WorldWideScience

Sample records for 1st nci epi

  1. NCI Designated Cancer Centers

    Science.gov (United States)

    ... Resources Conducting Clinical Trials Statistical Tools and Data Terminology Resources NCI Data Catalog Cryo-EM NCI's Role ... Report (RPPR) Grant Closeout Grant Resources NCI Grants Management Legal Requirements NCI Grant Policies Grants Management Contacts ...

  2. Emerging Pathogens Initiative (EPI)

    Data.gov (United States)

    Department of Veterans Affairs — The Emerging Pathogens Initiative (EPI) database contains emerging pathogens information from the local Veterans Affairs Medical Centers (VAMCs). The EPI software...

  3. Emergency Preparedness at NCI

    Science.gov (United States)

    Information to help prepare for an emergency. Includes resources for patients and health care providers to continue cancer care, NCI contacts for grantees, and resources to prepare and update NCI employees and contractors.

  4. NCI & Division Obligations

    Science.gov (United States)

    Displays obligations for grants, contracts, training fellowships, intramural research, and management and support, including the number of grant awards, funding amounts, and percent of the total NCI budget.

  5. NCI Contact Center

    Science.gov (United States)

    The NCI offers free, scientifically accurate, and easy-to-understand information on a range of cancer topics in English and Spanish. Get live help from compassionate information specialists at 1-800-4-CANCER.

  6. NCI at ASCO

    Science.gov (United States)

    NCI-designated cancer centers are being extensively represented at the annual meeting of the American Society for Clinical Oncology meeting in Chicago this year with a large array of clinical trial results and findings.

  7. NCI Visuals Online

    Science.gov (United States)

    NCI Visuals Online contains images from the collections of the National Cancer Institute's Office of Communications and Public Liaison, including general biomedical and science-related images, cancer-specific scientific and patient care-related images, and portraits of directors and staff of the National Cancer Institute.

  8. Data Sets from Major NCI Initiaves

    Science.gov (United States)

    The NCI Data Catalog includes links to data collections produced by major NCI initiatives and other widely used data sets, including animal models, human tumor cell lines, epidemiology data sets, genomics data sets from TCGA, TARGET, COSMIC, GSK, NCI60.

  9. NCI-Molecular Analysis for Therapy Choice (NCI-MATCH) Trial

    Science.gov (United States)

    NCI's gateway for information about the NCI-Molecular Analysis for Therapy Choice (NCI-MATCH) trial, in which patients with advanced cancer are assigned to treatment arms based on the molecular profiles of their disease.

  10. NCI Alliance for Nanotechnology in Cancer

    Science.gov (United States)

    The NCI Alliance for Nanotechnology in Cancer funds the Cancer Nanotechnology Training Centers collectively with the NCI Cancer Training Center. Find out about the funded Centers, to date, that train our next generation of scientists in the field of Canc

  11. NCI collaborates with Multiple Myeloma Research Foundation

    Science.gov (United States)

    The National Cancer Institute (NCI) announced a collaboration with the Multiple Myeloma Research Foundation (MMRF) to incorporate MMRF's wealth of genomic and clinical data on the disease into the NCI Genomic Data Commons (GDC), a publicly available datab

  12. CDC WONDER: Population - Bridged-Race July 1st Estimates

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Population - Bridged-Race July 1st Estimates online databases report bridged-race population estimates of the July 1st resident population of the United States,...

  13. 1st Applied Electromagnetic International Conference

    CERN Document Server

    Othman, Mohd; Aziz, Mohamad; Malek, Mohd

    2015-01-01

    In this book, experts from academia and industry present the latest advances in scientific theory relating to applied electromagnetics and examine current and emerging applications particularly within the fields of electronics, communications, and computer technology. The book is based on presentations delivered at APPEIC 2014, the 1st Applied Electromagnetic International Conference, held in Bandung, Indonesia in December 2014. The conference provided an ideal platform for researchers and specialists to deliver both theoretically and practically oriented contributions on a wide range of topics relevant to the theme of nurturing applied electromagnetics for human technology. Many novel aspects were addressed, and the contributions selected for this book highlight the relevance of advances in applied electromagnetics to a variety of industrial engineering problems and identify exciting future directions for research.

  14. Mylan to Offer Generic EpiPen

    Science.gov (United States)

    ... news/fullstory_160669.html Mylan to Offer Generic EpiPen Manufacturer responds to mounting criticism about price hikes ... cheaper generic version of the emergency allergy treatment EpiPen will be made available within the next few ...

  15. Join TTC! | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The NCI Technology Transfer Center (TTC) offers a unique opportunity for training through the NCI TTC Fellowship program. TTC also has a unit dedicated to marketing these research opportunities and their underlying technologies to potential collaborators and licensees. | [google6f4cd5334ac394ab.html

  16. Trans-NCI Pharmacogenomics and Pharmacoepidemiology Working Group (PPWG)

    Science.gov (United States)

    NCI established the Trans-NCI Pharmacogenomics and Pharmacoepidemiology Working Group to support development of a comprehensive and interdisciplinary pharmacoepidemiology and pharmacogenomics cancer research program.

  17. Identification and characterization of two novel cytosolic sulfotransferases, SULT1 ST7 and SULT1 ST8, from zebrafish

    Energy Technology Data Exchange (ETDEWEB)

    Liu, T.-A. [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States); Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan (China); Bhuiyan, Shakhawat [Division of Arts and Sciences, Jarvis Christian College, Hawkins, TX 75765 (United States); Snow, Rhodora [School of Mathematics and Science, J. Sargeant Reynolds Community College, Richmond, VA 23285 (United States); Yasuda, Shin; Yasuda, Tomoko [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States); Yang, Y.-S. [Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan (China); Williams, Frederick E.; Liu, M.-Y.; Suiko, Masahito [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States); Carter, Glendora [School of Mathematics and Science, J. Sargeant Reynolds Community College, Richmond, VA 23285 (United States); Liu, M.-C. [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States)], E-mail: ming.liu@utoledo.edu

    2008-08-29

    Cytosolic sulfotransferases (SULTs) constitute a family of Phase II detoxification enzymes that are involved in the protection against potentially harmful xenobiotics as well as the regulation and homeostasis of endogenous compounds. Compared with humans and rodents, the zebrafish serves as an excellent model for studying the role of SULTs in the detoxification of environmental pollutants including environmental estrogens. By searching the expressed sequence tag database, two zebrafish cDNAs encoding putative SULTs were identified. Sequence analysis indicated that these two putative zebrafish SULTs belong to the SULT1 gene family. The recombinant form of these two novel zebrafish SULTs, designated SULT1 ST7 and SULT1 ST8, were expressed using the pGEX-2TK glutathione S-transferase (GST) gene fusion system and purified from transformed BL21 (DE3) cells. Purified GST-fusion protein form of SULT1 ST7 and SULT1 ST8 exhibited strong sulfating activities toward environmental estrogens, particularly hydroxylated polychlorinated biphenyls (PCBs), among various endogenous and xenobiotic compounds tested as substrates. pH-dependence experiments showed that SULT1 ST7 and SULT1 ST8 displayed pH optima at 6.5 and 8.0, respectively. Kinetic parameters of the two enzymes in catalyzing the sulfation of catechin and chlorogenic acid as well as 3-chloro-4-biphenylol were determined. Developmental expression experiments revealed distinct patterns of expression of SULT1 ST7 and SULT1 ST8 during embryonic development and throughout the larval stage onto maturity.

  18. EMSL Quarterly Highlights Report: 1st Quarter, Fiscal Year 2009

    Energy Technology Data Exchange (ETDEWEB)

    Showalter, Mary Ann; Kathmann, Loel E.; Manke, Kristin L.

    2009-02-02

    The EMSL Quarterly Highlights Report covers the science, staff and user recognition, and publication activities that occurred during the 1st quarter (October 2008 - December 2008) of Fiscal Year 2009.

  19. Electronic Health Records Place 1st at Indy 500

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues EHR Electronic Health Records Place 1st at Indy 500 Past ... last May's Indy 500 had thousands of personal Electronic Health Records on hand for those attending—and ...

  20. EMSL Quarterly Highlights Report: 1st Quarter, FY08

    Energy Technology Data Exchange (ETDEWEB)

    Showalter, Mary Ann

    2008-01-28

    The EMSL Quarterly Highlights Report covers the science, staff and user recognition, and publication activities that occurred during the 1st quarter (October 2007 - December 2007) of Fiscal Year 2008.

  1. Texas Reports 1st Likely Case of Local Zika Infection

    Science.gov (United States)

    ... html Texas Reports 1st Likely Case of Local Zika Infection Woman had no travel-related risk factors, ... reported its first possible case of locally transmitted Zika infection on Monday. If confirmed, Texas would join ...

  2. FDA OKs 1st Drug to Treat Duchenne Muscular Dystrophy

    Science.gov (United States)

    ... html FDA OKs 1st Drug to Treat Duchenne Muscular Dystrophy Exondys 51 seems to fill unmet need ... the first drug for a rare form of muscular dystrophy. Exondys 51 (eteplirsen) was granted accelerated approval ...

  3. NCI Central Review Board Receives Accreditation

    Science.gov (United States)

    The Association for the Accreditation of Human Research Protection Programs has awarded the NCI Central Institutional Review Board full accreditation. AAHRPP awards accreditation to organizations demonstrating the highest ethical standards in clinical res

  4. Dinutuximab (Unituxin™) | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    In 2010, NCI entered into a Cooperative Research and Development Agreement (CRADA) with United Therapeutics Corp., under which the company assumed responsibility for manufacturing dinutuximab and moving it through the steps required for regulatory approval.

  5. International Fellows of NCI at Frederick | Poster

    Science.gov (United States)

    Each year, the Employee Diversity Team (EDT) acknowledges members of the NCI at Frederick Community for their achievements and contributions towards the mission of facility.  Historically, the team has profiled the “Women of NCI at Frederick,” but this year, the team decided to instead shed light on the diverse and successful individuals who make up the international fellows community.

  6. International Fellows of NCI at Frederick | Poster

    Science.gov (United States)

    Each year, the Employee Diversity Team (EDT) acknowledges members of the NCI at Frederick Community for their achievements and contributions towards the mission of facility.  Historically, the team has profiled the “Women of NCI at Frederick,” but this year, the team decided to instead shed light on the diverse and successful individuals who make up the international fellows community.

  7. Overview and Utilization of the NCI Thesaurus

    Directory of Open Access Journals (Sweden)

    Larry Wright

    2006-04-01

    Full Text Available The NCI Thesaurus is a reference terminology covering areas of basic and clinical science, built with the goal of facilitating translational research in cancer. It contains nearly 110 000 terms in approximately 36000 concepts, partitioned in 20 subdomains, which include diseases, drugs, anatomy, genes, gene products, techniques, and biological processes, among others, all with a cancer-centric focus in content, and originally designed to support coding activities across the National Cancer Institute. Each concept represents a unit of meaning and contains a number of annotations, such as synonyms and preferred name, as well as annotations such as textual definitions and optional references to external authorities. In addition, concepts are modelled with description logic (DL and defined by their relationships to other concepts; there are currently approximately 90 types of named relations declared in the terminology. The NCI Thesaurus is produced by the Enterprise Vocabulary Services project, a collaborative effort between the NCI Center for Bioinformatics and the NCI Office of Communications, and is part of the caCORE infrastructure stack (http://ncicb.nci.nih.gov/NCICB/core. It can be accessed programmatically through the open caBIO API and browsed via the web (http://nciterms.nci.nih.gov. A history of editing changes is also accessible through the API. In addition, the Thesaurus is available for download in various file formats, including OWL, the web ontology language, to facilitate its utilization by others.

  8. EPI moved in beam S3

    CERN Multimedia

    1977-01-01

    The housing of the External Particle Identifier (EPI) is being moved to S3 beam. Test measurements with EPI were performed in the S3 beam between 20 and 110 GeV/c, before installing it behind BEBC. 110 GeV/c before

  9. Epi Info™ 7

    Centers for Disease Control (CDC) Podcasts

    2012-06-12

    In this podcast, Brad Myers, Director of the Division of Communication Services, talks with Asad Islam, who leads the Epi Info™ team at CDC, about Epi Info's new tools.  Created: 6/12/2012 by Office of Surveillance, Epidemiology, and Laboratory Services (OSELS).   Date Released: 1/17/2013.

  10. NCI's Distributed Geospatial Data Server

    Science.gov (United States)

    Larraondo, P. R.; Evans, B. J. K.; Antony, J.

    2016-12-01

    Earth systems, environmental and geophysics datasets are an extremely valuable source of information about the state and evolution of the Earth. However, different disciplines and applications require this data to be post-processed in different ways before it can be used. For researchers experimenting with algorithms across large datasets or combining multiple data sets, the traditional approach to batch data processing and storing all the output for later analysis rapidly becomes unfeasible, and often requires additional work to publish for others to use. Recent developments on distributed computing using interactive access to significant cloud infrastructure opens the door for new ways of processing data on demand, hence alleviating the need for storage space for each individual copy of each product. The Australian National Computational Infrastructure (NCI) has developed a highly distributed geospatial data server which supports interactive processing of large geospatial data products, including satellite Earth Observation data and global model data, using flexible user-defined functions. This system dynamically and efficiently distributes the required computations among cloud nodes and thus provides a scalable analysis capability. In many cases this completely alleviates the need to preprocess and store the data as products. This system presents a standards-compliant interface, allowing ready accessibility for users of the data. Typical data wrangling problems such as handling different file formats and data types, or harmonising the coordinate projections or temporal and spatial resolutions, can now be handled automatically by this service. The geospatial data server exposes functionality for specifying how the data should be aggregated and transformed. The resulting products can be served using several standards such as the Open Geospatial Consortium's (OGC) Web Map Service (WMS) or Web Feature Service (WFS), Open Street Map tiles, or raw binary arrays under

  11. NCI at Frederick Employees Honored at NCI Director’s Awards Program | Poster

    Science.gov (United States)

    By Nancy Parrish, Staff Writer Nineteen staff members affiliated with NCI at Frederick or the Frederick National Laboratory for Cancer Research (FNLCR) were recognized at the 2014 NCI Director’s Award Ceremony for their outstanding contributions to advancing cancer research. The ceremony, held Dec. 1, took place at the NIH Natcher Conference Center, on the main campus in Bethesda.

  12. NCI at Frederick Employees Recognized at the 2013 NCI Director’s Awards Ceremony | Poster

    Science.gov (United States)

    By Andrea Frydl, Contributing Writer, and Ashley DeVine, Staff Writer More than 60 NCI at Frederick government and contractor employees were recognized at the NCI Director’s Awards Ceremony on Nov. 14, held on the main NIH campus in Bethesda.

  13. EpiReumaPt: how to perform a national population based study – a practical guide

    Directory of Open Access Journals (Sweden)

    Nélia Gouveia

    2015-04-01

    Full Text Available Background: The aim of this article was to describe and discuss several strategies and standard operating procedures undertaken in the EpiReumaPt study – which was the first Portuguese, national, cross-sectional population-based study of Rheumatic and Musculoskeletal Diseases (RMD. Methods: The technical procedures, legal issues, management and practical questions were studied, analyzed and discussed with relevant stakeholders. During the 1st phase of EpiReumaPt the coordination team and Centro de Estudos de Sondagens e Opinião (CESOP worked to recruit and interview 10,661 subjects. The 2nd phase involved the participation of a multidisciplinary team, several local authorities, a specialized vehicle (“mobile unit” and a specific software program for the clinical appointments. The development of specific recruitment strategies improved the participation rate. Blood samples were collected and sent to Biobanco-IMM and to a central lab for immediate measurements. In the 3rd phase the RMD diagnosis were validated by a team of three experienced rheumatologists - clinical data, imaging and lab test results were revised according to previously published classification criteria. Conclusion: EpiReumaPt was a nationwide project successfully conducted, which followed critical logistic/coordination and research strategies. EpiReumaPt methodology and coordination could be used as an example for other epidemiologic endeavors and public health policies.

  14. Proceedings of the 1st LAK Data Challenge

    NARCIS (Netherlands)

    d'Aquin, Mathieu; Dietze, Stefan; Drachsler, Hendrik; Herder, Eelco; Taibi, Davide

    2013-01-01

    d'Aquin, M., Dietze, S., Drachsler, H., Herder, E., & Taibi, D. (Eds.) (2013, April). Proceedings of the 1st LAK Data Challenge, held at LAK 2013, the Third Conference on Learning Analytics and Knowledge. Published by CEUR Workshop Proceedings, 2013, Vol. 974.

  15. MULTIPLE OSSIFIED COSTAL CARTILAGES FOR 1ST RIB

    Directory of Open Access Journals (Sweden)

    Raghavendra D.R.

    2014-12-01

    Full Text Available Costal cartilages are flattened bars of hyaline cartilages. All ribs except the last two, join with the sternum through their respective costal cartilages directly or indirectly. During dissection for 1st MBBS students in the Department of Anatomy, JJMMC, Davangere, variation was found in a male cadaver aged 45 –50 years. Multiple ossified costal cartilages for 1st rib were present on left side. There were 3 costal cartilages connecting 1st rib to manubrium. There were two small intercostal spaces between them. The lower two small costal cartilages fused together to form a common segment which in turn fused with large upper costal cartilage. The large upper costal cartilage forms costochondral joint with 1st rib. All costal cartilages showed features of calcification. The present variation of multiple ossified costal cartilages are due to bifurcation of costal cartilage. It may cause musculoskeletal pain, intercostal nerve entrapment or vascular compression. Awareness of these anomalies are important for radiologists for diagnostic purpose and for surgeons for performing various clinical and surgical procedures.

  16. RESTAURANT AND CAFETERIA SERVICES ARRANGEMENTS FOR MAY 1ST, 2001

    CERN Multimedia

    Restaurant Supervisory Committee

    2001-01-01

    1. Restaurants As Tuesday, May 1st, is an official CERN holiday, restaurants no 2 (DSR : Bldg. 504 - Meyrin) and no 3 (Avenance : Bldg. 866 - Prévessin) will be closed as from Monday, April 30 at 18h00. They will reopen on Wednesday, May 2nd at 6h30 (rest. no 2) and at 7h00 (rest. no 3). On May 1st, a limited service will be provided by restaurant no. 1 (COOP : Bldg. 501 - Meyrin) from 8h00 to 21h00 with hot meals served from 11h30 to 14h00 and from 18h00 to 19h30. 2. Satellite cafétérias All satellite cafétérias will be closed on May 1st. They will all operate normally on Monday, April 30, except for buildings 17 (Meyrin), 865 and 892 (Prévessin) which will be closed. 3. Newspaper stand The newspaper kiosque in building 501 will be closed on May 1st.

  17. Evaluation of the 1st DIGIT field trial

    OpenAIRE

    Lund, Mass Soldal; Bogya, Emese Lujza

    2008-01-01

    This report evaluates the 1st DIGIT field trial, a security risk analysis conducted for Santander in the autumn of 2007. The evaluation includes lessons learned from the analysis and an empirical investigation into the use of the CORAS language in the analysis.

  18. 1st International Workshop on Learning Analytics and Linked Data

    NARCIS (Netherlands)

    Drachsler, Hendrik; Dietze, Stefan; Greller, Wolfgang; D'Aquin, Mathieu; Jovanovich, Jelena; Pardo, Abelardo; Reinhardt, Wolfgang; Verbert, Katrien

    2012-01-01

    Drachsler, H., Dietze, S., Greller, W., D'Aquin, M., Jovanovic, J., Pardo, A., Reinhardt, W., & Verbert, K. (2012). 1st International Workshop on Learning Analytics and Linked Data. In S. Dawson, C. Haythornthwaite, S. Buckingham Shum, D. Gasevic, & R. Fergusson (Eds.), LAK '12 Proceedings of the

  19. License Agreements | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    Since the government cannot engage in the development, manufacture, and sale of products, the NCI Technology Transfer Center (TTC) makes its discoveries (and discoveries from nine other NIH Institutes) available to organizations that can assist in the further development and commercialization of these basic science discoveries, to convert them into public health benefits. | [google6f4cd5334ac394ab.html

  20. At NCI, Supporting the Best Science

    Science.gov (United States)

    Yesterday, at the AACR annual meeting, Dr. Doug Lowy spoke directly to the research community about his goals as NCI Acting Director. Dr. Lowy said that he plans to continue many of the programs launched by his predecessor, Dr. Harold Varmus, and to sharp

  1. NCI and Leidos Play Ball | Poster

    Science.gov (United States)

    By Carolynne Keenan, Contributing Writer The ping of an aluminum bat off a ball or the thump of a pop-up fly ball caught in a glove are two sounds familiar to baseball fans. Slow-pitch softball sounds—like those in the August game between mixed teams of NCI and Leidos Biomedical Research (formerly SAIC-Frederick) players—are similar.

  2. NCI International EBV-Gastric Cancer Consortium

    Science.gov (United States)

    A collaboration among NCI and extramural investigators, established by DCEG in 2006, that utilizes data and biospecimens from completed and ongoing case series and observational studies of gastric cancer to replicate and extend findings from previous studies hindered by small numbers of EBV-positive cases, and to stimulate multidisciplinary research in this area.

  3. RESTAURANT and CAFETERIA SERVICES: ARRANGEMENTS for MAY 1st, 2003

    CERN Multimedia

    2003-01-01

    1. Restaurants As Thursday, May 1st, is an official CERN holiday, restaurants no. 2 (DSR : Bldg. 504 - Meyrin) and no. 3 (Avenance : Bldg. 866 - Prévessin) will be closed as from Wednesday, April 30 at 18h00. They will reopen on Friday, May 2nd at 6h30 (rest. no. 2) and at 7h00 (rest. no. 3). On May 1st, a limited service will be provided by restaurant no. 1 (COOP : Bldg. 501 - Meyrin) from 8h00 to 21h00 with hot meals served from 11h30 to 14h00 and from 18h00 to 19h30. 2. Newspaper stand The newspaper kiosque run by restaurant no. 1 in building 501 will be closed. 3. Decentralised services No decentralised services (satellite cafétérias etc.) will operate on May 1st, but will resume their normal activites on Friday, May 2nd, except for those dependent on restaurant no. 3 (Prévessin site) which will not reopen until Monday, May 5, 2003.

  4. Epi-拓扑的某些性质%Some Properties of the Epi-Topology

    Institute of Scientific and Technical Information of China (English)

    侯吉成

    2001-01-01

    Let LSC(X) denote the set of all proper lower semicontinuous functions on X with the epi-topology. In this paper we give characterizations of the separation axioms, Baire properties and metrizability of LSC(X). We show also that the continuous function space C(X) with the epi-topology is of first category when X is first countable.

  5. Going national with EPI in Nigeria.

    Science.gov (United States)

    Reid, R S; Smith, E A

    1984-01-01

    The basic purposes set out for the Owo Local Government Area (LGA) Expanded Program on Immunization (EPI) model project in Ondo State, Nigeria, were: to demonstrate in 1 LGA that 80% EPI coverage can be achieved within the resources that the government normally provides to EPI; to dispel the unquestioning acquiescence that 10-15% coverage is all that can be done; to demonstrate that the health establishment at large can be convinced of these approaches and processes and can be expected to adopt them for a much wider dissemination; to show that a substantial number of health officers and workers are willing to work toward a higher EPI achievement; and to prove that resources from various origins can be integrated given the proper operational environment and a tight organization. The problems associated with EPI are basically similar in all Nigeria, leading to the decision to undertake a model project in a selected area. The EPI project was designed to break ground in Owo for further elements of primary health care. The project's objective was to capitalize upon the success and experience in EPI to introduce other health-related and self-help activities to communities. The project was organized with an overall project director exercising broad control and supervision over a management group at the project level. The management group is made up of a project manager, an assistant project manager, and heads of functional areas such as field operation, vaccine management system, transport system, mobile operation, health education, and administration and finance. The simple organization was designed to grow gradually to meet heavier volumes of work, altering and modifying approaches as required. The 2 key technical elements in the Owo approach were greatly increased use of cold packs and a decreased reliance on refrigerators; and increased use of simple static centers to reach remote catchment areas, instead of relying heavily on the mobile units. In both elements, the

  6. [Granuloma Gravidarum in a 37-year-old 1st Gravida, 1st Para--A Case Report].

    Science.gov (United States)

    Findeklee, S

    2015-10-01

    The granuloma gravidarum is a rare benign tumour with gingival origin. It occurs in circa 0.2% of pregnancies. Mostly we see an asymptomatic course of disease terminated by hormonal changes after delivery. If the granuloma is associated with complaints of the pregnant woman, for example masticational pain or recurrent bleedings, therapeutic options are conservative therapy, surgery or delivery. We report the case of a 37-year-old 1st gravida, 1st para who had an induced delivery in the 39+2 gestational week because of a symptomatic granuloma gravidarum. We saw a spontaneous remission of the granuloma within 3 months post partum. The case report underlines the importance of suitable information for pregnant women about oral hygiene and the necessity of regular dental controls during pregnancy for prophylaxis of granuloma gravidarum.

  7. NCI at Frederick Ebola Response Team | Poster

    Science.gov (United States)

    Editor’s note: This article was adapted from the Employee Diversity Team’s display case exhibit “Recognizing the NCI at Frederick Ebola Response Team,” in the lobby of Building 549. The Poster staff recognizes that this article does not include everyone who was involved in the response to the Ebola crisis, both at NCI at Frederick and in Africa. When the Ebola crisis broke out in 2014 in West Africa, staff members from the Frederick National Laboratory for Cancer Research responded quickly. Members of the Clinical Monitoring Research Program (CMRP) were instrumental not only in setting up the clinical trials of the vaccine in Liberia, but also in providing training, community outreach, and recruitment strategies for the trials.

  8. UNC Cancer Center Director to Lead NCI.

    Science.gov (United States)

    2017-08-01

    President Donald Trump has selected Norman "Ned" Sharpless, MD, director of the University of North Carolina Lineberger Comprehensive Cancer Center, to lead the NCI. The news was met with widespread approval among cancer researchers, who view Sharpless as a strong communicator who can ably represent the needs of the cancer community in the face of proposed funding cuts. ©2017 American Association for Cancer Research.

  9. The NCI Delivery System for PDQ

    OpenAIRE

    1984-01-01

    The Physician Data Query System (PDQ) represents a major effort by the National Cancer Institute (NCI) to communicate advances in cancer treatment using computer technology. It utilizes a modern large scale computer mainframe to provide processing speed, a general purpose database management system to provide retrieval and display functions and flexibility, and commercial communications networks to provide access to an audience of physicians and other health care professionals seeking up-to-d...

  10. Stress study in 1st year medical students

    OpenAIRE

    Ranade, Amita; Kulkarni, Ganesh; Dhanumali, Sameer

    2015-01-01

    As stress is a very common feature in medical students, we performed a cross-sectional study in 1st year medical students to know the prevalence of stress in students, severity of stress & to find the symptoms associated with stress. A pre-designed & pre-tested questionnaire was distributed to 60 students (31 girls & 29 boys) randomly selected. After analyzing the data in the questionnaires, we found that major cases of stress were stress of school performance, stress of school/le...

  11. The 1st All-Russian Workshop on Archaeoastronomy

    Science.gov (United States)

    Bochkarev, Nikolai G.

    2007-08-01

    The 1st All-Russia Workshop on Archaeoastronomy “Astronomical and World-Outlook Meaning of the Archaeological Monuments of South Ural” was held on June 19-25, 2006, at the ground of the archaeological center “Arkaim” (Chelyabinsk Region). Besides about 30 talks, astronomical measurements were performed at two archaeological objects under intensive study: Arkaim Site (Bronze Epoch, XVIII-XVI c. B.C.) and tumuli “with whiskers” complex Kondurovsky (V-VIII c. A.D.). The promising character of the megalithic complex on the Vera Island (Lake Turgoyak) was stated.

  12. Proceedings of the 1st symposium on advanced science research

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    The 1st symposium on advanced science research was held in Tokai-mura, Ibaraki-ken, on 23-24 March, 1995, under the auspices of JAERI. Two hundred and sixty scientists attended the symposium; over 40% of the attendants were from universities and laboratories outside JAERI. This proceedings consists of 6 oral presentations of the research activities in the Advanced Science Research Center, 70 poster presentations on the field of basic science from both the inside and outside of JAERI and 2 panel discussions on the actinide physics and biocrystallography. (author).

  13. 2003 - 2004 ACADEMIC TRAINING PROGRAMME 1st TERM

    CERN Multimedia

    Françoise Benz

    2003-01-01

    1st TERM 29 September to 19 December 2003 REGULAR LECTURE PROGRAMME (Renewable) Energy Policy in the EU Members States and the Accession States By D. Reiche, Free University of Berlin, D 13, 14, 15, 16, 17 October LECTURES SERIES FOR POSTGRADUATE STUDENTS Introduction to QCD By B. Webber, CERN-TH 20, 21, 22, 23, 24 October The lectures are open to all those interested, without application. The abstract of the lectures, as well as any change to the above information (title, dates, time, place etc) will be published in the CERN Bulletin, the WWW, and by notices before each term and for each series of lectures.

  14. NCI's Transdisciplinary High Performance Scientific Data Platform

    Science.gov (United States)

    Evans, Ben; Antony, Joseph; Bastrakova, Irina; Car, Nicholas; Cox, Simon; Druken, Kelsey; Evans, Bradley; Fraser, Ryan; Ip, Alex; Kemp, Carina; King, Edward; Minchin, Stuart; Larraondo, Pablo; Pugh, Tim; Richards, Clare; Santana, Fabiana; Smillie, Jon; Trenham, Claire; Wang, Jingbo; Wyborn, Lesley

    2016-04-01

    The Australian National Computational Infrastructure (NCI) manages Earth Systems data collections sourced from several domains and organisations onto a single High Performance Data (HPD) Node to further Australia's national priority research and innovation agenda. The NCI HPD Node has rapidly established its value, currently managing over 10 PBytes of datasets from collections that span a wide range of disciplines including climate, weather, environment, geoscience, geophysics, water resources and social sciences. Importantly, in order to facilitate broad user uptake, maximise reuse and enable transdisciplinary access through software and standardised interfaces, the datasets, associated information systems and processes have been incorporated into the design and operation of a unified platform that NCI has called, the National Environmental Research Data Interoperability Platform (NERDIP). The key goal of the NERDIP is to regularise data access so that it is easily discoverable, interoperable for different domains and enabled for high performance methods. It adopts and implements international standards and data conventions, and promotes scientific integrity within a high performance computing and data analysis environment. NCI has established a rich and flexible computing environment to access to this data, through the NCI supercomputer; a private cloud that supports both domain focused virtual laboratories and in-common interactive analysis interfaces; as well as remotely through scalable data services. Data collections of this importance must be managed with careful consideration of both their current use and the needs of the end-communities, as well as its future potential use, such as transitioning to more advanced software and improved methods. It is therefore critical that the data platform is both well-managed and trusted for stable production use (including transparency and reproducibility), agile enough to incorporate new technological advances and

  15. myEpi. Epidemiology of one

    Directory of Open Access Journals (Sweden)

    Georgiy eBobashev

    2014-08-01

    Full Text Available A new concept of within-individual epidemiology termed myEpi is introduced. It is argued that traditional epidemiological methods, which are usually applied to populations of humans, can be applicable to a single individual and thus used for self-monitoring and forecasting of epidemic outbreaks within an individual. Traditional epidemiology requires that results be generalizable to a predefined population. The key component of myEpi is that a single individual may be viewed as an entire population of events and thus the analysis should be generalizable to this population. Applications of myEpi are aimed for, but not limited to, the analysis of data collected by individuals with the help of wearable sensors and digital diaries. These data can include physiological measures and records of healthy and risky behaviors (e.g., exercise, sleep, smoking, food consumption, alcohol and drug use. Although many examples of within-individual epidemiology exist, there is a pressing need for systematic guidance to the analysis and interpretation of intensive individual-level data. myEpi serves this need by adapting statistical methods (e.g. regressions, hierarchical models, survival analysis, agent-based models to individual-level data.

  16. myEpi. Epidemiology of One.

    Science.gov (United States)

    Bobashev, Georgiy

    2014-01-01

    A new concept of within-individual epidemiology termed "myEpi" is introduced. It is argued that traditional epidemiological methods, which are usually applied to populations of humans, can be applicable to a single individual and thus used for self-monitoring and forecasting of "epidemic" outbreaks within an individual. Traditional epidemiology requires that results be generalizable to a predefined population. The key component of myEpi is that a single individual may be viewed as an entire population of events and thus, the analysis should be generalizable to this population. Applications of myEpi are aimed for, but not limited to, the analysis of data collected by individuals with the help of wearable sensors and digital diaries. These data can include physiological measures and records of healthy and risky behaviors (e.g., exercise, sleep, smoking, food consumption, alcohol, and drug use). Although many examples of within-individual epidemiology exist, there is a pressing need for systematic guidance to the analysis and interpretation of intensive individual-level data. myEpi serves this need by adapting statistical methods (e.g., regressions, hierarchical models, survival analysis, agent-based models) to individual-level data.

  17. AIDS. 1st annual George H. Gallup Memorial Survey.

    Science.gov (United States)

    1988-06-01

    Acquired immunodeficiency syndrome (AIDS) was selected as the subject for the 1st annual George H Gallup Memorial Survey. This survey, conducted in August 1987-April 1988 in 35 countries, measured the level of awareness of AIDS, the extent of concern about AIDS, knowledge, changes in behavior resulting form the AIDS epidemic, and attitudes toward people with AIDS. Overall, the poll's findings attest to the effectiveness of the health education efforts of governmental and nongovernmental organizations. Awareness that AIDS poses an urgent international health problem was almost universal in the 35 samples. In about half of these countries, AIDS was identified as the most important national health problem; in the remaining countries, AIDS was ranked 2nd to cancer. The proportion of respondents expressing a fear of personally contracting the AIDS virus ranged from lows of under 10% in most of Europe to a high of 45% among South African blacks. A majority of respondents in the US, Colombia, the Philippines, Brazil, Nigeria, Ecuador, El Salvador, and Chile believed that AIDS will soon spread beyond current risk groups to the general population. Despite widespread awareness of the grave threat posed by AIDS, insufficient numbers of respondents reported that they had made specific behavioral changes intended to protect themselves form HIV infection. Overall, about half of those interviewed indicated they are now more cautious in their choice of sexual partners; similarly, about half are using condoms more or for the 1st time.

  18. Robust EPI Nyquist Ghost Elimination via Spatial and Temporal Encoding (EPI-GESTE)

    OpenAIRE

    Hoge, W. Scott; Tan, Huan; Kraft, Robert A.

    2010-01-01

    Nyquist ghosts are an inherent artifact in EPI acquisitions. An approach to robustly eliminate Nyquist ghosts is presented that integrates two previous Nyquist ghost correction techniques: temporal domain encoding (Phase Labeling for Additional Coordinate Encoding: PLACE) and spatial domain encoding (Phased Array Ghost Elimination: PAGE). Temporal encoding modulates the EPI acquisition trajectory from frame to frame, enabling one to interleave data to remove inconsistencies that occur between...

  19. 1st International Conference on Advancements of Medical Electronics

    CERN Document Server

    Bag, Sandip; Ganguly, Karabi; Sarkar, Indranath; Biswas, Papun

    2015-01-01

    The book is a collection of peer-reviewed scientific papers submitted by active researchers in the 1st International Conference on Advancements of Medical Electronics (ICAME2015). The conference is organized jointly by the Department of Biomedical Engineering and Electronics and Communication Engineering, JIS College of Engineering, West Bengal, India. The primary objective of the conference is to strengthen interdisciplinary research and its applications for the welfare of humanity. A galaxy of academicians, professionals, scientists, statesman and researchers from different parts of the country and abroad got together and shared their knowledge. The book presents research articles of medical image processing & analysis, biomedical instrumentation & measurements, DSP & clinical applications, embedded systems & its applications in healthcare. The book can be referred as a tool for further research.

  20. 1st Workshop of the Canadian Society for Virology

    Science.gov (United States)

    McCormick, Craig; Grandvaux, Nathalie

    2017-01-01

    The 1st Workshop of the Canadian Society for Virology (CSV2016) was a Special Workshop of the 35th Annual Meeting for the American Society for Virology, held on 18 June 2016 on the beautiful Virginia Tech campus in Blacksburg, Virginia. The workshop provided a forum for discussion of recent advances in the field, in an informal setting conducive to interaction with colleagues. CSV2016 featured two internationally-renowned Canadian keynote speakers who discussed translational virology research; American Society for Virology President Grant McFadden (then from University of Florida, now relocated to Arizona State University) who presented his studies of oncolytic poxviruses, while Matthew Miller (McMaster University) reviewed the prospects for a universal influenza vaccine. The workshop also featured a variety of trainee oral and poster presentations, and a panel discussion on the topic of the future of the CSV and virus research in Canada. PMID:28335511

  1. 1st International Conference on Communication and Computer Engineering

    CERN Document Server

    Othman, Mohd; Othman, Mohd; Rahim, Yahaya; Pee, Naim

    2015-01-01

    This book covers diverse aspects of advanced computer and communication engineering, focusing specifically on industrial and manufacturing theory and applications of electronics, communications, computing, and information technology. Experts in research, industry, and academia present the latest developments in technology, describe applications involving cutting-edge communication and computer systems, and explore likely future directions. In addition, access is offered to numerous new algorithms that assist in solving computer and communication engineering problems. The book is based on presentations delivered at ICOCOE 2014, the 1st International Conference on Communication and Computer Engineering. It will appeal to a wide range of professionals in the field, including telecommunication engineers, computer engineers and scientists, researchers, academics, and students.

  2. 1st International Conference on Calcined Clays for Sustainable Concrete

    CERN Document Server

    Favier, Aurélie

    2015-01-01

    This volume focuses on research and practical issues linked to Calcined Clays for Sustainable Concrete. The main subjects are geology of clays, hydration and performance of blended systems with calcined clays, alkali activated binders, economic and environmental impacts of the use of calcined clays in cement based materials. Topics addressed in this book include the influence of processing on reactivity of calcined clays, influence of clay mineralogy on reactivity, geology of clay deposits, Portland-calcined clay systems, hydration, durability, performance, Portland-calcined clay-limestone systems, hydration, durability, performance, calcined clay-alkali systems, life cycle analysis, economics and environmental impact of use of calcined clays in cement and concrete, and field applications. This book compiles the different contributions of the 1st International Conference on Calcined Clays for Sustainable Concrete, which took place in Lausanne, Switzerland, June, 23-25, 2015.The papers present the latest  res...

  3. 1st International Conference on Computational and Experimental Biomedical Sciences

    CERN Document Server

    Jorge, RM

    2015-01-01

    This book contains the full papers presented at ICCEBS 2013 – the 1st International Conference on Computational and Experimental Biomedical Sciences, which was organized in Azores, in October 2013. The included papers present and discuss new trends in those fields, using several methods and techniques, including active shape models, constitutive models, isogeometric elements, genetic algorithms, level sets, material models, neural networks, optimization, and the finite element method, in order to address more efficiently different and timely applications involving biofluids, computer simulation, computational biomechanics, image based diagnosis, image processing and analysis, image segmentation, image registration, scaffolds, simulation, and surgical planning. The main audience for this book consists of researchers, Ph.D students, and graduate students with multidisciplinary interests related to the areas of artificial intelligence, bioengineering, biology, biomechanics, computational fluid dynamics, comput...

  4. 1st International Conference on Robot Intelligence Technology and Applications

    CERN Document Server

    Matson, Eric; Myung, Hyun; Xu, Peter

    2013-01-01

    In recent years, robots have been built based on cognitive architecture which has been developed to model human cognitive ability. The cognitive architecture can be a basis for intelligence technology to generate robot intelligence. In this edited book the robot intelligence is classified into six categories: cognitive intelligence, social intelligence, behavioral intelligence, ambient intelligence, collective intelligence and genetic intelligence. This classification categorizes the intelligence of robots based on the different aspects of awareness and the ability to act deliberately as a result of such awareness. This book aims at serving researchers and practitioners with a timely dissemination of the recent progress on robot intelligence technology and its applications, based on a collection of papers presented at the 1st International Conference on Robot Intelligence Technology and Applications (RiTA), held in Gwangju, Korea, December 16-18, 2012. For a better readability, this edition has the total 101 ...

  5. 1st Latin American Congress on Automation and Robotics

    CERN Document Server

    Baca, José; Moreno, Héctor; Carrera, Isela; Cardona, Manuel

    2017-01-01

    This book contains the proceedings of the 1st Latin American Congress on Automation and Robotics held at Panama City, Panama in February 2017. It gathers research work from researchers, scientists, and engineers from academia and private industry, and presents current and exciting research applications and future challenges in Latin American. The scope of this book covers a wide range of themes associated with advances in automation and robotics research encountered in engineering and scientific research and practice. These topics are related to control algorithms, systems automation, perception, mobile robotics, computer vision, educational robotics, robotics modeling and simulation, and robotics and mechanism design. LACAR 2017 has been sponsored by SENACYT (Secretaria Nacional de Ciencia, Tecnologia e Inovacion of Panama).

  6. NCI Community Oncology Research Program Approved | Division of Cancer Prevention

    Science.gov (United States)

    On June 24, 2013, the National Cancer Institute (NCI) Board of Scientific Advisors approved the creation of the NCI Community Oncology Research Program (NCORP). NCORP will bring state-of-the art cancer prevention, control, treatment and imaging clinical trials, cancer care delivery research, and disparities studies to individuals in their own communities. |

  7. Information for Our Partners | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    NCI TTC CRADA PAYMENT OPTIONS: Electronic Payments by Wire Transfer via Fedwire, Mail a check to the Institute or Center, or Automated Clearing House (ACH)/Electronic Funds Transfer (ETF) payments via Pay.gov (NCI ONLY). | [google6f4cd5334ac394ab.html

  8. T1/ST2 promotes T helper 2 cell activation and polyfunctionality in bronchopulmonary mycosis.

    Science.gov (United States)

    Piehler, D; Grahnert, A; Eschke, M; Richter, T; Köhler, G; Stenzel, W; Alber, G

    2013-03-01

    Interleukin (IL)-33 enhances T helper (Th)2 immunity via its receptor T1/ST2. Infection with the yeast-like pathogen Cryptococcus neoformans is usually controlled by a Th1-mediated immune response. The mechanisms responsible for nonprotective Th2 immunity leading to allergic inflammation in pulmonary cryptococcosis are still not fully understood. Using a murine pulmonary model of C. neoformans infection, we report that T1/ST2 expression correlates with the intensity of Th2 activation, as demonstrated by the expression of CD25 and CD44 and downregulation of CD62L. Antigen-specific T1/ST2(+) Th cells are the primary source of the Th2 cytokines IL-5 and IL-13 as compared with wild-type T1/ST2(-) Th cells or Th cells from T1/ST2(-/-) mice. In addition, T1/ST2(+) Th cells almost exclusively contain bi- and trifunctional Th2 cytokine-producing Th cells compared with T1/ST2(-) Th cells or Th cells from T1/ST2(-/-) mice. Finally, T1/ST2-driven Th2 development resulted in defective pulmonary fungal control. These data demonstrate that T1/ST2 directs Th2 cell activation and polyfunctionality in allergic bronchopulmonary mycosis.

  9. 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2011-10-01

    The U.S. marine energy industry is actively pursuing development of offshore wind and marine hydrokinetic (MHK) energy systems. Experience in the wind energy sector demonstrates that new technology development requires thorough measurement and characterization of the environmental conditions prevalent at installation sites and of technology operating in the field. Presently, there are no turn-key instrumentation system solutions that meet the measurement needs of the marine energy industry. The 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop brought together technical experts from government laboratories, academia, and industry representatives from marine energy, wind, offshore oil and gas, and instrumentation developers to present and discuss the instrumentation needs of the marine energy industry. The goals of the meeting were to: 1. Share the latest relevant knowledge among technical experts; 2. Review relevant state-of-the-art field measurement technologies and methods; 3. Review lessons learned from recent field deployments; 4. Identify synergies across different industries; 5. Identify gaps between existing and needed instrumentation capabilities; 6. Understand who are the leading experts; 7. Provide a forum where stakeholders from the marine energy industry could provide substantive input in the development of new marine energy field deployable instrumentation packages.

  10. Mission & Role | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The NCI TTC serves as the focal point for implementing the Federal Technology Transfer Act to utilize patents as incentive for commercial development of technologies and to establish research collaborations and licensing among academia, federal laboratories, non-profit organizations, and industry. The TTC supports technology development activities for the National Cancer Institute and nine other NIH Institutes and Centers. TTC staff negotiate co-development agreements and licenses with universities, non-profit organizations, and pharmaceutical and biotechnology companies to ensure compliance with Federal statutes, regulations and the policies of the National Institutes of Health. TTC also reviews employee invention reports and makes recommendations concerning filing of domestic and foreign patent applications. | [google6f4cd5334ac394ab.html

  11. NCI scientists at forefront of new prostate cancer diagnostics

    Science.gov (United States)

    Introduction of the UroNav was the result of nearly a decade’s research and development, principally conducted at NCI. Resembling a stylized computer workstation on wheels, the system electronically fuses together pictures from magnetic resonance imaging

  12. Micatu Tissue Arrayer | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    An NCI researcher recognized a critical need to create a low-cost, easy-to-use tissue microarrayer (TMA), an instrument used by researchers and pathologists to accurately examine tissue samples from patients.

  13. Brenda K. Edwards, PhD | DCCPS/NCI/NIH

    Science.gov (United States)

    Brenda K. Edwards, PhD, has been with the Surveillance Research Program (SRP) and its predecessor organizations at the National Cancer Institute (NCI) since 1989, serving as SRP’s Associate Director from 1990-2011.

  14. NCI at ASCO: A brief overview on women's cancers

    Science.gov (United States)

    The 2014 annual American Society of Clinical Oncology (ASCO) meeting in Chicago in June highlighted results from a number of NCI-supported and -sponsored clinical trial results in women’s cancers. Taken together, these results represent important advances

  15. Invention Development Program Helps Nurture NCI at Frederick Technologies | Poster

    Science.gov (United States)

    The Invention Development Fund (IDF) was piloted by the Technology Transfer Center (TTC) in 2014 to facilitate the commercial development of NCI technologies. The IDF received a second round of funding from the NCI Office of the Director and the Office of Budget and Management to establish the Invention Development Program (IDP) for fiscal year 2016. The IDP is using these funds to help advance a second set of inventions.

  16. Invention Development Program Helps Nurture NCI at Frederick Technologies | Poster

    Science.gov (United States)

    The Invention Development Fund (IDF) was piloted by the Technology Transfer Center (TTC) in 2014 to facilitate the commercial development of NCI technologies. The IDF received a second round of funding from the NCI Office of the Director and the Office of Budget and Management to establish the Invention Development Program (IDP) for fiscal year 2016. The IDP is using these funds to help advance a second set of inventions.

  17. SULFATE RESISTANCE MECHANISM OF HIGH-PERFORMANCE CONCRETE CONTAINING NCI

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    It is found that the incorporation of Nitrite Corrosion Inhibitor (NCI) greatly weakens the resistance of mixtures to sulfate attack.To study the mechanism of this phenomenon,in this paper,the influence of NCI additionon on the cement paste and microstructure change of high performance concrete specimens is studied by means of quantitative XRD,SEM tests.The results demonstrate that the incorporation of NCI accelerates the formation of calcium hydroxide and ettringite crystals,and weakens the pore refinement effect caused by the secondary hydration reaction of fly ash and microsilica.At the age up to one year,the relative crystal quantity in mixture containing NCI is always higher than that in control mixture.The reasons for the degradation in sulfate resisitance of mixtures may be attributed to the increase and stability of the calcium hydroxide and ettringite crystals formed and the weakening of secondary hydration reaction.Based on the results,conclusion can be drawn that NCI should be used cautiously in practical engineering where high resistance to sulfate attack is required.

  18. An NCI perspective on creating sustainable biospecimen resources.

    Science.gov (United States)

    Vaught, Jimmie; Rogers, Joyce; Myers, Kimberly; Lim, Mark David; Lockhart, Nicole; Moore, Helen; Sawyer, Sherilyn; Furman, Jeffrey L; Compton, Carolyn

    2011-01-01

    High-quality biospecimens with appropriate clinical annotation are critical in the era of personalized medicine. It is now widely recognized that biospecimen resources need to be developed and operated under established scientific, technical, business, and ethical/legal standards. To date, such standards have not been widely practiced, resulting in variable biospecimen quality that may compromise research efforts. The National Cancer Institute (NCI) Office of Biorepositories and Biospecimen Research (OBBR) was established in 2005 to coordinate NCI's biospecimen resource activities and address those issues that affect access to the high-quality specimens and data necessary for its research enterprises as well as the broader translational research field. OBBR and the NCI Biorepository Coordinating Committee developed NCI's "Best Practices for Biospecimen Resources" after consultation with a broad array of experts. A Biospecimen Research Network was established to fund research to develop additional evidence-based practices. Although these initiatives will improve the overall availability of high-quality specimens and data for cancer research, OBBR has been authorized to implement a national biobanking effort, cancer HUman Biobank (caHUB). caHUB will address systematically the gaps in knowledge needed to improve the state-of-the-science and strengthen the standards for human biobanking. This commentary outlines the progressive efforts by NCI in technical, governance, and economic considerations that will be important as the new caHUB enterprise is undertaken.

  19. Bulletin de l'EPI n° 61 de mars 1991

    OpenAIRE

    Baudé, Jacques

    1991-01-01

    Sommaire. Bulletin de l'EPI (Enseignement Public et Informatique), (61), mars 1991. 1-2. b61p001EPI, Lucy, J., Baudé, J. (1991). Éditorial. Bulletin de l'EPI (Enseignement Public et Informatique), (61). 3-5. b61p003EPI (1991). Nous avons lu. Bulletin de l'EPI (Enseignement Public et Informatique), (61). 28-30. b61p028Chapuis, R. (1991). Entretien R. Chapuis-Médialog. Bulletin de l'EPI (Enseignement Public et Informatique), (61). 33-35. b61p033EPI (1991). Note EPI à D. Dacunha-Castelle. Bullet...

  20. Introduction to the 1st International Symposium on Phytochemicals in Medicine and Food (ISPMF 2015).

    Science.gov (United States)

    Zheng, Yafeng; Jassbi, Amir Reza; Xiao, Jianbo

    2016-03-30

    The 1st International Symposium on Phytochemicals in Medicine and Food (ISPMF 2015) was held in Shanghai, China, from June 26th to 29th, 2015. The 1st ISPMF was organized by the Phytochemical Society of Europe (PSE) and the Phytochemical Society of Asia (PSA). More than 270 scientists from 48 countries attended this meeting. The program of ISPMF 2015 consisted of 12 plenary lectures, 20 invited talks, and 55 short oral presentations in 16 sessions, including phytochemistry, phytomedicine, pharmacology, and application of phytochemicals in medicine and food. The 1st ISPMF has obtained support from Critical Reviews in Food Science and Nutrition, Food Chemistry, Phytochemistry Reviews, and Nutrients. As supported by Prof. Thomas F. Hofmann, a special issue on Journal of Agricultural and Food Chemistry (ACS) for the 1st ISPMF was initiated in January 2015.

  1. Feedback Equivalence of 1-dimensional Control Systems of the 1-st Order

    OpenAIRE

    2008-01-01

    The problem of local feedback equivalence for 1-dimensional control systems of the 1-st order is considered. The algebra of differential invariants and criteria for the feedback equivalence for regular control systems are found.

  2. A New Class of Group Field Theories for 1st Order Discrete Quantum Gravity

    OpenAIRE

    Oriti, D; Tlas, T.

    2007-01-01

    Group Field Theories, a generalization of matrix models for 2d gravity, represent a 2nd quantization of both loop quantum gravity and simplicial quantum gravity. In this paper, we construct a new class of Group Field Theory models, for any choice of spacetime dimension and signature, whose Feynman amplitudes are given by path integrals for clearly identified discrete gravity actions, in 1st order variables. In the 3-dimensional case, the corresponding discrete action is that of 1st order Regg...

  3. The NCI Digital Divide Pilot Projects: implications for cancer education.

    Science.gov (United States)

    Kreps, Gary L; Gustafson, David; Salovey, Peter; Perocchia, Rosemarie Slevin; Wilbright, Wayne; Bright, Mary Anne; Muha, Cathy

    2007-01-01

    The National Cancer Institute (NCI) supported four innovative demonstration research projects, "The Digital Divide Pilot Projects," to test new strategies for disseminating health information via computer to vulnerable consumers. These projects involved active research collaborations between the NCI's Cancer Information Service (CIS) and regional cancer control researchers to field test new approaches for enhancing cancer communication in vulnerable communities. The projects were able to use computers to successfully disseminate relevant cancer information to vulnerable populations. These demonstration research projects suggested effective new strategies for using communication technologies to educate underserved populations about cancer prevention, control, and care.

  4. File list: His.Lar.20.AllAg.1st_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Lar.20.AllAg.1st_instar dm3 Histone Larvae 1st instar SRX013009,SRX013088,SRX01...3044,SRX013064,SRX013097 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/His.Lar.20.AllAg.1st_instar.bed ...

  5. File list: His.Lar.50.AllAg.1st_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  6. File list: ALL.Lar.50.AllAg.1st_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  7. File list: His.Lar.10.AllAg.1st_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  8. File list: ALL.Lar.10.AllAg.1st_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  9. File list: ALL.Lar.20.AllAg.1st_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  10. File list: His.Lar.05.AllAg.1st_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Lar.05.AllAg.1st_instar dm3 Histone Larvae 1st instar SRX013088,SRX013009,SRX01...3064,SRX013044,SRX013097 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/His.Lar.05.AllAg.1st_instar.bed ...

  11. File list: ALL.Lar.05.AllAg.1st_instar [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  12. nucleoside DNA methyltransferase 1 inhibitors for treating epi ...

    African Journals Online (AJOL)

    Keywords: Epi-mutation, DNA methyltransferase, Non-nucleoside, DNMT1 inhibitor, Docking .... associated genes [18] and the effect could not be ... compound that may inhibit DNA methylation non- ... potential of which is over estimated [16];.

  13. Software EpiData - Applications for Needs of Biotechnological Processes

    Directory of Open Access Journals (Sweden)

    Ljakova K.

    2007-12-01

    Full Text Available EpiData (free software for entering and documenting data is presented. Some aspect of this software is shown for needs of database system (DB and information systems (IS that can be used in bioprocess system.

  14. 75 FR 4827 - Submission for OMB Review; Comment Request Clinical Trials Reporting Program (CTRP) Database (NCI)

    Science.gov (United States)

    2010-01-29

    ... of the NCI's clinical trials portfolio, which is global in nature. The response further stated that... NCI to execute its mission to reduce the burden of cancer and to ensure an optimal return on the...

  15. The Employee Invention Report (EIR) | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    After making a unique, non-obvious, and useful discovery, NIH researchers must immediately contact their Laboratory or Branch Chief and inform him or her of a possible invention, and then consult with your NCI TTC Technology Transfer Manager about submitting an Employee Invention Report (EIR) Form. | [google6f4cd5334ac394ab.html

  16. NCI Community Oncology Research Program (NCORP) | Division of Cancer Prevention

    Science.gov (United States)

    The NCI Community Oncology Research Program (NCORP) is a national network of cancer care investigators, providers, academia, and other organizations that care for diverse populations in health systems. View the list of publications from NCORP. | Clinical Trials network of cancer care professionals who care for diverse populations across the U.S.

  17. Novel Method Of Preparing Vaccines | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    This invention from the NCI Cancer and Inflammation Program describes methods to prepare vaccines for the treatment of human immunodeficiency virus (HIV) infections. The National Cancer Institute's Cancer and Inflammation Program seeks parties interested in licensing or collaborative research to further develop, evaluate, or commercialize novel methods of preparing vaccines.

  18. NCI intramural research highlighted at 2014 AACR meeting

    Science.gov (United States)

    This year’s American Association for Cancer Research meeting featured plenary talks by two NCI scientists, Steven Rosenberg, M.D., and Louis Staudt, M.D., Ph.D., that highlighted the challenges in developing varied and potentially synergistic treatments f

  19. Russian delegation visits NIH and NCI to discuss research collaboration

    Science.gov (United States)

    The NCI Center for Global Health hosted a delegation from the Russian Foundation for Basic Research to discuss ongoing and future collaborations in cancer research. The delegation was accompanied by representatives from the US Embassy in Moscow and the Embassy of the Russian Federation in Washington DC.

  20. Cancer vaccines: the perspective of the Cancer Immunology Branch, NCI.

    Science.gov (United States)

    Sogn, J A; Finerty, J F; Heath, A K; Shen, G L; Austin, F C

    1993-08-12

    The Cancer Immunology Branch, NCI, is supporting a great deal of exciting research relevant to cancer vaccine development. The few areas highlighted here are representative of ongoing research opportunities, but further progress depends largely on a continued infusion of investigator-initiated ideas to realize the potential of current research areas and open new ones.

  1. 76 FR 14034 - Proposed Collection; Comment Request; NCI Cancer Genetics Services Directory Web-Based...

    Science.gov (United States)

    2011-03-15

    ... HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request; NCI Cancer Genetics Services Directory Web-Based Application Form and Update Mailer Summary: In compliance with the requirement... included in the NCI Cancer Genetics Services Directory on NCI's Cancer.gov Web site. The...

  2. "European Resuscitation Council 2015 burn 1st Aid recommendations-concerns and issues for first responders".

    Science.gov (United States)

    Goodwin, Nicholas S

    2016-08-01

    As the lead author of a recently published systematic review on hydrogel burn dressings in pre-hospital, I was alarmed to read the claim by the authors to the effect no one method of burn wound cooling was superior to any other; "There is no evidence to recommend a specific temperature or method of cooling". The reputation and prominence of the ERC within the circle of resuscitation councils now delving into 1st Aid recommendations leads to the conclusion that misguided recommendations may cause confusion amongst first responders, may falsely misdirect 1st Aid providers to unsupported practices or alternatively create a window of opportunity for marketers or sellers of alternative burn 1st Aid technologies to make unsupported claims in respect of comparable efficacy of their own product versus "traditional" methods.

  3. A Comparative Study of Epi-up and Epi-Down Bonding of High Power 980 nm Single-Mode Semiconductor Lasers

    Institute of Scientific and Technical Information of China (English)

    Xingsheng Liu; Martin Hai Hu; Lawrence C Hughes; Hong Ky Nguyen; Catherine G. Caneau; Chung-En Zah

    2003-01-01

    Epi-up and epi-down bonding of high power 980nm lasers have been studied in terms of bonding process, thermal behavior, optical performances, thermal stress effects and long-term laser reliability. We demonstrated that epi-down bonding can offer lower thermal resistance and improved optical performances without significantly degrading the longterm laser reliability.

