness is reduced due to bulk effects on stellar configurations.

  12. Tolman IV solution in the Randall-Sundrum Braneworld

    Ovalle, J

    2013-01-01

    In the context of the Randall-Sundrum braneworld, the minimal geometric deformation approach (MGD) is used to generate an exact analytic interior solution to four-dimensional effective Einstein's field equations for a spherically symmetric compact distribution. This solution represents the braneworld version of the well known Tolman IV solution in General Relativity. By using this analytic solution, an exhaustive analysis of the braneworld effects on realistic stellar interiors is developed, finding strong evidences in favor of the hypothesis that compactness is reduced due to bulk effects on stellar configurations.

  13. Terra e terror em Phase IV, de Saul Bass

    2016-01-01

    Os anos 1970 foram palco de uma onda de filmes do gênero eco-horror, dos quais se destaca Phase IV (1974), único longa-metragem dirigido por Saul Bass. O filme é tomado no artigo como um experimento diante da interpelação de povos não-humanos, no caso, as formigas, à humanidade, representada pelo discurso científico. Tendo em vista a atual catástrofe ambiental, propõe-se que o cinema seja um lugar privilegiado para o desenvolvimento de um aparato mítico-real capaz de lidar com o fim do mundo ...

  14. Terra e terror em Phase IV, de Saul Bass

    Juliana Fausto

    2016-07-01

    Full Text Available Os anos 1970 foram palco de uma onda de filmes do gênero eco-horror, dos quais se destaca Phase IV (1974, único longa-metragem dirigido por Saul Bass. O filme é tomado no artigo como um experimento diante da interpelação de povos não-humanos, no caso, as formigas, à humanidade, representada pelo discurso científico. Tendo em vista a atual catástrofe ambiental, propõe-se que o cinema seja um lugar privilegiado para o desenvolvimento de um aparato mítico-real capaz de lidar com o fim do mundo humano.

  15. Symptomatic Type IV Dual Left Anterior Descending Coronary Artery

    Kyriacos Papadopoulos MD

    2016-12-01

    Full Text Available Dual left anterior descending coronary artery is a rare congenital anomaly with 4 subtypes. Double left anterior descending coronary artery originating from the left main stem and the right coronary artery (type IV dual left anterior descending artery has been reported to occur in 0.01% to 0.7% of patients undergoing cardiac catheterization. We report a case of a 49-year-old woman who was found to have this anomaly during coronary angiography. The patient had been complaining of chest pain that mimics angina pectoris and exercise tolerance test was positive for myocardial ischemia.

  16. Structure of ice IV, a metastable high-pressure phase

    Engelhardt, Hermann; Kamb, Barclay

    1981-12-01

    Ice IV, made metastably at pressures of about 4 to 5.5 kb, has a structure based on a rhombohedral unit cell of dimensions aR = 760±1 pm, α = 70.1±0.2°, space group R3¯c, as observed by x-ray diffraction at 1 atm, 110 K. The cell contains 12 water molecules of type 1, in general position, plus 4 of type 2, with O(2) in a special position on the threefold axis. The calculated density at 1 atm, 110 K is 1.272±0.005 g cm-3. Every molecule is linked by asymmetric H bonds to four others, the bonds forming a new type of tetrahedrally-connected network. Molecules of type 1 are linked by O(1)ṡṡṡO(1') bonds into puckered six-rings of 3¯ symmetry, through the center of each of which passes an O(2)ṡṡṡO(2') bond between a pair of type-2 molecules, along the threefold axis. The six-rings are linked laterally by type-2 molecules to form puckered sheets that are topologically similar to such sheets in ice I, but are connected to one another in a very different and novel way. One quarter of the intersheet bonds connect not directly between adjacent sheets but remotely, from one sheet to the second nearest sheet, through holes in the intervening sheet. These remote connections are the O(2)ṡṡṡO(2') bonds, passing through the O(1)-type six-rings. The sheets are stacked in a sequence based on ice Ic, modified by reversal of the puckering to form the remote connections and by internal distortion of the sheets to complete the remaining intersheet bonds. Of the four nonequivalent H bonded OṡṡṡO distance in the structure, two (279 and 281±1pm) are only moderately lengthened relative to the bonds in ice I (275 pm), whereas the O(1)ṡṡṡO(1') bond (288±1pm) and O(2)ṡṡṡO(2') bond (292±1pm) are lengthened extraordinarily. This is caused by repulsion between O(1) and O(2) at nonbonded distances of 314 and 329 pm in the molecular cluster consisting of the O(1)-type six-ring threaded by the O(2)ṡṡṡO(2') bond. The mean OṡṡṡO bond distance of

  17. Czech Republic; Staff Report for the 2004 Article IV Consultation

    2004-01-01

    This 2004 Article IV Consultation highlights that the Czech Republic’s GDP expanded by 3.1 percent in 2003 and the first quarter of 2004, mainly supported by household consumption. Investment was also strong in 2003—driven by spending on public infrastructure—and swelled in early 2004 owing to one-off influences associated with European Union accession. The fiscal deficit continued to drift upward in 2003. The general government deficit widened relative to GDP by about 1 percentage poin...

  18. Effect of Supercoiling on the Mechanical and Permeability Properties of Model Collagen IV Networks.

    Gyoneva, Lazarina; Segal, Yoav; Dorfman, Kevin D; Barocas, Victor H

    2015-07-01

    Collagen IV networks in the glomerular basement membrane (GBM) are essential for the maintenance and regulation of blood filtration in the kidneys. The GBM contains two different types of collagen IV networks: [α1(IV)]2α2(IV) and α3(IV)α4(IV)α5(IV), the latter of which has a higher number of supercoils (two or more collagens coiling around each other). To investigate the effects of supercoiling on the mechanical and permeability properties of collagen IV networks, we generated model collagen IV networks in the GBM and reconnected them to create different levels of supercoiling. We found that supercoiling greatly increases the stiffness of collagen IV networks but only minimally decreases the permeability. Also, doubling the amount of supercoils in a network had a bigger effect than doubling the stiffness of the supercoils. Our results suggest that the formation of supercoils is a specialized mechanism by the GBM that provides with a network stiff and strong enough to withstand the high hydrostatic pressures of filtration, yet porous enough that filtration is not hindered. Clinically, understanding the effects of supercoiling gives us insight into the mechanisms of GBM failure in some disease states where the normal collagen IV structure is disrupted.

  19. Identification and characterization of a dipeptidyl peptidase IV inhibitor from aronia juice

    Kozuka, Miyuki [Department of Health and Nutrition, Faculty of Human Science, Hokkaido Bunkyo University, Eniwa 061-1449 (Japan); Yamane, Takuya, E-mail: t-yamane@pharm.hokudai.ac.jp [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812 (Japan); Nakano, Yoshihisa [Center for Research and Development Bioresources, Research Organization for University-Community Collaborations, Osaka Prefecture University, Sakai, Osaka 599-8570 (Japan); Nakagaki, Takenori [Institute of Food Sciences, Nakagaki Consulting Engineer Co., Ltd, Nishi-ku, Sakai 593-8328 (Japan); Ohkubo, Iwao [Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Higashi-ku, Sapporo 065-0013 (Japan); Ariga, Hiroyoshi [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812 (Japan)

    2015-09-25

    Aronia berries have many potential effects on health, including an antioxidant effect, effect for antimutagenesis, hepatoprotection and cardioprotection, an antidiabetic effect and inhibition of cancer cell proliferation. Previous human studies have shown that aronia juice may be useful for treatment of obesity disorders. In this study, we found that aronia juice has an inhibitory effect against dipeptidyl peptidase IV (DPP IV) (EC 3.4.14.5). DPP IV is a peptidase that cleaves the N-terminal region of incretins such as glucagon-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Inactivation of incretins by DPP IV induces reduction of insulin secretion. Furthermore, we identified that cyanidin 3, 5-diglucoside as the DPP IV inhibitor in aronia juice. DPP IV was inhibited more strongly by cyanidin 3, 5-diglucoside than by cyanidin and cyanidin 3-glucoside. The results suggest that DPP IV is inhibited by cyanidin 3, 5-diglucoside present in aronia juice. The antidiabetic effect of aronia juice may be mediated through DPP IV inhibition by cyanidin 3, 5-diglucoside. - Highlights: • DPP IV activity is inhibited by aronia juice. • DPP IV inhibitor is cyanidin 3, 5-diglucoside in aronia juice. • DPP IV is inhibited by cyanidin 3, 5-diglucoside more than cyanidin and cyanidin 3-glucoside.

  20. Collagen alpha5 and alpha2(IV) chain coexpression: analysis of skin biopsies of Alport patients.

    Patey-Mariaud de Serre, N; Garfa, M; Bessiéres, B; Noël, L H; Knebelmann, B

    2007-08-01

    Alport syndrome is a collagen type IV disease caused by mutations in the COL4A5 gene with the X-linked form being most prevalent. The resultant alpha5(IV) collagen chain is a component of the glomerular and skin basement membranes (SBMs). Immunofluorescent determination of the alpha5(IV) chain in skin biopsies is the procedure of choice to identify patients. In 30% of patients, however, the mutant protein is still found in the SBM resulting in a normal staining pattern. In order to minimize or eliminate false results, we compared the distribution of the alpha2(IV) chain (another SBM component) and the alpha5(IV) chain by standard double label immunofluorescence (IF) and by confocal laser scanning microscopy. The study was performed on 55 skin biopsies of patients suspected of Alports and five normal control specimens. In normal skin, IF showed the classical linear pattern for both collagens along the basement membrane. Additionally, decreased alpha5(IV) was found in the bottom of the dermal papillary basement membrane. Confocal analysis confirmed the results and show alpha5(IV) focal interruptions. In suspected patients, both techniques showed the same rate of abnormal alpha5(IV) expression: segmental in women and absent in men. Our results show a physiological variation of alpha5(IV) location with focal interruptions and decreased expression in the bottom of the dermal basement membrane. Comparison of alpha5(IV) with alpha2(IV) expression is simple and eliminates technical artifacts.

  1. Investigation on Concentrated V(IV)/V(V) Redox Reaction by Rotating Disc Voltammetry

    WEN Yue-Hua; ZHANG Hua-Min; QIAN Peng; MA Hai-Peng; YI Bao-Lian; YANG Yu-Sheng

    2007-01-01

    The kinetic characteristics of the concentrated V(IV)/V(V) couple have been studied at a glassy carbon electrode in sulfuric acid using rotating-disc electrode and cyclic voltammetry. The kinetics of the V(IV)/V(V) redox couple reaction was found to be electrochemically quasi-reversible with the slower kinetics for the V(V) reduction than that for the V(IV) oxidation. And, dependence of diffusion coefficients and kinetic parameters of V(IV) species on the V(IV) and H25O4 concentration was investigated. It is shown that the concentration of active species V(IV)centration, the diffusion coefficients of V(IV) were gradually reduced whereas its kinetics was improved considerably,espicially in the case of Ⅴ(Ⅳ)and H2SO4 up to 2 and 4 mol·L-1.

  2. Foreign Trip Report MATGEN-IV Sep 24- Oct 26, 2007

    de Caro, M S

    2007-10-30

    Gen-IV activities in France, Japan and US focus on the development of new structural materials for Gen-IV nuclear reactors. Oxide dispersion strengthened (ODS) F/M steels have raised considerable interest in nuclear applications. Promising collaborations can be established seeking fundamental knowledge of relevant Gen-IV ODS steel properties (see attached travel report on MATGEN- IV 'Materials for Generation IV Nuclear Reactors'). Major highlights refer to results on future Ferritic/Martensitic steel cladding candidates (relevant to Gen-IV materials properties for LFR Materials Program) and on thermodynamic and mechanic behavior of metallic FeCr binary alloys, base matrix for future candidate steels (for the LLNL-LDRD project on Critical Issues on Materials for Gen-IV Reactors).

  3. PENURUNAN NILAI COD PADA PESTISIDA SIPERMETRIN DENGAN FOTOKATALIS TITANIUM(IV OKSIDA-PLATINA

    Diana Rakhmawaty Eddy

    2014-11-01

    Full Text Available Pada penelitian ini telah dilakukan fotodegradasi pestisida jenis sipermetrin dengan adanya fotokatalis titanium (IV oksida-platina. Fotokatalis tersebut dibuat dengan merefluks larutan titanium(IV oksida tetraminplatina(II klorida selama 2 jam kemudian diuapkan pelarutnya dan dipanaskan selama 12 jam. Padatan fotokatalis kemudian dikalsinasi selama 3 jam pada 500 °C. Hasil sintesis titanium(IV oksida-platina 0,5% dan 1% dikarakterisasi dengan XRD, SEM, dan SEM-EDX. Kemampuan dalam mengkatalisis fotodegradasi diuji untuk pestisida sipermetrin yang dilakukan selama 4 jam. Hasil fotodegradasi dinyatakan sebagai COD (Chemical Oxygen Demand yang diukur setiap 1 jam. Penurunan COD terbesar untuk titanium(IV oksida platina 0,5% dan titanium(IV oksida-platina 1% masing-masing yaitu 77% dan 79%. Sementara TiO2 standar sebesar 68,42 %. Fotokatalis titanium(IV oksida-platina lebih baik dibanding titanium(IV oksida untuk degradasi sipermetrin.

  4. Advanced Clinical Interpretation of the WAIS-IV and WMS-IV: Prevalence of Low Scores Varies by Level of Intelligence and Years of Education

    Brooks, Brian L.; Holdnack, James A.; Iverson, Grant L.

    2011-01-01

    Clinicians can use the base rates of low scores in healthy people to reduce the likelihood of misdiagnosing cognitive impairment. In the present study, base rates were developed for the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) and Wechsler Memory Scale-Fourth Edition (WMS-IV) using 900 healthy adults and validated on 28 patients…

  5. Independent Examination of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV): What Does the WAIS-IV Measure?

    Benson, Nicholas; Hulac, David M.; Kranzler, John H.

    2010-01-01

    Published empirical evidence for the Wechsler Adult Intelligence Scale--Fourth Edition (WAIS-IV) does not address some essential questions pertaining to the applied practice of intellectual assessment. In this study, the structure and cross-age invariance of the latest WAIS-IV revision were examined to (a) elucidate the nature of the constructs…

  6. WAIS-IV and WISC-IV Structural Validity: Alternate Methods, Alternate Results. Commentary on Weiss et al. (2013a) and Weiss et al. (2013b)

    Canivez, Gary L.; Kush, Joseph C.

    2013-01-01

    Weiss, Keith, Zhu, and Chen (2013a) and Weiss, Keith, Zhu, and Chen (2013b), this issue, report examinations of the factor structure of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) and Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV), respectively; comparing Wechsler Hierarchical Model (W-HM) and…

  7. Brief Report: Interrater Reliability of Clinical Diagnosis and DSM-IV Criteria for Autistic Disorder: Results of the DSM-IV Autism Field Trial.

    Klin, Ami; Lang, Jason; Cicchetti, Domenic V.; Volkmar, Fred R.

    2000-01-01

    This study examined the inter-rater reliability of clinician-assigned diagnosis of autism using or not using the criteria specified in the Diagnostic and Statistical Manual IV (DSM-IV). For experienced raters there was little difference in reliability in the two conditions. However, a clinically significant improvement in diagnostic reliability…

  8. Two mutations in the IV/S4-S5 segment of the human skeletal muscle Na+ channel disrupt fast and enhance slow inactivation.

    Alekov, A K; Peter, W; Mitrovic, N; Lehmann-Horn, F; Lerche, H

    2001-06-29

    Fast and slow inactivation (FI, SI) of the voltage-gated Na+ channel are two kinetically distinct and structurally dissociated processes. The voltage sensor IV/S4 and the intracellular IV/S4-S5 loop have been shown to play an important role in FI mediating the coupling between activation and inactivation. Two mutations in IV/S4-S5 of the human muscle Na+ channel, L1482C/A, disrupt FI by inducing a persistent Na+ current, shifting steady-state inactivation in the depolarizing direction and accelerating its recovery. These effects were more pronounced for L1482A. In contrast, SI of L1482C/A channels was enhanced showing a more complete SI and a 3-fold slowing of its recovery. Effects on SI were more pronounced for L1482C. The results indicate an important role of the IV/S4-S5 loop not only in FI but also in SI of the Na+ channel.

  9. The dependence of C IV broad absorption line properties on accompanying Si IV and Al III absorption: relating quasar-wind ionization levels, kinematics, and column densities

    Filiz Ak, N.; Brandt, W. N.; Schneider, D. P.; Trump, J. R. [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Hall, P. B. [Department of Physics and Astronomy, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3 (Canada); Anderson, S. F. [Astronomy Department, University of Washington, Seattle, WA 98195 (United States); Hamann, F. [Department of Astronomy, University of Florida, Gainesville, FL 32611-2055 (United States); Myers, Adam D. [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82071 (United States); Pâris, I. [Departamento de Astronomía, Universidad de Chile, Casilla 36-D, Santiago (Chile); Petitjean, P. [Institut d' Astrophysique de Paris, Universite Paris 6, F-75014 Paris (France); Ross, Nicholas P. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Shen, Yue [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); York, Don, E-mail: nfilizak@astro.psu.edu [Department of Astronomy and Astrophysics, The University of Chicago, Chicago, IL 60637 (United States)

    2014-08-20

    We consider how the profile and multi-year variability properties of a large sample of C IV Broad Absorption Line (BAL) troughs change when BALs from Si IV and/or Al III are present at corresponding velocities, indicating that the line of sight intercepts at least some lower ionization gas. We derive a number of observational results for C IV BALs separated according to the presence or absence of accompanying lower ionization transitions, including measurements of composite profile shapes, equivalent width (EW), characteristic velocities, composite variation profiles, and EW variability. We also measure the correlations between EW and fractional-EW variability for C IV, Si IV, and Al III. Our measurements reveal the basic correlated changes between ionization level, kinematics, and column density expected in accretion-disk wind models; e.g., lines of sight including lower ionization material generally show deeper and broader C IV troughs that have smaller minimum velocities and that are less variable. Many C IV BALs with no accompanying Si IV or Al III BALs may have only mild or no saturation.

  10. Separation chemistry and clean technique of cerium(IV):A review

    邹丹; 陈继; 李德谦

    2014-01-01

    The separation method of changeable valence RE element of cerium (Ce) was reviewed in this paper. Solvent extraction is the most effective and efficient method to separate Ce(IV) from RE(III), usually accompanied with fluorine (F) and phosphor (P) from bastnaesite and monazite etc. By roast or wet-air oxidation, Ce(III) of bastnaesite and monazite was oxidized into Ce(IV), and Cyanex923 and [A336][P507] have been investigated to co-extract and recover Ce(IV), F and P from H2SO4 leaching liquor, leading to favorable conditions for the subsequent separation of Th(IV) and RE(III). The interaction of Ce(IV) and F and/or P enhances the roasting, leaching and extraction of Ce(IV) due to increasing of the stability of Ce(IV), and the formation of CeF3 and CePO4 after reductive stripping will benefit the utilization of F and P. For dealing with RE ores of high-content Ce, the clean process of oxidation roasting and Ce(IV)-F separation for Sichuan bastnaesite highlights the advantages of Ce(IV) based clean technique, which firstly demonstrates the comprehensive utilization of Ce(IV), Th(IV), F and RE(III) and prevention of environmental pollution from foun-tainhead. A preliminary flowsheet of two-step oxidation and extraction of Ce(IV) for Bayan Obo mixed ores was further proposed to process the oxidation and extraction of Ce(IV) in presence of both F and P, indicating the possibility of similar effects with clean process of Sichuan bastnaesite. Ce(IV) separation chemistry and clean technique will open up new realms for light RE resources utilization, meeting“Emission Standards of Pollutants from Rare Earths Industry”promulgated by China’s Ministry of Environment Protection (MOP) in 2011.

  11. Classification Accuracy of Sequentially Administered WAIS-IV Short Forms.

    Ryan, Joseph J; Kreiner, David S; Gontkovsky, Samuel T; Glass Umfleet, Laura

    2015-01-01

    A Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) short form (SF) may be effective for ruling out subnormal intelligence. To create a useful SF, subtest administration should follow the order prescribed in the manual and, depending upon individual performance, be terminated after completion of 2, 3, 4, or 5 subtests. One hundred and twenty-two patients completed the WAIS-IV. In two analyses, Full-Scale IQs (FSIQs) ≤69 and ≤79 were classified as impairment. Classification accuracy statistics indicated that all SFs using both cutoff scores exceeded the base rate (i.e., 14% and 34%) of subnormal intelligence, with hit rates ranging from 84% to 95%. The FSIQ cutoff of ≤69 had poor sensitivity for detecting impaired intellectual functioning with the 2-, 3-, 4-, and 5-subtest SFs; specificity, positive predictive value (PPV), and negative predictive value (NPV) were excellent for each SF. With the FSIQ cutoff of ≤79, sensitivity was strong to excellent for the 3-, 4-, and 5-subtest SFs as were specificity, PPV, and NPV.

  12. WAIS-IV visual puzzles in a mixed clinical sample.

    Fallows, Robert R; Hilsabeck, Robin C

    2012-01-01

    Little is known about which cognitive functions underlie the new Visual Puzzles subtest of the Wechsler Adult Intelligence Scale - Fourth Edition (WAIS-IV). The purpose of this study was to investigate relationships between Visual Puzzles and common neuropsychological measures in a mixed clinical sample. A total of 44 veterans (75% men) were administered the WAIS-IV as part of a neuropsychological evaluation. Average age was 47.4 years (SD = 11.8), and average education was 13.8 years (SD = 2.3). Correlations were conducted to examine relationships between Visual Puzzles, demographic variables, and neuropsychological measures. Hierarchical regression analysis was used to determine which measures contributed the most variance to Visual Puzzles. Visual Puzzles correlated significantly with measures of visuospatial reasoning, verbal learning and recall, mental flexibility, processing speed, and naming, which accounted for 50% of the variance in Visual Puzzles performance. The results indicate that Visual Puzzles is not a pure measure of visuoperceptual reasoning, at least in a mixed clinical sample, because memory, mental flexibility, processing speed, and language abilities also contribute to successful performance of the task. Thus it may be important to consider other aspects of cognitive functioning when interpreting Visual Puzzles performance.

  13. Impeding 99Tc(IV) mobility in novel waste forms

    Lee, Mal-Soon; Um, Wooyong; Wang, Guohui; Kruger, Albert A.; Lukens, Wayne W.; Rousseau, Roger; Glezakou, Vassiliki-Alexandra

    2016-06-01

    Technetium (99Tc) is an abundant, long-lived radioactive fission product whose mobility in the subsurface is largely governed by its oxidation state. Tc immobilization is crucial for radioactive waste management and environmental remediation. Tc(IV) incorporation in spinels has been proposed as a novel method to increase Tc retention in glass waste forms during vitrification. However, experiments under high-temperature and oxic conditions show reoxidation of Tc(IV) to volatile pertechnetate, Tc(VII). Here we examine this problem with ab initio molecular dynamics simulations and propose that, at elevated temperatures, doping with first row transition metal can significantly enhance Tc retention in magnetite in the order Co>Zn>Ni. Experiments with doped spinels at 700 °C provide quantitative confirmation of the theoretical predictions in the same order. This work highlights the power of modern, state-of-the-art simulations to provide essential insights and generate theory-inspired design criteria of complex materials at elevated temperatures.

  14. Usefulness of WISC-IV in Determining Intellectual Giftedness.

    Molinero, Clara; Mata, Sara; Calero, M Dolores; García-Martín, M Belén; Araque-Cuenca, Arsenio

    2015-08-10

    Several studies question the usefulness of the Wechsler Intelligence Scale for Children (WISC-IV) in determining giftedness due to the importance of speed in some of its subtests, which may penalize children of high intellectual level. This study analyzes the factor structure of the WISC-IV of gifted children based on confirmatory factor analysis. Participants were eighty-seven gifted children from Spain (6-13 years old). Score discrepancies were also examined for the main indexes: Verbal Comprehension, Processing Speed, Working Memory and Perceptual Organization. Results pointed out four models with a good fit from the five models analyzed: a two-factor model according to GAI subscales (RMSEA = .001, p = .84), a four-factor first-order model including main indexes (RMSEA = .05, p = .19), a four-factor model with g as a direct factor (RMSEA = .001, p = .84) and a four-factor model with g as an indirect higher-order factor (RMSEA = .05, p = .13). Discrepancies were found between Verbal Comprehension and Processing Speed, and between Perceptual Organization and Processing Speed. Verbal Comprehension yielded the highest score, whereas the lowest scores were obtained in Processing Speed and Working Memory. These results support the use of this scale in the assessment and diagnosis of Spanish children with a high intellectual level.

  15. Named entity recognition for bacterial Type IV secretion systems.

    Ananiadou, Sophia; Sullivan, Dan; Black, William; Levow, Gina-Anne; Gillespie, Joseph J; Mao, Chunhong; Pyysalo, Sampo; Kolluru, Balakrishna; Tsujii, Junichi; Sobral, Bruno

    2011-03-29

    Research on specialized biological systems is often hampered by a lack of consistent terminology, especially across species. In bacterial Type IV secretion systems genes within one set of orthologs may have over a dozen different names. Classifying research publications based on biological processes, cellular components, molecular functions, and microorganism species should improve the precision and recall of literature searches allowing researchers to keep up with the exponentially growing literature, through resources such as the Pathosystems Resource Integration Center (PATRIC, patricbrc.org). We developed named entity recognition (NER) tools for four entities related to Type IV secretion systems: 1) bacteria names, 2) biological processes, 3) molecular functions, and 4) cellular components. These four entities are important to pathogenesis and virulence research but have received less attention than other entities, e.g., genes and proteins. Based on an annotated corpus, large domain terminological resources, and machine learning techniques, we developed recognizers for these entities. High accuracy rates (>80%) are achieved for bacteria, biological processes, and molecular function. Contrastive experiments highlighted the effectiveness of alternate recognition strategies; results of term extraction on contrasting document sets demonstrated the utility of these classes for identifying T4SS-related documents.

