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Sample records for 2-18ffluoro-2-deoxy-d-glucose 18fdg stored

  1. F-18 FDG PET in Detecting Renal Cell Carcinoma

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    Ak, I.; Can, C. [Osmangazi Univ. Medical Faculty, Eskisehir (Turkey). Depts. of Nuclear Medicine and Urology

    2005-12-01

    Purpose: To assess the role of F-18 FDG imaging with a dual head coincidence mode gamma camera (Co-PET) in the detection of renal cell carcinoma (RCC) in patients with renal masses. Material and Methods: An F-18 FDG Co-PET study was performed in 19 patients (7 F, 12 M; mean age 58.15{+-}2.5 years, age range 45-79 years) with suspected primary renal tumors based on conventional imaging techniques, including computed tomography (CT) and ultrasonography (US) before nephrectomy or surgical resection of the mass. Results: Histologically documented RCC was present in 15 patients. Of the 19 patients with suspected primary renal tumors, F-18 FDG Co-PET was true-positive in 13, false-negative in 2, true-negative in 3, and false-positive in 1 patient. Twangiomyolipomas and one renal mass due to infarction and hemorrhage showed a true-negative Co-PET result. The patient with false-positive FDG Co-PET study was diagnosed as xantogranulomatous pyelonephritis. Overall sensitivity, specificity, and accuracy of FDG Co-PET for RCC were 86% (13/15), 75% (3/4), and 84% (16/19), respectively. Positive predictive value for RCC was 92% and negative predictive value 60%. Conclusion: These findings suggest that F-18 FDG Co-PET may have a role in the diagnostic evaluation of patients with RCC and primary staging of disease. Positive F-18 FDG study may be predictive of the presence of RCC. However, a negative study does not exclude the RCC.

  2. Quantification of Kryptofix2.2.2 in ~(18)FDG by HPLC

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    2-deoxy-2-[18F] fluoro-D-glucose (18FDG) is the most commonly used radiopharmaceutical for positron emission tomography (PET). Kryptofix2.2.2 (K-222) is used as a phase-transfer catalyst in the synthesis of 18FDG.Because of its toxicity

  3. A simple method for the quality control of [F-18]FDG

    DEFF Research Database (Denmark)

    Koziorowski, J.

    2010-01-01

    Most automated synthesis modules produce [F-18]FDG within half an hour, but the quality control involving up to three separate methods and three different analytical systems is time consuming. The use of HPLC, TLC, and GC for the quality control of [F-18]FDG is both time consuming and expensive...

  4. Dual time point 18FDG-PET/CT versus single time point 18FDG-PET/CT for the differential diagnosis of pulmonary nodules - A meta-analysis

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    Zhang, Li; Wang, Yinzhong [The First Clinical Medical School of Lanzhou Univ., Lanzhou, Gansu (China); Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou Univ., Lanzhou, Gansu (China); Lei, Junqiang; Tian, Jinhui; Zhai, Yanan [The First Clinical Medical School of Lanzhou Univ., Lanzhou, Gansu (China); Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou Univ., Lanzhou, Gansu (China); The First Hospital of Lanzhou Univ., Lanzhou, Gansu (China)

    2013-09-15

    Background: Lung cancer is one of the most common cancer types in the world. An accurate diagnosis of lung cancer is crucial for early treatment and management. Purpose: To perform a comprehensive meta-analysis to evaluate the diagnostic performance of dual time point 18F-fluorodexyglucose position emission tomography/computed tomography (FDG-PET/CT) and single time point 18FDG-PET/CT in the diagnosis of pulmonary nodules. Material and Methods: PubMed (1966-2011.11), EMBASE (1974-2011.11), Web of Science (1972-2011.11), Cochrane Library (-2011.11), and four Chinese databases; CBM (1978-2011.11), CNKI (1994-2011.11), VIP (1989-2011.11), and Wanfang Database (1994-2011.11) were searched. Summary sensitivity, summary specificity, summary diagnostic odds ratios (DOR), and summary positive likelihood ratios (LR+) and negative likelihood ratios (LR-) were obtained using Meta-Disc software. Summary receiver-operating characteristic (SROC) curves were used to evaluate the diagnostic performance of dual time point 18FDG-PET/CT and single time point 18FDG-PET/CT. Results: The inclusion criteria were fulfilled by eight articles, with a total of 415 patients and 430 pulmonary nodules. Compared with the gold standard (pathology or clinical follow-up), the summary sensitivity of dual time point 18FDG-PET/CT was 79% (95%CI, 74.0 - 84.0%), and its summary specificity was 73% (95%CI, 65.0-79.0%); the summary LR+ was 2.61 (95%CI, 1.96-3.47), and the summary LR- was 0.29 (95%CI, 0.21 - 0.41); the summary DOR was 10.25 (95%CI, 5.79 - 18.14), and the area under the SROC curve (AUC) was 0.8244. The summary sensitivity for single time point 18FDG-PET/CT was 77% (95%CI, 71.9 - 82.3%), and its summary specificity was 59% (95%CI, 50.6 - 66.2%); the summary LR+ was 1.97 (95%CI, 1.32 - 2.93), and the summary LR- was 0.37 (95%CI, 0.29 - 0.49); the summary DOR was 6.39 (95%CI, 3.39 - 12.05), and the AUC was 0.8220. Conclusion: The results indicate that dual time point 18FDG-PET/CT and single

  5. A clinical positron emission tomography facility. 2-{sup 18}FDG studies: Development and results

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    Ohlsson, Tomas

    1996-10-01

    Two different types of accelerators have been used for production of ({sup 18}F)fluoride, and the isotope produced has been used for radiolabelling of 2-fluoro-2-deoxy-D-glucose (2-{sup 18}FDG). A rotating PET scanner, based on two scintillation camera heads, has been developed and used for human 2-{sup 18}FDG studies. The suitability of an energy window in the Compton region for imaging 511 keV photons in scintillation camera systems has been evaluated. A new simplified method for normalizing clinical 2-{sup 18}FDG results has been developed and validated, using erythrocytes as a reference tissue, requiring only one blood sample in the middle of the PET scan to calculate the integrated 2-{sup 18}FDG input function with an accuracy better than 8 percent. An investigation using 2-{sup 18}FDG PET to monitor the effect of therapy in advanced head and neck cancer patients has been performed. We found that low initial metabolic rate of glucose (MRG) predicted a complete local response. The second PET examination gave no further information for this group. In the group of primary tumours and lymph node metastases representing a combination of high initial MRG and small decrease in MRG at he second PET examination, the outcome was unfavourable. An accurate normalization of 2-{sup 18}FDG uptake was essential to evaluate the results of this study. 239 refs, 10 tabs.

  6. The Clinical Utility of Rectal Gas Distension F-18 FDG PET/CT

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    Kim, Jin Suk; Lim, Seok Tae; Jeong, Young Jin; Kim, Dong Wook; Jeong, Hwan Jeong; Sohn, Myung Hee [Chonbuk National University Medical School and Hospital, Jeonju (Korea, Republic of)

    2009-12-15

    The aim of this study was to evaluate the clinical value of rectal gas distension F-18 FDG PET/CT imaging for the differentiation of the rectal focal uptake lesions. Twenty four patients (M:F=11:13, Age 62.8{+-}12.4 years) underwent rectal gas distension F-18 FDG PET/CT, prospectively: initial image at 50-60 min after the intravenous injection of F-18 FDG and rectal distension image after the infusion of air through the anus. Focally increased uptake lesions on initial images but disappeared on rectal distension images defined a physiological uptake. For the differential evaluation of persistent focal uptake lesions on rectal distension images, colonoscopy and histopathologic examination were performed. Among the 24 patients, 27 lesions of focal rectal uptake were detected on initial images of F-18 FDG PET/CT. Of these, 7 lesions were able to judge with physiological uptake because the focal increased uptake disappeared from rectal distension image. Remaining 3 lesions were non-rectal lesions (2 lesions: rectovesical space, 1 lesion: uterine myoma). Among 17 lesions which was showed persistent increased uptake in rectal distension image, 15 lesions were confirmed as the malignant tumor (SUVmax=15.9{+-}6.8) and 2 lesions were confirmed as the benign lesions including adenoma and inflammatory disease. The rectal distension F-18 FDG PET/CT imaging could be an important noninvasive method for the differentiation of malignant and benign focal rectal uptake lesions including physiologic uptake.

  7. A Case of Acute Q Fever Hepatitis Diagnosed by F-18 FDG PET/CT

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    Beak, Sora [Hallym Univ. College of Medicine, Seoul (Korea, Republic of); Oh, Minyoung; Lee, Sand-Oh; Yu, Eunsil; Ryu Jin-Sook [Univ. of Ulsan College of Medicine, Seoul (Korea, Republic of)

    2012-06-15

    A 53-year-old man with fever of unknown origin underwent F-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) as a workup for a fever of unknown origin. On presentation, he complained of fever, chills, and myalgia. The F-18 FDG PET/CT scan showed diffusely increased uptake of the liver with mild hepatomegaly. A liver biopsy then revealed fibrin-ring granulomas typically seen in Q fever. The patient was later serologically diagnosed as having acute Q fever as the titers for C. IgM and IgG were 64:1 and -16:1, respectively. He recovered completely following administration of doxycycline. This indicates that F-18 FDG PET/CT may be helpful for identifying hepatic involvement in Q fever as a cause of fever of unknown origin.

  8. [Technical limits of PET/CT with 18FDG in prostate cancer].

    Science.gov (United States)

    von Mallek, D; Backhaus, B; Müller, S C; Matthies, A; Palmedo, H; Jaeger, U; Biersack, H-J; Reinhardt, M

    2006-05-01

    There is increasing evidence that (18)FDG-PET is not useful for the imaging of primary prostate cancer. The aim of this examination was to prove whether or not these poor results are due to technical deficiencies of the examination method like older image reconstruction techniques, extensive (18)FDG-tracer activity in the bladder or improper contrast staining of the rectum. We examined three patients with primary prostate cancer using a modern combined PET/CT system, continuous irrigation of the bladder and an air-inflated rectal balloon catheter. PET/CT images show an exact depiction of both the prostate and all surrounding anatomic structures but no enhanced uptake of radiotracer in the tumour. Therefore, the mentioned poor results of (18)FDG-PET seem not to be due to technical deficiencies.

  9. Factors Associated with Diffusely Increased Splenic F-18 FDG Uptake in Patients with Cholangiocarcinoma

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    Kim, Keunyoung; Kim, Seongjang; Kim, Injoo; Kim, Dong Uk; Kim, Heeyoung; Kim, Sojung; Ahn, Sang Hyun [Pusan National Univ. Hospital, Busan (Korea, Republic of)

    2014-06-15

    Although diffuse splenic {sup 18}F-fluorodeoxyglucose (F-18 FDG) uptake exceeding hepatic activity, is considered abnormal, its clinical significance is rarely discussed in the literature. The aim of this study was to determine the contributing factors causing diffusely increased splenic FDG uptake in patients with cholangiocarcinoma. From January 2010 to March 2013, 140 patients (84 men, 56 women) were enrolled in this study. All patients had been diagnosed with cholangiocarcinoma and underwent F-18 FDG positron emission tomography/computed tomography (PET/CT) for the pretreatment staging work up. Clinical records were reviewed retrospectively. Various hematological parameters, C-reactive protein (CRP) level, CEA, CA19-9, pancreatic enzymes and liver function tests were conducted within 2 days after the F-18 FDG PET/CT study. Diffuse splenic uptake was observed in 23 patients (16.4%). Of those, 19 patients (82.6%) underwent endoscopic retrograde cholangiopancreastography (ERCP) 7 days before F-18 FDG PET/CT. The CRP level (p <0.001) and white blood cell count (p =0.023) were significantly higher in the group of patients with diffuse splenic FDG uptake. The hemoglobin (p <0.001) and the hematocrit (p <0.001) were significantly lower in patients with diffuse splenic FDG uptake. Pancreatic enzymes, liver function test results, and tumor markers were not significantly different between the patients who did or did not have diffusely increased splenic FDG uptake. The significant factors for diffuse splenic F-18 FDG uptake exceeding hepatic F-18 FDG uptake on multivariate analysis included: performing ERCP before F-18 FDG PET-CT (odds ratio [OR], 77.510; 95% CI, 7.624-132.105), and the presence of leukocytosis (OR, 12.436; 95% CI, 2.438-63.445) or anemia (OR, 1.211; 95% CI, 1.051-1.871). In conclusion, our study demonstrated that concurrent inflammation could be associated with diffusely increased splenic FDG uptake. We suggest that performing ERCP before F-18 FDG PET

  10. Chorea in systemic lupus erythematosus: evidence for bilateral putaminal hypermetabolism on F-18 FDG PET

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    Seo, Wook Jang; Chung, Son Mi; Koh, Su Jin; Lee, Chang Keun; Yoo, Bin; Moon, Hee Bom [College of Medicine, Ulsan Univ., Seoul (Korea, Republic of); Kim, Jae Seung; Im, Joo Hyuk [Asan Medical Center, Seoul (Korea, Republic of)

    2003-10-01

    We describe a 54-year-old woman with systemic lupus erythematosus (SLE) who suddenly presented with chorea and had positive antiphospholipid antibodies. F-18 FDG PET showed abnormally increased glucose metabolism in bilateral putamen and primary motor cotex. Tc-99m ECD SPECT also showed abnormally increased regional cerebral blood flow in bilateral putamen. She was treated with corticosteroid and aspirin after which the symptoms improved. Four months later, follow up F-18 FDG PET showed improvement with resolution of hypermetabolism in bilateral putamen. This case suggests that striatal hypermetabolism is associated with chorea in SLE.

  11. F-18 FDG PET Images of the Cervix at Various Time Points after the Loop Electrosurgical Excision Procedure

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    Jeong, Shin Young [Kyungpook National University Medical School, Daegu (Korea, Republic of); Min, Jung Joon [Chonnam National University Medical School, Gwangju (Korea, Republic of)

    2010-04-15

    F-18 FDG PET is useful for monitoring residual or recurrent tumors after surgical resection. We describe five F-18 FDG PET images of three patients who had cervical carcinoma and then underwent a loop electro surgical excision procedure (LEEP). Two of the images were taken within 15 days and three at least 2 months after LEEP. The earlier F-18 FDG PET images revealed linear hypermetabolic lesions in the cervix that were produced by inflammation. This was confirmed by pathological analysis. The later F-18 FDG PET images did not reveal any remarkable hypermetabolism in the cervix without any treatment. These observations suggest that, to determine the response to LEEP therapy, F-18 FDG PET should not be performed within 15 days of the procedure.

  12. Hepatosplenic Cat-Scratch Disease in Children and the Positive Contribution of F-18-FDG Imaging

    NARCIS (Netherlands)

    Kraft, Karianne E.; Doedens, Rienus A.; Slart, Riemer H. J. A.

    2015-01-01

    Two patients were referred to our hospital because of suspected malignancy. In patient 1, a 4-year-old boy, a F-18-FDG PET scan showed an enlarged liver with multiple FDG-positive nodular lesions. In patient 2, a 16-year-old boy, a FDG PET-(low-dose) CT showed an enlarged liver and spleen with multi

  13. [F-18] FDG-PET/CT parameters as predictors of outcome in inoperable NSCLC patients

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    Nappi Antonio

    2015-12-01

    Full Text Available Background. We evaluated the prognostic significance of standardized uptake value (SUVmax, metabolic tumour volume (MTV, and total lesion glycolysis (TLG in [F-18] FDG PET/CT findings in patients with inoperable non-small-cell lung cancer (NSCLC.

  14. Influence of radiation on endotoxin test using the PTSTM for 18-FDG radiopharmaceutical

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    Santos-Oliveira, Ralph, E-mail: roliveira@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Div. de Radiofarmacia

    2010-07-15

    F-18 FDG (2-[18-F] fluoro-2-deoxy-D-glucose) is the most frequently used radiopharmaceutical for PET and PET CT imaging exams. The FDA recently approved the use of the PTS{sup TM} (Portable Test System) as an alternative to the standard test proposed by the United States Pharmacopeia using the LAL (Limulus Amebocyte Lysates), that takes longer to perform (about 1h) than the PTS{sup TM} (15 min). Recent studies have demonstrated that radiation could interfere with the PTS{sup TM} test. In order to study the effects of radiation on the PTS{sup TM} test and/or equipment, 27 batches of F-18 FDG produced in the Nuclear Engineering Institute were analyzed. The results showed that no direct correlation with radiation was found in any of the cases. (author)

  15. Cerebral Toxoplasmosis in a Patient with AIDS on F-18 FDG PET/CT

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    Kim, Hae Won; Won, Kyung Sook; Choi, Byung Wook; Zeon, Seok Kil [Keimyung University School of Medicine, Daegu (Korea, Republic of)

    2010-04-15

    The distinction between primary central nervous system (CNS) lymphoma and nonmalignant lesions due to opportunistic infections, in particular cerebral toxoplasmosis, is important because of the different treatments involved. A 32-year-old patient with AIDS was hospitalized for intermittent headaches. Brain magnetic resonance imaging (MRI) showed a small well-enhanced nodular lesion in the right frontal lobe. A fluorine-18 fluorodeoxyglucose (F-18 FDG) position emission tomography (PET)/ computed tomography (CT) scan showed moderate FDG uptake in the nodular lesion of the right frontal lobe. We present a case of cerebral toxoplasmosis in a patient with acquired immunodeficiency syndrome (AIDS) and the usefulness of F-18 FDG PET/CT in the differential diagnosis of the cerebral toxoplasmosis will be discussed.

  16. F18-FDG PET/CT Scanning in Angiosarcoma: Report of Two Cases

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    Emel TOKMAK

    2011-08-01

    Full Text Available Angiosarcomas are uncommon tumors and constitute less than 5% of all soft tissue sarcomas. They are aggressive tumors with poor prognosis, therefore, it is quite important to determine disease extension and detect local recurrence and/or distant metastases for appropriate therapy management. In this paper, we aimed to demonstrate the potential role of 1F18-FDG PET/CT imaging by reporting two cases with angiosarcoma (MIRT 2011;20:63-66

  17. Medial thalamic 18-FDG uptake following inescapable shock correlates with subsequent learned helpless behavior

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    Mirrione,M.M.; Mirrione, M.M.; Schulz, D.; Dewey, S.L.; Henn, F.A.

    2009-12-06

    The learned helplessness paradigm has been repeatedly shown to correlate with neurobiological aspects of depression in humans. In this model, rodents are exposed inescapable foot-shock in order to reveal susceptibility to escape deficit, defined as 'learned helplessness' (LH). Few methods are available to probe the neurobiological aspects underlying the differences in susceptibility in the living animal, thus far being limited to studies examining regional neurochemical changes with microdialysis. With the widespread implementation of small animal neuroimaging methods, including positron emission tomography (PET), it is now possible to explore the living brain on a systems level to define regional changes that may correlate with vulnerability to stress. In this study, 12 wild type Sprague-Dawley rats were exposed to 40 minutes of inescapable foot-shock followed by metabolic imaging using 2-deoxy-2[{sup 18}F]fluoro-D-glucose (18-FDG) 1 hour later. The escape test was performed on these rats 48 hours later (to accommodate radiotracer decay), where they were given the opportunity to press a lever to shut off the shock. A region of interest (ROI) analysis was used to investigate potential correlations (Pearson Regression Coefficients) between regional 18-FDG uptake following inescapable shock and subsequent learned helpless behavior (time to finish the test; number of successful lever presses within 20 seconds of shock onset). ROI analysis revealed a significant positive correlation between time to finish and 18-FDG uptake, and a negative correlation between lever presses and uptake, in the medial thalamic area (p=0.033, p=0.036). This ROI included the paraventricular thalamus, mediodorsal thalamus, and the habenula. In an effort to account for possible spillover artifact, the posterior thalamic area (including ventral medial and lateral portions) was also evaluated but did not reveal significant correlations (p=0.870, p=0.897). No other significant

  18. Pelvic congestion syndrome initially detected by contrast enhanced F 18 FDG PET/CT

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    Kim, Dae Weung; Kim, Myoung Hyoung; Kim, Woo Hyoung; Kim, Chang Guhn [Wonkwang Univ. School of Medicine, Iksan (Korea, Republic of)

    2012-03-15

    Pelvic congestion syndrome (PCS) is said to occur as a result of retrograde flow in an incompetent ovarian vein. Ovarian vein incompetence is seen in approximately 10% of women, and up to 60% with this abnormality can develop PCS. The etiology of PCS is poorly understood and is likely to be multifactorial. Absence of ovarian vein valves is an important factor in its development. The causes of ovarian varicoceles are multifactorial, involving both mechanical and hormonal factors. Dilatation of the ovarian veins can result in vascular incompetence and retrograde blood flow. On either CT or magnetic resonance (MR) imaging studies, pelvic varices in PCS appear as dilated, tortuous, enhancing tubular structures near the ovaries and uterus. In addition, the extension of varices to the broad ligament and paravaginal venous plexus can be appreciated. With CT, the tubular nature of these structures and the pattern of enhancement after intravenous contrast medium administration distinguish them from lymphadenopathy or adnexal masses. Unlike such masses, pelvic varices appear isodense with other veins after contrast enhancement. Contrast enhanced CT data as part of the combined PET/CT examination provide additional information when compared with non enhanced PET/CT. Because CT data supply the anatomic background for PET, the most important benefit relates to more precise anatomic localization of pathology by differentiation of the lesion from its surrounding structures. By supporting lesion detection and characterization, CT contrast agents can be of additional value in F 18 FDG non avid disease. As in the presented case, careful review of CT images in contrast enhanced PET/CT enables the detection of F 18 FDG non avid disease such as PCS. As contrast enhanced F 18 FDG PET/CT had been performed frequently, being familiar with the findings of PCS on the contrast enhanced CT images would have been helpful for the nuclear medicine physicians.

  19. F-18 FDG PET/CT in Bilateral Diffuse Pulmonary Lymphangitic Carcinomatosis

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    Senthil, Raja; Parghane, Rahul; Kashyap, Raghava; Bhattacharya, Anish; Mittal, Bhagwant Rai [Postgraduate Institute of Medical Education and Resaarch, Chandigarh (India)

    2012-06-15

    A 51-year-old female patient, who had undergone left-sided modified radical mastectomy for left breast carcinoma 4 years ago, presented with dyspnea of 4 months duration F-18 FDG PET/CT of this patient showed diffusely in-creased FDG uptake in the bilateral lung fields along the thickened bronchovascular bundles. SUVmax of lymphangitic lung was 5.2. The standardized uptake ratio (SUR) of mediastinal blood pool to lymphangitic lung was 0.44. High resolution computed tomography (HRCT) of the same patient showed thickening of interlobular septa and bronchovaseular bundles, with preservation of normal parenchymal architecture. Multiple intrapulmonary nodules and bilateral hilar lymphadenopathy with pulmonary lymphangitic carcinomatosis (PLC). The lungs are the second most common sites for metastases after lymph nodes. These metastases are usually nodular on radiologic images. PLC with interstitial involvement constitutes only 7% of pulmonary metastastases. The most common primary sites, in order of frequency, are adenocarcinoma of the lung, breast, stomach, colon, and prostrate. HRCT has been the modality of choice in the radiologic diagnosis of PLC. Only a few studies have de-scribed the F-18 FDG PET/CT findings in pulmonary lymphangitic carcinomatosis. These studies have shown diffusely increased FDG uptake corresponding to the typical changes in the CT as the most common finding. One study has reported that F-18 FDG PET/CT is 100% specific and 86% sensitive in diagnosing PLC by subjective analysis. The mean SUV in the region of pulmonary lymphangitic lung was 1.26{+-}0.45 and that of blood pool to normal lung was 3.78{+-}1.37.

  20. 18-FDG PET/CT assessment of basal cell carcinoma with vismodegib.

    Science.gov (United States)

    Thacker, Curtis A; Weiss, Glen J; Tibes, Raoul; Blaydorn, Lisa; Downhour, Molly; White, Erica; Baldwin, Jason; Hoff, Daniel D; Korn, Ronald L

    2012-10-01

    The use of 18-fluorodeoxyglucose (FDG) positron emission tomography with computed tomography (PET/CT) in subjects with advanced basal cell carcinoma (BCC) has not been fully explored due to the rarity of disease presentation. This study evaluated PET/CTs from subjects with advanced BCC participating in a phase I dose-escalation clinical trial of vismodegib. Fourteen subjects with BCC were imaged with 18-FDG PET/CT for lesion identification and response categorizing (European Organisation for Research and Treatment for Cancer [EORTC] and PET response criteria in solid tumors [PERCIST] 1.0). Several parameters including metabolic activity of target lesions, site of disease presentation and spread, treatment response, and prognostic significance of metabolic activity following therapy were evaluated. All subjects exhibited at least one hypermetabolic lesion. Most subjects had only four organ systems involved at study enrollment: skin-muscle (93%), lung (57%), lymph nodes (29%), and bone (21%). SUVmax measured across all lesions decreased (median 33%, SD ± 45%) following therapy with metabolic activity normalizing or disappearing in 42% of lesions. No significant difference was observed between EORTC and PERCIST 1.0. Subjects that demonstrated at least a 33% reduction in SUVmax from baseline had a significantly longer progression-free survival (PFS) (median 17 months, 95% confidence interval [CI] ±4 months vs. 9 months, 95% CI ±5 months, P = 0.038) and overall survival (OS) (median 24 months, 95% CI ±4 months vs. 17 months, 95% CI ±13 months, P = 0.019). BCC lesions are hypermetabolic on 18-FDG PET/CT. A decrease in SUVmax was associated with improved PFS and OS. These results further support the incorporation of 18-FDG PET/CT scans in advanced BCC management.

  1. F-18-FDG-PET for differential diagnosis of pleural processes; F-18-FDG-PET zur Primaerdiagnostik und Dignitaetsbeurteilung pleuraler Prozesse

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    Buchmann, I.; Guhlmann, C.A.; Schirrmeister, H.; Kotzerke, J.; Buck, A.; Reske, S.N. [Ulm Univ. (Germany). Abt. Nuklearmedizin; Elsner, K. [Ulm Univ. (DE). Abt. Radiologie 2 (Strahlentherapie); Gfroerer, W. [Universitaetsklinik Ulm (Germany). Abt. fuer Allgemeinchirurgie

    1999-07-01

    Purpose: Positron emission tomography (PET) with 18-fluorodeoxyglucose (FDG) has been shown to be accurate for differentiating benign from malignant pulmonary lesions. Therefore, we evaluated the capability of FDG-PET in the characterisation of pleural lesions. Patients and methods: PET was performed in thirteen patients with pleural or intrapulmonal tumors (three with additional pleural effusion) and in three patients with aetiologically unclear pleural effusion demonstrated by CT. In all cases the diagnosis was confirmed histologically. The PET-imaging was carried out in fasted patients 50 minutes after injection of 400-670 MBq F-18-FDG without attenuation correction. Results: Twelve patients were found to have pleural or pulmonal malignomas (9 pleural mesotheliomas, 3 bronchogenic adenocarcinoma with carcinomatous pleurisy). Four patients had benign pleural changes (1 fibroma, 1 tuberculous pleurisy, 1 pleural fibrosis, 1 empyema). With FDG-PET, all 12 pleural or intrapulmonal malignomas had high FDG-uptake and were classified correctly. Due to very low or virtually deficient FDG-uptake, four histologically benign lesions were correctly interpreted as nonmalignant. Conclusion: These preliminary results suggest that FDG-PET is accurate in detecting malignant pleural tumors. (orig.) [German] Ziel: Zahlreiche Studien belegen die hohe Treffsicherheit der Positronen-Emissions-Tomographie (PET) mit 2-[F-18]-Fluoro-2-desoxy-D-Glukose (FDG) bei der Dignitaetsbeurteilung nicht-verkalkter Lungenrundherde. Ziel dieser Untersuchung war die Evaluation der Wertigkeit der FDG-PET in der Primaerdiagnostik und Dignitaetsbeurteilung pleuraler Veraenderungen. Patienten/Methode: Dreizehn Patienten mit computertomographisch bekannten pleuralen Raumforderungen, von denen drei zusaetzlich einen Pleuraerguss aufwiesen, sowie drei Patienten mit aetiologisch unklarem Pleuraerguss wurden einer FDG-PET unterzogen. Die PET wurde 50 min nach i.v. Injektion von 400-670 MBq F-18-FDG in

  2. Myocardial Fibrosis in Hypertrophic Cardiomyopathy Demonstrated by Integrated Cardiac F-18 FDG PET/MR

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    Kong, Eunjung; Lee, Sanghee; Cho, Ihnho [Yeungnam Univ., Daegu (Korea, Republic of)

    2013-09-15

    Hypertrophic cardiomyopathy (HCM) is a common condition defined as a diffuse or segmental left ventricular (LV) hypertrophy with a nondilated and hyperdynamic chamber as well as cardiac arrhythmias. Cardiac MR (CMR) imaging is a key modality for evaluation of HCM. In addition to the assessment of LV wall thickness, LV function and aortic flow, CMR is capable of estimation of late gadolinium enhancement (LGE) in affected myocardium which has been shown to have a direct correlation with incidence and severity of arrhythmias in HCM. In patients with HCM, LGE on CMR is presumed to represent intramyocardial fibrosis. Meanwhile, F-18 FDG myocardial PET has been sporadically studied in HCM, mostly for evaluation of the metabolic status of a hypertrophic myocardial segment, especially after interventions or to demonstrate partial myocardial fibrosis. We presented here the case of a 25-year-old male patient referred for simultaneous F-18 FDG cardiac PET/MR for the evaluation of septal hypertrophy. The PET/MR revealed myocardial fibrosis in the septum associated with FDG-defect and LGE.

  3. F-18 FDG PET/CT Findings of a Patient with Takayasu Arteritis Before and After Therapy

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    Sait Sağer

    2012-04-01

    Full Text Available Vasculitis is defined as inflammation and necrosis with leukocytic infiltration of the blood vessel wall. Takayasu arteritis is a chronic inflammatory arteritis that primarily involves the aorta and its main branches. A 64-year-old female patient with a 2-month history of fever of unknown origin was presented to our clinic for F-18 FDG PET/CT imaging. Baseline PET/CT images demonstrated intense F-18 FDG uptake in the aorta, bilateral subclavian and brachiocephalic arteries consistent with Takayasu arteritis. After 2 months of immunosuppressive therapy, she was asymptomatic and follow-up FDG PET/CT scan showed almost complete disappearance of large vessels’ F-18 FDG uptake. FDG PET/CT is a sensitive technique for assessing presence of large-vessel vasculitis such as Takayasu arteritis, extent of large-vessel inflammation and disease activity after therapy. (MIRT 2012;21:32-34

  4. Imaging of large vessel vasculitis with {sup 18}FDG PET: illusion or reality? A critical review of the literature data

    Energy Technology Data Exchange (ETDEWEB)

    Belhocine, Tarik; Vandevivere, Johan [Department of Nuclear Medicine, A.Z. Middelheim Hospital, 2020, Antwerp (Belgium); Blockmans, Daniel [Department of Internal Medicine, Gasthuisberg University Hospital, Leuven (Belgium); Hustinx, Roland [Department of Nuclear Medicine, University Hospital of Liege, Liege (Belgium); Mortelmans, Luc [Department of Nuclear Medicine, Gasthuisberg University Hospital, Leuven (Belgium)

    2003-09-01

    Fluorine-18 fluorodeoxyglucose positron emission tomography ({sup 18}FDG PET) plays a major role in the management of oncology patients. Owing to the singular properties of the glucose tracer, many patients suffering from non-malignant diseases such as inflammatory or infectious diseases may also derive clinical benefit from the appropriate use of metabolic imaging. Large vessel vasculitides such as giant cell arteritis and Takayasu arteritis are other examples that may potentially extend the field of {sup 18}FDG PET indications. The purpose of the present article is to assess the feasibility of metabolic imaging in vasculitis on the basis of the current literature data. In particular, the clinical context and the {sup 18}FDG imaging patterns seen in patients with large vessel vasculitis are analysed in order to identify potential indications for metabolic imaging. (orig.)

  5. Conditioned Place Preference to Acetone Inhalation and the Effects on Locomotor Behavior and 18FDG Uptake

    Energy Technology Data Exchange (ETDEWEB)

    Pai, J.C.; Dewey, S.L.; Schiffer, W.; Lee, D.

    2006-01-01

    Acetone is a component in many inhalants that have been widely abused. While other solvents have addictive potential, such as toluene, it is unclear whether acetone alone contains addictive properties. The locomotor, relative glucose metabolism and abusive effects of acetone inhalation were studied in animals using the conditioned place preference (CPP) paradigm and [18F]2-fluorodeoxy-D-glucose (18FDG) imaging. The CPP apparatus contains two distinct conditioning chambers and a middle adaptation chamber, each lined with photocells to monitor locomotor activity. Adolescent Sprague-Dawley rats (n=16; 90-110 g) were paired with acetone in least preferred conditioning chamber, determined on the pretest day. The animals were exposed to a 10,000 ppm dose for an hour, alternating days with air. A CPP test was conducted after the 3rd, 6th and 12th pairing. In these same animals, the relative glucose metabolism effects were determined using positron emission tomography (PET) imaging with 18FDG. Following the 3rd pairing, there was a significant aversion to the acetone paired chamber (190.9 ± 13.7 sec and 241.7 ± 16.9 sec, acetone and air, respectively). After the 6th pairing, there was no significant preference observed with equal time spent in each chamber (222 ± 21 sec and 207 ± 20 sec, acetone and air-paired, respectively). A similar trend was observed after the 12th pairing (213 ± 21 sec and 221 ± 22 sec, acetone and air-paired, respectively). Locomotor analysis indicated a significant decrease (p<0.05) from air pairings to acetone pairings on the first and sixth pairings. The observed locomotor activity was characteristic of central nervous system (CNS) depressants, without showing clear abusive effects in this CPP model. In these studies, acetone vapors were not as reinforcing as other solvents, shown by overall lack of preference for the acetone paired side of the chamber. PET imaging indicated a regionally specific distribution of 18FDG uptake following

  6. Clinical utility of F-18 FDG PET-CT in the initial evaluation of lung cancer

    DEFF Research Database (Denmark)

    Madsen, Poul Henning; Holdgaard, Paw Christian; Christensen, Janne Buck;

    2016-01-01

    PURPOSE: Positron emission tomography-computed tomography (PET-CT) is a resource-demanding imaging modality with increasing popularity in the workup of patients with suspected or proven lung cancer. METHODS: To review the clinical usefulness of this imaging modality in the diagnosis, staging...... the predefined criteria and were read in full to identify relevant original articles on F-18 FDG PET-CT (1) in the evaluation of solitary pulmonary nodules (n = 14), (2) in curative-intent treatment trials (n = 9), and (3) in planning of invasive procedures (n = 18). RESULTS: We found the following important...... results from the literature review: 1) PET-CT can rule out malignancy in most solitary pulmonary nodules due to high sensitivity (recommendation level A). 2) PET-CT reduces the number of futile treatment trials (recommendation level A). 3) The sensitivity of PET-CT in general is insufficient to rule out...

  7. Verbal memory deficits are correlated with prefrontal hypometabolism in (18FDG PET of recreational MDMA users.

    Directory of Open Access Journals (Sweden)

    Oliver G Bosch

    Full Text Available INTRODUCTION: 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy" is a recreational club drug with supposed neurotoxic effects selectively on the serotonin system. MDMA users consistently exhibit memory dysfunction but there is an ongoing debate if these deficits are induced mainly by alterations in the prefrontal or mediotemporal cortex, especially the hippocampus. Thus, we investigated the relation of verbal memory deficits with alterations of regional cerebral brain glucose metabolism (rMRGlu in recreational MDMA users. METHODS: Brain glucose metabolism in rest was assessed using 2-deoxy-2-((18Ffluoro-D-glucose positron emission tomography ((18FDG PET in 19 male recreational users of MDMA and 19 male drug-naïve controls. (18FDG PET data were correlated with memory performance assessed with a German version of the Rey Auditory Verbal Learning Test. RESULTS: As previously shown, MDMA users showed significant impairment in verbal declarative memory performance. PET scans revealed significantly decreased rMRGlu in the bilateral dorsolateral prefrontal and inferior parietal cortex, bilateral thalamus, right hippocampus, right precuneus, right cerebellum, and pons (at the level of raphe nuclei of MDMA users. Among MDMA users, learning and recall were positively correlated with rMRGlu predominantly in bilateral frontal and parietal brain regions, while recognition was additionally related to rMRGlu in the right mediotemporal and bihemispheric lateral temporal cortex. Moreover, cumulative lifetime dose of MDMA was negatively correlated with rMRGlu in the left dorsolateral and bilateral orbital and medial PFC, left inferior parietal and right lateral temporal cortex. CONCLUSIONS: Verbal learning and recall deficits of recreational MDMA users are correlated with glucose hypometabolism in prefrontal and parietal cortex, while word recognition was additionally correlated with mediotemporal hypometabolism. We conclude that memory deficits of MDMA users

  8. Myocardial glucose metabolism in patients with hypertrophic cardiomyopathy. Assessment by F-18-FDG PET study

    Energy Technology Data Exchange (ETDEWEB)

    Uehara, Toshiisa [Osaka Univ., Suita (Japan). Medical School; Ishida, Yoshio; Hayashida, Kohei [and others

    1998-04-01

    In an investigation of myocardial metabolic abnormalities in hypertrophic myocardium, the myocardial glucose metabolism was evaluated with F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) in 32 patients with hypertrophic cardiomyopathy, and the results were compared with those in 9 patients with hypertensive heart disease. F-18-FDG PET study was performed in the fasting and glucose-loading states. The myocardial regional %dose uptake was calculated quantitatively. The average regional %dose uptake in the fasting state in the patients with asymmetric septal hypertrophy and dilated-phase hypertrophic cardiomyopathy was significantly higher than that in the patients with hypertensive heart disease (0.75{+-}0.34%, 0.65{+-}0.25%, and 0.43{+-}0.22%/100 g myocardium, respectively). In contrast, the average %dose uptake in the glucose-loading state in the patients with asymmetric septal hypertrophy and dilated-phase hypertrophic cardiomyopathy was not significantly different from that in patients with hypertensive heart disease (1.17{+-}0.49%, 0.80{+-}0.44% and 0.99{+-}0.45%, respectively). The patients with apical hypertrophy had also low %dose uptake in the fasting state (0.38{+-}0.21%) as in the hypertensive heart disease patients, so that the characteristics of asymmetric septal hypertrophy and dilated-phase hypertrophic cardiomyopathy are considered to be high FDG uptake throughout the myocardium in the fasting state. Patients with apical hypertrophy are considered to belong to other disease categories metabolically. F-18-FDG PET study is useful in the evaluation of the pathophysiologic diagnosis of patients with hypertrophic cardiomyopathy. (author)

  9. Usefulness of F-18 FDG PET/CT in subcutaneous panniculitis-like T cell lymphoma: disease extent and treatment response evaluation.

    Science.gov (United States)

    Kim, Jin-Suk; Jeong, Young Jin; Sohn, Myung-Hee; Jeong, Hwan-Jeong; Lim, Seok Tae; Kim, Dong Wook; Kwak, Jae-Yong; Yim, Chang-Yeol

    2012-12-01

    BACKGROUND.: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare form of cutaneous lymphomas, accounting for less than 1% of cases of non-Hodgkin's lymphoma. Fluorine-18 fluorodeoxyglucose (F-18 FDG) positron-emission tomography/computed tomography (PET/CT) findings of SPTCL before and after treatment were rarely reported. CASE REPORT.: We report a case of SPTCL in which F-18 FDG PET/CT showed increased FDG accumulations in numerous subcutaneous nodules without extracutaneous disease. Contrast-enhanced CT during F-18 FDG PET/CT showed multiple minimally enhancing nodules with an infiltrative pattern in the subcutaneous layer throughout the body. Follow-up F-18 FDG PET/CT after three cycles of CHOP chemotherapy showed a complete metabolic remission of the lesions. CONCLUSIONS.: F-18 FDG PET/CT is suggested to be useful in assessing the disease activity, extent and treatment response in SPTCL.

  10. In Vivo Responses of Human A375M Melanoma to a sigma Ligand : F-18-FDG PET Imaging

    NARCIS (Netherlands)

    Rybczynska, Anna A.; de Bruyn, Marco; K. Ramakrishnan, Nisha; de Jong, Johan R.; Elsinga, Philip H.; Helfrich, Wijnand; Dierckx, Rudi A. J. O.; van Waarde, Aren

    2013-01-01

    sigma-ligands can kill tumor cells. Previously we have shown that a short in vitro incubation of C6 tumor cells with sigma-ligands (24 h) results in a dose-dependent increase of cellular F-18-FDG uptake and that the magnitude of this increase is predictive of subsequent cell death. Here, we aimed to

  11. Stores

    CERN Multimedia

    2004-01-01

    Following the introduction of Condensators, resistors and potentiometers from the Farnell electronic-catalogue into CERN Stores' catalogue, following products are now available: PRODUCT FAMILY GROUP SCEM Oscillators and quartz crystals 07.94.10 / 07.94.12 Diodes 08.51.14 / 08.51.54 Thyristors 08.51.60 / 08.51.66 Opto-electronics 08.52 Transistors 08.53 Integrated circuits 08.54 / 08.55 These articles can be procured in the same way as any other stores item, by completing a Material Request. N.B. Individual Farnell order codes can be used as keywords to facilitate searches in the CERN Stores Catalogue.

  12. The characteristics of syndrome X based on {sup 201}Tl-SPECT, {sup 18} FDG-PET and histopathologic findings

    Energy Technology Data Exchange (ETDEWEB)

    Satake, Osamichi [Kanazawa Medical Univ. (Japan)

    1999-03-01

    Syndrome X is a microvascular disease. However, the relationship between microvascular ischemia and histopathological findings remains unknown. The present study was performed to evaluate the myocardial perfusion and metabolism of patients with Syndrome X using {sup 201}Tl-SPECT and {sup 18}FDG-PET, and to clarify the morphological characteristics with a ventricular myocardial biopsy. We examined 24 patients with Syndrome X and 5 patients with myocarditis as a control group. In the study using {sup 201}Tl-SPECT and {sup 18}FDG-PET, we evaluated the presence or absence of myocardial ischemia. We calculated the Standardized Uptake Value (SUV) (%dose/ml) of {sup 18}FDG, and analyzed quantitatively the degree of ischemia. For histopathologic study on coronary microcirculation, we performed a right ventricular myocardial biopsy. The biopsies were examined light and electron microscopically. The semithin sections, stained with toluidine blue, were projected onto a screen. Microvessels were counted and the ratio of microvascular luminal narrowing and the number of microvessels per unit area were determined. The study using {sup 201}Tl-SPECT and {sup 18}FDG-PET showed that hypoperfusion of {sup 201}Tl was found in 17 of 24 (71%) patients during {sup 201}Tl-loaded myocardial scanning together with redistribution of {sup 201}Tl at the same regions; {sup 18}FDG-uptake were found in all 24 patients during {sup 18}FDG-PET performed under resting and fasting conditions; the SUV of {sup 18}FDG in the Syndrome X group (0.025{+-}0.039 %dose/ml) was significantly different from that of the control group (0.003{+-}0.002 %dose/ml) (p<0.01). Histopathological observations under the both light and electron microscope showed that an increment in number of the endothelial cells with swelling, a marked luminal narrowing due to the hypertrophy of the arteriolar media and the capillary walls, and a compression of the capillaries were shown in all the patients; the ratio of luminal narrowing

  13. Very low-dose adult whole-body tumor imaging with F-18 FDG PET/CT

    Science.gov (United States)

    Krol, Andrzej; Naveed, Muhammad; McGrath, Mary; Lisi, Michele; Lavalley, Cathy; Feiglin, David

    2015-03-01

    The aim of this study was to evaluate if effective radiation dose due to PET component in adult whole-body tumor imaging with time-of-flight F-18 FDG PET/CT could be significantly reduced. We retrospectively analyzed data for 10 patients with the body mass index ranging from 25 to 50. We simulated F-18 FDG dose reduction to 25% of the ACR recommended dose via reconstruction of simulated shorter acquisition time per bed position scans from the acquired list data. F-18 FDG whole-body scans were reconstructed using time-of-flight OSEM algorithm and advanced system modeling. Two groups of images were obtained: group A with a standard dose of F-18 FDG and standard reconstruction parameters and group B with simulated 25% dose and modified reconstruction parameters, respectively. Three nuclear medicine physicians blinded to the simulated activity independently reviewed the images and compared diagnostic quality of images. Based on the input from the physicians, we selected optimal modified reconstruction parameters for group B. In so obtained images, all the lesions observed in the group A were visible in the group B. The tumor SUV values were different in the group A, as compared to group B, respectively. However, no significant differences were reported in the final interpretation of the images from A and B groups. In conclusion, for a small number of patients, we have demonstrated that F-18 FDG dose reduction to 25% of the ACR recommended dose, accompanied by appropriate modification of the reconstruction parameters provided adequate diagnostic quality of PET images acquired on time-of-flight PET/CT.

  14. Solitary Plasmacytoma of the Sternum Mimicking Bone Metastasis in a Patient with a History of Breast Cancer Evaluated by F-18-FDG PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Treglia, Giorgio; Luca, Giovanella [Oncology Institute of Southern Switzerland, Bellinzona (Switzerland); Barbara, Muoio; Carmelo, Caldarella [Catholic Univ., Rome (Italy)

    2014-06-15

    A 65-year-old woman with a history of breast cancer (stage T2N0M0 treated with left breast conservative therapy 7 years previously followed by hormone therapy) underwent fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT) for restaging due to increased serum tumour markers levels (CA15-3, 37 U/ml and CEA, 8 ng/ml). The patient presented thoracic pain before performing F-18-FDG PET/CT. PET/CT demonstrated an area of increased F-18-FDG uptake corresponding to an osteolytic lesion occupying the upper sternum suspicious for bone metastasis. No other areas of abnormal F-18-FDG uptake were detected in the rest of the body. Based on this PET/CT finding, the patient performed biopsy of the sternal lesion. Histology demonstrated the presence of a sternal plasmacytoma and the patient was addressed to radiation therapy. The role of F-18-FDG PET/CT in patients with multiple myeloma is well known, whereas only some articles evaluated the usefulness of this method in patients with solitary plasmacytomas. In particular, F-18-FDG PET/CT may be useful in demonstrating the evolution of solitary plasmacytomas in multiple myeloma. In our case F-18-FDG PET/CT was useful in detecting a solitary plasmacytoma of the sternum mimicking bone metastasis in a patient with history of breast cancer, correctly addressing to further histological evaluation.

  15. Prognostic value and clinical impact of 18FDG-PET in the management of children with Burkitt lymphoma after induction chemotherapy.

    Directory of Open Access Journals (Sweden)

    clement eBailly

    2014-12-01

    Full Text Available Objective: Burkitt Lymphoma (BL is a rare and aggressive form of B cell lymphoma that is curable using intensive chemotherapy. Obtaining a complete response (CR at the end of induction chemotherapy is a major prognostic factor. This study retrospectively evaluates the potential impact of 18FDG-PET in the management of children with BL after induction chemotherapy, and the prognostic performance of the Deauville criteria.Methods: 19 children with BL treated according to the French LMB2001 protocol between 2005 and 2012 were included. 18FDG-PET and conventional imaging (CI were performed after induction chemotherapy to confirm CR. 18FDG-PET was interpreted according to Deauville criteria with follow up and/or histology as the gold standard.Results: 18FDG-PET was negative in 15 cases, in agreement with CI in 9/15 cases. The six discordant cases confirmed to be negative by histology, were considered as true negative for 18FDG-PET. Negative predictive value (NPV of CI and 18FDG-PET were 73 and 93% respectively. The five-year PFS was significantly higher in patients with negative 18FDG-PET than those with positive 18FDG-PET (p=0.011. Conclusion: 18FDG-PET interpreted using Deauville criteria can help confirm CR at the end of induction chemotherapy, with a prognostic impact on five-year PFS. Its high NPV could limit the use of residual mass biopsy. Given the small size of our population, these results need to be confirmed by future prospective studies on a larger population.

  16. SPECT Imaging of Epilepsy: An Overview and Comparison with F-18 FDG PET

    Directory of Open Access Journals (Sweden)

    Sunhee Kim

    2011-01-01

    Full Text Available Epilepsy surgery is highly effective in treating refractory epilepsy, but requires accurate presurgical localization of the epileptogenic focus. Briefly, localization of the region of seizure onset traditionally dependents on seizure semiology, scalp EEG recordings and correlation with anatomical imaging modalities such as MRI. The introduction of noninvasive functional neuroimaging methods, including single-photon emission computed tomography (SPECT and positron emission tomography (PET has dramatically changed the method for presurgical epilepsy evaluation. These imaging modalities have become powerful tools for the investigation of brain function and are an essential part of the evaluation of epileptic patients. Of these methods, SPECT has the practical capacity to image blood flow functional changes that occur during seizures in the routine clinical setting. In this review we present the basic principles of epilepsy SPECT and PET imaging. We discuss the properties of the SPECT tracers to be used for this purpose and imaging acquisition protocols as well as the diagnostic performance of SPECT in addition to SPECT image analysis methods. This is followed by a discussion and comparison to F-18 FDG PET acquisition and imaging analysis methods.

  17. Radiation assessment to paediatric with F-18-FDG undergo whole-body PET/CT examination

    Energy Technology Data Exchange (ETDEWEB)

    Dhalisa, H., E-mail: dhalisa82@gmail.com; Rafidah, Z. [Kluster Oncology Science and Radiology, Advanced Medical Dental Institute, Universiti Sains Malaysia (USM), Bertam, Penang (Malaysia); Mohamad, A. S. [Department of Nuclear Medicine, National Cancer Institute, No 4 Jalan P7, Presint 7, Putrajaya (Malaysia)

    2016-01-22

    This study was carried out on wholebody radiation dose assessment to paediatrics patient who undergo PET/CT scanner at Institut Kanser Negara. Consist of 68 patients with varies of malignancies and epilepsy disease case covering age between 2 years to 12 years old. This is a retrospective study from 2010-2014. The use of PET/CT scanner as an advanced tool has been proven to give an extra radiation dose to the patient. It is because of the radiation exposure from the combination of both CT and PET scans rather than a single CT or PET scan. Furthermore, a study on radiation dose to paediatric patient undergoing PET/CT is rare in Malaysia. So, the aim of this study is to estimate the wholebody effective dose to paediatric patient in Malaysia. Effective dose from PET scan was calculated based on the activity of F18 FDG and dose coefficient reported in International Commission on Radiological Protection (ICRP) Publication 106. Effective dose from CT was determined using k coefficient as reported in ICRP publication 102 and Dose Length Product (DLP) value. The average effective dose from PET and CT were found to be 7.05mSv and 5.77mSv respectively. The mean wholebody effective dose received by a patient with combined PETCT examination was 12.78mSv. These results could be used as reference for dosimetry of a patient undergoing PETCT examination in Malaysia.

  18. Potential Opponent for 18FDG: Gd3+-DTPA-DG: A New Synthetic MRI Contrast Agent

    Directory of Open Access Journals (Sweden)

    Mehdi Shafiee Ardestani

    2010-05-01

    Full Text Available Glucose mediated imaging tools have recently be-come an area of research interest in the field of nuclear medicine, especially Positron Emission Tomography (PET imaging. The difficulties in the use, preparation and cost of radioactively-labeled glycosylated compounds led to the research and development in this present study of a new gadolinium-labeled glucose that does not have a radioactive half-life or difficulties in its synthesis and utilization. Based on the structure of fluorodeoxyglucose (18FDG, a new compound consisting of a D-glucose conjugated to a well-known chelator DTPA was synthesized, labeled with Gd3+ and examined in vitro and in vivo. The results showed a good anti-cancer potency for the prepared complex. Gd3+ -DTPA-DG did not produce any significant alteration in the blood glucose level and was also phosphorylated by hexokinase enzyme. In vitro relaxation times T1 and T2 were determined and compared with a standard compound Magnevist®. Finally, imaging studies were performed in tumor-bearing mice and the tumor areas were shown successfully. This compound may have great potential in the future in radio-oncology.

  19. Current concepts in F18 FDG PET/CT-based Radiation Therapy planning for Lung Cancer

    Directory of Open Access Journals (Sweden)

    Percy eLee

    2012-07-01

    Full Text Available Radiation therapy is an important component of cancer therapy for early stage as well as locally advanced lung cancer. The use of F18 FDG PET/CT has come to the forefront of lung cancer staging and overall treatment decision-making. FDG PET/CT parameters such as standard uptake value and metabolic tumor volume provide important prognostic and predictive information in lung cancer. Importantly, FDG PET/CT for radiation planning has added biological information in defining the gross tumor volume as well as involved nodal disease. For example, accurate target delineation between tumor and atelectasis is facilitated by utilizing PET and CT imaging. Furthermore, there has been meaningful progress in incorporating metabolic information from FDG PET/CT imaging in radiation treatment planning strategies such as radiation dose escalation based on standard uptake value thresholds as well as using respiratory gated PET and CT planning for improved target delineation of moving targets. In addition, PET/CT based follow-up after radiation therapy has provided the possibility of early detection of local as well as distant recurrences after treatment. More research is needed to incorporate other biomarkers such as proliferative and hypoxia biomarkers in PET as well as integrating metabolic information in adaptive, patient-centered, tailored radiation therapy.

  20. Impact of F-18 FDG-PET for the Clinical Multidisciplinary Evaluation of Dementia

    DEFF Research Database (Denmark)

    Prakash, Vineet; Vestergård, Karsten; Frost, Majbritt;

    .                       CONCLUSION            F-18 FDG-PET changed management in 44 % of patients seen in a specialist mutlidisciplinary dementia clinic.PET has promising clinical value for management decisions in patients where clinical evaluations combined with lab CSF results and dedicated MR imaging are equivocal for Alzheimers......PURPOSE            Dementia is a challenging clinical diagnosis. Compared with conventional clinical evaluations, F-18 Fluorodeoxyglucose (FDG) PET has been reported to improve not only the diagnostic accuracy of dementia but also help better define the underlying  type. This is because FDG PET...... demonstrates metabolic patterns reflecting neuronal function specific to different dementias.To assess the impact of PET on a multidisciplinary  dementia clinic for patients with suspected dementia by comparing it with the initial clinical evaluation and paraclinical tests.                       METHOD...

  1. A Case of Urethral Metastasis from Sigmoid Colon Cancer Diagnostically and Prognostically Indicated by F 18 FDG PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Han Seok; Kim, Eun Sil; Kim, Soyon; Im, Su Jin; Park, Yong Hyun; Lee, Ju Hyoung; Hur, So Chong [National Police Hospital, Seoul (Korea, Republic of)

    2011-12-15

    Urethral metastasis from colorectal cancer is rare and is known to have a poor prognosis. A 72 year old man with a history of colectomy and colostomy due to sigmoid colon cancer was admitted to the emergency room with bowel distension, rectal bleeding and urinary symptoms. Computed tomography of the abdominopelvis showed sigmoid colon cancer with multiple metastases involving the liver. Positron emission tomography with F 18 fluorodeoxyglucose (FDG) showed multiple hypermetabolic foci in the liver, penis and pubic bone, which otherwise could not be diagnosed. The lesions revealed no improvement with chemotherapy and urological surgery on follow up F 18 FDG PET/CT. We present a case of urethral metastasis of sigmoid colon cancer diagnostically and prognostically indicated by F 18 FDG PET/CT.

  2. Rapidly growing complex fibroadenoma with surrounding ductal hyperplasia mimics breast malignancy on serial F-18 FDG PET/CT imaging.

    Science.gov (United States)

    Makis, William; Ciarallo, Anthony; Hickeson, Marc; Derbekyan, Vilma

    2011-07-01

    A 30-year-old woman was referred for an F-18 fluorodeoxyglucose (FDG) PET/CT to rule out lymphoma, and was found to have an incidental FDG-avid right breast nodule that grew significantly in size and FDG uptake on a subsequent scan, raising suspicion of a growing breast malignancy. Histologic evaluation showed a complex fibroadenoma with adenosis and surrounding ductal hyperplasia. Although variable F-18 FDG uptake in fibroadenomas has been described, a distinction between simple and complex fibroadenomas has not been made in the PET literature, even though complex fibroadenomas have a higher propensity to develop into malignancies. This case shows that a rapidly growing complex fibroadenoma can mimic a breast malignancy on serial F-18 FDG PET/CT scans, showing significant increase in both size and FDG-avidity on follow-up studies.

  3. F18-FDG-PET/CT for evaluation of intraductal papillary mucinous neoplasms (IPMN): a review of the literature.

    Science.gov (United States)

    Bertagna, Francesco; Treglia, Giorgio; Baiocchi, Gian Luca; Giubbini, Raffaele

    2013-04-01

    Intraductal papillary mucinous neoplasms (IPMN) are intraductal mucin-producing neoplasms with tall columnar, mucin-containing epithelium, with or without papillary projections, involving the main pancreatic duct and/or major side branches. They account for approximately 25 % of all cystic neoplasms and can be subdivided into benign lesions, borderline lesions, and carcinoma. In this clinical scenario accurate preoperative diagnosis can eliminate unnecessary surgery, which is risky and potentially harmful, yet enable effective selection of patients who are candidates for surgery. In this review we try to provide a complete evaluation of the use of F18-FDG-PET/CT for diagnosis of this neoplasm on the basis of published papers. F18-FDG-PET/CT seems to be an useful technique for preoperative work-up of patients with suspected IPMN and is an improvement over conventional imaging in distinguishing benign from malignant lesions, especially for selecting patients for surgical treatment or for long-term follow-up.

  4. Correlation of Glut-1 and Glut-3 expression with F-18 FDG uptake in pulmonary inflammatory lesions

    OpenAIRE

    Wang, Zhen Guang; Yu, Ming Ming; Han, Yu; Wu, Feng Yu; Yang, Guang Jie; Li, Da Cheng; Liu, Si Min

    2016-01-01

    Abstract The aim of the study was to investigate the correlation of glucose transporter-1 (Glut-1) and glucose transporter-3 (Glut-3) expression with F-18 FDG uptake in pulmonary inflammatory lesions. Twenty-two patients with pulmonary inflammatory lesions underwent positron emission tomography/computed tomography (PET/CT) examination preoperatively, and Glut-1 and Glut-3 expression were detected by immunohistochemistry in these lesions. Correlations of Glut-1 and Glut-3 with 18F-FDG uptake w...

  5. Correlation of Glut-1 and Glut-3 expression with F-18 FDG uptake in pulmonary inflammatory lesions.

    Science.gov (United States)

    Wang, Zhen Guang; Yu, Ming Ming; Han, Yu; Wu, Feng Yu; Yang, Guang Jie; Li, Da Cheng; Liu, Si Min

    2016-11-01

    The aim of the study was to investigate the correlation of glucose transporter-1 (Glut-1) and glucose transporter-3 (Glut-3) expression with F-18 FDG uptake in pulmonary inflammatory lesions.Twenty-two patients with pulmonary inflammatory lesions underwent positron emission tomography/computed tomography (PET/CT) examination preoperatively, and Glut-1 and Glut-3 expression were detected by immunohistochemistry in these lesions. Correlations of Glut-1 and Glut-3 with F-FDG uptake were assessed using Spearman's rank correlation test.The maximum standardized uptake value (SUVmax) of pulmonary inflammatory lesions in 22 patients was 0.50 to 7.50, with a mean value of 3.66 ± 1.62. Immunohistochemical staining scores of Glut-1 and Glut-3 were 2.18 ± 0.96 and 2.82 ± 1.37, respectively. The expression of Glut-1 and Glut-3 was positively correlated with F-18 FDG uptake. Glut-3 expression was evidently higher than Glut-1 expression in 22 patients.Glut-1 and Glut-3 expressions are high in pulmonary inflammatory lesions, and Glut-3 plays a more important role in F-18 FDG uptake in pulmonary inflammatory lesions.

  6. Usefulness of F-18 FDG PET/CT in subcutaneous panniculitis-like T cell lymphoma: disease extent and treatment response evaluation

    OpenAIRE

    Kim, Jin-Suk; Jeong, Young Jin; Sohn, Myung-Hee; Jeong, Hwan-Jeong; Lim, Seok Tae; KIM, Dong Wook; Kwak, Jae-Yong; Yim, Chang-Yeol

    2012-01-01

    Background. Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare form of cutaneous lymphomas, accounting for less than 1% of cases of non-Hodgkin’s lymphoma. Fluorine-18 fluorodeoxyglucose (F-18 FDG) positron-emission tomography/computed tomography (PET/CT) findings of SPTCL before and after treatment were rarely reported. Case report. We report a case of SPTCL in which F-18 FDG PET/CT showed increased FDG accumulations in numerous subcutaneous nodules without extracutaneous disea...

  7. Construction and evaluation of F-18 FDG PET probabilistic MAP for voxel based analysis of the rat brain

    Energy Technology Data Exchange (ETDEWEB)

    Im, K. C.; Kim, J. S.; Na, Y. S.; Moon, D. H.; Ryu, J. S. [Asan Medical Center, Seoul (Korea, Republic of)

    2007-07-01

    The purpose of this study was to develop F-18 FDG PET and MRI template for normal rat brain. Also, feasibility of SPM in detailed regional analysis of molecular changes in the rat brain was explored for F-18 FDG PET imaging of a model of traumatic brain injury (TBI). Ten normal rats were scanned with PET and MRI. The PET images were acquired with 3D mode using microPET focus 120 scanner after injection of 37 MBq F-18 FDG. T2-weighted MR images were acquired using 4.7T MRI system. A MRI-based spatial normalization was used. The PET images were coregistered to T2-weighted MR images. Maximum mutual information (MMI) registrations and affine spatial normalizations were performed using SPM2. The spatial normalization of the MRI to the standard MRI was applied to the integral images. The normalized PET images were averaged voxel wise to create PET template. Eight TBI model rats were subjected to a moderate lateral fluid percussion injury. At 2 days, 1 week, 3 weeks and 5 weeks post FPI, PET images of 8 TBI rats were acquired 4 times. TBI PET images were realigned, spatially normalized to a created PET-template and smoothed (8 mm FWHM). To assess the extent and severity of significant hypo metabolic lesions in TBI compared to normal controls were obtained by a two-sided t-test of SPM (uncorrected p < 0.001, 50 voxels). Visually acceptable PET and MRI templates were created. Registration errors were negligible when MMI procedure was used to register a translated or rotated image volume. Thirty-two PET studies of 8 TBI model subjects were obtained. SPM analysis showed injured distribution of decrease F-18 FDG uptake in TBI rats compared with normal rats. In SPM analysis, the extent and severity of significant hypo metabolic lesions were decreased according to a significant effect of time. At 5 weeks injured animals showed F-18 FDG uptake recovery using SPM analysis. These results indicate that voxel-based method will be useful for future longitudinal studies of rat brain.

  8. Pyelo-cystic Reflux in F-18 FDG PET Scan Due to Ureteral Obstruction

    Energy Technology Data Exchange (ETDEWEB)

    Reyhan, Mehmet [Baskent Univ., Adana (Turkmenistan)

    2013-09-15

    A 72-year-old woman with a history of cervical cancer was treated with brachytherapy and chemotherapy. Combined F-18 FDG PET/CT performed for restaging demonstrated increased FDG uptake in a hypodense cystic lesion at the posterior part of the right renal cortex and a hypermetabolic soft tissue mass at the right parailiac region suggestive of a metastatic lymph node causing ureteral obstruction. There had been no FDG uptake in the cystic lesion on the FDG PET/CT study performed 1 year before. These findings suggest that the increased FDG uptake in the cystic lesion was caused by pyelocystic reflux due to ureteral obstruction secondary to parailiac lymph node metastasis (Figs. 1 and 2). Several renal lesions may have increased metabolism, such as renal cell carcinoma, lymphoma, oncocytoma, adult Wilms' tumor, angiomyolipoma, metastatic lesions, xanthogranulo-matous pyelonephritis and infected cyst. Most of these lesions are solid. Some infected renal cysts may be FDG avid, but in this situation increased FDG uptake is observed on the wall of the cyst. In our case, FDG uptake was seen in the entire cystic lesion. The patient had no symptoms or laboratory findings related to infection. Cysts are the most common space-occupying lesions of the kidney. The vast majority of these are simple cysts that are usually unilateral and solitary. Simple cysts are asymptomatic, except when complications exist such as hemorrhage, infection or rupture. There have been a few reports on spontaneous communications between renal cysts and the pyelocaliceal system, in most cases involving ruptures of the cysts into the pyelocaliceal system due to increased intracystic pressure caused by bleeding or infection of the cyst. In the present case, the cause of the connection between the cystic cavity and the pyelocaliceal system is the increased pressure in the renal pelvic cavity due to the ureteral obstruction secondary to parailiac lymph node metastasis.

  9. F18-FDG PET-CT analyses of small peripheral adenocarcinoma of the lung

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    Takahashi, Yoshiyuki; Takashima, Shodayu [Osaka Univ. Graduate School of Medicine, Div. of Allied Health Sciences, Dept. of Diagnostic Radiological Imaging, Osaka (Japan)], e-mail: yoshi_seat_128@yahoo.co.jp; Watanabe, Shinichiro [Osaka University Graduate School of Medicine, Department of Nuclear Medicine and Tracer Kinetics, Osaka (Japan)

    2013-03-15

    Background: Radiological discrimination of histologic subtypes of small peripheral adenocarcinoma of the lung is clinically important. Although there are many articles in which CT findings were used for this purpose, there are only a few reports on the capability of FDG PET-CT findings for histologic classification of this tumor. Purpose: To investigate the correlation between visual assessment or maximum standard uptake values (SUVmax) on F18-FDG PET-CT and histology grading of small peripheral adenocarcinoma of the lung. Material and Methods: Proportions of positive PET-CT diagnoses and SUVmax were retrospectively reviewed on 96 solitary pulmonary nodules of {<=}2 cm in 90 consecutive patients. Tumors were classified into four groups according to Noguchi's classification (group 1 [n = 10], atypical adenomatous hyperplasia and type A tumors; group 2 [n = 12], type B tumors; group 3 [n = 42], type C tumors; group 4 [n = 32], types D, E, and F tumors). Proportions of positive PET-CT diagnoses and mean SUVmax of lesions among four groups were compared using trend tests to examine if there is a significant linear correlation with the progression of the histology grading of tumors. Then, an optimal threshold of SUVmax was proposed to best discriminate tumors of poor (groups 3 and 4) from good (groups 1 and 2) prognosis. Results: There was a significant linear trend for both visual assessment (P < 0.01) and SUVmax (P < 0.01). A SUVmax of 0.42 showed the highest accuracy of 84% with 95% sensitivity and 50% specificity for predicting tumors of poor prognosis. A SUVmax of 2.05 showed 100% specificity with 49% sensitivity, and 60% accuracy. Positive visual diagnoses showed accuracy of 83% with 90% sensitivity and 59% specificity. Conclusion: Visual assessment and SUVmax on PET-CT correlated well with the histology grading of small peripheral adenocarcinoma of the lung.