  4. Characteristics of fruit ripening in tomato mutant epi

    Institute of Scientific and Technical Information of China (English)

    WANG Zhong-feng; YING Tie-jin; BAO Bi-li; HUANG Xiao-dan

    2005-01-01

    The characteristics of fruit ripening and expression of ripening-related genes were investigated in epi, an ethylene overproduction mutant of tomato (Lycopersicon esculentum Mill.). The epi produces apparently more ethylene than its wild type VFN8 at every stage of vegetative and fruit growth and ripening; compared to VFN8, the epi fruit showed higher CO2 evolution,faster descending of chlorophyll, slightly quicker increase of carotenoid and lycopene, and faster reduction in pericarp firmness during maturation and ripening; and the mRNAs of three ripening-related genes including E8, pTOM5 andpTOM6 were at higher levels in epi. The ripening-related characteristics changing of the fruit are consistent with the increase of ethylene production and ripening-related genes expression. These results suggest that epi mutation possibly did not affect the ethylene perception and signaling during fruit ripening, and that the modified characteristics of fruit ripening possibly resulted from the ethylene overproduction and increased expression of ripening-related genes.

  5. Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer

    DEFF Research Database (Denmark)

    Robles, Ana I; Olsen, Karina Standahl; Tsui, Dana W T;

    2016-01-01

    The goal of biomarker research is to identify clinically valid markers. Despite decades of research there has been disappointingly few molecules or techniques that are in use today. The "1st International NTNU Symposium on Current and Future Clinical Biomarkers of Cancer: Innovation and Implement......The goal of biomarker research is to identify clinically valid markers. Despite decades of research there has been disappointingly few molecules or techniques that are in use today. The "1st International NTNU Symposium on Current and Future Clinical Biomarkers of Cancer: Innovation...

  6. Self-ratings and the Eysenck Personality Inventory (EPI).

    Science.gov (United States)

    Stones, M J

    1977-07-01

    An attempt was made to assess the relationships between self-ratings and psychometric (EPI) estimates on the dimensions of extraversion and neuroticism. Ninety-five individuals served as Ss. The correlations between self-ratings and EPI estimates achieved high significance on both dimensions. Contrary to earlier suggestions (Bem & Allen, 1974), ratings of behavioral variability on the respective dimensions failed to produce a significant moderating effect. However, a tentative trend was observed for cross-procedural comparability (between self-ratings and the EPI) to be higher near the midpoints of the respective distributions. A factor contributory to this was a central regressive tendency (noted at both poles on both dimensions and for both sources of estimation), whereby an extreme estimate from one source was associated with a less extreme estimate from the other.

  7. Doctor--how do I use my EpiPen?

    Science.gov (United States)

    Mehr, Sam; Robinson, Marnie; Tang, Mimi

    2007-08-01

    Parents and children who have been prescribed an Epipen are often unable to demonstrate its correct administration. One contributory factor may be that doctors are unfamiliar with the EpiPen and are unable to demonstrate the correct administration of the pen to the family. The aim of this study was to determine the rate of correct EpiPen demonstration by junior and Senior Medical Staff at a major tertiary paediatric Hospital. Junior and Senior medical staff were scored on their ability to correctly use the EpiPen trainer. A 6 step scoring system was used. One-hundred doctors were recruited (Residents n = 31, Senior Residents n = 39, Fellow/Consultants n = 30). Junior and Senior Medical staff had similar scores for EpiPen demonstration, the number that needed to read the EpiPen instructions prior to use and the frequancy of accidental self-injection into the thumb. Only two doctors (2%) demonstrated all 6 administration steps correctly. The most frequent errors made were not holding the pen in place for >5 seconds (57%), failure to apply pressure to activate (21%), and self-injection into the thumb (16%). Ninety five doctors needed to read the instructions, and of these, only 39 (41%) then proceeded to correctly demonstrate the remaining 5 steps. Forty-five doctors had previously dispensed an EpiPen, but only three demonstrated its use to parents/children with a trainer. The majority of doctors do not know how to use an Epipen and are unable to provide appropriate education to parents/children. In 37% of cases, the demonstration would not have delivered adrenaline to a patient.

  8. NCI Updates Tobacco Policies Following Re-accreditation | Poster

    Science.gov (United States)

    This year, NCI was re-accredited as one of nearly 200 CEO Cancer Gold Standard employers across the United States. According to its website, “the CEO Cancer Gold Standard provides a framework for employers to have a healthier workplace by focusing on cancer risk reduction, early detection, and access to clinical trials and high-quality care.” As part of this re-accreditation, NCI has updated its Tobacco-Free Policy. Part of this policy includes posting signs around campus reminding visitors and staff that NCI’s campus is tobacco-free. Therefore, the use of all tobacco products is prohibited. This includes cigarettes, cigars, pipes, e-cigarettes, and smokeless tobacco.

  9. Regular paths in SparQL: querying the NCI Thesaurus.

    Science.gov (United States)

    Detwiler, Landon T; Suciu, Dan; Brinkley, James F

    2008-11-06

    OWL, the Web Ontology Language, provides syntax and semantics for representing knowledge for the semantic web. Many of the constructs of OWL have a basis in the field of description logics. While the formal underpinnings of description logics have lead to a highly computable language, it has come at a cognitive cost. OWL ontologies are often unintuitive to readers lacking a strong logic background. In this work we describe GLEEN, a regular path expression library, which extends the RDF query language SparQL to support complex path expressions over OWL and other RDF-based ontologies. We illustrate the utility of GLEEN by showing how it can be used in a query-based approach to defining simpler, more intuitive views of OWL ontologies. In particular we show how relatively simple GLEEN-enhanced SparQL queries can create views of the OWL version of the NCI Thesaurus that match the views generated by the web-based NCI browser.

  10. Synthesis of 7,8-epi-Valtrate from (+)-Genipin

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Sangtae; Kwon, Daeho; Shin, WoonSeob; Ham, Jungyeob; Lee, Seokjoon [Kwandong Univ. College of Medicine, Gangneung (Korea, Republic of)

    2012-12-15

    In conclusion, we synthesized 7,8-epi-valtrate (6) from (+)-genipin (8). Although final product 6 has the opposite stereochemistry at C-7 and 8 compared to natural valtrate (5), this is the first synthesis of a diene-type valepotriate epimeric structure by an efficient synthetic pathway. We screened the compounds for proliferation inhibition of various cancer cell lines and HUVEC and discovered 7,8-epi-valtrate (6) and its synthetic intermediates showed strong inhibitory activity; these results will be published elsewhere.

  11. epiGBS: reference-free reduced representation bisulfite sequencing.

    Science.gov (United States)

    van Gurp, Thomas P; Wagemaker, Niels C A M; Wouters, Björn; Vergeer, Philippine; Ouborg, Joop N J; Verhoeven, Koen J F

    2016-04-01

    We describe epiGBS, a reduced representation bisulfite sequencing method for cost-effective exploration and comparative analysis of DNA methylation and genetic variation in hundreds of samples de novo. This method uses genotyping by sequencing of bisulfite-converted DNA followed by reliable de novo reference construction, mapping, variant calling, and distinction of single-nucleotide polymorphisms (SNPs) versus methylation variation (software is available at https://github.com/thomasvangurp/epiGBS). The output can be loaded directly into a genome browser for visualization and into RnBeads for analysis of differential methylation.

  12. 1st and 2nd Trimester Headsize in Fetuses with Congenital Heart Disease: A Cohort Study

    DEFF Research Database (Denmark)

    Lauridsen, Mette Høj; Petersen, Olav Bjørn; Vestergaard, Else Marie

    2014-01-01

    208 fetuses (75%) with presumed non-syndromic CHD were included, 85 (41%) with minor and 123 (59%) with major CHD. Z-scores for head size were analysed. Conclusions: Our preliminary results suggest that Bi-parietal-diameter in children with CHD is within the normal range in the 1st trimester...

  13. The Course of Psychological Disorders in the 1st Year After Cancer Diagnosis

    Science.gov (United States)

    Kangas, Maria; Henry, Jane L.; Bryant, Richard A.

    2005-01-01

    This study investigated the relationship between acute stress disorder (ASD) and posttraumatic stress disorder (PTSD) and comorbid anxiety, depressive, and substance use disorders over the first 12-month period following a cancer diagnosis. Individuals recently diagnosed with 1st onset head and neck or lung malignancy were assessed for ASD within…

  14. 1st ESMO Consensus Conference in lung cancer; Lugano 2010: small-cell lung cancer

    DEFF Research Database (Denmark)

    Stahel, R; Thatcher, N; Früh, M;

    2011-01-01

    The 1st ESMO Consensus Conference on lung cancer was held in Lugano, Switzerland on 21st and 22nd May 2010 with the participation of a multidisciplinary panel of leading professionals in pathology and molecular diagnostics and medical, surgical and radiation oncology. Before the conference, the e...

  15. Perspective through the 1st class innovation award-innovation in the key materials

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Directed by Prof.Litong Zhang (Member of CAS)from Northwestern Polytechnical University, the project on the topic of ceramic matrix composite, which sustains high temperature, resists oxidization, and has a long lifetime,achieved the 1st class National Technology Innovation Award in 2004.

  16. Complex brackets and balanced complex 1st-order difference polynomials in 4-dimensional Minkowski space

    Institute of Scientific and Technical Information of China (English)

    HUANG Lei; LI HongBo

    2008-01-01

    This paper investigates complex brackets and balanced complex 1st-order difference (BCD) polynomials. Then we propose an algorithm of O(nlog n) complexity to check the equality of brackets. It substitutes exponential algorithms before. Also, BCD polynomials have some usages in geometric calculation.

  17. Complex brackets and balanced complex 1st-order difference polynomials in 4-dimensional Minkowski space

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    This paper investigates complex brackets and balanced complex 1st-order di?erence (BCD) polynomials. Then we propose an algorithm of O(n log n) complexity to check the equality of brackets. It substitutes exponential algorithms before. Also, BCD polynomials have some usages in geometric calculation.

  18. How Many Attempts Until Success in Some Core 1st. Year Disciplines?

    Science.gov (United States)

    Fernandes, Graça Leão; Andrade e Silva, João; Lopes, Margarida Chagas

    2012-01-01

    Due to a general development in education brought about by democracy, Portugal has witnessed tremendous development in Higher Education (HE) since the beginning of the 1980s. Nevertheless, the percentage of graduates among the Portuguese population still ranks far below most European countries. This is why academic performance in HE 1st cycle…

  19. Proceedings of the 1st Workshop on Technology Support for Self-Organized Learners

    NARCIS (Netherlands)

    Kalz, Marco; Koper, Rob; Hornung-Prähauser, Veronika; Luckmann, Michaela

    2008-01-01

    Kalz, M., Koper, R., Hornung-Prähauser, V., & Luckmann, M. (Eds.) (2008). Proceedings of the 1st Workshop on Technology Support for Self-Organized Learners. June, 2-3, 2008, Salzburg, Austria: CEUR Workshop Proceedings, ISSN 1613-0073. Available at http://ceur-ws.org/Vol-349.

  20. Proceedings of the 1st workshop on aspect reverse-engineering, Delft, 09.11.2004

    NARCIS (Netherlands)

    Tourwé, T.; Bruntink, M.; Marin, A.M.; Shepherd, D.

    2005-01-01

    This technical report contains the papers submitted to and presented at the 1st Workshop on Aspect Reverse-Engineering, held in conjunction with the 11th Working Conference on Reverse Engineering (WCRE), in Delft, The Netherlands. The aims of this workshop was to bring together researchers and pract

  1. NCI at Frederick Scientific Library Reintroduces Scientific Publications Database | Poster

    Science.gov (United States)

    A 20-year-old database of scientific publications by NCI at Frederick, FNLCR, and affiliated employees has gotten a significant facelift. Maintained by the Scientific Library, the redesigned database—which is linked from each of the Scientific Library’s web pages—offers features that were not available in previous versions, such as additional search limits and non-traditional metrics for scholarly and scientific publishing known as altmetrics.

  2. ``Thatcher's Ghost'': Confirmation of the ν Cygnids (NCY, IAU #409)

    Science.gov (United States)

    Jenniskens, Peter; Haberman, Bob

    2013-06-01

    A ghostly image of meteor radiants appeared in the CAMS data north-east of the Lyrids on April 22, 2012. The diffuse shower is identified as the ν Cygnids (NCY). It is weakly active from April 17 to 26, and likely related to the April ρ Cygnids (ARC), active in the area after April 27. The ν Cygnids may have been in outburst in 2012, because this shower was not as evident in the 2007-2011 SonotaCo data.

  3. NCI investment in nanotechnology: achievements and challenges for the future.

    Science.gov (United States)

    Dickherber, Anthony; Morris, Stephanie A; Grodzinski, Piotr

    2015-01-01

    Nanotechnology offers an exceptional and unique opportunity for developing a new generation of tools addressing persistent challenges to progress in cancer research and clinical care. The National Cancer Institute (NCI) recognizes this potential, which is why it invests roughly $150 M per year in nanobiotechnology training, research and development. By exploiting the various capacities of nanomaterials, the range of nanoscale vectors and probes potentially available suggests much is possible for precisely investigating, manipulating, and targeting the mechanisms of cancer across the full spectrum of research and clinical care. NCI has played a key role among federal R&D agencies in recognizing early the value of nanobiotechnology in medicine and committing to its development as well as providing training support for new investigators in the field. These investments have allowed many in the research community to pursue breakthrough capabilities that have already yielded broad benefits. Presented here is an overview of how NCI has made these investments with some consideration of how it will continue to work with this research community to pursue paradigm-changing innovations that offer relief from the burdens of cancer.

  4. Analysis of Historical Materiel Return Program (MRP) Credits at the 1st Marine Logistics Group Reparable Issue Point (RIP)

    Science.gov (United States)

    2011-12-01

    MATERIEL RETURN PROGRAM ( MRP ) CREDITS AT THE 1ST MARINE LOGISTICS GROUP REPARABLE ISSUE POINT (RIP) by Edward M. Caricato John D. Draper...Materiel Return Program ( MRP ) Credits at the 1st Marine Logistics Group Reparable Issue Point (RIP) 6. AUTHOR(S) Edward M. Caricato and John D. Draper...unlimited 12b. DISTRIBUTION CODE A 13. ABSTRACT (maximum 200 words) Materiel Returns Program ( MRP ) credits have increased 1st Marine

  5. Report on: "The 1st Workshop on National Immunization Programs and Vaccine Coverage in ASEAN Countries, April 30, 2015, Pattaya, Thailand".

    Science.gov (United States)

    Hattasingh, Weerawan; Pengsaa, Krisana; Thisyakorn, Usa

    2016-03-04

    The 1st Workshop on National Immunization Programs and Vaccine Coverage in Association of Southeast Asian Nations (ASEAN) Countries Group (WNIPVC-ASEAN) held a meeting on April 30, 2015, Pattaya, Thailand under the auspices of the Pediatric Infectious Diseases Society and the World Health Organization (WHO). Reports on the current status and initiatives of the national immunization program (NIP) in each ASEAN countries that attended were presented. These reports along with survey data collected from ministries of health in ASEAN countries NIPs demonstrate that good progress has been made toward the goal of the Global Vaccine Action Plan (GVAP). However, some ASEAN countries have fragile health care systems that still have insufficient vaccine coverage of some basic EPI antigens. Most ASEAN countries still do not have national coverage of some new and underused vaccines, and raising funds for the expansion of NIPs is challenging. Also, there is insufficient research into disease burden of vaccine preventable diseases and surveillance. Health care workers must advocate NIPs to government policy makers and other stakeholders as well as improve research and surveillance to achieve the goals of the GVAP.

  6. Collaboration Opportunities with the Cancer Human Biobank (caHUB) at NCI | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The Biorepositories and Biospecimen Research Branch (BBRB) at the National Cancer Institute has developed the Cancer Human Biobank (caHUB), which is a unique infrastructure for collecting biospecimens for the purpose of conducting biospecimen research. Biospecimens from the BPV program will be made available to collaborators with the capability to perform molecular analysis as part of a collaborative research agreement with the NCI-BBRB.

  7. epi-Aszonalenins A, B, and C from Aspergillus novofumigatus

    DEFF Research Database (Denmark)

    Rank, Christian; Phipps, Richard Kerry; Harris, Pernille

    2006-01-01

    Three new benzodiazepines have been isolated from an unusual chemotype of Aspergillus novofumigatus: epi-aszonalenins A, B, and C. The structures were elucidated by use of one- and two-dimensional NMR spectroscopic techniques and HR ESI MS. The relative configuration was established on the basis...

  8. EpiJSON: A unified data-format for epidemiology.

    Science.gov (United States)

    Finnie, Thomas J R; South, Andy; Bento, Ana; Sherrard-Smith, Ellie; Jombart, Thibaut

    2016-06-01

    Epidemiology relies on data but the divergent ways data are recorded and transferred, both within and between outbreaks, and the expanding range of data-types are creating an increasingly complex problem for the discipline. There is a need for a consistent, interpretable and precise way to transfer data while maintaining its fidelity. We introduce 'EpiJSON', a new, flexible, and standards-compliant format for the interchange of epidemiological data using JavaScript Object Notation. This format is designed to enable the widest range of epidemiological data to be unambiguously held and transferred between people, software and institutions. In this paper, we provide a full description of the format and a discussion of the design decisions made. We introduce a schema enabling automatic checks of the validity of data stored as EpiJSON, which can serve as a basis for the development of additional tools. In addition, we also present the R package 'repijson' which provides conversion tools between this format, line-list data and pre-existing analysis tools. An example is given to illustrate how EpiJSON can be used to store line list data. EpiJSON, designed around modern standards for interchange of information on the internet, is simple to implement, read and check. As such, it provides an ideal new standard for epidemiological, and other, data transfer to the fast-growing open-source platform for the analysis of disease outbreaks.

  9. A Novel Synthesis of (-)-10-epi-α-Cyperone

    Institute of Scientific and Technical Information of China (English)

    Li Jing FANG; Jin Chun CHEN; Guo Jun ZHENG; Yu Kun GUAN; Yu Lin LI

    2004-01-01

    An alternative route for the synthesis of (-)-10-epi-α-cyperone 1 starting from (+)- dihydrocarvone 2 is described by using an asymmetric Michael addition as a key step. The route features more efficiently and can be performed in large scale.

  10. Synthesis of ()-albrassitriol and ()-6-epi-albrassitriol from (+)-larixol

    NARCIS (Netherlands)

    Vlad, P.F.; Ciocarlan, A.; Coltsa, M.; Edu, C.; Biriiac, A.; Barba, A.; Deleanu, C.; Nicolescu, A.; Ambrosio, D' M.; Groot, de Æ.

    2013-01-01

    A novel synthesis of natural drimanic compounds, ()-albrassitriol (2) and ()-6-epi-albrassitriol (3), has been carried out starting from an easily available labdane diterpenoid, (+)-larixol (1). In a two-step procedure, (+)-larixol (1) was converted into 14,15-bisnorlab-7-ene-6,13-dione (9), which w

  11. EpiAssist: Service-learning in public health education.

    Science.gov (United States)

    Horney, Jennifer A; Bamrara, Sanjana; Macik, Maria Lazo; Shehane, Melissa

    2016-01-01

    Although public health degree programs typically require practica and other field experiences, service-learning courses, with a focus on civic engagement and the application of classroom learning in real world settings, can go beyond these requirements and provide benefits to students and community-based practice partners. The goal of this paper is to assess potential benefits of service-learning programs for both graduate-level public health students and state and local public health agency partners. EpiAssist is a new service-learning program developed at the School of Public Health of the Texas A and M University Health Science Center, USA, in January 2015. EpiAssist was integrated into a new course, Methods in Field Epidemiology. The integration of service-learning was guided by a partnership with the Texas A and M Center for Teaching Excellence. State, regional, and local public health partners requested EpiAssist via email or telephone. A listserv was used to recruit student volunteers to meet requests. 54 of 86 registered EpiAssist students (63%) participated in at least one of ten service-learning and three training activities between January and June, 2015. Service-learning activities included questionnaire development, in-person and telephone data collection, and data analysis. Training topics for students included the Epi Info™ software, community assessment and communicable disease reporting. Students and partner organizations provided generally positive assessments of this service learning program through an online evaluation. Service-learning provides students with enhanced classroom learning through applied public health experience in state, regional and local health departments. These experiences provide both needed surge capacity to public health departments and valuable hands-on field experience to students.

  12. NCI Scientists Awarded National Medal of Technology and Innovation by President Obama | Poster

    Science.gov (United States)

    Two NCI scientists received the National Medal of Technology and Innovation, the nation’s highest honor for technological achievement. The award was announced by President Obama in October. The honorees, John Schiller, Ph.D., Laboratory of Cellular Oncology (LCO), Center for Cancer Research, NCI, and Douglas Lowy, M.D., also from LCO and NCI deputy director, received their medals at a White House ceremony on Nov. 20.

  13. Proceedings of the 1st Nordic Optimization Symposium - 10th Nordic MPS meeting, Copenhagen 2006

    DEFF Research Database (Denmark)

    Clausen, Jens; Jørgensen, Rene Munk; Kohl, Niklas;

    2006-01-01

    On behalf of the Technical University of Denmark, the Danish Operations Research Society and the Nordic Section of the Mathematical Programming Society we welcome you to Copenhagen and the 1st Nordic Optimization Symposium - the 10th meeting of the Nordic MPS. The meetings of the Nordic MPS have...... an enjoyable 1st Nordic Optimization Symposium (10th Nordic MPS meeting) in Copenhagen....... to add a new title, that reflects the much broader field that is our playground at these meetings. Still the odd trustworthy title “Meeting of the Nordic MPS” has been maintained to demonstrate the origin of the symposium. It is our hope that future Nordic MPS meetings will carry on using this “double...

  14. The 1st of April 2470 BC Total Solar Eclipse Seen by the Prophet Ibraheem

    Science.gov (United States)

    Yousef, S. M.

    The Holy Quran describes a phenomenon seen by young Abraham that can only fit a solar eclipse. Two criteria were given for this particular eclipse; first only one planet was seen as soon as it got dark and second no corona was seen. In order to justify the first selection rule, examinations of solar and planetary longitudes for total solar eclipses passing over Babel were carried out. Only the eclipse of the 1st of April 2470 BC meets this condition, as it was only Venus that was seen at that eclipse. The second selection rule was also naturally fulfilled, as Babel happened to be on the border of the totality zone hence no corona was seen, however all the time the moon glistened as Baily's beads. There is no doubt that the prophet Abraham witnessed the 1st of April total solar eclipse that passed over Babel. This will put him about 470 years backward than it was previously anticipated.

  15. Proceedings of the 1st CIRP Seminar on Micro and Nano Technology

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Alting, Leo

    2003-01-01

    The present Proceedings of the 1st International CIRP Seminar on Micro and Nano Technology is the result of a CIRP initiative taken by the Working Group on Micro/Nano Technology established in 2002. The CIRP initiative is a recognition of the large potentials that micro/nano technology has...... in improving/enhancing many of the existing products and in forming the basis of a long range of new next generation of products. Micro and nano technology are common phrases used to describe phenomena, components, products etc. related to small dimensions, usually based on functioning principles...... accessible to a large group of customers. Therefore, product development and manufacture is very essential. Therefore this 1st CIRP Seminar represents an important milestone for design and industrial manufacture of products based on micro and nano technology. The Proceedings cover mostly new, interesting...

  16. Idaho National Laboratory Quarterly Performance Analysis - 1st Quarter FY2015

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Lisbeth A. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 73 reportable events (27 from the 1St Qtr FY-15 and 46 from the prior three reporting quarters), as well as 38 other issue reports (including nine not reportable events and Significant Category A and B conditions reported during the1st Qtr FY-15) identified at INL during the past 12 months.

  17. A New Class of Group Field Theories for 1st Order Discrete Quantum Gravity

    CERN Document Server

    Oriti, Daniele

    2007-01-01

    Group Field Theories, a generalization of matrix models for 2d gravity, represent a 2nd quantization of both loop quantum gravity and simplicial quantum gravity. In this paper, we construct a new class of Group Field Theory models, for any choice of spacetime dimension and signature, whose Feynman amplitudes are given by path integrals for clearly identified discrete gravity actions, in 1st order variables. In the 3-dimensional case, the corresponding discrete action is that of 1st order Regge calculus for gravity (generalized to include higher order corrections), while in higher dimensions, they correspond to a discrete BF-theory (again, generalized to higher order) with an imposed orientation restriction on hinge volumes, similar to that characterizing discrete gravity. The new models shed also light on the large distance or semi-classical approximation of spin foam models. This new class of group field theories may represent a concrete unifying framework for loop quantum gravity and simplicial quantum grav...

  18. Development of repair mechanism of FSX-414 based 1st stage nozzle of gas turbine

    Science.gov (United States)

    Rahman, Md. Tawfiqur

    2017-06-01

    This paper describes the failure mechanism and repair technology of 1st stage nozzle or vane of industrial gas turbine which is made of cobalt based super alloy FSX-414. 1st stage nozzles or vanes are important stationery components of gas turbine based power plant. Those are the parts of hot gas path components of gas turbine and their manufacturing process is casting. At present, it is widely accepted that gas turbine based combined cycle power plant is the most efficient and cost effective solution to generate electricity. One of the factors of high efficiency of this type of gas turbine is the increase of its turbine inlet temperature. As an effect of this factor and in conjunction with some other factors, the 1st stage nozzle of gas turbine operates under extremely high temperature and thermal stresses. As a result, the design lifetime of these components becomes limited. Furthermore, attention on nozzles or vanes is required in order to achieve their design lifetime. However, due to unfriendly operational condition and environmental effect, anytime failure can occur on these heat resistant alloy based components which may lead to severe damage of gas turbine. To mitigate these adverse effects, schedule maintenance is performed on a predetermined time interval of hot gas path components of gas turbine based power plant. This paper addresses common failures in gas turbine's 1st stage nozzles or vanes. Usually these are repaired by using ADH process but for several reasons ADH process is not used here. Hence the challenging task is performed using gas tungsten arc welding which is presented in this article systematically.

  19. Aedes aegypti pharate 1st instar quiescence affects larval fitness and metal tolerance.

    Science.gov (United States)

    Perez, Mario H; Noriega, Fernando G

    2012-06-01

    The eggs of the mosquito Aedes aegypti possess the ability to undergo an extended quiescence hosting a fully developed 1st instar larvae within the chorion. As a result of this life history trait pharate larvae can withstand months of quiescence inside the egg where they depend on stored maternal reserves. A. aegypti mosquitoes are frequently associated with urban habitats that may contain significant metal pollution. Therefore, the duration of quiescence and extent of nutritional depletion may affect the physiology and survival of larvae that hatch in a suboptimal habitat. The aim of this study was to determine the effect of an extended quiescence on larval nutrient reserves and the subsequent effects of metal exposure on larval fitness, survival and development. We hypothesized that an extended quiescence would reduce nutritional reserves and alter the molecular response to metal exposure thereby reducing larval survival and altering larval development. As a molecular marker for metal stress responses, we evaluated transcriptional changes in the metallothionein gene (AaMtn) in response to quiescence and metal exposure. Extended 1st instar quiescence resulted in a significant decrease in lipid reserves and negatively affected larval fitness and development. AaMtn transcription and metal tolerance were compromised in first instars emerged from eggs that had undergone an extended quiescence. These findings suggest that newly emerged mosquito larvae that had survived a relatively long pharate 1st instar quiescence (as might occur during a dry season) are more vulnerable to environmental stress. Pharate 1st instar quiescence could have implications for vector control strategies. Newly emerged mosquito larvae at the end of the dry season or start of the wet season are physiologically compromised, and therefore potentially more susceptible to vector control strategies than mosquito larvae hatched subsequently throughout the wet season. Published by Elsevier Ltd.

  20. 1st Cavalry Division’s Effectiveness In Conducting Airmobile Operations During Operation Pegasus

    Science.gov (United States)

    2016-05-26

    assault, OH-6 Cayuse scout helicopters and AH­ 1G Cobra attack helicopters from the cavalry scoured the area at low altitude , collected intelligence...Lieutenant General John Tolson, the division commander, drew-up initial plans to relieve the Marines at Khe Sanh on January 25, 1968.13 When he briefed...Cavalry Division to relieve Khe Sanh. 64 The Rogers Board began the development of the aircraft that would make 1st Cavalry Division successful by

  1. Ruthenium indenylidene “1st generation” olefin metathesis catalysts containing triisopropyl phosphite

    Directory of Open Access Journals (Sweden)

    Stefano Guidone

    2015-09-01

    Full Text Available The reaction of triisopropyl phosphite with phosphine-based indenylidene pre-catalysts affords “1st generation” cis-complexes. These have been used in olefin metathesis reactions. The cis-Ru species exhibit noticeable differences with the trans-Ru parent complexes in terms of structure, thermal stability and reactivity. Experimental data underline the importance of synergistic effects between phosphites and L-type ligands.

  2. Ruthenium indenylidene "1(st) generation" olefin metathesis catalysts containing triisopropyl phosphite.

    Science.gov (United States)

    Guidone, Stefano; Nahra, Fady; Slawin, Alexandra M Z; Cazin, Catherine S J

    2015-01-01

    The reaction of triisopropyl phosphite with phosphine-based indenylidene pre-catalysts affords "1(st) generation" cis-complexes. These have been used in olefin metathesis reactions. The cis-Ru species exhibit noticeable differences with the trans-Ru parent complexes in terms of structure, thermal stability and reactivity. Experimental data underline the importance of synergistic effects between phosphites and L-type ligands.

  3. Ruthenium indenylidene “1st generation” olefin metathesis catalysts containing triisopropyl phosphite

    Science.gov (United States)

    Guidone, Stefano; Nahra, Fady; Slawin, Alexandra M Z

    2015-01-01

    Summary The reaction of triisopropyl phosphite with phosphine-based indenylidene pre-catalysts affords “1st generation” cis-complexes. These have been used in olefin metathesis reactions. The cis-Ru species exhibit noticeable differences with the trans-Ru parent complexes in terms of structure, thermal stability and reactivity. Experimental data underline the importance of synergistic effects between phosphites and L-type ligands. PMID:26425210

  4. Perception of 1 st year medical students towards career choices and specialty of psychiatry

    OpenAIRE

    Suneet Kumar Upadhyaya; Chintan M Raval

    2015-01-01

    Background: Shortage of psychiatrists is a worldwide phenomenon. If the factors that attract or repel students towards a specialty can be identified, it may be possible to encourage them towards it. Choice of specialty as a career depends on the complex interplay of experiences before, during or after exposure to the specialty. Objectives: The aim was to understand perceptions of 1 st year medical students regarding career choices and the specialty of psychiatry through a cross-sectional ...

  5. 1st Meeting of China-ROK Eligibility Assessment Subcommittee Held in Beijing

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ The 1st Meeting of China-ROK Eligibility Assessment Subcommittee was held in Beijing on May 27. Sun Dawei, Chief Chinese representative and Certification and Accreditation Administration of China (CNCA)Deputy Director of presided over the meeting and Hong Zong, Chief ROK representative and Director of Security Service Standard Department of Technology Standard Institute of the Ministry of Industrial Resources of the Republic of Korea led a delegation to Beijing for the meeting.

  6. Magnetic field induced 1st order transitions: Recent studies, and some new concepts

    Science.gov (United States)

    Chaddah, P.

    2015-05-01

    Phase transitions are caused by varying temperature, or pressure, or magnetic field. The observation of 1st order magneto-structural transitions has created application possibilities based on magnetoresistance, magnetocaloric effect, magnetic shape memory effect, and magneto-dielectric effect. Magnetic field induced transitions, and phase coexistence of competing magnetic phases down to the lowest temperature, gained prominence over a decade ago with theoretical models suggesting that the ground state is not homogeneous. Researchers at Indore pushed an alternative view that this phase coexistence could be due to glasslike "kinetic arrest" of a disorder-broadened first-order magnetic transition between two states with long-range magnetic order, resulting in phase coexistence down to the lowest temperatures. The CHUF (cooling and heating in unequal field) protocol created at Indore allows the observation of `devitrification', followed by `melting'. I show examples of measurements establishing kinetic arrest in various materials, emphasizing that glasslike arrest of 1st order magnetic transitions may be as ubiquitous as glass formation following the arrest of 1st order structural transitions.

  7. File list: Unc.PSC.10.AllAg.EpiLC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.10.AllAg.EpiLC mm9 Unclassified Pluripotent stem cell EpiLC SRX1074910,SRX1...074907 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.10.AllAg.EpiLC.bed ...

  8. File list: Unc.PSC.05.AllAg.EpiLC [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  9. File list: Unc.PSC.50.AllAg.EpiLC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.50.AllAg.EpiLC mm9 Unclassified Pluripotent stem cell EpiLC SRX1074910,SRX1...074907 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.50.AllAg.EpiLC.bed ...

  10. File list: Unc.PSC.20.AllAg.EpiLC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.20.AllAg.EpiLC mm9 Unclassified Pluripotent stem cell EpiLC SRX1074910,SRX1...074907 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.20.AllAg.EpiLC.bed ...

  11. File list: InP.PSC.10.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  12. File list: InP.PSC.50.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  13. File list: InP.PSC.20.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  14. File list: His.PSC.10.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  15. File list: Unc.PSC.05.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 074908,SRX1074905 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.05.AllAg.EpiSC.bed ... ...Unc.PSC.05.AllAg.EpiSC mm9 Unclassified Pluripotent stem cell EpiSC SRX1074917,SRX1

  16. File list: His.PSC.50.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  17. File list: InP.PSC.05.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  18. File list: Unc.PSC.50.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  19. File list: His.PSC.05.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  20. File list: Unc.PSC.20.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  1. File list: His.PSC.20.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  2. EpiNet : Revue électronique de l'EPI, Année 2009, n° 111-120

    OpenAIRE

    Archambault, Jean-Pierre

    2009-01-01

    Tous les articles sont accessibles via le fichier attaché index.html. EPI, Archambault, J.-P. (2009). Éditorial : Du temps donné pour la mise en place d'un enseignement de l'informatique et des TIC au Lycée. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), jan. 2009, (111). a0901d EPI, Archambault, J.-P. (2009). Comment donner une culture générale informatique à tous les élèves ? Compte-rendu de la table ronde EPI au salon Educatice. EpiNet : Revue électronique de ...

  3. Vaccines for HIV | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The development of an effective HIV vaccine has been an ongoing area of research. The high variability in HIV-1 virus strains has represented a major challenge in successful development. Ideally, an effective candidate vaccine would provide protection against the majority of clades of HIV. Two major hurdles to overcome are immunodominance and sequence diversity. This vaccine utilizes a strategy for overcoming these two issues by identifying the conserved regions of the virus and exploiting them for use in a targeted therapy. NCI seeks licensees and/or research collaborators to commercialize this technology, which has been validated in macaque models.

  4. NCI at Frederick Employees Sew for Cancer | Poster

    Science.gov (United States)

    By Carolynne Keenan, Contributing Writer The R&W Club Frederick hosted a sewing party on Feb. 18 to give employees a chance to help sew pillowcases for children hospitalized for illnesses and cancer treatments. The nonprofit organization ConKerr Cancer provides the pillowcases to children across the country. Melissa Porter, administrative manager, Office of Scientific Operations, NCI at Frederick, and vice chair of the R&W Club Frederick, said the event went well. While the turnout was lower than expected, 27 pillowcases were completed, she said.

  5. New Phone System Coming to NCI Campus at Frederick | Poster

    Science.gov (United States)

    By Travis Fouche and Trent McKee, Guest Writers Beginning in September, phones at the NCI Campus at Frederick will begin to be replaced, as the project to upgrade the current phone system ramps up. Over the next 16 months, the Information Systems Program (ISP) will be working with Facilities Maintenance and Engineering and Computer & Statistical Services to replace the current Avaya phone system with a Cisco Unified Communications phone system. The Cisco system is already in use at the Advanced Technology Research Facility (ATRF).

  6. Tako-tsubo-like cardiomyopathy after EpiPen administration.

    Science.gov (United States)

    Zubrinich, C M; Farouque, H M Omar; Rochford, S E; Sutherland, M F

    2008-11-01

    Tako-tsubo-like cardiomyopathy is characterized by acute chest pain, electrocardiographic changes and increased cardiac enzymes in the absence of obstructive coronary vessel disease. We describe the development of tako-tsubo-like cardiomyopathy in an elderly woman after the use of an EpiPen for generalized urticaria and angioedema. As adrenaline may participate in the pathogenesis of this condition, the need for careful patient selection and education in the use of adrenaline self-injectors remains imperative.

  7. The EpiPen and the ischaemic finger.

    Science.gov (United States)

    Singh, Talvinder; Randhawa, Susheelwant; Khanna, Rakesh

    2007-08-01

    We present a case of a 24-year-old with a history of accidental injection of adrenaline from an EpiPen into the proximal aspect of her left index finger. Various methods were advocated to treat digital ischaemia but were of no benefit. Topical infiltration of phentolamine in 1 ml of lignocaine 2% was given at the puncture site with immediate results of resolution of digital ischaemia.

  8. NCI Start-Up 2.0: An Evaluation Option License Program | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    NCI's Start-Up Evaluation Option License minimizes barriers to entry faced by start-up companies that seek to license NIH technologies. The license encourages and supports the commercial development of early-stage technologies developed in the NIH Intramural Research Program. While the NIH has been quite flexible in structuring licenses for the benefit of start-up companies, one of the goals of the NIH Start-up License program is to further reduce the time and capital to negotiate and finalize an exclusive license agreement. | [google6f4cd5334ac394ab.html

  9. 76 FR 22714 - Proposed Collection; Comment Request; Health Information National Trends Survey 4 (HINTS 4) (NCI)

    Science.gov (United States)

    2011-04-22

    ... understand vital cancer prevention messages. More importantly, this NCI survey will couple knowledge-related... National Trends Survey 4 (HINTS 4) (NCI) SUMMARY: In compliance with the requirement of Section 3506(c)(2... publish periodic summaries of proposed projects to be submitted to the Office of Management and Budget...

  10. Perception of 1 st year medical students towards career choices and specialty of psychiatry

    Directory of Open Access Journals (Sweden)

    Suneet Kumar Upadhyaya

    2015-01-01

    Full Text Available Background: Shortage of psychiatrists is a worldwide phenomenon. If the factors that attract or repel students towards a specialty can be identified, it may be possible to encourage them towards it. Choice of specialty as a career depends on the complex interplay of experiences before, during or after exposure to the specialty. Objectives: The aim was to understand perceptions of 1 st year medical students regarding career choices and the specialty of psychiatry through a cross-sectional questionnaire-based study. Materials and Methods: Perceptions of 137 1 st year medical students from the Government Medical College were recorded using a semi-structured questionnaire. Students provided their opinions about future career choices; perspective of these specialties in terms of financial reward, reputation, work-life balance, challenging aspect, ability to help patients effectively and emotional stability; their preferences in life and interaction with psychiatrist and its impact. Statistical Analysis Used: One-way analysis of variance (ANOVA with post-hoc analysis by Tukey-Kramer test. Results: Surgery was a high priority for 69 (50% while psychiatry was a high priority only for 11 (8%. Surgery was highest for financial reward and reputation, but lowest for work-life balance. Psychiatry had higher emotional stability, however, its the reputation was lower than surgery, medicine, obstetrics and gynaecology and paediatrics. Students preferred reputation (41% over social service opportunities (43%, work-life balance (16%, and high-income (11%. Interaction with psychiatrist increased inclination for psychiatry in 69% (9/13 students. Conclusions: Psychiatry is not a preferred specialty among 1 st year medical students due to its poor reputation.

  11. 1st ESMO Consensus Conference in lung cancer; Lugano 2010: small-cell lung cancer

    DEFF Research Database (Denmark)

    Stahel, R; Thatcher, N; Früh, M;

    2011-01-01

    , the expert panel prepared clinically relevant questions concerning five areas as follows: early and locally advanced non-small-cell lung cancer (NSCLC), first-line metastatic NSCLC, second-/third-line NSCLC, NSCLC pathology and molecular testing, and small-cell lung cancer (SCLC) to be addressed through......The 1st ESMO Consensus Conference on lung cancer was held in Lugano, Switzerland on 21st and 22nd May 2010 with the participation of a multidisciplinary panel of leading professionals in pathology and molecular diagnostics and medical, surgical and radiation oncology. Before the conference...

  12. 1st International Conference on Business Management - “New Challenges in Business Research”

    OpenAIRE

    Calafat Marzal, Maria Consuelo; Martí Selva, María Luisa

    2015-01-01

    We are glad to announce the 1st International Conference on Business Management “New Challenges in Business Research” that will be held in the Faculty of Business Management and Administration of the Universitat Politècnica de València (Valencia, Spain) on 2nd – 3rd of July, 2015. The aim of the conference is to give researchers the opportunity to get together and present unpublished and relevant research studies about different topics on business management and economics. We belie...

  13. 1st International Conference on Computer Science, Applied Mathematics and Applications (ICCSAMA 2013)

    CERN Document Server

    Do, Tien; Thi, Hoai; Advanced Computational Methods for Knowledge Engineering

    2013-01-01

    The book consists of 29 extended chapters which have been selected and invited from the submissions to the 1st International Conference on Computer Science, Applied Mathematics and Applications (ICCSAMA 2013) held on 9-10 May, 2013 in Warsaw, Poland. The book is organized into five parts, which are: Advanced Optimization Methods and Their Applications, Queueing Theory and Applications, Computational Methods for Knowledge Engineering, Knowledge Engineering with Cloud and Grid Computing, and Logic Based Methods for Decision Making and Data Mining, respectively. All chapters in the book discuss theoretical and practical issues connected with computational methods and optimization methods for knowledge engineering.

  14. Energy method for Stability of 1st Order CE with Variable Coefficients

    Institute of Scientific and Technical Information of China (English)

    LIU Ming

    2011-01-01

    It is well known that the Convection--diffusion e- quations arise in the fields of fluid mechanics and has been con- sidered extensively. The solving for these initial boundary value problems includes upwind difference scheme, Las- Friedrichs and Lax-- Wendroff difference schemes etc.. Methods such as Matrix method, the Hirt Heuristic Method and Fourier Method can be used to research the stability of the difference schemes. In the paper, using the 1st order convection equation(CE) with var- iable- coefficients as an example, the author gets the corre- sponding Lax--Wendroff difference scheme first, then Energy Method has been used to analyze the stability of the scheme.

  15. EFFECT OF 1,2-EPOXY-3[3-3[3,4-DIMETOXYI-PHENIL]-4H-1-BENZOPIRAN-4-ON] PROPANE (EPI ON SIRTUIN-1 AND NUCLEAR FACTOR-κB EXPRESSION OF MAMMARY TUMORS INDUCED IN SPRAGUE DAWLEY RATS BY DMBA

    Directory of Open Access Journals (Sweden)

    Ayyub Harly Nurung

    2016-12-01

    Full Text Available ABSTRACT The main factors contribute to breast cancer development is the combination of exogenous and endogenous factors. Endogenous factors include both SIRT1 and NF-kB. Exogenous factor used in this research is 7.12 dimethylbenz(aanthracene (DMBA. 1,2-epoxy-3[3- 3[3,4-dimetoxy-phenil]-4h-1-benzophiran-4-on] propane (EPI is a derivative of isoflavone generate from clove leaf oil. To examine the effect of EPI on SIRT1 and NF-kB expression in DMBA-induced Sprague Dawley (SD rats, and the correlation between SIRT1 and NFkB expressions. Tissue generated form 35 Sprague Dawley female rats aged 2 weeks old were used in this study. Those rats were divided into 7 groups (5 rats/group, namely normal control group; corn oil group; DMBA group; EPI treated groups with 1 mg/kgBW (EPI I, 2 mg/kgBW (EPI II, and 4 mg/kgBW (EPI III, respectively; and doxorubicin group. EPI and doxorubicin were administered from 1st until 15th week, while DMBA were administered from 3rd until 9th week. The paraffin block was prepared from all breast organ of the rats that terminated at the end of week 15th. Examination of SIRT1 and NF-kB expression was performed using light microscope at 400x magnifications, after immunohistochemistry (IHC staining. Expression level of SIRT1 and NF-kB were analyzed using IHC-profiler plug-in in ImageJ software. SIRT1 and NF-kB expression in EPI treated groups were not significantly different with the one in Doxorubicin group, but lower than DMBA group (p=0.000. There was a positive correlation between SIRT1 and NF-kB expression (p=0.001; r=0.773 in EPI-treated group. EPI was able to prevent an increasing of SIRT1 and NF-kB expression in SD model breast cancer that induced with DMBA. There is a positive correlation between SIRT1 and NF-kB expression in EPI-treated SD rats that were induced by DMBA

  16. Softball Games Bring NCI and Leidos Biomed Employees Together | Poster

    Science.gov (United States)

    NCI and Leidos Biomed employees took to the fields at Nallin Pond for the third annual slow-pitch softball games on August 26. The series attracted 54 employees who were divided into four teams, Red, Blue, Gray, and White, and they were cheered on by about 40 enthusiastic spectators. In the first set of games, the Gray team defeated the Blue team, 15–8, and the White team pulled out a win against the Red team, 17–15. After a brief rest, the two winning teams and the two losing teams faced each other in a second set of games. On Field 1, the “winners” match-up of the Gray and White teams was a nail biter, with a close score throughout the game. Daylight was a factor, however, and the team captains decided to call the game for safety reasons. With a lead of 15 to 13, the Gray team was declared the overall winner.

  17. Softball Games Bring NCI and Leidos Biomed Employees Together | Poster

    Science.gov (United States)

    NCI and Leidos Biomed employees took to the fields at Nallin Pond for the third annual slow-pitch softball games on August 26. The series attracted 54 employees who were divided into four teams, Red, Blue, Gray, and White, and they were cheered on by about 40 enthusiastic spectators. In the first set of games, the Gray team defeated the Blue team, 15–8, and the White team pulled out a win against the Red team, 17–15. After a brief rest, the two winning teams and the two losing teams faced each other in a second set of games. On Field 1, the “winners” match-up of the Gray and White teams was a nail biter, with a close score throughout the game. Daylight was a factor, however, and the team captains decided to call the game for safety reasons. With a lead of 15 to 13, the Gray team was declared the overall winner.

  18. Persistent Identifier Practice for Big Data Management at NCI

    Directory of Open Access Journals (Sweden)

    Jingbo Wang

    2017-04-01

    Full Text Available The National Computational Infrastructure (NCI manages over 10 PB research data, which is co-located with the high performance computer (Raijin and an HPC class 3000 core OpenStack cloud system (Tenjin. In support of this integrated High Performance Computing/High Performance Data (HPC/HPD infrastructure, NCI’s data management practices includes building catalogues, DOI minting, data curation, data publishing, and data delivery through a variety of data services. The metadata catalogues, DOIs, THREDDS, and Vocabularies, all use different Uniform Resource Locator (URL styles. A Persistent IDentifier (PID service provides an important utility to manage URLs in a consistent, controlled and monitored manner to support the robustness of our national ‘Big Data’ infrastructure. In this paper we demonstrate NCI’s approach of utilising the NCI’s 'PID Service 'to consistently manage its persistent identifiers with various applications.

  19. Developing a Personal-Learning-Portfolio (PLP) for 1st year students at Department of Psychology

    DEFF Research Database (Denmark)

    Johnsen, Anna Thit; Beck Hansen, Nina; Andersen, Mette Elmose

    Abstract title: Developing a Personal-Learning-Portfolio (PLP) for 1st year students at Department of Psychology Learning outcome of activity: B01 is the first module of the education in Psychology at University of Southern Denmark (SDU). The aim of B01 is to give the students a ‘map’ or a ‘schem......Abstract title: Developing a Personal-Learning-Portfolio (PLP) for 1st year students at Department of Psychology Learning outcome of activity: B01 is the first module of the education in Psychology at University of Southern Denmark (SDU). The aim of B01 is to give the students a ‘map......’ or a ‘schemata’ of psychology that they will later expand and modify throughout their education. This is done by introducing the students to the history of psychology, its theory of science and its different fields. However, feedback from our students told us that the risk of this objective is that the class...... be an inspiration to others who wish to develop and implements PLPs. Second, we will show the format of our particular Personal-Learning-Portfolio together with reflections on why it was developed in such a way. This includes the students’ opinions about the PLP and the results of the cognitive interviews....

  20. Syntheses of (+)-alismoxide and (+)-4-epi-alismoxide.

    Science.gov (United States)

    Blay, Gonzalo; García, Begoña; Molina, Eva; Pedro, José R

    2006-09-29

    The first total syntheses of (+)-alismoxide and (+)-4-epi-alismoxide are reported. Formal chemo-, regio-, and stereoselective addition of water to 10alpha-acetoxy-1alphaH,5betaH-guaia-3,6-diene afforded the target compounds after reduction. The absolute stereochemistry of (+)-alismoxide has been established. The low [alpha](D) +8.6 value indicates that significant amounts of alismoxide result from biosynthetic processes. Furthermore, the structure of the natural guaienediol isolated from Silphium perfoliatum has been corrected to (-)-alismoxide.

  1. Total Synthesis of Putative 11-epi-Lyngbouilloside Aglycon

    Science.gov (United States)

    Kolleth, Amandine; Gebauer, Julian; ElMarrouni, Abdelatif; Lebeuf, Raphael; Prévost, Céline; Brohan, Eric; Arseniyadis, Stellios; Cossy, Janine

    2016-01-01

    We report here the total synthesis of 11-epi-lyngbouilloside aglycon. Our strategy features a Boeckman-type esterification followed by a RCM to form the 14-membered ring macrolactone and a late-stage side chain introduction via a Wittig olefination. Overall, the final product was obtained in 20 steps and 2% overall yield starting from commercially available 3-methyl-but-3-enol. Most importantly, the strategy employed is versatile enough to eventually allow us to complete the synthesis of the natural product and irrevocably confirm its structure. PMID:27556024

  2. File list: ALL.PSC.50.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  3. File list: ALL.PSC.10.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.10.AllAg.EpiSC mm9 All antigens Pluripotent stem cell EpiSC SRX590288,SRX53...RX590290,SRX1074917,SRX1074916,SRX590285,SRX590286,SRX535242,SRX1074908,SRX1074905,SRX535238,SRX535237 http://dbarchive.biosc...iencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.10.AllAg.EpiSC.bed ...

  4. File list: ALL.PSC.05.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.05.AllAg.EpiSC mm9 All antigens Pluripotent stem cell EpiSC SRX590288,SRX53...RX590290,SRX590289,SRX590285,SRX1074916,SRX1074917,SRX590286,SRX535242,SRX1074908,SRX1074905,SRX535237 http://dbarchive.biosc...iencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.05.AllAg.EpiSC.bed ...

  5. File list: ALL.PSC.20.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.20.AllAg.EpiSC mm9 All antigens Pluripotent stem cell EpiSC SRX535239,SRX66...RX590289,SRX590285,SRX590290,SRX590286,SRX1074909,SRX1074908,SRX1074905,SRX1074906,SRX535237,SRX535241 http://dbarchive.biosc...iencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.20.AllAg.EpiSC.bed ...

  6. 13-Epi-9-deacetoxyxenicin, a Cytotoxic Diterpene from the Soft Coral Asterospicularia laurae (Alcyonacea

    Directory of Open Access Journals (Sweden)

    Bruce F. Bowden

    2003-11-01

    Full Text Available Abstract: An investigation of the soft coral Asterospicularia laurae collected on the Great Barrier Reef, Australia, afforded the cytotoxic diterpene 13-epi-9-deacetoxyxenicin (1 in addition to the known metabolites 13-epi-9-deacetylxenicin (2 and gorgosterol. 13-Epi-9-deacetoxyxenicin readily underwent an autoxidation reaction in solution to afford a single product, the hydroperoxide 3. Structures, stereochemistry, and NMR assignments were established by high resolution NMR spectroscopy and by comparison with published data for known compounds.

  7. EDITORIAL: The 1st International Conference on Nanomanufacturing (NanoMan2008) The 1st International Conference on Nanomanufacturing (NanoMan2008)

    Science.gov (United States)

    Luo, Jack Jiqui; Fang, Fengzhou

    2009-05-01

    Nanomanufacturing is an emerging technology in the field of synthesis of nanomaterials, manufacture of nanodevices, nanosystems and the relevant characterization technologies, and will greatly impact our society and environment: speeding up scientific discovery, technological development, improving healthcare and living standards and slowing down the exhaustion of energy resources, to name but few. The 1st International Conference on Nanomanufacturing (NanoMan2008) was held on the 13-16 July 2008 in Singapore in conjunction with ThinFilm2008 (The 4th International Conference on Technological Advances of Thin Films & Surface Coatings). Approximately 140 delegates from all over the world have participated in the conference and presented their latest discoveries and technological developments. The main focuses of the conference were modern nanomanufacturing by laser machining, focused ion beam fabrication, nano/micro-molding/imprinting, nanomaterial synthesis and characterization, nanometrology and nano/microsystems fabrication and characterization. There was also great interest in applications of nanomanufacturing technologies in traditional areas such as free form machining, polishing and grinding with nano-scale precision and the smoothness of surfaces of objects, and applications in space exploration, military and medicine. This special issue is devoted to NanoMan2008 with a collection of 9 invited talks presented at the conference, covering all the topics of nanomanufacturing technology and development. These papers have been upgraded by the authors with new results and discoveries since the preparation of the conference manuscripts, hence presenting the latest developments. We would like to take this opportunity to thank all the delegates who attended the conference and made the conference successful, and to the authors who contributed papers to this special issue. Thanks also go to the conference committee for their efforts and devotion to the conference. We

  8. A comparison of Epi-Lock and saline dressings in the treatment of pressure ulcers.

    Science.gov (United States)

    Kraft, M R; Lawson, L; Pohlmann, B; Reid-Lokos, C; Barder, L

    1993-11-01

    The use of Epi-Lock dressings was compared to moist saline dressings as a treatment for Stage II and III pressure ulcers in 38 patients. Demographic and clinical data were collected at the onset of the investigation. At the time of enrollment and during weeks six, 12 and 24, pressure ulcers were inspected and measured, and laboratory data were collected. More healing occurred with Epi-Lock dressing than with moist saline dressing for Stage II and III pressure ulcers. Although individual Epi-Lock dressings were more expensive than saline dressings, they required less dressing changes. Therefore considering cost of nursing time, Epi-Lock dressings are more cost effective.

  9. Epi Info 2002的基本操作简介

    Institute of Scientific and Technical Information of China (English)

    梁青山

    2004-01-01

    Epi Info 2002是美国疾病预防控制中心(CDC)和世界卫生组织(WHO)继Epi Info 2000版之后于2002年11月推出的最新Epi Info版本。该版本功能更为完善,设计更为合理,界面更为美观。笔者兹就Epi Info 2002的基本操作方法和步骤简要介绍如下。

  10. 1st International Symposium and 10th Balkan Conference on Operational Research

    CERN Document Server

    Sifaleras, Angelo; Georgiadis, Christos; Papathanasiou, Jason; Stiakakis, Emmanuil

    2013-01-01

    Over the past two decades, the Balkan Conference on Operational Research (BALCOR) has facilitated the exchange of scientific and technical information on the subject of Operations Research and related fields such as Mathematical Programming, Game Theory, Multiple Criteria Decision Analysis, Information Systems, Data Mining, and more, in order to promote international scientific cooperation.  The contributed papers contained in this volume consist of 25 selected research papers based on results presented at the 10th Balkan Conference & 1st International Symposium on Operational Research in Thessalonike, Greece. Subjects include, but do not restrict to, the development of theory and mathematical models for Operations Research, theory and applications of Combinatorial Optimization, Supply Chain Optimization, and Military Operations Research.  These carefully selected papers present important recent developments and modern applications, and will serve as excellent reference for students, researchers, and pr...

  11. Summary of the 1st International Workshop on Environmental, Safety and Economic Aspects of Fusion Power

    Science.gov (United States)

    Wu, Y.; Stevens, E.; Kim, K.; Maisonnier, D.; Kalashnikov, A.; Tobita, K.; Jackson, D.; Alejaldre, C.; Perrault, D.; Panayotov, D.; Merrill, B.; Grisolia, C.; Zucchetti, M.; Pinna, T.; van Houtte, D.; Konishi, S.; Kolbasov, B.

    2016-12-01

    The 1st International workshop on Environmental, Safety and Economic Aspects of Fusion Power (ESEFP) was held on 13 September 2015 at Jeju Island, South Korea. The workshop was initiated by the International Energy Agency Implementing Agreement on a Co-operative Program on ESEFP. The workshop was well attended with about forty participants representing twelve institutions in ten countries. The presentations covered safety issues and environmental impacts, availability improvement and risk control and socio-economic aspects of fusion power. Safety and licensing gaps between DEMO and ITER were discussed in depth with the consensus output presented as a plenary presentation at the 12th International Symposium on Fusion Nuclear Technology (ISFNT-12). The next workshop is planned to be held in conjunction with the ISFNT-13 in 2017.

  12. Idaho National Laboratory Quarterly Occurrence Analysis - 1st Quarter FY 2016

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Lisbeth Ann [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 74 reportable events (16 from the 1st Qtr FY-16 and 58 from the prior three reporting quarters), as well as 35 other issue reports (including events found to be not reportable and Significant Category A and B conditions) identified at INL during the past 12 months (15 from this quarter and 20 from the prior three quarters).

  13. 1st European-Middle Asian Conference on Computer Modelling 2015

    CERN Document Server

    Kolosov, Dmitrii; Snášel, Václav; Karakeyev, Taalaybek; Abraham, Ajith

    2016-01-01

    This volume of Advances in Intelligent Systems and Computing contains papers presented at the 1st European-Middle Asian Conference on Computer Modelling, EMACOM 2015. This international conference was conceived as a brand new scientific and social event of mutual collaboration between the VSB - Technical University of Ostrava (Ostrava, Czech Republic) and the Kyrgyz National University named after J. Balasagyn (Bishkek, Kyrgyz Republic). The aim of EMACOM 2015 was to present the latest development in the field of computer-aided modelling as an essential aspect of research and development of innovative systems and their applications. The conference showed that together with simulations, various modeling techniques, enabled and encouraged by the rapid development of high-performance computing platforms, are crucial for cost-efficient design, verification, and prototyping of solutions in many diverse industrial fields spanning the whole range from manufacturing, mining, machinery, and automotive industries to in...

  14. 1st International Conference on Computational Advancement in Communication Circuits and Systems

    CERN Document Server

    Dalapati, Goutam; Banerjee, P; Mallick, Amiya; Mukherjee, Moumita

    2015-01-01

    This book comprises the proceedings of 1st International Conference on Computational Advancement in Communication Circuits and Systems (ICCACCS 2014) organized by Narula Institute of Technology under the patronage of JIS group, affiliated to West Bengal University of Technology. The conference was supported by Technical Education Quality Improvement Program (TEQIP), New Delhi, India and had technical collaboration with IEEE Kolkata Section, along with publication partner by Springer. The book contains 62 refereed papers that aim to highlight new theoretical and experimental findings in the field of Electronics and communication engineering including interdisciplinary fields like Advanced Computing, Pattern Recognition and Analysis, Signal and Image Processing. The proceedings cover the principles, techniques and applications in microwave & devices, communication & networking, signal & image processing, and computations & mathematics & control. The proceedings reflect the conference’s emp...