  16. Named entity recognition for bacterial Type IV secretion systems.

    Sophia Ananiadou

    Full Text Available Research on specialized biological systems is often hampered by a lack of consistent terminology, especially across species. In bacterial Type IV secretion systems genes within one set of orthologs may have over a dozen different names. Classifying research publications based on biological processes, cellular components, molecular functions, and microorganism species should improve the precision and recall of literature searches allowing researchers to keep up with the exponentially growing literature, through resources such as the Pathosystems Resource Integration Center (PATRIC, patricbrc.org. We developed named entity recognition (NER tools for four entities related to Type IV secretion systems: 1 bacteria names, 2 biological processes, 3 molecular functions, and 4 cellular components. These four entities are important to pathogenesis and virulence research but have received less attention than other entities, e.g., genes and proteins. Based on an annotated corpus, large domain terminological resources, and machine learning techniques, we developed recognizers for these entities. High accuracy rates (>80% are achieved for bacteria, biological processes, and molecular function. Contrastive experiments highlighted the effectiveness of alternate recognition strategies; results of term extraction on contrasting document sets demonstrated the utility of these classes for identifying T4SS-related documents.

  17. DISCOURSE REPRESENTATION OF HOMOSEXUALITY IN THE SYSTEM DSM IV

    Fernanda Téllez Vega

    2015-04-01

    Full Text Available The objective of this study is to highlight the construction and discursive significance that the DSM IV system gives to the homosexuality, considering that the meaning alludes to the internal content of the speech and the significance concerns the external (visible content of the speech. Research methodology focuses on the analysis of contents: discussion, critiques and description of the construction method of the diagnosis manual of mental illnesses in its fourth review. The technique applied was the analysis of contents: identification of the dominant speech, style forms and evaluation of significants. The results showed that the dominant form of the speech is institutional, by the non-discursive neosexual forms. In addition, there is no evidence of changes in the psychiatric speech because its method of construction is circular feedback, that is to say, in any place of the process, homosexuality will be considered as a disorder or as a topic of psychiatric review. The research reveals that the DSM IV system fits to the discursive construction being able-knowing, widely documented by Foucault in which dominant speech exerts power on the neo-sexualities and defines them in an exercise of knowing, registering them in a diagnosis manual.

  18. Characterisation and thermal decomposition of zirconium (IV) soaps

    Varma, R.P. [Dept. of Chemistry, D.A.V. College, Muzaffarnagar (India); Singh, H. [Meerut Univ. (India); Sharma, K.R. [Meerut Univ. (India); Goel, H. [Dept. of Chemistry, D.A.V. College, Muzaffarnagar (India)

    1997-05-01

    Zirconium (IV) soaps of butyric, valeric and stearic acid were prepared and characterised by infrared spectroscopy. Thermal decomposition was studied by dynamic thermogravimetry and differential thermometry in the temperature range of 200-800 C. The order of decomposition was found to be zero for all soaps. The activation energies {Delta}E were found to be: 8.233, 8.620 and 7.181 kJ mol{sup -1} for butyrate, valerate and stearate respectively. The frequency factor, Z, entropy change {Delta}S and free energy change {Delta}G were calculated and a probable decomposition mechanism proposed. (orig.) [Deutsch] Aus Butter-, Valerian- und Stearinsaeure wurden die entsprechenden Zirconium(IV)seifen hergestellt und durch ihre Infrarotspektren charakterisiert. Ihre thermische Zersetzung wurde mittels dynamischer Thermogravimetrie und Differentialthermometrie im Bereich von 200-800 C untersucht. Die Zersetzungsreaktion war fuer alle untersuchten Seifen von nullter Ordnung. Fuer die Aktivierungsenergien, {Delta}E, wurden Werte von 8,233, 8,620 und 7,181 kJ mol{sup -1} fuer Butyrat, Valerat bzw. Stearat gefunden. Der Frequenzfaktor Z, die Entropieaenderung {Delta}S und die Aenderung der freien Energie {Delta}G werden berechnet, und es wird ein moeglicher Mechanismus fuer die Zersetzung angegeben. (orig.)

  19. Retention of composite resin restorations in class IV preparations.

    Eid, Hani

    2002-01-01

    Clinicians often utilized composite resin restorations in combination with different types of preparation to restore class IV fractures on anterior incisors. A new preparation technique called (stair-step chamfer technique) is investigated in this study to detect bond strength to tooth structure. Eighty-eight bovine teeth were divided into 4 groups. Group I had twenty-three samples with a 45 degree bevel that extended 2 millimeters beyond the fracture line. Group II had twenty-three samples with a circumferential chamfer, which extended 2 mm beyond the fracture line and half the enamel thickness in depth. Group III had twenty-three samples with a facial stair-step chamfer, which followed the anatomical contour and extended 2 mm beyond the fracture line with a lingual plain chamfer. Group IV had eighteen samples as controls, which were untreated teeth. The first three groups were prepared and restored with hybrid composite resin in conjunction with a single step bonding agent and as surface penetrating sealer, then tested for shear-bond strength on the Instron machine. The results were that there was no significant difference found between the treated teeth when tested for shear-bond strength. However, according to the site of the fracture, the stair-step chamfer technique gave significantly better results. It can be concluded that, the stir-step chamfer technique provides the clinician better environment to place a composite resin restoration resulting in good shear-bond strength and better esthetics.

  20. Dynamics of gonococcal type IV pili during infection.

    Opitz, Dirk; Clausen, Martin; Maier, Berenike

    2009-07-13

    Type IV pili are important bacterial virulence factors that mediate attachment to mammalian host cells and elicit downstream signals. When adhered to abiotic surfaces, the human pathogen Neisseria gonorrhoeae generates force by retracting these polymeric cell appendages. We recently found that single pili generate stalling forces that exceed 100 pN, but it is unclear whether bacteria generate force once they adhere to their human host cells. Here, we report that pili retract very actively during infection of human epithelial cells. The retraction velocity is bimodal and the high velocity mode persisted at higher forces in contrast to an abiotic environment. Bacteria generate considerable force during infection, but the maximum force is reduced from 120+/-40 pN on abiotic surfaces to 70+/-20 pN on epithelial cells, most likely due to elastic effects. Velocity and maximum force of pilus retraction are largely independent of the infection period within 1 h and 24 h post-infection. Thus, the force generated by type IV pili during infection is high enough to induce cytoskeletal rearrangements in the host cell.

  1. Andromeda IV, a solitary gas-rich dwarf galaxy

    Karachentsev, I D; Tully, R B; Makarova, L N; Sharina, M E; Begum, A; Rizzi, L

    2015-01-01

    Observations are presented of the isolated dwarf irregular galaxy And IV made with the Hubble Space Telescope Advanced Camera for Surveys and the Giant Metrewave Radio Telescope in the 21 cm HI line. We determine the galaxy distance of $7.17\\pm0.31$ Mpc using the Tip of Red Giant Branch method. The galaxy has a total blue absolute magnitude of -12.81 mag, linear Holmberg diameter of 1.88 kpc and an HI-disk extending to 8.4 times the optical Holmberg radius. The HI mass-to-blue luminosity ratio for And IV amounts $12.9~M_{\\odot}/L_{\\odot}$. From the GMRT data we derive the rotation curve for the HI and fit it with different mass models. We find that the data are significantly better fit with an iso-thermal dark matter halo, than by an NFW halo. We also find that MOND rotation curve provides a very poor fit to the data. The fact that the iso-thermal dark matter halo provides the best fit to the data supports models in which star formation feedback results in the formation of a dark matter core in dwarf galaxies...

  2. Impeding 99Tc(IV) mobility in novel waste forms

    Lee, Mal Soon; Um, Wooyong; Wang, Guohui; Kruger, Albert A.; Lukens, Wayne W.; Rousseau, Roger J.; Glezakou, Vassiliki Alexandra

    2016-06-30

    Technetium (99Tc) is a long-lived radioactive fission product whose mobility in the subsurface is largely governed by its oxidation state1. Immobilization of Tc in mineral substrates is crucial for radioactive waste management and environmental remediation. Tc(IV) incorporation in spinels2, 3 has been proposed as a novel method to increase Tc retention in glass waste forms. However, experiments with Tc-magnetite under high temperature and oxic conditions showed re-oxidation of Tc(IV) to volatile pertechnetate Tc(VII)O4-.4, 5 Here we address this problem with large-scale ab initio molecular dynamics simulations and propose that elevated temperatures, 1st row transition metal dopants can significantly enhance Tc retention in the order Co > Zn > Ni. Experiments with doped spinels at T=700 ºC provided quantitative confirmation of increased Tc retention in the same order predicted by theory. This work highlights the power of modern state-of-the-art simulations to provide essential insights and generate bottom-up design criteria of complex oxide materials at elevated temperatures.

  3. SDSS-IV/MaNGA: Spectrophotometric Calibration Technique

    Yan, Renbin; Bershady, Matthew A; Law, David R; Schlegel, David J; Bundy, Kevin; Drory, Niv; MacDonald, Nicholas; Bizyaev, Dmitry; Blanc, Guillermo A; Blanton, Michael R; Cherinka, Brian; Eigenbrot, Arthur; Gunn, James E; Harding, Paul; Hogg, David W; Sánchez-Gallego, José R; Sánchez, Sebastian F; Wake, David A; Weijmans, Anne-Marie; Xiao, Ting; Zhang, Kai

    2015-01-01

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA), one of three core programs in the Sloan Digital Sky Survey-IV (SDSS-IV), is an integral-field spectroscopic (IFS) survey of roughly 10,000 nearby galaxies. It employs dithered observations using 17 hexagonal bundles of 2 arcsec fibers to obtain resolved spectroscopy over a wide wavelength range of 3,600-10,300A. To map the internal variations within each galaxy, we need to perform accurate {\\it spectral surface photometry}, which is to calibrate the specific intensity at every spatial location sampled by each individual aperture element of the integral field unit. The calibration must correct only for the flux loss due to atmospheric throughput and the instrument response, but not for losses due to the finite geometry of the fiber aperture. This requires the use of standard star measurements to strictly separate these two flux loss factors (throughput versus geometry), a difficult challenge with standard single-fiber spectroscopy techniques due to v...

  4. Candidates of Halpha emitting regions in Magellanic Stream IV cloud

    Yagi, Masafumi; Yoshida, Michitoshi

    2012-01-01

    From H\\alpha narrow band observations, we identified three H\\alpha emitting regions in the direction of Magellanic Stream IV (MS IV). They consist of three parallel filaments with 2 arcmin width and 6 -- 30 arcmin length at 12 arcmin intervals. The mean surface brightness of them is $\\sim 2 \\times 10^{-18}$ erg s$^{-1}$ cm$^{-2}$ arcsec$^{-2}$. Because of their low surface brightness, the regions were not detected in previous H\\alpha surveys. In HI map, the position of the filaments overlap MS, suggesting that they are parts of MS, but there also exists a local HI structure. If the filaments associate with MS, the sizes are 30 pc $\\times$ 100 -- 500 pc. The filaments lie at the leading edge of a downstream cloud, which supports a shock heating and its propagation (shock cascade) model for the ionizing source. If they are local objects, on the other hand, Fossil Str\\"omgren Trails of more than two stars is a possible interpretation, and the sizes would be 0.1 pc $\\times$ 0.3 -- 1.5 pc at 180 pc distance. The p...

  5. Particulate emissions from new heavy duty vehicles (Euro IV and V); Partikeludslip fra nye tunge koeretoejer (Euronorm IV og V)

    Jordal-Joergensen, J.; Ohm, A.; Willumsen, E. (COWI A/S, Kgs. Lyngby (DK))

    2008-07-01

    The new Danish act on environmental zones allows local authorities to define zones where EURO III or older heavy duty vehicles should be equipped with a particulate filter. The introduction of EURO IV and V has reduced particulate emissions from heavy duty vehicles by approximately 80 % based on the mass of particles. There is, however, substantial uncertainty about the impact on the number of ultrafine particles, since they are not covered by Euronorm standards. When passing the bill, the Danish Minister for the Environment of the time stated that all relevant knowledge about particle emission from heavy duty vehicles needed to be collected for subsequent publication. To this end, the Danish Environmental Protection Agency (DEPA) commissioned a literature survey. The purpose of the survey is to provide an overview of the latest knowledge in the field of particle emissions from heavy duty vehicles, with special focus on the average size of the particle emissions. Another objective of the study is to analyse the direct emissions of NO{sub 2} from heavy duty vehicles classified under EURO IV and V. (au)

  6. Astragaloside IV enhances diabetic wound healing involving upregulation of alternatively activated macrophages.

    Luo, Xiaochun; Huang, Ping; Yuan, Baohong; Liu, Tao; Lan, Fang; Lu, Xiaoyan; Dai, Liangcheng; Liu, Yunjun; Yin, Hui

    2016-06-01

    Astragaloside IV (AS-IV), one of the major active compounds extracted from Astragali Radix, has been used experimentally for its potent antiinflammatory and immunoregulatory activities. In this study, we further investigate the potential efficacy of AS-IV on impaired wound healing in streptozotocin-induced diabetic mice. A full-thickness skin wound was produced on the back of diabetic mice and treated with AS-IV or vehicle topically. Our results showed that AS-IV application promoted diabetic wound repair with wounds gaping narrower and exhibiting augmented reepithelialization. AS-IV enhanced the collagen deposition and the expression of extracellular matrix (ECM)-related genes such as fibronectin and collagen IIIa, which implies a direct effect of AS-IV on matrix synthesis. AS-IV also improved the new blood vessel formation in wound tissue with increased numbers of endothelial cells and enhanced expression of VEGF and vWF. Moreover, the beneficial effect of AS-IV was related to the development of polarized alternatively activated macrophages, which involved in resolution of inflammation and facilitation of wound repair. All together, these findings suggest that AS-IV may play a potential effect on maintenance of cutaneous homeostasis and acceleration of diabetic wound healing.

  7. Supporting Technology for Enhanced Oil Recovery-EOR Thermal Processes Report IV-12

    Izequeido, Alexandor

    2001-04-01

    This report contains the results of efforts under the six tasks of the Ninth Amendment and Extension of Annex IV, Enhanced Oil Recovery Thermal Processes of the Venezuela/USA Agreement. The report is presented in sections (for each of the 6 tasks) and each section contains one or more reports prepared by various individuals or groups describing the results of efforts under each of the tasks. A statement of each task, taken from the agreement, is presented on the first page of each section. The tasks are numbered 62 through 67. The first, second, third, fourth, fifth, sixth, seventh, eight, and ninth reports on Annex IV, [Venezuela MEM/USA-DOE Fossil Energy Report IV-1, IV-2, IV-3, IV-4, IV-5, IV-6, IV-7, and IV-8 (DOE/BETC/SP-83/15, DOE/BC-84/6/SP, DOE/BC-86/2/SP, DOE/BC-87/2/SP, DOE/BC-89/1/SP, DOE/BC-90/1/SP) DOE/BC-92/1/SP, DOE/BC-93/3/SP, and DOE/BC-95/3/SP] contain the results from the first 61 tasks. Those reports are dated April 1983, August 1984, March 1986, July 1! 987, November 1988, December 1989, October 1991, February 1993, and March 1995 respectively.

  8. Central administration of angiotensin IV rapidly enhances novel object recognition among mice.

    Paris, Jason J; Eans, Shainnel O; Mizrachi, Elisa; Reilley, Kate J; Ganno, Michelle L; McLaughlin, Jay P

    2013-07-01

    Angiotensin IV (Val(1)-Tyr(2)-Ile(3)-His(4)-Pro(5)-Phe(6)) has demonstrated potential cognitive-enhancing effects. The present investigation assessed and characterized: (1) dose-dependency of angiotensin IV's cognitive enhancement in a C57BL/6J mouse model of novel object recognition, (2) the time-course for these effects, (3) the identity of residues in the hexapeptide important to these effects and (4) the necessity of actions at angiotensin IV receptors for procognitive activity. Assessment of C57BL/6J mice in a novel object recognition task demonstrated that prior administration of angiotensin IV (0.1, 1.0, or 10.0, but not 0.01 nmol, i.c.v.) significantly enhanced novel object recognition in a dose-dependent manner. These effects were time dependent, with improved novel object recognition observed when angiotensin IV (0.1 nmol, i.c.v.) was administered 10 or 20, but not 30 min prior to the onset of the novel object recognition testing. An alanine scan of the angiotensin IV peptide revealed that replacement of the Val(1), Ile(3), His(4), or Phe(6) residues with Ala attenuated peptide-induced improvements in novel object recognition, whereas Tyr(2) or Pro(5) replacement did not significantly affect performance. Administration of the angiotensin IV receptor antagonist, divalinal-Ang IV (20 nmol, i.c.v.), reduced (but did not abolish) novel object recognition; however, this antagonist completely blocked the procognitive effects of angiotensin IV (0.1 nmol, i.c.v.) in this task. Rotorod testing demonstrated no locomotor effects with any angiotensin IV or divalinal-Ang IV dose tested. These data demonstrate that angiotensin IV produces a rapid enhancement of associative learning and memory performance in a mouse model that was dependent on the angiotensin IV receptor.

  9. 78 FR 32294 - DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P., License No. 02/02-0662,02/02...

    2013-05-29

    ... ADMINISTRATION DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P., License No. 02/02-0662,02/02-0661; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that DeltaPoint Capital IV, L.P. and DeltaPoint Capital IV (New York),...

  10. DPP-IV-resistant, long-acting oxyntomodulin derivatives.

    Santoprete, Alessia; Capitò, Elena; Carrington, Paul E; Pocai, Alessandro; Finotto, Marco; Langella, Annunziata; Ingallinella, Paolo; Zytko, Karolina; Bufali, Simone; Cianetti, Simona; Veneziano, Maria; Bonelli, Fabio; Zhu, Lan; Monteagudo, Edith; Marsh, Donald J; Sinharoy, Ranabir; Bianchi, Elisabetta; Pessi, Antonello

    2011-04-01

    Obesity is one of the major risk factors for type 2 diabetes, and the development of agents, that can simultaneously achieve glucose control and weight loss, is being actively pursued. Therapies based on peptide mimetics of the gut hormone glucagon-like peptide 1 (GLP-1) are rapidly gaining favor, due to their ability to increase insulin secretion in a strictly glucose-dependent manner, with little or no risk of hypoglycemia, and to their additional benefit of causing a modest, but durable weight loss. Oxyntomodulin (OXM), a 37-amino acid peptide hormone of the glucagon (GCG) family with dual agonistic activity on both the GLP-1 (GLP1R) and the GCG (GCGR) receptors, has been shown to reduce food intake and body weight in humans, with a lower incidence of treatment-associated nausea than GLP-1 mimetics. As for other peptide hormones, its clinical application is limited by the short circulatory half-life, a major component of which is cleavage by the enzyme dipeptidyl peptidase IV (DPP-IV). SAR studies on OXM, described herein, led to the identification of molecules resistant to DPP-IV degradation, with increased potency as compared to the natural hormone. Analogs derivatized with a cholesterol moiety display increased duration of action in vivo. Moreover, we identified a single substitution which can change the OXM pharmacological profile from a dual GLP1R/GCGR agonist to a selective GLP1R agonist. The latter finding enabled studies, described in detail in a separate study (Pocai A, Carrington PE, Adams JR, Wright M, Eiermann G, Zhu L, Du X, Petrov A, Lassman ME, Jiang G, Liu F, Miller C, Tota LM, Zhou G, Zhang X, Sountis MM, Santoprete A, Capitò E, Chicchi GG, Thornberry N, Bianchi E, Pessi A, Marsh DJ, SinhaRoy R. Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice. Diabetes 2009; 58: 2258-2266), which highlight the potential of GLP1R/GCGR dual agonists as a potentially superior class of therapeutics over the pure GLP1R agonists

  11. The α2 helix in the DNA ligase IV BRCT-1 domain is required for targeted degradation of ligase IV during adenovirus infection.

    Gilson, Timra; Greer, Amy E; Vindigni, Alessandro; Ketner, Gary; Hanakahi, Leslyn A

    2012-07-05

    In adenovirus E4 mutant infections, viral DNAs form concatemers through a process that requires host Non-homologous End Joining (NHEJ) proteins including DNA Ligase IV (LigIV). Adenovirus proteins E4 34k and E1b 55k form the substrate-selection component of an E3 ubiquitin ligase and prevent concatenation by targeting LigIV for proteasomal degradation. The mechanisms and sites involved in targeting this and other E3 ligase substrates generally are poorly-understood. Through genetic analysis, we identified the α2 helix of one LigIV BRCT domain (BRCT-1) as essential for adenovirus-mediated degradation. Replacement of the BRCT domain of DNA ligase III (LigIII), which is resistant to degradation, with LigIV BRCT-1 does not promote degradation. A humanized mouse LigIV that possesses a BRCT-1 α2 helix identical to the human protein, like its parent, is also resistant to adenovirus-mediated degradation. Thus, both the BRCT-1 α2 helix and an element outside BRCT-1 are required for adenovirus-mediated degradation of LigIV.

  12. ROLE OF PALLIATION IN STAGE IV CARCINOMA CERVIX

    Smriti

    2013-03-01

    Full Text Available ABSTRACT: BACKGROUND: Palliation reduces the severity of disease symptoms, rather than reversing its progression or providing a cure. Metast atic cancer cervix (Ca Cx is incurable by surgery, radiation or chemotherapy, but these modali ties are useful for palliation. Globally about five to six lakh new cases of carcinoma cervi x are diagnosed every year. Of these, one lakh cases are diagnosed in India of which 25.0% are fro m West Bengal only. OBJECTIVES: Our objective was to study the role of palliation in Sta ge IV Carcinoma Cervix. SETTINGS AND DESIGN: During the study period of five years from January 2 007 to December 2011, consecutive seventy five new cases of stage IV carc inoma cervix diagnosed at Netaji Subhas Chandra Bose Cancer Research Institute, Kolkata, we re included in our study. MATERIALS AND METHODS: Clinical examination with relevant investigations l ike kidney function tests (KFT, biopsy, cystoscopy, CT scan etc were done for diagno sis & staging. Treatment was decided based on woman's age, general health and the locati on & type of the tumour. Treatment options were surgery, radiotherapy (RT, chemotherapy (CT an d simple palliation. In our study, combined CT+RT was done in 18.67% patients most of w ho presented with Stage IV disease. Radiation was given as brachytherapy following telet herapy. Chemotherapy was used as adjunct to RT or for palliation or as neo-adjuvant c hemotherapy (NACT, most commonly using paclitaxel (135mg/square metre, cisplatin (50mg/ squ are metre and 5- fluorouracil (600mg/ square metre. At times, chemotherapy could provide pa in relief only. Vault smear and metastatic workup was done during follow-up visits ev ery 8-12 weeks after treatment completion. RESULTS: Majority of patients belonged to the age group 42-69 years with a median age of 53 years. Bladder involvement was see n in 15(20.0% cases, bowel involvement in 14(19.0% and distant metastasis in 46(61.0% ca ses. Most cases were of Squamous

  13. Introduction to The neurosciences and music IV: learning and memory.

    Altenmüller, E; Demorest, S M; Fujioka, T; Halpern, A R; Hannon, E E; Loui, P; Majno, M; Oechslin, M S; Osborne, N; Overy, K; Palmer, C; Peretz, I; Pfordresher, P Q; Särkämö, T; Wan, C Y; Zatorre, R J

    2012-04-01

    The conference entitled "The Neurosciences and Music-IV: Learning and Memory'' was held at the University of Edinburgh from June 9-12, 2011, jointly hosted by the Mariani Foundation and the Institute for Music in Human and Social Development, and involving nearly 500 international delegates. Two opening workshops, three large and vibrant poster sessions, and nine invited symposia introduced a diverse range of recent research findings and discussed current research directions. Here, the proceedings are introduced by the workshop and symposia leaders on topics including working with children, rhythm perception, language processing, cultural learning, memory, musical imagery, neural plasticity, stroke rehabilitation, autism, and amusia. The rich diversity of the interdisciplinary research presented suggests that the future of music neuroscience looks both exciting and promising, and that important implications for music rehabilitation and therapy are being discovered.

  14. IV Seminario de Investigación Doctoral

    Álvarez Falcón, César

    2014-01-01

    El 26 de Septiembre del año 2008 se llevó a cabo el IV Seminario de Investigación Doctoral organizado por el Área de Investigaciones y el Centro de Información de la Escuela de Postgrado. El objetivo de este seminario fue orientar y lograr que el doctorando esté en condiciones de elaborar su plan de tesis con énfasis en la selección de bibliografía de calidad a través del uso de herramientas digitales que la EPG y sus redes institucionales brindan a los doctorandos. El evento comenzó con l...

  15. CRR/CRD IV: the trees and the forest

    Rainer Masera

    2014-12-01

    Full Text Available This paper offers a review of the new CRR/CRD IV capital regulatory framework for banks in the EU, which represents the transposition into European law of the Basel III standard. Major shortcomings of the Second Capital Accord are examined, and the repair work is assessed in the light of the recognised need to amend the flaws. It is argued that the necessary adjustments must be evaluated in the holistic framework provided by the Banking Union approach. The main features of the new system are reviewed as components of an interconnected, complex network. The critical analysis highlights the significant improvements with respect to the Basel II standard, but it also brings to the fore the weaknesses which continue to characterise the new capital regulatory framework.

  16. Mechanical stability study of type IV cryomodule (ILC prototype)

    McGee, M.W.; Doremus, R.; Wands, C.R.; /Fermilab

    2007-06-01

    An ANSYS modal and harmonic finite element analysis (FEA) was performed in order to investigate cryomodule design mechanical stability for the proposed International Linear Collider (ILC). The current cryomodule, designated Type IV or (T4CM), closely follows the Type III TESLA Test Facility (TTF) version used at DESY, with the exception of a proposed location of the superconducting (SC) quadrupole at the center. This analysis considered the stringent stability criteria established for the ILC, where vertical motion for the SC quadrupole is limited to the micron range at a few Hz. Model validation was achieved through Type III cryomodule vibration measurement studies performed at DESY. The effect of support location, support stiffness and other important parameters were considered in a parametric sensitivity study. FEA results, fast motion investigations and stabilization techniques are discussed.

  17. Bis(ethyleneglycolato-κ2O,O′tellurium(IV

    Neil R. Brooks

    2013-07-01

    Full Text Available The title compound, C4H8O4Te, crystallized from a solution of Te4+ in ethylene glycol. The TeIV atom is in a distorted seesaw coordination defined by four O atoms from two different ethyleneglycate ligands. The C atoms of the ethyleneglycate ligands are disorderd over two positions, with population parameters of 50.3 (6 and 49.7 (6% indicating a statistical distribution. Due to the possibility to transform the primitive monoclinic unit cell into a metrically orthorhombic C unit cell, the data are twinned and were refined with the twin law -100/0-10/101 with the relative scale factor refining to 1.82 (4% for the minor component.