  10. Clinical utility of F-18 FDG PET-CT in the initial evaluation of lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Madsen, Poul Henning [Vejle Hospital, Department of Medicine, Division of Respiratory Medicine, Vejle (Denmark); Holdgaard, Paw Christian [Vejle Hospital, Department of Nuclear Medicine, Vejle (Denmark); Christensen, Janne Buck [Odense University Hospital/University of Southern Denmark, Department of Quality and Research/HTA, Odense University Hospital and Medical Research Library, Odense (Denmark); Hoeilund-Carlsen, Poul Flemming [Odense University Hospital, Department of Nuclear Medicine, Odense (Denmark)

    2016-10-15

    Positron emission tomography-computed tomography (PET-CT) is a resource-demanding imaging modality with increasing popularity in the workup of patients with suspected or proven lung cancer. To review the clinical usefulness of this imaging modality in the diagnosis, staging, and pre-operative evaluation, we conducted a systematic literature search, review, and quality assessment using the rapid evidence assessment toolkit and the Oxford Centre for Evidence-Based Medicine methodology. The literature search resulted in 4,208 records including 918 reviews, of which 139 met the predefined criteria and were read in full to identify relevant original articles on F-18 FDG PET-CT (1) in the evaluation of solitary pulmonary nodules (n = 14), (2) in curative-intent treatment trials (n = 9), and (3) in planning of invasive procedures (n = 18). We found the following important results from the literature review: (1) PET-CT can rule out malignancy in most solitary pulmonary nodules due to high sensitivity (recommendation level A). (2) PET-CT reduces the number of futile treatment trials (recommendation level A). (3) The sensitivity of PET-CT in general is insufficient to rule out mediastinal lymph node metastasis (recommendation level A). (1) With few exceptions, solitary pulmonary nodules can safely be considered benign if the PET-CT scan is negative. Exceptions consist of small (<1 cm) and non-solid, solitary pulmonary nodules. These abnormalities should be followed up by CT in a structured programme. (2) No curative-intent treatment should be commenced until a PET-CT scan has excluded occult distant metastases. (3) In general, lymph node metastasis in the mediastinum cannot be ruled out on the basis of a negative PET-CT, and confirmative invasive staging should be performed in most patients before mediastinal metastasis is confirmed or ruled out. (orig.)

  11. In vivo monitoring of occupationally exposed individuals to {sup 18}FDG in CRCN/NE; Monitoracao in vivo dos individuos ocupacionalmente expostos na producao de {sup 18}FDG no CRCN/NE

    Energy Technology Data Exchange (ETDEWEB)

    Lacerda, I.V.B. [Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE/CNEN-PE), Recife, PE (Brazil); Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Programa de Pos-Graduacao em Tecnologias Energeticas e Nucleares; Xavier, A.C.S.; Oliveira, M.L.; Lima, F.F.; Lima, F.R.A., E-mail: bellelacerda@hotmail.com [Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE/CNEN-PE), Recife, PE (Brazil)

    2012-07-01

    The increasing demand for PET radiopharmaceuticals in Brazil results in increasing of the number of occupationally exposed individuals (OEI) to the radiopharmaceutical {sup 18}F in the form of {sup 18}FDG, increasing thereby the risk of accidental incorporation. This work aims to implement an in vivo internal monitoring technique applied to {sup 18}FDG radiopharmaceutical at the Divisao de Producao de Radiofarmacos (DIPRA) of the Centro Regional de Ciencias Nucleares do Nordeste (CRCN/NE). The detection system used was a NaI(Tl) 3'' x 3'' detector connected to a compact electronic module operated by the Genie 2000 software. It was calibrated using a brain phantom containing a standard source of {sup 22}Na which simulates a contaminated individual. Based on the calibration factor it was possible to determine the minimum detectable activity (MDA) of the detection system and then, through use of biokinetic models provided by the ICRP in its publication 53 and edited by the AIDE version 6.0 software, it was possible to calculate the minimum detectable effective dose (MDED) which is an indication of the technique sensitivity. The MDED was estimated for the in vivo measurements performed up to 0.1 day after the occurrence of an intake by ingestion. The value obtained was compared to the Recording level of 1 mSv recommended by the IAEA. After validation of the in vivo monitoring technique, a series of measurements were performed on a group of occupationally exposed workers from DIPRA shortly after completion of production and quality control of {sup 18}FDG radiopharmaceutical procedures. It is concluded that the proposed technique is sufficiently sensitive for its application in internal occupational monitoring. (author)

  12. Granulomatous prostatitis after intravesical bacillus Calmette-Guérin instillation therapy: A potential cause of incidental F-18 FDG uptke in the prostate gland on F-18 FDG PET/CT in patients with bladder cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Choon Young; Lee, Sang Woo; Choi, Seock Hwan; Son, Seung Hyun; Jung, Ji Hoon; Lee, Chang Hee; Jeong, Shin Young; Ahn, Byeong Cheol; Lee, Jae Tae [Kyungpook National University Medical Center and School of Medicine, Daegu (Korea, Republic of)

    2016-03-15

    This study aimed to evaluate the possibility that Bacillus Calmette-Guérin (BCG)-induced granulomatous prostatitis can be a potential cause of benign F-18 FDG uptake. A total of 395 bladder cancer patients who underwent F-18 FDG PET/CT (PET/CT) were retrospectively evaluated. Patients were divided into two groups according to BCG therapy status. Elapsed time after BCG therapy, serum PSA level, results of prostate biopsy, and the SUV{sub max} and uptake pattern in the prostate gland were reviewed. For patients who underwent follow-up PET/CT, the changes in SUV{sub max} were calculated. While 35 % of patients showed prostate uptake in the BCG therapy group, only 1 % showed prostate uptake in the non-BCG therapy group (p < 0.001). Among 49 patients with FDG-avid prostate lesions, none had suspected malignancy during the follow-up period (median: 16 months). Five patients revealed granulomatous prostatitis on biopsy. The incidence of FDG-avid prostate lesions was significantly higher if the elapsed time after BCG therapy was less than 1 year compared to more than 1 year (p < 0.001). Serum PSA was normal in 88 % of patients. All patients with incidental F-18 FDG uptake in the prostate gland showed focal or multifocal prostate uptake, and median SUV{sub max} was 4.7. In 16 patients who underwent follow-up PET/CT, SUV{sub max} was decreased in 14 patients (88 %) without treatment, and no patients demonstrated further increased prostate uptake (p < 0.001). BCG-induced granulomatous prostatitis can be a potential cause of benign F-18 FDG uptake, especially in those with a history of bladder cancer treated with BCG. In BCG-induced granulomatous prostatitis, focal or multifocal prostate uptake is frequently seen within 1 year after BCG therapy, and the intensity of prostate uptake is decreased on the follow-up PET/CT without any treatment.

  13. Development of methodologies for internal exposure assessment due to the radiopharmaceutical {sup 18}FDG; Desenvolvimento de metodologias para avaliacao da exposicao ocupational interna devido ao radiofarmaco {sup 18}FDG

    Energy Technology Data Exchange (ETDEWEB)

    Lacerda, Isabelle Viviane Batista de

    2013-07-01

    The production of {sup 18}F has increased in the last decade. It is produced basically for the synthesis of {sup 18}F- fluorodeoxyglucose ({sup 18}FDG), the main radiopharmaceutical used in PET (Positron Emission Tomography) scans. The growth in the frequency of these tests resulted in rise of the number of occupationally exposed individuals (OEI) to the radionuclide {sup 18}F as {sup 18}FDG, increasing thereby the probability of its accidental incorporation. This study aimed to implement optimized techniques for assessing internal exposures of individuals occupationally exposed through both in vivo and in vitro bioassay methods during production and handling of {sup 18}FDG at the Divisao de Producao de Radiofarmacos (DIPRA), Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE/CNEN). The in vivo monitoring was conducted at the Laboratorio de Dosimetria Interna, Divisao de Laboratorios Tecnico-Cientificos (DILAB). For this bioassay method, measurements were done with a 3x3' NaI(Tl) scintillation detector coupled to Genie 2000 software. The calibration of the system was performed with a brain phantom containing a standard liquid source of {sup 22}Na to simulate a contaminated individual. The calibration of the HPGe coaxial detector for in vitro monitoring was performed at the Laboratorio de Medidas de Atividade de Radionuclideos (DIPRA/CRCN-NE/CNEN) with a standard source of {sup 22}Na. Base on the calibration factors, it was possible to determine the minimum detectable activities (MDA) for the systems by using direct measurements and simulation of uncontaminated urine. Then, through the biokinetic models published by ICRP 106 and edited by the AIDE software (version 6.0), it was possible to estimate the minimum detectable effective dose (MDED), which evaluates the detection sensitivity of the techniques developed. The MDED was estimated for in vivo and in vitro measurements performed 2.4 hours after the occurrence of incorporation by ingestion, since

  14. The role of F18-FDG PET scans in predicting micropapillary thyroid cancer aggressiveness

    Energy Technology Data Exchange (ETDEWEB)

    Cho, E. H.; Cho, H. J.; Kim, T. S.; Kang, W. J.; Yun, M. J.; Lee, J. D. [Severance Hospital, Seoul (Korea, Republic of)

    2007-07-01

    The purpose is to evaluate F18-FDG PET in predicting micropapillary thyroid cancer aggressiveness. 41 patients (38 female, mean age 50y) who had PET before total thyroidectomy between 2002.1{approx}2007.8 were reviewed. Patients with thyroiditis and multiple nodules were excluded. Thyroid nodules were visually analyzed into groups with increased and no FDG uptake. Peak SUV ratio of liver-to-nodule (pSUV ratio) was taken. pSUV ratio was correlated with nodule size and micropapillary cancer aggressiveness. Perithyroid extension and/or LN metastasis was used as an indicator of micropapillary cancer aggressiveness 20 patients had 0.89 and nodules with increased FDG uptake, with an average pSUV ratio of 1.67 0.15. 21 patients had nodules that were not visible, average size of 0.66 cm 0.24. FDG uptake and nodule size correlation was with an average size of 0.52 cm significant (p=0.051). The nodules were divided into two groups using a cut-off value of pSUV ratio of 0.9. 19 patients had nodules with a pSUV ratio of 0.9 or higher, and 15 of the 19 patients had perithyroid extension and/or LN metastasis. 22 patients had nodules with pSUV ratio lower than 0.9 and 7 of these patients had perithyroid extension and/or LN metastasis. Patients with higher pSUV ratio showed more perithyroid extension or LN metastasis than those with lower pSUV ratio (p=0.01). A total of 8 patients had LN metastasis, but none were visualized on PET. Higher FDG uptake seems to be significantly correlated with tumor aggressiveness in micropapillary thyroid carcinomas. But FDG uptakes in primary tumors were also correlated with tumor size. In other words, larger nodules tend to show aggressive behavior in micropapillary thyroid carcinomas and FDG it self may not be an independent factor for tumor aggressiveness. Also, PET shows an extremely poor sensitivity for the detection of LN metastasis. Therefore, PET may not have any role in the evaluation of patients with micropapillary thyroid carcinomas.

  15. Effect of the dilution factor on {sup 18}FDG and Na{sup 18}F samples for bacterial endotoxin test using PTS (portable test system)

    Energy Technology Data Exchange (ETDEWEB)

    Silveira, Marina B.; Costa, Flavia M.; Ferreira, Soraya Z., E-mail: mbs@cdtn.b [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil). Unidade de Pesquisa e Producao de Radiofarmacos

    2011-07-01

    {sup 18}FDG and Na{sup 18}F are radiopharmaceuticals produced as sterile solutions suitable for intravenous administration, which must contain no more than 175 EV/V. The most commonly used approach to detect endotoxins is the gelclot technique that requires 60 minutes for results. For radiopharmaceuticals containing short-life radionuclides, such as {sup 18}F, there is an increasing interest for faster quality control methods. FDA licensed the Endosafe, PTS, a kinetic chromogenic endotoxin detection system that takes about 15 minutes for results. As other techniques, PTS test is susceptible to interferences which can be solved by product dilution. The aim of this study was to establish the best dilution of {sup 18}FDG and Na{sup 18}F for PTS analysis. Two different dilution factors for {sup 18}FDG and 1:10 for Na{sup 18}F were essayed: 1:10 and 1:100. {sup 18}FDG and Na{sup 18} solutions were prepared by the addition of LAL reagent water. Considering the assay acceptance criteria, the best dilution factor was 1:100 for {sup 18}FDG and 1:10 for Na{sup 18}F. The recovery of the product positive control was 98-12% for {sup 18}FDG 1:100 and 104-120% for Na{sup 18}F 1:10, which were, in both cases, within the specification (50-200%) and very close to 100%. Results obtained with these dilution studies were important to establish the most appropriate and non-interfering dilution factor for {sup 18}FDG and Na{sup 18}F routine endotoxin test. (author)

  16. Predictive value of intratumoral heterogeneity of F-18 FDG uptake for characterization of thyroid nodules according to Bethesda categories of fine needle aspiration biopsy results.

    Science.gov (United States)

    Kim, Seong-Jang; Chang, Samuel

    2015-12-01

    The current study was aimed to investigate the clinical value of intratumoral heterogeneity of F-18 FDG uptake for characterization of thyroid nodule (TN) with inconclusive fine-needle aspiration biopsy (FNAB) results. The current study enrolled 200 patients who showed F-18 FDG incidentaloma and were performed FNAB. The intratumoral heterogeneity of F-18 FDG uptake was represented as the heterogeneity factor (HF), defined as the derivative (dV/dT) of a volume-threshold function for a primary tumor. The diagnostic and predictive values of HF and F-18 FDG PET/CT parameters were evaluated for characterization of inconclusive FNAB results. Among F-18 FDG PET/CT parameters, SUVmax, MTV, and TLG of malignant group were statistically higher than those of Bethesda category of suspicious malignant group. However, HF values were not statistically different between the groups of Bethesda categories (Kruskal-Wallis statistics, 9.924; p = 0.0774). In ROC analysis, when HF > 2.751 was used as cut-off value, the sensitivity and specificity for prediction of malignant TN were 100 % (95 % CI 69.2-100 %) and 60 % (95 % CI 42.1-76.1 %), respectively. The AUC was 0.826 (95 % CI 0.684-0.922) and standard error was 0.0648 (p F-18 FDG uptake represented by HF could be a predictor for characterization of TN with inconclusive FNAB results. Additional large population-based prospective studies are needed to validate the diagnostic utility of HF of F-18 FDG PET/CT.

  17. Contribution of 18-FDG PET/CT to brown tumor detection in a patient with primary hyperparathyroidism.

    Science.gov (United States)

    Gahier Penhoat, Mélanie; Drui, Delphine; Ansquer, Catherine; Mirallie, Eric; Maugars, Yves; Guillot, Pascale

    2017-03-01

    We report the case of a patient who presented with multiple brown tumors as the inaugural manifestation of primary hyperparathyroidism. Tc-99m hexakis methoxyisobutylisonitrile (99mTc-MIBI) scintigraphy demonstrated increased radiotracer uptake by the bone lesions. The patient was a 65-year-old male who sought advice for a swelling on his right shin. An osteolytic lesion was visible on the radiograph. A bone biopsy showed a benign tumor containing abundant osteoclastic cells. Laboratory abnormalities included hypercalcemia (3.63mmol/L with 1.91mmol/L ionized calcium), hypophosphatemia (0.38mmol/L), and parathyroid hormone elevation (880.8pg/mL; N: 10-70). Serum 25-OH Vitamin D level was lower than 4ng/mL (N: 30-60). An 18-FDG PET/CT scan identified numerous high-uptake bone lesions. By 99mTc-MIBI scintigraphy, a large high-uptake mass was seen in the left parathyroid gland, as well as high-uptake lesions throughout the skeleton, which were less numerous than those seen by 18-FDG PET/CT. Ultrasonography of the neck visualized a mass consistent with an adenoma in the left parathyroid gland. Brown tumors are bone lesions whose diagnosis should be considered in patients with clinical and laboratory evidence of hyperparathyroidism, once a malignant disease is ruled out. Our case report suggests that 18-FDG PET/CT may be more sensitive than whole-body 99mTc-MIBI scintigraphy in detecting brown tumors.

  18. Usefulness of F-18 FDG PET/CT in a case of Kaposi sarcoma with an unexpected bone lesion.

    Science.gov (United States)

    Morooka, Miyako; Ito, Kimiteru; Kubota, Kazuo; Yanagisawa, Kunio; Teruya, Katsuji; Hasuo, Kahehiro; Shida, Yoshitaka; Minamimoto, Rhogo; Kikuchi, Yoshimi; Oka, Shinichi

    2011-03-01

    Bone lesions of Kaposi sarcoma are rare. A 56-year-old man who was HIV positive and was diagnosed with Kaposi sarcoma on the basis of the results of a biopsy of skin lesions, underwent F-18 FDG PET/CT scan for detecting Kaposi sarcoma lesions and other AIDS-related diseases. An abnormal uptake was observed in the lumbar spine. MRI showed a diffuse enhanced spine lesion, and Ga-67 and ²⁰¹Tl scanning were negative. As a result, the lesion was considered to be a Kaposi sarcoma, and the shrinkage of the lesion was noted after the therapy for Kaposi sarcoma.

  19. Role of F-18 FDG PET/CT in the management of infected abdominal aortic aneurysm due to salmonella

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Seung Jin; Lee, Jin Soo; Cheong, Moon Hyun; Byun, Sung Su; Hyun, In Young [Inha University College of Medicine, Incheon (Korea, Republic of)

    2007-12-15

    We present a case of infected abdominal aortic aneurysm due to salmonella enteritidis. F-18 FDG PET/CT was performed to diagnosis and during follow-up after antibiotic treatment. Computed tomography (CT) is considered to be the best diagnostic imaging modality in infected aortic lesions. In this case, a combination of CT and FDG PET/CT provided accurate information for the diagnosis of infected abdominal aortic aneurysm. Moreover, FDG PET/CT made an important contribution of monitoring disease activity during antibiotic treatment.

  20. Response Assessment and Prediction in Esophageal Cancer Patients via F-18 FDG PET/CT Scans

    Science.gov (United States)

    Higgins, Kyle J.

    Purpose: The purpose of this study is to utilize F-18 FDG PET/CT scans to determine an indicator for the response of esophageal cancer patients during radiation therapy. There is a need for such an indicator since local failures are quite common in esophageal cancer patients despite modern treatment techniques. If an indicator is found, a patient's treatment strategy may be altered to possibly improve the outcome. This is investigated with various standard uptake volume (SUV) metrics along with image texture features. The metrics and features showing the most promise and indicating response are used in logistic regression analysis to find an equation for the prediction of response. Materials and Methods: 28 patients underwent F-18 FDG PET/CT scans prior to the start of radiation therapy (RT). A second PET/CT scan was administered following the delivery of ~32 Gray (Gy) of dose. A physician contoured gross tumor volume (GTV) was used to delineate a PET based GTV (GTV-pre-PET) based on a threshold of >40% and >20% of the maximum SUV value in the GTV. Deformable registration was used in VelocityAI software to register the pre-treatment and intra-treatment CT scans so that the GTV-pre-PET contours could be transferred from the pre to intra scans (GTV-intra-PET). The fractional decrease in the maximum, mean, volume to the highest intensity 10%-90%, and combination SUV metrics of the significant previous SUV metrics were compared to post-treatment pathologic response for an indication of response. Next for the >40% threshold, texture features based on a neighborhood gray-tone dimension matrix (NGTDM) were analyzed. The fractional decrease in coarseness, contrast, busyness, complexity, and texture strength were compared to the pathologic response of the patients. From these previous two types of analysis, SUV and texture features, the two most significant results were used in logistic regression analysis to find an equation to predict the probability of a non

  1. Comparison of diagnostic performance between interictal F-18-FDG PET and ictal Tc-99m-HMPAO SPECT in occipital lobe epilepsy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seok Ki; Lee, Dong Soo; Yeo, Jeong Seok; Lee, Sang Kun; Kim, Joo Yong; Jeong, Jae Min; Chung, June Key; Lee, Myung Chul [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of)

    1999-02-01

    Interictal F-18-fluorodeoxyglucose (FDG) PET and ictal Tc-99m-HMPAO SPECT are found to be useful in localizing epileptogenic zones in neocortical lateral temporal or frontal lobe epilepsy. We investigated whether interictal F-18-FDG PET or ictal Tc-99m-HMPAO SPECT was useful to find epileptogenic zones in occipital lobe epilepsy (OLE). We reviewed patterns of hypometabolism in interictal F-18 FDG PET and of hyperfusion in ictal Tc-99m-HMPAO SPECT in 17 OLE patients (mean age=27{+-}6.8 year, M : F=10:7, injection time =30{+-}17 sec). OLE was diagnosed based on invasive electroencephalography (EEG) study, surgery and post-surgical outcome (Engel class I in all for average 14 months). Epileptogenic zones were correctly localized in 9 (60%) out of 15 patients by interictal F-18-FDG PET. Epiletogenic hemispheres were correctly lateralized in 14 patients (93%) . By ictal Tc-99m-HMPAO SPECT, epileptogenic hemispheres were correctly lateralized in 13 patients (76%), but localization was possible only in 3 patients (18%). Among patients who showed no abnormality with MR imaging and no correct localization with ictal Tc-99m-HMPAO SPECT, interictal F-18-FDG PET was helpful in 2 patients. Ictal Tc-99m-HMPAO SPECT was helpful in lateralization but not in localization in OLE. Interictal F-18-FDG PET was helpful for localization of epileptogenic zones even in patients with ambiguous MR of ictal SPECT findings.

  2. Incidental tenosynovial huge cell tumors of the flexor hallucis longus muscle: seldom differential diagnosis of metabolic lesions using F18-FDG PET/CT; Inzidenteller tenosynovialer Riesenzelltumor des Musculus flexor hallucis longus. Seltene Differenzialdiagnose stoffwechselaktiver Laesionen in der F-18-FDG PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Koestner, W.; Daemmrich, M.; Derlin, T.

    2016-03-15

    Tenosynovial huge cell tumors are seldom benign tumors in extremities originating from bone joint synovia and tendon sheats. In F18-FDG PET/CT imaging the tenosynovial huge cell tumors show increased metabolic activity and can trigger false diagnoses.

  3. Evaluation of glucose metabolic abnormality in postlingually deaf patients using F-18-FDG positron emission tomography and statistical parametric mapping

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jae Sung; Lee, Dong Soo; Oh, Seung Ha; Kim, Chong Sun; Park, Kwang Suk; Chung, June Key; Lee, Myung Chul [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of)

    2000-07-01

    We have previously reported the prognostic relevance of cross-modal cortical plasticity in prelingual deaf patients revealed by F-18-FDG PET and SPM analysis. In this study, we investigated metabolic abnormality in postlingual deaf patients, whose clinical features are different from prelingual deafness. Nine postlingual deaf patients (age: 30.5 {+-}14.0) were performed on F-18-FDG brain PET. We compared their PET images with those of age-matched 20 normal controls (age: 27.1 {+-}8.6), and performed correlation analysis to investigate the relationship between glucose metabolism and deaf duration using SPM99. Glucose metabolism of deaf patients was significantly (p<0.05, corrected) decreased in both anterior cingulate, inferior frontal cortices, and superior temporal cortices, and left hippocampus. Metabolism in both superior temporal cortices and association area in inferior parietal cortices showed significant (p<0.01, uncorrected) positive correlation with deaf duration. Decreased metabolism in hippocampus accompanied with hypometabolism in auditory related areas can be explained by recent finding of anatomical connectivity between them, and may be the evidence indicating their functional connectivity. Metabolism recovery in auditory cortex after long deaf duration suggests that cortical plasticity takes place also in postlingual deafness.

  4. Possible additional value of 18FDG-PET in managing pancreas intraductal papillary mucinous neoplasms: Preliminary results

    Directory of Open Access Journals (Sweden)

    Pizzocaro Claudio

    2008-06-01

    Full Text Available Abstract Although some clinical and radiological features may predict malignancy presence in intraductal papillary mucinous pancreas neoplasms, preoperative diagnosis remains difficult. In this study we present 7 patients with Intraductal Papillary Mucinous Neoplasm (IPMN studied both with 18FDG-PET and magnetic resonance cholangiopancreatography (MRCP. A focal hypermetabolism was documented in 2 patients (the standardized uptake value in the neoplastic foci was 6.7 and 9, while absence of FDG uptake in the neoplasm area was recorded in the remaining 5 cases. Mean follow-up was 27 months (range 21–34. The final judgement was benign IPMN in 5 cases and malignant IPMN in 2. PET scan always correctly predicted the presence or absence of malignancy, while MRCP failed to detect malignancy in 3/7 cases. In conclusion, this preliminary experience suggests that 18FDG-PET may prove useful for malignancy detection in IPMN, improving differential diagnosis with benign intraductal papillary growth by functional data.

  5. Unexpected second primary malignancies detected by f-18 FDG PET/CT during follow-up for primary malignancy: Two case report

    Energy Technology Data Exchange (ETDEWEB)

    Bang, Ji In; Lee, Eun Seong; Kim, Tae Sung; Kim, Seok Ki [Nuclear Medicine, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of)

    2015-03-15

    As the survival rate of cancer patients has increased over the last few decades, the risk of cancer survivors developing second primary malignancies has gained attention. We report two rare cases of second primary hematologic malignancy detected by 18F-fluorodeoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) during follow-up for primary solid malignancies. Acute lymphoblastic leukemia developed in a breast cancer patient and non-Hodgkin lymphoma in an anal cancer patient. F-18 FDG PET/CT findings led to the diagnosis of unexpected second primary hematologic malignancy in cancer survivors in these two cases.

  6. Investigations on the effects of ``Ecstasy`` on cerebral glucose metabolism: an 18-FDG PET study; Untersuchungen zum Einfluss von ``Ecstasy`` auf den zerebralen Glukosemetabolismus: eine 18-FDG-PET-Studie

    Energy Technology Data Exchange (ETDEWEB)

    Schreckenberger, M.; Sabri, O.; Arning, C.; Tuttass, T.; Schulz, G.; Kaiser, H.J.; Wagenknecht, G.; Buell, U. [Klinik fuer Nuklearmedizin, Universitaetsklinik, RWTH Aachen (Germany); Gouzoulis-Mayfrank, E.; Sass, H. [Klinik fuer Psychiatrie, Universitaetsklinikum, RWTH Aachen (Germany)

    1998-12-31

    Purpose: The aim of the present study was to determine the acute effects of the `Ecstasy` analogue MDE (3,4-methylendioxyethamphetamine) on the cerebral glucose metabolism (rMRGlu) of healthy volunteers. Method: In a randomised double-blind trial, 16 healthy volunteers without a history of drug abuse were examined with 18-FDG PET 110-120 minutes after oral administration of 2 mg/kg MDE (n=8) or placebo (n=8). Beginning two minutes prior to radiotracer injection, a constant cognitive stimulation was maintained for 32 minutes using a word repetition paradigm in order to ensure constant and comparable mental conditions during cerebral 18-FDG uptake. Individual brain anatomy was represented using T1-weighted 3D flash MRI, followed by manual regionalisation into 108 regions-of-interest and PET/MRI overlay. Absolute quantification of rMRGlu and comparison of glucose metabolism under MDE versus placebo were performed using Mann-Whitney U-test. Results: Absolute global MRGlu was not significantly changed under MDE versus placebo (MDE: 41,8{+-}11,1 {mu}mol/min/100 g, placebo: 50,1{+-}18,1 {mu}mol/min/100 g, p=0,298). The normalised regional metabolic data showed a significantly decreased rMRGlu in the bilateral frontal cortex: Left frontal posterior (-7.1%, p<0.05) and right prefrontal superior (-4.6%, p<0.05). On the other hand, rMRGlu was significantly increased in the bilateral cerebellum (right: +10.1%, p<0.05; left: +7.6%, p<0.05) and in the right putamen (+6.2%, p<0.05). Conclusions: The present study revealed acute neurometabolic changes under the `Ecstasy` analogon MDE indicating a fronto-striato-cerebellar dysbalance with parallels to other psychotropic substances and various endogenous psychoses respectively. (orig.) [Deutsch] Ziel: In der vorliegenden Studie sollte die Akutwirkung des `Ecstasy`-Analogons MDE (3,4-Methylendioxyethamphetamin) auf den zentralen Glukosemetabolismus (rMRGlu) gesunder Probanden untersucht werden. Methode: In einer randomisierten

  7. Endometrial cancer with cervical extension mimicking dual concordant endometrial and cervical malignancy by F18 FDG PET and MRI

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Seok Nam [Kwandong Univ. College of Medicine, Seoul (Korea, Republic of)

    2012-09-15

    A 35 year old woman with endometrial cancer and cervical extension underwent F18 FDG PET CT and MRI studies after resection of a cervical mass presumed to be cervical myoma. The patient underwent cervical myomectomy and the histopathologic report revealed poorly differentiated invasive carcinoma. Cervical cancer was ruled out because the patient had no history of sexual intercourse and was negative for human papilloma virus infection. The patient underwent radical hysterectomy, bilateral salpingo oophorectomy, pelvic and para aortic lymph node dissection, and multiple biopsies. F18 FDG PET CT showed intense FDG uptake along the cervix wall. T2 weighted MRI also revealed a mass lesion with high SI involving the anterior and posterior lips of the uterine cervix. Another area of focal increased uptake above the endometrial lesion in the left pelvic cavity was observed on PET CT and MRI, possibly due to a functioning ovary. PET CT and MRI were interpreted as showing a dual concordant malignant lesion due to separated FDG uptakes and high SI without any connection between the cervical and endometrial lesions. F18 FDG PET CT showed intense FDG uptake along the endometrium. Given the patient's history and the fact that she was not menstruating at the time of imaging, this intense uptake was interpreted as another pathologic lesion, suggesting dual primary lesions. A suspected heterogeneous mass lesion along the endometrium suggesting concordant endometrial cancer was found on MRI. Endometrial cancer with cervical extension is sometimes difficult to differentiate from primary cervical cancer. The final histopathologic report showed poorly differentiated endometrial adenocarcinoma with cervical extension, although the FDG PET CT and MRI findings were suggestive of concordant cervical and endometrial cancer. Although histopathologic confirmation is necessary for final diagnosis, MRI and FDG PET CT studies may aid in the differential diagnosis. A metastatic cervical mass

  8. Pretreatment F-18 FDG PET/CT Parameters to Evaluate Progression-Free Survival in Gastric Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jeonghun; Lim, Seok Tae; Na, Chang Ju; Han, Yeonhee; Kim, Chanyoung; Jeong, Hwanjeong; Sohn, Myunghee [Chonbuk National Univ., Jeonju (Korea, Republic of)

    2014-03-15

    We performed this study to evaluate the predictive value of pretreatment F-18 FDG PET/CT for progression-free survival (PFS) in patients with gastric cancer. Of 321 patients with a diagnosis of gastric cancer, we retrospectively enrolled 97 patients (men:women = 61:36, age 59.8±13.2 years), who underwent pretreatment F-18 fluoro-2-deoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) from January 2009 to December 2009. Maximum standardized uptake value (SUVmax) was measured for each case with detectable primary lesions. In the remaining non-detectable cases, SUVmax was measured from the corresponding site seen on gastroduodenoscopy for analysis. In subgroup analysis, metabolic tumor volume (MTV) was measured in 50 patients with clearly distinguishable primary lesions. SUVmax, stage, depth of tumor invasion and presence of lymph node metastasis were analyzed in terms of PFS. Receiver operating characteristic (ROC) curves were used to find optimal cutoff values of SUVmax and MTV for disease progression. The relationship between SUVmax, MTV and PFS was analyzed using the Kaplan-Meier with log-rank test and Cox's proportional hazard regression methods. Of 97 patients, 15 (15.5 %) had disease progression. The mean follow-up duration was 29.6±10.2 months. The mean PFS of low SUVmax group (≤5.74) was significantly longer than that of the high SUVmax group (>5.74) (30.9±8.0 vs 24.3±13.6 months, p =0.008). In univariate analysis, stage (I vs II, III, IV), depth of tumor invasion (T1 vs T2, T3, T4), presence of lymph node metastasis and SUVmax (>5.74 vs ≤5.74) were significantly associated with recurrence. In multivariate analysis, high SUVmax (>5.74) was the only poor prognostic factor for PFS (p =0.002, HR 11.03, 95% CI 2.48.49.05). Subgroup multivariate analysis revealed that high MTV (>16.42) was the only poor prognostic factor for PFS (p =0.034, HR 3.59, 95 % CI 1.10.11.71). In gastric cancer, SUVmax measured by pretreatment F-18

  9. Monitoring of Tumor Response to Neoadjuvant Radio-Chemotherapy of Esophageal Carcinoma by F-18-FDG-PET%F-18-FDG-PET监测新辅助疗法食管癌的反应

    Institute of Scientific and Technical Information of China (English)

    Peter Theissen; Paul M.Schneider; Stephan E.Baldus; Alexandra Jost; Markus Dietlein; Rolf P.Müller; Arnulf H.H(o)lscher; Harald Schicha

    2004-01-01

    Introduction: For clinical assessment of neoadjuvant radiochemotherapy of esophageal cancer reliable in-vivo methods are necessary. Therefore, the capabilities of F-18-Fluorodesoxyglucose-PET in comparison to histomorphological grading of tumor regression were studied. Methods: In 33 patients with locally advanced esophageal carcinoma (uT3, uN0-1, cM0) F-18-FDG-PET was performed before and 2weeks after radiochemotherapy. All tumors were resected by transthoracic en-bloc esophagectomy 3-4 weeks after induction therapy. A subgroup of 11 patients underwent weekly PET scan during neoadjuvant therapy.PET was performed in a dedicated scanner 1.3 h after administration of 370 MBq F-18-FDG. Data analysis based on maximum SUV data derived from individual regions of interest in pre- and posttherapeutic images. PET data were compared to histomorphological grading parameters for tumor regression whithin the resected tissues. Results: The comparison of histopathological tumor regression after neoadjuvant therapy and PET SUV differences showed a significant X2 P-value of 0.006. There was a significant decrease of the SUV data from 9.1±3.5 to 4.3±1.9 (P<0.0001). In therapy responders SUV was diminished by 59% and in non-responders by 34 %. Longitudinal SUV measurement during neoadjuvant therapy showed a strong SUV decrease already after one and two weeks (P=-0.021 and 0.003). Conclusion: The recent data of the FDG-PET follow-up after neoadjuvant therapy show that PET is able to predict therapy response.Longitudinal PET data advocate that it may be possible to recognize response also very early during radiochemotherapy.

  10. Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging

    Directory of Open Access Journals (Sweden)

    Grills Inga

    2007-05-01

    Full Text Available Abstract Background To correlate the metabolic changes with size changes for tumor response by concomitant PET-CT evaluation of lung cancers after radiotherapy. Methods 36 patients were studied pre- and post-radiotherapy with18FDG PET-CT scans at a median interval of 71 days. All of the patients were followed clinically and radiographically after a mean period of 342 days for assessment of local control or failure rates. Change in size (sum of maximum orthogonal diameters was correlated with that of maximum standard uptake value (SUV of the primary lung cancer before and after conventional radiotherapy. Results There was a significant reduction in both SUV and size of the primary cancer after radiotherapy (p Conclusion Correlating and incorporating metabolic change by PET into size change by concomitant CT is more sensitive in assessing therapeutic response than CT alone.

  11. {sup 18}FDG PET and acetazolamide-enhanced {sup 99m}Tc-HMPAO SPET in systemic lupus erythematosus

    Energy Technology Data Exchange (ETDEWEB)

    Gruenwald, F. [Bonn Univ. (Germany). Inst. fuer Klinische und Experimentelle Nuklearmedizin; Schomburg, A. [Bonn Univ. (Germany). Inst. fuer Klinische und Experimentelle Nuklearmedizin; Badali, A. [Dept. of Dermatology, Univ. of Bonn (Germany); Ruhlmann, J. [Bonn Univ. (Germany). Inst. fuer Klinische und Experimentelle Nuklearmedizin; Pavics, L. [Bonn Univ. (Germany). Inst. fuer Klinische und Experimentelle Nuklearmedizin; Biersack, H.J. [Bonn Univ. (Germany). Inst. fuer Klinische und Experimentelle Nuklearmedizin

    1995-09-01

    In this report, we present the case of a 70-year-old female patient, suffering from SLE without symptoms of CNS involvement. In addition to a SPET study using technetium-99m hexamethylpropylene amine oxime ({sup 99m}Tc-HMPAO) and a PET scan with fluorine-18 deoxyglucose ({sup 18}FDG), a SPET study after acetazolamide injection was performed in order to assess the cerebral perfusion reserve. While the PET scan showed no major abnormalities, and the baseline SPET study revealed only minor changes, the acetazolamide-enhanced SPET study revealed a marked reduction of the cortical perfusion reserve, particularly in both frontal lobes. It is concluded that ``preclinical`` CNS involvement, mainly caused by pathological mechanisms involving the cerebral blood vessels, can be considered to exist in this patient with SLE. (orig.). With 2 figs.

  12. Monitoring of Tumor Response to Neoadjuvant Radio-Chemotherapy of Esophageal Carcinoma by F-18-FDG-PET

    Institute of Scientific and Technical Information of China (English)

    PeterTheissen; PaulM.Schneider; StephanE.Baldus; AlexandraJost; MarkusDietlein; RolfP.Miiller; ArnulfH.Hoelscher; HaraldSchicha

    2004-01-01

    Introduction: For clinical assessment of neoadjuvant radiochemotherapy of esophageal cancer reliable in-vivo methods are necessary. Therefore, the capabilities of F-18-Fluorodesoxyglucose-PET in comparison to histomorphological grading of tumor regression were studied. Methods: In 33 patients with locally advanced esophageal carcinoma (uT3, uN0-1, cM0) F-18-FDG-PET was performed before and 2 weeks after radiochemotherapy. All tumors were resected by transthoracic en-bloc esophagectomy 3-4 weeks after induction therapy. A subgroup of 11 patients underwent weekly PET scan during neoadjuvant therapy.PET was performed in a dedicated scanner 1.3 h after administration of 370 MBq F-18-FDG. Data analysis based on maximum SUV data derived from individual regions of interest in pre- and posttherapeutic images. PET data were compared to histomorphological grading parameters for tumor regression whithin the resected tissues. Results: The comparison of histopathological tumor regression after neoadjuvant therapy and PET SUV differences showed a significant x2 P-value of 0.006. There was a significant decrease of the SUV data from 9.14-3.5 to 4.3±1.9 (P<0.0001). In therapy responders SUV was diminished by 59% and in non-responders by 34 %. Longitudinal SUV measurement during neoadjuvant therapy showed a strong SUV decrease already after one and two weeks (P=0.021 and 0.003). Conclusion: The recent data of the FDG-PET follow-up after neoadjuvant therapy show that PET is able to predict therapy response.Longitudinal PET data advocate that it may be possible to recognize response also very early during radiochemotherapy.

  13. Normal physiologic and Benign foci with F-18 FDG avidity on PET/CT in patients with breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Park, Soon Ah; Lee, Kwang Man; Choi, Un Jong; Kim, Hun Soo; Kim, Hye Won; Song, Jeong Hoon [College of Medicine, Wonkwnag University, Iksan (Korea, Republic of)

    2010-12-15

    The aim of this study was to evaluate the physiologic and benign F-18 fluorodeoxyglucose (FDG) avid foci in patients with breast cancer. On 309 F-18 FDG PET/CT scans of 241 women with breast cancer, the hypermetabolic lesions compared with the surrounding normal region were evaluated retrospectively. Available reports of other relevant radiological imaging medical records, and follow-up PET/CT were reviewed for explanations of the abnormal uptake. Among the 70 physiologic foci, muscular uptake of the lower neck following the surgical and/or radiation therapy of ipsilateral breast (29%), hypermetabolic ovaries (16%) and uterine (10%) uptake during the ovulatory and menstrual phases during the normal menstrual cycle were identified, and also hypermetabolic brown fat in cold-induced thermogenesis (7%), non-specific bowel uptake (35%) were observed. Among the 147 benign lesions, sequelae of the chest wall and breasts following surgical and/or radiation therapy, were often observed (27%). Hypermetabolic thyroid glands were noted as adenomas and chronic thyroiditis (18%). Reactive hyperplasia of cervical or mediastinal lymph nodes (32%), degenerative osteoarthritis and healed fractures (15%), hypermetabolic benign lung lesions (6%) were observed. Altered physiologic and benign F-18 FDG uptake in the cervical muscle and chest wall following ipsilateral breast surgery or radiotherapy were common, and also normal physiologic uptake in ovary and uterus, brown fat, thyroid were considered as predominant findings in women patients with breast cancer. Knowledge of these findings might aid in the interpretation of FDG PET/CT in patients with breast cancer

  14. Evaluation of Response to Therapy in a Patient with Lung Cancer: Correlation of Sclerotic Bone Lesions with F 18 FDG PET/CT and Bone Scintigraphy

    Directory of Open Access Journals (Sweden)

    Filiz Özülker

    2011-04-01

    Full Text Available A 64-year-old male patient with small cell lung cancer underwent Fluorine-18 fluorodeoxyglucose (F 18 FDG positron emission tomography (PET/CT scan which revealed multiple F 18 FDG uptake in the spine, both humeri, ribs, pelvis and proximal long bones. There was no obvious lytic or sclerotic bone destruction accompanying these lesions on CT component of the study. After the patient received six courses of chemotherapy a repeat F 18 FDG-PET/CT was performed for evaluation of therapy response. The PET/CT showed the presence of multiple sclerotic lesions on CT without FDG uptake, corresponding to the bone lesions on the previous PET/CT scan. A concomitant Tc 99m Methylene diphosphonate (Tc 99m MDP bone scintigraphy (BS revealed no pathologically increased Tc 99m MDP uptake in the skeletal system. The FDG avid lesions in the skeletal system, which were not sclerotic initially, were transformed into FDG non-avid sclerotic lesions after chemotherapy. This was attributed to the direct effect of previous successful therapy for bone metastases, leading to the transformation of metabolically active disease, into blastic metabolically inactive metastases. In conclusion, a F 18 FDG negative bone lesion, which is sclerotic on CT, may represent post-treatment osteoblastic change rather than active tumor and BS might play a role in the discrimination of these two situations. (MIRT 2011; 20: 29-33

  15. A Randomised Controlled Trial Assessing the Effect of Oral Diazepam on F-18-FDG Uptake in the Neck and Upper Chest Region

    NARCIS (Netherlands)

    Sturkenboom, M.G.G.; Hoekstra, O.S.; Postema, E.J.; Zijlstra-Baalbergen, J.M.; Berkhof, J.; Franssen, E.J.F.

    2009-01-01

    A distinctive pattern of physiological symmetrical uptake of F-18-fluorodeoxyglucose (F-18-FDG) in the neck and upper chest region is a phenomenon that is sometimes observed on positron emission tomography (PET) scans of some oncologic patients. Initially, it was assumed to be muscle uptake secondar

  16. Multiple skeletal muscle metastases in a case of transitional cell carcinoma of bladder detected by F-18 FDG PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Kashyap, Raghava; Mittal, Bhagwant Rai; Chakraborty, Dhritiman; Bhattacharya, Anish; Singh, Baljinder [Institute of Medical Education and Research, Chandigarh (India)

    2010-12-15

    We present a case of poorly differentiated muscle invasive transitional cell carcinoma in a 64-year-old male diagnosed with FDG-avid mass in the urinary bladder wall and multiple skeletal muscles visualised on F-18 FDG PET/CT

  17. Trabectedin in Advanced High-Grade Uterine Leiomyosarcoma: A Case Report Illustrating the Value of18FDG-PET-CT in Assessing Treatment Response

    Directory of Open Access Journals (Sweden)

    M.J. Payne

    2014-02-01

    Full Text Available We report the case of a 60-year-old woman with metastatic high-grade uterine leiomyosarcoma who achieved a delayed response to second-line therapy with the marine-derived drug trabectedin (Yondelis®, PharmaMar. We used 2-deoxy-2-[18F] fluorodeoxyglucose (FDG-positron emission tomography (PET-CT imaging as a tool for response monitoring in parallel with conventional re-staging according to Response Evaluation Criteria in Solid Tumours (RECIST using computed tomography (CT. We illustrate the role of serial 18FDG-PET-CT imaging in the functional assessment of tumour response. Three cycles after commencement of trabectedin treatment, a reduction of the maximum standardized uptake value (SUVmax of the solid component of the pelvic mass was observed, indicating a cystic or necrotic response in the tumour to trabectedin. After 7 cycles of treatment, on 18FDG-PET-CT there was clear evidence of ongoing disease improvement: the solid pelvic components were at worst stable, with an unchanged SUVmax, and possibly marginally reduced in size, while the pulmonary metastases had further reduced in size and become FDG negative; the bony metastases were stable. After a total of 13 cycles of treatment, administered over 13 months, the patient showed signs of progression on an 18FDG-PET-CT scan. The safety profile of trabectedin remained manageable, showing no evidence of cumulative toxicity and being associated with a preserved quality of life. This report illustrates potential limitations of RECIST in response assessments and the critical role of serial 18FDG-PET-CT imaging in assessing response to trabectedin treatment. Therefore, we propose that 18FDG-PET-CT may improve the assessment of response to trabectedin in selected patients.

  18. Epileptic patterns of local cerebral metabolism and perfusion in man determined by emission computed tomography of /sup 18/FDG and /sup 13/NH/sub 3/

    Energy Technology Data Exchange (ETDEWEB)

    Kuhl, D.E.; Engel, J. Jr.; Phelps, M.E.; Selin, C.

    1979-01-01

    Seventeen patients with partial epilepsy had EEG monitoring concurrent with cerebral emission computed tomography (ECT) after /sup 18/F-fluorodeoxyglucose (/sup 18/FDG) and /sup 13/N-ammonia were given intravenously as indicators of local cerebral glucose utilization (LCMR/sub glc/) and relative perfusion, respectively. In 12 of 15 patients who had unilateral or focal electrical abnormalities, interictal /sup 18/FDG scan patterns clearly showed localized regions of decreased (20% to 50%) LCMR/sub glc/, which correlated anatomically with the eventual EEG localization. These hypometabolic zones appeared normal on x-ray computed tomography in all but three patients and were unchanged on scans repeated on different days. In 5 of 6 patients who underwent temporal lobectomy, the interictal /sup 18/FDG scan correctly detected the pathologically confirmed lesion as a hypometabolic zone, and removal of the lesion site resulted in marked clinical improvement. In contrast, the ictal /sup 18/FDG scan patterns clearly showed foci of increased (82% to 130%) LCMR/sub glc/, which correlated temporally and anatomically with ictal EEG spike foci and were within the zones of interictal hypometabolism (3 studies in 2 patients). /sup 13/NH/sub 3/ distributions paralleled /sup 18/FDG increases and decreases in abnormal zones, but /sup 13/NH/sub 3/ differences were of lesser magnitude. When the relationship of /sup 13/NH/sub 3/ uptake to local blood flow found in dog brain was applied as a correction to the patients' /sup 13/NH/sub 3/ scan data, local alterations in perfusion and glucose utilization were usually matched, both in the interictal and ictal states.

  19. Diagnostic Performance of F-18 FDG PET/CT in Patients with Cancer of Unknown Primary: Additional Benefit over CT-Based Conventional Work up

    Directory of Open Access Journals (Sweden)

    Mehrdad Bakhshayeshkaram

    2016-01-01

    Full Text Available Background: In the era of well-developed site-specific treatment strategies in cancer, identification of occult primary is of paramount importance in CUP patients. Furthermore, exact determination of the extent of the disease may help in optimizing treatment planning. The aim of the present study was to investigate additional value of F-18 FDG PET/CT in patients with cancer of unknown primary (CUP as an appropriate imaging tool in early phase of initial standard work up.Materials and Methods: Sixty-two newly diagnosed CUP patients with inconclusive diagnostic CT scan of chest, abdomen and pelvis referring for F-18 FDG PET/CT were enrolled in this study. Standard of reference was defined as histopathology, other diagnostic procedures and a 3-month formal clinical follow up. The results of PET/CT were categorized as suggestion for primary site and additional metastasis and classified as true positive, false positive, false negative and true negative. The impact of additional metastasis revealed by F-18 FDG PET/CT on treatment planning and the time contribution of F-18 FDG PET/CT in diagnostic pathway was investigated.Results: Sixty-two patients with mean age of 62 (30 men, 32 women, PET/CT correctly identified primary origin in 32% with false positive rate of 14.8%. No primary lesion was detected after negative PET/CT according to standard of reference. Sensitivity, Specificity and accuracy were 100%, 78% and 85%, respectively. Additional metastatic site was found in 56% with 22% impact on treatment planning. Time contribution for PET/CT was 10% of total diagnostic pathway.Conclusion: Providing higher detection rate of primary origin with excellent diagnostic performance, shortening the diagnostic pathway and improving treatment planning, F-18 FDG PET/CT may play a major role in diagnostic work up of CUP patients and may be recommended as an alternative imaging tool in early phase of investigation.

  20. 18FDG PET/CT in therapeutic assessment and prognostic of non-small cell lung cancer%18FDG PET/CT在非小细胞肺癌疗效评估及预后的价值

    Institute of Scientific and Technical Information of China (English)

    吴颖; 宋勇; 施毅

    2008-01-01

    PET/CT实现了CT解剖结构与PET代谢信息的融合,提高了肺癌诊断的敏感性及特异性,已经广泛用于肺癌的TNM分期.越来越多研究显示它在评估肺癌化放疗疗效及判断预后也有应用前景.目前研究示18FDG PET/CT可以早期准确评估肺癌患者化放疗后疗效,但PET机型,疗效评估最佳时间及评价标准尚未统一.回顾性研究提示原发肿瘤的标准摄取值(standard uptake value,SUV)可能是肿瘤生物侵袭性的预后因子,但需大样本的前瞻性研究证实,并探讨其潜在细胞机制及确定其作为预后的18FDG摄取阈值.

  1. Semi-Quantitative Calculations of Primary Tumor Metabolic Activity Using F-18 FDG PET/CT as a Predictor of Survival in 92 Patients With High-Grade Bone or Soft Tissue Sarcoma

    DEFF Research Database (Denmark)

    Andersen, Kim Francis; Fuglo, Hanna Maria; Rasmussen, Sine Hvid;

    2015-01-01

    To assess the prognostic value of primary tumor metabolic activity in patients with high-grade bone sarcomas (BS) or soft tissue sarcomas (STS) using F-18 FDG PET/CT. A single-site, retrospective study including 92 patients with high-grade BS or STS. Pretreatment F-18 FDG PET/CT scan was performed...... metabolic activity with pretherapeutic SUVmax using F-18 FDG PET/CT demonstrates independent properties beyond histologic grading for prediction of survival in patients with high-grade STS, but not with high-grade BS....

  2. Implications of Pericardial, Visceral and Subcutaneous Adipose Tissue on Vascular Inflammation Measured Using 18FDG-PET/CT.

    Directory of Open Access Journals (Sweden)

    Ho Cheol Hong

    Full Text Available Pericardial adipose tissue (PAT is associated with adverse cardiometabolic risk factors and cardiovascular disease (CVD. However, the relative implications of PAT, abdominal visceral and subcutaneous adipose tissue on vascular inflammation have not been explored.We compared the association of PAT, abdominal visceral fat area (VFA, and subcutaneous fat area (SFA with vascular inflammation, represented as the target-to-background ratio (TBR, the blood-normalized standardized uptake value measured using 18F-Fluorodeoxyglucose Positron Emission Tomography (18FDG-PET in 93 men and women without diabetes or CVD. Age- and sex-adjusted correlation analysis showed that PAT, VFA, and SFA were positively associated with most cardiometabolic risk factors, including systolic blood pressure, LDL-cholesterol, triglycerides, glucose, insulin resistance and high sensitive C-reactive proteins (hsCRP, whereas they were negatively associated with HDL-cholesterol. In particular, the maximum TBR (maxTBR values were positively correlated with PAT and VFA (r = 0.48 and r = 0.45, respectively; both P <0.001, whereas SFA showed a relatively weak positive relationship with maxTBR level (r = 0.31, P = 0.003.This study demonstrated that both PAT and VFA are significantly and similarly associated with vascular inflammation and various cardiometabolic risk profiles.

  3. Diagnosis of bone metastases: a meta-analysis comparing {sup 18}FDG PET, CT, MRI and bone scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Hui-Lin; Liu, Tao [Hospital of Soochow University, Department of Orthopaedics, Suzhou (China); Wang, Xi-Ming [Hospital of Soochow University, Department of Radiology, Suzhou (China); Xu, Yong [Public Health School of Soochow University, Department of Epidemiology and Biostatistics, Suzhou (China); Deng, Sheng-Ming [Department of Nuclear Medicine, The first affiliated hospital of Soochow University, Suzhou (China)

    2011-12-15

    To perform a meta-analysis to compare {sup 18}FDG PET, CT, MRI and bone scintigraphy (BS) for the diagnosis of bone metastases. Databases including MEDLINE and EMBASE were searched for relevant original articles published from January 1995 to January 2010. Software was used to obtain pooled estimates of sensitivity, specificity and summary receiver operating characteristic curves (SROC). 67 articles consisting of 145 studies fulfilled all inclusion criteria. On per-patient basis, the pooled sensitivity estimates for PET, CT, MRI and BS were 89.7%, 72.9%, 90.6% and 86.0% respectively. PET=MRI>BS>CT. (''=''indicated no significant difference, P > 0.05; ''>'' indicated significantly higher, P < 0.05). The pooled specificity estimates for PET, CT, MRI and BS were 96.8%, 94.8%, 95.4% and 81.4% respectively. PET = CT = MRI>BS. On per-lesion basis, the pooled sensitivity estimates for PET, CT, MRI and BS were 86.9%, 77.1%, 90.4% and 75.1% respectively. PET = MRI>BS>CT. The pooled specificity estimates for PET, CT, MRI and BS were 97.0%, 83.2%, 96.0% and 93.6% respectively. PET>MRI>BS>CT. PET and MRI were found to be comparable and both significantly more accurate than CT and BS for the diagnosis of bone metastases. (orig.)

  4. Malignant extrarenal rhabdoid tumor of the spine: staging and evaluation of response to therapy with F-18 FDG PET/CT.

    Science.gov (United States)

    Makis, William; Ciarallo, Anthony; Hickeson, Marc

    2011-07-01

    Malignant extrarenal rhabdoid tumor (ERRT) is a very rare type of soft-tissue sarcoma with a reported incidence of 0.3% of all soft-tissue sarcomas. Only 7 cases of spinal malignant ERRT have been reported in the literature, and to our knowledge, F-18 FDG PET/CT imaging for staging and evaluation of response to therapy for these tumors has not been previously described. This is a case of an 8-month-old boy with malignant ERRT of the spine, who was staged with F-18 FDG PET/CT, and had his tumor burden assessed with PET/CT after chemotherapy, which altered the subsequent chemotherapy regimen.

  5. Isolated thymic Langerhans cell histiocytosis discovered on F-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT)

    Energy Technology Data Exchange (ETDEWEB)

    Turpin, Sophie [CHU Sainte-Justine, Nuclear Medicine, Montreal (Canada); Carret, Anne-Sophie [CHU Sainte-Justine, Hemato-Oncology, Montreal (Canada); Dubois, Josee [CHU Sainte-Justine, Radiology, Montreal (Canada); Buteau, Chantal [CHU Sainte-Justine, Infectious Diseases, Montreal (Canada); Patey, Natalie [CHU Sainte-Justine, Pathology, Montreal (Canada)

    2015-11-15

    The thymic infiltration in young patients with multisystemic Langerhans cell histiocytosis and its radiologic features are well known. However, isolated thymic disease has seldom been reported in the literature. We report the case of a 10-month-old child admitted for fever of unknown origin. Whole-body F-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) was performed to identify a focus of infection. It demonstrated an unusual aspect of the thymus, which led to further investigation and revealed isolated infiltration of the thymus by Langerhans cell histiocytosis. The patient was treated accordingly and is now disease free. As evaluation of Langerhans cell histiocytosis patients with F-18 FDG PET/CT is becoming more frequent, it is important to be aware of the scintigraphical characteristics of thymic Langerhans cell histiocytosis. (orig.)

  6. Diffuse pulmonary metastases with negative 18FDG positron emission tomography/computed tomography and positive post-radioiodine therapy scan of papillary thyroid cancer

    Institute of Scientific and Technical Information of China (English)

    LIN Yan-song; LIANG Zhi-yong; QIU Li-heng; CHENG Xin

    2012-01-01

    A female papillary thyroid cancer patient with diffuse micronodular pulmonary metastases was confirmed only by post radioactive iodine (RAI) therapy whole body scan (RxWBS).Her diagnostic iodine-131 whole body scan (DxWBS),chestCT and 18FDG PET/CT scan were all negative.Attention and pitfalls of this case concerning surgical and RAI dosemanagement are against current international guidelines on thyroid cancer.

  7. The Effect of Patient Age on Standardized Uptake Value-Hounsfield Unit Values of Male Genitourinery Structures In F-18 FDG PET/CT

    Directory of Open Access Journals (Sweden)

    Berrin Çavuşoğlu

    2011-12-01

    Full Text Available Objective: Relation between patient age and Hounsfield Unit (HU,which is the linear attenuation coefficient, and Standardized Uptake Values (SUV which is the amount of 18F-fluorodeoxyglucose (F-18 FDG uptake, measured in the areas of interest drawn to prostate, seminal vesicles and testicles in F-18 FDG Positron Emission Tomography/Computed Tomography (PET/CT images was investigated. Material and Methods: Mean and maximum SUV and HU values were recorded from the areas of interest (min 12 mm in diameter which showed FDG uptake in prostate, seminal vesicles and testicles from F-18 FDG PET-CT images of 21 male patients under 40 years without genitourinary cancer. The effect of patient age to SUV and HU values was examined with Pearson correlation test using SPSS program. Results: There was a negative insignificant correlation between patient age and SUV and HU values for prostate. For seminal vesicles, correlation between patient age and SUV values and HUmax were positive but insignificant, while correlation with HUmean was significant (r=0.459, p=0.00. Correlation between patient age and SUVmax and SUVmean values were significant for testicles (r=0.506, p=0.002 and r=0.467, p=0.005, respectively but the correlation between patient age and HUmax and HUmean values was not significant. Conclusion: F-18 FDG uptake in testicles in males increases with age until 40, suggesting an increase in metabolic rate. The significant correlation between age and mean HU values is probably caused by thickening of the tissue without an increase in glucose metabolism in seminal vesicles. In prostate, the effect of patient age to SUV and HU values was not observed until the age 40. (MIRT 2011;20:104-107

  8. 64Cu-ATSM and 18FDG PET uptake and 64Cu-ATSM autoradiography in spontaneous canine tumors: comparison with pimonidazole hypoxia immunohistochemistry

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    Hansen Anders E

    2012-06-01

    Full Text Available Abstract Background The aim of this study was to compare 64Cu-diacetyl-bis(N4-methylsemicarbazone (64Cu-ATSM and 18FDG PET uptake characteristics and 64Cu-ATSM autoradiography to pimonidazole immunohistochemistry in spontaneous canine sarcomas and carcinomas. Methods Biopsies were collected from individual tumors between approximately 3 and 25 hours after the intravenous injection of 64Cu-ATSM and pimonidazole. 64Cu-ATSM autoradiography and pimonidazole immunostaining was performed on sectioned biopsies. Acquired 64Cu-ATSM autoradiography and pimonidazole images were rescaled, aligned and their distribution patterns compared. 64Cu-ATSM and 18FDG PET/CT scans were performed in a concurrent study and uptake characteristics were obtained for tumors where available. Results Maximum pimonidazole pixel value and mean pimonidazole labeled fraction was found to be strongly correlated to 18FDG PET uptake levels, whereas more varying results were obtained for the comparison to 64Cu-ATSM. In the case of the latter, uptake at scans performed 3 h post injection (pi generally showed strong positive correlated to pimonidazole uptake. Comparison of distribution patterns of pimonidazole immunohistochemistry and 64Cu-ATSM autoradiography yielded varying results. Significant positive correlations were mainly found in sections displaying a heterogeneous distribution of tracers. Conclusions Tumors with high levels of pimonidazole staining generally displayed high uptake of 18FDG and 64Cu-ATSM (3 h pi.. Similar regional distribution of 64Cu-ATSM and pimonidazole was observed in most heterogeneous tumor regions. However, tumor and hypoxia level dependent differences may exist with regard to the hypoxia specificity of 64Cu-ATSM in canine tumors.

  9. (18)F and (18)FDG PET imaging of osteosarcoma to non-invasively monitor in situ changes in cellular proliferation and bone differentiation upon MYC inactivation.

    Science.gov (United States)

    Arvanitis, Constadina; Bendapudi, Pavan K; Tseng, Jeffrey R; Gambhir, Sanjiv Sam; Felsher, Dean W

    2008-12-01

    Osteosarcoma is one of the most common pediatric cancers. Accurate imaging of osteosarcoma is important for proper clinical staging of the disease and monitoring of the tumor's response to therapy. The MYC oncogene has been commonly implicated in the pathogenesis of human osteosarcoma. Previously, we have described a conditional transgenic mouse model of MYC-induced osteosarcoma. These tumors are highly invasive and are frequently associated with pulmonary metastases. In our model, upon MYC inactivation osteosarcomas lose their neoplastic properties, undergo proliferative arrest and differentiate into mature bone. We reasoned that we could use our model system to develop noninvasive imaging modalities to interrogate the consequences of MYC inactivation on tumor cell biology in situ. We performed positron emission tomography (PET) combining the use of both (18)F-fluorodeoxyglucose ((18)FDG) and (18)F-flouride ((18)F) to detect metabolic activity and bone mineralization/remodeling. We found that upon MYC inactivation, tumors exhibited a slight reduction in uptake of (18)FDG and a significant increase in the uptake of (18)F along with associated histological changes. Thus, these cells have apparently lost their neoplastic properties based upon both examination of their histology and biologic activity. However, these tumors continue to accumulate (18)FDG at levels significantly elevated compared to normal bone. Therefore, PET can be used to distinguish normal bone cells from tumors that have undergone differentiation upon oncogene inactivation. In addition, we found that (18)F is a highly sensitive tracer for detection of pulmonary metastasis. Collectively, we conclude that combined modality PET/CT imaging incorporating both (18)FDG and (18)F is a highly sensitive means to non-invasively measure osteosarcoma growth and the therapeutic response, as well as to detect tumor cells that have undergone differentiation upon oncogene inactivation.

  10. The role of 18FDG, 18FDOPA PET/CT and 99mTc bone scintigraphy imaging in Erdheim-Chester disease.

    Science.gov (United States)

    García-Gómez, F J; Acevedo-Báñez, I; Martínez-Castillo, R; Tirado-Hospital, J L; Cuenca-Cuenca, J I; Pachón-Garrudo, V M; Álvarez-Pérez, R M; García-Jiménez, R; Rivas-Infante, E; García-Morillo, J S; Borrego-Dorado, I

    2015-08-01

    Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocitosis, characterized by multisystemic xanthogranulomatous infiltration by foamy histiocytes that stain positively for CD68 marker but not express CD1a and S100 proteins. Etiology and pathogenesis are still unknown and only about 500 cases are related in the literature. Multisystemic involvement leads to a wide variety of clinical manifestations that results in a poor prognosis although recent advances in treatment. We present the clinical, nuclear medicine findings and therapeutic aspects of a serie of 6 patients with histopathological diagnosis of ECD, who have undergone both bone scintigraphy (BS) and 18F-fluorodeoxyglucose (18FDG)-PET/CT scans in our institution. A complementary 18F-fluorodopa (18FDOPA)-PET/CT was performed in one case. Three different presentations of the disease were observed in our casuistic: most indolent form was a cutaneous confined disease, presented in only one patient. Multifocal involvement with central nervous system (CNS) preservation was observed in two patients. Most aggressive form consisted in a systemic involvement with CNS infiltration, presented in three patients. In our experience neurological involvement, among one case with isolate pituitary infiltration, was associated with mortality in all cases. 18FDG-PET/CT and BS were particularly useful in despite systemic involvement; locate the site for biopsy and the treatment response evaluation. By our knowledge, 18FDOPA-PET/CT not seems useful in the initial staging of ECD. A baseline 18FDG-PET/CT and BS may help in monitoring the disease and could be considered when patients were incidentally diagnosed and periodically 18FDG-PET/CT must be performed in the follow up to evaluate treatment response.

  11. Clinical Usefulness of F-18 FDG PET/CT in papillary thyroid cancer with negative radioiodine scan and elevated thyroglobulin level or positive anti-thyroglobulin antibody

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Su Jung; Jung, Kyung Pyo; Lee, Sun Seong; Park, Yun Soo; Lee, Seok Mo [Dept. of Nuclear Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan (Korea, Republic of); Bae, Sang Kyun [Dept. of Nuclear Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan (Korea, Republic of)

    2016-06-15

    Elevated thyroglobulin (Tg) levels, along with a negative radioiodine scan, present a clinical problem for the diagnosis of recurrence in papillary thyroid cancer (PTC) patients. The purpose of this study was to assess (1) the usefulness of 18F-fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET)/computed tomography (CT) for PTC patients with negative diagnostic radioiodine scan and elevated serum Tg level or positive anti-thyroglobulin antibody (TgAb), and (2) the effect of endogenous thyroid stimulating hormone (TSH) stimulation (ETS) on detecting recurrence in these circumstances. Eighty-four patients with negative diagnostic radioiodine scan and elevated serum Tg or positive TgAb under ETS were included. Correlation with clinicopathological features and recurrence, detectability of FDG PET/CT and cut-off value of serum Tg for recurrence in PTC patients with these circumstance were assessed. In addition, detectability of F-18 FDG PET/CT under ETS and suppression were compared. In Cox regression analysis, only serum Tg level was significantly associated with recurrence (P<0.001, HR  = 1.13; 95 % CI, 1.061–1.208). The cut-off level of Tg was 21.5 ng/mL (AUC, 0.919; P < 0.001) for discriminating the recurrence in the patients with positive PET/CT finding. The sensitivity, specificity, PPV, NPV, and accuracy of F-18 FDG PET/CT for detecting recurrence were 64 %, 94 %, 86 %, 81 %, and 83 %. In the analysis of F-18 FDG PET/CT under ETS, the sensitivity, specificity, PPV, NPV and accuracy was 64 %, 94 %, 88 %, 81 % and 83 %. Those under TSH suppression were 67 %, 92 %, 80 %, 85 % and 83 %. F-18 FDG PET/CT, although less sensitive, showed high specificity, PPV, NPV, and accuracy and therefore can be useful for the patients with negative diagnostic radioiodine scan and elevated serum Tg or positive TgAb. In addition, FDG PET/CT under ETS does not seem to have an additive role in detecting recurrence in these patients.