  15. The 1st Fermi LAT SNR Catalog: the Impact of Interstellar Emission Modeling

    CERN Document Server

    Brandt, T J; de Palma, F; Johannesson, G; Tibaldo, L

    2013-01-01

    Galactic interstellar emission contributes substantially to Fermi LAT observations in the Galactic plane, the location of the majority of supernova remnants (SNRs). To explore some systematic effects on SNRs' properties caused by interstellar emission modeling, we have developed a method comparing the official LAT interstellar emission model results to eight alternative models. We created the eight alternative Galactic interstellar models by varying a few input parameters to GALPROP, namely the height of the cosmic ray propagation halo, cosmic ray source distribution in the Galaxy, and atomic hydrogen spin temperature. We have analyzed eight representative SNRs chosen to encompass a range of Galactic locations, extensions, and spectral properties using the eight different interstellar emission models. We will present the results and method in detail and discuss the implications for studies such as the 1st Fermi LAT SNR Catalog.

  16. The new Facilities Management contract at CERN from 1st July 2002

    CERN Document Server

    Mauro Nonis

    2002-01-01

    Within the ST Division, all the Facilities Management activities have been under the ST/TFM group responsibility until the 30th June 2002, who has performed them using around 20 industrial support contracts. Starting from the 1st July 2002 a new unit, ST/FM, will take over these activities that will be unified into one single contract that has been adjudicated to the company Facilities Management Network SA. This contract will be in charge of the maintenance and minor works on tertiary installations (i.e. all structures and installations that have no direct relation to the running of the accelerators) for the following trades: - Technical: heating, ventilation, air conditioning, plumbing, electricity, civil engineering (painting, roofing, glazing, blinds, fencing, masonry etc.), passenger and goods lifts, automatic and powered doors, kitchen equipment, roads, signs, keys and locks, office furniture, - Services: waste collection, security, green areas, cleaning and sanitary supplies, disinfection, rodent cont...

  17. THE NEW FACILITIES MANAGEMENT CONTRACT AT CERN FROM 1st JULY 2002

    CERN Multimedia

    Mauro Nonis

    2002-01-01

    Within the ST Division, all the Facilities Management activities have been under the ST/TFM group responsibility until the 30th June 2002, who has performed them using around 20 industrial support contracts. Starting from the 1st July 2002 a new unit, ST/FM, will take over these activities that will be unified into one single contract that has been adjudicated to the company Facilities Management Network SA. This contract will be in charge of the maintenance and minor works on tertiary installations (i.e. all structures and installations that have no direct relation to the running of the accelerators) for the following trades: Technical: heating, ventilation, air conditioning, plumbing, electricity, civil engineering (painting, roofing, glazing, blinds, fencing, masonry etc.), passenger and goods lifts, automatic and powered doors, kitchen equipment, roads, signs, keys and locks, office furniture, Services: waste collection, security, green areas, cleaning and sanitary supplies, disinfection, rodent contro...

  18. Statistical Ring Opening Metathesis Copolymerization of Norbornene and Cyclopentene by Grubbs’ 1st-Generation Catalyst

    Directory of Open Access Journals (Sweden)

    Christiana Nikovia

    2015-08-01

    Full Text Available Statistical copolymers of norbornene (NBE with cyclopentene (CP were prepared by ring-opening metathesis polymerization, employing the 1st-generation Grubbs’ catalyst, in the presence or absence of triphenylphosphine, PPh3. The reactivity ratios were estimated using the Finemann-Ross, inverted Finemann-Ross, and Kelen-Tüdos graphical methods, along with the computer program COPOINT, which evaluates the parameters of binary copolymerizations from comonomer/copolymer composition data by integrating a given copolymerization equation in its differential form. Structural parameters of the copolymers were obtained by calculating the dyad sequence fractions and the mean sequence length, which were derived using the monomer reactivity ratios. The kinetics of thermal decomposition of the copolymers along with the respective homopolymers was studied by thermogravimetric analysis within the framework of the Ozawa-Flynn-Wall and Kissinger methodologies. Finally, the effect of triphenylphosphine on the kinetics of copolymerization, the reactivity ratios, and the kinetics of thermal decomposition were examined.

  19. Cancer incidence among 1st generation migrants compared to native Danes--a retrospective cohort study

    DEFF Research Database (Denmark)

    Nørredam, Marie Louise; Krasnik, A; Pipper, C

    2007-01-01

    had a significantly lower incidence. All migrants had a significantly lower incidence of breast and colorectal cancer but male migrants from East Europe had a significantly higher incidence of lung cancer. CONCLUSIONS: The overall cancer incidence among migrants was lower compared to native Danes......STUDY AIMS: To investigate the incidence of cancer among 1st generation migrants compared to native Danes, including time trends in the risk of cancer among migrants. METHODS: A retrospective cohort study design. Migrants were matched 1:4 on age and sex with a Danish born reference population....... The cohort was linked to the Danish Cancer Register and cancer cases among migrants (n=537) and native Danes (n=2829) were identified. RESULTS: The overall cancer incidence did not differ significantly between migrants from East Europe and native Danes; whereas migrants from the Middle East and North Africa...

  20. Challenges of changing a PBL-related curriculum for 1st year students

    DEFF Research Database (Denmark)

    Bruun-Pedersen, Jon Ram; Kofoed, Lise B.

    2011-01-01

    This paper discusses a transition related to a reformed study plan in the specific case of the Aalborg University education of Medialogy; a Bachelor and Master program with an average of 80 students starting 1st semester. Among other things, the change meant a new structure for preparation...... plan. The method used is based on an analysis of the students’ Process Analyses, a learning portfolio, where a project group of up to 7 students analyse and reflect on the CLP-related process of realizing their semester project. The theoretical background of the comparative analysis is based......, teaching and evaluation for the course: Cooperation, Learning and Project Management (CLP). This paper will discuss the implications, based on the students’understanding of the subject matter, the degree of practical use of the course curriculum in their project work, and compare it to the former study...

  1. Environmental engineering education - summary report of the 1st European Seminar

    DEFF Research Database (Denmark)

    Alha, K; Holliger, C.; Larsen, Bo Skjold;

    2000-01-01

    This paper summarizes the discussions of the 1st European Seminar on Environmental Engineering Education (E3), which was held at EAWAG, Zurich, Switzerland in August 1999. Although the emerging discipline of environmental engineering, which was once viewed as being a sub-set of civil or chemical...... engineering, has established a status in its own right, a definition of environmental engineering is still not agreed among European engineering educators. This report discusses the variation between European countries and the way in which higher education institutions in these countries address...... the educational needs of environmental engineers. A review of the acceptance of this new discipline by employers and the status of environmental engineering as a profession throughout Europe is presented. The question of how to achieve greater compatibility and comparability of the systems of environmental...

  2. Virtual Visit to the ATLAS Control Room by 1st and 3rd Lyceums in Chios

    CERN Multimedia

    2013-01-01

    High school students from the 1st and 3rd Lyceums of Chios, Greece, will be visiting the control room of ATLAS to discuss the latest results on the Higgs search, LHC’s first long shutdown and what the future holds for the ATLAS experiment. This visit takes place in the context of a Masterclass where students will learn how to analyse real events from the LHC with the use of the HYPATIA online applet based on educational scenarios from the Discover the COSMOS portal. This full-day activity is organized by the University of Athens, the University of the Aegean, Ellinogermaniki Agogi and the Chios Physical Society in the framework of the Open Discovery Space EU project.

  3. Proceedings of the 1st International Workshop on High-Speed and Intercity Railways

    CERN Document Server

    Ye, Xiao-Wei

    2012-01-01

    This book contains the papers included in the proceedings of the 1st International Workshop on High-speed and Intercity Railways (IWHIR 2011) held in Shenzhen and Hong Kong, China from July 19 to July 22, 2011, which is organized by The Hong Kong Polytechnic University, in collaboration with Southwest Jiaotong University, Beijing Jiaotong University, Dalian Jiaotong University, China Engineering Consultants, Inc., Zhejiang University, and Tsinghua University. Continuing the great initiatives and momentums of the rapid development in high-speed and intercity railways worldwide in recent years, IWHIR 2011 aims at providing a platform for academic scholars and practicing engineers to share knowledge and experience, to promote collaboration, and to strengthen R&D activities related to railway engineering. Engineers, scientists, professors, and students from universities, research institutes, and related industrial companies have been cordially invited to participate in the workshop. These papers have covered ...

  4. Idaho National Laboratory Quarterly Occurrence Analysis for the 1st Quarter FY2017

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Lisbeth Ann [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-01-01

    This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 82 reportable events (13 from the 1st quarter (Qtr) of fiscal year (FY) 2017 and 68 from the prior three reporting quarters), as well as 31 other issue reports (including events found to be not reportable and Significant Category A and B conditions) identified at INL during the past 12 months (seven from this quarter and 24 from the prior three quarters).

  5. Proceedings of the 1st International Workshop on High-Speed and Intercity Railways

    CERN Document Server

    Ye, Xiao-Wei

    2012-01-01

    This book contains the papers included in the proceedings of the 1st International Workshop on High-speed and Intercity Railways (IWHIR 2011) held in Shenzhen and Hong Kong, China from July 19 to July 22, 2011, which is organized by The Hong Kong Polytechnic University, in collaboration with Southwest Jiaotong University, Beijing Jiaotong University, Dalian Jiaotong University, China Engineering Consultants, Inc., Zhejiang University, and Tsinghua University. Continuing the great initiatives and momentums of the rapid development in high-speed and intercity railways worldwide in recent years, IWHIR 2011 aims at providing a platform for academic scholars and practicing engineers to share knowledge and experience, to promote collaboration, and to strengthen R&D activities related to railway engineering. Engineers, scientists, professors, and students from universities, research institutes, and related industrial companies have been cordially invited to participate in the workshop. These papers have covered ...

  6. NCI Requests Targets for Monoclonal Antibody Production and Characterization - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    In an effort to provide well-characterized monoclonal antibodies to the scientific community, NCI's Antibody Characterization Program requests cancer-related protein targets for affinity production and distribution.

  7. Identification of a new restriction endonuclease R.NciII, from Neisseria cinerea.

    Science.gov (United States)

    Piekarowicz, A

    1994-01-01

    Site-specific restriction endonuclease R. Nci II has been purified from Neisseria cinerea strain 32615. The enzyme recognizes the sequence 5' GATC 3' and its activity is inhibited by the presence of methylated adenine residue within the recognition sequence.

  8. NCI and the Chinese Academy of Medical Sciences Sign Statement of Intent

    Science.gov (United States)

    Today the National Cancer Institute (NCI) and the Cancer Institute/Hospital of the Chinese Academy of Medical Sciences (CICAMS) signed a statement of intent to share an interest in fostering collaborative biomedical research in oncology and a common goal

  9. National Medal of Technology Awarded to NCI Drs. Lowy and Schiller

    Science.gov (United States)

    President Obama announced that two NCI scientists would be recipients of the National Medal of Technology and Innovation -- the nation's highest honor for technological achievement. The honorees, John Schiller, Ph.D., Laboratory of Cellular Oncology (LCO)

  10. Gardasil® and Cervarix® | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    Vaccine for human papilloma virus (HPV) to protect from cancers Key elements of the technology for Gardasil® and Cervarix originated from the HPV research of the laboratory of Drs. Douglas Lowy and John Schiller of the NCI.

  11. Ratio Based Biomarkers for the Prediction of Cancer Survival | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The NCI seeks licensees or co-development partners for this technology, which describes compositions, methods and kits for identifying, characterizing biomolecules expressed in a sample that are associated with the presence, the development, or progression of cancer.

  12. [Epi-Bowman Keratectomy: Clinical Evaluation of a New Method of Surface Ablation].

    Science.gov (United States)

    Taneri, S; Kießler, S; Rost, A; Schultz, T; Elling, M; Dick, B

    2017-02-10

    Purpose A new device for epithelial abrasion before excimer laser surface ablation or corneal cross-linking (CXL) has recently been introduced (Epi-Clear™, Orca Surgical, Kiryat-Shmona, Israel). We have reviewed the literature on the clinical results, potential benefits and drawbacks of this instrument, compared to other methods of epithelial removal. Method Literature search for "Epi-Bowman Keratectomy", "Epi-clear", and "Epikeratome" yielded 1 peer-review publication, 1 non-peer-review publication, 18 posters and presentations at international conferences (European Society of Cataract and Refractive Surgeons [ESCRS] and American Society of Cataract and Refractive Surgery [ASCRS]) on the use of the Epi-Clear™ device before surface ablation, 2 posters on the use of Epi-Clear before corneal crosslinking and 1 presentation on the experimental use of Epi-Clear for removal of a pterygium. Results Comparison of laser ablation after epithelial removal with the Epi-Clear device (Epi-Bowman Keratectomy™, EBK™) to other established methods of surface ablation, i.e. alcohol-assisted PRK or PRK with a metallic scraper, EBK, suggests that the results are generally similar. Pain perception, haze formation, and epithelial healing are reported to be better than with conventional surface ablation methods. Studies evaluating the use of the Epi-Clear device before CXL report that the healing time is significantly reduced and that less pain is perceived. Conclusion The Epi-Clear device seems to be a promising new option for epithelial removal before refractive laser ablation, although a convincing explanation for its potential superiority is still missing. In contrast, when the Epi-Clear device is used before CXL, then the Bowman's layer remains intact; this may provide an adequate explanation for the reported benefits of this application. However, currently available studies are of low level of evidence, so that more prospective randomised trials are needed for a robust

  13. College Graduate with NCI Internship Gains Experience, Carries Chemistry into Medicine | Poster

    Science.gov (United States)

    For Jennifer Marshall, the skills learned through an internship at the National Cancer Institute (NCI) at Frederick have prepared her for the next step of her life—medical school. Marshall, who will be attending the West Virginia University School of Medicine in the fall, spent three summers in NCI at Frederick’s Summer Internship Program expanding her love and passion for science and the medical field.

  14. Estadística descriptiva per a ciències de la salut

    OpenAIRE

    Sanjuan i Nebot, Lluís Francesc

    2016-01-01

    Aquests materials han rebut un incentiu del Servei de Política Lingüística Apunts d'estadística descriptiva per a estudients de l'àrea de les ciències de la salut Apunts d'estadística descriptiva orientats a graus de l'àrea de les ciències de la salut

  15. Estadística descriptiva per a ciències de la salut

    OpenAIRE

    Sanjuan i Nebot, Lluís Francesc

    2016-01-01

    Aquests materials han rebut un incentiu del Servei de Política Lingüística Apunts d'estadística descriptiva per a estudients de l'àrea de les ciències de la salut Apunts d'estadística descriptiva orientats a graus de l'àrea de les ciències de la salut

  16. Data mining the NCI60 to predict generalized cytotoxicity.

    Science.gov (United States)

    Lee, Adam C; Shedden, Kerby; Rosania, Gustavo R; Crippen, Gordon M

    2008-07-01

    Elimination of cytotoxic compounds in the early and later stages of drug discovery can help reduce the costs of research and development. Through the application of principal components analysis (PCA), we were able to data mine and prove that approximately 89% of the total log GI 50 variance is due to the nonspecific cytotoxic nature of substances. Furthermore, PCA led to the identification of groups of structurally unrelated substances showing very specific toxicity profiles, such as a set of 45 substances toxic only to the Leukemia_SR cancer cell line. In an effort to predict nonspecific cytotoxicity on the basis of the mean log GI 50, we created a decision tree using MACCS keys that can correctly classify over 83% of the substances as cytotoxic/noncytotoxic in silico, on the basis of the cutoff of mean log GI 50 = -5.0. Finally, we have established a linear model using least-squares in which nine of the 59 available NCI60 cancer cell lines can be used to predict the mean log GI 50. The model has R (2) = 0.99 and a root-mean-square deviation between the observed and calculated mean log GI 50 (RMSE) = 0.09. Our predictive models can be applied to flag generally cytotoxic molecules in virtual and real chemical libraries, thus saving time and effort.

  17. Characterization of a silent sesquiterpenoid biosynthetic pathway in Streptomyces avermitilis controlling epi-isozizaene albaflavenone biosynthesis and isolation of a new oxidized epi-isozizaene metabolite.

    Science.gov (United States)

    Takamatsu, Satoshi; Lin, Xin; Nara, Ayako; Komatsu, Mamoru; Cane, David E; Ikeda, Haruo

    2011-03-01

    The genome-sequenced, Gram-positive bacterium Streptomyces avermitilis harbours an orthologue (SAV_3032) of the previously identified epi-isozizaene synthase (SCO5222) in Streptomyces coelicolor A3(2). The sav3032 is translationally coupled with the downstream sav3031 gene encoding the cytochrome P450 CYP170A2 analogous to SCO5223 (CYP170A1) of S. coelicolor A3(2), which exhibits a similar translation coupling. Streptomyces avermitilis did not produce epi-isozizaene or any of its oxidized derivatives, albaflavenols and albaflavenone, under in any culture conditions examined. Nonetheless, recombinant SAV_3032 protein expressed in Escherichia coli catalysed the Mg²+-dependent cyclization of farnesyl diphosphate to epi-isozizaene. To effect the production of epi-isozizaene in S. avermitilis, the sav3032 gene was cloned and placed under control of a copy of the native S. avermitilis promoter rpsJp (sav4925). The derived expression construct was introduced by transformation into a large-deletion mutant of S. avermitilis SUKA16 and the resulting transformants accumulated epi-isozizaene. The previously characterized oxidized epi-isozizaene metabolites (4R)- and (4S)-albaflavenols and albaflavenone, as well as a previously undescribed doubly oxidized epi-isozizaene derivative were isolated from cultures of S. avermitilis SUKA16 transformants in which sav3032 was coexpressed with the P450-encoding sav3031. This new metabolite was identified as 4β,5β-epoxy-2-epi-zizaan-6β-ol which is most likely formed by oxidation of (4S)-albaflavenol.

  18. A comparative study of stromal reaction in Epi-on & Epi-off techniques post- C3R in Keratoconus patients with OCT.

    Directory of Open Access Journals (Sweden)

    Dr. Suruchi B. Agarwal

    2014-12-01

    Full Text Available TITLE: A patient study of Stromal Reaction after C3R with OCT and comparing Epi-On & Epi-Off techniques in Keratoconus patients. PURPOSE: To report a study of 20 patients of keratoconus showing the effect on the corneal structure and stromal reaction in post Corneal Collagen Cross Linking (C3R, through the Anterior Segment imaging technique- OCT METHODS: A Study was done from 15.7.2014 to 30.9.2014 of 20 patients having keratoconus, progressive type, where Collagen Cross linking was decided as the method of management (10 each of Epi-on and Epi-off technique. In the Epi-off technique, the epithelium was removed prior to corneal soakage of a dextran-based 0.1% photo sensitizer riboflavin solution for 30 minutes, followed by exposure of ultraviolet-A (typically 365-370 μm light for 30 min with an intensity of 3 mW/cm 2 and 5.4 J/cm 2 of energy. In the Epi-on technique, a special dextran-trometamol EDTA based 0.1% riboflavin solution is used without scrapping the cornea, rest of the method is same. One week after the C3R procedure, the anterior segment OCT was done. RESULTS: In the first few weeks after cross-linking, a faint hyper reflectivity is noted in the anterior stroma, a distinct demarcation between the cross-linked and non-cross-linked areas of the cornea, the depth of demarcation line and the change in the corneal thickness was noted. CONCLUSION: In both the Epi-on and Epi-off technique, the change in the stromal thickness and demarcation line is same. Hence we conclude that both the techniques are equally effective.

  19. 1st or 2nd generation bioethanol-impacts of technology integration & on feed production and land use

    DEFF Research Database (Denmark)

    Bentsen, Niclas Scott; Felby, Claus

    2009-01-01

    on agricultural land on a global scale, but increase the pressure on local/national scale. In contrast to that 2nd generation bioethanol based on wheat straw exhibits a poorer energy balance than 1st generation, but the induced imbalances on feed energy are smaller. Proteins are some of the plant components...... production comparable to gasoline production in terms of energy loss. Utilisation of biomass in the energy sector is inevitably linked to the utilisation of land. This is a key difference between fossil and bio based energy systems. Thus evaluations of bioethanol production based on energy balances alone...... are inadequate. 1st and 2nd generation bioethanol production exhibits major differences when evaluated on characteristics as feed energy and feed protein production and subsequently on land use changes. 1st generation bioethanol production based on wheat grain in Denmark may in fact reduce the pressure...

  20. PREFACE: 1st International Conference on Rheology and Modeling of Materials

    Science.gov (United States)

    Gömze, László A.

    2015-04-01

    Understanding the rheological properties of materials and their rheological behaviors during their manufacturing processes and in their applications in many cases can help to increase the efficiency and competitiveness not only of the finished goods and products but the organizations and societies also. The more scientific supported and prepared organizations develop more competitive products with better thermal, mechanical, physical, chemical and biological properties and the leading companies apply more competitive knowledge, materials, equipment and technology processes. The idea to organize in Hungary the 1st International Conference on Rheology and Modeling of Materials we have received from prospective scientists, physicists, chemists, mathematicians and engineers from Asia, Europe, North and South America including India, Korea, Russia, Turkey, Estonia, France, Italy, United Kingdom, Chile, Mexico and USA. The goals of ic-rmm1 the 1st International Conference on Rheology and Modeling of Materials are the following: • Promote new methods and results of scientific research in the fields of modeling and measurements of rheological properties and behavior of materials under processing and applications. • Change information between the theoretical and applied sciences as well as technical and technological implantations. • Promote the communication between the scientists of different disciplines, nations, countries and continents. The international conference ic-rmm1 provides a platform among the leading international scientists, researchers, PhD students and engineers for discussing recent achievements in measurement, modeling and application of rheology in materials technology and materials science of liquids, melts, solids, crystals and amorphous structures. Among the major fields of interest are the influences of material structures, mechanical stresses temperature and deformation speeds on rheological and physical properties, phase transformation of

  1. PREFACE: 1st European Conference on Gas Micro Flows (GasMems 2012)

    Science.gov (United States)

    Frijns, Arjan; Valougeorgis, Dimitris; Colin, Stéphane; Baldas, Lucien

    2012-05-01

    The aim of the 1st European Conference on Gas Micro Flows is to advance research in Europe and worldwide in the field of gas micro flows as well as to improve global fundamental knowledge and to enable technological applications. Gas flows in microsystems are of great importance and touch almost every industrial field (e.g. fluidic microactuators for active control of aerodynamic flows, vacuum generators for extracting biological samples, mass flow and temperature micro-sensors, pressure gauges, micro heat-exchangers for the cooling of electronic components or for chemical applications, and micro gas analyzers or separators). The main characteristic of gas microflows is their rarefaction, which for device design often requires modelling and simulation both by continuous and molecular approaches. In such flows various non-equilibrium transport phenomena appear, while the role played by the interaction between the gas and the solid device surfaces becomes essential. The proposed models of boundary conditions often need an empirical adjustment strongly dependent on the micro manufacturing technique. The 1st European Conference on Gas Micro Flows is organized under the umbrella of the recently established GASMEMS network (www.gasmems.eu/) consisting of 13 participants and six associate members. The main objectives of the network are to structure research and train researchers in the fields of micro gas dynamics, measurement techniques for gaseous flows in micro experimental setups, microstructure design and micro manufacturing with applications in lab and industry. The conference takes place on June 6-8 2012, at the Skiathos Palace Hotel, on the beautiful island of Skiathos, Greece. The conference has received funding from the European Community's Seventh Framework Programme FP7/2007-2013 under grant agreement ITN GASMEMS no. 215504. It owes its success to many people. We would like to acknowledge the support of all members of the Scientific Committee and of all

  2. [Prevalence and causes of pain after cataract surgery: Comparison of 1st and 2nd eyes].

    Science.gov (United States)

    Gayadine-Harricham, Y; Amzallag, T

    2017-06-01

    In our practice, patients undergoing bilateral cataract surgery complain of more significant pain after the 2nd eye surgery. The goal of this study was to compare postoperative pain between the 1st and 2nd eyes with cataract surgery under topical anesthesia and to identify the causes of this pain. We conducted a prospective observational study between May and September 2015. We included 69 consecutive adults scheduled for bilateral cataract surgery under topical anesthesia within 2 months by the same surgeon. A self-assessment questionnaire of anxiety (the Amsterdam Preoperative Anxiety and Information Scale [APAIS]) was completed before each procedure. Postoperative pain was assessed by the visual analogue scale (VAS) in the recovery room. Among the 69 included patients (mean age: 70±1.3 years), 13 (19%) experienced more pain after the 2nd eye procedure. The median VAS was 0 (EI: 0-1) after the first eye versus 0 (EI: 0-2) after the second eye (P=0.836). The patients with the most pain after the second eye surgery had a median anxiety score of 5 (EI: 4 to 9.5), which was comparable to those without pain (P=0.589). On bivariate analysis, women had more pain after second eye surgery (27%) than men (4%) (P=0.026). However, this association lost its significance when the analysis was adjusted for the level of anxiety (adjusted OR 7.7, 95% CI [0.91; 64.6]). In fact, women were more anxious [median anxiety score of 6 (EI: 4 to 8.5)] before 2nd eye surgery than men [median score: 4 (EI: 4-6); P=0.013]. Pain levels appeared to be very moderate on both sides when measured postoperatively, as opposed to statements often made in the immediate postoperative period. There is a discrepancy with the literature data. However, each study had small sample sizes. We did not find any significant difference in pain between 1st and 2nd eye cataract surgery under topical local anesthesia. While postoperative pain appeared greater among women, we have noted the possible influence of

  3. Cardiac-Specific EPI64C Blunts Pressure Overload-Induced Cardiac Hypertrophy.

    Science.gov (United States)

    Zhu, Xuehai; Fang, Jing; Gong, Jun; Guo, Jun-Hong; Zhao, Guang-Nian; Ji, Yan-Xiao; Liu, Hong-Yun; Wei, Xiang; Li, Hongliang

    2016-05-01

    The calcium-responsive molecule, calcineurin, has been well characterized to play a causal role in pathological cardiac hypertrophy over the past decade. However, the intrinsic negative regulation of calcineurin signaling during the progression of cardiomyocyte hypertrophy remains enigmatic. Herein, we explored the role of EPI64C, a dual inhibitor of both Ras and calcineurin signaling during T-cell activation, in pressure overload-induced cardiac hypertrophy. We generated a cardiac-specific Epi64c conditional knockout mouse strain and showed that loss of Epi64c remarkably exacerbates pressure overload-induced cardiac hypertrophy. In contrast, EPI64C gain-of-function in cardiomyocyte-specific Epi64c transgenic mice exerts potent protective effects against cardiac hypertrophy. Mechanistically, the cardioprotective effects of EPI64C are largely attributed to the disrupted calcineurin signaling but are independent of its Ras suppressive capability. Molecular studies have indicated that the 406 to 446 C-terminal amino acids in EPI64C directly bind to the 287 to 337 amino acids in the catalytic domain of calcineurin, which is responsible for the EPI64C-mediated suppressive effects. We further extrapolated our studies to cynomolgus monkeys and showed that gene therapy based on lentivirus-mediated EPI64C overexpression in the monkey hearts blunted pressure overload-induced cardiac hypertrophy. Our study thus identified EPI64C as a novel negative regulator in cardiac hypertrophy by targeting calcineurin signaling and demonstrated the potential of gene therapy and drug development for treating cardiac hypertrophy. © 2016 American Heart Association, Inc.

  4. 1st paleomagnetic investigation of Nubia Sandstone at Kalabsha, south Western Desert of Egypt

    Science.gov (United States)

    Mostafa, R.; Khashaba, A.; El-Hemaly, I. A.; Takla, E. M.; Abdel Aal, E.; Odah, H.

    2016-06-01

    Two profiles have been sampled from the Nubia Sandstone at Aswan, south Western Desert: the 1st profile has been taken from Abu Aggag Formation and the 2nd one was from Sabaya Formation (23.25 °N, 32.75 °E). 136 oriented cores (from 9 sites) have been sampled. Abu Aggag Formation is of Late Cretaceous (Turonian) and Sabaya Formation is of early Cretaceous (Albian-Cenomanian). The studied rocks are subjected to rock magnetic measurements as well as demagnetization treatment. It has been found that hematite is the main magnetic mineral in both formations. Four profile sections from Abu Aggag Formation, yielded a magnetic component with D = 352.7°, I = 36.6° with α95 = 5.2° and the corresponding pole lies at Lat. = 82.8 °N and Long. = 283.1 °E. Five profile sections from Sabaya Formation, yielded a magnetic component with D = 348.6°, I = 33.3° with α95 = 5.8° and the corresponding pole lies at Lat. = 78.3 °N and Long. = 280.4 °E. The obtained paleopole for the two formations lies at Lat. = 80.5 °N and Long. = 281.7 °E. The obtaind magnetic components are considered primary and the corresponding paleopole reflects the age of Nubia Sandstone when compared with the previously obtained Cretaceous poles for Egypt.

  5. SEMANTICS POETIC STYLE IN THE ESTIMATES OF RUSSIAN CRITICISM 1st HALF OF THE XIX CENTURY

    Directory of Open Access Journals (Sweden)

    I. B. Serebrianaia

    2014-01-01

    Full Text Available The article is devoted to the analysis of the 19th century critical judgments about the language of poetic works. Such statements reflect current cultural and speech problems of the epoch, the difficulties of language standardization, linguistic habits and tastes and are very important for the linguistics. The analysis of Russian literary criticism of the 1st half of the 19th century brings one to the conclusion that the reviewers, exacting and very sensitive to lexical and semantic correctness of fiction, meticulously recorded inaccuracies in the use of poetic words, i. e. romantically colored, mostly archaic words having a symbolic function. Outdated tokens, such as chelo ‘ forehead ‘, sen’ ‘ cover ‘, kushcha ‘ hut ‘, etc., as a result of their intense poetic figurative-personalized use often lost their semantic clarity? Which disagreed with standard rules and caused an extremely negative and sometimes ironic reaction of critics. This article describes instances of reviewers’ negative reactions to the use of the archaism chelo in the meanings ‘ head, face ‘; sen’ in the meanings ‘mental tranquility, shelter ‘; kushcha ‘foliage, thicket’, etc. A good illustration of semantic “vagueness” of archaic Church Slavonic vocabulary is the discussion between A. S. Pushkin and M. A. Dmitriev concerning semantic content of the poetic word лоно ‘ depth’, or ‘surface, bosom’. Such phenomena manifest the tendency for losing semantic clarity and then rapid withdrawal of high frequency words to the periphery.

  6. The relation between 1st grade grey matter volume and 2nd grade math competence.

    Science.gov (United States)

    Price, Gavin R; Wilkey, Eric D; Yeo, Darren J; Cutting, Laurie E

    2016-01-01

    Mathematical and numerical competence is a critical foundation for individual success in modern society yet the neurobiological sources of individual differences in math competence are poorly understood. Neuroimaging research over the last decade suggests that neural mechanisms in the parietal lobe, particularly the intraparietal sulcus (IPS) are structurally aberrant in individuals with mathematical learning disabilities. However, whether those same brain regions underlie individual differences in math performance across the full range of math abilities is unknown. Furthermore, previous studies have been exclusively cross-sectional, making it unclear whether variations in the structure of the IPS are caused by or consequences of the development of math skills. The present study investigates the relation between grey matter volume across the whole brain and math competence longitudinally in a representative sample of 50 elementary school children. Results show that grey matter volume in the left IPS at the end of 1st grade relates to math competence a year later at the end of 2nd grade. Grey matter volume in this region did not change over that year, and was still correlated with math competence at the end of 2nd grade. These findings support the hypothesis that the IPS and its associated functions represent a critical foundation for the acquisition of mathematical competence.

  7. Calibration and commutability assessment of the 1st International Standard for Diphtheria Antitoxin Human.

    Science.gov (United States)

    Stickings, Paul; Rigsby, Peter; Coombes, Laura; von Hunolstein, Christina; Ralli, Luisa; Pinto, Antonella; Sesardic, Dorothea

    2013-11-01

    The 1st International Standard for Diphtheria Antitoxin Human (coded 10/262) was established by the World Health Organization Expert Committee on Biological Standardization in 2012. This paper describes the production, characterization and calibration of the new standard which is intended for use in the standardization of assays used to measure diphtheria antibody responses in human serum. The new standard was calibrated in terms of the International Standard for Diphtheria Antitoxin Equine in an international collaborative study. A total of 8 participants from 8 different countries performed in vivo and/or in vitro toxin neutralization tests and returned data that was used to assign units to the proposed new standard. The new standard has a diphtheria antitoxin potency of 2 IU/ampoule and is predicted to be stable. A follow up study was performed to assess commutability of the new standard. The follow up study was an existing external quality assessment, modified to include the new standard. Results obtained suggest that the new standard is commutable, showing comparable behaviour to native human serum samples in the majority of the assays compared, and is therefore suitable for use as a reference preparation in assays used to measure the level of anti-diphtheria antibodies in human serum.

  8. 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop: April 5-7, 2011

    Energy Technology Data Exchange (ETDEWEB)

    2011-10-01

    The U.S. marine energy industry is actively pursuing development of offshore wind and marine hydrokinetic (MHK) energy systems. Experience in the wind energy sector demonstrates that new technology development requires thorough measurement and characterization of the environmental conditions prevalent at installation sites and of technology operating in the field. Presently, there are no turn-key instrumentation system solutions that meet the measurement needs of the marine energy industry. The 1st Advanced Marine Renewable Energy Instrumentation Experts Workshop brought together technical experts from government laboratories, academia, and industry representatives from marine energy, wind, offshore oil and gas, and instrumentation developers to present and discuss the instrumentation needs of the marine energy industry. The goals of the meeting were to: (1) Share the latest relevant knowledge among technical experts; (2) Review relevant state-of-the-art field measurement technologies and methods; (3) Review lessons learned from recent field deployments; (4) Identify synergies across different industries; (5) Identify gaps between existing and needed instrumentation capabilities; (6) Understand who are the leading experts; (7) Provide a forum where stakeholders from the marine energy industry could provide substantive input in the development of new marine energy field deployable instrumentation packages.

  9. Analysis of stresses on the 1st phase support of the monitoring drifts of the radioactive waste repository

    Directory of Open Access Journals (Sweden)

    Hatala Jozef

    1999-09-01

    Full Text Available In the paper, the stability analysis of the radioactive waste repository monitoring drifts’ support by means of the numerical modelling - finite element method is described. The aim of this analysis was to judge to what extent the designed 1st phase support’s parameters correspond with the geomechanical conditions determined by the engineering-geological survey.

  10. Italian research on Antarctic atmosphere: 1st workshop. Ricerche italiane sull'atmosfera antartica: 1o workshop

    Energy Technology Data Exchange (ETDEWEB)

    Colacino, M. (ed.); Giovannelli, G. (ed.); Stefanutti, L. (ed.)

    1989-01-01

    The papers and reports, presented at this 1st workshop on 'Italian research on antarctic atmosphere', deal with several main topics: meteorology and climatology, aerosol and tropospheric clouds, planetary boundary layer, chemical-physic stratospheric property, aeronomy. They define the stage of development of Italian research in this area after 3 years of activity in Antarctica.

  11. Sun-Earth Day:2008 Space Weather Around the World Total Solar Eclipse of 2008 August 1st in Siberia

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A very unique astronomical phenomenon will take place on the territory of Russia on the 1st August 2008.The total eclipse with a width of about 250 km will cross the Western Siberia from the north to the south,then will cross the Altai Mountains and will go further to the difficult to access regions of China and Mongolia.

  12. Addressing learning difficulties in Newtons 1st and 3rd Laws through problem based inquiry using Easy Java Simulation

    CERN Document Server

    Goh, Khoon Song Aloysius; Yip, Kim Wah; Toh, Ping Yong Jeffrey; Lye, Sze Yee

    2013-01-01

    We develop an Easy Java Simulation (EJS) model for students to visualize Newtons 1st and 3rd laws, using frictionless constant motion equation and a spring collision equation during impact. Using Physics by Inquiry instructional (PbI) strategy, the simulation and its problem based inquiry worksheet aim to enhance learning of these two Newtonian concepts. We report results from Experimental (N=62 students) and Control (N=67) Groups in 11 multiple choice questions pre and post tests, conducted by three teachers in the school. Results suggest, at 95 percent confidence level, significant improvement for concept of Newtons 1st Law while not so for Newtons 3rd Law. A Focus Group Discussion revealed students confirming the usefulness of the EJS model in visualizing the 1st Law while not so much for the 3rd Law. We speculate the design ideas for constant velocity motion in the computer model coupled with the PbI worksheet did allow for making sense and experiencing of the 1st Law, where traditional pen-paper represen...

  13. Aquaporin-2 excretion and renal function during the 1st week of life in preterm newborn infants.

    NARCIS (Netherlands)

    Iacobelli, S.; Addabbo, F.; Bonsante, F.; Procino, G.; Tamma, G.; Acito, A.; Esposito, L.; Svelto, M.; Valenti, G.

    2006-01-01

    In many preterm infants, a characteristic pattern of fluid and electrolyte homeostasis occurs during the 1st week of life, consisting of three phases: prediuretic, diuretic, and postdiuretic. In this study, we evaluated the possible role of aquaporin-2 (AQP2) in renal concentrating ability and corre

  14. Jordanian Kindergarten and 1st-Grade Teachers' Beliefs about Child-Based Dimensions of School Readiness

    Science.gov (United States)

    Fayez, Merfat; Ahmad, Jamal Fathi; Oliemat, Enass

    2016-01-01

    The purpose of this study was to explore the beliefs of Jordanian kindergarten and 1st-grade teachers regarding six child-based dimensions of school readiness: academic knowledge, basic thinking skills, socioemotional maturity, physical well-being and motor development, self-discipline, and communication skills. Questionnaires were used to collect…

  15. The 1st Kalmyk Regiment Formation and Its Military Experience in the War of 1812–1814

    Directory of Open Access Journals (Sweden)

    Utash B. Ochirov

    2012-11-01

    Full Text Available The war of 1812–1814 has become a challenge for the Russian Empire. To meet the attack of “The Grand Armee”, great forces were called up, including the regiments, formed from non-Russian ethnic groups. The 1st Kalmyk Regiment (Commander – Captain Dzhamba-taysha Tundutov was one of these regiments. It should be noted that the historiography of Napoleonic Wars starting from the XIX century was interested in irregular regiments far less than in the regular ones, that is why their history abounded with unexplored facts. Stavropol, 1st and 2nd Kalmyk Regiments went through a glorious way in the war of 1812–1814, but, unfortunately, for a number of reasons it was misrepresented in the history of the XХ century. The 1st Kalmyk Regiment was the most unlucky, as its military experience was far from being true due to the mistakes, made by the researchers. The article is focused on the history of the 1st Kalmyk Regiment formation and its military experience in the war of 1812–1814. The work is chiefly based on the Russian State Military History Archive data.

  16. Chairs' Introduction to APOS2008——The 1st Asia-Pacific Optical Fiber Sensors Conference

    Institute of Scientific and Technical Information of China (English)

    Yun-Jiang Rao

    2008-01-01

    @@ This special issue in the Journal of Electronic Science & Technology of China (JESTC) contains the selected papers presented at the 1st Asia-Pacific Optical Fiber Sensors Conference (APOS2008) organized by University of Electronic Science and Technology of China and Chongqing University, China.

  17. Advanced Epi Tools for Gallium Nitride Light Emitting Diode Devices

    Energy Technology Data Exchange (ETDEWEB)

    Patibandla, Nag; Agrawal, Vivek

    2012-12-01

    Over the course of this program, Applied Materials, Inc., with generous support from the United States Department of Energy, developed a world-class three chamber III-Nitride epi cluster tool for low-cost, high volume GaN growth for the solid state lighting industry. One of the major achievements of the program was to design, build, and demonstrate the world’s largest wafer capacity HVPE chamber suitable for repeatable high volume III-Nitride template and device manufacturing. Applied Materials’ experience in developing deposition chambers for the silicon chip industry over many decades resulted in many orders of magnitude reductions in the price of transistors. That experience and understanding was used in developing this GaN epi deposition tool. The multi-chamber approach, which continues to be unique in the ability of the each chamber to deposit a section of the full device structure, unlike other cluster tools, allows for extreme flexibility in the manufacturing process. This robust architecture is suitable for not just the LED industry, but GaN power devices as well, both horizontal and vertical designs. The new HVPE technology developed allows GaN to be grown at a rate unheard of with MOCVD, up to 20x the typical MOCVD rates of 3{micro}m per hour, with bulk crystal quality better than the highest-quality commercial GaN films grown by MOCVD at a much cheaper overall cost. This is a unique development as the HVPE process has been known for decades, but never successfully commercially developed for high volume manufacturing. This research shows the potential of the first commercial-grade HVPE chamber, an elusive goal for III-V researchers and those wanting to capitalize on the promise of HVPE. Additionally, in the course of this program, Applied Materials built two MOCVD chambers, in addition to the HVPE chamber, and a robot that moves wafers between them. The MOCVD chambers demonstrated industry-leading wavelength yield for GaN based LED wafers and industry

  18. Artificial epi-Retinal Prosthesis (AeRP)

    Science.gov (United States)

    Doorish, John F.

    2006-09-01

    There are several research projects going on around the world, which are attempting to develop a prosthetic device to restore sight to the blind. This paper describes the efforts of Second Sight of New York, Inc. The device being developed is called an Artificial epi-Retinal Prosthesis (AeRP), which is basically a small optical computer that fits into the intraocular space of the eye. The AeRP is designed to draw light into the device by specially designed fibre optics. The light is ‘digitized’ by the fibre optic system and then directed to individual photodiode cells making up concentric cylinders thus providing several hundred photodiode cells in the device. The produced electrical stimulation from each cell is then delivered to the retinal ganglion cells by a specially designed delivery system utilizing electrically conducting polymer strands (ECP), which sit on an ‘umbrella’ at the back of the device. The retinal ganglion cells receive the electrical stimulation, which would then be transmitted through the visual system of the brain. There are several innovations in this approach as compared to the other projects. They include, first the design, which will allow for a high number of PC to produce electrical stimulation that will stimulate multiple RGC per PC; the use of the ECP strands has not been used in such an approach before this. Tests have revealed that nerve cells have a good affinity for the material of the ECP. The use of the ECP as well as the fact that the AeRP is completely photovoltaic, with no external power sources, implies that there will not be high heat build-up in the back of the eye, which might damage RGC. A smaller version of the AeRP called the Mini epi-Retinal Prosthesis (MeRP) is the subject of a complimentary paper. It is being built now and will be tested in cell culture studies to determine the efficacy of the design and materials. No actual implants have been performed yet.

  19. Comparison of the results of T-Test from different versions of Epi Info

    Institute of Scientific and Technical Information of China (English)

    Junke Tang; Jinliang Zhu

    2005-01-01

    Objective: To take advantage of Epi Info to manage and analyze disease data. Methods: After selecting the living examples for independent sample T-Test, Epi Info 5.00, 5.01a(Chinese), 6.00, 6.04 b, 6.04 d, 2000, 2002(Chinese)were used to do the independent sample T-Test on the two living examples. Then, Intercooled Stata7, Microsoft Excel(2002) and SPSS 10.0 for Windows were used to verify the results. Results: The statistical results from the Epi Info 5.00, 5.01a(Chinese) and 6.00 were the same while that from Epi Info 6.04 b, 6.04 d, 2000,2002 (Chinese), Intercooled Stata7, Microsoft Excel(2002) and SPSS 10.0 for Windows were identical In independent sample T-Test,. But the former result is different with the latter. Conclusion: There was an error in the result of T-Test from Epi Info 6.00 and former versions. Thus, it's important to be alert to select the versions of Epi Info to manage and analyze disease data. On the other hand, it's also quite pivotal to distinguish the adopted Epi Info versions when referring to the articles ane use the statistical results.

  20. 1st paleomagnetic investigation of Nubia Sandstone at Kalabsha, south Western Desert of Egypt

    Directory of Open Access Journals (Sweden)

    R. Mostafa

    2016-06-01

    Full Text Available Two profiles have been sampled from the Nubia Sandstone at Aswan, south Western Desert: the 1st profile has been taken from Abu Aggag Formation and the 2nd one was from Sabaya Formation (23.25 °N, 32.75 °E. 136 oriented cores (from 9 sites have been sampled. Abu Aggag Formation is of Late Cretaceous (Turonian and Sabaya Formation is of early Cretaceous (Albian–Cenomanian. The studied rocks are subjected to rock magnetic measurements as well as demagnetization treatment. It has been found that hematite is the main magnetic mineral in both formations. Four profile sections from Abu Aggag Formation, yielded a magnetic component with D = 352.7°, I = 36.6° with α95 = 5.2° and the corresponding pole lies at Lat. = 82.8 °N and Long. = 283.1 °E. Five profile sections from Sabaya Formation, yielded a magnetic component with D = 348.6°, I = 33.3° with α95 = 5.8° and the corresponding pole lies at Lat. = 78.3 °N and Long. = 280.4 °E. The obtained paleopole for the two formations lies at Lat. = 80.5 °N and Long. = 281.7 °E. The obtaind magnetic components are considered primary and the corresponding paleopole reflects the age of Nubia Sandstone when compared with the previously obtained Cretaceous poles for Egypt.

  1. Patterns of Irregular Burials in Western Europe (1st-5th Century A.D.)

    Science.gov (United States)

    Milella, Marco; Mariotti, Valentina; Belcastro, Maria Giovanna; Knüsel, Christopher J.

    2015-01-01

    Background Irregular burials (IB—burials showing features that contrast with the majority of others in their geographic and chronological context) have been the focus of archaeological study because of their relative rarity and enigmatic appearance. Interpretations of IB often refer to supposed fear of the dead or to social processes taking place in time-specific contexts. However, a comprehensive and quantitative analysis of IB for various geographical contexts is still lacking, a fact that hampers any discussion of these burials on a larger scale. Methods Here, we collected a bibliographic dataset of 375 IB from both Britain and Continental Europe, altogether spanning a time period from the 1st to the 5th century AD. Each burial has been coded according to ten dichotomous variables, further analyzed by means of chi-squared tests on absolute frequencies, non-metric multidimensional scaling, and cluster analysis. Results Even acknowledging the limits of this study, and in particular the bias represented by the available literature, our results point to interesting patterns. Geographically, IB show a contrast between Britain and Continental Europe, possibly related to historical processes specific to these regions. Different types of IB (especially prone depositions and depositions with the cephalic extremity displaced) present a series of characteristics and associations between features that permit a more detailed conceptualization of these occurrences from a socio-cultural perspective that aids to elucidate their funerary meaning. Conclusions and Significance Altogether, the present work stresses the variability of IB, and the need to contextualize them in a proper archaeological and historical context. It contributes to the discussion of IB by providing a specific geographic and chronological frame of reference that supports a series of hypotheses about the cultural processes possibly underlying their occurrence. PMID:26115408

  2. After Meeting: The 1st Maritime Pilotage/Towage Services and Technologies Congress

    Directory of Open Access Journals (Sweden)

    Adnan PARLAK

    2016-03-01

    Full Text Available The 1st Maritime Pilotage/Towage Services and Technologies Congress has been organized by UCTEA Chambers of Marine Engineers, UCTEA the Chamber of Turkish Naval Architects & Marine Engineers and Turkish Maritime Pilots’ Association at 23 October 2015, Hilton Hotel, İzmir. In the opening ceremony, two distinguished keynote speakers have presented their presentations. Captain Stein Inge DAHN who is the president of European Maritime Pilots’ Association(EMPA has given a fulfilling speech on switching to hand steering by giving an example from the automation in the Aviation Industry. The second keynote speaker Robert G. Allan, who is the Executive Chairman of Robert Allan Ltd., has given a leading speech under the title of “The State of the Art in Escort Tug Technology -2015”. Five key points have come into prominence during the symposium. To summarize: • To prevent ships and cargos which are exposed to damages, • To prevent marine and coastal environments against pollution due to collisions, • To establish fast, secure and well organized sea traffic • To develop new escort tug technologies and pilotage softwares in the national level which is open to competitions in the international markets. • Opening maritime pilotage into the competitions in the areas which needs special expertize. In my opinion, the topics discussed in the symposium have the attendants won a wide horizon in the field. However, the presentations related to Escort Tug Technologies were insufficient from the standpoint of both quality and numbers of the manuscripts presented. Due to importance of Maritime Pilotage/Towage Services and Technologies, much more attentions must be taken in the national and international levels and sustainability of the symposium must be provided .

  3. Prevalence of injuries in Wushu competition during the 1st Asian Martial Arts Games 2009.

    Science.gov (United States)

    Yiemsiri, Pichet; Wanawan, Amarin

    2014-02-01

    To determine the prevalence and characteristic of injuries in Wushu Competition during the IP' Asian MartialArts Games 2009. Sixty international athletes (38 males) participating in Wushu Competition during the 1st Asian Martial Arts Games 2009. Injuries were recorded on injury report forms to document any injuries seen and treatment provided by tournament physician during competitions. The injury forms described the athlete s causes, type, site, and severity of the injuries. There were 60 international athletes the average age were 22.49 +/- 3.75 years. The prevalence ofinjuries was 228.07/ 1000 athlete exposure (AE). The prevalence in males andfemales was 161.76/1000 AE and 326.09/1000 AE, respectively. The most common injured body parts in males were lower extremities 102.94/1000 AE, followed by head and face injuries 58.82/1000 AE. The most common injured body parts in females were lower extremities 282.61/1000 AE. The most common types of injuries in males were contusions 58.82/1000 AE, concussion 29.41/1000 AE and strain-sprain 29.41/1000 AE. In females the most common type of injury were contusion 195.65/1000 AEfollowed by strain-sprain 130.43/1000 AE. The most common mechanism of injury in males werereceiving a punch 58.82/1000 AE, receiving a kick 44.12/1000 AE and delivering a kick 44.12/1000 AE. Meanwhile, in females common mechanisms were receiving a kick 152.17/1000 AE followed by delivering a kick 130.43/1000 AE. High prevalence of injuries in Wushu competition during the 1" Asian MartialArts Games 2009 revealedfemale injuries were higher than male and had a higher prevalence compared with Muay Thai or Taekwondo competitions.

  4. Meteorological features associated with unprecedented precipitation over India during 1st week of March 2015

    Indian Academy of Sciences (India)

    Naresh Kumar; M Mohapatra; A K Jaswal

    2017-07-01

    Unprecedented precipitation along with heavy falls occurred over many parts of India from 28th February to 2nd March 2015. Many of the stations of northwest and central India received an all time high 24 hr cumulative precipitation of March during this period. Even the national capital, New Delhi, broke all the previous historical 24 hr rainfall records of the last 100 years to the rainfall record in March 2015. Due to this event, huge loss to agricultural and horticultural crops occurred in several parts of India. In the present study, an attempt is made to understand the various meteorological features associated with this unprecedented precipitation event over India. It occurred due to the presence of an intense western disturbance (WD) over Afghanistan and neighbouring areas in the form of north–south oriented deep trough in westerlies in middle and upper tropospheric levels with its southern end deep in the Arabian Sea, which pumped huge moisture feed over Indian region. Also, there was a jet stream with core wind speed up to 160 knots that generated high positive divergence at upper tropospheric level over Indian region; along with this there was high magnitude of negative vertical velocity and velocity convergence were there at middle tropospheric level. It caused intense upward motion and forced lower levels air to rise and strengthen the lower levels cyclonic circulations (CCs)/Lows. Moreover, the induced CCs/Lows at lower tropospheric levels associated with WD were more towards south of its normal position. Additionally, there was wind confluence over central parts of India due to westerlies in association with WD and easterlies from anticyclone over north Bay of Bengal. Thus, intense WD along with wind confluence between westerlies and easterlies caused unprecedented precipitation over India during the 1st week of March 2015.

  5. A simple design rule for 1st order form-closure of underactuated hands

    Directory of Open Access Journals (Sweden)

    S. Krut

    2011-02-01

    Full Text Available The property of form-closure of a grasp, as generally defined in the literature, is based on the assumption that contact points between the hand and the object are fixed in space. However, this assumption is false when considering a grasp exerted by an underactuated hand, since in this case, it is not possible to control the position of each phalanx independently. In spite of researchers' interest in studying form-closure, none of the available published work on this subject takes into consideration the particular kinematics of underactuated hands. Actually, there are few available tools to qualify or quantify the stability of a grasp exerted by an underactuated hand, thus the design of underactuated hands mostly results from an intuitive approach. This paper aims to reduce this gap.

    A classification of underactuated hands is proposed, based on the expression of contact forces. This highlights the influence of non-backdrivable mechanisms introduced in the transmission of the closing motion of the hand on the stability of the grasp. The way to extend the original definition of form-closure to underactuated grasps is illustrated. A more general definition is formulated, which checks the stability of the set "object + hand". Using this new definition, a simple rule is proposed for designing a hand capable of achieving 1st order form-closed grasps.

    This paper was presented at the IFToMM/ASME International Workshop on Underactuated Grasping (UG2010, 19 August 2010, Montréal, Canada.

  6. PREFACE: 1st Conference on Light and Particle Beams in Materials Science 2013 (LPBMS2013)

    Science.gov (United States)

    Kumai, Reiji; Murakami, Youichi

    2014-04-01

    From 29-31 August 2013, the 1st International Conference on Light and Particle Beams in Materials Science, LPBMS 2013, took place in the Tsukuba International Congress Center in the city of Tsukuba, Japan. The conference was a continuation of the international series Synchrotron Radiation in Materials Science (SRMS), which started in 1994. The last one, SRMS-7, was held in Oxford UK 11-14 July 2010, where the International Advisory Committee (IAC) recommended the conference be enlarged to incorporate Materials Research from Neutron, Muon, and Slow Positron Sources, as well as the science emerging from Synchrotron Light Sources. The conference brought together contributions from academics and industrial researchers with a diverse background and experience from the physics, chemistry and engineering communities. The topics covered in the LPBMS2013 include strongly correlated electron systems, magnetism and magnetic materials, soft matter, interface and surface defects, catalysts, biomaterials, and ceramics. In the 3-day scientific program, the conference consisted of 9 plenary talks, 33 invited talks, 20 oral presentations, and 126 poster presentations. We are pleased to publish the proceedings of the LPBMS2013 in this volume of Journal of Physics: Conference Series. This volume contains 58 papers representing the work that was presented and discussed at the conference. We hope that this volume will promote further development of this interdisciplinary materials research emerging from synchrotron light, neutron, muon, and slow positron sciences. Finally, we would like to thank the International Advisory Committee (Chair: Professor G N Greaves), sponsors, all the participants and contributors for making possible this international meeting of researchers. Reiji Kumai & Youichi Murakami Conference photograph Details of the program and organizing committees are available in the pdf

  7. Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative.

    Science.gov (United States)

    Hendriks, Hans R; Govaerts, Anne-Sophie; Fichtner, Iduna; Burtles, Sally; Westwell, Andrew D; Peters, Godefridus J

    2017-07-11

    The European NCI compounds programme, a joint initiative of the EORTC Research Branch, Cancer Research Campaign and the US National Cancer Institute, was initiated in 1993. The objective was to help the NCI in reducing the backlog of in vivo testing of potential anticancer compounds, synthesised in Europe that emerged from the NCI in vitro 60-cell screen. Over a period of more than twenty years the EORTC-Cancer Research Campaign panel reviewed ∼2000 compounds of which 95 were selected for further evaluation. Selected compounds were stepwise developed with clear go/no go decision points using a pharmacologically directed programme. This approach eliminated quickly compounds with unsuitable pharmacological properties. A few compounds went into Phase I clinical evaluation. The lessons learned and many of the principles outlined in the paper can easily be applied to current and future drug discovery and development programmes. Changes in the review panel, restrictions regarding numbers and types of compounds tested in the NCI in vitro screen and the appearance of targeted agents led to the discontinuation of the European NCI programme in 2017 and its transformation into an academic platform of excellence for anticancer drug discovery and development within the EORTC-PAMM group. This group remains open for advice and collaboration with interested parties in the field of cancer pharmacology.

  8. Annotation and query of tissue microarray data using the NCI Thesaurus

    Directory of Open Access Journals (Sweden)

    Montgomery Kelli

    2007-08-01

    Full Text Available Abstract Background The Stanford Tissue Microarray Database (TMAD is a repository of data serving a consortium of pathologists and biomedical researchers. The tissue samples in TMAD are annotated with multiple free-text fields, specifying the pathological diagnoses for each sample. These text annotations are not structured according to any ontology, making future integration of this resource with other biological and clinical data difficult. Results We developed methods to map these annotations to the NCI thesaurus. Using the NCI-T we can effectively represent annotations for about 86% of the samples. We demonstrate how this mapping enables ontology driven integration and querying of tissue microarray data. We have deployed the mapping and ontology driven querying tools at the TMAD site for general use. Conclusion We have demonstrated that we can effectively map the diagnosis-related terms describing a sample in TMAD to the NCI-T. The NCI thesaurus terms have a wide coverage and provide terms for about 86% of the samples. In our opinion the NCI thesaurus can facilitate integration of this resource with other biological data.

  9. The allo-epi-endothelial lining of the intervillous space.

    Science.gov (United States)

    Ockleford, C D

    2010-12-01

    An unusual monolayer of cells lines the interface between the basal plate and the intervillous space in human term placenta but not the chorionic villi. Our recent descriptions of it are based on advanced microscopy, phenotyping and cytogenetic approaches. The papers show that the layer is partly epithelial (ectoderm) and partly endothelial (mesoderm): it is partly derived from the fetus and partly from the mother. This first accurate description of a naturally occurring human allo-epi-endothelium (monolayer of cells derived from two embryological germ layers and two individuals) is of interest in anatomy, obstetrics and gynaecology, developmental biology, histology and immunology. The most extensive evidence for this mosaic applies to the intervillous space lining layer of the basal plate where the endothelial proportion is of the order of 50%; it extends throughout central, intermediate and peripheral parts of the basal plate and is a consistent feature of the intervillous space lining of the chorionic plate also. Its presence lining chorionic plate is noteworthy as it includes the furthest parts of the sinus from the supplying and draining vessels which are endothelial lined.

  10. Decitabine: a promising epi-immunotherapeutic agent in solid tumors.

    Science.gov (United States)

    Li, Xiang; Mei, Qian; Nie, Jing; Fu, Xiaobing; Han, Weidong

    2015-03-01

    The incidence of malignancies is increasing worldwide. Despite early detection, surgical resection, chemotherapy and radiotherapy, numerous patients continue to die from metastasis or recurrence. The immune system has the capacity to eradicate cancer cells; however, many tumors, especially solid tumors, present considerable challenges that render immune cells ineffectual, making cancer cells almost 'invisible' to the immune system. Compelling evidence has demonstrated that DNA methylation is involved in tumor development and progression, leading to the impaired immunogenicity and immune recognition of cancer cells. The hypomethylating agent decitabine has been shown to have therapeutic effects in malignancies and exhibits an effective immune efficacy in eliminating cancer cells. Based on the hypomethylating and immune remodeling effects of decitabine, we propose in this review that decitabine can be considered an epi-immunotherapeutic agent. We summarize the results of recent preclinical studies and clinical trials for decitabine and discuss the connections among its hypomethylating effect, immune-activated mechanisms and clinical activity in solid tumors, keeping in mind the goal of optimizing dosing schedules.