  18. Synthesis and characterization of oxovanadium (IV dithiocarbamates with pyridine

    Antonio L. Doadrio

    2002-07-01

    Full Text Available We report the synthesis and study of a new series of oxovanadium (IV dithiocarbamate adducts and derivatives with pyridine and cyclohexyl, di-iso-butyl, di-n-propyl, anilin, morpholin, piperidin and di-iso-propyl amines. The complexes have been characterized by analytical, magnetochemical, IR, visible-UV spectral and thermal studies, and are assigned the formulas [VO(L2].py, where L=cyclohexyl, di-iso-butyl, di-n-propyl, anilin dithiocarbamate and [VO(OH(L(py2]OH.H2O (L=morpholin, piperidin and di-iso-propyl dithiocarbamate. The effect of the adduct formation on the pV=0 bound is discussed in terms of the IR (V=O, V-S and V-N stretching frequencies and electronic spectra (d-d transitions.

  19. Les jeux de l’injure dans Henry IV

    Vienne-Guerrin, Nathalie

    2006-01-01

    International audience; Il s’agit d’analyser les mécanismes ludiques qui président aux « joutes de jactance » qui sont si caractéristiques d’Henry iv et à l’aune desquelles on peut mesurer l’ambiguïté et l’évolution de la relation entre Falstaff et Hal / Henry. Nous examinons comment ces tournois d’injures se manifestent sur la scène shakespearienne. Il ne s’agit pas d’une étude rhétorique et lexicale de l’injure mais de l’examen d’un rituel verbal paradoxal au cours duquel on s’insulte sans ...

  20. ACME-III and ACME-IV Final Campaign Reports

    Biraud, S. C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2016-01-01

    The goals of the Atmospheric Radiation Measurement (ARM) Climate Research Facility’s third and fourth Airborne Carbon Measurements (ACME) field campaigns, ACME-III and ACME-IV, are: 1) to measure and model the exchange of CO2, water vapor, and other greenhouse gases by the natural, agricultural, and industrial ecosystems of the Southern Great Plains (SGP) region; 2) to develop quantitative approaches to relate these local fluxes to the concentration of greenhouse gases measured at the Central Facility tower and in the atmospheric column above the ARM SGP Central Facility, 3) to develop and test bottom-up measurement and modeling approaches to estimate regional scale carbon balances, and 4) to develop and test inverse modeling approaches to estimate regional scale carbon balance and anthropogenic sources over continental regions. Regular soundings of the atmosphere from near the surface into the mid-troposphere are essential for this research.

  1. Organic / IV, III-V Semiconductor Hybrid Solar Cells

    Pang-Leen Ong

    2010-03-01

    Full Text Available We present a review of the emerging class of hybrid solar cells based on organic-semiconductor (Group IV, III-V, nanocomposites, which states separately from dye synthesized, polymer-metal oxides and organic-inorganic (Group II-VI nanocomposite photovoltaics. The structure of such hybrid cell comprises of an organic active material (p-type deposited by coating, printing or spraying technique on the surface of bulk or nanostructured semiconductor (n-type forming a heterojunction between the two materials. Organic components include various photosensitive monomers (e.g., phtalocyanines or porphyrines, conjugated polymers, and carbon nanotubes. Mechanisms of the charge separation at the interface and their transport are discussed. Also, perspectives on the future development of such hybrid cells and comparative analysis with other classes of photovoltaics of third generation are presented.

  2. Nanomembrane-based materials for Group IV semiconductor quantum electronics.

    Paskiewicz, D M; Savage, D E; Holt, M V; Evans, P G; Lagally, M G

    2014-02-27

    Strained-silicon/relaxed-silicon-germanium alloy (strained-Si/SiGe) heterostructures are the foundation of Group IV-element quantum electronics and quantum computation, but current materials quality limits the reliability and thus the achievable performance of devices. In comparison to conventional approaches, single-crystal SiGe nanomembranes are a promising alternative as substrates for the epitaxial growth of these heterostructures. Because the nanomembrane is truly a single crystal, in contrast to the conventional SiGe substrate made by compositionally grading SiGe grown on bulk Si, significant improvements in quantum electronic-device reliability may be expected with nanomembrane substrates. We compare lateral strain inhomogeneities and the local mosaic structure (crystalline tilt) in strained-Si/SiGe heterostructures that we grow on SiGe nanomembranes and on compositionally graded SiGe substrates, with micro-Raman mapping and nanodiffraction, respectively. Significant structural improvements are found using SiGe nanomembranes.

  3. PREPARATION AND CHARACTERIZATION OF SOME SILICON (IV COMPLEXES

    Z.F DAWOOD

    2008-06-01

    Full Text Available Silicon(IV complexes containing mixed ligands: Shiff-bases (AH {derived from 2- or 3- amino-pyridine with 2-hydroxy- or 3-me- thoxy- or 2-hydroxy-3-methoxy-benzaldehyde} and benzalde- hyde semicarbazone (BSCH, have been prepared. The resulted complexes have been characterized by elemental analysis, molar conductance values, infrared and electronic spectral data. Complexes of the type [Si(BSCH2(AH]Cl4, [Si(BSC2(AnH]Cl2 and [Si(BSC2(A]Cl (where n=2 or 3, A=deprotonated Schiff-base ligands , BSC= deprotonated semicarbazone have been proposed in neutral and basic medium, respectively.

  4. Pillared metal(IV) phosphate-phosphonate extraction of actinides

    Burns, J.D.; Clearfield, A. [Texas A and M Univ., College Station, TX (United States). Dept. of Chemistry; Borkowski, M.; Reed, D.T. [Los Alamos National Laboratory, Carlsbad, NM (United States). Earth and Environmental Sciences Div.

    2012-07-01

    Four pillared metal(IV) phosphate-phosphonate ion exchange materials were synthesized and characterized. Studies were conducted to determine their affinity for the lanthanides (Ln's) and actinides (An's). It was determined that by simply manipulating the metal source (Zr or Sn) and the phosphate source (H{sub 3}PO{sub 4} or Na{sub 3}PO{sub 4}) large differences were seen in the extraction of the Ln and An species. K{sub d} values higher than 4 x 10{sup 5} were observed for the AnO{sub 2}{sup 2+} species in nitric acid at pH 2. These basic uptake experiments are important, as the data they provide may indicate the possibility of a separation of Ln's from An's or even more notably americium from curium and Ln's. (orig.)

  5. Reducing bloodstream infection with a chlorhexidine gel IV dressing.

    Jeanes, Annette; Bitmead, James

    The use of vascular access devices (VAD) is common in healthcare provision but there is a significant risk of acquiring an infection. Central venous catheters (CVC) are associated with the highest risk of intravenous catheter-related bloodstream infection (CRBSI). 3M™ Tegaderm™ CHG IV dressing is a semi-permeable transparent adhesive dressing with an integrated gel pad containing chlorhexidine gluconate 2%. This product was reviewed by the National Institute for Health and Care Excellence (NICE) in 2015, recommending that Tegaderm CHG could be used for CVC and arterial line dressings in high-dependency and intensive-care settings. This article discusses issues around CRBSI, interventions to reduce the risk of CRBSI, and the use of Tegaderm CHG dressing.

  6. Chromospheric models for Altair (A7 IV-V)

    Ferrero, R. Freire; Gouttebroze, P.; Catalano, S.; Marilli, E.; Bruhweiler, F.; Kondo, Y.; Van Der Hucht, K.; Talavera, A.

    1995-01-01

    The star, Altair (A7 IV-V), is clearly shown to have Lyman-alpha emission of chromospheric origin, while no evidence is found for the Mg II emission reported in previous investigations. We present non-Local Thermodymanic Equilibrium (non-LTE) semiempirical models incorporating partial redistribution of the chromosphere of Altair that reproduce the observed Lyman-alpha emission and the Mg II resonance absorption at 2800 A. We unambiguously establihed that chromospheres exist at spectral types as early as A7 on the main sequence, and we also demonstrate that it very unlikely that the observed emission originates in a corotating expanding wind. This result represents a new challenge for chromospheric heating theories. It may indicate that both differential rotation and convection layers, at least near the equator, exist in this fast rotating (v sin i = 220 km/s) star.

  7. Mg II & C IV Kinematics vs. Stellar Kinematics in Galaxies

    Churchill, C W; Churchill, Chris; Steidel, Chuck

    2002-01-01

    Comparisons of the kinematics of Mg II absorbing gas and the stellar rotation curves in 0.5 < z < 1.0 spiral galaxies suggests that, at least in some cases, the extended gaseous envelopes may be dynamically coupled to the stellar matter. A strong correlation exists between the overall kinematic spread of Mg II absorbing gas and C IV absorption strength, and therefore kinematics of the higher-ionization gas. Taken together, the data may suggest a "halo/disk connection" between z~1 galaxies and their extended gaseous envelopes. Though the number of galaxies in our sample are few, there are no clear examples that suggest the gas is accreting/infalling isotropically about the galaxies from the intergalactic medium.

  8. DNA ligase IV as a new molecular target for temozolomide

    Kondo, Natsuko [Department of Biology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521 (Japan); Department of Neurosurgery, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521 (Japan); Takahashi, Akihisa; Mori, Eiichiro; Ohnishi, Ken [Department of Biology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521 (Japan); McKinnon, Peter J. [Department of Genetics and Tumor Cell Biology, St. Jude Children' s Research Hospital, Memphis, TN 38105 (United States); Sakaki, Toshisuke; Nakase, Hiroyuki [Department of Neurosurgery, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521 (Japan); Ohnishi, Takeo, E-mail: tohnishi@naramed-u.ac.jp [Department of Biology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521 (Japan)

    2009-10-02

    Temozolomide (TMZ) is a methylating agent used in chemotherapy against glioblastoma. This work was designed to clarify details in repair pathways acting to remove DNA double-strand breaks (DSBs) induced by TMZ. Cultured mouse embryonic fibroblasts were used which were deficient in DSB repair genes such as homologous recombination repair-related genes X-ray repair cross-complementing group 2 (XRCC2)and radiation sensitive mutant54 (Rad54), non-homologous end joining repair-related gene DNAligase IV (Lig4). Cell sensitivity to drug treatments was assessed using colony forming assays. The most effective molecular target which was correlated with TMZ cell sensitivity was Lig4. In addition, it was found that small interference RNAs (siRNA) for Lig4 efficiently enhanced cell lethality induced by TMZ in human glioblastoma A172 cells. These findings suggest that down regulation of Lig4 might provide a useful tool for cell sensitization during TMZ chemotherapy.

  9. Automation Of An I-V Characterization System

    J. R. Noriega

    2010-08-01

    Full Text Available In this paper, an accurate I-V virtual instrument (VI that has been developed to characterize electronic devices forresearch and teaching purposes is demonstrated. The virtual instrument can be used to highlight principles ofmeasurement, instrumentation, fundamental principles of electronics, VI programming, device testing andcharacterization in wafer or discrete device level. It consists of a Keithley electrometer, model 6514, a programmablepower supply BK Precision, model 1770, a Keithley source meter, model 2400-LV, an Agilent digital multimeter, model34401, a PC computer and LabVIEW software. The instruments are interconnected using an IEEE 488 protocol. Thecharacteristic VI devices graphs are generated from measured data previous computational processing. Theinstrument is used in basic courses of physical electronics as well as in advance curses of VLSI design and inresearch work for characterization of semiconductor materials and devices. This paper describes the VI instrumentdesign, implementation and characterization experiments.

  10. Conservation of the Type IV secretion system throughout Wolbachia evolution

    Pichon, Samuel; Bouchon, Didier; Cordaux, Richard;

    2009-01-01

    The Type IV Secretion System (T4SS) is an efficient pathway with which bacteria can mediate the transfer of DNA and/or proteins to eukaryotic cells. In Wolbachia pipientis, a maternally inherited obligate endosymbiont of arthropods and nematodes, two operons of vir genes, virB3-B6 and virB8-D4......, encoding a T4SS were previously identified and characterized at two separate genomic loci. Using the largest data set of Wolbachia strains studied so far, we show that vir gene sequence and organization are strictly conserved among 37 Wolbachia strains inducing various phenotypes such as cytoplasmic...... incompatibility, feminization, or oogenesis in their arthropod hosts. In sharp contrast, extensive variation of genomic sequences flanking the virB8-D4 operon suggested its distinct location among Wolbachia genomes. Long term conservation of the T4SS may imply maintenance of a functional effector translocation...

  11. EFFECTIVE INDEPENDENT QUALITY ASSESSMENT USING IV&V

    K. Nageswara Rao

    2011-06-01

    Full Text Available Software is critical to the effectiveness, competitiveness, and survival of any organization. Unexpected behavior or critical problems that bring operations to an idle are just not an option. Effective oversight is critical to good project management and as it is important for the project manager to ensure that the project is on track and to be completed within the estimated schedule and cost by maintaining the quality of the deliverables. This paper describes the role of Independent Verification and Validation (IV&V integrated into the software development life cycle in bringing down company’s cost to develop software products, improve the quality of developed systems and save money throughout the system life cycle by detecting and identifying risk elements throughout the entire software development process thus allowing project and quality assurance managers to respond quickly in order to mitigate risks earlier in the product development life cycle, with more effectiveness, and with less impact on cost and schedule.

  12. Identification of Anaplasma marginale type IV secretion system effector proteins.

    Svetlana Lockwood

    Full Text Available BACKGROUND: Anaplasma marginale, an obligate intracellular alphaproteobacterium in the order Rickettsiales, is a tick-borne pathogen and the leading cause of anaplasmosis in cattle worldwide. Complete genome sequencing of A. marginale revealed that it has a type IV secretion system (T4SS. The T4SS is one of seven known types of secretion systems utilized by bacteria, with the type III and IV secretion systems particularly prevalent among pathogenic Gram-negative bacteria. The T4SS is predicted to play an important role in the invasion and pathogenesis of A. marginale by translocating effector proteins across its membrane into eukaryotic target cells. However, T4SS effector proteins have not been identified and tested in the laboratory until now. RESULTS: By combining computational methods with phylogenetic analysis and sequence identity searches, we identified a subset of potential T4SS effectors in A. marginale strain St. Maries and chose six for laboratory testing. Four (AM185, AM470, AM705 [AnkA], and AM1141 of these six proteins were translocated in a T4SS-dependent manner using Legionella pneumophila as a reporter system. CONCLUSIONS: The algorithm employed to find T4SS effector proteins in A. marginale identified four such proteins that were verified by laboratory testing. L. pneumophila was shown to work as a model system for A. marginale and thus can be used as a screening tool for A. marginale effector proteins. The first T4SS effector proteins for A. marginale have been identified in this work.

  13. Classification of Liss IV Imagery Using Decision Tree Methods

    Verma, Amit Kumar; Garg, P. K.; Prasad, K. S. Hari; Dadhwal, V. K.

    2016-06-01

    Image classification is a compulsory step in any remote sensing research. Classification uses the spectral information represented by the digital numbers in one or more spectral bands and attempts to classify each individual pixel based on this spectral information. Crop classification is the main concern of remote sensing applications for developing sustainable agriculture system. Vegetation indices computed from satellite images gives a good indication of the presence of vegetation. It is an indicator that describes the greenness, density and health of vegetation. Texture is also an important characteristics which is used to identifying objects or region of interest is an image. This paper illustrate the use of decision tree method to classify the land in to crop land and non-crop land and to classify different crops. In this paper we evaluate the possibility of crop classification using an integrated approach methods based on texture property with different vegetation indices for single date LISS IV sensor 5.8 meter high spatial resolution data. Eleven vegetation indices (NDVI, DVI, GEMI, GNDVI, MSAVI2, NDWI, NG, NR, NNIR, OSAVI and VI green) has been generated using green, red and NIR band and then image is classified using decision tree method. The other approach is used integration of texture feature (mean, variance, kurtosis and skewness) with these vegetation indices. A comparison has been done between these two methods. The results indicate that inclusion of textural feature with vegetation indices can be effectively implemented to produce classifiedmaps with 8.33% higher accuracy for Indian satellite IRS-P6, LISS IV sensor images.

  14. CLASSIFICATION OF LISS IV IMAGERY USING DECISION TREE METHODS

    A. K. Verma

    2016-06-01

    Full Text Available Image classification is a compulsory step in any remote sensing research. Classification uses the spectral information represented by the digital numbers in one or more spectral bands and attempts to classify each individual pixel based on this spectral information. Crop classification is the main concern of remote sensing applications for developing sustainable agriculture system. Vegetation indices computed from satellite images gives a good indication of the presence of vegetation. It is an indicator that describes the greenness, density and health of vegetation. Texture is also an important characteristics which is used to identifying objects or region of interest is an image. This paper illustrate the use of decision tree method to classify the land in to crop land and non-crop land and to classify different crops. In this paper we evaluate the possibility of crop classification using an integrated approach methods based on texture property with different vegetation indices for single date LISS IV sensor 5.8 meter high spatial resolution data. Eleven vegetation indices (NDVI, DVI, GEMI, GNDVI, MSAVI2, NDWI, NG, NR, NNIR, OSAVI and VI green has been generated using green, red and NIR band and then image is classified using decision tree method. The other approach is used integration of texture feature (mean, variance, kurtosis and skewness with these vegetation indices. A comparison has been done between these two methods. The results indicate that inclusion of textural feature with vegetation indices can be effectively implemented to produce classifiedmaps with 8.33% higher accuracy for Indian satellite IRS-P6, LISS IV sensor images.

  15. Group IV nanotube transistors for next generation ubiquitous computing

    Fahad, Hossain M.

    2014-06-04

    Evolution in transistor technology from increasingly large power consuming single gate planar devices to energy efficient multiple gate non-planar ultra-narrow (< 20 nm) fins has enhanced the scaling trend to facilitate doubling performance. However, this performance gain happens at the expense of arraying multiple devices (fins) per operation bit, due to their ultra-narrow dimensions (width) originated limited number of charges to induce appreciable amount of drive current. Additionally arraying degrades device off-state leakage and increases short channel characteristics, resulting in reduced chip level energy-efficiency. In this paper, a novel nanotube device (NTFET) topology based on conventional group IV (Si, SiGe) channel materials is discussed. This device utilizes a core/shell dual gate strategy to capitalize on the volume-inversion properties of an ultra-thin (< 10 nm) group IV nanotube channel to minimize leakage and short channel effects while maximizing performance in an area-efficient manner. It is also shown that the NTFET is capable of providing a higher output drive performance per unit chip area than an array of gate-all-around nanowires, while maintaining the leakage and short channel characteristics similar to that of a single gate-all-around nanowire, the latter being the most superior in terms of electrostatic gate control. In the age of big data and the multitude of devices contributing to the internet of things, the NTFET offers a new transistor topology alternative with maximum benefits from performance-energy efficiency-functionality perspective. © (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

  16. Hereditary sensory and autonomic neuropathies: types II, III, and IV.

    Axelrod, Felicia B; Gold-von Simson, Gabrielle

    2007-10-03

    The hereditary sensory and autonomic neuropathies (HSAN) encompass a number of inherited disorders that are associated with sensory dysfunction (depressed reflexes, altered pain and temperature perception) and varying degrees of autonomic dysfunction (gastroesophageal reflux, postural hypotention, excessive sweating). Subsequent to the numerical classification of four distinct forms of HSAN that was proposed by Dyck and Ohta, additional entities continue to be described, so that identification and classification are ongoing. As a group, the HSAN are rare diseases that affect both sexes. HSAN III is almost exclusive to individuals of Eastern European Jewish extraction, with incidence of 1 per 3600 live births. Several hundred cases with HSAN IV have been reported. The worldwide prevalence of HSAN type II is very low. This review focuses on the description of three of the disorders, HSAN II through IV, that are characterized by autosomal recessive inheritance and onset at birth. These three forms of HSAN have been the most intensively studied, especially familial dysautonomia (Riley-Day syndrome or HSAN III), which is often used as a prototype for comparison to the other HSAN. Each HSAN disorder is likely caused by different genetic errors that affect specific aspects of small fiber neurodevelopment, which result in variable phenotypic expression. As genetic tests are routinely used for diagnostic confirmation of HSAN III only, other means of differentiating between the disorders is necessary. Diagnosis is based on the clinical features, the degree of both sensory and autonomic dysfunction, and biochemical evaluations, with pathologic examinations serving to further confirm differences. Treatments for all these disorders are supportive.

  17. Hereditary sensory and autonomic neuropathies: types II, III, and IV

    Axelrod Felicia B

    2007-10-01

    Full Text Available Abstract The hereditary sensory and autonomic neuropathies (HSAN encompass a number of inherited disorders that are associated with sensory dysfunction (depressed reflexes, altered pain and temperature perception and varying degrees of autonomic dysfunction (gastroesophageal reflux, postural hypotention, excessive sweating. Subsequent to the numerical classification of four distinct forms of HSAN that was proposed by Dyck and Ohta, additional entities continue to be described, so that identification and classification are ongoing. As a group, the HSAN are rare diseases that affect both sexes. HSAN III is almost exclusive to individuals of Eastern European Jewish extraction, with incidence of 1 per 3600 live births. Several hundred cases with HSAN IV have been reported. The worldwide prevalence of HSAN type II is very low. This review focuses on the description of three of the disorders, HSAN II through IV, that are characterized by autosomal recessive inheritance and onset at birth. These three forms of HSAN have been the most intensively studied, especially familial dysautonomia (Riley-Day syndrome or HSAN III, which is often used as a prototype for comparison to the other HSAN. Each HSAN disorder is likely caused by different genetic errors that affect specific aspects of small fiber neurodevelopment, which result in variable phenotypic expression. As genetic tests are routinely used for diagnostic confirmation of HSAN III only, other means of differentiating between the disorders is necessary. Diagnosis is based on the clinical features, the degree of both sensory and autonomic dysfunction, and biochemical evaluations, with pathologic examinations serving to further confirm differences. Treatments for all these disorders are supportive.

  18. 40 CFR Appendix IV to Part 600 - Sample Fuel Economy Labels for 2008 and Later Model Year Vehicles

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Sample Fuel Economy Labels for 2008 and Later Model Year Vehicles IV Appendix IV to Part 600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Pt. 600, App. IV Appendix IV to Part...

  19. Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides from β-Lactoglobulin Secreted by Lactococcus lactis

    Suguru Shigemori

    2014-01-01

    Full Text Available Previous studies showed that hydrolysates of β-lactoglobulin (BLG prepared using gastrointestinal proteases strongly inhibit dipeptidyl peptidase-IV (DPP-IV activity in vitro. In this study, we developed a BLG-secreting Lactococcus lactis strain as a delivery vehicle and in situ expression system. Interestingly, trypsin-digested recombinant BLG from L. lactis inhibited DPP-IV activity, suggesting that BLG-secreting L. lactis may be useful in the treatment of type 2 diabetes mellitus.

  20. A Stable Coordination Complex of Rh(IV) in an N,O-Donor Environment.

    Sinha, Shashi B; Shopov, Dimitar Y; Sharninghausen, Liam S; Vinyard, David J; Mercado, Brandon Q; Brudvig, Gary W; Crabtree, Robert H

    2015-12-23

    We describe facial and meridional isomers of [Rh(III)(pyalk)3], as well as meridional [Rh(IV)(pyalk)3](+) {pyalk =2-(2-pyridyl)-2-propanoate}, the first coordination complex in an N,O-donor environment to show a clean, reversible Rh(III/IV) redox couple and to have a stable Rh(IV) form, which we characterize by EPR and UV-visible spectroscopy as well as X-ray crystallography. The unprecedented stability of the Rh(IV) species is ascribed to the exceptional donor strength of the ligands, their oxidation resistance, and the meridional coordination geometry.

  1. Synthesis and structure-activity relationships of potent 4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors.

    Fukushima, Hiroshi; Hiratate, Akira; Takahashi, Masato; Mikami, Ayako; Saito-Hori, Masako; Munetomo, Eiji; Kitano, Kiyokazu; Chonan, Sumi; Saito, Hidetaka; Suzuki, Akio; Takaoka, Yuji; Yamamoto, Koji

    2008-04-01

    Dipeptidyl peptidase IV (DPP-IV) inhibitors are promising antidiabetic drugs, and several drugs are in the developmental stage. We previously reported that the introduction of fluorine to the 4-position of 2-cyanopyrrolidine enhanced the DPP-IV inhibitory effect. In the present report, we examined the structure-activity relationship (SAR) of 2-cyano-4-fluoropyrrolidine with N-substituted glycine at the 1-position. We report the identification of a potent and stable DPP-IV inhibitor (TS-021) with a long-term persistent plasma drug concentration and a potent antihyperglycemic activity.

  2. Safety assessment of Tin(IV) oxide as used in cosmetics.

    Johnson, Wilbur; Bergfeld, Wilma F; Belsito, Donald V; Hill, Ronald A; Klaassen, Curtis D; Liebler, Daniel C; Marks, James G; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Andersen, F Alan

    2014-01-01

    Tin(IV) oxide functions as an abrasive, bulking, and opacifying agent in cosmetic products and is used at concentrations up to 0.4% in rinse-off products and up to 1.3% in leave-on products. The Cosmetic Ingredient Review Expert Panel (Panel) noted that tin(IV) oxide is a water-insoluble inorganic metal compound and should not be percutaneously absorbed; therefore, systemic exposure is not likely. Studies of dermal application of tin(IV) oxide were considered to determine toxicity at the site of application. The Panel concluded that tin(IV) oxide is safe in the present practices of use and concentration.

  3. Pembrolizumab and Ruxolitinib Phosphate in Treating Patients With Metastatic Stage IV Triple Negative Breast Cancer

    2017-03-15

    Breast Carcinoma Metastatic in the Bone; Estrogen Receptor Negative; HER2/Neu Negative; Progesterone Receptor Negative; Recurrent Breast Carcinoma; Stage IV Breast Cancer; Triple-Negative Breast Carcinoma

  4. Promoting safe IV management in practice using H.A.N.D.S.

    Frimpong, Angela; Caguioa, Jennifer; Octavo, Genevi

    The aim of this article is to promote best practice for the insertion and care of intravascular (IV) devices. The H.A.N.D.S. acronym was created to serve as an aide memoire to general and specialist nurses regarding the 5 key interventions to prevent catheter-related bloodstream infections (CRBSIs). In order to promote safe and evidence-based practice in IV therapy a practical guide with clinical information about common IV procedures has been developed. This article provides back-to-basics guidance on how to deliver IV therapy safely and effectively.