  12. Initial results and clinical application of non dedicated 18-FDG/PET in head and neck oncology

    Energy Technology Data Exchange (ETDEWEB)

    Correia, Luiz Mauricio; Priante, Antonio Vitor; Carvalho, Andre Lopes; Kowalski, Luiz Paulo [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil). Dept. de Cirurgia do Pescoco e da Cabeca]. E-mail: lp_kowalski@uol.com.br; Torres, Ivone Goncalves; Lima, Eduardo Nobrega Pereira [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil). Dept. de Radiologia

    2005-07-01

    Imaging procedures are important methods for proper stage and treatment planning. Especially in previously treated patients, although not perfectly accurate. PET scan is a functional and imaging technique that has been used to diagnose and stage recurrent cancer from different sites. The combination of computed tomography coupled with FDG-PET (18-FDG-PET/CT) reaches high quality anatomical and functional images. Objective: to describe the initial results of FDG-PET/CT performed at a single institution. Material and methods: this technique was used in 63 patients with head and neck tumors. The purposes of the exam were to rule out recurrent disease - 55 patients; to search for hidden primary tumor - 2 patients; and postoperative follow-up of residual disease - 6 patients. Computed tomography (CT) was performed in 56 cases (88.9%). Pathological confirmation was obtained in 24 cases (38.1%), all the remaining cases were considered negative based on clinical follow-up information with no evidence of recurrent disease 12 months after the PET/CT exam. Results: overall results for the accuracy of FDG-PET were: 93.9% of sensitivity, 64.2% of specificity, 75.6% of positive predictive value and 90.0% of negative predictive value. FDG-PET was able to find 1 out of 2 undetected primary tumors (base of the tongue). The best results were obtained regarding the detection of local and distant recurrences of larynx, thyroid and oral cavity cancers. Conclusion: the FDG-PET/CT fusion image makes anatomical localization easier and the accuracy for detection of recurrent disease was found to be higher than CT alone. (author)

  13. The role of 18FDG, 18FDOPA PET/CT and 99mTc bone scintigraphy imaging in Erdheim–Chester disease

    Energy Technology Data Exchange (ETDEWEB)

    García-Gómez, F.J., E-mail: javier191185@gmail.com [Department of Nuclear Medicine, Virgen del Rocío Universitary Hospital, Seville (Spain); Acevedo-Báñez, I.; Martínez-Castillo, R.; Tirado-Hospital, J.L.; Cuenca-Cuenca, J.I.; Pachón-Garrudo, V.M.; Álvarez-Pérez, R.M.; García-Jiménez, R. [Department of Nuclear Medicine, Virgen del Rocío Universitary Hospital, Seville (Spain); Rivas-Infante, E. [Department of Pathology, Virgen del Rocío Universitary Hospital, Seville (Spain); García-Morillo, J.S. [Department of Internal Medicine, Virgen del Rocío Universitary Hospital, Seville (Spain); Borrego-Dorado, I. [Department of Nuclear Medicine, Virgen del Rocío Universitary Hospital, Seville (Spain)

    2015-08-15

    Highlights: • Erdheim–Chester disease (ECD) is a rare non-Langerhans cell histiocitosis, characterized by multisystemic xanthogranulomatous infiltration by foamy histiocytes. Etiology and pathogenesis are still unknown and only about 500 cases are related in the literature. • Multifocal nature of involvement in ECD can produce a wide variety of clinical signs. In our experience, neurological involvement is associated with mortality in all cases. Characteristic long bone osteosclerosis was a quasi-pathognomonic finding in bone scintigraphy. • To the best of our knowledge, the 18FDOPA-PET/CT not seem useful in the initial staging of ECD based on a single case report. • Bone scintigraphy and the 18FDG-PET/CT that were particularly useful in despite systemic involvement, locate the optimum site for biopsy and treatment response evaluation. In this context, a baseline 18FDG-PET/CT with an optional bone scintigraphy may help in monitoring the disease and could be considered when patients were incidentally diagnosed and periodically follow-up 18FDG-PET/CT must be performed in the follow up to evaluate the treatment response. - Abstract: Erdheim–Chester disease (ECD) is a rare non-Langerhans cell histiocitosis, characterized by multisystemic xanthogranulomatous infiltration by foamy histiocytes that stain positively for CD68 marker but not express CD1a and S100 proteins. Etiology and pathogenesis are still unknown and only about 500 cases are related in the literature. Multisystemic involvement leads to a wide variety of clinical manifestations that results in a poor prognosis although recent advances in treatment. We present the clinical, nuclear medicine findings and therapeutic aspects of a serie of 6 patients with histopathological diagnosis of ECD, who have undergone both bone scintigraphy (BS) and 18F-fluorodeoxyglucose (18FDG)-PET/CT scans in our institution. A complementary 18F-fluorodopa (18FDOPA)-PET/CT was performed in one case. Three different

  14. SUV of 18FDG PET- CT for differential diagnosis of pancreatic neoplasms%18FDG PET - CT中SUV值对胰腺肿瘤鉴别诊断的作用

    Institute of Scientific and Technical Information of China (English)

    张雯杰; 吴宁; 郑容; 刘瑛; 梁颖; 李小萌; 姚雪松; 赵平

    2011-01-01

    目的 回顾性分析胰腺良恶性病变在PET -CT双时相显像中摄取18FDG的变化,寻找PET显像中最大SUV的诊断界值,以探讨其对胰腺良恶性病变诊断与鉴别诊断的临床应用价值.方法 2006年9至2010年9月118例胰腺良恶性病变患者.①胰腺癌患者65例,24例有病理或细胞学诊断,41例仅有影像学和临床诊断,并经临床和影像学随诊至少6个月所证实.其中56例患者同时行延迟PET -CT显像.②21例(23个病灶)胰腺转移瘤或胰腺实质受侵患者,均经临床和影像学随诊至少6个月所证实.其中13例患者(15个病灶)同时行延迟PET - CT显像.③32例患者计36个胰腺良性病灶或胰腺炎病灶,均经临床和影像学随诊至少6个月所证实.其中25例患者同时行延迟PET -CT显像.应用ROC曲线及配对t检验进行统计学分析.结果 88个胰腺癌或胰腺转移瘤/淋巴瘤受侵病灶的SUVmax为1.2~14.3,中位值为4.4;其中71个恶性病灶延迟显像后SUVmax为1.4~12.8,中位值为4.6.36个胰腺良性病变的SUVmax为0.8 ~5.7,中位值为1.8;其中25个胰腺良性病灶延迟显像后SUVmax为0.7~6.7,中位值为2.5.胰腺的良恶性病灶间SUVmax有统计学意义(P=0).SUVmax的ROC曲线下面积为0.8785,SUVmax为2.4时约登指数最大(0.63).当SUVmax≥2.4时,其诊断恶性病变的敏感性、特异性和准确性分别为93%、69%和86%.胰腺恶性病灶延迟显像前后SUV max差异有统计学意义(P =0.038),而胰腺良性病灶延迟显像前后SUVmax差异无统计学意义(P=0.720).结论 PET - CT诊断胰腺良恶性病变的SUVmax界值为2.4;胰腺恶性病灶延迟显像后升高,通过延迟显像可以提高胰腺癌诊断的准确性.%Objective To optimize the diagnostic cutoff value of SUVmax for differentiating malignant from benign lesions in the pancreas by retrospectively analyzing FDG PET - CT imaging, and to evaluate the diagnostic value of SUVmax for pancreas. Methods 18FDG PET - CT

  15. Utility of baseline 18FDG-PET/CT functional parameters in defining prognosis of primary mediastinal (thymic) large B-cell lymphoma.

    Science.gov (United States)

    Ceriani, Luca; Martelli, Maurizio; Zinzani, Pier Luigi; Ferreri, Andrés J M; Botto, Barbara; Stelitano, Caterina; Gotti, Manuel; Cabras, Maria Giuseppina; Rigacci, Luigi; Gargantini, Livio; Merli, Francesco; Pinotti, Graziella; Mannina, Donato; Luminari, Stefano; Stathis, Anastasios; Russo, Eleonora; Cavalli, Franco; Giovanella, Luca; Johnson, Peter W M; Zucca, Emanuele

    2015-08-20

    The International Extranodal Lymphoma Study Group (IELSG) 26 study was designed to evaluate the role of (18)F-fluorodeoxyglucose (18FDG) positron emission tomography/computed tomography (PET/CT) in the management of primary mediastinal (thymic) large B-cell lymphoma (PMBCL). We examined the prognostic impact of functional PET parameters at diagnosis. Metabolic activity defined by the maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) was measured on baseline 18FDG PET/CT following a standard protocol in a prospectively enrolled cohort of 103 PMBCL patients. All received combination chemoimmunotherapy with doxorubicin- and rituximab-based regimens; 93 had consolidation radiotherapy. Cutoff values were determined using the receiver-operating characteristic curve. At a median follow-up of 36 months, progression-free survival (PFS) and overall survival (OS) were 87% and 94%, respectively. In univariate analysis, elevated MTV and TLG were significantly associated with worse PFS and OS. Only TLG retained statistical significance for both OS (P = .001) and PFS (P < .001) in multivariate analysis. At 5 years, OS was 100% for patients with low TLG vs 80% for those with high TLG (P = .0001), whereas PFS was 99% vs 64%, respectively (P < .0001). TLG on baseline PET appeared to be a powerful predictor of PMBCL outcomes and warrants further validation as a biomarker. The IELSG 26 study was registered at www.clinicaltrials.gov as #NCT00944567.

  16. 18FDG-PET at 1-Month Intervals Is a Better Predictive Marker for GISTs That Are Difficult to Be Diagnosed Histopathologically: A Case Report

    Directory of Open Access Journals (Sweden)

    Kazunori Otsuka

    2011-01-01

    Full Text Available Imatinib mesylate is a tyrosine kinase inhibitor of c-KIT and PDGFRA. Imatinib mesylate is an effective drug that can be used as a first-choice agent for treatment of GISTs. Prior to treatment, molecular diagnosis of c-KIT or PDGFRA is necessary; however, in some types of GISTs, it is impossible to obtain a sufficient amount of specimen for diagnosis. An inoperable or marginally resectable GIST in a 79-year-old female was difficult to be diagnosed at a molecular pathological level, and hence, exploratory treatment was initiated using imatinib combined with 18FDG-PET evaluation at 1-month intervals. PET imaging indicated a positive response, and so we continued imatinib treatment in an NAC setting for 4 months. As a result, curative resection of the entire tumor was successfully performed with organ preservation and minimally invasive surgery. 18FDG-PET evaluation at 1-month intervals is beneficial for GISTs that are difficult to be diagnosed histopathologically.

  17. Volume-Based F-18 FDG PET/CT Imaging Markers Provide Supplemental Prognostic Information to Histologic Grading in Patients With High-Grade Bone or Soft Tissue Sarcoma

    DEFF Research Database (Denmark)

    Andersen, Kim Francis; Fuglo, Hanna Maria; Rasmussen, Sine Hvid;

    2015-01-01

    The aim of the study is to assess the prognostic value of different volume-based calculations of tumor metabolic activity in the initial assessment of patients with high-grade bone sarcomas (BS) and soft tissue sarcomas (STS) using F-18 FDG PET/CT.A single-site, retrospective study from 2002...... to 2012 including 92 patients with histologically verified high-grade BS (N = 37) or STS (N = 55). All patients underwent a pretreatment F-18 FDG PET/CT scan. Clinical data were registered. Measurements of the accuracy of metabolic tumor volume with a preset threshold of 40% of the maximum standardized.......05, HR 3.37 [95% CI 1.02-11.11]). No significant results were demonstrated for MTV40%.Volume-based F-18 FDG PET/CT imaging markers in terms of pretreatment estimation of TLG provide supplemental prognostic information to histologic grading, with significant independent properties for prediction...

  18. Monitoring of the Formation and Development Process for Infection and Inflammation Using F-18 FDG, PET/CT

    Directory of Open Access Journals (Sweden)

    Türkan Ertay

    2015-02-01

    Full Text Available Objective: Many radiopharmaceuticals have been evaluated extensively in both preclinical and clinical studies as potential diagnostic agents to identify the sites of infection. There is a definite role of FDG-PET in diagnosis, extent of assessing the disease, evaluation of treatment response and disease activity in patients with infections and inflammation. The aim of the study, the process of formation and development of infection and inflammation is monitored using (18 F 2’-deoxy-2-fluoroD-glucose (F-18 FDG by Positron Emission Computed Tomography (PET-CT. Methods: In this study, sterile abscess was induced by using turpentine and infected abscess was induced by using Staphylococcus aureus atcc 25923 strain on rats. In the abscess formation on rats, three grups rats were used as sterile, infected and control grups. There were examined male White Wistar Rats, the clinical healthy animals were 150-220 gr body weight. Bacterial strain and rat model for abscess formation for infected abscess formation on rats (n=7, S. aureus 0.5 ml 107 CFU/ml was inoculated in the right arm of the rats as subcutaneous. For sterile abscess formation on rats (n=7 0.2-0.4 ml turpentine (sigma-aldrich was injected into the right arm of the rats as subcutaneous. In control group (n=6, 0.5 ml 0.9% NaCl was injected into the right arm of the rats as subcutaneous. First day imsaging was acquired 24 hours after inoculation of S.aureus and turpentine. 1 mCi 18F-FDG was injected intravenously via the tail vein. Prior to 18F-FDG injection, rats fasted at least 4 hours and well hydrated. Imaging was done using PET-CT (PHILIPS Gemini TF, beginning 1 hour following injection of 18F-FDG IV in the first day and at intervals of 24 hours for five days. First day imaging was performed 1. hour after IV injection of 18F-FDG to obtain optimum imaging time. PET/CT images were visually and semiquantitatively assessed. For semiquantitative analysis of the PET images, a region of interest

  19. Diagnostic value of 18 FDG-PET/CT for poorly differentiated gastric adenocarcinoma%18 F-脱氧葡萄糖 PET/CT 对低分化胃腺癌的诊断价值

    Institute of Scientific and Technical Information of China (English)

    刘凯; 邹丹丹; 李琼; 贺琦; 刘士远

    2015-01-01

    Objective The sensitivity and specificity of 18 FDG PET/CT are poor in the diagnosis of gastric cancer .Gastric signet ring cell carcinoma and Mucinous gastric carcinoma is known to have low fluorodeoxyglucose (18FDG) uptake,but not known for poorly differentiated gastric adenocarcinoma .This study was to investigate the value of 18 FDG PET/CT in the diagnosis of poorly differ-entiated gastric adenocarcinoma . Methods We retrospectively analyzed the results of 18 FDG PET/CT of 34 cases of histologically confirmed poorly differentiated gastric adenocarcinoma .We recorded the volume , location , and gastric wall invasion depth , and maxi-mum standardized uptake value ( SUVmax) of the tumors and analyzed the relationship of 18 FDG uptake with the clinicopathologic pa-rameters. Results By 18 FDG-PET/CT, poorly differentiated gastric adenocarcinoma was diagnosed in only 67.6% of the patients (23/34).SUVmax was found to be significantly correlated with age , gastric wall invasion, and tumor size (P0 .05 ) .Logistic regression a-nalysis showed the tumor size to be the sole factor influencing the 18 FDG uptake of poorly differentiated gastric adenocarcinoma ( OR=0.37, 95%CI 0.154-0.920, P=0.03). Conclusion The di-agnostic value of 18 FDG-PET/CT is but limited for poorly differentia-ted gastric adenocarcinoma , and attention should be paid to its false-negative results .%目的:18 F-脱氧葡萄糖(18 F fluorodeoxyglucose ,18 FDG) PET/CT对胃癌的诊断敏感性及特异性不佳。文中旨在探讨18 F PET/CT对低分化胃腺癌的诊断价值。方法回顾性分析第二军医大学附属长征医院2012年4月至2014年7月经手术或胃镜病理证实为低分化胃腺癌的34例患者18 FDG PET/CT征象,记录肿瘤大小、位置、胃壁浸润深度及最大标准摄取值( maximum standardized uptake values , SUVmax)。分析18 FDG摄取阳性与各个临床病理参数关系。结果34例患者低分化胃腺癌诊断阳性率仅为67

  20. A meta-analysis of {sup 18}FDG-PET, MRI and bone scintigraphy for diagnosis of bone metastases in patients with breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Tao; Yang, Hui-Lin [The First Affiliated Hospital of Soochow University, Department of Orthopaedic Surgery, Suzhou (China); Cheng, Tao [Shanghai Jiaotong University School of Medicine, Department of Orthopaedic Surgery, Shanghai Sixth People' s Hospital, Shanghai (China); Xu, Wen [Public Health School of Soochow University, Department of Epidemiology and Biostatistics, Suzhou (China); Yan, Wei-Li [Shanghai Jiaotong University School of Medicine, Departments of Nuclear Medicine, Shanghai Renji Hospital, Shanghai (China); Liu, Jia [Shanghai Jiaotong University School of Medicine, Departments of Radiology, Shanghai Renji Hospital, Shanghai (China)

    2011-05-15

    To perform a meta-analysis comparing the diagnostic value of {sup 18}FDG-PET, MRI, and bone scintigraphy (BS) in detecting bone metastases in patients with breast cancer. MEDLINE, EMBASE, Scopus, ScienceDirect, SpringerLink, Web of Knowledge, EBSCO, and the Cochrane Database of Systematic Review databases were searched for relevant original articles published from January 1995 to January 2010. Inclusion criteria was as follows: {sup 18}FDG-PET, MRI or {sup 99m}Tc-MDP BS was performed to detect bone metastases (the number of published CT studies was inadequate for meta-analysis and therefore could not be included in this study); sufficient data were presented to construct a 2 x 2 contingency table; histopathological analysis and/or close clinical and imaging follow-up for at least 6 months were used as the reference standard. Two reviewers independently assessed potentially eligible studies and extracted relevant data. A software program called ''META-DiSc'' was used to obtain the pooled estimates for sensitivity, specificity, diagnostic odds ratio (DOR), summary receiver operating characteristic (SROC) curves, and the *Q index for each modality. Thirteen articles consisting of 23 studies fulfilled all inclusion criteria. On a per-patient basis, the pooled sensitivity estimates for MRI (97.1%) were significantly higher than those for PET (83.3%) and BS (87.0%; P <0.05). There was no significant difference between PET and BS (P <0.05). The pooled specificity estimates for PET (94.5%) and MRI (97.0%) were both significantly higher than those for BS (88.1%; P <0.05). There was no significant difference between PET and MRI (P >0.05). The pooled DOR estimates for MRI (298.5) were significantly higher than those for PET (82.1%) and BS (49.3%; P <0.05). There was no significant difference between PET and BS (P >0.05). The SROC curve for MRI showed better diagnostic accuracy than those for PET and BS. The SROC curve for PET was better than that for BS

  1. Pattern of cerebral glucose metabolism on F-18 FDG brain PET during vomiting and symptom free periods in cyclic vomiting syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yu Kyeong; Lee, Dong Soo; Kang, Eun Joo; Seo, Jeong Kee; Yeo, Jeong Seok; Chung, June Key; Lee, Myung Chul [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of)

    2001-06-01

    Cyclic Vomiting Syndrome (CVS) is characterized by recurrent, periodic, self-limiting vomiting. However, its pathogenesis is not yet established. We investigated the changes of the cerebral glucose metabolism using F-18 FDG during the vomiting attack and symptom free period in two children with CVS. FDG PET study showed the markedly increased metabolism in both temporal lobes and also in the medulla and cerebellum during the vomiting period. Also, FDG PET showed the decreased metabolism in the parieto-occipital and occipital areas during the in vomiting period. The area with decreased metabolism seemed to be related with the region showing abnormalities in EEG and perfusion SPECT studies. We expect that what we observed would be a helpful finding in clarifying the pathogenesis of the CVS.

  2. The differentiation of malignant and benign musculoskeletal tumors by F-18 FDG PET/CT studies-determination of maxSUV by analysis of ROC curve

    Energy Technology Data Exchange (ETDEWEB)

    Kong, Eun Jung; Cho, Ihn Ho; Chun, Kyung Ah; Won, Kyu Chang; Lee, Hyung Woo; Choi, Jun Heok; Shin, Duk Seop [Yeungnam University College of Medicine, Daegu (Korea, Republic of)

    2007-12-15

    We evaluated the standard uptake value (SUV) of F-18 FDG at PET/CT for differentiation of benign from malignant tumor in primary musculoskeletal tumors. Forty-six tumors (11 benign and 12 malignant soft tissue tumors, 9 benign and 14 malignant bone tumors) were examined with F-18 FDG PET/CT (Discovery ST, GE) prior to tissue diagnosis. The maxSUV(maximum value of SUV) were calculated and compared between benign and malignant lesions. The lesion analysis was based on the transverse whole body image. The maxSUV with cutoff of 4.1 was used in distinguishing benign from malignant soft tissue tumor and 3.05 was used in bone tumor by ROC curve. There was a statistically significant difference in maxSUV between benign (n = 11; maxSUV 3.4 {+-} 3.2) and malignant (n = 12; maxSUV 14.8 {+-} 12.2) lesion in soft tissue tumor ({rho} = 0.001). Between benign bone tumor (n = 9; maxSUV 5.4 {+-} 4.0) and malignant bone tumor (n = 14; maxSUV 7.3 {+-} 3.2), there was not a significant difference in maxSUV. The sensitivity and specificity for differentiating malignant from benign soft tissue tumor was 83% and 91%, respectively. There were four false positive malignant bone tumor cases to include fibrous dysplasia, Langerhans-cell histiocytosis (n = 2) and osteoid osteoma. Also, one false positive case of malignant soft tissue tumor was nodular fasciitis. The maxSUV was useful for differentiation of benign from malignant lesion in primary soft tissue tumors. In bone tumor, the low maxSUV correlated well with benign lesions but high maxSUV did not always mean malignancy.

  3. Nerve Sheath Tumors in Neurofibromatosis Type 1: Assessment of Whole-Body Metabolic Tumor Burden Using F-18-FDG PET/CT.

    Directory of Open Access Journals (Sweden)

    Johannes Salamon

    Full Text Available To determine the metabolically active whole-body tumor volume (WB-MTV on F-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT in individuals with neurofibromatosis type 1 (NF1 using a three-dimensional (3D segmentation and computerized volumetry technique, and to compare PET WB-MTV between patients with benign and malignant peripheral nerve sheath tumors (PNSTs.Thirty-six NF1 patients (18 patients with malignant PNSTs and 18 age- and sex-matched controls with benign PNSTs were examined by F-18-FDG PET/CT. WB-MTV, whole-body total lesion glycolysis (WB-TLG and a set of semi-quantitative imaging-based parameters were analyzed both on a per-patient and a per-lesion basis.On a per-lesion basis, malignant PNSTs demonstrated both a significantly higher MTV and TLG than benign PNSTs (p < 0.0001. On a per-patient basis, WB-MTV and WB-TLG were significantly higher in patients with malignant PNSTs compared to patients with benign PNSTs (p < 0.001. ROC analysis showed that MTV and TLG could be used to differentiate between benign and malignant tumors.WB-MTV and WB-TLG may identify malignant change and may have the potential to provide a basis for investigating molecular biomarkers that correlate with metabolically active disease manifestations. Further evaluation will determine the potential clinical impact of these PET-based parameters in NF1.

  4. Characteristics of Metastatic Mediastinal Lymph Nodes of Non-Small Cell Lung Cancer on Preoperative F-18 FDG PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ah Young; Choi, Su Jung; Jung, Kyung Pyo; Park, Ji Sun; Lee, Seok Mo; Bae, Sang Kyun [Inje Univ. College of Medicine, Gimhae (Korea, Republic of)

    2014-03-15

    The aim of this study was to evaluate the characteristics of PET and CT features of mediastinal metastatic lymph nodes on F-18 FDG PET/CT and to determine the diagnostic criteria in nodal staging of non-small cell lung cancer. One hundred four non-small cell lung cancer patients who had preoperative F-18 FDG PET/CT were included. For quantitative analysis, the maximum SUV of the primary tumor, maximum SUV of the lymph nodes (SUVmax), size of the lymph nodes, and average Hounsfield units (aHUs) and maximum Hounsfield units (mHUs) of the lymph nodes were measured. The SUVmax, SUV ratio of the lymph node to blood pool (LN SUV/blood pool SUV), SUV ratio of the lymph node to primary tumor (LN SUV/primary tumor SUV), size, aHU, and mHU were compared between the benign and malignant lymph nodes. Among 372 dissected lymph node stations that were pathologically diagnosed after surgery, 49 node stations were malignant and 323 node stations benign. SUVmax, LN SUV/blood pool SUV, and size were significantly different between the malignant and benign lymph node stations (P <0.0001). However, there was no significant difference in LN SUV/primary tumor SUV (P =0.18), mHU (P =0.42), and aHU (P =0.98). Using receiver-operating characteristic curve analyses, there was no significant difference among these three variables (SUVmax, LN SUV/blood pool SUV, and size). The optimal cutoff values were 2.9 for SUVmax, 1.4 for LN SUV/blood pool SUV, and 5 mm for size. When the cutoff value of SUVmax≥2.9 and size≥5 mm were used in combination, the positive predictive value was 44.2%, and the negative predictive value was 90.9 %. When we evaluated the results based on the histology of the primary tumor, the negative predictive value was 92.3 % in adenocarcinoma (cutoff values of SUVmax≥2.3 and size≥5 mm) and 97.2 % in squamous cell carcinoma (cutoff values of SUVmax≥3.6 and size≥8 mm), separately. In the lymph node staging of non-small cell lung cancer, SUVmax, LN SUV/blood pool SUV

  5. Diffuse Hypermetabolism at Bone Marrow in F-18 FDG PET/CT: Correlation with Bone Marrow Biopsy and Complete Blood Cell Counts

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Yun Hee; Lim, Seok Tae; Jeong, Young Jin; Kim, Dong Wook; Jeong, Hwan Jeong; Sohn, Myung Hee [Chonbuk National University Medical School, Jeonju (Korea, Republic of)

    2009-02-15

    Increased FDG uptake in the bone marrow has been reported in patients taking erythropoietin or granulocyte-colony stimulating factor (G-CSF). The aim of this study is to investigate the correlation between F-18 FDG uptake in the bone marrow and bone marrow finding, hematological parameters. Twenty patients who had diffuse FDG uptake at the bone marrow and received hematological examinations, bone marrow biopsy within 10 days before or after PET/CT were enrolled in this study. Among them, 11 patients were excluded; 4 patients received G-CSF or erythropoietin before PET/CT. Seven patients showed definite pathology in a bone marrow biopsy. The parameters included the measurement of WBC, hemoglobin, platelet and cellularity of the bone marrow. Bone marrow FDG uptake was correlated with a low hemoglobin but not WBC, platelet. Histopathologic findings in marrow biopsies were various: normal finding (n=3), hyperplasia of granulocytic cells (n=2), eosinophilic hyperplasia (n=1), reactive lymphoid nodules (n=1), hypercelluar marrow (n=1), hypocelluar marrow (n=1). All patients except two, showed normal marrow celluarity. FDG uptake by bone marrow correlated with anemia but not WBC, platelet, bone marrow cellularity.

  6. Isolated Granulocytic Sarcoma of the Breast after Allogeneic Stem Cell Transplantation: A Rare Involvement Also Detected by 18FDG-PET/CT

    Directory of Open Access Journals (Sweden)

    Eren Gündüz

    2014-03-01

    Full Text Available Granulocytic sarcoma is a tumor consisting of myeloid blasts with or without maturation that occurs at an anatomical site other than bone marrow. Most frequently affected sites are skin, lymph nodes, gastrointestinal tract, bone, soft tissue and testes. AML may manifest as granulocytic sarcoma at diagnosis or relapse. Although it has been considered to be rare relapse as granulocytic sarcoma after stem cell transplantation is being increasingly reported. However it is rare without bone marrow involvement and in AML M6 subtype. Breast is also a rare involvement. We report a 30-year-old woman with AML M6 relapsed 16 months after allogeneic stem cell transplantation as a granulocytic sarcoma in right breast without bone marrow involvement. She was treated with systemic chemotherapy but died of sepsis. 18FDG-PET/CT images were also obtained and detected lesions other than detected by breast ultrasound. The incidence of granulocytic sarcoma may increase if suspected or new diagnostic modalities are performed.

  7. P11: 18FDG-PET/CT for early prediction of response to first line platinum chemotherapy in advanced thymic epithelial tumors

    Science.gov (United States)

    Palmieri, Giovannella; Ottaviano, Margaret; Del Vecchio, Silvana; Segreto, Sabrina; Tucci, Irene; Damiano, Vincenzo

    2015-01-01

    Background To investigate the value of the metabolic tumor response assessed with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), compared with clinicobiological markers, to predict the response disease to first line platinum based chemotherapy in advanced thymic epithelial tumors (TETs). Methods Twenty patients with diagnosis of TET and stage of disease III and IV sec, Masaoka-Koga, were retrospectively included in this monocentric study. Different pre-treatment clinical, biological and pathological parameters, including histotype sec, WHO 2004 and stage of disease sec, Masaoka-Koga were assessed. Tumor glucose metabolism at baseline and its change after the first line platinum based chemotherapy (from 4 to 6 cycles) were assessed using FDG-PET, moreover the response disease was assessed using total body CT scan for the evaluation of RECIST criteria 1.1. Results Twelve patients had an objective response to the first line platinum based chemotherapy according RECIST criteria 1.1 and all of them started with a SUVmax at baseline major than 5, indeed the other eight patients, non-responders to chemotherapy, had a SUVmax at baseline minor than 5. Conclusions It is important to define the chemosensitivity of advanced TETs early. Combining bio-pathological parameters with the metabolism at baseline assessed with FDG-PET can help the physician to early predict the probability of obtaining a disease response to first line platinum based chemotherapy. The SUVmax cut off of 5 at 18FDG-PET/CT performed at baseline treatment might be a new parameter for choosing the most powerful first line of chemotherapy. Given these results, further prospective studies are needed to establish a new first line therapy in advanced TETs with a low SUVmax at baseline, non-responders to conventional chemotherapy.

  8. Optimizing the interval between G-CSF therapy and F-18 FDG PET imaging in children and young adults receiving chemotherapy for sarcoma

    Energy Technology Data Exchange (ETDEWEB)

    Trout, Andrew T.; Sharp, Susan E.; Gelfand, Michael J. [Cincinnati Children' s Hospital Medical Center, Department of Radiology, Cincinnati, OH (United States); Turpin, Brian K. [Cincinnati Children' s Hospital Medical Center, Cancer and Blood Diseases Institute, Division of Oncology, Cincinnati, OH (United States); Zhang, Bin [Cincinnati Children' s Hospital Medical Center, Division of Biostatistics and Epidemiology, Cincinnati, OH (United States)

    2015-07-15

    Granulocyte colony-stimulating factors (G-CSF) speed recovery from chemotherapy-induced myelosuppression but the marrow stimulation they cause can interfere with interpretation of F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) exams. To assess the frequency of interfering G-CSF-induced bone marrow activity on FDG PET imaging in children and young adults with Ewing sarcoma and rhabdomyosarcoma and to define an interval between G-CSF administration and FDG PET imaging that limits marrow interference. Blinded, retrospective review of FDG PET exams performed in patients treated with long-acting G-CSF as part of their chemotherapeutic regimen. Exams were subjectively scored by two reviewers (R1 and R2) who assessed the level of marrow uptake of FDG and measured standardized uptake values in the marrow, liver, spleen and blood pool. FDG PET findings were correlated with time since G-CSF administration and with blood cell counts. Thirty-eight FDG PET exams performed in 17 patients were reviewed with 47.4% (18/38) of exams having marrow uptake of FDG sufficient to interfere with image interpretation. Primary predictors of marrow uptake of FDG were patient age (P = 0.0037) and time since G-CSF exposure (P = 0.0028 for subjective marrow uptake of FDG, P = 0.008 [R1] and P = 0.004 [R2] for measured maximum standardized uptake value (SUVmax)). The median interval between G-CSF administration and PET imaging in cases with marrow activity considered normal or not likely to interfere was 19.5 days (range: 7-55 days). In pediatric and young adult patients with Ewing sarcoma and rhabdomyosarcoma, an interval of 20 days between administration of the long-acting form of G-CSF and FDG PET imaging should limit interference by stimulated marrow. (orig.)

  9. ''Ecstasy''-induced changes of cerebral glucose metabolism and their correlation to acute psychopathology. A 18-FDG PET study

    Energy Technology Data Exchange (ETDEWEB)

    Schreckenberger, M.; Sabri, O.; Arning, C.; Zimny, M.; Zeggel, T.; Wagenknecht, G.; Kaiser, H.J.; Buell, U. [Technische Hochschule Aachen (Germany). Klinik fuer Nuklearmedizin; Gouzoulis-Mayfrank, E.; Sass, H. [Technische Hochschule Aachen (Germany). Dept. of Psychiatry

    1999-12-01

    The aim of this study was to determine the acute effects of the 'Ecstasy' analogue MDE (3,4-methylene dioxyethamphetamine) on cerebral glucose metabolism (rMRGlu) of healthy volunteers and to correlate neurometabolism with acute psychopathology. In a radomized double-blind trial, 15 healthy volunteers without a history of drug abuse were examined with fluorine-18-deoxyglucose ({sup 18}FDG) positron emission tomography (PET) 110-120 min after oral administration of 2 mg/kg MDE (n=7) or placebo (n=8). Two minutes prior to radiotracer injection, constant cognitive stimulation was started and maintained for 32 min using a word repetition paradigm to ensure constant and comparable mental conditions during cerebral glucose uptake. Individual brain anatomy was represented using T1-weighted 3D flash magnetic resonance imaging (MRI), followed by manual regionalization into 108 regions of interest and PET/MRI overlay. After absolute quantification of rMR-Glu and normalization to global metabolism, normalized rMRGlu under MDE was compared to placebo using the Mann-Whitney U-test. Acute psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS) and rMRGlu was correlated to PANSS scores according to Spearman. MDE subjects showed significantly decreased rMRGlu in the bilateral frontal cortex: left frontal posterior (-7.1%, P<0.05) and right prefrontal superior (-4.6%, P<0.05). On the other hand, rMR-Glu was significantly increased in the bilateral cerebellum (right: +10.1%, P<0.05; left: +7.6%, P<0.05) and in the right putamen (+6.2%, P<0.05). There were positive correlations between rMRGlu in the middle right cingulate and grandiosity (r=0.87; P<0.05), both the right amygadala (r=0.90, P<0.01) and the left posterior cingulate (r=0.90, P<0.01) to difficulties in abstract thinking, and the right frontal inferior (r=0.85, P<0.05), right anterior cingulate (r=0.93, P<0.01), and left anterior cingulate (r=0.85, P<0.05) to attentional deficits. A

  10. The Clinical Value of Dual Time Point F-18 FDG PET/CT Imaging for the Differentiation of Colonic Focal Uptake Lesions

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jin Suk; Lim, Seok Tae; Jeong, Young Jin; Kim, Dong Wook; Jeong, Hwan Jeong; Sohn, Myung Hee [Chonbuk National University Medical School and Hospital, Jeonju (Korea, Republic of)

    2009-08-15

    F-18 FDG can be accumulated in the liver, bowel, kidney, urinary tract, and muscles physiologically. The aim of this study was to evaluate the clinical value of dual time point 18F-FDG PET/CT imaging for the differentiation of the colonic focal uptake lesions. One hundred thirty two patients (M:F=77:55, Age 62.8{+-}11.6 years) underwent {sup 18}F-FDG PET/CT at two time points, prospectively: early image at 50-60 min and delayed image at 4-4.5 hours after the intravenous injection of {sup 18}F-FDG. Focally increased uptake lesions on early images but disappeared or shifted on delayed images defined a physiological uptake. For the differential evaluation of persistent focal uptake lesions on delayed images, colonoscopy and histopathologic examination were performed. SUVmax changes between early and delayed images were also compared. Among the 132 patients, 153 lesions of focal colonic uptake were detected on early images of {sup 18}F-FDG PET/CT. Of these, 72 (47.1%) lesions were able to judge with physiological uptake because the focal increased uptake disappeared from delayed image. Among 81 lesions which was showed persistent increased uptake in delayed image, 61 (75.3%) lesions were confirmed as the malignant tumor and 14 (17.3%) lesions were confirmed as the benign lesions including adenoma and inflammatory disease. Remaining 6 (7.4%) lesions were confirmed as the physiological uptake because there was no particular lesion in the colonoscopy. In the malignant lesions, the calculated dual time point change for SUVmax ({delta}%SUVmax) was 20.8%{+-}18.7%, indicating a significant increase in SUVmax between the two point (p<0.01). In contrast, the change in SUVmax for the non-malignant lesions including benign lesions and physiological uptake was -13.7%{+-}24.2%. For the differentiation of the malignant and non-malignant focal colonic uptake lesions, {delta}%SUVmax was the most effective parameter, and the cut-off value using -5% provided the best sensitivity

  11. [Role of 18FDG-PET/CT in the management and gross tumor volume definition for radiotherapy of head and neck cancer; single institution experiences based on long-term follow-up].

    Science.gov (United States)

    Hideghéty, Katalin; Cserháti, Adrienne; Besenyi, Zsuzsanna; Zag, Levente; Gaál, Szilvia; Együd, Zsófia; Mózes, Petra; Szántó, Erika; Csenki, Melinda; Rusz, Orsolya; Varga, Zoltán; Dobi, Ágnes; Maráz, Anikó; Pávics, László; Lengyel, Zsolt

    2015-06-01

    The purpose of our work is evaluation of the impact of 18FDG-PET/CT on the complex management of locoregionally advanced (T3-4N1-3) head and neck squamous cell cancer (LAHNSC), and on the target definition for 3D conformal (3DCRT) and intensity-modulated radiotherapy (IMRT). 18FDG-PET/CT were performed on 185 patients with LAHNSC prior to radiotherapy/chemoradiation in the treatment position between 2006 and 2011. Prior to it 91 patients received induction chemotherapy (in 20 cases of these, baseline PET/CT was also available). The independently delineated CT-based gross tumor volume (GTVct) and PET/CT based ones (GTVpet) were compared. Impact of PET/CT on the treatment strategy, on tumor response evaluation to ICT, on GTV definition furthermore on overall and disease-specific survival (OS, DSS) was analysed. PET/CT revealed 10 head and neck, 2 lung cancers for 15 patients with carcinoma of unknown primary (CUP) while 3 remained unknown. Second tumors were detected in 8 (4.4%), distant metastasis in 15 (8.2%) cases. The difference between GTVct and GTVpet was significant (p=0.001). In 16 patients (14%) the GTVpet were larger than GTVct due to multifocal manifestations in the laryngo-pharyngeal regions (4 cases) or lymph node metastases (12 cases). In the majority of the cases (82 pts, 72%) PET/CT-based conturing resulted in remarkable decrease in the volume (15-20%: 4 cases, 20-50%: 46 cases, >50%: 32 cases). On the basis of the initial and post-ICT PET/CT comparison in 15/20 patients more than 50% volume reduction and in 6/20 cases complete response were achieved. After an average of 6.4 years of follow-up the OS (median: 18.3±2.6 months) and DSS (median: 25.0±4.0 months) exhibited close correlation (p=0.0001) to the GTVpet. In cases with GTVpet 40 cm3 the median DSS was 8.4±0.96 months (HR= 11.48; 95% CI: 5.3-24.9). Our results suggest that 18FDG-PET/CT plays an important role for patient with LAHNSC, by modifying the treatment concept and improving the target

  12. Correlation between PET-CT 18FDG uptake in primary lesions and clinicopathological parameters in esophageal carcinoma patients%食管癌原发灶PET-CT氟代脱氧葡萄糖摄取及其与临床病理参数的相关性

    Institute of Scientific and Technical Information of China (English)

    冯瑞; 李明焕; 孔莉; 石芳; 杨国仁; 于金明

    2009-01-01

    目的 从分子影像学角度,探讨治疗前食管癌原发灶PET-CT氟代脱氧葡萄糖(FDG)摄取与病变长度、肿瘤浸润深度、组织分化程度以及淋巴结转移状况的关系.方法 68例食管鳞癌患者术前行FDG PET-CT检查,测定最大标准摄取值(SUVmax),根据术后病理确定其病变长度、浸润深度、分化程度以及淋巴结转移情况.结果 68例食管癌患者肿瘤原发灶的SUVmax为10.7±5.3.不同浸润深度、分化程度及淋巴结转移情况的食管癌SUVmax差异均有统计学意义(均P<0.05).原发灶SUVmax与病变长度、浸润深度、分化程度及淋巴结转移情况均呈正相关(r=0.512,P=0.01;r=0.860,P=0.000;r=0.781,P=0.000;r=0.852,P=0.000).结论 食管癌原发灶SUVmax与病变长度、浸润深度、分化程度均呈正相关,发生淋巴结转移者原发灶的SUVmax高于无淋巴结转移者.%Objective To investigate the correlation between 18F-fluorodeoxyglucose (18FDG) uptake of primary lesions during PET-CT (positron emission tomography and computed tomography) examination and clinicopathological parameters such as the tumor length, depth of invasion, differentiation of the primary lesions and lymph node metastasis status in the patients with esophageal carcinoma. Methods From June 2004 to November 2006, 68 operable esophageal carcinoma patients were enrolled into this study, and all had a whole body 18FDG PET-CT scan before operation. The maximum standardized uptake value (SUVmax) of the primary lesions was measured. The tumor length, depth of invasion, differentiation of the primary lesions and lymph node metastasis status were determined by postoperative pathological examination. The correlation between the standardized uptake value (SUV) of primary lesions and the above mentioned clinicopathological parameters was analyzed. Results The overall length of primary lesion was positively correlated with SUVmax (r = 0. 512, P = 0.01 ). Depth of invasion was also positively

  13. 18FDG, [18F]FLT, [18F]FAZA, and 11C-Methionine Are Suitable Tracers for the Diagnosis and In Vivo Follow-Up of the Efficacy of Chemotherapy by miniPET in Both Multidrug Resistant and Sensitive Human Gynecologic Tumor Xenografts

    Directory of Open Access Journals (Sweden)

    György Trencsényi

    2014-01-01

    Full Text Available Expression of multidrug pumps including P-glycoprotein (MDR1, ABCB1 in the plasma membrane of tumor cells often results in decreased intracellular accumulation of anticancer drugs causing serious impediment to successful chemotherapy. It has been shown earlier that combined treatment with UIC2 anti-Pgp monoclonal antibody (mAb and cyclosporine A (CSA is an effective way of blocking Pgp function. In the present work we investigated the suitability of four PET tumor diagnostic radiotracers including 2-[18F]fluoro-2-deoxy-D-glucose (18FDG, 11C-methionine, 3′-deoxy-3′-[18F]fluorothymidine (18F-FLT, and [18F]fluoroazomycin-arabinofuranoside (18FAZA for in vivo follow-up of the efficacy of chemotherapy in both Pgp positive (Pgp+ and negative (Pgp− human tumor xenograft pairs raised in CB-17 SCID mice. Pgp+ and Pgp− A2780AD/A2780 human ovarian carcinoma and KB-V1/KB-3-1 human epidermoid adenocarcinoma tumor xenografts were used to study the effect of the treatment with an anticancer drug doxorubicin combined with UIC2 and CSA. The combined treatment resulted in a significant decrease of both the tumor size and the accumulation of the tumor diagnostic tracers in the Pgp+ tumors. Our results demonstrate that 18FDG, 18F-FLT, 18FAZA, and 11C-methionine are suitable PET tracers for the diagnosis and in vivo follow-up of the efficacy of tumor chemotherapy in both Pgp+ and Pgp− human tumor xenografts by miniPET.

  14. TO STORES USERS

    CERN Multimedia

    SPL Division

    2001-01-01

    Stores users are informed that the Stores (Central, Emergency window, Raw materials, Chemical products and Prévessin Self service stores) will be closed on Friday, 7 December owing to migration of the Stores computers to Windows 2000. Thank you for your understanding.

  15. Information for Stores Users

    CERN Multimedia

    Logistics Group

    2004-01-01

    As the FARNELL Catalogue CAPACITORS, RESISTORS and POTENTIOMETERS have now been integrated into the CERN Stores Catalogue (SCEM Groups 10 and 11) they can now be obtained via an EDH 'Material Request' like any other Stores item. N.B. The Farnell 'Order code' is one of the key-words that make it easier to find items in the Stores Catalogue. Logistics Group FI Department

  16. Information for stores users

    CERN Multimedia

    2005-01-01

    The Farnell catalogue can now be accessed from the Material Request form on EDH in addition to the CERN Stores catalogue. Users can order Farnell equipment as well as standard Stores equipment at the same time using a single document, the EDH Materials Request form. The Materials Request form offers users items from both the internal 'Stores' catalogue and the external 'Farnell' catalogue, all of which may be ordered on the same form. The system automatically forwards orders for standard Stores equipment to the CERN Stores and those for Farnell equipment to Farnell. The delivery time is 48 hours in both cases. Requests for materials are routed for approval in accordance with the standard EDH routing procedures. Logistics Group FI Department

  17. Information for stores users

    CERN Multimedia

    2006-01-01

    The Radiospares Catalogue is now accessible from the Material Request page on EDH in the same way as the CERN Stores Catalogue. This means that users can order Radiospares equipment by completing an EDH Materials Request form. N.B.: The system will automatically forward orders for standard Stores equipment to the CERN Stores and those for Radiospares equipment to Radiospares. In both cases the delivery time will be a maximum of 48 hours. Requests for materials will be routed for approval in accordance with the standard EDH routing procedures. Logistics Group FI Department

  18. INFORMATION FOR STORES USERS

    CERN Multimedia

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    1999-01-01

    You can now make Material Request from CERN Stores over the WEB :CERN Home/Administrative Tools/EDH/Material Requestor https://edh.cern.ch/Document/MAGVia the Stores Catalogue : CERN Home/Administrative Tools/Stores Catalogueor http://edhcat.cern.ch/In both cases, you need to enter your EDH login and password.For more details, you can consult the Quick Reference Guide on :http://edh.cern.ch/doc/quickrefguides.htmlor obtain a printed version from AIS Support at tel: 79933or e-mail to: ais.support@cern.chSPL DivisionLogistics Group

  19. INFORMATION FOR STORES USERS

    CERN Multimedia

    2007-01-01

    From next week, the SFS UNIMARKET (tooling) catalogue will be accessible using the Material Request form on EDH in addition to the CERN Stores catalogue and those of existing suppliers. Users will now be able to place orders from the SFS catalogue using the Material Request form on EDH. Note: The system automatically forwards orders for standard Stores equipment and those for SFS equipment, placed using the same Material Request form, to the CERN Stores and SFS respectively. In both cases, the maximum delivery time will be 48 hours. Requests for equipment will be routed for approval in accordance with standard EDH routing procedures. Logistics Group FI Department

  20. Information for stores users

    CERN Multimedia

    2007-01-01

    From next week, the SFS UNIMARKET (tooling) catalogue will be accessible using the Material Request form on EDH in addition to the CERN Stores catalogue and those of existing suppliers. Users will now be able to place orders from the SFS catalogue using the Material Request form on EDH. Note: The system automatically forwards orders for standard Stores equipment and those for SFS equipment, placed using the same Material Request form, to the CERN Stores and SFS respectively. In both cases, the maximum delivery time will be 48 hours. Requests for equipment will be routed for approval in accordance with standard EDH routing procedures. Logistics Group FI Department

  1. Information for stores users

    CERN Multimedia

    2006-01-01

    The Bossard catalogue is now accessible alongside the CERN Stores catalogue from the Material Request form on EDH. Users will thus be able to order Bossard equipment using the EDH Materials Request form. As a reminder, the system automatically forwards orders for standard Stores equipment to the CERN Stores and those for Bossard equipment to Bossard. In both cases the delivery time will be a maximum of 48 hours. Requests for materials will be routed for approval in accordance with the standard EDH routing procedures. Some items will remain available from the emergency desk in the event of urgent requests. These items will be visible in the Stores catalogue even if they cannot be purchased via the EDH material request form. Logistics Group FI Department

  2. Provenance Store Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Paulson, Patrick R.; Gibson, Tara D.; Schuchardt, Karen L.; Stephan, Eric G.

    2008-03-01

    Requirements for the provenance store and access API are developed. Existing RDF stores and APIs are evaluated against the requirements and performance benchmarks. The team’s conclusion is to use MySQL as a database backend, with a possible move to Oracle in the near-term future. Both Jena and Sesame’s APIs will be supported, but new code will use the Jena API

  3. Den store skandinaviske redningsaktion

    DEFF Research Database (Denmark)

    Christensen, Claus Bundgård

    2015-01-01

    Historikeren Bo Lidegaard fortæller flot den store historie om den forbløffende og komplicerede skandinaviske redning af fanger fra Hitlers koncentrationslejre. En historie, der samtidig berører alvorlige moralske spørgsmål.......Historikeren Bo Lidegaard fortæller flot den store historie om den forbløffende og komplicerede skandinaviske redning af fanger fra Hitlers koncentrationslejre. En historie, der samtidig berører alvorlige moralske spørgsmål....

  4. Information for Stores users

    CERN Multimedia

    FI Department

    2008-01-01

    The DISTRELEC catalogue (IT) is now available in EDH in addition to the CERN Stores catalogue and the catalogues of existing suppliers. Using an EDH materials request form, users can now order DISTRELEC equipment from amongst the following product groups: peripherals, multimedia, PC components, data media, communication and data cables and adapters. Non-authorised materials will be clearly indicated. As a reminder, the system automatically manages the distribution of standard Stores equipment and punch out equipment ordered on the same request form. In both cases, delivery will take a maximum of 48 hours. The approval of the EDH document will follow the usual EDH routing procedures. Logistics Group FI Department

  5. Information for stores users

    CERN Multimedia

    FI Department

    2008-01-01

    From the beginning of March onwards, the LYRECO (stationery) catalogue will be accessible from the Material Request form on EDH in the same way as the CERN Stores catalogue and the existing individual supplier catalogues. Items will be delivered within a maximum of 48 hours. Logistics Group FI Department

  6. 18FDG PET and ultrasound echolucency in carotid artery plaques

    DEFF Research Database (Denmark)

    Graebe, Martin; Pedersen, Sune F; Højgaard, Liselotte;

    2010-01-01

    for ultrasound and PET imaging. Plaque standardized gray scale medians (GSM) were measured in longitudinal ultrasound images to quantitate echolucency, and GSM values were compared with FDG PET uptake quantified by maximum standardized uptake values (SUV). Symptomatic plaques were compared with contralateral...... carotid artery plaques considered asymptomatic, and in 17 symptomatic patients, endarterectomized plaque specimens were analyzed for CD68 expression. RESULTS: There was a negative correlation between GSM and FDG SUV (r = -0.56, p ... plaques ranged from high to low inflammatory activity, as depicted with PET. Quantitative FDG SUV differentiated asymptomatic from symptomatic plaques, whereas GSM values did not. There was a positive correlation between CD68 expression and FDG uptake (r = 0.50, p = 0.04). CONCLUSIONS: Our results...

  7. Study on optimized dispensing of F-18 FDG auto dispenser

    Energy Technology Data Exchange (ETDEWEB)

    Ji, Bong Geun; Lee, Sang Hun; Kim, Jong Eon; Kim, Won Tae; Kim, Tae Jeong [Dept. of Radiological Science, Kaya University, Kimhae (Korea, Republic of)

    2016-09-15

    This is a study on the optimized dispensing of the auto dispenser used for the purpose of reducing the exposure dose and accurate radiation dose of radioisotope with regard to the PET/CT practitioners. The research method was to find the optimized dispensing method through evaluating the results according to the syringe type, dispensing rate, and vial pressure and through the application of corrected values. As a result of this study, 9.38 mCi has been dispensed on average in the case of 5 ml syringe, and the reproducibility close to 10 mCi was shown at the dispense of 9.55 mCi in the case of 3 ml syringe. In the evaluation according to the dispensing rate, the quantity of radioisotope close to 10 mCi was dispensed at the rate of 5 mm/min when the measurement was carried out by increasing the rate by 5 mm/min units in the order of 5, 10, 15 and 20 mm/min . In the evaluation result according to the vial pressure before/after the use of Needle filter, it was measured to be 9.53 mCi before use and 9.84 mCi after use confirming that the dispensing after using Needle filter showed the optimal value. In addition, in the evaluation of radioactivity before/after the application of corrected values according to the increase in dispense frequency, it was measured 9.53 mCi before correction and 10.07 mCi after correction confirming that the value with correction applied was closer to the quantitative value. Thus, a good optimized method was confirmed to use a 3 ml syringe with dispensing rate of 5 mm/min, to use a Needle filter at dispensing, and to set the corrected value of [y = 0.097 × χ] according to the dispensing frequency of equipment.

  8. Gene expression and 18FDG uptake in atherosclerotic carotid plaques

    DEFF Research Database (Denmark)

    Pedersen, Sune Folke; Græbe, Martin; Hag, Anne Mette Fisker;

    2010-01-01

    ) and an additional ipsilateral internal carotid artery stenosis of greater than 60% were recruited. FDG uptake in the carotids was determined by PET/computed tomography and expressed as mean and maximal standardized uptake values (SUVmean and SUVmax). The atherosclerotic plaques were subsequently recovered...... as SUVmax (R=0.30, Puptake. We suggest that FDG uptake is a composite indicator of macrophage load, overall inflammatory activity and collagenolytic plaque...

  9. Storing Blood Cells

    Science.gov (United States)

    1976-01-01

    The National Cancer Institute worked with Goddard Space Flight Center to propose a solution to the blood-cell freezing problem. White blood cells and bone marrow are stored for future use by leukemia patients as a result of Goddard and Jet Propulsion Laboratory expertise in electronics and cryogenics. White blood cell and bone marrow bank established using freezing unit. Freezing unit monitors temperature of cells themselves. Thermocouple placed against polyethylene container relays temperature signals to an electronic system which controls small heaters located outside container. Heaters allow liquid nitrogen to circulate at constant temperature and maintain consistent freezing rate. Ability to freeze, store, and thaw white cells and bone marrow without damage is important in leukemia treatment.

  10. Store and forward teledermatology.

    Science.gov (United States)

    Kanthraj, Garehatty Rudrappa; Srinivas, Chakravarty Rangachari

    2007-01-01

    Store and forward and real time or videoconferences are the two types of teledermatology services practiced. Dermatology and radio-diagnosis are visual specialties suited for store-and-forward teledermatology (SAFT). Advances in information technology, electronic instruments and biotechnology have revolutionized and brought changes in SAFT. Cellular phone, digital camera, personal digital assistants, Wi-Fi, Wi-Max and computer- aided-design software are incorporated to deliver the quality health care to remote geographic regions. Complete SAFT care equivalent to face-to-face consultation (Gold standard) is essential. Health care providers in rural areas are the 'eyes' for the consultants. Consultants to guide them should have a rapid periodic audit of visual parameters and dimensions of lesions. Given this background, this article reviews advances in 1) capture, store and transfer of images. 2) Computer Aided measurements of generalized and localized lesions and 3) the integration model to meet all the above two requirements in a centralized location. This process enables diagnosis, management, periodic assessment and complete follow-up care to achieve patient and physician satisfaction. Preservation of privacy and confidentiality of digital images is important. Uniform rules and regulations are required. Indian space research organization (ISRO), Government of India has demonstrated telemedicine pilot projects utilizing the satellite communication and mobile telemedicine units to be useful in meeting the health care needs of remote and rural India. we have to join hands with them to meet dermatology problems in rural areas.

  11. Store and forward teledermatology

    Directory of Open Access Journals (Sweden)

    Kanthraj Garehatty

    2007-01-01

    Full Text Available Store and forward and real time or videoconferences are the two types of teledermatology services practiced. Dermatology and radio-diagnosis are visual specialties suited for store-and-forward teledermatology (SAFT. Advances in information technology, electronic instruments and biotechnology have revolutionized and brought changes in SAFT. Cellular phone, digital camera, personal digital assistants, Wi-Fi, Wi-Max and computer- aided-design software are incorporated to deliver the quality health care to remote geographic regions. Complete SAFT care equivalent to face-to-face consultation (Gold standard is essential. Health care providers in rural areas are the ′eyes′ for the consultants. Consultants to guide them should have a rapid periodic audit of visual parameters and dimensions of lesions. Given this background, this article reviews advances in 1 capture, store and transfer of images. 2 Computer Aided measurements of generalized and localized lesions and 3 the integration model to meet all the above two requirements in a centralized location. This process enables diagnosis, management, periodic assessment and complete follow-up care to achieve patient and physician satisfaction. Preservation of privacy and confidentiality of digital images is important. Uniform rules and regulations are required. Indian space research organization (ISRO, Government of India has demonstrated telemedicine pilot projects utilizing the satellite communication and mobile telemedicine units to be useful in meeting the health care needs of remote and rural India. we have to join hands with them to meet dermatology problems in rural areas.

  12. Stored Luminescence Computed Tomography

    CERN Document Server

    Cong, Wenxiang; Wang, Ge

    2013-01-01

    The phosphor nanoparticles made of doped semiconductors, pre-excited by well-collimated X-ray radiation, were recently reported for their light emission upon NIR light stimulation. The characteristics of X-ray energy storage and NIR stimulated emission is highly desirable to design targeting probes and improve molecular and cellular imaging. Here we propose stored luminescence computed tomography (SLCT), perform realistic numerical simulation, and demonstrate a much-improved spatial resolution in a preclinical research context. The future opportunities are also discussed along this direction.

  13. Shopping in discount stores

    DEFF Research Database (Denmark)

    Zielke, Stephan

    2014-01-01

    This paper analyzes the impact of price-related attributions, emotions and value perception on the intention to shop at grocery discounters in an integrated framework. Moderating effects of price consciousness are also analyzed. The results show that the proposed model explains almost three...... quarters of intentions to shop in discount stores. Value perception has the strongest total effect, which is partly mediated by enjoyment, shame and guilt. Attributions influence the shopping intention indirectly via value perception and emotions. The inferior quality attribution has the strongest total...

  14. Store manager performance and satisfaction: effects on store employee performance and satisfaction, store customer satisfaction, and store customer spending growth.

    Science.gov (United States)

    Netemeyer, Richard G; Maxham, James G; Lichtenstein, Donald R

    2010-05-01

    Based on emotional contagion theory and the value-profit chain literatures, the present study posits a number of hypotheses that show how managers in the small store, small number of employees retail context may affect store employees, customers, and potentially store performance. With data from 306 store managers, 1,615 store customer-contact employees, and 57,656 customers of a single retail chain, the authors examined relationships among store manager job satisfaction and job performance, store customer-contact employee job satisfaction and job performance, customer satisfaction with the retailer, and a customer-spending-based store performance metric (customer spending growth over a 2-year period). Via path analysis, several hypothesized direct and interaction relations among these constructs are supported. The results suggest implications for academic researchers and retail managers.

  15. Queues, stores, and tableaux

    CERN Document Server

    Draief, Moez; O'Connell, Neil

    2005-01-01

    Consider the single server queue with an infinite buffer and a FIFO discipline, either of type M/M/1 or Geom/Geom/1. Denote by A the arrival process and by s the services. Assume the stability condition to be satisfied. Denote by D the departure process in equilibrium and by r the time spent by the customers at the very back of the queue. We prove that (D,r) has the same law as (A,s) which is an extension of the classical Burke Theorem. In fact, r can be viewed as the departures from a dual storage model. This duality between the two models also appears when studying the transient behavior of a tandem by means of the RSK algorithm: the first and last row of the resulting semi-standard Young tableau are respectively the last instant of departure in the queue and the total number of departures in the store.

  16. Tobacco advertising in retail stores.

    Science.gov (United States)

    Cummings, K M; Sciandra, R; Lawrence, J

    1991-01-01

    Recent studies have described tobacco advertising in the print media, on billboards, and through sponsorship of cultural and sporting events. However, little attention has been given to another common and unavoidable source of tobacco advertising, that which is encountered in retail stores. In July 1987, we conducted a survey of 61 packaged goods retail stores in Buffalo, NY, to assess the prevalence and type of point-of-sale tobacco advertising. In addition, store owners or managers were surveyed to determine their store's policy regarding tobacco advertising, receipt of monetary incentives from distributors for displaying tobacco ads, and willingness to display antitobacco ads. Six types of stores were involved in the study: 10 supermarkets, 10 privately owned grocery stores, 9 chain convenience food stores that do not sell gasoline, 11 chain convenience food stores that sell gasoline, 11 chain pharmacies, and 10 private pharmacies. Two-thirds of the stores displayed tobacco posters, and 87 percent had promotional items advertising tobacco products, primarily cigarettes. Larger stores, and those that were privately owned, tended to display more posters and promotional items. Eighty percent of tobacco product displays were for cigarettes, 16 percent for smokeless tobacco products, and 4 percent for cigars and pipe tobacco. Convenience stores selling gasoline had the most separate tobacco product displays. Of tobacco product displays, 24 percent were located adjacent to candy and snack displays. Twenty-nine of the 61 store owners or managers indicated that their store had a policy regulating the display of tobacco ads and tobacco product displays. Policies dealt primarily with the location of tobacco posters (for example, no ads in the window) and number of product displays. Only 14 shop owners or managers indicated that they had previously displayed antitobacco information; more than half (31 of 61) said that they would be willing to display antitobaccoads.In many

  17. Small store presence in Japan

    NARCIS (Netherlands)

    M.A. Carree (Martin); J.C.A. Potjes; A.R. Thurik (Roy)

    1993-01-01

    textabstractThe determinants of the development of small store presence in Japan are investigated using a fixed effects multinomial logit market share model. Large stores tend to have higher market shares in shop-types with increasing shares in consumer expenditures, increasing inventory turnover, a

  18. Are You Storing Food Safely?

    Science.gov (United States)

    ... should be stored in tight containers. With commercially frozen foods, it's important to follow the cooking instructions on ... It appears as grayish-brown leathery spots on frozen food. It can occur when food is not securely ...

  19. Information from the central stores

    CERN Multimedia

    GS Department

    2010-01-01

    All items sold in the CERN shop (Bldg. 33) are now available in the central stores (Bldg. 73) and can be purchased on-line via EDH “Material Request” or at the “Emergency Desk” of the stores on the ground floor of Bldg. 73. These items are visible in the CERN catalogue under the “SCEM” codes beginning with 92. Department of General Infrastructure Services (GS) GS-SEM Group

  20. Stores, Weight and Inertial System Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This facility provides stores weight, center of gravity, and inertia measurements in support of weapon/aircraft compatibility testing. System provides store weight...

  1. Storing XML Documents in Databases

    NARCIS (Netherlands)

    Schmidt, A.R.; Manegold, S.; Kersten, M.L.; Rivero, L.C.; Doorn, J.H.; Ferraggine, V.E.

    2005-01-01

    The authors introduce concepts for loading large amounts of XML documents into databases where the documents are stored and maintained. The goal is to make XML databases as unobtrusive in multi-tier systems as possible and at the same time provide as many services defined by the XML standards as pos

  2. Decoupler pylon: wing/store flutter suppressor

    Science.gov (United States)

    Reed, W. H., III (Inventor)

    1982-01-01

    A device for suspending a store from a support such as an aircraft wing and more specifically for increasing the flutter speed of an aircraft flying with attached store and reducing the sensitivity of flutter to changes in the pitch inertia and center of gravity location of the store is described. It comprises softspring where the store pitch mode is decoupled from support modes and a low frequency active control mechanism which maintains store alignment. A pneumatic suspension system both isolates the store in pitch and, under conditions of changing mean load, aligns the store with the wing to which it is attached.

  3. Store-Operated Calcium Channels.

    Science.gov (United States)

    Prakriya, Murali; Lewis, Richard S

    2015-10-01

    Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in virtually all metozoan cells and serve a wide variety of functions ranging from gene expression, motility, and secretion to tissue and organ development and the immune response. SOCs are activated by the depletion of Ca(2+) from the endoplasmic reticulum (ER), triggered physiologically through stimulation of a diverse set of surface receptors. Over 15 years after the first characterization of SOCs through electrophysiology, the identification of the STIM proteins as ER Ca(2+) sensors and the Orai proteins as store-operated channels has enabled rapid progress in understanding the unique mechanism of store-operate calcium entry (SOCE). Depletion of Ca(2+) from the ER causes STIM to accumulate at ER-plasma membrane (PM) junctions where it traps and activates Orai channels diffusing in the closely apposed PM. Mutagenesis studies combined with recent structural insights about STIM and Orai proteins are now beginning to reveal the molecular underpinnings of these choreographic events. This review describes the major experimental advances underlying our current understanding of how ER Ca(2+) depletion is coupled to the activation of SOCs. Particular emphasis is placed on the molecular mechanisms of STIM and Orai activation, Orai channel properties, modulation of STIM and Orai function, pharmacological inhibitors of SOCE, and the functions of STIM and Orai in physiology and disease.

  4. An investigation of Consumer Specialty Store and Multi-Brand Store loyalty

    Directory of Open Access Journals (Sweden)

    Sarabjot Singh

    2013-10-01

    Full Text Available In the competitive era of retailing, retailers need to understand the importance of store format preferences. The study aimed to understand consumer store loyalty, in-depth interview is conducted to examine consumer store loyalty antecedents for two retail formats: specialty stores and multi brand stores. The study conceptualizes store loyalty factors like program loyalty, trust and brand commitment. Trust and brand commitment act as a mediating factors between storeimage and store loyalty formats, and also between brand image and store loyalty formats. The findings highlight how consumer store loyalty preference changes for these two formats.

  5. EVALUATING FACTORS INFLUENCING GROCERY STORE CHOICE

    OpenAIRE

    Palma, Marco A.; Emerson, Robert D.; House, Lisa

    2003-01-01

    This paper analyzes consumer preferences toward grocery store choices given a set of attributes of stores. This information will then be used to make inferences on how the opening of a Wal-Mart supercenter would affect the other grocery stores in a small city.

  6. PET/T.D.M. with {sup 18}FDG in the vesicle tumors; TEP/TDM au {sup 18}FDG dans les tumeurs vesicales

    Energy Technology Data Exchange (ETDEWEB)

    De Clermont-Gallerande, H.; Laffon, E.; Allard, M.; Fernandez, P. [Universite Victor-Segalen Bordeaux-2, (France); Godbert, Y. [service de medecine nucleaire, pole d' imagerie, CHRU de Bordeaux, (France); Wallerand, H. [service d' urologie, pole de chirurgie, CHRU de Bordeaux, (France); Ravaud, A. [service d' oncologie medicale et radiotherapie, pole d' oncologie, CHRU de Bordeaux, (France)

    2009-05-15

    The aim of this study was to evaluate the PET/T.D.M. with 18 F.D.G. with a hyper diuresis protocol in the initial evaluation of the vesicle tumors. After results, it appears that the PET/T.D.M. with 18 F.D.G. has an excellent diagnosis performance in the evaluation of vesicle tumors and could have a prognosis interest. These results are to be confirmed. (N.C.)

  7. Consumer evaluations of store brands: effects of store image and product attributes

    OpenAIRE

    Semeijn, J.; van Riel, A.C.R.; Ambrosini, A.B.

    2003-01-01

    Store brands have grown in importance. Large numbers of products carrying a store label have been introduced in recent years, with varying degrees of success. It appears that retailers pay little attention to the multiple risks associated with adding new product categories to their store labels. In this study we investigate how attributes of store and product affect consumer evaluations of store branded products. A structural model is developed and tested, indicating the likelihood of success...

  8. Mechanism of store-operated calcium entry

    Indian Academy of Sciences (India)

    Devkanya Dutta

    2000-12-01

    Activation of receptors coupled to the phospholipase C/IP3 signalling pathway results in a rapid release of calcium from its intracellular stores, eventually leading to depletion of these stores. Calcium store depletion triggers an influx of extracellular calcium across the plasma membrane, a mechanism known as the store-operated calcium entry or capacitative calcium entry. Capacitative calcium current plays a key role in replenishing calcium stores and activating various physiological processes. Despite considerable efforts, very little is known about the molecular nature of the capacitative channel and the signalling pathway that activates it. This review summarizes our current knowledge about store operated calcium entry and suggests possible hypotheses for its mode of activation.