  11. Molecular cloning and functional analysis of a 10-epi-junenol synthase from Inula hupehensis.

    Science.gov (United States)

    Gou, Jun-Bo; Li, Zhen-Qiu; Li, Chang-Fu; Chen, Fang-Fang; Lv, Shi-You; Zhang, Yan-Sheng

    2016-09-01

    Junenol based-eudesmanolides have been detected in many compositae plant species and were reported to exhibit various pharmacological activities. So far, the gene encoding junenol synthase has never been isolated. Here we report the molecular cloning and functional analysis of a 10-epi-junenol synthase from Inula hupehensis (designated IhsTPS1). IhsTPS1 converts the substrate farnesyl diphosphate into multiple sesquiterpenes with the product 10-epi-junenol being predominant. The transcript levels of IhsTPS1 correlate well with the accumulation pattern of 10-epi-junenol in I. hupehensis organs, supporting its biochemical roles in vivo.

  12. Innovacions amb blogs: desenvolupament de competències del futur mestre i benestar subjectiu docent

    Directory of Open Access Journals (Sweden)

    Mª Rosario Neira Piñeiro

    2012-12-01

    Full Text Available Es descriuen tres experiències innovadores del Grau de Maestro amb blogs, orientades al desenvolupament de competències específiques i transversals: un blog de ressenyes literàries infantils; una revista digital com a espai per a la investigació i el treball col·laboratiu; i un i-portafolio per visibilizar pràctiques, avaluar progressos en l'aprenentatge i desenvolupar tutories. Es va constatar en totes elles una alta participació, motivació i implicació, i el desenvolupament de competències d'ordre superior, com les habilitats comunicatives, digitals, d'anàlisis i síntesis…. Amb això, el professorat va experimentar un alt grau de benestar subjectiu, vinculat amb la seva satisfacció en relació a les innovacions realitzades.

  13. Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora.

    Science.gov (United States)

    Yenjai, Chavi; Wanich, Suchana

    2010-05-01

    Flavones 1-4 isolated from Kaempferia parviflora were used for structural modification. Sixteen flavonoid derivatives, including four new derivatives, were synthesized and evaluated for cytotoxicity against KB and NCI-H187 cell lines. Flavanones 2a-4a demonstrated higher cytotoxic activity than the parent compounds. Cytotoxicity against KB cell line of oxime 1c was about 7 times higher than the ellipticine standard. Interestingly, oximes 1c and 2c exhibited highly potent cytotoxicity against NCI-H187 cell line with IC(50) values of 0.014 and 0.23 microM, respectively. Oximes 4c and 5c showed strong cytotoxicity against NCI-H187 cell line with IC(50) values of 4.04 and 2.32 microM, respectively. 2010 Elsevier Ltd. All rights reserved.

  14. SU-E-T-188: Commission of World 1st Commercial Compact PBS Proton System

    Energy Technology Data Exchange (ETDEWEB)

    Ding, X; Patel, B; Song, X; Syh, J; Syh, J; Zhang, J; Freund, D; Rosen, L; Wu, H [Willis-Knighton Medical Center, Shreveport, LA (United States)

    2015-06-15

    Purpose: ProteusONE is the 1st commercial compact PBS proton system with an upstream scanning gantry and C230 cyclotron. We commissioned XiO and Raystation TPS simultaneously. This is a summary of beam data collection, modeling, and verification and comparison without range shiter for this unique system with both TPS. Methods: Both Raystation and XiO requires the same measurements data: (i) integral depth dose(IDDs) of single central spot measured in water tank; (ii) absolute dose calibration measured at 2cm depth of water with mono-energetic 10×10 cm2 field with spot spacing 4mm, 1MU per spot; and (iii) beam spot characteristics in air at 0cm and ± 20cm away from ISO. To verify the beam model for both TPS, same 15 cube plans were created to simulate different treatment sites, target volumes and positions. PDDs of each plan were measured using a Multi-layer Ionization Chamber(MLIC), absolute point dose verification were measured using PPC05 in water tank and patient-specific QA were measured using MatriXX PT, a 2D ion chamber array. Results: All the point dose measurements at midSOBP were within 2% for both XiO and Raystation. However, up to 5% deviations were observed in XiO’s plans at shallow depth while within 2% in Raystation plans. 100% of the ranges measured were within 1 mm with maximum deviation of 0.5 mm. 20 patient specific plan were generated and measured in 3 planes (distal, proximal and midSOBP) in Raystation. The average of gamma index is 98.7%±3% with minimum 94% Conclusions: Both TPS were successfully commissioned and can be safely deployed for clinical use for ProteusONE. Based on our clinical experience in PBS planning, user interface, function and workflow, we preferably use Raystation as our main clinical TPS. Gamma Index >95% at 3%/3 mm criteria is our institution action level for patient specific plan QAs.

  15. PREFACE: 1st International Conference on Sensing for Industry, Control, Communication & Security Technologies

    Science.gov (United States)

    Shuja Syed, Ahmed

    2013-12-01

    The 1st International Conference on Sensing for Industry, Control, Communication & Security Technologies (ICSICCST-2013), took place in Karachi, Pakistan, from 24-26 June 2013. It was organized by Indus University, Karachi, in collaboration with HEJ Research Institute of Chemistry, University of Karachi, Karachi. More than 80 abstracts were submitted to the conference and were double blind-reviewed by an international scientific committee. The topics of the Conference were: Video, Image & Voice Sensing Sensing for Industry, Environment, and Health Automation and Controls Laser Sensors and Systems Displays for Innovative Applications Emerging Technologies Unmanned, Robotic, and Layered Systems Sensing for Defense, Homeland Security, and Law Enforcement The title of the conference, 'Sensing for Industry, Control, Communication & Security Technologies' is very apt in capturing the main issues facing the industry of Pakistan and the world. We believe the sensing industry, particularly in Pakistan, is currently at a critical juncture of its development. The future of the industry will depend on how the industry players choose to respond to the challenge of global competition and opportunities arising from strong growth in the Asian region for which we are pleased to note that the conference covered a comprehensive spectrum of issues with an international perspective. This will certainly assist industry players to make informed decisions in shaping the future of the industry. The conference gathered qualified researchers from developed countries like USA, UK, Sweden, Saudi Arabia, China, South Korea and Malaysia etc whose expertise resulting from the research can be drawn upon to build an exploitable area of new technology that has potential Defense, Homeland Security, and Military applicability. More than 250 researchers/students attended the event and made the event great success as the turnout was 100%. An exceptional line-up of speakers spoke at the occasion. We want

  16. PREFACE: 1st International Conference on Mechanical Engineering Research 2011 (ICMER2011)

    Science.gov (United States)

    Abu Bakar, Rosli

    2012-09-01

    The year 2010 represented a significant milestone in the history of the Mechanical Engineering community with the organization of the first and second national level conferences (National Conference in Mechanical Engineering for Research, 1st and 2nd NCMER) at Universiti Malaysia Pahang on 26-27 May and 3-4 December 2010. The conferences attracted a large number of delegates from different premier academic and research institutions in the country to participate and share their research experiences at the conference. The International Conference on Mechanical Engineering Research (ICMER 2011) followed on from the first and second conferences due to good support from researchers. The ICMER 2011 is a good platform for researchers and postgraduate students to present their latest finding in research. The conference covers a wide range of topics including the internal combustion engine, machining processes, heat and mass transfer, fuel, biomechanical analysis, aerodynamic analysis, thermal comfort, computational techniques, design and simulation, automotive transmission, optimization techniques, hybrid electric vehicles, engine vibration, heat exchangers, finite element analysis, computational fluid dynamics, green energy, vehicle dynamics renewable energy, combustion, design, product development, advanced experimentation techniques, to name but a few. The international conference has helped to bridge the gap between researchers working at different institutions and in different countries to share their knowledge and has helped to motivate young scientists with their research. This has also given some clear direction for further research from the deliberations of the conference. Several people have contributed in different ways to the success of the conference. We thank the keynote speakers and all authors of the contributed papers, for the cooperation rendered to us in the publication of the CD conference proceedings. In particular, we would like to place on record our

  17. alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors.

    Science.gov (United States)

    Loughnan, M; Bond, T; Atkins, A; Cuevas, J; Adams, D J; Broxton, N M; Livett, B G; Down, J G; Jones, A; Alewood, P F; Lewis, R J

    1998-06-19

    We have isolated and characterized alpha-conotoxin EpI, a novel sulfated peptide from the venom of the molluscivorous snail, Conus episcopatus. The peptide was classified as an alpha-conotoxin based on sequence, disulfide connectivity, and pharmacological target. EpI has homology to sequences of previously described alpha-conotoxins, particularly PnIA, PnIB, and ImI. However, EpI differs from previously reported conotoxins in that it has a sulfotyrosine residue, identified by amino acid analysis and mass spectrometry. Native EpI was shown to coelute with synthetic EpI. The peptide sequence is consistent with most, but not all, recognized criteria for predicting tyrosine sulfation sites in proteins and peptides. The activities of synthetic EpI and its unsulfated analogue [Tyr15]EpI were similar. Both peptides caused competitive inhibition of nicotine action on bovine adrenal chromaffin cells (neuronal nicotinic ACh receptors) but had no effect on the rat phrenic nerve-diaphragm (muscle nicotinic ACh receptors). Both EpI and [Tyr15]EpI partly inhibited acetylcholine-evoked currents in isolated parasympathetic neurons of rat intracardiac ganglia. These results indicate that EpI and [Tyr15]EpI selectively inhibit alpha3beta2 and alpha3 beta4 nicotinic acetylcholine receptors.

  18. Clinical application of multi-shot diffusion EPI in neurological disease

    Energy Technology Data Exchange (ETDEWEB)

    Ishihara, Tetsuya; Hirata, Koichi; Kubo, Jin; Yamazaki, Kaoru [Dokkyo Univ., Mibu, Tochigi (Japan). School of Medicine; Sato, Toshihiko

    1998-05-01

    Using the multi-shot EPI method we investigated the clinical application of diffusion weighted imaging (DWI) in the diagnosis of neurological disease. The multi-shot method provided better susceptibility artifact-free DWI than the single-shot method particularly in the region of the posterior cranial fossa. DWI using the multi-shot EPI method readily shows the pyramidal tract extending from the internal capsule to the brainstems which is inaccessible by the conventional single-shot EPI method, and providing three-dimensional and distinct images of pyramidal tract changes in amyotrophic lateral sclerosis or cerebral infarction with pyramidal tract disturbance. Our findings suggest that the use of DWI with the multi-shot EPI method would provide a technique for the easy diagnosis and evaluation of various neurological diseases. (author)

  19. Epi-LASIK与Flap-free Epi-LASIK术后TGF-β 2和b-FGF的表达及其对Haze形成的影响研究%Research of TGF- β 2 and b-FGF's expression after Epi-LASIK and Flap-free Epi-LASIK on rabbit and discuss the influence on Haze

    Institute of Scientific and Technical Information of China (English)

    向一旻; 杜之渝; 刘玺; 黄正; 赵武校

    2009-01-01

    目的 观察比较Haze形成过程中的两个主要调控因子TGF-β和b-FGF,在兔Epi-LASIK与Flap-free Epi-LASIK术后表达有否差异,并探讨其对术后Haze形成的影响.方法 选用18只实验兔,建立兔Flap-free Epi-LASIK、Epi-LASIK模型,用VISX20/20B准分子激光仪作-10D切削,在无任何药物干预的情况下观察术后1、2、3月角膜Haze情况及检测比较角膜TGF-β2和b-FGF的表达水平,并探讨其对Haze形成的影响.结果 裂隙灯下观察Haze分级水平在术后1月、2月、3月差异均无统计学意义.Flap-free Epi-LASIK和Epi-LASIK术后1、2、3月TGF-β2表达差异没有统计学意义,且表现出逐渐降低的趋势.术后各时间点b-FGF表达组间比较差异无统计学意义,组内比较,b-FGF表达水平均呈现出持续升高的特点.结论 Epi-LASIK与Flap-free Epi-LASIK术后各时间点TGF-β2和b-FGF的表达情况及Haze发生程度均未见明显差异.%Objective To observe and compare the main control factor TGF-β 2 and b-FGF's expres-sion after the operation Epi-LASIK and Flap-free Epi-LASIK on rabbit during the process of Haze forming and discuss the influence on Haze forming after the operation. Methods 18 rabbits are established as Flap-free Epi-LASIK、Epi-LASIK models.Do-10D artherectomy with VISX20/20B.Then observe the Haze of 1、2、3m cornea under the situation without any drug intervention niter operation.Test and compare cornea TGF-β 2 and b-FGF expression and discuss its influence on Haze forming. Results It shows that there is no statistic mean-ing of the discrepancy of Haze after 1 month, 2 months and 3 months observing with slit lamp.The expression discrepancy of 1、2、3mTGF-β 2 niter Flap-free Epi-LASIK & Epi-LASIK is also no statistic meaning,and it presents falling trend.On each time point niter operation, comparing of each b-FGF, the discrepancy is no statis-tic meaning.Comparing in group,the expression of b-FGF presents rising trend. Conclusion There is no obvi

  20. EHS and FME Lend Their Expertise to NCI Campus Refurbishment Project | Poster

    Science.gov (United States)

    In October 2015, the NCI executive officer and the director of NCI’s Office of Space and Facilities Management (OSFM) announced a wide-ranging refurbishment plan for NCI at Frederick. Since then, a project team comprising members from the Office of Scientific Operations, the Management Operations Support Branch, OSFM, the Center for Cancer Research, the Environment, Health, and Safety (EHS) directorate, and the Facilities Maintenance and Engineering (FME) directorate have met regularly with the laboratory groups affected by the refurbishment plan. Read more...

  1. Diagnostic Marker for Improving Treatment Outcomes of Hepatitis C | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    NCI Researchers have discovered Interferon-lambda 4 (IFNL4), a protein found through analysis of genomic data. Preliminary studies indicate that this protein may play a role in the clearance of HCV and may be a new target for diagnosing and treating HCV infection. The National Cancer Institute (NCI) Division of Cancer Epidemiology and Genetics (DCEG) Immunoepidemiology Branch is seeking statements of capability or interest from parties interested in in-licensing or collaborative research to further co-develop a gene-based diagnostic for Hepatitis C virus (HepC, HCV).

  2. Connecting Genomic Alterations to Cancer Biology with Proteomics: The NCI Clinical Proteomic Tumor Analysis Consortium

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, Matthew; Gillette, Michael; Carr, Steven A.; Paulovich, Amanda G.; Smith, Richard D.; Rodland, Karin D.; Townsend, Reid; Kinsinger, Christopher; Mesri, Mehdi; Rodriguez, Henry; Liebler, Daniel

    2013-10-03

    The National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium is applying the latest generation of proteomic technologies to genomically annotated tumors from The Cancer Genome Atlas (TCGA) program, a joint initiative of the NCI and the National Human Genome Research Institute. By providing a fully integrated accounting of DNA, RNA, and protein abnormalities in individual tumors, these datasets will illuminate the complex relationship between genomic abnormalities and cancer phenotypes, thus producing biologic insights as well as a wave of novel candidate biomarkers and therapeutic targets amenable to verifi cation using targeted mass spectrometry methods.

  3. Generation of iPSC line epiHUVEC from human umbilical vein endothelial cells

    Directory of Open Access Journals (Sweden)

    Peggy Matz

    2015-11-01

    Full Text Available Human umbilical vein endothelial cells (HUVECs were used to generate the iPSC line epiHUVEC employing a combination of three episomal-based plasmids expressing OCT4, SOX2, NANOG, LIN28, c-MYC and KLF4. Pluripotency was confirmed both in vivo and in vitro. The transcriptome profile of epiHUVEC and the human embryonic stem cell line — H1 have a Pearson correlation of 0.899.

  4. EpiCollect+: linking smartphones to web applications for complex data collection projects.

    Science.gov (United States)

    Aanensen, David M; Huntley, Derek M; Menegazzo, Mirko; Powell, Chris I; Spratt, Brian G

    2014-01-01

    Previously, we have described the development of the generic mobile phone data gathering tool, EpiCollect, and an associated web application, providing two-way communication between multiple data gatherers and a project database. This software only allows data collection on the phone using a single questionnaire form that is tailored to the needs of the user (including a single GPS point and photo per entry), whereas many applications require a more complex structure, allowing users to link a series of forms in a linear or branching hierarchy, along with the addition of any number of media types accessible from smartphones and/or tablet devices (e.g., GPS, photos, videos, sound clips and barcode scanning). A much enhanced version of EpiCollect has been developed (EpiCollect+). The individual data collection forms in EpiCollect+ provide more design complexity than the single form used in EpiCollect, and the software allows the generation of complex data collection projects through the ability to link many forms together in a linear (or branching) hierarchy. Furthermore, EpiCollect+ allows the collection of multiple media types as well as standard text fields, increased data validation and form logic. The entire process of setting up a complex mobile phone data collection project to the specification of a user (project and form definitions) can be undertaken at the EpiCollect+ website using a simple 'drag and drop' procedure, with visualisation of the data gathered using Google Maps and charts at the project website. EpiCollect+ is suitable for situations where multiple users transmit complex data by mobile phone (or other Android devices) to a single project web database and is already being used for a range of field projects, particularly public health projects in sub-Saharan Africa. However, many uses can be envisaged from education, ecology and epidemiology to citizen science.

  5. Coronal MR imaging of the normal 3rd, 4th, and 5th lumbar and 1st sacral nerve roots

    Energy Technology Data Exchange (ETDEWEB)

    Hald, J.K.; Nakstad, P.H.; Hauglum, B.E. (National Hospital, Oslo (Norway). Dept. of Radiology)

    1991-05-01

    Seven healthy volunteers underwent coronal MR imaging at 1.5 tesla of the normal 3rd, 4th, and 5th lumbar, and 1st sacral nerve roots. Coronal slices, 3-mm-thick with a 0.3-mm gap between the slices were obtained (TR/TE 600/22) through the lumbar spinal canal. All the nerve roots were visible on at least one image. One can routinely expect to demonstrate the 3rd, 4th, and 5th lumbar, and 1st sacral nerve roots on T1-weighted, 3-mm-thick coronal MR scans. We found no correlation between the degree of lumbar lordosis and the lengths of the visible nerve roots. Five patients with one of the following spinal problems: anomaly, tumor, disk herniation, and failed back surgery syndrome were examined according to our protocol. In all these cases coronal MR imaging gave the correct diagnosis. (orig.).

  6. Curative observation of Epi-LASIK and LASIK for high myopia%Epi-LASIK和LASIK矫治高度近视的疗效比较

    Institute of Scientific and Technical Information of China (English)

    吴登雷; 张芹; 潘晓英

    2012-01-01

    Objective: To explore curative effect after microkeratome excimer laser epithelial keratomile -usis (Epi-LASIK) and laser in situ keratomileusis (LASIK) for high myopia, and to evaluate the safety and efficacy of Epi-LASIK and LASIK. Methods; Used United States VISX StarS4 laser, and Moria flat push type micro corneal epithelial knife making corneal flap was used for Epi -LASIK, with 0. 02% mitomycin C sponge soaked in. LASIK used Moria rotating type corneal knife making 110 μm corneal flap. The patients was followed up more than 6 months, and compared postoperative symptoms , visual acuity, refraction, and so on. Results; One week postoperative ,the proportion of UCVA≥0. 8 of Epi-LASIK (47. 8% ) was less than LASIK (95.8%) , the difference was statistically significant (x2 =27.056, P = 0.000) ; no statisti-cally significant differences were found in those of Epi-LASIK(95. 7% , 97. 8% , 97. 8%) and LASIK (97. 9% , 97. 9% , 97. 9% ) after 1,3,6 months. After 1 week, the diopter difference was statistically sig-nificant (t = -7. 123 ,P = 0. 000) ; after 1,3,6 months the diopter difference was not statistically signifi -cant. Conclusion; LASIK was still the mainstream of current treatment of myopia . Epi-LASIK was an effective and safe procedure for high myopia. Although the recovery of visual acuity was slower than LASIK , it had a wide range of operation indication , its long-term efficacy still remains to be seen.%目的:比较微型角膜刀准分子激光角膜上皮瓣下磨镶术(Epi-LASIK)与准分子激光原位角膜磨镶术(LASIK)矫治高度近视的疗效.评估两种术式的安全性和有效性.方法:采用美国VISX StarS4激光机,Epi-LASIK组采用Moria平推型微型角膜上皮刀制作角膜上皮瓣,用浸有0.02%丝裂霉素C的海绵片,LASIK组采用Moria旋转型角膜板层刀制作110 μm厚度角膜瓣.随访6月以上,对两组术后症状、视力、屈光等进行比较.结果:术后1周Epi-LASIK组裸眼视力(uncorrected visual

  7. 76 FR 28439 - Submission for OMB Review; Comment Request; NCI Cancer Genetics Services Directory Web-Based...

    Science.gov (United States)

    2011-05-17

    ... HUMAN SERVICES National Institutes of Health Submission for OMB Review; Comment Request; NCI Cancer Genetics Services Directory Web-Based Application Form and Update Mailer Summary: Under the provisions of... Collection: Title: NCI Cancer Genetics Services Directory Web-based Application Form and Update Mailer....

  8. Haydn, by Villa-Lobos: an analysis of 1st movement of Villa-Lobos's String Quartet #7

    OpenAIRE

    2012-01-01

    Este estudo analisa o 1º movimento do Quarteto de Cordas nº 7 de Villa-Lobos e investiga possíveis referências aos quartetos de cordas compostos por Franz Haydn, como Villa-Lobos sugeriu a Arnaldo Estrella.This article analyses the 1st movement of Villa-Lobos' String Quartet nº 7 and search for possible references to Franz Haydn's string quartets, as suggested by Villa-Lobos in conversations with Arnaldo Estrella.

  9. Uncertainty Requirement Analysis for the Orbit, Attitude, and Burn Performance of the 1st Lunar Orbit Insertion Maneuver

    Science.gov (United States)

    Song, Young-Joo; Bae, Jonghee; Kim, Young-Rok; Kim, Bang-Yeop

    2016-12-01

    In this study, the uncertainty requirements for orbit, attitude, and burn performance were estimated and analyzed for the execution of the 1st lunar orbit insertion (LOI) maneuver of the Korea Pathfinder Lunar Orbiter (KPLO) mission. During the early design phase of the system, associate analysis is an essential design factor as the 1st LOI maneuver is the largest burn that utilizes the onboard propulsion system; the success of the lunar capture is directly affected by the performance achieved. For the analysis, the spacecraft is assumed to have already approached the periselene with a hyperbolic arrival trajectory around the moon. In addition, diverse arrival conditions and mission constraints were considered, such as varying periselene approach velocity, altitude, and orbital period of the capture orbit after execution of the 1st LOI maneuver. The current analysis assumed an impulsive LOI maneuver, and two-body equations of motion were adapted to simplify the problem for a preliminary analysis. Monte Carlo simulations were performed for the statistical analysis to analyze diverse uncertainties that might arise at the moment when the maneuver is executed. As a result, three major requirements were analyzed and estimated for the early design phase. First, the minimum requirements were estimated for the burn performance to be captured around the moon. Second, the requirements for orbit, attitude, and maneuver burn performances were simultaneously estimated and analyzed to maintain the 1st elliptical orbit achieved around the moon within the specified orbital period. Finally, the dispersion requirements on the B-plane aiming at target points to meet the target insertion goal were analyzed and can be utilized as reference target guidelines for a mid-course correction (MCC) maneuver during the transfer. More detailed system requirements for the KPLO mission, particularly for the spacecraft bus itself and for the flight dynamics subsystem at the ground control center

  10. Draft Genome Sequences of Staphylococcus aureus AMRF1 (ST22) and AMRF2 (ST672), Ocular Methicillin-Resistant Isolates

    KAUST Repository

    Velusamy, Nithya

    2014-03-20

    Sequence type 22 (ST22) and ST672 are the two major emerging clones of community-acquired methicillin-resistant Staphylococcus aureus in India. ST672 strains were found to cause severe ocular infections. We report the draft genome sequences of two emerging strains of methicillin-resistant S. aureus, AMRF1 (ST22) and AMRF2 (ST672), isolated from patients with ocular infections.

  11. Addressing learning difficulties in Newtons 1st and 3rd Laws through problem based inquiry using Easy Java Simulation

    OpenAIRE

    Goh, Khoon Song Aloysius; Wee, Loo Kang; Yip, Kim Wah; Toh, Ping Yong Jeffrey; Lye, Sze Yee

    2013-01-01

    We develop an Easy Java Simulation (EJS) model for students to visualize Newtons 1st and 3rd laws, using frictionless constant motion equation and a spring collision equation during impact. Using Physics by Inquiry instructional (PbI) strategy, the simulation and its problem based inquiry worksheet aim to enhance learning of these two Newtonian concepts. We report results from Experimental (N=62 students) and Control (N=67) Groups in 11 multiple choice questions pre and post tests, conducted ...

  12. The Viability of Phantom Dark Energy as a Quantum Field in 1st-Order FLRW Space

    Science.gov (United States)

    Ludwick, Kevin

    2017-01-01

    In the standard cosmological framework of the 0th-order FLRW metric and the use of perfect fluids in the stress-energy tensor, dark energy with an equation-of-state parameter w - 1) do not necessarily have positive kinetic energy categorically. We then investigate the same question treating dark energy as a quantum field in 1st-order FLRW space-time and examining the expectation value of the stress-energy tensor for w < - 1 using adiabatic expansion.

  13. Educational impact of a clinical anatomy workshop on 1st-year orthopedic and rheumatology fellows in Mexico City.

    Science.gov (United States)

    Saavedra, M A; Villaseñor-Ovies, P; Harfush, L A; Navarro-Zarza, J E; Canoso, J J; Cruz-Domínguez, P; Vargas, A; Hernández-Díaz, C; Chiapas-Gasca, K; Camacho-Galindo, J; Alvarez-Nemegyei, J; Kalish, R A

    2016-05-01

    We aim to study the educational impact of a clinical anatomy workshop in 1st-year orthopedic and rheumatology fellows. First-year rheumatology fellows (N = 17) and a convenience sample of 1st-year orthopedic fellows (N = 14) from Mexico City in the 9th month of training participated in the study. The pre- and the post- workshop tests included the same 20 questions that had to be answered by identification or demonstration of relevant anatomical items. The questions, arranged by anatomical regions, were asked in five dynamic stations. Overall, the 31 participants showed an increase of correct answers, from a median of 6 (range 1 to 12) in the pre-workshop test, to a median of 14 (range 7 to 19) in the post-workshop test. In the pre-workshop test, the correct median answers were 7 (range 2 to 12) in the orthopedic fellows and 5 (range 1 to 10) in the rheumatology fellows (p = 0.297). Corresponding scores in the post-workshop were 15 (range 10 to 19) and 12 (range 7 to 18) (p = 0.026) showing a significant difference favoring the orthopedic group. Our clinical anatomy workshop was efficacious, in the short term, as a teaching instrument for 1st-year orthopedic and rheumatology fellows. The post-workshop scores, although significantly improved in both groups, particularly in the orthopedic fellows, were still suboptimal. Further refinements of our workshop might yield better results.

  14. When should orthostatic blood pressure changes be evaluated in elderly: 1st, 3rd or 5th minute?

    Science.gov (United States)

    Soysal, Pinar; Aydin, Ali Ekrem; Koc Okudur, Saadet; Isik, Ahmet Turan

    2016-01-01

    Detection of orthostatic hypotension (OH) is very important in geriatric practice, since OH is associated with mortality, ischemic stroke, falls, cognitive failure and depression. It was aimed to determine the most appropriate time for measuring blood pressure in transition from supine to upright position in order to diagnose OH in elderly. Comprehensive geriatric assessment (CGA) including Head up Tilt Table (HUT) test was performed in 407 geriatric patients. Orthostatic changes were assessed separately for the 1st, 3rd and 5th minutes (HUT1, HUT3 and HUT5, respectively) taking the data in supine position as the basis. The mean age, recurrent falls, presence of dementia and Parkinson's disease, number of drugs, alpha-blocker and anti-dementia drug use, and fasting blood glucose levels were significantly higher in the patients with versus without OH; whereas, albumin and 25-hydroxy vitamin D levels were significantly lower (pfasting blood glucose level was prominent in HUT1 as compared to HUT3 (p<0.01, p<0.05). Comparison of the patients that had OH only in HUT1, HUT3or HUT5 revealed no difference in terms of CGA parameters. These results suggests that orthostatic blood pressure changes determined at the 1st minute might be more important for geriatric practice. Moreover, 1st minute measurement might be more convenient in the elderly as it requires shorter time in practice.

  15. Preoperative and Postoperative (1st and 3rd Month Metabolic Data of Patients Who Underwent Bariatric Surgery

    Directory of Open Access Journals (Sweden)

    Nilüfer Özdemir Kutbay

    2015-03-01

    Full Text Available Purpose: The growing prevalence of obesity has become a major concern. The efficacy of medical treatment, diet and behavior therapy in morbidly obese patients is limited. Obesity surgery is a treatment option for selected morbidly obese patients. Material and Method: Data of 47 patients (n=39 women, 8 men who underwent bariatric surgery were investigated. Results: Out of 47 patients, 20 underwent Roux-en-Y gastric bypass (RYGB (43% and 27 had sleeve gastrectomy (SG (57%. The mean age of the patients was 37±9.5 (19-59 years. 17% of patients were men and 83% were women. In the analysis of data on weight that could be found for 31 out of 47 patients, we detected preoperative and postoperative (1st and 3rd month mean weight values as 125.4±15.9 kg, 112.7±13.2 kg (p<0.001 and 100.9±17.5 kg (p<0.001, respectively. In addition, the analysis of the data on mean fasting plasma glucose (FPG levels which could be found for 23 out of 47 patients, showed us that preoperative and postoperative (1st and 3rd month FPG levels were 100.9±17.5 mg/dL, 91.6±10.9 mg/dL (p=0.03 and 87.3±2.0 mg/dL, respectively. Only 1 patient had diabetes before the surgery. In the RYGB group, the mean change in weight was 12.4±5.5 kg in the 1st month and 22.2±8.6 kg in the 3rd month (compared to the weights in the preoperative period. Moreover, in the SG group, the mean change in weight was 13.7±4.5 kg in the 1st month and 23.4±5.8 kg in the 3rd month. No statistically significant difference was found between the weight changes in the 1st and the 3rd month as for surgery types. Discussion: After bariatric surgery, significant loss in weight and reduction in FPG occurred in short-term.

  16. HIV Conference to Be Held on October 21 at NCI at Frederick | Poster

    Science.gov (United States)

    By Anne Arthur, Guest Writer The HIV Drug Resistance Program Conference on “Virus Structure: Putting the Pieces Together” will be held at NCI at Frederick on October 21, 2014, from 1:00 to 5:45 p.m. in the Conference Center auditorium, Building 549.

  17. 78 FR 19496 - Submission for OMB Review; 30-day Comment Request; The National Cancer Institute (NCI...

    Science.gov (United States)

    2013-04-01

    ... HUMAN SERVICES National Institutes of Health Submission for OMB Review; 30-day Comment Request; The National Cancer Institute (NCI) SmokefreeTXT Program Evaluation SUMMARY: Under the provisions of Section... submitted ] to the Office of Management and Budget (OMB) a request to review and approve the...

  18. 78 FR 44136 - Submission for OMB review; 30-day Comment Request: National Cancer Institute (NCI) Cancer...

    Science.gov (United States)

    2013-07-23

    ... HUMAN SERVICES National Institutes of Health Submission for OMB review; 30-day Comment Request: National Cancer Institute (NCI) Cancer Nanotechnology Platform Partnership Scientific Progress Reports SUMMARY... Institutes of Health (NIH), has submitted to the Office of Management and Budget (OMB) a request for...

  19. Down-Regulation of Bcl-2 Protein Sensitizes NCI 460 Cells to Radiotherapy-Induced Apoptosis

    Institute of Scientific and Technical Information of China (English)

    Dongmei He; Yuan Zhang; Gexiu Liu

    2006-01-01

    OBJECTIVE To determine whether Bcl-2 protein down-regulation can render NCI-460 cells more susceptible to gamma radiation-induced apoptosis by treatment with antisense oligonucleotide (ASODN) against the coding region of Bcl-2 mRNA.METHODS Cell survival was determined using the trypan blue dye exclusion. Expression of the Bcl-2 protein was assayed using immunofluorescence labeling with fluoresce isothiocyanate. Apoptosis was determined by Giemsa staining and flow cytomertry.RESULTS It was found that Bcl-2 ASODN combined with radiation significantly reduced the number of viable cells (P<0.05). There was no difference in cell survival between a nonsense oligodeoxynucleotide/radiation combination and cells treated with radiation alone. Bcl-2 ASODN combined with radiation significantly inhibited expression of the Bcl-2protein in the NCI-H460 cells (P<0.05). Using Giemsa staining, cells treated with Bcl-2 ASODN combined with radiation at 72 h displayed classic apoptotic changes. Apoptotic rates of the NCI-H460 cells treated with Bcl-2 ASODN combined with radiation significantly increased (P<0.05), compared with either a nonsense oligodeoxynucleotide/radiation combination or radiation-treatment cells alone.CONCLUSION ASODN against the coding region of Bcl-2 mRNA increases radiation-induced apoptosis in NCI-H460 cells.

  20. 78 FR 2678 - Proposed Collection; Comment Request (60-Day FRN): The National Cancer Institute (NCI...

    Science.gov (United States)

    2013-01-14

    ... (OMB) for review and approval. Written comments and/or suggestions from the public and affected... comments in writing, request more information on the proposed project, or to obtain a copy of the data... developed (and is managed) by the ] National Cancer Institute (NCI) Tobacco Control Research Branch...

  1. Treatment of Prostate Cancer using Anti-androgen Small Molecules | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The National Cancer Institute seeks parties interested in collaborative research to co-develop and commercialize a new class of small molecules for the treatment of prostate cancer. General information on co-development research collaborations, can be found on our web site (http://ttc.nci.nih.gov/forms).

  2. NCI and the Chinese National Cancer Center pursue new collaborations in cancer research

    Science.gov (United States)

    CGH Director, Dr. Ted Trimble, and East Asia Program Director, Dr. Ann Chao, traveled to Beijing with Mr. Matthew Brown from the Department of Health and Human Services Office of Global Affairs to attend the Joint Meeting of the NCC and the U.S. NCI.

  3. NCI at Frederick Employees Receive Awards at the Spring Research Festival | Poster

    Science.gov (United States)

    NCI and Frederick National Laboratory staff members were among those honored at the Spring Research Festival Awards Ceremony on May 28. The ceremony was the culmination of the festival, which was sponsored by the National Interagency Confederation for Biological Research (NICBR), May 4–7. Maj. Gen. Brian Lein, commanding general, U.S. Army Medical Research and Materiel Command (USAMRMC), presented the awards.

  4. Reducing Friction: An Update on the NCIP Open Development Initiative - NCI BioMedical Informatics Blog

    Science.gov (United States)

    NCIP has migrated 132 repositories from the NCI subversion repository to our public NCIP GitHub channel with the goal of facilitating third party contributions to the existing code base. Within the GitHub environment, we are advocating use of the GitHub “fork and pull” model.

  5. HIV Conference to Be Held on October 21 at NCI at Frederick | Poster

    Science.gov (United States)

    By Anne Arthur, Guest Writer The HIV Drug Resistance Program Conference on “Virus Structure: Putting the Pieces Together” will be held at NCI at Frederick on October 21, 2014, from 1:00 to 5:45 p.m. in the Conference Center auditorium, Building 549.

  6. Protein Profile of Human Lung Squamous Carcinoma Cell Line NCI-H226

    Institute of Scientific and Technical Information of China (English)

    HAO ZHANG; NA LI; YUE CHEN; LING-YUN HUANG; YI-CHING WANG; GANG FANG; DA-CHENG HE; XUE-YUAN XIAO

    2007-01-01

    Objective To construct a database of human lung squamous carcinoma cell line NCI-H226 and to facilitate discovery of novel subtypes markers of lung cancer. Method Proteomic technique was used to analyze human lung squamous carcinoma cell line NCI-H226. The proteins of the NCI-H226 cells were separated by two-dimensional gel electrophoresis and identified by mass spectrometry. Results The results showed that a good reproducibility of the 2-D gel pattern was attained. The position deviation of matched spots among three 2-D gels was 1.95±0.53 mm in the isoelectric focusing direction,and 1.73±0.45 mm in the sodium dodecyl sulfate-polyacrylamide gel electrophoresis direction. One hundred and twenty-seven proteins, including enzymes, signal transduction proteins, structure proteins, transport proteins, etc. were characterized, of which, 29 identified proteins in NCI-H226 cells were reported for the first time to be involved in lung cancer carcinogenesis.Conclusion The information obtained from this study could provide some valuable clues for further study on the carcinogenetic mechanism of different types of lung cancer, and may help us to discover some potential subtype-specific biomarkers of lung cancer.

  7. Genetic modifiers of chromatin acetylation antagonize the reprogramming of epi-polymorphisms.

    Science.gov (United States)

    Abraham, Anne-Laure; Nagarajan, Muniyandi; Veyrieras, Jean-Baptiste; Bottin, Hélène; Steinmetz, Lars M; Yvert, Gaël

    2012-09-01

    Natural populations are known to differ not only in DNA but also in their chromatin-associated epigenetic marks. When such inter-individual epigenomic differences (or "epi-polymorphisms") are observed, their stability is usually not known: they may or may not be reprogrammed over time or upon environmental changes. In addition, their origin may be purely epigenetic, or they may result from regulatory variation encoded in the DNA. Studying epi-polymorphisms requires, therefore, an assessment of their nature and stability. Here we estimate the stability of yeast epi-polymorphisms of chromatin acetylation, and we provide a genome-by-epigenome map of their genetic control. A transient epi-drug treatment was able to reprogram acetylation variation at more than one thousand nucleosomes, whereas a similar amount of variation persisted, distinguishing "labile" from "persistent" epi-polymorphisms. Hundreds of genetic loci underlied acetylation variation at 2,418 nucleosomes either locally (in cis) or distantly (in trans), and this genetic control overlapped only partially with the genetic control of gene expression. Trans-acting regulators were not necessarily associated with genes coding for chromatin modifying enzymes. Strikingly, "labile" and "persistent" epi-polymorphisms were associated with poor and strong genetic control, respectively, showing that genetic modifiers contribute to persistence. These results estimate the amount of natural epigenomic variation that can be lost after transient environmental exposures, and they reveal the complex genetic architecture of the DNA-encoded determinism of chromatin epi-polymorphisms. Our observations provide a basis for the development of population epigenetics.

  8. Genetic modifiers of chromatin acetylation antagonize the reprogramming of epi-polymorphisms.

    Directory of Open Access Journals (Sweden)

    Anne-Laure Abraham

    2012-09-01

    Full Text Available Natural populations are known to differ not only in DNA but also in their chromatin-associated epigenetic marks. When such inter-individual epigenomic differences (or "epi-polymorphisms" are observed, their stability is usually not known: they may or may not be reprogrammed over time or upon environmental changes. In addition, their origin may be purely epigenetic, or they may result from regulatory variation encoded in the DNA. Studying epi-polymorphisms requires, therefore, an assessment of their nature and stability. Here we estimate the stability of yeast epi-polymorphisms of chromatin acetylation, and we provide a genome-by-epigenome map of their genetic control. A transient epi-drug treatment was able to reprogram acetylation variation at more than one thousand nucleosomes, whereas a similar amount of variation persisted, distinguishing "labile" from "persistent" epi-polymorphisms. Hundreds of genetic loci underlied acetylation variation at 2,418 nucleosomes either locally (in cis or distantly (in trans, and this genetic control overlapped only partially with the genetic control of gene expression. Trans-acting regulators were not necessarily associated with genes coding for chromatin modifying enzymes. Strikingly, "labile" and "persistent" epi-polymorphisms were associated with poor and strong genetic control, respectively, showing that genetic modifiers contribute to persistence. These results estimate the amount of natural epigenomic variation that can be lost after transient environmental exposures, and they reveal the complex genetic architecture of the DNA-encoded determinism of chromatin epi-polymorphisms. Our observations provide a basis for the development of population epigenetics.

  9. Zoomed EPI-DWI of the pancreas using two-dimensional spatially-selective radiofrequency excitation pulses.

    Directory of Open Access Journals (Sweden)

    Philipp Riffel

    Full Text Available BACKGROUND: Implementation of DWI in the abdomen is challenging due to artifacts, particularly those arising from differences in tissue susceptibility. Two-dimensional, spatially-selective radiofrequency (RF excitation pulses for single-shot echo-planar imaging (EPI combined with a reduction in the FOV in the phase-encoding direction (i.e. zooming leads to a decreased number of k-space acquisition lines, significantly shortening the EPI echo train and potentially susceptibility artifacts. PURPOSE: To assess the feasibility and image quality of a zoomed diffusion-weighted EPI (z-EPI sequence in MR imaging of the pancreas. The approach is compared to conventional single-shot EPI (c-EPI. MATERIAL AND METHODS: 23 patients who had undergone an MRI study of the abdomen were included in this retrospective study. Examinations were performed on a 3T whole-body MR system (Magnetom Skyra, Siemens equipped with a two-channel fully dynamic parallel transmit array (TimTX TrueShape, Siemens. The acquired sequences consisted of a conventional EPI DWI of the abdomen and a zoomed EPI DWI of the pancreas. For z-EPI, the standard sinc excitation was replaced with a two-dimensional spatially-selective RF pulse using an echo-planar transmit trajectory. Images were evaluated with regard to image blur, respiratory motion artifacts, diagnostic confidence, delineation of the pancreas, and overall scan preference. Additionally ADC values of the pancreatic head, body, and tail were calculated and compared between sequences. RESULTS: The pancreas was better delineated in every case (23/23 with z-EPI versus c-EPI. In every case (23/23, both readers preferred z-EPI overall to c-EPI. With z-EPI there was statistically significantly less image blur (p<0.0001 and respiratory motion artifact compared to c-EPI (p<0.0001. Diagnostic confidence was statistically significantly better with z-EPI (p<0.0001. No statistically significant differences in calculated ADC values were observed

  10. PREFACE: PAGES 1st Young Scientists Meeting (YSM) - 'Retrospective views on our planet's future'

    Science.gov (United States)

    Margrethe Basse, Ellen

    2010-03-01

    more recent pollution. The concept and format of the 1st PAGES YSM worked very well, and created a high degree of enthusiasm and stimulation among the participants (as is demonstrated by this special issue). The 2nd YSM is therefore firmly planned to take place in 2013, back-to-back with the 4th PAGES OSM. Crucial and gratefully acknowledged contributions to the success of the YSM were made by the numerous co-sponsors (see logos below), who provided the financial basis for the YSM and supported the attendance of many early-career researchers from various parts of the world. Furthermore, we cordially thank all reviewers for shaping this proceeding issue with their insightful and helpful reviews. Conference photograph

  11. EpiJen: a server for multistep T cell epitope prediction

    Directory of Open Access Journals (Sweden)

    Guan Pingping

    2006-03-01

    Full Text Available Abstract Background The main processing pathway for MHC class I ligands involves degradation of proteins by the proteasome, followed by transport of products by the transporter associated with antigen processing (TAP to the endoplasmic reticulum (ER, where peptides are bound by MHC class I molecules, and then presented on the cell surface by MHCs. The whole process is modeled here using an integrated approach, which we call EpiJen. EpiJen is based on quantitative matrices, derived by the additive method, and applied successively to select epitopes. EpiJen is available free online. Results To identify epitopes, a source protein is passed through four steps: proteasome cleavage, TAP transport, MHC binding and epitope selection. At each stage, different proportions of non-epitopes are eliminated. The final set of peptides represents no more than 5% of the whole protein sequence and will contain 85% of the true epitopes, as indicated by external validation. Compared to other integrated methods (NetCTL, WAPP and SMM, EpiJen performs best, predicting 61 of the 99 HIV epitopes used in this study. Conclusion EpiJen is a reliable multi-step algorithm for T cell epitope prediction, which belongs to the next generation of in silico T cell epitope identification methods. These methods aim to reduce subsequent experimental work by improving the success rate of epitope prediction.

  12. Distortion correction in EPI using an extended PSF method with a reversed phase gradient approach.

    Directory of Open Access Journals (Sweden)

    Myung-Ho In

    Full Text Available In echo-planar imaging (EPI, such as commonly used for functional MRI (fMRI and diffusion-tensor imaging (DTI, compressed distortion is a more difficult challenge than local stretching as spatial information can be lost in strongly compressed areas. In addition, the effects are more severe at ultra-high field (UHF such as 7T due to increased field inhomogeneity. To resolve this problem, two EPIs with opposite phase-encoding (PE polarity were acquired and combined after distortion correction. For distortion correction, a point spread function (PSF mapping method was chosen due to its high correction accuracy and extended to perform distortion correction of both EPIs with opposite PE polarity thus reducing the PSF reference scan time. Because the amount of spatial information differs between the opposite PE datasets, the method was further extended to incorporate a weighted combination of the two distortion-corrected images to maximize the spatial information content of a final corrected image. The correction accuracy of the proposed method was evaluated in distortion-corrected data using both forward and reverse phase-encoded PSF reference data and compared with the reversed gradient approaches suggested previously. Further we demonstrate that the extended PSF method with an improved weighted combination can recover local distortions and spatial information loss and be applied successfully not only to spin-echo EPI, but also to gradient-echo EPIs acquired with both PE directions to perform geometrically accurate image reconstruction.

  13. The relative roles of ANC and EPI in the continuous distribution of LLINs: a qualitative study in four countries.

    Science.gov (United States)

    Theiss-Nyland, Katherine; Koné, Diakalia; Karema, Corine; Ejersa, Waqo; Webster, Jayne; Lines, Jo

    2017-05-01

    The continuous distribution of long-lasting insecticidal nets (LLINs) for malaria prevention, through the antenatal care (ANC) and the Expanded Programme on Immunizations (EPI), is recommended by the WHO to improve and maintain LLIN coverage. Despite these recommendations, little is known about the relative strengths and weaknesses of the ANC and EPI-based LLIN distribution. This study aimed to explore and compare the roles of the ANC and EPI for LLIN distribution in four African countries. In a qualitative evaluation of continuous distribution through the ANC and EPI, semi-structured, individual and group interviews were conducted in Kenya, Malawi, Mali, and Rwanda. Respondents included national, sub-national, and facility-level health staff, and were selected to capture a range of roles related to malaria, ANC and EPI programmes. Policies, guidelines, and data collection tools were reviewed as a means of triangulation to assess the structure of LLIN distribution, and the methods of data collection and reporting for malaria, ANC and EPI programmes. In the four countries visited, distribution of LLINs was more effectively integrated through ANC than through EPI because of a) stronger linkages and involvement between malaria and reproductive health programmes, as compared to malaria and EPI, and b) more complete programme monitoring for ANC-based distribution, compared to EPI-based distribution. Opportunities for improving the distribution of LLINs through these channels exist, especially in the case of EPI. For both ANC and EPI, integrated distribution of LLINs has the potential to act as an incentive, improving the already strong coverage of both these essential services. The collection and reporting of data on LLINs distributed through the ANC and EPI can provide insight into the performance of LLIN distribution within these programmes. Greater attention to data collection and use, by both the global malaria community, and the integrated programmes, can improve

  14. PECULIAR FEATURES CONCERNING 1-ST-YEAR STUDENT ADAPTATION TO LIFE-ACTIVITY AT ENGINEERING HIGHER EDUCATIONAL INSTITUTION

    Directory of Open Access Journals (Sweden)

    V. A. Klimenko

    2008-01-01

    Full Text Available The paper contains an analysis of peculiar features concerning a 1-st-year student adaptation to new conditions of life-activity  on the basis of self-evaluation made by 212 persons.  In order to obtain the data a methodology for diagnostics of social and psychological adaptation developed by K.Rodgers and R.Diamond has been applied with the purpose to study such integral indices as adaptivity, emotional comfort, friendly attitude, internality, tolerance and domination symptom.

  15. Chondrosarcoma of right 1st rib presenting as neurogenic thoracic outlet syndrome; A 13th case report in world literature

    Directory of Open Access Journals (Sweden)

    Ravisagar Patel

    2016-07-01

    Full Text Available Thoracic outlet syndrome [TOS] caused by a tumor of the rib is rare and has been reported only 12 times in the literature over the past one and one-half centuries, with the majority of cases due to osteochondroma. We report a case of chondrosarcoma of right 1st rib causing neurogenic TOS that was resected via posterolateral thoracotomy and biopsy confirmed a grade I chondrosarcoma. In the treatment of chondrosarcoma, chemotherapy and radiotherapy are less effective, and appropriate surgery is needed.

  16. Lectures given at the 1st Session of the Centro Internazionale Matematico Estivo (C.I.M.E.)

    CERN Document Server

    1990-01-01

    The courses given at the 1st C.I.M.E. Summer School of 1988 dealt with the main areas on the borderline between applied logic and theoretical computer science. These courses are recorded here in five expository papers: S. Homer: The Isomorphism Conjecture and its Generalization.- A. Nerode: Some Lectures on Intuitionistic Logic.- R.A. Platek: Making Computers Safe for the World. An Introduction to Proofs of Programs. Part I. - G.E. Sacks: Prolog Programming.- A. Scedrov: A Guide to Polymorphic Types.

  17. CellMiner: a relational database and query tool for the NCI-60 cancer cell lines

    Directory of Open Access Journals (Sweden)

    Reinhold William C

    2009-06-01

    Full Text Available Abstract Background Advances in the high-throughput omic technologies have made it possible to profile cells in a large number of ways at the DNA, RNA, protein, chromosomal, functional, and pharmacological levels. A persistent problem is that some classes of molecular data are labeled with gene identifiers, others with transcript or protein identifiers, and still others with chromosomal locations. What has lagged behind is the ability to integrate the resulting data to uncover complex relationships and patterns. Those issues are reflected in full form by molecular profile data on the panel of 60 diverse human cancer cell lines (the NCI-60 used since 1990 by the U.S. National Cancer Institute to screen compounds for anticancer activity. To our knowledge, CellMiner is the first online database resource for integration of the diverse molecular types of NCI-60 and related meta data. Description CellMiner enables scientists to perform advanced querying of molecular information on NCI-60 (and additional types through a single web interface. CellMiner is a freely available tool that organizes and stores raw and normalized data that represent multiple types of molecular characterizations at the DNA, RNA, protein, and pharmacological levels. Annotations for each project, along with associated metadata on the samples and datasets, are stored in a MySQL database and linked to the molecular profile data. Data can be queried and downloaded along with comprehensive information on experimental and analytic methods for each data set. A Data Intersection tool allows selection of a list of genes (proteins in common between two or more data sets and outputs the data for those genes (proteins in the respective sets. In addition to its role as an integrative resource for the NCI-60, the CellMiner package also serves as a shell for incorporation of molecular profile data on other cell or tissue sample types. Conclusion CellMiner is a relational database tool for

  18. Fast, accurate and automatic ancient nucleosome and methylation maps with epiPALEOMIX

    DEFF Research Database (Denmark)

    Hanghøj, Kristian Ebbesen; Seguin-Orlando, Andaine; Schubert, Mikkel

    2016-01-01

    present epiPALEOMIX, an open-source and user-friendly pipeline that exploits post-mortem DNA degradation patterns to reconstruct ancient methylomes and nucleosome maps from shotgun and/or capture-enrichment data. Applying epiPALEOMIX to the sequence data underlying 35 ancient genomes including AMH, AH......, equids and aurochs, we investigate the temporal, geographical and preservation range of ancient epigenetic signatures. We first assess the quality of inferred ancient epigenetic signatures within well-characterized genomic regions. We find that tissue-specific methylation signatures can be obtained...... of CTCF binding regions can be used to help data authentication. Our work, including epiPALEOMIX, opens for further investigations of ancient epigenomes through time especially aimed at tracking possible epigenetic changes during major evolutionary, environmental, socioeconomic, and cultural shifts....

  19. Comparable Research of Energy and Ecology Parameters of 1st, 2nd and 3rd Generation Biofuels for Compression Ignition Engines

    National Research Council Canada - National Science Library

    Justas Zaglinskis

    2015-01-01

    .... Main attention focused on energy and environmental characteristics of diesel engine performance using 1st, 2nd and 3rd generation alcohol, fatty acid methyl and butyl esters blends with conventional diesel fuel (EN 590...

  20. Coal mining situation in the Federal Republic of Germany. The 1st quarter 2017; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Vierteljahr 2017

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2017-06-14

    The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2017. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

  1. Coal mining situation in the Federal Republic of Germany. The 1st quarter 2016; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Vierteljahr 2016

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-06-06

    The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2016. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

  2. A new modified CKD-EPI equation for Chinese patients with type 2 diabetes.

    Directory of Open Access Journals (Sweden)

    Xun Liu

    Full Text Available OBJECTIVE: To improve the performance of glomerular filtration rate (GFR estimating equation in Chinese type 2 diabetic patients by modification of the CKD-EPI equation. DESIGN AND PATIENTS: A total of 1196 subjects were enrolled. Measured GFR was calibrated to the dual plasma sample 99mTc-DTPA-GFR. GFRs estimated by the re-expressed 4-variable MDRD equation, the CKD-EPI equation and the Asian modified CKD-EPI equation were compared in 351 diabetic/non-diabetic pairs. And a new modified CKD-EPI equation was reconstructed in a total of 589 type 2 diabetic patients. RESULTS: In terms of both precision and accuracy, GFR estimating equations all achieved better results in the non-diabetic cohort comparing with those in the type 2 diabetic cohort (30% accuracy, P≤0.01 for all comparisons. In the validation data set, the new modified equation showed less bias (median difference, 2.3 ml/min/1.73 m2 for the new modified equation vs. ranged from -3.8 to -7.9 ml/min/1.73 m2 for the other 3 equations [P<0.001 for all comparisons], as was precision (IQR of the difference, 24.5 ml/min/1.73 m2 vs. ranged from 27.3 to 30.7 ml/min/1.73 m2, leading to a greater accuracy (30% accuracy, 71.4% vs. 55.2% for the re-expressed 4 variable MDRD equation and 61.0% for the Asian modified CKD-EPI equation [P = 0.001 and P = 0.02]. CONCLUSION: A new modified CKD-EPI equation for type 2 diabetic patients was developed and validated. The new modified equation improves the performance of GFR estimation.

  3. EpiPen epidemic: suggestions for rational prescribing in childhood food allergy.

    Science.gov (United States)

    Kemp, A S

    2003-07-01

    There has been a marked increase in community concerns of the risk of food induced anaphylaxis in children and a consequent increase in the provision of the self or carer injectable epinephrine (EpiPen) (CSL Ltd, Parkville, Victoria, Australia)). The Australian use of EpiPens in children under 10 years has increased by 300% over 5 years with a crude rate of EpiPen provision of 1 per 544 Australian children aged under 10 years. However, the risk of a fatal reaction to food, particularly in preschool children, is remote (in Australia, an estimated one fatality in 30 years in the under 5-year-old population and two deaths in 10 years in the entire child population). It is therefore important to provide a perspective on the risk of death from food induced anaphylactic to parents and carers in view of the anxiety generated on this issue. The indications for provision of an EpiPen to children are not well defined. Six risk factors, which can be considered in evaluating the risk of a life-threatening reaction (age over 5 years; a history of respiratory tract involvement with the initial or subsequent reactions; a history of asthma requiring preventer medication; peanut or tree nut sensitivity; reactions induced by traces or small amounts of allergen; a strongly positive skin prick test) are proposed. It is suggested that the greater the number that are positive, the lower the threshold for provision of an EpiPen. In addition, instruction in EpiPen administration and the provision of both a clear and simple anaphylaxis action plan and a rational perspective on the remote risk of death is just as important as the provision of the device itself.

  4. Mapping three-dimensional oil distribution with π-EPI MRI measurements at low magnetic field

    Science.gov (United States)

    Li, Ming; Xiao, Dan; Romero-Zerón, Laura; Marica, Florea; MacMillan, Bryce; Balcom, Bruce J.

    2016-08-01

    Magnetic resonance imaging (MRI) is a robust tool to image oil saturation distribution in rock cores during oil displacement processes. However, a lengthy measurement time for 3D measurements at low magnetic field can hinder monitoring the displacement. 1D and 2D MRI measurements are instead often undertaken to monitor the oil displacement since they are faster. However, 1D and 2D images may not completely reflect the oil distribution in heterogeneous rock cores. In this work, a high-speed 3D MRI technique, π Echo Planar Imaging (π-EPI), was employed at 0.2 T to monitor oil displacement. Centric scan interleaved sampling with view sharing in k-t space was employed to improve the temporal resolution of the π-EPI measurements. A D2O brine was employed to distinguish the hydrocarbon and water phases. A relatively homogenous glass bead pack and a heterogeneous Spynie core plug were employed to show different oil displacement behaviors. High quality 3D images were acquired with π-EPI MRI measurements. Fluid quantification with π-EPI compared favorably with FID, CPMG, 1D-DHK-SPRITE, 3D Fast Spin Echo (FSE) and 3D Conical SPRITE measurements. π-EPI greatly reduced the gradient duty cycle and improved sensitivity, compared to FSE and Conical SPRITE measurements, enabling dynamic monitoring of oil displacement processes. For core plug samples with sufficiently long lived T2, T2∗, π-EPI is an ideal method for rapid 3D saturation imaging.

  5. Body conceptions of 1st and 8th semesters students from two Goiás Universities.

    Directory of Open Access Journals (Sweden)

    Terita Michele da Silva Ferreira

    2013-12-01

    Full Text Available To understand physical education student’s body conceptions is important to analyze how their formation and social determinations is influencing their way of thinking, which can impact on theirs posterior professional intervention. This way, the scientific question of this text is to know if: “Does exist differences between body conceptions of academic students of 1st and 8th period of two graduation courses?”. The general objective is to identify and compare the body conceptions of 1st and 8th period of physical education graduation courses (licensure of two teaching institutions of Goiás. This descriptive research with qualitative analyzes was made by a questionnaire specially elaborated to this research that it was applied with 143 students of Physical Education Licensure of the two Universities. The results show that the body conceptions are near the hegemonic paradigms, directed to an understanding of instrumental body, showing that is necessary a better discussion in the academic environment.

  6. The optimization study of Bonner sphere in the epi-thermal neutron irradiation field for BNCT.

    Science.gov (United States)

    Ueda, H; Tanaka, H; Maruhashi, A; Ono, K; Sakurai, Y

    2011-12-01

    The optimization study on the Bonner sphere in the epi-thermal neutron irradiation field for BNCT was done for the moderator material, moderator size, and activation foils as a neutron detector in the sphere. The saturated activity for the activation foil was obtained from the calculated response, and the effective energy range for each Bonner sphere was determined from the saturated activity. We can see that boric acid solution moderator is suitable for the spectrum measurement of a epi-thermal neutron irradiation field.