  5. Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma

    2016-05-06

    Acral Lentiginous Malignant Melanoma; Lentigo Maligna Malignant Melanoma; Nodular Malignant Melanoma; Recurrent Melanoma; Solar Radiation-related Skin Melanoma; Stage IV Melanoma; Superficial Spreading Malignant Melanoma

  6. Speciation of technetium(IV) in bicarbonate media.

    Alliot, Isabelle; Alliot, Cyrille; Vitorge, Pierre; Fattahi, Massoud

    2009-12-15

    The technetium isotope (99)Tc is a major fission product from nuclear reactors. Ultimately it is disposed of as radioactive waste since it has few applications outside of scientific research. Geochemical modeling of the dissolution of nuclear waste and of the solubility and speciation of the dissolved radionuclides in groundwater is an important part of the Performance Assessment for the safety of nuclear waste repositories. It relies on the availability of a critically assessed thermodynamic database. The potential of the Tc(VII)/Tc(IV) redox couple is measured here under various chemical conditions to verify the stoichiometries of Tc complexes and determine their stabilities: (i) -log(10)[H(+)] in the range 7.0-10.0, for 0.3, 0.6, and 0.7 M [CO(3)](total); (ii) [CO(3)](total) in the range 0.01-0.6 M at -log(10)[H(+)] approximately 8.6; and (iii) [Tc(VII)]/[Tc(IV] ratios of (6.02 10(-5) M)/(10(-6) M) and (6.02 10(-5) M)/(6.02 10(-5) M) at -log(10)[H(+)] = -9.1 and [CO(3)](total) = 1 M. Assuming that Tc(VII), TcO(4)(-) is the only species which exists under all the above chemical conditions, the potentiometric results can be interpreted by considering the presence of two hydroxide-carbonate monomeric complexes. The hydrolysis equilibrium between these two complexes is Tc(CO(3))(OH)(2) + H(2)O Tc(CO(3))(OH)(3)(-) + H(+) with -log(10)[H(+)](1/2) = 8.69 +/- 0.20, which is consistent with the -8.3 +/- 0.6 corresponding hydrolysis constant of the NEA TDB review. 733 +/- 44 mV/SHE and 575 +/- 60 mV/SHE are measured for the standard potentials of the TcO(4)(-)/Tc(CO(3))(OH)(2), and for the TcO(4)(-)/Tc(CO(3))(OH)(3)(-) redox couples respectively. The corresponding formation constants from TcO(OH)(2) are log(10)K(1,2) = 19.8 +/- 0.5 and log(10)K(1,3) = 10.5 +/- 0.5, to be compared with the 19.3 +/- 0.3 and 11.0 +/- 0.6 values proposed by the NEA TDB review. Note that these values have been converted for the formation reactions described here, thus the given values are not

  7. Prenatal IV Cocaine: Alterations in Auditory Information Processing

    Charles F. Mactutus

    2011-06-01

    Full Text Available One clue regarding the basis of cocaine-induced deficits in attentional processing is provided by the clinical findings of changes in the infants’ startle response; observations buttressed by neurophysiological evidence of alterations in brainstem transmission time. Using the IV route of administration and doses that mimic the peak arterial levels of cocaine use in humans, the present study examined the effects of prenatal cocaine on auditory information processing via tests of the acoustic startle response (ASR, habituation, and prepulse inhibition (PPI in the offspring. Nulliparous Long-Evans female rats, implanted with an IV access port prior to breeding, were administered saline, 0.5, 1.0, or 3.0 mg/kg/injection of cocaine HCL (COC from gestation day (GD8-20 (1x/day-GD8-14, 2x/day-GD15-20. COC had no significant effects on maternal/litter parameters or growth of the offspring. At 18-20 days of age, one male and one female, randomly selected from each litter displayed an increased ASR (>30% for males at 1.0 mg/kg and >30% for females at 3.0 mg/kg. When reassessed in adulthood (D90-100, a linear dose-response increase was noted on response amplitude. At both test ages, within-session habituation was retarded by prenatal cocaine treatment. Testing the females in diestrus vs. estrus did not alter the results. Prenatal cocaine altered the PPI response function across interstimulus interval (ISI and induced significant sex-dependent changes in response latency. Idazoxan, an alpha2-adrenergic receptor antagonist, significantly enhanced the ASR, but less enhancement was noted with increasing doses of prenatal cocaine. Thus, in utero exposure to cocaine, when delivered via a protocol designed to capture prominent features of recreational usage, causes persistent, if not permanent, alterations in auditory information processing, and suggests dysfunction of the central noradrenergic circuitry modulating, if not mediating, these responses.

  8. Humboldt, un prusiano en la Corte del Rey Carlos IV

    Puig-Samper, Miguel Ángel

    1999-08-01

    Full Text Available The study of Alejandro de Humboldt's transit through Spain and particularly Madrid, has been one of the forgotten aspects of his historiography. The reasons that would explain the approval by king Charles IV of his trip, involving the minister Mariano de Urquijo and the embassador of Sajonia, baron of Forell, are not sufficiently documented due to the scarce data that Humboldt himself offered in his work and to the absence of any other supporting documents. This work studies the preparation of his American trip and its approval by the Spanish court. It incorporates the Memorandum presented —which was «lost» until now—, the autobiography submitted to the authorities and the references given by Philippe de Forrell. Furthermore, it analyses his relationships with the Spanish scientific community in Madrid and the profile of the team that supported him to achieve his targets.

    El estudio del paso de Alejandro de Humboldt por España y especialmente por Madrid ha sido tradicionalmente uno de los aspectos más olvidados en la historiografía humboldtiana. La repetición de los pocos datos que él mismo ofreció en su obra y la falta de documentos ha hecho insuficiente la explicación de cómo fue aprobado su viaje por el rey Carlos IV, con la intervención del ministro Mariano Luis de Urquijo y del embajador de Sajonia, barón de Forell. En el presente trabajo se estudia la preparación de su viaje americano y su aprobación en la Corte española, aportando la Memoria presentada —abasta ahora «perdida»—, la autobiografía que elevó a las autoridades y el aval de Philippe de Forell. Asimismo se analizan sus relaciones con los científicos españoles en Madrid y el perfil del grupo que le ayudó a conseguir sus objetivos.

  9. Restauration de la statue de Henri IV

    Stéphanie Celle

    2012-04-01

    Full Text Available Cette intervention de conservation du bronze de la statue de Henri IV était la première depuis sa création en 1818 : on héritait de la surface originale de l’œuvre altérée par les vicissitudes du temps et les événements historiques traversés. Le protocole de conservation se voulait respectueux de cette authenticité de la patine et a cherché à en laisser les marques tout en apportant une réponse pour contrer la corrosion active de l’alliage. C’est en conformité aux principes de conservation établis par Cesare Brandi, qu’ont été définis le nettoyage sélectif des surfaces et l’application de couches protectives sur le bronze. Par ailleurs, le moment du chantier est un moment privilégié pour observer un monument et mieux connaître son histoire particulière. Ce chantier nous a permis de redécouvrir deux ensembles de boîtes déposées dans l’antre du cheval dans des situations parfois surprenantes.This conservation treatment for the bronze statue of Henri IV is the first since its creation in 1818. While the original surface of the work remains, it has been altered by natural and human forces; including the weathering of the material from exposure to the elements and damage caused by historic events. The conservation protocol is respectful of this authenticity of the surface patina and the marks of damage due to historical events, while developing a treatment plan to counter the active corrosion of the alloy. In keeping with the principles of conservation established by Cesare Brandi, the treatment program defines the selective cleaning of the surface and the application of several layers of a protective coating on the bronze. In addition, the conservation project is an opportunity to carefully study a monument to better understand its unique history. This project allowed us to rediscover two sets of boxes placed inside the cavity of the horse; an unxpected discovery.

  10. The Dependence of C IV Broad Absorption Line Properties on Accompanying Si IV and Al III Absorption: Relating Quasar-Wind Ionization Levels, Kinematics, and Column Densities

    Ak, N Filiz; Hall, P B; Schneider, D P; Trump, J R; Anderson, S F; Hamann, F; Myers, Adam D; Paris, I; Petitjean, P; Ross, Nicholas P; Shen, Yue; York, Don

    2014-01-01

    We consider how the profile and multi-year variability properties of a large sample of C IV Broad Absorption Line (BAL) troughs change when BALs from Si IV and/or Al III are present at corresponding velocities, indicating that the line-of-sight intercepts at least some lower ionization gas. We derive a number of observational results for C IV BALs separated according to the presence or absence of accompanying lower ionization transitions, including measurements of composite profile shapes, equivalent width (EW), characteristic velocities, composite variation profiles, and EW variability. We also measure the correlations between EW and fractional-EW variability for C IV, Si IV, and Al III. Our measurements reveal the basic correlated changes between ionization level, kinematics, and column density expected in accretion-disk wind models; e.g., lines-of-sight including lower ionization material generally show deeper and broader C IV troughs that have smaller minimum velocities and that are less variable. Many C ...

  11. Transformation of Tri-Titanium(IV-Substituted α-Keggin Polyoxometalate (POM into Tetra-Titanium(IV-Substituted POMs : Reaction Products of Titanium(IV Sulfate with the Dimeric Keggin POM Precursor under Acidic Conditions

    Kenji Nomiya

    2010-01-01

    Full Text Available Reaction products of titanium(IV sulfate in HCl-acidic aqueous solution with the dimeric species linked through three intermolecular Ti-O-Ti bonds of the two tri-titanium(IV-substituted α-Keggin polyoxometalate (POM subunits are described. Two novel titanium(IV-containing α-Keggin POMs were obtained under different conditions. One product was a dimeric species through two intermolecular Ti-O-Ti bonds of the two tetra-titanium(IV-substituted α-Keggin POM subunits, i.e., [[{Ti(H2O3}2(μ-O](α-PW9Ti2O38]26- (1. The other product was a monomeric α-Keggin species containing the tetra-titanium(IV oxide cluster and two coordinated sulfate ions, i.e., [{Ti4(μ-O3(SO42(H2O8}(α-PW9O34]3- (2. Molecular structures of 1 and 2 were also discussed based on host (lacunary site-guest (titanium atom chemistry.

  12. Type-IV Pilus Deformation Can Explain Retraction Behavior

    Ghosh, Ranajay; Vaziri, Ashkan

    2014-01-01

    Polymeric filament like type IV Pilus (TFP) can transfer forces in excess of 100pN during their retraction before stalling, powering surface translocation(twitching). Single TFP level experiments have shown remarkable nonlinearity in the retraction behavior influenced by the external load as well as levels of PilT molecular motor protein. This includes reversal of motion near stall forces when the concentration of the PilT protein is lowered significantly. In order to explain this behavior, we analyze the coupling of TFP elasticity and interfacial behavior with PilT kinetics. We model retraction as reaction controlled and elongation as transport controlled process. The reaction rates vary with TFP deformation which is modeled as a compound elastic body consisting of multiple helical strands under axial load. Elongation is controlled by monomer transport which suffer entrapment due to excess PilT in the cell periplasm. Our analysis shows excellent agreement with a host of experimental observations and we prese...

  13. SDSS-IV MaNGA: Project Overview

    Bundy, Kevin; MaNGA Team

    2016-01-01

    I present an overview of the scientific motivation and basic design of the Sloan Digital Sky Survey-IV program, MaNGA: Mapping Nearby Galaxies at Apache Point Observatory. MaNGA is currently in its second year of operations with roughly 2000 galaxies now observed, already the largest integral field spectroscopic survey of galaxies ever conducted. By combining the wealth of information made available by resolved spectroscopy with the statistical power of a sample of 10,000 galaxies, MaNGA is providing transformative insights on key questions about the life history of galaxies. These questions range from the nature of growth of star-forming disks and stellar spheroidals, to the physical origin of star formation quenching, to the ways in which the different mass components in galaxies interact and assemble over time. MaNGA's success owes to a dedicated team of scientists, engineers, and observers working to optimize the survey operations and develop advanced data processing, analysis, and interface tools in order to fully realize MaNGA's exciting potential. Continuing in the Sloan tradition, MaNGA data products will be made publicly available, with the first release scheduled for Summer 2016.

  14. The [Fe IV] Discrepancy: Constraining the Iron Abundances in Nebulae

    Rodríguez, M; Einert, Thomas; Lipowsky, Peter; Schilling, Jorg; Bowick, Mark; Bausch, Andreas; Rodriguez, Monica; Rubin, Robert H.

    2005-01-01

    We study the current discrepancy between the model-predicted and measured concentrations of Fe++ and Fe3+ in ionized nebulae. We calculate a set of photoionization models, updated with the atomic data relevant to the problem, and compare their results with those derived for the available nebulae where both [Fe III] and [Fe IV] lines have been measured. Our new model results are closer to the measured values than the results of previous calculations, but a discrepancy remains. This discrepancy translates into an uncertainty in the derived Fe abundances of a factor up to ~4. We explore the possible causes of this discrepancy and find that errors in the Fe atomic data may be the most likely explanation. The discrepancy can be fully accounted for by any of the following changes: (1) an increase by a factor of ~10 in the recombination rate (radiative plus dielectronic, or charge transfer) for Fe3+, (2) an increase by a factor of 2-3 in the effective collision strengths for Fe++, or (3) a decrease by a factor of 2-...

  15. Prediction of survival in patients with Stage IV kidney cancer

    L. V. Mirilenko

    2015-01-01

    Full Text Available The efficiency of treatment was evaluated and the predictors of adjusted survival (AS were identified in patients with disseminated kidney cancer treated at the Republican Research and Practical Center for Oncology and Medical Radiology in 1999 to 2011 (A.E. Okeanov, P.I. Moiseev, L.F. Levin. Malignant tumors in Belarus, 2001–2012. Edited by O.G. Sukonko. Seven factors (regional lymph node metastases; distant bone metastases; a high-grade tumor; sarcomatous tumor differentiation; hemoglobin levels of < 125 g/l in women and < 150 g/l in men; an erythrocyte sedimentation rate of 40 mm/h; palliative surgery were found to have an independent, unfavorable impact on AS. A multidimensional model was built to define what risk group low (no more than 2 poor factors, moderate (3–4 poor factors, and high (more than 4 poor factors the patients with Stage IV kidney cancer belonged to. In these groups, the median survival was 34.7, 17.2, and 4.0 months and 3-year AS rates were 48.6, 24.6, and 3.2 %, respectively. 

  16. Two-dimensional multiferroics in monolayer group IV monochalcogenides

    Wang, Hua; Qian, Xiaofeng

    2017-03-01

    Low-dimensional multiferroic materials hold great promises in miniaturized device applications such as nanoscale transducers, actuators, sensors, photovoltaics, and nonvolatile memories. Here, using first-principles theory we predict that two-dimensional (2D) monolayer group IV monochalcogenides including GeS, GeSe, SnS, and SnSe are a class of 2D semiconducting multiferroics with giant strongly-coupled in-plane spontaneous ferroelectric polarization and spontaneous ferroelastic lattice strain that are thermodynamically stable at room temperature and beyond, and can be effectively modulated by elastic strain engineering. Their optical absorption spectra exhibit strong in-plane anisotropy with visible-spectrum excitonic gaps and sizable exciton binding energies, rendering the unique characteristics of low-dimensional semiconductors. More importantly, the predicted low domain wall energy and small migration barrier together with the coupled multiferroic order and anisotropic electronic structures suggest their great potentials for tunable multiferroic functional devices by manipulating external electrical, mechanical, and optical field to control the internal responses, and enable the development of four device concepts including 2D ferroelectric memory, 2D ferroelastic memory, and 2D ferroelastoelectric nonvolatile photonic memory as well as 2D ferroelectric excitonic photovoltaics.

  17. Infantile tibia vara: Treatment of Langenskiold stage IV

    Umrani Salil

    2008-01-01

    Full Text Available An eight year old girl presented with a progressively increasing deformity of the left proximal tibia since last 2 years. She had no history of trauma, fever and swelling of left knee. There were no obvious signs of rickets/muscular dystrophy. She had 25 degrees of tibia vara clinically with lateral thrust and a prominent fibular head. The radiograph of left knee revealed tibia vara with medial beaking and a significant depression of the medial tibial epiphysis and metaphysis. A computed tomography (CTscan revealed significant depression of the medial tibial epiphysis but no bony bar in the physis or fusion of the medical tibial epiphysis. There was a posterior slope in addition to the medial one. She was treated with elevation of the medial tibial hemiplateau with subtuberosity valgus derotation dome osteotomy. She also underwent a lateral proximal tibial hemiphysiodesis (temporary stapling. A prophylactic subcutaneons anterolateral compartment fasciotomy was also performed. All osteotomies united in 2 months. All deformities were corrected and she regained a knee range of 0 to 130 degrees. At final followup (4 years, there was no recurrence of varus deformity, knee was stable, with 1cm of leg length discrepancy. In Langenskiold stage IV tibia vara, elevation of medial tibial plateau, a subtuberosity valgus derotation osteotomy and a concomitant lateral hemiephiphysiodesis has given good results.

  18. The nature of paramagnetic defects in tin (IV) oxide

    Ivanovskaya, M., E-mail: ivanovskaya@bsu.by [Research Institute for Physical Chemical Problems, Belarusian State University, Leningradskaya Str., 14, 220030 Minsk (Belarus); Ovodok, E., E-mail: ovodokea@gmail.com [Research Institute for Physical Chemical Problems, Belarusian State University, Leningradskaya Str., 14, 220030 Minsk (Belarus); Golovanov, V. [South-Ukrainian University, Staroportofrankovskaya Str., 26, 65008 Odessa (Ukraine)

    2015-08-18

    Highlights: • EPR signal at g = 1.8–1.9 (D) was studied in SnO{sub 2} prepared under different conditions. • Conditions appropriate for detection of D signal and parameters of them were defined. • Structure of paramagnetic center (PC) attributed to the D signal was proposed. • The PC is a complex of oxygen vacancies with entrapped electrons near SnO{sub 2} surface. - Abstract: The nature of paramagnetic centers which are responsible for the EPR signal at g = 1.8–1.9 in tin (IV) oxide was studied. Polycrystalline SnO{sub 2} samples were obtained by sol–gel method and by thermal treatment of the precursors containing tin atoms in different oxidation states. The parameters of the EPR spectra recorded after heat treatment of the samples in air, oxygen and hydrogen atmospheres, and in vacuum were analyzed. The observed parameters of the EPR spectra do not allow to assign the paramagnetic center with g = 1.8–1.9 to Sn{sup 3+} center. The structure of the paramagnetic center attributed to the EPR signal at g = 1.8–1.9 was proposed. The proposed structure of the paramagnetic center includes a complex of oxygen vacancies at (1 0 1) plane of rutile-type SnO{sub 2} lattice.

  19. An Economic Analysis of Generation IV Small Modular Reactors

    Stewart, J S; Lamont, A D; Rothwell, G S; Smith, C F; Greenspan, E; Brown, N; Barak, A

    2002-03-01

    This report examines some conditions necessary for Generation IV Small Modular Reactors (SMRs) to be competitive in the world energy market. The key areas that make nuclear reactors an attractive choice for investors are reviewed, and a cost model based on the ideal conditions is developed. Recommendations are then made based on the output of the cost model and on conditions and tactics that have proven successful in other industries. The Encapsulated Nuclear Heat Source (ENHS), a specific SMR design concept, is used to develop the cost model and complete the analysis because information about the ENHS design is readily available from the University of California at Berkeley Nuclear Engineering Department. However, the cost model can be used to analyze any of the current SMR designs being considered. On the basis of our analysis, we determined that the nuclear power industry can benefit from and SMRs can become competitive in the world energy market if a combination of standardization and simplification of orders, configuration, and production are implemented. This would require wholesale changes in the way SMRs are produced, manufactured and regulated, but nothing that other industries have not implemented and proven successful.

  20. Nonlinear I-V characteristics of nanoparticle compacts and nanocomposites

    Herth, Simone [Rensselaer Polytechnic Institute, Troy, NY (United States); Bielefeld University, Bielefeld (Germany); Wang, Xiaoping; Hugener, Teresa; Schadler, Linda; Siegel, Richard [Rensselaer Polytechnic Institute, Troy, NY (United States); Hillborg, Henrik; Auletta, Tommaso [ABB AB, Corporate Research, Schweden (Sweden)

    2007-07-01

    Materials with nonlinear I-V characteristics are commonly used as field grading materials. In many cases, the non-linearity is achieved through the addition of equiaxed fillers to a polymer matrix. These composite field grading materials are optimized in terms of nonlinearity, conductivity, and breakdown strength. One limitation in designing new field grading materials is a robust understanding of the relationship between powder morphology, composition and electrical characteristics of the powder, as well as a robust understanding of the relationship between powder conductivity and non-linearity and composite non-linearity. In this work, treatment of ZnO powder with a SnF{sub 2} solution resulted in a powder that yielded highly non-linear behavior. The highest non-linearity was achieved for powders with at least two different phases and a rough surface, as indicated by transmission electron micrographs. In contrast, the non-linearity of the nanocomposite conductivity is mainly determined by the conductivity of the nanofiller. The electrical behavior of the non-linear powder can be understood by a polarization of the nanoparticles at the interfaces, whereas the nonlinearity of the nanocomposites can be explained by a tunnelling mechanism between two particles.

  1. II-IV-V Based Thin Film Tandem Photovoltaic Cell

    Newman, Nathan [Arizona State Univ., Mesa, AZ (United States); van Schilfgaarde, Mark [Arizona State Univ., Mesa, AZ (United States)

    2012-10-04

    [Through a combination of theory and experiment that, absent unknown mitigating factors, a tandem cell whose (wide-gap. 1.8 eV) top layer is made of ZnSnP2 and whose (narrow gap, 1.1 eV) bottom layer consisting of ZnGeAs2 are near-ideal materials for a tandem cell. Not only are there gaps optimally adjusted to the solar spectrum, but the two compounds are lattice-matched, and their energy band structure and optical absorption are also near-ideal (they closely resemble that of GaAs). Our first major challenge is to establish that high-quality II-IV-V thin films can be synthesized. We have begun growing and characterizing films of ZnGeAs2 and ZnSnP2, initially grown on Ge substrates (the lattice constant of Ge matches these compounds) by pulsed laser ablation and sputtering. In tandem are theoretical calculations to guide the experiments. The goal is to develop methods that can be used to produce a pair of lattice-matched thin films that will be useful in tandem cells.

  2. Molecular evolution of the cacophony IVS6 region in sandflies.

    Lins, R M M A; Oliveira, S G; Souza, N A; de Queiroz, R G; Justiniano, S C B; Ward, R D; Kyriacou, C P; Peixoto, A A

    2002-04-01

    A number of insects produce acoustic signals during courtship. Genes involved in the control of the courtship song are particularly interesting from an evolutionary viewpoint because interspecific variation in this signal is potentially important as a reproductive isolation mechanism and, as a consequence, in the speciation process. The cacophony gene was identified by a mutation affecting the "lovesong" in Drosophila melanogaster. Phlebotomine sandflies (Diptera: Psychodidae) also produce acoustic stimuli during courtship and therefore cacophony can be used as an interesting molecular marker in evolutionary studies in these important disease vectors. In this paper we have studied the molecular evolution of the IVS6 region of cacophony in sandflies. We compared the level of divergence in the exon sequences encoding this conserved domain in Drosophila and Phlebotomines. We also analysed the high level of variation in an intron that is present in sandflies but that was lost in Drosophila during evolution. The available cacophony sequences were also used for a phylogenetic analysis of some species of the Neotropical genus Lutzomyia.

  3. Mucolipidosis type IV and the mucolipins.

    Bach, Gideon; Zeevi, David A; Frumkin, Ayala; Kogot-Levin, Aviram

    2010-12-01

    MLIV (mucolipidosis type IV) is a neurodegenerative lysosomal storage disorder caused by mutations in MCOLN1, a gene that encodes TRPML1 (mucolipin-1), a member of the TRPML (transient receptor potential mucolipin) cation channels. Two additional homologues are TRPML2 and TRPML3 comprising the TRPML subgroup in the TRP superfamily. The three proteins play apparently key roles along the endocytosis process, and thus their cellular localization varies among the different group members. Thus TRPML1 is localized exclusively to late endosomes and lysosomes, TRPML2 is primarily located in the recycling clathrin-independent GPI (glycosylphosphatidylinositol)-anchored proteins and early endosomes, and TRPML3 is primarily located in early endosomes. Apparently, all three proteins' main physiological function underlies Ca(2+) channelling, regulating the endocytosis process. Recent findings also indicate that the three TRPML proteins form heteromeric complexes at least in some of their cellular content. The physiological role of these complexes in lysosomal function remains to be elucidated, as well as their effect on the pathophysiology of MLIV. Another open question is whether any one of the TRPMLs bears additional function in channel activity.

  4. Density functional theory study of phase IV of solid hydrogen

    Pickard, Chris J.; Martinez-Canales, Miguel; Needs, Richard J.

    2012-06-01

    We have studied solid hydrogen up to pressures of 300 GPa and temperatures of 350 K using density functional theory methods and have found “mixed structures” that are more stable than those predicted earlier. Mixed structures consist of alternate layers of strongly bonded molecules and weakly bonded graphene-like sheets. Quasiharmonic vibrational calculations show that mixed structures are the most stable at room temperature over the pressure range 250-295 GPa. These structures are stabilized with respect to strongly bonded molecular phases at room temperature by the presence of lower frequency vibrational modes arising from the graphene-like sheets. Our results for the mixed structures are consistent with the experimental Raman data [M. I. Eremets and I. A. Troyan, Nat. Mater.1476-112210.1038/nmat3175 10, 927 (2011) and R. T. Howie , Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.108.125501 108, 125501 (2012)]. We find that mixed phases are reasonable structural models for phase IV of hydrogen.

  5. Molecular and immunological characterization of DNA ligase IV deficiency.

    Jiang, Jinqiu; Tang, Wenjing; An, Yunfei; Tang, Maozhi; Wu, Junfeng; Qin, Tao; Zhao, Xiaodong

    2016-02-01

    DNA ligase IV (LIG4) deficiency is an extremely rare autosomal recessive primary immunodeficiency disease caused by the LIG4 mutation. To date, fewer than 30 cases of patients have been reported worldwide. No reversion mutations have been previously identified in LIG4. This study enrolled seven Chinese patients with LIG4 deficiency who presented with combined immunodeficiency, microcephaly, and growth retardation. One patient (P1) acquired non-Hodgkin lymphoma. Four patients had impaired T cell proliferation function and skewed T cell receptor diversity. Five novel mutations in LIG4 and a potential hotspot mutation (c.833G>T; p.R278L) in the Chinese population were identified. TA cloning analysis of T cells, NK cells, granulocytes, and oral mucosa cells in P6 revealed wild-type clones and clones that contained both maternally and paternally inherited mutations, indicating possible somatic reversion which need further investigation since no functional or protein assays were possible for all the patients died and no cell lines were available.