  9. Maintaining Stored Procedures in Database Application

    Directory of Open Access Journals (Sweden)

    Santosh Kakade

    2012-06-01

    Full Text Available Stored procedure and triggers have an irreplaceable importance in any database application, as they provide a powerful way to code application logic that can be stored on the server and execute according to the need of application. Writing stored procedures for database application involves set of sql statements with an assigned name that's stored in the database in compiled form so that it can be shared by a number of programs. The use of stored procedures can be helpful in controlling access to data end-users may enter or change data but do not write procedures, preserving data integrity and improving productivity statements in a stored procedure only need to be written one time

  10. Mass Retailers' Advertising Strategies Against Commodity Stores.

    OpenAIRE

    Fabian Bergès; Sylvette Monier-Dilhan

    2013-01-01

    A retailer has different opportunities to advertise in the media: emphasizing the store image or promoting specifically its private label (PL). In the first option, advertising benefits all products sold, whereas in the alternative, only store brands are concerned by image improvement. We analyze the retailer's advertising campaign strategies when its competitor's format is a small commodity store. PL quality is endogenous and chosen according to the competitor's product range. We show the re...

  11. Signature-based store checking buffer

    Science.gov (United States)

    Sridharan, Vilas; Gurumurthi, Sudhanva

    2015-06-02

    A system and method for optimizing redundant output verification, are provided. A hardware-based store fingerprint buffer receives multiple instances of output from multiple instances of computation. The store fingerprint buffer generates a signature from the content included in the multiple instances of output. When a barrier is reached, the store fingerprint buffer uses the signature to verify the content is error-free.

  12. Distributed energy store railgun; The limiting case

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, R.A. (WBM Stalker Pty. Ltd., 99 Leichardt Street, Brisbane, Qld. (AU))

    1991-01-01

    This paper reports that when the limiting case of a distributed energy store railgun is analyzed, i.e., the case where the space between adjacent energy stores become indefinitely small, three important results are obtained. First, the shape of the current pulse delivered by each store is sinusoidal and an exponential tail. Second, the rail-to-rail voltage behind the rear-most active store approaches zero. Third, it is not possible to choose parameters in such a way that capacitor crowbars can be eliminated.

  13. Building Store Satisfaction Centred on Customer Retention in Clothing Retailing: Store Design and Ease of Shopping

    Directory of Open Access Journals (Sweden)

    Gulden Turhan

    2016-01-01

    Full Text Available The study’s research model suggests that store design and ease of shopping are associated with customer retention through a mediated pathway in which store design and ease of shopping influence perceived store satisfaction, which in turn, influences customer retention. This survey was administered to two separate clothing stores offered to either females or males (in total, 533 participants. Using structural equation modelling methodology, data was analysed to explain the interrelations among the variables in the model. The results of an empirical study of a sample of store shoppers revealed that store design and ease of shopping influence customer retention in an indirect way through customer perception of satisfaction with the store. In building store satisfaction that is centred on customer retention, store design and shopping ease differ in their relative influences. This difference is high for females, but for men as low as to be considered negligible in males. As a result, improving customers’ perceptions of store design and ease of shopping is a way to ensure store satisfaction support customer retention. The results of the study provide a new insight into the relationships by suggesting indirect effects of shopping ease and store design on consumer retention by their impacts on store satisfaction, rather than direct effects.

  14. Retail brand architecture and consumer store loyalty

    DEFF Research Database (Denmark)

    Brunsø, Karen; Grunert, Klaus G.

    is to investigate the relationship between consumers perceived retail brand architecture, their store satisfaction and loyalty. Furthermore we use perceived store image as a mediating factor in our framework. In total 772 Danish households participated in a telephone interview and returned questionnaires by mail...

  15. Win-Win Strategies at Discount Stores

    NARCIS (Netherlands)

    B. Deleersnyder (Barbara); M.G. Dekimpe (Marnik); J-B.E.M. Steenkamp (Jan-Benedict); O. Koll

    2005-01-01

    textabstractAn important development that contributes to store brands’ growing success in the grocery market is the increasing number of discount stores that sell predominantly own, private-label, brands. To fight private labels, manufacturers of national brands feel increasingly compelled to develo

  16. Consumers' store choice behavior for fresh food

    NARCIS (Netherlands)

    Meulenberg, M.T.G.; Trijp, van J.C.M.

    1991-01-01

    Consumers' preference for fresh food stores is analyzed. In particular the choice between supermarkets and specialized shops for purchasing fresh food is analyzed. Attention is given to the factors influencing this choice. For this purpose a number of research questions with respect to store choice

  17. Store-operate-coherence-on-value

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Dong; Heidelberger, Philip; Kumar, Sameer; Ohmacht, Martin; Steinmacher-Burow, Burkhard

    2014-11-18

    A system, method and computer program product for performing various store-operate instructions in a parallel computing environment that includes a plurality of processors and at least one cache memory device. A queue in the system receives, from a processor, a store-operate instruction that specifies under which condition a cache coherence operation is to be invoked. A hardware unit in the system runs the received store-operate instruction. The hardware unit evaluates whether a result of the running the received store-operate instruction satisfies the condition. The hardware unit invokes a cache coherence operation on a cache memory address associated with the received store-operate instruction if the result satisfies the condition. Otherwise, the hardware unit does not invoke the cache coherence operation on the cache memory device.

  18. Consumers' quality perception of national branded, national store branded, and imported store branded beef

    DEFF Research Database (Denmark)

    Banovic, Marija; Grunert, Klaus G.; Barreira, Maria Madalena;

    2010-01-01

    This study investigated the differences in the consumers' quality perception of national branded, national store branded, and imported store branded beef. Partial Least Squares analysis is used for modelling the quality perception process. Results show that consumers perceived national branded...

  19. NASA Armstrong's Approach to Store Separation Analysis

    Science.gov (United States)

    Acuff, Chris; Bui, Trong

    2015-01-01

    Presentation will an overview of NASA Armstrong's store separation capabilities and how they have been applied recently. Objective of the presentation is to brief Generation Orbit and other potential partners on NASA Armstrong's store separation capabilities. It will include discussions on the use of NAVSEP and Cart3D, as well as some Python scripting work to perform the analysis, and a short overview of this methodology applied to the Towed Glider Air Launch System. Collaboration with potential customers in this area could lead to funding for the further development of a store separation capability at NASA Armstrong, which would boost the portfolio of engineering expertise at the center.

  20. Human Resources Operational Data Store Core Services

    Data.gov (United States)

    Social Security Administration — This database contains only a very small subset of the Human Resources Operational Data Store data. It supports the SSA Employee and Office Data Retrieval (SEODR)...

  1. Infant Formula - Buying, Preparing, Storing, and Feeding

    Science.gov (United States)

    ... 000806.htm Infant Formula – Buying, Preparing, Storing, and Feeding To use the sharing features on this page, ... brush to get at hard-to-reach places. Feeding Formula to Baby Here is a guide to ...

  2. 7 CFR 1170.6 - Store.

    Science.gov (United States)

    2010-01-01

    ... means to place nonfat dry milk or dry whey in a manufacturing plant, packaging plant, distribution point... Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PRODUCT MANDATORY REPORTING § 1170.6 Store. (a)...

  3. A Better Reduction Theorem for Store Buffers

    CERN Document Server

    Cohen, Ernie

    2009-01-01

    When verifying a concurrent program, it is usual to assume that memory is sequentially consistent. However, most modern multiprocessors depend on store buffering for efficiency, and provide native sequential consistency only at a substantial performance penalty. To regain sequential consistency, a programmer has to follow an appropriate programming discipline. However, na\\"ive disciplines, such as protecting all shared accesses with locks, are not flexible enough for building high-performance multiprocessor software. We present a new discipline for concurrent programming under TSO (total store order, with store buffer forwarding). It does not depend on concurrency primitives, such as locks. Instead, threads use ghost operations to acquire and release ownership of memory addresses. A thread can write to an address only if no other thread owns it, and can read from an address only if it owns it or it is shared and the thread has flushed its store buffer since it last wrote to an address it did not own. This dis...

  4. Stored energy in irradiated silicon carbide

    Energy Technology Data Exchange (ETDEWEB)

    Snead, L.L.; Burchell, T.D. [Oak Ridge National Lab., TN (United States)

    1997-04-01

    This report presents a short review of the phenomenon of Wigner stored energy release from irradiated graphite and discusses it in relation to neutron irradiation of silicon carbide. A single published work in the area of stored energy release in SiC is reviewed and the results are discussed. It appears from this previous work that because the combination of the comparatively high specific heat of SiC and distribution in activation energies for recombining defects, the stored energy release of SiC should only be a problem at temperatures lower than those considered for fusion devices. The conclusion of this preliminary review is that the stored energy release in SiC will not be sufficient to cause catastrophic heating in fusion reactor components, though further study would be desirable.

  5. Automatic Segmentation of Lung Carcinoma Using 3D Texture Features in 18-FDG PET/CT

    Directory of Open Access Journals (Sweden)

    Daniel Markel

    2013-01-01

    Full Text Available Target definition is the largest source of geometric uncertainty in radiation therapy. This is partly due to a lack of contrast between tumor and healthy soft tissue for computed tomography (CT and due to blurriness, lower spatial resolution, and lack of a truly quantitative unit for positron emission tomography (PET. First-, second-, and higher-order statistics, Tamura, and structural features were characterized for PET and CT images of lung carcinoma and organs of the thorax. A combined decision tree (DT with K-nearest neighbours (KNN classifiers as nodes containing combinations of 3 features were trained and used for segmentation of the gross tumor volume. This approach was validated for 31 patients from two separate institutions and scanners. The results were compared with thresholding approaches, the fuzzy clustering method, the 3-level fuzzy locally adaptive Bayesian algorithm, the multivalued level set algorithm, and a single KNN using Hounsfield units and standard uptake value. The results showed the DTKNN classifier had the highest sensitivity of 73.9%, second highest average Dice coefficient of 0.607, and a specificity of 99.2% for classifying voxels when using a probabilistic ground truth provided by simultaneous truth and performance level estimation using contours drawn by 3 trained physicians.

  6. Radiation exposure to surgical staff during F-18-FDG-guided cancer surgery

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, P.A.; Hesse, B. [Copenhagen University Hospital, Department of Clinical Physiology and Nuclear Medicine, Copenhagen (Denmark); Chakera, A.H.; Schmidt, G. [Copenhagen University Hospital, Department of Plastic Surgery and Burn Unit, Copenhagen (Denmark); Klausen, T.L. [Herlev University Hospital, Department of Clinical Physiology and Nuclear Medicine, Herlev (Denmark); Binderup, T. [University of Copenhagen, Cluster for Molecular Imaging, Department of Biomedical Sciences, Copenhagen (Denmark); Grossjohann, H.S. [Section of Ultrasound, Copenhagen University Hospital, Department of Radiology, Copenhagen (Denmark); Friis, E. [Copenhagen University Hospital, Department of Breast and Endocrine Surgery, Copenhagen (Denmark); Hansen, C.P. [Copenhagen University Hospital, Department of Abdominal Surgery, Copenhagen (Denmark); Kjaer, A. [Copenhagen University Hospital, Department of Clinical Physiology and Nuclear Medicine, Copenhagen (Denmark); University of Copenhagen, Cluster for Molecular Imaging, Department of Biomedical Sciences, Copenhagen (Denmark)

    2008-03-15

    High-energy gamma probes have recently become commercially available, developed for {sup 18}F-FDG probe-guided surgery. The radiation received by the staff in the operating room might limit the use of it, but has never been determined. We therefore wanted to measure the absorbed staff doses at operations where patients had received a preoperative injection of {sup 18}F-FDG. Thirty-four patients with different cancers (breast cancer, melanoma, gastrointestinal cancers, respectively) were operated. At every operation the surgeon was monitored with a TLD tablet on his finger of the operating hand and a TLD tablet on the abdomen. The surgeon and anaesthesiologist were also monitored using electronic dosimeters placed in the trousers lining at 25 operations. The dose rate to the surgeon's abdominal wall varied between 7.5-13.2 {mu}Sv/h, depending on tumour location. The doses to the anaesthesiologists and the finger doses to the surgeon were much lower. About 350-400 MBq, i.e. ca. eight times higher activities than those used in the present study are supposed to be necessary for guiding surgery. It can be calculated from the body doses measured that a surgeon can perform between 150-260 h of surgery without exceeding permissible limits for professional workers. The radiation load to the operating staff will generally be so small that it does not present any limitation for FDG-guided surgery. However, it is recommended to monitor the surgical staff considering that the surgeon may be exposed to other radiation sources, and since the staff often includes women of child-bearing age. (orig.)

  7. F-18 FDG PET/CT imaging of primary hepatic neuroendocrine tumor

    Directory of Open Access Journals (Sweden)

    Katsuya Mitamura

    2015-01-01

    Full Text Available Primary hepatic neuroendocrine tumors (PHNETs are extremely rare neoplasms. Herein, we report a case of a 70-year-old man with a hepatic mass. The non-contrast computed tomography (CT image showed a low-density mass, and dynamic CT images indicated the enhancement of the mass in the arterial phase and early washout in the late phase. F18- fluorodeoxyglucose (18F-FDG positron emission tomography (PET and fused PET/CT images showed increased uptake in the hepatic mass. Whole-body 18F-FDG PET images showed no abnormal activity except for the liver lesion. Presence of an extrahepatic tumor was also ruled out by performing upper gastrointestinal endoscopy, total colonoscopy, and chest and abdominal CT. A posterior segmentectomy was performed, and histologic examination confirmed a neuroendocrine tumor (grade 1. The patient was followed up for about 2 years after the resection, and no extrahepatic lesions were radiologically found. Therefore, the patient was diagnosed with PHNET. To the best of our knowledge, no previous case of PHNET have been detected by 18F-FDG PET imaging.

  8. Neural responses of rats in the forced swimming test: [F-18]FDG micro PET study.

    Science.gov (United States)

    Jang, Dong-Pyo; Lee, So-Hee; Lee, Sang-Yoon; Park, Chan-Woong; Cho, Zang-Hee; Kim, Young-Bo

    2009-10-12

    The forced swimming test (FST) is a widely used tool in the assessment of behavioral despair and prediction of response to antidepressants. However, the neural mechanisms underlying behavioral changes between pretest and test sessions of the FST remain unclear. In this study, we investigated changes in rat brain activity during the FST using [F-18]Fluorodeoxyglucose micro PET. In both pretest and test sessions, the activity of the cerebellum and striatum increased, whereas significant deactivation was observed in the hippocampus, inferior colliculus, orbital cortex, and insula. The periaqueductal gray (PAG) region activated markedly in the pretest session, but did not activate in the test session. There was a significant increase in immobility and a decrease in climbing during the behavioral analysis test session. These results suggest that the PAG region may play an important role in the modulation of FST coping strategies subsequent to failure of the escape response during the pretest session.

  9. Magnetically driven nanoparticles: (18) FDG-radiolabelling and positron emission tomography biodistribution study.

    Science.gov (United States)

    De Simone, Mariarosaria; Panetta, Daniele; Bramanti, Emilia; Giordano, Cristiana; Salvatici, Maria C; Gherardini, Lisa; Menciassi, Arianna; Burchielli, Silvia; Cinti, Caterina; Salvadori, Piero A

    2016-11-01

    Superparamagnetic iron oxide nanoparticles (SPIONs) have received increasing interest as contrast media in biomedical imaging and innovative therapeutic tools, in particular for loco-regional ablative treatments and drug delivery. The future of therapeutic applications would strongly benefit from improving the capability of the nanostructured constructs to reach the selected target, in particular beyond the intravascular space. Besides the decoration of SPIONs surface with ad hoc bioactive molecules, external magnetic fields are in principle able to remotely influence SPIONs' physiological biodistribution and concentrate them to a specific anatomical region or portion of a tissue. The reduction of SPIONs administered to the body and the need for defining the effective SPIONs local concentration suggest that PET/CT may be a method to quantitatively detect the nanoparticles accumulation in vivo at low concentration and assess their tridimensional distribution in response to an external magnetic field and in relation to the local anatomy highlighted by CT imaging. Here, we report on the possibility to assess the spatial distribution of magnetically-driven radiolabelled SPIONs in a peripheral tissue (mouse thigh) with microPET/CT imaging. To this aim we labelled SPIONs using (18) F-2-fluoro-2-deoxyglucose as a synthon, by chemoselective oxime formation between its open-chain tautomer and nanoparticle amino-groups, and employed microPET/CT imaging to measure the radiolabelled construct biodistribution in a small animal model, following intravenous administration, with and without the application of a permanent magnet onto the skin. The in vivo and ex vivo results showed that micro-PET/CT was able to demonstrate the localizing action of the magnet on SPIONs and provide information, in a multimodal 3D data set, about SPIONs biodistribution taking into account the local anatomy. Copyright © 2017 John Wiley & Sons, Ltd.

  10. Utility of 18FDG-PET/CT in breast cancer diagnostics--a systematic review

    DEFF Research Database (Denmark)

    Warning, Karina; Hildebrandt, Malene Grubbe; Kristensen, Bent;

    2011-01-01

    as a primary diagnostic procedure in breast cancer; but it has the potential to be useful for the detection of distant metastases and for monitoring response to chemotherapy in breast cancer patients. PET/CT should still be regarded as a supplement to conventional diagnostic procedures such as CT and MRI....

  11. Detection of penile metastasis from bladder cancer using F 18 FDG PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Dong Yun; Lee, Jong Jin [Univ. of Ulsan College of Medicine, Seoul (Korea, Republic of)

    2012-12-15

    A 74 year old man who had experienced priapism for 2 months after radical cystectomy for bladder cancer visited our hospital, and underwent metastatic work up {sup 18}F fluorodeoxyglucose (FDG) positron emission tomography/computed tomography(PET/CT)showed diffuse hypermetabolic activity along the penis shaft, which was confirmed as a penile metastasis.

  12. Incidentally detected carcinoma ex pleomorphic adenoma of parotid gland by F-18 FDG PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Kong, Eun Jung; Chun, Kyung Ah; Cho, Ihn Ho [Yeungnam Univ. Hospital, Daegu (Korea, Republic of)

    2016-03-15

    A 62-year-old man underwent FDG PET/CT to determine the initial stage of gastric carcinoma, and the scan revealed an incidental FDG-avid mass in the left parotid gland. He subsequently underwent surgery, and the final diagnosis was of carcinoma ex pleomorphic adenoma with cervical lymph node metastasis. The patient underwent left total parotidectomy with left selective neck dissection 2 months later, and the histopathologic report confirmed carcinoma ex pleomorphic adenoma with cervical lymph node metastasis.

  13. Role of F-18 FDG PET/CT imaging in the diagnosis of paraneoplastic neurological syndromes

    Institute of Scientific and Technical Information of China (English)

    Lei Kang; Xiaojie Xu; Hongwei Sun; Rongfu Wang

    2014-01-01

    Paraneoplastic neurological syndromes (PNS) is a series of rare neurologic disorders which happen with an underlying malignancy. It has various clinical symptoms proceding to the diagnosis of tumors. Although the abnormality of anti-neuronal antibodies is suggestive of PNS and tumors, there exist many false positive and false negative cases. The diagnosis of PNS is usualy a chalenge in clinic. Positron emission tomography/computed tomography (PET/CT) imaging is an anatomical and functional fusion imaging method, which provides the whole-body information by single scan. Fluorodeoxy-glucose (FDG) PET/CT imaging can not only detect potential malignant lesions in the whole body, but also assess functional abnormality in the brain. In this review, the mechanism, clinical manifestation, diagnostic procedure and the recent progress of the utility of FDG PET/CT in PNS are introduced respectively.

  14. Extensive Invasive Extramammary Paget Disease Evaluated by F-18 FDG PET/CT

    OpenAIRE

    Li, Zu-Gui; Qin, Xiao-Jing

    2015-01-01

    Abstract Extramammary Paget disease (EMPD) is a rare cutaneous, intraepithelial adenocarcinoma. Because of its rarity, little is known about the value of fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in evaluating this disease. Our case report aims to increase current knowledge of FDG PET/CT in EMPD as a noninvasive imaging tool for assessing the extension of the disease and detecting distant metastases. We reported a 64-year-old Chinese man who presented ...

  15. Extensive Invasive Extramammary Paget Disease Evaluated by F-18 FDG PET/CT

    Science.gov (United States)

    Li, Zu-Gui; Qin, Xiao-Jing

    2015-01-01

    Abstract Extramammary Paget disease (EMPD) is a rare cutaneous, intraepithelial adenocarcinoma. Because of its rarity, little is known about the value of fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in evaluating this disease. Our case report aims to increase current knowledge of FDG PET/CT in EMPD as a noninvasive imaging tool for assessing the extension of the disease and detecting distant metastases. We reported a 64-year-old Chinese man who presented with a slowly progressive, ill-margined erythematous lesion with a crusted, eroded, and scaly surface involving multiple sites of penis, scrotum, left pelvic wall, hip, groin, and thigh for >4 years, which became extensive in the past 1 year. He was referred for an FDG PET/CT examination to further evaluate the lesions. A following skin biopsy was performed to obtain a definitive histological diagnosis. FDG PET/CT imaging revealed mild FDG uptake at the extensive cutaneous lesion with subcutaneous invasion, involvement of lymph nodes, and multiple intense FDG-avid of skeletal metastases. According to the appearance of FDG PET/CT, a provisional diagnosis of advanced cutaneous malignancy was made. Histopathology findings indicated characteristic of EMPD. The patient was treated with radiation therapy and died from complications 2 months after the last dose of radiotherapy. Our case highlighted that a whole-body FDG PET/CT should be incorporated into the diagnostic algorithm of EMPD to give a comprehensive assessment of this disease. PMID:25621679

  16. Extensive invasive extramammary Paget disease evaluated by F-18 FDG PET/CT: a case report.

    Science.gov (United States)

    Li, Zu-Gui; Qin, Xiao-Jing

    2015-01-01

    Extramammary Paget disease (EMPD) is a rare cutaneous, intraepithelial adenocarcinoma. Because of its rarity, little is known about the value of fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in evaluating this disease. Our case report aims to increase current knowledge of FDG PET/CT in EMPD as a noninvasive imaging tool for assessing the extension of the disease and detecting distant metastases.We reported a 64-year-old Chinese man who presented with a slowly progressive, ill-margined erythematous lesion with a crusted, eroded, and scaly surface involving multiple sites of penis, scrotum, left pelvic wall, hip, groin, and thigh for >4 years, which became extensive in the past 1 year. He was referred for an FDG PET/CT examination to further evaluate the lesions. A following skin biopsy was performed to obtain a definitive histological diagnosis.FDG PET/CT imaging revealed mild FDG uptake at the extensive cutaneous lesion with subcutaneous invasion, involvement of lymph nodes, and multiple intense FDG-avid of skeletal metastases. According to the appearance of FDG PET/CT, a provisional diagnosis of advanced cutaneous malignancy was made. Histopathology findings indicated characteristic of EMPD. The patient was treated with radiation therapy and died from complications 2 months after the last dose of radiotherapy.Our case highlighted that a whole-body FDG PET/CT should be incorporated into the diagnostic algorithm of EMPD to give a comprehensive assessment of this disease.

  17. Neurolymphomatosis on F 18 FDG PET/CT and MRI Findings: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Chae Moon; Lee, Sang Woo; Lee, Hong Je; Song, Bong Il; Kim, Hae Won; Kang, Sungmin; Jeong, Shin Young; Ahn, Byeong Cheol; Lee, Jaetae; Chae, Yee Soo [Kyungpook National Univ. Hospital, Daegu (Korea, Republic of)

    2011-03-15

    Neurolymphomatosis is a rare manifestation of malignant lymphoma. A 74 year old man, in complete remission from diffuse large B cell lymphoma, presented with a loss of pain and temperature sensation in the left hemiface and left upper extremity, and motor weakness in the left upper and both lower extremities. Cerebrospinal fluid analysis and brain magnetic resonance imaging (MRI) findings were negative. Combined fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) revealed multiple linear hypermetabolic lesions along the mandibular branch of the left trigeminal nerve, left brachial plexus, right adrenal gland, right femoral nerve, and both sciatic nerves, which corresponded to the patient's complex neurologic symptoms. C spine and pelvic MRI revealed diffuse thickening with enhancement in the left sciatic nerve, but negative findings for other sites identified by FDG PET/CT. These findings for other sites identified by FDG PET/CT. These findings suggest that FDG PET/CT can detect peripheral nerve infiltration by malignant lymphoma earlier than MRI. Thus, if a patient with a history of lymphoma presents with neurologic symptoms, FDG PET/CT should be performed to evaluate neurolymphomatosis.

  18. Challenges in integrating 18FDG PET-CT into radiotherapy planning of head and neck cancer.

    Science.gov (United States)

    Dandekar, P; Partridge, M; Kazi, R; Nutting, C; Harrington, K; Newbold, K

    2010-01-01

    Radiotherapy forms one of the major treatment modalities for head and neck cancers (HNC), and precision radiotherapy techniques, such as intensity-modulated radiotherapy require accurate target delineation to ensure success of the treatment. Conventionally used imaging modalities, such as X-ray computed tomography (CT) and magnetic resonance imaging are used to delineate the tumor. Imaging, such as positron emission tomography (PET)-CT, which combines the functional and anatomic modalities, is increasingly being used in the management of HNC. Currently, 18-fluorodeoxyglucose is the most commonly used radioisotope, which is accumulated in areas of high glucose uptake, such as the tumor tissue. Because most disease recurrences are within the high-dose radiotherapy volume, defining a biological target volume for radiotherapy boost is an attractive approach to improve the results. There are many challenges in employing the PET-CT for radiotherapy planning, such as patient positioning, target edge definition, and use of new PET tracers, which represent various functional properties, such as hypoxia, protein synthesis, and proliferation. The role of PET-CT for radiotherapy planning is ever expanding and more clinical data underlining the advantages and challenges in this approach are emerging. In this article, we review the current clinical evidence for the application of functional imaging to radiotherapy planning and discuss some of the current challenges and possible solutions that have been suggested to date.

  19. Value of F-18 FDG hybrid camera PET and MRI in early takayasu aortitis

    Energy Technology Data Exchange (ETDEWEB)

    Meller, J.; Becker, W. [Department of Nuclear Medicine, Georg August University, Robert Koch Strasse 40, 37075 Goettingen (Germany); Grabbe, E.; Vosshenrich, R. [Department of Radiology, Georg August University, Robert Koch Strasse 40, 37075 Goettingen (Germany)

    2003-02-01

    Takayasu aortitis (TA) is a chronic inflammatory and fibrotic vasculitis of large- and medium-sized arteries. Early stages of the disease show a panarteritis and inflammatory wall thickening of the aorta and its branches, whereas advanced (fibrotic) stages comprise stenosis, aneurismatic transformation and occlusion. Magnetic resonance imaging visualises early-stage disease with high accuracy and is considered to be the method of choice in the diagnosis of TA. The aim of this article is the detailed comparison of FDG-PET performed with a hybrid camera and MR imaging in five patients with early TA. Five patients (median age 60 years) were enrolled during an ongoing prospective study on [18F]2'-deoxy-2-fluoro-D-glucose (FDG) hybrid camera PET in patients with fever of unknown origin (FUO). These patients underwent MR imaging after establishing the diagnosis of TA. Abnormal FDG uptake in the wall of the aorta was noted in all patients. The bracheocephalic artery and the common carotid arteries were visualized in 3 cases. Increased uptake of the subclavian artery was found in 3 patients and in 4 patients pathological uptake was noted in the ilio-femoral vessels. Of 34 vascular regions studied, 26 (76%) showed elevated FDG uptake. On transversal MR images vessel wall thickening and contrast enhancement of the thoracic aorta was found in 4 patients (ascending aorta/aortic arch: n=2; descending aorta: n=3; abdominal aorta: n=1). Additionally, vessel wall pathologies of the subclavian and the common carotid arteries could be shown in 1 patient and in another patient in the ilio-femoral arteries. No abnormalities were found using contrast-enhanced MR angiography. Of 28 vascular regions studied, 9 (32%) showed vasculitis on MRI. The FDG-PET is a suitable whole-body screening method in the primary diagnosis of early TA, especially in those cases with early disease that present with uncharacteristic symptoms such as FUO. Both MRI and MRA remain indispensable in the exact determination of the pathomorphological changes and in the documentation of complications such as stenosis, aneurismatic transformation and occlusion. (orig.)

  20. An 18FDG-PET/CT finding of a mediastinal abscess.

    LENUS (Irish Health Repository)

    Purcell, Yvonne Marie

    2013-02-01

    A 66-year-old man with left pyriform fossa squamous cell carcinoma (T2N0) was treated with chemoradiation. Nine months later, an emergency tracheostomy was performed for respiratory distress. Contrast-enhanced neck and thorax CT demonstrated a right pyriform mass. FDG-PET\\/CT showed linear increased uptake extending superiorly from the tracheostomy to the right Eustachian tube and inferiorly to the posterior mediastinum. Postmortem examination confirmed a 7 × 2.2 cm abscess extending from the right parapharyngeal, peritracheal, and prevertebral structures to the mediastinum.

  1. Strategic Marketing Plan For Wedding Store : Case: Golden Crown Wedding Store, China

    OpenAIRE

    Wu, Fan

    2013-01-01

    ABSTRACT Wu, Fan 2012. Strategic Marketing Plan for Golden Crown Wedding Store. Case: Golden Crown Wedding Store, China. Bachelor’s Thesis. Kemi-Tornio University of Applied Sciences. Business and Culture. Pages 39. Appendices 1- 2. The objective of this thesis is to build a strategic marketing plan for the Golden Crown Wedding Store. The strategic marketing plan and the analysis of the situation of the market are the main part of the thesis. This thesis will help the case company to ...

  2. SOC and now also SIC: store-operated and store-inhibited channels.

    Science.gov (United States)

    Moreno, Claudia; Vaca, Luis

    2011-10-01

    There is a specialized form of calcium influx that involves a close communication between endoplasmic reticulum and the channels at the plasma membrane. In one side store depletion activates channels known as store-operated channels (SOC), which are responsible of the well-studied store-operated calcium entry (SOCE). SOC comprises two different types of channels. Orai, which is exclusively activated by store depletion being the channel responsible of the calcium release-activated calcium current, and transient receptor potential canonical channel, which in contrast, is activated by store depletion only under specific conditions and carries nonselective cationic currents. On the other hand, it has been recently shown that store depletion also inhibits calcium channels. The first member identified, of what we named as store-inhibited channels (SIC), is the L-type voltage-gated calcium channel. Stores control both SOC and SIC by means of the multifunctional protein STIM1. The identification of SOC and SIC opens a new scenario for the role of store depletion in the modulation of different calcium entry pathways, which may satisfy different cellular processes.

  3. Entrance Effects in Solar Hot Water Stores

    DEFF Research Database (Denmark)

    Shah, Louise Jivan; Furbo, Simon

    2003-01-01

    A theoretical and experimental analysis of water jets entering a solar storage tank is performed. CFD calculations of three inlet designs with different inlet flow rates were carried out to illustrate the varying behaviour of the thermal conditions in a solar store. The results showed the impact...... of the inlet design on the flow patterns in the tank and thus how the energy quality in a hot water tank is reduced with a poor inlet design. The numerical investigations were followed by experiments. A test solar store, similar to the store investigated by numerical modelling was constructed with cylindrical...... transparent walls so that the flow structures due to the inlet jets could be visualized. With the three inlets, nine draw-off tests with different inlet flow rates were carried out and the temperature stratification in the tank was measured during the draw-offs. The experimental results were used...

  4. Understanding Consumers' In-store Visual Perception

    DEFF Research Database (Denmark)

    Clement, Jesper; Kristensen, Tore; Grønhaug, Kjell

    2013-01-01

    It is widely accepted that the human brain has limited capacity for perceptual stimuli and consumers'' visual attention, when searching for a particular product or brand in a grocery store, should then be limited by the boundaries of their own perceptual capacity. In this exploratory study, we...... examine the relationship between abundant in-store stimuli and limited human perceptual capacity. Specifically, we test the influence of package design features on visual attention. Data was collected through two eye-tracking experiments, one in a grocery store using wireless eye-tracking equipment......, and another in a lab setting. Findings show that consumers have fragmented visual attention during grocery shopping, and that their visual attention is simultaneously influenced and disrupted by the shelf display. Physical design features such as shape and contrast dominate the initial phase of searching...

  5. Spin flipping a stored polarized proton beam

    Science.gov (United States)

    Caussyn, D. D.; Derbenev, Ya. S.; Ellison, T. J.; Lee, S. Y.; Rinckel, T.; Schwandt, P.; Sperisen, F.; Stephenson, E. J.; von Przewoski, B.; Blinov, B. B.; Chu, C. M.; Courant, E. D.; Crandell, D. A.; Kaufman, W. A.; Krisch, A. D.; Nurushev, T. S.; Phelps, R. A.; Ratner, L. G.; Wong, V. K.; Ohmori, C.

    1994-11-01

    We recently studied the spin flipping of a vertically polarized, stored 139-MeV proton beam. To flip the spin, we induced an rf depolarizing resonance by sweeping our rf solenoid magnet's frequency through the resonance frequency. With multiple spin flips, we found a polarization loss of 0.0000+/-0.0005 per spin flip under the best conditions; this loss increased significantly for small changes in the conditions. Minimizing the depolarization during each spin flip is especially important because frequent spin flipping could significantly reduce the systematic errors in stored polarized-beam experiments.

  6. Lightweight Tanks for Storing Liquefied Natural Gas

    Science.gov (United States)

    DeLay, Tom

    2008-01-01

    Single-walled, jacketed aluminum tanks have been conceived for storing liquefied natural gas (LNG) in LNG-fueled motor vehicles. Heretofore, doublewall steel tanks with vacuum between the inner and outer walls have been used for storing LNG. In comparison with the vacuum- insulated steel tanks, the jacketed aluminum tanks weigh less and can be manufactured at lower cost. Costs of using the jacketed aluminum tanks are further reduced in that there is no need for the vacuum pumps heretofore needed to maintain vacuum in the vacuum-insulated tanks.

  7. How the Measurement of Store Choice Behaviour Moderates the Relationship between Distance and Store Choice Behaviour

    DEFF Research Database (Denmark)

    Hansen, Torben; Cumberland, Flemming; Solgaard, Hans Stubbe

    2013-01-01

    The influence of distance on consumer store choice behaviour has been considered in many studies. In that respect, frequency and budget share are frequently used methods of measurement to determine the consumer's store choice behavour. In this study, we propose that the significance of distance i...

  8. Beyond Promotion-Based Store Switching : Antecedents and Consequences of Systematic Multiple-Store Shopping

    NARCIS (Netherlands)

    Gijsbrechts, E.; Campo, K.; Nisol, P.

    2005-01-01

    In this paper, we demonstrate that single-purpose multiple store shopping is not only driven by opportunistic, promotion-based motivations, but may also be part of a longer term shopping planning process based on stable store characteristics.Starting from a utility-maximizing shopping behavior model

  9. Influence of Retail Store Design on the Performance of Retail Store Managers

    Directory of Open Access Journals (Sweden)

    Irina Olimpia SUSANU

    2011-11-01

    Full Text Available The purpose of this study is to examine the influence of retail store design on the performance and job satisfaction of retail store managers. A structural equations model is tested with 200 managers of a large supermarket chain. Moderating effects of crowding and perceived control on design satisfaction are examined. Managerial implications for strategy and theoretical contributions are discussed.

  10. The influence of store image on customer satisfaction: a case study of a shoe store

    Directory of Open Access Journals (Sweden)

    Tarsis Souza Silva

    2010-01-01

    Full Text Available Knowledge of customers' image of a store is an essential factor in the management of retail outlets. This article presents a case study of the effect of the image customers have of a shoe store on their satisfaction, based on a descriptive and quantitative survey, with the application of a structured questionnaire. We then employed factor analysis to obtain seven store image factors: assortment, convenience, reputation, price, atmosphere, layout and service. The results show that the factor that most affects customer satisfaction in the store studied is service, and that atmosphere and layout have no effect in this respect. The results provide a better understanding of the role store image plays in customer satisfaction and loyalty.

  11. TO ALL USERS OF GAS FROM STORES

    CERN Multimedia

    SPL Division

    2002-01-01

    Users of gas from stores are requested to return empty gas containers (cylinders, etc.) as soon as possible after use. These containers belong to the supplier and are therefore subject to a hire charge. Gas users are invited to place the empty containers at the official delivery points, where they will be collected by the supplier. Thank you. SPL Division Logistics Group

  12. The Changing Face of the College Store

    Science.gov (United States)

    Halligan, Tom

    2008-01-01

    Increased competition from Internet merchants, coupled with the swelling popularity of electronic books and skyrocketing textbook prices, is forcing the nation's college stores to get creative, find new ways to boost revenues, and drive sales of books and other merchandise to students and faculty. To make up for lost revenue as a result of…

  13. Depolarization of UCN stored in material traps

    CERN Document Server

    Serebrov, A; Lasakov, M; Rudnev, Y; Krasnoschekova, I A; Geltenbort, P; Butterworth, J; Bowles, T; Morris, C; Seestrom, S; Smith, D; Young, A R

    2000-01-01

    Depolarization of ultra-cold neutrons (UCN) stored in material traps was first observed. The probability of UCN spin flip per reflection depends on the trap material and varies from 7x10 sup - sup 6 (beryllium) to 10 sup - sup 4 (glass).

  14. Fuels and Lubricants. Selecting and Storing.

    Science.gov (United States)

    Parady, W. Harold; Colvin, Thomas S.

    The manual presents basic information for the person who plans to operate or service tractors, trucks, industrial engines, and automobiles. It tells how to select the proper fuels and lubricants and how to store them properly. Although there are no prerequisites to the study of the text, a general knowledge of engines and mobile-type vehicles is…

  15. PERSONALITY INFLUENCES ON ONLINE STORES CUSTOMERS BEHAVIOR

    Directory of Open Access Journals (Sweden)

    Costinel DOBRE

    2015-02-01

    Full Text Available Online customer behaviors include a wide range of processes and activities related to sensory reactions, perceptions, attitude formation, preferences, decisions, satisfaction evaluation, and loyalty formation. Online customer behaviors are influenced by exogenous and endogenous factors. Exogenous factors include attributes associated with the online retailer and the consumer’s environmental influences. Endogenous factors include characteristics attributed to consumers. Of these, personality has major influences on customer behavior in the online stores. In this paper we highlight the influences of personality on important decision making variables linked to the customer’s online visiting, buying and post purchase process. Thus, we intend to point out the influences of personality on the criteria used in evaluating stores, on expectations customers form towards stores, on the perception of store performance and the assessment of satisfaction. This will involve carrying out a survey, and its administration will be performed on the Internet. The sample under research will comprise respondents who own an account on the social network Facebook, assuming these respondents have time and are more likely to have purchased online at least once. The results of this study are useful both for academic researchers and practitioners engaged in online marketing, online communication and web design.

  16. 19 CFR 122.47 - Stores list.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Stores list. 122.47 Section 122.47 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for...

  17. The Strategic Management of Store Brand Perceived Quality

    Science.gov (United States)

    Yang, Defeng

    Store brand plays a vital role in the success of retailers. Perceived quality is one of important factors influencing consumers' store brand purchase intention. Store brand perceived quality is lower compared with objective quality or national brand. For this end, the purpose of this article is to examine how to manage store brand perceived quality in strategic level. This article firstly discusses how consumers evaluate product quality, and the theoretical background of the reason that store brand perceived quality is lower from the view of cue related theories. Then, consumers' store brand quality evaluation is explored. Finally, this article presents several strategic tactics to increase store brand perceived quality. These tactics include choosing store's name as store brand name, making large advertising investment, improving store brand product package, and strengthening the relationship with store brand product suppliers.

  18. Evaluating the use of in-store measures in retail food stores and restaurants in Brazil

    Directory of Open Access Journals (Sweden)

    Ana Clara Duran

    2015-01-01

    Full Text Available ABSTRACTOBJECTIVE To assess inter-rater reliability, test-retest reliability, and construct validity of retail food store, open-air food market, and restaurant observation tools adapted to the Brazilian urban context.METHODS This study is part of a cross-sectional observation survey conducted in 13 districts across the city of Sao Paulo, Brazil in 2010-2011. Food store and restaurant observational tools were developed based on previously available tools, and then tested it. They included measures on the availability, variety, quality, pricing, and promotion of fruits and vegetables and ultra-processed foods. We used Kappa statistics and intra-class correlation coefficients to assess inter-rater and test-retest reliabilities in samples of 142 restaurants, 97 retail food stores (including open-air food markets, and of 62 restaurants and 45 retail food stores (including open-air food markets, respectively. Construct validity as the tool’s abilities to discriminate based on store types and different income contexts were assessed in the entire sample: 305 retail food stores, 8 fruits and vegetable markets, and 472 restaurants.RESULTS Inter-rater and test-retest reliability were generally high, with most Kappa values greater than 0.70 (range 0.49-1.00. Both tools discriminated between store types and neighborhoods with different median income. Fruits and vegetables were more likely to be found in middle to higher-income neighborhoods, while soda, fruit-flavored drink mixes, cookies, and chips were cheaper and more likely to be found in lower-income neighborhoods.CONCLUSIONS The measures were reliable and able to reveal significant differences across store types and different contexts. Although some items may require revision, results suggest that the tools may be used to reliably measure the food stores and restaurant food environment in urban settings of middle-income countries. Such studies can help .inform health promotion interventions and

  19. Analyse mobiler Applikationen zu HNO spezifischen Suchbegriffen im Google Play Store und iTunes Store.

    OpenAIRE

    Dakara, C; Hansen, S.; Wagenmann, M; Schipper, J; Werminghaus, P

    2015-01-01

    Einleitung: Mit zunehmender Verfügbarkeit von mobilen Applikationen für Smartphones eröffnen sich neue Wege zur Verbreitung medizinischer Inhalte. Daher untersuchten wir die gängigen App-Stores nach HNO-relevanten Begriffen um die mobilen Applikationen (mA) zu analysieren. Methoden: Im November 2014 wurden "Google Play Store" (GPS) und "iTunes Store" (iTS) auf HNO-relevante Suchbegriffe auf Deutsch durchsucht. Die mA wurden kategorisiert nach Thema, Bewertung, Anzahl der Bewertungen, Prei...

  20. Salmonella Dublin kan give store tab

    DEFF Research Database (Denmark)

    Nielsen, Torben Dahl; Nielsen, Liza Rosenbaum; Kudahl, Anne Margrethe Braad

    2012-01-01

    Store besætninger lider størst økonomisk tab ved infektion med Salmonella Dublin. Selv i en veldrevet besætning kan tabet løbe op i mellem 1,3 og 3,3 millioner kr. over en tiårs periode. Ved uhensigtsmæssige hygiejne- og managementrutiner kan tabet nemt blive meget højere.......Store besætninger lider størst økonomisk tab ved infektion med Salmonella Dublin. Selv i en veldrevet besætning kan tabet løbe op i mellem 1,3 og 3,3 millioner kr. over en tiårs periode. Ved uhensigtsmæssige hygiejne- og managementrutiner kan tabet nemt blive meget højere....

  1. Gaining Customers` Trust In Online Stores

    OpenAIRE

    Anamaria Severin-Humelnicu

    2010-01-01

    Trust is very important in running businesses on the Internet. It plays a significant role in the actions a consumer undertakes in the online purchase process. An online store will never reach the desired level of sales until it gains the trust of its consumers. Building confidence is the key of succes in electronic commerce. Therefore, any online retailer should strive to achieve this goal

  2. Schedulers with load-store queue awareness

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Tong; Eichenberger, Alexandre E.; Jacob, Arpith C.; Sura, Zehra N.

    2017-01-24

    In one embodiment, a computer-implemented method includes tracking a size of a load-store queue (LSQ) during compile time of a program. The size of the LSQ is time-varying and indicates how many memory access instructions of the program are on the LSQ. The method further includes scheduling, by a computer processor, a plurality of memory access instructions of the program based on the size of the LSQ.

  3. Schedulers with load-store queue awareness

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Tong; Eichenberger, Alexandre E.; Jacob, Arpith C.; Sura, Zehra N.

    2017-02-07

    In one embodiment, a computer-implemented method includes tracking a size of a load-store queue (LSQ) during compile time of a program. The size of the LSQ is time-varying and indicates how many memory access instructions of the program are on the LSQ. The method further includes scheduling, by a computer processor, a plurality of memory access instructions of the program based on the size of the LSQ.

  4. Protecting Stored Data on Android Devices

    Directory of Open Access Journals (Sweden)

    Raluca Alina Cojocaru

    2014-03-01

    Full Text Available According to the latest statistics, the Android has become the world’s most popular operating system used for smartphones. Not only its popularity continues to increase, but also the number of malicious hackers who want to compromise mobile applications for their own gain. This paper reviews the protections offered by the Android Platform for storing application data, and provides means to enforce them.

  5. Perturbed Motion of Airplane and Safe Store Separation

    Directory of Open Access Journals (Sweden)

    S. C. Raisinghani

    1984-07-01

    Full Text Available A method is presented to predict the perturbed motion of an airplane following stores jettisoning. The mass, moment of inertia, forces, and moments acting on the airplane are suitable split into contributions from the stores and the rest of the airplane parts. The seperation of stores is assumed to result in a step change of mass, moment of intertai, forces, and moments contributed by stores. The resulting set of perturbed state equations of motion are solved for two illustrative airplane stroes combination. A criterion is evolved to qualitatively indicate locations for safe store separation. It is suggested that the present method be used to predict airplane perturbed motion following stores separation for a given airplane store combination and results be used in conjunction with store trajectory analysis for finally declaring a store location as safe unsafe.

  6. Storing wind energy into electrical accumulators

    Science.gov (United States)

    Dordescu, M.; Petrescu, D. I.; Erdodi, G. M.

    2016-12-01

    Shall be determined, in this work, the energy stored in the accumulators electrical, AE, at a wind system operating at wind speeds time-varying. mechanical energy caught in the turbine from the wind, (TV), is transformed into electrical energy by the generator synchronous with the permanent magnets, GSMP. The Generator synchronous with the permanent magnets saws, via a rectifier, energy in a battery AE, finished in a choice of two: variant 1-unregulated rectifier and variant of the 2-controlled rectifier and task adapted. Through simulation determine the differences between the two versions

  7. Project StORe: Social Science report

    OpenAIRE

    Burton, Guy

    2006-01-01

    There was widespread support across the social science research community regarding the aims of the StORe Project Nearly half of social science respondents claimed that both source-to-output and out-put-to source repositories would offer a ‘significant advantage to my work’; a third in both cases claimed it would be ‘useful but not of major significance’ Postgraduate students were generally more enthusiastic about source-to-output and output-to-source repositories than acade...

  8. Stochastic Optimal Control Models for Online Stores

    CERN Document Server

    Bradonjić, Milan

    2011-01-01

    We present a model for the optimal design of an online auction/store by a seller. The framework we use is a stochastic optimal control problem. In our setting, the seller wishes to maximize her average wealth level, where she can control her price per unit via her reputation level. The corresponding Hamilton-Jacobi-Bellmann equation is analyzed for an introductory case. We then turn to an empirically justified model, and present introductory analysis. In both cases, {\\em pulsing} advertising strategies are recovered for resource allocation. Further numerical and functional analysis will appear shortly.

  9. Business Plan: Video Game Rental Store

    OpenAIRE

    Kemppi, Tuomas

    2013-01-01

    The purpose of this report is to create a business plan for a video game rental store. It includes research on similar companies in other countries, and it determines if the concept would work in Finland. In addition to this, the report also includes research on what steps need to be taken in order to start and run a video game rental business in Finland. The report also goes over the current trends in the video game industry, and takes a look at where the industry is heading. Based...

  10. RFID Makes Common People an Uncommon Store

    Institute of Scientific and Technical Information of China (English)

    Mark; Roberti

    2010-01-01

    The Mexican retailer is using RFID to enhance the customer experience,and to provide supplierswith better inventory data. Dec.13,2010-Common People,an independent conceptstore that opened last month in Mexico City,is employing radiofrequency identification technology to enhance an already uncom-mon customer experience,as well as improve the management ofinventory."When we came up with the idea for a concept store,we knewwe wanted to bring in not just the most interesting products,but

  11. Atomic physics experiments with cooled stored ions

    Science.gov (United States)

    Schuch, Reinhold

    2004-10-01

    This presentation contains examples of recent atomic physics experiments with stored and cooled ion beams from the CRYRING facility in Stockholm. One of these experiments uses the high luminosity of a cooled MeV proton beam in a He COLTRIMS apparatus (COLd supersonic He gas-jet Target for Recoil Ion Momentum Spectroscopy) for measuring correlation effects in transfer ionization. Another class of experiments exploits the cold electron beam available in the CRYRING electron cooler and cooled heavy-ion beams for recombination experiments. A section concerns the still rather open question of the puzzling recombination enhancement over the radiative recombination theory. Dielectronic resonances at meV-eV energy are measured with a resolution in the order of 10-3-10-2 eV with highly charged ions stored at several hundreds of MeV kinetic energy in the ring. These resonances provide a serious challenge to theories for describing correlation, relativistic, QED effects, and isotope shifts in highly ionized ions. Applications of recombination rates with complex highly charged ions for fusion and astrophysical plasmas are shown.

  12. Atomic physics experiments with cooled stored ions

    Energy Technology Data Exchange (ETDEWEB)

    Schuch, Reinhold E-mail: schuch@physto.se

    2004-10-11

    This presentation contains examples of recent atomic physics experiments with stored and cooled ion beams from the CRYRING facility in Stockholm. One of these experiments uses the high luminosity of a cooled MeV proton beam in a He COLTRIMS apparatus (COLd supersonic He gas-jet Target for Recoil Ion Momentum Spectroscopy) for measuring correlation effects in transfer ionization. Another class of experiments exploits the cold electron beam available in the CRYRING electron cooler and cooled heavy-ion beams for recombination experiments. A section concerns the still rather open question of the puzzling recombination enhancement over the radiative recombination theory. Dielectronic resonances at meV-eV energy are measured with a resolution in the order of 10{sup -3}-10{sup -2} eV with highly charged ions stored at several hundreds of MeV kinetic energy in the ring. These resonances provide a serious challenge to theories for describing correlation, relativistic, QED effects, and isotope shifts in highly ionized ions. Applications of recombination rates with complex highly charged ions for fusion and astrophysical plasmas are shown.

  13. Modern Stored-Product Insect Pest Management

    Directory of Open Access Journals (Sweden)

    Hagstrum David William

    2014-07-01

    Full Text Available Stored-product entomologists have a variety of new monitoring, decision-making, biological, chemical, and physical pest management tools available to them. Two types of stored-product insect populations are of interest: insects of immediate economic importance infesting commodities, and insects that live in food residues in equipment and facilities. The sampling and control methods change as grain and grain products move from field to consumer. There are also some changes in the major insect pest species to take into consideration. In this review, we list the primary insect pests at each point of the marketing system, and indicate which sampling methods and control strategies are most appropriate. Economic thresholds for insect infestation levels developed for raw commodity storage, processing plants, and retail business allow sampling-based pest management to be done before insect infestations cause economic injury. Taking enough samples to have a representative sample (20-30 samples will generally provide enough information to classify a population as above or below an economic threshold.

  14. Bioprocessing of a stored mixed liquid waste

    Energy Technology Data Exchange (ETDEWEB)

    Wolfram, J.H.; Rogers, R.D. [Idaho National Engineering Lab., Idaho Falls, ID (United States); Finney, R. [Mound Applied Technologies, Miamisburg, OH (United States)] [and others

    1995-12-31

    This paper describes the development and results of a demonstration for a continuous bioprocess for mixed waste treatment. A key element of the process is an unique microbial strain which tolerates high levels of aromatic solvents and surfactants. This microorganism is the biocatalysis of the continuous flow system designed for the processing of stored liquid scintillation wastes. During the past year a process demonstration has been conducted on commercial formulation of liquid scintillation cocktails (LSC). Based on data obtained from this demonstration, the Ohio EPA granted the Mound Applied Technologies Lab a treatability permit allowing the limited processing of actual mixed waste. Since August 1994, the system has been successfully processing stored, {open_quotes}hot{close_quotes} LSC waste. The initial LSC waste fed into the system contained 11% pseudocumene and detectable quantities of plutonium. Another treated waste stream contained pseudocumene and tritium. Data from this initial work shows that the hazardous organic solvent, and pseudocumene have been removed due to processing, leaving the aqueous low level radioactive waste. Results to date have shown that living cells are not affected by the dissolved plutonium and that 95% of the plutonium was sorbed to the biomass. This paper discusses the bioprocess, rates of processing, effluent, and the implications of bioprocessing for mixed waste management.

  15. Mycotoxigenic molds in spices from Macedonian stores

    Directory of Open Access Journals (Sweden)

    Kungulovski Džoko

    2011-01-01

    Full Text Available Twenty-six samples of spices most frequently occurring in the stores of the Republic of Macedonia were examined for their fungal contamination and the incidence of Aspergillus and Penicillium species and their teleomorphs. It included mainly commercial packages most frequently occurring in the stores of the Republic of Macedonia. According to the relative frequency of each of the isolated species, the typical mycoflora of these samples includes A. niger, A. flavus, A. fumigatus, P. chrysogenum and Eurotium sp. Fungal counts varied from log10 < 2 CFU g-1 (DG18 at 25oC; DRBC at 25oC, for a sample of paprika, to log10 6.17 CFU g-1 (DG18 at 25oC, for a sample of bay leaf. During the experiment, A. flavus was detected in 17 samples, out of which 7 isolates were capable of producing Af-B1, and 4 isolates produced Af-B2. All isolates of A. nomius and A. parasiticus, in the experimental conditions, produced Af-B1, Af-B2, Af-G1 and Af-G2.

  16. Silent store detection and recording in memory storage

    Energy Technology Data Exchange (ETDEWEB)

    Bose, Pradip; Cher, Chen-Yong; Nair, Ravi

    2017-03-07

    An aspect includes receiving a write request that includes a memory address and write data. Stored data is read from a memory location at the memory address. Based on determining that the memory location was not previously modified, the stored data is compared to the write data. Based on the stored data matching the write data, the write request is completed without writing the write data to the memory and a corresponding silent store bit, in a silent store bitmap is set. Based on the stored data not matching the write data, the write data is written to the memory location, the silent store bit is reset and a corresponding modified bit is set. At least one of an application and an operating system is provided access to the silent store bitmap.

  17. Silent store detection and recording in memory storage

    Energy Technology Data Exchange (ETDEWEB)

    Bose, Pradip; Cher, Chen-Yong; Nair, Ravi

    2017-03-14

    An aspect includes receiving a write request that includes a memory address and write data. Stored data is read from a memory location at the memory address. Based on determining that the memory location was not previously modified, the stored data is compared to the write data. Based on the stored data matching the write data, the write request is completed without writing the write data to the memory and a corresponding silent store bit, in a silent store bitmap is set. Based on the stored data not matching the write data, the write data is written to the memory location, the silent store bit is reset and a corresponding modified bit is set. At least one of an application and an operating system is provided access to the silent store bitmap.

  18. Silent store detection and recording in memory storage

    Science.gov (United States)

    Bose, Pradip; Cher, Chen-Yong; Nair, Ravi

    2016-09-20

    An aspect includes receiving a write request that includes a memory address and write data. Stored data is read from a memory location at the memory address. Based on determining that the memory location was not previously modified, the stored data is compared to the write data. Based on the stored data matching the write data, the write request is completed without writing the write data to the memory and a corresponding silent store bit, in a silent store bitmap is set. Based on the stored data not matching the write data, the write data is written to the memory location, the silent store bit is reset and a corresponding modified bit is set. At least one of an application and an operating system is provided access to the silent store bitmap.

  19. In-Store Experimental Approach to Pricing and Consumer Behavior

    Science.gov (United States)

    Sigurdsson, Valdimar; Foxall, Gordon; Saevarsson, Hugi

    2010-01-01

    This study assessed how, and to what extent, it is possible to use behavioral experimentation and relative sales analysis to study the effects of price on consumers' brand choices in the store environment. An in-store experiment was performed in four stores to investigate the effects of different prices of a target brand on consumers' relative…

  20. nuSTORM: Neutrinos from STORed Muons

    CERN Document Server

    Kyberd, P; Coney, L; Pascoli, S; Ankenbrandt, C; Brice, S J; Bross, A D; Cease, H; Kopp, J; Mokhov, N; Morfin, J; Neuffer, D; Popovic, M; Rubinov, P; Striganov, S; Blondel, A; Bravar, A; Noah, E; Bayes, R; Soler, F J P; Dobbs, A; Long, K; Pasternak, J; Santos, E; Wascko, M O; Agarwalla, S K; Bogacz, S A; Mori, Y; Lagrange, J B; de Gouvêa, A; Kuno, Y; Sato, A; Blackmore, V; Cobb, J; Tunnell, C D; Link, J M; Huber, P; Winter, W

    2012-01-01

    The results of LSND and MiniBooNE, along with the recent papers on a possible reactor neutrino flux anomaly give tantalizing hints of new physics. Models beyond the neutrino-SM have been developed to explain these results and involve one or more additional neutrinos that are non-interacting or "sterile." Neutrino beams produced from the decay of muons in a racetrack-like decay ring provide a powerful way to study this potential new physics. In this Letter of Intent, we describe a facility, nuSTORM, "Neutrinos from STORed Muons," and an appropriate far detector for neutrino oscillation searches at short baseline. We present sensitivity plots that indicated that this experimental approach can provide over 10 sigma confirmation or rejection of the LSND/MinBooNE results. In addition we indicate how the facility can be used to make precision neutrino interaction cross section measurements important to the next generation of long-baseline neutrino oscillation experiments.

  1. Store-operated calcium signaling in neutrophils.

    Science.gov (United States)

    Clemens, Regina A; Lowell, Clifford A

    2015-10-01

    Calcium signals in neutrophils are initiated by a variety of cell-surface receptors, including formyl peptide and other GPCRs, FcRs, and integrins. The predominant pathway by which calcium enters immune cells is termed SOCE, whereby plasma membrane CRAC channels allow influx of extracellular calcium into the cytoplasm when intracellular ER stores are depleted. The identification of 2 key families of SOCE regulators, STIM calcium "sensors" and ORAI calcium channels, has allowed for genetic manipulation of SOCE pathways and provided valuable insight into the molecular mechanism of calcium signaling in immune cells, including neutrophils. This review focuses on our current knowledge of the molecules involved in neutrophil SOCE and how study of these molecules has further informed our understanding of the role of calcium signaling in neutrophil activation.

  2. Chain store management through private labels strategy

    Directory of Open Access Journals (Sweden)

    Martina Sopta

    2007-07-01

    Full Text Available The purpose of this paper is to examine the market shares of private labels in the European Union and on the global market, and to compare the results of the analysis with the level of presence of private labels on the Croatian market. Moreover, through the application of macro and microeconomic tools, the author tried to estimate the future trends of private labels in Croatia.For the purpose of the paper secondary and primary data was used in the research. Relevant scientific and professional literature of local and foreign authors was analyzed. In addition, a few recent research studies were analyzed and their results compared. Field research has been conducted by the survey method, with 225 respondents included in the intentional sample.The main hypothesis of the paper based on research is that, in total sales, private labels are gaining a growing share in all markets, regardless of the development level of those markets. Alongside the main hypothesis of the work, three supporting hypotheses were tested to see which private labels are a good alternative to other brands on the world market. Private labels are generally developed on generic products. The third supporting hypothesis starts from the assumption that the investments in the promotion of private labels are negligible, resulting in lower prices of thoseproducts. The results of research and analyses in the work indicate that the position of private labels will strengthen internationally, as part of the process of liberalization and globalization of trade flows. In the process of purchase of private labels the positioning of the point of sale and price have an increasing contribution. With the concentration of commerce in chain stores, the share of private labels grows, approaching a half of the total sales in some countries. Considering the Croatian market, according to the international product life cycle theory, the share of private labels in the total sales will grow in the future

  3. Design variables and constraints in fashion store design processes

    DEFF Research Database (Denmark)

    Haug, Anders; Borch Münster, Mia

    2015-01-01

    Purpose: – Several frameworks of retail store environment variables exist, but as shown by this paper, they are not particularly well-suited for supporting fashion store design processes. Thus, in order to provide an improved understanding of fashion store design, the purpose of this paper...... is to identify the most important store design variables, organise these variables into categories, understand the design constraints between categories, and determine the most influential stakeholders. Design/methodology/approach: – Based on a discussion of existing literature, the paper defines a framework...... of store design ariables and constraints between these. The framework is investigated through six case studies of fashion store design projects. Findings: – Through a discussion of literature and empirical studies, the paper: identifies the most important store design variables, organises these variables...

  4. Storing Renewable Energy in the Hydrogen Cycle.

    Science.gov (United States)

    Züttel, Andreas; Callini, Elsa; Kato, Shunsuke; Atakli, Züleyha Özlem Kocabas

    2015-01-01

    An energy economy based on renewable energy requires massive energy storage, approx. half of the annual energy consumption. Therefore, the production of a synthetic energy carrier, e.g. hydrogen, is necessary. The hydrogen cycle, i.e. production of hydrogen from water by renewable energy, storage and use of hydrogen in fuel cells, combustion engines or turbines is a closed cycle. Electrolysis splits water into hydrogen and oxygen and represents a mature technology in the power range up to 100 kW. However, the major technological challenge is to build electrolyzers in the power range of several MW producing high purity hydrogen with a high efficiency. After the production of hydrogen, large scale and safe hydrogen storage is required. Hydrogen is stored either as a molecule or as an atom in the case of hydrides. The maximum volumetric hydrogen density of a molecular hydrogen storage is limited to the density of liquid hydrogen. In a complex hydride the hydrogen density is limited to 20 mass% and 150 kg/m(3) which corresponds to twice the density of liquid hydrogen. Current research focuses on the investigation of new storage materials based on combinations of complex hydrides with amides and the understanding of the hydrogen sorption mechanism in order to better control the reaction for the hydrogen storage applications.

  5. Influence of Oxidative Stress on Stored Platelets

    Directory of Open Access Journals (Sweden)

    K. Manasa

    2016-01-01

    Full Text Available Platelet storage and its availability for transfusion are limited to 5-6 days. Oxidative stress (OS is one of the causes for reduced efficacy and shelf-life of platelets. The studies on platelet storage have focused on improving the storage conditions by altering platelet storage solutions, temperature, and materials. Nevertheless, the role of OS on platelet survival during storage is still unclear. Hence, this study was conducted to investigate the influence of storage on platelets. Platelets were stored for 12 days at 22°C. OS markers such as aggregation, superoxides, reactive oxygen species, glucose, pH, lipid peroxidation, protein oxidation, and antioxidant enzymes were assessed. OS increased during storage as indicated by increments in aggregation, superoxides, pH, conjugate dienes, and superoxide dismutase and decrements in glucose and catalase. Thus, platelets could endure OS till 6 days during storage, due to the antioxidant defense system. An evident increase in OS was observed from day 8 of storage, which can diminish the platelet efficacy. The present study provides an insight into the gradual changes occurring during platelet storage. This lays the foundation towards new possibilities of employing various antioxidants as additives in storage solutions.

  6. Storing Quantum Information via Atomic Dark Resonances

    CERN Document Server

    Caruso, Filippo

    2010-01-01

    In this thesis, after a brief review of some concepts of Quantum Optics, we analyze a three-level atomic system in the conditions of electromagnetically induced transparency (EIT), and we investigate the propagation of a gaussian pulse along a cigar-shaped cloud of both cold and hot atoms in EIT regime. In particular, we show that it is possible to amplify a slow propagating pulse without population inversion. We also analyze the regime of anomalous light propagation showing that it is possible to observe superluminal energy propagation. In these conditions, it is possible to imprint reversibly ('write') the information carried by the photons onto the atoms, specifically as a coherent pattern of atomic spins, and later the information stored in the atomic spins can be transferred back ('read') to the light field, implementing in this way a quantum memory. Besides, we analyze the propagation of a quantum field in an EIT medium sustaining dark state polaritons (DSP) in a quasi-particle picture. Here, the decohe...

  7. Building a Distributed Infrastructure for Scalable Triple Stores

    Institute of Scientific and Technical Information of China (English)

    Jing Zhou; Wendy Hall; David De Roure

    2009-01-01

    Built specifically for the Semantic Web, triple stores are required to accommodate a large number of RDF triples and remain primarily centralized. As triple stores grow and evolve with time, there is a demanding need for scalable techniques to remove resource and performance bottlenecks in such systems. To this end, we propose a fully decentralized peer-to-peer architecture for large scale triple stores in which triples are maintained by individual stakeholders, and a semantics-directed search protocol, mediated by topology reorganization, for locating triples of interest. We test our design through simulations and the results show anticipated improvements over existing techniques for distributed triple stores. In addition to engineering future large scale triple stores, our work will in particular benefit the federation of stand-alone triple stores of today to achieve desired scalability.

  8. Remote pivot decoupler pylon: Wing/store flutter suppressor

    Science.gov (United States)

    Hassler, J. M., Jr. (Inventor)

    1986-01-01

    A device for suspending a store from an aerodynamic support surface, such an an aircraft wing, and more specifically, for improving upon singlet pivot decoupler pylons by reducing both frequency of active store, alignment, and alignment system space and power requirements. Two links suspend a lower pylon/rack section and releasable attached store from an upper pylon section mounted under the wing. The links allow the lower pylon section to rotate in pitch about a remote pivot point. A leaf spring connected between the lower section and electrical alignment system servomechanism provides pitch alignment of the lower section/store combination. The servomechanism utilizes an electric servomotor to drive the gear train and reversibly move the leaf spring, thereby maintaining the pitch attitude of the store within acceptable limits. The damper strokes when the lower section rotates to damp large oscillations of store.

  9. Virtual and game-inspired approaches to concept store planning

    DEFF Research Database (Denmark)

    Andreasen, Kristian Emil; Tambo, Torben

    2012-01-01

    Concept store development needs to be consistent with brand design guidelines, but also adapted to appeal to local conditions, building premises, and demographical preconditions. Visual appearance and consumer experience are assumed to be the fundamental factors. Store development processes...... will typically involve engagement from franchisers, landlord, chain management, visual merchandisers, architects and construction specialists. In this paper a system is presented and discussed for electronic modeling of concept store. The system is based on principles of computer games, gamification, to let...... for global manufacturers and brand owners who wants to roll out concept stores globally as individual stores in malls, high street or theme parks, or as shop-in-shops in department stores. Key theory applies to gamification emphasizing on personal reward systems, experience of achievement, sense...

  10. Performances of modern domestic hot-water stores

    Energy Technology Data Exchange (ETDEWEB)

    Spur, Roman [Czech Technical University in Prague (Czech Republic). Department of Environmental and Building Services, Faculty of Civil Engineering; Fiala, Dusan [Institute of Energy and Sustainable Development, De Montfort University, Leicester (United Kingdom); Nevrala, Dusan [Enplan - heating technology company, Prague (Czech Republic); Probert, Doug [Cranfield University, Bedford (United Kingdom). School of Engineering

    2006-08-15

    Several designs of domestic hot-water (DHW) store, including those with immersed heat-exchangers (HXs), are commercially available. So there is a need for a method that accurately assesses their effectivenesses. In this study, the behaviours of a novel stratified, and two standard, stores were analyzed. The TRNSYS simulation software was enhanced to simulate the functioning of those stores. The resulting mathematical model was validated using measurements obtained from experiments, which required a realistic daily DHW draw-off for testing the DHW systems. Evaluation of a user-related effectivenesses (URE) for each of the three tanks tested showed that the inner configurations of: (i) the tank and (ii) the immersed HX can significantly affect the store's performance. The stratified store was up to 32% more effective than the commonly employed commercially-available store. (author)

  11. ADOPTION OF ECR PRACTICES IN MINNESOTA GROCERY STORES

    OpenAIRE

    Paul F. PHUMPIU; King, Robert P.