  7. Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa visiting ALICE experiment on 1st November 2007 with CERN Director-General R. Aymar and Adviser J.-P. Revol. Thursday, 1st and Friday, 2nd November 2007

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa visiting ALICE experiment on 1st November 2007 with CERN Director-General R. Aymar and Adviser J.-P. Revol. Thursday, 1st and Friday, 2nd November 2007

  8. Global microRNA analysis of the NCI-60 cancer cell panel

    DEFF Research Database (Denmark)

    Søkilde, Rolf; Kaczkowski, Bogumil; Podolska, Agnieszka

    2011-01-01

    MicroRNAs (miRNA) are a group of short noncoding RNAs that regulate gene expression at the posttranscriptional level. They are involved in many biological processes, including development, differentiation, apoptosis, and carcinogenesis. Because miRNAs may play a role in the initiation...... and progression of cancer, they comprise a novel class of promising diagnostic and prognostic molecular markers and potential drug targets. By applying an LNA-enhanced microarray platform, we studied the expression profiles of 955 miRNAs in the NCI-60 cancer cell lines and identified tissue- and cell......-type-specific miRNA patterns by unsupervised hierarchical clustering and statistical analysis. A comparison of our data to three previously published miRNA expression studies on the NCI-60 panel showed a remarkably high correlation between the different technical platforms. In addition, the current work...

  9. Methodology of Establishing and Identifying NCI-H2228/Crizotinib-resistant Cell Lines In Vitro

    Directory of Open Access Journals (Sweden)

    Di WU

    2015-06-01

    Full Text Available Background and objective The mechanisms of small molecule targeting drug resistance and ways to overcome resistance are now both urgent need to improve the clinical efficacy. This study aimed to investigate the feasibility of using different methods to establish the crizotinib-resistant non-small cell lung cancer NCI-H2228/Crizotinib cell lines and to clarify the mechanisms of resistance to small molecule targeting drug, thus providing experimental and theoretical bases for further studies to overcome the mechanisms of Crizotinib resistance. Methods The study utilized stepwise increase of drug concentrations and chemical mutagen to induce Crizotinib-resistant NCI-H2228 cells. The drug 50% inhibitory concentration (IC50 values of parental and resistant cells and the population doubling time were determined by MTT assay. The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK expression was evaluated by RT-PCR and Western blot. Full-length sequencing method was used to compare the EML4-ALK genes in the parent and drug-resistant cells and analyze the mechanisms of drug resistance. Results The method of gradually increasing drug concentration to induce Crizotinib-resistant NCI-H2228 cells was time-consuming because the cell growth recovery was extremely slow. Thus, this method was considered invalid. However, chemical mutagen ENU can effectively induce NCI-H2228 cells resistant to crizotinib in a short time [IC50]= (3.810±1.100 μmol/L, P=0.002,9 vs parental cells]. Furthermore, the gene mutation frequency of EML4-ALK in the resistant cells was significantly higher than that in the parent cells. Conclusion Chemical mutagen-induced cell resistance was easily operated and had effectively shortened the experimental process. Preliminary technical methods and experimental evidence for in-depth study of drug resistance mechanisms and approaches to overcome the targeted drug resistance were also provided.

  10. NCI Launches Proteomics Assay Portal | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    In a paper recently published by the journal Nature Methods, Investigators from the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (NCI-CPTAC) announced the launch of a proteomics Assay Portal for multiple reaction monitoring-mass spectrometry (MRM-MS) assays.  This community web-based repository for well-characterized quantitative proteomic assays currently consists of 456 unique peptide assays to 282 unique proteins and ser

  11. CellMiner Companion: an interactive web application to explore CellMiner NCI-60 data.

    Science.gov (United States)

    Wang, Sufang; Gribskov, Michael; Hazbun, Tony R; Pascuzzi, Pete E

    2016-08-01

    The NCI-60 human tumor cell line panel is an invaluable resource for cancer researchers, providing drug sensitivity, molecular and phenotypic data for a range of cancer types. CellMiner is a web resource that provides tools for the acquisition and analysis of quality-controlled NCI-60 data. CellMiner supports queries of up to 150 drugs or genes, but the output is an Excel file for each drug or gene. This output format makes it difficult for researchers to explore the data from large queries. CellMiner Companion is a web application that facilitates the exploration and visualization of output from CellMiner, further increasing the accessibility of NCI-60 data. The web application is freely accessible at https://pul-bioinformatics.shinyapps.io/CellMinerCompanion The R source code can be downloaded at https://github.com/pepascuzzi/CellMinerCompanion.git ppascuzz@purdue.edu Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  12. Computational Challenges and Collaborative Projects in the NCI Quantitative Imaging Network.

    Science.gov (United States)

    Farahani, Keyvan; Kalpathy-Cramer, Jayashree; Chenevert, Thomas L; Rubin, Daniel L; Sunderland, John J; Nordstrom, Robert J; Buatti, John; Hylton, Nola

    2016-12-01

    The Quantitative Imaging Network (QIN) of the National Cancer Institute (NCI) conducts research in development and validation of imaging tools and methods for predicting and evaluating clinical response to cancer therapy. Members of the network are involved in examining various imaging and image assessment parameters through network-wide cooperative projects. To more effectively use the cooperative power of the network in conducting computational challenges in benchmarking of tools and methods and collaborative projects in analytical assessment of imaging technologies, the QIN Challenge Task Force has developed policies and procedures to enhance the value of these activities by developing guidelines and leveraging NCI resources to help their administration and manage dissemination of results. Challenges and Collaborative Projects (CCPs) are further divided into technical and clinical CCPs. As the first NCI network to engage in CCPs, we anticipate a variety of CCPs to be conducted by QIN teams in the coming years. These will be aimed to benchmark advanced software tools for clinical decision support, explore new imaging biomarkers for therapeutic assessment, and establish consensus on a range of methods and protocols in support of the use of quantitative imaging to predict and assess response to cancer therapy.

  13. Schools as potential vaccination venue for vaccines outside regular EPI schedule: results from a school census in Pakistan

    NARCIS (Netherlands)

    Soofi, S.B.; Haq, I.U.; Khan, M.I.; Siddiqui, M.B.; Mirani, M.; Tahir, R.; Hussain, I.; Puri, M.K.; Suhag, Z.H.; Khowaja, A.R.; Lasi, A.R.; Clemens, J.D.; Favorov, M.; Ochiai, R.L.; Bhutta, Z.A.

    2012-01-01

    BACKGROUND: Vaccines are the most effective public health intervention. Expanded Program on Immunization (EPI) provides routine vaccination in developing countries. However, vaccines that cannot be given in EPI schedule such as typhoid fever vaccine need alternative venues. In areas where school

  14. Schools as potential vaccination venue for vaccines outside regular EPI schedule: results from a school census in Pakistan

    NARCIS (Netherlands)

    Soofi, S.B.; Haq, I.U.; Khan, M.I.; Siddiqui, M.B.; Mirani, M.; Tahir, R.; Hussain, I.; Puri, M.K.; Suhag, Z.H.; Khowaja, A.R.; Lasi, A.R.; Clemens, J.D.; Favorov, M.; Ochiai, R.L.; Bhutta, Z.A.

    2012-01-01

    BACKGROUND: Vaccines are the most effective public health intervention. Expanded Program on Immunization (EPI) provides routine vaccination in developing countries. However, vaccines that cannot be given in EPI schedule such as typhoid fever vaccine need alternative venues. In areas where school enr

  15. Impact of volcanic eruptions on the climate of the 1st millennium AD in a comprehensive climate simulation

    Science.gov (United States)

    Wagner, Sebastian; Zorita, Eduardo

    2015-04-01

    The climate of the 1st millennium AD shows some remarkable differences compared to the last millennium concerning variation in external forcings. Together with an orbitally induced increased solar insolation during the northern hemisphere summer season and a general lack of strong solar minima, the frequency and intensity of large tropical and extratropical eruptions is decreased. Here we present results of a new climate simulation carried out with the comprehensive Earth System Model MPI-ESM-P forced with variations in orbital, solar, volcanic and greenhouse gas variations and land use changes for the last 2,100 years. The atmospheric model has a horizontal resolution of T63 (approx. 125x125 km) and therefore also allows investigations of regional-to-continental scale climatic phenomena. The volcanic forcing was reconstructed based on a publication by Sigl et al. (2013) using the sulfate records of the NEEM and WAIS ice cores. To obtain information on the aerosol optical depth (AOD) these sulfate records were scaled to an established reconstruction from Crowley and Unterman (2010), which is also a standard forcing in the framework of CMIP5/PMIP3. A comparison between the newly created data set with the Crowley and Unterman dataset reveals that the new reconstruction shows in general weaker intensities, especially of the large tropical outbreaks and fewer northern hemispheric small-to-medium scale eruptions. However, the general pattern in the overlapping period is similar. A hypothesis that can be tested with the simulation is whether the reduced volcanic intensity of the 1st millennium AD contributed to the elevated temperature levels over Europe, evident within a new proxy-based reconstruction. On the other hand, the few but large volcanic eruptions, e.g. the 528 AD event, also induced negative decadal-scale temperature anomalies. Another interesting result of the simulation relates to the 79 AD eruption of the Vesuvius, which caused the collapse of the city of

  16. Electronic Principles Inventory Sheppard Technical Training Center, AFPT 90-EPI-485.

    Science.gov (United States)

    1984-06-01

    based job inventory which identifies the range of electronics principles personnel must understand to perform any electronics-oriented job. Training...managers can use EPI data in conjunction with OSR data to determine precisely what specialists do and what electronics principles they employ on the job

  17. Northienamycin and 8-epi-thienamycin, new carbapenems from Streptomyces cattleya.

    Science.gov (United States)

    Wilson, K E; Kempf, A J; Liesch, J M; Arison, B H

    1983-09-01

    Two new carbapenem antibiotics, northienamycin and 8-epi-thienamycin have been isolated from culture broth of Streptomyces cattleya grown under conditions for thienamycin production. The isolation, structure elucidation and in vitro antibacterial spectra of the new carbapenems are reported. In addition, comparison of the in vitro potency of the corresponding formamidine derivatives to that of MK787 is presented.

  18. Roles of epi-anecic taxa of earthworms in the organic matter recycling

    Science.gov (United States)

    Hoeffner, Kevin; Monard, Cécile; Santonja, Mathieu; Pérès, Guénola; Cluzeau, Daniel

    2017-04-01

    Given their impact on soil functioning and their interactions with soil organisms, earthworms contribute to the recycling of organic matter and participate significantly in the numerous ecosystem services provided by soils. Most studies on the role of earthworms in organic matter recycling were conducted at the level of the four functional groups (epigeic, epi-anecic, anecic strict and endogeic), but their effects at taxa level remain largely unknown. Still, within a functional group, anatomic and physiologic earthworm taxa traits are different, which should impact organic matter recycling. This study aims at determining, under controlled conditions, epi-anecic taxa differences in (i) leaf litter mass loss, (ii) assimilation and (iii) impact on microorganisms communities implied in organic matter degradation. In seperate microcosms, we chose 4 epi anecic taxa (Lumbricus rubellus, Lumbricus festivus, Lumbricus centralis and Lumbricus terrestris). Each taxon was exposed separately to leaves of three different plants (Holcus lanatus, Lolium perenne and Corylus avellana). In the same microcosm, leaves of each plant was both placed on the surface and buried 10cm deep. The experiment lasted 10 days for half of the samples and 20 days for the second half. Microorganisms communities were analysed using TRFLP in each earthworm taxon burrow walls at 20 days. We observed differences between epi-anecic taxa depending on species of plant and the duration of the experiment. Results are discussed taking into account physical and chemical properties of these 3 trophic resources (e.g. C/N ratio, phenolic compounds, percentage of lignin and cellulose...).

  19. The EpiSLI Database: A Publicly Available Database on Speech and Language

    Science.gov (United States)

    Tomblin, J. Bruce

    2010-01-01

    Purpose: This article describes a database that was created in the process of conducting a large-scale epidemiologic study of specific language impairment (SLI). As such, this database will be referred to as the EpiSLI database. Children with SLI have unexpected and unexplained difficulties learning and using spoken language. Although there is no…

  20. EPI Nyquist ghost and geometric distortion correction by two-frame phase labeling.

    Science.gov (United States)

    Xie, Victor B; Lyu, Mengye; Wu, Ed X

    2017-05-01

    To develop a new Nyquist ghost and geometric distortion correction method in echo planar imaging (EPI) using parallel imaging. Two frames of EPI data are acquired with normal and phase-labeled sequence. The phase label is applied by modifying the PE prephase gradient to shift the central echo by one echo spacing. GRAPPA weights are trained from both frames and used to reconstruct images from positive or negative echoes in each frame to remove Nyquist ghost. Geometric distortion is then corrected by the B0 field map generated from the phase difference between positive and negative echo images. Phantom and in vivo experiments at 7 Tesla (T) and 3T were performed to evaluate the proposed method. Nyquist ghost was greatly reduced in all images even under oblique imaging and poor eddy current conditions, yielding significant improvements over the existing reference scan and image entropy minimization based methods. Image geometries were fully restored after distortion correction. Phantom results indicated that the signal-to-noise ratio efficiency was largely preserved while fMRI results showed no apparent degradation of temporal resolution. The proposed method provides robust correction of both Nyquist ghost and geometric distortion in EPI, and it is particularly suitable for dynamic EPI applications. Magn Reson Med 77:1749-1761, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  1. [EpiInfo as a research and teaching tool in epidemiology and statistics: strengths and weaknesses].

    Science.gov (United States)

    Mannocci, Alice; Bontempi, Claudio; Giraldi, Guglielmo; Chiaradia, Giacomina; de Waure, Chiara; Sferrazza, Antonella; Ricciardi, Walter; Boccia, Antonio; La Torre, Giuseppe

    2012-01-01

    EpiInfo is a free software developed in 1988 by the Centers for Disease Control and Prevention (CDC) in Atlanta to facilitate field epidemiological investigations and statistical analysis. The aim of this study was to assess whether the software represents, in the Italian biomedical field, an effective analytical research tool and a practical and simple epidemiology and biostatistics teaching tool. A questionnaire consisting of 20 multiple-choice and open questions was administered to 300 healthcare workers, including doctors, biologists, nurses, medical students and interns, at the end of a CME course in epidemiology and biostatistics. Sixty-four percent of participants were aged between 26 and 45 years, 52% were women and 73% were unmarried. Results show that women are more likely to utilize EpiInfo in their research activities with respect to men (p = 0.023), as are individuals aged 26-45 years with respect to the older and younger age groups (p = 0.023) and unmarried participants with respect to those married (p = 0.010). Thirty-one percent of respondents consider EpiInfo to be more than adequate for analysis of their research data and 52% consider it to be sufficiently so. The inclusion of an EpiInfo course in statistics and epidemiology modules facilitates the understanding of theoretical concepts and allows researchers to more easily perform some of the clinical/epidemiological research activities.

  2. The effect of the diterpene 5-epi-icetexone on the cell cycle of Trypanosoma cruzi.

    NARCIS (Netherlands)

    Lozano, E.; Barrera, P.; Tonn, C.; Nieto, M.; Sartor, T.; Sosa, M.A.

    2012-01-01

    Numerous natural compounds have been used against Trypanosoma cruzi, the causative agent of Chagas' disease. Here, we studied the effect of the diterpene 5-epi-icetexone on growth and morphology of parasites synchronized with hydroxyurea, at different periods of time after removal of the nucleotide.

  3. A Facile Synthesis of Spin Labeled 4'-Epi-N-Trifuoroactyldaunomycin Derivatives

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The spin labeled 4'-Epi-N-trifuoroacetyldaunomycin derivatives 6-7 were conveniently synthesized from daunomycin in middle yield. The key steps were the protection of compd. 5 at 9-position and nucleophilic displacement of 5 with R.COOH and DBU at room temperature.

  4. The effect of the diterpene 5-epi-icetexone on the cell cycle of Trypanosoma cruzi.

    NARCIS (Netherlands)

    Lozano, E.; Barrera, P.; Tonn, C.; Nieto, M.; Sartor, T.; Sosa, M.A.

    2012-01-01

    Numerous natural compounds have been used against Trypanosoma cruzi, the causative agent of Chagas' disease. Here, we studied the effect of the diterpene 5-epi-icetexone on growth and morphology of parasites synchronized with hydroxyurea, at different periods of time after removal of the nucleotide.

  5. Preparation of 4- and 6-desphenyl analogues of (-)-clausenamide and alternative synthesis of (+)-epi-clausenamide

    Institute of Scientific and Technical Information of China (English)

    Jian Jun Xue; Yu Mei Zhou; Xiao Ming Yu

    2011-01-01

    4- and 6-desphenyl analogues of (-)-clausenamide, 6 and 7, were prepared in optical active form from commercially available D-pyroglutamic acid and the known racemic pyrrolidinone 13, respectively. In order to confirm the absolute stereochemistry of (+)-and (-)-7, intermediate 19b was transferred into the (+)-epi-clausenamide 8.

  6. Rab27A regulates exosome secretion from lung adenocarcinoma cells A549: involvement of EPI64.

    Science.gov (United States)

    Li, Wenhai; Hu, Yunsheng; Jiang, Tao; Han, Yong; Han, Guoliang; Chen, Jiakuan; Li, Xiaofei

    2014-11-01

    Exosomes are small membrane vesicles secreted into the extracellular compartment by exocytosis. The unique composition of exosomes can be transported to other cells which allow cells to exert biological functions at distant sites. However, in lung cancer, the regulation of exosome secretion was poorly understood. In this study, we employed human lung adenocarcinoma A549 cells to determine the exosome secretion and involved regulation mechanism. We found that Rab27A was expressed in A549 cells and the reduction of Rab27A by Rab27A-specific shRNA could significantly decrease the secretion of exosome by A549 cells. EPI64, a candidate GAP that is specific for Rab27, was also detected in A549 cells. By pull-down assay, we found that EPI64 participated in the exosome secretion of A549 cells by acting as a specific GAP for Rab27A, not Rab27B. Overexpression of EPI64 enhanced exosome secretion. Taken together, in A549 cells, EPI64 could regulate the exosome secretion by functioning as a GAP specific for Rab27A.

  7. Wordlists of Delta Edo: Epie, Engenni, Degema. Occasional Publication No. 8.

    Science.gov (United States)

    Thomas, Elaine; Williamson, Kay

    A word list is provided for the three Delta Edo languages, Epie, Engenni, and Degema, which are spoken in the eastern part of the Niger Delta. A general map of the location of the Delta Edo languages is provided, and background information on the recent discovery of the derivation of these languages is given by way of introduction. The…

  8. Comparison of dB/dt between EPI and spin-echo pulse sequences

    Energy Technology Data Exchange (ETDEWEB)

    Ogura, Akio [Kyoto City Hospital (Japan); Hongoh, Takaharu; Inoue, Hiroshi; Yamazaki, Masaru; Higashida, Mitsuharu

    2001-04-01

    In MR imaging, the time-varying magnetic field associated with gradients induces electric fields in the human body and may stimulate nerves and even the heart. The time rate of change in gradient magnetic fields on echo planar imaging (EPI) needs to exceed 20 mT/ms. EPI has recently become more widely used in the clinical field, and the protection of patient safety during MR scans has become an issue. However dB/dt as an index of the time-varying magnetic field is not displayed on the operating monitor. Therefore dB/dt of various scan techniques was measured using a search coil and storage oscilloscope, according to the IEC standard method. The results demonstrated that dB/dt of EPI, spin-echo, and field-echo techniques are much the same. Thus, the possibility of a risk to health resulting from EPI scanning is the same as that for other scanning techniques that use a high-performance MRI system. Therefore, even with spin-echo scanning, it is necessary to consider biological change in patients. (author)

  9. Beyond Ribosomal Binding: The Increased Polarity and Aberrant Molecular Interactions of 3-epi-deoxynivalenol

    Science.gov (United States)

    Hassan, Yousef I.; Zhu, Honghui; Zhu, Yan; Zhou, Ting

    2016-01-01

    Deoxynivalenol (DON) is a secondary fungal metabolite and contaminant mycotoxin that is widely detected in wheat and corn products cultivated around the world. Bio-remediation methods have been extensively studied in the past two decades and promising ways to reduce DON-associated toxicities have been reported. Bacterial epimerization of DON at the C3 carbon was recently reported to induce a significant loss in the bio-toxicity of the resulting stereoisomer (3-epi-DON) in comparison to the parental compound, DON. In an earlier study, we confirmed the diminished bio-potency of 3-epi-DON using different mammalian cell lines and mouse models and mechanistically attributed it to the reduced binding of 3-epi-DON within the ribosomal peptidyl transferase center (PTC). In the current study and by inspecting the chromatographic behavior of 3-epi-DON and its molecular interactions with a well-characterized enzyme, Fusarium graminearum Tri101 acetyltransferase, we provide the evidence that the C3 carbon epimerization of DON influences its molecular interactions beyond the abrogated PTC binding. PMID:27618101

  10. Levels of innate immune factors in preterm and term mothers' breast milk during the 1st month postpartum.

    Science.gov (United States)

    Trend, Stephanie; Strunk, Tobias; Lloyd, Megan L; Kok, Chooi Heen; Metcalfe, Jessica; Geddes, Donna T; Lai, Ching Tat; Richmond, Peter; Doherty, Dorota A; Simmer, Karen; Currie, Andrew

    2016-04-14

    There is a paucity of data on the effect of preterm birth on the immunological composition of breast milk throughout the different stages of lactation. We aimed to characterise the effects of preterm birth on the levels of immune factors in milk during the 1st month postpartum, to determine whether preterm milk is deficient in antimicrobial factors. Colostrum (days 2-5 postpartum), transitional milk (days 8-12) and mature milk (days 26-30) were collected from mothers of extremely preterm (preterm (28-preterm (32-preterm mothers had significantly higher concentrations of HBD1 and TGF-β2 in colostrum than term mothers did. After controlling for other variables in regression analyses, preterm birth was associated with higher concentrations of HBD1, LZ and sCD14 in milk samples. In conclusion, preterm breast milk contains significantly higher concentrations of some immune proteins than term breast milk.

  11. Plasma properties from the multi-wavelength analysis of the November 1st 2003 CME/shock event

    CERN Document Server

    Benna, Carlo; Giordano, Silvio; Gioannini, Lorenzo

    2012-01-01

    The analysis of the spectral properties and dynamic evolution of a CME/shock event observed on November 1st 2003 in white-light by the LASCO coronagraph and in the ultraviolet by the UVCS instrument operating aboard SOHO, has been performed to compute the properties of some important plasma parameters in the middle corona below about 2 solar radii. Simultaneous observations obtained with the MLSO/Mk4 white-light coronagraph, providing both the early evolution of the CME expansion in the corona and the pre-shock electron density profile along the CME front, were also used to study this event. By combining the above information with the analysis of the metric type II radio emission detected by ground-based radio spectrographs, we finally derive estimates of the values of the local Alfv\\'en speed and magnetic field strength in the solar corona.

  12. Proceedings of the 1st International Operational Modal Analysis Conference, April 26-27, 2005, Copenhagen, Denmark

    DEFF Research Database (Denmark)

    /S and the Department of Building Technology and Structural Engineering at Aalborg University. It is the first conference ever to focus solely on experimental modal analysis for cases where only the responses are measured. It was decided to hold the conference to generate interest in operational modal analysis (also......These proceedings contain approximately 100 papers presented at the 1st International Operational Modal Conference, Copenhagen, Denmark, April 26 - 27, 2005. The conference is jointly organised by Structural Vibration Systems (SVS), Aalborg, Brüel & Kjær Sound and Vibration Measurement A...... known as ambient modal analysis, output-only modal analysis and natural input modal analysis) which has been around since the beginning of the development of traditional modal analysis in the early seventies. From the beginning, these techniques proved to have several advantages, due to less testing...

  13. LARGE BOULDERS ALONG THE RABAT COAST (MOROCCO; POSSIBLE EMPLACEMENT BY THE NOVEMBER, 1st, 1755 A.D. TSUNAMI

    Directory of Open Access Journals (Sweden)

    Nadia Mhammdi, Fida Medina

    2008-01-01

    Full Text Available The rocky coastline south of Rabat (Morocco shows a large number of boulders lying upon the lithified dune system. The boulders, of 4-100 tons, may be single, in imbricated sets, or forming clusters and ridges. Several of the boulders were lifted and overturned, thus showing pool apertures downwards. Transport distance is generally decametric because of the surface roughness, but it can reach 300 m in flat areas. All boulders have been detached from their initial position at the fractured front of the active cliff. Quantification with the help wave hydrodynamics and rock displacement mechanics shows that dislodgement and transport of these boulders were accomplished rather by tsunami than by storm waves. Although no dating was attempted, post- emplacement bio-erosion by littorinids and the absence of any erosional features below the boulders suggests that they were emplaced during the 1st November 1755 AD Lisbon tsunami.

  14. 1st or 2nd generation bioethanol-impacts of technology integration & on feed production and land use

    DEFF Research Database (Denmark)

    Bentsen, Niclas Scott; Felby, Claus

    2009-01-01

    with the poorest bio synthesis efficiency and as such the area demand for their production is relatively high. Preservation of the proteins in the biomass such as in feed by-products from bioethanol production is of paramount importance in developing sustainable utilisation of biomass in the energy sector......."1st or 2nd generation bioethanol-impacts of technology integration & on feed production and land use" Liquid bio fuels are perceived as a means of mitigating CO2 emissions from transport and thus climate change, but much concern has been raised to the energy consumption from refining biomass...... to liquid fuels. Integrating technologies such that waste stream can be used will reduce energy consumption in the production of bioethanol from wheat. We show that the integration of bio refining and combined heat an power generation reduces process energy requirements with 30-40 % and makes bioethanol...

  15. Report about the 1st De Frutos - Universidad Miguel Hernández Judo Scientific Congress with Training Camp

    Directory of Open Access Journals (Sweden)

    Juan José Pulido González

    2013-12-01

    Full Text Available The current report resumes the 1st De Frutos-Universidad Miguel Hernández Judo Scientific Congress, held in San Juan de Alicante (Spain from the 27th to the 30th of June in 2013. Three plenary sessions in classroom, 12 oral communications, a round – table, 2 theoretical – practical workshops on tatami, and 3 randori sessions were developed. This congress was a new event where judo personalities at the international level as well as scientists from the whole Spanish geography interested in this field assisted. The event complied the aim to approach the science to judo professionals and vice versa. A total amount of 112 participants were in the congress.

  16. Role of EPI in diagnosing cavernous hemangioma and small HCC : comparison with fast T2-weighted MR Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Suk; Lee, Jun Woo; Kim, Chang Won; Jung, Hyun Woo; Choi, Sang Yoel; Lee, Suck Hong; Kim, Byung Soo [Pusan National Univeraty Hospital, Pusan (Korea, Republic of)

    1998-05-01

    The purpose of this study is to compare single-shot echo-planar MR imaging (EPI) with breath-hold fast T2-weighted imaging (HASTE or Turbo spin-echo T2WI) for evaluation of the role of EPI in distinguishing small hepatocellular carcinoma from cavernous hemangioma. We retrospectively evaluated MR images of 35 patients (21 cases of small HCC and 14 cases of cavernous hemangioma). EPI and breath-hold fast T2WI images were obtained and compared on the basis of lesion detection sensitivity, lesion-to-liver signal intensity ratio (SIR), contrast ratio (CR), and lesion-to-liver contrast to noise ratio (CNR). For the detection of small HCC, the sensitivity of EPI and breath-hold fast T2WI were equal in 14 of 21 cases (71.4%). The detection sensitivity of cavernous hemangioma with EPI and breath-hold fast T2WI was 100 % (14/14). Mean SIR on breath-hold fast T2WI was 2.02 {+-} 0.45 for small HCC and 3.65 {+-} 0.97 for cavernous hemangioma; on EPI, the corresponding figures were 2.91 {+-} 0.57 for cavernous hemangioma; On EPI, the figures obtained were 2.27 {+-} 0.52 and 6.26 {+-} 2.19, respectively. Mean CNR on breath-hold fast T2WI was 14.24 {+-} 4.098 for small HCC and 50.28 {+-} 10.96 for cavernous hemangioma, while on EPI, the corresponding figures were 13.84 {+-} 3.02 and 45.44 {+-} 11.21. In detecting focal hepatic mass, the sensitivity of EPI and breath-hold fast T2WI are comparable for the diagnosis of small HCC and cavernous hemangioma, EPI can provided additional information. (author). 20 refs., 2 tabs., 4 figs.

  17. Epi-LASIK e PRK: um ano de estudo comparativo em olhos contralaterais

    Directory of Open Access Journals (Sweden)

    Francisco Penteado Crestana

    2013-08-01

    Full Text Available OBJETIVO: Comparar as técnicas de PRK e Epi-LASIK com relação à recuperação visual e sintomatologia pós-operatória. MÉTODOS: Série de casos intervencionista que incluiu 38 olhos de 19 pacientes com miopia até 5DE e astigmatismo até 1DC. Foram selecionados pacientes com erros refracionais semelhantes nos dois olhos, realizando-se, no mesmo tempo cirúrgico, PRK em um olho e Epi-LASIK no olho contralateral. Os pacientes foram acompanhados por um ano, avaliando-se a eficácia refracional e grau de desconforto pós-operatório. RESULTADOS: Durante as primeiras 12 horas, 79,9% dos pacientes (p=0,0003 referiram dor mais intensa no olho operado com a técnica Epi-LASIK. Após 24 horas, 63,2% dos pacientes (p=0,012 ainda referiam mais dor neste olho e apenas 10,5% no olho contralateral. A acuidade visual não corrigida foi melhor nos olhos do grupo PRK no primeiro dia (p=0,034. Nos demais dias não houve diferença significativa entre os grupos. Houveopacidade corneana grau 0,5 (Fantes em três olhos do grupo PRK e em dois no grupo Epi-LASIK. CONCLUSÃO: Ambos os grupos apresentaram resultado visual refracional satisfatório, porém o grupo Epi-LASIK apresentou maior desconforto no pós-operatório imediato.

  18. [Effectiveness of teaching gerontology and geriatrics in students of the 1st Faculty of Medicine, Charles University in Prague].

    Science.gov (United States)

    Mádlová, P; Neuwirth, J; Topinková, E

    2006-01-01

    Increasing number of seniors in the society requires more university-degree educated professionals--health care professionals, social care workers and managers with basic exposure to and knowledge of gerontology and geriatrics. The aim of our paper was to evaluate the effectiveness of undergraduate training of gerontology and geriatrics among students of the 1st Faculty of Medicine, Charles University in Prague. To get information about knowledge of medical students and students of ergotherapy and physiotherapy and about their attitudes towards senior citizens we conducted a survey using two anonymous questionnaires prepared in our department and piloted earlier. The survey ran during the academic year 2004/2005. Students completed identical questionnaires twice, first time before the start of the clinical rotation and second time after the training end (n=134). Evaluation of knowledge and attitudes confirmed that one to two weeks clinical rotation at Department of Geriatrics was effective and increased knowledge of students in the topic trained. The percentage of correct answers in all three evaluated training programmes increased after the completion of the clinical rotation and reached 83% and more. From 134 participating students, 54.5 % appreciated life experience and wisdom of seniors they met, 98.4 % of students were satisfied with the training programme and 67.2 % of students reported that after training they changed their attitude towards senior population. Our survey confirmed that clinical training in geriatric medicine at 1st Faculty of Medicine, Charles University in Prague, prepared in agreement with current European recommendations is sufficiently effective and well accepted by the students. Therefore we recommend introduction of formal geriatric training for students in all medical faculties in the Czech Republic.

  19. EpiTracer - an algorithm for identifying epicenters in condition-specific biological networks.

    Science.gov (United States)

    Sambaturu, Narmada; Mishra, Madhulika; Chandra, Nagasuma

    2016-08-18

    In biological systems, diseases are caused by small perturbations in a complex network of interactions between proteins. Perturbations typically affect only a small number of proteins, which go on to disturb a larger part of the network. To counteract this, a stress-response is launched, resulting in a complex pattern of variations in the cell. Identifying the key players involved in either spreading the perturbation or responding to it can give us important insights. We develop an algorithm, EpiTracer, which identifies the key proteins, or epicenters, from which a large number of changes in the protein-protein interaction (PPI) network ripple out. We propose a new centrality measure, ripple centrality, which measures how effectively a change at a particular node can ripple across the network by identifying highest activity paths specific to the condition of interest, obtained by mapping gene expression profiles to the PPI network. We demonstrate the algorithm using an overexpression study and a knockdown study. In the overexpression study, the gene that was overexpressed (PARK2) was highlighted as the most important epicenter specific to the perturbation. The other top-ranked epicenters were involved in either supporting the activity of PARK2, or counteracting it. Also, 5 of the identified epicenters showed no significant differential expression, showing that our method can find information which simple differential expression analysis cannot. In the second dataset (SP1 knockdown), alternative regulators of SP1 targets were highlighted as epicenters. Also, the gene that was knocked down (SP1) was picked up as an epicenter specific to the control condition. Sensitivity analysis showed that the genes identified as epicenters remain largely unaffected by small changes. We develop an algorithm, EpiTracer, to find epicenters in condition-specific biological networks, given the PPI network and gene expression levels. EpiTracer includes programs which can extract the

  20. MDRD or CKD-EPI for glomerular filtration rate estimation in living kidney donors.

    Science.gov (United States)

    Burballa, Carla; Crespo, Marta; Redondo-Pachón, Dolores; Pérez-Sáez, María José; Mir, Marisa; Arias-Cabrales, Carlos; Francés, Albert; Fumadó, Lluis; Cecchini, Lluis; Pascual, Julio

    2017-04-12

    The evaluation of the measured Glomerular Filtration Rate (mGFR) or estimated Glomerular Filtration Rate (eGFR) is key in the proper assessment of the renal function of potential kidney donors. We aim to study the correlation between glomerular filtration rate estimation equations and the measured methods for determining renal function. We analysed the relationship between baseline GFR values measured by Tc-(99)m-DTPA (diethylene-triamine-pentaacetate) and those estimated by the four-variable Modification of Diet in Renal Disease (MDRD4) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in a series of living donors at our institution. We included 64 donors (70.6% females; mean age 48.3±11 years). Baseline creatinine was 0.8±0.1 mg/dl and it was 1.1±0.2 mg/dl one year after donation. The equations underestimated GFR when measured by Tc(99)m-DTPA (MDRD4-9.4 ± 25ml/min, P<.05, and CKD-EPI-4.4 ± 21ml/min). The correlation between estimation equations and the measured method was superior for CKD-EPI (r=.41; P<.004) than for MDRD4 (r=.27; P<.05). eGFR decreased to 59.6±11 (MDRD4) and 66.2±14ml/min (CKD-EPI) one year after donation. This means a mean eGFR reduction of 28.2±16.7 ml/min (MDRD4) and 27.31±14.4 ml/min (CKD-EPI) at one year. In our experience, CKD-EPI is the equation that better correlates with mGFR-Tc(99)m-DTPA when assessing renal function for donor screening purposes. Copyright © 2017 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.

  1. Former WHK Intern Returns to NCI at Frederick as Earl-Stadtman Investigator | Poster

    Science.gov (United States)

    The Laboratory of Cell and Developmental Signaling (LCDS) recently welcomed John Brognard, Ph.D., as the new Earl-Stadtman Investigator. While Brognard is new to this role, he is not new to NCI at Frederick. In high school, Brognard was a Werner H. Kirsten Student Intern in what was formerly known as the ABL research program, where he worked under Bob Moschel, Ph.D., senior investigator, and Gary Pauly, Ph.D., currently a staff scientist in the Chemical Biology Laboratory.

  2. Test de visualitat: les preferències del bon disseny

    Directory of Open Access Journals (Sweden)

    Quim Merino

    2014-07-01

    Full Text Available Aquest article pretén donar notícia de la investigació dirigida pel Grup de Recerca en Publicitat i Relacions Públiques (en endavant, GRP de la Universitat Autònoma de Barcelona duta a terme pels autors d'aquesta ressenya. El treball s'emmarca en una activitat de l'assignatura de Disseny en Publicitat i Relacions Públiques del Grau en Publicitat i Relacions Públiques de la UAB. L'objectiu del treball és constatar les preferències del consumidor davant diferents estímuls formals del disseny gràfic en publicitat

  3. Microsoft Office 365 Deployment Continues through June at NCI at Frederick | Poster

    Science.gov (United States)

    The latest Microsoft suite, Office 365 (O365), is being deployed to all NCI at Frederick computers during the months of May and June to comply with federal mandates. The suite includes the latest versions of Word, Excel, Outlook, PowerPoint, and Skype for Business, along with cloud-based capabilities. These cloud-based capabilities will help meet the federal mandates that require all Health and Human Services operating divisions to migrate e-mail to the cloud by the end of 2016.

  4. On the recent large EQ of Karpathos, Greece (April 1st, 2011, Ms = 6.7R) and its similarities to the large EQ of the January 1st, 2006 (Ms = 6.9R) at East of Kythira, Greece

    CERN Document Server

    Thanassoulas, C; Verveniotis, G; Zymaris, N

    2011-01-01

    The recent large EQ that occurred in Greece (April 1st, 2011, Ms = 6.7R) is investigated as far as it concerns regional geophysical features of the Greek territory. In particular, the EQ location is compared to the deep lithospheric fracture zones and faults, derived from the analysis of the corresponding earth's gravity field; to the current seismic potential map determined from the study of the past seismicity, while its time of occurrence is compared to the peaks of the M1 and diurnal tidal waves. The detailed investigation of the earth's electric field that was recorded by the ATH monitoring site, located in Athens, revealed the presence of short train like pulses type electric seismic precursory signals which were generated short (1 - 2 days) before the EQ occurrence time. Moreover, the analysis (for T = 1 day) of the earth's oscillating electric field, that was simultaneously recorded at PYR and ATH monitoring sites, revealed that the "strange attractor like" seismic electric precursor preceded for 1 - ...

  5. Modification of diet in renal disease (MDRD study and CKD epidemiology collaboration (CKD-EPI equations for Taiwanese adults.

    Directory of Open Access Journals (Sweden)

    Ling-I Chen

    Full Text Available Estimated glomerular filtration rate (eGFR using the Modification of Diet in Renal Disease (MDRD study or the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI equations may not be accurate for Asians; thus, we developed modified eGFR equations for Taiwanese adults.This cross-sectional study compared the Taiwanese eGFR equations, the MDRD study, and the CKD-EPI equations with inulin clearance (Cin. A total of 695 adults including 259 healthy volunteers and 436 CKD patients were recruited. Participants from the Kaohsiung Medical University Hospital were used as the development set (N = 556 to develop the Taiwanese eGFR equations, whereas participants from the National Taiwan University Hospital were used as the validation set (N = 139 for external validation.The Taiwanese eGFR equations were developed by using the extended Bland-Altman plot in the development set. The Taiwanese MDRD equation was 1.309 × MDRD0.912, Taiwanese CKD-EPI was 1.262×CKD-EPI0.914 and Taiwanese four-level CKD-EPI was 1.205 × four-level CKD-EPI0.914. In the validation set, the Taiwanese equations had the lowest bias, the Taiwanese equations and the Japanese CKD-EPI equation had the lowest RMSE, whereas the Taiwanese and the Japanese equations had the best precision and the highest P30 among all equations. However, the Taiwanese MDRD equation had higher concordance correlation than did the Taiwanese CKD-EPI, the Taiwanese four-level CKD-EPI and the Japanese equations. Moreover, only the Taiwanese equations had no proportional bias among all of the equations. Finally, the Taiwanese MDRD equation had the best diagnostic performance in terms of ordinal logistic regression among all of the equations.The Taiwanese MDRD equation is better than the MDRD, CKD-EPI, Japanese, Asian, Thai, Taiwanese CKD-EPI, and Taiwanese four-level CKD-EPI equations for Taiwanese adults.

  6. U.S. Army Chemical Corps Historical Studies, Gas Warfare in World War I: The 1st Division in the Meuse-Argonne 1-12 October 1918

    Science.gov (United States)

    1957-08-01

    October, instead of 30 September-I October 0 On the night of the relief the .Jnemy began shelling at 10s00 porn October 1st and continued until 4s00... Juvin and Landre, out off the Argoure front, and attack in rear of the Brunhild position to effect decisive action on the Group -Argonnej." 8 7 At...attack, fired on the Son’.erance area and north of St Georges et Landres, Juvin , Marcq, and Champigxeulle. 93 Company C, 1st Gas Regiment, was ordered

  7. CFD analysis of the impingement cooling effect of the coolant jet caused by the T56 1st stage disc metering hole

    CSIR Research Space (South Africa)

    Snedden, Glen C

    2003-09-01

    Full Text Available OF THE IMPINGEMENT COOLING EFFECT OF THE COOLANT JET CAUSED BY THE T56 1ST STAGE DISC METERING HOLE ISABE-2003-1065 Glen C. Snedden CSIR, Defencetek, P O Box 395 Pretoria, 0001, South Africa Tony Lambert Rolls-Royce Indianapolis, Indiana, USA Abstract... the cavities via metering holes drilled through the curvic-coupling web. As a result of physical restrictions during the manufacturing process these holes are angled toward the face of the disc and result in flow impinging on the rear surface of the 1st...

  8. Invasive pneumococcal disease in healthy adults: increase of empyema associated with the clonal-type Sweden(1-ST306.

    Directory of Open Access Journals (Sweden)

    Imma Grau

    Full Text Available BACKGROUND: Adult invasive pneumococcal disease (IPD occurs mainly in the elderly and patients with co-morbidities. Little is known about the clinical characteristics, serotypes and genotypes causing IPD in healthy adults. METHODS: We studied 745 culture-proven cases of IPD in adult patients aged 18-64 years (1996-2010. Patients were included in two groups: 1. adults with co-morbidities, and 2. healthy adults, who had no prior or coincident diagnosis of a chronic or immunosuppressive underlying disease. Microbiological studies included pneumococcal serotyping and genotyping. RESULTS: Of 745 IPD episodes, 525 (70% occurred in patients with co-morbidities and 220 (30% in healthy adults. The healthy adults with IPD were often smokers (56% or alcohol abusers (18%. As compared to patients with co-morbidities, the healthy adults had (P<0.05: younger age (43.5+/-13.1 vs. 48.7+/-11.3 years; higher proportions of women (45% vs. 24%, pneumonia with empyema (15% vs. 7% and infection with non-PCV7 serotypes including serotypes 1 (25% vs. 5%, 7F (13% vs. 4%, and 5 (7% vs. 2%; and lower mortality (5% vs. 20%. Empyema was more frequently caused by serotype 1. No death occurred among 79 patients with serotype 1 IPD. There was an emergence of virulent clonal-types Sweden(1-ST306 and Netherlands(7F-ST191. The vaccine serotype coverage with the PCV13 was higher in healthy adults than in patients with co-morbidities: 82% and 56%, respectively, P<0.001. CONCLUSION: In this clinical study, one-third of adults with IPD had no underlying chronic or immunosuppressive diseases (healthy adults. They were often smokers and alcohol abusers, and frequently presents with pneumonia and empyema caused by virulent clones of non-PCV7 serotypes such as the Sweden(1-ST306. Thus, implementing tobacco and alcohol abuse-cessation measures and a proper pneumococcal vaccination, such as PCV13 policy, in active smokers and alcohol abusers may diminish the burden of IPD in adults.

  9. 1st EUCOMAS conference

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    The following topics were dealt with: CFC Infusion Technology - the Future for Commercial CFC Fuselages? Structural Optimization of Composite Aircraft Panels with Large Cut-Outs. Design and Analysis of Advanced Composite Load Introduction Structures for High Lift Devices. A new highly formable quasi-isotropic prepreg for complex shape parts - HexMC, a unique composite technology for new aerospace needs. Ultra Thick Laminates for Highly Loaded Main Landing Gear Fittings - Development of a main landing gear fitting in carbon fibre reinforced plastics. ''ScaLA'' -2nd generation of AlMgSc materials dedicated for short manufacturing chains in the aerospace industry. Latest generation of Al-Li alloys developed by Alcan Aerospace. Aleris' Advanced Aluminium Sheet and Plate Products for High-Performance Aircraft Applications. Mechanical and environmental validation of a spherical multipurpose inflatable structure. Design, Analysis and Manufacturing of a Thermoplastic Slat. Novel load-introduction systems for lightweight aircraft components in composite-metal-hybrid design - Multi-Materials Design for lightweight hydraulic actuators. SiC-fibre reinforced titanium shafts under multiaxial loading - Tests and numerical simulations for torsion and tension loading. New Design Philosophy for Improvement of Damage Tolerance of Welded Airframe Structure. New Approaches for the Flexible Manufacturing of Helicopter FRP-structures. Development of an innovative process for the manufacture of composite components. Thermoplastic Technologies - An Alternative for Aircraft Structures. New Prepreg Materials for Crushed Core Technology - Influence of Cure Cycle on Flammability and Fracture Toughness. Influence of Heat Treatment on Mechanical Properties of Ti-5Al-5V-5Mo-3Cr. Manufacturing and Properties of Induction Welded Metal/Composite Joints. Multi-Physics Modelling of Bobbin-Tool Friction Stir Welding - Applications to a latest generation aluminium Alloy - A simple numerical model supports the development of FSW technology. ABiTAS - Advanced Bonding Technologies for Aircraft Structures. Individual Laser Cladding for High Pressure Turbine Blades. Advanced high temperature repair brazing for single crystal and directionally solidified turbine components. Thermoplastic Tape Placement - Challenging the Autoclave Process. Modern Methods of Preforming Titanium Alloys for Forging Aero Engine Vanes. Ultrasonic Shot Peening for Ti-6Al-4V Aero-Engine Components. Stiffening spherical panels by means of modern braiding processes. Potential and Challenges of Fibre Reinforced Ceramics in Gas Turbines. Development of a nickel alloy for disc applications. Application of Thermal Barrier Coatings on Intermetallic Turbine Blade Materials. Development and Validation of A Dual Titanium Alloy Dual-Microstructure BLISK. PTAH-Socar Fuel-Cooled Composite Materials Structure. Manufacturing Methods and Typical Applications of C/C-SiC Materials Based on the Liquid Silicon Infiltration Process (LSI) - Non brittle C/C-SiC materials based on filament winding. Dilution phenomenon during coating of titanium alloys by Plasma Transferred Arc (PTA) process. Tools, processes and examples of Space Structures Optimisation. Topology Optimisation in the Design Process of Light Weight Structural Components for Aeroengines. Residual strength prediction of integral structures using numerical crack extension analyses. Finite element based optimization of a novel metal-composite-joint. Investigations on the pulsed MIG/MAG welding of dissimilar austenitic-ferritic steels (W7335-X10CrNiTi18.9). Isothermal Oxidation Behaviour and Microstructure of the single crystal superalloy PWA 1483 at 950 C. The Use of Fluorine for the Protection of TiAl-Components against High-Temperature Oxidation. Stability Estimation for Stiffened Structures Considering Laser Beam Welded Stringers - comparision of methods to estimate fuselage buckling behaviour. New design concept for integral manufacturing of high performance composite parts. Structural Adhesives with Debonding Ability for R

  10. EpiTools: An Open-Source Image Analysis Toolkit for Quantifying Epithelial Growth Dynamics.

    Science.gov (United States)

    Heller, Davide; Hoppe, Andreas; Restrepo, Simon; Gatti, Lorenzo; Tournier, Alexander L; Tapon, Nicolas; Basler, Konrad; Mao, Yanlan

    2016-01-11

    Epithelia grow and undergo extensive rearrangements to achieve their final size and shape. Imaging the dynamics of tissue growth and morphogenesis is now possible with advances in time-lapse microscopy, but a true understanding of their complexities is limited by automated image analysis tools to extract quantitative data. To overcome such limitations, we have designed a new open-source image analysis toolkit called EpiTools. It provides user-friendly graphical user interfaces for accurately segmenting and tracking the contours of cell membrane signals obtained from 4D confocal imaging. It is designed for a broad audience, especially biologists with no computer-science background. Quantitative data extraction is integrated into a larger bioimaging platform, Icy, to increase the visibility and usability of our tools. We demonstrate the usefulness of EpiTools by analyzing Drosophila wing imaginal disc growth, revealing previously overlooked properties of this dynamic tissue, such as the patterns of cellular rearrangements.

  11. ANALYSIS AND MODELING OF EDUCATION PARTICIPATION INDEX (EPI IN INDONESIA FROM 2003-2008

    Directory of Open Access Journals (Sweden)

    Mustofa Usman

    2013-02-01

    Full Text Available The aims of the research is to reveal the characteristics of the Education Participation Index (EPI in Indonesia based on the level of students’ age (7-12, 13-15, 16-18, and 19-24 which shows the participation index of the citizens at Elementary School, Junior High School, Senior High School and University. The data was taken from Central Bureau Statistics of Indonesia (BPS from the year 2003 to 2008. The data is analyzed to see the difference between the level of ages at difference regions and difference years. And the data was analyzed by using analysis nested design. The second analysis is to find the EPI model for each regions and years. The modeling is used the multiple linear regression with dummy variable for the regions and years.

  12. 8-epi-Salvinorin B: crystal structure and affinity at the κ opioid receptor

    Directory of Open Access Journals (Sweden)

    Béguin Cécile

    2007-01-01

    Full Text Available Abstract There have been many reports of epimerization of salvinorins at C-8 under basic conditions, but little evidence has been presented to establish the structure of these compounds. We report here the first crystal structure of an 8-epi-salvinorin or derivative: the title compound, 2b. The lactone adopts a boat conformation with the furan equatorial. Several lines of evidence suggest that epimerization proceeds via enolization of the lactone rather than a previously proposed indirect mechanism. Consistent with the general trend in related compounds, the title compound showed lower affinity at the kappa opioid receptor than the natural epimer salvinorin B (2a. The related 8-epi-acid 4b showed no affinity.

  13. Relations between performance on the advance matrices and the EPI in high-intelligence subjects.

    Science.gov (United States)

    Gibson, H B

    1975-11-01

    This study continues the investigation of the relationship between performance on tests of intelligence, and the personality parameters of the Eysenckian theoretical framework. Candidates for admission to an honours degree course (n = 281) were given the Advanced Progressive Matrices as a screening device. Those admitted to the course were on later occasions given both forms of the Eysenck Personality Inventory (EPI). In view of problems of test-retest on the EPI, scores were analysed in a novel fashion to give three groups: 'introverts', 'extraverts' and 'ambiverts'. The 'introverts' scored significantly highest on the Matrices, but the scores of the 'ambiverts' were lowest. Neuroticism showed little interaction with other variables. These results are discussed in terms of the theory of reactive inhibition. New data on the Advanced Progressive Matrices are given which are significantly higher than the published university norms.

  14. Designing the Expanded Programme on Immunisation (EPI) as a service: Prioritising patients over administrative logic

    DEFF Research Database (Denmark)

    McKnight, J.; Holt, D. B.

    2014-01-01

    Expanded Programme on Immunisation (EPI) vaccination rates remain well below herd immunity in regions of many countries despite huge international resources devoted to both financing and access. We draw upon service marketing theory, organisational sociology, development anthropology and cultural...... consumer research to conduct an ethnographic study of vaccination delivery in Jimma Zone, Ethiopia - one such region. We find that Western public health sector policies are dominated by an administrative logic. Critical failures in delivery are produced by a system that obfuscates the on...

  15. Automatic Tracking Radar Career Ladder, AFSC-303X3. Electronics Principles Inventory (EPI).

    Science.gov (United States)

    1981-02-01

    81 UNCLASSIFIED NL mhhmI/I/II///IEEIIIIEIIIIIEE EIIIIEEEEIIIII UNITED STATES AIR FORCE ELECTRONICS PRINCIPLES INVENTORY (EPI),., / b AUTOMATIC...presents the preliminary results of an Air Force Electronics Principles Survey of the Automatic Tracking Radar career ladder (AFSC 303X3). The project was...undertaken at the request of Mr. James R. Haupt, Training Manager, Keesler AFB, MS. Authority for conducting electronics principles inventories is

  16. Clinically feasible NODDI characterization of glioma using multiband EPI at 7 T

    Directory of Open Access Journals (Sweden)

    Qiuting Wen

    2015-01-01

    Full Text Available Recent technological progress in the multiband echo planer imaging (MB EPI technique enables accelerated MR diffusion weighted imaging (DWI and allows whole brain, multi-b-value diffusion imaging to be acquired within a clinically feasible time. However, its applications at 7 T have been limited due to B1 field inhomogeneity and increased susceptibility artifact. It is an ongoing debate whether DWI at 7 T can be performed properly in patients, and a systematic SNR comparison for multiband spin-echo EPI between 3 T and 7 T has not been methodically studied. The goal of this study was to use MB EPI at 7 T in order to obtain 90-directional multi-shell DWI within a clinically feasible acquisition time for patients with glioma. This study included an SNR comparison between 3 T and 7 T, and the application of B1 mapping and distortion correction procedures for reducing the impact of variations in B0 and B1. The optimized multiband sequence was applied in 20 patients with glioma to generate both DTI and NODDI maps for comparison of values in tumor and normal appearing white matter (NAWM. Our SNR analysis showed that MB EPI at 7 T was comparable to that at 3 T, and the data quality acquired in patients was clinically acceptable. NODDI maps provided unique contrast within the T2 lesion that was not seen in anatomical images or DTI maps. Such contrast may reflect the complexity of tissue compositions associated with disease progression and treatment effects. The ability to consistently obtain high quality diffusion data at 7 T will contribute towards the implementation of a comprehensive brain MRI examination at ultra-high field.

  17. Evaluation of Multiband EPI Acquisitions for Resting State fMRI.

    Directory of Open Access Journals (Sweden)

    Christine Preibisch

    Full Text Available Functional magnetic resonance imaging (fMRI and particularly resting state fMRI (rs-fMRI is widely used to investigate resting state brain networks (RSNs on the systems level. Echo planar imaging (EPI is the state-of-the-art imaging technique for most fMRI studies. Therefore, improvements of EPI might lead to increased sensitivity for a large amount of studies performed every day. A number of developments to shorten acquisition time have been recently proposed and the multiband technique, allowing the simultaneous acquisition of multiple slices yielding an equivalent reduction of measurement time, is the most promising among them. While the prospect to significantly reduce acquisition time by means of high multiband acceleration factors (M appears tempting, signal quality parameters and the sensitivity to detect common RSNs with increasing M-factor have only been partially investigated up to now. In this study, we therefore acquired rs-fMRI data from 20 healthy volunteers to systematically investigate signal characteristics and sensitivity for brain network activity in datasets with increasing M-factor, M = 2 - 4. Combined with an inplane, sensitivity encoding (SENSE, acceleration factor, S = 2, we applied a maximal acceleration factor of 8 (S2×M4. Our results suggest that an M-factor of 2 (total acceleration of 4 only causes negligible SNR decrease but reveals common RSN with increased sensitivity and stability. Further M-factor increase produced random artifacts as revealed by signal quality measures that may affect interpretation of RSNs under common scanning conditions. Given appropriate hardware, a mb-EPI sequence with a total acceleration of 4 significantly reduces overall scanning time and clearly increases sensitivity to detect common RSNs. Together, our results suggest mb-EPI at moderate acceleration factors as a novel standard for fMRI that might increase our understanding of network dynamics in healthy and diseased brains.

  18. Simultaneous Reduction of Two Common Autocalibration Errors in GRAPPA EPI Time Series Data

    CERN Document Server

    Sheltraw, D; Deshpande, V; Trumpis, M

    2012-01-01

    The GRAPPA (GeneRalized Autocalibrating Partially Parallel Acquisitions) method of parallel MRI makes use of an autocalibration scan (ACS) to determine a set of synthesis coefficients to be used in the image reconstruction. For EPI time series the ACS data is usually acquired once prior to the time series. In this case the interleaved R-shot EPI trajectory, where R is the GRAPPA reduction factor, offers advantages which we justify from a theoretical and experimental perspective. Unfortunately, interleaved R-shot ACS can be corrupted due to perturbations to the signal (such as direct and indirect motion effects) occurring between the shots, and these perturbations may lead to artifacts in GRAPPA-reconstructed images. Consequently we also present a method of acquiring interleaved ACS data in a manner which can reduce the effects of inter-shot signal perturbations. This method makes use of the phase correction data, conveniently a part of many standard EPI sequences, to assess the signal perturbations between th...

  19. Dual-Utility of Digital Holography & Epi-Fluorescence to Localize Cellular Nuclei

    Science.gov (United States)

    Sheldrake, Eric

    Digital Holographic Microscopy (DHM) and Epi-Fluorescence have been combined for biological imaging. DHM is a non-invasive phase contrast microscopy technique that provides quantitative information such as the variations in refractive index and physical height. 3D physical height and refractive index profiles are imaged for HEK293 and CHO cells. These values and profiles are compared with known values for the sample gathered from literature and other microscopy techniques, including Scanning Electron Microscopy. The measured CHO cellular length is (15.31 +/- 2.60) microm. Localization of cellular nuclei is performed using the Epi-Fluorescence setup and the DNA specific fluorophore DAPI. The fluorescence intensity profile was imaged, where nuclei shape, size, and localization are compared using an A.1 Zeiss Fluorescence Microscope. The CHO cells are comparable with apoptotic cells, where the measured nucleus length is (10.91 +/- 2.27) microm. DHM and Epi-Fluorescence are combined to analyze the physical heights of the cell as well as localize its nucleus. The combination of these techniques are greatly advantageous to understand cellular functions and variability.

  20. Accurate alignment of functional EPI data to anatomical MRI using a physics-based distortion model.

    Science.gov (United States)

    Studholme, C; Constable, R T; Duncan, J S

    2000-11-01

    Mapping of functional magnetic resonance imaging (fMRI) to conventional anatomical MRI is a valuable step in the interpretation of fMRI activations. One of the main limits on the accuracy of this alignment arises from differences in the geometric distortion induced by magnetic field inhomogeneity. This paper describes an approach to the registration of echo planar image (EPI) data to conventional anatomical images which takes into account this difference in geometric distortion. We make use of an additional spin echo EPI image and use the known signal conservation in spin echo distortion to derive a specialized multimodality nonrigid registration algorithm. We also examine a plausible modification using log-intensity evaluation of the criterion to provide increased sensitivity in areas of low EPI signal. A phantom-based imaging experiment is used to evaluate the behavior of the different criteria, comparing nonrigid displacement estimates to those provided by a imagnetic field mapping acquisition. The algorithm is then applied to a range of nine brain imaging studies illustrating global and local improvement in the anatomical alignment and localization of fMRI activations.

  1. Effects of EPI distortion correction pipelines on the connectome in Parkinson's Disease

    Science.gov (United States)

    Galvis, Justin; Mezher, Adam F.; Ragothaman, Anjanibhargavi; Villalon-Reina, Julio E.; Fletcher, P. Thomas; Thompson, Paul M.; Prasad, Gautam

    2016-03-01

    Echo-planar imaging (EPI) is commonly used for diffusion-weighted imaging (DWI) but is susceptible to nonlinear geometric distortions arising from inhomogeneities in the static magnetic field. These inhomogeneities can be measured and corrected using a fieldmap image acquired during the scanning process. In studies where the fieldmap image is not collected, these distortions can be corrected, to some extent, by nonlinearly registering the diffusion image to a corresponding anatomical image, either a T1- or T2-weighted image. Here we compared two EPI distortion correction pipelines, both based on nonlinear registration, which were optimized for the particular weighting of the structural image registration target. The first pipeline used a 3D nonlinear registration to a T1-weighted target, while the second pipeline used a 1D nonlinear registration to a T2-weighted target. We assessed each pipeline in its ability to characterize high-level measures of brain connectivity in Parkinson's disease (PD) in 189 individuals (58 healthy controls, 131 people with PD) from the Parkinson's Progression Markers Initiative (PPMI) dataset. We computed a structural connectome (connectivity map) for each participant using regions of interest from a cortical parcellation combined with DWI-based whole-brain tractography. We evaluated test-retest reliability of the connectome for each EPI distortion correction pipeline using a second diffusion scan acquired directly after the participants' first. Finally, we used support vector machine (SVM) classification to assess how accurately each pipeline classified PD versus healthy controls using each participants' structural connectome.