  6. Modelling of advanced structural materials for GEN IV reactors

    Samaras, M.; Hoffelner, W.; Victoria, M.

    2007-09-01

    The choice of suitable materials and the assessment of long-term materials damage are key issues that need to be addressed for the safe and reliable performance of nuclear power plants. Operating conditions such as high temperatures, irradiation and a corrosive environment degrade materials properties, posing the risk of very expensive or even catastrophic plant damage. Materials scientists are faced with the scientific challenge to determine the long-term damage evolution of materials under service exposure in advanced plants. A higher confidence in life-time assessments of these materials requires an understanding of the related physical phenomena on a range of scales from the microscopic level of single defect damage effects all the way up to macroscopic effects. To overcome lengthy and expensive trial-and-error experiments, the multiscale modelling of materials behaviour is a promising tool, bringing new insights into the fundamental understanding of basic mechanisms. This paper presents the multiscale modelling methodology which is taking root internationally to address the issues of advanced structural materials for Gen IV reactors.

  7. OGLE-IV Real-Time Transient Search

    Wyrzykowski, L; Kozlowski, S; Udalski, A; Poleski, R; Skowron, J; Blagorodnova, N; Kubiak, M; Szymanski, M K; Pietrzynski, G; Soszynski, I; Ulaczyk, K; Pietrukowicz, P; Mroz, P

    2014-01-01

    We present the design and first results of a real-time search for transients within the 650 sq. deg. area around the Magellanic Clouds, conducted as part of the OGLE-IV project and aimed at detecting supernovae, novae and other events. The average sampling of about 4 days from September to May, yielded a detection of 238 transients in 2012/2013 and 2013/2014 seasons. The superb photometric and astrometric quality of the OGLE data allows for numerous applications of the discovered transients. We use this sample to prepare and train a Machine Learning-based automated classifier for early light curves, which distinguishes major classes of transients with more than 80% of correct answers. Spectroscopically classified 49 supernovae Type Ia are used to construct a Hubble Diagram with statistical scatter of about 0.3 mag and fill the least populated region of the redshifts range in the Union sample. We investigate the influence of host galaxy environments on supernovae statistics and find the mean host extinction of...

  8. Role of Mitochondrial Complex IV in Age-Dependent Obesity

    Ines Soro-Arnaiz

    2016-09-01

    Full Text Available Aging is associated with progressive white adipose tissue (WAT enlargement initiated early in life, but the molecular mechanisms involved remain unknown. Here we show that mitochondrial complex IV (CIV activity and assembly are already repressed in white adipocytes of middle-aged mice and involve a HIF1A-dependent decline of essential CIV components such as COX5B. At the molecular level, HIF1A binds to the Cox5b proximal promoter and represses its expression. Silencing of Cox5b decreased fatty acid oxidation and promoted intracellular lipid accumulation. Moreover, local in vivo Cox5b silencing in WAT of young mice increased the size of adipocytes, whereas restoration of COX5B expression in aging mice counteracted adipocyte enlargement. An age-dependent reduction in COX5B gene expression was also found in human visceral adipose tissue. Collectively, our findings establish a pivotal role for CIV dysfunction in progressive white adipocyte enlargement during aging, which can be restored to alleviate age-dependent WAT expansion.

  9. Group IV photonic devices for the mid-infrared

    Mashanovich, G. Z.; Nedeljkovic, M.; Milosevic, M. M.; Hu, Y.; Gardes, F. Y.; Thomson, D. J.; Masaud, T.-B.; Jaberansary, E.; Chong, H. M. H.; Soref, R.; Reed, G. T.

    2012-06-01

    Group IV mid-infrared photonics is attracting more research interest lately. The main reason is a host of potential applications ranging from sensing, to medicine, to free space communications and infrared countermeasures. The field is, however, in its infancy and there are several serious challenges to be overcome before we see progress similar to that in the near-infrared silicon photonics. The first is to find suitable material platforms for the mid-infrared. In this paper we present experimental results for passive mid-infrared photonic devices realised in silicon-on-insulator, silicon-on-sapphire, and silicon on porous silicon. We also present relationships for the free-carrier induced electro-refraction and electro-absorption in silicon and germanium in the mid-infrared wavelength range. Electro-absorption modulation is calculated from impurity-doping spectra taken from the literature, and a Kramers-Kronig analysis of these spectra is used to predict electro-refraction modulation. We examine the wavelength dependence of electro-refraction and electro-absorption, finding that the predictions suggest longer-wave modulator designs will in many cases be different than those used in the telecom range.

  10. Activities and Products at IVS combination center at BKG

    Bachmann, S.; Lösler, M.

    2013-08-01

    The IVS combination center is primarily responsible to provide rapid EOP products based on observation campaigns twice a week and a long-term EOP series which is updated four times a year. Besides EOP products, methods and analysis of combined station coordinates and source positions are evolving and new products are developed in order to expand the range of combined VLBI products. Within the last year the combination center continuously worked on several improvements and refinements of the combination procedure: outlier test have been improved, the detection of unsuitable sessions in order to improve the stability of the results, the modeling of station coordinates of the reference frame generation and the data presentation on the combination centers website. Besides the routine combination of 24h VLBI sessions, several other projects have been developed, e.g. the preparation of the latest VLBI reference frame (VTRF) including the calculation of station height variations and baseline lengths generation derived by the combination of station coordinates. The combination center is furthermore intensely working on the combination of source coordinates and on providing user friendly online analysis tools on the combination centers website in order to meet the user requirements.

  11. Validation of DSM-IV Model of Psychiatric Syndromes in Children with Autism Spectrum Disorders

    Lecavalier, Luc; Gadow, Kenneth D.; DeVincent, Carla J.; Edwards, Michael C.

    2009-01-01

    The objective of this study was to assess the internal construct validity of the DSM-IV as a conceptual model for characterizing behavioral syndromes in children with ASD. Parent and teachers completed the Child Symptom Inventory-4, a DSM-IV-referenced rating scale, for 6-to-12 year old clinic referrals with an ASD (N = 498). Ratings were…

  12. Rapid, Enhanced IV Characterization of Multi-Junction PV Devices under One Sun at NREL: Preprint

    Moriarty, Tom; France, Ryan; Steiner, Myles

    2015-09-15

    Multi-junction technology is rapidly advancing, which puts increasing demands on IV characterization resources. We report on a tool and procedure for fast turn-around of IV data under the reference conditions, but also under controlled variations from the reference conditions. This enhanced data set can improve further iterations of device optimization.

  13. 40 CFR Appendix IV to Part 92 - Guidelines for Determining Equivalency Between Emission Measurement Systems

    2010-07-01

    ... Between Emission Measurement Systems IV Appendix IV to Part 92 Protection of Environment ENVIRONMENTAL... Emission Measurement Systems This appendix describes a series of correlation criteria that EPA considers to... guidelines. When requested to make a finding of equivalency, EPA could base its decision on criteria...

  14. Analysis of WAIS-IV Index Score Scatter Using Significant Deviation from the Mean Index Score

    Gregoire, Jacques; Coalson, Diane L.; Zhu, Jianjun

    2011-01-01

    The Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) does not include verbal IQ and performance IQ scores, as provided in previous editions of the scale; rather, this edition provides comparisons among four index scores, allowing analysis of an individual's WAIS-IV performance in more discrete domains of cognitive ability. To supplement…

  15. WAIS-IV and Clinical Validation of the Four- and Five-Factor Interpretative Approaches

    Weiss, Lawrence G.; Keith, Timothy Z.; Zhu, Jianjun; Chen, Hsinyi

    2013-01-01

    The fourth edition of the Wechsler Adult Intelligence Scale (WAIS-IV) is a revised and substantially updated version of its predecessor. The purposes of this research were to determine the constructs measured by the test and the consistency of measurement across large normative and clinical samples. Competing higher order WAIS-IV four- and…

  16. Synthesis and Structural Characterization of a Molecular Plutonium(IV) Compound Constructed from Dimeric Building Blocks

    Runde, Wolfgang; Brodnax, Lia F.; Goff, George S.; Peper, Shane M.; Taw, Felicia L.; Scott, Brian L.

    2007-04-01

    Single crystals of Na8Pu2(O2)2(CO3)6•12H2O, exhibiting mu2, eta2-O2 ligands in unprecedented Pu(IV) dimeric units, were obtained at ambient temperature from aqueous Plutonium(IV) peroxide carbonate solution.

  17. Narrow C IV absorption doublets on quasar spectra of the Baryon Oscillation Spectroscopic Survey

    Chen, Zhi-Fu; Gu, Qiu-Sheng; Zhou, Luwenjia; Chen, Yan-Mei

    2016-11-01

    In this paper, we extend our work of Papers I and II, which are assigned to systematically survey C IV λλ1548,1551 narrow absorption lines (NALs) with zabs ≪ zem on quasar spectra of the Baryon Oscillation Spectroscopic Survey (BOSS) to collect C IV NALs with zabs ≈ zem from blue to red wings of C IV λ1549 emission lines. Together with Papers I and II, we have collected a total number of 41 479 C IV NALs with 1.4544 ≤ zabs ≤ 4.9224 in surveyed spectral region redward of Lyα until red wing of C IV λ1549 emission line. We find that the stronger C IV NALs tend to be the more saturated absorptions, and associated systems (zabs ≈ zem) seem to have larger absorption strengths when compared to intervening ones (zabs ≪ zem). The redshift density evolution behaviour of absorbers (the number of absorbers per redshift path) is similar to the history of the cosmic star formation. When compared to the quasar-frame velocity (β) distribution of Mg II absorbers, the β distribution of C IV absorbers is broader at β ≈ 0, shows longer extended tail, and exhibits a larger dispersion for environmental absorptions. In addition, for associated C IV absorbers, we find that low-luminosity quasars seem to exhibit smaller β and stronger absorptions when compared to high-luminosity quasars.

  18. Thermodynamics of Np(IV) complexes with gluconic acid under alkaline conditions. Sorption studies

    Rojo, H.; Garcia-Gutierrez, M.; Missana, T. [CIEMAT, Madrid (Spain). Sorption, Migration and Colloids Lab.; Tits, J.; Wieland, E. [Paul Scherrer Institut, Villigen (Switzerland). Lab. for Waste Management; Gaona, X. [Karlsruhe Institute of Technology, Karlsruhe (Germany). Inst. fuer Nukleare Entsorgung

    2013-05-01

    The complexation of Np(IV) with gluconic acid (GLU) under alkaline conditions was investigated in the absence of Ca by carrying out a series of sorption experiments. The decrease of Np(IV) sorption on the sorbing material at increasing concentrations of GLU was interpreted as the formation of Np(IV)-GLU aqueous complexes. The modelling of experimental data according to the Schubert method [1] confirmed the formation of a complex with a Np:GLU ratio 1: 1. The stoichiometry of the complex Np(OH){sub 4}GLU{sup -} was proposed based on the experimental observation that no proton exchange occurred during the course of the complexation reaction and that Np(OH){sub 4}(aq) was the predominant hydrolysis product in the absence of GLU. A log *{beta}{sup 0}{sub 1,4,1} = -2.92 {+-} 0.30 for the formation reaction Np{sup 4+} + 4H{sub 2}O + GLU{sup -} <=> Np(OH){sub 4}GLU{sup -} + 4H{sup +} was calculated based on the conditional stability constants determined from sorption experiments and using the Np(IV) thermodynamic data selected in the NEA reviews [2]. Linear free energy relationships (LFER) confirmed that the stoichiometry and stability of the Np(IV)-GLU complex characterized in this work are consistent with data available for Th(IV)-, U(IV)- and Pu(IV)-GLU complexes. (orig.)

  19. Uranium(IV) adsorption by natural organic matter in anoxic sediments

    Bone, Sharon E.; Dynes, James J.; Cliff, John; Bargar, John R.

    2017-01-09

    Uranium is an important carbon-free fuel source and environmental contaminant that accumulates in the tetravalent state, U(IV), in anoxic sediments, such as ore deposits, marine basins, and contaminated aquifers. However, little is known about the speciation of U(IV) in low-temperature geochemical environments, inhibiting the development of a conceptual model of U behavior. Until recently, U(IV) was assumed to exist predominantly as the sparingly soluble mineral uraninite (UO2+x) in anoxic sediments; however, studies now show that this is not often the case. Yet a model of U(IV) speciation in the absence of mineral formation under field-relevant conditions has not yet been developed. Uranium(IV) speciation controls its reactivity, particularly its susceptibility to oxidative mobilization, impacting its distribution and toxicity. Here we show adsorption to organic carbon and organic carbon-coated clays dominate U(IV) speciation in an organic-rich natural substrate under field-relevant conditions. Whereas previous research assumed that U(IV) speciation is dictated by the mode of reduction (i.e., whether reduction is mediated by microbes or by inorganic reductants), our results demonstrate that mineral formation can be diminished in favor of adsorption, regardless of reduction pathway. Projections of U transport and bioavailability, and thus its threat to human and ecosystem health, must consider U(IV) adsorption to organic matter within the sediment environment.

  20. Uranium(IV) adsorption by natural organic matter in anoxic sediments

    Bone, Sharon E.; Dynes, James J.; Cliff, John; Bargar, John R.

    2017-01-09

    Uranium is an important fuel source and a global environmental contaminant. It accumulates in the tetravalent state, U(IV), in anoxic sediments, including ore deposits, marine basins, and contaminated aquifers. However, very little is known about the speciation of U(IV) in low temperature geochemical environments, inhibiting the development of a conceptual model of U behavior. Until recently, U(IV) was assumed to exist predominantly as the sparingly soluble mineral uraninite (UO2) in anoxic sediments; yet studies now show that UO2 is not often dominant in these environments. However, a model of U(IV) speciation under environmentally relevant conditions has not yet been developed. Here we show that complexes of U(IV) adsorb on organic carbon and organic carbon-coated clays in an organic-rich natural substrate under field-relevant conditions. Whereas previous research assumed that the U(IV) product depended on the reduction pathway, our results demonstrate that UO2 formation can be inhibited simply by decreasing the U:solid ratio. Thus, it is the number and type of surface ligands that controls U(IV) speciation subsequent to U(VI) reduction. Projections of U transport and bioavailability, and thus its threat to human and ecosystem health, must consider retention of U(IV) ions within the local sediment environment.

  1. Control of human energy expenditure by cytochrome c oxidase subunit IV-2.

    Schiffer, Tomas A; Peleli, Maria; Sundqvist, Michaela L; Ekblom, Björn; Lundberg, Jon O; Weitzberg, Eddie; Larsen, Filip J

    2016-09-01

    Resting metabolic rate (RMR) in humans shows pronounced individual variations, but the underlying molecular mechanism remains elusive. Cytochrome c oxidase (COX) plays a key role in control of metabolic rate, and recent studies of the subunit 4 isoform 2 (COX IV-2) indicate involvement in the cellular response to hypoxia and oxidative stress. We evaluated whether the COX subunit IV isoform composition may explain the pronounced individual variations in resting metabolic rate (RMR). RMR was determined in healthy humans by indirect calorimetry and correlated to levels of COX IV-2 and COX IV-1 in vastus lateralis. Overexpression and knock down of the COX IV isoforms were performed in primary myotubes followed by evaluation of the cell respiration and production of reactive oxygen species. Here we show that COX IV-2 protein is constitutively expressed in human skeletal muscle and strongly correlated to RMR. Primary human myotubes overexpressing COX IV-2 displayed markedly (>60%) lower respiration, reduced (>50%) cellular H2O2 production, higher resistance toward both oxidative stress, and severe hypoxia compared with control cells. These results suggest an important role of isoform COX IV-2 in the control of energy expenditure, hypoxic tolerance, and mitochondrial ROS homeostasis in humans.

  2. The Bulimia Test--Revised: Validation with "DSM-IV" Criteria for Bulimia Nervosa.

    Thelen, Mark H.; And Others

    1996-01-01

    The Bulimia Test--Revised (BULIT-R) was given to 23 female subjects who met the criteria for bulimia in the "Diagnostic and Statistical Manual of Mental Disorders" (DSM-IV) and 124 female controls. The BULIT-R appears to be a valid instruction for identifying individuals who meet DSM-IV criteria for bulimia. (SLD)

  3. Reliability of DSM-IV Symptom Ratings of ADHD: Implications for DSM-V

    Solanto, Mary V.; Alvir, Jose

    2009-01-01

    Objective: The objective of this study was to examine the intrarater reliability of "DSM-IV" ADHD symptoms. Method: Two-hundred-two children referred for attention problems and 49 comparison children (all 7-12 years) were rated by parents and teachers on the identical "DSM-IV" items presented in two different formats, the…

  4. Type II and IV radio bursts in the active period October-November 2003

    Petoussis, V; Kontogeorgos, A; Moussas, X; Preka-Papadema, P; Hillaris, A; Caroubalos, C; Alissandrakis, C E; Bougeret, J -L; Dumas, G; 10.1063/1.2347978

    2010-01-01

    In this report we present the Type II and IV radio bursts observed and analyzed by the radio spectrograph ARTEMIS IV1, in the 650-20MHz frequency range, during the active period October-November 2003. These bursts exhibit very rich fine structures such fibers, pulsations and zebra patterns which is associated with certain characteristics of the associated solar flares and CMEs.

  5. Defining interactions between DNA-PK and ligase IV/XRCC4

    Hsu, Hsin-Ling; Yannone, Steven M.; Chen, David J.

    2001-04-10

    Non-homologous end joining (NHEJ) is a major pathway for the repair of DNA double-strand breaks in mammalian cells. DNA-dependent protein kinase (DNA-PK), ligase IV, and XRCC4 are all critical components of the NHEJ repair pathway. DNA-PK is composed of a heterodimeric DNA-binding component, Ku, and a large catalytic subunit, DNA-PKcs. Ligase IV and XRCC4 associate to form a multimeric complex that is also essential for NHEJ. DNA-PK and ligase IV/XRCC4 interact at DNA termini which results in stimulated ligase activity. Here we define interactions between the components of these two essential complexes, DNA-PK and ligase IV/XRCC4. We find that ligase IV/XRCC4 associates with DNA-PK in a DNA-independent manner. The specific protein-protein interactions that mediate the interaction between these two complexes are further identified. Direct physical interactions between ligase IV and Ku as well as between XRCC4 and DNA-PKcs are shown. No direct interactions are observed between ligase IV and DNA-PKcs or between XRCC4 and Ku. Our data defines the specific protein pairs involved in the association of DNA-PK and ligase IV/XRCC4, and suggests a molecular mechanism for coordinating the assembly of the DNA repair complex at DNA breaks.

  6. 30 CFR 57.22105 - Smoking and open flames (IV mines).

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Smoking and open flames (IV mines). 57.22105... Standards for Methane in Metal and Nonmetal Mines Fire Prevention and Control § 57.22105 Smoking and open flames (IV mines). Smoking or open flames shall not be permitted in a face or raise, or during release...

  7. 76 FR 58020 - Prescription Drug User Fee Act IV Information Technology Plan

    2011-09-19

    ... HUMAN SERVICES Food and Drug Administration Prescription Drug User Fee Act IV Information Technology... exchange, review, and management of information supporting the process for the review of human drug... Drug User Fee Act (PDUFA) IV Information Technology Plan'' (June 2008 plan). This updated plan...

  8. An experimental comparative study of radiography, ultrasonography and CT imaging in the IV catheter fragment

    Kweon, Dae Cheol [Dept. of Radiological Science, College of Health Science, Shinhan University, Uijeongbu (Korea, Republic of)

    2016-06-15

    The objective of this study was to detect the fragments generated during IV (intravenous) catheter injection of contrast medium and drug administration in a clinical setting and removal was performed by experimentally producing a phantom, and to compare the radiography, ultrasonography, and multi-detector computed tomography (MDCT) imaging and radiation dose. A 1 cm fragment of an 18 gage Teflon® IV catheter with saline was inserted into the IV control line. Radiography, CT, and ultrasonography were performed and radiography and CT dose were calculated. CT and ultrasonography showed an IV catheter fragment clinically and radiography showed no visible difference in the ability to provide a useful image of an IV catheter fragment modality (p >.05). Radiography of effective dose (0.2139 mSv·Gy-1·cm-2) form DAP DAP (0.93 μGy·m2 ), and dose length product (DLP) (201 mGy·cm) to effective dose was calculated as 0.483 mSv. IV catheter fragment were detected of radiography, ultrasonography and CT. These results can be obtained by menas of an excellent IV catheter fragment of detection capability CT. However, CT is followed by radiation exposure. IV catheter fragment confirming the position and information recommend an ultrasonography.

  9. Plutonium(IV) precipitates formed in alkaline media in the presence of various anions

    Krot, N.N.; Shilov, V.P.; Yusov, A.B.; Tananaev, I.G.; Grigoriev, M.S.; Garnov, A.Yu.; Perminov, V.P.; Astafurova, L.N.

    1998-09-01

    The tendency of Pu(IV) to hydrolyze and form true solutions, colloid solutions, or insoluble precipitates has been known since the Manhattan Project. Since then, specific studies have been performed to examine in detail the equilibria of Pu(IV) hydrolytic reactions in various media. Great attention also has been paid to the preparation, structure, and properties of Pu(IV) polymers or colloids. These compounds found an important application in sol-gel technology for the preparation of nuclear fuel materials. A most important result of these works was the conclusion that Pu(IV) hydroxide, after some aging, consists of very small PuO{sub 2} crystallites and should therefore be considered to be Pu(IV) hydrous oxide. However, studies of the properties and behavior of solid Pu(IV) hydroxide in complex heterogeneous systems are rare. The primary goal of this investigation was to obtain data on the composition and properties of Pu(IV) hydrous oxide or other compounds formed in alkaline media under different conditions. Such information is important to understand Pu(IV) behavior and the forms of its existence in the Hanford Site alkaline tank waste sludge. This knowledge then may be applied in assessing plutonium criticality hazards in the storage, retrieval, and treatment of Hanford Site tank wastes as well as in understanding its contribution to the transuranic waste inventory (threshold at 100 nCi/g or about 5 {times} 10{sup {minus}6} M) of the separate solution and solid phases.

  10. An Item Response Theory Analysis of DSM-IV Conduct Disorder

    Gelhorn, Heather; Hartman, Christie; Sakai, Joseph; Mikulich-Gilbertson, Susan; Stallings, Michael; Young, Susan; Rhee, Soo; Corley, Robin; Hewitt, John; Hopfer, Christian; Crowley, Thomas

    2009-01-01

    Interviews with over 3,000 adolescents were made to evaluate the extent to which DSM-IV criteria characterizes the range of severity of adolescent antisocial behavior within and across sex. The DSM-IV conduct disorder (CD) criteria are a useful indicator of severe adolescent antisocial behavior but some CD criteria display sex bias.

  11. Plutonium(IV) complexation by diglycolamide ligands - coordination chemistry insight into TODGA-based actinide separations

    Reilly, S.D.; Gaunt, A.J.; Scott, B.L.; Modolo, G.; Iqbal, M.; Verboom, W.; Sarsfield, M.J.

    2012-01-01

    Complexation of Pu(IV) with TMDGA, TEDGA, and TODGA diglycolamide ligands was followed by vis-NIR spectroscopy. A crystal structure determination reveals that TMDGA forms a 1:3 homoleptic Pu(IV) complex with the nitrate anions forced into the outer coordination sphere

  12. Analysis of Phoenix Anomalies and IV & V Findings Applied to the GRAIL Mission

    Larson, Steve

    2012-01-01

    NASA IV&V was established in 1993 to improve safety and cost-effectiveness of mission critical software. Since its inception the tools and strategies employed by IV&V have evolved. This paper examines how lessons learned from the Phoenix project were developed and applied to the GRAIL project. Shortly after selection, the GRAIL project initiated a review of the issues documented by IV&V for Phoenix. The motivation was twofold: the learn as much as possible about the types of issues that arose from the flight software product line slated for use on GRAIL, and to identify opportunities for improving the effectiveness of IV&V on GRAIL. The IV&V Facility provided a database dump containing 893 issues. These were categorized into 16 bins, and then analyzed according to whether the project responded by changing the affected artifacts or using as-is. The results of this analysis were compared to a similar assessment of post-launch anomalies documented by the project. Results of the analysis were discussed with the IV&V team assigned to GRAIL. These discussions led to changes in the way both the project and IV&V approached the IV&V task, and improved the efficiency of the activity.

  13. Can children undergoing ophthalmologic examinations under anesthesia be safely anesthetized without using an IV line?

    Vigoda M

    2011-04-01

    Full Text Available Michael M Vigoda, Azeema Latiff, Timothy G Murray, Jacqueline L Tutiven, Audina M Berrocal, Steven GayerBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USAPurpose: To document that with proper patient and procedure selection, children undergoing general inhalational anesthesia for ophthalmologic exams (with or without photos, ultrasound, laser treatment, peri-ocular injection of chemotherapy, suture removal, and/or replacement of ocular prosthesis can be safely anesthetized without the use of an intravenous (IV line. Children are rarely anesthetized without IV access placement. We performed a retrospective study to determine our incidence of IV access placement during examinations under anesthesia (EUA and the incidence of adverse events that required intraoperative IV access placement.Methods: Data collected from our operating room (OR information system includes but is not limited to diagnosis, anesthesiologist, surgeon, and location of IV catheter (if applicable, patient’s date of birth, actual procedure, and anesthesia/procedure times. We reviewed the OR and anesthetic records of children (>1 month and <10 years who underwent EUAs between January 1, 2003 and May 31, 2009. We determined the percentage of children who were anesthetized without IV access placement, as well as the incidence of any adverse events that required IV access placement, intraoperatively.Results: We analyzed data from 3196 procedures performed during a 77-month period. Patients’ ages ranged from 1 month to 9 years. Overall, 92% of procedures were performed without IV access placement. Procedure duration ranged from 1–39 minutes. Reasons for IV access placement included parental preference for antinausea medication and/or attending preference for IV access placement. No child who underwent anesthesia without an IV line had an intraoperative adverse event requiring insertion of an IV line.Conclusion: Our data suggest that for

  14. Type-IV DCT, DST, and MDCT algorithms with reduced numbers of arithmetic operations

    Shao, Xuancheng

    2007-01-01

    We present algorithms for the type-IV discrete cosine transform (DCT-IV) and discrete sine transform (DST-IV), as well as for the modified discrete cosine transform (MDCT) and its inverse, that achieve a lower count of real multiplications and additions than previously published algorithms, without sacrificing numerical accuracy. Asymptotically, the operation count is reduced from ~2NlogN to ~(17/9)NlogN for a power-of-two transform size N. These results are derived by considering the DCT to be a special case of a DFT of length 8N, with certain symmetries, and then pruning redundant operations from a recent improved fast Fourier transform algorithm (based on a recursive rescaling of the conjugate-pair split radix algorithm). The improved algorithms for DST-IV and MDCT follow immediately from the improved count for the DCT-IV.