    1997-01-01

    Efficient Consumer Response (ECR) is an industry-wide, collaborative initiative to re-engineer the grocery supply chain. This report presents findings from a study of ECR adoption in Minnesota grocery stores. Data were collected through interviews with managers of forty stores that are broadly distributed over store sizes, locations, and organizational forms. The interviews focused on business practices and technologies related to inventory management and ordering, shelf-space allocation and ...

  12. FINNISH ONLINE STORE TO RUSSIA – CASE COMPANY X

    OpenAIRE

    Hirvonen, Susanna

    2015-01-01

    The purpose of this research is to provide a framework in the context of online store usability for the case company X and other Finnish online store companies. If they decide to operate in the Russian online market, they may have a better chance to succeed due to this framework. This study is strictly focused on online store usability. The study reveals whether usability can be defined as the key issue in gaining the trust of Russian online consumers. Qualitative research methods w...

  13. Improving Seek Time for Column Store Using MMH Algorithm

    CERN Document Server

    Apte, Tejaswini; Goyal, Dr A K

    2012-01-01

    Hash based search has, proven excellence on large data warehouses stored in column store. Data distribution has significant impact on hash based search. To reduce impact of data distribution, we have proposed Memory Managed Hash (MMH) algorithm that uses shift XOR group for Queries and Transactions in column store. Our experiments show that MMH improves read and write throughput by 22% for TPC-H distribution.

  14. The influence of boutique store atmosphere on customer satisfaction, store loyalty and repurchase intention / Bianca van Niekerk

    OpenAIRE

    Van Niekerk, Bianca

    2015-01-01

    The global fashion retail industry has been characterised by fierce competition for numerous years. Boutiques face increasing pressure to distinctly differentiate themselves from competing retail stores offering fashion merchandise, since customers are becoming ever more demanding as fashion evolves and new trends reach South African retail stores. Accordingly, marketers have to ensure customer satisfaction, build store loyalty, and stimulate repurchase intentions in the fashion retail indust...

  15. 76 FR 19741 - Exemption for Retail Store Operations

    Science.gov (United States)

    2011-04-08

    ..., poultry and poultry products that a retail store can sell to hotels, restaurants, and similar institutions... poultry products. Sales to Hotels, Restaurants, and Similar Institutions Under these regulations, sales to hotels, restaurants, and similar institutions (other than household consumers) disqualify a store...

  16. Power Law of Customers’ Expenditures in Convenience Stores

    Science.gov (United States)

    Mizuno, Takayuki

    2008-03-01

    In a convenience store chain, a tail of the cumulative density function of the expenditure of a person during a single shopping trip follows a power law with an exponent of -2.5. The exponent is independent of the location of the store, the shopper's age, the day of week, and the time of day.

  17. 14 CFR 1214.605 - Preflight packing and storing.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Preflight packing and storing. 1214.605 Section 1214.605 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Mementos Aboard Space Shuttle Flights § 1214.605 Preflight packing and storing. (a) Items intended for...

  18. 46 CFR 188.10-7 - Chemical stores.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Chemical stores. 188.10-7 Section 188.10-7 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-7 Chemical stores. This term means those chemicals intended for use in the performance of the vessel's scientific activities and is further...

  19. Learning Experiences for Mentally Handicapped Students in a School Store.

    Science.gov (United States)

    David, Carol

    A supermarket chain supplies a small grocery store in an elementary school in Jefferson County, Kentucky. The store program seeks to provide learning experiences for students, as they make selections, spend their earnings, and save for later purchases. Students with multiple handicaps and students with severe/profound handicaps shop in the store…

  20. Using a virtual grocery store to simulate shopping behaviour

    NARCIS (Netherlands)

    Herpen, van H.W.I.; Yu, T.; Broek, van den E.M.F.; Trijp, van J.C.M.

    2014-01-01

    Introduction Simulating a store environment by using virtual reality techniques offers important potential advantages for research into consumer behaviour. Through the use of virtual reality, the store can be simulated in a realistic and cost-efficient way [1,9]. This allows researchers to collect d

  1. First come, First served: Enhancing the Convenience Store Service Experience

    Directory of Open Access Journals (Sweden)

    Yuan-Ling Chiao

    2012-09-01

    Full Text Available One distinctive characteristic of Taiwanese city streets is the omnipresence of convenience stores. These clean, brightly lit stores are in operation 24 hours a day, seven days a week, and offer a wide range of constantly updated lifestyle products and services. Past research in convenience stores have often overlooked the work experiences of convenience store employees, and their contribution to the overall service experience. Thus, the goal of this exploratory study is to explore the convenience store work environment, and to provide some suggestions for in-store technological enhancements. Data was collected through in-depth interviewing, field study observations and Living Lab methodologies. Our research reveals that convenience store employees experience several types of physical, mental and emotional strains throughout their shifts. These strains are often derived from excessive physical exertion and unpleasant interactions with customers. We suggest that certain in-store technological enhancements, such as seamless sensing and seamful actuating, can serve to alleviate employee sense of pressure and anxiety during customer interactions.

  2. Mobile app and app store analysis, testing and optimisation

    OpenAIRE

    Harman, M.; Al-Subaihin, A.; Jia, Y.; Martin, W.; Sarro, F.; Zhang, Y.

    2016-01-01

    This talk presents results on analysis and testing of mobile apps and app stores, reviewing the work of the UCL App Analysis Group (UCLappA) on App Store Mining and Analysis. The talk also covers the work of the UCL CREST centre on Genetic Improvement, applicable to app improvement and optimisation.

  3. 25 CFR 226.38 - Measuring and storing oil.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Measuring and storing oil. 226.38 Section 226.38 Indians... LANDS FOR OIL AND GAS MINING Requirements of Lessees § 226.38 Measuring and storing oil. All production.... Facilities suitable for containing and measuring accurately all crude oil produced from the wells shall...

  4. Self-organizing strategies for a column-store database

    NARCIS (Netherlands)

    Ivanova, M.G.; Kersten, M.L.; Nes, N.J.

    2008-01-01

    Column-store database systems open new vistas for improved maintenance through self-organization. Individual columns are the focal point, which simplify balancing conflicting requirements. This work presents two workload-driven self-organizing techniques in a column-store, i.e. adaptive segmentation

  5. 41 CFR 109-1.5108-3 - Stores inventories.

    Science.gov (United States)

    2010-07-01

    ... Regulations System (Continued) DEPARTMENT OF ENERGY PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.51-Personal Property Management Standards and Practices § 109-1.5108-3 Stores inventories. Perpetual... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Stores inventories....

  6. Volatile organic compounds in fourteen U.S. retail stores.

    Science.gov (United States)

    Nirlo, E L; Crain, N; Corsi, R L; Siegel, J A

    2014-10-01

    Retail buildings have a potential for both short-term (customer) and long-term (occupational) exposure to indoor pollutants. However, little is known about volatile organic compound (VOC) concentrations in the retail sector and influencing factors, such as ventilation, in-store activities, and store type. We measured VOC concentrations and ventilation rates in 14 retail stores in Texas and Pennsylvania. With the exception of formaldehyde and acetaldehyde, VOCs were present in retail stores at concentrations well below health guidelines. Indoor formaldehyde concentrations ranged from 4.6 ppb to 67 ppb. The two mid-sized grocery stores in the sample had the highest levels of ethanol and acetaldehyde, with concentrations up to 2.6 ppm and 92 ppb, respectively, possibly due to the preparation of dough and baking activities. Indoor-to-outdoor concentration ratios indicated that indoor sources were the main contributors to indoor VOC concentrations for the majority of compounds. There was no strong correlation between ventilation and VOC concentrations across all stores. However, increasing the air exchange rates at two stores led to lower indoor VOC concentrations, suggesting that ventilation can be used to reduce concentrations for some specific stores.

  7. Experimental fuel rod stored energy determination. STEED I project

    Energy Technology Data Exchange (ETDEWEB)

    Engman, U.; Malen, K. [Studsvik Nuclear AB, Nykoeping (Sweden)

    1999-06-01

    The objective of the STEED I (STored Energy/Enthalpy Determination) project was to evaluate an experimental method for producing accurate and reliable data concerning the stored energy in fuel rods during operation. The STEED data should provide useful information for LOCA evaluation, fuel design and thermo-mechanical modelling. Stored energy refers to the amount of heat, which at a certain time is stored within the fuel. Physical properties of the fuel that affect the quantity of stored energy are radial power profile, burnup, fuel geometry, fuel density and thermal conductivity and heat capacity of the fuel pellet, and the gas gap conductance. The quantity of stored energy is conveniently studied under transient conditions when all, or part of the stored heat is released. This work describes determination of the stored energy by evaluating scram tests. The R2 test reactor is well suited for this type of experiments, where the thermal response of different types of fuel rods can be evaluated and compared. Scrams have been performed with the intent to evaluate the fuel rod stored energy before the scram. Methods have been developed for evaluation of the stored energy from the scram response It was found that the time dependence for a large part of the heat release from the rod could be described by a single time constant. Evaluations of the time constant have been made from the data in different ways. The stored energy has been evaluated integrating the exponential decay. The integral of the exponential decay is the initial power multiplied by the time constant. This means that differences in the stored energy due to, for instance, rod properties or rod power dependence are best studied using the same time constant. The scram response was modelled with the TOODEE2 transient code. The calculations gave a time constant of about 4 s and very little power dependence. The experimental result is a time constant around 4 s. The small differences in the measurement results

  8. Conditional load and store in a shared memory

    Science.gov (United States)

    Blumrich, Matthias A; Ohmacht, Martin

    2015-02-03

    A method, system and computer program product for implementing load-reserve and store-conditional instructions in a multi-processor computing system. The computing system includes a multitude of processor units and a shared memory cache, and each of the processor units has access to the memory cache. In one embodiment, the method comprises providing the memory cache with a series of reservation registers, and storing in these registers addresses reserved in the memory cache for the processor units as a result of issuing load-reserve requests. In this embodiment, when one of the processor units makes a request to store data in the memory cache using a store-conditional request, the reservation registers are checked to determine if an address in the memory cache is reserved for that processor unit. If an address in the memory cache is reserved for that processor, the data are stored at this address.

  9. Wing/store flutter with nonlinear pylon stiffness

    Science.gov (United States)

    Desmarais, R. N.; Reed, W. H., III

    1980-01-01

    Recent wind tunnel tests and analytical studies show that a store mounted on a pylon with soft pitch stiffness provides substantial increase in flutter speed of fighter aircraft and reduces dependency of flutter on mass and inertia of the store. This concept, termed the decoupler pylon, utilizes a low frequency control system to maintain pitch alignment of the store during maneuvers and changing flight conditions. Under rapidly changing transient loads, however, the alignment control system may allow the store to momentarily bottom against a relatively stiff backup structure in which case the pylon stiffness acts as a hardening nonlinear spring. Such structural nonlinearities are known to affect not only the flutter speed but also the basic behavior of the instability. The influence of pylon stiffness nonlinearities or the flutter characteristics of wing mounted external stores is examined.

  10. From manager's emotional intelligence to objective store performance: Through store cohesiveness and sales-directed employee behavior

    NARCIS (Netherlands)

    Wilderom, C.P.M.; Hur, YounHee; Wiersma, Uco J.; Berg, van den Peter T.; Lee, Jaehoon

    2015-01-01

    The relationships among manager's emotional intelligence, store cohesiveness, sales-directed employee behavior, and objective store performance were investigated. Non-managerial sales employees of a large retail electronics chain in South Korea (N = 1611) rated the emotional intelligence of their ow

  11. Prognostic impact of hexokinase and glucose transporter expressions and clinicopathologic features related to F-18-FDG uptake in esophageal cancer

    NARCIS (Netherlands)

    Schreurs, Liesbeth M; Pultrum, Bareld B; Pavlov, Kirill; Pruim, Jan; Groen, Henk; Hollema, Harry; Plukker, John Theodorus

    2012-01-01

    39 Background: Elucidation of prognostic predictors based on biological viability may be useful for a better detection of patients with a high risk of relapse or death from esophageal cancer. METHODS: Maximum standardized uptake values (SUVmax) were measured in the preoperative 18F-FDG positron emis

  12. Visualisation of metastatic oesophageal and gastric cancer and prediction of clinical response to palliative chemotherapy using {sup 18}FDG PET

    Energy Technology Data Exchange (ETDEWEB)

    Lorenzen, S.; Peschel, C.; Lordick, F. [Dept. of Internal Medicine, Haematology/Medical Oncology, Technical Univ. Munich (Germany); Herrmann, K.; Wieder, H.; Schwaiger, M. [Dept. of Nuclear Medicine, Technical Univ. Munich (Germany); Weber, W.A.; Hennig, M. [Inst. for Medical Statistics and Epidemiology, Technical Univ. Munich (Germany); Ott, K. [Dept. of Surgery, Technical Univ. of Munich (Germany); Bredenkamp, R. [Munich Centre for Clinical Studies, Munich (Germany)

    2007-07-01

    Aim: This study assessed the value of {sup 18}F-deoxyglucose positron emission tomography (FDG-PET) for visualisation and early metabolic response assessment in metastatic gastro-oesophageal cancer. Patients, methods: Twenty-six patients who were treated for metastatic disease (20 adenocarcinomas, 6 squamous cell cancers) underwent FDG-PET before and two weeks after the onset of palliative chemotherapy with either oxaliplatin + 5-FU/LV or with docetaxel + capecitabine. PET results were validated according to clinical response based on RECIST criteria. Results: Twenty-four tumours (92%) could be visualised by FDG-PET and were also assessable by a second PET scan at 2 weeks. The 2 tumours that were not detectable by PET were both gastric cancers belonging to the non-intestinal subtype according to Lauren. Median time to progression and overall survival were not significantly different for metabolic responders and non-responders (6.3 vs 5.3 months and 14.1 vs 12.5 months, respectively). Conclusion: In this heterogeneous study population, FDG-PET had a limited accuracy in predicting clinical response. However, the metabolic response prediction was particularly good in the subgroup of patients with oesophageal squamous cell cancer. Therefore, FDG-PET and assessment of cancer therapy clearly merits further investigation in circumscribed patient populations with metastatic disease. (orig.)

  13. Diagnostic value of F18-FDG PET/CT in patients with the revised definition of fever of unknown origin

    DEFF Research Database (Denmark)

    Prakash, Vineet; Ketharanathan, Nagulabaskaran; Lorenz, Eleanor

    2009-01-01

    enhanced CT. The value of PET/CT in determining the underlying etiology of FUO was retrospectively evaluated by comparing the study findings with a final diagnosis. Final diagnosis was formulated by 6 month clinical, imaging, microbiological and histopathological follow up. When no cause was found...... by follow up, the negative study was considered a true negative. Results: Final diagnosis was made in 35/59 pts. Diagnosis was reached in 86% of these pts with an abnormal study but only in 14% of pts with a normal study. Underlying etiologies included vasculitides (14 pts), infectious foci (14 pts...

  14. Primary hepatic actinomycosis mimicking hepatic malignancy with metastatic lymph nodes by F-18 FDG PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Kong, Eun Jung [Yeungnam Univ. Medical School and Hospital, Daegu (Korea, Republic of)

    2016-03-15

    Hepatic involvement is usually secondary to abdominal actinomycosis infection. Symptom onset is typically subscute and the disease follows a chronic and indolent course. These lesions are called inflammatory pseudotumors and cannot be differentiated from malignant tumors by radiological examination alone. Laboratory tests showed mild anemia; hemoglobin 119 g/L, elevated white blood cell count of 23,060/mm{sup 3}, AST 33 U/L, ALT 45 U/L, and γ-GT 155 U/L.

  15. Rare Thyroid Cartilage and Diaphragm Metastases from Lung Cancer Visualized on F-18 FDG-PET/CT Imaging

    Directory of Open Access Journals (Sweden)

    Pelin Özcan Kara

    2011-08-01

    Full Text Available Positron emission tomography (PET with F-18 fluorodeoxyglucose (FDG has evolved as a useful imaging modality in the assessment of a variety of cancers, especially for tumor staging and post treatment monitoring. It provides metabolic information. Although, when used alone, relative lack of anatomic landmarks, is a major limitation of PET imaging, this limitation of PET imaging is overcome by the availability of integrated PET/CT imaging. PET and CT images are acquired in one procedure, yielding fused anatomical and functional data sets. Studies with integrated PET/CT imaging have shown promising results. In this case, we present an interesting integrated PET/CT imaging in a lung cancer patient with rare, diaphragm and thyroid cartilage metastases. (MIRT 2011;20:70-72

  16. Impact of radiation dose and standardized uptake value of (18)FDG PET on nodal control in locally advanced cervical cancer

    DEFF Research Database (Denmark)

    Ramlov, Anne; Kroon, Petra S; Jürgenliemk-Schulz, Ina M;

    2015-01-01

    by dose-maps from EBRT and IGABT. All PET/CT scans were re-evaluated and nodal maximal standard uptake value (SUVmax) was determined. Nodal failures were registered to planning scans and related to boosted nodes and treated volume. Relation between SUVmax and nodal control as well as the pattern...

  17. Prognostic Impact of Clinicopathological Features and Expression of Biomarkers Related to F-18-FDG Uptake in Esophageal Cancer

    NARCIS (Netherlands)

    Schreurs, L. M. A.; Smit, J. K.; Pavlov, K.; Pultrum, B. B.; Pruim, J.; Groen, Henk; Hollema, H.; Plukker, John Th. M.

    2014-01-01

    To analyze the association between pretreatment 18-F-fluoro-deoxyglucose (FDG) uptake and characteristics of aggressive tumor biology in predicting outcome in esophageal cancer (EC). Tumor FDG-uptake was measured by maximum standardized uptake values (SUVmax) in 47 patients undergoing esophagectomy

  18. The value of 18-FDG-PET for diagnosing and evaluating lymph node metastasis in primary breast cancer

    Institute of Scientific and Technical Information of China (English)

    LI Xiao-jun; WANG Ling; LING Rui; WANG Jing; LI Guo-quan

    2007-01-01

    Objective: To analyze the result of 18F-2-deoxy-2-fluoro-D-glucose-positron emission tomography (FDG-PET) in suspicious primary breast cancer patients and to evaluate its value for the surgery therapy. Methods: Total 36 patients suspected of breast neoplasm were enrolled into the research. The result was compared with the pathology result. The rate of missed diagnosis, the rate of misdiagnosis, the sensitivity and specificity were calculated and analyzed. Results: Compared with the pathology results, the misdiagnosis rate, the rate of missed diagnosis, the sensitivity and specificity of FDG-PET for breast cancer were 0%, 36.36%, 63.63% and 100%, respectively. To those who had a neoplasm no more than 2 cm in diameter, the rate of missed diagnosis was as high as 41.67 %. To 33 breast cancer patients, the misdiagnosis rate, the rare of missed diagnosis, the sensitivity and specificity for lymph node metastasis were 18.75%, 41.18%, 58.82% and 81.25%, respectively. Conclusion: FDG-PET has a perfect specificity and a considerable sensitivity to the primary breast neoplasm and similar to the lymph node metastasis diagnosis. It is an ideal choice for those patients with suspected breast cancer but reluctantly to receive a vulnerarious examination.

  19. The Use of F-18-FDG-PET/CT for Diagnosis and Treatment Monitoring of Inflammatory and Infectious Diseases

    NARCIS (Netherlands)

    Glaudemans, Andor W. J. M.; de Vries, Erik F. J.; Galli, Filippo; Dierckx, Rudi A. J. O.; Slart, Riemer H. J. A.; Signore, Alberto

    2013-01-01

    FDG-PET, combined with CT, is nowadays getting more and more relevant for the diagnosis of several infectious and inflammatory diseases and particularly for therapy monitoring. Thus, this paper gives special attention to the role of FDG-PET/CT in the diagnosis and therapy monitoring of infectious an

  20. Patterns of FDG uptake in stomach on F-18 FDG positron emission tomography: correlation with endoscopic findings

    Energy Technology Data Exchange (ETDEWEB)

    Chae, Min Jeong; Cheon, Gi Jeong; Lee, Sang Woo; Byun, Byung Hyun; Kim, Sung Eun; Kim, Yu Chul; Choi, Chang Woon; Lim, Sang Moo [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

    2005-10-15

    We often find variable degrees of FDG uptake and patterns in stomach, which can make difficult to distinguish physiologic uptake from pathologic uptake on FDG PET. The purpose of this study was to find out the significant findings of stomach on FDG PET. Thirty-eight patients who underwent both FDG PET and endoscopy within one week from Jun. 2003, to Aug. 2004 were included in this study. We reviewed 38 patients (18 for medical check up, 15 for work up of other malignancies, and 5 for the evaluation of stomach lesion). Their mean age was 56 years old (range:32 {approx} 79), men and women were 28 and 10, respectively. Two nuclear physicians evaluated five parameters on FDG PET findings of stomach with a consensus: 1) visual grades 2) maximum SUV (max.SUV) 3) focal 4) diffuse and 5) asymmetric patterns. We correlated the lesions of FDG PET findings of stomach with those of endoscopy. We considered more than equivocal findings on FDG PET as positive. The six of 38 patients were proven as malignant lesions by endoscopic biopsy and others were inflammatory lesions (ulcer in 3, chronic atrophic gastritis in 12, uncommon forms of gastritis in 5), non-inflammatory lesions (n=3), and normal stomach (n=9). By the visual analysis, malignant lesions had higher FDG uptake than the others. The max.SUV of malignant lesions was 7.95 {+-} 4.83 which was significantly higher than the other benign lesions (2.9 {+-} 0.69 in ulcer, 3.08 {+-} 1.2 in chronic atrophic gastritis, 3.2 {+-} 1.49 in uncommon forms of gastritis ( {rho} =0.044). In the appearance of stomach on FDG PET, malignant lesions were shown focal (5 of 6) and benign inflammatory lesions were shown diffuse (9 of 20) and asymmetric (14 of 20). Benign lesions and normal stomach were shown variable degrees of uptake and patterns. Some cases of benign inflammatory lesions such as ulcer and gastritis were shown focal and mimicked cancerous lesions (4 of 15). Gastric malignant lesions had higher FDG uptake and focal pattern. However, benign inflammatory lesions had moderate degrees of uptake and diffuse and asymmetric patterns rather than focal. It is difficult to differentiate between benign lesions including normal.

  1. Experience of Dual Time Point Brain F-18 FDG PET/CT Imaging in Patients with Infections Disease

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dae Weung; Kim, Chang Guhn; Park, Soon Ah; Jung, Sang Ah [Wonkwang University School of Medicine, Iksan (Korea, Republic of)

    2010-06-15

    Dual time point FDG PET imaging (DTPI) has been considered helpful for discrimination of benign and malignant disease, and staging lymph node status in patients with pulmonary malignancy. However, DTPI for benign disease has been rarely reported, and it may show a better description of metabolic status and extent of benign infection disease than early imaging only. The authors report on the use F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) imaging with additional delayed imaging on a 52-year-old man with sparganosis and a 70-year-old man with tuberculous meningitis. To the best of our knowledge, this is the first report on dual time point PET/CT imaging in patients with cerebral sparganosis and tuberculous meningitis.

  2. Peripheral tuberculous lymphadenitis masquerading as metastatic gastric carcinoma on F 18 FDG dual time point PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Su Kon; Shin, Jeong Eun; Lee, Jai Hyuen [Dankook Univ. College of Medicine, Cheonan (Korea, Republic of)

    2012-12-15

    A 59 year old woman was hospitalized with weight loss, anorexia, and low grade fever for 2 weeks. she had under gone a total gastrectomy followed by adjuvant chemotherapy 10 years prior due to advanced gastric cancer to evaluate recurrence, fluorine 19 fluorodeoxyglucose (FDG) dual time point positron emission tomography/computed tomography (DTPP) was conducted with a gemini GXL 6 PET/CT system (Philips, Hamburg, Germany). FDG DTPP was performed twice, with an early scan 60 min after FDG injection and a delayed scan 150min after FDG injection. The early scan showed that multiple hypermetabolic lesions were located along left supraclavicular, mediastinal (1R, 2R, 3, 4R and 7) and left paraaortic (retroperitoneal) nodal stations. The delayed scan showed that all the above mentioned lesions revealed a more increased maximal standard uptake value (SUVmax) than was detected in the early scan. both scans did not show intrapulmonary lesion. For example, the left supraclavicular lymph node, 2R and retroperitoneal lymph node were observed with early and delayed SUV maxes of 4.5/7.6/3.6 and 6.7/7.7/3.6 and 6.7/10.7/4.4, respectively. Tom confirm diagnosis and establish a treatment plan, a mediastinoscopic biopsy of one of the mediastinal lymph nodes (4R) was subsequently performed and tuberculosis was ultimately diagnosed. Then, the patient started an antituberculosis treatment instead of antichemotherapy. A follow up FDG PET/CT performed 12 months later showed disappeared FDG uptake and significant decreased change of multiple peripheral tuberculous lymphadenitis. Whole body FDG PET/CT has widespread use in diagnosing and staging variable malignancies, and plays an important role in detection of gastric cancer recurrence. However, FDG is not cancer specific and some inflammatory diseases have shown higher FDG uptake on PET imaging. Infection, inflammation, and granulomatosis are also known to cause false positive FDG PET scans because activated inflammatory cells show avidity for FDG. So, for alternative measure differentiating malignancy from benign disease, early standard FDG PET/CT and delayed scan after early scan, namely FDG DTPP, has been introduced and often performed worldwide. FDG DTPP used the phenomenon that with time, FDG uptake in normal or benign tissues decreases. Although FDG DTPP has been not accepted routinely, the retention index inferred from FDG DTPP predicted patient prognosis in lung cancer. We had considered multiple hypermetabolic lymph nodes as metastasis rather than benign lymphadenopathies because of increased FDG uptake on the delayed scan versus the early scan, before pathologic results were confirmed. It is presumed that FDG DTPP could not help differentiate malignancy from benign diseases in cases of active infectious disease such as ongoing tuberculosis. Peripheral tuberculous lymphadenitis (PTL) is a common manifestation of extrapulmonary tuberculosis and remains an important cause of adenopathy globally. It was difficult for those lesions to be directly considered as PTL, because PTL manifestation mainly involves cervical chains and the supraclavicular region.

  3. False-positive axillary lymph node on F-18 FDG PET/CT due to moxibustion therapy

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Shin Young; Lee, Sang Woo; Ahn, Byeong Cheol; Lee, Jae Tae [Kyungpook National University Hospital, Daegu (Korea, Republic of); Seo, Ji Hyoung [Inje University Haeundae Paik Hospital, Busan (Korea, Republic of)

    2010-12-15

    A 30-year-old female was diagnosed with papillary thyroid cancer and underwent total thyroidectomy and high-dose radioiodine ablation. F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for recurrence detection of thyroid carcinoma was performed at 3 years after total thyroidectomy. Moxibustion is a traditional Chinese medicine therapy using moxa or the mugwort herb. Moxibustion is the burning of a small, thimble-sized, smoldering plug of dried leaves such as moxa or mugwort on the skin at an acupuncture point. Acupuncture and moxibustion induce hyperemia and a local inflammatory reaction. Complications associated with moxibustion such as skin bums or infection of the site have been reported previously. False-positive FDG uptake in PET may result from inflammation, infection, and variations in physiological uptake. In the present case, the hypermetabolic axillary lymph node disappeared without any treatment. Well-known of false-positive FDG uptake in axillary lymph noes such as arthritis of the upper extremity, extravasation of injected FDG, and vaccination were not found. Thus, left axillary lymph node uptake was

  4. SUVmax of 18FDG PET/CT as a predictor of high-risk endometrial cancer patients

    DEFF Research Database (Denmark)

    Antonsen, Sofie Leisby; Loft, Annika; Fisker, Rune Vincents;

    2013-01-01

    To evaluate SUVmax in the assessment of endometrial cancer preoperatively with particular focus on myometrial invasion (MI), cervical invasion (CI), FIGO stage, risk-stratification and lymph node metastases (LNM).......To evaluate SUVmax in the assessment of endometrial cancer preoperatively with particular focus on myometrial invasion (MI), cervical invasion (CI), FIGO stage, risk-stratification and lymph node metastases (LNM)....

  5. Impact of radiation dose and standardized uptake value of (18)FDG PET on nodal control in locally advanced cervical cancer

    DEFF Research Database (Denmark)

    Ramlov, Anne; Kroon, Petra S; Jürgenliemk-Schulz, Ina M;

    2015-01-01

    BACKGROUND: Despite local control now exceeding 90% with image-guided adaptive brachytherapy (IGABT), regional and distant metastases continue to curb survival in locally advanced cervical cancer. As regional lymph nodes often represent first site of metastatic spread, improved nodal control could...... is a negative prognostic predictor for nodal control. Attention should be raised to administration of a complete schedule of concurrent chemotherapy as well as treatment of para-aortic nodes....

  6. Non-invasive Estimation of Metabolic Uptake Rate of Glucose using F18-FDG PET and Linear Transformation of Outputs

    DEFF Research Database (Denmark)

    Christensen, Anders Nymark; Reichkendler, M.; Auerback, P.;

    based on one common tissue curve against all the IDIFs. When compared to ABS Km values, an underestimation was found for all methods. Using ordinary least squares estimation on the ABS Km values vs. the IDIF Km a calibration factor and term was identified for each method and used for transformation....... The Mean Squared Error (MSE) was determined for the different methods before transformation, and estimated by N-fold cross validation and .632+ bootstrapping after transformation. Further, since ordinary least squares is an unbiased estimator we could use the estimated MSE to determine the standard...... deviation of the different unbiased methods after transformation using the relation MSE(θ) = variance(θ)+bias(θ)^2. Results: All methods performed poorly before transformation, except one described by Backes et al.. After transformation all methods yields unbiased Km based on the IDIF alone but have...

  7. Comparing Relational and Ontological Triple Stores in Healthcare Domain

    Directory of Open Access Journals (Sweden)

    Ozgu Can

    2017-01-01

    Full Text Available Today’s technological improvements have made ubiquitous healthcare systems that converge into smart healthcare applications in order to solve patients’ problems, to communicate effectively with patients, and to improve healthcare service quality. The first step of building a smart healthcare information system is representing the healthcare data as connected, reachable, and sharable. In order to achieve this representation, ontologies are used to describe the healthcare data. Combining ontological healthcare data with the used and obtained data can be maintained by storing the entire health domain data inside big data stores that support both relational and graph-based ontological data. There are several big data stores and different types of big data sets in the healthcare domain. The goal of this paper is to determine the most applicable ontology data store for storing the big healthcare data. For this purpose, AllegroGraph and Oracle 12c data stores are compared based on their infrastructural capacity, loading time, and query response times. Hence, healthcare ontologies (GENE Ontology, Gene Expression Ontology (GEXO, Regulation of Transcription Ontology (RETO, Regulation of Gene Expression Ontology (REXO are used to measure the ontology loading time. Thereafter, various queries are constructed and executed for GENE ontology in order to measure the capacity and query response times for the performance comparison between AllegroGraph and Oracle 12c triple stores.

  8. Sodium in Store and Restaurant Food Environments - Guam, 2015.

    Science.gov (United States)

    Jackson, Sandra L; VanFrank, Brenna K; Lundeen, Elizabeth; Uncangco, Alyssa; Alam, Lawrence; King, Sallyann M Coleman; Cogswell, Mary E

    2016-01-01

    Compared with the United States overall, Guam has higher mortality rates from cardiovascular disease and stroke (1). Excess sodium intake can increase blood pressure and risk for cardiovascular disease (2,3). To determine the availability and promotion of lower-sodium options in the nutrition environment, the Guam Department of Public Health and Social Services (DPHSS) conducted an assessment in September 2015 using previously validated tools adapted to include sodium measures. Stores (N = 114) and restaurants (N = 63) were randomly sampled by region (north, central, and south). Data from 100 stores and 62 restaurants were analyzed and weighted to account for the sampling design. Across the nine product types assessed, lower-sodium products were offered less frequently than regular-sodium products (p<0.001) with <50% of stores offering lower-sodium canned vegetables, tuna, salad dressing, soy sauce, and hot dogs. Lower-sodium products were also less frequently offered in small stores than large (two or more cash registers) stores. Reduced-sodium soy sauce cost more than regular soy sauce (p<0.001) in stores offering both options in the same size bottle. Few restaurants engaged in promotion practices such as posting sodium information (3%) or identifying lower-sodium entrées (1%). Improving the availability and promotion of lower-sodium foods in stores and restaurants could help support healthier eating in Guam.

  9. Effective Factors in Environmental Health Status of Grocery Stores

    Directory of Open Access Journals (Sweden)

    Mehdi Asadi

    2012-08-01

    Full Text Available Aims of the Study: This study was carried out to determine the effective factors in environmental health status of grocery stores in the city of Qom (located in the center of Iran. Materials & Methods: In this cross-sectional study, 283 grocery stores from 3 different regions were selected randomly using stratified sampling. Data were gathered through observation, interview, and questionnaire. The questionnaire consisted of two sections: section 1 dealt with some shop managers’ features including the age, educational level, job satisfaction, passing “food and occupational hygiene training courses”, store ownership, duration of employment, and features of stores including their location (Region and environmental health condition. And section 2 dealt with the important aspects of regulations of Article 13. The data analyzed using statistical procedures such as Spearman Rank Correlation and Multivariate Regression Analysis. P-values less than 0.05 were considered as statistically significant. Results: Among the investigated factors, the manager’s educational level had a greater impact on the environmental health conditions of grocery stores. The ownership status of grocery stores, Job satisfaction and passing “food and occupational hygiene training courses” were next in the ranking, respectively (p <0.001 for all measures, except for shop ownership, for which p-value was <0.02. Conclusions: Planning and implementation of effective operational and strategic programs addressing the above mentioned issues seems to be necessary. Such programs will improve the health status of the stores over time.

  10. Snack food advertising in stores around public schools in Guatemala.

    Science.gov (United States)

    Chacon, Violeta; Letona, Paola; Villamor, Eduardo; Barnoya, Joaquin

    Obesity in school-age children is emerging as a public heath concern. Food marketing influences preferences and increases children's requests for food. This study sought to describe the type of snack foods advertised to children in stores in and around public schools and assess if there is an association between child-oriented snack food advertising and proximity to schools. All food stores located inside and within a 200 square meter radius from two preschools and two primary schools were surveyed. We assessed store type, number and type of snack food advertisements including those child-oriented inside and outside stores. We surveyed 55 stores and found 321 snack food advertisements. Most were on sweetened beverages (37%) and soft drinks (30%). Ninety-two (29%) were child-oriented. Atoles (100.0%), cereals (94.1%), and ice cream and frozen desserts (71.4%) had the greatest proportion of child-oriented advertising. We found more child-oriented advertisements in stores that were closer (advertisements are available in almost all stores within a short walking distance from schools, exposing children to an obesogenic environment.

  11. Systems and methods of storing combustion waste products

    Science.gov (United States)

    Chen, Shen-En; Wang, Peng; Miao, Xiexing; Feng, Qiyan; Zhu, Qianlin

    2016-04-12

    In one aspect, methods of storing one or more combustion waste products are described herein. Combustion waste products stored by a method described herein can include solid combustion waste products such as coal ash and/or gaseous combustion products such as carbon dioxide. In some embodiments, a method of storing carbon dioxide comprises providing a carbon dioxide storage medium comprising porous concrete having a macroporous and microporous pore structure and flowing carbon dioxide captured from a combustion flue gas source into the pore structure of the porous concrete.

  12. Labor Regulation and Employment in India's Retail Stores

    OpenAIRE

    Amin, Mohammad

    2007-01-01

    A new dataset of 1,948 retail stores in India shows that 27 percent of the stores find labor regulations as a problem for their business. Using these data, author analyzes the effect of labor regulations on employment at thestore level. The author foound that flexible labor regulations have a strong positive effect on job creation. The author estimates show that labor reforms are likely to increase employment by 22 percent of the current level for an average store. The author also addresses t...

  13. GSM accessories now available from the CERN Stores

    CERN Multimedia

    Labo Telecom

    2001-01-01

    As of 1st October you can order and receive GSM accessories from the CERN stores like any other article. The CERN stores also manage GSM telephones but, for technical reasons, only the Labo Telecom shop (Building 31, Room S026) is able to make the standard sales, repairs and exchanges for authorised persons with a CERN subscription. Labo Telecom will thus become a specialist shop, open from 11 a.m. to 12 a.m., and will apply the usual rules and authorisation procedures of the stores. The paper form for requests for GSM subscriptions is being computerized and will be available on EDH in the near future.

  14. Using of simulation for comparison of technologies for pallets storing

    Science.gov (United States)

    Kříž, Pavel; Chramcov, Bronislav; Jemelka, Milan

    2016-06-01

    The paper highlights the problem oftechnology for pallet storing. The aim is to compare selected technologies and to find efficient warehouse solution for the real company, which produces a plastic parts for automotive and needs to solve storing in the new hall. The work describes differences between two pallet storing technologies - static racking system and powered mobile racking system. Comparison contains description, advantages and disadvantages of the both systems. Real data from real project are used for the evaluation of necessary parameters. The result presents proposal of solution which can meet all initial conditions.

  15. Polarizing a stored proton beam by spin flip?

    CERN Document Server

    Oellers, D; Barsov, S; Bechstedt, U; Benati, P; Bertelli, S; Chiladze, D; Ciullo, G; Contalbrigo, M; Dalpiaz, P F; Dietrich, J; Dolfus, N; Dymov, S; Engels, R; Erven, W; Garishvili, A; Gebel, R; Goslawski, P; Grigoryev, K; Hadamek, H; Kacharava, A; Khoukaz, A; Kulikov, A; Langenberg, G; Lehrach, A; Lenisa, P; Lomidze, N; Lorentz, B; Macharashvili, G; Maier, R; Martin, S; Merzliakov, S; Meshkov, I N; Meyer, H O; Mielke, M; Mikirtychiants, M; Mikirtychiants, S; Nass, A; Nekipelov, M; Nikolaev, N N; Nioradze, M; d'Orsaneo, G; Papenbrock, M; Prasuhn, D; Rathmann, F; Sarkadi, J; Schleichert, R; Smirnov, A; Seyfarth, H; Sowinski, J; Spoelgen, D; Stancari, G; Stancari, M; Statera, M; Steffens, E; Stein, H J; Stockhorst, H; Straatmann, H; Ströher, H; Tabidze, M; Tagliente, G; Engblom, P Thoerngren; Trusov, S; Vasilyev, A; Weidemann, Chr; Welsch, D; Wieder, P; Wüstner, P; Zupranski, P

    2009-01-01

    We discuss polarizing a proton beam in a storage ring, either by selective removal or by spin flip of the stored ions. Prompted by recent, conflicting calculations, we have carried out a measurement of the spin flip cross section in low-energy electron-proton scattering. The experiment uses the cooling electron beam at COSY as an electron target. The measured cross sections are too small for making spin flip a viable tool in polarizing a stored beam. This invalidates a recent proposal to use co-moving polarized positrons to polarize a stored antiproton beam.

  16. Store-operated calcium channels and pro-inflammatory signals

    Institute of Scientific and Technical Information of China (English)

    Wei-chiao CHANG

    2006-01-01

    In non-excitable cells such as T lymphocytes,hepatocytes,mast cells,endothelia and epithelia,the major pathway for calcium(Ca2+)entry is through store-operated Ca2+ channels in the plasma membrane.These channels are activated by the emptying of intracellular Ca2+ stores,however,neither the gating mechanism nor the downstream targets of these channels has been clear established.Here,I review some of the proposed gating mechanisms of store-operated Ca2+ channels and the functional implications in regulating pro-inflammatory signals.

  17. Biorational approaches to managing stored-product insects.

    Science.gov (United States)

    Phillips, Thomas W; Throne, James E

    2010-01-01

    Stored-product insects can cause postharvest losses, estimated from up to 9% in developed countries to 20% or more in developing countries. There is much interest in alternatives to conventional insecticides for controlling stored-product insects because of insecticide loss due to regulatory action and insect resistance, and because of increasing consumer demand for product that is free of insects and insecticide residues. Sanitation is perhaps the first line of defense for grain stored at farms or elevators and for food-processing and warehouse facilities. Some of the most promising biorational management tools for farm-stored grain are temperature management and use of natural enemies. New tools for computer-assisted decision-making and insect sampling at grain elevators appear most promising. Processing facilities and warehouses usually rely on trap captures for decision-making, a process that needs further research to optimize.

  18. Storing, Transporting and Disposing of Mercury in Your Home

    Science.gov (United States)

    ... Topics: Mercury in Your Environment Share Facebook Twitter Google+ Pinterest Contact Us Storing, Transporting and Disposing of ... of a pick-up truck or in your car's trunk. If you must transport in the passenger ...

  19. Management of Constraint Generators in Fashion Store Design Processes

    DEFF Research Database (Denmark)

    Borch Münster, Mia; Haug, Anders

    2017-01-01

    Purpose: Retail design concepts are complex designs meeting functional and aesthetic demands from various constraint generators. However, the literature on this topic is sparse and offers only little support for store designers to deal with such challenges. To address this issue, the purpose...... is on fashion store design, the findings may, to some degree, be applicable to other types of store design projects. Practical implications: The understandings provided by this paper may help designers to deal proactively with constraints, reducing the use of resources to alter design proposals. Originality....../value: The paper: defines the most important constraint generators from the perspective of retail store designers, clarifies the types of constraints they generate, and provides guidelines for how to deal with constraint elicitation....

  20. College Stores and Computers and Students and Faculty.

    Science.gov (United States)

    Newcomb, Jack, Ed.

    1982-01-01

    Information on the computer industry and computer use by students, faculty, and the publishing industry that may be useful in planning college store merchandising is compiled from a variety of sources. (MSE)

  1. Evaluating Digital Strategies for Storing and Retrieving Scholarly Information.

    Science.gov (United States)

    Getz, Malcolm

    1997-01-01

    Outlines the advantages of digital documents for scholars and offers considerations for designing systems for storing and retrieving digital information products. Discusses conventional and electronic storage and retrieval; network costs; digital storage; search strategies; acquisition prices; and digital initiatives. (AEF)

  2. Associative Models for Storing and Retrieving Concept Lattices

    Directory of Open Access Journals (Sweden)

    María Elena Acevedo

    2010-01-01

    Full Text Available Alpha-beta bidirectional associative memories are implemented for storing concept lattices. We use Lindig's algorithm to construct a concept lattice of a particular context; this structure is stored into an associative memory just as a human being does, namely, associating patterns. Bidirectionality and perfect recall of Alpha-Beta associative model make it a great tool to store a concept lattice. In the learning phase, objects and attributes obtained from Lindig's algorithm are associated by Alpha-Beta bidirectional associative memory; in this phase the data is stored. In the recalling phase, the associative model allows to retrieve objects from attributes or vice versa. Our model assures the recalling of every learnt concept.

  3. Quality-aware scheduling for key-value data stores

    CERN Document Server

    Xu, Chen

    2015-01-01

    This book comprehensively illustrates quality-ware scheduling in key-value stores. In addition, it provides scheduling strategies and a prototype framework of quality-aware scheduler as well as a demonstration of online applications. The book offers a rich blend of theory and practice which is suitable for students, researchers and practitioners interested in distributed systems, NoSQL key-value stores and scheduling.

  4. Can spoilage bacteria cause blackspot (melanosis) in stored prawns?

    DEFF Research Database (Denmark)

    Chinivasagam, H.N.; Bremner, Allan; Reeves, R.

    1998-01-01

    Several isolates of Pseudomonas fragi can metabolize tyrosine to produce a red-brown colour within 8-10 days when incubated (5 degrees C) in artificial media. It is possible that bacterial production of melanin occurs on stored prawns.......Several isolates of Pseudomonas fragi can metabolize tyrosine to produce a red-brown colour within 8-10 days when incubated (5 degrees C) in artificial media. It is possible that bacterial production of melanin occurs on stored prawns....

  5. Toxigenic fungi in corn (maize stored in hermetic plastic bags

    Directory of Open Access Journals (Sweden)

    Castellari, C.

    2010-09-01

    Full Text Available In Argentina, 35 million tonnes are stored in hermetic plastic bags. Inside the bags, the modified atmosphere has an effect on stored grains, insects and fungi. Fungi taxa and species typically isolated from stored grains consist of species of the genera Aspergillus, Penicillium, Fusarium and xerophilic fungi, some of which are potential producers of mycotoxins. The province of Entre Rios, Argentina, is an important area of study because much of the production of maize stored in bags is supplying the poultry industry demand. The objective of this study was to identify mycotoxigenic fungi species in maize stored in hermetic plastic bags, located in three Departments of Entre Rios province. A total of 176 samples of maize were analyzed, stored in 23 bags located in the Departments of Paraná (west region, La Paz (northern region and Tala (central region. Two potential producers of aflatoxins (A. flavus and A. parasiticus and a potential producer of fumonisins (F. verticillioides were identified in all the plastics bags evaluated. In La Paz Department, Aspergillus spp. and F. verticillioides were detected in 66.7% and 54% of samples, respectively. In Tala Department, Aspergillus spp. were detected in 63.3% and F. verticillioides in 43.6%, while in Parana, Aspergillus spp. was detected in 88.2% of the evaluated samples and F. verticillioides in 41.4% of the samples. The results revealed that mycotoxigenic fungi can develop in maize stored in hermetic plastic bags. This implies a potential risk of contamination with aflatoxins and /or fumonisins in the grain lots stored inside these bags.

  6. Virulence of Entomopathogenic Fungi and Bacteria against Stored Product Pests

    OpenAIRE

    Sevim, Ali; Sevim, Elif; Demirci, Meryem

    2015-01-01

    Virulence of Entomopathogenic Fungi and Bacteria against Stored Product PestsEntomopathogenic microorganisms such as bacteria, fungi, viruses, nematodes and protozoa play an important role for regulation of insect pest populations and, this leads to use these microorganisms as biological control agents against pest species as an alternative to chemicals insecticides. In this study, we tested different bacteria originated from stored product pests and fungi isolated from different sources agai...

  7. Benzodiazepine stability in postmortem samples stored at different temperatures.

    Science.gov (United States)

    Melo, Paula; Bastos, M Lourdes; Teixeira, Helena M

    2012-01-01

    Benzodiazepine (lorazepam, estazolam, chlordiazepoxide, and ketazolam) stability was studied in postmortem blood, bile, and vitreous humor stored at different temperatures over six months. The influence of NaF, in blood and bile samples, was also investigated. A solid-phase extraction technique was used on all the studied samples, and benzodiazepine quantification was performed by high-performance liquid chromatography-diode-array detection. Benzodiazepine concentration remained almost stable in all samples stored at -20°C and -80°C. Estazolam appeared to be a stable benzodiazepine during the six-month study, and ketazolam proved to be the most unstable benzodiazepine. A 100% loss of ketazolam occurred in all samples stored over 1 or 2 weeks at room temperature and over 8 or 12 weeks at 4°C, with the simultaneous detection of diazepam. Chlordiazepoxide suffered complete degradation in all samples, except preserved bile samples, stored at room temperature. Samples stored at 4°C for 6 months had a 29-100% decrease in chlordiazepoxide concentration. The data obtained suggest that results from samples with these benzodiazepines stored long-term should be cautiously interpreted. Bile and vitreous humor proved to be the most advantageous samples in cases where degradation of benzodiazepines by microorganisms may occur.

  8. Modified expression of surface glyconjugates in stored human platelets

    Energy Technology Data Exchange (ETDEWEB)

    Dhar, A.; Ganguly, P.

    1987-05-01

    Platelets are anucleated cells which play an important part in blood coagulation and thrombosis. These cells may be stored in the blood bank for only 4/5 days. In order to improve the storage of platelets, it is essential to first understand the changes in these cells due to storage. In this work, human platelets were stored in autologous plasma at 4/sup 0/ or 22/sup 0/ and their surface changes were monitored with three lectins - wheat germ afflutinin (WGA), concanavalin A (Con A) and lentil lectin (LL). Blood was drawn from healthy donors and platelet rich plasma (PRP) was collected by slow speed centrifugation. Platelets stored at either temperature for different times showed increased sensitivity to agglutination by WGA after 34-48 hrs. Lectins, Con A and LL, which were not agglutinating to fresh platelets readily caused agglutination after 48-72 hrs. The platelets stored for 25 hrs or longer period were insensitive to thrombin but showed enhanced aggregation with WGA. Labelling of surface glycoconjugates of stored platelets with /sup 3/H-boro-hydride revealed progressive loss of a glycoprotein of Mr 150,000 (GPIb infinity) together with the appearance of components of Mr 69,000; Mr 60,000; Mr 25,000. New high molecular weight glycoproteins were also detected only in stored platelets. The author studies clearly indicate that modification or altered expression of platelets surface glycoproteins may be one factor of storage related dysfunction of platelets.

  9. PROPENSITY TO CUSTOMER SWITCHING: A REVIEW ON APPAREL STORES

    Directory of Open Access Journals (Sweden)

    Chaminda Karunaratna

    2015-12-01

    Full Text Available In the contemporary marketplace, customer switching has become a popularly addressed phenomenon. This study endeavoured to provide an approach to understand the customer switching behaviour and identify the major factors which influence customer switching in apparel stores. Clothing has become a major requirement for each and every customer in this modern society. Customers use their preferred brand, material and style etc. and become loyal to particular apparel store/s where they can enjoy the expected benefits in choosing preferred clothing items. However, customers may switch their apparel stores due to various reasons. Even though many clothing brands at different quality and price levels are available, many customers still switch among different apparel stores. In the field of apparel industry, researchers have put more weight on the fashion clothing, nature of purchasing decisions, and clothing brand loyalty etc. Howeevr, the research studies which focus on customer switching is scarce.Therefore, this study attempts to study the factors which cause customer switching in appreal stores. The survey method was adopted as the main research method to conduct the study. The sample consisted of 300 customers who were met at their visits to textile shops in the city of Matara in Sri Lanka. An exploratory factor analysis was employed to identify the major factors of customer switching. According to the results of the exploratory factor analysis, five major factors such as inferior quality, unavailability, service failure, stressful atmosphere and high price were identified as the major factors which influence the switching decision in retail apparel store.

  10. Pressure Systems Stored-Energy Threshold Risk Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Paulsen, Samuel S.

    2009-08-25

    Federal Regulation 10 CFR 851, which became effective February 2007, brought to light potential weaknesses regarding the Pressure Safety Program at the Pacific Northwest National Laboratory (PNNL). The definition of a pressure system in 10 CFR 851 does not contain a limit based upon pressure or any other criteria. Therefore, the need for a method to determine an appropriate risk-based hazard level for pressure safety was identified. The Laboratory has historically used a stored energy of 1000 lbf-ft to define a pressure hazard; however, an analytical basis for this value had not been documented. This document establishes the technical basis by evaluating the use of stored energy as an appropriate criterion to establish a pressure hazard, exploring a suitable risk threshold for pressure hazards, and reviewing the methods used to determine stored energy. The literature review and technical analysis concludes the use of stored energy as a method for determining a potential risk, the 1000 lbf-ft threshold, and the methods used by PNNL to calculate stored energy are all appropriate. Recommendations for further program improvements are also discussed

  11. Providing a Foundation for Analysis of Volatile Data Stores

    Directory of Open Access Journals (Sweden)

    Timothy Vidas

    2007-09-01

    Full Text Available Current threats against typical computer systems demonstrate a need for forensic analysis of memory-resident data in addition to the conventional static analysis common today.  Certain attacks and types of malware exist solely in memory and leave little or no evidentiary information on nonvolatile stores such as a hard disk drive.  The desire to preserve system state at the time of response may even warrant memory acquisition independent of perceived threats and the ability to analyze the acquired duplicate. Tools capable of duplicating various types of volatile data stores are becoming widely available.  Once the data store has been duplicated, current forensic procedures have no method for extrapolating further useful information from the duplicate.  This paper is focused on providing the groundwork for performing forensic investigations on the data that is typically stored in a volatile data store, such as system RAM.It is intended that, when combined with good acquisition techniques, it will be shown that it is possible to obtain more post incident response information along with less impact to potential evidence when compared to typical incident response procedures. 

  12. Resveratrol preserves the function of human platelets stored for transfusion.

    Science.gov (United States)

    Lannan, Katie L; Refaai, Majed A; Ture, Sara K; Morrell, Craig N; Blumberg, Neil; Phipps, Richard P; Spinelli, Sherry L

    2016-03-01

    Stored platelets undergo biochemical, structural and functional changes that lead to decreased efficacy and safety of platelet transfusions. Not only do platelets acquire markers of activation during storage, but they also fail to respond normally to agonists post-storage. We hypothesized that resveratrol, a cardioprotective antioxidant, could act as a novel platelet storage additive to safely prevent unwanted platelet activation during storage, while simultaneously preserving normal haemostatic function. Human platelets treated with resveratrol and stored for 5 d released less thromboxane B2 and prostaglandin E2 compared to control platelets. Resveratrol preserved the ability of platelets to aggregate, spread and respond to thrombin, suggesting an improved ability to activate post-storage. Utilizing an in vitro model of transfusion and thromboelastography, clot strength was improved with resveratrol treatment compared to conventionally stored platelets. The mechanism of resveratrol's beneficial actions on stored platelets was partly mediated through decreased platelet apoptosis in storage, resulting in a longer half-life following transfusion. Lastly, an in vivo mouse model of transfusion demonstrated that stored platelets are prothrombotic and that resveratrol delayed vessel occlusion time to a level similar to transfusion with fresh platelets. We show resveratrol has a dual ability to reduce unwanted platelet activation during storage, while preserving critical haemostatic function.

  13. Partitioned key-value store with atomic memory operations

    Science.gov (United States)

    Bent, John M.; Faibish, Sorin; Grider, Gary

    2017-02-07

    A partitioned key-value store is provided that supports atomic memory operations. A server performs a memory operation in a partitioned key-value store by receiving a request from an application for at least one atomic memory operation, the atomic memory operation comprising a memory address identifier; and, in response to the atomic memory operation, performing one or more of (i) reading a client-side memory location identified by the memory address identifier and storing one or more key-value pairs from the client-side memory location in a local key-value store of the server; and (ii) obtaining one or more key-value pairs from the local key-value store of the server and writing the obtained one or more key-value pairs into the client-side memory location identified by the memory address identifier. The server can perform functions obtained from a client-side memory location and return a result to the client using one or more of the atomic memory operations.

  14. The retail store managers' role: Evidence from Greece

    Directory of Open Access Journals (Sweden)

    Zairis, A.

    2013-03-01

    Full Text Available Despite the fact that the retail manager's role is determinant for a store's performance, and there is abundant wisdom about how to be an outstanding manager or what are the characteristics of a successful retail manager, there is no detailed description about the store managers' role or their actual work. Furthermore, the continuous developments in the retail sector have established different roles and created higher levels of responsibility for store managers. The aim of the present paper is to empirically investigate the role of retail store managers in Greece and identify any potential differences in terms of personal characteristics, tasks and various job-related factors. For the purposes of this research a survey was conducted focusing on the sectors of apparel/footwear and food, in an attempt to explore any potential differences within the two divisions. The results revealed the profile of the Greek store managers (male, over the age of 40, with a secondary level of education and more than five years of work experience and their multi-factor role. The three major roles that they perform were labeled as: sales oriented, supervisor, and customer experience oriented. The research also indicated that the two most popular sub-sectors in the Greek retail industry employ different profile managers. The issues of work experience, job satisfaction and security were also analysed.

  15. Real-time video analysis for retail stores

    Science.gov (United States)

    Hassan, Ehtesham; Maurya, Avinash K.

    2015-03-01

    With the advancement in video processing technologies, we can capture subtle human responses in a retail store environment which play decisive role in the store management. In this paper, we present a novel surveillance video based analytic system for retail stores targeting localized and global traffic estimate. Development of an intelligent system for human traffic estimation in real-life poses a challenging problem because of the variation and noise involved. In this direction, we begin with a novel human tracking system by an intelligent combination of motion based and image level object detection. We demonstrate the initial evaluation of this approach on available standard dataset yielding promising result. Exact traffic estimate in a retail store require correct separation of customers from service providers. We present a role based human classification framework using Gaussian mixture model for this task. A novel feature descriptor named graded colour histogram is defined for object representation. Using, our role based human classification and tracking system, we have defined a novel computationally efficient framework for two types of analytics generation i.e., region specific people count and dwell-time estimation. This system has been extensively evaluated and tested on four hours of real-life video captured from a retail store.

  16. Biochemical lesions of platelets stored as concentrates in PVC bags.

    Science.gov (United States)

    Krishnan, L K; Mathai, J; Sulochana, P V; Jacob, J; Sivakumar, R

    1997-02-01

    Acid-base status of platelet suspension during storage is a measure of the gas permeability of the bag material. To assess the efficacy of the bags available in our market to store platelets, we compared biochemical lesions of platelets stored in an Indian polyvinyl chloride (PVC) triple bag against a Japanese PVC bag standardized for 5 days platelet storage. Platelet concentrates prepared in both control and test PVC bags were stored for 72 h. Two ml samples were drawn 1 h after preparation, and then at 24 h intervals, for analysis. Our data show that the mean pH value in the test bags was maintained above 6.5. However, the CO2 tension was high and O2 tension was low. We also analyzed malondialdehyde (MDA) formation which is a measure of arachidonic acid metabolism, and seemed to be unaffected in stored platelets. Lactate dehydrogenase (LDH) was not released into the plasma excessively and hence significant platelet lysis was absent during storage. Hypotonic shock response (HSR) of platelets stored in both test and control bags was comparable, indicating the possibility of satisfactory post-transfusion recovery.

  17. The quality of sweet cherries stored under hypobaric conditions

    Directory of Open Access Journals (Sweden)

    H. Borecka

    2013-12-01

    Full Text Available Sweet cherries cvs 'Emperor Francis' and 'Grosse Schwarze Knorpelkirsche' were stored under hypobaric conditions, 5 kPa and 25 kPa at 2°C. These sweet cherries could be stored for 30 days without a high losses. Sweet cherries of both cvs tasted the best after storage under LPS, worse under CA, and the worst in normal air. Titrate acidity decreased during the storage period, the percent of soluble solids decreased for 15 days after which it increased. Mostly Botrytis cinerea and Monilinia spp. destroyed the sweet cherries during storage. Penicillium spp. affected fruits by less than 1% under kPa, and those subsequently stored for 3 days at 20°C. Hypobaric storage 5 kPa at 2°C seems to be patricularly good for storage of sweet cherries cv. 'Emperor Francis'.

  18. The garden of the self-service store

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino; Esbjerg, Lars

    2006-01-01

    As a result of the increased competition between self-service chains, retail managers to an increasing degree try to strengthen store identity and customer loyalty. Based on a broad range of consumer choice and environmental psychology theories, this article discusses a number of reasons why...... the fruit and vegetable department can be one of the keys to differentiating retail chains and creating positive store image. The article describes the results of two empirical studies (a focus group and a survey), which explore customer-perceived quality dimensions of the fruit and vegetable department...... and the extent to which these dimensions influence customer attitudes towards the fruit and vegetable department and store image in general....

  19. Brand patronage and loyalty patterns in store vs. manufacturer brands

    DEFF Research Database (Denmark)

    Krystallis, Athanasios; Chrysochou, Polymeros

    , while offering good value for money. There is a large body of literature explaining and further exploring factors that influence loyalty towards store brands (e.g. among others Steenkamp and Dekimpe, 1997; Dhar and Hoch, 1997; Ailawadi and Keller, 2004; De Wulf et al, 2005). The objective of the work...... is to investigate the potential existence of differences in the loyalty behaviour between store brands and manufacturer brands, as expressed through certain brand performance and loyalty measures (e.g. market shares, penetration, purchase frequencies, repeat rate, etc.). In order to meet the above......-described objective, panel data from the soft-drinks market in Greece are used, with the premise to investigate brand performance and loyalty of store brands. Observed loyalty measures are benchmarked against predictions from the Dirichlet model (Ehrenberg, Uncles and Goodhardt 2004). The aim of this work is, first...

  20. How to Conduct Store Observations of Tobacco Marketing and Products.

    Science.gov (United States)

    Feld, Ashley L; Johnson, Trent O; Byerly, Katherine W; Ribisl, Kurt M

    2016-02-18

    As tobacco companies continue to heavily market their products at the point of sale, tobacco control groups seek strategies to combat the negative effects of this marketing. Store observations, which have been widely used by researchers and practitioners alike, are an excellent surveillance tool. This article provides a guide for public health practitioners interested in working in the tobacco retail environment by detailing the steps involved in conducting store observations of tobacco marketing and products including 1) obtaining tobacco product retailer lists, 2) creating measures, 3) selecting a mode of data collection, 4) training data collectors, and 5) analyzing data. We also highlight issues that may arise while in the field and provide information on disseminating results of store observations, including the potential policy implications.

  1. The Effect of Music on Store Shopping: Mediating Role of the Time Spent of Customer in Store

    Directory of Open Access Journals (Sweden)

    seyyed hamid khodadad

    2013-09-01

    Full Text Available Competition issue in today’s market is not exclusively limited to manufacturing enterprises. Suppliers and especially big retailers are increasingly facing this challenging problem too. Regarding to the context of Iranian culture, big retailers are against very large number of small groceries that their successfully survival depends on how they operate intelligently. These kinds of retailers in order to attract customers and increase their shopping volume need to utilize new marketing methods to increase the amount of time spent in store and consequently increase the probability of shopping. One of these methods is playing music in store. The purpose of this study is to investigate the effect of music on customer shopping through the time spent by customer in store. The present study is a survey research in terms of method and an applied-developmental research. Rashtianshoppersof Rasht Big Stores are selected as statistical population. Results using path analysis approach reveals that the effect of music on customer shopping through the time spent in store is confirmed. On the other hand, there are numerous differences among customers with various demographic characteristics.

  2. Storing Clocked Programs Inside DNA A Simplifying Framework for Nanocomputing

    CERN Document Server

    Chang, Jessica

    2011-01-01

    In the history of modern computation, large mechanical calculators preceded computers. A person would sit there punching keys according to a procedure and a number would eventually appear. Once calculators became fast enough, it became obvious that the critical path was the punching rather than the calculation itself. That is what made the stored program concept vital to further progress. Once the instructions were stored in the machine, the entire computation could run at the speed of the machine. This book shows how to do the same thing for DNA computing. Rather than asking a robot or a pers

  3. Article of Clothing for Storing and Deploying a Scarf

    Science.gov (United States)

    Romero, Robert (Inventor)

    2015-01-01

    A clothing article surrounds a wearer's upper torso. The article includes connected front portion, a collar. A sleeve is formed in the front portion. A jacket, and coat with an attachable/detachable scarf will be folded and stored in the inter portion of the front side of the collar area with elastic at each end and Velcro onto the inner portion of your collar, therefore eliminating the lost of them by any consumers, and especially children. A sleeve like collar attached to the coat and jacket for storing a scarf and making it easily deployable while in use.

  4. Consumers' price knowledge before, during, and after store visit

    DEFF Research Database (Denmark)

    Jensen, Birger Boutrup

    visit, thus enabling a study of what consumers learn about prices during the store visit, and consequently the relationship between reference prices and episodic price knowledge. The project applies three measures of consumers' price knowledge corresponding to different levels of price information......Many attempts have been made to measure consumers' price knowledge for frequently purchased goods. However, the results have varied considerably and conflict with the results of reference price studies. This is the first study to examine consumers' price knowledge before, during, and after store...... processing, which furthermore allows us to examine whether consumers' price memory is one- or multidimensional....

  5. Stored electromagnetic energy and quality factor of radiating structures

    Science.gov (United States)

    Capek, Miloslav; Jelinek, Lukas; Vandenbosch, Guy A. E.

    2016-04-01

    This paper deals with the old yet unsolved problem of defining and evaluating the stored electromagnetic energy-a quantity essential for calculating the quality factor, which reflects the intrinsic bandwidth of the considered electromagnetic system. A novel paradigm is proposed to determine the stored energy in the time domain leading to the method, which exhibits positive semi-definiteness and coordinate independence, i.e. two key properties actually not met by the contemporary approaches. The proposed technique is compared with an up-to-date frequency domain method that is extensively used in practice. Both concepts are discussed and compared on the basis of examples of varying complexity.

  6. Polarization of a stored beam by spin-filtering

    Energy Technology Data Exchange (ETDEWEB)

    Augustyniak, W. [National Centre for Nuclear Research, 00681 Warsaw (Poland); Barion, L. [Universita di Ferrara and INFN, 44122 Ferrara (Italy); Barsov, S. [St. Petersburg Nuclear Physics Institute, 188350 Gatchina (Russian Federation); Bechstedt, U. [Institut fuer Kernphysik, Forschungszentrum Juelich GmbH, 52425 Juelich (Germany); Juelich Center for Hadron Physics, 52425 Juelich (Germany); Benati, P.; Bertelli, S.; Carassiti, V. [Universita di Ferrara and INFN, 44122 Ferrara (Italy); Chiladze, D. [High Energy Physics Institute, Tbilisi State University, 0186 Tbilisi, Georgia (United States); Ciullo, G.; Contalbrigo, M.; Dalpiaz, P.F. [Universita di Ferrara and INFN, 44122 Ferrara (Italy); Dymov, S. [Physikalische Institute II, Universitaet Erlangen-Nuernberg, 91058 Erlangen (Germany); Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, 141980 Dubna (Russian Federation); Engels, R. [Institut fuer Kernphysik, Forschungszentrum Juelich GmbH, 52425 Juelich (Germany); Juelich Center for Hadron Physics, 52425 Juelich (Germany); Erwen, W. [Juelich Center for Hadron Physics, 52425 Juelich (Germany); Zentralinstitut fuer Elektronik, Forschungszentrum Juelich GmbH, 52425 Juelich (Germany); Fiorini, M. [Universita di Ferrara and INFN, 44122 Ferrara (Italy); and others

    2012-11-15

    The PAX Collaboration has successfully performed a spin-filtering experiment with protons at the COSY-ring. The measurement allowed the determination of the spin-dependent polarizing cross section, that compares well with the theoretical prediction from the nucleon-nucleon potential. The test confirms that spin-filtering can be adopted as a method to polarize a stored beam and that the present interpretation of the mechanism in terms of the proton-proton interaction is correct. The outcome of the experiment is of utmost importance in view of the possible application of the method to polarize a beam of stored antiprotons.

  7. Alpha low-level stored waste systems design study

    Energy Technology Data Exchange (ETDEWEB)

    Feizollahi, F.; Teheranian, B. [Morrison Knudson Corp., San Francisco, CA (United States). Environmental Services Div.; Quapp, W.J. [EG and G Idaho, Inc., Idaho Falls, ID (United States)

    1992-08-01

    The Stored Waste System Design Study (SWSDS), commissioned by the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examines relative life-cycle costs associated with three system concepts for processing the alpha low-level waste (alpha-LLW) stored at the Radioactive Waste Management Complex`s Transuranic Storage Area at the INEL. The three system concepts are incineration/melting; thermal treatment/solidification; and sort, treat, and repackage. The SWSDS identifies system functional and operational requirements and assesses implementability; effectiveness; cost; and demonstration, testing, and evaluation (DT&E) requirements for each of the three concepts.