  2. DESIGN OF LOW EPI AND HIGH THROUGHPUT CORDIC CELL TO IMPROVE THE PERFORMANCE OF MOBILE ROBOT

    Directory of Open Access Journals (Sweden)

    P. VELRAJKUMAR

    2014-04-01

    Full Text Available This paper mainly focuses on pass logic based design, which gives an low Energy Per Instruction (EPI and high throughput COrdinate Rotation Digital Computer (CORDIC cell for application of robotic exploration. The basic components of CORDIC cell namely register, multiplexer and proposed adder is designed using pass transistor logic (PTL design. The proposed adder is implemented in bit-parallel iterative CORDIC circuit whereas designed using DSCH2 VLSI CAD tool and their layouts are generated by Microwind 3 VLSI CAD tool. The propagation delay, area and power dissipation are calculated from the simulated results for proposed adder based CORDIC cell. The EPI, throughput and effect of temperature are calculated from generated layout. The output parameter of generated layout is analysed using BSIM4 advanced analyzer. The simulated result of the proposed adder based CORDIC circuit is compared with other adder based CORDIC circuits. From the analysis of these simulated results, it was found that the proposed adder based CORDIC circuit dissipates low power, gives faster response, low EPI and high throughput.

  3. Study of clutter origin in in-vivo epi-optoacoustic imaging of human forearms

    Science.gov (United States)

    Preisser, Stefan; Held, Gerrit; Akarçay, Hidayet G.; Jaeger, Michael; Frenz, Martin

    2016-09-01

    Epi-optoacoustic (OA) imaging offers flexible clinical diagnostics of the human body when the irradiation optic is attached to or directly integrated into the acoustic probe. Epi-OA images, however, encounter clutter that deteriorates contrast and significantly limits imaging depth. This study elaborates clutter origin in clinical epi-optoacoustic imaging using a linear array probe for scanning the human forearm. We demonstrate that the clutter strength strongly varies with the imaging location but stays stable over time, indicating that clutter is caused by anatomical structures. OA transients which are generated by strong optical absorbers located at the irradiation spot were identified to be the main source of clutter. These transients obscure deep in-plane OA signals when detected by the transducer either directly or after being acoustically scattered in the imaging plane. In addition, OA transients generated in the skin below the probe result in acoustic reverberations, which cause problems in image interpretation and limit imaging depth. Understanding clutter origin allows a better interpretation of clinical OA imaging, helps to design clutter compensation techniques and raises the prospect of contrast optimization via the design of the irradiation geometry.

  4. A method of generalized projections (MGP) ghost correction algorithm for interleaved EPI.

    Science.gov (United States)

    Lee, K J; Papadakis, N G; Barber, D C; Wilkinson, I D; Griffiths, P D; Paley, M N J

    2004-07-01

    Investigations into the method of generalized projections (MGP) as a ghost correction method for interleaved EPI are described. The technique is image-based and does not require additional reference scans. The algorithm was found to be more effective if a priori knowledge was incorporated to reduce the degrees of freedom, by modeling the ghosting as arising from a small number of phase offsets. In simulations with phase variation between consecutive shots for n-interleaved echo planar imaging (EPI), ghost reduction was achieved for n = 2 only. With no phase variation between shots, ghost reduction was obtained with n up to 16. Incorporating a relaxation parameter was found to improve convergence. Dependence of convergence on the region of support was also investigated. A fully automatic version of the method was developed, using results from the simulations. When tested on in vivo 2-, 16-, and 32-interleaved spin-echo EPI data, the method achieved deghosting and image restoration close to that obtained by both reference scan and odd/even filter correction, although some residual artifacts remained.

  5. epiDMS: Data Management and Analytics for Decision-Making From Epidemic Spread Simulation Ensembles.

    Science.gov (United States)

    Liu, Sicong; Poccia, Silvestro; Candan, K Selçuk; Chowell, Gerardo; Sapino, Maria Luisa

    2016-12-01

    Carefully calibrated large-scale computational models of epidemic spread represent a powerful tool to support the decision-making process during epidemic emergencies. Epidemic models are being increasingly used for generating forecasts of the spatial-temporal progression of epidemics at different spatial scales and for assessing the likely impact of different intervention strategies. However, the management and analysis of simulation ensembles stemming from large-scale computational models pose challenges, particularly when dealing with multiple interdependent parameters, spanning multiple layers and geospatial frames, affected by complex dynamic processes operating at different resolutions. We describe and illustrate with examples a novel epidemic simulation data management system, epiDMS, that was developed to address the challenges that arise from the need to generate, search, visualize, and analyze, in a scalable manner, large volumes of epidemic simulation ensembles and observations during the progression of an epidemic. epiDMS is a publicly available system that facilitates management and analysis of large epidemic simulation ensembles. epiDMS aims to fill an important hole in decision-making during healthcare emergencies by enabling critical services with significant economic and health impact.

  6. The 1st Euro-Mediterranean Workshop: Natural Products in Health and Diseases: Cairo, Egypt, March 2, 2015

    Directory of Open Access Journals (Sweden)

    Kamal D. Moudgil

    2016-04-01

    Full Text Available Natural plant products have been used for centuries for health maintenance and treatment of a variety of diseases in various traditional systems of medicine in Egypt and other African countries, India, China, and other countries around the world. Over the past several decades, the popularity of herbal and other natural products has gradually increased in many western countries. Despite the increasing popularity of natural products, both the public and the professionals are skeptical about the use of these products. Reasons for this skepticism include, but are not limited to, the lack of proper documentation about the source and formulations used; standardization of the composition, batch-to-batch consistency, documented safety of herbal products; and information about the mechanisms of action of these products. The 1st Euro-Mediterranean Workshop: Natural Products in Health and Diseases was organized by the Euro-Mediterranean Association of Life Sciences (EMALS and various other local organizations to review and discuss the above-mentioned strengths and limitations of the use of natural products. The aim of this workshop was to share best practices and expertise about natural products, and to identify opportunities for collaboration among researchers, health professionals, and business personnel in a productive atmosphere.

  7. Grammar Instruction in the 1st Grade of Senior High School: a Comparative Study of two Methods

    Directory of Open Access Journals (Sweden)

    Argyro Vagiatidou

    2010-02-01

    Full Text Available The present dissertation endeavours to investigate the effectiveness of two opposing grammar teaching approaches on students’ performance in the 1st grade of a Greek State Senior High School. This study, in particular, compares the learning outcomes of the meaning-focused grammar teaching approach, based on a communication-based perspective of language against the outcomes of traditional, structure-based teaching. For the collection of data, a pretest-posttest experiment was conducted, involving the teaching of the Reported speech grammar form to two groups of randomly selected students in a Greek Senior High School. One group of students attended a series of lessons on the Reported Speech through the structure-based approach, while the other one was presented with the same structure in a meaning-focused way. The study has found significant statistical differences in favour of the meaning-focused teaching approach, as it was demonstrated by the outcome that the students of the relevant group were far more successful when compared to their schoolmates of the other group in their attempts to form Reported Speech promptly and accurately as well as use it in a quite fluent way to accomplish relevant contextualised tasks.

  8. 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies

    CERN Document Server

    Kramar, Peter

    2016-01-01

    This volume presents the proceedings of the 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies (WC2015). The congress took place in Portorož, Slovenia, during the week of September 6th to 10th, 2015. The scientific part of the Congress covered different aspects of electroporation and related technologies and included the following main topics:   ·         Application of pulsed electric fields technology in food: challenges and opportunities ·         Electrical impedance measurement for assessment of electroporation yield ·         Electrochemistry and electroporation ·         Electroporation meets electrostimulation ·         Electrotechnologies for food and biomass treatment ·         Food and biotechnology applications ·         In vitro electroporation - basic mechanisms ·         Interfacial behaviour of lipid-assemblies, membranes and cells in electric f...

  9. Synthesis of nanomagnetic fluids and their UV spectrophotometric response with aliphatic organic acids and 1st tier dendrimers

    Science.gov (United States)

    Pandya, Shivani R.; Singh, Man

    2016-04-01

    Synthesis of Magnetic nanoparticles were made using coprecipitation method on mixing Fe+3 and Fe+2 in 2:1 ratio with aqueous 8M NaOH which on heating at 90°C for 2 h has yielded 85% magnetic (Fe3O4) nanoparticles (MNPs), characterized by XRD, VSM, SEM, and HR-TEM. The formic acid (FA), oxalic acid (OA) and citric acid (CA), the series of aliphatic organic acids along with Trimesoyl 1, 3, 5 tridimethyl malonate (TTDMM), trimesoyl 1, 3, 5 tridiethyl malonate (TTDEM), trimesoyl 1, 3, 5 tridipropyl malonate (TTDPM), trimesoyl 1, 3, 5 tridibutyl malonate (TTDBM) and trimesoyl 1, 3, 5 tridihexyl malonate (TTDHM) 1st tier dendrimers were used separately for preparing nanomagnetic fluid. From 25 to 150 µM MNPs at an interval of 25 µM were dispersed in 150 µM of acids and dendrimers separately with DMSO. UV-VIS spectrophotometry showed a maximum MNPs dispersion with TTDMM against others and found to be most stable nanomagnetic fluid on account of capping type mechanism of acids.

  10. Child gender and weight status moderate the relation of maternal feeding practices to body esteem in 1st grade children.

    Science.gov (United States)

    Shriver, Lenka H; Hubbs-Tait, Laura; Harrist, Amanda W; Topham, Glade; Page, Melanie

    2015-06-01

    Prevention of body dissatisfaction development is critical for minimizing adverse effects of poor body esteem on eating behaviors, self-esteem, and overall health. Research has examined body esteem and its correlates largely in pre-adolescents and adolescents; however, important questions remain about factors influencing body esteem of younger children. The main purpose of this study was to test moderation by children's gender and weight status of the relation of maternal controlling feeding practices to 1st graders' body esteem. The Body Esteem Scale (BES) and anthropometric measurements were completed during one-on-one child interviews at school. Mothers completed the Child Feeding Questionnaire (restriction, monitoring, concern, self-assessed maternal weight). A total of 410 mother/child dyads (202 girls) participated. Percent of children classified as overweight (BMI-for-age ≥85th) was: girls - 29%; boys - 27%. Gender moderated the relation between restriction and body esteem (β = -.140, p = .05), with maternal restriction predicting body esteem in girls but not boys. The hypothesized three-way interaction among gender, child weight status, and monitoring was confirmed. Monitoring was significantly inversely related to body esteem only for overweight/obese girls (b = -1.630). The moderating influence of gender or gender and weight status on the link between maternal feeding practices and body esteem suggests the importance of body esteem interventions for girls as early as first grade.

  11. Palaeopathology of human remains of the 1st century BC–3rd century AD from Armenia (Beniamin, Shirakavan I

    Directory of Open Access Journals (Sweden)

    Khudaverdyan Anahit Yu.

    2015-06-01

    Full Text Available The aim of this article was to document the pathology of the individuals from the archeological sites of Beniamin and Shirakavan I, Armenia, dated on the 1st century BC - 3rd century AD. The findings revealed that two groups differed in mean age at death of adults. At Beniamin it was 24 years, 40.8 years for males and 30.9 years for females, whereas at Shirakavanit it was 29.3 years, 29.6 years for males and 35.8 years for females. The greatest mortality appeared to have occurred when the children reached the age of one year (Beniamin. The population had high number of young-adult females with a cause of death associated with child-bearing. Very few females survived to old age. Traumatic conditions (63.64% and enamel hypoplasias (57.2% have a high frequency in the skeletal material from Shirakavan. The volume of selection of Shirakavan does not allow itself to so big discussion as it was possible with the Beniamin site. Fewer hypoplasias in Beniamin group indicate that food resources were more abundant and more easily exploited. The small frequency of a periodontal disorder indicates that dental hygiene was good during the Antiquity period. We here report a case of possible pituitary dwarfism and a case of decapitation.

  12. 1st Quarter Transportation Report FY 2015: Radioactive Waste Shipments to and from the Nevada National Security Site (NNSS)

    Energy Technology Data Exchange (ETDEWEB)

    Gregory, Louis [National Security Technologies, LLC, Las Vegas, NV (United States)

    2015-02-20

    This report satisfies the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office (NNSA/NFO) commitment to prepare a quarterly summary report of radioactive waste shipments to and from the Nevada National Security Site (NNSS) Radioactive Waste Management Complex (RWMC) at Area 5. There were no shipments sent for offsite treatment and returned to the NNSS this quarter. This report summarizes the 1st quarter of Fiscal Year (FY) 2015 low-level radioactive waste (LLW) and mixed low-level radioactive waste (MLLW) shipments. Tabular summaries are provided which include the following: Sources of and carriers for LLW and MLLW shipments to and from the NNSS; Number and external volume of LLW and MLLW shipments; Highway routes used by carriers; and Incident/accident data applicable to LLW and MLLW shipments. In this report shipments are accounted for upon arrival at the NNSS, while disposal volumes are accounted for upon waste burial. The disposal volumes presented in this report include minor volumes of non-radioactive classified waste/material that were approved for disposal (non-radioactive classified or nonradioactive classified hazardous). Volume reports showing cubic feet generated using the Low-Level Waste Information System may vary slightly due to rounding conventions for volumetric conversions from cubic meters to cubic feet.

  13. NCI Workshop Report: Clinical and Computational Requirements for Correlating Imaging Phenotypes with Genomics Signatures

    Directory of Open Access Journals (Sweden)

    Rivka Colen

    2014-10-01

    Full Text Available The National Cancer Institute (NCI Cancer Imaging Program organized two related workshops on June 26–27, 2013, entitled “Correlating Imaging Phenotypes with Genomics Signatures Research” and “Scalable Computational Resources as Required for Imaging-Genomics Decision Support Systems.” The first workshop focused on clinical and scientific requirements, exploring our knowledge of phenotypic characteristics of cancer biological properties to determine whether the field is sufficiently advanced to correlate with imaging phenotypes that underpin genomics and clinical outcomes, and exploring new scientific methods to extract phenotypic features from medical images and relate them to genomics analyses. The second workshop focused on computational methods that explore informatics and computational requirements to extract phenotypic features from medical images and relate them to genomics analyses and improve the accessibility and speed of dissemination of existing NIH resources. These workshops linked clinical and scientific requirements of currently known phenotypic and genotypic cancer biology characteristics with imaging phenotypes that underpin genomics and clinical outcomes. The group generated a set of recommendations to NCI leadership and the research community that encourage and support development of the emerging radiogenomics research field to address short-and longer-term goals in cancer research.

  14. Receptor-Based Virtual Screening of EGFR Kinase Inhibitors from the NCI Diversity Database

    Directory of Open Access Journals (Sweden)

    Kiattawee Choowongkomon

    2010-06-01

    Full Text Available Epidermal growth factor receptor (EGFR abnormalities have been associated with several types of human cancer. The crystal structures of its tyrosine kinase domain (EGFR-TK complexed with small molecule inhibitors revealed the kinase inhibition modes, prompting us to search for novel anti-cancer drugs. A total of 1,990 compounds from the National Cancer Institute (NCI diversity set with nonredundant structures have been tested to inhibit cancer cell lines with unknown mechanism. Cancer inhibition through EGFR-TK is one of the mechanisms of these compounds. In this work, we performed receptor-based virtual screening against the NCI diversity database. Using two different docking algorithms, AutoDock and Gold, combined with subsequent post-docking analyses, we found eight candidate compounds with high scoring functions that all bind to the ATP-competitive site of the kinase. None of these compounds belongs to the main group of the currently known EGFR-TK inhibitors. Binding mode analyses revealed that the way these compounds complexed with EGFR-TK differs from quinazoline inhibitor binding and the interaction mainly involves hydrophobic interactions. Also, the common kinase-inhibitor (NH---N and CO---HC hydrogen bonds between the hinge region and the hit compounds are rarely observed. Our results suggest that these molecules could be developed as novel lead compounds in anti-cancer drug design.

  15. Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells.

    Directory of Open Access Journals (Sweden)

    Andrea Hirsch

    Full Text Available Regulation of human androgen biosynthesis is poorly understood. However, detailed knowledge is needed to eventually solve disorders with androgen dysbalance. We showed that starvation growth conditions shift steroidogenesis of human adrenal NCI-H295R cells towards androgen production attributable to decreased HSD3B2 expression and activity and increased CYP17A1 phosphorylation and 17,20-lyase activity. Generally, starvation induces stress and energy deprivation that need to be counteracted to maintain proper cell functions. AMP-activated protein kinase (AMPK is a master energy sensor that regulates cellular energy balance. AMPK regulates steroidogenesis in the gonad. Therefore, we investigated whether AMPK is also a regulator of adrenal steroidogenesis. We hypothesized that starvation uses AMPK signaling to enhance androgen production in NCI-H295R cells. We found that AMPK subunits are expressed in NCI-H295 cells, normal adrenal tissue and human as well as pig ovary cells. Starvation growth conditions decreased phosphorylation, but not activity of AMPK in NCI-H295 cells. In contrast, the AMPK activator 5-aminoimidazole-4-carboxamide (AICAR increased AMPKα phosphorylation and increased CYP17A1-17,20 lyase activity. Compound C (an AMPK inhibitor, directly inhibited CYP17A1 activities and can therefore not be used for AMPK signaling studies in steroidogenesis. HSD3B2 activity was neither altered by AICAR nor compound C. Starvation did not affect mitochondrial respiratory chain function in NCI-H295R cells suggesting that there is no indirect energy effect on AMPK through this avenue. In summary, starvation-mediated increase of androgen production in NCI-H295 cells does not seem to be mediated by AMPK signaling. But AMPK activation can enhance androgen production through a specific increase in CYP17A1-17,20 lyase activity.

  16. A diastereoselective cyclic imine cycloaddition strategy to access polyhydroxylated indolizidine skeleton: concise syntheses of (+)-/(-)-lentiginosines and (-)-2-epi-steviamine.

    Science.gov (United States)

    Shao, Jia; Yang, Jin-Song

    2012-09-21

    We describe in this paper the development of a novel diastereoselective cyclic imine cycloaddition strategy to access the polyhydroxylated indolizidine skeleton and its application in the concise syntheses of (+)-/(-)-lentiginosines and (-)-2-epi-steviamine.

  17. Experimental observations on the response of 1(st) and 2(nd) order fibre optic long period grating coupling bands to the deposition of nanostructured coatings.

    Science.gov (United States)

    James, Stephen W; Cheung, C S; Tatam, Ralph P

    2007-10-01

    The sensitivity of attenuation bands corresponding to the 2(nd) order coupling to cladding modes by a fibre optic long period grating (LPG) to the deposition of nanostructured coatings is investigated and compared with that of the 1(st) order coupling. The experimental observations support previously reported theoretical descriptions of LPGs with nanoscale coatings.

  18. Hybrid distributed Raman amplification combining random fiber laser based 2nd-order and low-noise LD based 1st-order pumping.

    Science.gov (United States)

    Jia, Xin-Hong; Rao, Yun-Jiang; Yuan, Cheng-Xu; Li, Jin; Yan, Xiao-Dong; Wang, Zi-Nan; Zhang, Wei-Li; Wu, Han; Zhu, Ye-Yu; Peng, Fei

    2013-10-21

    A configuration of hybrid distributed Raman amplification (H-DRA), that is formed by incorporating a random fiber laser (RFL) based 2nd-order pump and a low-noise laser-diode (LD) based 1st-order pump, is proposed in this paper. In comparison to conventional bi-directional 1st-order DRA, the effective noise figure (ENF) is found to be lower by amount of 0 to 4 dB due to the RFL-based 2nd-order pump, depending on the on-off gain, while the low-noise 1st-order Raman pump is used for compensating the worsened signal-to-noise ratio (SNR) in the vicinity towards the far end of the fiber and avoiding the potential nonlinear impact induced by excess injection of pump power and suppressing the pump-signal relative intensity noise (RIN) transfer. As a result, the gain distribution can be optimized along ultra-long fiber link, due to combination of the 2nd-order RFL and low-noise 1st-order pumping, making the transmission distance be extended significantly. We utilized such a configuration to achieve ultra-long-distance distributed sensing based on Brillouin optical time-domain analysis (BOTDA). A repeater-less sensing distance record of up to 154.4 km with 5 m spatial resolution and ~ ± 1.4 °C temperature uncertainty is successfully demonstrated.

  19. Moving beyond the Lone Scientist: Helping 1st-Grade Students Appreciate the Social Context of Scientific Work Using Stories about Scientists

    Science.gov (United States)

    Sharkawy, Azza

    2009-01-01

    While several studies have documented young children's (K-2) stereotypic views of scientists and scientific work, few have examined students' views of the social nature of scientific work and the strategies effective in broadening these views. The purpose of this study is to examine how stories about scientists influence 1st-grade students' views…

  20. Pre-Proceedings of the 1st International Workshop on Process-oriented Information Systems in Healthcare (ProHealth'07)

    NARCIS (Netherlands)

    Reichert, M.U.; Peleg, M.; Lenz, R.

    2007-01-01

    These pre-proceedings contain the presentations given at the 1st Int'l Workshop on Process-oriented Information Systems in Healthcare (ProHealth'07). Formal proceedings will be published in Springer's LNCS series. Process-oriented information systems have been demanded for more than 20 years and t

  1. Pre-Proceedings of the 1st International Workshop on Process-oriented Information Systems in Healthcare (ProHealth'07)

    NARCIS (Netherlands)

    Reichert, M.U.; Peleg, M.; Lenz, R.

    2007-01-01

    These pre-proceedings contain the presentations given at the 1st Int'l Workshop on Process-oriented Information Systems in Healthcare (ProHealth'07). Formal proceedings will be published in Springer's LNCS series. Process-oriented information systems have been demanded for more than 20 years and ter

  2. Echo-planar magnetic resonance imaging (EPI) with high-resolution matrix in intra-axial brain tumors

    Energy Technology Data Exchange (ETDEWEB)

    Bruening, R.; Scheidler, J.; Porn, U.; Reiser, M. [Institute of Diagnostic Radiology, Klinikum Grosshadern, University of Munich (Germany); Seelos, K.; Yousry, T. [Department of Neuroradiology, Institute of Diagnostic Radiology, Klinikum Grosshadern, University of Munich (Germany); Exner, H. [Institute for Medical Epidemiology, Klinikum Grosshadern, University of Munich, Munich (Germany); Rosen, B.R. [Department of Radiology, Massachusetts General Hospital, NMR Center, Charlestown, MA (United States)

    1999-09-01

    The aim of this study was to assess the potential of high-speed interleaved echo-planar imaging (EPI) to achieve diagnostic image quality comparable to T2-weighted imaging in patients with brain tumors. Seventeen patients with intra-axial, supratentorial tumors (10 untreated gliomas, 7 radiated gliomas) were investigated on a 1.5-T scanner. The conventional scan (SE, TR/TE = 2200/80 ms, 18 slices) was acquired in 8 min, 4 s, and EPI (TR/TE = 3000/80 ms, 18 slices) was completed in 25 s. The films were compared in a blinded trail by three radiologists. On the general impression and anatomic display, both sequences were rated to be of similar quality. Artifacts were slightly more pronounced at the skull base and around surgical clips using EPI. Tumor delineation was nearly equivalent using EPI, compared with the T2-weighted sequence. Echo-planar imaging reached diagnostic quality in all patients. Interleaved high-resolution EPI yielded sufficient quality to depict intra-axial, supratentorial brain tumors. Since EPI can be obtained in a small fraction of the time needed for conventional spin echo, in addition to other indications it could be considered to study patients unable to cooperate. (orig.) With 3 figs., 3 tabs., 27 refs.

  3. Stress and mental health problems in 1st year medical students: a survey of two medical colleges in Kanpur, India

    Directory of Open Access Journals (Sweden)

    Shivendra Jena

    2015-01-01

    Full Text Available Background: Incidence of stress among medical students has been reported to be between high and very high. Medical students in pre-clinical phase are more likely to develop psychological distress than medical students in clinical phase. It may affect academic performance and lead to anxiety, depression and substance abuse. Methods: First year students of one government medical college and one private medical college of Kanpur, Uttar Pradesh, India, were surveyed to find out stress and mental health problems shortly after their admission. Results: The two colleges showed difference in the frequencies of a number of factors- current stress, sleep problem, sad mood, both parents working, parents giving sufficient time, non-participation in extra-curricular activities, sharing problem with their families, having break-up in a romantic relationship and poor relationships with classmates and roommate. More students of the government medical college reported to have current stress compared to the students of the private medical college. While all students of the government medical who had stress since admission did not recover from it, 55.56% of students of the private medical college recovered from it at the time of our survey. Conclusion: a Psychiatry Department of every medical college should be involved in screening 1st year students having stress and mental health problems and managing them. b Medical education should be imparted in more relaxed and fun filled manner to help students cope with the long and difficult course. [Int J Res Med Sci 2015; 3(1.000: 130-134

  4. Evaluation of neutron irradiation embrittlement in the Korean reactor pressure vessel steels(I) (1st progress report)

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Jun Hwa; Lee, Bong Sang; Park, Duck Gun; Byun, Tak Sang; Kim, Joo Hag; Oh, Yong Jun; Yoon, Ji Hyun; Chi, Sei Hwan; Kuk, Il Hyun [Korea Atomic Energy Research Institute, Taejon (Korea)

    1998-10-01

    The SA508-3 reactor pressure vessel materials degrade due to the application at high temperature, high pressure, and neutron irradiation. In the present study it is planned to examine the effects of neutron irradiation on the properties for assessing the integrity of domestic reactors. The key tests are the Charpy impact test, tensile test, static and dynamic fracture toughness test, J-R test. The additional tests for obtaining basic material properties, such as micro-hardness, microstructural properties, small punch energy etc., are also performed. The irradiation tests are being performed at HANARO of KAERI through the instrumented capsules designed by KAERI and the post-irradiation tests are being performed at IMEF(Irradiated Material Evaluation Facility) of material (UCN-4), Si+Al (YGN-5), UCN-4 weld metal, and UCN-4 HAZ. In the irradiation test the temperature should be controlled in the range of 290 {+-} 10 deg C and the test materials would be irradiated to 2 to 3 neutron fluence levels including the end-of-life fluence. The status of performing this project is that (1) the key data on mechanical properties, mainly related to the fracture toughness, of the unirradiated materials have been obtained, (2) the irradiation of the 1st instrumented capsule, a preliminary test capsule containing miniature specimens, has been completed and is being stored for testing in IMEF, and (3) the 2nd instrumented capsule is being manufactured and will be irradiated in the beginning or 1999. This report includes mainly the experimental methods and results. The status of the design and manufacturing of the instrumented capsules and specimens was also briefly described. (author). 13 refs., 15 figs., 10 tabs.

  5. Residual effects of TMOF-Bti formulations against 1 st instar Aedes aegypti Linnaeus larvae outside laboratory

    Institute of Scientific and Technical Information of China (English)

    Saiful AN; Lau MS; Sulaiman S; Hidayatulfathi O

    2012-01-01

    Objective: To evaluate the effectiveness and residual effects of trypsin modulating oostatic factor-Bacillus thuringiensis israeliensis (TMOF-Bti) formulations against Aedes aegypti (Ae. aegypti) (L.) larvae at UKM Campus Kuala Lumpur. Methods: Twenty first instar Ae. aegypti larvae were added in each bucket containing 4 L of water supplied with crushed dried leaf powder as their source of food. Combination of TMOF-Bti in rice husk formulation with the following weights viz 10, 25, 50 and 100 mg, respectively in duplicate was distributed in the buckets; while TMOF-Bti in wettable powder formulation each weighing viz 2, 5, 10 and 20 mg, respectively in duplicate was also placed in the buckets. The control buckets run in duplicate with 4 L of water and 20 first instar Ae. aegypti larvae. All buckets were covered with mosquito netting. Larval mortality was recorded after 24 hours and weekly for five weeks. A new batch of 20 1st instar larvaeAe. aegypti was introduced into each bucket weekly without additional TMOF-Bti rice husk formulation or wettable powder. The experiment was repeated for four times. Results: The result of the study showed that all formulations were very effective on the first two weeks by giving 100%larval mortality for all concentrations applied. The TMOF (2%) + Bti (2%) had a good residual effect until the end of 3rd week, TMOF (4%) + Bti (4%) until 4th week, wettable powder TMOF (20%) + Bti (20%) until the third week. Conclusions: From the results it can be concluded that the TMOF-Bti formulations can be utilized in dengue vector control.

  6. In vitro skin irritation testing: Improving the sensitivity of the EpiDerm skin irritation test protocol.

    Science.gov (United States)

    Kandárová, Helena; Hayden, Patrick; Klausner, Mitch; Kubilus, Joseph; Kearney, Paul; Sheasgreen, John

    2009-12-01

    A skin irritation test (SIT) utilising a common protocol for two in vitro reconstructed human epidermal (RhE) models, EPISKIN and EpiDerm, was developed, optimised and evaluated as a replacement for the in vivo rabbit skin irritation test in an ECVAM-sponsored validation study. In 2007, both RhE models were recognised by an independent peer-review panel and the ECVAM Scientific Advisory Committee (ESAC) as validated for use with the common SIT protocol. The EPISKIN SIT was endorsed as a full replacement of the in vivo rabbit test. Since the EpiDerm SIT proved to be less sensitive than the in vivo test and the EPISKIN SIT, the test was recognised as a validated component of a tiered testing strategy, in which positive results are accepted and negative results require further confirmation. The ESAC, in its April 2007 statement, also recommended increasing the sensitivity of the EpiDerm SIT, in order to gain the full acceptance. Analysis of the EpiDerm and EPISKIN data from the ECVAM validation study indicated that the lower sensitivity of the EpiDerm SIT might be linked to the more robust barrier properties of the EpiDerm model. This hypothesis was also in line with results published previously. To overcome the relatively low sensitivity of the EpiDerm protocol as a hindrance to full regulatory acceptance, a modification of exposure conditions was introduced into the protocol to achieve better agreement with the in vivo rabbit data. In the Modified EpiDerm SIT protocol, the test chemical exposure time was increased from 15 minutes to 60 minutes. In addition, part of the exposure was performed at 37 degrees C. When the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) viability assay endpoint was used for classification, a significant increase of sensitivity was obtained (86.1%), whilst maintaining the high specificity of the method (76.3%). With the change to the EU classification system, which now uses higher cut-off for the classification of

  7. Plant collecting program in Southeast Asia under the sponsorship of the United States National Cancer Institute (NCI) (1986-1991)

    NARCIS (Netherlands)

    Soejarto, D.D.

    1992-01-01

    Under the funding from the United States National Cancer Institute (NCI)¹, a program was undertaken to collect plant samples in Southeast Asia to be tested for their cancer- and AIDS-arresting properties, for the period of September 1, 1986 through August 31, 1991. The program was implemented with

  8. Paternal postpartum mood: bipolar episodes? Depressão paterna: episódio bipolar?

    Directory of Open Access Journals (Sweden)

    Karen Amaral Tavares Pinheiro

    2011-09-01

    Full Text Available OBJECTIVE: We describe the prevalence of depressive and bipolar spectrum episodes in fathers in antenatal and postnatal periods, as well as at 12 months after childbirth. METHOD: A longitudinal follow-up study was conducted with a representative sample of 739 fathers whose children were born between April 2007 and May 2008 in maternity wards in the city of Pelotas, southern Brazil. Paternal psychopathology was measured with the Mini Neuropsychiatric Interview (MINI across three time points: between 28 and 34 weeks of pregnancy (T1, 30 to 60 days postpartum (T2, and 12 months after childbirth (T3. RESULTS: The prevalence of depressive episodes was 5.0% at T1, 4.5% at T2, and 4.3% at T3. Mixed episodes were present in 3%, 1.7%, and 0.9% of subjects, respectively, and accounted for 61.1% of the cases of depression in the antenatal period, 37.5% in postpartum, and 21.4% at 12 months. Depressive and manic/hypomanic episodes were significantly associated during pregnancy and in postpartum, but not at 12 months after childbirth. CONCLUSION: Bipolar episodes were common in men with depressive symptoms during their partner's pregnancy in the postpartum period and, to a lesser extent, 12 months after childbirth. Therefore, this population should be carefully investigated for manic and hypomanic symptoms.OBJETIVO: Verificar a prevalência dos episódios depressivos e bipolares em homens no período pré e pós-natal, assim como 12 meses após o parto. MÉTODO: Estudo longitudinal com amostra de pais cujas crianças nasceram entre abril de 2007 e maio de 2008 em maternidades da cidade de Pelotas-RS, no sul do Brasil. Episódios depressivos e maníacos/hipomaníacos foram mensurados com o Mini Neuropsychiatric Interview em três tempos diferentes: entre a 28ª e 34ª semanas de gestação (T1, 30 a 60 dias após o parto (T2 e 12 meses após o nascimento da criança. RESULTADOS: A prevalência de episódios depressivos foi 5,0% em T1, 4,5% em T2 e 4,3% em T3

  9. Paternal postpartum mood: bipolar episodes? Depressão paterna: episódio bipolar?

    Directory of Open Access Journals (Sweden)

    Karen Amaral Tavares Pinheiro

    2011-01-01

    Full Text Available OBJECTIVE: We describe the prevalence of depressive and bipolar spectrum episodes in fathers in antenatal and postnatal periods, as well as at 12 months after childbirth. METHOD: A longitudinal follow-up study was conducted with a representative sample of 739 fathers whose children were born between April 2007 and May 2008 in maternity wards in the city of Pelotas, southern Brazil. Paternal psychopathology was measured with the Mini Neuropsychiatric Interview (MINI across three time points: between 28 and 34 weeks of pregnancy (T1, 30 to 60 days postpartum (T2, and 12 months after childbirth (T3. RESULTS: The prevalence of depressive episodes was 5.0% at T1, 4.5% at T2, and 4.3% at T3. Mixed episodes were present in 3%, 1.7%, and 0.9% of subjects, respectively, and accounted for 61.1% of the cases of depression in the antenatal period, 37.5% in postpartum, and 21.4% at 12 months. Depressive and manic/hypomanic episodes were significantly associated during pregnancy and in postpartum, but not at 12 months after childbirth. CONCLUSION: Bipolar episodes were common in men with depressive symptoms during their partner's pregnancy in the postpartum period and, to a lesser extent, 12 months after childbirth. Therefore, this population should be carefully investigated for manic and hypomanic symptoms.OBJETIVO: Verificar a prevalência dos episódios depressivos e bipolares em homens no período pré e pós-natal, assim como 12 meses após o parto. MÉTODO: Estudo longitudinal com amostra de pais cujas crianças nasceram entre abril de 2007 e maio de 2008 em maternidades da cidade de Pelotas-RS, no sul do Brasil. Episódios depressivos e maníacos/hipomaníacos foram mensurados com o Mini Neuropsychiatric Interview em três tempos diferentes: entre a 28ª e 34ª semanas de gestação (T1, 30 a 60 dias após o parto (T2 e 12 meses após o nascimento da criança. RESULTADOS: A prevalência de episódios depressivos foi 5,0% em T1, 4,5% em T2 e 4,3% em T3

  10. New NCI-N87-derived human gastric epithelial line after human telomerase catalytic subunit over-expression

    Science.gov (United States)

    Saraiva-Pava, Kathy; Navabi, Nazanin; Skoog, Emma C; Lindén, Sara K; Oleastro, Mónica; Roxo-Rosa, Mónica

    2015-01-01

    AIM: To establish a cellular model correctly mimicking the gastric epithelium to overcome the limitation in the study of Helicobacter pylori (H. pylori) infection. METHODS: Aiming to overcome this limitation, clones of the heterogenic cancer-derived NCI-N87 cell line were isolated, by stably-transducing it with the human telomerase reverse-transcriptase (hTERT) catalytic subunit gene. The clones were first characterized regarding their cell growth pattern and phenotype. For that we measured the clones’ adherence properties, expression of cell-cell junctions’ markers (ZO-1 and E-cadherin) and ability to generate a sustained transepithelial electrical resistance. The gastric properties of the clones, concerning expression of mucins, zymogens and glycan contents, were then evaluated by haematoxylin and eosin staining, Periodic acid Schiff (PAS) and PAS/Alcian Blue-staining, immunocytochemistry and Western blot. In addition, we assessed the usefulness of the hTERT-expressing gastric cell line for H. pylori research, by performing co-culture assays and measuring the IL-8 secretion, by ELISA, upon infection with two H. pylori strains differing in virulence. RESULTS: Compared with the parental cell line, the most promising NCI-hTERT-derived clones (CL5 and CL6) were composed of cells with homogenous phenotype, presented higher relative telomerase activities, better adhesion properties, ability to be maintained in culture for longer periods after confluency, and were more efficient in PAS-reactive mucins secretion. Both clones were shown to produce high amounts of MUC1, MUC2 and MUC13. NCI-hTERT-CL5 mucins were shown to be decorated with blood group H type 2 (BG-H), Lewis-x (Lex), Ley and Lea and, in a less extent, with BG-A antigens, but the former two antigens were not detected in the NCI-hTERT-CL6. None of the clones exhibited detectable levels of MUC6 nor sialylated Lex and Lea glycans. Entailing good gastric properties, both NCI-hTERT-clones were found to produce

  11. NCI's High Performance Computing (HPC) and High Performance Data (HPD) Computing Platform for Environmental and Earth System Data Science

    Science.gov (United States)

    Evans, Ben; Allen, Chris; Antony, Joseph; Bastrakova, Irina; Gohar, Kashif; Porter, David; Pugh, Tim; Santana, Fabiana; Smillie, Jon; Trenham, Claire; Wang, Jingbo; Wyborn, Lesley

    2015-04-01

    The National Computational Infrastructure (NCI) has established a powerful and flexible in-situ petascale computational environment to enable both high performance computing and Data-intensive Science across a wide spectrum of national environmental and earth science data collections - in particular climate, observational data and geoscientific assets. This paper examines 1) the computational environments that supports the modelling and data processing pipelines, 2) the analysis environments and methods to support data analysis, and 3) the progress so far to harmonise the underlying data collections for future interdisciplinary research across these large volume data collections. NCI has established 10+ PBytes of major national and international data collections from both the government and research sectors based on six themes: 1) weather, climate, and earth system science model simulations, 2) marine and earth observations, 3) geosciences, 4) terrestrial ecosystems, 5) water and hydrology, and 6) astronomy, social and biosciences. Collectively they span the lithosphere, crust, biosphere, hydrosphere, troposphere, and stratosphere. The data is largely sourced from NCI's partners (which include the custodians of many of the major Australian national-scale scientific collections), leading research communities, and collaborating overseas organisations. New infrastructures created at NCI mean the data collections are now accessible within an integrated High Performance Computing and Data (HPC-HPD) environment - a 1.2 PFlop supercomputer (Raijin), a HPC class 3000 core OpenStack cloud system and several highly connected large-scale high-bandwidth Lustre filesystems. The hardware was designed at inception to ensure that it would allow the layered software environment to flexibly accommodate the advancement of future data science. New approaches to software technology and data models have also had to be developed to enable access to these large and exponentially

  12. (Updated) NCI Fiscal 2016 Bypass Budget Proposes $25 Million for Frederick National Lab | Poster

    Science.gov (United States)

    By Nancy Parrish, Staff Writer; image by Richard Frederickson, Staff Photographer The additional funding requested for Frederick National Laboratory for Cancer Research (FNLCR) in the Fiscal 2016 Bypass Budget was $25 million, or approximately 3.5 percent of the total additional funding request of $715 million. Officially called the Professional Judgment Budget, the Bypass Budget is a result of the National Cancer Act of 1971, which authorizes NCI to submit a budget directly to the president, to send to Congress. With a focus on NCI’s research priorities and areas of cancer research with potential for investment, the Bypass Budget specifies additional funding, over and above the current budget, that is needed to advance

  13. AACR-NCI-EORTC--21st International Symposium. Molecular targets and cancer therapeutics--Part 2.

    Science.gov (United States)

    Walker, Karen; Padhiar, Meenal

    2010-01-01

    The 21st international symposium of the American Association for Cancer Research (AACR), the NCI and the European Organization for Research and Treatment of Cancer (EORTC), held in Boston, included topics covering the development of therapeutics and molecular targets in the field of cancer research. This conference report highlights selected presentations on the development of novel drugs for cancer. Investigational drugs discussed include RO-506876 (F Hoffmann-La Roche Ltd), GDC-0980 (Genentech Inc), EMD-1214063 and EMD-1204831 (Merck Serono SA), AR-mTOR01 and AR-mTOR-26 (Array BioPharma Inc), GSK-2126458 (GlaxoSmithKline plc), EXEL-1415 and EXEL-2008 (Exelixis Inc), FP-1039 (FivePrime Therapeutics Inc), and AV-412 (AVEO Pharmaceuticals Inc).

  14. (Updated) NCI Fiscal 2016 Bypass Budget Proposes $25 Million for Frederick National Lab | Poster

    Science.gov (United States)

    By Nancy Parrish, Staff Writer; image by Richard Frederickson, Staff Photographer The additional funding requested for Frederick National Laboratory for Cancer Research (FNLCR) in the Fiscal 2016 Bypass Budget was $25 million, or approximately 3.5 percent of the total additional funding request of $715 million. Officially called the Professional Judgment Budget, the Bypass Budget is a result of the National Cancer Act of 1971, which authorizes NCI to submit a budget directly to the president, to send to Congress. With a focus on NCI’s research priorities and areas of cancer research with potential for investment, the Bypass Budget specifies additional funding, over and above the current budget, that is needed to advance

  15. Transmission of epi-alleles with MET1-dependent dense methylation in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Michael Watson

    Full Text Available DNA methylation in plants targets cytosines in three sequence contexts, CG, CHG and CHH (H representing A, C or T. Each of these patterns has traditionally been associated with distinct DNA methylation pathways with CHH methylation being controlled by the RNA dependent DNA methylation (RdDM pathway employing small RNAs as a guide for the de novo DOMAINS REARRANGED METHYLTRANSFERASE (DRM2, and maintenance DNA METHYLTRANSFERASE1 (MET1 being responsible for faithful propagation of CG methylation. Here we report an unusual 'dense methylation' pattern under the control of MET1, with methylation in all three sequence contexts. We identified epi-alleles of dense methylation at a non coding RNA locus (At4g15242 in Arabidopsis ecotypes, with distinct dense methylation and expression characteristics, which are stably maintained and transmitted in genetic crosses and which can be heritably altered by depletion of MET1. This suggests that, in addition to its classical CG maintenance function, at certain loci MET1 plays a role in creating transcriptional diversity based on the generation of independent epi-alleles. Database inspection identified several other loci with MET1-dependent dense methylation patterns. Arabidopsis ecotypes contain distinct epi-alleles of these loci with expression patterns that inversely correlate with methylation density, predominantly within the transcribed region. In Arabidopsis, dense methylation appears to be an exception as it is only found at a small number of loci. Its presence does, however, highlight the potential for MET1 as a contributor to epigenetic diversity, and it will be interesting to investigate the representation of dense methylation in other plant species.

  16. Fast, Accurate and Automatic Ancient Nucleosome and Methylation Maps with epiPALEOMIX.

    Science.gov (United States)

    Hanghøj, Kristian; Seguin-Orlando, Andaine; Schubert, Mikkel; Madsen, Tobias; Pedersen, Jakob Skou; Willerslev, Eske; Orlando, Ludovic

    2016-12-01

    The first epigenomes from archaic hominins (AH) and ancient anatomically modern humans (AMH) have recently been characterized, based, however, on a limited number of samples. The extent to which ancient genome-wide epigenetic landscapes can be reconstructed thus remains contentious. Here, we present epiPALEOMIX, an open-source and user-friendly pipeline that exploits post-mortem DNA degradation patterns to reconstruct ancient methylomes and nucleosome maps from shotgun and/or capture-enrichment data. Applying epiPALEOMIX to the sequence data underlying 35 ancient genomes including AMH, AH, equids and aurochs, we investigate the temporal, geographical and preservation range of ancient epigenetic signatures. We first assess the quality of inferred ancient epigenetic signatures within well-characterized genomic regions. We find that tissue-specific methylation signatures can be obtained across a wider range of DNA preparation types than previously thought, including when no particular experimental procedures have been used to remove deaminated cytosines prior to sequencing. We identify a large subset of samples for which DNA associated with nucleosomes is protected from post-mortem degradation, and nucleosome positioning patterns can be reconstructed. Finally, we describe parameters and conditions such as DNA damage levels and sequencing depth that limit the preservation of epigenetic signatures in ancient samples. When such conditions are met, we propose that epigenetic profiles of CTCF binding regions can be used to help data authentication. Our work, including epiPALEOMIX, opens for further investigations of ancient epigenomes through time especially aimed at tracking possible epigenetic changes during major evolutionary, environmental, socioeconomic, and cultural shifts.

  17. Delivery of epidermal neural crest stem cells (EPI-NCSC) to hippocamp in Alzheimer's disease rat model.

    Science.gov (United States)

    Esmaeilzade, Banafshe; Nobakht, Maliheh; Joghataei, Mohammad Taghi; Rahbar Roshandel, Nahid; Rasouli, Homa; Samadi Kuchaksaraei, Ali; Hosseini, Seyed Mohammad; Najafzade, Nowruz; Asalgoo, Sara; Hejazian, Leila Beygom; Moghani Ghoroghi, Fatima

    2012-01-01

    Alzheimer's disease (AD) is characterized by progressive neuronal loss in hippocamp. Epidermal neural crest stem cells (EPI-NCSC) can differentiate into neurons, astrocytes and oligodendrocytes. The purpose of this study was to evaluate the effects of transplanting EPI-NCSC into AD rat model. Two weeks after induction of AD by injection of Amyloid-β1-40 into CA1 area of rat hippocamp, Y-maze and single-trial passive avoidance tests were used to show deficit of learning and memory abilities. EPI-NCSC were obtained from the vibrissa hair follicle of rat, cultured and labeled with bromodeoxyuridine. When Alzheimer was proved by behavioral tests, EPI-NCSC was transplanted into CA3 area of hippocamp in AD rat model. The staining of EPI-NCSC markers (nestin and SOX10) was done in vitro. Double-labeling immunofluorescence was performed to study survival and differentiation of the grafted cells. We showed that transplanted EPI-NCSC survive and produce many neurons and a few glial cells, presenting glial fibrillary acidic protein. Total number of granule cells in hippocamp was estimated to be more in the AD rat model with transplanted cells as compared to AD control group. We observed that rats with hippocampal damage made more errors than control rats on the Y-maze, when reward locations were reversed. Transplanted cells were migrated to all areas of hippocamp and the total number of granule cell in treatment group was equal compared to control group. Transplantation of EPI-NCSC into hippocamp might differentiate into cholinergic neurons and could cure impairment of memory in AD rat model.

  18. Simulation and assessment of bioinspired visual processing system for epi-retinal prostheses.

    Science.gov (United States)

    Vurro, Milena; Baselli, Giuseppe; Orabona, Francesco; Sandini, Giulio

    2006-01-01

    Retinal prosthesis represents the best near-term hope for individuals with chronic blinding disease of the outer retina. However the small number of stimulating electrodes produces a poor, low resolution image. We propose a new preprocessing method for epi-retinal implants and validate it through a novel simulation of the implanted blind perception. Twenty-one normally sighted, untrained subjects performed a face recognition test. Three different electrodes grids were simulated: rectangular, hexagonal and log-polar. The results show that the proposed pre-processing method has a good and statistically significant performance improvement.

  19. Primeiro episódio da esquizofrenia e assistência de enfermagem

    OpenAIRE

    Giacon,Bianca Cristina Ciccone; Galera,Sueli Aparecida Frari

    2006-01-01

    A esquizofrenia é um dos principais problemas de saúde da atualidade, exigindo considerável investimento do sistema de saúde. A intervenção no primeiro episódio do transtorno oferece uma oportunidade única no tratamento da esquizofrenia, influenciando no curso da doença. O presente artigo consiste em uma revisão crítica de literatura cujos objetivos são examinar o conhecimento sobre o primeiro surto de esquizofrenia e discutir a contribuição da enfermagem na assistência. Foi utilizada pesquis...

  20. The Pocketscope: a spatial light modulator based epi-fluorescence microscope for optogenetics

    Science.gov (United States)

    Linnenberger, Anna; Peterka, Darcy S.; Quirin, Sean; Yuste, Rafael

    2014-09-01

    Microscopy incorporating spatial light modulators (SLMs) enables three dimensional (3D) excitation and monitoring of the activity of neuronal ensembles, enabling studies of neuronal circuit activity both in vitro and in vivo. In this paper we present a portable (22 cm x 42.5 cm x 30 cm), SLM-based epi-fluorescence upright microscope ("Pocketscope") that enables 3D calcium imaging and photoactivation of neurons in brain slices. Here we describe the implementation of the instrument; quantify the volume over which neural activity can be excited; and demonstrate the use of the system for mapping neural circuits in brain slices.

  1. Effects of emodin on gene expression profile in small cell lung cancer NCI-H446 cells

    Institute of Scientific and Technical Information of China (English)

    FU Zhong-yan; HAN Jin-xiang; HUANG Hai-yan

    2007-01-01

    Background The treatment of patients with small cell lung cancer (SCLC) is based on chemotherapy. However, the treatment is limited by the development of drug resistance. Emodin has been shown to exhibit an anti-cancer effect. But the molecular mechanism remains unclear. This study was conducted to investigate the effect of emodin on the gene expression profile changes in SCLC NCI-H446 cells.Methods NCI-H446 cells were treated with emodin and cell viability was determined by MTT assay. Cell apoptosis was determined by both flow cytometry and caspase-3 activity assay. The effect of emodin on the gene expression profile of NCI-H446 cells was analyzed using cDNA microarray. Semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) was used to validate the microarray results.Results Emodin suppressed viability, induced apoptosis and changed cell cycle of NCI-H446 cells. Among the 1262 genes, 10 genes were up-regulated and 8 genes were down-regulated more than 2 folds in NCI-H446 cells when compared with the control cells after treatment with emodin for 12 hours, while 12 genes were up-regulated and 24 genes were down-regulated after treatment with emodin for 24 hours. These genes were involved in metabolism, signal transduction, transcription regulation, cytoskeleton organization, immune response, transport, protein synthesis, cell cycle control, cell adhesion and RNA processing. The RT-PCR results were consistent with those obtained by the microarray.Conclusions Emodin affects the expression of genes involved in various cellular functions and plays important roles in cell apoptosis, tumor metastasis and chemotherapy-resistance, which suggests emodin might become an effective chemopreventive or chemotherapeutic agent for SCLC.

  2. Creating Research-Rich Learning Experiences and Quantitative Skills in a 1st Year Earth Systems Course

    Science.gov (United States)

    King, P. L.; Eggins, S.; Jones, S.

    2014-12-01

    We are creating a 1st year Earth Systems course at the Australian National University that is built around research-rich learning experiences and quantitative skills. The course has top students including ≤20% indigenous/foreign students; nonetheless, students' backgrounds in math and science vary considerably posing challenges for learning. We are addressing this issue and aiming to improve knowledge retention and deep learning by changing our teaching approach. In 2013-2014, we modified the weekly course structure to a 1hr lecture; a 2hr workshop with hands-on activities; a 2hr lab; an assessment piece covering all face-to-face activities; and a 1hr tutorial. Our new approach was aimed at: 1) building student confidence with data analysis and quantitative skills through increasingly difficult tasks in science, math, physics, chemistry, climate science and biology; 2) creating effective learning groups using name tags and a classroom with 8-person tiered tables; 3) requiring students to apply new knowledge to new situations in group activities, two 1-day field trips and assessment items; 4) using pre-lab and pre-workshop exercises to promote prior engagement with key concepts; 5) adding open-ended experiments to foster structured 'scientific play' or enquiry and creativity; and 6) aligning the assessment with the learning outcomes and ensuring that it contains authentic and challenging southern hemisphere problems. Students were asked to design their own ocean current experiment in the lab and we were astounded by their ingenuity: they simulated the ocean currents off Antarctica; varied water density to verify an equation; and examined the effect of wind and seafloor topography on currents. To evaluate changes in student learning, we conducted surveys in 2013 and 2014. In 2014, we found higher levels of student engagement with the course: >~80% attendance rates and >~70% satisfaction (20% neutral). The 2014 cohort felt that they were more competent in writing

  3. PREFACE: 1st International School and Conference "Saint Petersburg OPEN 2014" on Optoelectronics, Photonics, Engineering and Nanostructures

    Science.gov (United States)

    2014-09-01

    Dear Colleagues, 1st International School and Conference "Saint Petersburg OPEN 2014" on Optoelectronics, Photonics, Engineering and Nanostructures was held on March 25 - 27, 2014 at St. Petersburg Academic University - Nanotechnology Research and Education Centre of the Russian Academy of Sciences. The School and Conference included a series of invited talks given by leading professors with the aim to introduce young scientists with actual problems and major advances in physics and technology. The keynote speakers were: Mikhail Glazov (Ioffe Physico-Technical Institute RAS, Russia) Vladimir Dubrovskii (Saint Petersburg Academic University RAS, Russia) Alexey Kavokin (University of Southampton, United Kingdom and St. Petersburg State University, Russia) Vladimir Korenev (Ioffe Physico-Technical Institute RAS, Russia) Sergey Kukushkin (Institute of Problems of Mechanical Engineering RAS, Russia) Nikita Pikhtin (Ioffe Physico-Technical Institute RAS, Russia and "Elfolum" Ltd., Russia) Dmitry Firsov (Saint Petersburg State Polytechnical University, Russia) During the poster session all undergraduate and graduate students attending the conference presented their works. Sufficiently large number of participants with more than 160 student attendees from all over the world allowed the Conference to provide a fertile ground for the fruitful discussions between the young scientists as well as to become a perfect platform for the valuable discussions between student authors and highly experienced scientists. The best student papers, which were selected by the Program Committee and by the invited speakers basing on the theses and their poster presentation, were awarded with diplomas of the conference - see the photos. This year's School and Conference is supported by SPIE (The International Society for Optics and Photonics), OSA (The Optical Society), St. Petersburg State Polytechnical University and by Skolkovo Foundation. It is a continuation of the annual schools and

  4. Difference between CKD-EPI and MDRD equations in calculating glomerular filtration rate in patients with cirrhosis

    Institute of Scientific and Technical Information of China (English)

    Yu-Wei Chen; Han-Hsiang Chen; Tsang-En Wang; Ching-Wei Chang; Chen-Wang Chang; Chih-Jen Wu

    2011-01-01

    AIM: To evaluate the difference between the performance of the (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations in cirrhotic patients. METHODS: From Jan 2004 to Oct 2008, 4127 cirrhotic patients were reviewed. Patients with incomplete data with respect to renal function were excluded; thus, a total of 3791 patients were included in the study. The glomerular filtration rate (GFR) was estimated by the 4-variable MDRD (MDRD-4), 6-variable MDRD (MDRD-6), and CKD-EPI equations. RESULTS: When serum creatinine was 0.7-6.8 mg/dL and 0.6-5.3 mg/dL in men and women, respectively, a significantly lower GFR was estimated by the MDRD-6 than by the CKD-EPI. Similar GFRs were calculated by both equations when creatinine was > 6.9 mg/dL and > 5.4 mg/dL in men and women, respectively. In predicting in-hospital mortality, estimated GFR obtained by the MDRD-6 showed better accuracy [81.72%; 95% confidence interval (CI), 0.94-0.95] than that obtained by the MDRD-4 (80.22%; 95%CI, 0.96-0.97), CKD-EPI (79.93%; 95%CI, 0.96-0.96), and creatinine (77.50%; 95%CI, 2.27-2.63). CONCLUSION: GFR calculated by the 6-variable MDRD equation may be closer to the true GFR than that calculated by the CKD-EPI equation.

  5. 1st Guidelines of the Brazilian Society of Cardiology on processes and skills for education in cardiology in Brazil--executive summary.

    Science.gov (United States)

    Sousa, Marcos Roberto de; Mourilhe-Rocha, Ricardo; Paola, Angelo Amato Vincenzo de; Köhler, Ilmar; Feitosa, Gilson Soares; Schneider, Jamil Cherem; Feitosa-Filho, Gilson Soares; Nicolau, José Carlos; Ferreira, João Fernando Monteiro; Morais, Nelson Siqueira de

    2012-02-01

    This article summarizes the "1st Guidelines of the Brazilian Society of Cardiology on Processes and Skills for Education in Cardiology in Brazil," which can be found in full at: . The guideline establishes the education time required in Internal Medicine and Cardiology with Specialization through theoretical and practical training. These requirements must be available at the center forming Specialists in Cardiology and the Cardiology contents.

  6. The 1st European Summer School on 'proteomic basics'--the students view. 12-18 August, 2007 Kloster Neustift, Brixen/Bressanone, South Tyrol, Italy.

    Science.gov (United States)

    Collins, Emily S; Little, Samantha J

    2008-01-01

    Fifty postgraduate and postdoctoral delegates from all over Europe attended the week-long '1st European Summer School on Proteomic Basics' in Kloster Neustift in the Italian South Tyrol in August 2007. Invited proteomics experts gave tutorial lectures on Proteomics techniques with an emphasis on sample preparation, protein separation and purification in the first of an annual series of Proteomics Summer Schools funded by the EU and the Volkswagen Stiftung.

  7. Improving Students’ Vocabulary Through A Smartphone Application, Learn English With Music Songs: A Case Study Of The 1st Grade Students Of Sma Indonesia Membangun Medan

    OpenAIRE

    Nababan, Elysabeth

    2016-01-01

    This thesis entitled Improving Students’ Vocabulary through a Smartphone Application, Learn English with Music Songs: A Case Study 1st Grade Students of SMA Indonesia Membangun Medan. The aim of the study is to improve the students’ vocabulary through a smartphone application (Learn English with Music Songs). The students have difficulties in remembering new vocabulary and confused to understand the vocabulary. The students think that English is difficult and boring. To improve students’ voca...

  8. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015; Session “Brain & Development”

    OpenAIRE

    Various Authors

    2015-01-01

    Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN), European Society for Paediatric Research (ESPR), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI), with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT), supp...

  9. The analysis of the physical statement of cadets of the 1st course of the military Institute on the starting stage of studying

    Directory of Open Access Journals (Sweden)

    Ovcharuk I.S.

    2010-11-01

    Full Text Available The physical state of the youth which fulfills the rows of military forces of Ukraine has no tendency to improve according to the health and physical preparation. The physical state of cadets of the 1st course is analyzed. 69 cadets took part in research. It improves from the first month of being in educational establishment. Studying curriculum of this educational establishment must provide the fulfillment of all the tasks of physical preparation of military forces of Ukraine.