  15. The formation of hydrophilic Np(IV) complexes and their potential application in nuclear fuel reprocessing

    May, I.; Taylor, R.J.; Brown, G. [British Nuclear Fuels Ltd., Sellafield (United Kingdom)

    1998-06-12

    A series of organic ligands have been screened for their effectiveness as complexants for Np(IV) in a neptunium rejection stage of an advanced PUREX process. Four of these species, formohydroxamic acid, acetohydroxamic acid, glycolic acid and pyruvic acid, readily form hydrophilic complexes with Np(IV) and can strip the actinide from 30% TBP/OK (30% tributylphosphate in odourless kerosene) into nitric acid. Near infra-red spectroscopy has been used to monitor Np(IV) complexation in nitric acid. Distribution experiments have been undertaken between nitric acid and 30% TBP/OK to examine the effect of ligand and nitric acid concentration on Np(IV) stripping. Finally, it has been shown that the extractability of U(VI) is unaffected by the presence of these ligands and all can be used to selectively strip Np(IV) from a U(VI) product stream in an advanced PUREX process. (orig.) 11 refs.

  16. Monitoring and Fault Detection in Photovoltaic Systems Based On Inverter Measured String I-V Curves

    Spataru, Sergiu; Sera, Dezso; Kerekes, Tamas;

    2015-01-01

    Most photovoltaic (PV) string inverters have the hardware capability to measure at least part of the current-voltage (I-V) characteristic curve of the PV strings connected at the input. However, this intrinsic capability of the inverters is not used, since I-V curve measurement and monitoring......-of-system components through increased series resistance losses, or shunting of the PV modules. To achieve this, we propose and experimentally demonstrate three complementary PV system monitoring methods that make use of the I-V curve measurement capability of a commercial string inverter. The first method is suitable...... for monitoring single or independent PV strings, and is based on evaluating the ratio of certain operation points on the string I-V curve. The second method is applicable to PV systems with identical strings, and is based on monitoring and inter-comparison of string I-V curve parameters. For PV systems with non...

  17. Functional Diversification of Maize RNA Polymerase IV and V subtypes via Alternative Catalytic Subunits

    Haag, Jeremy R.; Brower-Toland, Brent; Krieger, Elysia K.; Sidorenko, Lyudmila; Nicora, Carrie D.; Norbeck, Angela D.; Irsigler, Andre; LaRue, Huachun; Brzeski, Jan; Mcginnis, Karen A.; Ivashuta, Sergey; Pasa-Tolic, Ljiljana; Chandler, Vicki L.; Pikaard, Craig S.

    2014-10-01

    Unlike nuclear multisubunit RNA polymerases I, II, and III, whose subunit compositions are conserved throughout eukaryotes, plant RNA polymerases IV and V are nonessential, Pol II-related enzymes whose subunit compositions are still evolving. Whereas Arabidopsis Pols IV and V differ from Pol II in four or five of their 12 subunits, respectively, and differ from one another in three subunits, proteomic ana- lyses show that maize Pols IV and V differ from Pol II in six subunits but differ from each other only in their largest subunits. Use of alternative catalytic second subunits, which are nonredundant for development and paramutation, yields at least two sub- types of Pol IV and three subtypes of Pol V in maize. Pol IV/Pol V associations with MOP1, RMR1, AGO121, Zm_DRD1/CHR127, SHH2a, and SHH2b extend parallels between paramutation in maize and the RNA-directed DNA methylation pathway in Arabidopsis.

  18. Factors influencing response to intravenous lacosamide in emergency situations: LACO-IV study.

    Garcés, Mercedes; Villanueva, Vicente; Mauri, José Angel; Suller, Ana; García, Carolina; López González, Franscisco Javier; Rodríguez Osorio, Xiana; Fernández Pajarín, Gustavo; Piera, Anna; Guillamón, Edelmira; Santafé, Consuelo; Castillo, Ascensión; Giner, Pau; Torres, Nerea; Escalza, Inés; Del Villar, Ana; García de Casasola, Maria Carmen; Bonet, Macarena; Noé, Enrique; Olmedilla, Nuria

    2014-07-01

    Status epilepticus (SE) and acute repetitive seizures (ARSs) frequently result in emergency visits. Wide variations in response are seen with standard antiepileptic drugs (AEDs). Oral and intravenous (IV) formulations of lacosamide are approved as adjunctive therapy in the treatment of partial-onset seizures in adults and adolescents. The aim of the retrospective multicenter observational study (LACO-IV) was to analyze data from a large cohort of patients with SE or ARSs of varying severity and etiology, who received IV lacosamide in the emergency setting. Patient clinical data were entered into a database; lacosamide use and efficacy and tolerability variables were analyzed. In SE, IV lacosamide tended to be used mainly in nonconvulsive status epilepticus as second- or third-line treatment. The proportion of patients with no seizures when IV lacosamide was the last drug administered was 76.5% (70.9% SE and 83.7% ARSs). The rate of seizure cessation ≤ 24 h after IV lacosamide administration was 57.1% (49.1% SE and 67.4% ARSs). Of the factors analyzed, a shorter latency from seizure onset to IV lacosamide infusion influenced treatment response significantly. A nonsignificant tendency towards a higher response was seen with lacosamide dose >200mg versus ≤ 200 mg. Analysis of response according to mechanism of action showed no significant differences in response to IV lacosamide in patients receiving prior sodium channel blocker (SCB) or non-SCB AEDs in the overall or SE population; however, in ARSs, a tendency towards a higher response was observed in those receiving non-SCB AEDs. The frequency and nature of adverse events observed were in line with those reported in other studies (somnolence being the most frequent). In the absence of randomized prospective controlled studies of IV lacosamide, our observations suggest that IV lacosamide may be a potential alternative for treatment of SE/ARSs when seizures fail to improve with standard AEDs or when AEDs are

  19. The product of microbial uranium reduction includes multiple species with U(IV)-phosphate coordination

    Alessi, Daniel S.; Lezama-Pacheco, Juan S.; Stubbs, Joanne E.; Janousch, Markus; Bargar, John R.; Persson, Per; Bernier-Latmani, Rizlan

    2014-04-01

    Until recently, the reduction of U(VI) to U(IV) during bioremediation was assumed to produce solely the sparingly soluble mineral uraninite, UO2(s). However, results from several laboratories reveal other species of U(IV) characterized by the absence of an EXAFS U-U pair correlation (referred to here as noncrystalline U(IV)). Because it lacks the crystalline structure of uraninite, this species is likely to be more labile and susceptible to reoxidation. In the case of single species cultures, analyses of U extended X-ray fine structure (EXAFS) spectra have previously suggested U(IV) coordination to carboxyl, phosphoryl or carbonate groups. In spite of this evidence, little is understood about the species that make up noncrystalline U(IV), their structural chemistry and the nature of the U(IV)-ligand interactions. Here, we use infrared spectroscopy (IR), uranium LIII-edge X-ray absorption spectroscopy (XAS), and phosphorus K-edge XAS analyses to constrain the binding environments of phosphate and uranium associated with Shewanella oneidensis MR-1 bacterial cells. Systems tested as a function of pH included: cells under metal-reducing conditions without uranium, cells under reducing conditions that produced primarily uraninite, and cells under reducing conditions that produced primarily biomass-associated noncrystalline U(IV). P X-ray absorption near-edge structure (XANES) results provided clear and direct evidence of U(IV) coordination to phosphate. Infrared (IR) spectroscopy revealed a pronounced perturbation of phosphate functional groups in the presence of uranium. Analysis of these data provides evidence that U(IV) is coordinated to a range of phosphate species, including monomers and polymerized networks. U EXAFS analyses and a chemical extraction measurements support these conclusions. The results of this study provide new insights into the binding mechanisms of biomass-associated U(IV) species which in turn sheds light on the mechanisms of biological U

  20. Tissue sites of degradation of high density lipoprotein apolipoprotein A-IV in rats

    Dallinga-Thie, G.M.; Van ' t Hooft, F.M.; Van Tol, A.

    1986-05-01

    The in vivo metabolism of high density lipoprotein (HDL), labeled by incorporation of /sup 125/I-apolipoprotein (apo) A-IV, was studied in the rat and compared with the metabolism of HDL labeled with 131I-apo A-I. The /sup 125/I-apo A-IV labeled HDL was obtained by adding small amounts of radioiodinated apo A-IV to rat serum, followed by separation of the different lipoprotein fractions by chromatography on 6% agarose columns in order to avoid stripping of apolipoproteins by ultracentrifugation. Under both in vitro and in vivo conditions, the /sup 125/I-apo A-IV remained an integral component of HDL and was not exchanged to other lipoproteins, including the free apo A-IV fraction. The serum half-life, measured at between 8 and 28 hours after intravenous injection of labeled HDL, was 8.5 +/- 0.5 hours for HDL apo A-IV and 10.2 +/- 0.7 hours for HDL apo A-I. The tissue sites of catabolism of HDL apo A-IV and HDL apo A-I were analyzed in the leupeptin-model. Only the kidneys and liver showed a significant leupeptin-dependent accumulation of radioactivity. At 4 hours after injection of 125I-apo A-IV/131I-apo A-I labeled HDL, 3.5% +/- 1.0% and 8.4% +/- 2.0% of HDL apo A-IV and 4.6% +/- 1.3% and 2.6% +/- 0.6% of the HDL apo A-I were accumulated in a leupeptin-dependent process in the kidneys and liver, respectively. Immunocytochemical studies revealed that the renal localization of apo A-IV was intracellular and confined to the epithelial cells of the proximal tubuli.

  1. C-Terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin.

    Liu, Sicheng; Liu, Xunyue; Kamdar, Radhika Pankaj; Wanotayan, Rujira; Sharma, Mukesh Kumar; Adachi, Noritaka; Matsumoto, Yoshihisa

    2013-09-20

    DNA ligase IV (LIG4) and XRCC4 form a complex to ligate two DNA ends at the final step of DNA double-strand break (DSB) repair through non-homologous end-joining (NHEJ). It is not fully understood how these proteins are recruited to DSBs. We recently demonstrated radiation-induced chromatin binding of XRCC4 by biochemical fractionation using detergent Nonidet P-40. In the present study, we examined the role of LIG4 in the recruitment of XRCC4/LIG4 complex to chromatin. The chromatin binding of XRCC4 was dependent on the presence of LIG4. The mutations in two BRCT domains (W725R and W893R, respectively) of LIG4 reduced the chromatin binding of LIG4 and XRCC4. The C-terminal fragment of LIG4 (LIG4-CT) without N-terminal catalytic domains could bind to chromatin with XRCC4. LIG4-CT with W725R or W893R mutation could bind to chromatin but could not support the chromatin binding of XRCC4. The ability of C-terminal region of LIG4 to interact with chromatin might provide us with an insight into the mechanisms of DSB repair through NHEJ.

  2. Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme.

    Diez-Torrubia, Alberto; Cabrera, Silvia; de Castro, Sonia; García-Aparicio, Carlos; Mulder, Gwenn; De Meester, Ingrid; Camarasa, María-José; Balzarini, Jan; Velázquez, Sonsoles

    2013-01-01

    We herein report for the first time the successful use of the dipeptidyl peptidase IV (DPPIV/CD26) prodrug approach to guanine derivatives such as the antiviral acyclovir (ACV). The solution- and solid-phase synthesis of the tetrapeptide amide prodrug 3 and the tripeptide ester conjugate 4 of acyclovir are reported. The synthesis of the demanding tetrapeptide amide prodrug of ACV 3 was first established in solution and successfully transferred onto solid support by using Ellman's dihydropyran (DHP) resin. In contrast with the valyl ester prodrug (valacyclovir, VACV), the tetrapeptide amide prodrug 3 and the tripeptide ester conjugate 4 of ACV proved fully stable in PBS. Both prodrugs converted to VACV (for 4) or ACV (for 3) upon exposure to purified DPPIV/CD26 or human or bovine serum. Vildagliptin, a potent inhibitor of DPPIV/CD26 efficiently inhibited the DPPIV/CD26-catalysed hydrolysis reaction. Both amide and ester prodrugs of ACV showed pronounced anti-herpetic activity in cell culture and significantly improved the water solubility in comparison with the parent drug.

  3. Evolution of conjugation and type IV secretion systems.

    Guglielmini, Julien; de la Cruz, Fernando; Rocha, Eduardo P C

    2013-02-01

    Genetic exchange by conjugation is responsible for the spread of resistance, virulence, and social traits among prokaryotes. Recent works unraveled the functioning of the underlying type IV secretion systems (T4SS) and its distribution and recruitment for other biological processes (exaptation), notably pathogenesis. We analyzed the phylogeny of key conjugation proteins to infer the evolutionary history of conjugation and T4SS. We show that single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) conjugation, while both based on a key AAA(+) ATPase, diverged before the last common ancestor of bacteria. The two key ATPases of ssDNA conjugation are monophyletic, having diverged at an early stage from dsDNA translocases. Our data suggest that ssDNA conjugation arose first in diderm bacteria, possibly Proteobacteria, and then spread to other bacterial phyla, including bacterial monoderms and Archaea. Identifiable T4SS fall within the eight monophyletic groups, determined by both taxonomy and structure of the cell envelope. Transfer to monoderms might have occurred only once, but followed diverse adaptive paths. Remarkably, some Firmicutes developed a new conjugation system based on an atypical relaxase and an ATPase derived from a dsDNA translocase. The observed evolutionary rates and patterns of presence/absence of specific T4SS proteins show that conjugation systems are often and independently exapted for other functions. This work brings a natural basis for the classification of all kinds of conjugative systems, thus tackling a problem that is growing as fast as genomic databases. Our analysis provides the first global picture of the evolution of conjugation and shows how a self-transferrable complex multiprotein system has adapted to different taxa and often been recruited by the host. As conjugation systems became specific to certain clades and cell envelopes, they may have biased the rate and direction of gene transfer by conjugation within prokaryotes.

  4. SDSS-IV/MaNGA: Spectrophotometric Calibration Technique

    Yan, Renbin; Tremonti, Christy; Bershady, Matthew A.; Law, David R.; Schlegel, David J.; Bundy, Kevin; Drory, Niv; MacDonald, Nicholas; Bizyaev, Dmitry; Blanc, Guillermo A.; Blanton, Michael R.; Cherinka, Brian; Eigenbrot, Arthur; Gunn, James E.; Harding, Paul; Hogg, David W.; Sánchez-Gallego, José R.; Sánchez, Sebastian F.; Wake, David A.; Weijmans, Anne-Marie; Xiao, Ting; Zhang, Kai

    2016-01-01

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA), one of three core programs in the Sloan Digital Sky Survey-IV, is an integral-field spectroscopic survey of roughly 10,000 nearby galaxies. It employs dithered observations using 17 hexagonal bundles of 2″ fibers to obtain resolved spectroscopy over a wide wavelength range of 3600-10300 Å. To map the internal variations within each galaxy, we need to perform accurate spectral surface photometry, which is to calibrate the specific intensity at every spatial location sampled by each individual aperture element of the integral field unit. The calibration must correct only for the flux loss due to atmospheric throughput and the instrument response, but not for losses due to the finite geometry of the fiber aperture. This requires the use of standard star measurements to strictly separate these two flux loss factors (throughput versus geometry), a difficult challenge with standard single-fiber spectroscopy techniques due to various practical limitations. Therefore, we developed a technique for spectral surface photometry using multiple small fiber-bundles targeting standard stars simultaneously with galaxy observations. We discuss the principles of our approach and how they compare to previous efforts, and we demonstrate the precision and accuracy achieved. MaNGA's relative calibration between the wavelengths of Hα and Hβ has an rms of 1.7%, while that between [N ii] λ6583 and [O ii] λ3727 has an rms of 4.7%. Using extinction-corrected star formation rates and gas-phase metallicities as an illustration, this level of precision guarantees that flux calibration errors will be sub-dominant when estimating these quantities. The absolute calibration is better than 5% for more than 89% of MaNGA's wavelength range.

  5. SDSS-IV MaNGA: Survey Design and Progress

    Yan, Renbin; MaNGA Team

    2016-01-01

    The ongoing SDSS-IV/MaNGA Survey will obtain integral field spectroscopy at a resolution of R~2000 with a wavelength coverage from 3,600A to 10,300A for 10,000 nearby galaxies. Within each 3 degree diameter pointing of the 2.5m Sloan Telescope, we deploy 17 hexagonal fiber bundles with sizes ranging from 12 to 32 arcsec in diameter. The bundles are build with 2 arcsec fibers and have a 56% fill factor. During observations, we obtained sets of exposures at 3 different dither positions to achieve near-critical sampling of the effective point spread function, which has a FWHM about 2.5 arcsec, corresponding to 1-2 kpc for the majority of the galaxies targeted. The flux calibration is done using 12 additional mini-fiber-bundles targeting standard stars simultaneously with science targets, achieving a calibration accuracy better than 5% over 90% of the wavelength range. The target galaxies are selected to ensure uniform spatial coverage in units of effective radii for the majority of the galaxies while maximizing spatial resolution. About 2/3 of the sample is covered out to 1.5Re (primary sample) and 1/3 of the sample covered to 2.5Re (secondary sample). The sample is designed to have approximately equal representation from high and low mass galaxies while maintaining volume-limited selection at fixed absolute magnitudes. We obtain an average S/N of 4 per Angstrom in r-band continuum at a surface brightness of 23 AB arcsec-2. With spectral stacking in an elliptical annulus covering 1-1.5Re, our primary sample galaxies have a median S/N of ~60 per Angstrom in r-band.

  6. Structural Characterization of Novel Pseudomonas aeruginosa Type IV Pilins

    Nguyen, Y.; Jackson, S; Aidoo, F; Junop, M; Burrows, L

    2010-01-01

    Pseudomonas aeruginosa type IV pili, composed of PilA subunits, are used for attachment and twitching motility on surfaces. P. aeruginosa strains express one of five phylogenetically distinct PilA proteins, four of which are associated with accessory proteins that are involved either in pilin posttranslational modification or in modulation of pilus retraction dynamics. Full understanding of pilin diversity is crucial for the development of a broadly protective pilus-based vaccine. Here, we report the 1.6-{angstrom} X-ray crystal structure of an N-terminally truncated form of the novel PilA from strain Pa110594 (group V), which represents the first non-group II pilin structure solved. Although it maintains the typical T4a pilin fold, with a long N-terminal {alpha}-helix and four-stranded antiparallel {beta}-sheet connected to the C-terminus by a disulfide-bonded loop, the presence of an extra helix in the {alpha}{beta}-loop and a disulfide-bonded loop with helical character gives the structure T4b pilin characteristics. Despite the presence of T4b features, the structure of PilA from strain Pa110594 is most similar to the Neisseria gonorrhoeae pilin and is also predicted to assemble into a fiber similar to the GC pilus, based on our comparative pilus modeling. Interactions between surface-exposed areas of the pilin are suggested to contribute to pilus fiber stability. The non-synonymous sequence changes between group III and V pilins are clustered in the same surface-exposed areas, possibly having an effect on accessory protein interactions. However, based on our high-confidence model of group III PilA{sub PA14}, compensatory changes allow for maintenance of a similar shape.

  7. The BALDER Beamline at the MAX IV Laboratory

    Klementiev, K.; Norén, K.; Carlson, S.; Sigfridsson Clauss, K. G. V.; Persson, I.

    2016-05-01

    X-ray absorption spectroscopy (XAS) includes well-established methods to study the local structure around the absorbing element - extended X-ray absorption fine structure (EXAFS), and the effective oxidation number or to quantitatively determine the speciation of an element in a complex matrix - X-ray absorption near-edge structure (XANES). The increased brilliance and intensities available at the new generation of synchrotron light sources makes it possible to study, in-situ and in-operando, much more dilute systems with relevance for natural systems, as well as the micro-scale variability and dynamics of chemical reactions on the millisecond time-scale. The design of the BALDER beamline at the MAX IV Laboratory 3 GeV ring has focused on a high flux of photons in a wide energy range, 2.4-40 keV, where the K-edge is covered for the elements S to La, and the L 3-edge for all elements heavier than Sb. The overall design of the beamline will allow large flexibility in energy range, beam size and data collection time. The other focus of the beamline design is the possibility to perform multi-technique analyses on samples. Development of sample environment requires focus on implementation of auxiliary methods in such a way that techniques like Fourier transform infrared (FTIR) spectroscopy, UV-Raman spectroscopy, X-ray diffraction and/or mass spectrometry can be performed simultaneously as the XAS study. It will be a flexible system where different instruments can be plugged in and out depending on the needs for the particular investigation. Many research areas will benefit from the properties of the wiggler based light source and the capabilities to perform in-situ and in-operando measurements, for example environmental and geochemical sciences, nuclear chemistry, catalysis, materials sciences, and cultural heritage.

  8. Chaperone-mediated autophagy is defective in mucolipidosis type IV.

    Venugopal, Bhuvarahamurthy; Mesires, Nicholas T; Kennedy, John C; Curcio-Morelli, Cyntia; Laplante, Janice M; Dice, J Fred; Slaugenhaupt, Susan A

    2009-05-01

    Mucolipidosis type IV (MLIV) is a lysosomal storage disorder caused by mutations in the MCOLN1 gene, a member of the transient receptor potential (TRP) cation channel gene family. The encoded protein, transient receptor potential mucolipin-1 (TRPML1), has been localized to lysosomes and late endosomes but the pathogenic mechanism by which loss of TRPML1 leads to abnormal cellular storage and neuronal cell death is still poorly understood. Yeast two-hybrid and co-immunoprecipitation (coIP) experiments identified interactions between TRPML1 and Hsc70 as well as TRPML1 and Hsp40. Hsc70 and Hsp40 are members of a molecular chaperone complex required for protein transport into the lysosome during chaperone-mediated autophagy (CMA). To determine the functional relevance of this interaction, we compared fibroblasts from MLIV patients to those from sex- and age-matched controls and show a defect in CMA in response to serum withdrawal. This defect in CMA was subsequently confirmed in purified lysosomes isolated from control and MLIV fibroblasts. We further show that the amount of lysosomal-associated membrane protein type 2A (LAMP-2A) is reduced in lysosomal membranes of MLIV fibroblasts. As a result of decreased CMA, MLIV fibroblasts have increased levels of oxidized proteins compared to control fibroblasts. We hypothesize that TRPML1 may act as a docking site for intralysosomal Hsc70 (ly-Hsc70) allowing it to more efficiently pull in substrates for CMA. It is also possible that TRPML1 channel activity may be required for CMA. Understanding the role of TRPML1 in CMA will undoubtedly help to characterize the pathogenesis of MLIV.

  9. SDSS-IV/MaNGA: SPECTROPHOTOMETRIC CALIBRATION TECHNIQUE

    Yan, Renbin; Sánchez-Gallego, José R. [Department of Physics and Astronomy, University of Kentucky, 505 Rose St., Lexington, KY 40506-0057 (United States); Tremonti, Christy; Bershady, Matthew A.; Eigenbrot, Arthur; Wake, David A. [Department of Astronomy, University of Winsconsin-Madison, 475 N. Charter Street, Madison, WI 53706-1582 (United States); Law, David R. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Schlegel, David J. [Physics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720-8160 (United States); Bundy, Kevin [Kavli IPMU (WPI), UTIAS, The University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Drory, Niv [McDonald Observatory, Department of Astronomy, University of Texas at Austin, 1 University Station, Austin, TX 78712-0259 (United States); MacDonald, Nicholas [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Bizyaev, Dmitry [Apache Point Observatory, P.O. Box 59, sunspot, NM 88349 (United States); Blanc, Guillermo A. [Departamento de Astronomía, Universidad de Chile, Camino el Observatorio 1515, Las Condes, Santiago (Chile); Blanton, Michael R.; Hogg, David W. [Center for Cosmology and Particle Physics, Department of Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); Cherinka, Brian [Dunlap Institute for Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, Ontario M5S 3H4 (Canada); Gunn, James E. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Harding, Paul [Department of Astronomy, Case Western Reserve University, Cleveland, OH 44106 (United States); Sánchez, Sebastian F., E-mail: yanrenbin@uky.edu [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, A.P. 70-264, 04510 Mexico D.F. (Mexico); and others

    2016-01-15

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA), one of three core programs in the Sloan Digital Sky Survey-IV, is an integral-field spectroscopic survey of roughly 10,000 nearby galaxies. It employs dithered observations using 17 hexagonal bundles of 2″ fibers to obtain resolved spectroscopy over a wide wavelength range of 3600–10300 Å. To map the internal variations within each galaxy, we need to perform accurate spectral surface photometry, which is to calibrate the specific intensity at every spatial location sampled by each individual aperture element of the integral field unit. The calibration must correct only for the flux loss due to atmospheric throughput and the instrument response, but not for losses due to the finite geometry of the fiber aperture. This requires the use of standard star measurements to strictly separate these two flux loss factors (throughput versus geometry), a difficult challenge with standard single-fiber spectroscopy techniques due to various practical limitations. Therefore, we developed a technique for spectral surface photometry using multiple small fiber-bundles targeting standard stars simultaneously with galaxy observations. We discuss the principles of our approach and how they compare to previous efforts, and we demonstrate the precision and accuracy achieved. MaNGA's relative calibration between the wavelengths of Hα and Hβ has an rms of 1.7%, while that between [N ii] λ6583 and [O ii] λ3727 has an rms of 4.7%. Using extinction-corrected star formation rates and gas-phase metallicities as an illustration, this level of precision guarantees that flux calibration errors will be sub-dominant when estimating these quantities. The absolute calibration is better than 5% for more than 89% of MaNGA's wavelength range.