  8. Alpha low-level stored waste systems design study

    Energy Technology Data Exchange (ETDEWEB)

    Feizollahi, F.; Teheranian, B. (Morrison Knudson Corp., San Francisco, CA (United States). Environmental Services Div.); Quapp, W.J. (EG and G Idaho, Inc., Idaho Falls, ID (United States))

    1992-08-01

    The Stored Waste System Design Study (SWSDS), commissioned by the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examines relative life-cycle costs associated with three system concepts for processing the alpha low-level waste (alpha-LLW) stored at the Radioactive Waste Management Complex's Transuranic Storage Area at the INEL. The three system concepts are incineration/melting; thermal treatment/solidification; and sort, treat, and repackage. The SWSDS identifies system functional and operational requirements and assesses implementability; effectiveness; cost; and demonstration, testing, and evaluation (DT E) requirements for each of the three concepts.

  9. The Use Of A Digital Store To Provide Pulsed Fluoroscopy And Stored Images During Gastro-Intestinal Examinations

    Science.gov (United States)

    Hynes, D. M.; Edmonds, E. W.; Rowlands, J. A.; Pack, W. W.

    1984-08-01

    A 512 X 512 digital store has replaced a video disc as a storage mechanism during pulsed fluoroscopy. This system, storing 1 TV field from a 1023 line signal following each pulse, is much more stable than the analog disc and can also reduce the fluoroscopic dose by 75%. This stability now makes the concept of pulsed fluoroscopy acceptable from the clinical point of view. Furthermore, the stored images on this matrix can resolve to 1.5 line pairs per mm, which produces useful permanent hard copy. This represents a further extension of clinical videofluorography, already developed by the authors. Its implementation for storage of gastro-intestinal examinations will be discussed, with assessment of the relationship of x-ray dose to image quality.

  10. The impact of quality on store loyalty : A contingency approach

    NARCIS (Netherlands)

    Odekerken-Schroder, G; De Wulf, K; Kasper, H; Kleijnen, M; Hoekstra, J; Commandeur, H

    2001-01-01

    This study's prime interest is to assist retail managers in deciding where they are likely to get the greatest response to their expenditures on quality improvement. An empirical test involving 287 consumers reporting on a wide array of stores assesses whether the relationship between three quality

  11. Decomposing the sales promotion bump with store data

    NARCIS (Netherlands)

    van Heerde, H.J.; Leeflang, P.S.H.; Wittink, D.R.

    2004-01-01

    Sales promotions generate substantial short-term sales increases. To determine whether the sales promotion bump is truly beneficial from a managerial perspective, we propose a system of store-level regression models that decomposes the sales promotion bump into three parts: cross-brand effects (seco

  12. 75 FR 37378 - Exemption for Retail Store Operations

    Science.gov (United States)

    2010-06-29

    ..., poultry and poultry products that a retail store can sell to hotels, restaurants, and similar institutions... food, poultry, and poultry products. Sales to Hotels, Restaurants, and Similar Institutions Under these regulations, sales to hotels, restaurants, and similar institutions (other than household...

  13. Online purchase intentions: A multi-channel store image perspective

    NARCIS (Netherlands)

    Verhagen, T.; van Dolen, W.

    2009-01-01

    The advantages of the bricks-and-clicks retail format in the battle for the online customer has been widely discussed but empirical research on it has been limited. We applied a multi-channel store image perspective to assess its influence on online purchase intentions. Drawing on a sample of 630 cu

  14. Inventory of Tank Farm equipment stored or abandoned aboveground

    Energy Technology Data Exchange (ETDEWEB)

    Hines, S.C.; Lakes, M.E.

    1994-10-12

    This document provides an inventory of Tank Farm equipment stored or abandoned aboveground and potentially subject to regulation. This inventory was conducted in part to ensure that Westinghouse Hanford Company (WHC) does not violate dangerous waste laws concerning storage of potentially contaminated equipment/debris that has been in contact with dangerous waste. The report identifies areas inventoried and provides photographs of equipment.

  15. How Store Design Affect the Consumer Evaluation of Fashion Items

    DEFF Research Database (Denmark)

    Münster, Mia Borch; Kristensen, Tore; Gabrielsen, Gorm

    to investigate. Consumers, brand owners and retail designers perceive the environments differently and methods for testing the effects on the specific consumers would be useful. This paper describes an experiment run in a men’s fashion store holding three sub-brands, each displayed in separate rooms, which were...

  16. A column-store meets the point clouds

    NARCIS (Netherlands)

    Martinez-Rubi, O.; Kersten, M.L.; Goncalves, R.; Ivanova, M.

    2014-01-01

    Column stores have become the de-facto standard for most datawarehouse solutions. The regularity and query patterns of LIDAR data are a potential application area well suited for this technology. In this short work in progress paper we report on our experiences in supporting point cloud data using P

  17. Stored energy and annealing behavior of heavily deformed aluminium

    DEFF Research Database (Denmark)

    Kamikawa, Naoya; Huang, Xiaoxu; Kondo, Yuka

    2012-01-01

    followed by 0.5 h annealing at 200-600°C, where the former treatment leads to discontinuous recrystallization and the latter to uniform structural coarsening. This behavior has been analyzed in terms of the relative change during annealing of energy stored as elastic energy in the dislocation structure...

  18. 41 CFR 109-27.5004 - Sub-stores.

    Science.gov (United States)

    2010-07-01

    ...-INVENTORY MANAGEMENT 27.50-Inventory Management Policies, Procedures, and Guidelines § 109-27.5004 Sub... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Sub-stores. 109-27.5004 Section 109-27.5004 Public Contracts and Property Management Federal Property Management...

  19. 46 CFR 194.05-3 - Chemical stores.

    Science.gov (United States)

    2010-10-01

    ... shall be classed, marked and labeled in accordance with 49 CFR part 172: (1) Explosives. (2) Flammable... under paragraph (a) of this section but not specifically listed by name in 49 CFR 172.101 must be... 46 Shipping 7 2010-10-01 2010-10-01 false Chemical stores. 194.05-3 Section 194.05-3...

  20. Monitoring sodium in commercially processed foods from stores and restaurants

    Science.gov (United States)

    Most of the sodium we eat comes from commercially processed foods from stores and restaurants. Sodium reduction in these foods is a key component of several recent public health efforts. Agricultural Research Service (ARS) of USDA, CDC and FDA have launched a collaborative program to monitor sodium ...

  1. Decisive Visual Saliency and Consumers' In-store Decisions

    DEFF Research Database (Denmark)

    Clement, Jesper; Aastrup, Jesper; Forsberg, Signe Charlotte

    2015-01-01

    This paper focuses on consumers' in-store visual tactics and decision-making. It has been argued that many consumers shop by routine or by simple rules and justification techniques when they purchase daily commodities. It has also been argued that they make a majority of decisions in the shop...

  2. An Insight into the Growth of Department Stores in Hangzhou

    Institute of Scientific and Technical Information of China (English)

    XIE Yuan-yuan

    2016-01-01

    This assignment will critically examine the competitive strategies of four selected department stores in Hangzhou and the reasons why the choice of them depends on different customer values. It will also highlight the capabilities that companies used to realize their strategies.

  3. WHEN TO STORE ENERGY IN A STOCHASTIC ENVIRONMENT

    Science.gov (United States)

    Fischer, Barbara; Dieckmann, Ulf; Taborsky, Barbara

    2012-01-01

    The ability to store energy enables organisms to deal with temporarily harsh and uncertain conditions. Empirical studies have demonstrated that organisms adapted to fluctuating energy availability plastically adjust their storage strategies. So far, however, theoretical studies have investigated general storage strategies only in constant or deterministically varying environments. In this study, we analyze how the ability to store energy influences optimal energy allocation to storage, reproduction, and maintenance in environments in which energy availability varies stochastically. We find that allocation to storage is evolutionarily optimal when environmental energy availability is intermediate and energy stores are not yet too full. In environments with low variability and low predictability of energy availability, it is not optimal to store energy. As environments become more variable or more predictable, energy allocation to storage is increasingly favored. By varying environmental variability, environmental predictability, and the cost of survival, we obtain a variety of different optimal life-history strategies, from highly iteroparous to semelparous, which differ significantly in their storage patterns. Our results demonstrate that in a stochastically varying environment simultaneous allocation to reproduction, maintenance, and storage can be optimal, which contrasts with previous findings obtained for deterministic environments. PMID:21108636

  4. Determining host suitability of pecan for stored-product insects

    Science.gov (United States)

    A no-choice test was performed to determine survival and reproductive capacity of stored-product insect pests on pecan, Carya illinoensis (Wangenheim) Koch. Insects used were Indianmeal moth, Plodia interpunctella (Hübner) (Lepidoptera: Pyralidae); sawtoothed grain beetle, Oryzaephilus surinamensis...

  5. Population dynamics of two stored-product pyralid moths.

    Science.gov (United States)

    Seasonal trends and short-term fluctuations in abundance of Plodia interpunctella (Hübner) and Cadra cautella (Walker) infesting corn stored on two South Carolina farms were studied during three storage seasons. Coils of corrugated paper placed on the grain surface were used to trap mature larvae ...

  6. User-Assisted Store Recycling for Dynamic Task Graph Schedulers

    Energy Technology Data Exchange (ETDEWEB)

    Kurt, Mehmet Can [Quantcast Corporation, San Francisco, CA; Krishnamoorthy, Sriram [Pacific Northwest National Laboratory, Richland, WA; Agrawal, Gagan [The Ohio State University, Neil Avenue Columbus, OH; Ren, Bin [The College of William and Mary, Williamsburg, VA

    2016-12-28

    The emergence of the multi-core era has led to increased interest in designing effective yet practical parallel programming models. Models based on task graphs that operate on single-assignment data are attractive in several ways: they can support dynamic applications and precisely represent the available concurrency. However, they also require nuanced algorithms for scheduling and memory management for efficient execution. In this paper, we consider memory-efficient dynamic scheduling of task graphs. Specifically, we present a novel approach for dynamically recycling the memory locations assigned to data items as they are produced by tasks. We develop algorithms to identify memory-efficient store recycling functions by systematically evaluating the validity of a set of (user-provided or automatically generated) alternatives. Because recycling function can be input data-dependent, we have also developed support for continued correct execution of a task graph in the presence of a potentially incorrect store recycling function. Experimental evaluation demonstrates that our approach to automatic store recycling incurs little to no overheads, achieves memory usage comparable to the best manually derived solutions, often produces recycling functions valid across problem sizes and input parameters, and efficiently recovers from an incorrect choice of store recycling functions.

  7. Quality of whey powders stored under adverse conditions

    Science.gov (United States)

    Whey protein concentrate powder (WPC) is exported by the U.S. and is included in emergency aid foods, but the bags sent overseas are usually stored without refrigeration and under elevated temperature and relative humidity (RH). The shelf life of WPC under adverse conditions must be known to preven...

  8. Kreative ledere - store ideer gennem 30 år

    DEFF Research Database (Denmark)

    Hermansen, Judy

    2010-01-01

    Kreativitet påvirkes ligesom alt andet af den samfundsmæssige udvikling, men præcis hvordan ved vi ikke så meget om. Det er dog en udbredt opfattelse blandt kreative ledere selv, at reklamekreativiteten er faldet. Denne undersøgelse bygger på interview med kreative ledere fra store og mellemstore...

  9. Availability of Vending Machines and School Stores in California Schools

    Science.gov (United States)

    Cisse-Egbuonye, Nafissatou; Liles, Sandy; Schmitz, Katharine E.; Kassem, Nada; Irvin, Veronica L.; Hovell, Melbourne F.

    2016-01-01

    Background: This study examined the availability of foods sold in vending machines and school stores in United States public and private schools, and associations of availability with students' food purchases and consumption. Methods: Descriptive analyses, chi-square tests, and Spearman product-moment correlations were conducted on data collected…

  10. Det lille land før den store krig

    DEFF Research Database (Denmark)

    Clemmesen, Michael Hesselholt

    Krige i Nordafrika og på Balkan. Den Store Krig truede. Den tyske marine brugte danske farvande som sine egne, men den unge, aggressive britiske marineminister Churchill ville nu presse sin flåde ind i Kattegat, uden hensyn til dansk og svensk neutralitet, i risikable operationer, der kunne udløse...

  11. BRAND PLACEMENT AND CONSUMER CHOICE: AN IN-STORE EXPERIMENT

    Science.gov (United States)

    Sigurdsson, Valdimar; Saevarsson, Hugi; Foxall, Gordon

    2009-01-01

    An in-store experiment was performed to investigate the effects of shelf placement (high, middle, low) on consumers' purchases of potato chips. Placement of potato chips on the middle shelf was associated with the highest percentage of purchases. The results confirm the importance of item placement as a factor in consumers' buying behavior. PMID:20190939

  12. Storing and Querying Probabilistic XML Using a Probabilistic Relational DBMS

    NARCIS (Netherlands)

    Hollander, E.S.; Keulen, van M.

    2010-01-01

    This work explores the feasibility of storing and querying probabilistic XML in a probabilistic relational database. Our approach is to adapt known techniques for mapping XML to relational data such that the possible worlds are preserved. We show that this approach can work for any XML-to-relational

  13. Storing the Electric Energy Produced by an AC Generator

    Science.gov (United States)

    Carvalho, P. Simeao; Lima, Ana Paula; Carvalho, Pedro Simeao

    2010-01-01

    Producing energy from renewable energy sources is nowadays a priority in our society. In many cases this energy comes as electric energy, and when we think about electric energy generators, one major issue is how we can store that energy. In this paper we discuss how this can be done and give some ideas for applications that can serve as a…

  14. 18 CFR 367.1630 - Account 163, Stores expense undistributed.

    Science.gov (United States)

    2010-04-01

    ... GAS ACT Balance Sheet Chart of Accounts Current and Accrued Assets § 367.1630 Account 163, Stores... expense undistributed. 367.1630 Section 367.1630 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE PUBLIC UTILITY HOLDING COMPANY ACT OF...

  15. A MODULAR STORE FOR DRUMS OF RADIOACTIVE WASTE

    Energy Technology Data Exchange (ETDEWEB)

    Sims, J.; Holden, G.

    2003-02-27

    Currently, the United Kingdom has no facility for the disposal of any waste above the low level category, indicating that all intermediate and high level waste, apart from spent fuel, has to be stored on the site of origin. To meet this storage requirement, nuclear sites are resorting to converting existing buildings or contemplating the construction of dedicated facilities, resulting in considerable cost implications. These financing aspects not only concern the construction strategy but also impinge on the ultimate decommissioning costs associated with each particular nuclear site. This paper reports on an investigation to apply the commercially available interlocking hollow block system to the design of a store for drums of radioactive waste. This block system can be quickly, and cost effectively, erected and filled with a choice of dense material. Later, the store can be dismantled with a minimum of disposable radioactive waste and the complete facility re - erected at another location if required, considerably reducing both capital construction and decommissioning costs. The investigation also encompassed a detailed review of the equipment required to place the drums of waste into the store, resulting in a scheme for a remotely operated vehicle that did not rely on umbilical control cables. The drum handler design included for 100% redundancy of all functions, meaning that whichever component failed, the handler was always recoverable to effect the necessary repair. The ultimate aim of the waste drum store review was to produce a facility that was as safe as a conventionally constructed unit, but at a lower overall building and decommissioning cost.

  16. Presenting a Framework for Ranking Identification System in the Chain Store: Real Case Study of the Iran SHAHRVAND Department Store

    Directory of Open Access Journals (Sweden)

    N. Pilevari

    2014-02-01

    Full Text Available The purpose of this research is to specify and rank the appropriate automatic identifying goods system for a real case of a department store (Shahrvand department store. The ideas of the experts about the most appropriate identifying goods system in the department store are evaluated and collected by the brainstorming method, the three types of identification system which are specified by the brainstorming method are: RFID (Radio Frequency IDentification, Barcode and OCR (Optical Character Recognition. In order to ranking the achieved automatic identification systems and helping the management of the department store for decision making, the promethee (Preference Ranking Organization Method for Enrichment Evaluations method is selected which has the most conformity with this research between the all MCDM (Multi Criteria Decision Making method. Therefore, by consideration of two approaches: “efficiency of identification systems” and “convenience of customer purchase” eight criteria are extracted for ranking the identification system. Finally, the RFID system is preferred to other automatic identifying good systems by the used method in the research.

  17. Evaluating Internal and External Factors of Chain Store for Improvement in Iran: A Case Study (Etka Chain Stores

    Directory of Open Access Journals (Sweden)

    Mohammad Aghaei

    2013-08-01

    Full Text Available The purpose of this study is to extract main indicators for review the internal and external dimensions of Etka chain stores and after the studying the organizational documentation and with using of the customer reviews, was determined the position of Etka chain stores in attractiveness and capabilities matrix. For any organization in any level, it is important to determine its position compared to competitors in terms of attractiveness and capabilities. Considering now that the "Etka chain stores" are the largest supplier of goods and services in Iran and in order to its mission tries to improve the processes of supply, storage, distribution, sales and after sales services company with an economic approach. According to peripheral changes in different dimensions of economic, political, social and also with the emergence fundamental paradigm in business such as service businesses, penetration of IT in business like E-commerce, the answer to this question is important “Where is the position of Etka chain stores in this industry?”. The data collection method is using the questionnaires. Finally the customer reviews have been analyzed.

  18. The Moderating Influence of Supermarket Satisfaction on Out-of-stock Store Switching Behavior

    DEFF Research Database (Denmark)

    Hansen, Torben; Beckmann, Suzanne C.; Solgaard, Hans Stubbe

    2015-01-01

    Consumer store switching behaviour – going to another store to buy an item that is out-of-stock – is often considered to be associated with high brand loyalty in combination with low store loyalty, making a study of the causes for such behaviour highly important to both store and brand managers...

  19. The Moderating Influence of Supermarket Satisfaction on Out-of-Stock Store Switching Behaviour

    DEFF Research Database (Denmark)

    Hansen, Torben; Beckmann, Suzanne C.; Solgaard, Hans Stubbe

    Consumer store switching behaviour – going to another store to buy an item that is out-of-stock is often considered to be associated with high brand loyalty in combination with low store loyalty, making a study of the causes for such behaviour highly important to both store and brand managers...

  20. Consumers rule: how consumer reviews influence perceived trustworthiness of online stores

    NARCIS (Netherlands)

    Utz, S.; Kerkhof, P.; van den Bos, J.

    2012-01-01

    Two studies examined the impact of online store reviews on consumer trust in online stores. Based on the warranting principle, it was proposed that consumer reviews are a more important cue for judging the trustworthiness of an online store than the overall reputation of the store (Experiment 1) or

  1. Consumers rule: How consumer reviews influence perceived trustworthiness of online stores

    NARCIS (Netherlands)

    Utz, S.; Kerkhof, P.; Van den Bos, J.

    2012-01-01

    Two studies examined the impact of online store reviews on consumer trust in online stores. Based on the warranting principle, it was proposed that consumer reviews are a more important cue for judging the trustworthiness of an online store than the overall reputation of the store (Experiment 1) or

  2. Wind turbine tower for storing hydrogen and energy

    Science.gov (United States)

    Fingersh, Lee Jay

    2008-12-30

    A wind turbine tower assembly for storing compressed gas such as hydrogen. The tower assembly includes a wind turbine having a rotor, a generator driven by the rotor, and a nacelle housing the generator. The tower assembly includes a foundation and a tubular tower with one end mounted to the foundation and another end attached to the nacelle. The tower includes an in-tower storage configured for storing a pressurized gas and defined at least in part by inner surfaces of the tower wall. In one embodiment, the tower wall is steel and has a circular cross section. The in-tower storage may be defined by first and second end caps welded to the inner surface of the tower wall or by an end cap near the top of the tower and by a sealing element attached to the tower wall adjacent the foundation, with the sealing element abutting the foundation.

  3. AN INVESTIGATION ON THE CUSTOMER RELATIONSHIP MANAGEMENT IN FURNITURE STORES

    Directory of Open Access Journals (Sweden)

    İlker Akyüz

    2004-11-01

    Full Text Available The most valuable thing for corporations is customers in today’s competitive environment. The evaluation obtained with suitable methodology is important vitally in the success of customer relationship management systems applied for the continuous customer satisfaction and devotion. Continuous customer satisfaction, development of communication skills with customers, caring with customers’ desires and compliments before and after sale just in sale time, development of the quality of services being offered to the customers is dependent on the determining customer problems closely and giving customer focused services. In this study, it was tried to reveal the customer relationship management, communication with customer, customer focused sale offered before, after and just in sale time in some furniture stores located in Trabzon. It was found that the furniture stores in Trabzon have been generally trying to give customer focused sale services

  4. Re-designing Retail Stores with Mobile and Wireless Technologies

    Directory of Open Access Journals (Sweden)

    Riccardo Mangiaracina

    2012-07-01

    Full Text Available Mobile and wireless (M&W technologies have great potential to improve process efficiency and effectiveness within retail stores, but their application is still very limited. One of the main reasons explaining this situation is considered to be the lack of confidence in the actual benefits and, therefore, in the return on investment. As a matter of facts, activities in this context are characterised by great variety and non‐standardised execution and as such the assessment of the costs and benefits of M&W solutions is more difficult than for the upstream tiers of the fast moving consumer goods supply chain (e.g., distribution centres. This paper attempts to provide a contribution for researchers and practitioners by presenting an analytical model to assess the profitability related to investments in multiple M&W solutions for retail stores, thus supporting the decision‐ making process.

  5. Controlled processing of signal stored in metamaterial with tripod structure

    CERN Document Server

    Zielińska-Raczyńska, S

    2016-01-01

    In the present paper we have discussed in detail electromagnetically induced transparency and signal storing in the case of one signal pulses propagating in a classical electric medium resembling this of four-level atoms in the tripod configuration. Our theoretical results confirm recently observed dependence of transparency windows position on coupling parameters. In the process of storing the pulse energy is confined inside the metamaterial as electric charge oscillations and after required time it is possible to switch the control fields on again and to release the trapped signal. By manipulating the driving fields one can thus control the parameters of the released signal and even to divide it on demand into arbitrary parts.

  6. Using Defects in Materials to Store Energy: a Theoretical Study

    Science.gov (United States)

    Lu, I.-Te; Bernardi, Marco

    We study the energy stored by defects in materials using density functional theory (DFT) calculations. Leveraging experimental data to estimate the energy density of defects, expressed as the defect formation energy per unit volume (units of MJ/L) or weight (units of MJ/kg), we identify candidates for high energy density storage, including tungsten, diamond, graphite, silicon, and graphene. DFT calculations are applied to these materials to study the formation energy of vacancies, interstitials, and Frenkel pairs. Our results indicate that the energy density stored by defects in these materials, with experimentally accessible non-equilibrium defect concentrations, can be higher than that of common energy storage technologies such as lithium batteries and supercapacitors. We discuss storage of solar energy and electrical energy (through ion bombardment) using defects.

  7. Reproducibility of Circulating MicroRNAs in Stored Plasma Samples.

    Directory of Open Access Journals (Sweden)

    Monica L Bertoia

    Full Text Available Most studies of microRNA (miRNA and disease have examined tissue-specific expression in limited numbers of samples. The presence of circulating miRNAs in plasma samples provides the opportunity to examine prospective associations between miRNA expression and disease in initially healthy individuals. However, little data exist on the reproducibility of miRNAs in stored plasma.We used Real-Time PCR to measure 61 pre-selected microRNA candidates in stored plasma. Coefficients of variation (CVs were used to assess inter-assay reliability (n = 15 and within-person stability over one year (n = 80. Intraclass correlation coefficients (ICCs and polychoric correlation coefficients were used to assess within-person stability and delayed processing reproducibility (whole blood stored at 4°C for 0, 24 and 48 hours; n = 12 samples.Of 61 selected miRNAs, 23 were detected in at least 50% of samples and had average CVs below 20% for inter-assay reproducibility and 31 for delayed processing reproducibility. Ten miRNAs were detected in at least 50% of samples, had average CVs below 20% and had ICCs above 0.4 for within-person stability over 1-2 years, six of which satisfied criteria for both interassay reproducibility and short-term within-person stability (miR-17-5p, -191-5p, -26a-5p, -27b-3p, -320a, and -375 and two all three types of reproducibility (miR-27b-3p and -26a-5p. However, many miRNAs with acceptable average CVs had high maximum CVs, most had low expression levels, and several had low ICCs with delayed processing.About a tenth of miRNAs plausibly related to chronic disease were reliably detected in stored samples of healthy adults.

  8. Mining the Change of the Quality of Stored Grain

    Institute of Scientific and Technical Information of China (English)

    SHANG Zhi-gen; LOU Wei; ZHOU Wei-min

    2006-01-01

    The quality of grain changes continually during its storage,including the change of its physical characteristics and physiological characteristics. This paper presents an approach to predict the change of the quality of stored grain with data mining technology. Logistic Regression, Decision Tree and Multilayer Perceptron are applied to predict the change of the grains' quality control index and to obtain the grains' quality change probability. The grain sampling with higher probability can be processed earlier.

  9. Histological effects of calcium chloride in stored apples

    Science.gov (United States)

    Mature apples, Malus domestica Borkh., cv. 'Golden Delicious' were immersed for 2 min in 0, 0.14, 0.27, or 0.41 mol L-1 (0, 2%, 4%, or 6%, respectively) aqueous solutions (w/v) of CaCl2 at 0 or 68.95 Kpa, and stored at 0°C. Histological samples of peel/cortex were taken at harvest and at four month...

  10. Coset decomposition method for storing and decoding fingerprint data

    OpenAIRE

    Mohamed Sayed

    2014-01-01

    Biometrics such as fingerprints, irises, faces, voice, gait and hands are often used for access control, authentication and encryption instead of PIN and passwords. In this paper a syndrome decoding technique is proposed to provide a secure means of storing and matching various biometrics data. We apply an algebraic coding technique called coset decomposition to the model of fingerprint biometrics. The algorithm which reveals the matching between registered and probe fingerprints is modeled a...

  11. Sensory profile of 'Douradao' peaches cold stored under controlled atmosphere

    OpenAIRE

    de Santana, LRR; Benedetti, BC; Sigrist, JMM

    2011-01-01

    The sensory quality of 'Douradao' peaches cold stored in three different conditions of controlled atmosphere (CA1, CA2, CA3 and Control) was studied. After 14, 21 and 28 days of cold storage, samples were withdrawn from CA and kept for 4 days in ambient air for ripening. The sensory profile of the peaches and the descriptive terminology were developed by methodology based on the Quantitative Descriptive Analysis (QDA). The panelists consensually defined the sensory descriptors, their respecti...

  12. Pathogen-Reduced, Platelet Additive Solution, Extended Stored Platelets (PREPS)

    Science.gov (United States)

    2015-10-01

    platelets are important to decrease the need for frequent transfusions. Thus, the standard practice has been to store all platelets at 22°C...Resting heart rate : 40 to 100 beats per minute • Subjects must be ≥ 18 years old, of either sex • Subjects must be able to read, understand and sign...1-0441 Page 24 • Currently pregnant or nursing as assessed during interview. A urine pregnancy test prior to radioisotope infusion is required for

  13. Storing and structuring big data with businessintelligence in mind

    OpenAIRE

    Andersson, Fredrik

    2015-01-01

    Sectra has a customer database with approximately 1600 customers across the world. In this system there exists not only medical information but alsoinformation about the environment which the system runs in, usage  pattern and much more. This report is about storing data received from log les into a suitable database. Sectra wants to be able to analyze this information so that they can make strategic decisions and get a better understanding of their customers' needs. The tested databases are ...

  14. Investigations on stratification devices for hot water stores

    DEFF Research Database (Denmark)

    Andersen, Elsa; Furbo, Simon; Hampel, Matthias;

    2008-01-01

    The significance of the thermal stratification for the energy efficiency of small solar-thermal hot water heat stores is pointed out. Exemplary the thermal stratification build-up with devices already marketed as well as with devices still in development has been investigated experimentally...... and theoretically, taking into account different realistic operation conditions. The methods (selective temperature measurement, non-invasive field measuring methods PIV and LIF, Computational Fluid Dynamics (CFD)) suitable for the experimental and theoretical analysis of thermal stratification devices...

  15. Customer service of convenience stores / by K. Kleynhans

    OpenAIRE

    Kleynhans, Karin Belinda Margerete

    2008-01-01

    This study researches the topic customer service of convenience sores. Two objectives are set, namely to measure the customer service levels of convenience stores, and then to determine if any differences exist between customer perceptions and customer expectations. The literature review covers two models of service quality, namely the Kano model and the SERVQUAL model. Both the Kano model and the SERVQUAL model are client service models that currently exist in practice. The Kano model pro...

  16. Enticing consumers to enter fashion stores : a sensory marketing perspective

    OpenAIRE

    Abazi, Jeton; Sohani, Armin

    2016-01-01

    During the past years, there has been a re-emergence of sensory marketing in the paradigm of marketing. However, there is a lack of empirical studies done on the subject. Furthermore, the previous literature has focused on whether senses affects, rather than how they affect. Therefore, the purpose of this thesis is to study how sensory stimuli affects the consumers’ choice of entering physical fashion stores. This thesis is based on sensory marketing, consumer behaviour, and retail marketing...

  17. Communities Putting Prevention to Work: The Healthy Corner Store Initiative

    Centers for Disease Control (CDC) Podcasts

    2013-07-18

    This podcast is an interview with Dr. Stephanie Jilcott Pitts, Associate Professor in the Department of Public Health at East Carolina University. Dr. Pitts answers questions about her study involving a healthy corner store initiative in North Carolina.  Created: 7/18/2013 by Preventing Chronic Disease (PCD), National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 7/18/2013.

  18. Joint Maintenance Policies for a Stored System with Two Units

    Institute of Scientific and Technical Information of China (English)

    XIE Jun; WANG Hong-wei

    2009-01-01

    Failure of a stored system can only be detected after inspection and its reliability can be resumed by replacement of failed components. A maintenance policy of combining periodic inspection and preventive replacement is proposed to improve its availability. To coordinate component replacement and spare provision, an ordering policy of (0,1) is considered jointly. Thus, the joint maintenance policy contains inspection, replacement and spare provision. A programming model based on the joint maintenance policy is established, whose objective function is average expected cost, containing maintenance cost and inventory cost, and the constraint is system availability. Applying renewal theorem, the performance indexes are deduced under the condition that the stored system obeys the common life distribution. Numerical examples are given for a stored system with two different units, where unit 1 probability degrades with time and unit 2 probability degrades at each test. The effect of reliability parameters on the policies is discussed. The results indicate that the joint policy is very close to the independent policy.

  19. Estimation of stored energy in deformed metals from EBSD sets

    Institute of Scientific and Technical Information of China (English)

    YU Tianbo; Andrew GODFREY

    2008-01-01

    A number of methods for estimating the stored energy of deformation from EBSD data have been examined.The methods are illustrated here using samples of AA1100 deformed to strains of εvM=2.4 and εvM=4.0 using the accumulative roll bonding process.A qualitative method,based on pattern contrast,reveals some aspects of local differences in stored energy in the deformed samples.Quantitative methods where the stored energy is estimated through the use of the Read-Shockley equation have also been examined.A special mean misorientation angle is developed to take account of nonlinearity of the Read-Shockley equation.Two approaches have been considered.One is based on subgrain reconstruction and the other is based on misorientation angles taken directly from an orientation map.Calculations show that the subgrain method is particularly sensitive to orientation noise in the data and care must be taken when using this method.

  20. JBA COSMETICS LTD.: MAINTAIN OR CLOSE THE WEST STORE?

    Directory of Open Access Journals (Sweden)

    Moacir Sancovschi

    2014-05-01

    Full Text Available The objective in this case is to illustrate the use of relevant cost concepts and techniques for the analysis of long-term policy decisions. It was conceived for discussion in the subjects Management Accounting or Cost Accounting in undergraduate and graduate lato sensu programs in Accountancy, Business Administration and Production Engineering. JBA Cosmetics Ltd. Is a small-sized company specialized in the sale of female cosmetics. In 2010, it had three stores, North, South and West. The latter had been presenting unsatisfactory results, despite the growth in the cosmetics sector. Uncomfortable with this situation, the partners had to decide on whether to close the loss-making store or not. Therefore, they had to compare the store’s revenues and attributable costs – variable costs, divisible fixed costs and indivisible traceable costs. The determination of the attributable costs, as the students will be able to perceive when answering the proposed questions, involves a considerable degree of subjectivity. These questions also suggest qualitative factors that should not be ignored in this type of decision. It can be argued that the uncertainties involved in decisions, like the closure of a store, are better conceived through case analysis than through problem solving.

  1. SIMULATIONS OF THE AGS MMPS STORING ENERGY IN CAPACITOR BANKS

    Energy Technology Data Exchange (ETDEWEB)

    MARNERIS,I.; BADEA, V.S.; BONATI, R.; ROSER, T.; SANDBERG, J.

    2007-06-25

    The Brookhaven AGS Main Magnet Power Supply (MMPS) is a thyristor control supply rated at 5500 Amps, +/-9000 Volts. The peak magnet power is 50 MWatts. The power supply is fed from a motor/generator manufactured by Siemens. The generator is 3 phase 7500 Volts rated at 50 MVA. The peak power requirements come from the stored energy in the rotor of the motor/generator. The motor generator is about 45 years old, made by Siemens and it is not clear if companies will be manufacturing similar machines in the future. We are therefore investigating different ways of storing energy for future AGS MMPS operations. This paper will present simulations of a power supply where energy is stored in capacitor banks. Two dc to dc converters will be presented along with the control system of the power section. The switching elements will be IGCT's made by ABB. The simulation program used is called PSIM version 6.1. The average power from the local power authority into the power supply will be kept constant during the pulsing of the magnets at +/-50 MW. The reactive power will also be kept constant below 1.5 MVAR. Waveforms will be presented.

  2. Model of Improving Customer Loyalty in Electronic Stores

    Directory of Open Access Journals (Sweden)

    Ali Attafar

    2011-12-01

    Today, due to the growth and diversity of e-commerce technologies, the number of virtual stores is exponentially increasing and this has created new challenges in business. Therefore, improving customer loyalty is critically important for sustaining success of electronic stores. In this regard, an attempt has been made to propose an appropriate model for improving loyalty of customers in electronic stores. The study population includes faculty and students of Yazd University who have had experience of buying books from online bookstores. Due to non-normal distribution of data, nonparametric methods (sign test, Mann-Whitney, Friedman and Kruskal-Wallis have been used for data analysis. Findings imply that 21 components have been extracted in three general categories, i.e. customer service, design and trust influence e-loyalty, which explain totally 70% of the structure of factors influencing e-loyalty in online bookstores. Findings indicate that from the viewpoint of faculty and students of Yazd University, indicators related to "trust" have the highest influence on improving e-loyalty.

  3. Model of Improving Customer Loyalty in Electronic Stores

    Directory of Open Access Journals (Sweden)

    Ali Atafar

    2011-01-01

    Full Text Available Today, due to the growth and diversity of e-commerce technologies, the number of virtual stores is exponentially increasing and this has created new challenges in business. Therefore, improving customer loyalty is critically important for sustaining success of electronic stores. In this regard, an attempt has been made to propose an appropriate model for improving loyalty of customers in electronic stores. The study population includes faculty and students of Yazd University who have had experience of buying books from online bookstores. Due to non-normal distribution of data, nonparametric methods (sign test, Mann-Whitney, Friedman and Kruskal-Wallis have been used for data analysis. Findings imply that 21 components have been extracted in three general categories, i.e. customer service, design and trust influence e-loyalty, which explain totally 70% of the structure of factors influencing e-loyalty in online bookstores. Findings indicate that from the viewpoint of faculty and students of Yazd University, indicators related to "trust" have the highest influence on improving e-loyalty.

  4. Stabilization mechanisms for information stored in magnetic nanowire arrays

    Science.gov (United States)

    Cisternas, Eduardo; Faúndez, Julián; Vogel, Eugenio E.

    2017-03-01

    The durability of the stored information in magnetic systems is one important feature in firmware applications such as security codes, magnetic keys and other similar products. In the present paper we discuss two different ways of preserving patterns in the set of magnetic wires trapped in the porous membranes used to produce them. One of the techniques is the inscription of an opposite magnetic band of about 1/3 the width of the stored pattern which minimizes the repulsive energy among the ferromagnetic cylinders still leaving a potent magnetic signal to be read. The other technique makes use of segmented nanowires which present a competition of repulsive energy of segments within the same layer while the interaction is attractive with the closer segments of the other layer; such a competition can lead to stabilization if the geometrical parameters are properly controlled. The first technique is cheaper and faster to implement, while the second technique needs a more complete fabrication process but can lead to more durable stored information.

  5. Research of an Online Service System for Beverages Chain Stores

    Directory of Open Access Journals (Sweden)

    Chih-Yao Lo

    2011-01-01

    Full Text Available Problem statement: In the highly competitive market, the availability of consumer support is the key to market-based beverage stores. Consumer demands for quality service so the industry must be more active to improve the quality of management to ensure that beverage market position. In order to allow market competition to be improved for the beverage store. Approach: The system builds an information network using web-based system provides operators and consumers a direct interaction. Enter the phone number provided by the consumer via the Send Message System (SMS verification code to obtain the online ordering drinks service. Using the Internet Information Technology makes the real-time order so that consumers can enjoy easy ordering and comfortable environment. Results: Using this internet beverage ordering system the online consumers can enjoy the choice of ordering drinks. This internet beverage ordering system would also build some databases to support, such as beverage type database, order database, outgoing regional database, these databases information will enable the industry to conduct drinks promotion strategy adjustments. Conclusion: This study uses cell phone number to enable consumers to obtain authentication codes via SMS. Necessary to convert the current beverage stores different marketing approach, through the information network and Web page interactivity, so that consumers would feel very interesting and fresh.

  6. Inspection of collapse cause of Sampoong Department Store.

    Science.gov (United States)

    Park, Tae Won

    2012-04-10

    On June 29, 1995, the Sampoong Department Store in Seoul, South Korea, completely collapsed. It was a five story reinforced concrete (RC) building with underground 4 floors and was built using a technique called "flat slab construction". The collapse is the largest peacetime disaster in South Korean history - 502 people died, 6 missing, and 937 sustained injuries. The Sampoong Department Store was completed in late 1989, and it opened to the public on July 7, 1990, attracting an estimated 40,000 people per day during the building's 5 years in service. After the collapse, intense investigation was conducted to find out the direct causes of the collapse through (1) survey on the present collapse situation and ground condition, (2) strength test of the concrete and steel collected at the site, (3) design documents and construction/management reports, and (4) structural analysis. The investigation revealed that the Sampoong Department Store collapsed because so many direct and indirect causes such as flaws in design phase and mistakes in construction and management process were overlapped.

  7. Collecting and Storing Data Flow Monitoring in Elasticsearch

    CERN Document Server

    Hashim, Fatin Hazwani

    2014-01-01

    A very large amount of data is produced from the online data flow monitoring for the CMS data acquisition system. However, there are only a small portion of data is stored permanently in the relational database. This is because of the high cost needed while relying on the dedicated infrastructure as well as the issues in its performance itself. A new approach needs to be found in order to confront such a big volume of data known as “Big Data”. The Big Data [1] is the term given to the very large and complex data sets that cannot be handled by the traditional data processing application [2] in terms of capturing, storing, managing, and analyzing. The sheer size of the data [3] in CMS data acquisition system is one of the major challenges, and is the one of the most easily recognized. New technology need to be used as the alternative of the traditional databases initial evaluation to handle this problem as more data need to be stored permanently and can be easily retrieved. This report consists of the intro...

  8. Operation of the Australian Store.Synchrotron for macromolecular crystallography

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Grischa R. [Monash University, Clayton, Victoria 3800 (Australia); Aragão, David; Mudie, Nathan J.; Caradoc-Davies, Tom T. [Australian Synchrotron, 800 Blackburn Road, Clayton, Victoria 3168 (Australia); McGowan, Sheena; Bertling, Philip J.; Groenewegen, David; Quenette, Stevan M. [Monash University, Clayton, Victoria 3800 (Australia); Bond, Charles S. [The University of Western Australia, 35 Stirling Highway, Crawley 6009, Western Australia (Australia); Buckle, Ashley M. [Monash University, Clayton, Victoria 3800 (Australia); Androulakis, Steve, E-mail: steve.androulakis@monash.edu [Monash Bioinformatics Platform, Monash University, Clayton, Victoria 3800 (Australia)

    2014-10-01

    The Store.Synchrotron service, a fully functional, cloud computing-based solution to raw X-ray data archiving and dissemination at the Australian Synchrotron, is described. The Store.Synchrotron service, a fully functional, cloud computing-based solution to raw X-ray data archiving and dissemination at the Australian Synchrotron, is described. The service automatically receives and archives raw diffraction data, related metadata and preliminary results of automated data-processing workflows. Data are able to be shared with collaborators and opened to the public. In the nine months since its deployment in August 2013, the service has handled over 22.4 TB of raw data (∼1.7 million diffraction images). Several real examples from the Australian crystallographic community are described that illustrate the advantages of the approach, which include real-time online data access and fully redundant, secure storage. Discoveries in biological sciences increasingly require multidisciplinary approaches. With this in mind, Store.Synchrotron has been developed as a component within a greater service that can combine data from other instruments at the Australian Synchrotron, as well as instruments at the Australian neutron source ANSTO. It is therefore envisaged that this will serve as a model implementation of raw data archiving and dissemination within the structural biology research community.

  9. Phthalates and polybrominated diphenyl ethers in retail stores

    Science.gov (United States)

    Xu, Ying; Liang, Yirui; Urquidi, Jorge R.; Siegel, Jeffrey A.

    2014-04-01

    Retail stores contain a wide range of products that can emit a variety of indoor pollutants. Among these chemicals, phthalate esters and polybrominated diphenyl ethers (PBDEs) are two important categories, because they are extensively used as additives in consumer products and associated with serious health concerns. This study measured six phthalate and 14 PBDE compounds inside of 12 retail stores in Texas and Pennsylvania, U.S. Phthalates and PBDEs were widely found in the retail environment, indicating that they are ubiquitous indoor air pollutants. DEP, DnBP, and DEHP were the most abundant phthalates, with DnBP showing the highest concentration (0.23 ± 0.36 μg m-3). PBDEs were dominated by BDE-28, -99, and -209, having concentrations as high as 0.85 ± 1.99 ng m-3 (BDE-99). The levels of phthalates and PBDEs measured in this study are comparable to concentrations found in previous investigations of residential buildings, with phthalates showing lower concentrations and PBDEs exhibiting higher concentrations in retail stores. The potential co-occurrence of phthalates was not as strong as that of PBDEs, suggesting that phthalates might have more diverse sources. Whole building emission rates were calculated and showed similar patterns of variations as indoor air concentrations, suggestion the diversity of indoor sources of phthalates and PBDEs in retail environments.

  10. Formative Evaluation for a Healthy Corner Store Initiative in Pitt County, North Carolina: Engaging Stakeholders for a Healthy Corner Store Initiative, Part 2

    Directory of Open Access Journals (Sweden)

    Katherine K. Lawton, MPH

    2013-07-01

    Full Text Available Introduction We examined the feasibility of increasing access to healthful food in corner stores to inform a Communities Putting Prevention to Work (CPPW initiative by engaging stakeholders (corner store owners and customers in a formative evaluation. Methods Qualitative interviews were conducted with corner store owners and managers (n = 11. Customer intercept surveys (n = 179 were also conducted with customers of 9 stores. Corner stores were located in rural food deserts (municipalities without a chain supermarket and in low-income, urban municipalities in eastern North Carolina. Interviews were transcribed verbatim and double-coded. Qualitative themes related to feasibility of increasing access to healthful foods were extracted. Shopping patterns of rural and urban customers were compared by using t tests. Results Corner store owners were willing to stock more healthful foods, but they perceived that customer demand for these foods was low. Rural customers reported more frequently shopping at corner stores than urban customers and more frequently stated that the reason they do not eat more fruits and vegetables is that the stores in which they shop do not sell them. Most customers reported they would be very or somewhat likely to purchase fresh produce at a corner store. Conclusion Corner stores may be an important source of food for rural and low-income residents and thus a good place in which to intervene. The results of this formative evaluation were used to plan and evaluate a CPPW healthy corner store initiative.

  11. Polux and K-store - Trendsetting technologies for wooden poles; Polux und K-Store - Zukunftstraechtige Technologien fuer Holzmasten

    Energy Technology Data Exchange (ETDEWEB)

    Sandoz, J.L.; Kratzeisen, S. [ETH Lausanne (Switzerland)

    1999-04-06

    The use of electric lines on wooden poles poses two problems for companies: To guarantly the utmost safty of their employees, and to minimise the maintenance costs. New devices developed by the Swiss Federal Institute of Technology of Lausanne respond to these problems in a reliable way. Polux is a portable device, which specifies the security diagnosis and the probable longevity of wooden poles by a diode. The K-store software analyses the data and optimises the maintenance costs. (orig.) [Deutsch] Bei der Nutzung elektrischer Leitungen auf Holzmasten stellt sich Unternehmern ein doppeltes Problem: Ihrem Personal groesstmoegliche Sicherheit zu garantieren und die Unterhaltskosten niedrig zu halten. An der Eidgenoessischen Technischen Hochschule in Lausanne entwickelte Technologien fuer Holzmasten begegnen diesen Risikofaktoren auf zuverlaessige Weise. Polux ist ein tragbares Geraet, das die Sicherheitsdiagnose sowie die voraussichtliche Lebensdauer per Lichtanzeige angibt. K-Store ist ein Computerprogramm, das die Daten ausarbeitet und damit die Optimierung der Unterhaltskosten ermoeglicht. (orig.)

  12. Classification bias in commercial business lists for retail food stores in the U.S.

    Directory of Open Access Journals (Sweden)

    Han Euna

    2012-04-01

    Full Text Available Abstract Background Aspects of the food environment such as the availability of different types of food stores have recently emerged as key modifiable factors that may contribute to the increased prevalence of obesity. Given that many of these studies have derived their results based on secondary datasets and the relationship of food stores with individual weight outcomes has been reported to vary by store type, it is important to understand the extent to which often-used secondary data correctly classify food stores. We evaluated the classification bias of food stores in Dun & Bradstreet (D&B and InfoUSA commercial business lists. Methods We performed a full census in 274 randomly selected census tracts in the Chicago metropolitan area and collected detailed store attributes inside stores for classification. Store attributes were compared by classification match status and store type. Systematic classification bias by census tract characteristics was assessed in multivariate regression. Results D&B had a higher classification match rate than InfoUSA for supermarkets and grocery stores, while InfoUSA was higher for convenience stores. Both lists were more likely to correctly classify large supermarkets, grocery stores, and convenience stores with more cash registers and different types of service counters (supermarkets and grocery stores only. The likelihood of a correct classification match for supermarkets and grocery stores did not vary systemically by tract characteristics whereas convenience stores were more likely to be misclassified in predominately Black tracts. Conclusion Researches can rely on classification of food stores in commercial datasets for supermarkets and grocery stores whereas classifications for convenience and specialty food stores are subject to some systematic bias by neighborhood racial/ethnic composition.

  13. Research on Development Rule of Retail Store in China's Fashion Market

    Institute of Scientific and Technical Information of China (English)

    WAN Yan-min; JIANG Zhi-wei

    2002-01-01

    Retail store is one of key contents of fashion marketing management. From the point of theory of three spaces in store, Shanghai - China's most important fashion retailing market, is taken as a research sample. Store types, transform rule and relative factors of China's fashion retailing market are discussed. Some problems,such as agreement of store quality and brand target, are analyzed. Finally, five basic conclusions are drawn:first, development of store has been simultaneous with the development of fashion retailing market; second,development speed of store is restrained by region economy objectively; third, the effective means of upgrading marketing level of fashion brand presupposes improving the whole quality of store; fourth, the model of store is index reflecting competitive ability of fashion brand; fifth, there is obvious difference between domestic fashion store and that of international important area.

  14. Greenhouse Gas Emissions from Stored Dairy Slurry from Multiple Farms.

    Science.gov (United States)

    Le Riche, Etienne L; VanderZaag, Andrew C; Wood, Jeffrey D; Wagner-Riddle, Claudia; Dunfield, Kari; Ngwabie, N Martin; McCabe, John; Gordon, Robert J

    2016-11-01

    A significant need exists to improve our understanding of the extent of greenhouse gas emissions from the storage of livestock manure to both improve the reliability of inventory assessments and the impact of beneficial management practice adoption. Factors affecting the extent and variability of greenhouse gas emissions from stored dairy manure were investigated. Emissions from six slurries stored in clean concrete tanks under identical "warm-season" conditions were monitored consecutively over 173 d (18°C average air temperature). Methane (CH) emissions varied considerably among the manures from 6.3 to 25.9 g m d and accounted for ∼96% of the total CO equivalent greenhouse gas emissions. The duration of the lag period, when methane emissions were near baseline levels, varied from 30 to 90 d from the beginning of storage. As a result, CH emissions were poorly correlated with air temperature prior to the time of peak emissions (i.e., the initial 48 to 108 d of storage) but improved afterward. The air temperature following the time of the peak CH flux and the length of the active methanogenesis period (i.e., when the daily CH emissions ≥ 7.6 g m d) were highly correlated with CH emissions ( = 0.98, < 0.01). Methane conversion factors (MCFs) ranged from 0.08 to 0.52 for the different manures. The MCFs generated from existing CH emission models were correlated ( = 0.68, = 0.02) to MCFs calculated for the active methanogenesis period for manure containing wood bedding. A temperature component was added that improved the accuracy ( = 0.82, < 0.01). This demonstrated that an improved understanding of lag period dynamics will enhance stored dairy manure greenhouse gas emission inventory calculations.

  15. Evaluating the STORE Reputation System in Multi-Agent Simulations

    Science.gov (United States)

    Andrulis, Jonas; Haller, Jochen; Weinhardt, Christof; Karabulut, Yuecel

    In recent global business environments, collaborations among organisations raise an increased demand for swift establishment. Such collaborations are formed between organisations entering Virtual Organizations (VOs), crossing geographic borders and frequently without prior experience of the other partner’s previous performance. In VOs, every participant risks engaging with partners who may exhibit unexpected fraudulent or otherwise untrusted behaviour. In order to cope with this risk, the STochastic REputation system (STORE) was designed to provide swift, automated decision support for selecting partner organisations in the early stages of the VO’s formation. The contribution of this paper first consists of a multi-agent simulation framework design and implementation to evaluate the STORE reputation system. This framework is able to simulate dynamic agent behaviour, agents hereby representing organisations, and to capture the business context of different VO application scenarios. A configuration of agent classes is a powerful tool to obtain not only well or badly performing agents for simulation scenarios, but also agents which are specialized in particular VO application domains or even malicious agents, attacking the VO community. The second contribution comprises of STORE’s evaluation in two simulation scenarios, set in the VO application domains of Collaborative Engineering and Ad-hoc Service provisioning. Besides the ability to clearly distinguish between agents of different classes according to their reputation, the results prove STORE’s ability to take an agent’s dynamic behaviour into account. The simulation results show, that STORE solves the difficult task of selecting the most trustworthy partner for a particular VO application domain from a set of honest agents that are specialized in a wide spread of VO application domains.

  16. Electron, photons, and molecules: Storing energy from light

    Energy Technology Data Exchange (ETDEWEB)

    Miller, J.R. [Argonne National Laboratory, IL (United States)

    1996-09-01

    Molecular charge separation has important potential for photochemical energy storage. Its efficiency can be enhanced by principals which maximize the rates of the electron transfer steps which separate charge and minimize those which recombine high-energy charge pairs to lose stored energy. Dramatic scientific progress in understanding these principals has occurred since the founding of DOE and its predecessor agency ERDA. While additional knowledge in needed in broad areas of molecular electron transfer, some key areas of knowledge hold particular promise for the possibility of moving this area from science toward technology capable of contributing to the nation`s energy economy.

  17. Fundamental tests of nature with cooled and stored exotic ions

    CERN Document Server

    CERN. Geneva

    2014-01-01

    The presentation will concentrate on recent applications with exciting results of Penning traps in atomic and nuclear physics with cooled and stored exotic ions. These are high-accuracy mass measurements of short-lived radionuclides, g-factor determinations of the bound-electron in highly-charged, hydrogen-like ions and g-factor measurements of the proton and antiproton. The experiments are dedicated, e.g., to astrophysics studies and to tests of fundamental symmetries in the case of mass measurements on radionuclides, and to the determination of fundamental constants and a CPT test in the case of the g-factor measurements.

  18. Monitoring the viability of citrus rootstocks seeds stored under refrigeration

    Directory of Open Access Journals (Sweden)

    Sérgio Alves de Carvalho

    2013-03-01

    Full Text Available The citrus nursery tree is produced through the bud grafting process, in which rootstock is usually grown from seed germination. The objective of this research was to evaluate, in two dissimilar environmental conditions, the viability and polyembryony expression of five citrus rootstocks seeds stored in different periods under refrigeration. The rootstock varieties evaluated were: Rangpur lime (Citrus limonia Osb. cv. Limeira, Trifoliate orange (Poncirus trifoliata Raf. cv. Limeira, Citrumelo (P. trifoliata x C. paradisi Macf. cv. Swingle, Sunki mandarin (C. sunki Hort. ex Tanaka and Volkamer lemon (C. volkameriana Ten. & Pasq. cv. Catania 2. The experimental design was the randomized blocks in a 11 x 5 x 2 factorial scheme, evaluating from time zero to the tenth month of storage, the five varieties of rootstock in two environments: germination and growth B.O.D type chamber (Biological Oxygen Demand - Eletrolab Brand Model FC 122 at 25 °C; and greenhouse seedbed with partial temperature control (22 °C to 36 °C and humidity control (75-85%. The plot had 24 seeds in four replicates, using trays with substrate in greenhouse and Petri dishes with filter paper in B.O.D. chamber. The seed germination rate and polyembryony expression were evaluated monthly. It was concluded that Trifoliate and Citrumelo Swingle seeds can be stored for up to seven months, while Volkamer lemon, Rangpur lime and Sunki seeds can be stored for up to ten months. The polyembryony expression rate was slightly higher when measured in greenhouse than in B.O.D. chamber and remained stable in both environments until the seventh month, from which dropped sharply. Citrumelo Swingle seeds expressed the highest polyembryony rate (18.8%, followed by Rangpur lime and Volkamer lemon (average value of 13.7%, Sunki (9.4% and Trifoliate (3.2%. Despite some differences among varieties, the viability of rootstock stored seeds can be monitored either in the greenhouse or in B

  19. Storing Solar Energy Performance on Rare Earth Windowpane

    Institute of Scientific and Technical Information of China (English)

    Li Baojun; Zhou Yao; Fu Li; Yang Tao; Li Tiansi; Li Ying

    2004-01-01

    The windowpane as the enclosure and decorative component of buildings is main part of energy consumption and the heat loss through window is almost 4% of the heating consumption in buildings. Using rare earth element,the glass can possess the performance of absorbing sunlight, storing heat, increasing the temperate of itself, and decreasing the inner heat load so as to play the double functions of saving energy and environmental protection. The experiment method of the rare earth windowpane, and analyses sunlight absorbing process of the rare earth element on photoelectric principle, and gives the changing curve with environment temperate -time of the rare earth windowpane surface were introduced.

  20. Quantifying App Store Dynamics: Longitudinal Tracking of Mental Health Apps

    Science.gov (United States)

    Nicholas, Jennifer; Christensen, Helen

    2016-01-01

    Background For many mental health conditions, mobile health apps offer the ability to deliver information, support, and intervention outside the clinical setting. However, there are difficulties with the use of a commercial app store to distribute health care resources, including turnover of apps, irrelevance of apps, and discordance with evidence-based practice. Objective The primary aim of this study was to quantify the longevity and rate of turnover of mental health apps within the official Android and iOS app stores. The secondary aim was to quantify the proportion of apps that were clinically relevant and assess whether the longevity of these apps differed from clinically nonrelevant apps. The tertiary aim was to establish the proportion of clinically relevant apps that included claims of clinical effectiveness. We performed additional subgroup analyses using additional data from the app stores, including search result ranking, user ratings, and number of downloads. Methods We searched iTunes (iOS) and the Google Play (Android) app stores each day over a 9-month period for apps related to depression, bipolar disorder, and suicide. We performed additional app-specific searches if an app no longer appeared within the main search Results On the Android platform, 50% of the search results changed after 130 days (depression), 195 days (bipolar disorder), and 115 days (suicide). Search results were more stable on the iOS platform, with 50% of the search results remaining at the end of the study period. Approximately 75% of Android and 90% of iOS apps were still available to download at the end of the study. We identified only 35.3% (347/982) of apps as being clinically relevant for depression, of which 9 (2.6%) claimed clinical effectiveness. Only 3 included a full citation to a published study. Conclusions The mental health app environment is volatile, with a clinically relevant app for depression becoming unavailable to download every 2.9 days. This poses

  1. The molecular choreography of a store-operated calcium channel.

    Science.gov (United States)

    Lewis, Richard S

    2007-03-15

    Store-operated calcium channels (SOCs) serve essential functions from secretion and motility to gene expression and cell growth. A fundamental mystery is how the depletion of Ca2+ from the endoplasmic reticulum (ER) activates Ca2+ entry through SOCs in the plasma membrane. Recent studies using genetic approaches have identified genes encoding the ER Ca2+ sensor and a prototypic SOC, the Ca2+-release-activated Ca2+ (CRAC) channel. New findings reveal a unique mechanism for channel activation, in which the CRAC channel and its sensor migrate independently to closely apposed sites of interaction in the ER and the plasma membrane.

  2. Negative price-image effects of appealing store architecture

    DEFF Research Database (Denmark)

    Zielke, Stephan; Toporowski, Waldemar

    2012-01-01

    Retailers often worry about the negative effects of appealing exterior architecture on their store's price image, especially the price-level perception and the ease of price evaluation. Findings from prior laboratory experiments support these concerns, while field studies find no such effects....... The present study explains this inconsistency by analyzing the moderating effects of price and retail brand information available to customers in real shopping situations. The results show that negative effects of appealing exterior architecture do not exist when retail brand information is available...

  3. Det store sammenhængskollaps på Facebook

    DEFF Research Database (Denmark)

    Tække, Jesper

    2016-01-01

    Det store sammenhængskollaps på Facebook: Politik og massemedier erstatter mere og mere de private billeder og statusopdateringer på Facebook. Vi er blevet mere og mere upersonlige og mindre og mindre private, når vi deler på Facebook. Dette viser fortrolige oplysninger fra medarbejdere på Facebook...... ifølge teknologimediet The Information. En stor krise og et kollaps truer Facebook, som nu prøver at løse problemet ved eksempelvis at gøre det lettere at dele personlige og private oplevelser....

  4. Computations of the unsteady flow about a generic wing/pylon/finned-store configuration

    Science.gov (United States)

    Meakin, Robert L.

    1992-01-01

    An overset grid approach is used to carry out a set of computations of the unsteady flow about a generic wing, pylon, and finned-store configuration. The geometry, discretization procedure, and governing equations are presented. Thin-layer Navier-Stokes solutions are presented for four store separation cases: store in carriage position, store at two different separation positions, and a time-accurate simulation of the forced store separation from the wing pylon carriage. Computational results are compared with wind tunnel data for the three 'static store' cases. Dynamic loads and trajectory data are presented for the forced separation case.

  5. Demand-driven energy supply from stored biowaste for biomethanisation.

    Science.gov (United States)

    Aichinger, Peter; Kuprian, Martin; Probst, Maraike; Insam, Heribert; Ebner, Christian

    2015-10-01

    Energy supply is a global hot topic. The social and political pressure forces a higher percentage of energy supplied by renewable resources. The production of renewable energy in form of biomethane can be increased by co-substrates such as municipal biowaste. However, a demand-driven energy production or its storage needs optimisation, the option to store the substrate with its inherent energy is investigated in this study. The calorific content of biowaste was found unchanged after 45 d of storage (19.9±0.19 kJ g(-1) total solids), and the methane yield obtained from stored biowaste was comparable to fresh biowaste or even higher (approx. 400 m(3) Mg(-1) volatile solids). Our results show that the storage supports the hydrolysis of the co-substrate via acidification and production of volatile fatty acids. The data indicate that storage of biowaste is an efficient way to produce bioenergy on demand. This could in strengthen the role of biomethane plants for electricity supply the future.

  6. Video Contents Prior Storing Server For Lte Networks

    Directory of Open Access Journals (Sweden)

    Tony Tsang

    2015-10-01

    Full Text Available One of the most important multimedia applications is Internet protocol TV (IPTV for next-generation networks. IPTV provides triple-play services that require high-speed access networks with the functions of multicasting and quality of service (QoS guarantees. Among 4G mobile ac-cess networks, LTE networks are regarded as among the best solutions to meet higher bandwidth demands. In this paper, we propose a new architecture for multicasting live IPTV traffic in 4G LTE networks. The proposed mechanism involves assigning a unique logical link identifier to each IPTV channel. To manage multicasting, a prior storing server in the Base Station and in each mobile network unit, mobile phone, is constructed. In this work, we propose a partial prior storing strategy that considers the changes in the popularity of the video content segments over time and the access patterns of the users to compute the utility of the objects in the prior storage. We also propose to partition the prior storage to avoid the eviction of the popular objects (those not accessed frequently by the unpopular ones which are accessed with higher frequency. The popularity distribution and ageing of popularity are measured from two online datasets and use the parameters in simulations. Simulation results show that our proposed architecture can improve the system performance and QoS parameters in terms of packet delay, jitter and packet loss.

  7. VIDEO CONTENTS PRIOR STORING SERVER FOR OPTICAL ACCESS NETWORK

    Directory of Open Access Journals (Sweden)

    Tony Tsang

    2015-03-01

    Full Text Available One of the most important multimedia applications is Internet protocol TV (IPTV for next-generation networks. IPTV provides triple-play services that require high-speed access networks with the functions of multicasting and quality of service (QoS guarantees. Among optical access networks, Ethernet passive optical networks (EPONs are regarded as among the best solutions to meet higher bandwidth demands. In this paper, we propose a new architecture for multicasting live IPTV traffic in optical access network. The proposed mechanism involves assigning a unique logical link identifier to each IPTV channel. To manage multicasting, a prior storing server in the optical line terminal (OLT and in each optical network unit (ONU is constructed. In this work, we propose a partial prior storing strategy that considers the changes in the popularity of the video content segments over time and the access patterns of the users to compute the utility of the objects in the prior storage. We also propose to partition the prior storage to avoid the eviction of the popular objects (those not accessed frequently by the unpopular ones which are accessed with higher frequency. The popularity distribution and ageing of popularity are measured from two online datasets and use the parameters in simulations. Simulation results show that our proposed architecture can improve the system performance and QoS parameters in terms of packet delay, jitter and packet loss

  8. Organizational Stress for Retail Store Employees in Romania

    Directory of Open Access Journals (Sweden)

    Alina - Cerasela Aluculesei

    2015-03-01

    Full Text Available The term organizational stress appeared with people’s lifestyle and job evolution and it is used to show the direct link between the work environment and the employee’s wellbeing or health. This concept exists in all countries, and measures taken to decrease its effects are becoming increasingly more obvious. Such measures are being implemented in Romania also and, given the country’s high spa tourism potential, treatment programs in spa resorts would be the most obvious measures to decrease organizational stress and recover employee productivity. This study aims to address the main concepts related to organizational stress and to present the main benefits related to treatment of organizational stress in Romanian spa resorts. This research was carried out on 101 retail store employees of a supermarket chain. This job, due the requirements, is associated with high levels of stress. The data were processed using the Epi Info statistical software. From the analysis we conducted resulted that the employees we questioned have a low degree of personal satisfaction – in 57% of cases, declaring that their lifestyle since employment as retail store employees is less healthy, with fewer outdoor recreational activities - 65%. In regards to the presence of organizational stress, there are various associated symptoms, with correlation between headaches and increased heart rate (p value=0,003, insomnia (p value = 0,006 or back pain (p value=0,042.

  9. Occupant Perceptions and a Health Outcome in Retail Stores

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Mingjie; Kim, Yang-Seon; Srebric, Jelena

    2015-11-02

    Indoor Environmental Quality (IEQ) in commercial buildings, such as retail stores, can affect employee satisfaction, productivity, and health. This study administered an IEQ survey to retail employees and found correlations between measured IEQ parameters and the survey responses. The survey included 611 employees in 14 retail stores located in Pennsylvania (climate zone 5A) and Texas (climate zone 2A). The survey questionnaire featured ratings of different aspects of IEQ, including thermal comfort, lighting and noise level, indoor smells, overall cleanness, and environmental quality. Simultaneously with the survey, on-site physical measurements were taken to collect data of relative humidity levels, air exchange rates, dry bulb temperatures, and contaminant concentrations. This data was analyzed using multinomial logit regression with independent variables being the measured IEQ parameters, employees’ gender, and age. This study found that employee perception of stuffy smells is related to formaldehyde and PM10 concentrations. Furthermore, the survey also asked the employees to report an annual frequency of common colds as a health indicator. The regression analysis showed that the cold frequency statistically correlates with the measured air exchange rates, outdoor temperatures, and indoor PM concentrations. Overall, the air exchange rate is the most influential parameter on the employee perception of the overall environmental quality and self-reported health outcome.

  10. Mites associated with stored grain commodities in Benin, West Africa.

    Science.gov (United States)

    Zannou, Ignace D; Adebo, Habib O; Zannou, Elisabeth; Hell, Kerstin

    2013-12-01

    After insects, mites are the major arthropod pests that inhabit stored agricultural products worldwide. To determine the acarofauna that infests cowpea, maize, paddy rice and sorghum in Benin (West Africa), surveys were conducted in some principal markets (Dantokpa, Glazoue and Parakou) of this country. A total of 555 samples of grains and debris were collected in May and September 2011. More than 56 species belonging to 24 mite families were recorded in the four products. These mite species included predators, parasites, fungivorous, phytophagous and other groups whose feeding habits are not well known. The family Cheyletidae was the most prevalent and the most diverse predatory mite family encountered, in which Cheyletus malaccensis Oudemans was the most abundant species. Several families of mite pests and mites responsible for allergies (Acaridae, Glycyphagidae, Pyroglyphidae, Pyemotidae and Saproglyphidae) were also detected. The three most dominant and frequent species were C. malaccensis, Suidasia nesbitti (Hughes) and Suidasia sp. Statistical analysis showed that densities of these three mite species were higher in Parakou than in Glazoue and Dantokpa, on one hand, and higher in debris than in grains, on the other hand. The densities of S. nesbitti and Suidasia sp. decreased significantly during the dry season, whereas C. malaccensis remained stable throughout the two samplings. Of all grains, sorghum was the least infested with mites. This study shows that in Benin mites are present in stored agricultural products to which they cause serious damage, and may cause various allergies to people.