  10. 激素冲击疗法治疗Epi-LASIK术后haze的临床研究%Clinical observation of haze after Epi-LASIK operation by high-dose glucocorticoids

    Institute of Scientific and Technical Information of China (English)

    陆岩; 曹哲瑶; 夏丽坤

    2011-01-01

    目的:观察短期大剂量应用高浓度激素冲击疗法减轻或消除Epi-LASIK术后角膜上皮下雾状混浊(haze)的疗效.方法:选取Epi-LASIK术后双眼出现2~3级haze的患者16例32眼,右眼滴用1g/L氟米龙(氟美瞳)眼液冲击治疗,左眼非冲击治疗作为对比.结果:治疗3mo后,与左眼相比右眼haze减轻更显著,视力提高更明显.结论:氟美瞳冲击疗法治疗Epi-LASIK术后haze可缩短治疗时间,提高疗效,且并发症少,值得推广应用.

  11. MTA1-activated Epi-microRNA-22 regulates E-cadherin and prostate cancer invasiveness.

    Science.gov (United States)

    Dhar, Swati; Kumar, Avinash; Gomez, Christian R; Akhtar, Israh; Hancock, John C; Lage, Janice M; Pound, Charles R; Levenson, Anait S

    2017-03-01

    We have previously shown that metastasis-associated protein 1 (MTA1), a chromatin remodeler, plays an important role in prostate cancer invasiveness, likely through regulation of epithelial-to-mesenchymal transition. Here, we identified miR-22 as an epigenetic-microRNA (Epi-miR) directly induced by MTA1 and predicted to target E-cadherin. Loss-of-function and overexpression studies of MTA1 reinforced its regulatory role in miR-22 expression. MiR-22 directly targets the 3'-untranslated region of E-cadherin, and ectopic overexpression of miR-22 diminishes E-cadherin expression. Overexpression of miR-22 in prostate cancer cells promotes cell invasiveness and migration. Meta-analysis of patient tumor samples indicates a positive correlation between MTA1 and miR-22, supporting their inhibitory effect on E-cadherin expression. Our findings implicate the MTA1/Epi-miR-22/E-cadherin axis as a new epigenetic signaling pathway that promotes tumor invasion in prostate cancer. © 2017 Federation of European Biochemical Societies.

  12. A Simulation of the Effects of Receive Field Contrast on Motion-Corrected EPI Time Series

    CERN Document Server

    Sheltraw, D

    2012-01-01

    The receive field of MRI imparts an image contrast which is spatially fixed relative to the receive coil. If motion correction is used to correct subject motion occurring during an EPI time series then the receiver contrast will effectively move relative to the subject and produce temporal modulations in the image amplitude. This effect, which we will call the RFC-MoCo effect, may have consequences in the analysis and interpretation of fMRI results. There are many potential causes of motion-related noise and systematic error in EPI time series and isolating the RFC-MoCo effect would be difficult. Therefore, we have undertaken a simulation of this effect to better understand its severity. The simulations examine this effect for a receive-only single-channel 16-leg birdcage coil and a receive-only 12-channel phased array. In particular we study: (1) The effect size; (2) Its consequences to the temporal correlations between signals arising at different spatial locations (spatial-temporal correlations) as is ofte...

  13. Successful micronucleus testing with the EPI/001 3D reconstructed epidermis model: preliminary findings.

    Science.gov (United States)

    Andres, E; Molinari, J; Remoué, N; Sá-Rocha, V M; Barrichello, C; Hurtado, S P

    2012-03-18

    Currently, the cosmetics industry relies on the results of in vitro genotoxicity tests to assess the safety of chemicals. Although the cytokinesis-block micronucleus (CBMN) test for the detection of cells that have divided once is routinely used and currently accepted by regulatory agencies, it has some limitations. Reconstituted human epidermis (RHE) is widely used in safety assessments because its physiological properties resemble those of the skin, and because it allows testing of substances such as hydrophobic compounds. Thus, the micronucleus test is being adapted for application in RHE-reconstructed tissues. Here we investigated whether two different reconstructed epidermis models (EPI/001 from Straticell, and RHE/S/17 from Skinethic) are suitable for application of the micronucleus test. We found that acetone does not modify micronucleus frequency, cell viability, and model structure, compared with non-treated RHE. Treatment of the EPI/001 model with mitomycin C and vinblastine resulted in a dose-dependent increase of micronucleus frequency as well as a decrease of tissue viability and of binucleated cell rate, while no changes of the epidermal structure were observed. The number of binucleated cells obtained with the RHE/S/17 model was too small to permit micronucleus testing. These results indicate that the proliferative rate of the tissue used is a critical parameter in performing the micronucleus test on a 3D model.

  14. The rate of symptomatic improvement of congenital nasolacrimal duct obstruction in Japanese infants treated with conservative management during the 1st year of age

    Directory of Open Access Journals (Sweden)

    Hirohiko Kakizaki

    2008-06-01

    Full Text Available Hirohiko Kakizaki1, Yasuhiro Takahashi2, Shinsuke Kinoshita1, Kunihiko Shiraki2, Masayoshi Iwaki11Department of Ophthalmology, Aichi Medical University, Aichi, Japan; 2Department of Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, Osaka, JapanAbstract: This study aimed to examine the rate of symptomatic improvement of congenital nasolacrimal duct obstruction (CNLDO in Japanese infants treated with conservative management within the 1st year of age. Thirty-five lacrimal ducts in 27 patients diagnosed with CNLDO were included in the study. During the observational period, lacrimal ducts were massaged. As well, antibiotic eye drops, to be administered 4 times a day, were sometimes prescribed for obvious conjunctivitis. Two lacrimal ducts in 2 patients were probed before the 1st year of age because of dacryocystitis or severe blepharitis; these patients were included in the unimproved group. Twenty-nine lacrimal ducts in 21 patients resolved during the period (82.9%; with 16 lacrimal ducts resolving before six months of age. Therefore, a comparatively high percentage of resolution for CNLDO (82.9% following conservative management was shown before the 1st year of age in Japanese infants.Keywords: congenital nasolacrimal duct obstruction, symptomatic improvement, conservative management, massage, probing

  15. EVALUATION OF ANXIETY & DEPRESSIVE SYMPTOMS IN PATIENTS WITH 1 ST EPISODE OF CHEST PAIN ATTENDING MEDICINE OUT PATIENT DEPARTMENT OF TERTIARY CARE TEACHING HOSPITAL

    Directory of Open Access Journals (Sweden)

    Bhavik S.

    2015-06-01

    Full Text Available INTRODUCTION: As chest pain is an important symptom of coronary artery disease (CAD and other non - cardiac diseases , the presentation of the symptom often prompts referral to physicians for further investigation. Previous studies h ad shown significant as sociation between chest pain and D e pr e ssive and anxiety symptoms. AIMS AND OBJECTIVES: Evaluate and screen depressive symptoms , anxiety symptoms and somatic symptoms in patients with 1 st episode of chest pain attending medicine out - patient department of tertiary care teaching hospital. METHODOLGY : Cross - sectional observational study. Prior permission from institutional ethics committee of ‘SUMANDEEP VIDYAPEETH’ had been taken. 100 patients having first episosde of chest pain coming to M edicine opd of DHIRAJ HOSPITAL are recruited randomly after 1st December 2014. Each patient is given case r eport form containing sociodemographic data , patients medical history , depression and somatic symptoms scale and Hamilton’s anxiety scale (HAM - A. All data are entered in spss 16 and analysed with different ( S tatistical tests. Differences on categorical m easures will be reported as P value. The result is significant if P <0.05. RESULT: 38% & 49% patients have clinically significant depression and anxiety respectively. DSSS score is positively correlated with duration of chest pain. CONCLUSION : significant level of depression and anxiety found in 1 st episode of chest pain patients.

  16. Sampling strategies for subsampled segmented EPI PRF thermometry in MR guided high intensity focused ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    Odéen, Henrik, E-mail: h.odeen@gmail.com; Diakite, Mahamadou [Department of Physics and Astronomy, University of Utah, Salt Lake City, Utah 84108 and Department of Radiology, University of Utah, Salt Lake City, Utah 84108 (United States); Todd, Nick; Minalga, Emilee; Payne, Allison; Parker, Dennis L. [Department of Radiology, University of Utah, Salt Lake City, Utah 84108 (United States)

    2014-09-15

    Purpose: To investigate k-space subsampling strategies to achieve fast, large field-of-view (FOV) temperature monitoring using segmented echo planar imaging (EPI) proton resonance frequency shift thermometry for MR guided high intensity focused ultrasound (MRgHIFU) applications. Methods: Five different k-space sampling approaches were investigated, varying sample spacing (equally vs nonequally spaced within the echo train), sampling density (variable sampling density in zero, one, and two dimensions), and utilizing sequential or centric sampling. Three of the schemes utilized sequential sampling with the sampling density varied in zero, one, and two dimensions, to investigate sampling the k-space center more frequently. Two of the schemes utilized centric sampling to acquire the k-space center with a longer echo time for improved phase measurements, and vary the sampling density in zero and two dimensions, respectively. Phantom experiments and a theoretical point spread function analysis were performed to investigate their performance. Variable density sampling in zero and two dimensions was also implemented in a non-EPI GRE pulse sequence for comparison. All subsampled data were reconstructed with a previously described temporally constrained reconstruction (TCR) algorithm. Results: The accuracy of each sampling strategy in measuring the temperature rise in the HIFU focal spot was measured in terms of the root-mean-square-error (RMSE) compared to fully sampled “truth.” For the schemes utilizing sequential sampling, the accuracy was found to improve with the dimensionality of the variable density sampling, giving values of 0.65 °C, 0.49 °C, and 0.35 °C for density variation in zero, one, and two dimensions, respectively. The schemes utilizing centric sampling were found to underestimate the temperature rise, with RMSE values of 1.05 °C and 1.31 °C, for variable density sampling in zero and two dimensions, respectively. Similar subsampling schemes

  17. Improved quantification of 8-epi-prostaglandin F2 alpha and F2-isoprostanes by gas chromatography/triple-stage quadrupole mass spectrometry: partial cyclooxygenase-dependent formation of 8-epi-prostaglandin F2 alpha in humans.

    Science.gov (United States)

    Schweer, H; Watzer, B; Seyberth, H W; Nüsing, R M

    1997-12-01

    F2-isoprostanes are considered to be novel markers of lipid peroxidation. To study the in vivo formation of F2-isoprostanes, an improved method was developed for isotope dilution assays involving gas chromatography/triple-stage quadrupole mass spectrometry (GC/MS/MS) including thin-layer chromatography (TLC) (sum of all F2-isoprostanes) and high-performance liquid chromatographic (HPLC) purification (prostaglandin F2 alpha (PGF2 alpha) and 8-epi-PGF2 alpha). Following the addition of isotopically labeled prostaglandins to urine, the sample was acidified and applied to a C18 cartridge. After elution, prostaglandins were derivatized to pentafluorobenzyl esters and subjected to TLC. A broad zone was scratched off, isoprostanes were eluted and after formation of their trimethylsilyl ether derivatives the sum of F2-isoprostanes was determined by GC/MS/MS. For the determination of PGE2 alpha and 8-epi-PGF2 alpha prior to trimethylsilylation an additional HPLC step was performed and the fractions containing PGF2 alpha and 8-epi-PGF2 alpha were analyzed by GC/MS/MS. Using this technique, 8-epi-PGF2 alpha concentrations in urine samples as low as 5 pg ml-1 could be determined with high accuracy. The excretion rates of isoprostanes were studied in comparison with the classical prostaglandins in three different groups: healthy adults, healthy children and children with hyper-PGE syndrome (HPS), a pathological situation associated with a stimulated PGE2 synthesis. F2-isoprostanes represented the main arachidonic acid metabolites in these groups and 8-epi-PGF2 alpha excretion was comparable in its amount to the classical prostanoids. To delineate the cyclooxygenase-catalyzed contribution, the influence of indomethacin, an inhibitor of cyclooxygenases, on F2-isoprostane formation in healthy adults and in HPS children was analyzed. Significantly decreased excretion rates were observed 2 days after indomethacin administration for all prostanoids, including F2-isoprostanes and 8

  18. PREFACE: 1st Nano-IBCT Conference 2011 - Radiation Damage of Biomolecular Systems: Nanoscale Insights into Ion Beam Cancer Therapy

    Science.gov (United States)

    Huber, Bernd A.; Malot, Christiane; Domaracka, Alicja; Solov'yov, Andrey V.

    2012-07-01

    The 1st Nano-IBCT Conference entitled 'Radiation Damage in Biomolecular Systems: Nanoscale Insights into Ion Beam Cancer Therapy' was held in Caen, France, in October 2011. The Meeting was organised in the framework of the COST Action MP1002 (Nano-IBCT) which was launched in December 2010 (http://fias.uni-frankfurt.de/nano-ibct). This action aims to promote the understanding of mechanisms and processes underlying the radiation damage of biomolecular systems at the molecular and nanoscopic level and to use the findings to improve the strategy of Ion Beam Cancer Therapy. In the hope of achieving this, participants from different disciplines were invited to represent the fields of physics, biology, medicine and chemistry, and also included those from industry and the operators of hadron therapy centres. Ion beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal healthy tissue, while maximizing cell killing within the tumour. Several ion beam cancer therapy clinical centres are now operating in Europe and elsewhere. However, the full potential of such therapy can only be exploited by better understanding the physical, chemical and biological mechanisms that lead to cell death under ion irradiation. Considering a range of spatio-temporal scales, the proposed action therefore aims to combine the unique experimental and theoretical expertise available within Europe to acquire greater insight at the nanoscopic and molecular level into radiation damage induced by ion impact. Success in this endeavour will be both an important scientific breakthrough and give great impetus to the practical improvement of this innovative therapeutic technique. Ion therapy potentially provides an important advance in cancer therapy and the COST action MP1002 will be very significant in ensuring Europe's leadership in this field, providing the scientific background, required data and mechanistic insight which

  19. Use of the EpiNet database for observational study of status epilepticus in Auckland, New Zealand.

    Science.gov (United States)

    Bergin, Peter; Jayabal, Jayaganth; Walker, Elizabeth; Davis, Suzanne; Jones, Peter; Dalziel, Stuart; Yates, Kim; Thornton, Vanessa; Bennett, Patricia; Wilson, Kaisa; Roberts, Lynair; Litchfield, Rhonda; Te Ao, Braden; Parmer, Priya; Feigin, Valery; Jost, Jeremy; Beghi, Ettore; Rossetti, Andrea O

    2015-08-01

    The EpiNet project has been established to facilitate investigator-initiated clinical research in epilepsy, to undertake epidemiological studies, and to simultaneously improve the care of patients who have records created within the EpiNet database. The EpiNet database has recently been adapted to collect detailed information regarding status epilepticus. An incidence study is now underway in Auckland, New Zealand in which the incidence of status epilepticus in the greater Auckland area (population: 1.5 million) will be calculated. The form that has been developed for this study can be used in the future to collect information for randomized controlled trials in status epilepticus. This article is part of a Special Issue entitled "Status Epilepticus".

  20. Epi proColon(®) 2.0 CE: A Blood-Based Screening Test for Colorectal Cancer.

    Science.gov (United States)

    Lamb, Yvette N; Dhillon, Sohita

    2017-04-01

    Epi proColon(®) 2.0 CE is a blood-based test designed to aid in the early detection of colorectal cancer. The test comprises a qualitative assay for the polymerase chain reaction (PCR) detection of methylated Septin9 DNA, the presence of which is associated with colorectal cancer: however, positive results should be verified by colonoscopy or sigmoidoscopy. Epi proColon(®) 2.0 CE discriminated between patients with colorectal cancer and healthy controls with high clinical sensitivity and specificity in pivotal case-control studies. The sensitivity of the test did not appear to be affected by the tumour location or by patient age or gender. In addition, limited data suggest that Epi proColon(®) 2.0 CE discriminated between patients with colorectal cancer and healthy controls with higher sensitivity and generally similar specificity to that of the faecal immunochemical test, and with higher sensitivity and specificity to that of the guaiac-based faecal occult blood test (statistical data not available). In an observational study, most patients who refused colonoscopy for screening accepted a non-invasive test option as an alternative, and preferred Epi proColon(®) 2.0 CE over a stool-based test. Large prospective trials of Epi proColon(®) 2.0 CE in a screening setting will be required to further elucidate the cost-effectiveness of the test. Nevertheless, currently available data suggests that Epi proColon(®) 2.0 CE has the potential to be a sensitive and convenient screening option for patients refusing screening by colonoscopy.

  1. Effects of growth temperature on characteristics of Mg-delta-doped p-AlInGaN epi-layers

    Science.gov (United States)

    Wu, Zili; Zhang, Xiong; Liang, Tianhui; Feng, Zhe Chuan; Cui, Yiping

    2016-10-01

    The Mg-delta-doped p-AlInGaN epi-layers were successfully grown on c-plane sapphire substrates by metal-organic chemical vapor deposition (MOCVD). The effects of growth temperature on the characteristics of the Mg-delta-doped p-AlInGaN epi-layers were investigated in detail with scanning electron microscopy (SEM), high resolution X-ray diffraction (HR-XRD), photoluminescence (PL), and Hall effect measurements. The characterization results showed that the surfaces of the p-AlInGaN epi-layers were textured with a high density of hexagonal pits, which was found to be strongly dependent on the growth temperature. This feature should be very helpful to enhance the light extraction efficiency when the p-AlInGaN epi-layers were used as the top p-contact layer for making AlInGaN-based deep-ultraviolet light-emitting diodes (DUV-LEDs). In addition, the low temperature PL spectra demonstrated that the Mg-H complex-related broad emission band which was observed for the as-grown p-AlInGaN epi-layer samples was not resolvable for the annealed samples. This fact implies that the Mg-H complex can be effectively dissociated by annealing process. Moreover, owing to the improved In incorporation efficiency and crystalline quality for the p-AlInGaN epi-layers, a hole concentration as high as 1.69 × 1017 cm-3 was achieved with the reformed Mg-delta-doping technique developed in this study.

  2. Scalable Synthesis of the Amber Odorant 9-epi-Ambrox through a Biomimetic Cationic Cyclization/Nucleophilic Bromination Reaction.

    Science.gov (United States)

    Fontaneda, Raquel; Alonso, Pedro; Fañanás, Francisco J; Rodríguez, Félix

    2016-09-16

    A novel biomimetic nucleophilic bromocyclization reaction is used in the key step of a new and straightforward synthesis of 9-epi-Ambrox, an organic compound of high interest and value in the context of fragrances. This strategic reaction allows access to 9-epi-Ambrox on a gram scale from a dienyne derivative, easily available from geraniol, following a sequence of seven steps (35% global yield) with just one purification process. Both enantiomers of the molecule were obtained by a challenging enzymatic resolution.

  3. Epi-detecting label-free multimodal imaging platform using a compact diode-pumped femtosecond solid-state laser

    DEFF Research Database (Denmark)

    Andreana, Marco; Le, Tuan; Hansen, Anders Kragh

    2017-01-01

    We have developed an epi-detected multimodal nonlinear optical microscopy platform based on a compact and cost-effective laser source featuring simultaneous acquisition of signals arising from hyperspectral coherent anti-Stokes Raman scattering (CARS), two-photon fluorescence, and second harmonic...... for these three modalities, achieving sufficient spectral resolution for CARS in the lipid region. The experimental results on a biological tissue reveal that the combination of the epi-detection scheme and the use of a compact diode-pumped femtosecond solid-state laser in the nonlinear optical microscope...

  4. Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro.

    Science.gov (United States)

    Sashidhara, Koneni V; Rosaiah, Jammikuntla N; Kumar, Abdhesh; Bid, Hemant K; Konwar, Rituraj; Chattopadhyay, Naibedya

    2007-11-01

    In the course of our studies on the isolation of bioactive compounds from the roots of Coleus forskohlii, a traditional herb in India, rare 13-epi-sclareol has been isolated, and its structure determined by extensive 2D NMR. This is the first report of isolation from this plant. The isolated compound showed antiproliferative activity in breast and uterine cancers in vitro. The antiproliferative activity of 13-epi-sclareol is comparable to Tamoxifen in terms of IC50 and also showed concentration dependent increased apoptotic changes in the breast cancer cell line, MCF-7.

  5. Biological activity of 1,25-dihydroxyvitamin D sub 2 and 24-epi-1,25-dihydroxyvitamin D sub 2

    Energy Technology Data Exchange (ETDEWEB)

    DeLuca, H.F.; Sicinski, R.R.; Tanaka, Y.; Stern, P.H.; Smith, C.M. (Univ. of Wisconsin, Madison (USA) Northwestern Univ., Chicago, IL (USA))

    1988-04-01

    The biological activity of 1,25-dihydroxyvitamin D{sub 2} (1,25(OH){sub 2}D{sub 2}) and 24-epi-1,25-dihydroxyvitamin D{sub 2} (24-epi-1,25(OH){sub 2}D{sub 2}) has been determined in vitamin D-deficient rats. The biological effectiveness of 1,25(OH){sub 2}D{sub 2} is equal to that reported previously for 1,25-dihydroxyvitamin D{sub 3} (1,25(OH){sub 2}D{sub 3}) in intestinal calcium transport, mineralization of bone, mobilization of bone calcium, and elevation of plasma inorganic phosphorus of rachitic rats. However, 24-epi-1,25(OH){sub 2}D{sub 2} is at best one-half as active as 1,25(OH){sub 2}D{sub 2} in stimulating intestinal calcium transport and in the mineralization of rachitic bone. The 24-epi-1,25(OH){sub 2}D{sub 2} is one-third as active as 1,25(OH){sub 2}D{sub 3} in binding to the chick intestinal receptor for 1,25(OH){sub 2}D{sub 3}. Thus receptor discrimination may account for the twofold difference in intestinal calcium transport activity. 24-Epi-1,25(OH){sub 2}D{sub 2} appeared inactive in in vivo mobilization of bone calcium or bone phosphorus. On the other hand, in fetal rat bone culture, the epi compound was only five times less active than 1,25(OH){sub 2}D{sub 2} in inducing resorption. Short-term experiments on bone mineral mobilization in vivo show that the 24-epi-1,25(OH){sub 2}D{sub 2} does induce bone calcium mobilization but that its activity in this respect is short lived. It is suggested that 24-epi-1,25(OH){sub 2}D{sub 2} is more rapidly degraded in vivo than 1,25(OH){sub 2}D{sub 2}, and, as a result, it shows preferential activity on intestine whose response to a single dose of 1,25(OH){sub 2}D{sub 2} remains for several days, whereas the short-lived bone system does not remain stimulated during the 24-h period between doses.

  6. epiG: statistical inference and profiling of DNA methylation from whole-genome bisulfite sequencing data.

    Science.gov (United States)

    Vincent, Martin; Mundbjerg, Kamilla; Skou Pedersen, Jakob; Liang, Gangning; Jones, Peter A; Ørntoft, Torben Falck; Dalsgaard Sørensen, Karina; Wiuf, Carsten

    2017-02-21

    The study of epigenetic heterogeneity at the level of individual cells and in whole populations is the key to understanding cellular differentiation, organismal development, and the evolution of cancer. We develop a statistical method, epiG, to infer and differentiate between different epi-allelic haplotypes, annotated with CpG methylation status and DNA polymorphisms, from whole-genome bisulfite sequencing data, and nucleosome occupancy from NOMe-seq data. We demonstrate the capabilities of the method by inferring allele-specific methylation and nucleosome occupancy in cell lines, and colon and tumor samples, and by benchmarking the method against independent experimental data.

  7. Overview of the ID, EPI and REL tasks of BioNLP Shared Task 2011

    Directory of Open Access Journals (Sweden)

    Pyysalo Sampo

    2012-06-01

    Full Text Available Abstract We present the preparation, resources, results and analysis of three tasks of the BioNLP Shared Task 2011: the main tasks on Infectious Diseases (ID and Epigenetics and Post-translational Modifications (EPI, and the supporting task on Entity Relations (REL. The two main tasks represent extensions of the event extraction model introduced in the BioNLP Shared Task 2009 (ST'09 to two new areas of biomedical scientific literature, each motivated by the needs of specific biocuration tasks. The ID task concerns the molecular mechanisms of infection, virulence and resistance, focusing in particular on the functions of a class of signaling systems that are ubiquitous in bacteria. The EPI task is dedicated to the extraction of statements regarding chemical modifications of DNA and proteins, with particular emphasis on changes relating to the epigenetic control of gene expression. By contrast to these two application-oriented main tasks, the REL task seeks to support extraction in general by separating challenges relating to part-of relations into a subproblem that can be addressed by independent systems. Seven groups participated in each of the two main tasks and four groups in the supporting task. The participating systems indicated advances in the capability of event extraction methods and demonstrated generalization in many aspects: from abstracts to full texts, from previously considered subdomains to new ones, and from the ST'09 extraction targets to other entities and events. The highest performance achieved in the supporting task REL, 58% F-score, is broadly comparable with levels reported for other relation extraction tasks. For the ID task, the highest-performing system achieved 56% F-score, comparable to the state-of-the-art performance at the established ST'09 task. In the EPI task, the best result was 53% F-score for the full set of extraction targets and 69% F-score for a reduced set of core extraction targets, approaching a level

  8. Diffusion-weighted MRI of the Prostate: Advantages of Zoomed EPI with Parallel-transmit-accelerated 2D-selective Excitation Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Thierfelder, Kolja M.; Scherr, Michael K.; Weiss, Jakob; Mueller-Lisse, Ullrich G.; Theisen, Daniel [Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Munich (Germany); Notohamiprodjo, Mike; Nikolaou, Konstantin [Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Munich (Germany); University Hospital Tuebingen, Department of Diagnostic and Interventional Radiology, Tuebingen (Germany); Dietrich, Olaf [Ludwig-Maximilians-University Hospital Munich, Josef Lissner Laboratory for Biomedical Imaging, Institute for Clinical Radiology, Munich (Germany); Pfeuffer, Josef [Siemens Healthcare, Application Development, Erlangen (Germany)

    2014-12-15

    The purpose of our study was to evaluate the use of 2D-selective, parallel-transmit excitation magnetic resonance imaging (MRI) for diffusion-weighted echo-planar imaging (pTX-EPI) of the prostate, and to compare it to conventional, single-shot EPI (c-EPI). The MRI examinations of 35 patients were evaluated in this prospective study. PTX-EPI was performed with a TX-acceleration factor of 1.7 and a field of view (FOV) of 150 x 90 mm{sup 2}, whereas c-EPI used a full FOV of 380 x 297 mm{sup 2}. Two readers evaluated three different aspects of image quality on 5-point Likert scales. To quantify distortion artefacts, maximum diameters and prostate volume were determined for both techniques and compared to T2-weighted imaging. The zoomed pTX-EPI was superior to c-EPI with respect to overall image quality (3.39 ± 0.62 vs 2.45 ± 0.67) and anatomic differentiability (3.29 ± 0.65 vs 2.41 ± 0.65), each with p < 0.0001. Artefacts were significantly less severe in pTX-EPI (0.93 ± 0.73 vs 1.49 ± 1.08), p < 0.001. The quantitative analysis yielded a higher agreement of pTX-EPI with T2-weighted imaging than c-EPI with respect to coronal (ICCs: 0.95 vs 0.93) and sagittal (0.86 vs 0.73) diameters as well as prostate volume (0.94 vs 0.92). Apparent diffusion coefficient (ADC) values did not differ significantly between the two techniques (p > 0.05). Zoomed pTX-EPI leads to substantial improvements in diffusion-weighted imaging (DWI) of the prostate with respect to different aspects of image quality and severity of artefacts. (orig.)

  9. Metformin synergistically enhances antiproliferative effects of cisplatin and etoposide in NCI-H460 human lung cancer cells

    Directory of Open Access Journals (Sweden)

    Sarah Fernandes Teixeira

    2013-12-01

    Full Text Available OBJECTIVE: To test the effectiveness of combining conventional antineoplastic drugs (cisplatin and etoposide with metformin in the treatment of non-small cell lung cancer in the NCI-H460 cell line, in order to develop new therapeutic options with high efficacy and low toxicity.METHODS: We used the 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT assay and calculated the combination index for the drugs studied.RESULTS: We found that the use of metformin as monotherapy reduced the metabolic viability of the cell line studied. Combining metformin with cisplatin or etoposide produced a synergistic effect and was more effective than was the use of cisplatin or etoposide as monotherapy.CONCLUSIONS: Metformin, due to its independent effects on liver kinase B1, had antiproliferative effects on the NCI-H460 cell line. When metformin was combined with cisplatin or etoposide, the cell death rate was even higher.

  10. Bisdemethoxycurcumin induces DNA damage and inhibits DNA repair associated protein expressions in NCI-H460 human lung cancer cells.

    Science.gov (United States)

    Yu, Chien-Chih; Yang, Su-Tso; Huang, Wen-Wen; Peng, Shu-Fen; Huang, An-Cheng; Tang, Nou-Ying; Liu, Hsin-Chung; Yang, Mei-Due; Lai, Kuang-Chi; Chung, Jing-Gung

    2016-12-01

    Nonsmall cell lung carcinoma (NSCLC) is a devastating primary lung tumor resistant to conventional therapies. Bisdemethoxycurcumin (BDMC) is one of curcumin derivate from Turmeric and has been shown to induce NSCLC cell death. Although there is one report to show BDMC induced DNA double strand breaks, however, no available information to show BDMC induced DNA damage action with inhibited DNA repair protein in lung cancer cells in detail. In this study, we tested BDMC-induced DNA damage and condensation in NCI-H460 cells by using Comet assay and DAPI staining examinations, respectively and we found BDMC induced DNA damage and condension. Western blotting was used to examine the effects of BDMC on protein expression associated with DNA damage and repair and results indicated that BDMC suppressed the protein levels associated with DNA damage and repair, such as 14-3-3σ (an important checkpoint keeper of DDR), O6-methylguanine-DNA methyltransferase, DNA repair proteins breast cancer 1, early onset, mediator of DNA damage checkpoint 1 but activate phosphorylated p53 and p-H2A.X (phospho Ser140) in NCI-H460 cells. Confocal laser systems microscopy was used for examining the protein translocation and results show that BDMC increased the translocation of p-p53 and p-H2A.X (phospho Ser140) from cytosol to nuclei in NCI-H460 cells. In conclusion, BDMC induced DNA damage and condension and affect DNA repair proteins in NCI-H460 cells in vitro. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1859-1868, 2016. © 2015 Wiley Periodicals, Inc.

  11. Matrine suppresses invasion and metastasis of NCI-H1299 cells by enhancing microRNA-133a expression.

    Science.gov (United States)

    Liao, Hehe; Zhao, Xixi; Qu, Jinkun; Zhang, Jia; Cai, Hui

    2015-01-01

    Matrine has been proved to inhibit proliferation and induce apoptosis of human lung cancer cells. However, less studies involved in evaluating the effects and mechanism of matrine in cell migration and invasion of lung cancer. This study was aim to investigate the involvement of miR-133a in matrine's anti-invasion and anti-metastasis in lung cancer. MTT assay was used to assess the inhibition of proliferation effects of matrine in NCI-H1299 cells. Migration and invasion abilities of NCI-H1299 cells were investigated by Transwell assays. Expression of miR-133a was detected by real-time PCR. Anti-miR technique was applied to inhibit miR-133a in matrine treated HCI-H1299 cells. Real-time PCR and Western blotting were performed to evaluate the activation of EGFR/Akt/MMP-9 pathway. As results, matrine treatment significantly inhibited proliferation, migration and invasion of NCI-H1299 cells in a concentration-dependent manner, accompanied by significantly elevation of miR-133a expression. However, matrine failed to inhibit the metastatic ability when cells transfected with anti-miR-133a. Matrine treatment also suppressed activation of EGFR/Akt/MMP-9 pathway. The inhibitory effects of matrine on activation of EGFR pathway were also reversed by anti-miR-133a transfection in NCI-H1299 cells. In conclusion, matrine inhibited the invasion and metastasis of lung cancer cell by elevating expression of miR-133a which further suppressed activation of EGFR/Akt/MMP-9 pathway.

  12. An efficient anti-occlusion depth estimation using generalized EPI representation in light field

    Science.gov (United States)

    Zhu, Hao; Wang, Qing

    2016-10-01

    Light field cameras have been rapidly developed and are likely to appear in mobile devices in near future. It is essential to develop efficient and robust depth estimation algorithm for mobile applications. However, existing methods are either slow or lack of adaptability to occlusion such that they are not suitable to mobile computing platform. In this paper, we present the generalized EPI representation in light field and formulate it using two linear functions. By combining it with the light field occlusion theory, a highly efficient and anti-occlusion depth estimation algorithm is proposed. Our algorithm outperforms the previous local method, especially in occlusion areas. Experimental results on public light field datasets have demonstrated the effectiveness and efficiency of the proposed algorithm.

  13. Development of ultra pure germanium epi layers for blocked impurity band far infrared detectors

    Energy Technology Data Exchange (ETDEWEB)

    Lutz, M.P.

    1991-05-01

    The main goals of this paper are: (1) To develop a low-pressure CVD (LPCVD) process that allows epitaxial growth at lower temperatures. Lower temperatures will allow the achievement of a sharp dopant profile at the substrate/epi-layer interface. Less out-diffusion from the substrate would allow the use of thinner epitaxial layers, which would lead to a larger depletion width in the photoactive region. LPCVD also avoids, to a great extent, gas-phase nucleation, which would cause Ge particulates to fall onto the wafer surface during growth. (2) To reduce high levels of oxygen and copper present at the wafer interface, as observed by secondary ion mass spectroscopy (SIMS). In order to achieve high-quality epitaxial layers, it is imperative that the substrate surface be of excellent quality. (3) To make and test detectors, after satisfactory epitaxial layers have been made.

  14. Mid-infrared broadband absorber of full semiconductor epi-layers

    Science.gov (United States)

    Wang, Shaohua; Wang, Yufei; Zhang, Siriguleng; Zheng, Wanhua

    2017-04-01

    We demonstrate mid-infrared dual channel near-perfect absorbers based on full semiconductor epi-layers theoretically. Strong absorption (>99.9%) is observed at 25.04 THz. Through introducing composite grating and controlling the thickness of the dielectric layer, we can get a broadband absorption with absorptivity above 80% at the range from 8 μm to 12 μm with a good incidence angle tolerance. The structure investigated in this paper shows a broadband, all-semiconductor, plasmonic architecture, which is of great importance for many applications such as bolometers, cloaking, imaging devices and also can be used in enhancing interaction of mid-infrared radiation with integrated semiconductor optoelectronic elements.

  15. A new syndrome of 'spondylo-epi-metaphyseal dysplasia: mixed type''

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, B.G. [Department of Radiology, Al Afia Hospital, Houn, Al-Jufra (Libya)

    2003-02-01

    A new type of rare bone dysplasia is described, which shares some common features with spondylo-meta-epiphyseal dysplasia: short limb-abnormal calcification type and lethal metatropic dysplasia. Besides these features, the present case has some additional unusual features. Facial malformation was very obvious and of a different type. The nose and nares were completely flattened. Hypertrophied acetabular bones, round densities on the ilia, premature ossification of many epiphyses and carpal bones, curvilinear calcifications in some joints, fusion of the ischiopubic rami, calcification of many costal cartilages and thick sclerotic base of the skull were a few of the significant findings. On the basis of the clinical and radiological features, the condition has been named ''spondylo-epi-metaphyseal dysplasia: mixed type''. (orig.)

  16. EpiPOD : community vaccination and dispensing model user's guide.

    Energy Technology Data Exchange (ETDEWEB)

    Berry, M.; Samsa, M.; Walsh, D.; Decision and Information Sciences

    2009-01-09

    EpiPOD is a modeling system that enables local, regional, and county health departments to evaluate and refine their plans for mass distribution of antiviral and antibiotic medications and vaccines. An intuitive interface requires users to input as few or as many plan specifics as are available in order to simulate a mass treatment campaign. Behind the input interface, a system dynamics model simulates pharmaceutical supply logistics, hospital and first-responder personnel treatment, population arrival dynamics and treatment, and disease spread. When the simulation is complete, users have estimates of the number of illnesses in the population at large, the number of ill persons seeking treatment, and queuing and delays within the mass treatment system--all metrics by which the plan can be judged.

  17. A Novel Epi-drug Therapy Based on the Suppression of BET Family Epigenetic Readers

    Science.gov (United States)

    Shin, Dong-Guk; Bayarsaihan, Dashzeveg

    2017-01-01

    Recent progress in epigenetic research has made a profound influence on pharmacoepigenomics, one of the fastest growing disciplines promising to provide new epi-drugs for the treatment of a broad range of diseases. Histone acetylation is among the most essential chromatin modifications underlying the dynamics of transcriptional activation. The acetylated genomic regions recruit the BET (bromodomain and extra-terminal) family of bromodomains (BRDs), thereby serving as a molecular scaffold in establishing RNA polymerase II specificity. Over the past several years, the BET epigenetic readers have become the main targets for drug therapy. The discovery of selective small-molecule compounds with capacity to inhibit BET proteins has paved a path for developing novel strategies against cancer, cardiovascular, skeletal, and inflammatory diseases. Therefore, further research into small chemicals impeding the regulatory activity of BRDs could offer therapeutic benefits for many health problems including tumor growth, heart disease, oral, and bone disorders. PMID:28356894

  18. Revisió dels odonats valencians de la col·lecció d’artròpodes del Museu de Ciències Naturals de Barcelona

    Directory of Open Access Journals (Sweden)

    Fontana-Bria, L.

    2012-07-01

    Full Text Available Revision of Valencian dragonflies in the arthropod collection at the Museu de Ciències Naturals de Barcelona The current work shows the species of Valencian dragonflies preserved in the arthropod collection at the Museu de Ciències Naturals de Barcelona (Spain. The collection contains a total of 33 specimens belonging to 12 species, representing 18% of the known species in the Autonomous Community of Valencia.

  19. A systems approach reveals distinct metabolic strategies among the NCI-60 cancer cell lines

    Science.gov (United States)

    Aurich, Maike K.; Fleming, Ronan M. T.; Thiele, Ines

    2017-01-01

    The metabolic phenotype of cancer cells is reflected by the metabolites they consume and by the byproducts they release. Here, we use quantitative, extracellular metabolomic data of the NCI-60 panel and a novel computational method to generate 120 condition-specific cancer cell line metabolic models. These condition-specific cancer models used distinct metabolic strategies to generate energy and cofactors. The analysis of the models’ capability to deal with environmental perturbations revealed three oxotypes, differing in the range of allowable oxygen uptake rates. Interestingly, models based on metabolomic profiles of melanoma cells were distinguished from other models through their low oxygen uptake rates, which were associated with a glycolytic phenotype. A subset of the melanoma cell models required reductive carboxylation. The analysis of protein and RNA expression levels from the Human Protein Atlas showed that IDH2, which was an essential gene in the melanoma models, but not IDH1 protein, was detected in normal skin cell types and melanoma. Moreover, the von Hippel-Lindau tumor suppressor (VHL) protein, whose loss is associated with non-hypoxic HIF-stabilization, reductive carboxylation, and promotion of glycolysis, was uniformly absent in melanoma. Thus, the experimental data supported the predicted role of IDH2 and the absence of VHL protein supported the glycolytic and low oxygen phenotype predicted for melanoma. Taken together, our approach of integrating extracellular metabolomic data with metabolic modeling and the combination of different network interrogation methods allowed insights into the metabolism of cells. PMID:28806730

  20. NCI Funding Trends and Priorities in Physical Activity and Energy Balance Research Among Cancer Survivors.

    Science.gov (United States)

    Alfano, Catherine M; Bluethmann, Shirley M; Tesauro, Gina; Perna, Frank; Agurs-Collins, Tanya; Elena, Joanne W; Ross, Sharon A; O'Connell, Mary; Bowles, Heather R; Greenberg, Deborah; Nebeling, Linda

    2016-01-01

    There is considerable evidence that a healthy lifestyle consisting of physical activity, healthy diet, and weight control is associated with reduced risk of morbidity and mortality after cancer. However, these behavioral interventions are not widely adopted in practice or community settings. Integrating heath behavior change interventions into standard survivorship care for the growing number of cancer survivors requires an understanding of the current state of the science and a coordinated scientific agenda for the future with focused attention in several priority areas. To facilitate this goal, this paper presents trends over the past decade of the National Cancer Institute (NCI) research portfolio, fiscal year 2004 to 2014, by funding mechanism, research focus, research design and methodology, primary study exposures and outcomes, and study team expertise and composition. These data inform a prioritized research agenda for the next decade focused on demonstrating value and feasibility and creating desire for health behavior change interventions at multiple levels including the survivor, clinician, and healthcare payer to facilitate the development and implementation of appropriately targeted, adaptive, effective, and sustainable programs for all survivors. Published by Oxford University Press (2015). This work is written by (a) US Government employee(s) and is in the public domain in the US.

  1. Pancreatitis-diabetes-pancreatic cancer: summary of an NIDDK-NCI workshop.

    Science.gov (United States)

    Andersen, Dana K; Andren-Sandberg, Åke; Duell, Eric J; Goggins, Michael; Korc, Murray; Petersen, Gloria M; Smith, Jill P; Whitcomb, David C

    2013-11-01

    A workshop sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Cancer Institute (NCI) on "Pancreatitis-Diabetes-Pancreatic Cancer" focused on the risk factors of chronic pancreatitis (CP) and diabetes mellitus (DM) on the development of pancreatic ductal adenocarcinoma (PDAC). Sessions were held on (a) an overview of the problem of PDAC; (b) CP as a risk factor of PDAC; (c) DM as a risk factor of PDAC; (d) pancreatogenic, or type 3c, DM; (e) genomic associations of CP, DM, and PDAC; (f) surveillance of high-risk populations and early detection of PDAC; and (g) effects of DM treatment on PDAC. Recent data and current understandings of the mechanisms of CP- and DM-associated factors on PDAC development were discussed, and a detailed review of the possible risks of DM treatment on the development of PDAC was provided by representatives from academia, industry, and the Food and Drug Administration. The current status of possible biomarkers of PDAC and surveillance strategies for high-risk populations were discussed, and the gaps in knowledge and opportunities for further research were elucidated. A broad spectrum of expertise of the speakers and the discussants provided an unusually productive workshop, the highlights of which are summarized in the accompanying article.

  2. Nonlinear quantitative radiation sensitivity prediction model based on NCI-60 cancer cell lines.

    Science.gov (United States)

    Zhang, Chunying; Girard, Luc; Das, Amit; Chen, Sun; Zheng, Guangqiang; Song, Kai

    2014-01-01

    We proposed a nonlinear model to perform a novel quantitative radiation sensitivity prediction. We used the NCI-60 panel, which consists of nine different cancer types, as the platform to train our model. Important radiation therapy (RT) related genes were selected by significance analysis of microarrays (SAM). Orthogonal latent variables (LVs) were then extracted by the partial least squares (PLS) method as the new compressive input variables. Finally, support vector machine (SVM) regression model was trained with these LVs to predict the SF2 (the surviving fraction of cells after a radiation dose of 2 Gy γ-ray) values of the cell lines. Comparison with the published results showed significant improvement of the new method in various ways: (a) reducing the root mean square error (RMSE) of the radiation sensitivity prediction model from 0.20 to 0.011; and (b) improving prediction accuracy from 62% to 91%. To test the predictive performance of the gene signature, three different types of cancer patient datasets were used. Survival analysis across these different types of cancer patients strongly confirmed the clinical potential utility of the signature genes as a general prognosis platform. The gene regulatory network analysis identified six hub genes that are involved in canonical cancer pathways.

  3. Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68

    Directory of Open Access Journals (Sweden)

    Bedognetti Davide

    2011-10-01

    Full Text Available Abstract Background Oncolytic viral therapy represents an alternative therapeutic strategy for the treatment of cancer. We previously described GLV-1h68, a modified Vaccinia Virus with exclusive tropism for tumor cells, and we observed a cell line-specific relationship between the ability of GLV-1h68 to replicate in vitro and its ability to colonize and eliminate tumor in vivo. Methods In the current study we surveyed the in vitro permissivity to GLV-1h68 replication of the NCI-60 panel of cell lines. Selected cell lines were also tested for permissivity to another Vaccinia Virus and a vesicular stomatitis virus (VSV strain. In order to identify correlates of permissity to viral infection, we measured transcriptional profiles of the cell lines prior infection. Results We observed highly heterogeneous permissivity to VACV infection amongst the cell lines. The heterogeneity of permissivity was independent of tissue with the exception of B cell derivation. Cell lines were also tested for permissivity to another Vaccinia Virus and a vesicular stomatitis virus (VSV strain and a significant correlation was found suggesting a common permissive phenotype. While no clear transcriptional pattern could be identified as predictor of permissivity to infection, some associations were observed suggesting multifactorial basis permissivity to viral infection. Conclusions Our findings have implications for the design of oncolytic therapies for cancer and offer insights into the nature of permissivity of tumor cells to viral infection.

  4. Automatic segmentation of pulmonary nodules on CT images by use of NCI lung image database consortium

    Science.gov (United States)

    Tachibana, Rie; Kido, Shoji

    2006-03-01

    Accurate segmentation of small pulmonary nodules (SPNs) on thoracic CT images is an important technique for volumetric doubling time estimation and feature characterization for the diagnosis of SPNs. Most of the nodule segmentation algorithms that have been previously presented were designed to handle solid pulmonary nodules. However, SPNs with ground-glass opacity (GGO) also affects a diagnosis. Therefore, we have developed an automated volumetric segmentation algorithm of SPNs with GGO on thoracic CT images. This paper presents our segmentation algorithm with multiple fixed-thresholds, template-matching method, a distance-transformation method, and a watershed method. For quantitative evaluation of the performance of our algorithm, we used the first dataset provided by NCI Lung Image Database Consortium (LIDC). In the evaluation, we employed the coincident rate which was calculated with both the computerized segmented region of a SPN and the matching probability map (pmap) images provided by LIDC. As the result of 23 cases, the mean of the total coincident rate was 0.507 +/- 0.219. From these results, we concluded that our algorithm is useful for extracting SPNs with GGO and solid pattern as well as wide variety of SPNs in size.

  5. Detecting Role Errors in the Gene Hierarchy of the NCI Thesaurus

    Directory of Open Access Journals (Sweden)

    Yehoshua Perl

    2008-01-01

    Full Text Available Gene terminologies are playing an increasingly important role in the ever-growing field of genomic research. While errors in large, complex terminologies are inevitable, gene terminologies are even more susceptible to them due to the rapid growth of genomic knowledge and the nature of its discovery. It is therefore very important to establish quality- assurance protocols for such genomic-knowledge repositories. Different kinds of terminologies oftentimes require auditing methodologies adapted to their particular structures. In light of this, an auditing methodology tailored to the characteristics of the NCI Thesaurus’s (NCIT’s Gene hierarchy is presented. The Gene hierarchy is of particular interest to the NCIT’s designers due to the primary role of genomics in current cancer research. This multiphase methodology focuses on detecting role-errors, such as missing roles or roles with incorrect or incomplete target structures, occurring within that hierarchy. The methodology is based on two kinds of abstraction networks, called taxonomies, that highlight the role distribution among concepts within the IS-A (subsumption hierarchy. These abstract views tend to highlight portions of the hierarchy having a higher concentration of errors. The errors found during an application of the methodology

  6. Detecting Role Errors in the Gene Hierarchy of the NCI Thesaurus

    Science.gov (United States)

    Min, Hua; Cohen, Barry; Halper, Michael; Oren, Marc; Perl, Yehoshua

    2008-01-01

    Gene terminologies are playing an increasingly important role in the ever-growing field of genomic research. While errors in large, complex terminologies are inevitable, gene terminologies are even more susceptible to them due to the rapid growth of genomic knowledge and the nature of its discovery. It is therefore very important to establish quality-assurance protocols for such genomic-knowledge repositories. Different kinds of terminologies oftentimes require auditing methodologies adapted to their particular structures. In light of this, an auditing methodology tailored to the characteristics of the NCI Thesaurus’s (NCIT’s) Gene hierarchy is presented. The Gene hierarchy is of particular interest to the NCIT’s designers due to the primary role of genomics in current cancer research. This multiphase methodology focuses on detecting role-errors, such as missing roles or roles with incorrect or incomplete target structures, occurring within that hierarchy. The methodology is based on two kinds of abstraction networks, called taxonomies, that highlight the role distribution among concepts within the IS-A (subsumption) hierarchy. These abstract views tend to highlight portions of the hierarchy having a higher concentration of errors. The errors found during an application of the methodology are reported. Hypotheses pertaining to the efficacy of our methodology are investigated. PMID:19221606

  7. Nonlinear Quantitative Radiation Sensitivity Prediction Model Based on NCI-60 Cancer Cell Lines

    Directory of Open Access Journals (Sweden)

    Chunying Zhang

    2014-01-01

    Full Text Available We proposed a nonlinear model to perform a novel quantitative radiation sensitivity prediction. We used the NCI-60 panel, which consists of nine different cancer types, as the platform to train our model. Important radiation therapy (RT related genes were selected by significance analysis of microarrays (SAM. Orthogonal latent variables (LVs were then extracted by the partial least squares (PLS method as the new compressive input variables. Finally, support vector machine (SVM regression model was trained with these LVs to predict the SF2 (the surviving fraction of cells after a radiation dose of 2 Gy γ-ray values of the cell lines. Comparison with the published results showed significant improvement of the new method in various ways: (a reducing the root mean square error (RMSE of the radiation sensitivity prediction model from 0.20 to 0.011; and (b improving prediction accuracy from 62% to 91%. To test the predictive performance of the gene signature, three different types of cancer patient datasets were used. Survival analysis across these different types of cancer patients strongly confirmed the clinical potential utility of the signature genes as a general prognosis platform. The gene regulatory network analysis identified six hub genes that are involved in canonical cancer pathways.

  8. Efflux pump inhibitors (EPIs as new antimicrobial agents against Pseudomonas aeruginosa

    Directory of Open Access Journals (Sweden)

    Momen Askoura

    2011-05-01

    Full Text Available Pseudomonas aeruginosa is an opportunistic human pathogen and one of the leading causes of nosocomial infections worldwide. The difficulty in treatment of pseudomonas infections arises from being multidrug resistant (MDR and exhibits resistance to most antimicrobial agents due to the expression of different mechanisms overcoming their effects. Of these resistance mechanisms, the active efflux pumps in Pseudomonas aeruginosa that belong to the resistance nodulation division (RND plays a very important role in extruding the antibiotics outside the bacterial cells providing a protective means against their antibacterial activity. Beside its role against the antimicrobial agents, these pumps can extrude biocides, detergents, and other metabolic inhibitors. It is clear that efflux pumps can be targets for new antimicrobial agents. Peptidomimetic compounds such as phenylalanine arginyl β-naphthylamide (PAβN have been introduced as efflux pump inhibitors (EPIs; their mechanism of action is through competitive inhibition with antibiotics on the efflux pump resulting in increased intracellular concentration of antibiotic, hence, restoring its antibacterial activity. The advantage of EPIs is the difficulty to develop bacterial resistance against them, but the disadvantage is their toxic property hindering their clinical application. The structure activity relationship of these compounds showed other derivatives from PAβN that are higher in their activity with higher solubility in biological fluids and decreased toxicity level. This raises further questions on how can we compact Pseudomonas infections. Of particular importance, the recent resurgence in the use of older antibiotics such as polymyxins and probably applying stricter control measures in order to prevent their spread in clinical sittings.

  9. Future perspectives in melanoma research : Meeting report from the "Melanoma Bridge". Napoli, December 1st-4th 2015.

    Science.gov (United States)

    Ascierto, Paolo A; Agarwala, Sanjiv; Botti, Gerardo; Cesano, Alessandra; Ciliberto, Gennaro; Davies, Michael A; Demaria, Sandra; Dummer, Reinhard; Eggermont, Alexander M; Ferrone, Soldano; Fu, Yang Xin; Gajewski, Thomas F; Garbe, Claus; Huber, Veronica; Khleif, Samir; Krauthammer, Michael; Lo, Roger S; Masucci, Giuseppe; Palmieri, Giuseppe; Postow, Michael; Puzanov, Igor; Silk, Ann; Spranger, Stefani; Stroncek, David F; Tarhini, Ahmad; Taube, Janis M; Testori, Alessandro; Wang, Ena; Wargo, Jennifer A; Yee, Cassian; Zarour, Hassane; Zitvogel, Laurence; Fox, Bernard A; Mozzillo, Nicola; Marincola, Francesco M; Thurin, Magdalena

    2016-11-15

    The sixth "Melanoma Bridge Meeting" took place in Naples, Italy, December 1st-4th, 2015. The four sessions at this meeting were focused on: (1) molecular and immune advances; (2) combination therapies; (3) news in immunotherapy; and 4) tumor microenvironment and biomarkers. Recent advances in tumor biology and immunology has led to the development of new targeted and immunotherapeutic agents that prolong progression-free survival (PFS) and overall survival (OS) of cancer patients. Immunotherapies in particular have emerged as highly successful approaches to treat patients with cancer including melanoma, non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), bladder cancer, and Hodgkin's disease. Specifically, many clinical successes have been using checkpoint receptor blockade, including T cell inhibitory receptors such as cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death-1 (PD-1) and its ligand PD-L1. Despite demonstrated successes, responses to immunotherapy interventions occur only in a minority of patients. Attempts are being made to improve responses to immunotherapy by developing biomarkers. Optimizing biomarkers for immunotherapy could help properly select patients for treatment and help to monitor response, progression and resistance that are critical challenges for the immuno-oncology (IO) field. Importantly, biomarkers could help to design rational combination therapies. In addition, biomarkers may help to define mechanism of action of different agents, dose selection and to sequence drug combinations. However, biomarkers and assays development to guide cancer immunotherapy is highly challenging for several reasons: (i) multiplicity of immunotherapy agents with different mechanisms of action including immunotherapies that target activating and inhibitory T cell receptors (e.g., CTLA-4, PD-1, etc.); adoptive T cell therapies that include tissue infiltrating lymphocytes (TILs), chimeric antigen receptors (CARs), and

  10. Highlights of recent developments and trends in cancer nanotechnology research--view from NCI Alliance for Nanotechnology in Cancer.

    Science.gov (United States)

    Hull, L C; Farrell, D; Grodzinski, P

    2014-01-01

    Although the incidence of cancer and cancer related deaths in the United States has decreased over the past two decades due to improvements in early detection and treatment, cancer still is responsible for a quarter of the deaths in this country. There is much room for improvement on the standard treatments currently available and the National Cancer Institute (NCI) has recognized the potential for nanotechnology and nanomaterials in this area. The NCI Alliance for Nanotechnology in Cancer was formed in 2004 to support multidisciplinary researchers in the application of nanotechnology to cancer diagnosis and treatment. The researchers in the Alliance have been productive in generating innovative solutions to some of the central issues of cancer treatment including how to detect tumors earlier, how to target cancer cells specifically, and how to improve the therapeutic index of existing chemotherapies and radiotherapy treatments. Highly creative ideas are being pursued where novelty in nanomaterial development enables new modalities of detection or therapy. This review highlights some of the innovative materials approaches being pursued by researchers funded by the NCI Alliance. Their discoveries to improve the functionality of nanoparticles for medical applications includes the generation of new platforms, improvements in the manufacturing of nanoparticles and determining the underlying reasons for the movement of nanoparticles in the blood. © 2013.

  11. Analysis of Pathway Activity in Primary Tumors and NCI60 Cell Lines Using Gene Expression Profiling Data

    Institute of Scientific and Technical Information of China (English)

    Xing-Dong Feng; Jude E. Onyia; Shu-Yu Li; Shu-Guang Huang; Jian-Yong Shou; Bi-Rong Liao; Jonathan M. Yingling; Xiang Ye; Xi Lin; Lawrence M. Gelbert; Eric W. Su

    2007-01-01

    To determine cancer pathway activities in nine types of primary tumors and NCI60 cell lines, we applied an in silico approach by examining gene signatures reflective of consequent pathway activation using gene expression data. Supervised learning approaches predicted that the Ras pathway is active in ~70% of lung adenocarcinomas but inactive in most squamous cell carcinomas, pulmonary carcinoids, and small cell lung carcinomas. In contrast, the TGF-β, TNF-α, Src, Myc, E2F3, and β-catenin pathways are inactive in lung adenocarcinomas. We predicted an active Ras, Myc, Src, and/or E2F3 pathway in significant percentages of breast cancer, colorectal carcinoma, and gliomas. Our results also suggest that Ras may be the most prevailing oncogenic pathway. Additionally, many NCI60 cell lines exhibited a gene signature indicative of an active Ras, Myc, and/or Src, but not E2F3, β-catenin, TNF-α, or TGF-β pathway. To our knowledge, this is the first comprehensive survey of cancer pathway activities in nine major tumor types and the most widely used NCI60 cell lines. The "gene expression pathway signatures" we have defined could facilitate the understanding of molecular mechanisms in cancer development and provide guidance to the selection of appropriate cell lines for cancer research and pharmaceutical compound screening.

  12. Spergularia marina induces glucagon-like peptide-1 secretion in NCI-H716 cells through bile acid receptor activation.

    Science.gov (United States)

    Kim, Kyong; Lee, Yu Mi; Rhyu, Mee-Ra; Kim, Hye Young

    2014-11-01

    Spergularia marina Griseb. (SM) is a halophyte that grows in mud flats. The aerial portions of SM have been eaten as vegetables and traditionally used to prevent chronic diseases in Korea. However, there has been no scientific report that demonstrates the pharmacological effects of SM. Glucagon-like peptide-1 (GLP-1) is important for the maintenance of glucose and energy homeostasis through acting as a signal in peripheral and neural systems. To discover a functional food for regulating glucose and energy homeostasis, we evaluated the effect of an aqueous ethanolic extract (AEE) of SM on GLP-1 release from enteroendocrine NCI-H716 cells. In addition, we explored the Takeda G-protein-coupled receptor 5 (TGR5) agonist activity of AEE-SM in Chinese hamster ovary (CHO)-K1 cells transiently transfected with human TGR5. As a result, treatment of NCI-H716 cells with AEE-SM increased GLP-1 secretion and intracellular Ca(2+) and cyclic AMP (cAMP) levels in a dose-dependent manner. Transfection of NCI-H716 cells with TGR5-specific small interference RNA inhibited AEE-SM-induced GLP-1 secretion and the increase in Ca(2+) and cAMP levels. Moreover, AEE-SM showed that the TGR5 agonist activity in CHO-K1 cells transiently transfected with TGR5. The results suggest that AEE-SM might be a candidate for a functional food to regulate glucose and energy homeostasis.

  13. Rationale, Procedures, and Response Rates for the 2015 Administration of NCI's Health Information National Trends Survey: HINTS-FDA 2015.