  10. Role in fast inactivation of conserved amino acids in the IV/S4-S5 loop of the human muscle Na+ channel.

    Mitrovic, N; Lerche, H; Heine, R; Fleischhauer, R; Pika-Hartlaub, U; Hartlaub, U; George, A L; Lehmann-Horn, F

    1996-08-16

    Since it has been shown that point mutations in the S4-S5 loop of the Shaker K+ channel may disrupt fast inactivation, we investigated the role of three conserved amino acids in IV/S4-S5 of the adult human muscle Na+ channel (L1471, S1478, L1482). In contrast to the K+ channel mutations, the analogous substitutions in the Na+ channel (S1478A/C, L1482A) did not substantially affect fast inactivation. Nevertheless, the mutations S1478A/C/Q shifted the voltage dependence of steady-state inactivation; L1471Q and S1478C slowed recovery from inactivation. In contrast, a novel non-conserved IV/S4-S5 mutation causing paramyotonia congenita (F1473S) slowed fast inactivation 2-fold and accelerated recovery from inactivation 5-fold. The results indicate involvement of the IV/ S4-S5 loop of the human muscle Na+ channel in fast inactivation, but different roles for conserved amino acids among Na+ and K+ channels.

  11. THE EFFECT OF STANUM (IV AND GERMANІUM (IV COORDINATION COMPOUNDS ON Bacillus thuringiensis var. israelensis ІМV В-7465 PEPTIDASES ACTIVITY

    Nidialkova N. А.

    2015-08-01

    Full Text Available The purpose of the research was to investigate the influence of stanum (IV and germanium (IV coordination compounds on peptidases 1 and 2 of Bacillus thuringiensis var. israelensis ІМV В-7465 activity. The study of coordination compounds effect on peptidase activity was carried out by complexes with the enzymes incubation and residual activity to the collagen, elastin and fibrin determination. It was revealed the regularity in the influence of different structure complex compounds on peptidases of B. thuringiensis var. israelensis ІМV В-7465 activity. The stanum (IV complexes with salicyloylhydrazones of aromatic aldehydes increase collagenase and elastase activities. Substituents replacement in aldehyde fragment of stanum (IV with isonicotinoylhydrazones of aromatic aldehydes complexes by the less polar ones contributed to increase of elastase activity of both enzymes while an absence of substituents enables to increase peptidase 2 fibrinolytic activity. The complexes of germanіum (IV with isonicotinoylhydrazone of salicylic aldehyde which contain Zn and Co, increased collagenase activity of the peptidase 1 as well as elastase and fibrinolytic activities of the peptidase 2. In general, all tested complexes may be considered as peptidase effectors of B. thuringiensis var. israelensis ІМV В-7465. A difference of complexes effect on activities of the both enzymes is due to the characteristics of the structure of coordination compounds.

  12. Cryptic collagen IV promotes cell migration and adhesion in myeloid leukemia.

    Favreau, Amanda J; Vary, Calvin P H; Brooks, Peter C; Sathyanarayana, Pradeep

    2014-04-01

    Previously, we showed that discoidin domain receptor 1 (DDR1), a class of collagen-activated receptor tyrosine kinase (RTK) was highly upregulated on bone marrow (BM)-derived CD33+ leukemic blasts of acute myeloid leukemia (AML) patients. Herein as DDR1 is a class of collagen-activated RTK, we attempt to understand the role of native and remodeled collagen IV in BM microenvironment and its functional significance in leukemic cells. Exposure to denatured collagen IV significantly increased the migration and adhesion of K562 cells, which also resulted in increased activation of DDR1 and AKT. Further, levels of MMP9 were increased in conditioned media (CM) of denatured collagen IV exposed cells. Mass spectrometric liquid chromatography/tandem mass spectrometry QSTAR proteomic analysis revealed exclusive presence of Secretogranin 3 and InaD-like protein in the denatured collagen IV CM. Importantly, BM samples of AML patients exhibited increased levels of remodeled collagen IV compared to native as analyzed via anti-HUIV26 antibody. Taken together, for the first time, we demonstrate that remodeled collagen IV is a potent activator of DDR1 and AKT that also modulates both migration and adhesion of myeloid leukemia cells. Additionally, high levels of the HUIV26 cryptic collagen IV epitope are expressed in BM of AML patients. Further understanding of this phenomenon may lead to the development of therapeutic agents that directly modulate the BM microenvironment and attenuate leukemogenesis.

  13. Clinical significance of serum laminin and type-IV collagen levels in cutaneous melanoma patients.

    Tas, Faruk; Bilgin, Elif; Karabulut, Senem; Duranyildiz, Derya

    2016-07-01

    Laminin and type-IV collagen constitute a significant portion of the extracellular matrix. The objective of the present study was to evaluate whether the serum concentrations of laminin and type-IV collagen may serve as biomarkers for cutaneous melanoma. Sixty pathologically confirmed melanoma patients were enrolled in the study. Serum laminin and type-IV collagen levels were assessed using an ELISA. Thirty healthy controls were also examined. No significant differences in the baseline serum levels of laminin were identified between melanoma patients and healthy controls (P=0.45). However, the baseline serum levels of type-IV collagen were significantly elevated in melanoma patients compared with those in the control group (PIV collagen (P>0.05). Furthermore, the serum levels of laminin and type-IV collagen had no prognostic value regarding the outcome for melanoma patients (P=0.36 and P=0.26, respectively). While laminin levels showed no diagnostic value, the serum concentrations of type-IV collagen were indicated to serve as a diagnostic marker in patients with cutaneous melanoma. In conclusion, type-IV collagen levels may be used as a diagnostic marker for cutaneous melanoma, while being void of any prognostic value.

  14. DPP IV inhibitor blocks mescaline-induced scratching and amphetamine-induced hyperactivity in mice.

    Lautar, Susan L; Rojas, Camilo; Slusher, Barbara S; Wozniak, Krystyna M; Wu, Ying; Thomas, Ajit G; Waldon, Daniel; Li, William; Ferraris, Dana; Belyakov, Sergei

    2005-06-28

    Dipeptidyl peptidase IV (DPP IV) is a ubiquitous membrane-bound enzyme that cleaves the two N-terminal amino acids from peptides with a proline or alanine residue in the second position from the amino end. Potential substrates for DPP IV include several neuropeptides, suggesting a role for DPP IV in neurological processes. We have developed a potent DPP IV inhibitor (IC50 = 30 nM), 1-(2-amino-3-methyl-butyryl)-azetidine-2-carbonitrile (AMAC), which has shown efficacy in two established models of psychosis: mescaline-induced scratching and amphetamine-induced hyperactivity. In the mescaline-induced scratching model, AMAC treatment before mescaline administration reduced the number of scratching paroxysms by 68% (P < 0.01). The compound showed a dose-dependent effect, inhibiting significantly at 6, 20 and 60 mg/kg (37%, 39% and 68%, respectively). In the amphetamine-induced hyperactivity model, 50 and 60 mg/kg AMAC, given before injection of amphetamine, significantly reduced hyper-locomotion by 65% and 76%, respectively. Additionally, AMAC showed no significant activity in binding assays for 20 receptors thought to be involved in the pathology of schizophrenia, including dopamine, serotonin and glutamate. A structurally similar analog, 1-(2-dimethylamino-3-methyl-butyryl)-azetidine-2-carbonitrile (DAMAC), that does not inhibit DPP IV, was inactive in both models. Taken together, these data suggest that the antipsychotic effects of AMAC are the result of DPP IV inhibition.

  15. Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining

    Pablo De Ioannes

    2012-12-01

    Full Text Available DNA ligase IV (LigIV and Artemis are central components of the nonhomologous end-joining (NHEJ machinery that is required for V(DJ recombination and the maintenance of genomic integrity in mammalian cells. We report here crystal structures of the LigIV DNA binding domain (DBD in both its apo form and in complex with a peptide derived from the Artemis C-terminal region. We show that LigIV interacts with Artemis through an extended hydrophobic surface. In particular, we find that the helix α2 in LigIV-DBD is longer than in other mammalian ligases and presents residues that specifically interact with the Artemis peptide, which adopts a partially helical conformation on binding. Mutations of key residues on the LigIV-DBD hydrophobic surface abolish the interaction. Together, our results provide structural insights into the specificity of the LigIV-Artemis interaction and how the enzymatic activities of the two proteins may be coordinated during NHEJ.

  16. Solvent extraction separation of zirconium(IV from succinate media with N-n-octylaniline

    M. M. RAJMANE

    2006-03-01

    Full Text Available The extraction behavior of zirconium(IV from succinate (0.01 – 0.03 M medium (25 mL with 10 mL 3 % N-n-octylaniline in xylene was investigated. The pH range 3.7 – 5.0 was effective for the quantitative extraction of zirconium(IV. Zirconium(IV was back extracted with 0.5 M HNO3 (3 × 5 mL. The method was free from interferences of a large number of cations and anions. Zirconium(IV was separated from associated elements in its binary mixture with Mo(VI, Nb(V, Re(VII, La(III, Ti(IV, Th(IV and Al(III. The proposed method was applied to synthetic mixtures. The results of analysis indicate that trace amounts of zirconium(IV could be separated effectively from higher amounts of other elements. The method is simple, selective, rapid and eco-friendly.

  17. Infection control in IV therapy: a review of the chain of infection.

    Lavery, Irene

    The aim of this article is to review the principles of infection control relating to intravenous (IV) therapy. IV therapy and peripheral IV cannulation are common procedures. Zingg and Pittet (2009) noted that as many as 80% of hospitalized patients will have a cannula in situ, and Hart (2008) suggested that patients who require IV therapy are often seriously ill and immunocompromised, thus are more susceptible to infection. The Department of Health (DH) (2007a) estimated that 6000 patients acquire a catheter-related bloodstream infection every year in the UK. Robust standards of practice are therefore paramount to ensure safe and competent practice, both in peripheral IV cannulation and IV care. Using the chain of infection as a framework to review practice will enable practitioners to ensure thorough standards of practice, and the Royal College of Nursing (RCN) (2005) stated that only trained and competent staff using strict aseptic techniques should be involved in IV or cannulae care. Furthermore, the Code (Nursing and Midwifery Council (NMC), (2008) stipulates all practitioners must deliver care based on the best available evidence and/or best practice, and that knowledge and skills for safe and effective practice must be kept up-to-date throughout each health professional's working life.

  18. Hindbrain DPP-IV inhibition improves glycemic control and promotes negative energy balance.

    Mietlicki-Baase, Elizabeth G; McGrath, Lauren E; Koch-Laskowski, Kieran; Krawczyk, Joanna; Pham, Tram; Lhamo, Rinzin; Reiner, David J; Hayes, Matthew R

    2017-01-22

    The beneficial glycemic and food intake-suppressive effects of glucagon-like peptide-1 (GLP-1) have made this neuroendocrine system a leading target for pharmacological approaches to the treatment of diabetes and obesity. One strategy to increase the activity of endogenous GLP-1 is to prevent the rapid degradation of the hormone by the enzyme dipeptidyl peptidase-IV (DPP-IV). However, despite the expression of both DPP-IV and GLP-1 in the brain, and the clear importance of central GLP-1 receptor (GLP-1R) signaling for glycemic and energy balance control, the metabolic effects of central inhibition of DPP-IV activity are unclear. To test whether hindbrain DPP-IV inhibition suppresses blood glucose, feeding, and body weight gain, the effects of 4th intracerebroventricular (ICV) administration of the FDA-approved DPP-IV inhibitor sitagliptin were evaluated. Results indicate that hindbrain delivery of sitagliptin improves glycemic control in a GLP-1R-dependent manner, suggesting that this effect is due at least in part to increased endogenous brainstem GLP-1 activity after sitagliptin administration. Furthermore, 4th ICV injection of sitagliptin reduced 24h body weight gain and energy intake, with a selective suppression of high-fat diet, but not chow, intake. These data reveal a novel role for hindbrain GLP-1R activation in glycemic control and also demonstrate that DPP-IV inhibition in the caudal brainstem promotes negative energy balance.

  19. Sonochemical redox reactions of Pu(III) and Pu(IV) in aqueous nitric solutions.

    Virot, Matthieu; Venault, Laurent; Moisy, Philippe; Nikitenko, Sergey I

    2015-02-14

    The behavior of Pu(iv) and Pu(iii) was investigated in aqueous nitric solutions under ultrasound irradiation (Ar, 20 kHz). In the absence of anti-nitrous reagents, ultrasound has no effect on Pu(iv), while Pu(iii) can be rapidly oxidized to Pu(iv) due to the autocatalytic formation of HNO(2) induced by HNO(3) sonolysis. In the presence of anti-nitrous reagents (sulfamic acid or hydrazinium nitrate), Pu(iv) can be sonochemically reduced to Pu(iii). The reduction follows a first order reaction law and leads to a steady state where Pu(iv) and Pu(iii) coexist in solution. The reduction process is attributed to the sonochemical generation of H(2)O(2) in solution. The kinetics attributed to the reduction of Pu(iv) are however higher than those related to the formation of H(2)O(2) which, after several hypotheses, is explained by the sonochemical erosion of the titanium-based sonotrode. Titanium particles thereby generated can be solubilized under ultrasound and generate Ti(iii) as an intermediate species, a strong reducing agent able to react with Pu(iv).

  20. Plutonium(IV) sorption to montmorillonite in the presence of organic matter.

    Boggs, Mark A; Dai, Zurong; Kersting, Annie B; Zavarin, Mavrik

    2015-03-01

    The effect of altering the order of addition in a ternary system of plutonium(IV), organic matter (fulvic acid, humic acid and desferrioxamine B), and montmorillonite was investigated. A decrease in Pu(IV) sorption to montmorillonite in the presence of fulvic and humic acid relative to the binary Pu-montmorillonite system, is attributed to strong organic aqueous complex formation with aqueous Pu(IV). No dependence on the order of addition was observed. In contrast, in the system where Pu(IV) was equilibrated with desferrioxamine B (DFOB) prior to addition of montmorillonite, an increase in Pu(IV) sorption was observed relative to the binary system. When DFOB was equilibrated with montmorillonite prior to addition of Pu(IV), Pu(IV) sorption was equivalent to the binary system. X-ray diffraction and transmission electron microscopy revealed that DFOB accumulated in the interlayer of montmorillonite. The order of DFOB addition plays an important role in the observed sorption/desorption behavior of Pu. The irreversible nature of DFOB accumulation in the montmorillonite interlayer leads to an apparent dependence of Pu sorption on the order of addition in the ternary system. This work demonstrates that the order of addition will be relevant in ternary systems in which at least one component exhibits irreversible sorption behavior.

  1. Clinical characteristics of patients with Rutherford category IV, compared with V and VI

    Taketsugu Tsuchiya

    2015-07-01

    Full Text Available Objective: Patients categorized Rutherford category IV might have different characteristics compared with Rutherford category V and VI. Our study aims were to estimate the clinical differences between Rutherford category IV and Rutherford category V and VI, for those underwent endovascular therapy for isolated infrapopliteal disease, and also to find risk factors for endovascular therapy in Rutherford category IV. Methods: Based on the Japanese multi-center registry data, 1091 patients with 1332 limbs (Rutherford category IV: 226 patients with 315 limbs, Rutherford category V and VI: 865 patients with 1017 limbs were analyzed retrospectively. Results: Patients’ backgrounds and lesions’ characteristics had significant differences. Both freedom rate from major adverse limb event with perioperative death and amputation-free survival rate at 1 year were better in Rutherford category IV than Rutherford category V and VI (93.6% vs 78.3%, 87.7% vs 66.7% and those maintained to 3 years (p  3.0 mg/dL, chronic obstructive pulmonary disease, and coronary artery disease in Rutherford category IV. Conclusion: From the present results, Rutherford category IV should be recognized to have quite different backgrounds and better outcome from Rutherford category V and VI.

  2. Dithio- and Diselenophosphinate Thorium(IV) and Uranium(IV) Complexes: Molecular and Electronic Structures, Spectroscopy, and Transmetalation Reactivity.

    Behrle, Andrew C; Kerridge, Andrew; Walensky, Justin R

    2015-12-21

    We report a comparison of the molecular and electronic structures of dithio- and diselenophosphinate, (E2PR2)(1-) (E = S, Se; R = (i)Pr, (t)Bu), with thorium(IV) and uranium(IV) complexes. For the thorium dithiophosphinate complexes, reaction of ThCl4(DME)2 with 4 equiv of KS2PR2 (R = (i)Pr, (t)Bu) produced the homoleptic complexes, Th(S2P(i)Pr2)4 (1S-Th-(i)Pr) and Th(S2P(t)Bu2)4 (2S-Th-(t)Bu). The diselenophosphinate complexes were synthesized in a similar manner using KSe2PR2 to produce Th(Se2P(i)Pr2)4 (1Se-Th-(i)Pr) and Th(Se2P(t)Bu2)4 (2Se-Th-(t)Bu). U(S2P(i)Pr2)4, 1S-U-(i)Pr, could be made directly from UCl4 and 4 equiv of KS2P(i)Pr2. With (Se2P(i)Pr2)(1-), using UCl4 and 3 or 4 equiv of KSe2P(i)Pr2 yielded the monochloride product U(Se2P(i)Pr2)3Cl (3Se-U(iPr)-Cl), but using UI4(1,4-dioxane)2 produced the homoleptic U(Se2P(i)Pr2)4 (1Se-U-(i)Pr). Similarly, the reaction of UCl4 with 4 equiv of KS2P(t)Bu2 yielded U(S2P(t)Bu2)4 (2S-U-(t)Bu), whereas the reaction with KSe2P(t)Bu2 resulted in the formation of U(Se2P(t)Bu2)3Cl (4Se-U(tBu)-Cl). Using UI4(1,4-dioxane)2 and 4 equiv of KSe2P(t)Bu2 with UCl4 in acetonitrile yielded U(Se2P(t)Bu2)4 (2Se-U-(t)Bu). Transmetalation reactions were investigated with complex 2Se-U-(t)Bu and various CuX (X = Br, I) salts to yield U(Se2P(t)Bu2)3X (6Se-U(tBu)-Br and 7Se-U(tBu)-I) and 0.25 equiv of [Cu(Se2P(t)Bu2)]4 (8Se-Cu-(t)Bu). Additionally, 2Se-U-(t)Bu underwent transmetalation reactions with Hg2F2 and ZnCl2 to yield U(Se2P(t)Bu2)3F (6) and U(Se2P(t)Bu2)3Cl (4Se-U(tBu)-Cl), respectively. The molecular structures were analyzed using (1)H, (13)C, (31)P, and (77)Se NMR and IR spectroscopy and structurally characterized using X-ray crystallography. Using the QTAIM approach, the electronic structure of all homoleptic complexes was probed, showing slightly more covalent bonding character in actinide-selenium bonds over actinide-sulfur bonds.

  3. Multi-Electron Oxidation of Anthracene Derivatives by Nonheme Manganese(IV)-Oxo Complexes.

    Sharma, Namita; Jung, Jieun; Lee, Yong-Min; Seo, Mi Sook; Nam, Wonwoo; Fukuzumi, Shunichi

    2017-03-27

    Six-electron oxidation of anthracene to anthraquinone by a nonheme Mn(IV)-oxo complex, [(Bn-TPEN)MnIV(O)]2+, proceeds via the rate-determining electron transfer from anthracene to [(Bn-TPEN)MnIV(O)]2+, followed by subsequent fast oxidation reactions to give anthraquinone. The reduced Mn(II) complex ([(Bn-TPEN)MnII]2+) is oxidized by [(Bn-TPEN)MnIV(O)]2+ rapidly to produce the μ-oxo dimer ([(Bn-TPEN)MnIII-O-MnIII(Bn-TPEN)]4+). The oxygen atoms of the anthraquinone product were found to derive from the manganese-oxo species by the 18O labelling experiments. In the presence of Sc3+ ion, formation of anthracene radical cation was directly detected in electron transfer from anthracene to a Sc3+ ion-bound MnIV(O) com-plex, [(Bn-TPEN)MnIV(O)-(Sc(OTf)3)2]2+, followed by subsequent further oxidation to yield anthraquinone. When anthracene was replaced by 9,10-dimethylanthracene, elec-tron transfer from 9,10-dimethylanthracene to [(Bn-TPEN)MnIV(O)-(Sc(OTf)3)2]2+ occurred rapidly to produce stable 9,10-dimethylanthracene radical cation. The driving force dependence of the rate constants of electron transfer from anthracene derivatives to [(Bn-TPEN)MnIV(O)]2+ and [(Bn-TPEN)MnIV(O)-(Sc(OTf)3)2]2+ was well evaluated in light of the Marcus theory of electron transfer.

  4. Type IV collagen is a novel DEJ biomarker that is reduced by radiotherapy.

    McGuire, J D; Gorski, J P; Dusevich, V; Wang, Y; Walker, M P

    2014-10-01

    The dental basement membrane (BM) is composed of collagen types IV, VI, VII, and XVII, fibronectin, and laminin and plays an inductive role in epithelial-mesenchymal interactions during tooth development. The BM is degraded and removed during later-stage tooth morphogenesis; however, its original position defines the location of the dentin-enamel junction (DEJ) in mature teeth. We recently demonstrated that type VII collagen is a novel component of the inner enamel organic matrix layer contiguous with the DEJ. Since it is frequently co-expressed with and forms functional complexes with type VII collagen, we hypothesized that type IV collagen should also be localized to the DEJ in mature human teeth. To identify collagen IV, we first evaluated defect-free erupted teeth from various donors. To investigate a possible stabilizing role, we also evaluated extracted teeth exposed to high-dose radiotherapy--teeth that manifest post-radiotherapy DEJ instability. We now show that type IV collagen is a component within the morphological DEJ of posterior and anterior teeth from individuals aged 18 to 80 yr. Confocal microscopy revealed that immunostained type IV collagen was restricted to the 5- to 10-µm-wide optical DEJ, while collagenase treatment or previous in vivo tooth-level exposure to > 60 Gray irradiation severely reduced immunoreactivity. This assignment was confirmed by Western blotting with whole-tooth crown and enamel extracts. Without reduction, type IV collagen contained macromolecular α-chains of 225 and 250 kDa. Compositionally, our results identify type IV collagen as the first macromolecular biomarker of the morphological DEJ of mature teeth. Given its network structure and propensity to stabilize the dermal-epidermal junction, we propose that a collagen-IV-enriched DEJ may, in part, explain its well-known fracture toughness, crack propagation resistance, and stability. In contrast, loss of type IV collagen may represent a biochemical rationale for the DEJ

  5. An efficient strategy for heterologous expression and purification of active peptide hainantoxin-IV.

    Hui Zhang

    Full Text Available Hainantoxin-IV (HNTX-IV from the venom of the spider Selenocosmia hainana is a potent antagonist that specifically inhibits the tetrodotoxin-sensitive (TTX-S sodium channels. The toxin peptide consists of 35 amino acids and adopts a typical inhibitory cystine knot (ICK motif. To obtain adequate HNTX-IV peptides for further insight into the structure-activity relationships of the toxin, a novel strategy including cloning, expression and purification was developed in an E. coli expression system. For this purpose, a seamless restriction-free (RF cloning method was employed for the construction of an expression vector to avoid introducing unwanted sequences into the target gene. Furthermore, the solubility of recombinant HNTX-IV could be promoted efficiently by the combination of a glutathione S-transferase (GST tag and a small ubiquitin-related modifier (SUMO tag. Finally, an affinity-chromatography-free purification strategy was developed by cut-off dialysis tubing combined with trichloroacetic acid (TCA extraction. Further HPLC purification yielded recombinant, tag-free HNTX-IV with high yield and purity. The molecular weight of recombinant HNTX-IV (rHNTX-IV is identical to its theoretical value according to Matrix-Assisted Laser Desorption / Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS analysis. The recombinant toxin has similar activity (IC50 value of 120 nM on the tetrodotoxin-sensitive (TTX-S sodium channels in adult rat dorsal root ganglion (DRG neurons to native toxins. In the report, an efficient and cost-effective strategy for producing rHNTX-IV was developed, which paved the way for the further study of structure-activity relationships of rHNTX-IV and its pharmaceutical applications.

  6. Arrangement of type IV collagen on NH₂ and COOH functionalized surfaces.

    Coelho, Nuno Miranda; González-García, Cristina; Salmerón-Sánchez, Manuel; Altankov, George

    2011-12-01

    Apart from the paradigm that cell-biomaterials interaction depends on the adsorption of soluble adhesive proteins we anticipate that upon distinct conditions also other, less soluble ECM proteins such as collagens, associate with the biomaterials interface with consequences for cellular response that might be of significant bioengineering interest. Using atomic force microscopy (AFM) we seek to follow the nanoscale behavior of adsorbed type IV collagen (Col IV)--a unique multifunctional matrix protein involved in the organization of basement membranes (BMs) including vascular ones. We have previously shown that substratum wettability significantly affects Col IV adsorption pattern, and in turn alters endothelial cells interaction. Here we introduce two new model surfaces based on self-assembled monolayers (SAMs), a positively charged -NH(2) , and negatively charged -COOH surface, to learn more about their particular effect on Col IV behavior. AFM studies revealed distinct pattern of Col IV assembly onto the two SAMs resembling different aspects of network-like structure or aggregates (suggesting altered protein conformation). Moreover, the amount of adsorbed FITC-labeled Col IV was quantified and showed about twice more protein on NH(2) substrata. Human umbilical vein endothelial cells attached less efficiently to Col IV adsorbed on negatively charged COOH surface judged by altered cell spreading, focal adhesions formation, and actin cytoskeleton development. Immunofluorescence studies also revealed better Col IV recognition by both α(1) and α(2) integrins on positively charged NH(2) substrata resulting in higher phosphorylated focal adhesion kinase recruitment in the focal adhesion complexes. On COOH surface, no integrin clustering was observed. Taken altogether these results, point to the possibility that combined NH(2) and Col IV functionalization may support endothelization of cardiovascular implants.