  11. Store Impulse Marketing Strategies and Body Mass Index

    Science.gov (United States)

    Collins, Rebecca; Hunter, Gerald; Ghosh-Dastidar, Bonnie; Dubowitz, Tamara

    2015-01-01

    Objectives. We quantified the use of placement and price reduction marketing strategies in different food retail outlets to identify associations between these strategies and the risk of overweight and obesity among customers. Methods. In 2011 we collected dietary and health information from 1372 residents in “food deserts” in Pittsburgh, PA. We audited neighborhood restaurants and food stores (n = 40) including 16 distant food venues at which residents reported shopping. We assessed end-aisle displays, special floor displays, cash register displays, and price reductions for sugar-sweetened beverages (SSBs); foods high in saturated oils, fats, and added sugars; and nutritious foods such as fruits, vegetables, and products with at least 51% whole grains. Results. Supermarkets and superstores had the largest numbers of displays and price reductions for low-nutrient foods. Exposure to displays of SSBs and foods high in saturated oils, fats, and added sugars and price reduction of SSBs was associated with increased body mass index. Conclusions. In-store marketing strategies of low-nutrient foods appear to be risk factors for a higher body mass index among regular shoppers. Future research is needed to confirm the causal role of marketing strategies in obesity. PMID:25521881

  12. The CALBC RDF Triple Store: retrieval over large literature content

    CERN Document Server

    Croset, Samuel; Li, Chen; Kavaliauskas, Silvestras; Rebholz-Schuhmann, Dietrich

    2010-01-01

    Integration of the scientific literature into a biomedical research infrastructure requires the processing of the literature, identification of the contained named entities (NEs) and concepts, and to represent the content in a standardised way. The CALBC project partners (PPs) have produced a large-scale annotated biomedical corpus with four different semantic groups through the harmonisation of annotations from automatic text mining solutions (Silver Standard Corpus, SSC). The four semantic groups were chemical entities and drugs (CHED), genes and proteins (PRGE), diseases and disorders (DISO) and species (SPE). The content of the SSC has been fully integrated into RDF Triple Store (4,568,678 triples) and has been aligned with content from the GeneAtlas (182,840 triples), UniProtKb (12,552,239 triples for human) and the lexical resource LexEBI (BioLexicon). RDF Triple Store enables querying the scientific literature and bioinformatics resources at the same time for evidence of genetic causes, such as drug ta...

  13. CNV-WebStore: Online CNV Analysis, Storage and Interpretation

    Directory of Open Access Journals (Sweden)

    Wuyts Wim

    2011-01-01

    Full Text Available Abstract Background Microarray technology allows the analysis of genomic aberrations at an ever increasing resolution, making functional interpretation of these vast amounts of data the main bottleneck in routine implementation of high resolution array platforms, and emphasising the need for a centralised and easy to use CNV data management and interpretation system. Results We present CNV-WebStore, an online platform to streamline the processing and downstream interpretation of microarray data in a clinical context, tailored towards but not limited to the Illumina BeadArray platform. Provided analysis tools include CNV analsyis, parent of origin and uniparental disomy detection. Interpretation tools include data visualisation, gene prioritisation, automated PubMed searching, linking data to several genome browsers and annotation of CNVs based on several public databases. Finally a module is provided for uniform reporting of results. Conclusion CNV-WebStore is able to present copy number data in an intuitive way to both lab technicians and clinicians, making it a useful tool in daily clinical practice.

  14. Activity of some isoenzymatic systems in stored coffee grains

    Directory of Open Access Journals (Sweden)

    Reni Saath

    2014-02-01

    Full Text Available Considering the worldwide consumption of coffee, it is natural that throughout the history many people have dedicated the research to markers that contribute somehow on gauging its quality. This research aimed to evaluate the biochemical performance of arabica coffee during storage. Coffee in beans (natural and in parchment (pulped dried in concrete terrace and in dryer with heated air were packed in jute bags and stored in not controlled environmental conditions. Enzymatic activities of superoxide dismutase, catalase, peroxidase, polyphenoloxidase, esterase and lipoxygenase in coffee grains were evaluated at zero, three, six, nine and twelve months by means of electrophoresis. Independently of the drying method, the activity of isoenzymatic complexes highlighted deteriorative processes in stored grains of coffee. The treatments 60/40º C and 60º C used to reduce the water content imposed a greater stress condition, accelerated metabolism of natural coffee in the storage with decreased activity of defense mechanisms due to latent damage in these grains. Natural coffees are more sensible to high drying temperatures and its quality reduces faster than pulped coffee in the storage.

  15. Operation of the Australian Store.Synchrotron for macromolecular crystallography.

    Science.gov (United States)

    Meyer, Grischa R; Aragão, David; Mudie, Nathan J; Caradoc-Davies, Tom T; McGowan, Sheena; Bertling, Philip J; Groenewegen, David; Quenette, Stevan M; Bond, Charles S; Buckle, Ashley M; Androulakis, Steve

    2014-10-01

    The Store.Synchrotron service, a fully functional, cloud computing-based solution to raw X-ray data archiving and dissemination at the Australian Synchrotron, is described. The service automatically receives and archives raw diffraction data, related metadata and preliminary results of automated data-processing workflows. Data are able to be shared with collaborators and opened to the public. In the nine months since its deployment in August 2013, the service has handled over 22.4 TB of raw data (∼1.7 million diffraction images). Several real examples from the Australian crystallographic community are described that illustrate the advantages of the approach, which include real-time online data access and fully redundant, secure storage. Discoveries in biological sciences increasingly require multidisciplinary approaches. With this in mind, Store.Synchrotron has been developed as a component within a greater service that can combine data from other instruments at the Australian Synchrotron, as well as instruments at the Australian neutron source ANSTO. It is therefore envisaged that this will serve as a model implementation of raw data archiving and dissemination within the structural biology research community.

  16. FOOD SAFETY SYSTEMS’ FUNCTIONING IN POLISH NETWORKS OF GROCERY STORES

    Directory of Open Access Journals (Sweden)

    Paweł NOWICKI

    2013-04-01

    Full Text Available This article shows the way how the food safety systems are functioning in Polish networks of grocery stores. The study was conducted in the fourth quarter of 2012 in the south‐eastern Poland. There were chosen three organizations that meet certain conditions: medium size Polish grocery network without participation of foreign capital and up to 30 retail locations within the group. Studies based on a case study model. The research found that regular and unannounced inspections carried out to each store's, impact on increasing safety of food offered and the verification of GHP requirements on the headquarters level has a significant impact on the safety of food offered as well as on the knowledge and behavior of employees. In addition it was found that the verification and analysis of food safety management system is an effective tool for improving food safety. It was also shown that in most cases there is no formal crisis management system for the food protection in the surveyed companies and employees are only informed of what to do in case of an emergency.

  17. Determining host suitability of pecan for stored-product insects.

    Science.gov (United States)

    Shufran, A A; Mulder, P G; Payton, M E; Shufran, K A

    2013-04-01

    A no-choice test was performed to determine survival and reproductive capacity of stored-product insect pests on pecan, Carya illinoensis (Wangenheim) Koch. Insects used were Indianmeal moth, Plodia interpunctella (Hübner) (Lepidoptera: Pyralidae); sawtoothed grain beetle, Oryzaephilus surinamensis (L.) (Coleoptera: Cucujidae); red flour beetle, Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae); lesser grain borer, Rhyzopertha dominica (F.) (Coleoptera: Bostrichidae); and rusty grain beetle, Cryptolestes ferrugineus (Stephens) (Coleoptera: Laemophloeidae). Fifty adults of each beetle species or 10 reproductive pairs of P. interpunctella adults were placed in 0.5-liter containers with either whole-shell pecans, cracked-shell pecans, randomly selected in-shell pecans, pecan nutmeats, cracked wheat, or glass beads and held at 28 degrees C, 60-70% relative humidity, and 16:8 (L:D) photoperiod for 2, 4, 6, and 8 wk. Four replications of each insect-diet-interval combination were performed. Larvae of P. interpunctella, O. surinamensis, T. castaneum, C. ferrugineus, and adult P. interpunctella and O. surinamensis developed on cracked and nutmeat pecan diets. R. dominica did not complete reproduction on pecans. Knowledge that these pests can reproduce on stored pecan will assist pecan growers, accumulators, and storage facilities in preventing insect outbreaks on their product.

  18. Drivers Of Customer Loyalty In A Retail Store Environment

    Directory of Open Access Journals (Sweden)

    Toyin A. Clottey

    2011-05-01

    Full Text Available The determinants of customer loyalty are identified for a large U.S. retailer based on a survey of 972 customers.  An ordered logistic regression is used to estimate the proportion of a retailer’s customers who are willing to recommend the retailers products to others based on survey results.Statistical results document that service quality, product quality and brand image drive customer loyalty as measured by a customer’s willingness to recommend the retailer’s products to other people.  Service management managers can improve these drivers of customer loyalty by better training, recognition and reward programs, day-to-day store operations, and job, product, process and store design.  Given the general research objective of defining a universal model of what drives customer loyalty in a diverse set of industries, this research provides additional statistical evidence to support the theory that brand image, product quality, and service quality determine customer loyalty. 

  19. 'Teen' Finds Minors Can Buy Bodybuilding Supplement At Health Food Stores

    Science.gov (United States)

    ... 162859.html 'Teen' Finds Minors Can Buy Bodybuilding Supplement at Health Food Stores Major medical associations advise against use of ... News) -- Many U.S. health food stores recommend the dietary supplement creatine to minors as an athletic performance enhancer, ...

  20. Analyzing the Efficient Execution of In-Store Logistics Processes in Grocery Retailing

    DEFF Research Database (Denmark)

    Reiner, Gerald; Teller, Christop; Kotzab, Herbert

    2013-01-01

    . In particular, we identify ways of improving in-store logistics processes by showing the performance impacts of different managerial strategies and tactics. The DEA results indicate different efficiency levels for different store formats; the hybrid store format of the small hypermarket exhibits a comparatively...... worse performance in the analyzed execution of in-store logistics processes. The process simulation analysis reveals that the strategic and tactical design of in-store logistics processes (such as store locations/layouts, capacity management, reorder time, order period, and safety stock factors) lead......In this article, we examine in-store logistics processes for handling dairy products, from the incoming dock to the shelves of supermarkets and hypermarkets. The efficient execution of the in-store logistics related to such fast-moving, sensitive, and essential items is challenging and crucial...

  1. Vision (im)possible? The effects of in-store signage on customers’ visual attention

    OpenAIRE

    Otterbring, Tobias; Wästlund, Erik; Gustafsson, Anders; Shams, Poja

    2014-01-01

    We used two eye-tracking field experiments to investigate the extent to which in-store signage is used during navigation and decision making, and how the viewing of signage influences customers’ visual attention and choice behavior. One hundred and seventy-five customers at a grocery store were exposed to signage stimuli while carrying out predefined shopping tasks. Experiment 1 shows that attention toward signage is affected by customers’ levels of store familiarity and in-store search stage...

  2. Modified Penning-Malmberg Trap for Storing Antiprotons

    Science.gov (United States)

    Sims, William H.; Martin, James; Lewis, Raymond

    2005-01-01

    A modified Penning-Malmberg trap that could store a small cloud of antiprotons for a relatively long time (weeks) has been developed. This trap is intended for use in research on the feasibility of contemplated future matter/antimatter-annihilation systems as propulsion sources for spacecraft on long missions. This trap is also of interest in its own right as a means of storing and manipulating antiprotons for terrestrial scientific experimentation. The use of Penning-Malmberg traps to store antiprotons is not new. What is new here is the modified trap design, which utilizes state-of-the-art radiofrequency (RF) techniques, including ones that, heretofore, have been used in radio-communication applications but not in iontrap applications. A basic Penning-Malmberg trap includes an evacuated round tube that contains or is surrounded by three or more collinear tube electrodes. A steady axial magnetic field that reaches a maximum at the geometric center of the tube is applied by an external source, and DC bias voltages that give rise to an electrostatic potential that reaches a minimum at the center are applied to the electrodes. The combination of electric and magnetic fields confines the charged particles (ions or electrons) for which it was designed to a prolate spheroidal central region. However, geometric misalignments and the diffusive cooling process prevent the steady fields of a basic Penning- Malmberg trap from confining the particles indefinitely. In the modified Penning-Malmberg trap, the loss of antiprotons is reduced or eliminated by use of a "rotating-wall" RF stabilization scheme that also heats the antiproton cloud to minimize loss by matter/antimatter annihilation. The scheme involves the superposition of a quadrupole electric field that rotates about the cylindrical axis at a suitably chosen radio frequency. The modified Penning-Malmberg trap (see Figure 1) includes several collinear sets of electrodes inside a tubular vacuum chamber. Each set

  3. Neighborhood impact on healthy food availability and pricing in food stores.

    Science.gov (United States)

    Krukowski, Rebecca A; West, Delia Smith; Harvey-Berino, Jean; Elaine Prewitt, T

    2010-06-01

    Availability and price of healthy foods in food stores has the potential to influence purchasing patterns, dietary intake, and weight status of individuals. This study examined whether demographic factors of the store neighborhood or store size have an impact on the availability and price of healthy foods in sample of grocery stores and supermarkets. The Nutrition Environment Measures Study-Store (NEMS-S) instrument, a standardized observational survey, was utilized to evaluate food stores (N = 42) in a multi-site (Vermont and Arkansas) study in 2008. Census data associated with store census tract (median household income and proportion African-American) were used to characterize store neighborhood and number of cash registers was used to quantify store size. Median household income was significantly associated with the NEMS healthy food availability score (r = 0.36, P store size (r = 0.27, P = 0.09) were significantly related to the Availability score. Larger store size (r = 0.40, P Price scores, indicating more favorable prices for healthier items; neither racial composition nor median household income were significantly related to the Price score (P's > 0.05). Even among supermarkets, healthier foods are less available in certain neighborhoods, although, when available, the quality of healthier options did not differ, suggesting that targeting availability may offer promise for policy initiatives. Furthermore, increasing access to larger stores that can offer lower prices for healthier foods may provide another avenue for enhancing food environments to lower disease risk.

  4. Effects of illumination on store atmosphere, price and quality perception, and shopping intention

    DEFF Research Database (Denmark)

    Zielke, Stephan; Schielke, Thomas

    This paper analyzes how store lighting influences store atmosphere, price and quality perception, and the intention to shop in a retail store. A first experiment shows how the number and brightness of light beams influence these dependent variables. Results demonstrate that especially extreme com...

  5. 7 CFR 1421.106 - Warehouse-stored marketing assistance loan collateral.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Warehouse-stored marketing assistance loan collateral... Marketing Assistance Loans § 1421.106 Warehouse-stored marketing assistance loan collateral. (a) A commodity may be pledged as collateral for a warehouse-stored marketing assistance loan in the...

  6. 7 CFR 160.203 - Fees for inspection and certification of other naval stores material.

    Science.gov (United States)

    2010-01-01

    ... stores material. 160.203 Section 160.203 Agriculture Regulations of the Department of Agriculture... Services Rendered § 160.203 Fees for inspection and certification of other naval stores material. Whenever..., analyze and certify any naval stores material other than spirits of turpentine or rosin, at the request...

  7. Retail store image in emerging markets: An initial study among Chinese retailers

    DEFF Research Database (Denmark)

    Hansen, Kåre

    This study explores the dimensions of store images and retailer's positioning in emerging markets. First, the store images of a retail segment will be assessed from the consumer's perspective. Second, store image clusters will be profiled based on a survey of the retailers; how they position...

  8. 32 CFR Appendix B to Part 231 - In-Store Banking

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false In-Store Banking B Appendix B to Part 231.... 231, App. B Appendix B to Part 231—In-Store Banking A. Selection Process. The purpose of this guidance... provide in-store banking services when such services are desired and approved by the...

  9. 76 FR 51308 - Retail Food Store Advertising and Marketing Practices Rule

    Science.gov (United States)

    2011-08-18

    ... CFR Part 424 Retail Food Store Advertising and Marketing Practices Rule AGENCY: Federal Trade... impact of the FTC's rule for ``Retail Food Store Advertising and Marketing Practices'' (``Unavailability... Store Advertising and Marketing Practices: Statement of Basis and Purpose: The Rule, 36 FR 8777 (May...

  10. 33 CFR 106.270 - Security measures for delivery of stores and industrial supplies.

    Science.gov (United States)

    2010-07-01

    ... stores and industrial supplies. 106.270 Section 106.270 Navigation and Navigable Waters COAST GUARD... stores and industrial supplies. (a) General. The OCS facility owner or operator must ensure that security measures relating to the delivery of stores or industrial supplies to the OCS facility are implemented...

  11. 77 FR 35336 - Privacy and Security of Information Stored on Mobile Communications Devices

    Science.gov (United States)

    2012-06-13

    ... COMMISSION 47 CFR Part 64 Privacy and Security of Information Stored on Mobile Communications Devices AGENCY... information stored on their users' mobile communications devices. In addition, the document seeks comment on... carriers to secure the privacy of customer information stored in mobile communications devices....

  12. Explaining Online Purchase Intentions: A Multi-Channel Store Image Perspective

    NARCIS (Netherlands)

    Dolen, van Willemijn; Verhagen, Tibert

    2007-01-01

    This study is one of the few empirical works addressing the impact of offline and online store impressions on consumer online purchase intentions. Building upon the literature on store image and consumer online purchasing, we propose positive effects of online store image and suggest mixed influence

  13. Men’s Suits Retail Sales in Top 22 BJ Department Stores Worth CNY202 million

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The retail sales data of Beijing department stores is based on the sales receipts of more than 20 Beijing department stores each month, the following is an analysis of the sales performance of men’s suits and stores by price range.

  14. The impact of category prices on store price image formation : An empirical analysis

    NARCIS (Netherlands)

    Da Silva Lourenço, C.J.; Gijsbrechts, E.; Paap, R.

    2015-01-01

    The authors empirically explore how consumers update beliefs about a store's overall expensiveness. They estimate a learning model of store price image (SPI) formation with the impact of actual prices linked to category characteristics, on a unique dataset combining store visit and purchase informat

  15. Microbial contamination of stored hydrocarbon fuels and its control

    Directory of Open Access Journals (Sweden)

    Gaylarde Christine C.

    1999-01-01

    Full Text Available The major microbial problem in the petroleum refining industry is contamination of stored products, which can lead to loss of product quality, formation of sludge and deterioration of pipework and storage tanks, both in the refinery and at the end-user. Three major classes of fuel are discussed in this article - gasoline, aviation kerosene and diesel, corresponding to increasingly heavy petroleum fractions. The fuel that presents the most serious microbiological problems is diesel. The many microorganisms that have been isolated from hydrocarbon fuel systems are listed. The conditions required for microbial growth and the methods used to monitor and to control this activity are discussed. The effects of various fuel additives, including biocides, are considered.

  16. Learning iPhone Programming From Xcode to App Store

    CERN Document Server

    Allan, Alasdair

    2010-01-01

    Get the hands-on experience you need to program for the iPhone and iPod Touch. With this easy-to-follow guide, you'll build several sample applications by learning how to use Xcode tools, the Objective-C programming language, and the core frameworks. Before you know it, you'll not only have the skills to develop your own apps, you'll know how to sail through the process of submitting apps to the iTunes App Store. Whether you're a developer new to Mac programming or an experienced Mac developer ready to tackle the iPhone and iPod Touch, Learning iPhone Programming will give you a head start o

  17. The Heidelberg CSR: Stored Ion Beams in a Cryogenic Environment

    Science.gov (United States)

    Wolf, A.; von Hahn, R.; Grieser, M.; Orlov, D. A.; Fadil, H.; Welsch, C. P.; Andrianarijaona, V.; Diehl, A.; Schröter, C. D.; Crespo López-Urrutia, J. R.; Rappaport, M.; Urbain, X.; Weber, T.; Mallinger, V.; Haberstroh, Ch.; Quack, H.; Schwalm, D.; Ullrich, J.; Zajfman, D.

    2006-03-01

    A cryogenic electrostatic ion storage ring CSR is under development at the Max-Planck Institute for Nuclear Physics in Heidelberg, Germany. Cooling of the ultrahigh vacuum chamber is envisaged to lead to extremely low pressures as demonstrated by cryogenic ion traps. The ring will apply electron cooling with electron beams of a few eV up to 200 eV. Through long storage times of 1000 s as well as through the low wall temperature, internal cooling of infrared-active molecular ions to their rotational ground state will be possible and their collisions with merged collinear beams of electrons and neutral atoms can be detected with high energy resolution. In addition storage of slow highly charged ions is foreseen. Using a fixed in-ring gas target and a reaction microscope, collisions of the stored ions at a spead of the order of the atomic unit can be kinematically reconstructed. The layout and the cryogenic concept are introduced.

  18. Time-dependent histamine release from stored human blood products

    DEFF Research Database (Denmark)

    Nielsen, Hans Jørgen; Edvardsen, L; Vangsgaard, K

    1996-01-01

    Perioperative transfusion of whole blood has been shown to amplify trauma-induced immunosuppression, which could be attenuated by perioperative administration of histamine2 receptor antagonists. Supernatants from different blood products were, therefore, analysed for histamine content during...... storage. Whole blood (six units), plasma-reduced whole blood (six units), and plasma- and buffy coat-reduced (saline-adenine-glucose-mannitol) (SAGM) blood (six units) from unpaid healthy donors were stored in the blood bank for 35 days at 4 degrees C. Plasma histamine and total cell-bound histamine...... content at donation, and histamine concentration in samples drawn from the units on days 0, 2, 5, 9, 14, 21, 28 and 35 were analysed with an enzyme-linked immunosorbent assay. Median plasma histamine concentration was 4.8 (range 1.9-14.3) nmol/l (n = 18). Median total cell-bound histamine content was 417...

  19. Recommender System for Sales at Material Store Using Fuzzy Tsukamoto

    Directory of Open Access Journals (Sweden)

    July Kurniawan

    2016-02-01

    Full Text Available The retail business has developed very rapidly, especially in Indonesia. One of them is material stores that have not applied the technology and still manual. In this modern era of buying and selling consumers need systems to assist in overcoming problems in terms of recommend items based on customer needs. The aim of this study is to determine the needs of consumers to recommend the necessary consumer goods. This system will simplify these processes, by utilizing information technology using Tsukamoto fuzzy logic. So that consumer demand for faster and more accurate in recommending goods could be accommodated. This research outlines what is needed to overcome the problems that had been experienced by consumers with a lack of information. The recommendations of this study is the form that refers to the percentage of goods from the predictions that have been studied previously.

  20. Diatomaceous earths as alternatives to chemical insecticides in stored grain

    Institute of Scientific and Technical Information of China (English)

    AMIN NIKPAY

    2006-01-01

    Diatomaceous earth (DE) is a natural inert dust used to control insect pests in stored grain as an alternative to synthetic residual insecticides. Various DE formulations are now registered as a grain protectant or for structural treatment in many different countries throughout the world. The mode of action of DE is through the absorption of cuticular waxes in the insect cuticle,and insect death occurs from desiccation. The main advantages of using DE are its low mammalian toxicity and its stability. The main limitations to widespread commercial use of DE are reduction of the bulk density and flowability of grain,irritant hazards during application and reduction in efficacy at high moisture contents. This paper is an updated review of published results of researches related to the use of DEs and discusses their potential use in large-scale,commercial storage and in small scale applications.

  1. Video-CRM: understanding customer behaviors in stores

    Science.gov (United States)

    Haritaoglu, Ismail; Flickner, Myron; Beymer, David

    2013-03-01

    This paper describes two real-time computer vision systems created 10 years ago that detect and track people in stores to obtain insights of customer behavior while shopping. The first system uses a single color camera to identify shopping groups in the checkout line. Shopping groups are identified by analyzing the inter-body distances coupled with the cashier's activities to detect checkout transactions start and end times. The second system uses multiple overhead narrow-baseline stereo cameras to detect and track people, their body posture and parts to understand customer interactions with products such as "customer picking a product from a shelf". In pilot studies both systems demonstrated real-time performance and sufficient accuracy to enable more detailed understanding of customer behavior and extract actionable real-time retail analytics.

  2. Advertising Discourse Analysis of FES stores: Killing Love, Cowards Show

    Directory of Open Access Journals (Sweden)

    Cristian Venegas Ahumada

    2013-08-01

    Full Text Available The objective is to analyze the structural and photographic discourse of the Autumn-Winter campaign 2008 of FES stores for young people. This was done by a semiotic theory and a critical-structural methodology of discourse. An analysis of 4 advertising photographs was done, and at once an analysis of the discourse “FES says no to violence against Women”, which explains the campaign’s target. The result is: The discourse was subjected to production condition (society of control and makes advertising a way to homogenize subjectivity of masses to consume. Recognition conditions demonstrate that this advertising discourse of symbolic violence means a type of violation of Men and Women Rights. An action like this requires commitment of Psychology in order to promote the social humanizing change, by means of university teaching and professional tasks.

  3. Crawl space assisted heat pump. [using stored ground heat

    Science.gov (United States)

    Ternes, M. P.

    1980-01-01

    A variety of experiments and simulations, currently being designed or underway, to determine the feasibility of conditioning the source air of an air to air heat pump using stored ground heat or cool to produce higher seasonal COP's and net energy savings are discussed. The ground would condition ambient air as it is drawn through the crawl space of a house. Tests designed to evaluate the feasibility of the concept, to determine the amount of heat or cool available from the ground, to study the effect of the system on the heating and cooling loads of the house, to study possible mechanisms which could enhance heat flow through the ground, and to determine if diurnal temperature swings are necessary to achieve successful system performance are described.

  4. Toxicity of cyanogen to insects of stored grain.

    Science.gov (United States)

    Hooper, Jacqueline L; Desmarchelier, James M; Ren, Yonglin; Allen, Sylvia E

    2003-03-01

    Range-finding studies on the toxicity of cyanogen to all stages of five species of stored product Coleoptera are reported. The species were Rhyzopertha dominica (F), Sitophilus granarius (L), Sitophilus Oryzae (L), Tribolium castaneum (Herbst), Tribolium confusum Jacquelin du Val and Ephestia cautella (Walker). Exposures for 24 h to cyanogen at 1.3 mg litre(-1) controlled all external stages. Control of internal stages of Sitophilus species was achieved by a 5-day exposure to initial concentrations between 13.7 and 27.4 mg litre(-1), whereas R. dominica was controlled at 13.7 mg litre(-1). Cyanogen showed similar toxicity to all tested external stages and, in this respect, was more similar to methyl bromide than to phosphine. Its toxicity to insects increased with both relative humidity and concentration of carbon dioxide. Cyanogen was toxic to insects whether applied as a gas or in an aqueous solution.

  5. Design Qualification of an External Store for a Fighter Aircraft

    Directory of Open Access Journals (Sweden)

    V.B. Goley

    2006-01-01

    Full Text Available Defence Avionics Research Establishment (DARE has designed and developed an externalstore for fitment on a fighter aircraft. The external store has the poded structure and can be usedfor installation of a variety of payloads up to 250 kg. The mechanical details of the electronicsto be fitted inside the pod can be worked out as per application. The pod has been designedkeeping this in mind and based on the functional, mechanical, structural, and aerodynamicrequirements. The designed and fabricated pod has undergone various qualification tests. Thepaper brings out the details of the pod design, and the various structural and environmentalqualification tests carried out. The pod thus designed and qualified has been validated throughcarriage trials by fitting the pod on the platform intended for it. The pod is likely to be inductedinto the Services shortly.

  6. Storing syngas lowers the carbon price for profitable coal gasification.

    Science.gov (United States)

    Newcomer, Adam; Apt, Jay

    2007-12-01

    Integrated gasification combined cycle (IGCC) electric power generation systems with carbon capture and sequestration have desirable environmental qualities but are not profitable when the carbon dioxide price is less than approximately $50 per metric ton. We examine whether an IGCC facility that operates its gasifier continuously butstores the syngas and produces electricity only when daily prices are high may be profitable at significantly lower CO2 prices. Using a probabilistic analysis, we have calculated the plant-level return on investment (ROI) and the value of syngas storage for IGCC facilities located in the U.S. Midwest using a range of storage configurations. Adding a second turbine to use the stored syngas to generate electricity at peak hours and implementing 12 h of above-ground high-pressure syngas storage significantly increases the ROI and net present value. Storage lowers the carbon price at which IGCC enters the U.S. generation mix by approximately 25%.

  7. Assessment of iron stores in anemic geriatric patients.

    Science.gov (United States)

    Patterson, C; Turpie, I D; Benger, A M

    1985-11-01

    Of patients referred to a geriatric service, 66 were identified who were clearly anemic (hemoglobin less than 12 g in men, less than 11 g in women) but whose cause of anemia was not readily identifiable by noninvasive measures. The difficulty in distinguishing iron deficiency from chronic disease as a cause of anemia by noninvasive means (serum iron, total iron binding capacity, transferrin saturation ratio, and serum ferritin), is highlighted by the poor power of these investigations when compared with bone marrow iron stores. A transferrin saturation ratio of less than 11% and a serum ferritin of less than 45 pg/L serve better than currently accepted values to identify iron deficiency in this population.

  8. Risk and Machine Protection for Stored Magnetic and Beam Energies

    CERN Document Server

    Todd, B

    2015-01-01

    Risk is a fundamental consideration when designing electronic systems. For most systems a view of risk can assist in setting design objectives, whereas both a qualitative and quantitative understanding of risk is mandatory when considering protection systems. This paper gives an overview of the risks due to stored magnetic and beam energies in high-energy physics, and shows how a risk-based approach can be used to design new systems mitigating these risks, using a lifecycle inspired by IEC 61508. Designing new systems in high-energy physics can be challenging as new and novel techniques are difficult to quantify and predict. This paper shows how the same lifecycle approach can be used in reverse to analyse existing systems, following their operation and first experiences.

  9. Many Facets of Strangeness Nuclear Physics with Stored Antiprotons

    CERN Document Server

    Pochodzalla, Josef; Lorente, Alicia Sanchez; Rojo, Marta Martinez; Steinen, Marcell; Gerl, Jürgen; Kojouharova, Jasmina; Kojouharova, Ivan

    2016-01-01

    Stored antiprotons beams in the GeV range represent a unparalleled factory for hyperon-antihyperon pairs. Their outstanding large production probability in antiproton collisions will open the floodgates for a series of new studies of strange hadronic systems with unprecedented precision. The behavior of hyperons and -- for the first time -- of antihyperons in nuclear systems can be studied under well controlled conditions. The exclusive production of $\\Lambda\\bar{\\Lambda}$ and $\\Sigma^-\\bar{\\Lambda}$ pairs in antiproton-nucleus interactions probe the neutron and proton distribution in the nuclear periphery and will help to sample the neutron skin. For the first time, high resolution $\\gamma$-spectroscopy of doubly strange nuclei will be performed, thus complementing measurements of ground state decays of double hypernuclei with mesons beams at J-PARC or possible decays of particle unstable hypernuclei in heavy ion reactions. High resolution spectroscopy of multistrange $\\Xi$-atoms are feasible and even the pr...

  10. Reply to Comments on "Stored energies and radiation Q"

    CERN Document Server

    Geyi, Wen

    2015-01-01

    It will be shown that the comment [1] contains numerous errors, misconceptions, inaccuracies, false assumptions, misunderstandings and unjustified claims. The analysis of the comment is built on a false assumption that the terminal current of an antenna fed by a waveguide is independent of frequency. This false assumption arises from the misunderstandings on the basic theory of transmission lines and misconceptions of normalization for a linear system. As a result, all the equations obtained from the assumption in the comment are incorrect, and the related discussions are untruthful. The delta gap source modeling has been abused in the comment, and this is reflected in the numerical results in the comment that give rise to negative stored energy. The main results of the commented paper have been misinterpreted by the authors of the comment, and the related analysis is established on illogical reasoning. The comment fails to pinpoint any errors in the commented paper. Instead, it reveals that the main results ...

  11. Quantified Risk Assessment for Plants Producing and Storing Explosives

    Institute of Scientific and Technical Information of China (English)

    Ioannis A. Papazoglou; Panagiotis Saravanos; Ieronymos Giakoumatos; Olga N. Aneziris

    2006-01-01

    This paper presents a methodology for risk assessment of plants producing and storing explosives. The major procedural steps for quantified risk assessment (QRA) in explosive plants are the following: hazard identification, accident sequence modeling, data acquisition, accident sequence quantification, consequence assessment and integration of results.This methodology is demonstrated and applied in an explosive plant consisting of four separate units, which produce detonating cord, nitroglycol, dynamites and ammonium nitrate fuel oil (ANFO). A GIS platform is used for depicting individual risk from explosions in this plant. Total individual risk is equal to 1.0 × 10-4/y in a distance of 340m from the center of the plant, and 1.0 × 10-6/y in a distance of 390m from the center of the plant.

  12. Staling of wheat bread stored in modified atmosphere

    DEFF Research Database (Denmark)

    Rasmussen, Peter Have; Hansen, A.

    2001-01-01

    demonstrated that storage of bread in MAP could be used to extend the microbial shelf-life without affecting the staling rate. The development of bread firmness during storage in 100% CO2 for 49 days was,found to be correlated to amylopectin retrogradation and to changes in the freezable water fraction...... containing 100% CO2 and in a mixture gas of 50% CO2 and 50% N-2, respectively. The control bread was packed in atmospheric air. No significant effects of MAP were found during storage of bread for 7 days at 20 degreesC compared to control bread. when changes in bread firmness and starch retrogradation...... measured by differential scanning calorimetry (DSC) were used as parameters for the staling rates. Ira addition, no significant differences were obtained in firmness between bread stored in 100% CO,, and in the mixture gas of CO2 and N-2 after 7 and 14 days, respectively. The present study thus...

  13. Highly confined ions store charge more efficiently in supercapacitors.

    Science.gov (United States)

    Merlet, C; Péan, C; Rotenberg, B; Madden, P A; Daffos, B; Taberna, P-L; Simon, P; Salanne, M

    2013-01-01

    Liquids exhibit specific properties when they are adsorbed in nanoporous structures. This is particularly true in the context of supercapacitors, for which an anomalous increase in performance has been observed for nanoporous electrodes. This enhancement has been traditionally attributed in experimental studies to the effect of confinement of the ions from the electrolyte inside sub-nanometre pores, which is accompanied by their partial desolvation. Here we perform molecular dynamics simulations of realistic supercapacitors and show that this picture is correct at the microscopic scale. We provide a detailed analysis of the various environments experienced by the ions. We pick out four different adsorption types, and we, respectively, label them as edge, planar, hollow and pocket sites upon increase of the coordination of the molecular species by carbon atoms from the electrode. We show that both the desolvation and the local charge stored on the electrode increase with the degree of confinement.

  14. Studies of Atomic Free Radicals Stored in a Cryogenic Environment

    Science.gov (United States)

    Lee, David M.; Hubbard, Dorthy (Technical Monitor); Alexander, Glen (Technical Monitor)

    2003-01-01

    Impurity-Helium Solids are porous gel-like solids consisting of impurity atoms and molecules surrounded by thin layers of solid helium. They provide an ideal medium for matrix isolation of free radicals to prevent recombination and store chemical energy. In this work electron spin resonance, nuclear magnetic resonance, X-ray diffraction, and ultrasound techniques have all been employed to study the properties of these substances. Detailed studies via electron spin resonance of exchange tunneling chemical reactions involving hydrogen and deuterium molecular and atomic impurities in these solids have been performed and compared with theory. Concentrations of hydrogen approaching the quantum solid criterion have been produced. Structured studies involving X ray diffraction, ultrasound, and electron spin resonance have shown that the impurities in impurity helium solids are predominantly contained in impurity clusters, with each cluster being surrounded by thin layers of solid helium.

  15. Low-level stored waste inspection using mobile robots

    Energy Technology Data Exchange (ETDEWEB)

    Byrd, J.S.; Pettus, R.O.

    1996-06-01

    A mobile robot inspection system, ARIES (Autonomous Robotic Inspection Experimental System), has been developed for the U.S. Department of Energy to replace human inspectors in the routine, regulated inspection of radioactive waste stored in drums. The robot will roam the three-foot aisles of drums, stacked four high, making decisions about the surface condition of the drums and maintaining a database of information about each drum. A distributed system of onboard and offboard computers will provide versatile, friendly control of the inspection process. This mobile robot system, based on a commercial mobile platform, will improve the quality of inspection, generate required reports, and relieve human operators from low-level radioactive exposure. This paper describes and discusses primarily the computer and control processes for the system.

  16. Controlled Vocabulary Service Application for Environmental Data Store

    Science.gov (United States)

    Ji, P.; Piasecki, M.; Lovell, R.

    2013-12-01

    In this paper we present a controlled vocabulary service application for Environmental Data Store (EDS). The purpose for such application is to help researchers and investigators to archive, manage, share, search, and retrieve data efficiently in EDS. The Simple Knowledge Organization System (SKOS) is used in the application for the representation of the controlled vocabularies coming from EDS. The controlled vocabularies of EDS are created by collecting, comparing, choosing and merging controlled vocabularies, taxonomies and ontologies widely used and recognized in geoscience/environmental informatics community, such as Environment ontology (EnvO), Semantic Web for Earth and Environmental Terminology (SWEET) ontology, CUAHSI Hydrologic Ontology and ODM Controlled Vocabulary, National Environmental Methods Index (NEMI), National Water Information System (NWIS) codes, EPSG Geodetic Parameter Data Set, WQX domain value etc. TemaTres, an open-source, web -based thesaurus management package is employed and extended to create and manage controlled vocabularies of EDS in the application. TemaTresView and VisualVocabulary that work well with TemaTres, are also integrated in the application to provide tree view and graphical view of the structure of vocabularies. The Open Source Edition of Virtuoso Universal Server is set up to provide a Web interface to make SPARQL queries against controlled vocabularies hosted on the Environmental Data Store. The replicas of some of the key vocabularies commonly used in the community, are also maintained as part of the application, such as General Multilingual Environmental Thesaurus (GEMET), NetCDF Climate and Forecast (CF) Standard Names, etc.. The application has now been deployed as an elementary and experimental prototype that provides management, search and download controlled vocabularies of EDS under SKOS framework.

  17. Thermotherapy on physiological and health quality of stored Jatropha seeds

    Directory of Open Access Journals (Sweden)

    Cristina Fernanda Schneider

    2015-02-01

    Full Text Available Among the many species that can be used to obtain vegetable oil for energy, Jatropha is considered one of the best options. Therefore, it is necessary to have seeds with good physiological and health quality in order to have a good establishment of plants in the field. This study aimed to evaluate the efficiency of heat treatment to the control of seed-borne pathogens in stored Jatropha seeds. The experimental design was completely randomized with a factorial 5x4 (five periods of storage x four treatment temperatures. The seeds of Jatropha were collected in Dourados - MS, and were subjected to processing and sun drying, and then stored in a dry chamber in glass flaskswith a screw cap and a capacity of 500 mL, for periods of 0, 90, 180, 270, and 360 days. After each storage period, seeds were subjected to thermotherapy by immersion in hot water at temperatures of 45°C, 50°C, and 55°C for 15 minutes; the control treatment was immersed in water at room temperature (25±2°C for 15 minutes. The parameters evaluated were: moisture content, germinations, germination speed index, electrical conductivity and health. Heat treatment at temperatures of 45°C, 50°C and 55°C don’t affect germination and the cell membrane integrity of the seed. After 180 days the use of thermotherapy contributed to the conservation of seed vigor. The fungus Penicillium sp. and Acremonium sp. are eliminated by thermotherapy at temperatures of 45°C, 50°C and 55°C, and Aspergillus sp. is controlled at a temperature of 55°C in periods of storage of 180 and 270 days.

  18. Polarizing a stored proton beam by spin-flip?

    Energy Technology Data Exchange (ETDEWEB)

    Oellers, Dieter Gerd Christian

    2010-04-15

    The present thesis discusses the extraction of the electron-proton spin-flip cross-section. The experimental setup, the data analysis and the results are pictured in detail. The proton is described by a QCD-based parton model. In leading twist three functions are needed. The quark distribution, the helicity distribution and the transversity distribution. While the first two are well-known, the transversity distribution is largely unknown. A self-sufficient measurement of the transversity is possible in double polarized proton-antiproton scattering. This rises the need of a polarized antiproton beam. So far spin filtering is the only tested method to produce a polarized proton beam, which may be capable to hold also for antiprotons. In-situ polarization build-up of a stored beam either by selective removal or by spin-flip of a spin-(1)/(2) beam is mathematically described. A high spin-flip cross-section would create an effective method to produce a polarized antiproton beam by polarized positrons. Prompted by conflicting calculations, a measurement of the spin-flip cross-section in low-energy electron-proton scattering was carried out. This experiment uses the electron beam of the electron cooler at COSY as an electron target. The depolarization of the stored proton beam is detected. An overview of the experiment is followed by detailed descriptions of the cycle setup, of the electron target and the ANKE silicon tracking telescopes acting as a beam polarimeter. Elastic protondeuteron scattering is the analyzing reaction. The event selection is depicted and the beam polarization is calculated. Upper limits of the two electron-proton spin-flip cross-sections {sigma} {sub parallel} and {sigma} {sub perpendicular} {sub to} are deduced using the likelihood method. (orig.)

  19. Store Separation Testing Techniques at the Arnold Engineering Development Center. Volume 2. Description of Captive Trajectory Store Separation Testing in the Aerodynamic Wind Tunnel (4T)

    Science.gov (United States)

    1980-06-01

    matrix(1) Pitch and yaw incidence angles of the store longitudinal axis at carriage with respect to the aircraft longitudinal axis, positive nose up and...Coordinate Directions Origin Parallel to the aircraft longitudinal axis at store release and at constant angular orientation with respect to the

  20. Investigating the Effect of Social Stimulants of Store Atmosphere on Buyer Extra-role Behavior A Study of Refah Chain Stores

    Directory of Open Access Journals (Sweden)

    Fereshteh Mansouri

    2014-09-01

    Full Text Available Nowadays, it is impossible for retailers to establish a competitive and successful store Atmosphere in the marketplace via making a distinction in the outer facades of their stores, altering the pricing system, and diversifying the products offered in the store, due to the intense competition emerged in retailing markets. In addition to the economic effect on buyers’ behavior, the stores should try their best to attain their goals by less costing. Furthermore, as retailers can change the buyers’ behavior to the extra-role behavior, they can attain more appropriate goals. The social stimulants of store Atmosphere is one of the most important and effective factors on buyers’ behavior at shopping place. So, In this research We’ve connected these variables according to the different studies and designed our model. The statistical society of this study is customers of Refah chain stores in Tehran and The number of sample is 413 people that they were in sore. Validity of questionnaire was calculated based on opinions of university professors, vendors and also through factor analysis. We’ve also used Coefficient alpha (Cronbach, 87 percent and split half (83 percent for getting the reliability(83 percent. According to the results, it was confirmed that Social Stimulants of store atmosphere in Refah chain stores have effect on emotional-cognitive indicators and at a result, they have effect on buyer extra role behavior and this effect is not affected by buyers gender and age

  1. Can a virtual supermarket bring realism into the lab? Comparing shopping behavior using virtual and pictorial store representations to behavior in a physical store

    NARCIS (Netherlands)

    Herpen, van Erica; Broek, van den Eva; Trijp, van Hans C.M.; Yu, Tian

    2016-01-01

    Immersive virtual reality techniques present new opportunities for research into consumer behavior. The current study examines whether the increased realism of a virtual store compared to pictorial (2D) stimuli elicits consumer behavior that is more in line with behavior in a physical store. We exam

  2. User's demography and expectation regarding search, purchase and evaluation in mobile application store.

    Science.gov (United States)

    Prata, Wilson; de Moraes, Anamaria; Quaresma, Manuela

    2012-01-01

    This article is result from a questionnaire about mobile app store usage. The objective of this work was to collect information about user needs and opinion regarding search, purchase and evaluation process in Android Market, Apple App Store, BlackBerry App World and Nokia Ovi Store. The data collected was analyzed to identify the positive and negative usability aspects, if the process to perform these task are any different in those stores and if the users are satisfy with their store or if they have any complains about it. Its covers the brazilian market only.

  3. INFORMATION FOR THE USERS OF THE SELF-SERVICE STORES ON THE MEYRIN & PREVESSIN SITES

    CERN Multimedia

    Logistics Group

    2001-01-01

    In accordance with the Management Board's decision to rationalise the two self-service stores on the Meyrin and Prévessin sites, the users of these stores are hereby informed of the new arrangements. As of 2nd July 2001, the self-service stores will open on a half-time basis, i.e.: MEYRIN SITE SELF-SERVICE STORE (BUILDING 113) 9.00 a.m. to 12.00 midday PREVESSIN SITE SELF-SERVICE STORE (BUILDING 904) 2.30 p.m. to 4.30 p.m.

  4. INFORMATION FOR THE USERS OF THE SELF-SERVICES STORES ON THE MEYRIN AND PREVESSIN SITES

    CERN Multimedia

    Logistics Group

    2001-01-01

    In accordance with the Management Board's decision to rationalise the two self-service stores on the Meyrin and Prévessin sites, the users of these stores are hereby informed of the new arrangements. As of 2nd July 2001, the self-service stores will open on a half-time basis, i.e.: MEYRIN SITE SELF-SERVICE STORE (BUILDING 113) 9.00 a.m. to 12.00 midday PREVESSIN SITE SELF-SERVICE STORE (BUILDING 904) 2.30 p.m. to 4.30 p.m.

  5. Sensitivity of terpene emissions to drought and fertilization in terpene-storing Pinus halepensis and non-storing Quercus ilex.

    Science.gov (United States)

    Blanch, Josep-Salvador; Peñuelas, Josep; Llusià, Joan

    2007-10-01

    We studied the effects of water stress, fertilization and time course on foliar volatile terpene emission rates by Quercus ilex and Pinus halepensis in a garden experiment. The terpenes mostly emitted by both species were alpha-pinene, beta-pinene, beta-myrcene and Delta(3)-carene. P. halepensis emission rates (average 31.45 microg g(-1) DM h(-1)) were similar to those of Q. ilex (average 31.71 microg g(-1) DM h(-1)). The effects of drought (reduction to one-third of full watering) and fertilization (250 kg N ha(-1), 250 kg P ha(-1), or both) were different depending on the species: the drought treatment significantly increased the terpene emissions from Q. ilex by 33%, and the fertilization treatments reduced the terpene emissions from P. halepensis by 38%. Terpene emission rates increased with time course in parallel to raising summer temperatures in P. halepensis and Q. ilex, whose emission rates were temperature related (r = 0.42 and r = 0.68, respectively) and light related (r = 0.32 and r = 0.57, respectively). There was a positive relationship for P. halepensis, and a negative relationship for Q. ilex, between emission rates and relative water contents. No relationship was found between emission rates and N or P foliar concentrations. The results of this study show complex species-specific responses with stronger and faster short-term responses in terpene-non-storing than in storing species and indicate that terpene emissions may significantly change in the warmer, drier and more fertilized conditions predicted for the next decades in the Mediterranean region.

  6. CDAO-Store: Ontology-driven Data Integration for Phylogenetic Analysis

    Directory of Open Access Journals (Sweden)

    Son Tran

    2011-04-01

    Full Text Available Abstract Background The Comparative Data Analysis Ontology (CDAO is an ontology developed, as part of the EvoInfo and EvoIO groups supported by the National Evolutionary Synthesis Center, to provide semantic descriptions of data and transformations commonly found in the domain of phylogenetic analysis. The core concepts of the ontology enable the description of phylogenetic trees and associated character data matrices. Results Using CDAO as the semantic back-end, we developed a triple-store, named CDAO-Store. CDAO-Store is a RDF-based store of phylogenetic data, including a complete import of TreeBASE. CDAO-Store provides a programmatic interface, in the form of web services, and a web-based front-end, to perform both user-defined as well as domain-specific queries; domain-specific queries include search for nearest common ancestors, minimum spanning clades, filter multiple trees in the store by size, author, taxa, tree identifier, algorithm or method. In addition, CDAO-Store provides a visualization front-end, called CDAO-Explorer, which can be used to view both character data matrices and trees extracted from the CDAO-Store. CDAO-Store provides import capabilities, enabling the addition of new data to the triple-store; files in PHYLIP, MEGA, nexml, and NEXUS formats can be imported and their CDAO representations added to the triple-store. Conclusions CDAO-Store is made up of a versatile and integrated set of tools to support phylogenetic analysis. To the best of our knowledge, CDAO-Store is the first semantically-aware repository of phylogenetic data with domain-specific querying capabilities. The portal to CDAO-Store is available at http://www.cs.nmsu.edu/~cdaostore.

  7. O2 store management in diving emperor penguins.

    Science.gov (United States)

    Ponganis, P J; Stockard, T K; Meir, J U; Williams, C L; Ponganis, K V; Howard, R

    2009-01-01

    In order to further define O(2) store utilization during dives and understand the physiological basis of the aerobic dive limit (ADL, dive duration associated with the onset of post-dive blood lactate accumulation), emperor penguins (Aptenodytes forsteri) were equipped with either a blood partial pressure of oxygen (P(O(2))) recorder or a blood sampler while they were diving at an isolated dive hole in the sea ice of McMurdo Sound, Antarctica. Arterial P(O(2)) profiles (57 dives) revealed that (a) pre-dive P(O(2)) was greater than that at rest, (b) P(O(2)) transiently increased during descent and (c) post-dive P(O(2)) reached that at rest in 1.92+/-1.89 min (N=53). Venous P(O(2)) profiles (130 dives) revealed that (a) pre-dive venous P(O(2)) was greater than that at rest prior to 61% of dives, (b) in 90% of dives venous P(O(2)) transiently increased with a mean maximum P(O(2)) of 53+/-18 mmHg and a mean increase in P(O(2)) of 11+/-12 mmHg, (c) in 78% of dives, this peak venous P(O(2)) occurred within the first 3 min, and (d) post-dive venous P(O(2)) reached that at rest within 2.23+/-2.64 min (N=84). Arterial and venous P(O(2)) values in blood samples collected 1-3 min into dives were greater than or near to the respective values at rest. Blood lactate concentration was less than 2 mmol l(-1) as far as 10.5 min into dives, well beyond the known ADL of 5.6 min. Mean arterial and venous P(N(2)) of samples collected at 20-37 m depth were 2.5 times those at the surface, both being 2.1+/-0.7 atmospheres absolute (ATA; N=3 each), and were not significantly different. These findings are consistent with the maintenance of gas exchange during dives (elevated arterial and venous P(O(2)) and P(N(2)) during dives), muscle ischemia during dives (elevated venous P(O(2)), lack of lactate washout into blood during dives), and arterio-venous shunting of blood both during the surface period (venous P(O(2)) greater than that at rest) and during dives (arterialized venous P(O(2

  8. Fjernsynet som shaman: Om store mediebegivenheders transformative virkninger

    Directory of Open Access Journals (Sweden)

    Daniel Dayan

    1988-08-01

    Full Text Available Den direkte transmission af levende begivenheder har altid været TV- mediets særlige styrke, hvad enten det drejer sig om fodboldkampe, Lørdagskanalen eller kongebrylluper. Medieforskerne har da også interesseret sig for fjernsynets formidling af sportsbegivenheder og der er blevet lavet analyser af Kanaludsendelserne. Men hverken i Danmark eller andre steder har forskerne fundet det interessant at undersøge de store, ceremonielle mediebegivenheder. Det er Dayan & Katz´ projekt at udfylde dette tomrum i medie- og kul- turforskningen: Hvad er det, der fascinerer millioner ved disse TV- ceremonier, der ofte ikke blot henvender sig til et enkelt lands seere, men transmitteres til og ses af store dele af verden? Hvordan fungere disse begivenheder - hvad enten det drejer sig om Præsident Kennedys begravelse, Sadats besøg i Jerusalem, Månelandingen eller Watergate- høringerne - ideologisk, og hvilke interesser tjener de dermed i den politiske offentlighed? I denne artikel, der er et bearbejdet uddrag af den bog, projektet skal munde ud i, beskæftiger Dayan & Katz sig især med det de kalder "transformative" mediebegivenheder, dvs. TV-ceremonier der markerer, at et samfund står ved en tærskel mellem den herskende orden og en ny mulig orden, og som selv er et aktivt og aktiverende bidrag til forvand- lingen af kulturelle opfattelser og værdier. Artiklens perpektiv er udpræget tværvidenskabeligt, idet der trækkes på såvel kulturantropologiske (Levi-Strauss, Geertz, Turner som filosofiske (Bakhtin, Baudrillard, sprogteoretiske (Austin og traditionelt samfunds- videnskabelige/mediesociologiske (Boorstin arbejder. I artiklens første halvdel foretages der en afgrænsning af transformative over for andre ceremonielle begivenheder. I anden halvdel gennemgås de fem faser, som udgør transformative begivenheders typiske struktur. Artiklen er bearbejdet af Jørgen Bang og Kim Schrøder. Den er oversat af Kim Schrøder.

  9. Filling, storing and draining. Three key aspects of landslide hydrology

    Science.gov (United States)

    Bogaard, Thom; Greco, Roberto

    2016-04-01

    Rainfall-triggered landslides are among the most widespread hazards in the world. The hydrology in and around a landslide area is key to pore pressure build-up in the soil skeleton which reduces shear strength due to the buoyancy force exerted by water in a saturated soil and to soil suction in an unsaturated soil. Extraordinary precipitation events trigger most of the landslides, but, at the same time, the vast majority of slopes do not fail. The intriguing question is: 'When and where exactly can a slope become triggered to slide and flow downwards?' The objective of this article is to present and discuss landslide hydrology at three scales - pore, hillslope, and catchment - which, taken together, give an overview of this interdisciplinary science. In fact, for rainfall-triggered landslides to occur, an unfavourable hydrological interplay should exist between fast and/or prolonged infiltration, and a relatively 'slow' drainage. The competition of water storage, pressure build-up and the subsequently induced drainage contains the importance of the timing, which is indisputably one of the more delicate but relevant aspects of landslide modelling, the overlay of hydrological processes with different time scales. As slopes generally remain stable, we can argue that effective drainage mechanisms spontaneously develop, as the best for a slope to stay stable is getting rid of the overload of water (above field capacity), either vertically or laterally. So, landslide hydrology could be framed as 'Filling-Storing-Draining'. Obviously, 'Storing' is added to stress the importance of dynamic pressure build-up for slope stability. 'Draining' includes all removal of water from the system (vertical and lateral flow, evaporation and transpiration) and thus pore water pressure release. Furthermore, by addressing landslide hydrology from both earth sciences and soil mechanics perspectives, we aim to manifest the hydrological processes in hillslopes and their influence on behaviour

  10. Time-dependent histamine release from stored human blood products

    DEFF Research Database (Denmark)

    Nielsen, Hans Jørgen; Edvardsen, L; Vangsgaard, K;

    1996-01-01

    storage. Whole blood (six units), plasma-reduced whole blood (six units), and plasma- and buffy coat-reduced (saline-adenine-glucose-mannitol) (SAGM) blood (six units) from unpaid healthy donors were stored in the blood bank for 35 days at 4 degrees C. Plasma histamine and total cell-bound histamine......Perioperative transfusion of whole blood has been shown to amplify trauma-induced immunosuppression, which could be attenuated by perioperative administration of histamine2 receptor antagonists. Supernatants from different blood products were, therefore, analysed for histamine content during.......0 (range 176.0-910.0) nmol/l in whole blood and 475.0 (range 360.0-1560.0) nmol/l in plasma-reduced whole blood, while it was undetectable in SAGM blood. Spontaneous histamine release increased in a time-dependent manner from a median of 6.7 (range 2.2-17.4) nmol/l at the time of storage to 175.0 (range 33...

  11. ReStore: Reusing Results of MapReduce Jobs

    CERN Document Server

    Elghandour, Iman

    2012-01-01

    Analyzing large scale data has emerged as an important activity for many organizations in the past few years. This large scale data analysis is facilitated by the MapReduce programming and execution model and its implementations, most notably Hadoop. Users of MapReduce often have analysis tasks that are too complex to express as individual MapReduce jobs. Instead, they use high-level query languages such as Pig, Hive, or Jaql to express their complex tasks. The compilers of these languages translate queries into workflows of MapReduce jobs. Each job in these workflows reads its input from the distributed file system used by the MapReduce system and produces output that is stored in this distributed file system and read as input by the next job in the workflow. The current practice is to delete these intermediate results from the distributed file system at the end of executing the workflow. One way to improve the performance of workflows of MapReduce jobs is to keep these intermediate results and reuse them fo...

  12. Participatory ergonomics among female cashiers from a department store.

    Science.gov (United States)

    Cristancho, María Yanire León

    2012-01-01

    The objective of this paper was to control ergonomic risks among female cashiers working in a department store belonging to the retail market. This study was conducted between May and November 2010. Participatory ergonomics was applied through knowing and understanding how the company works, establishing the work team (Ergo group), training the team in ergonomics-related topics, and making decisions and interventions. The sample was composed of 71 participants--mostly female cashiers--, and all of them have a musculoskeletal compromise, declaring pain or discomfort mainly in the neck, lower back, right wrist and shoulders. Among others, following problems were found: postural overload, repetitive work, manual load handling, mental fatigue, environmental discomfort, variable work schedules, extended working days, and absence of breaks. In the intervention, the main implemented changes were the redesign of workstation, complete change of chairs and keyboards, and the implementation of a rotation system, as well breaks for compensatory exercises. After that, an evident improvement of found problems was observed, therefore it can be concluded that participatory ergonomics is an attractive methodology, appropriate and efficient for solving and controlling ergonomic risks and problems.

  13. Plant compounds insecticide activity against Coleoptera pests of stored products

    Energy Technology Data Exchange (ETDEWEB)

    Moreira, Marcio Dionizio; Picanco, Marcelo Coutinho; Guedes, Raul Narciso Carvalho; Campos, Mateus Ribeiro de; Silva, Gerson Adriano; Martins, Julio Claudio [Universidade Federal de Vicosa (UFV), MG (Brazil). Dept. de Biologia Animal]. E-mail: marcio.dionizio@gmail.com; picanco@ufv.br; guedes@ufv.br; mateusc3@yahoo.com.br; agronomiasilva@yahoo.com.br

    2007-07-15

    The objective of this work was to screen plants with insecticide activity, in order to isolate, identify and assess the bioactivity of insecticide compounds present in these plants, against Coleoptera pests of stored products: Oryzaephilus surinamensis L. (Silvanidae), Rhyzopertha dominica F. (Bostrichidae) and Sitophilus zeamais Mots. (Curculionidae). The plant species used were: basil (Ocimum selloi Benth.), rue (Ruta graveolens L.), lion's ear (Leonotis nepetifolia (L.) R.Br.), jimson weed (Datura stramonium L.), baleeira herb (Cordia verbenacea L.), mint (Mentha piperita L.), wild balsam apple (Mormodica charantia L.), and billy goat weed or mentrasto (Ageratum conyzoides L.). The insecticide activity of hexane and ethanol extracts from those plants on R. dominica was evaluated. Among them, only hexane extract of A. conyzoides showed insecticide activity; the hexane extract of this species was successively fractionated by silica gel column chromatography, for isolation and purification of the active compounds. Compounds 5,6,7,8,3',4',5'-heptamethoxyflavone; 5,6,7,8,3'-pentamethoxy-4',5'-methilenedioxyflavone and coumarin were identified. However, only coumarin showed insecticide activity against three insect pests (LD{sub 50} from 2.72 to 39.71 mg g{sup -1} a.i.). The increasing order of insects susceptibility to coumarin was R. dominica, S. zeamais and O. surinamensis. (author)

  14. Temperature environment for 9975 packages stored in KAC

    Energy Technology Data Exchange (ETDEWEB)

    Daugherty, W. L. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-09-10

    Plutonium materials are stored in the K Area Complex (KAC) in shipping packages, typically the 9975 shipping package. In order to estimate realistic degradation rates for components within the shipping package (i.e. the fiberboard overpack and O-ring seals), it is necessary to understand actual facility temperatures, which can vary daily and seasonally. Relevant facility temperature data available from several periods throughout its operating history have been reviewed. The annual average temperature within the Crane Maintenance Area has ranged from approximately 70 to 74 °F, although there is significant seasonal variation and lesser variation among different locations within the facility. The long-term average degradation rate for 9975 package components is very close to that expected if the component were to remain continually at the annual average temperature. This result remains valid for a wide range of activation energies (which describes the variation in degradation rate as the temperature changes), if the activation energy remains constant over the seasonal range of component temperatures. It is recommended that component degradation analyses and service life estimates incorporate these results. Specifically, it is proposed that future analyses assume an average facility ambient air temperature of 94 °F. This value is bounding for all packages, and includes margin for several factors such as increased temperatures within the storage arrays, the addition of more packages in the future, and future operational changes.

  15. Type of dietary lipids and storing time on egg stability

    Directory of Open Access Journals (Sweden)

    Ana Lúcia Fernandes Pereira

    2011-12-01

    Full Text Available The objective of this work was to evaluate the influence of diets containing different lipid sources on eggs quality during refrigerated storage, on yolk fatty acid composition, and on cholesterol in the yolk. Four diets were used containing Soy Oil (SO, Sunflower Seed (SS, and Meat and Bone Meal + Soy Oil (MBM + SO or Meat and Bone Meal + Tallow (MBM + TA. The experiment followed a factorial design 4 × 3 with four dietary treatments and three storage times. The eggs were stored at 4 °C for 0, 30, and 60 days. The collected eggs were analyzed for egg weight loss, Haugh units, yolk moisture, yolk lipid oxidation, and cooked yolk firmness. Refrigerated storage reduced Haugh units, and increased yolk moisture. Sixty days of storage time reduced the firmness of hard-cooked yolk. There was an interaction between dietary treatment and storage time for egg weight loss and lipid oxidation. With regard to yolk fatty acid profile, MBM + TA diet increased the contents of palmitic and palmitoleic acids. The levels of oleic and arachidonic acids were higher in yolks from birds fed with SS diet. Linoleic acid level was higher in the yolk from treatment with SO diet. Diets containing MBM + SO induced higher levels of docosahexaenoic acid. Yolk cholesterol content was reduced with the inclusion of SS in the diet. Therefore, the type of lipid present in the diet and refrigerated storage for 60 days at 4 °C can affect the egg quality.

  16. Study of doubly strange systems using stored antiprotons

    Science.gov (United States)

    Singh, B.; Erni, W.; Krusche, B.; Steinacher, M.; Walford, N.; Liu, B.; Liu, H.; Liu, Z.; Shen, X.; Wang, C.; Zhao, J.; Albrecht, M.; Erlen, T.; Fink, M.; Heinsius, F.; Held, T.; Holtmann, T.; Jasper, S.; Keshk, I.; Koch, H.; Kopf, B.; Kuhlmann, M.; Kümmel, M.; Leiber, S.; Mikirtychyants, M.; Musiol, P.; Mustafa, A.; Pelizäus, M.; Pychy, J.; Richter, M.; Schnier, C.; Schröder, T.; Sowa, C.; Steinke, M.; Triffterer, T.; Wiedner, U.; Ball, M.; Beck, R.; Hammann, C.; Ketzer, B.; Kube, M.; Mahlberg, P.; Rossbach, M.; Schmidt, C.; Schmitz, R.; Thoma, U.; Urban, M.; Walther, D.; Wendel, C.; Wilson, A.; Bianconi, A.; Bragadireanu, M.; Caprini, M.; Pantea, D.; Patel, B.; Czyzycki, W.; Domagala, M.; Filo, G.; Jaworowski, J.; Krawczyk, M.; Lisowski, E.; Lisowski, F.; Michałek, M.; Poznański, P.; Płażek, J.; Korcyl, K.; Kozela, A.; Kulessa, P.; Lebiedowicz, P.; Pysz, K.; Schäfer, W.; Szczurek, A.; Fiutowski, T.; Idzik, M.; Mindur, B.; Przyborowski, D.; Swientek, K.; Biernat, J.; Kamys, B.; Kistryn, S.; Korcyl, G.; Krzemien, W.; Magiera, A.; Moskal, P.; Psyzniak, A.; Rudy, Z.; Salabura, P.; Smyrski, J.; Strzempek, P.; Wronska, A.; Augustin, I.; Böhm, R.; Lehmann, I.; Nicmorus Marinescu, D.; Schmitt, L.; Varentsov, V.; Al-Turany, M.; Belias, A.; Deppe, H.; Dzhygadlo, R.; Ehret, A.; Flemming, H.; Gerhardt, A.; Götzen, K.; Gromliuk, A.; Gruber, L.; Karabowicz, R.; Kliemt, R.; Krebs, M.; Kurilla, U.; Lehmann, D.; Löchner, S.; Lühning, J.; Lynen, U.; Orth, H.; Patsyuk, M.; Peters, K.; Saito, T.; Schepers, G.; Schmidt, C. J.; Schwarz, C.; Schwiening, J.; Täschner, A.; Traxler, M.; Ugur, C.; Voss, B.; Wieczorek, P.; Wilms, A.; Zühlsdorf, M.; Abazov, V. M.; Alexeev, G.; Arefiev, A.; Astakhov, V. I.; Barabanov, M. Yu.; Batyunya, B. V.; Davydov, Yu. I.; Dodokhov, V. Kh.; Efremov, A. A.; Fechtchenko, A.; Fedunov, A. G.; Galoyan, A.; Grigoryan, S.; Koshurnikov, E. K.; Lobanov, V. I.; Lobanov, Y. Yu.; Makarov, A. F.; Malinina, L. V.; Malyshev, V. L.; Olshevskiy, A.; Perevalova, E.; Piskun, A. A.; Pocheptsov, T.; Pontecorvo, G.; Rodionov, V.; Rogov, Y.; Salmin, R.; Samartsev, A.; Sapozhnikov, M. G.; Shabratova, G.; Skachkov, N. B.; Skachkova, A. N.; Strokovsky, E. A.; Suleimanov, M.; Teshev, R.; Tokmenin, V.; Uzhinsky, V.; Vodopyanov, A.; Zaporozhets, S. A.; Zhuravlev, N. I.; Zorin, A. G.; Branford, D.; Glazier, D.; Watts, D.; Böhm, M.; Britting, A.; Eyrich, W.; Lehmann, A.; Pfaffinger, M.; Uhlig, F.; Dobbs, S.; Seth, K.; Tomaradze, A.; Xiao, T.; Bettoni, D.; Carassiti, V.; Cotta Ramusino, A.; Dalpiaz, P.; Drago, A.; Fioravanti, E.; Garzia, I.; Savriè, M.; Akishina, V.; Kisel, I.; Kozlov, G.; Pugach, M.; Zyzak, M.; Gianotti, P.; Guaraldo, C.; Lucherini, V.; Bersani, A.; Bracco, G.; Macri, M.; Parodi, R. F.; Biguenko, K.; Brinkmann, K.; Di Pietro, V.; Diehl, S.; Dormenev, V.; Drexler, P.; Düren, M.; Etzelmüller, E.; Galuska, M.; Gutz, E.; Hahn, C.; Hayrapetyan, A.; Kesselkaul, M.; Kühn, W.; Kuske, T.; Lange, J. S.; Liang, Y.; Metag, V.; Nanova, M.; Nazarenko, S.; Novotny, R.; Quagli, T.; Reiter, S.; Rieke, J.; Rosenbaum, C.; Schmidt, M.; Schnell, R.; Stenzel, H.; Thöring, U.; Ullrich, M.; Wagner, M. N.; Wasem, T.; Wohlfarth, B.; Zaunick, H.; Ireland, D.; Rosner, G.; Seitz, B.; Deepak, P. N.; Kulkarni, A.; Apostolou, A.; Babai, M.; Kavatsyuk, M.; Lemmens, P.; Lindemulder, M.; Loehner, H.; Messchendorp, J.; Schakel, P.; Smit, H.; Tiemens, M.; van der Weele, J. C.; Veenstra, R.; Vejdani, S.; Dutta, K.; Kalita, K.; Kumar, A.; Roy, A.; Sohlbach, H.; Bai, M.; Bianchi, L.; Büscher, M.; Cao, L.; Cebulla, A.; Dosdall, R.; Gillitzer, A.; Goldenbaum, F.; Grunwald, D.; Herten, A.; Hu, Q.; Kemmerling, G.; Kleines, H.; Lehrach, A.; Nellen, R.; Ohm, H.; Orfanitski, S.; Prasuhn, D.; Prencipe, E.; Pütz, J.; Ritman, J.; Schadmand, S.; Sefzick, T.; Serdyuk, V.; Sterzenbach, G.; Stockmanns, T.; Wintz, P.; Wüstner, P.; Xu, H.; Zambanini, A.; Li, S.; Li, Z.; Sun, Z.; Xu, H.; Rigato, V.; Isaksson, L.; Achenbach, P.; Corell, O.; Denig, A.; Distler, M.; Hoek, M.; Karavdina, A.; Lauth, W.; Liu, Z.; Merkel, H.; Müller, U.; Pochodzalla, J.; Schlimme, S.; Sfienti, C.; Thiel, M.; Ahmadi, H.; Ahmed, S.; Bleser, S.; Capozza, L.; Cardinali, M.; Dbeyssi, A.; Deiseroth, M.; Feldbauer, F.; Fritsch, M.; Fröhlich, B.; Jasinski, P.; Kang, D.; Khaneft, D.; Klasen, R.; Leithoff, H. H.; Lin, D.; Maas, F.; Maldaner, S.; Martìnez Rojo, M.; Marta, M.; Michel, M.; Mora Espì, M. C.; Morales Morales, C.; Motzko, C.; Nerling, F.; Noll, O.; Pflüger, S.; Pitka, A.; Rodríguez Piñeiro, D.; Sanchez Lorente, A.; Steinen, M.; Valente, R.; Weber, T.; Zambrana, M.; Zimmermann, I.; Fedorov, A.; Korjik, M.; Missevitch, O.; Boukharov, A.; Malyshev, O.; Marishev, I.; Balanutsa, P.; Balanutsa, V.; Chernetsky, V.; Demekhin, A.; Dolgolenko, A.; Fedorets, P.; Gerasimov, A.