    Science.gov (United States)

    Blake, Kelly D; Portnoy, David B; Kaufman, Annette R; Lin, Chung-Tung Jordan; Lo, Serena C; Backlund, Eric; Cantor, David; Hicks, Lloyd; Lin, Amy; Caporaso, Andrew; Davis, Terisa; Moser, Richard P; Hesse, Bradford W

    2016-12-01

    The National Cancer Institute (NCI) developed the Health Information National Trends Survey (HINTS) to monitor population trends in cancer communication practices, information preferences, health risk behaviors, attitudes, and cancer knowledge. The U.S. Food and Drug Administration (FDA) recognized HINTS as a unique data resource for informing its health communication endeavors and partnered with NCI to field HINTS-FDA 2015. HINTS-FDA 2015 was a self-administered paper instrument sent by mail May 29 to September 8, 2015, using a random probability-based sample of U.S. postal addresses stratified by county-level smoking rates, with an oversampling of high and medium-high smoking strata to increase the yield of current smokers responding to the survey. The response rate for HINTS-FDA 2015 was 33% (N = 3,738). The yield of current smokers (n = 495) was lower than expected, but the sampling strategy achieved the goal of obtaining more former smokers (n = 1,132). Public-use HINTS-FDA 2015 data and supporting documentation have been available for download and secondary data analyses since June 2016 at http://hints.cancer.gov . NCI and FDA encourage the use of HINTS-FDA for health communication research and practice related to tobacco-related communications, public knowledge, and behaviors as well as beliefs and actions related to medical products and dietary supplements.

  14. Les competències. La doctrina del Tribunal sobre la definició de les competències. Les competències exclusives, les compartides i les executives. - Las competencias. La doctrina del Tribunal sobre la definición de las competencias. Competencias exclusivas, compartidas y ejecutivas.

    Directory of Open Access Journals (Sweden)

    Ramon Riu

    2010-07-01

    Full Text Available La doctrina de la Sentència 31/2010 sobre la definició estatutària de les categories competencials (251-257 Mercè Barceló i SerramaleraLa doctrina del Tribunal Constitucional sobre la definició de competències. Les competències exclusives, les compartides i les executives (258-261Antoni Bayona RocamoraLa doctrina de la Sentència 31/2010 sobre les competències executives (Xavier Bernadí GilLa doctrina del Tribunal sobre la definició de les competències. Les ompetències exclusives, les compartides i les executives (270-276Marc Carrillo LópezEls efectes de la Sentència sobre la definició estatutària de les competències: la «devaluació» jurídica dels estatuts d’autonomia (277-281Mercè Corretja TorrensLes categories funcionals de competències a l’Estatut d’autonomia de Catalunya. Comentaris a la Sentència 31/2010 (282-287Ramon Riu FortunyTipologia de les competències. El seu abast funcional: els articles 110 a 112 (288-294Joaquín Tornos Massostenella e no enmendalla (262-269 La doctrina de la Sentencia 31/2010 sobre la definición estatutaria de las categorías competenciales (251-257Mercè Barceló i SerramaleraLa doctrina del Tribunal Constitucional sobre la definición de competencias. Las competencias exclusivas, las compartidas y las ejecutivas (258-261Antoni Bayona RocamoraLa doctrina de la Sentencia 31/2010 sobre las competencias ejecutivas (sostenella e no enmendalla (262-270 Xavier Bernadí GilLa doctrina del Tribunal sobre la definición de las competencias. Las competencias exclusivas, las compartidas y las ejecutivas (271-277Marc Carrillo LópezLos efectos de la Sentencia sobre la definición estatutaria de las competencias:la «devaluación» jurídica de los estatutos de autonomía (278-283Mercè Corretja TorrensLas categorías funcionales de competencias en el Estatuto de Autonomía de Cataluña. Comentarios a la Sentencia 31/2010 (284-289Ramon Riu FortunyTipología de las competencias. Su alcance

  15. On the Discovery of Eastern Hellenistic Initiatory Altar of the 3rd – 1st Centuries BC Depicting the Plot of Bull Sacrifice in the City of Stavropol

    Directory of Open Access Journals (Sweden)

    Prokopenko Yuriy A.

    2016-10-01

    Full Text Available The article is devoted to the semantic and chronological analysis of the images on the plate of white tuff discovered in the city of Stavropol. The central part of the relief is occupied with the image of table – an altar with hoisted bull head (in the background and the hanging part of bull skin (in the foreground. Between the protruding edges of the hanging skin and lower to the ground (between the legs of the altar an ancient Greek phrase carved in three lines. The composition is completed by flanking images of two figures in long robes depicted in profile, symmetrically turned to the head of the bull. The figure at the right is an image of a man with a long beard, the lower edge of which is bent forward (priest or king. The figure at the left is a female (queen. Both the man and the woman are holding ritual vessels in hands. The plot of bull sacrifice is typical for the cultural traditions of ancient Greece as well as for ancient eastern states. The fact of combining images and inscriptions peculiar of the Hellenistic culture and ancient Iranian mythology on the Stavropol altar should be associated with the religious policy pursued by the Pontic kings since the second half of the 3rd century BC till the Common Era. This policy was focused on the gradual replacement of local cults by Greek ones in the official pantheon. The reasons for the Asia Minor altar existence in the Stavropol Upland include: 1 the military expeditions of the Sarmatians to Asia Minor in 2nd – 1st centuries BC; 2 the establishment of political and economic ties by the North Caucasus population with the state of Seleucids in the 2nd century BC, with Parthia in the 2nd – 1st centuries BC, and especially with the kingdom of Pontus in the 1st century BC.

  16. High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen.

    Directory of Open Access Journals (Sweden)

    Kim Steegen

    Full Text Available BACKGROUND: The knowledge-base of emerging drug resistance profiles in children exposed to abacavir-based antiretroviral regimens in South Africa is very limited. This study investigated the suitability of didanosine-based 2nd-line regimens for children in the context of antiretroviral drug resistance patterns emerging after 1st-line virologic failure. METHODS: A retrospective dataset of 354 antiretroviral drug resistant genotypes from children failing either abacavir (n = 81 or stavudine (n = 273 based 1st-line regimens, was analysed. Samples were sent to the HIV genotyping laboratory at Charlotte Maxeke Johannesburg Academic Hospital, for routine testing. Pol sequences were submitted to the Stanford HIV drug resistance database for genotypic predictions. RESULTS: Children were exposed to abacavir or stavudine-based 1st-line regimens for an average of 21 and 36 months, respectively. The frequency of reduced susceptibility to didanosine was substantial in the abacavir-exposed group (69.1%.This reduced susceptibility was commonly attributed to L74V/I (n = 44 and to a lesser extent K65R (n = 10 mutations. Didanosine resistance was observed in 43.2% of patients exposed to stavudine-based regimens. In contrast, most children remained susceptible to stavudine regardless of exposure to abacavir (77.8% or stavudine (74.7%. At least 80% of children remained susceptible to zidovudine irrespective of stavudine or abacavir-exposure. The presence of the K65R mutation was more common after abacavir pressure (12.3% vs 1.8%. CONCLUSION: Analysis revealed that didanosine-based 2nd-line regimens have limitations for South African children, given the high frequency of mutations that confer cross-resistance to didanosine; especially after abacavir-exposure. This data has influenced South African paediatric treatment guidelines, which now recommend zidovudine-based 2nd-line regimens.

  17. Characterization of the 1st and 2nd EF-hands of NADPH oxidase 5 by fluorescence, isothermal titration calorimetry, and circular dichroism

    Directory of Open Access Journals (Sweden)

    Wei Chin-Chuan

    2012-04-01

    Full Text Available Abstract Background Superoxide generated by non-phagocytic NADPH oxidases (NOXs is of growing importance for physiology and pathobiology. The calcium binding domain (CaBD of NOX5 contains four EF-hands, each binding one calcium ion. To better understand the metal binding properties of the 1st and 2nd EF-hands, we characterized the N-terminal half of CaBD (NCaBD and its calcium-binding knockout mutants. Results The isothermal titration calorimetry measurement for NCaBD reveals that the calcium binding of two EF-hands are loosely associated with each other and can be treated as independent binding events. However, the Ca2+ binding studies on NCaBD(E31Q and NCaBD(E63Q showed their binding constants to be 6.5 × 105 and 5.0 × 102 M-1 with ΔHs of -14 and -4 kJ/mol, respectively, suggesting that intrinsic calcium binding for the 1st non-canonical EF-hand is largely enhanced by the binding of Ca2+ to the 2nd canonical EF-hand. The fluorescence quenching and CD spectra support a conformational change upon Ca2+ binding, which changes Trp residues toward a more non-polar and exposed environment and also increases its α-helix secondary structure content. All measurements exclude Mg2+-binding in NCaBD. Conclusions We demonstrated that the 1st non-canonical EF-hand of NOX5 has very weak Ca2+ binding affinity compared with the 2nd canonical EF-hand. Both EF-hands interact with each other in a cooperative manner to enhance their Ca2+ binding affinity. Our characterization reveals that the two EF-hands in the N-terminal NOX5 are Ca2+ specific. Graphical abstract

  18. Analysis of the burden of treatment in patients receiving an EpiPen for yellow jacket anaphylaxis

    NARCIS (Netherlands)

    Oude Elberink, Joanne N. G.; van der Heide, S.; Guyatt, Gordon H.; Dubois, Anthony E. J.

    Background: Venom immunotherapy (VIT) is a treatment with established efficacy for the prevention of repeated anaphylactic reactions in patients with Hymenoptera allergy, which also allows patients to discontinue carrying an EpiPen. Despite their merits, both treatments can have negative aspects

  19. Visual pigment spectra of the comma butterfly, Polygonia c-album, derived from in vivo epi-illumination nation microspectrophotometry

    NARCIS (Netherlands)

    Vanhoutte, KJA; Stavenga, DG

    The visual pigments in the compound eye of the comma butterfly, Polygonia c-album, were investigate in a specially designed epi-illumination microspectrophotometer. Absorption changes due to photochemical conversions of the visual pigments, or due to light-independent visual pigment decay and

  20. Comparison of volume-selective z-shim and conventional EPI in fMRI studies using face stimuli

    CERN Document Server

    Fukunaga, Hu Cheng Srikanth Padmala Rena

    2013-01-01

    Single-shot gradient recalled echo planar imaging (EPI) is the primary tool for functional magnetic resonance imaging (fMRI). The image often suffers from signal drop near the air-tissue interface, such as the amygdala and regions of the orbitofrontal lobe. An effective way to correct for this type of artifact is by applying multi-shot EPI using different z-shimming. Unfortunately, the scanning efficiency is significantly lowered. More recently, a new technique called volume-selective z-shim was proposed to implement z-shim compensation to only specific slices with large susceptibility effects. The high imaging efficiency of volume selective z-shim makes it possible to substitute conventional EPI for whole brain studies. In this study two fMRI experiments were conducted to compare volume- selective z-shim and conventional EPI while subjects performed tasks on face stimuli. The comparison was focused on three brain regions: amygdala, hippocampus, and fusiform gyrus. Our results indicate that despite fewer volu...

  1. A stereoselective approach to indolizidine and pyrrolizidine alkaloids: total synthesis of (-)-lentiginosine, (-)-epi-lentiginosine and (-)-dihydroxypyrrolizidine.

    Science.gov (United States)

    Kauloorkar, Shruti Vandana; Jha, Vishwajeet; Jogdand, Ganesh; Kumar, Pradeep

    2014-07-07

    A simple and highly efficient approach to hydroxylated pyrrolizidine and indolizidine is developed from an aldehyde as a starting material using organocatalytic and asymmetric dihydroxylation reactions as key steps. Its application to the total synthesis of (-)-lentiginosine, (-)-epi-1,2-lentiginosine and (-)-dihydroxypyrrolizidine is also reported.

  2. Analysis of the burden of treatment in patients receiving an EpiPen for yellow jacket anaphylaxis

    NARCIS (Netherlands)

    Elberink, Joanne N. G. Oude; van der Heide, S.; Guyatt, Gordon H.; Dubois, Anthony E. J.

    2006-01-01

    Background: Venom immunotherapy (VIT) is a treatment with established efficacy for the prevention of repeated anaphylactic reactions in patients with Hymenoptera allergy, which also allows patients to discontinue carrying an EpiPen. Despite their merits, both treatments can have negative aspects pot

  3. Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate.

    NARCIS (Netherlands)

    Matsushita, K.; Mahmoodi, B.K.; Woodward, M.; Emberson, J.R.; Jafar, T.H.; Jee, S.H.; Polkinghorne, K.R.; Shankar, A.; Smith, D.H.; Tonelli, M.; Warnock, D.G.; Wen, C.P.; Coresh, J.; Gansevoort, R.T.; Hemmelgarn, B.R.; Levey, A.S.; Wetzels, J.F.

    2012-01-01

    CONTEXT: The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation more accurately estimates glomerular filtration rate (GFR) than the Modification of Diet in Renal Disease (MDRD) Study equation using the same variables, especially at higher GFR, but definitive evidence of its risk

  4. Visual pigment spectra of the comma butterfly, Polygonia c-album, derived from in vivo epi-illumination nation microspectrophotometry

    NARCIS (Netherlands)

    Vanhoutte, KJA; Stavenga, DG

    2005-01-01

    The visual pigments in the compound eye of the comma butterfly, Polygonia c-album, were investigate in a specially designed epi-illumination microspectrophotometer. Absorption changes due to photochemical conversions of the visual pigments, or due to light-independent visual pigment decay and regene

  5. 1st Quarter Transportation Report FY2017: Waste Shipments To and From the Nevada National Security Site (NNSS), Radioactive Waste Management Complex

    Energy Technology Data Exchange (ETDEWEB)

    Gregory, Louis [National Security Technologies, LLC. (NSTec), Las Vegas, NV (United States)

    2017-01-31

    This report satisfies the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office (NNSA/NFO) commitment to prepare a quarterly summary report of waste shipments to the Nevada National Security Site (NNSS) Radioactive Waste Management Complex (RWMC) at Area 5. This report summarizes the 1st quarter of fiscal year (FY) 2017 low-level radioactive waste (LLW), mixed low-level radioactive waste (MLLW) and classified non-radioactive (CNR) shipments. There were no shipments sent for offsite treatment from a NNSS facility and returned to the NNSS this quarter of FY2017.

  6. U.S. Army Chemical Corps Historical Studies, Gas Warfare in World War I: The 1st Division at Ansauville, January-April 1918

    Science.gov (United States)

    1958-01-01

    princip•al target of both enemy HE and gas fire at Ansauville was the 1st Division artillery, not the infantry. On both quiet and active fronts in the...of the gas fire was postponed on account of storm and rain. 434 JA. % *.. .. t .. t-. ,t. ,t.,,.4.:’... ,, ’. . w’. * ." .7 . , , , q I Io thought...against the enemy with gas fire . Butler’s journal indicates much more frequent use of gas, and this is confirmed by the artillery brigade summary which

  7. The Success of a Universal Hepatitis B Immunization Program as Part of Thailand's EPI after 22 Years' Implementation.

    Directory of Open Access Journals (Sweden)

    Nawarat Posuwan

    Full Text Available Hepatitis B vaccination for newborns was introduced in two provinces in 1988 as part of Thailand's Expanded Program on Immunization (EPI, and extended to the whole country in 1992. Our previous studies showed that children and adolescents who were born after the implementation of this program had a carrier rate of less than 1%, compared with 5-6% before implementation. In 2014 we performed hepatitis B serosurveys among 5964 subjects in the different geographic regions of the country to evaluate the long-term immunogenicity and impact of universal hepatitis B vaccination in newborns as part of the 22-year EPI program, by assessing HBsAg, anti-HBc and anti-HBs seropositivity status. The number of HB virus (HBV carriers, both children and young adults, who were born after universal HB vaccination was markedly reduced. The carrier rates among the age groups 6 months to 5 years, 5-10, 11-20, 21-30, 31-40, 41-50 and >50 years were respectively 0.1, 0.29, 0.69, 3.12, 3.78, 4.67 and 5.99%. The seropositivity rate for HBsAg in the post-EPI group was 0.6%, whereas in the pre-EPI group it was as high as 4.5% (p<0.001. HBV infection by means of detectable anti-HBc had also drastically declined in the population born after the HB vaccine was integrated into the EPI program. We estimated that the total number of HBV carriers amounted to 2.22 million, or 3.48% of the total population, most of whom are adults. The HB vaccine is the first vaccine shown to be effective in preventing the occurrence of chronic liver disease and hepatocellular carcinoma. Universal vaccination campaign will contribute to the eventual eradication of HBV-associated disease.

  8. Improving global data infrastructures for more effective and scalable analysis of Earth and environmental data: the Australian NCI NERDIP Approach

    Science.gov (United States)

    Evans, Ben; Wyborn, Lesley; Druken, Kelsey; Richards, Clare; Trenham, Claire; Wang, Jingbo; Rozas Larraondo, Pablo; Steer, Adam; Smillie, Jon

    2017-04-01

    The National Computational Infrastructure (NCI) facility hosts one of Australia's largest repositories (10+ PBytes) of research data collections spanning datasets from climate, coasts, oceans, and geophysics through to astronomy, bioinformatics, and the social sciences domains. The data are obtained from national and international sources, spanning a wide range of gridded and ungridded (i.e., line surveys, point clouds) data, and raster imagery, as well as diverse coordinate reference projections and resolutions. Rather than managing these data assets as a digital library, whereby users can discover and download files to personal servers (similar to borrowing 'books' from a 'library'), NCI has built an extensive and well-integrated research data platform, the National Environmental Research Data Interoperability Platform (NERDIP, http://nci.org.au/data-collections/nerdip/). The NERDIP architecture enables programmatic access to data via standards-compliant services for high performance data analysis, and provides a flexible cloud-based environment to facilitate the next generation of transdisciplinary scientific research across all data domains. To improve use of modern scalable data infrastructures that are focused on efficient data analysis, the data organisation needs to be carefully managed including performance evaluations of projections and coordinate systems, data encoding standards and formats. A complication is that we have often found multiple domain vocabularies and ontologies are associated with equivalent datasets. It is not practical for individual dataset managers to determine which standards are best to apply to their dataset as this could impact accessibility and interoperability. Instead, they need to work with data custodians across interrelated communities and, in partnership with the data repository, the international scientific community to determine the most useful approach. For the data repository, this approach is essential to enable

  9. 1st October 2010 - Chinese Vice President of the Academy of Sciences signing the guest book and exchanging gifts with CERN Director for Research and Scientific Computing S. Bertolucci, witnessed by Adviser R. Voss

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    1st October 2010 - Chinese Vice President of the Academy of Sciences signing the guest book and exchanging gifts with CERN Director for Research and Scientific Computing S. Bertolucci, witnessed by Adviser R. Voss

  10. Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa exchanging gifts at luncheon and signing the Guest Book on 1st November 2007 with CERN Director-General R. Aymar.

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa exchanging gifts at luncheon and signing the Guest Book on 1st November 2007 with CERN Director-General R. Aymar.

  11. Deciphering causal and statistical relations of molecular aberrations and gene expressions in NCI-60 cell lines

    Directory of Open Access Journals (Sweden)

    Li Shyh-Dar

    2011-11-01

    Full Text Available Abstract Background Cancer cells harbor a large number of molecular alterations such as mutations, amplifications and deletions on DNA sequences and epigenetic changes on DNA methylations. These aberrations may dysregulate gene expressions, which in turn drive the malignancy of tumors. Deciphering the causal and statistical relations of molecular aberrations and gene expressions is critical for understanding the molecular mechanisms of clinical phenotypes. Results In this work, we proposed a computational method to reconstruct association modules containing driver aberrations, passenger mRNA or microRNA expressions, and putative regulators that mediate the effects from drivers to passengers. By applying the module-finding algorithm to the integrated datasets of NCI-60 cancer cell lines, we found that gene expressions were driven by diverse molecular aberrations including chromosomal segments' copy number variations, gene mutations and DNA methylations, microRNA expressions, and the expressions of transcription factors. In-silico validation indicated that passenger genes were enriched with the regulator binding motifs, functional categories or pathways where the drivers were involved, and co-citations with the driver/regulator genes. Moreover, 6 of 11 predicted MYB targets were down-regulated in an MYB-siRNA treated leukemia cell line. In addition, microRNA expressions were driven by distinct mechanisms from mRNA expressions. Conclusions The results provide rich mechanistic information regarding molecular aberrations and gene expressions in cancer genomes. This kind of integrative analysis will become an important tool for the diagnosis and treatment of cancer in the era of personalized medicine.

  12. Prognostic Value of Prepro-Gastrin Releasing Peptide in Lung Cancer Patients; NCI-Prospective Study

    Science.gov (United States)

    Shafik, Nevine F; Rahoma, m; Elshimy, Reham A A; M Abou El kasem, Fatma

    2016-12-01

    Background: Prior series investigated the expression of prepro-gastrin releasing peptide (prepro-GRP) in the peripheral blood of lung cancer patients. Our aim was to assess any prepro-GRP role as a prognostic factor for small cell lung cancer (SCLC) and NSCLC and correlations with clinical presentation and treatment outcome. Methods: A prospective study was conducted during the time period from the beginning of January 2012 till the end of January 2014. Prepro-GRP expression was analysed using a nested RT-PCR assay in peripheral blood of 62 untreated lung cancer patients attending the National Cancer Institute (NCI), Cairo University, and 30 age and sex matched healthy volunteers. Results: Among the 62 lung cancer cases, there were 24 (38.7%) SCLC, and 38 (61.3%) NSCLC (10 squamous cell carcinomas, 12 adenocarcinomas, 11 large cell carcinomas, 4 undifferentiated carcinomas, and 1 adenosquamous carcinoma). Twenty six patients (41.9%) were prepro-GRP positive. Prepro-GRP expression was higher (58.3%) among SCLC patients compared to NSCLC (squamous cell carcinoma (15.4%), large cell carcinoma (36.4%), and adenocarcinoma (25%)). Mean OS among prepro-GRP negative cases was longer than that among preprogastrin positive cases (17.6 vs 14.9 months). The mean PFS durations among preprogastrin negative versus positive cases were 7.7 vs 4.6 months (p= 0.041). No difference in response to chemotherapy was identified between the groups (p=0.983). Conclusion: Prepro-GRP is suggested to be a useful prognostic marker for lung cancer patients, especially with the fast- growing, bad prognostic SCLC type. More studies should aim at detailed understanding of the mechanisms of prepro-GRP action and its use in monitoring the response to treatment in a larger cohort. Creative Commons Attribution License

  13. Final Report for the 1st Surveillance Test of the Reactor Pressure Vessel Material (CAPSULE 2) of Ulchin Nuclear Power Plant Unit 3

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Kee Ok; Kim, Byoung Chul; Lee, Sam Lai (and others)

    2006-12-15

    Surveillance testing for reactor vessel materials is performed in order to evaluate the irradiation embrittlement due to neutrons during operation and set the condition of safe operation of nuclear reactor. The 1st surveillance testing was performed completely by Korea Atomic Energy Research Institute at Taejon after the capsule was transported from Ulchin site including its removal from reactor. Fast neutron fluences for capsules were calculated and various testing including mechanical and chemistry analysis were performed in order to evaluate the integrity of Ulchin unit 3 reactor vessel during the operation until life time. The evaluation results are as follows; Fast neutron fluences for capsule 2 is 4.674E 18n/cm{sup 2}. The bias factor, the ratio of calculation/measurement, was 0.920 for the 1st testing and the calculational uncertainty,7.0% satisfied the requirement of USNRC Reg.Guide 1.190, 20%. The best estimated neutron fluence for reactor vessel inside surface was 3.913E 18n/cm{sup 2} based on the end of 6th fuel cycle and it was predicted that the fluences of vessel inside surface at 16 and 32EFPY would reach 9.249E 18 and 1.834E 19n/cm{sup 2} based on the current calculation. The result through this analysis for Ulchin unit 3 showed that there would be no problem for the pressurized thermal shock(PTS) during the operation until design life.

  14. Final Report for the 1st Surveillance Test of the Reactor Pressure Vessel Material (Capsule 2) of Ulchin Nuclear Power Plant Unit 4

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Kee Ok; Kim, Byoung Chul; Lee, Sam Lai (and others)

    2007-04-15

    Surveillance testing for reactor vessel materials is performed in order to evaluate the irradiation embrittlement due to neutrons during operation and set the condition of safe operation of nuclear reactor. The 1st surveillance testing was performed completely by Korea Atomic Energy Research Institute at Daejon after the capsule was transported from Ulchin site including its removal from reactor. Fast neutron fluences for capsules were calculated and various testing including mechanical and chemistry analysis were performed in order to evaluate the integrity of Ulchin Unit 4 reactor vessel during the operation until life time. The evaluation results are as follows; Fast neutron fluences for capsule 2 is 4.306E+18n/cm{sup 2}. The bias factor, the ratio of calculation/measurement, was 0.918 for the 1st testing and the calculational uncertainty,7.0% satisfied the requirement of USNRC Reg.Guide 1.190, 20%. The best estimated neutron fluence for reactor vessel inside surface was 3.615E+18n/cm{sup 2} based on the end of 6th fuel cycle and it was predicted that the fluences of vessel inside surface at 16 and 32EFPY would reach 8.478E+18 and 1.673E+19n/cm{sup 2} based on the current calculation. The result through this analysis for Ulchin Unit 4 showed that there would be no problem for the pressurized thermal shock(PTS) during the operation until design life.

  15. Despina Hatzifotiadou: ALICE Master Class 2 - Demonstration of the software for the 1st part of the exercise - visual identification of V0s

    CERN Document Server

    CERN. Geneva

    2016-01-01

    This is the 2nd of 4 short online videos. It contains a demonstration of the software used for the 1st part of the exercise, related to the theory explained in Master Class 1 - visual identification of V0s. More details and related links on this indico event page. In more detail: What is Physics Master Classes Students after morning lectures, run programmes in the afternoon to do measurements. These tutorials are about how to use the software required to do these measurements. Background info and examples  Looking for strange particles with ALICE http://aliceinfo.cern.ch/Public/MasterCL/MasterClassWebpage.html Introduction to first part of the exercise : what are strange particles, V0 decays, invariant mass. Demonstration of the software for the 1st part of the exercise - visual identification of V0s Introduction to second part of the exercise : strangeness enhancement; centrality of lead-lead collisions; explanation of efficiency, yield, background etc Demonstration of the software for the ...

  16. Toward personal eHealth in cardiology. Results from the EPI-MEDICS telemedicine project.

    Science.gov (United States)

    Rubel, Paul; Fayn, Jocelyne; Nollo, Giandomenico; Assanelli, Deodato; Li, Bo; Restier, Lioara; Adami, Stefano; Arod, Sébastien; Atoui, Hussein; Ohlsson, Mattias; Simon-Chautemps, Lucas; Télisson, David; Malossi, Cesare; Ziliani, Gian-Luca; Galassi, Alfredo; Edenbrandt, Lars; Chevalier, Philippe

    2005-10-01

    Despite many attempts to improve the management of acute myocardial infarction, only small trends to shorter time intervals before treatment have been reported. The self-care solution developed by the European EPI-MEDICS project (2001-2004) is a novel, very affordable, easy-to-use, portable, and intelligent Personal ECG Monitor (PEM) for the early detection of cardiac ischemia and arrhythmia that is able to record a professional-quality, 3-lead electrocardiogram (ECG) based on leads I, II, and V2; derive the missing leads of the standard 12-lead ECG (thanks to either a generic or a patient-specific transform), compare each ECG with a reference ECG by means of advanced neural network-based decision-making methods taking into account the serial ECG measurements and the patient risk factors and clinical data; and generate different levels of alarms and forward the alarm messages with the recorded ECGs and the patient's Personal electronic Health Record (PHR) to the relevant health care providers by means of a standard Bluetooth-enabled, GSM/GPRS-compatible mobile phone. The ECG records are SCP-ECG encoded and stored with the PHR on a secure personal SD Card embedded in the PEM device. The alarm messages and the PHR are XML encoded. Major alarm messages are automatically transmitted to the nearest emergency call center. Medium or minor alarms are sent on demand to a central PEM Alarm Web Server. Health professionals are informed by a Short Message Service. The PEM embeds itself a Web server to facilitate the reviewing and/or update of the PHR during a routine visit at the office of the general physician or cardiologist. Eighty PEM prototypes have been finalized and tested for several weeks on 697 citizens/patients in different clinical and self-care situations involving end users (188 patients), general physicians (10), and cardiologists (9). The clinical evaluation indicates that the EPI-MEDICS concept may save lives and is very valuable for prehospitalization triage.

  17. Die Transmurale ERP-Dispersion von Epi-,Mid-und Endomyokard im gesunden und hypertrophierten Hundemyokard

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Viele Studien haben das Vorliegen von M-Zellen im Midmyokard des Hundes in vitro beobachtet und weiterhin gefunden, da das Vorliegen von M-Zellen zur Differenz der Repolarisation und zur Dispersion der Refrakt?rzeit zwischen Midmyokard und Epi- und Endomyokard fuhren kann.Diese Dispersion hat enge Beziehungen mit der Entstehung der Arrhythmie. Aber die Beobachtungen in vitro waren nicht konkordant mit den Ergebnissen in vivo. Mittels direkten Messungen der ERP in drei Myokardschichten wurde erstmals im gesunden Hundemyokard und im hypertrophierten Hundemyokard in vivo untersucht. Die Untersuchung hat gezeigt, da die ERP von Endomyokard, Epimyokard und Midmyokard im gesunden Hundeherzen homogen sind. Die relevante transmurale Refrakt?rgradient, die die Induktion einer kreisenden Erregung begünstigt, besteht unter physiologischen Bedingungen nicht. Im Gegensatz dazu konnte eine deutliche Verl?ngerung der ERP in allen Myokardschichten von hypertrophierten Hundeherzen nachgewiesen werden. Weiterhin wurde gezeigt, d?eine transmurale ERP-Dispersion zwischen verschiedenen Myokardschichten im hypertrophierten Hundemyokard besteht. Es ist zu postulieren, d? diese transmurale ERP-Dispersion als Substrat für die Arrhythmie angesehen werden kann,weil diese Dispersion die lokalen kreisende Erregung zwischen Epikard und Midkard, oder zwischen Midkard und Endokard begünstigen kann. Nach den Ergebnissen l?t sich postulieren, d?eine transmurale ERP-Dispersion durch eine pl?tzliche Zyklusl?ngever?nderung, n?mlich durch eine Kurz-Lang- und eine Lang-Kurz-Sequenz verst?rkt werden kann.

  18. Further development of the EpiDerm 3D reconstructed human skin micronucleus (RSMN) assay.

    Science.gov (United States)

    Mun, Greg C; Aardema, Marilyn J; Hu, Ting; Barnett, Brenda; Kaluzhny, Yulia; Klausner, Mitchell; Karetsky, Viktor; Dahl, Erica L; Curren, Rodger D

    2009-03-17

    The upcoming ban on testing of cosmetics in animals by the European Union's 7th Amendment to the Cosmetics Directive will require genotoxicity safety assessments of cosmetics ingredients and final formulations to be based primarily on in vitro genotoxicity tests. The current in vitro test battery produces an unacceptably high rate of false positives, and used by itself would effectively prevent the use and development of many ingredients that are actually safe for human use. To address the need for an in vitro test that is more predictive of genotoxicity in vivo, we have developed an in vitro micronucleus assay using a three-dimensional human reconstructed skin model (EpiDerm) that more closely mimics the normal dermal exposure route of chemicals. We have refined this model and assessed its ability to predict genotoxicity of a battery of chemicals that have been previously classified as genotoxins or non-genotoxins based on in vivo rodent skin tests. Our reconstructed skin micronucleus assay correctly identified 7 genotoxins and 5 non-genotoxins, demonstrating its potential to have a higher predictive value than currently available in vitro genotoxicity tests, and its utility as part of a comprehensive in vitro genotoxicity testing strategy.

  19. Super-resolution imaging of multiple cells by optimized flat-field epi-illumination

    Science.gov (United States)

    Douglass, Kyle M.; Sieben, Christian; Archetti, Anna; Lambert, Ambroise; Manley, Suliana

    2016-11-01

    Biological processes are inherently multi-scale, and supramolecular complexes at the nanoscale determine changes at the cellular scale and beyond. Single-molecule localization microscopy (SMLM) techniques have been established as important tools for studying cellular features with resolutions of the order of around 10 nm. However, in their current form these modalities are limited by a highly constrained field of view (FOV) and field-dependent image resolution. Here, we develop a low-cost microlens array (MLA)-based epi-illumination system—flat illumination for field-independent imaging (FIFI)—that can efficiently and homogeneously perform simultaneous imaging of multiple cells with nanoscale resolution. The optical principle of FIFI, which is an extension of the Köhler integrator, is further elucidated and modelled with a new, free simulation package. We demonstrate FIFI's capabilities by imaging multiple COS-7 and bacteria cells in 100 × 100 μm2 SMLM images—more than quadrupling the size of a typical FOV and producing near-gigapixel-sized images of uniformly high quality.

  20. Os Episódios de Rita Patrício

    Directory of Open Access Journals (Sweden)

    Gustavo Rubim

    2014-12-01

    O texto propõe uma leitura do livro Episódios: da teorização estética em Fernando Pessoa, da au­toria de Rita Patrício. Datado de 2012, o livro só ficou realmente pronto e publicado em 2014. A leitura de­fende a originalidade deste exame minucioso dos textos de teoria estética e literária de Fernando Pessoa, tanto pela maneira como os trata autonomamente da obra poética e os estuda na sua escrita específica, quanto pelo efeito de deslocação dos tópicos habituais na análise do programa modernista português. A crí­tica do idealismo pessoano e da noção de obra enquanto totalidade or­gânica são sublinhados enquanto gestos condutores de toda a pesquisa. Propõem-se articulações com outros ensaios recentes que em Portugal procedem à revisão da crítica e da hermenêutica pes­soana.

  1. Design and Development of Nonlinear Optical Microscope System: Simple Implementation with epi-Illumination Platform

    Directory of Open Access Journals (Sweden)

    Ryu Jiheun

    2015-01-01

    Full Text Available During the research using fluorescence-tagged or auto-fluorescence molecules, meaningful information is often buried deep inside the tissue, not its surface. Therefore, especially in the field of biomedical imaging, acquiring optically sectioned images from deep inside the tissue is very important. As well know already, confocal laser scanning microscopy (the most well-known optical sectioning microscopy gives axially-resolved fluorescence information using the physical background blocking component called pinhole. However, the axial range of imaging is practically limited due to such optical phenomena as the light scattered and absorbed in the tissue. However, nonlinear optical microscopy (e.g. Multiphoton microscopy, harmonic generation microscopy, coherent anti-Stokes Raman spectroscopy realized by the development of ultrafast light sources has been used for visualizing various tissues, especially in vivo, because of their low sensitivity to the limitation caused by the scattering and the absorption of light. Although nonlinear optical microscopy gives deep tissue image, it is not easy for many researcher to build customized nonlinear system. Here, we introduce an easy and simple way designing and developing such nonlinear optical microscope with upright or inverted epi-illumination platform using commercial optical components only.

  2. Designing the Expanded Programme on Immunisation (EPI) as a service: Prioritising patients over administrative logic.

    Science.gov (United States)

    McKnight, Jacob; Holt, Douglas B

    2014-01-01

    Expanded Programme on Immunisation (EPI) vaccination rates remain well below herd immunity in regions of many countries despite huge international resources devoted to both financing and access. We draw upon service marketing theory, organisational sociology, development anthropology and cultural consumer research to conduct an ethnographic study of vaccination delivery in Jimma Zone, Ethiopia - one such region. We find that Western public health sector policies are dominated by an administrative logic. Critical failures in delivery are produced by a system that obfuscates the on-the-ground problems that mothers face in trying to vaccinate their children, while instead prioritising administrative processes. Our ethnographic analysis of 83 mothers who had not vaccinated their children reveals key barriers to vaccination from a 'customer' perspective. While mothers value vaccination, it is a 'low involvement' good compared to the acute daily needs of a subsistence life. The costs imposed by poor service - such as uncaring staff with class hostilities, unpredictable and missed schedules and long waits - are too much and so they forego the service. Our service design framework illuminates specific service problems from the mother's perspective and points towards simple service innovations that could improve vaccination rates in regions that have poor uptake.

  3. The in vivo trypanocidal effect of the diterpene 5-epi-icetexone obtained from Salvia gilliesii.

    Science.gov (United States)

    Lozano, E; Strauss, M; Spina, R; Cifuente, D; Tonn, C; Rivarola, H W; Sosa, M A

    2016-02-01

    The search for new compounds with trypanocidal activity is crucial for the treatment of Chagas' disease. Previous in vitro studies have shown that the diterpene 5-epi-icetexone (ICTX) is active against Trypanosoma cruzi. The aim of this work was to evaluate the effect of ICTX on the parasites in infected mice, in an experimental model that mimics the acute phase of the disease. Swiss albino mice were infected with T. cruzi and treated daily with 10mg/kg/day ICTX (i.p.). Infected mice and mice injected with either saline or the vehicle DMSO were used as controls. Animals' survival and parasitemia were monitored once a week and histological studies were made at necropsy by the 5th week after infection. It was observed that the administration of ICTX increased the survival of mice infected, and induced a significant decrease in the parasitemia, as compared to controls. A similar protective effect was observed when animals were treated orally with benznidazole (BZN, used as a control of antiparasitic effect). By the 5th week post-infection, the presence of amastigote nests was observed within the fibers of the cardiac and skeletal muscle in controls, but not in animals treated with either ICTX or BZN. In addition, inflammatory infiltrates were observed in the tissues of controls, but not in animals treated with the drugs. We conclude that ICTX has an antiparasitic effect against T. cruzi, thus constituting an interesting option for the treatment of Chagas' disease, alone or combined with other drugs.

  4. Anti-hepatitis B Virus Activity of 8-epi-Kingiside in Jasminum officinale var. grandiflorum

    Institute of Scientific and Technical Information of China (English)

    ZHAO; Gui-qin; YIN; Zhi-feng; LIU; Li-yan; MAO; Xiao-xia; SU; Zhan-hui

    2013-01-01

    Objective To evaluate the effect of 8-epi-kingiside (8-Epik) derived from the buds of Jasminum officinale var. grandiflorum (JOG) on hepatitis B virus (HBV) replication in HepG2 2.2.15 cell line in vitro and duck hepatitis B virus (DHBV) replication in ducklings in vivo. Methods The concentration of extracellular hepatitis B e antigen and hepatitis B surface antigen (HBsAg) in cell culture medium was determined by ELISA, respectively. The anti-HBV effects of 8-Epik were also demonstrated in the model of DHBV. 8-Epik was ip given (20, 40, and 80 mg/kg, twice daily) to the DHBV-infected ducklings for 10 d. The isotonic saline liquid diet was ip given as negative control and Lamivudine (50 mg/kg, twice daily) was given as positive control. DHBV DNA was measured at days 0 (T0), 5 (T5), 10 (T10), and day 3 after cessation of treatment (P3) by dot blotting. Results 8-Epik effectively blocked HBsAg secretion in HepG2 2.2.15 cells in a dose-dependent manner [IC 50 = (19.4 ± 1.04) μg/mL]. 8-Epik (40 or 80 mg/kg, ip, twice daily) also reduced viremia in DHBV-infected ducks. Conclusion Therefore, 8-Epik is warranted as a potential therapeutic agent for HBV infection.

  5. Continuous saturation EPI with diffusion weighting at 3.0 T.

    Science.gov (United States)

    Francis, S T; Gowland, P A; Bowtell, R W

    1999-11-01

    This paper presents a steady-state method of arterial spin labelling using continuous saturation in conjunction with echo-planar imaging (EPI), which has been implemented at 3 T. The continuous saturation technique has the advantage of having high sensitivity compared to transient labelling techniques, when long repetition times are used. It is also easy to implement and requires minimal data to be acquired for quantitation. Like other arterial spin labelling techniques, continuous saturation is potentially prone to overestimation of perfusion rates due to the effect of tagged blood in vessels within the image slice. Using a simple model of the vasculature, the degree of diffusion weighting required to suppress the arterial signal has been determined, with the results indicating that a value of 2 s/mm2 is adequate. Histogram analysis of the experimental data has been used to evaluate the effect of diffusion weighting. Using a b-value of 2 s/mm2, the mean perfusion-related signal change in grey matter on continuous saturation was found to be 1.5 +/- 0.2%, yielding a mean perfusion rate of 87 +/- 9 ml/100 g/min. Brain activation studies using the diffusion weighted continuous saturation technique gave a mean increase in perfusion of 36 +/- 12% in activated motor cortex.

  6. Computational Environments and Analysis methods available on the NCI High Performance Computing (HPC) and High Performance Data (HPD) Platform

    Science.gov (United States)

    Evans, B. J. K.; Foster, C.; Minchin, S. A.; Pugh, T.; Lewis, A.; Wyborn, L. A.; Evans, B. J.; Uhlherr, A.

    2014-12-01

    The National Computational Infrastructure (NCI) has established a powerful in-situ computational environment to enable both high performance computing and data-intensive science across a wide spectrum of national environmental data collections - in particular climate, observational data and geoscientific assets. This paper examines 1) the computational environments that supports the modelling and data processing pipelines, 2) the analysis environments and methods to support data analysis, and 3) the progress in addressing harmonisation of the underlying data collections for future transdisciplinary research that enable accurate climate projections. NCI makes available 10+ PB major data collections from both the government and research sectors based on six themes: 1) weather, climate, and earth system science model simulations, 2) marine and earth observations, 3) geosciences, 4) terrestrial ecosystems, 5) water and hydrology, and 6) astronomy, social and biosciences. Collectively they span the lithosphere, crust, biosphere, hydrosphere, troposphere, and stratosphere. The data is largely sourced from NCI's partners (which include the custodians of many of the national scientific records), major research communities, and collaborating overseas organisations. The data is accessible within an integrated HPC-HPD environment - a 1.2 PFlop supercomputer (Raijin), a HPC class 3000 core OpenStack cloud system and several highly connected large scale and high-bandwidth Lustre filesystems. This computational environment supports a catalogue of integrated reusable software and workflows from earth system and ecosystem modelling, weather research, satellite and other observed data processing and analysis. To enable transdisciplinary research on this scale, data needs to be harmonised so that researchers can readily apply techniques and software across the corpus of data available and not be constrained to work within artificial disciplinary boundaries. Future challenges will

  7. Specialty preferences of 1st year medical students in a Saudi Medical School – Factors affecting these choices and the influence of gender

    Science.gov (United States)

    Kaliyadan, Feroze; Amin, Tarek Tawfik; Qureshi, Habib; Al Wadani, Fahad

    2015-01-01

    Background and Aims: In recent years there has been a growing appreciation of the issues of career preference in medicine as it affects student learning and academic performance. Various factors influence the specialty choices of medical students. Some specialties tend to attract students more than others. One possible consequence of this would be a mismatch between health needs and specialist numbers in the region. This study investigated the career preferences of 1st year medical students in a Saudi medical school and to assess factors affecting these choices. Materials and Methods: The study was a cross-sectional survey carried out on the 1st year undergraduate students in the college of medicine, King Faisal University, Saudi Arabia. A total of 109 students (57 female and 52 males) responded to the questionnaire which was initially administered to all the students of the 1st year – A total of 120 students (response rate was 90.8%). A mixed method approach was used and qualitative data from open-ended questions were analyzed based on thematic analysis. Results: The top choices were general surgery, internal medicine, and pediatrics. Among female students; the top specialty choices were: General surgery (23%), pediatrics (18%), and dermatology (15%). Among the male students; the top choices were: General surgery (54%) and internal medicine (23%). Of the total, 57% of the students agreed or strongly agreed that primary aptitude was the main factor affecting the choice. Only 31% felt that there was a significant influence of role model, 48% felt that the advice of others – peers and family, would be a factor influencing their choices, and 53% agreed that specialty choice would influence their future learning patterns. Males were more likely to choose a specialty based on actual aptitude for the specialty, financial rewards, and scope for research; and this gender difference was statistically significant. Conclusion: Surgery was the top-choice in both genders

  8. Effect of milk feed source, frequency of feeding and age at turnout on calf performance, live-weight at mating and 1st lactation milk production.

    Science.gov (United States)

    Gleeson, David; O'Brien, Bernadette

    2012-10-18

    Female calves (n = 108) were assigned to 6 cold milk feeding treatments in two experiments for a 70-day period. Live-weight (LW) was measured weekly, with an additional LW taken at day 410 and post-calving for animals in experiment 1. In Experiment 1, the effect of feeding frequency and age of turnout to pasture on calf performance and 1st lactation milk yields were evaluated. The whole milk (WM) feeding treatments applied were (i) once daily feeding (OD), (ii) twice daily feeding (TD), (iii) OD feeding, outdoors at 38 days (ODO). In Experiment 2, the effects of feeding milk replacer (MR) as opposed to WM and age of turnout to pasture on calf performance were evaluated. The treatments applied were (i) OD feeding with WM (OD), (ii) OD feeding with milk replacer (MR) (ODMR), (iii) OD feeding with MR, outdoors at 38 days (ODMRO). Experiment 1: There were no differences (P > 0.05) in LW or average daily gain between TD and OD calves at day 80 or 410. ODO calves had lower LW at day 80 as compared to OD or TD (P Calf LW at day 80 was 86, 89 and 85 kg and at day 410 was 304, 309 and 316 kg for OD, TD and ODO, respectively. Milk feeding frequency or time of calf turnout had no effect on LW post calving, milk composition or 1st lactation milk yields. Experiment 2: Total LW at day 80 was higher (P Calf LW was 87, 95, and 88 kg for OD, ODMR and ODMRO, respectively. However, LW at day 410 did not differ between treatments.This study showed that while some differences were observed in calf LW at day 80, these differences had no effect on LW at day 410 or 1st lactation milk yield. It can be concluded that calves can be successfully reared when fed OD with WM or MR, indoors and when turned out to pasture at 38 days of age.

  9. Epi Info(R Now an Open-source application that continues a long and productive life through CDC support and funding

    Directory of Open Access Journals (Sweden)

    Enrique Nieves Jr

    2009-04-01

    Full Text Available The CDC’s National Center for Public Health Informatics (NCPHI recently released the Epi Info code to the public, making it the first Public Health Information Network (PHIN application to go open source. Because the code is freely available, other developers and other entities can work with the Epi Info™ code to add features, contribute enhancements, and make it a much better product. Going open source will also help Epi Info grow a wider user base, and as it grows, CDC hopes to attract more users who may want to help with development.

  10. FGFR2 is amplified in the NCI-H716 colorectal cancer cell line and is required for growth and survival.

    Science.gov (United States)

    Mathur, Anjili; Ware, Christopher; Davis, Lenora; Gazdar, Adi; Pan, Bo-Sheng; Lutterbach, Bart

    2014-01-01

    Aberrant kinase activation resulting from mutation, amplification, or translocation can drive growth and survival in a subset of human cancer. FGFR2 is amplified in breast and gastric cancer, and we report here the first characterization of FGFR2 gene amplification in colorectal cancer in the NCI-H716 colorectal cancer cell line. FGFR2 is highly expressed and activated in NCI-H716 cells, and FGFR selective small molecule inhibitors or FGFR2 shRNA strongly inhibited cell viability in vitro, indicating "addiction" of NCI-H716 cells to FGFR2. NCI-H716 growth in a xenograft model was also inhibited by an FGFR small molecule inhibitor. FGFR2 was required for activation of multiple downstream signaling proteins including AKT, ERK, S6RP and NFKB. Inhibition of downstream kinases such as AKT or ERK alone had modest effects on proliferation, whereas combined inhibition of AKT and ERK signaling resulted in a loss of viability similar to FGFR2 inhibition. We identified elevated FGFR2 expression in a small subset of primary colorectal cancer, however FGFR2 amplification was not observed. Although FGFR2 amplification is not common in primary colon cancer or lymph node and liver metastases, other subsets of colorectal cancer such as ascites, from which the NCI-H716 cell line was derived, have yet to be tested. These results suggest that emerging FGFR inhibitor therapeutics may have efficacy in a subset of colon cancer driven by FGFR2 amplification.

  11. FGFR2 is amplified in the NCI-H716 colorectal cancer cell line and is required for growth and survival.

    Directory of Open Access Journals (Sweden)

    Anjili Mathur

    Full Text Available Aberrant kinase activation resulting from mutation, amplification, or translocation can drive growth and survival in a subset of human cancer. FGFR2 is amplified in breast and gastric cancer, and we report here the first characterization of FGFR2 gene amplification in colorectal cancer in the NCI-H716 colorectal cancer cell line. FGFR2 is highly expressed and activated in NCI-H716 cells, and FGFR selective small molecule inhibitors or FGFR2 shRNA strongly inhibited cell viability in vitro, indicating "addiction" of NCI-H716 cells to FGFR2. NCI-H716 growth in a xenograft model was also inhibited by an FGFR small molecule inhibitor. FGFR2 was required for activation of multiple downstream signaling proteins including AKT, ERK, S6RP and NFKB. Inhibition of downstream kinases such as AKT or ERK alone had modest effects on proliferation, whereas combined inhibition of AKT and ERK signaling resulted in a loss of viability similar to FGFR2 inhibition. We identified elevated FGFR2 expression in a small subset of primary colorectal cancer, however FGFR2 amplification was not observed. Although FGFR2 amplification is not common in primary colon cancer or lymph node and liver metastases, other subsets of colorectal cancer such as ascites, from which the NCI-H716 cell line was derived, have yet to be tested. These results suggest that emerging FGFR inhibitor therapeutics may have efficacy in a subset of colon cancer driven by FGFR2 amplification.

  12. Carpel, a new Arabidopsis epi-mutant of the SUPERMAN gene: phenotypic analysis and DNA methylation status.

    Science.gov (United States)

    Rohde, A; Grunau, C; De Beck, L; Van Montagu, M; Rosenthal, A; Boerjan, W

    1999-09-01

    The carpel (car) mutation affects the morphology of reproductive organs in Arabidopsis thaliana. car flowers have an increased number of carpels, on average 2.7 +/- 0.8 instead of two in the wild type. Through allelism test with fon1-3 and analysis of the methylation state of the SUPERMAN (SUP) gene in car mutants, we show that car is an epi-mutation of SUP. The methylation pattern of car is clearly distinct from that of fon1-3, another epi-mutation of the SUP gene. Methylation was found predominantly in Cp(A/T)p(A/G) triplets and in CpG pairs. We suggest that the extensive SUP methylation in car has arisen from an abundant methylation of a single CpG site that was already present in abscisic acid-insensitive (abi3-4) mutants, from which car was segregating.

  13. EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor.

    Science.gov (United States)

    De Mol, Eva; Fenwick, R Bryn; Phang, Christopher T W; Buzón, Victor; Szulc, Elzbieta; de la Fuente, Alex; Escobedo, Albert; García, Jesús; Bertoncini, Carlos W; Estébanez-Perpiñá, Eva; McEwan, Iain J; Riera, Antoni; Salvatella, Xavier

    2016-09-16

    Castration-resistant prostate cancer is the lethal condition suffered by prostate cancer patients that become refractory to androgen deprivation therapy. EPI-001 is a recently identified compound active against this condition that modulates the activity of the androgen receptor, a nuclear receptor that is essential for disease progression. The mechanism by which this compound exerts its inhibitory activity is however not yet fully understood. Here we show, by using high resolution solution nuclear magnetic resonance spectroscopy, that EPI-001 selectively interacts with a partially folded region of the transactivation domain of the androgen receptor, known as transactivation unit 5, that is key for the ability of prostate cells to proliferate in the absence of androgens, a distinctive feature of castration-resistant prostate cancer. Our results can contribute to the development of more potent and less toxic novel androgen receptor antagonists for treating this disease.

  14. NCI-60 whole exome sequencing and pharmacological CellMiner analyses.

    Directory of Open Access Journals (Sweden)

    William C Reinhold

    Full Text Available Exome sequencing provides unprecedented insights into cancer biology and pharmacological response. Here we assess these two parameters for the NCI-60, which is among the richest genomic and pharmacological publicly available cancer cell line databases. Homozygous genetic variants that putatively affect protein function were identified in 1,199 genes (approximately 6% of all genes. Variants that are either enriched or depleted compared to non-cancerous genomes, and thus may be influential in cancer progression and differential drug response were identified for 2,546 genes. Potential gene knockouts are made available. Assessment of cell line response to 19,940 compounds, including 110 FDA-approved drugs, reveals ≈80-fold range in resistance versus sensitivity response across cell lines. 103,422 gene variants were significantly correlated with at least one compound (at p<0.0002. These include genes of known pharmacological importance such as IGF1R, BRAF, RAD52, MTOR, STAT2 and TSC2 as well as a large number of candidate genes such as NOM1, TLL2, and XDH. We introduce two new web-based CellMiner applications that enable exploration of variant-to-compound relationships for a broad range of researchers, especially those without bioinformatics support. The first tool, "Genetic variant versus drug visualization", provides a visualization of significant correlations between drug activity-gene variant combinations. Examples are given for the known vemurafenib-BRAF, and novel ifosfamide-RAD52 pairings. The second, "Genetic variant summation" allows an assessment of cumulative genetic variations for up to 150 combined genes together; and is designed to identify the variant burden for molecular pathways or functional grouping of genes. An example of its use is provided for the EGFR-ERBB2 pathway gene variant data and the identification of correlated EGFR, ERBB2, MTOR, BRAF, MEK and ERK inhibitors. The new tools are implemented as an updated web-based Cell

  15. [Comparison of the cardiovascular predictive value of MDRD and CKD-EPI in estimating chronic kidney disease].

    Science.gov (United States)

    Cinza-Sanjurjo, S; Calvo-Gómez, C; Hermida-Ameijeiras, A; López-Paz, J E; González-Juanatey, J R

    2016-01-01

    To assess predictive value of the cardiovascular prognosis by comparing the two most used formulas for the estimation of glomerular filtration rate in hypertensive patients. A retrospective cohort study was designed that included 405 patients diagnosed with essential hypertension. The patients were referred from Primary Care to the Hypertension and Vascular Risk Unit between January 1, 1998 and August 31, 1999. Blood pressure measurements, blood and urine analysis, and echocardiography were simultaneously performed. They were followed up for 12.5 years (mean [± IQR]: 10.61 [± 3.11] years) and 174 events were recorded. The study included 405 patients (53.8% women), with a mean age of 55.5 years. The estimated glomerular filtration rate according to the MDRD and CKD-EPI equations was 73.9±2.6 mL/min/1.73m(2) and 76.9±2.2 mL/min/1.73m(2), respectively. The prevalence of chronic kidney disease was 31.6% and 23.9%, respectively. Using the CKD-EPI equation led to the re-classification of 22.9% of patients. The incidence rate ratio (IRR [95%CI] for chronic kidney disease identified by the MDRD equation was 2.4 [1.8-3.3], and for the CKD-EPI calculation it was 2.5 [1.8 to 3.3]). Both equations estimate similar magnitudes of renal function, although the CKD-EPI equation has less false positives, and both have similar prognostic values in patients at high cardiovascular risk as well those at low risk. Copyright © 2014 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

  16. Tendències en el disseny metodològic de recerca sobre l’avaluació de competències a l’educació superior

    Directory of Open Access Journals (Sweden)

    Karina Angélica Villegas Sandoval

    2017-01-01

    Full Text Available L’article té com a finalitat descriure i analitzar les metodologies d'investigació utilitzades per estudis recents que aborden el tema de l’avaluació per competències a l’educació superior i la formació docent, per tal de detectar les tendències en el disseny metodològic i orientar futurs projectes d'investigació sobre aquest tema. El mètode de treball que s'ha seguit per dur a terme aquest estudi és l’anàlisi de contingut de 22 documents trobats a Dialnet. Els resultats mostren que les investigacions que tracten el tema assenyalat han anat en augment en els últims tretze anys, i es destaca el canvi de metodologia utilitzada, amb dissenys majoritàriament descriptius i avaluatius. Al seu torn, però, crida l'atenció que un gran nombre d'estudis no expliquen ni el mètode ni el disseny d'investigació que han aplicat. Es conclou que és important que les investigacions presentin un apartat que al·ludeixi al disseny metodològic a fi d’afavorir la comprensió del lector dels processos d'indagació que s'han dut a terme.

  17. 1(st) EMBL/DFG Women in Science Network Conference Heidelberg 2016: From Genes, Cells and the Immune System towards Therapies - Meeting Report.

    Science.gov (United States)

    Stripecke, Renata; Gouttefangeas, Cécile; Förster, Irmgard

    2016-11-01

    The 1(st) EMBL/DFG Women in Science (WiS) Conference "From Genes, Cells and the Immune System towards Therapies" was held on 19(th) - 20(th) September 2016 in Heidelberg, Germany. The WiS conference was funded by nine Collaborative Research Centers (CRCs) of the German Research Council (Deutsche Forschungsgemeinschaft, DFG; Table 1) and benefited from an outstanding hosting environment at the Advanced Training Center of the European Molecular Biology Laboratory (EMBL). Scientific talks focused at genetic, cellular and immunologic mechanisms, and immune therapy, and progress from all stages of development covering basic research to clinical developments was described. The presentations were embedded between structured networking sessions and a round table discussion with representatives of the DFG, EMBL, European Molecular Biology Organisation (EMBO), and the German Society of Immunology (DGfI). © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Understanding Stress-Related Behavioral Phenotypes: Report from the 1st International Neuroscience Summer School and the 11th International “Stress and Behavior” Conference

    Directory of Open Access Journals (Sweden)

    J. L. LaPorte

    2008-01-01

    Full Text Available The 1st International Neuroscience Summer School and the 11th International Multidisciplinary Neuroscience and Biopsychiatry Conference on Stress and Behavior were held in St. Petersburg, Russia, during May 9–20, 2008. The summer school gathered 30 talented young scientists from 15 countries worldwide, and was dedicated to different topics of behavioral neuroscience. Many interactive courses were provided on neuropharmacology, animal phenotyping, and biopsychology. The conference's excellent scientific and social program attracted almost 500 delegates from 40 countries from many areas of stress research. The eclectic interaction between medical doctors, basic scientists, psychologists, and students made for a productive and collaborative environment, which contributed greatly to the success of the school and conference.

  19. Comparative analysis of effectiveness of treatment with anti-TB drugs of the 1st and 2nd lines for children and adolescents with multidrug resistant tuberculosis

    Directory of Open Access Journals (Sweden)

    Tleukhan Abildaev

    2012-05-01

    Full Text Available The paper shows results of study on comparative treatment effectiveness in children and adolescents with from multi drug resistant tuberculosis MDR TB (2000-2008 treated with anti-TB drugs of the 2nd line (80 patients and 1st line (80 patients in the Kazakhstan. It was stated in patients with MDR TB that outcomes of treatment were successful in 91.2%, but relapse development of TB disease occurred in 12.7% of cases, and 5 (6.2% patients died (P ≤0.05. Thus, patients with MDR TB need to be treated with anti-TB drugs of the 2nd line accordingly to their DST.

  20. 1st European Congress of Medical Physics September 1-4, 2016; Medical Physics innovation and vision within Europe and beyond.

    Science.gov (United States)

    Tsapaki, Virginia; Kagadis, George C; Brambilla, Marco; Ciocca, Mario; Clark, Catharine H; Delis, Harry; Mettivier, Giovanni

    2017-09-01

    Medical Physics is the scientific healthcare profession concerned with the application of the concepts and methods of physics in medicine. The European Federation of Organisations for Medical Physics (EFOMP) acts as the umbrella organization for European Medical Physics societies. Due to the rapid advancements in related scientific fields, medical physicists must have continuous education through workshops, training courses, conferences, and congresses during their professional life. The latest developments related to this increasingly significant medical speciality were presented during the 1st European Congress of Medical Physics 2016, held in Athens, September 1-4, 2016, organized by EFOMP, hosted by the Hellenic Association of Medical Physicists (HAMP), and summarized in the current volume. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.