  7. Formation of uranium(IV)-silica colloids at near-neutral pH

    Dreissig, Isabell; Weiss, Stephan; Hennig, Christoph; Bernhard, Gert; Zänker, Harald

    2011-01-01

    Evidence is provided by photon correlation spectroscopy, ultrafiltration and ultracentrifugation that uranium(IV) can form silicate-containing colloids of a size of ⩽20 nm. A concentration of up to 10 -3 M of colloid-borne U(IV) was observed. The particles are generated in near-neutral to slightly alkaline solutions containing background chemicals of geogenic nature (carbonate, silicate, sodium ions). They remain stable in aqueous suspension over years. Electrostatic repulsion due to a negative zeta potential in the near-neutral to alkaline pH range caused by the silicate stabilizes the U(IV) colloids. The isoelectric point of the nanoparticles is shifted toward lower pH values by the silicate. The mechanism of the colloidal stabilization can be regarded as "sequestration" by silicate, a phenomenon well known from heavy metal ions of high ion potential such as iron(III) or manganese(III,IV), but never reported for uranium(IV) so far. Extended X-ray absorption fine structure (EXAFS) spectroscopy showed that U-O-Si bonds, which increasingly replace the U-O-U bonds of the amorphous uranium(IV) oxyhydroxide with increasing silicate concentrations, make up the internal structure of the colloids. The next-neighbor coordination of U(IV) in the U(IV)-silica colloids is comparable with that of coffinite, USiO 4. The assessment of uranium behavior in the aquatic environment should take the possible existence of U(IV)-silica colloids into consideration. Their occurrence might influence uranium migration in anoxic waters.

  8. The effect of the Ti (IV-citrate complex on staphylococcus aureus growth and biofilm formation

    Gritsenko Viktor A.

    2015-01-01

    Full Text Available The primary objective of this study was to investigate the influence of the Ti (IV-citrate complex on growth dynamics and biofilm formation of S. aureus. Speciation analysis was performed in order to estimate the structure of the Ti complex existing in citrate solutions at near-physiological pH. It is estimated that the fully deprotonated tris(citratetitanate ion [Ti(C6H4O73]8- predominates in solution at pH 6.46-7.44, and that this is most probably the biologically active form of Ti(IV-citrate. In in vitro experiments, increasing concentrations of citric acid solutions (0.05, 0.005, 0.0005 M, served as positive controls, while the effects of respective concentrations of Ti(IV-citrate were examined. The obtained results indicate that citrate decreased S. aureus 48 growth at all studied concentrations, whereas S. aureus 44 growth was decreased only by high concentrations of citrate (0.05M. Incubation of S. aureus culture with Ti(IV-citrate significantly potentiated citrate-induced effects. Ti(IV-citrate significantly altered specific bacterial growth rate in a similar manner. The most significant growth reduction was observed at the initial period of bacterial growth. At the same time, the opposite effect was detected in investigations of the effect of citrate and Ti(IV-citrate on S. aureus biofilm formation. Citric acid suppressed S. aureus biofilm formation, whereas Ti(IV-citrate displayed a significant stimulatory effect. Our findings suggest that Ti(IV-citrate possesses a more pronounced biological effect than citrate. The proposed mechanism of this action is activation of complex transport into the cell and induction of oxidative stress. However, the exact mechanism of Ti(IV-citrate biological action on bacterial cultures remains unknown.

  9. Systematic investigation of thorium(IV)- and uranium(IV)-ligand bonding in dithiophosphonate, thioselenophosphinate, and diselenophosphonate complexes.

    Behrle, Andrew C; Barnes, Charles L; Kaltsoyannis, Nikolas; Walensky, Justin R

    2013-09-16

    Homoleptic soft-donor actinide complexes of the general form An[E2PROR']4 were synthesized from salt metathesis between ThCl4(DME)2 or UI4(1,4-dioxane)2 and M[E2PROR'], M = Na, K, to yield 2 (An = Th, E = S, R = 4-MeOC6H4, R' = Me), 3 (An = Th, E = S, R = 4-MeOC6H4, R' = (t)Bu), 4 (An = U, E = S, R = 4-MeOC6H4, R' = Me), 5 (An = Th, E = Se, R = C6H5, R' = Me), and 6 (An = U, E = Se, R = C6H5, R' = Me). In addition thorium and uranium thioselenophosphinate complexes 7 and 8 were produced from the reaction of ThCl4(DME)2 and UI4(1,4-dioxane)2 and Na[SSePPh2], respectively. All compounds were characterized using elemental analysis, (1)H and (31)P NMR, and IR spectroscopy, and the U(IV) compounds were also examined with UV-vis spectroscopy. The (77)Se NMR spectrum of 5 reveals the first reported resonance with a Th-Se bond. The solid-state structures of 2, 5, 7, and 8 were determined by X-ray crystallography. The actinide-ligand bonding was examined using density functional theory calculations in conjunction with quantum theory of atoms-in-molecules analysis and shows slightly increased covalency in actinide-selenium bonds than actinide-sulfur.

  10. Synthesis and Characterization of Tin(IV) Oxide Obtained by Chemical Vapor Deposition Method

    Nagirnyak, Svitlana V.; Lutz, Victoriya A.; Dontsova, Tatiana A.; Astrelin, Igor M.

    2016-07-01

    The effect of precursors on the characteristics of tin oxide obtained by chemical vapor deposition (CVD) method was investigated. The synthesis of nanosized tin(IV) oxide was carried out with the use of two different precursors: tin(II) oxalate obtained using tin chloride(II) and oxalic acid; tin(II) oxalate obtained using tin chloride(II); and ammonium oxalate. The synthesized tin(IV) oxide samples were studied by electron microscopy, X-ray diffraction and optical spectra. The lattice parameters of tin(IV) oxide samples were defined, the bandgap of samples were calculated.

  11. Modulation of C1-Inhibitor and Plasma Kallikrein Activities by Type IV Collagen

    Sriram Ravindran; Marc Schapira; Patston, Philip A.

    2012-01-01

    The contact system of coagulation can be activated when in contact with biomaterials. As collagen is being tested in novel biomaterials in this study, we have investigated how type IV collagen affects plasma kallikrein and C1-inhibitor. Firstly, we showed C1-inhibitor binds to type IV collagen with a Kd of 0.86 μM. The effects of type IV collagen on plasma kallikrein, factor XIIa, and β-factor XIIa activity and on C1-inhibitor function were determined. Factor XIIa rapidly lost activity in the...

  12. Dipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IV

    Bjelke, Jais R; Christensen, Jesper; Nielsen, Per F;

    2006-01-01

    of the two proteins can be expressed as active peptidases, which are 882 and 892 amino acids in length for dipeptidyl peptidase 8 and 9 respectively. We show further that the purified proteins are active dimers and that they show similar Michaelis-Menten kinetics and substrate specificity. Both cleave...... the peptide hormones glucagon-like peptide-1, glucagon-like peptide-2, neuropeptide Y and peptide YY with marked kinetic differences compared with dipeptidyl peptidase IV. Inhibition of dipeptidyl peptidases IV, 8 and 9 using the well-known dipeptidyl peptidase IV inhibitor valine pyrrolidide resulted...

  13. Titrimetric and Spectrophotometric Methods for the Assay of Ketotifen Using Cerium(IV) and Two Reagents

    Madihalli Srinivas Raghu; Kanakapura Basavaiah; Kudige Nagaraj Prashanth; Kanakapura Basavaiah Vinay

    2013-01-01

    One titrimetric and two spectrophotometric methods are described for the determination of ketotifen fumarate (KTF) in bulk drug and in tablets using cerium(IV) as the oxidimetric agent. In titrimetry (method A), the drug was treated with a measured excess of cerium(IV) in H2SO4 medium and after a standing time of 10 min, the surplus oxidant was determined by back titration with iron(II). The spectrophotometric procedures involve addition of a known excess of cerium(IV) to KTF in acid medium f...

  14. IV DSA in the diagnosis and follow-up of dissection of the thoracic aorta

    Hendrickx, P.; Luska, G.; Laas, J.; Haverich, A.

    1986-05-01

    Intravenous DSA was performed in 53 patients with suspected dissection of the thoracic aorta and in 13 patients following surgery for aortic dissection. In 36 patients, the suspected diagnosis could be excluded definitely and, in 14 cases out of 17, a dissection was correctly diagnosed. All 11 type B dissections were correctly diagnosed. Of six type A dissections, only three were adequately demonstrated by IV DSA. In type B dissections, IV DSA is reliable, but in type A dissection with massive aortic insufficiency or pericardial tamponade the findings are not reliable. In all 13 patients who had surgery for dissection, IV DSA proved suitable for showing the anastomosis and progress of the disease.

  15. [4-(Dimethylaminopyridine-κN1]trimethyl(thiocyanato-κNtin(IV

    Ezzatollah Najafi

    2012-06-01

    Full Text Available In the title monomeric trimethyltin(IV isothiocyanate–4,4-dimethylpyridine adduct, [Sn(CH33(NCS(C7H10N2], the SnIV atom shows a trans-C3SnN2 trigonal bipyramidal coordination. The SnIV atom lies out of the equatorial plane by 0.033 (4 Å in the direction of the donor N atom of the N-heterocycle. The crystal studied was a non-merohedral twin with a minor component of 48.8 (2%.

  16. Preparation, characterization, and antitumor activity of new ethylenediamine platinum(IV) complexes containing mixed carboxylate ligands.

    Khokhar, A R; Deng, Y; Kido, Y; Siddik, Z H

    1993-05-01

    A series of ethylenediamine platinum(IV) complexes of the type PtIV(en)XA2 and PtIV(en)X'2A2, where X = 1,1-cyclobutanedicarboxylato or malonato, X' = chloro, cyclobutanecarboxylato, cyclopentanecarboxylato, or cyclohexanecarboxylato, and A = acetato or trifluoroacetato were synthesized and characterized by elemental analysis, infrared, and NMR (13C and 195Pt) spectroscopic techniques. These compounds had good to excellent antitumor activity against murine leukemia L1210 cells. Complexes with axial trifluoroacetate groups were superior to those with acetate ligands. Those possessing both axial trifluoroacetate groups and monodentate bis-carboxylate ligands in the equatorial positions were the most active in the series investigated.

  17. Oxyhydroxy Silicate Colloids: A New Type of Waterborne Actinide(IV) Colloids

    Zänker, Harald; Weiss, Stephan; Hennig, Christoph; Brendler, Vinzenz; Ikeda‐Ohno, Atsushi

    2016-01-01

    Abstract At the near‐neutral and reducing aquatic conditions expected in undisturbed ore deposits or in closed nuclear waste repositories, the actinides Th, U, Np, and Pu are primarily tetravalent. These tetravalent actinides (AnIV) are sparingly soluble in aquatic systems and, hence, are often assumed to be immobile. However, AnIV could become mobile if they occur as colloids. This review focuses on a new type of AnIV colloids, oxyhydroxy silicate colloids. We herein discuss the chemical cha...

  18. The hydrolyzation of collagen by fucoidan oligosaccharide's complex with CeIV

    Xu, Jiachao; Gao, Xin; Zhang, Zhaohui; Li, Zhaojie; Huo, Lihua; Xue, Changhu

    2006-04-01

    Fucoidan is such a polysaccharide that its hydroxies are easy to combine with lanthanons ion (CeIV) to form complex. This work obtained the complexes of three fucoidan oligosaccharides with different molecular weights F1 (>5000), F2 (1000 5000) and F3 (fucoidan oligosaccharide F3 can form complex with more CeIV than F1 and F2. Hydrolyzing collagen with the complex was carried out to produce amino acid and peptides. All the three fucoidan oligosaccharide complexes with CeIV (F1, F2, F3) can catalyze by the artificial hydrolytic enzyme, and the activity of the complex of F3 is the highest.

  19. Analysis of Phoenix Anomalies and IV and V Findings Applied to the GRAIL Mission

    Larson, Steve

    2012-01-01

    Analysis of patterns in IV&V findings and their correlation with post-launch anomalies allowed GRAIL to make more efficient use of IV&V services . Fewer issues. . Higher fix rate. . Better communication. . Increased volume of potential issues vetted, at lower cost. . Hard to make predictions of post-launch performance based on IV&V findings . Phoenix made sound fix/use as-is decisions . Things that were fixed eliminated some problems, but hard to quantify. . Broad predictive success in one area, but inverse relationship in others.

  20. Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex

    Sakata, Kazuko; Woo, Newton H.; Martinowich, Keri; Greene, Joshua S.; Schloesser, Robert J.; Shen, Liya; Lu, Bai

    2009-01-01

    Transcription of Bdnf is controlled by multiple promoters, which drive expression of multiple transcripts encoding for the same protein. Promoter IV contributes significantly to activity-dependent brain-derived neurotrophic factor (BDNF) transcription. We have generated promoter IV mutant mice (BDNF-KIV) by inserting a GFP-STOP cassette within the Bdnf exon IV locus. This genetic manipulation results in disruption of promoter IV-mediated Bdnf expression. BDNF-KIV animals exhibited significant...

  1. Native pyroglutamation of huwentoxin-IV: a post-translational modification that increases the trapping ability to the sodium channel.

    Mingqiang Rong

    Full Text Available Huwentoxin-IV (HWTX-IV, a tetrodotoxin-sensitive (TTX-s sodium channel antagonist, is found in the venom of the Chinese spider Ornithoctonus huwena. A naturally modified HWTX-IV (mHWTX-IV, having a molecular mass 18 Da lower than HWTX-IV, has also been isolated from the venom of the same spider. By a combination of enzymatic fragmentation and MS/MS de novo sequencing, mHWTX-IV has been shown to have the same amino acid sequence as that of HWTX-IV, except that the N-terminal glutamic acid replaced by pyroglutamic acid. mHWTX-IV inhibited tetrodotoxin-sensitive voltage-gated sodium channels of dorsal root ganglion neurons with an IC50 nearly equal to native HWTX-IV. mHWTX-IV showed the same activation and inactivation kinetics seen for native HWTX-IV. In contrast with HWTX-IV, which dissociates at moderate voltage depolarization voltages (+50 mV, 180000 ms, mHWTX-IV inhibition of TTX-sensitive sodium channels is not reversed by strong depolarization voltages (+200 mV, 500 ms. Recovery of Nav1.7current was voltage-dependent and was induced by extreme depolarization in the presence of HWTX-IV, but no obvious current was elicited after application of mHWTX-IV. Our data indicate that the N-terminal modification of HWTX-IV gives the peptide toxin a greater ability to trap the voltage sensor in the sodium channel. Loss of a negative charge, caused by cyclization at the N-terminus, is a possible reason why the modified toxin binds much stronger. To our knowledge, this is the first report of a pyroglutamic acid residue in a spider toxin; this modification seems to increase the trapping ability of the voltage sensor in the sodium channel.

  2. Dioxobridged complexes of molybdenum (IV) and tungsten (IV) with N-alkylphenothiazines and their interactions with L-cysteine and L-histidine

    B Keshavan; Kempe Gowda

    2001-06-01

    Six new dioxobridged complexes of molybdenum (IV) and tungsten (IV) with N-alkylphenothiazines having the general formula M2O4(L)2(H2O)2 [where M = molybdenum or tungsten and L = N-alkylphenothiazines] have been synthesised. The complexes have been characterised on the basis of analytical, molar conductance, magnetic susceptibility, spectral data, TGA and DTA. The low magnetic moments for the complexes are due to spin-spin interaction or metal-metal bonding. The interactions of these complexes with some biologically important amino acids have been studied.

  3. Apolipoprotein A-IV inhibits AgRP/NPY neurons and activates POMC neurons in the arcuate nucleus

    Apolipoprotein A-IV (apoA-IV) in the brain potently suppresses food intake. However the mechanisms underlying its anorexigenic effects remain to be identified. We first examined the effects of apoA-IV on cellular activities in hypothalamic neurons that co-express agouti-related peptide (AgRP) and ne...

  4. 40 CFR 147.51 - State-administered program-Class I, III, IV, and V wells.

    2010-07-01

    ... PROGRAMS Alabama § 147.51 State-administered program—Class I, III, IV, and V wells. The UIC program for Class I, III, IV and V wells in the State of Alabama, except those on Indian lands, is the program... for Class I, III, IV, and V UIC Program,” September 21, 1982; (3) Letter from Alabama Chief...

  5. Venezuela-MEM/USA-DOE Fossil Energy Report IV-11: Supporting technology for enhanced oil recovery - EOR thermal processes

    Venezuela

    2000-04-06

    This report contains the results of efforts under the six tasks of the Tenth Amendment anti Extension of Annex IV, Enhanced Oil Recovery Thermal Processes of the Venezuela/USA Energy Agreement. This report is presented in sections (for each of the six Tasks) and each section contains one or more reports that were prepared to describe the results of the effort under each of the Tasks. A statement of each Task, taken from the Agreement Between Project Managers, is presented on the first page of each section. The Tasks are numbered 68 through 73. The first through tenth report on research performed under Annex IV Venezuela MEM/USA-DOE Fossil Energy Report Number IV-1, IV-2, IV-3, IV-4, IV-5, IV-6, IV-7, IV-8, IV-9, IV-10 contain the results of the first 67 Tasks. These reports are dated April 1983, August 1984, March 1986, July 1987, November 1988, December 1989, October 1991, February 1993, March 1995, and December 1997, respectively.

  6. INFLUENCE OF NATURAL AND SYNTHETIC ORGANIC LIGANDS ON THE STABILITY AND MOBILITY OF REDUCED TC(IV)

    Nathalie A. Wall; Baohua Gu

    2012-12-20

    The primary objectives were (1) to quantify the interactions of organic ligands with Tc(IV) through the generation of thermodynamic (complexation) and kinetic parameters needed to assess and predict the mobility of reduced Tc(IV) at DOE contaminated sites; and (2) to determine the impact of organic ligands on the mobility and fate of reduced Tc(IV) under field geochemical conditions.

  7. Temporal stability of the Dutch version of the Wechsler Memory Scale - Fourth Edition (WMS-IV-NL)

    Bouman, Z.; Hendriks, M.P.H.; Aldenkamp, A.P.; Kessels, R.P.C.

    2015-01-01

    Objective: The Wechsler Memory Scale - Fourth Edition (WMS-IV) is one of the most widely used memory batteries. We examined the test–retest reliability, practice effects, and standardized regression-based (SRB) change norms for the Dutch version of the WMS-IV (WMS-IV-NL) after both short and long re

  8. Palliative Care in Improving Quality of Life and Symptoms in Patients With Stage III-IV Pancreatic or Ovarian Cancer

    2014-12-18

    Recurrent Ovarian Epithelial Cancer; Recurrent Ovarian Germ Cell Tumor; Recurrent Pancreatic Cancer; Stage III Pancreatic Cancer; Stage IIIA Ovarian Epithelial Cancer; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIB Ovarian Epithelial Cancer; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIC Ovarian Epithelial Cancer; Stage IIIC Ovarian Germ Cell Tumor; Stage IV Ovarian Epithelial Cancer; Stage IV Ovarian Germ Cell Tumor; Stage IV Pancreatic Cancer

  9. Concurrent validity of the DSM-IV scales Affective Problems and Anxiety Problems of the Youth Self-Report

    van Lang, NDJ; Ferdinand, RF; Oldehinkel, AJ; Ormel, J; Verhulst, FC

    2005-01-01

    This study investigated the concurrent validity of the DSM-IV scales Anxiety Problems and Affective Problems of the Youth Self-Report (YSR) in a community sample of Dutch young adolescents aged 10-12 years. We first examined the extent to which the YSR/DSM-IV scales reflect symptoms of DSM-IV anxiet

  10. Kaubamaja Lastemaailm IV korrusel = Children's World on the fourth floor of Tallinn Department Store

    2015-01-01

    Lastemaailm Tallinna Kaumabaja IV korrusel Gonsiori tänav 2. Arhitektuuri Sihtkapitali äramärkimine 2012 visuaalselt atraktiivse ning kontseptuaalselt tervikliku laste- ja vanemasõbraliku fantaasiamaailma loomise eest. Sisearhitektid Janno Roos, Andres Labi, Liisa Põime (Ruumilabor)

  11. Inhibitory effect of collagen-derived tripeptides on dipeptidylpeptidase-IV activity.

    Hatanaka, Tadashi; Kawakami, Kayoko; Uraji, Misugi

    2014-12-01

    The collagen tripeptide fragments Gly-Ala-Hyp, Gly-Pro-Ala and Gly-Pro-Hyp were generated by hydrolyzing collagen from pig-skin, cattle-skin, fish-scales and chicken-feet, respectively, with Streptomyces collagenase. Collagenase treatment increased the concentration of tripeptides in the hydrolysates by 13-15% (w/w). Of the three peptides, Gly-Pro-Hyp was a true peptidic inhibitor of dipeptidylpeptidase-IV (DPP-IV), because DPP-IV could not hydrolyze the bond between Pro-Hyp. This tripeptide was a moderately competitive inhibitor (Ki=4.5 mM) of DPP-IV, and its level in the collagen hydrolysates could be greatly increased (4-9% [w/w]) using Streptomyces collagenase.

  12. 7S Fragment of Type IV Collagen as a Serum Marker of Canine Liver Fibrosis.

    Glińska-Suchocka, K; Orłowska, A; Kubiak, K; Spużak, J; Jankowski, M

    2016-09-01

    The aim of this study was to assess whether the serum levels of the 7S fragment of type IV collagen may aid in diagnosing liver fibrosis in dogs. The study was carried out on 20 dogs with liver disease. Serum levels of the 7S fragment of type IV collagen were measured in all dogs. The analysis showed that healthy dogs and dogs with type 1, 2 and 3 liver fibrosis had low serum concentrations of the 7S fragment of type IV collagen compared to dogs with type 4 liver fibrosis. The study revealed that the assessment of serum levels of the 7S fragment of type IV collagen is useful in the diagnosis of advanced liver fibrosis and cirrhosis.

  13. [Relationship between self-reported ADHD symptoms and WAIS-IV performance].

    Theiling, J; Petermann, F; Daseking, M

    2013-11-01

    This study has examined the relationship between cognitive functions and self-reported symptoms in ADHD adults. Cognitive functions were investigated with the Wechsler Adult Intelligence Scale-IV (WAIS-IV) in N=113 ADHD adults. The severity of self-reported symptoms was based on a screening questionnaire (ADHS-E). Results indicated only weak correlations between self-reported ADHD symptoms and WAIS-IV performance. The ADHS-E scale "Emotion & Affect" accounted for a small but significant variance on most WAIS-IV indices and turned out to be the most important variable to explain performance. The findings suggest that concurrent and discrepant information contribute to a differentiated examination on adult ADHD and that both objective performance diagnostics and self-reports complement each other within the diagnostic process.

  14. Narrative report: 1964: Lake Ilo National Wildlife Refuge & Easement Refuges - District IV

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Lake Ilo NWR and the District IV easement refuges outlines Refuge accomplishments during the 1964 calendar year. The report begins...

  15. Streptocollin, a type IV lanthipeptide produced by Streptomyces collinus Tü 365

    Iftime, Dumitrita; Jasyk, Martin; Kulik, Andreas

    2015-01-01

    Lanthipeptides are ribosomally synthesized and posttranslationally modified microbial secondary metabolites. Here, we report the identification and isolation of streptocollin from Streptomyces collinus Tü 365, a new member of the class IV lanthipeptides. Insertion of the constitutive ermE* promot...

  16. Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants

    Klausen, M.; Heydorn, Arne; Ragas, Paula Cornelia;

    2003-01-01

    Biofilm formation by Gfp-tagged Pseudomonas aeruginosa PAO1 wild type, flagella and type IV pili mutants in flow chambers irrigated with citrate minimal medium was characterized by the use of confocal laser scanning microscopy and comstat image analysis. Flagella and type IV pili were not necessary...... for P. aeruginosa initial attachment or biofilm formation, but the cell appendages had roles in biofilm development, as wild type, flagella and type IV pili mutants formed biofilms with different structures. Dynamics and selection during biofilm formation were investigated by tagging the wild type...... and flagella/type IV mutants with Yfp and Cfp and performing time-lapse confocal laser scanning microscopy in mixed colour biofilms. The initial microcolony formation occurred by clonal growth, after which wild-type P. aeruginosa bacteria spread over the substratum by means of twitching motility. The wild-type...

  17. DSM-IV Diagnoses and Obstructive Sleep Apnea in Children Before and 1 Year after Adenotonsillectomy

    Dillon, James E.; Blunden, Sarah; Ruzicka, Deborah L.; Guire, Kenneth E.; Champine, Donna; Weatherly, Robert A.; Hodges, Elise K.; Giordani, Bruno J.; Chervin, Ronald D.

    2007-01-01

    DSM-IV criteria-based psychiatric diagnoses done in children before and one year after adenotonsillectomy are assessed to record any improvement in behavior. It is found that surgery might be associated with reduced behavioral morbidity.

  18. A Chiral, Photoluminescent, and Spin-Canted {Cu(I)Re(IV)2}n Branched Chain.

    Martínez-Lillo, José; Armentano, Donatella; Fortea-Pérez, Francisco R; Stiriba, Salah-Eddine; De Munno, Giovanni; Lloret, Francesc; Julve, Miguel; Faus, Juan

    2015-05-18

    A new heteroleptic 1D Cu(I)-Re(IV) coordination polymer of the formula {Cu(I)Re(IV)Cl4(μ-Cl)(μ-pyz)[Re(IV)Cl4(μ-bpym)]}n·nMeNO2 (1; pyz = pyrazine, bpym = 2,2'-bipyrimidine) has been prepared through the Cu(I)-mediated self-assembly of two different Re(IV) metalloligands, namely, [ReCl5(pyz)](-) and [ReCl4(bpym)]. 1 consists of chiral branched chains with an overall rack-type architecture displaying photoemission and magnetic ordering. These results constitute a first step toward making new multifunctional magnetic materials based on mixed 3d-5d molecular systems.

  19. Narrative report: Calendar year 1966: Lake Ilo National Wildlife Refuge & Easement Refuges - District IV

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Lake Ilo NWR and the District IV easement refuges outlines Refuge accomplishments during the 1966 calendar year. The report begins...

  20. A core cross-linked polymeric micellar platium(IV) prodrug with enhanced anticancer efficiency.

    Hou, Jie; Shang, Jincai; Jiao, Chengbin; Jiang, Peiyue; Xiao, Huijie; Luo, Lan; Liu, Tongjun

    2013-07-01

    A core cross-linked polymeric micellar cisplatin(IV) conjugate prodrug is prepared by attaching the cisplatin(IV) to mPEG-b-PLL biodegradable copolymers to form micellar nanoparticles that can disintegrate to release the active anticancer agent cisplatin(II) in a mild reducing environment. Moreover, in vitro studies show that this cisplatin(IV) conjugate prodrug displays enhanced cytotoxicity against HepG2 cancer cells compared with cisplatin(II). Further studies demonstrate that the high cellular uptake and platinum-DNA adduct of this cisplatin(IV) conjugate prodrug can induce more cancer-cell apoptosis than cisplatin(II), which is responsible for its enhanced anticancer activity.