    2016-10-01

    Bound nuclear systems with two units of strangeness are still poorly known despite their importance for many strong interaction phenomena. Stored antiprotons beams in the GeV range represent an unparalleled factory for various hyperon-antihyperon pairs. Their outstanding large production probability in antiproton collisions will open the floodgates for a series of new studies of systems which contain two or even more units of strangeness at the P ‾ ANDA experiment at FAIR. For the first time, high resolution γ-spectroscopy of doubly strange ΛΛ-hypernuclei will be performed, thus complementing measurements of ground state decays of ΛΛ-hypernuclei at J-PARC or possible decays of particle unstable hypernuclei in heavy ion reactions. High resolution spectroscopy of multistrange Ξ--atoms will be feasible and even the production of Ω--atoms will be within reach. The latter might open the door to the | S | = 3 world in strangeness nuclear physics, by the study of the hadronic Ω--nucleus interaction. For the first time it will be possible to study the behavior of Ξ‾+ in nuclear systems under well controlled conditions.

  17. Repetitive energy transfer from an inductive energy store

    Energy Technology Data Exchange (ETDEWEB)

    Honig, E.M.

    1984-01-01

    The theoretical and experimental results of a research program aimed at finding practical ways to transfer energy repetitively from an inductive energy store to various loads are discussed. The objectives were to investigate and develop the high power opening switches and transfer circuits needed to enable high-repetition-rate operation of such systems, including a feasibility demonstration at a current level near 10 kA and a pulse repetition rate of 1-10 kpps with a 1-ohm load. The requirements of nonlinear, time-varying loads, such as the railgun electromagnetic launcher, were also addressed. Energy storage capability is needed for proper power conditioning in systems where the duty factor of the output pulse train is low. Inductive energy storage is attractive because it has both a high energy storage density and a fast discharge capability. By producing a pulse train with a peak power of 75 MW at a pulse repetition rate of 5 kpps in a one-ohm load system, this research program was the first to demonstrate fully-controlled, high-power, high-repetition-rate operation of an inductive energy storage and transfer system with survivable switches. Success was made possible by using triggered vacuum gap switches as repetitive, current-zero opening switches and developing several new repetitive transfer circuits using the counterpulse technique.

  18. A database for storing the results of material radiopurity measurements

    Science.gov (United States)

    Loach, J. C.; Cooley, J.; Cox, G. A.; Li, Z.; Nguyen, K. D.; Poon, A. W. P.

    2016-12-01

    Searches for rare nuclear processes, such as neutrinoless double beta-decay and the interactions of WIMP dark matter, are motivating experiments with ever-decreasing levels of radioactive backgrounds. These background reductions are achieved using various techniques, but amongst the most important is minimizing radioactive contamination in the materials from which the experiment is constructed. To this end there have been decades of advances in material sourcing, manufacture and certification, during which researchers have accumulated many thousands of measurements of material radiopurity. Some of these assays are described in publications, others are in databases, but many are still communicated informally. Until this work, there has been no standard format for encoding assay results and no effective, central location for storing them. The aim of this work is to address these long-standing problems by creating a concise and flexible material assay data format and powerful software application to manipulate it. A public installation of this software, available at http://www.radiopurity.org, is the largest database of assay results ever compiled and is intended as a long-term repository for the community's data.

  19. Horizontally Differentiated Store Brands: Production Outsourcing to National Brand Manufacturers

    Directory of Open Access Journals (Sweden)

    Shun Shindo

    2014-01-01

    Full Text Available We study a retailer's strategic decision with regard to outsourcing the production of such types of store brands (SBs to national brand (NB manufacturers. The wholesale price of NB is assumed to be set by the manufacturer, while that of the SB is assumed to be set by the retailer. When a retailer outsources SB production to an NB manufacturer, the NB manufacturer might suffer from cannibalization due to offering both the SB and the NB, implying that a strategic interaction between the retailer and manufacturer is an important issue. Based on this motivation, we mainly focus on the strategy of a dominant retailer in such a situation and investigate it with a game-theoretic approach. We show that the optimal strategy for the SB retailer sensitively depends on the degree of differentiation between the SB and the NB. In particular, if both products are less differentiated, the retailer benefits from offering only the SB, and, in this case, the retailer should offer its wholesale price, after the manufacturer sets the NB wholesale price. Furthermore, it is shown that the optimal strategies of the retailer are socially efficient, if and only if the SB and the NB are sufficiently differentiated.

  20. Thermal Analysis of ZPPR High Pu Content Stored Fuel

    Directory of Open Access Journals (Sweden)

    Charles W. Solbrig

    2014-01-01

    Full Text Available The Zero Power Physics Reactor (ZPPR operated from April 18, 1969, until 1990. ZPPR operated at low power for testing nuclear reactor designs. This paper examines the temperature of Pu content ZPPR fuel while it is in storage. Heat is generated in the fuel due to Pu and Am decay and is a concern for possible cladding damage. Damage to the cladding could lead to fuel hydriding and oxidizing. A series of computer simulations were made to determine the range of temperatures potentially occuring in the ZPPR fuel. The maximum calculated fuel temperature is 292°C (558°F. Conservative assumptions in the model intentionally overestimate temperatures. The stored fuel temperatures are dependent on the distribution of fuel in the surrounding storage compartments, the heat generation rate of the fuel, and the orientation of fuel. Direct fuel temperatures could not be measured but storage bin doors, storage sleeve doors, and storage canister temperatures were measured. Comparison of these three temperatures to the calculations indicates that the temperatures calculated with conservative assumptions are, as expected, higher than the actual temperatures. The maximum calculated fuel temperature with the most conservative assumptions is significantly below the fuel failure criterion of 600°C (1,112°F.

  1. Sodium and potassium changes in blood bank stored human erythrocytes.

    Science.gov (United States)

    Wallas, C H

    1979-01-01

    Storage of red cells for three weeks at 4 C under blood bank conditions resulted in a rise in intracellular Na+ and a fall in intracellular K+ with concomitant opposite changes in Na+ and K+ levels in the suspending plasma. A decline in red blood cell ATP during the storage period did not appear to be contributing to the changes. Increasing red blood cell ATP to levels 2 to 3 times normal did not prevent the cation changes from occurring. When assayed at 37 C in the presence of added Mg++, ouabain-sensitive membrane ATPase activity and kinetics of activation by Na+ were unaffected by the three week period of cold storage. However, when assayed at 4 C without added Mg++, simulating the conditions of storage, ATPase activity was negligible. Sodium and potassium did not change when red blood cells with normal ATP content were stored at 20 to 24 C even in the absence of added Mg++. Thus, a major cause for the development of cation changes in the red blood cell during blood bank storage in the temperature which inhibits membrane ATPase, allowing cations to leak unopposed into and out of the red blood cells.

  2. Neutrinos from Stored Muons (STORM): Expression of Interest

    CERN Document Server

    Adey, D; Agarwalla, SK; Asfandiyarov, R; Back, JJ; Barker, G; Baussan, E; Bayes, R; Bhadra, S; Booth, C; Blackmore, V; Blondel, A; Bogacz, SA; Boyd, SB; Bravar, A; Brice, SJ; Bross, AD; Cadoux, F; Cease, H; Cervera, A; Cobb, J; Colling, D; Coney, L; Dobbs, A; Dobson, J; Donini, A; Dornan, PJ; Dracos, M; Dufour, F; Edgecock, R; Evans, J; George, MA; Ghosh, T; deGouvea, A; Gomez-Cadenas, JJ; Haesler, A; Hanson, G; Harrison, PF; Hartz, M; Hernandez, P; Hernando-Morata, JA; Hodgson, PJ; Huber, P; Izmaylov, A; Karadhzov, Y; Kopp, J; Kormos, L; Korzenev, A; Kurup, A; Kuno, Y; Kyberd, P; Lagrange, JP; Laing, AM; Link, J; Liu, A; Long, KR; McCauley, N; McDonald, KT; Mahn, K; Martin, C; Martin, J; Mena, O; Mishra, SR; Mokhov, N; Morfin, J; Mori, Y; Murray, W; Neuffer, D; Nichol, R; Noah, E; Parke, S; Pascoli, S; Pasternak, J; Popovic, M; Ratoff, P; Ravonel, M; Rayner, M; Ricciardi, S; Rogers, C; Rubinov, P; Santos, E; Sato, A; Scantamburlo, E; Sedgbeer, JK; Smith, P; Smith, J; Sobczyk, JT; Soldner-Rembold, S; Soler, FJP; Sorel, M; Stamoulis, P; Striganov, S; Tanaka, H; Taylor, I; Touramanis, C; Tunnel, CD; Uchida, Y; Wascko, MO; Vassilopoulos, N; Weber, A; Wildner, E; Winter, W; Yang, UK; CERN. Geneva. SPS and PS Experiments Committee; SPSC

    2013-01-01

    The $ u$STORM facility has been designed to deliver beams of $ u_e$ and $ u_mu$ from the decay of a stored $mu^pm$ beam with a central momentum of 3.8 GeV/c and a momentum spread of 10%. The facility is unique in that it will: serve the future long- and short-baseline neutrino-oscillation programmes by providing definitive measurements of $ u_e N$ and $ u_mu N$ scattering cross sections with percent-level precision; allow searches for sterile neutrinos of exquisite sensitivity to be carried out; and constitute the essential first step in the incremental development of muon accelerators as a powerful new technique for particle physics. Of the world's proton-accelerator laboratories, only CERN and FNAL have the infrastructure required to mount $ u$STORM. In view of the fact that no siting decision has yet been taken, the purpose of this Expression of Interest (EoI) is to request the resources required to: investigate in detail how $ u$STORM could be implemented at CERN; and develop options for decisive European...

  3. Neutrinos from Stored Muons nuSTORM: Expression of Interest

    CERN Document Server

    Adey, D; Ankenbrandt, C M; Asfandiyarov, R; Back, J J; Barker, G; Baussan, E; Bayes, R; Bhadra, S; Blackmore, V; Blondel, A; Bogacz, S A; Booth, C; Boyd, S B; Bravar, A; Brice, S J; Bross, A D; Cadoux, F; Cease, H; Cervera, A; Cobb, J; Colling, D; Coney, L; Dobbs, A; Dobson, J; Donini, A; Dornan, P J; Dracos, M; Dufour, F; Edgecock, R; Evans, J; Geelhoed, M; George, M A; Ghosh, T; de Gouvea, A; Gomez-Cadenas, J J; Haesler, A; Hanson, G; Harrison, P F; Hartz, M; Hernandez, P; Hernando-Morata, J A; Hodgson, P J; Huber, P; Izmaylov, A; Karadhzov, Y; Kobilarcik, T; Kopp, J; Kormos, L; Korzenev, A; Kurup, A; Kuno, Y; Kyberd, P; Lagrange, J P; Laing, A M; Link, J; Liu, A; Long, K R; McCauley, N; McDonald, K T; Mahn, K; Martin, C; Martin, J; Mena, O; Mishra, S R; Mokhov, N; Morfin, J; Mori, Y; Murray, W; Neuffer, D; Nichol, R; Noah, E; Palmer, M A; Parke, S; Pascoli, S; Pasternak, J; Popovic, M; Ratoff, P; Ravonel, M; Rayner, M; Ricciardi, S; Rogers, C; Rubinov, P; Santos, E; Sato, A; Scantamburlo, E; Sedgbeer, J K; Smith, D R; Smith, P J; Sobczyk, J T; Soldner-Rembold, S; Soler, F J P; Sorel, M; Stahl, A; Stanco, L; Stamoulis, P; Striganov, S; Tanaka, H; Taylor, I J; Touramanis, C; Tunnell, C D; Uchida, Y; Vassilopoulos, N; Wascko, M O; Wilking, M J; Weber, A; Wildner, E; Winter, W; Yang, U K

    2013-01-01

    The nuSTORM facility has been designed to deliver beams of electron and muon neutrinos from the decay of a stored muon beam with a central momentum of 3.8 GeV/c and a momentum spread of 10%. The facility is unique in that it will: serve the future long- and short-baseline neutrino-oscillation programmes by providing definitive measurements of electron-neutrino- and muon-neutrino-nucleus cross sections with percent-level precision; allow searches for sterile neutrinos of exquisite sensitivity to be carried out; and constitute the essential first step in the incremental development of muon accelerators as a powerful new technique for particle physics. Of the world's proton-accelerator laboratories, only CERN and FNAL have the infrastructure required to mount nuSTORM. Since no siting decision has yet been taken, the purpose of this Expression of Interest (EoI) is to request the resources required to: investigate in detail how nuSTORM could be implemented at CERN; and develop options for decisive European contrib...

  4. The interference aerodynamics caused by the wing elasticity during store separation

    Science.gov (United States)

    Lei, Yang; Zheng-yin, Ye

    2016-04-01

    Air-launch-to-orbit is the technology that has stores carried aloft and launched the store from the plane to the orbit. The separation between the aircraft and store is one of the most important and difficult phases in air-launch-to-orbit technology. There exists strong aerodynamic interference between the aircraft and the store in store separation. When the aspect ratio of the aircraft is large, the elastic deformations of the wing must be considered. The main purpose of this article is to study the influence of the interference aerodynamics caused by the elastic deformations of the wing to the unsteady aerodynamics of the store. By solving the coupled functions of unsteady Navier-Stokes equations, six degrees of freedom dynamic equations and structural dynamic equations simultaneously, the store separation with the elastic deformation of the aircraft considered is simulated numerically. And the interactive aerodynamic forces are analyzed. The study shows that the interference aerodynamics is obvious at earlier time during the separation, and the dominant frequency of the elastic wing determines the aerodynamic forces frequencies of the store. Because of the effect of the interference aerodynamics, the roll angle response and pitch angle response increase. When the store is mounted under the wingtip, the additional aerodynamics caused by the wingtip vortex is obvious, which accelerate the divergence of the lateral force and the lateral-directional attitude angle of the store. This study supports some beneficial conclusions to the engineering application of the air-launch-to-orbit.

  5. WHAT MATTERS TO STORE BRAND EQUITY? AN APPROACH TO SPANISH LARGE RETAILING IN A DOWNTURN CONTEXT

    Directory of Open Access Journals (Sweden)

    Calvo-Porral, Cristina

    2013-09-01

    Full Text Available Store brands account for 41% of the Spanish market share in 2011, and a further increase is expected in next years due to economic crisis, which makes up an increasingly competitive market with great research interest. In this context, our study aims to analyze which variables have a relevant influence on store Brand Equity from the consumers’ standpoint in the current downturn context, providing an empirical research on the Spanish large retailing. We carried out an on-line questionnaire to customers of store brands residing in Spain, obtaining a total amount of 362 valid responses regarding the Spanish large retailers Mercadona, Dia, Eroski, Carrefour and El Corte Inglés. Then, the analysis was performed by Structural Equation Modeling (SEM. Results obtained suggest that store commercial image has the higher influence on both store brand perceived quality and store brand awareness, and in relation with the sources of store Brand Equity, the dimension store brand awareness shows the greater influence on the formation of store Brand Equity. This study is of great interest for large retailers who wish to increase their store brands’ value proposition to the marketplace, especially during economic downturns.

  6. Convenience stores surrounding urban schools: an assessment of healthy food availability, advertising, and product placement.

    Science.gov (United States)

    Gebauer, Hilary; Laska, Melissa Nelson

    2011-08-01

    Adolescent obesity is a national public health problem, particularly among urban populations. Recent evidence has linked neighborhood food environments to health and nutrition status, with easier access to convenience stores being associated with increased risk for obesity. Little is known about the availability of healthy purchasing options within small, urban food stores, or the extent to which these factors are relevant to youth. The objective of this research was to characterize various features of the food environment within small convenience stores located nearby urban junior high and high schools. In-store audits were conducted in 63 stores located within 800 m of 36 urban Minnesota public secondary schools. Results indicated that a limited number of healthier beverages (i.e., water and 100% fruit juice) and snack options (i.e., nuts and pretzels) were available at most stores (≥85%). However, a wide range of healthy snack options were typically not available, with many specific items stocked in less than half of stores (e.g., low-fat yogurt in 27% of stores and low-fat granola bars in 43%). Overall, 51% of stores had fresh fruit and 49% had fresh vegetables. Few stores carried a range of healthier snack alternatives in single-serving packages. All stores had less healthful impulse purchase items available (e.g., candy) while only 46% carried healthier impulse items (e.g., fruit). Most stores (97%) had food/beverage advertising. Overall, convenience stores located in close proximity to secondary schools represent an important and understudied component of the youth food environment.

  7. Differential distribution of calcium stores in paramecium cells. Occurrence of a subplasmalemmal store with a calsequestrin-like protein.

    Science.gov (United States)

    Plattner, H; Habermann, A; Kissmehl, R; Klauke, N; Majoul, I; Söling, H D

    1997-04-01

    We have analyzed in Paramecium cells the occurrence and intracellular distribution of the high capacity/low affinity calcium-binding proteins, calsequestrin (CS) and calreticulin (CR) using antibodies against CS from rat skeletal muscle and against CR from rat liver, respectively. As revealed by Western blots, a CS-like protein isolated by affinity chromatography from Paramecium cells comigrated with CS isolated from rat skeletal muscle. The immunoreactivity of this 53 kDa protein band was blocked when the antibodies had been preadsorbed with purified rat CS. A band of identical molecular size was shown to bind 45Ca in overlays. By immunofluorescence and immunogold labeling this CS-like protein was localized selectively to the extended subplasmalemmal calcium stores, the "alveolar sacs", which cover almost the entire cell surface. Concomitantly the 53 kDa 45Ca-binding band became increasingly intense in overlays as we increasingly enriched alveolar sacs. Antibodies against rat CR react with a 61 kDa band but do not cross-react with CS-like protein in Paramecium. These antibodies selectively stained intracellular reticular structures, identified bona fide as endoplasmic reticulum.

  8. The Estimate of the Optimum Number of Retail Stores of Small Market Areas Using Agent Model

    Science.gov (United States)

    Tajima, Takuya; Hibino, Takayuki; Abe, Takehiko; Kimura, Haruhiko

    At present, the conditions of the location and the optimal arrangements for retail stores of small market areas are examined with the several surveys. The surveys are important because the proceeds are influenced largely with the selection of the location. However, costs, time and experience are necessary in the surveys. For this reason, this research is intended for the retail stores of small market areas which expend a great deal of money for the surveys. The retail stores of small market areas in this paper are convenience stores. The purpose of this paper is to estimate the optimum number of convenience stores by computer simulation. We adopted the agent model. We constructed an agent model that had the customer agent, the shop agent and the landscape with the kind of necessary minimum parameters. And, we were able to make the simulation environment that reflected the real world. As a result, we could estimate the optimum number of convenience stores by simulations.

  9. An exploration study on detecting important factors influencing brand loyalty in retail stores

    Directory of Open Access Journals (Sweden)

    Naser Azad

    2014-01-01

    Full Text Available Brand loyalty is one of the most important factors influencing on the success of retail stores. Many retail stores in the field of sport shoes in city of Tehran, Iran are facing tight competition and there seems to be that only stores with loyal customers could survive. In this paper, we present an exploration study to find out important factors influencing retail stores selling one of well-known sport shows such as Adidas, Nike, etc. in city of Tehran, Iran. The proposed study designs a questionnaire in Likert scale and distributes among 265 regular customers of these stores and analyze them using factor analysis. The results indicate that there were four important factors influencing customer loyalty including brand identification, brand promotion, brand loyalty and characterization of stores.

  10. Stored energy analysis of Zn-5Al eutectic alloy in superplastic deformation

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The stored energy and the energy release during SPD (superplastic deformation) ofa Zn-5Al alloy were studied. The alloy after rolling process gains more stored energy, and the as-rolled specimen can obtain maximum elongation and minimum flow stress without hot holding treatment before SPD. Experimental results show that stored energy release process is along with SPD process and is also an impetus to SPD. The as-rolled Zn-5Al alloy has 48 J/mol stored energy which was measured with DSC (differential scanning calorimeter) and conforms well to the calculated value. The as-rolled Zn-5Al alloy after SPD with an elongation of 2 500% releases 112 J/mol stored energy. Analysis shows that the strain rate is in direct ratio to the rate of stored energy release.

  11. Storing files in a parallel computing system based on user or application specification

    Science.gov (United States)

    Faibish, Sorin; Bent, John M.; Nick, Jeffrey M.; Grider, Gary; Torres, Aaron

    2016-03-29

    Techniques are provided for storing files in a parallel computing system based on a user-specification. A plurality of files generated by a distributed application in a parallel computing system are stored by obtaining a specification from the distributed application indicating how the plurality of files should be stored; and storing one or more of the plurality of files in one or more storage nodes of a multi-tier storage system based on the specification. The plurality of files comprise a plurality of complete files and/or a plurality of sub-files. The specification can optionally be processed by a daemon executing on one or more nodes in a multi-tier storage system. The specification indicates how the plurality of files should be stored, for example, identifying one or more storage nodes where the plurality of files should be stored.

  12. A new approach to a high efficiency inductive store

    Energy Technology Data Exchange (ETDEWEB)

    Zowarka, R.C. Jr.; Kajs, J.P.; Price, J.H.; Weldon, W.F. (Texas Univ., Austin, TX (United States). Center for Electromechanics); Pappas, J.A.; Welden, J.N. (Parker Kinetic Design, Inc., Austin, TX (US))

    1991-01-01

    In the Spring of 1989, Parker Kinetic Design, Inc. (PKD) and the Center for Electromechanics at The University of Texas at Austin (CEM-UT) conducted a study to examine the basic technologies to be used in the construction and operation of a feasible and reliable electromagnetic (EM) gun system. This work was performed for Brown and Root Vickers, Ltd. (BRV) in response to a feasibility analysis requirement of the Royal Armament and Development Establishment (RARDE), Ministry of Defence (MD) of the United Kingdom. This paper summarizes that this study focused on the analysis and evaluation of the suitability and applicability of various pulsed power supply options for the performance goals of the RARDE EM gun program. The existing technologies considered included batteries, compulsators, capacitors, and homopolar generators (HPGs). Primary performance specifications for the electrical energy radius system were that it be capable of providing 12 MJ of muzzle energy; velocities between 2.0 and 3.5 km/s; and a repetitive shot rate of up to 10 shots per day, with no more than a 30-min interval between shots. In addition, the recommended system needed to be reliable, easily maintainable, and capable of routinely firing large numbers of shots. Strict adherence to the goal of designing a system based only on demonstrated technology results in power supplies that are prohibitively expensive and large. As a consequence, candidate system designs represent a modest extrapolation from demonstrated technology well within an acceptable design envelope. A new topology has been developed for a highly efficient inductive store suitable for pulsed-power applications. The new design features high L/R ratios without having to cryogenically cool the conductors. This allows for high efficiency charging of the inductor from low impedance dc sources such as batteries of HPGs.

  13. A DU bed system for storing and supplying hydrogen isotopes

    Energy Technology Data Exchange (ETDEWEB)

    Koo, Daeseo; Park, Jongchul; Ahn, Do-Hee; Chung, Hongsuk [KAERI, Daejeon (Korea, Republic of); Yun, Sei-Hun [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    Depleted uranium (DU) has been extensively proposed for the storage, supply, and recovery of hydrogen isotopes. SDS is used for storing hydrogen isotopes as a metal hydride form. To control the SDS, it is necessary to monitor the tritium amount in a bed. In this study, a full-sized DU bed was designed and fabricated including cylindrical-type copper foam of nine layers to study the characteristics of hydriding/dehydriding and simulate the tritium amount in a bed. The integrity and leak inspection on the welding of a primary vessel was performed using a penetration test, helium leak test, and pressure test. Auto tuning on the cable heaters of two pairs in the DU bed was also be performed. In our next study, the hydriding/dehydriding on a DU bed will be performed. A simulation on the depleted uranium hydriding will be carried out. A DU bed was designed and fabricated including cylindrical-type copper foam of nine layers to study the characteristics of hydriding/dehydriding and simulate the tritium amount in a bed. Through a penetration test, it was confirmed that the welding of the primary vessel has a good integrity. It was confirmed that the two helium tubes is sound by inspecting a helium leak test on the welding of the primary vessel. It was also confirmed that the primary vessel has a good integrity by inspecting a helium leak and conducting a pressure test on it. Vacuuming of the DU bed system was carried out. Vacuuming of the in-bed calorimetric equipment was also carried out.

  14. STAGGERING AND SYNCHRONIZATION OF PRICES IN A LOW INFLATION ENVIRONMENT: EVIDENCE FROM GERMAN FOOD STORES

    OpenAIRE

    Loy, Jens-Peter; Weiss, Christoph R.

    2002-01-01

    Only a few studies have analysed staggering and synchronisation in pricing behaviour of multi-product firms. These studies used low-frequency data in an environment of high rates of inflation. This paper investigates staggering and synchronisation of weekly prices for ten food products in 131 grocery stores in Germany over the period from May 1995 to December 2000 (296 weeks). Different forms of staggering and synchronisation (across-store synchronisation, within type-of-store synchronisation...

  15. The Design and Implementation of Minimal RDFS Backward Reasoning in 4store

    OpenAIRE

    Salvadores, Manuel; Correndo, Gianluca; Harris, Steve; Gibbins, Nicholas; Shadbolt, Nigel

    2011-01-01

    This paper describes the design and implementation of Minimal RDFS semantics based on a backward chaining approach and implemented on a clustered RDF triple store. The system presented, called 4sr, uses 4store as base infrastructure. In order to achieve a highly scalable system we implemented the reasoning at the lowest level of the quad store, the bind operation. The bind operation runs concurrently in all the data slices allowing the reasoning to be processed in parallel among the cluster. ...

  16. Energy saving by optimized controls for supermarket stores; Energie sparen mit optimierter Regeltechnik im Supermarkt

    Energy Technology Data Exchange (ETDEWEB)

    Wendelborn, Horst [Danfoss GmbH, Offenbach (Germany)

    2011-06-15

    Danfoss has been delivering for 20 years the optimizing ADAP-KOOL(R) control system. It enables the store to save 30% of the yearly energy bill, compared to a store with electronic standard controls. Over years the stores took the cheap standard solution, but now several German supermarket chains decide to take the best for the investment and lifecycle cost. This article describes the main control circuits and shows the measurements of the energy consumption of two stores with standard and optimized controls. This control system is available for chemical and for the natural refrigerant R744. (orig.)

  17. Decoupler pylon - A simple, effective wing/store flutter suppressor. [in fighter/attack aircraft

    Science.gov (United States)

    Reed, W. H.; Foughner, J. T., Jr.; Runyan, H. L., Jr.

    1979-01-01

    As an alternative to alleviating wing/store flutter by conventional passive methods or by more advanced active control methods, a quasi-passive concept, referred to as the decoupler pylon, is investigated which combines desirable features of both methods. Passive soft-spring/damper elements are used to decouple wing modes from store pitch modes, and a low-power control system maintains store alignment under changing mean loads. It is shown by analysis and wind tunnel tests that the decoupler pylon provides substantial increase in flutter speed and makes flutter virtually insensitive to inertia and center-of-gravity location of the store.

  18. Food marketing targeting youth and families: what do we know about stores where moms actually shop?

    Science.gov (United States)

    Grigsby-Toussaint, Diana S; Rooney, Mary R

    2013-01-01

    Although efforts are underway to examine marketing that targets the youth and families in the retail food store environment, few studies have specifically focused on stores that families identify as their primary sites for food shopping. Between November 2011 and April 2012, we examined the frequency and types of marketing techniques of 114 packaged and nonpackaged items in 24 food stores that mothers of young children in Champaign County, IL, said they commonly frequented. Chi-square tests were used to determine whether significant differences existed between items with regard to marketing by store type, store food-assistance-program acceptance (i.e., WIC), and claims. Overall, stores accepting WIC and convenience stores had higher frequencies of marketing compared to non-WIC and grocery stores. Fruits and vegetables had the lowest frequency of any marketing claim, while salty snacks and soda had the highest frequency of marketing claims. Nutrition claims were the most common across all items, followed by taste, suggested use, fun, and convenience. Television tie-ins and cartoons were observed more often than movie tie-ins and giveaways. Our results suggest an opportunity to promote healthful items more efficiently by focusing efforts on stores where mothers actually shop.

  19. Store Image and Private Label Brands in Zimbabwe: Relationship with General Perception, Perceived Risk and Quality

    Directory of Open Access Journals (Sweden)

    Sarah Nyengerai

    2013-06-01

    Full Text Available Private label brand market penetration is estimated at less than 8% in Southern Africa. Retailers need to develop strategies that will drive growth of the industry. A survey was conducted to quantify the effect of two store image dimensions on general private label brand perception as well as the effect of the store image dimensions on perceived risk and quality of private label brands. Data collected was analysed using simple linear regression. Results illustrated that perceived store general image as well as store layout and services had a significant (p < 0.05 and positive effect on general private label brand perception. A higher perception of store image dimensions reduced the perceived risk of purchasing private label brands and the effect was significant (p < 0.05. Store image dimensions did not have a significant effect on perceived quality of private label brands. The authors concluded that there is scope to improve PLB perception among consumers in Zimbabwe through improvements in store image dimensions. They recommended that retailers hone on store image through measures such as selling a wide selection of good quality products; the creation of a good store atmosphere and investment in the training of staff in customers care.

  20. Availability of Medical and Recreational Marijuana Stores and Neighborhood Characteristics in Colorado

    Directory of Open Access Journals (Sweden)

    Yuyan Shi

    2016-01-01

    Full Text Available Objective. To examine the availability of marijuana stores in Colorado and associations with neighborhood characteristics. Methods. The addresses for 650 medical and recreational marijuana stores were geocoded and linked to the characteristics of 1249 census tracts in Colorado. Accounting for spatial autocorrelations, autologistic regressions were used to quantify the associations of census tract socioeconomic characteristics with the availability of marijuana stores. Results. Regardless of store types, marijuana stores were more likely to locate in neighborhoods that had a lower proportion of young people, had a higher proportion of racial and ethnic minority population, had a lower household income, had a higher crime rate, or had a greater density of on-premise alcohol outlets. The availability of medical and recreational marijuana stores was differentially correlated with household income and racial and ethnic composition. Conclusions. Neighborhood disparities existed in the availability of marijuana stores, and associations between availability of stores and neighborhood characteristics varied by store types. This study highlighted the need for regulatory measures to prevent marijuana related outcomes in high risk neighborhoods.

  1. Discharge Flux Variability in Stored Thermal Energy Cookstoves

    Science.gov (United States)

    Bryant, Michael James

    A thermal analysis and test is performed to determine flux and temperature variability for Phase change thermal energy to investigation feasibility of use in a Stored Thermal Energy Cookstove (STEC). The phase change material (PCM) NaNO3-KNO3 Eutectic (52:48) Solar Salt is identified for energy storage in STEC due to a melting temperature of 222°C which is deemed appropriate for use in cooking up to temperatures of 200°C +/- 20°C. 1-D planar and cylindrical analytical multiphase solutions are correlated with a transient non-linear ANSYS Finite Element Model (FEM). 1-D idealized models of planar and cylindrical analytical multiphase solutions show the flux stability of cylindrical solidification is twice that of planar solidification. Flux drops a linear average of 0.5%/min in the last half hour of a one hour cooking session in cylindrical solidification vs 1%/min in planar solidification under a constant temperature (dirichlet) boundary condition of 42°C below the melting point of the PCM. Solidification progresses more quickly in the planar case yielding a solid PCM thickness of 3.3 cm after one hour vs 2.4 cm in the cylindrical case. A test is performed on a simplified simple STEC apparatus to investigate cooling rates of the cooking surface while boiling water. 0.5L of water is brought to boil from room temperature with a linear average cooking surface flux of 21,000 W/m2 and a cooking surface cooling rate of 3.8°C/min. Results show increasing the thermal conductivity of the PCM and reducing the total thickness of the solidifying PCM layer before and after discharge will reduce cooling rates, improve stability of the flux delivery device, and increase feasibility of use. Pursuing lower flux cooking and non-cooking applications may increase likelihood of adoption by reducing thermal gradients during discharge. A proposal to explore further development of STEC to aid adoption is discussed.

  2. Colorectal cancer and 18FDG-PET/CT: What about adding the T to the N parameter in loco-regional staging?

    Institute of Scientific and Technical Information of China (English)

    Pier Paolo Mainenti; Delfina Iodice; Sabrina Segreto; Giovanni Storto; Mario Magliulo; Giovanni Domenico De Palma; Marco Salvatore; Leonardo Pace

    2011-01-01

    AIM: To evaluate whether FDG-positron emission tomography (PET)/computed tomography (CT) may be an accurate technique in the assessment of the T stage in patients with colorectal cancer. METHODS: Thirty four consecutive patients (20 men and 14 women; mean age: 63 years) with a histologically proven diagnosis of colorectal adenocarcinoma and scheduled for surgery in our hospital were enrolled in this study. All patients underwent FDG-PET/CT preoperatively. The primary tumor site and extent were evaluated on PET/CT images. Colorectal wall invasion was analysed according to a modified T classification that considers only three stages (≤ T2, T3, T4). Assessment of accuracy was carried out using 95% confidence intervals for T. RESULTS: Thirty five/37 (94.6%) adenocarcinomas were identified and correctly located on PET/CT images. PET/CT correctly staged the T of 33/35 lesions identified showing an accuracy of 94.3% (95% CI: 87%-100%). All T1, T3 and T4 lesions were correctly staged, while two T2 neoplasms were overstated as T3. CONCLUSION: Our data suggest that FDG-PET/CT may be an accurate modality for identifying primary tumor and defining its local extent in patients with colorectal cancer.

  3. SU-E-J-243: Reproducibility of Radiomics Features Through Different Voxel Discretization Levels in F18-FDG PET Images of Cervical Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Altazi, B; Fernandez, D; Zhang, G; Biagioli, M; Moros, E; Moffitt, H. Lee [Cancer Center, Tampa, FL, University of South Florida, Tampa, FL (United States)

    2015-06-15

    Purpose: Site-specific investigations of the role of Radiomics in cancer diagnosis and therapy are needed. We report of the reproducibility of quantitative image features over different discrete voxel levels in PET/CT images of cervical cancer. Methods: Our dataset consisted of the pretreatment PET/CT scans from a cohort of 76 patients diagnosed with cervical cancer, FIGO stage IB-IVA, age range 31–76 years, treated with external beam radiation therapy to a dose range between 45–50.4 Gy (median dose: 45 Gy), concurrent cisplatin chemotherapy and MRI-based Brachytherapy to a dose of 20–30 Gy (median total dose: 28 Gy). Two board certified radiation oncologists delineated Metabolic Tumor volume (MTV) for each patient. Radiomics features were extracted based on 32, 64, 128 and 256 discretization levels (DL). The 64 level was chosen to be the reference DL. Features were calculated based on Co-occurrence (COM), Gray Level Size Zone (GLSZM) and Run-Length (RLM) matrices. Mean Percentage Differences (Δ) of features for discrete levels were determined. Normality distribution of Δ was tested using Kolomogorov - Smirnov test. Bland-Altman test was used to investigate differences between feature values measured on different DL. The mean, standard deviation and upper/lower value limits for each pair of DL were calculated. Interclass Correlation Coefficient (ICC) analysis was performed to examine the reliability of repeated measures within the context of the test re-test format. Results: 3 global and 5 regional features out of 48 features showed distribution not significantly different from a normal one. The reproducible features passed the normality test. Only 5 reproducible results were reliable, ICC range 0.7 – 0.99. Conclusion: Most of the radiomics features tested showed sensitivity to voxel level discretization between (32 – 256). Only 4 GLSZM, 3 COM and 1 RLM showed insensitivity towards mentioned discrete levels.

  4. SU-E-J-258: Prediction of Cervical Cancer Treatment Response Using Radiomics Features Based On F18-FDG Uptake in PET Images

    Energy Technology Data Exchange (ETDEWEB)

    Altazi, B; Fernandez, D; Zhang, G; Biagioli, M; Moros, E; Moffitt, H. Lee [Cancer Center, Tampa, FL, University of South Florida, Tampa, FL (United States)

    2015-06-15

    Purpose: Radiomics have shown potential for predicting treatment outcomes in several body sites. This study investigated the correlation between PET Radiomics features and treatment response of cervical cancer outcomes. Methods: our dataset consisted of a cohort of 79 patients diagnosed with cervical cancer, FIGO stage IB-IVA, age range 25–86 years, (median age at diagnosis: 50 years) all treated between: 2009–14 with external beam radiation therapy to a dose range between: 45–50.4 Gy (median= 45 Gy), concurrent cisplatin chemotherapy and MRI-based brachytherapy to a dose of 20–30 Gy (median= 28 Gy). Metabolic Tumor Volume (MTV) in patient’s primary site was delineated on pretreatment PET/CT by two board certified Radiation Oncologists. The features extracted from each patient’s volume were: 26 Co-occurrence matrix (COM) Feature, 11 Run-Length Matrix (RLM), 11 Gray Level Size Zone Matrix (GLSZM) and 33 Intensity-based features (IBF). The treatment outcome was divided based on the last follow up status into three classes: No Evidence of Disease (NED), Alive with Disease (AWD) and Dead of Disease (DOD). The ability for the radiomics features to differentiate between the 3 treatments outcome categories were assessed by One-Way ANOVA test with p-value < 0.05 was to be statistically significant. The results from the analysis were compared with the ones obtained previously for standard Uptake Value (SUV). Results: Based on patients last clinical follow-up; 52 showed NED, 17 AWD and 10 DOD. Radiomics Features were able to classify the patients based on their treatment response. A parallel analysis was done for SUV measurements for comparison. Conclusion: Radiomics features were able to differentiate between the three different classes of treatment outcomes. However, most of the features were only able to differentiate between NED and DOD class. Also, The ability or radiomics features to differentiate types of response were more significant than SUV.

  5. Feasibility of perfusion CT technique integrated into conventional {sup 18}FDG/PET-CT studies in lung cancer patients: clinical staging and functional information in a single study

    Energy Technology Data Exchange (ETDEWEB)

    Ippolito, Davide; Capraro, Cristina; Sironi, Sandro [University of Milano-Bicocca, School of Medicine, Milan (Italy); University of Milano-Bicocca, Department of Diagnostic Radiology, H.S. Gerardo Monza, Via Pergolesi 11, Monza, Milan (Italy); Guerra, Luca [University of Milano-Bicocca, School of Medicine, Milan (Italy); San Gerardo Hospital, Department of Nuclear Medicine and PET Unit - Molecular Bioimaging Centre, Monza (Italy); De Ponti, Elena [University of Milano-Bicocca, School of Medicine, Milan (Italy); San Gerardo Hospital, Department of Medical Physics, Monza (Italy); Messa, Cristina [University of Milano-Bicocca, School of Medicine, Milan (Italy); San Gerardo Hospital, Department of Nuclear Medicine and PET Unit - Molecular Bioimaging Centre, Monza (Italy); Tecnomed Foundation, University of Milano-Bicocca, Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)

    2013-02-15

    To assess the additional functional vascular information and the relationship between perfusion measurements and glucose metabolism (SUVmax) obtained by including a perfusion CT study in a whole-body contrast-enhanced PET/CT protocol in primary lung cancer lesions. Enrolled in this prospective study were 34 consecutive patients with a biopsy-proven diagnosis of lung cancer who were referred for contrast-enhanced PET/CT staging. This prospective study was approved by our institutional review board, and informed consent was obtained from all patients. Perfusion CT was performed with the following parameters: 80 kV, 200 mAs, 30 scans during intravenous injection of 50 ml contrast agent, flow rate 5 ml/s. Another bolus of contrast medium (3.5 ml/s, 80 ml, 60-s delay) was administered to ensure a full diagnostic contrast-enhanced CT scan for clinical staging. The perfusion CT data were used to calculate a range of tumour vascularity parameters (blood flow, blood volume and mean transit time), and tumour FDG uptake (SUVmax) was used as a metabolic indicator. Quantitative and functional parameters were compared and in relation to location, histology and tumour size. The nonparametric Kruskal-Wallis rank sum test was used for statistical analysis. A cut-off value of 3 cm was used according to the TNM classification to discriminate between T1 and T2 tumours (i.e. T1b vs. T2a). There were significant perfusion differences (lower blood volumes and higher mean transit time) between tumours with diameter >30 mm and tumours with diameter <30 mm (p < 0.05; blood volume 5.6 vs. 7.1 ml/100 g, mean transit time 8.6 vs. 3.9 s, respectively). Also there was a trend for blood flow to be lower in larger lesions (p < 0.053; blood flow 153.1 vs. 98.3 ml/100 g tissue/min). Significant inverse correlations (linear regression) were found between blood volume and SUVmax in tumours with diameter >30 mm in diameter. Perfusion CT combined with PET/CT is feasible technique that may provide additional functional information about vascularity and tumour aggressiveness as a result of lower perfusion and higher metabolism shown by larger lesions. (orig.)

  6. Multimodality functional imaging of spontaneous canine tumors using 64CU-ATSM and 18FDG PET/CT and dynamic contrast enhanced perfusion CT

    DEFF Research Database (Denmark)

    Hansen, Anders E; Kristensen, Annemarie T; Law, Ian;

    2012-01-01

    To compare the distribution and uptake of the hypoxia tracer (64)Cu-diacetyl-bis(N(4)-methylthiosemicarbazone) ((64)Cu-ATSM) PET/CT, FDG PET/CT and dynamic contrast enhanced perfusion CT (DCE-pCT) in spontaneous canine tumors. In addition (64)Cu-ATSM distribution over time was evaluated....

  7. Impact of 18FDG-PET/CT on biological target volume (BTV) definition for treatment planning for non-small cell lung cancer patients

    Energy Technology Data Exchange (ETDEWEB)

    Devic, Slobodan [Medical Physics Department, McGill University Health Centre, Montreal, Que. (Canada)]. E-mail: devic@medphys.mcgill.ca; Tomic, Nada [Medical Physics Department, McGill University Health Centre, Montreal, Que. (Canada); Faria, Sergio [Radiation Oncology Department, McGill University Health Centre, Montreal, Que. (Canada); Dean, Geoffrey [Nuclear Medicine Department, McGill University Health Centre, Montreal, Que. (Canada); Lisbona, Robert [Nuclear Medicine Department, McGill University Health Centre, Montreal, Que. (Canada); Parker, William [Medical Physics Department, McGill University Health Centre, Montreal, Que. (Canada); Kaufman, Chris [Medical Physics Department, McGill University Health Centre, Montreal, Que. (Canada); Podgorsak, Ervin B. [Medical Physics Department, McGill University Health Centre, Montreal, Que. (Canada)

    2007-02-01

    This work represents our effort to test feasibility of FDG-based PET/CT on target volume delineation in radiotherapy treatment planning of NSCLC patients. Different methods have been developed to enable more precise target outlining using PET: Qualitative Visual Method, CTV=2.5 SUV units, linear SUV threshold function method, and CTV=40% Iso of Maximum Uptake Value. We are proposing reconstruction of three biological target volumes: necrotic BTV (same as PTV created by radiation oncologist using CT data), proliferating BTV (based on PET signal to background ratio 1:3) and hypoxic BTV (based on PET signal to background ratio of 1:19). Two IMRT plans were created and compared to the conventional treatment plan: 'conservative' IMRT plan delivers 52.5 Gy to the necrotic BTV and 65 Gy to the hypoxic BTV; 'radical' IMRT plan delivers 30 Gy to necrotic BTV, 52.5 Gy to proliferating BTV and 65 Gy to hypoxic BTV. Use of BTVs in IMRT plans is attractive because it increases dose to targets considered to need higher doses. It reduces considerably dose to heart and spinal cord, organs considered to limit dose escalation approaches in NSCLC treatment. 'Conservative' IMRT approach can be understood as a PET/CT-based concomitant boost to the tumor expressing the highest FDG uptake. 'Radical' plan implies deviation from the traditional uniform dose target coverage approach, with the intention of achieving better surrounding tissue sparing and ultimately allowing for dose escalation protocols relying on biologically based treatment planning.

  8. Impact of 18FDG-PET/CT on biological target volume (BTV) definition for treatment planning for non-small cell lung cancer patients

    Science.gov (United States)

    Devic, Slobodan; Tomic, Nada; Faria, Sergio; Dean, Geoffrey; Lisbona, Robert; Parker, William; Kaufman, Chris; Podgorsak, Ervin B.

    2007-02-01

    This work represents our effort to test feasibility of FDG-based PET/CT on target volume delineation in radiotherapy treatment planning of NSCLC patients. Different methods have been developed to enable more precise target outlining using PET: Qualitative Visual Method, CTV=2.5 SUV units, linear SUV threshold function method, and CTV=40% Iso of Maximum Uptake Value. We are proposing reconstruction of three biological target volumes: necrotic BTV (same as PTV created by radiation oncologist using CT data), proliferating BTV (based on PET signal to background ratio 1:3) and hypoxic BTV (based on PET signal to background ratio of 1:19). Two IMRT plans were created and compared to the conventional treatment plan: "conservative" IMRT plan delivers 52.5 Gy to the necrotic BTV and 65 Gy to the hypoxic BTV; "radical" IMRT plan delivers 30 Gy to necrotic BTV, 52.5 Gy to proliferating BTV and 65 Gy to hypoxic BTV. Use of BTVs in IMRT plans is attractive because it increases dose to targets considered to need higher doses. It reduces considerably dose to heart and spinal cord, organs considered to limit dose escalation approaches in NSCLC treatment. "Conservative" IMRT approach can be understood as a PET/CT-based concomitant boost to the tumor expressing the highest FDG uptake. "Radical" plan implies deviation from the traditional uniform dose target coverage approach, with the intention of achieving better surrounding tissue sparing and ultimately allowing for dose escalation protocols relying on biologically based treatment planning.

  9. Role of {sup 18}FDG PET/CT in patients treated with {sup 177}Lu-DOTATATE for advanced differentiated neuroendocrine tumours

    Energy Technology Data Exchange (ETDEWEB)

    Severi, Stefano; Sansovini, Maddalena; Ianniello, Annarita; Matteucci, Federica [Cancer Institute of Romagna (IRST), Unit of Radiometabolic Medicine, Meldola, FC (Italy); Nanni, Oriana; Scarpi, Emanuela [Cancer Institute of Romagna (IRST), Unit of Biostatistics and Clinical Trials, Meldola, FC (Italy); Bodei, Lisa; Gilardi, Laura; Paganelli, Giovanni [European Institute of Oncology, Division of Nuclear Medicine, Milan (Italy); Nicoletti, Stefania [Cancer Institute of Romagna (IRST), Unit of Medical Oncology, Meldola, FC (Italy)

    2013-06-15

    The prognostic value of FDG PET for neuroendocrine tumours (NETs) has been reported. In this study we evaluated the role of FDG PET in predicting response and progression-free survival (PFS) after {sup 177}Lu-DOTATATE peptide receptor radionuclide therapy (Lu-PRRT) in patients with advanced well-differentiated grade 1/2 NETs. We retrospectively evaluated 52 patients with progressive advanced NETs overexpressing somatostatin receptors and treated with Lu-PRRT with a cumulative activity up to 27.7 GBq divided into five courses. According to WHO 2010/ENETS classification, patients were stratified into two groups: those with grade 1 tumour (Ki-67 index {<=}2 %, 19 patients), and those with grade 2 tumour (Ki-67 index >3 % to <20 %, 33 patients). On the basis of the FDG PET scan, 33 patients were classified as PET-positive (PET+) and 19 as PET-negative (PET-). FDG PET was positive in 57 % of patients with grade 1 NET and in 66 % of patients with grade 2 NET, and the rates of disease control (DC, i.e. complete response + partial response + stable disease) in grade 1 and grade 2 patients were 95 % and 79 %, respectively (P = 0.232). In PET- and PET+ patients, the DC rates were 100 % and 76 % (P = 0.020) with a PFS of 32 and 20 months, respectively (P = 0.033). Of the PET+ patients with grade 1 NET, 91 % showed disease control, whereas about one in three PET+ patients with grade 2 NET (32 %) progressed after Lu-PRRT (DC rate 68 %). These results suggest that FDG PET evaluation is useful for predicting response to Lu-PRRT in patients with grade 1/2 advanced NETs. Notably, none of PET- patients had progressed at the first follow-up examination after Lu-PRRT. Grade 2 NET and PET+ (arbitrary SUV cutoff >2.5) were frequently associated with more aggressive disease. PET+ patients with grade 2 NET, 32 % of whom did not respond to Lu-PRRT monotherapy, might benefit from more intensive therapy protocols, such as the combination of chemotherapy and PRRT. (orig.)

  10. Preoperative F-18-FDG PET for the detection of metastatic cervical lymph nodes in recurrent papillary thyroid carcinoma patients with negative I-131 whole body scans

    Energy Technology Data Exchange (ETDEWEB)

    Byun, Byung Hyun; Urn, Sang Moo; Cheon, Gi Jeong; Choi, Chang Woon; Lee, Byeong Cheol; Lee, Guk Haeng; Lee, Yong Sik; Shim, Youn Sang [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

    2007-07-01

    We evaluated the diagnostic performance of FDG-PET for the detection of metastatic cervical lymph nodes in recurrent papillary thyroid carcinoma patients with negative I-131 scan. All patients had total thyroidectomy and following I-131 ablation therapy. In the follow-up period, FDG-PET showed suspected cervical lymph nodes metastases and neck dissection was performed within 3 months after FDG-PET. It had shown for all patients the negative I-131 scan within 3 months before FDG-PET or negative I-131 scan during the period of cervical lymph nodes metastases suspected on the basis of FDG-PET, CT, or ultrasonography until the latest FDG-PET. Preoperative FDG-PET results were compared with the pathologic findings of lymph nodes specimens of 19 papillary thyroid carcinoma patients. Serum Tg, TSH, and Tg antibody levels at the time of latest I-131 scan were reviewed. The size of lymph node was measured by preoperative CT or ultrasonography. In 45 cervical lymph node groups dissected, 31 lymph node groups revealed metastasis. The sensitivity and specificity of FDG-PET for metastasis were 74.2% (23 of 31) and 50.0% (7 of 14), respectively. Except for patients with elevated Tg antibody levels, all patients showed the elevated serum Tg levels than normal limits at the TSH of =30uIU/ml. 8 lesions without suspected metastatic findings on FDG-PET revealed metastasis (false negative), and none of them exceeded 8mm in size (4 to 8mm, median= 6mm). On the other hand, 23 true positive lesions on FDG-PET were variable in size (6 to 17mm, median=9mm). FDG-PET is suitable for the detection of metastatic cervical lymph nodes in patients with recurrent papillary thyroid carcinoma. However, false positive or false negative should be considered according to the size of lymph node.

  11. Predictive Role of Functional Visceral Fat Activity Assessed by Preoperative F-18 FDG PET/CT for Regional Lymph Node or Distant Metastasis in Patients with Colorectal Cancer.

    Directory of Open Access Journals (Sweden)

    Kisoo Pahk

    Full Text Available To investigate the role of functional visceral fat activity assessed by preoperative F-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT in colorectal cancer (CRC for predicting regional lymph node (LN or distant metastasis.We evaluated 131 patients with newly diagnosed CRC. They all underwent pre-operative 18F-FDG PET/CT and surgery. Functional fat activity was measured by maximum standardized uptake value (SUVmax using 18F-FDG PET/CT. Functional visceral fat activity was measured by SUVmax of visceral fat/SUVmax of subcutaneous fat (V/S ratio. Mann-Whitney U test, χ2 test, Fisher's exact test, receiver-operating characteristic (ROC analysis, Spearrman's correlation coefficient, and uni- and multivariate logistic regression statistical analyses were done.Patients with higher V/S ratio displayed a significantly higher rate of regional LN (p = 0.004 and distant metastasis (p<0.001. In addition, V/S ratio was the only factor that was significantly associated with distant metastasis. An optimal cut-off V/S ratio of 1.88 was proposed for predicting distant metastasis with a sensitivity of 84.6% and specificity of 78.8% (area under the curve: 0.86; p<0.0001.Functional visceral fat activity is significantly associated with distant metastasis in CRC patients. Furthermore, V/S ratio can be useful as a complementary factor in predicting distant metastasis.

  12. Residual F-18-FDG-PET Uptake 12 Weeks After Stereotactic Ablative Radiotherapy for Stage I Non-Small-Cell Lung Cancer Predicts Local Control

    NARCIS (Netherlands)

    Bollineni, Vikram Rao; Widder, Joachim; Pruim, Jan; Langendijk, Johannes A.; Wiegman, Erwin M.

    2012-01-01

    Purpose: To investigate the prognostic value of [F-18]fluorodeoxyglucose positron emission tomography (FDG-PET) uptake at 12 weeks after stereotactic ablative radiotherapy (SABR) for stage I non-small-cell lung cancer (NSCLC). Methods and Materials: From November 2006 to February 2010, 132 medically

  13. In Vivo 18-FDG/18-Choline-Mediated Cerenkov Radiation Energy Transfer (CRET) Multiplexed Optical Imaging for Human Prostate Carcinoma Detection and Staging

    Science.gov (United States)

    2014-10-01

    cancer detection and new prostate cancer therapies are needed. Two novel biomarkers are proposed to associate with prostate cancer progression: the...15. SUBJECT TERMS prostate cancer, ErbB2, ErbB3, molecular imaging, PET, phage display, TF antigen 16. SECURITY CLASSIFICATION OF: 17...Therefore, more sensitive means of early prostate cancer detection and new prostate cancer therapies are needed. Unquestionably, better biomarkers of

  14. Rapid reduction of sigma(1)-Receptor binding and F-18-FDG uptake in rat gliomas after in vivo treatment with doxorubicin

    NARCIS (Netherlands)

    van Waarde, Aren; Shiba, Kazuhiro; de Jong, Johan R.; Ishiwata, Kiichi; Dierckx, Rudi A.; Elsinga, Philip H.

    2007-01-01

    sigma-Receptors are strongly overexpressed in most rodent and human tumors and are proliferation markers. To evaluate the potential of a radiolabeled sigma(1)-ligand for therapy monitoring, we compared early changes of C-11-1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine (C-11-SA4503) bindin

  15. Abnormal brain glucose metabolism and depressive mood in patients with pre-dialytic chronic kidney disease: SPM analysis of F-18 FDG positron emission tomography

    Energy Technology Data Exchange (ETDEWEB)

    Jun, Sung Min; Song, Sang Heon; Kim, Seong Jang; Kim, Ji Hoon; Kwak, Ihm Soo; Kim, In Ju; Kim, Yong Ki [Pusan National University Hospital, Pusan (Korea, Republic of)

    2007-07-01

    The aim of this study was to investigate the relationship between depressive mood and pre-dialytic CKD, to localize and quantify depressive mood -related lesions in pre-dialytic CKD patients through statistical parametric mapping (SPM) analysis of brain positron emission tomography (PET), and to examine the usefulness of brain PET for early detection and proper treatment of depressive mood. Twenty one patients with stage 5 CKD and 22 healthy volunteers were analyzed by depressive mood assessment and statistical parametric mapping (SPM) analysis of 18F-FDG PET. Depressive mood assessment was done by Beck Depression Inventory (BDI) and Hamilton Depression Rating Scale (HDRS). The largest clusters were areas including precentral gyrus, prefrontal cortex, and anterior cingulated cortex of left hemisphere. Other clusters were left transverse temporal gyrus, left superior temporal gyrus, right prefrontal cortex, right dorsolateral prefrontal cortex (BA 46, 44), right inferior frontal gyrus, right inferior parietal lobule, left angular gyrus. In addition, correlation was found between hypometabolized areas and HDRS scores of CKD patients in right prefrontal cortex (BA 11) and right anterior cingulated gyrus (BA 24). In conclusion, this study demonstrated specific depressive mood-related abnormal metabolic lesion. Interestingly, in CKD patients with severe depressive mood, cerebral metabolism was similar to that of MDD.

  16. The Compression Flow as a Measure to Estimate the Cognitive Impairment Severity in Resting State fMRI and 18FDG-PET Alzheimer's Disease Connectomes

    Directory of Open Access Journals (Sweden)

    Antonio Giuliano Zippo

    2015-12-01

    Full Text Available The human brain appears organized in compartments characterized by seemingly specific functional purposes on many spatial scales. A complementary functional state binds information from specialized districts to return what is called integrated information. This fundamental network dynamics undergoes to severe disarrays in diverse degenerative conditions such as Alzheimer's Diseases (AD. The AD represents a multifarious syndrome characterized by structural, functional and metabolic landmarks. In particular, in the early stages of AD, adaptive functional modifications of the brain networks mislead initial diagnoses because cognitive abilities may result indiscernible from normal subjects. As a matter of facts, current measures of functional integration fail to catch significant differences among normal, mild cognitive impairment (MCI and even AD subjects. The aim of this work is to introduce a new topological feature called Compression Flow (CF to finely estimate the extent of the functional integration in the brain networks. The method uses a Monte Carlo-like estimation of the information integration flows returning the compression ratio between the size of the injected information and the size of the condensed information within the network. We analyzed the resting state connectomes of 75 subjects of the Alzheimer's Disease Neuroimaging Initiative 2 (ADNI repository. Our analyses are focused on the 18FGD-PET and functional MRI (fMRI acquisitions in several clinical screening conditions. Results indicated that CF effectively discriminate MCI, AD and normal subjects by showing a significant decrease of the functional integration in the AD and MCI brain connectomes. This result did not emerge by using a set of common complex network statistics. Furthermore, CF was best correlated with individual clinical scoring scales. In conclusion, we presented a novel measure to quantify the functional integration that resulted efficient to discriminate different stages of dementia and to track the individual progression of the impairments prospecting a proficient usage in a wide range of pathophysiological and physiological studies as well.

  17. F-18-FDG-PET Confined Radiotherapy of Locally Advanced NSCLC With Concomitant Chemotherapy: Results of the PET-PLAN Pilot Trial

    Energy Technology Data Exchange (ETDEWEB)

    Fleckenstein, Jochen [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany); Hellwig, Dirk [Department of Nuclear Medicine, Saarland University Medical School, Homburg (Germany); Kremp, Stephanie [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany); Grgic, Aleksandar [Department of Nuclear Medicine, Saarland University Medical School, Homburg (Germany); Groeschel, Andreas [Department of Internal Medicine V, Saarland University Medical School, Homburg (Germany); Kirsch, Carl-Martin [Department of Nuclear Medicine, Saarland University Medical School, Homburg (Germany); Nestle, Ursula [Department of Nuclear Medicine, Saarland University Medical School, Homburg (Germany); Clinic for Radiotherapy, University Hospital, Freiburg (Germany); Ruebe, Christian, E-mail: christian.ruebe@uks.eu [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany)

    2011-11-15

    Purpose: The integration of fluoro-deoxy-D-glucose positron emission tomography (FDG-PET) in the process of radiotherapy (RT) planning of locally advanced non-small-cell lung cancer (NSCLC) may improve diagnostic accuracy and minimize interobserver variability compared with target volume definition solely based on computed tomography. Furthermore, irradiating only FDG-PET-positive findings and omitting elective nodal regions may allow dose escalation by treating smaller volumes. The aim of this prospective pilot trial was to evaluate the therapeutic safety of FDG-PET-based RT treatment planning with an autocontour-derived delineation of the primary tumor. Methods and Materials: Eligible patients had Stages II-III inoperable NSCLC, and simultaneous, platinum-based radiochemotherapy was indicated. FDG-PET and computed tomography acquisitions in RT treatment planning position were coregistered. The clinical target volume (CTV) included the FDG-PET-defined primary tumor, which was autodelineated with a source-to-background algorithm, plus FDG-PET-positive lymph node stations. Limited by dose restrictions for normal tissues, prescribed total doses were in the range of 66.6 to 73.8 Gy. The primary endpoint was the rate of out-of-field isolated nodal recurrences (INR). Results: As per intent to treat, 32 patients received radiochemotherapy. In 15 of these patients, dose escalation above 66.6 Gy was achieved. No Grade 4 toxicities occurred. After a median follow-up time of 27.2 months, the estimated median survival time was 19.3 months. During the observation period, one INR was observed in 23 evaluable patients. Conclusions: FDG-PET-confined target volume definition in radiochemotherapy of NSCLC, based on a contrast-oriented source-to-background algorithm, was associated with a low risk of INR. It might provide improved tumor control because of dose escalation.

  18. Radiography, Bone Scan, and F-18 FDG PET/CT Imaging Findings in a Patient with Paget's Disease

    Energy Technology Data Exchange (ETDEWEB)

    Park, Eun Tae; Kim, Sung Eun [Korea University Guro Hospital, Seoul (Korea, Republic of)

    2010-04-15

    Background A 52-year-old female patient sought evaluation at our hospital for an incidental abnormal finding on an abdominal radiograph. The initial radiograph showed irregular sclerotic changes involving the right pelvic bone. At the same time, bone scintigraphy showed intense hot uptake in the right iliac and pubic bones. CT images showed characteristic thickening of the pelvic brim, suggesting the mixed phase of Paget's disease. The level of alkaline phosphatase (ALP) was 266 IU/I. {sup 18}F-FDG PET/CT images also showed diffusely increased {sup 18}F-FDG uptake in the right pelvic bone. However, the findings of {sup 18}F-FDG PET/CT were less notable than those of bone scintigraphy. We report the imaging findings of a patient with Paget's disease evaluated by radiography, bone scintigraphy, and {sup 18}F-FDG PET/CT.

  19. A Prospective Study of {sup 18}FDG-PET With CT Coregistration for Radiation Treatment Planning of Lymphomas and Other Hematologic Malignancies

    Energy Technology Data Exchange (ETDEWEB)

    Terezakis, Stephanie A. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland (United States); Schöder, Heiko [Department of Nuclear Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Kowalski, Alexander; McCann, Patrick [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Lim, Remy; Turlakov, Alla [Department of Nuclear Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Gonen, Mithat [Department of Statistics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Barker, Chris; Goenka, Anuj; Lovie, Shona [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Yahalom, Joachim, E-mail: yahalomj@mskcc.org [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)

    2014-06-01

    Purpose: This prospective single-institution study examined the impact of positron emission tomography (PET) with the use of 2-[{sup 18}F] fluoro-2-deoxyglucose and computed tomography (CT) scan radiation treatment planning (TP) on target volume definition in lymphoma. Methods and Materials: 118 patients underwent PET/CT TP during June 2007 to May 2009. Gross tumor volume (GTV) was contoured on CT-only and PET/CT studies by radiation oncologists (ROs) and nuclear medicine physicians (NMPs) for 95 patients with positive PET scans. Treatment plans and dose-volume histograms were generated for CT-only and PET/CT for 95 evaluable sites. Paired t test statistics and Pearson correlation coefficients were used for analysis. Results: 70 (74%) patients had non-Hodgkin lymphoma, 10 (11%) had Hodgkin lymphoma, 12 (10%) had plasma-cell neoplasm, and 3 (3%) had other hematologic malignancies. Forty-three (45%) presented with relapsed/refractory disease. Forty-five (47%) received no prior chemotherapy. The addition of PET increased GTV as defined by ROs in 38 patients (median, 27%; range, 5%-70%) and decreased GTV in 41 (median, 39.5%; range, 5%-80%). The addition of PET increased GTV as defined by NMPs in 27 patients (median, 26.5%; range, 5%-95%) and decreased GTV in 52 (median, 70%; range, 5%-99%). The intraobserver correlation between CT-GTV and PET-GTV was higher for ROs than for NMPs (0.94, P<.01 vs 0.89, P<.01). On the basis of Bland-Altman plots, the PET-GTVs defined by ROs were larger than those defined by NMPs. On evaluation of clinical TPs, only 4 (4%) patients had inadequate target coverage (D95 <95%) of the PET-GTV defined by NMPs. Conclusions: Significant differences between the RO and NMP volumes were identified when PET was coregistered to CT for radiation planning. Despite this, the PET-GTV defined by ROs and NMPs received acceptable prescription dose in nearly all patients. However, given the potential for a marginal miss, consultation with an experienced PET reader is highly encouraged when PET/CT volumes are delineated, particularly for questionable lesions and to assure complete and accurate target volume coverage.

  20. Three-dimensional texture analysis of contrast enhanced CT images for treatment response assessment in Hodgkin lymphoma: Comparison with F-18-FDG PET

    Energy Technology Data Exchange (ETDEWEB)

    Knogler, Thomas; El-Rabadi, Karem; Weber, Michael; Karanikas, Georgios; Mayerhoefer, Marius E., E-mail: marius.mayerhoefer@meduniwien.ac.at [Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090 (Austria)

    2014-12-15

    Purpose: To determine the diagnostic performance of three-dimensional (3D) texture analysis (TA) of contrast-enhanced computed tomography (CE-CT) images for treatment response assessment in patients with Hodgkin lymphoma (HL), compared with F-18-fludeoxyglucose (FDG) positron emission tomography/CT. Methods: 3D TA of 48 lymph nodes in 29 patients was performed on venous-phase CE-CT images before and after chemotherapy. All lymph nodes showed pathologically elevated FDG uptake at baseline. A stepwise logistic regression with forward selection was performed to identify classic CT parameters and texture features (TF) that enable the separation of complete response (CR) and persistent disease. Results: The TF fraction of image in runs, calculated for the 45° direction, was able to correctly identify CR with an accuracy of 75%, a sensitivity of 79.3%, and a specificity of 68.4%. Classical CT features achieved an accuracy of 75%, a sensitivity of 86.2%, and a specificity of 57.9%, whereas the combination of TF and CT imaging achieved an accuracy of 83.3%, a sensitivity of 86.2%, and a specificity of 78.9%. Conclusions: 3D TA of CE-CT images is potentially useful to identify nodal residual disease in HL, with a performance comparable to that of classical CT parameters. Best results are achieved when TA and classical CT features are combined.